Refseq_ID	Mycobrowser_Version	Feature	Start	Stop	Score	Strand	Frame	Locus	Name	Function	Product	Comments	UniProt_AC	Is_Pseudogene	Functional_Category	Protein Data Bank	PFAM	UniProt	Gene Ontology	Enzyme Classification	Drug Resistance Mutations	InterPro	UniProtKB/TrEMBL	SWISS-MODEL	Orthologues M. leprae	Orthologues M. marinum	Orthologues M. smegmatis	Orthologues M. tuberculosis	Orthologues M. lepromatosis	Orthologues M. tuberculosis	Orthologues M. abscessus	Orthologues M. haemophilum	Orthologues M. orygis
NC_002945.3	Mycobrowser_v4	CDS	705075	705302	.	+	0	Mb0626	Mb0626		CONSERVED HYPOTHETICAL PROTEIN	Mb0626, -, len: 75 aa. Equivalent to Rv0609A, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Conserved hypothetical protein, highly similar to part of upstream ORF Rv0612|MTCY19H5.09c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (201 aa), FASTA scores: opt: 154, E(): 1.8e-05, (74.3% identity in 35 aa overlap).	Q7U1M7,A0A1R3XY04	No	conserved hypotheticals			A0A1R3XY04					Q7U1M7					Rv0609A		Rv0609A			
NC_002945.3	Mycobrowser_v4	CDS	699769	700239	.	-	0	Mb0617c	Mb0617c		two component sensor kinase [first part]	Mb0617c, -, len: 156 aa. Equivalent to Rv0601c,len: 156 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 156 aa overlap). Probable two-component sensor kinase (first part) (EC 2.7.3.-), similar to part (N-termini) of others e.g. Q0375|CUTS_STRLI cuts protein from streptomyces lividans (414 aa), FASTA scores: opt: 230, E(): 3.1e-08,(39.1% identity in 115 aa overlap). Note that the sequence was checked and no errors were detected that would allow this and the downstream ORF to be joined.	Q7U1N5,A0A1R3XWV4	No	regulatory proteins			A0A1R3XWV4				IPR003660,IPR003661,IPR009082	Q7U1N5					Rv0601c		Rv0601c			
NC_002945.3	Mycobrowser_v4	CDS	1516798	1517169	.	+	0	Mb1387	Mb1387		conserved protein	Mb1387, -, len: 123 aa. Equivalent to Rv1352, len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 123 aa overlap). Conserved hypothetical protein, some similarity to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa overlap).	X2BHN0,P64824	No	conserved hypotheticals			P64824					X2BHN0					Rv1352		Rv1352			
NC_002945.3	Mycobrowser_v4	CDS	1537215	1537475	.	+	0	Mb1401A	Mb1401A		Conserved protein	Mb1401A, len: 86 aa. Equivalent to Rv1366A len: 86 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 86 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BHP3,A0A1R3XY61	No	conserved hypotheticals			A0A1R3XY61					X2BHP3					Rv1366A		Rv1366A			
NC_002945.3	Mycobrowser_v4	CDS	1764680	1765090	.	+	0	Mb1599	Mb1599		Probable phiRV1 phage protein	Mb1599, -, len: 136 aa. Equivalent to Rv1573, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Probable phiRv1 phage protein (see citation below).	Q7VEY3,A0A1R3Y0V5	No	insertion seqs and phages			A0A1R3Y0V5					Q7VEY3					Rv1573		Rv1573			
NC_002945.3	Mycobrowser_v4	CDS	1769272	1769667	.	-	0	Mb1607c	Mb1607c		Probable phiRv1 phage protein	Mb1607c, -, len: 131 aa. Equivalent to Rv1581c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 131 aa overlap). Probable phiRv1 phage protein (see citation below).	Q7VEX5,A0A1R3XYP8	No	insertion seqs and phages			A0A1R3XYP8				IPR001623	Q7VEX5					Rv1581c		Rv1581c			
NC_002945.3	Mycobrowser_v4	CDS	1776700	1776939	.	+	0	Mb1616	Mb1616		CONSERVED HYPOTHETICAL PROTEIN	Mb1616, -, len: 79 aa. Equivalent to Rv1590, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 79 aa overlap). Conserved hypothetical protein, similar to Q49616|LEPB1170_C1_162|YF90_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 368, E(): 1.7e-21, Smith-Waterman score: 368, (67.1% identity in 73 aa overlap).	X2BIS6,P64882	No	conserved hypotheticals			P64882					X2BIS6					Rv1590		Rv1590			
NC_002945.3	Mycobrowser_v4	CDS	787918	788715	.	+	0	Mb0705	Mb0705		PROBABLE MEMBRANE PROTEIN	Mb0705, -, len: 265 aa. Equivalent to Rv0686, len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 265 aa overlap). Probable membrane protein, with hydrophobic N-terminus.	Q7U1G9,A0A1R3XX44	No	cell wall and cell processes			A0A1R3XX44					Q7U1G9					Rv0686		Rv0686			
NC_002945.3	Mycobrowser_v4	CDS	2508042	2508236	.	-	0	Mb2279c	Mb2279c		HYPOTHETICAL PROTEIN	Mb2279c, -, len: 64 aa. Equivalent to Rv2255c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Hypothetical unknown protein.	Q7TYW3,A0A1R3Y0Q3	No	conserved hypotheticals			A0A1R3Y0Q3					Q7TYW3					Rv2255c		Rv2255c			
NC_002945.3	Mycobrowser_v4	CDS	1052827	1053105	.	+	0	Mb0967	Mb0967		HYPOTHETICAL PROTEIN	Mb0967, -, len: 92 aa. Equivalent to Rv0942, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 92 aa overlap). Hypothetical unknown protein.	X2BGM0,P64764	No	conserved hypotheticals			P64764					X2BGM0					Rv0942		Rv0942			
NC_002945.3	Mycobrowser_v4	CDS	1076635	1077117	.	-	0	Mb0989c	Mb0989c		HYPOTHETICAL PROTEIN	Mb0989c, -, len: 160 aa. Equivalent to Rv0964c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 160 aa overlap). Hypothetical unknown protein. Equivalent to AAK45241.1 from Mycobacterium tuberculosis strain CDC1551 (138 aa) but longer 22 aa.	X2BGQ4,P59978	No	conserved hypotheticals			P59978					X2BGQ4					Rv0964c		Rv0964c			
NC_002945.3	Mycobrowser_v4	CDS	1536425	1537246	.	+	0	Mb1401	Mb1401		HYPOTHETICAL PROTEIN	Mb1401, -, len: 273 aa. Equivalent to Rv1366, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Hypothetical unknown protein.	X2BHW3,P64834,P64834	No	conserved hypotheticals			P64834					X2BHW3,P64834					Rv1366		Rv1366			
NC_002945.3	Mycobrowser_v4	CDS	1589812	1590285	.	+	0	Mb1454	Mb1454		unknown protein	Mb1454, -, len: 157 aa. Equivalent to Rv1419, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 157 aa overlap). Hypothetical unknown protein.	X2BHK4,P64850,P64850	No	conserved hypotheticals			P64850					X2BHK4,P64850					Rv1419		Rv1419			
NC_002945.3	Mycobrowser_v4	CDS	2194652	2195266	.	-	0	Mb1993c	Mb1993c		HYPOTHETICAL PROTEIN	Mb1993c, -, len: 204 aa. Equivalent to Rv1958c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Hypothetical unknown protein.	Q7TZ74,A0A1R3Y088	No	conserved hypotheticals			A0A1R3Y088					Q7TZ74					Rv1958c		Rv1958c			
NC_002945.3	Mycobrowser_v4	CDS	1676068	1677375	.	+	0	Mb1527	Mb1527		PROBABLE MEMBRANE PROTEIN	Mb1527, -, len: 435 aa. Equivalent to Rv1490, len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 435 aa overlap). Probable membrane protein.	X2BIJ5,P64858,P64858	No	cell wall and cell processes			P64858					X2BIJ5,P64858					Rv1490		Rv1490			
NC_002945.3	Mycobrowser_v4	CDS	1730932	1731159	.	+	0	Mb1572	Mb1572		HYPOTHETICAL PROTEIN	Mb1572, -, len: 75 aa. Equivalent to Rv1545, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Hypothetical unknown protein.	X2BIN7,P64872	No	conserved hypotheticals			P64872					X2BIN7					Rv1545		Rv1545			
NC_002945.3	Mycobrowser_v4	CDS	1760226	1760510	.	-	0	Mb1594c	Mb1594c		probable hypothetical membrane protein	Mb1594c, -, len: 94 aa. Equivalent to Rv1567c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Probable membrane protein.	Q7VEY4,A0A1R3XYQ4	No	cell wall and cell processes			A0A1R3XYQ4					Q7VEY4					Rv1567c		Rv1567c			
NC_002945.3	Mycobrowser_v4	CDS	1768675	1768989	.	-	0	Mb1605c	Mb1605c		Probable phiRv1 phage protein	Mb1605c, -, len: 104 aa. Equivalent to Rv1579c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 104 aa overlap). Probable phiRv1 phage protein (see citation below).	Q7VEX7,A0A1R3XYR0	No	insertion seqs and phages			A0A1R3XYR0					Q7VEX7					Rv1579c		Rv1579c			
NC_002945.3	Mycobrowser_v4	CDS	1881121	1881483	.	+	0	Mb1696	Mb1696		HYPOTHETICAL PROTEIN	Mb1696, -, len: 120 aa. Equivalent to Rv1669, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 120 aa overlap). Hypothetical unknown protein.	Q7TZU1,A0A1R3XZ00	No	conserved hypotheticals			A0A1R3XZ00					Q7TZU1					Rv1669		Rv1669			
NC_002945.3	Mycobrowser_v4	CDS	1935972	1936391	.	-	0	Mb1753c	Mb1753c		HYPOTHETICAL PROTEIN	Mb1753c, -, len: 139 aa. Equivalent to Rv1724c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 139 aa overlap). Hypothetical unknown protein.	Q7TZQ0,A0A1R3XZH9	No	conserved hypotheticals			A0A1R3XZH9					Q7TZQ0					Rv1724c		Rv1724c			
NC_002945.3	Mycobrowser_v4	CDS	2192857	2193378	.	-	0	Mb1989c	Mb1989c		HYPOTHETICAL PROTEIN	Mb1989c, -, len: 173 aa. Equivalent to Rv1954c,len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 173 aa overlap). Hypothetical unknown protein, end overlaps next ORF upstream, Rv1955 (MTCY09F9.09c).	Q7TZ78,A0A1R3XZV7	No	conserved hypotheticals			A0A1R3XZV7					Q7TZ78					Rv1954c		Rv1954c			
NC_002945.3	Mycobrowser_v4	CDS	2314923	2315174	.	-	0	Mb2101c	Mb2101c		conserved hypothetical protein	Mb2101c, -, len: 83 aa. Equivalent to Rv2076c, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Unknown, questionable ORF	X2BJN0,P64932,P64932	No	conserved hypotheticals			P64932					X2BJN0,P64932					Rv2076c		Rv2076c			
NC_002945.3	Mycobrowser_v4	CDS	2693723	2694028	.	-	0	Mb2452c	Mb2452c			Mb2452c, -, len: 101 aa. Equivalent to the second part of oxyR' pseudogene (see citation below).		No																			
NC_002945.3	Mycobrowser_v4	CDS	82783	84018	.	+	0	Mb0076	Mb0076		conserved protein	Mb0076, -, len: 411 aa. Equivalent to Rv0074, len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Conserved hypothetical protein, similar to Rv2915c|MTCY338.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and showing some simlarity to various enzymes or hypothetical proteins from other organisms, eg NP_243801.1|NC_002570 aryldialkylphosphatase from Bacillus halodurans (394 aa); NP_421471.1|NC_002696 putativ Xaa-Pro dipeptidase from Caulobacter crescentus (429 aa); NP_343436.1|NC_002754 Prolidase (Xaa-Pro dipeptidase) (pepQ-like2) from Sulfolobus solfataricus (408 aa); Q50432|M91040 ORGANO PHOSPHATE ACID ANHYDRASE OPAB from MYCOBACTERIUM SP. (409 aa), FASTA scores: opt: 166, E(): 3.9e-11, (31.2% identity in 430 aa overlap); etc.	Q7U2W9,A0A1R3XU90	No	conserved hypotheticals			A0A1R3XU90				IPR006680,IPR011059	Q7U2W9					Rv0074		Rv0074			
NC_002945.3	Mycobrowser_v4	CDS	4434	4997	.	+	0	Mb0004	Mb0004		CONSERVED HYPOTHETICAL PROTEIN	Mb0004, -, len: 187 aa. Equivalent to Rv0004, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Conserved hypothetical protein (see citation below), highly similar, but longer 21 aa in N-terminus, to AAF33696.1|AF222789 unknown protein from Mycobacterium avium subsp. paratuberculosis (166 aa); and highly similar to NP_301132.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (189 aa); S70990 hypothetical protein from Mycobacterium smegmatis (194 aa). Also similar to in C-terminus to C-terminal part of P35925|YREG_STRCO HYPOTHETICAL 19.8 KDA PROTEIN (IN RECF-GYRB INTERGENIC REGION) from Streptomyces coelicolor (190 aa), FASTA scores: opt: 404, E(): 3.9e-18,(40.7% identity in 189 aa overlap).	X2BDR3,Q7U313	No	conserved hypotheticals			Q7U313					X2BDR3					Rv0004		Rv0004			
NC_002945.3	Mycobrowser_v4	CDS	85671	86501	.	-	0	Mb0079c	Mb0079c		PROBABLE OXIDOREDUCTASE	Mb0079c, -, len: 276 aa. Equivalent to Rv0077c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Possible oxidoreductase (EC 1.-.-.-), weakly similar to others e.g. CAC44600.1|AL596162 putative oxidoreductase from Streptomyces coelicolor (275 aa); P33912|BPA1_STRAU NON-HAEM BROMOPEROXIDASE BPO-A1 (BROMIDE PEROXIDASE) (EC 1.11.1.-) from Streptomyces aureofaciens (275 aa); BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 230, E(): 1.5e-07, (26.1% identity in 249 aa overlap); etc. Also similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium tuberculosis. And shows some similarity in part with AAL17935.1|AY054120 putative epoxide hydrolase from Mycobacterium smegmatis (203 aa).	Q7U2W6,A0A1R3XUF2	No	intermediary metabolism and respiration			A0A1R3XUF2				IPR000073	Q7U2W6					Rv0077c		Rv0077c			
NC_002945.3	Mycobrowser_v4	CDS	27576	28346	.	+	0	Mb0023	Mb0023		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0023, -, len: 256 aa. Equivalent to Rv0023, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible transcriptional regulator, equivalent to CAB96432.1|AJ251434 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (146 aa). N-terminus showing similarity with other transcriptional regulators e.g. AE0002|ECAE000240_9 from Escherichia coli strain K12 (178 aa), FASTA scores: opt: 149, E(): 0.0048,(33.3% identity in 84 aa overlap); etc. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD).	X2BDT3,P67705,P67705	No	regulatory proteins			P67705					X2BDT3,P67705					Rv0023		Rv0023			
NC_002945.3	Mycobrowser_v4	CDS	3282790	3283638	.	+	0	Mb2996	Mb2996		PROBABLE OXIDOREDUCTASE	Mb2996, -, len: 282 aa. Equivalent to Rv2971, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly aldo/keto reductase,equivalent to O69462 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495,E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C OXIDOREDUCTASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 849, E(): 1.2e-49, (51.7% identity in 267 aa overlap); Q9ZBW7|SC4B5.01C PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49,(49.1% identity in 271 aa overlap); Q46857|YQHE_ECOLI|YQHE|B3012 HYPOTHETICAL OXIDOREDUCTASE from Escherichia coli strain K12 (275 aa), FASTA scores: opt: 827, E(): 3.7e-48, (47.45% identity in 276 aa overlap); etc. Contains PS00063 Aldo	X2BMD1,Q7TXI6	No	intermediary metabolism and respiration								X2BMD1,Q7TXI6	Q7TXI6				Rv2971		Rv2971			
NC_002945.3	Mycobrowser_v4	CDS	3392345	3392869	.	-	0	Mb3099c	Mb3099c		CONSERVED HYPOTHETICAL PROTEIN	Mb3099c, -, len: 174 aa. Equivalent to Rv3072c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Hypothetical protein,similar in part to O87779 HYPOTHETICAL 18.1 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (166 aa),FASTA scores: opt: 238, E(): 2.5e-08, (42.6% identity in 108 aa overlap); Q9AH10 PUTATIVE F420-DEPENDENT DEHYDROGENASE from Rhodococcus erythropolis (295 aa),FASTA scores: opt: 228, E(): 1.7e-07, (34.25% identity in 111 aa overlap); P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 POSSIBLE OXIDOREDUCTASE from Mycobacterium tuberculosis strain H37Rv (304 aa), FASTA scores: opt: 208, E(): 3.2e-06, (38.9% identity in 108 aa overlap); etc. N-terminal region similar to several proteins from M. tuberculosis (see MAST results on the web site http:	Q7TXB6	No	conserved hypotheticals							IPR011251	Q7TXB6	A0A1R3Y328				Rv3072c		Rv3072c			
NC_002945.3	Mycobrowser_v4	CDS	165513	166016	.	+	0	Mb0143	Mb0143		CONSERVED HYPOTHETICAL PROTEIN	Mb0143, -, len: 167 aa. Equivalent to Rv0138, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 167 aa overlap). Conserved hypothetical protein, showing weak similarity to Q10827|YT10_MYCTU HYPOTHETICAL 17.0 KDA PROTEIN from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 131, E(): 0.047,(31.15% identity in 106 aa overlap).	Q7U2S0,A0A1R3XUE9	No	conserved hypotheticals			A0A1R3XUE9				IPR009959	Q7U2S0					Rv0138		Rv0138			
NC_002945.3	Mycobrowser_v4	CDS	9914	10828	.	+	0	Mb0007	Mb0007		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb0007, -, len: 304 aa. Equivalent to Rv0007, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Possible conserved membrane protein, highly similar to Z70722|MLCB1770_7 from Mycobacterium leprae (303 aa), FASTA scores: opt: 812,E(): 1.6e-25, (54.2% identity in 319 aa overlap). C-terminal part highly similar to C-terminus of CAB92992.1|AL357152 putative integral membrane protein from Streptomyces coelicolor (185 aa); and N-terminal part highly similar to C-terminus of NP_302684.1|NC_002677 hypothetical protein from Mycobacterium leprae (123 aa).	Q7U310,A0A1R3XW78	No	cell wall and cell processes			A0A1R3XW78				IPR021949	Q7U310					Rv0007		Rv0007			
NC_002945.3	Mycobrowser_v4	CDS	102850	103698	.	-	0	Mb0096c	Mb0096c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0096c, -, len: 282 aa. Equivalent to Rv0093c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Probable conserved membrane protein, equivalent only to CAC30943.1|AL583924 probable integral membrane protein from Mycobacterium leprae (237 aa).	Q7U2V4,A0A1R3XWG9	No	cell wall and cell processes			A0A1R3XWG9				IPR027383	Q7U2V4					Rv0093c		Rv0093c			
NC_002945.3	Mycobrowser_v4	CDS	13222	13557	.	-	0	Mb0010c	Mb0010c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0010c, -, len: 111 aa. Equivalent to Rv0010c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Probable conserved membrane protein, equivalent to NP_301139.1|NC_002677 putative membrane protein from Mycobacterium leprae (137 aa); and similar to Rv1417|P71686|YE17_MYCTU HYPOTHETICAL 16.4 KD PROTEIN from Mycobacterium tuberculosis (154 aa),FASTA scores: opt: 121, E(): 0.097, (29.6% identity in 81 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa).	Q7U309,A0A1R3XUN1	No	cell wall and cell processes			A0A1R3XUN1				IPR019692	Q7U309					Rv0010c		Rv0010c			
NC_002945.3	Mycobrowser_v4	CDS	13713	13994	.	-	0	Mb0011c	Mb0011c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0011c, -, len: 93 aa. Equivalent to Rv0011c, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable conserved transmembrane protein, equivalent to NP_301140.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (93 aa); and similar to AL079308|SCH69_24 hypothetical protein from Streptomyces coelicolor (84 aa), FASTA scores: opt: 135, E(): 0.0068, (32.6% identity in 92 aa overlap).	X2BDR8,P67377,P67377	No	cell wall and cell processes			P67377					X2BDR8,P67377					Rv0011c		Rv0011c			
NC_002945.3	Mycobrowser_v4	CDS	14088	14876	.	+	0	Mb0012	Mb0012		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0012, -, len: 262 aa. Equivalent to Rv0012, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv (99.2% identity in 262 aa overlap). Probable conserved membrane protein, similar to AL079308|SCH69_23|T36722 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 506, E(): 1.9e-25, (39.8% identity in 236 aa overlap). Some similarity to BLU0|1958_35A2 DIVIB (fragment) (188 aa), FASTA scores: opt: 204, E(): 8.9e-07, (35.6% identity in 90 aa overlap); and G1129091|DDS cell division and sporulation protein from Bacillus subtilis (231 aa), FASTA scores: opt: 180, E(): 3.8e-05, (30.7% identity in 101 aa overlap). Also similar to Rv1823|MTCY1A11_20 from Mycobacterium tuberculosis FASTA score: (30.1% identity in 246 aa overlap); and MTCY1A11_18 FASTA score: (25.5% identity in 235 aa overlap). Contains probable N-terminal signal sequence.	Q7U308,A0A1R3XU20	No	cell wall and cell processes			A0A1R3XU20				IPR010273	Q7U308					Rv0012		Rv0012			
NC_002945.3	Mycobrowser_v4	CDS	36851	37246	.	+	0	Mb0035	Mb0035		CONSERVED HYPOTHETICAL PROTEIN	Mb0035, -, len: 131 aa. Equivalent to Rv0034, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing weak similarity to AE001980|AE001980_7 hypothetical protein from Deinococcus radiodurans (120 aa), FASTA scores: opt: 141, E(): 0.0028,(29.3% identity in 123 aa overlap).	X2BDT9,P64674	No	conserved hypotheticals			P64674					X2BDT9					Rv0034		Rv0034			
NC_002945.3	Mycobrowser_v4	CDS	383520	383906	.	+	0	Mb0321	Mb0321		conserved protein	Mb0321, -, len: 128 aa. Equivalent to Rv0313, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, equivalent only to CAC32049.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (130 aa). TBparse score is 0.877.	Q7U2A4,A0A1R3XVI1	No	conserved hypotheticals			A0A1R3XVI1					Q7U2A4					Rv0313		Rv0313			
NC_002945.3	Mycobrowser_v4	CDS	96962	97636	.	+	0	Mb0091	Mb0091		possible polyketide cyclase/dehydrase	Mb0091, -, len: 224 aa. Equivalent to Rv0088, len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Hypothetical unknown protein.	X2BDZ8,P0A5C4	No	lipid metabolism			P0A5C4					X2BDZ8					Rv0088		Rv0088			
NC_002945.3	Mycobrowser_v4	CDS	59886	60407	.	+	0	Mb0058	Mb0058		HYPOTHETICAL PROTEIN	Mb0058, -, len: 173 aa. Equivalent to Rv0057, len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 173 aa overlap). Hypothetical unknown protein.	X2BDW3,P64680	No	conserved hypotheticals			P64680					X2BDW3					Rv0057		Rv0057			
NC_002945.3	Mycobrowser_v4	CDS	545854	546204	.	+	0	Mb0462	Mb0462		CONSERVED HYPOTHETICAL PROTEIN	Mb0462, -, len: 116 aa. Equivalent to Rv0454, len: 116 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 116 aa overlap). Conserved hypothetical protein, showing similarity with AAA63007.1|U15183 hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 151, E(): 0.0019,(31.5% identity in 89 aa overlap).	Q7U1Y8,A0A1R3XVD7	No	conserved hypotheticals			A0A1R3XVD7					Q7U1Y8					Rv0454		Rv0454			
NC_002945.3	Mycobrowser_v4	CDS	25894	26862	.	-	0	Mb0021c	Mb0021c		CONSERVED HYPOTHETICAL PROTEIN	Mb0021c, -, len: 322 aa. Equivalent to Rv0021c,len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 322 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. NP_464341.1|NC_003210 protein similar to oxidoreductases from Listeria monocytogenes (309 aa); NP_357973.1|NC_003098 Enoyl-acyl carrier protein(ACP) reductase from Streptococcus pneumoniae (324 aa); 2NPD_NEUCR|G726338 2-nitropropane dioxygenase precursor from Neurospora crassa (378 aa), FASTA scores: opt: 383,E(): 1.1e-16, (32.2% identity in 348 aa overlap); etc. Also similar to AE001747_25 from Thermotoga maritima section 59 (314 aa), FASTA scores: opt: 442, E(): 1.5e-19,(30.5% identity in 325 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv3553 (355 aa), FASTA scores: E(): 6.8e-15, (35.3 identity in 235 aa overlap); and Rv1533 (375 aa), FASTA scores: E(): 4.7e-12,(34.4% identity in 262 aa overlap).	Q7U302,A0A1R3XU19	No	conserved hypotheticals			A0A1R3XU19				IPR004136,IPR013785	Q7U302					Rv0021c		Rv0021c			
NC_002945.3	Mycobrowser_v4	CDS	41988	42335	.	-	0	Mb0040c	Mb0040c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0040c, -, len: 115 aa. Equivalent to Rv0039c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 115 aa overlap). Possible conserved transmembrane protein, highly similar to NP_301154.1|NC_002677|Z70722|MLCB1770_18 hypothetical protein from Mycobacterium leprae (113 aa), FASTA scores: opt: 492, E(): 7.8e-27, (64.9% identity in 114 aa overlap).	Q7U2Z2,A0A1R3XUB4	No	cell wall and cell processes			A0A1R3XUB4					Q7U2Z2					Rv0039c		Rv0039c			
NC_002945.3	Mycobrowser_v4	CDS	2129311	2129922	.	-	0	Mb1923c	Mb1923c		HYPOTHETICAL PROTEIN	Mb1923c, -, len: 203 aa. Equivalent to Rv1890c,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Hypothetical unknown protein.	Q7TZC7,A0A1R3Y011	No	conserved hypotheticals			A0A1R3Y011				IPR007372	Q7TZC7					Rv1890c		Rv1890c			
NC_002945.3	Mycobrowser_v4	CDS	28343	29176	.	+	0	Mb0024	Mb0024		PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN [FIRST PART]	Mb0024, -, len: 277 aa. Equivalent to 5' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 192 aa overlap). Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477,Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts, Mb0024 and Mb0025.	Q7U300,A0A1R3XU42	No				A0A1R3XU42					Q7U300										
NC_002945.3	Mycobrowser_v4	CDS	28918	29187	.	+	0	Mb0025	Mb0025		PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN [SECOND PART]	Mb0025, -, len: 89 aa. Equivalent to 3' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 aa overlap). Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08,(37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts,Mb0024 and Mb0025.		No																			
NC_002945.3	Mycobrowser_v4	CDS	29225	29587	.	+	0	Mb0026	Mb0026		CONSERVED HYPOTHETICAL PROTEIN	Mb0026, -, len: 120 aa. Equivalent to Rv0025, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 120 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 aa), FASTA score: (37.6% identity in 101 aa overlap), and Rv0026 FASTA score: (35.4% identity in 113 aa overlap); etc.	Q7U2Z9,A0A1R3XU54	No	conserved hypotheticals			A0A1R3XU54				IPR019710	Q7U2Z9					Rv0025		Rv0025			
NC_002945.3	Mycobrowser_v4	CDS	29702	31135	.	+	0	Mb0027	Mb0027		CONSERVED HYPOTHETICAL PROTEIN	Mb0027, -, len: 477 aa. Equivalent to 5' end of Rv0026, len: 448 aa, from Mycobacterium tuberculosis strain H37Rv, (94.4% identity in 449 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis: Rv0025 FASTA score: (35.4% identity in 113 aa overlap) and Rv0739 (268 aa), FASTA score: (32.4% identity in 142 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 4 bp insertion (*-atcg) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa).	Q7U2Z8,A0A1R3XU28	No				A0A1R3XU28				IPR019710	Q7U2Z8										
NC_002945.3	Mycobrowser_v4	CDS	31173	31490	.	+	0	Mb0028	Mb0028		conserved hypothetical protein	Mb0028, -, len: 105 aa. Equivalent to Rv0027, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Hypothetical unknown protein.	X2BDT8,P64668	No	conserved hypotheticals			P64668					X2BDT8					Rv0027		Rv0027			
NC_002945.3	Mycobrowser_v4	CDS	39040	39813	.	-	0	Mb0037c	Mb0037c		conserved protein	Mb0037c, -, len: 257 aa. Equivalent to Rv0036c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Conserved hypothetical protein, highly similar to CAB95889.1|AL359988 conserved hypothetical protein from Streptomyces (276 aa). Also some similarity to Rv3099c|MTCY164_10 (283 aa), FASTA scores: E(): 3.3e-05,(25.9 % identity in 205 aa overlap).	X2BDU5,P64676,P64676	No	conserved hypotheticals			P64676					X2BDU5,P64676					Rv0036c		Rv0036c			
NC_002945.3	Mycobrowser_v4	CDS	39861	41186	.	-	0	Mb0038c	Mb0038c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0038c, -, len: 441 aa. Equivalent to Rv0037c,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of macrolide, showing some similarity to Rv1258c|MTCY50_24 (419 aa), FASTA score: (25.2% identity in 408 aa overlap); and to AL049826|SCH24_20 from Streptomyces coelicolor (425 aa), FASTA scores: opt: 725, E(): 0, (36.1% identity in 418 aa overlap). Also similarity with several MACROLIDE-EFFLUX PROTEINS e.g. from S. pyogenes (405 aa),FASTA scores: E(): 1.3e-06, (22.8% identity in 416 aa overlap).	X2BDU7,P0A5C2,P0A5C2	No	cell wall and cell processes			P0A5C2					X2BDU7,P0A5C2					Rv0037c		Rv0037c			
NC_002945.3	Mycobrowser_v4	CDS	41288	41896	.	+	0	Mb0039	Mb0039		conserved protein	Mb0039, -, len: 202 aa. Equivalent to Rv0038, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein, equivalent to MLCB1770_16|Q50191|Y038_MYCLE hypothetical 22.0 kDa from Mycobacterium leprae (202 aa), FASTA scores: opt: 1194,E(): 0, (88.6% identity in 202 aa overlap). Also highly similar or similar to other hypothetical proteins e.g. CAB72194.1|AL138851|SCE59.07c from Streptomyces coelicolor (193 aa); AAC06288.1|AF050466 from Mycobacterium bovis (82 aa) (similarity in N-terminus); NP_224347.1|NC_000922|YqgE from Chlamydophila pneumoniae (188 aa); YQGE_ECOLI HYPOTHETICAL 20.7 KD PROTEIN (187 aa), FASTA score: (29.5% identity in 166 aa overlap); etc.	X2BDV3,P67758	No	conserved hypotheticals			P67758					X2BDV3					Rv0038		Rv0038			
NC_002945.3	Mycobrowser_v4	CDS	46565	47191	.	-	0	Mb0043c	Mb0043c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MARR-FAMILY)	Mb0043c, -, len: 208 aa. Equivalent to Rv0042c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Possible transcriptional regulatory protein, MarR-family, highly similar except in N-terminus to CAC32228.1|AL583926 putative MarR-family regulatory protein from Mycobacterium leprae (243 aa). Also similar in part to others e.g. AB76343.1|AL158061 putative MarR-family transcriptional regulator from Streptomyces coelicolor (163 aa); NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (164 aa); NP_531782.1|NC_003304 transcriptional regulator, MarR family from Agrobacterium tumefaciens (151 aa); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv2327, Rv0880, and Rv1404.	Q7U2Z1,A0A1R3XU39	No	regulatory proteins			A0A1R3XU39				IPR000835,IPR011991	Q7U2Z1					Rv0042c		Rv0042c			
NC_002945.3	Mycobrowser_v4	CDS	241710	242120	.	+	0	Mb0209	Mb0209		POSSIBLE EXPORTED PROTEIN	Mb0209, -, len: 136 aa. Equivalent to Rv0203, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Possible exported protein (has hydrophobic stretch near N-terminus). Some similarity to part of U02459|LDU02459_1 hypothetical protein from Leishmania donovani (741 aa), FASTA score: opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap).	Q7U2K8,A0A1R3XUT6	No	cell wall and cell processes			A0A1R3XUT6					Q7U2K8					Rv0203		Rv0203			
NC_002945.3	Mycobrowser_v4	CDS	47350	48084	.	-	0	Mb0044c	Mb0044c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY)	Mb0044c, -, len: 244 aa. Equivalent to Rv0043c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable transcriptional regulator, GntR family, similar to others e.g. NP_420584.1|NC_002696 transcriptional regulator GntR family from Caulobacter crescentus (221 aa); NP_294539.1|NC_001263 transcriptional regulator GntR family from Deinococcus radiodurans (267 aa); YIN1_STRAM|P32425 hypothetical transcriptional regulatory protein from Streptomyces ambofaciens (236 aa), FASTA scores: opt: 170, E(): 9.8e-05, (27.6% identity in 127 aa overlap); etc. Similar also to SC9B10_7 from Streptomyces coelicolor FASTA score: E():0.00038; and Rv0165c|MTCI28_5 from Mycobacterium tuberculosis (264 aa), FASTA score: (27.7% identity in 130 aa overlap).	X2BDV8,P67738,P67738	No	regulatory proteins			P67738					X2BDV8,P67738					Rv0043c		Rv0043c			
NC_002945.3	Mycobrowser_v4	CDS	48217	49011	.	-	0	Mb0045c	Mb0045c		POSSIBLE OXIDOREDUCTASE	Mb0045c, -, len: 264 aa. Equivalent to Rv0044c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar to AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase from Streptomyces lavendulae (264 aa). Also similar to Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c,Rv0791c, Rv0132c, etc.	Q7U2Z0,A0A1R3XU55	No	intermediary metabolism and respiration			A0A1R3XU55				IPR011251,IPR022480	Q7U2Z0					Rv0044c		Rv0044c			
NC_002945.3	Mycobrowser_v4	CDS	546394	546840	.	-	0	Mb0463c	Mb0463c		conserved protein	Mb0463c, -, len: 148 aa. Equivalent to Rv0455c,len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Conserved hypothetical protein, equivalent to CAC31896.1|AL583925 possible secreted protein from Mycobacterium leprae (153 aa). Has hydrophobic stretch at N-terminus.	Q7U1Y7,A0A1R3XVF9	No	conserved hypotheticals			A0A1R3XVF9				IPR021357	Q7U1Y7					Rv0455c		Rv0455c			
NC_002945.3	Mycobrowser_v4	CDS	49027	49923	.	-	0	Mb0046c	Mb0046c		POSSIBLE HYDROLASE	Mb0046c, -, len: 298 aa. Equivalent to Rv0045c, len 298 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 298 aa overlap). Possible hydrolase (EC 3.-.-.-), showing similarity with others eg NP_107230.1|NC_002678 putative hydrolase from Mesorhizobium loti (278 aa); CAB56730.1|AL121600 putative hydrolase from Streptomyces coelicolor (302 aa); NP_438361.1|NC_000907 putative esterase/lipase from Haemophilus influenzae Rd (287 aa); etc. Also similar to Mycobacterium tuberculosis proteins Rv3473c, Rv1123c,Rv1938, Rv3617, Rv3670, etc.	Q7U2Y9,A0A1R3XU63	No	lipid metabolism			A0A1R3XU63				IPR000073	Q7U2Y9					Rv0045c		Rv0045c			
NC_002945.3	Mycobrowser_v4	CDS	1287656	1287940	.	-	0	Mb1191c	Mb1191c		unknown protein	Mb1191c, -, len: 94 aa. Equivalent to Rv1159A, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Hypothetical unknown protein.	X2BH61,P0A5S3,P0A5S3	No	conserved hypotheticals			P0A5S3					X2BH61,P0A5S3					Rv1159A		Rv1159A			
NC_002945.3	Mycobrowser_v4	CDS	364523	364825	.	+	0	Mb0307	Mb0307		HYPOTHETICAL PROTEIN	Mb0307, -, len: 100 aa. Equivalent to Rv0299, len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 100 aa overlap). Hypothetical unknown protein. Equivalent to AAK44536.1 from Mycobacterium tuberculosis strain CDC1551 (49 aa) but longer 51 aa.	Q7U2B8,A0A1R3XUX9	No	conserved hypotheticals			A0A1R3XUX9					Q7U2B8					Rv0299		Rv0299			
NC_002945.3	Mycobrowser_v4	CDS	51169	51711	.	-	0	Mb0048c	Mb0048c		conserved protein	Mb0048c, -, len: 180 aa. Equivalent to Rv0047c,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 180 aa overlap). Conserved hypothetical protein, equivalent to NP_302717.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (180 aa). Also showing strong similarity to other hypothetical proteins e.g. AL049826|SCH24_22|T36587 from Streptomyces coelicolor (225 aa), FASTA scores: opt: 583,E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some similarity to Rv1176c from Mycobacterium tuberculosis and to P94443|YFIO from Bacillus subtilis (182 aa), FASTA scores: E(): 0.00066, (24.9% identity in 177 aa overlap). Also some similarity to G1163121 MITHRAMYCIN RESISTANCE DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores: opt: 143, E(): 0.0091, (29.4% identity in 180 aa overlap).	Q7U2Y8,A0A1R3XWC5	No	conserved hypotheticals			A0A1R3XWC5				IPR005149,IPR011991	Q7U2Y8					Rv0047c		Rv0047c			
NC_002945.3	Mycobrowser_v4	CDS	55686	57368	.	+	0	Mb0052	Mb0052		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0052, -, len: 560 aa. Equivalent to Rv0051,len:560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable conserved transmembrane protein, equivalent to NP_302714.1|NC_002677 conserved membrane protein from Mycobacterium leprae (564 aa); and highly similar to C-terminus of AAF25828.1|AF187306_1|AF187306 putative transmembrane protein from Mycobacterium smegmatis (692 aa). Also highly similar to MSGDNAB_5|G886306|L222-ORF5 (418 aa), FASTA scores: opt: 2163, E(): 0, (78.4% identity in 412 aa overlap). Also similar to AL049826|SCH24_24|T36589 probable transmembrane protein from Streptomyces coelicolor (502 aa), FASTA scores: opt: 492, E(): 1.4e-23,(35.8% identity in 522 aa overlap).	Q7U2Y5,A0A1R3XU43	No	cell wall and cell processes			A0A1R3XU43				IPR016570,IPR018584	Q7U2Y5					Rv0051		Rv0051			
NC_002945.3	Mycobrowser_v4	CDS	57400	57963	.	+	0	Mb0053	Mb0053		conserved protein	Mb0053, -, len: 187 aa. Equivalent to Rv0052, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Conserved hypothetical protein, similar to others e.g. AL049587|SC5F2A_30S|T35272 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 531,E(): 3.4e-29, (49.5% identity in 182 aa overlap); NP_420588.1|NC_002696 ThiJ/PfpI family protein from Caulobacter crescentus (267 aa); etc. Some similarity to Escherichia coli G1100872|thiJ (198 aa), FASTA scores: opt: 178, E(): 6.1e-06, (29.9% identity in 137 aa overlap). Also similar to Rv1930c from Mycobacterium tuberculosis (174 aa). May be a membrane protein.	Q7U2Y4,A0A1R3XU47	No	conserved hypotheticals			A0A1R3XU47				IPR025628	Q7U2Y4					Rv0052		Rv0052			
NC_002945.3	Mycobrowser_v4	CDS	63190	63882	.	+	0	Mb0060	Mb0060		HYPOTHETICAL PROTEIN	Mb0060, -, len: 230 aa. Equivalent to Rv0059, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Hypothetical unknown protein.	Q7U2Y3,A0A1R3XUE0	No	conserved hypotheticals			A0A1R3XUE0					Q7U2Y3					Rv0059		Rv0059			
NC_002945.3	Mycobrowser_v4	CDS	63899	64957	.	+	0	Mb0061	Mb0061		CONSERVED HYPOTHETICAL PROTEIN	Mb0061, -, len: 352 aa. Equivalent to Rv0060, len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein, showing weak similarity to NP_104623.1|NC_002678 hypothetical protein from Mesorhizobium loti (155 aa); and AP000062|AP000062_92 hypothetical protein from Aeropyrum pernix (194 aa), FASTA scores: opt: 186, E(): 4.2e-05, (30.9% identity in 165 aa overlap).	Q7U2Y2,A0A1R3XUT5	No	conserved hypotheticals			A0A1R3XUT5				IPR002589	Q7U2Y2					Rv0060		Rv0060			
NC_002945.3	Mycobrowser_v4	CDS	65002	65340	.	-	0	Mb0062A	Mb0062A		Hypothetical protein	Mb0062A, len: 112 aa. Equivalent to Rv0061c len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein supported by RNA-seq data. Similar to MMAR_3839, 76% identity in 112 aa overlap. Replaces questionable ORF Rv0061 (MTV030.04).	X2BDW9,A0A1R3XU77	No	conserved hypotheticals			A0A1R3XU77					X2BDW9					Rv0061c		Rv0061c			
NC_002945.3	Mycobrowser_v4	CDS	309099	309842	.	-	0	Mb0265c	Mb0265c		CONSERVED HYPOTHETICAL PROTEIN	Mb0265c, -, len: 247 aa. Equivalent to Rv0259c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 247 aa overlap). Conserved hypothetical protein, showing some similarity to Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis (281 aa), FASTA scores: E(): 9.5e-16, (33.6 % identity in 235 aa overlap). Also some similarity with CAC33938.1|AL589708 putative secreted protein from Streptomyces coelicolor (248 aa).	Q7U2F6,A0A1R3XUU8	No	conserved hypotheticals			A0A1R3XUU8				IPR002762	Q7U2F6					Rv0259c		Rv0259c			
NC_002945.3	Mycobrowser_v4	CDS	66913	68352	.	+	0	Mb0064	Mb0064		POSSIBLE OXIDOREDUCTASE	Mb0064, -, len: 479 aa. Equivalent to Rv0063, len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase from Arthrobacter oxidans (458 aa), FASTA scores: opt: 343,E(): 3.4e-13, (27.4% identity in 467 aa overlap); AAD28454.1|AF127374_9|AF127374|MitR oxidase from Streptomyces lavendulae (514 aa); AAF81732.1|AF254925|EncM putative FAD-dependent oxygenase from Streptomycesmaritimus (464 aa); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3107c, Rv1257c,etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.	Q7U2X9,A0A1R3XU80	No	intermediary metabolism and respiration			A0A1R3XU80				IPR006093,IPR006094,IPR006311,IPR012951,IPR016166,IPR016167,IPR016169	Q7U2X9					Rv0063		Rv0063			
NC_002945.3	Mycobrowser_v4	CDS	68610	71549	.	+	0	Mb0065	Mb0065		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0065, -, len: 979 aa. Equivalent to Rv0064, len: 979 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 979 aa overlap). Probable conserved transmembrane protein, highly similar to NP_301532.1| (NC_002677) putative integral membrane protein from Mycobacterium leprae (983 aa). Also similar to other hypothetical proteins from ARCHAEOGLOBUS FULGIDUS and Synecocystis sp. e.g. P72637|D90899 HYPOTHETICAL 117.2 KD PROTEIN from SYNECHOCYSTIS SP. (1032 aa), FASTA scores: opt: 1004, E(): 3.6e-32, (31.0 % identity in 848 aa overlap); and CAC01334.1|AL390968 putative integral membrane protein (fragment) from Streptomyces coelicolor (815 aa); etc. Also similar to Rv3193c from Mycobacterium tuberculosis (992 aa), FASTA score: (50.3% identity in 985 aa overlap). Contains probable coiled-coil domain from aa 948 to 976.	X2BDX2,Q7U2X8,Q7U2X8	No	cell wall and cell processes			Q7U2X8					X2BDX2,Q7U2X8					Rv0064		Rv0064			
NC_002945.3	Mycobrowser_v4	CDS	74656	75225	.	-	0	Mb0068c	Mb0068c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)	Mb0068c, -, len: 189 aa. Equivalent to Rv0067c,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 189 aa overlap). Possible transcriptional regulator, highly similar except in N-terminus to T44726 probable transcription regulator from Mycobacterium leprae (189 aa), FASTA scores: opt: 829,E(): 0, (68.3% identity in 189 aa overlap). And similar to others, often many members of the tetR family, e.g. T36918 probable transcription regulator from Streptomyces coelicolor (202 aa); NP_535866.1|NC_003306 transcriptional regulator TetR family from Agrobacterium tumefaciens strain C58 (Dupont) (194 aa); UIDR_ECOLI|Q59431 uid operon repressor (gus operon repressor) from Escherichia coli (196 aa), FASTA scores: opt: 200, E(): 7.2e-06, (24.7% identity in 186 aa overlap); etc. Also similar to MTCY8D5_28 from Mycobacterium tuberculosis cosmid (229 aa), FASTA score: (32.7% identity in 168 aa overlap). Contains probable helix-turn-helix motif from aa 34 to 55 (Score 1523, +4.37 SD).	Q7U2X5,A0A1R3XVC8	No	regulatory proteins			A0A1R3XVC8				IPR001647,IPR009057,IPR011075,IPR015893	Q7U2X5					Rv0067c		Rv0067c			
NC_002945.3	Mycobrowser_v4	CDS	75328	76239	.	+	0	Mb0069	Mb0069		PROBABLE OXIDOREDUCTASE	Mb0069, -, len: 303 aa. Equivalent to Rv0068, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Probable oxidoreductase (EC 1.-.-.-), equivalent to NP_301343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (304 aa). Also highly similar to many e.g. NP_485762.1|NC_003272 probable oxidoreductase from Nostoc sp. PCC 7120 (311 aa); NP_279536.1|NC_002607|YajO1 probable oxidoreductase from Halobacterium sp. NRC-1 (316 aa); OXIR_STRAT|Q03326 probable oxidoreductase from Streptomyces antibioticus (298 aa), FASTA scores: opt: 430, E(): 1.3e-16, (34.9% identity in 295 aa overlap); etc. Also highly similar to MTV037_3 and MTV022_13 from Mycobacterium tuberculosis.	Q7U2X4,A0A1R3XUE4	No	intermediary metabolism and respiration			A0A1R3XUE4				IPR002198,IPR002347,IPR016040	Q7U2X4					Rv0068		Rv0068			
NC_002945.3	Mycobrowser_v4	CDS	89610	89954	.	+	0	Mb0084	Mb0084		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0084, -, len: 114 aa. Equivalent to Rv0081, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Probable transcriptional regulator, highly similar to others e.g. AL078610|SCH35_52|T36657 probable transcription regulator from Streptomyces coelicolor (117 aa), FASTA scores: opt: 404, E(): 4.8e-22, (58.2% identity in 110 aa overlap); AAG02351.1|AF210249_10|AF210249 metal-dependent regulatory protein from Streptomyces verticillus (113 aa); NP_435817.1|NC_003037 Putative transcriptional regulator from Sinorhizobium meliloti (115 aa); etc.	Q7U2W1,A0A1R3XUB3	No	regulatory proteins			A0A1R3XUB3				IPR001845,IPR011991	Q7U2W1					Rv0081		Rv0081			
NC_002945.3	Mycobrowser_v4	CDS	103745	104698	.	-	0	Mb0097c	Mb0097c		CONSERVED HYPOTHETICAL PROTEIN	Mb0097c, -, len: 317 aa. Equivalent to Rv0094c,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(97.8% identity in 317 aa overlap). Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (49.4% identity in 79 aa overlap).	Q7U2V3,A0A1R3XVG7	No	insertion seqs and phages			A0A1R3XVG7				IPR003615,IPR003870	Q7U2V3					Rv0094c		Rv0094c			
NC_002945.3	Mycobrowser_v4	CDS	79513	80229	.	+	0	Mb0072	Mb0072		POSSIBLE MATURASE	Mb0072, -, len: 238 aa. Equivalent to Rv0071, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 238 aa overlap). Possible maturase,similar to many proteins of the group II intron maturase family e.g. P95451|U77945 MATURASE-RELATED PROTEIN from PSEUDOMONAS ALCALIGENES (297 aa), FASTA scores: opt: 395,E(): 1.7e-20, (43.5% identity in 147 aa overlap); N-terminus of AAD16434.1|AF101076 maturase-related protein from Pseudomonas putida (473 aa); N-terminus of NP_437373.1|NC_003078 putative reverse transcriptasematurase protein from Sinorhizobium meliloti (453 aa); etc. Also similar to MLCL581_1 from Mycobacterium leprae. Contains 5 VDP repeats at N-terminus, these are also found in two Streptococcus plasmid hypothetical proteins Q52246|X17092 and Q54942|X66468. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp insertion (*-cggtggacc) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (238 aa versus 235 aa).	Q7U2X2,A0A1R3XU78	No	information pathways			A0A1R3XU78				IPR000477	Q7U2X2					Rv0071		Rv0071			
NC_002945.3	Mycobrowser_v4	CDS	80660	81709	.	+	0	Mb0073	Mb0073		PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER	Mb0073, -, len: 349 aa. Equivalent to Rv0072, len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Probable glutamine-transport transmembrane protein ABC-transporter (see citation below), showing weak similarity to NP_465894.1|NC_003210 protein similar to putative ABC-transporter transmembrane subunit from Listeria monocytogenes EGD-e (367 aa); NP_471800.1|NC_003212 protein similar to putative ABC-transporter transmembrane subunit from Listeria innocua (367 aa); E1204111|AJ003195 MEMBRANE SPANNING SUBUNIT DEVC from ANABAENA VARIABILIS (385 aa), FASTA scores: opt: 155, E(): 8.1e-07, (22.0% identity in 381 aa overlap). Also highly similar to Rv2563|Y0A5_MYCTU|Q50735|MTCY9C4.05c from Mycobacterium tuberculosis (388 aa), FASTA scores: E(): 0, (76.2% identity in 349 aa overlap). Note that supposed act with near ORF Rv0073|MTV030.17 ATP-binding protein ABC-transporter.	Q7U2X1,A0A1R3XU95	No	cell wall and cell processes			A0A1R3XU95				IPR003838,IPR025857	Q7U2X1					Rv0072		Rv0072			
NC_002945.3	Mycobrowser_v4	CDS	167461	167871	.	-	0	Mb0146c	Mb0146c		unknown protein	Mb0146c, -, len: 136 aa. Equivalent to Rv0141c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Hypothetical unknown protein.	Q7U2R7,A0A1R3XUH7	No	conserved hypotheticals			A0A1R3XUH7				IPR009959	Q7U2R7					Rv0141c		Rv0141c			
NC_002945.3	Mycobrowser_v4	CDS	81712	82554	.	+	0	Mb0074	Mb0074		PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER GLNQ	Mb0074, -, len: 280 aa. Equivalent to 5' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (94.9% identity in 275 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075.	Q7U2X0,A0A1R3XU83	No				A0A1R3XU83				IPR000595,IPR003439,IPR003593,IPR014710,IPR017871,IPR018490,IPR027417	Q7U2X0										
NC_002945.3	Mycobrowser_v4	CDS	82491	82703	.	+	0	Mb0075	Mb0075		PROBABLE GLUTAMINE-TRANSPORT PROTEIN ABC TRANSPORTER GLNQ	Mb0075, -, len: 70 aa. Equivalent to 3' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 70 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075.		No																			
NC_002945.3	Mycobrowser_v4	CDS	86563	87168	.	+	0	Mb0080	Mb0080		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0080, -, len: 201 aa. Equivalent to Rv0078, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Probable transcriptional regulator, equivalent to NP_302706.1|NC_002677 putative TetR-family transcriptional regulator from Mycobacterium leprae (236 aa), FASTA scores: opt: 755, E(): 0, (71.4% identity in 175 aa overlap). Also similar to others e.g. NP_103770.1|NC_002678 probable transcriptional regulator from Mesorhizobium loti (208 aa); NP_384275.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (197 aa); NP_250960.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (196 aa); etc. Also similar to TETC_ECOLI|P28815 transposon tn10 tetc protein from Escherichia coli (197 aa), FASTA scores: opt: 181, E(): 9.7e-05, (24.8% identity in 165 aa overlap). Contains probable helix-turn-helix motif from aa 35 to 56 (Score 1348, +3.78 SD).	Q7U2W5,A0A1R3XUV6	No	regulatory proteins			A0A1R3XUV6				IPR001647,IPR009057,IPR011075,IPR015893	Q7U2W5					Rv0078		Rv0078			
NC_002945.3	Mycobrowser_v4	CDS	87833	88039	.	-	0	Mb0081A	Mb0081A		Conserved protein	Mb0081A, len: 68 aa. Equivalent to Rv0078B len: 68 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 68 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BDY8,A0A1R3XU82	No	conserved hypotheticals			A0A1R3XU82					X2BDY8					Rv0078B		Rv0078B			
NC_002945.3	Mycobrowser_v4	CDS	88239	89060	.	+	0	Mb0082	Mb0082		unknown protein	Mb0082, -, len: 273 aa. Equivalent to Rv0079, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Hypothetical unknown protein.	Q7U2W3,A0A1R3XUA4	No	conserved hypotheticals			A0A1R3XUA4					Q7U2W3					Rv0079		Rv0079			
NC_002945.3	Mycobrowser_v4	CDS	89057	89515	.	+	0	Mb0083	Mb0083		CONSERVED HYPOTHETICAL PROTEIN	Mb0083, -, len: 152 aa. Equivalent to Rv0080, len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 152 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Streptomyces coelicolor e.g. SCJ12.26|AL109989|SCJ12_24 from Streptomyces coelicolor cosmid J1 (137 aa), FASTA scores: opt: 291, E(): 4e-13, (46.5% identity in 129 aa overlap); etc.	Q7U2W2,A0A1R3XU92	No	conserved hypotheticals			A0A1R3XU92				IPR012349,IPR024747	Q7U2W2					Rv0080		Rv0080			
NC_002945.3	Mycobrowser_v4	CDS	89959	90438	.	+	0	Mb0085	Mb0085		PROBABLE OXIDOREDUCTASE	Mb0085, -, len: 159 aa. Equivalent to Rv0082, len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 159 aa overlap). Probable oxidoreductase (EC 1.-.-.-), highly highly similar or similar to other various oxidoreductases e.g. NP_143304.1|NC_000961 NADH-ubiquinone oxidoreductase subunit from Pyrococcus horikoshii (173 aa); NP_126406.1|NC_000868 CO-induced hydrogenase related,subunit L from Pyrococcus abyssi (170 aa); HYCG_ECOLI|P16433 formate hydrogenlyase subunit 7 from Escherichia coli (255 aa), FASTA scores: opt: 442, E(): 8e-29, (43.2% identity in 148 aa overlap); etc.	Q7U2W0,A0A1R3XUA1	No	intermediary metabolism and respiration			A0A1R3XUA1				IPR006137	Q7U2W0					Rv0082		Rv0082			
NC_002945.3	Mycobrowser_v4	CDS	90435	92363	.	+	0	Mb0086	Mb0086		PROBABLE OXIDOREDUCTASE	Mb0086, -, len: 642 aa. Equivalent to Rv0083, len: 640 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 640 aa overlap). Probable oxidoreductase (EC 1.-.-.-), showing some similarity to other various oxidoreductases e.g. AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa); HYFB_ ECOLI|P23482 hydrogenase-4 component b from Escherichia coli strain K12 (672 aa), FASTA scores: opt: 995, E(): 0,(32.2% identity in 571 aa overlap); AAF13041.1|AF157639_1|AF157639 putative formate hydrogenlyase integral membrane subunit from Desulfitobacterium dehalogenans (637 aa); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa).	Q7U2V9,A0A1R3XWF8	No	intermediary metabolism and respiration			A0A1R3XWF8				IPR001750,IPR003918	Q7U2V9					Rv0083		Rv0083			
NC_002945.3	Mycobrowser_v4	CDS	162834	163439	.	-	0	Mb0140c	Mb0140c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0140c, -, len: 201 aa. Equivalent to Rv0135c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Possible transcriptional regulator, weakly similar to others e.g. P32398|YHGD_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Bacillus subtilis (191 aa), FASTA scores: opt: 145,E(): 0.0012, (21.0% identity in 162 aa overlap).	Q7U2S1,A0A1R3XUL9	No	regulatory proteins			A0A1R3XUL9				IPR001647,IPR009057,IPR015893	Q7U2S1					Rv0135c		Rv0135c			
NC_002945.3	Mycobrowser_v4	CDS	97793	98386	.	+	0	Mb0092	Mb0092		POSSIBLE METHYLTRANSFERASE/METHYLASE	Mb0092, -, len: 197 aa. Equivalent to Rv0089, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Possible methyltransferase (EC 2.1.1.-), showing some weak similarity to others e.g. NP_299749.1|NC_002488 3-demethylubiquinone-9 3-methyltransferase from Xylella fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative methyltransferase from Streptomyces coelicolor (285 aa); NP_111415.1|NC_002689 Predicted SAM-dependent methyltransferase from Thermoplasma volcanium (245 aa); etc. Also some similarity with many biotin biosynthesis proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY.	X2BE12,P65347,P65347	No	intermediary metabolism and respiration			P65347					X2BE12,P65347					Rv0089		Rv0089			
NC_002945.3	Mycobrowser_v4	CDS	104469	105251	.	-	0	Mb0098c	Mb0098c		CONSERVED HYPOTHETICAL PROTEIN	Mb0098c, -, len: 260 aa. Equivalent to Rv1588 and Rv0095c, len: 222 aa and 136 aa, from Mycobacterium tuberculosis strain H37Rv, (98.2% identity in 222 aa overlap and 92.5% identity in 134 aa overlap). Member of 13E12 repeat, also partially similar to AF0418|AF041819_8 from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% identity in 96 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis, a 73 bp substitution leads to a single combined gene.	Q7U2V2,A0A1R3XUI1	No				A0A1R3XUI1				IPR003870	Q7U2V2					Rv1588		Rv1588			
NC_002945.3	Mycobrowser_v4	CDS	2265207	2265530	.	+	0	Mb2060	Mb2060		arsr repressor protein	Mb2060, -, len: 107 aa. Equivalent to Rv2034, len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 107 aa overlap). Probable repressor protein similar to several belonging to the ARSR FAMILY e.g. Q53040 (112 aa). FASTA scores: sptr|Q53040|Q53040 NITRILE HYDRATASE REGULATAR 2 (112 aa) opt: 167, E( ): 6.7e-06; 44.7% identity in 76 aa overlap. TBparse score is 0.905. Contains probable helix-turn-helix at aa 32-53 (S core 1350, +3.78 SD)	Q7VES9,A0A1R3Y0E0	No	regulatory proteins			A0A1R3Y0E0				IPR001845,IPR011991	Q7VES9					Rv2034		Rv2034			
NC_002945.3	Mycobrowser_v4	CDS	106770	107639	.	+	0	Mb0100	Mb0100		POSSIBLE OXIDOREDUCTASE	Mb0100, -, len: 289 aa. Equivalent to Rv0097, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to NP_302343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (289 aa). Also highly similar to BAB69377.1|AB070955 putative oxidoreductase from Streptomyces avermitilis (296 aa); and weakly similar to others e.g. NP_518867.1|NC_003295 PUTATIVE ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE OXIDOREDUCTASE PROTEIN from Ralstonia solanacearum (301 aa); NP_286110.1|NC_002655 taurine dioxygenase (2-oxoglutarate-dependent) from Escherichia coli strain O157:H7 (283 aa); NP_252624.1|NC_002516 taurine dioxygenase from Pseudomonas aeruginosa (277 aa); ECAE00014310 (283 aa), FASTA scores: opt: 304, E(): 2.6e-13, (27.8% identity in 288 aa overlap); TFDA_ALCEU|P10088 2,4-dichlorophenoxyacetate monooxygenase from A. eutropha (287 aa), FASTA scores: opt: 188, E(): 3.5e-06, (26.6% identity in 188 aa overlap); etc. Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature.	X2BE10,P67756,P67756	No	intermediary metabolism and respiration			P67756					X2BE10,P67756					Rv0097		Rv0097			
NC_002945.3	Mycobrowser_v4	CDS	122353	123867	.	+	0	Mb0107	Mb0107		CONSERVED HYPOTHETICAL PROTEIN	Mb0107, -, len: 504 aa. Equivalent to Rv0104, len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 504 aa overlap). Conserved hypothetical protein, showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta regulatory subunit from Homo sapiens (380 aa); etc.	Q7U2U8,A0A1R3XVH4	No	conserved hypotheticals			A0A1R3XVH4				IPR000595,IPR014710,IPR016040,IPR018490	Q7U2U8					Rv0104		Rv0104			
NC_002945.3	Mycobrowser_v4	CDS	109819	110055	.	+	0	Mb0103	Mb0103		CONSERVED HYPOTHETICAL PROTEIN	Mb0103, -, len: 78 aa. Equivalent to Rv0100,(MTCY251.19), len: 78 aa. Conserved hypothetical protein,equivalent only to CAC30950.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (78 aa).	X2BE11,P64688	No				P64688					X2BE11										
NC_002945.3	Mycobrowser_v4	CDS	117750	119735	.	+	0	Mb0105	Mb0105		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0105, -, len: 661 aa. Equivalent to Rv0102, len: 661 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 661 aa overlap). Probable conserved integral membrane protein, highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium leprae (659 aa), FASTA scores: opt: 3107, E(): 0, (70.2% identity in 662 aa overlap). Also similar to others e.g. CAC01497.1|AL391017 putative integral membrane protein from Streptomyces coelicolor (316 aa); etc. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.	X2BE16,P64690,P64690	No	cell wall and cell processes			P64690					X2BE16,P64690					Rv0102		Rv0102			
NC_002945.3	Mycobrowser_v4	CDS	124410	125606	.	+	0	Mb0109	Mb0109		CONSERVED HYPOTHETICAL PROTEIN	Mb0109, -, len: 398 aa. Equivalent to Rv0106, len: 398 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 398 aa overlap). Conserved hypothetical protein, similar to others e.g. AL049841|SCE9_33 from Streptomyces coelicolor (370 aa),FASTA scores: opt: 282, E(): 2.5e-11, (32.0% identity in 381 aa overlap); etc. Some similarity to P94400 HOMOLOGUE TO NITRILE HYDRATASE REGION from Bacillus subtilis (397 aa), FASTA scores: opt: 226, E(): 5.4e-08, (26.4% identity in 405 aa overlap). Also similar to COBW_PSEDE|P29937 FASTA score: (25.3% identity in 186 aa overlap); and P47K_PSECL|P31521 47 kd protein (p47k) (419 aa), FASTA score: (25.9% identity in 401 aa overlap).	X2BE15,P64692	No	conserved hypotheticals			P64692					X2BE15					Rv0106		Rv0106			
NC_002945.3	Mycobrowser_v4	CDS	704058	704444	.	+	0	Mb0623	Mb0623		HYPOTHETICAL PROTEIN	Mb0623, -, len: 128 aa. Equivalent to Rv0607, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Hypothetical unknown protein.	Q7U1M9,A0A1R3XVV1	No	conserved hypotheticals			A0A1R3XVV1					Q7U1M9					Rv0607		Rv0607			
NC_002945.3	Mycobrowser_v4	CDS	1052011	1052784	.	-	0	Mb0966c	Mb0966c		CONSERVED HYPOTHETICAL PROTEIN	Mb0966c, -, len: 257 aa. Equivalent to Rv0941c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Conserved hypothetical protein, showing some similarity with parts of several hypothetical proteins from Streptomyces coelicolor e.g. AL035161|SC9C7_20 (860 aa), FASTA scores: opt: 197, E(): 2.6e-05, (34.2% identity in 114 aa overlap).	Q7U0Z5,A0A1R3XWX7	No	conserved hypotheticals			A0A1R3XWX7				IPR002645	Q7U0Z5					Rv0941c		Rv0941c			
NC_002945.3	Mycobrowser_v4	CDS	130932	131141	.	-	0	Mb0112c	Mb0112c		HYPOTHETICAL PROTEIN	Mb0112c, -, len: 69 aa. Equivalent to Rv0108c, len: 69 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 69 aa overlap). Hypothetical unknown protein.	Q7U2U6,A0A1R3XUC5	No	conserved hypotheticals			A0A1R3XUC5					Q7U2U6					Rv0108c		Rv0108c			
NC_002945.3	Mycobrowser_v4	CDS	383909	384571	.	-	0	Mb0322c	Mb0322c		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb0322c, -, len: 220 aa. Equivalent to Rv0314c,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 220 aa overlap). Possible conserved membrane protein, with hydrophobic stretch from residues ~75-100. Similar in C-terminal part to Mycobacterium tuberculosis proteins Rv0679c and Rv0680c.	Q7U2A3,A0A1R3XUZ4	No	cell wall and cell processes			A0A1R3XUZ4				IPR021417	Q7U2A3					Rv0314c		Rv0314c			
NC_002945.3	Mycobrowser_v4	CDS	167901	168827	.	+	0	Mb0147	Mb0147		CONSERVED HYPOTHETICAL PROTEIN	Mb0147, -, len: 308 aa. Equivalent to Rv0142, len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa).	Q7U2R6,A0A1R3XUH1	No	conserved hypotheticals			A0A1R3XUH1				IPR011257	Q7U2R6					Rv0142		Rv0142			
NC_002945.3	Mycobrowser_v4	CDS	133058	133807	.	+	0	Mb0114	Mb0114		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0114, -, len: 249 aa. Equivalent to Rv0110, len 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Probable conserved integral membrane protein, similar to many e.g. AL079308|SCH69_25 from Streptomyces coelicolor (297 aa),FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity in 251 aa overlap); P54493|YQGP_BACSU HYPOTHETICAL 56.4 KD PROTEIN from Bacillus subtilis (507 aa), FASTA scores: opt: 320, E(): 4e-15, (32.4% identity in 210 aa overlap); etc.	Q7U2U4,A0A1R3XUC1	No	cell wall and cell processes			A0A1R3XUC1				IPR002610,IPR022764	Q7U2U4					Rv0110		Rv0110			
NC_002945.3	Mycobrowser_v4	CDS	133988	136045	.	+	0	Mb0115	Mb0115		POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE	Mb0115, -, len: 685 aa. Equivalent to Rv0111, len: 685 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 685 aa overlap). Possible transmembrane acyltransferase (EC 2.3.1.-), equivalent to AA22904.1|AL035300 putative acyltransferase from Mycobacterium leprae (696 aa). Also similar to others e.g. C69975 acyltransferase homolog yrhL from Bacillus subtilis (634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4% identity in 382 aa overlap). Very similar to Mycobacterium tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc.	Q7U2U3,A0A1R3XUF5	No	intermediary metabolism and respiration			A0A1R3XUF5				IPR002656,IPR013831	Q7U2U3					Rv0111		Rv0111			
NC_002945.3	Mycobrowser_v4	CDS	161060	161665	.	+	0	Mb0138	Mb0138		gcn5-related n-acetyltransferase	Mb0138, -, len: 201 aa. Equivalent to Rv0133, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Putative acetyltransferase (EC 2.3.1.-), highly similar to others e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 aa), FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity in 201 aa overlap).	Q7U2S2,A0A1R3XVK3	No	intermediary metabolism and respiration			A0A1R3XVK3				IPR000182,IPR016181	Q7U2S2					Rv0133		Rv0133			
NC_002945.3	Mycobrowser_v4	CDS	250316	251794	.	+	0	Mb0216	Mb0216		HYPOTHETICAL PROTEIN	Mb0216, -, len: 492 aa. Equivalent to Rv0210, len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381.	Q7U2K2,A0A1R3XUN6	No	conserved hypotheticals			A0A1R3XUN6					Q7U2K2					Rv0210		Rv0210			
NC_002945.3	Mycobrowser_v4	CDS	147946	148380	.	-	0	Mb0126c	Mb0126c		conserved protein	Mb0126c, -, len: 144 aa. Equivalent to Rv0121c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Conserved hypothetical protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155,Rv1875, Rv2074, etc.	Q7U2T3,A0A1R3XUF3	No	conserved hypotheticals			A0A1R3XUF3				IPR011576,IPR012349,IPR019967	Q7U2T3					Rv0121c		Rv0121c			
NC_002945.3	Mycobrowser_v4	CDS	148529	148897	.	+	0	Mb0127	Mb0127		HYPOTHETICAL PROTEIN	Mb0127, -, len: 122 aa. Equivalent to Rv0122, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical unknown protein.	Q7U2T2,A0A1R3XWJ8	No	conserved hypotheticals			A0A1R3XWJ8					Q7U2T2					Rv0122		Rv0122			
NC_002945.3	Mycobrowser_v4	CDS	166017	167039	.	+	0	Mb0144	Mb0144		possible oxidoreductase	Mb0144, -, len: 340 aa. Equivalent to Rv0139, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). Putative oxidoreductase (EC 1.-.-.-), similar to others e.g. O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa),FASTA scores: opt: 507, E (): 5.8e-27, (31.1% identity in 328 aa overlap); TRE_STRGR|P29782 dtdp-glucose 4,6-dehydratase (328 aa), FASTA scores: opt: 254, E(): 2.6e-10, (29.0% identity in 307 aa overlap).	Q7U2R9,A0A1R3XUG7	No	intermediary metabolism and respiration			A0A1R3XUG7				IPR001509,IPR016040	Q7U2R9					Rv0139		Rv0139			
NC_002945.3	Mycobrowser_v4	CDS	167100	167480	.	+	0	Mb0145	Mb0145		conserved protein	Mb0145, -, len: 126 aa. Equivalent to Rv0140, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Conserved hypothetical protein, similar to others e.g. P74567|D90916_48 HYPOTHETICAL 20.8 KDP ROTEIN from Synechocystis sp. (180 aa), FASTA scores: opt: 229, E(): 4.7e-10, (36.1% identity in 108 aa overlap). Also similar to Rv1056 and Rv1670 from Mycobacterium tuberculosis.	Q7U2R8,A0A1R3XUF6	No	conserved hypotheticals			A0A1R3XUF6				IPR007361	Q7U2R8					Rv0140		Rv0140			
NC_002945.3	Mycobrowser_v4	CDS	168894	170372	.	-	0	Mb0148c	Mb0148c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0148c, -, len: 492 aa. Equivalent to Rv0143c,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Probable conserved transmembrane protein, CIC family possibly involved in transport of chloride, similar to others and hypothetical proteins e.g. O28857 PUTATIVE CHLORIDE CHANNEL from Archaeoglobus fulgidus (589 aa), FASTA scores: opt: 966,E(): 0, (37.7% identity in 453 aa overlap); YADQ_ECOLI|P37019 hypothetical 46.0 kd protein (436 aa),FASTA scores: opt: 452, E(): 2.4e-20, (28.0% identity in 460 aa overlap).	Q7U2R5,A0A1R3XWM0	No	cell wall and cell processes			A0A1R3XWM0				IPR001807,IPR014743	Q7U2R5					Rv0143c		Rv0143c			
NC_002945.3	Mycobrowser_v4	CDS	249234	250319	.	+	0	Mb0215	Mb0215		HYPOTHETICAL PROTEIN	Mb0215, -, len: 361 aa. Equivalent to Rv0209, len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 361 aa overlap). Hypothetical unknown protein.	Q7U2K3,A0A1R3XUQ0	No	conserved hypotheticals			A0A1R3XUQ0					Q7U2K3					Rv0209		Rv0209			
NC_002945.3	Mycobrowser_v4	CDS	170474	171316	.	+	0	Mb0149	Mb0149		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)	Mb0149, -, len: 280 aa. Equivalent to Rv0144, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable transcriptional regulator, possibly tetR family. Has region similar to others e.g. Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli strains K12 and O157:H7 (196 aa), FASTA scores: opt: 214, E(): 1.1e-06, (26.0% identity in 196 aa overlap). Contains probable helix-turn helix motif from aa 109-130 (Score 1463, +4.17 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7U2R4,A0A1R3XVL1	No	regulatory proteins			A0A1R3XVL1				IPR001647,IPR009057,IPR011075,IPR015893	Q7U2R4					Rv0144		Rv0144			
NC_002945.3	Mycobrowser_v4	CDS	173428	174948	.	+	0	Mb0152	Mb0152		probable aldehyde dehydrogenase (nad+) dependent	Mb0152, -, len: 506 aa. Equivalent to Rv0147, len: 506 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 506 aa overlap). Probable aldehyde dehydrogenase (NAD+) dependant (EC 1.2.1.-), similar to others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric NADP-preferring) (452 aa), FASTA scores: opt: 1291, E(): 0, (43.9% identity in 453 aa overlap). Also similar to several Mycobacterium tuberculosis aledehyde dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 aldehyde dehydrogenases glutamic acid active site, and PS00070 aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.	Q7U2R1,A0A1R3XUG0	No	intermediary metabolism and respiration			A0A1R3XUG0				IPR012394,IPR015590,IPR016160,IPR016161,IPR016162,IPR016163	Q7U2R1					Rv0147		Rv0147			
NC_002945.3	Mycobrowser_v4	CDS	175023	175883	.	+	0	Mb0153	Mb0153		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb0153, -, len: 286 aa. Equivalent to Rv0148, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable short-chain dehydrogenase (EC 1.-.-.-), similar to others, in particular Estradiol 17 beta-dehydrogenases (EC 1.1.1.62),e.g. DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 (735 aa), FASTA scores: opt: 952, E(): 0, (52.5% identity in 276 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7U2R0,A0A1R3XUF8	No	intermediary metabolism and respiration			A0A1R3XUF8				IPR002198,IPR002347,IPR016040,IPR020904	Q7U2R0					Rv0148		Rv0148			
NC_002945.3	Mycobrowser_v4	CDS	328030	328650	.	-	0	Mb0279c	Mb0279c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0279c, -, len: 206 aa. Equivalent to Rv0273c,len: 206 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 206 aa overlap). Possible transcriptional regulator, showing some similarity to hypothetical regulators from Mycobacterium tuberculosis e.g. P96222|Rv3855|MTCY01A6.13c (216 aa); O08377|Rv1534|MTCY07A7A.03 (225 aa), FASTA scores: opt: 123, E(): 3.2e-06, (28.5% identity in 172 aa overlap).	Q7U2E3,A0A1R3XV07	No	regulatory proteins			A0A1R3XV07				IPR001647,IPR009057,IPR011075,IPR015893	Q7U2E3					Rv0273c		Rv0273c			
NC_002945.3	Mycobrowser_v4	CDS	175890	176858	.	+	0	Mb0154	Mb0154		possible quinone oxidoreductase (nadph:quinone oxidoreductase) (zeta-crystallin)	Mb0154, -, len: 322 aa. Equivalent to Rv0149, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 322 aa overlap). Putative quinone oxidoreductase (EC 1.6.5.-), similar to others oxidoreductases e.g. Q08257 quinone oxidoreductase (EC 1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18,(28.4% identity in 328 aa overlap); SCHCOADH_4 from Streptomyces coelicolor. Also similar to many proteins from Mycobacterium tuberculosis. Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. BELONG TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY.	Q7U2Q9,A0A1R3XUH2	No	intermediary metabolism and respiration			A0A1R3XUH2				IPR002085,IPR002364,IPR011032,IPR013149,IPR013154,IPR016040	Q7U2Q9					Rv0149		Rv0149			
NC_002945.3	Mycobrowser_v4	CDS	176855	177142	.	-	0	Mb0155c	Mb0155c		CONSERVED HYPOTHETICAL PROTEIN	Mb0155c, -, len: 95 aa. Equivalent to Rv0150c, len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 95 aa overlap). Conserved hypothetical protein, showing some similarity with C-terminus of O53949|Rv1800|MTV049.22 PPE-FAMILY PROTEIN from Mycobacterium tuberculosis (655 aa), FASTA score: (36.5% identity in 104 aa overlap).	Q7U2Q8,A0A1R3XUG3	No	conserved hypotheticals			A0A1R3XUG3					Q7U2Q8					Rv0150c		Rv0150c			
NC_002945.3	Mycobrowser_v4	CDS	186685	186813	.	-	0	Mb0162A	Mb0162A		Conserved protein	Mb0162A, len: 42 aa. Equivalent to Rv0157A len: 42 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 42 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein,showing similarity to C-terminal part (aa 186-220) of O53976|Rv1975|MTV051.13 conserved hypothetical protein from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 173, E(): 3e-06, (62.5% identity in 40 aa overlap).	X2BE85,A0A1R3XUI2	No	conserved hypotheticals			A0A1R3XUI2					X2BE85					Rv0157A		Rv0157A			
NC_002945.3	Mycobrowser_v4	CDS	186975	187619	.	+	0	Mb0163	Mb0163		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)	Mb0163, -, len: 214 aa. Equivalent to Rv0158, len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable transcriptional regulator, possibly TetR family, showing weak similarity to various transcriptional activators and repressors e.g. P32398|YIXD_BACSU|YHGD HYPOTHETICAL TRANSCRIPTIONAL REGULATORY PROTEIN from Bacillus subtilis (191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0% identity in 191 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1296, +3.60 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7U2Q0,A0A1R3XUH6	No	regulatory proteins			A0A1R3XUH6				IPR001647,IPR009057,IPR011075,IPR013571,IPR015893	Q7U2Q0					Rv0158		Rv0158			
NC_002945.3	Mycobrowser_v4	CDS	190797	192146	.	+	0	Mb0166	Mb0166		possible oxidoreductase	Mb0166, -, len: 449 aa. Equivalent to Rv0161, len 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 actin interacting protein 2 (530 aa),FASTA scores: opt: 356, E (): 0, (33.3% identity in 357 aa overlap); DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome) (587 aa), FASTA scores: opt: 311, E(): 2.5e-20, (27.9% identity in 366 aa overlap). Also similar to other Mycobacteria proteins e.g. MTCY339.30c from M. tuberculosis FASTA score: (29.4% identity in 357 aa overlap); MLCL622.30c from Mycobacterium tuberculosis (449 aa).	Q7U2P7,A0A1R3XUI9	No	intermediary metabolism and respiration			A0A1R3XUI9				IPR004113,IPR006094,IPR016164,IPR016166,IPR016167,IPR016169,IPR016171	Q7U2P7					Rv0161		Rv0161			
NC_002945.3	Mycobrowser_v4	CDS	193307	193762	.	+	0	Mb0168	Mb0168		conserved protein	Mb0168, -, len: 151 aa. Equivalent to Rv0163, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, similar to others e.g. Q44017 HYPOTHETICAL 16.6 KDA PROTEIN IN GBD 5'REGION (ORF6)from Alcaligenes eutrophus (145 aa), FASTA scores: opt: 155,E(): 0.0002, (26.6% identity in 139 aa overlap). Also weak similary with MTV008.31c|Rv2475c|B70867 from Mycobacterium tuberculosis (138 aa).	Q7U2P5,A0A1R3XVM8	No	conserved hypotheticals			A0A1R3XVM8				IPR006683	Q7U2P5					Rv0163		Rv0163			
NC_002945.3	Mycobrowser_v4	CDS	207006	207647	.	+	0	Mb0181	Mb0181		PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN	Mb0181, -, len: 213 aa. Equivalent to Rv0175, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Probable conserved Mce-associated membrane protein, equivalent, but longer in N-terminus, to CAC32127.1|AL583926 possible membrane protein from Mycobacterium leprae (182 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Contains two 12 residue direct repeats at N-terminus.	Q7U2N3,A0A1R3XV45	No	cell wall and cell processes			A0A1R3XV45					Q7U2N3					Rv0175		Rv0175			
NC_002945.3	Mycobrowser_v4	CDS	212469	213203	.	-	0	Mb0187c	Mb0187c		CONSERVED HYPOTHETICAL PROTEIN	Mb0187c, -, len: 244 aa. Equivalent to Rv0181c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd protein from Escherichia coli (231 aa), FASTA scores: opt: 479, E(): 1.2e-29, (37.3% identity in 233 aa overlap); P73623|SLL1773 HYPOTHETICAL 25.7 KD PROTEIN from Synechocystis sp. strain PCC 6803 (232 aa), FASTA score: (39.1% identity in 233 aa overlap).	X2BEB5,P65725,P65725	No	conserved hypotheticals			P65725					X2BEB5,P65725					Rv0181c		Rv0181c			
NC_002945.3	Mycobrowser_v4	CDS	269898	271163	.	-	0	Mb0232c	Mb0232c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0232c, -, len: 421 aa. Equivalent to Rv0227c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 421 aa overlap). Possible conserved membrane protein, equivalent to AL022486|MLCB1883_4 from Mycobacterium leprae (448 aa), FASTA scores: opt: 2148,E(): 0, (76.6% identity in 423 aa overlap).	Q7U2I7,A0A1R3XUP4	No	cell wall and cell processes			A0A1R3XUP4				IPR021424	Q7U2I7					Rv0227c		Rv0227c			
NC_002945.3	Mycobrowser_v4	CDS	219678	220109	.	+	0	Mb0194	Mb0194		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0194, -, len: 143 aa. Equivalent to Rv0188, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Probable conserved transmembrane protein, similar to T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable membrane protein from Streptomyces coelicolor (147 aa),FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity in 141 aa overlap); N-terminus of P80185|MTRC_METTH TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT C (EC 2.1.1.86) from Methanobacterium thermoautotrophicum strain Marburg/DSM 2133 (266 aa), FASTA scores: opt: 125, E(): 0.033, (31.6% identity in 98 aa overlap). Also similar to Rv3635 from Mycobacterium tuberculosis.	Q7U2M1,A0A1R3XUK2	No	cell wall and cell processes			A0A1R3XUK2				IPR005530	Q7U2M1					Rv0188		Rv0188			
NC_002945.3	Mycobrowser_v4	CDS	207644	208612	.	+	0	Mb0182	Mb0182		PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE PROTEIN	Mb0182, -, len: 322 aa. Equivalent to Rv0176, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 322 aa overlap). Probable conserved Mce-associated transmembrane protein. Contains short region of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 kDa antigen) from Mycobacterium leprae (249 aa) (outside the proline-rich region), FASTA scores: opt: 165, E(): 2.9e-05, (40.0% identity in 65 aa overlap). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv3493c, etc.	Q7U2N2,A0A1R3XUI8	No	cell wall and cell processes			A0A1R3XUI8				IPR010432	Q7U2N2					Rv0176		Rv0176			
NC_002945.3	Mycobrowser_v4	CDS	242172	243455	.	-	0	Mb0210c	Mb0210c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0210c, -, len: 427 aa. Equivalent to Rv0204c,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 412 aa overlap). Probable conserved transmembrane protein, equivalent, but has C-terminal extension, to Z95398|MLCL622.17c from Mycobacterium leprae (367 aa), FASTA scores: opt: 2002, E(): 0, (82.4% identity in 374 aa overlap). Some similarity to Rv0585c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 a versus 412 aa).	Q7U2K7,A0A1R3XV83	No	cell wall and cell processes			A0A1R3XV83				IPR022791	Q7U2K7					Rv0204c		Rv0204c			
NC_002945.3	Mycobrowser_v4	CDS	208609	209163	.	+	0	Mb0183	Mb0183		PROBABLE CONSERVED MCE ASSOCIATED PROTEIN	Mb0183, -, len: 184 aa. Equivalent to Rv0177, len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Probable conserved Mce-associated protein, equivalent to CAC32129.1|AL583926 conserved membrane protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv1973, Rv3493c,etc.	Q7U2N1,A0A1R3XUJ6	No	conserved hypotheticals			A0A1R3XUJ6					Q7U2N1					Rv0177		Rv0177			
NC_002945.3	Mycobrowser_v4	CDS	209130	209864	.	+	0	Mb0184	Mb0184		PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN	Mb0184, -, len: 244 aa. Equivalent to Rv0178, len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable conserved Mce-associated membrane protein, highly similar in C-terminus to CAC32130.1|AL583926 putative secreted protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10 aa overlap with the upstream ORF.	Q7U2N0,A0A1R3XUJ5	No	cell wall and cell processes			A0A1R3XUJ5					Q7U2N0					Rv0178		Rv0178			
NC_002945.3	Mycobrowser_v4	CDS	520092	520586	.	+	0	Mb0439	Mb0439		PUTATIVE TUBERCULIN RELATED PEPTIDE	Mb0439, -, len: 164 aa. Equivalent to Rv0431, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 164 aa overlap). Putative tuberculin related peptide; almost identical to D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis (172 aa), FASTA score: (99.4% identity in 163 aa overlap). Highly similar to to CAC30881.1|AL583923 tuberculin related peptide (AT103) from Mycobacterium leprae (167 aa). Some similarity to G550415|HRPC (282 aa), FASTA scores: opt: 120, E(): 0.36, (33.3% identity in 111 aa overlap). Potential transmembrane domain at aa 19-37.	Q7U204,A0A1R3XWD6	No	cell wall and cell processes			A0A1R3XWD6				IPR027381	Q7U204					Rv0431		Rv0431			
NC_002945.3	Mycobrowser_v4	CDS	224917	226764	.	-	0	Mb0199c	Mb0199c		HYPOTHETICAL PROTEIN	Mb0199c, -, len: 615 aa. Equivalent to Rv0193c,len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 615 aa overlap). Hypothetical unknown protein.	Q7U2L7,A0A1R3XUT0	No	conserved hypotheticals			A0A1R3XUT0					Q7U2L7					Rv0193c		Rv0193c			
NC_002945.3	Mycobrowser_v4	CDS	214280	215119	.	+	0	Mb0189	Mb0189		POSSIBLE LYSOPHOSPHOLIPASE	Mb0189, -, len: 279 aa. Equivalent to Rv0183, len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Possible lysophospholipase (EC 3.1.-.-), similar to several (especially eukaryotic enzymes, weaker with Escherichia coli), e.g. U67963|HSU67963_1 Human lysophospholipase homolog from Homo sapiens (313 aa), FASTA scores: opt: 569, E(): 2.6e-29, (37.1% identity in 259 aa overlap); P07000|PLDB_ECOLI LYSOPHOSPHOLIPASE L2 from Escherichia coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start changed based on similarity to AE001997_8 from Deinococcus radiodurans (282 aa), FASTA scores: opt: 510, E(): 1.4e-25, (34.8% identity in 282 aa overlap). Also shows some similarity to epoxide hydrolases from Mycobacterium tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in 114 aa overlap); and O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa). Note that the putative product of this CDS corresponds to spot 3_329 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below).	Q7U2M6,A0A1R3XVP9	No	intermediary metabolism and respiration			A0A1R3XVP9				IPR000073	Q7U2M6					Rv0183		Rv0183			
NC_002945.3	Mycobrowser_v4	CDS	215161	215910	.	+	0	Mb0190	Mb0190		CONSERVED HYPOTHETICAL PROTEIN	Mb0190, -, len: 249 aa. Equivalent to Rv0184, len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Conserved hypothetical protein, equivalent to CAC32136.1|AL583926 conserved hypothetical protein from Mycobacterium lepra (249 aa); and C-terminus highly similar to CAB08793.1|Z95398 conserved hypothetical protein from Mycobacterium leprae (145 aa), FASTA scores: E(): 0, (75.2 identity in 145 aa overlap). Also similar to 049841|SCE9_39|T36358 hypothetical protein from Streptomyces coelicolor (418 aa), FASTA scores: opt: 231,E(): 8.1e-08, (30.4% identity in 270 aa overlap).	Q7U2M5,A0A1R3XUS0	No	conserved hypotheticals			A0A1R3XUS0				IPR024498	Q7U2M5					Rv0184		Rv0184			
NC_002945.3	Mycobrowser_v4	CDS	215907	216416	.	+	0	Mb0191	Mb0191		CONSERVED HYPOTHETICAL PROTEIN	Mb0191, -, len: 169 aa. Equivalent to Rv0185, len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Conserved hypothetical protein, equivalent to CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in 165 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.	Q7U2M4,A0A1R3XV55	No	conserved hypotheticals			A0A1R3XV55				IPR027595	Q7U2M4					Rv0185		Rv0185			
NC_002945.3	Mycobrowser_v4	CDS	218897	219559	.	+	0	Mb0193	Mb0193		PROBABLE O-METHYLTRANSFERASE	Mb0193, -, len: 220 aa. Equivalent to Rv0187, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable O-methyltransferase (EC 2.1.1.-), similar to many e.g. AB93458.1|AL357591 putative O-methyltransferase from Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719 O-methyltransferase from Streptomyces mycarofaciens (221 aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity in 192 aa overlap). Also similar to Rv1703c, Rv1220c from Mycobacterium tuberculosis.	Q7U2M2,A0A1R3XUK3	No	intermediary metabolism and respiration			A0A1R3XUK3				IPR002935	Q7U2M2					Rv0187		Rv0187			
NC_002945.3	Mycobrowser_v4	CDS	222481	223722	.	+	0	Mb0197	Mb0197		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0197, -, len: 413 aa. Equivalent to Rv0191, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug,similar to several hypothetical proteins e.g. YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from Escherichia coli (396 aa), FASTA scores: opt: 475, E(): 4.2e-33, (29.7% identity in 381 aa overlap); and to several chloramphenicol resistance proteins e.g. CMLR_STRLI|P31141 chloramphenicol resistance protein from stremtomyces lividans (392 aa), FASTA scores: opt: 394,E(): 6.7e-12, (28.2% identity in 383 aa overlap). Also similar to SVU09991_1 from Mycobacterium tuberculosis.	Q7U2L9,A0A1R3XWR9	No	cell wall and cell processes			A0A1R3XWR9				IPR011701,IPR016196,IPR020846	Q7U2L9					Rv0191		Rv0191			
NC_002945.3	Mycobrowser_v4	CDS	223799	224857	.	+	0	Mb0198	Mb0198		conserved secreted protein	Mb0198, -, len: 352 aa. Equivalent to Rv0192 and Rv0192A, len: 366 aa and 100 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 318 aa overlap and 91.1% identity in 56 aa overlap). Conserved hypothetical protein. Has Gly- Arg-rich region followed by highly Pro-rich repetitive region near N-terminus. Similar in C-terminus to other hypothetical proteins e.g. Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09 hypothetical 47.9 kd protein from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 330, E(): 3.2e-13, (35.1% identity in 271 aa overlap). Also similar to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium tuberculosis. Probable N-terminal part of Rv0192, which is member of family P5.17 with Rv0116c, Rv1433, Rv2518c,Rv0483. These are all predicted to be exported/membrane proteins. Rv0192A has typical N-terminal signal peptide which is functional and was identified by PhoA fusion screens: O52054 PGB14T-O1 PRECURSOR (FRAGMENT 45 AA) (see citation below). Since Rv0192 misses a signal peptide this suggests that there is a frameshift in the region of the overlap with Rv0192 but none found on reinspection of sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis, a single base insertion (*-g) leads to a single product.	Q7U2L8,A0A1R3XVR0	No	conserved hypotheticals			A0A1R3XVR0				IPR005490	Q7U2L8					Rv0192		Rv0192			
NC_002945.3	Mycobrowser_v4	CDS	227071	230655	.	+	0	Mb0200	Mb0200		probable transmembrane multidrug efflux pump	Mb0200, -, len: 1194 aa. Equivalent to Rv0194, len: 1194 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 1194 aa overlap). Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), highly similar to many e.g. U62129|STU62129_2|T30293 ABC transport protein homolog from Salmonella typhi (1218 aa), FASTA scores: opt: 1116, E(): 0, (36.3% identity in 1209 aa overlap); CAB66302.1|AL136519 ABC transporter protein ATP-binding component from Streptomyces coelicolor (1243 aa); I84547 mdl protein from Escherichia coli (1143 aa); etc. Also similar to MTCY50_9 and MTCY50_10 from Mycobacterium tuberculosis, FASTA score: (33.8% identity in 574 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop) and one PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Alternative start possible at 1823 but no RBS.	Q7U2L6,A0A1R3XV67	No	cell wall and cell processes			A0A1R3XV67				IPR001140,IPR003439,IPR003593,IPR011527,IPR017871,IPR027417	Q7U2L6					Rv0194		Rv0194			
NC_002945.3	Mycobrowser_v4	CDS	231093	231728	.	+	0	Mb0201	Mb0201		possible two component transcriptional regulatory protein (probably luxr-family)	Mb0201, -, len: 211 aa. Equivalent to Rv0195, len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Putative two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 SD).	Q7U2L5,A0A1R3XUL6	No	regulatory proteins			A0A1R3XUL6				IPR000792,IPR011991,IPR016032	Q7U2L5					Rv0195		Rv0195			
NC_002945.3	Mycobrowser_v4	CDS	231841	232425	.	+	0	Mb0202	Mb0202		possible transcriptional regulatory protein	Mb0202, -, len: 194 aa. Equivalent to Rv0196, len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 194 aa overlap). Putative transcriptional regulatory protein, similar to two Bacillus subtilis regulators: P42105|YXAF_BACSU HYPOTHETICAL 21.0 KD PROTEIN (191 aa), FASTA scores: opt: 323, E(): 2.1e-15, (30.9% identity in 181 aa overlap); and Z99105|BSUB0002_9 negative regulator of the lincomycin operon (188 aa), FASTA scores: opt: 255, E(): 1e-10, (25.9 identity in 185 aa overlap).	Q7U2L4,A0A1R3XUL5	No	regulatory proteins			A0A1R3XUL5				IPR001647,IPR009057,IPR011075,IPR015893	Q7U2L4					Rv0196		Rv0196			
NC_002945.3	Mycobrowser_v4	CDS	584852	585841	.	-	0	Mb0504c	Mb0504c		conserved protein	Mb0504c, -, len: 329 aa. Equivalent to Rv0493c,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 329 aa overlap). Conserved hypothetical protein, showing some similarity to U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa), FASTA scores: opt: 166, E(): 0.00077, (35.9% identity in 131 aa overlap).	Q7U1W4,A0A1R3XVG9	No	conserved hypotheticals			A0A1R3XVG9					Q7U1W4					Rv0493c		Rv0493c			
NC_002945.3	Mycobrowser_v4	CDS	232425	234671	.	+	0	Mb0203	Mb0203		POSSIBLE OXIDOREDUCTASE	Mb0203, -, len: 748 aa. Equivalent to Rv0197, len: 762 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 748 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to others e.g. 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin oxidoreductase from Pseudomonas aeruginosa strain PAO1 (769 aa); 5441785|CAB46809.1|AL096811|T36812 probable dehydrogenase from Streptomyces coelicolor (747 aa), FASTA scores: opt: 617, E(): 9.8e-30, (29.9% identity in 762 aa overlap); BAB04334.1|AP001509 assimilatory nitrate reductase (catalytic subunit) from Bacillus halodurans (743 aa); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (t-g) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa).	Q7U2L3,A0A1R3XUL4	No	intermediary metabolism and respiration			A0A1R3XUL4				IPR006656,IPR006657,IPR006963,IPR009010	Q7U2L3					Rv0197		Rv0197			
NC_002945.3	Mycobrowser_v4	CDS	236746	237405	.	+	0	Mb0205	Mb0205		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0205, -, len: 219 aa. Equivalent to Rv0199, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Probable conserved membrane protein, equivalent to Z95398|MLCL622.13 from Mycobacterium leprae (224 aa), FASTA scores: opt: 920,E(): 0, (67.7% identity in 220 aa overlap). Also some similarity to Mce-associated membrane proteins from Mycobacterium tuberculosis e.g. Rv0178, Rv0175, etc.	Q7U2L1,A0A1R3XUN7	No	cell wall and cell processes			A0A1R3XUN7					Q7U2L1					Rv0199		Rv0199			
NC_002945.3	Mycobrowser_v4	CDS	237402	238091	.	+	0	Mb0206	Mb0206		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0206, -, len: 229 aa. Equivalent to Rv0200, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Possible conserved transmembrane protein, equivalent to Z95398|MLCL622.14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1147, E(): 0, (74.7% identity in 229 aa overlap). Also some similarity to Rv1973 from Mycobacterium tuberculosis (160 aa); and Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA scores: opt: 134, E(): 0.063, (25.8% identity in 159 aa overlap).	Q7U2L0,A0A1R3XUM6	No	cell wall and cell processes			A0A1R3XUM6					Q7U2L0					Rv0200		Rv0200			
NC_002945.3	Mycobrowser_v4	CDS	243580	244683	.	+	0	Mb0211	Mb0211		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0211, -, len: 367 aa. Equivalent to Rv0205, len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 367 aa overlap). Possible conserved transmembrane protein, similar to hypothetical proteins from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces coelicolor (402 aa), FASTA scores: opt: 436, E(): 1.7e-21,(27.2% identity in 349 aa overlap); Z99117|BSUB0014_221 from Bacillus subtilis (353 aa), FASTA scores: opt: 394,E(): 8.6e-19, (28.7% identity in 324 aa overlap).	Q7U2K6,A0A1R3XUM8	No	cell wall and cell processes			A0A1R3XUM8				IPR002549	Q7U2K6					Rv0205		Rv0205			
NC_002945.3	Mycobrowser_v4	CDS	247580	248308	.	-	0	Mb0213c	Mb0213c		CONSERVED HYPOTHETICAL PROTEIN	Mb0213c, -, len: 242 aa. Equivalent to Rv0207c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap).	Q7U2K4,A0A1R3XUM4	No	conserved hypotheticals			A0A1R3XUM4				IPR021139	Q7U2K4					Rv0207c		Rv0207c			
NC_002945.3	Mycobrowser_v4	CDS	248311	249102	.	-	0	Mb0214c	Mb0214c		HYPOTHETICAL METHLYTRANSFERASE (METHYLASE)	Mb0214c, -, len: 263 aa. Equivalent to Rv0208c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 263 aa overlap). Hypothetical methyltransferase (EC 2.1.1.-), equivalent to Z95398|MLCL622_20 from Mycobacterium leprae (279 aa),FASTA score: (64.2% identity in 246 aa overlaps). Also similar to others e.g. 10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c HYPOTHETICAL METHLYTRANSFERASE from Streptomyces coelicolor (271 aa). Could start at aa 7.	X2BE98,P67499,P67499	No	intermediary metabolism and respiration			P67499					X2BE98,P67499					Rv0208c		Rv0208c			
NC_002945.3	Mycobrowser_v4	CDS	623271	623432	.	-	0	Mb0543A	Mb0543A		Conserved protein	Mb0543A, len: 53 aa. Equivalent to Rv0530A len: 53 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 53 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BFB5,A0A1R3XVM0	No	conserved hypotheticals			A0A1R3XVM0					X2BFB5					Rv0530A		Rv0530A			
NC_002945.3	Mycobrowser_v4	CDS	384632	385516	.	+	0	Mb0323	Mb0323		POSSIBLE BETA-1,3-GLUCANASE PRECURSOR	Mb0323, -, len: 294 aa. Equivalent to Rv0315, len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 294 aa overlap). Possible beta-1,3-glucanase precursor (EC 3.2.1.-) (has hydrophobic stretch in its N-terminal part), similar to others e.g. Q51333|AAC44371.1 BETA-1,3-GLUCANASE II A from Oerskovia xanthineolytica (306 aa), FASTA scores: opt: 76, E(): 3e-14, (34.1% identity in 302 aa overlap); and AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia xanthineolytica (435 aa). Contains glycosyl hydrolases family 16 active site signature (PS01034).	Q7U2A2,A0A1R3XUY5	No	intermediary metabolism and respiration			A0A1R3XUY5				IPR000757,IPR006311,IPR008985,IPR013320	Q7U2A2					Rv0315		Rv0315			
NC_002945.3	Mycobrowser_v4	CDS	254833	256146	.	-	0	Mb0219c	Mb0219c		POSSIBLE METHYLTRANSFERASE (METHYLASE)	Mb0219c, -, len: 437 aa. Equivalent to Rv0213c,len: 437 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 437 aa overlap). Possible methyltransferase (EC 2.1.1.-), weakly similar to others methyltransferases e.g. AF127374_30|LINA from Streptomyces lavendulae (611 aa), FASTA scores: opt: 400, E(): 8.1e-19,(27.3% identity in 388 aa overlap); Q50258 fortimicin kl1 methyltransferase (553 aa), FASTA scores: opt: 267, E(): 1.2e-13, (29.3% identity in 351 aa overlap).	Q7U2K0,A0A1R3XUU6	No	intermediary metabolism and respiration			A0A1R3XUU6				IPR006158,IPR006638,IPR007197,IPR023404,IPR023970	Q7U2K0					Rv0213c		Rv0213c			
NC_002945.3	Mycobrowser_v4	CDS	259138	260151	.	+	0	Mb0222	Mb0222		double hotdog hydratase	Mb0222, -, len: 337 aa. Equivalent to Rv0216, len: 337 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 337 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622_22 from Mycobacterium leprae (339 aa), FASTA scores: E(): 0, (73.7 identity in 338 aa overlap).	Q7U2J7,A0A1R3XUN4	No	intermediary metabolism and respiration			A0A1R3XUN4				IPR016790	Q7U2J7					Rv0216		Rv0216			
NC_002945.3	Mycobrowser_v4	CDS	261149	262477	.	+	0	Mb0224	Mb0224		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0224, -, len: 442 aa. Equivalent to Rv0218, len: 442 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 442 aa overlap). Probable conserved transmembrane protein, some similarity with sulfite oxidases (EC 1.8.3.1) e.g. SUOX_HUMAN|P51687 sulfite oxidase precursor (488 aa), FASTA scores: opt: 153, E(): 0.0087, (28.6% identity in 161 aa overlap); and with some nitrate reductases (EC 1.6.6.3) e.g. NIA_FUSOX|P39863 nitrate reductase (NADPH) (905 aa), FASTA scores: opt: 143, E(): 0.06, (29.3% identity in 92 aa overlap). Also similar to BSUB0017_86 from Mycobacterium tuberculosis.	Q7U2J5,A0A1R3XUN5	No	cell wall and cell processes			A0A1R3XUN5				IPR000572	Q7U2J5					Rv0218		Rv0218			
NC_002945.3	Mycobrowser_v4	CDS	264292	265065	.	+	0	Mb0227	Mb0227		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb0227, -, len: 257 aa. Equivalent to 5' end of Rv0221, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 234 aa overlap). Conserved hypothetical protein, similar to others proteins from Mycobacterium tuberculosis e.g. Q50680|Rv2285|MT2343|MTCY339.25c hypothetical 47.7 kDa protein (445 aa), FASTA scores: opt: 455, E(): 8.1e-23,(26.7% identity in 461 aa overlap); Rv3740c, Rv3734c, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein,echA1 (Rv0222).	Q7U2J2,A0A1R3XWV2	No				A0A1R3XWV2				IPR004255	Q7U2J2										
NC_002945.3	Mycobrowser_v4	CDS	264931	266088	.	-	0	Mb0228c	Mb0228c		PROBABLE ALDEHYDE DEHYDROGENASE	Mb0228c, -, len: 385 aa. Equivalent to Rv0223c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(95.3% identity in 364 aa overlap). Probable aldehyde dehydrogenase (EC 1.2.1.-), similar to others e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde dehydrogenase from Deinococcus radiodurans strain R1 (495 aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent from Gluconobacter oxydans (498 aa), FASTA scores: opt: 1157, E (): 0, (42.1% identity in 482 aa overlap); etc. Also similar to Rv0768, Rv2858c, etc from Mycobacterium tuberculosis. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site; and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to a shorter product,with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 487 aa).	Q7U2J1,A0A1R3XVT5	No	intermediary metabolism and respiration			A0A1R3XVT5				IPR015590,IPR016160,IPR016161,IPR016162,IPR016163	Q7U2J1					Rv0223c		Rv0223c			
NC_002945.3	Mycobrowser_v4	CDS	266187	266951	.	-	0	Mb0229c	Mb0229c		POSSIBLE METHYLTRANSFERASE (METHYLASE)	Mb0229c, -, len: 254 aa. Equivalent to Rv0224c,len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 254 aa overlap). Possible methyltransferase (EC 2.1.1.-), showing weak similarity with other methyltransferases e.g. P74388 STEROL-C-METHYLTRANSFERASE (318 aa), FASTA scores: opt: 190, E(): 3.6e-05, (33.3% identity in 114 aa overlap). Equivalent to AL022486|MLCB1883_1 from Mycobacterium leprae (269 aa), FASTA scores: opt: 1456, E(): 0, (82.9% identity in 252 aa overlap). Also some similarity with MTCY21B4.22c from Mycobacterium tuberculosis FASTA score: (30.1% identity in 136 aa overlap).	X2BEA5,Q7U2J0,Q7U2J0	No	intermediary metabolism and respiration			Q7U2J0					X2BEA5,Q7U2J0					Rv0224c		Rv0224c			
NC_002945.3	Mycobrowser_v4	CDS	266987	268141	.	+	0	Mb0230	Mb0230		POSSIBLE CONSERVED PROTEIN	Mb0230, -, len: 384 aa. Equivalent to Rv0225, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 384 aa overlap). Possible conserved protein involved in LPS biosynthesis, similar to O26275 LPS BIOSYNTHESIS RFBU RELATED PROTEIN (382 aa), FASTA scores: opt: 426, E(): 1.2e-20, (28.2% identity in 394 aa overlap). Some similarity with Rv3032 from Mycobacterium tuberculosis FASTA score: (31.6% identity in 228 aa overlap).	Q7U2I9,A0A1R3XVA2	No	cell wall and cell processes			A0A1R3XVA2				IPR001296	Q7U2I9					Rv0225		Rv0225			
NC_002945.3	Mycobrowser_v4	CDS	321089	321598	.	-	0	Mb0274c	Mb0274c		HYPOTHETICAL PROTEIN	Mb0274c, -, len: 169 aa. Equivalent to Rv0268c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Hypothetical unknown protein.	Q7U2E8,A0A1R3XUT3	No	conserved hypotheticals			A0A1R3XUT3				IPR006442	Q7U2E8					Rv0268c		Rv0268c			
NC_002945.3	Mycobrowser_v4	CDS	268158	269888	.	-	0	Mb0231c	Mb0231c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0231c, -, len: 576 aa. Equivalent to Rv0226c,len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 576 aa overlap). Probable conserved transmembrane protein, equivalent, except in N-terminal part, to AC32114.1|AL583926 conserved membrane protein from Mycobacterium leprae (600 aa), FASTA scores: opt: 2086, E(): 0, (70.3% identity in 579 aa overlap). Also similar to AL021411|SC7H1_20 from Streptomyces coelicolor (483 aa), FASTA scores: opt: 180, E(): 0.00028, (26.5 identity in 388 aa overlap).	Q7U2I8,A0A1R3XUP9	No	cell wall and cell processes			A0A1R3XUP9					Q7U2I8					Rv0226c		Rv0226c			
NC_002945.3	Mycobrowser_v4	CDS	286752	287366	.	+	0	Mb0244	Mb0244		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb0244, -, len: 204 aa. Equivalent to Rv0238, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible transcriptional regulatory protein, TetR family,equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative tetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266, E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa).	Q7U2H6,A0A1R3XUQ3	No	regulatory proteins			A0A1R3XUQ3				IPR001647,IPR009057,IPR011075,IPR015893	Q7U2H6					Rv0238		Rv0238			
NC_002945.3	Mycobrowser_v4	CDS	271379	272602	.	+	0	Mb0233	Mb0233		PROBABLE INTEGRAL MEMBRANE ACYLTRANSFERASE	Mb0233, -, len: 407 aa. Equivalent to Rv0228, len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Probable integral membrane acyltransferase (EC 2.3.1.-), equivalent to 3063875|CAA18555.1|AL022486|T44870 ACYLTRANSFERASE from Mycobacterium leprae (384 aa), FASTA scores: opt: 2004,E(): 0, (79.3% identity in 381 aa overlap). Also similar to others e.g. Q11064 PROBABLE ACYLTRANSFERASE CY50.28C (383 aa), FASTA scores: opt: 372, E(): 2.6e-16, (35.9% identity in 359 aa overlap); Q00718|MDMB_STRMY ACYLTRANSFERASE. Very similar to Rv0111, Rv1254, etc from Mycobacterium tuberculosis.	Q7U2I6,A0A1R3XUP3	No	intermediary metabolism and respiration			A0A1R3XUP3				IPR002656	Q7U2I6					Rv0228		Rv0228			
NC_002945.3	Mycobrowser_v4	CDS	272630	273310	.	-	0	Mb0234c	Mb0234c		possible conserved membrane protein with pin domain	Mb0234c, -, len: 226 aa. Equivalent to Rv0229c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Possible conserved membrane protein, similar to several proteins from Mycobacterium tuberculosis. Other possible start sites and could be shorter as C-terminal region has some similarity with Rv2757c|D70880 from Mycobacterium tuberculosis (138 aa), FASTA scores: E(): 1e-15, (45.3% identity in 137 aa overlap), and Rv0301, Rv2546, etc. Also some similarity with Q48177 virulence associated protein C (132 aa), FASTA scores: opt: 101, E(): 0.6, (24.3% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.	Q7U2I5,A0A1R3XUP7	No	cell wall and cell processes			A0A1R3XUP7				IPR002716,IPR022907	Q7U2I5					Rv0229c		Rv0229c			
NC_002945.3	Mycobrowser_v4	CDS	380202	381431	.	+	0	Mb0319	Mb0319		unknown protein	Mb0319, -, len: 409 aa. Equivalent to Rv0311, len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Hypothetical unknown protein. Contains PS00881 Protein splicing signature.	Q7U2A6,A0A1R3XW19	No	conserved hypotheticals			A0A1R3XW19					Q7U2A6					Rv0311		Rv0311			
NC_002945.3	Mycobrowser_v4	CDS	276223	276912	.	+	0	Mb0237	Mb0237		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY)	Mb0237, -, len: 229 aa. Equivalent to Rv0232, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Probable transcriptional regulatory protein, tetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149, E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, tetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7U2I2,A0A1R3XWW1	No	regulatory proteins			A0A1R3XWW1				IPR001647,IPR009057,IPR011075,IPR015893,IPR023772	Q7U2I2					Rv0232		Rv0232			
NC_002945.3	Mycobrowser_v4	CDS	279490	280938	.	-	0	Mb0240c	Mb0240c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0240c, -, len: 482 aa. Equivalent to Rv0235c,len: 482 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 482 aa overlap). Possible conserved transmembrane protein, highly similar to AL133278|CAB61913.1|SCM11_2 putative integral membrane protein from Streptomyces coelicolor (470 aa), FASTA scores: opt: 2116, E(): 0, (61.8% identity in 474 aa overlap); and similar to hypothetical proteins from other organisms e.g. Q13392|384D8_7 hypothetical protein (579 aa), FASTA scores: opt: 355, E(): 6.9e-17, (28.5% identity in 569 aa overlap).	Q7U2H9,A0A1R3XVC0	No	cell wall and cell processes			A0A1R3XVC0				IPR009613	Q7U2H9					Rv0235c		Rv0235c			
NC_002945.3	Mycobrowser_v4	CDS	328747	329328	.	+	0	Mb0280	Mb0280		conserved protein	Mb0280, -, len: 193 aa. Equivalent to Rv0274, len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 193 aa overlap). Conserved hypothetical protein, highly similar to AAK25058.1|AE005973 conserved hypothetical protein from Caulobacter crescentus (174 aa). Shows also some similarity to others hypothetical proteins e.g. AJ002571|BSAJ2571_7 from Bacillus subtilis (316 aa), FASTA scores: opt: 138, E(): 0.033, (27.1% identity in 133 aa overlap). Previous hits with Q56415|M85195 FOSFOMYCIN-RESISTANCE PROTEIN from SERRATIA MARCESCENS (141 aa), FASTA scores: opt: 82, E(): 1.1e -08, (29.1% identity in 151 aa overlap). Contains PS00082 Extradiol ring-cleavage dioxygenases signature near C-terminus. TBparse score is 0.914.	Q7U2E2,A0A1R3XVF3	No	conserved hypotheticals			A0A1R3XVF3				IPR000486,IPR004360	Q7U2E2					Rv0274		Rv0274			
NC_002945.3	Mycobrowser_v4	CDS	385565	386179	.	+	0	Mb0324	Mb0324		POSSIBLE MUCONOLACTONE ISOMERASE	Mb0324, -, len: 204 aa. Equivalent to Rv0316, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible muconolactone isomerase (EC 5.3.3.-), showing weak similarity with some muconolactone isomerases e.g. O33947|CTC1_ACILW MUCONOLACTONE DELTA-ISOMERASE 1 (MIASE 1)(96 aa), FASTA scores: opt: 179, E(): 3.9e-05, (32.6% identity in 92 aa overlap).	Q7U2A1,A0A1R3XUZ7	No	intermediary metabolism and respiration			A0A1R3XUZ7				IPR003464,IPR011008,IPR026029	Q7U2A1					Rv0316		Rv0316			
NC_002945.3	Mycobrowser_v4	CDS	294330	294818	.	+	0	Mb0251	Mb0251		possible oxidoreductase	Mb0251, -, len: 162 aa. Equivalent to Rv0245, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to AL022486|MLCB1883_17|T44882 probable oxidoreductase from Mycobacterium leprae (162 aa), FASTA scores: opt: 860,E(): 0, (83.4% identity in 157 aa overlap). Also similar to several hypothetical proteins and various oxidoreductases e.g. AAK24246.1|AE005898 NADH:riboflavin 5'-phosphate oxidoreductase from Caulobacter crescentus (174 aa); Q02058|DIM6_STRCO|CAA45048.1 ACTINORHODIN POLYKETIDE DIMERASE from STREPTOMYCES COELICOLOR (177 aa),FASTA scores: opt: 308, E(): 3. 2e-15, (37.8% identity in 143 aa overlap). Also similar to Z84498|Rv1939|MTCY09F9.25c from Mycobacterium tuberculosis (171 aa), FASTA scores: opt: 517, E(): 3.5e-30, (49.4% identity in 158 aa overlap).	Q7U2G9,A0A1R3XUR9	No	intermediary metabolism and respiration			A0A1R3XUR9				IPR002563,IPR012349	Q7U2G9					Rv0245		Rv0245			
NC_002945.3	Mycobrowser_v4	CDS	295134	296444	.	+	0	Mb0252	Mb0252		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0252, -, len: 436 aa. Equivalent to Rv0246, len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 436 aa overlap). Probable conserved integral membrane protein, similar to Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 712, E(): 0, (33.2% identity in 422 aa overlap).	Q7U2G8,A0A1R3XUR4	No	cell wall and cell processes			A0A1R3XUR4				IPR016196	Q7U2G8					Rv0246		Rv0246			
NC_002945.3	Mycobrowser_v4	CDS	296441	297187	.	-	0	Mb0253c	Mb0253c		PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)	Mb0253c, -, len: 248 aa. Equivalent to Rv0247c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Probable succinate dehydrogenase, iron-sulfur subunit (EC 1.3.99.1), highly similar to CAC44313.1|AL596043 putative succinate dehydrogenase iron-sulfur subunit from Streptomyces coelicolor (259 aa); and similar to iron-sulphur protein subunits of fumarate reductase or succinate dehydrogenases from many bacteria e.g. NP_147618.1|7521083|B72691 fumarate reductase iron-sulfur protein from Aeropyrum pernix (305 aa); NP_069516.1|2649932|AAB90556.1|AE001057 succinate dehydrogenase iron-sulfur subunit B (sdhB) from Archaeoglobus fulgidus (236 aa); etc. Also similar to Q10761|FRDB_MYCTU|7431693|F70762 FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 358, E():1e-16, (31.3% identity in 214 aa overlap). Contains PS00197 2Fe-2S ferredoxins,iron-sulfur binding region signature. NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?).	Q7U2G7,A0A1R3XUR7	No	intermediary metabolism and respiration			A0A1R3XUR7				IPR001041,IPR004489,IPR006058,IPR009051,IPR012675,IPR017896	Q7U2G7					Rv0247c		Rv0247c			
NC_002945.3	Mycobrowser_v4	CDS	329258	329983	.	-	0	Mb0281c	Mb0281c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)	Mb0281c, -, len: 241 aa. Equivalent to Rv0275c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 241 aa overlap). Putative transcriptional regulator, showing some similarity with Rv0825c from Mycobacterium tuberculosis (213 aa), FASTA scores: opt: 230, E(): 2.7e-07, (32.6% identity in 190 aa overlap). Belongs to Mycobacterium tuberculosis regulatory protein family with many TetR orthologues.	Q7U2E1,A0A1R3XUV3	No	regulatory proteins			A0A1R3XUV3				IPR001647,IPR009057,IPR015893	Q7U2E1					Rv0275c		Rv0275c			
NC_002945.3	Mycobrowser_v4	CDS	297188	299128	.	-	0	Mb0254c	Mb0254c		PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)	Mb0254c, -, len: 646 aa. Equivalent to Rv0248c,len: 646 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 646 aa overlap). Probable succinate dehydrogenase, flavoprotein subunit (EC 1.3.99.1), highly similar to flavoprotein subunit of various succinate dehydrogenases e.g. M88696|RIRSDHA_1 flavoprotein from Rickettsia prowazekii (596 aa), FASTA scores: opt: 651,E(): 0, (34.6 % identity in 598 aa overlap). Also similar to truncated U00022_17 flavoprotein from Mycobacterium leprae (401 aa), FASTA scores: opt: 677, E(): 0, (39.0% identity in 423 aa overlap). NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?).	Q7U2G6,A0A1R3XUR3	No	intermediary metabolism and respiration			A0A1R3XUR3				IPR003953,IPR013027,IPR015939,IPR027477	Q7U2G6					Rv0248c		Rv0248c			
NC_002945.3	Mycobrowser_v4	CDS	299159	299980	.	-	0	Mb0255c	Mb0255c		probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase)	Mb0255c, -, len: 273 aa. Equivalent to Rv0249c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Probable succinate dehydrogenase, membrane-anchor subunit for succinate dehydrogenase encoded by Rv0247c and Rv0248c. Highly similar to AC44315.1|AL596043 putative integral membrane protein from Streptomyces coelicolor (278 aa). NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?).	Q7U2G5,A0A1R3XUU1	No	intermediary metabolism and respiration			A0A1R3XUU1					Q7U2G5					Rv0249c		Rv0249c			
NC_002945.3	Mycobrowser_v4	CDS	314108	314740	.	-	0	Mb0270c	Mb0270c		CONSERVED HYPOTHETICAL PROTEIN	Mb0270c, -, len: 210 aa. Equivalent to Rv0264c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Conserved hypothetical protein, equivalent to CAC32080.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (222 aa). Also similar to others hypothetical proteins e.g. AL121596|SC51A_20 from Streptomyces coelicolor (252 aa), FASTA scores: opt: 420, E(): 2.7e-20, (41.7% identity in 204 aa overlap); P75744|YBGJ_ECOLI HYPOTHETICAL 23.9 KD PROTEIN from Escherichia coli (218 aa), FASTA scores: E(): 2.1e-14, (35.7% identity in 182 aa overlap); YH31_HAEIN|P44299|hi173 hypothetical protein from Haemophilus influenzae (213 aa), FASTA scores: opt: 252,E(): 8.3e-10, (31.1% identity in 183 aa overlap).	Q7U2F2,A0A1R3XVE4	No	conserved hypotheticals			A0A1R3XVE4				IPR003833,IPR024946	Q7U2F2					Rv0264c		Rv0264c			
NC_002945.3	Mycobrowser_v4	CDS	1886443	1887147	.	+	0	Mb1703	Mb1703		unknown protein	Mb1703, -, len: 234 aa. Equivalent to Rv1676, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 234 aa overlap). Hypothetical unknown protein.	Q7TZT4,A0A1R3XZC9	No	conserved hypotheticals			A0A1R3XZC9				IPR000866,IPR012336	Q7TZT4					Rv1676		Rv1676			
NC_002945.3	Mycobrowser_v4	CDS	309839	310984	.	-	0	Mb0266c	Mb0266c		possible transcriptional regulatory protein	Mb0266c, -, len: 381 aa. Equivalent to Rv0260c,len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 381 aa overlap). Possible two-component response regulator, highly similar to CAB72204.1|AL138851 putative transcriptional regulator from Streptomyces coelicolor (395 aa); and similar to O34394|D69851|YJJA conserved hypothetical protein from Bacillus subtilis (270 aa), FASTA scores: opt: 312, E(): 7.4e-14, (25.8% identity in 267 aa overlap). Also some similarity to regulatory proteins at C-terminal region e.g. CUTR_STRLI|Q03756 transcriptional regulatory protein (217 aa), FASTA scores: opt: 138, E(): 0.02, (30.6% identity in 111 aa overlap).	Q7U2F5,A0A1R3XUT7	No	regulatory proteins			A0A1R3XUT7				IPR001867,IPR003754,IPR011991,IPR016032	Q7U2F5					Rv0260c		Rv0260c			
NC_002945.3	Mycobrowser_v4	CDS	886262	886990	.	-	0	Mb0814c	Mb0814c		HYPOTHETICAL PROTEIN	Mb0814c, -, len: 242 aa. Equivalent to Rv0790c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Hypothetical unknown protein.	Q7U197,A0A1R3XXE8	No	conserved hypotheticals			A0A1R3XXE8				IPR002931	Q7U197					Rv0790c		Rv0790c			
NC_002945.3	Mycobrowser_v4	CDS	313189	314091	.	-	0	Mb0269c	Mb0269c		CONSERVED HYPOTHETICAL PROTEIN	Mb0269c, -, len: 300 aa. Equivalent to Rv0263c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Conserved hypothetical protein, equivalent to NP_302634.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (305 aa). Also similar to others e.g. AL121596|SC51A_21 hypothetical protein from Streptomyces coelicolor (285 aa), FASTA scores: opt: 714, E(): 0, (45.3% identity in 289 aa overlap); NP_233164.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (309 aa); NP_406216.1|NC_003143 conserved hypothetical protein from Yersinia pestis (316 aa); YH30_HAEIN|P44298|hi1730 hypothetical protein from Haemophilus influenzae (309 aa),FASTA scores: opt: 430, E(): 3e-20, (29.6% identity in 284 aa overlap); etc. Also similar to carboxylases eg NP_415240.1|NC_000913|P75745|YBGK_ECOLI putative carboxylase from Escherichia coli strain K12 (310 aa),FASTA score: (34.6% identity in 286 aa overlap); NP_459698.1|NC_003197 putative carboxylase from Salmonella typhimurium (310 aa); and to middle part of NP_420636.1|NC_002696 urea amidolyase-related protein from Caulobacter crescentus (1207 aa).	Q7U2F3,A0A1R3XUZ3	No	conserved hypotheticals			A0A1R3XUZ3				IPR003778	Q7U2F3					Rv0263c		Rv0263c			
NC_002945.3	Mycobrowser_v4	CDS	314836	315828	.	-	0	Mb0271c	Mb0271c		PROBABLE PERIPLASMIC IRON-TRANSPORT LIPOPROTEIN	Mb0271c, -, len: 330 aa. Equivalent to Rv0265c,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Probable iron-transport lipoprotein, most similar to T36412|5763945|CAB53324.1|AL109974 probable iron-siderophore binding lipoprotein from Streptomyces coelicolor (350 aa); and (N-terminus may be incorrect) to T14166|3560508|AAC82551.1|AF027770 fxuD protein from Mycobacterium smegmatis (420 aa), FASTA scores: opt: 385,E(): 1.5e-16, (32.3% identity in 232 aa overlap). Also similar to AAB97475.1|U02617 DtxR/iron regulated lipoprotein precursor from Corynebacterium diphtheriae (355 aa); FECB_ECOLI|P15028 iron(III) dicitrate-binding periplasmic protein (300 aa), FASTA scores: opt: 191, E(): 2.3e-05, (26.5% identity in 196 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as fecB2.	Q7U2F1,A0A1R3XUT9	No	cell wall and cell processes			A0A1R3XUT9				IPR002491,IPR006311	Q7U2F1					Rv0265c		Rv0265c			
NC_002945.3	Mycobrowser_v4	CDS	321663	322856	.	-	0	Mb0275c	Mb0275c		CONSERVED HYPOTHETICAL PROTEIN	Mb0275c, -, len: 397 aa. Equivalent to Rv0269c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Conserved hypothetical protein, highly similar to AL079355|SC4C6_19 hypothetical protein from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1019, E(): 0, (46.5% identity in 344 aa overlap), and similar to other proteins e.g. CAC49016.1|AL603644 putative ATP-dependent DNA ligase protein from Sinorhizobium meliloti (636 aa); O34398 YKOU PROTEIN from Bacillus subtilis (611 aa), FASTA score: (27.2% identity in 283 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3062,Rv3731 (both DNA ligases), and Rv0938, Rv3730c.	Q7U2E7,A0A1R3XUV8	No	conserved hypotheticals			A0A1R3XUV8				IPR002755	Q7U2E7					Rv0269c		Rv0269c			
NC_002945.3	Mycobrowser_v4	CDS	1455607	1456260	.	+	0	Mb1333	Mb1333		conserved protein	Mb1333, -, len: 217 aa. Equivalent to Rv1301, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Conserved hypothetical protein, highly similar to YRFE_MYCLE|P45831 hypothetical 22.7 kd protein in rfe-hemk intergenic region, (220 aa),FASTA scores: opt: 1168, E(): 0, (82.8% identity in 215 aa overlap). Contains PS01147 Hypothetical SUA5/yciO/yrdC family signature. BELONGS TO THE SUA5/YRDC/YCIO/YWLC FAMILY.	Q7U085,A0A1R3XXY6	No	conserved hypotheticals			A0A1R3XXY6				IPR006070,IPR017945	Q7U085					Rv1301		Rv1301			
NC_002945.3	Mycobrowser_v4	CDS	326900	328033	.	-	0	Mb0278c	Mb0278c		unknown protein	Mb0278c, -, len: 377 aa. Equivalent to Rv0272c,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 377 aa overlap). Hypothetical unknown protein.	Q7U2E4,A0A1R3XVX7	No	conserved hypotheticals			A0A1R3XVX7					Q7U2E4					Rv0272c		Rv0272c			
NC_002945.3	Mycobrowser_v4	CDS	419322	419975	.	+	0	Mb0356	Mb0356		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0356, -, len: 217 aa. Equivalent to Rv0348, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Possible transcriptional regulator, showing some similarity to O53334|RV3188|MTV014.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (115 aa), FASTA score: (30.0% identity in 100 aa overlap). Contains probable helix-turn helix motif from aa 89-110 (Score 1407, +3.98 SD).	Q7U274,A0A1R3XV12	No	regulatory proteins			A0A1R3XV12					Q7U274					Rv0348		Rv0348			
NC_002945.3	Mycobrowser_v4	CDS	342000	342908	.	+	0	Mb0289	Mb0289		possible s-adenosylmethionine-dependent methyltransferase	Mb0289, -, len: 302 aa. Equivalent to Rv0281, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Conserved hypothetical protein; member of Mycobacterium tuberculosis protein family that includes Rv0726c, Rv0731c, Rv3399,Rv1729c, etc. MTCY31_23 (325 aa), FASTA scores: opt: 1386,E(): 0, (69. 1% identity in 301 aa overlap). Contains possible N-terminal signal sequence.	X2BEG3,Q7U2D4,Q7U2D4	No	lipid metabolism			Q7U2D4					X2BEG3,Q7U2D4					Rv0281		Rv0281			
NC_002945.3	Mycobrowser_v4	CDS	2130400	2130711	.	+	0	Mb1925	Mb1925		PROBABLE MEMBRANE PROTEIN	Mb1925, -, len: 103 aa. Equivalent to Rv1892, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Probable membrane protein.	Q7TZC5,A0A1R3XZP7	No	cell wall and cell processes			A0A1R3XZP7					Q7TZC5					Rv1892		Rv1892			
NC_002945.3	Mycobrowser_v4	CDS	4320326	4320775	.	-	0	Mb3931c	Mb3931c		POSSIBLE MEMBRANE PROTEIN	Mb3931c, -, len: 149 aa. Equivalent to Rv3901c,len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 149 aa overlap). Possible membrane protein (hydrophobic stretch from ~30-52), showing some similarity with O53200|Rv2473|MTV008.29 HYPOTHETICAL 25.1 KDA PROTEIN from Mycobacterium tuberculosis (238 aa),FASTA scores: opt: 147, E(): 0.036, (31.35% identity in 134 aa overlap).	Q7TVE0,A0A1R3Y5K8	No	cell wall and cell processes			A0A1R3Y5K8					Q7TVE0					Rv3901c		Rv3901c			
NC_002945.3	Mycobrowser_v4	CDS	357864	359066	.	-	0	Mb0301c	Mb0301c		conserved protein	Mb0301c, -, len: 400 aa. Equivalent to Rv0293c,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 400 aa overlap). Conserved hypothetical protein, similar in C-terminal part to Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (413 aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity in 299 aa overlap). TBparse score is 0.922.	Q7U2C3,A0A1R3XVG5	No	conserved hypotheticals			A0A1R3XVG5					Q7U2C3					Rv0293c		Rv0293c			
NC_002945.3	Mycobrowser_v4	CDS	359947	360750	.	-	0	Mb0303c	Mb0303c		conserved protein	Mb0303c, -, len: 267 aa. Equivalent to Rv0295c,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 267 aa overlap). Conserved hypothetical protein, showing weak similarity with CAC46877.1|AL591790 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (213 aa); and NP_104818.1|14023999|BAB50604.1|AP00300 Protein with weak similarity to NodH from Mesorhizobium loti (257 aa).	Q7U2C2,A0A1R3XUW4	No	conserved hypotheticals			A0A1R3XUW4				IPR015124,IPR024628,IPR027417	Q7U2C2					Rv0295c		Rv0295c			
NC_002945.3	Mycobrowser_v4	CDS	387335	388129	.	-	0	Mb0326c	Mb0326c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0326c, -, len: 264 aa. Equivalent to Rv0318c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable conserved integral membrane protein, with some similarity to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: opt: 157, E (): 0.0032, (28.3% identity in 198 aa overlap). Also similar to O26573 CONSERVED PROTEIN from Methanobacterium thermoauto (259 aa), FASTA scores: opt: 173, E(): 5.2e-05, (32.7% identity in 214 aa overlap).	Q7U299,A0A1R3XV09	No	cell wall and cell processes			A0A1R3XV09				IPR003689	Q7U299					Rv0318c		Rv0318c			
NC_002945.3	Mycobrowser_v4	CDS	470610	471032	.	+	0	Mb0396	Mb0396		conserved protein	Mb0396, -, len: 140 aa. Equivalent to Rv0390, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein from Mycobacterium leprae (147 aa), FASTA scores: opt: 778, E(): 0, (79.0% identity in 138 aa overlap). Also similar to hypothetical proteins from several Rickettsia species.	Q7U240,A0A1R3XV62	No	conserved hypotheticals			A0A1R3XV62				IPR001763	Q7U240					Rv0390		Rv0390			
NC_002945.3	Mycobrowser_v4	CDS	360760	362157	.	-	0	Mb0304c	Mb0304c		PROBABLE SULFATASE	Mb0304c, -, len: 465 aa. Equivalent to Rv0296c,len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 465 aa overlap). Probable sulfatase,possibly an aryl-/steryl-sulfatase (EC 3.1.6.-) or a sulfamidase (sulfohydrolase) (sulphamidase) (EC 3.10.1.-). Similar to various hydrolases e.g. AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus musculus (502 aa); NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 N-sulfoglucosamine sulfohydrolase (sulfamidase) (sulphamidase) from Mus musculus (502 aa); AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC) from Homo sapiens (583 aa); ARSB_FELCA|P33727 arylsulfatase B precursor (EC 3.1.6.1) (535 aa), FASTA scores: opt: 231, E(): 1.7e-08, (30.3% identity in 261 aa overlap). Also similarity with 4 others sulfatases in Mycobacterium tuberculosis. Contains sulfatases signature 1 (PS00523). Note that previously known as atsG.	Q7U2C1,A0A1R3XUX0	No	intermediary metabolism and respiration			A0A1R3XUX0				IPR000917,IPR017849,IPR017850,IPR024607	Q7U2C1					Rv0296c		Rv0296c			
NC_002945.3	Mycobrowser_v4	CDS	364299	364526	.	+	0	Mb0306	Mb0306		HYPOTHETICAL PROTEIN	Mb0306, -, len: 75 aa. Equivalent to Rv0298, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Hypothetical unknown protein.	Q7U2B9,A0A1R3XUY8	No	conserved hypotheticals			A0A1R3XUY8				IPR002145	Q7U2B9					Rv0298		Rv0298			
NC_002945.3	Mycobrowser_v4	CDS	365652	366284	.	+	0	Mb0310	Mb0310		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY)	Mb0310, -, len: 210 aa. Equivalent to Rv0302, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 210 aa overlap). Probable transcription regulatory protein, TetR family, with its N-terminus similar to N-terminus of several repressors and regulatory proteins of TetR/AcrR family e.g. ACRR_ECOLI|P34000 potential acraB operon repressor from Escherichia coli (215 aa), FASTA scores: opt: 172, E(): 3.1e-05, (22.7% identity in 194 aa overlap). Also similar in N-terminus to N-terminus of MTCY07A7.24 hypothetical regulator from Mycobacterium tuberculosis FASTA score: (38.7% identity in 62 aa overlap). Contains probable helix-turn helix motif from aa 35-56 (Score 1728, +5.07 SD).	Q7U2B5,A0A1R3XV48	No	regulatory proteins			A0A1R3XV48				IPR001647,IPR009057,IPR011075,IPR015893	Q7U2B5					Rv0302		Rv0302			
NC_002945.3	Mycobrowser_v4	CDS	366281	367189	.	+	0	Mb0311	Mb0311		PROBABLE DEHYDROGENASE/REDUCTASE	Mb0311, -, len: 302 aa. Equivalent to Rv0303, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various NADPH dehydrogenases and other NADPH oxidoreductases e.g. O48741|PORC_ARATH|7488284|T00897 PROTOCHLOROPHYLLIDE REDUCTASE C CHLOROPLAST PRECURSOR (EC 1.3.1.33) (NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE C) from Arabidopsis thaliana (401 aa); Q42850 NADPH DEHYDROGENASE (EC 1.6.99. 1) (395 aa), FASTA scores: opt: 347, E(): 3.8e-16, (35.4% identity in 319 aa overlap).	Q7U2B4,A0A1R3XVH5	No	intermediary metabolism and respiration			A0A1R3XVH5				IPR002198,IPR002347,IPR016040	Q7U2B4					Rv0303		Rv0303			
NC_002945.3	Mycobrowser_v4	CDS	376944	377615	.	+	0	Mb0314	Mb0314		PUTATIVE OXIDOREDUCTASE	Mb0314, -, len: 223 aa. Equivalent to Rv0306, len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Putative oxidoreductase (EC 1.-.-.-), highly similar to H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved hypothetical protein from Pseudomonas aeruginosa strain PAO1 (218 aa); and to other putative oxidoreductases e.g. middle part of CAB76073.1|AL157953 putative nitroreductase from Streptomyces coelicolor (1212 aa); Q52685|BLUB protein involved in cobalamin (vitamin B12) synthesis from Rhodobacter capsulatus (206 aa), FASTA scores: opt: 318,E(): 2e-15, (35.6% identity in 191 aa overlap).	Q7U2B1,A0A1R3XUY2	No	intermediary metabolism and respiration			A0A1R3XUY2				IPR000415,IPR012825	Q7U2B1					Rv0306		Rv0306			
NC_002945.3	Mycobrowser_v4	CDS	377603	378085	.	-	0	Mb0315c	Mb0315c		unknown protein	Mb0315c, -, len: 160 aa. Equivalent to Rv0307c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein.	Q7U2B0,A0A1R3XUX3	No	conserved hypotheticals			A0A1R3XUX3					Q7U2B0					Rv0307c		Rv0307c			
NC_002945.3	Mycobrowser_v4	CDS	378143	378859	.	+	0	Mb0316	Mb0316		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0316, -, len: 238 aa. Equivalent to Rv0308, len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Probable conserved integral membrane protein, with C-terminus highly similar to C-terminus of other integral membrane proteins or phosphatases e.g. AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 putative phosphatase from Streptococcus pyogenes (201 aa); Q06074 HYPOTHETICAL 24.9 KD PROTEIN (216 aa), FASTA scores: opt: 209, E(): 2e-07, (27.9% identity in 140 aa overlap). Could be a phosphatase.	Q7U2A9,A0A1R3XUZ9	No	cell wall and cell processes			A0A1R3XUZ9				IPR000326	Q7U2A9					Rv0308		Rv0308			
NC_002945.3	Mycobrowser_v4	CDS	378961	379617	.	+	0	Mb0317	Mb0317		POSSIBLE CONSERVED EXPORTED PROTEIN	Mb0317, -, len: 218 aa. Equivalent to Rv0309, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Possible conserved exported protein (has putative N-terminal signal sequence), equivalent to AC32053.1|AL583926 putative secreted protein from Mycobacterium leprae (218 aa). Also similar to others e.g. AB76092.1|AL157956 putative secreted protein from Streptomyces coelicolor (238 aa).	Q7U2A8,A0A1R3XUY9	No	cell wall and cell processes			A0A1R3XUY9				IPR005490	Q7U2A8					Rv0309		Rv0309			
NC_002945.3	Mycobrowser_v4	CDS	379687	380178	.	-	0	Mb0318c	Mb0318c		conserved protein	Mb0318c, -, len: 163 aa. Equivalent to Rv0310c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 BILE ACID-INDUCIBLE OPERON PROTEIN E from Eubacterium sp (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% identity in 134 aa overlap); AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa).	Q7U2A7,A0A1R3XX43	No	conserved hypotheticals			A0A1R3XX43					Q7U2A7					Rv0310c		Rv0310c			
NC_002945.3	Mycobrowser_v4	CDS	381586	383448	.	+	0	Mb0320	Mb0320		CONSERVED HYPOTHETICAL PROLINE AND THREONINE RICH PROTEIN	Mb0320, -, len: 620 aa. Equivalent to Rv0312, len: 620 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 620 aa overlap). Conserved hypothetical protein with highly Pro-, Thr-rich C-terminus. Similar to Pro-,Thr-rich region in Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis (592 aa), FASTA scores: opt: 1075, E(): 0, (38.9% identity in 627 aa overlap). Also some similarity with Rv0350|dnaK from Mycobacterium tuberculosis. Possibly membrane protein; has hydrophobic stetch in its middle part.	Q7U2A5,A0A1R3XV58	No	conserved hypotheticals			A0A1R3XV58				IPR013126	Q7U2A5					Rv0312		Rv0312			
NC_002945.3	Mycobrowser_v4	CDS	388918	389580	.	+	0	Mb0328	Mb0328		POSSIBLE CONSERVED EXPORTED PROTEIN	Mb0328, -, len: 220 aa. Equivalent to Rv0320, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Possible conserved exported protein, similar to some hypothetical proteins and to the middle part of a peptidase: NP_066789.1|10657900|AAG21739.1|AF116907 putative peptidase from Rhodococcus equi (546 aa). Also similar to Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity in 225 aa overlap).	Q7U298,A0A1R3XX50	No	cell wall and cell processes			A0A1R3XX50					Q7U298					Rv0320		Rv0320			
NC_002945.3	Mycobrowser_v4	CDS	391610	392281	.	-	0	Mb0331c	Mb0331c		CONSERVED HYPOTHETICAL PROTEIN	Mb0331c, -, len: 223 aa. Equivalent to Rv0323c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 223 aa overlap). Conserved hypothetical protein, similar to others e.g. YPJG_BACSU|P42981 hypothetical 24.8 kd protein from Bacillus subtilis (224 aa), FASTA scores: opt: 182, E(): 1.3e-05, (27.5% identity in 211 aa overlap). Also some similarity to MLU15183_8 from Mycobacterium tuberculosis FASTA score: (32.0% identity in 147 aa overlap).	Q7U295,A0A1R3XVI7	No	conserved hypotheticals			A0A1R3XVI7				IPR003737,IPR024078	Q7U295					Rv0323c		Rv0323c			
NC_002945.3	Mycobrowser_v4	CDS	392382	393062	.	+	0	Mb0332	Mb0332		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY)	Mb0332, -, len: 226 aa. Equivalent to Rv0324, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Possible transcriptional regulator, arsR family, with its N-terminus similar to the N-terminus of other DNA-binding proteins e.g. P30346|MERR_STRLI probable mercury resistance operon from Streptomyces lividans (125 aa),FASTA scores: opt: 154, E(): 0.002, (32.2% identity in 90 aa overlap)), and its C-terminal part similar to hypothetical bacterial proteins e.g. P54510|YQHL_BACSU hypothetical 14.6 kd protein from Bacillus subtilis (126 aa), FASTA scores: opt: 159, E(): 0.00097, (35.5% identity in 76 aa overlap)). Most similar to AJ005575|SPE005575_2 ORF1 required for antibiotic production from Streptomyces peucetius (226 aa), FASTA scores: opt: 816, E(): 0, (60.7% identity in 211 aa overlap). Also similar in C-terminus to MTCY164.26 molybdopterin biosynthesis moeb protein from Mycobacterium tuberculosis FASTA score: (36.8% identity in 114 aa overlap).	Q7U294,A0A1R3XV01	No	regulatory proteins	2KKO,3GW2		A0A1R3XV01				IPR001307,IPR001763,IPR001845,IPR011991	Q7U294					Rv0324		Rv0324			
NC_002945.3	Mycobrowser_v4	CDS	393069	393758	.	+	0	Mb0333	Mb0333		HYPOTHETICAL PROTEIN	Mb0333, -, len: 229 aa. Equivalent to Rv0325 and Rv0326, len: 74 aa and 151 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 aa overlap and 100.0% identity in 151 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (t-c) leads to single product.	Q7U293,A0A1R3XUZ2	No	unknown			A0A1R3XUZ2				IPR013216	Q7U293					Rv0325		Rv0325			
NC_002945.3	Mycobrowser_v4	CDS	416217	416489	.	+	0	Mb0353	Mb0353		CONSERVED HYPOTHETICAL PROTEIN	Mb0353, -, len: 90 aa. Equivalent to 3' end of Rv0345, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 188, E(): 1.5e-05, (41.0% identity in 117 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U276,A0A1R3XV20	No				A0A1R3XV20				IPR025877	Q7U276										
NC_002945.3	Mycobrowser_v4	CDS	2048711	2049415	.	+	0	Mb1846	Mb1846		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1846, -, len: 234 aa. Equivalent to Rv1816, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Possible transcriptional regulatory protein. MEME analysis suggests similarity to putative Mycobacterium tuberculosis transcriptional regulators, Rv0653c, Rv0681. Contains helix-turn-helix motif at aa 38-59 (+4.30 SD).	X2BJA0,P67439,P67439	No	regulatory proteins			P67439					X2BJA0,P67439					Rv1816		Rv1816			
NC_002945.3	Mycobrowser_v4	CDS	395141	395743	.	+	0	Mb0335	Mb0335		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR/ACRR-FAMILY)	Mb0335, -, len: 200 aa. Equivalent to Rv0328, len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Possible transcription regulator, tetR/acrR family, similar in part to various hypothetical transcriptional regulators e.g. T36696|4726006|CAB41735.1|AL049731 probable regulatory protein from Streptomyces coelicolor (197 aa). Also some similarity with YX44_MYCTU|Q10829 hypothetical transcriptional regulator from Mycobacterium tuberculosis (195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7% identity in 202 aa overlap). Contains probable helix-turn helix motif from aa 27-48 (Score 1408, +3.98 SD). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7U291,A0A1R3XUZ6	No	regulatory proteins			A0A1R3XUZ6				IPR001647,IPR009057,IPR011075,IPR015893	Q7U291					Rv0328		Rv0328			
NC_002945.3	Mycobrowser_v4	CDS	395724	396350	.	-	0	Mb0336c	Mb0336c		CONSERVED HYPOTHETICAL PROTEIN	Mb0336c, -, len: 208 aa. Equivalent to Rv0329c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 208 aa overlap). Conserved hypothetical protein, showing some similarity with others hypothetical proteins and methyltransferases e.g. MitM|AF127374_14 methyltransferase from Streptomyces lavendulae (283 aa),FASTA scores: opt: 242, E(): 1.8e-08, (37.2% identity in 145 aa overlap); Q48938 from Methanosarcina barkeri (262 aa), FASTA scores: opt: 194, E(): 3.6e-06, (31.1% identity in 119 aa overlap).	Q7U290,A0A1R3XV18	No	conserved hypotheticals			A0A1R3XV18				IPR013216	Q7U290					Rv0329c		Rv0329c			
NC_002945.3	Mycobrowser_v4	CDS	397231	398397	.	+	0	Mb0338	Mb0338		POSSIBLE DEHYDROGENASE/REDUCTASE	Mb0338, -, len: 388 aa. Equivalent to Rv0331, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein reductase from Mesorhizobium loti (377 aa); NP_147681.1 predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% identity in 348 aa overlap). TBparse score is 0.906.	Q7U288,A0A1R3XX61	No	intermediary metabolism and respiration			A0A1R3XX61				IPR013027,IPR015904,IPR023753	Q7U288					Rv0331		Rv0331			
NC_002945.3	Mycobrowser_v4	CDS	398472	399257	.	+	0	Mb0339	Mb0339		conserved protein	Mb0339, -, len: 261 aa. Equivalent to Rv0332, len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 261 aa overlap). Conserved hypothetical protein, similar to several conserved hypothetical proteins from Streptomyces coelicolor e.g. SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% identity in 251 aa overlap).	Q7U287,A0A1R3XW40	No	conserved hypotheticals			A0A1R3XW40				IPR010872,IPR017517,IPR024344	Q7U287					Rv0332		Rv0332			
NC_002945.3	Mycobrowser_v4	CDS	399284	399658	.	+	0	Mb0340	Mb0340		unknown protein	Mb0340, -, len: 124 aa. Equivalent to Rv0333, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Hypothetical unknown protein.	Q7U286,A0A1R3XV78	No	conserved hypotheticals			A0A1R3XV78				IPR009959	Q7U286					Rv0333		Rv0333			
NC_002945.3	Mycobrowser_v4	CDS	401222	402733	.	+	0	Mb0343	Mb0343		CONSERVED 13E12 REPEAT FAMILY PROTEIN	Mb0343, -, len: 503 aa. Equivalent to Rv0336, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Part of Mycobacterium tuberculosis 13E12 repeat family; almost identical to Rv0515|MTCY20G10.05 hypothetical protein from M. tuberculosis FASTA scores: (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1148c, Rv1945, etc.	Q7TTD9,A0A0G2QBY8	No	insertion seqs and phages			A0A0G2QBY8				IPR003615,IPR003870	Q7TTD9					Rv0336		Rv0336			
NC_002945.3	Mycobrowser_v4	CDS	404223	406871	.	-	0	Mb0345c	Mb0345c		probable iron-sulfur-binding reductase	Mb0345c, -, len: 882 aa. Equivalent to Rv0338c,len: 882 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 882 aa overlap). Probable iron-sulphur-binding reductase (EC 1.-.-.-), possibly membrane-bound, equivalent to CAC32018.1|AL583925 probable iron-sulphur-binding reductase from Mycobacterium leprae (880 aa). Also highly similar to others e.g. T36608|5019323|CAB44376.1|AL078610 probable iron-sulfur-binding reductase from Streptomyces coelicolor (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity in 772 aa overlap); BAB07521.1|AP001520 iron-sulphur-binding reductase from Bacillus halodurans (700 aa). Contains PS00070 Aldehyde dehydrogenases cysteine active site and two of PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. First of several possible start sites chosen.	Q7U283,A0A1R3XV03	No	intermediary metabolism and respiration			A0A1R3XV03				IPR004017,IPR009051,IPR017896,IPR017900	Q7U283					Rv0338c		Rv0338c			
NC_002945.3	Mycobrowser_v4	CDS	406980	409478	.	-	0	Mb0346c	Mb0346c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0346c, -, len: 832 aa. Equivalent to Rv0339c,len: 832 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 832 aa overlap). Possible transcriptional regulator, showing very weak similarity with parts of others. Contains PS00017 ATP/GTP-binding site motif A (P-loop ); and probable helix-turn helix motif from aa 778-799 (Score 1041, +2.73 SD).	Q7U282,A0A1R3XV26	No	regulatory proteins			A0A1R3XV26				IPR000792,IPR011991,IPR016032,IPR027417	Q7U282					Rv0339c		Rv0339c			
NC_002945.3	Mycobrowser_v4	CDS	409664	410203	.	+	0	Mb0347	Mb0347		conserved protein	Mb0347, -, len: 179 aa. Equivalent to Rv0340, len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Conserved hypothetical protein; MEME-MAST analysis shows similarity to product of downstream gene, Rv0341|iniB.	Q7U281,A0A1R3XV19	No	conserved hypotheticals			A0A1R3XV19					Q7U281					Rv0340		Rv0340			
NC_002945.3	Mycobrowser_v4	CDS	418333	419319	.	+	0	Mb0355	Mb0355		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0355, -, len: 328 aa. Equivalent to Rv0347, len: 328 aa (alternative start possible), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 328 aa overlap). Probable conserved membrane protein, similar to Rv0831c|AL022004|MTV043_23 from Mycobacterium tuberculosis (271 aa), FASTA scores: E(): 9.6e-21, (33.1% identity in 266 aa overlap).	Q7U275,A0A1R3XV29	No	cell wall and cell processes			A0A1R3XV29				IPR026349	Q7U275					Rv0347		Rv0347			
NC_002945.3	Mycobrowser_v4	CDS	435847	436491	.	-	0	Mb0363c	Mb0363c		conserved protein	Mb0363c, -, len: 214 aa. Equivalent to Rv0356c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1067, E(): 0, (73.4% identity in 214 aa overlap).	Q7U269,A0A1R3XV30	No	conserved hypotheticals			A0A1R3XV30				IPR006683	Q7U269					Rv0356c		Rv0356c			
NC_002945.3	Mycobrowser_v4	CDS	443412	444095	.	+	0	Mb0371	Mb0371		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0371, -, len: 227 aa. Equivalent to Rv0364, len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 227 aa overlap). Possible conserved transmembrane protein, equivalent to O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLCB 4_19 HYPOTHETICAL 24.3 KDA PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1% identity in 227 aa overlap). Shows strong similarity to DEDA_ECOLI|P09548 DedA PROTEIN protein from Escherichia coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa overlap). Similar also to Mycobacterium tuberculosis DedA protein Rv2637|MTCY441.0.	Q7U263,A0A1R3XVA9	No	cell wall and cell processes			A0A1R3XVA9				IPR015414	Q7U263					Rv0364		Rv0364			
NC_002945.3	Mycobrowser_v4	CDS	1015332	1015766	.	+	0	Mb0934	Mb0934		CONSERVED HYPOTHETICAL PROTEIN	Mb0934, -, len: 144 aa. Equivalent to Rv0910, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved hypothetical protein, equivalent to NP_302398.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa),FASTA scores: opt: 820, E(): 0, (83.9% identity in 143 aa overlap). Also similar to Rv1546|MTCY48.19c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (143 aa).	Q7U119,A0A1R3XYW4	No	conserved hypotheticals			A0A1R3XYW4				IPR019587,IPR023393	Q7U119					Rv0910		Rv0910			
NC_002945.3	Mycobrowser_v4	CDS	437877	438524	.	+	0	Mb0365	Mb0365		conserved protein	Mb0365, -, len: 215 aa. Equivalent to Rv0358, len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Conserved hypothetical protein, highly similar to AL023514|MLCB4_14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 852, E(): 0, (62.9% identity in 229 aa overlap).	Q7U268,A0A1R3XV37	No	conserved hypotheticals			A0A1R3XV37					Q7U268					Rv0358		Rv0358			
NC_002945.3	Mycobrowser_v4	CDS	438535	439314	.	+	0	Mb0366	Mb0366		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0366, -, len: 259 aa. Equivalent to Rv0359, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 259 aa overlap). Probable conserved integral membrane protein, highly similar to hypothetical or other membrane proteins e.g. AL133220|SCC75A_6|T50569 probable membrane protein from Streptomyces coelicolor (265 aa), FASTA scores: opt: 642, E(): 0, (43.1% identity in 248 aa overlap); P70995 HYPOTHETICAL 24.7 KD PROTEIN from Bacillus subtilis (219 aa), FASTA scores: E(): 1.5e-12, (31.3% identity in 192 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142).	Q7U267,A0A1R3XV22	No	cell wall and cell processes			A0A1R3XV22				IPR008915	Q7U267					Rv0359		Rv0359			
NC_002945.3	Mycobrowser_v4	CDS	439319	439756	.	-	0	Mb0367c	Mb0367c		conserved protein	Mb0367c, -, len: 145 aa. Equivalent to Rv0360c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Conserved hypothetical protein, equivalent to AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c hypothetical protein from Mycobacterium leprae (137 aa),FASTA scores: opt: 793, E(): 0, (85.4% identity in 137 aa overlap). And similar to AL049754|SCH10_25c|T36537 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity in 138 aa overlap).	Q7U266,A0A1R3XV42	No	conserved hypotheticals			A0A1R3XV42				IPR014487	Q7U266					Rv0360c		Rv0360c			
NC_002945.3	Mycobrowser_v4	CDS	439839	440666	.	+	0	Mb0368	Mb0368		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0368, -, len: 275 aa. Equivalent to Rv0361, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable conserved membrane protein (has hydrophobic stretch from residues 132-156), equivalent to AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane protein from Mycobacterium leprae (292 aa), FASTA scores: opt: 1044, E(): 0, (58.6% identity in 292 aa overlap).	Q7U265,A0A1R3XV36	No	cell wall and cell processes			A0A1R3XV36					Q7U265					Rv0361		Rv0361			
NC_002945.3	Mycobrowser_v4	CDS	705720	705917	.	-	0	Mb0626A	Mb0626A		HYPOTHETICAL PROTEIN	Mb0626A, -, len:65 aa. Equivelent to a conserved protein of unknown function YP_007259328 from Mycobacterium canettii strain CIPT 140060008 (99% with 64 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb0626A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BFI6,UPI0001900F98	No				UPI0001900F98					X2BFI6										
NC_002945.3	Mycobrowser_v4	CDS	444084	445214	.	-	0	Mb0372c	Mb0372c		conserved protein	Mb0372c, -, len: 376 aa. Equivalent to Rv0365c,len: 376 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 376 aa overlap). Conserved hypothetical protein, very similar to G388212|CAA35191.1, a truncated ORF immediately upstream of the Corynebacterium glutamicum fda gene encoding fructose-1,6-biphosphate aldolase (304 aa), FASTA scores: E(): 7.1e-19, (42.2% identity in 296 aa overlap).	Q7U262,A0A1R3XVN4	No	conserved hypotheticals			A0A1R3XVN4				IPR005198,IPR008928,IPR012341,IPR014512	Q7U262					Rv0365c		Rv0365c			
NC_002945.3	Mycobrowser_v4	CDS	1208743	1209009	.	+	0	Mb1112	Mb1112		CONSERVED HYPOTHETICAL PROTEIN	Mb1112, -, len: 88 aa. Equivalent to Rv1083, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 88 aa overlap). Conserved hypothetical protein, similar to U15183|MLU15183_9 hypothetical protein from Mycobacterium leprae (167 aa), FASTA scores: opt: 332, E(): 1.2e-13, (58.4% identity in 101 aa overlap). Hydrophobic domain aa 25-43.	Q7U0Q0,A0A1R3XXB1	No	conserved hypotheticals			A0A1R3XXB1					Q7U0Q0					Rv1083		Rv1083			
NC_002945.3	Mycobrowser_v4	CDS	445239	445832	.	-	0	Mb0373c	Mb0373c		CONSERVED HYPOTHETICAL PROTEIN	Mb0373c, -, len: 197 aa. Equivalent to Rv0366c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Conserved hypothetical protein, showing weak similarity to HI1395|P44173|YD95_HAEIN HYPOTHETICAL PROTEIN from Haemophilus influenzae (140 aa), FASTA scores: opt: 152,E(): 0.0015, (27.0% identity in 126 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 Glycine radical signature.	Q7U261,A0A1R3XV38	No	conserved hypotheticals			A0A1R3XV38				IPR010488,IPR027417	Q7U261					Rv0366c		Rv0366c			
NC_002945.3	Mycobrowser_v4	CDS	446331	447542	.	-	0	Mb0375c	Mb0375c		CONSERVED HYPOTHETICAL PROTEIN	Mb0375c, -, len: 403 aa. Equivalent to Rv0368c,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 403 aa overlap). Conserved hypothetical protein, showing some similarity to AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium japonicum (422 aa),FASTA scores: opt: 341, E(): 4.3e-13, (27.4% identity in 387 aa overlap); Rv2425c|MTCY428_22 hypothetical protein from Mycobacterium tuberculosis FASTA score: (30.7% identity in 238 aa overlap). Contains PS00213 Lipocalin signature.	Q7U259,A0A1R3XV44	No	conserved hypotheticals			A0A1R3XV44				IPR002035,IPR008912,IPR011195	Q7U259					Rv0368c		Rv0368c			
NC_002945.3	Mycobrowser_v4	CDS	447548	448063	.	-	0	Mb0376c	Mb0376c		POSSIBLE MEMBRANE OXIDOREDUCTASE	Mb0376c, -, len: 171 aa. Equivalent to Rv0369c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Possible membrane protein oxidoreductase (EC 1.-.-.-), similar to ORF 4 of the Pseudomonas thermocarboxydovorans protein of cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from Pseudomonas thermocarboxydovorans (171 aa), FASTA scores: opt: 226, E(): 9.8e-08, (31.3% identity in 166 aa overlap). Also similar to MTV036.05, MTV036.08, MTV036.09,and MTV026.10.	Q7U258,A0A1R3XV31	No	intermediary metabolism and respiration			A0A1R3XV31				IPR010419,IPR023393	Q7U258					Rv0369c		Rv0369c			
NC_002945.3	Mycobrowser_v4	CDS	448164	449060	.	-	0	Mb0377c	Mb0377c		POSSIBLE OXIDOREDUCTASE	Mb0377c, -, len: 298 aa. Equivalent to Rv0370c,len: 298 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 298 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many hypothetical proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL gene cluster from Pseudomonas/Oligotropha carboxidovorans (295 aa), FASTA scores: opt: 851, E(): 0, (48.2% identity in 282 aa overlap); AJ224684|BJAJ4684_3 cooxS from Bradyrhizobium japonicum (302 aa), FASTA scores: opt: 881, E(): 0, (47.6% identity in 290 aa overlap). Also highly similar to MTCY428_21 from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U257,A0A1R3XV49	No	intermediary metabolism and respiration			A0A1R3XV49				IPR003593,IPR011704,IPR027417	Q7U257					Rv0370c		Rv0370c			
NC_002945.3	Mycobrowser_v4	CDS	477413	477661	.	+	0	Mb0403A	Mb0403A		Conserved protein	Mb0403A, len: 82 aa. Equivalent to Rv0397A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BEX9,A0A1R3XV81	No	conserved hypotheticals			A0A1R3XV81					X2BEX9					Rv0397A		Rv0397A			
NC_002945.3	Mycobrowser_v4	CDS	449057	449650	.	-	0	Mb0378c	Mb0378c		CONSERVED HYPOTHETICAL PROTEIN	Mb0378c, -, len: 197 aa. Equivalent to Rv0371c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 247, E(): 4.5e-09, (32.3% identity in 195 aa overlap). Also weak similarity with YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE from Bacillus subtilis (197 aa), FASTA scores: opt: 217,E(): 2.5e-08, (27.0% identity in 174 aa overlap).	Q7U256,A0A1R3XV43	No	conserved hypotheticals			A0A1R3XV43				IPR025877	Q7U256					Rv0371c		Rv0371c			
NC_002945.3	Mycobrowser_v4	CDS	449647	450402	.	-	0	Mb0379c	Mb0379c		CONSERVED HYPOTHETICAL PROTEIN	Mb0379c, -, len: 251 aa. Equivalent to Rv0372c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Conserved hypothetical protein, showing some similarity with CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1% identity in 95 aa overlap). Also similar to upstream ORF Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap).	Q7U255,A0A1R3XXA1	No	conserved hypotheticals			A0A1R3XXA1				IPR003777,IPR027051	Q7U255					Rv0372c		Rv0372c			
NC_002945.3	Mycobrowser_v4	CDS	480808	481179	.	+	0	Mb0407	Mb0407		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0407, -, len: 123 aa. Equivalent to Rv0401, len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 123 aa overlap). Probable conserved transmembrane protein, equivalent to AL023514|MLCB4_9 putative integral membrane protein from Mycobacterium leprae (122 aa), FASTA scores: opt: 548, E(): 4.4e-32,(66.9% identity in 121 aa overlap).	Q7U229,A0A1R3XV76	No	cell wall and cell processes			A0A1R3XV76				IPR021414	Q7U229					Rv0401		Rv0401			
NC_002945.3	Mycobrowser_v4	CDS	450421	452820	.	-	0	Mb0380c	Mb0380c		PROBABLE CARBON MONOXYDE DEHYDROGENASE (LARGE CHAIN)	Mb0380c, -, len: 799 aa. Equivalent to Rv0373c,len: 799 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 799 aa overlap). Probable carbon monoxide dehydrogenase, large chain (EC 1.2.99.2), highly similar to others e.g. AAD00363.1| U80806|CUTL carbon monoxide dehydrogenase large subunit CutL protein from Hydrogenophaga pseudoflava (803 aa); S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cut operon) from Pseudomonas thermocarboxydovorans (842 aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cluster coxMSL) from Pseudomonas/Oligotropha carboxydovorans (809 aa), FASTA scores: opt: 2484, E(): 0,(56.0% identity in 804 aa overlap); etc.	Q7U254,A0A1R3XW79	No	intermediary metabolism and respiration			A0A1R3XW79				IPR000674,IPR008274,IPR012780	Q7U254					Rv0373c		Rv0373c			
NC_002945.3	Mycobrowser_v4	CDS	452817	453296	.	-	0	Mb0381c	Mb0381c		PROBABLE CARBON MONOXYDE DEHYDROGENASE (SMALL CHAIN)	Mb0381c, -, len: 159 aa. Equivalent to Rv0374c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable carbon monoxide dehydrogenase, small chain (EC 1.2.99.2), highly similar to others e.g. B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA scores: opt: 662, E(): 0, (59.3% identity in 150 aa overlap); CAA12063.1|AJ224684 putative carbon monoxide dehydrogenase small subunit from Bradyrhizobium japonicum (161 aa); S49123|509390|CAA54901.1|X77931|CUTC carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (163 aa); etc.	Q7U253,A0A1R3XVB7	No	intermediary metabolism and respiration			A0A1R3XVB7				IPR001041,IPR002888,IPR012675	Q7U253					Rv0374c		Rv0374c			
NC_002945.3	Mycobrowser_v4	CDS	457285	457836	.	-	0	Mb0387c	Mb0387c		POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE)	Mb0387c, -, len: 183 aa. Equivalent to Rv0380c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Possible RNA methyltransferase (EC 2.1.1.-), equivalent to CAC32002.1|AL583925 possible RNA methyltransferase from Mycobacterium leprae (182 aa). Also some similarity with others methyltransferases e.g. P19396|TRMH_ECOLI|78514|JV0043 TRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa overlap). Also similar to Rv0881, Rv3579c, Rv1644 from Mycobacterium tuberculosis.	Q7U247,A0A1R3XV61	No	intermediary metabolism and respiration			A0A1R3XV61				IPR001537	Q7U247					Rv0380c		Rv0380c			
NC_002945.3	Mycobrowser_v4	CDS	453311	454171	.	-	0	Mb0382c	Mb0382c		PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM CHAIN)	Mb0382c, -, len: 286 aa. Equivalent to Rv0375c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable carbon monoxide dehydrogenase, medium chain (EC 1.2.99.2),similar to others e.g. AAD00361.1|U80806|CUTM carbon monoxide dehydrogenase middle subunit from Hydrogenophaga pseudoflava (287 aa); S49122|509389|CAA54900.1|X77931|CUTB carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (287 aa); A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (288 aa),FASTA scores: opt: 594, E(): 0, (37.5% identity in 277 aa overlap); etc.	Q7U252,A0A1R3XVP3	No	intermediary metabolism and respiration			A0A1R3XVP3				IPR002346,IPR005107,IPR016166,IPR016167,IPR016169	Q7U252					Rv0375c		Rv0375c			
NC_002945.3	Mycobrowser_v4	CDS	454247	455389	.	-	0	Mb0383c	Mb0383c		CONSERVED HYPOTHETICAL PROTEIN	Mb0383c, -, len: 380 aa. Equivalent to Rv0376c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 380 aa overlap). Conserved hypothetical protein, highly similar to T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical protein from Streptomyces coelicolor (395 aa); and AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from Arthrobacter nicotinovorans (377 aa). And similar to other conserved hypothetical proteins e.g. NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical protein from Mesorhizobium loti (245 aa). Note that C-terminus shows similarity with C-termini of CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); CAB76250.1|X82447|COXI CoxI protein from Pseudomonas/Oligotropha carboxidovorans (330 aa); and AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in 138 aa overlap). Also some partial similarity with AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3% identity in 92 aa overlap); E1184330|Z99120|YURF YURF PROTEIN from Bacillus subtilis (330 aa), FASTA scores: opt: 170, E(): 2.9e- 16, (27.5% identity in 345 aa overlap). Also similar to downstream ORF Rv0372c from Mycobacterium tuberculosis (251 aa), FASTA scores: E(): 2.1e-06, (30.7% identity in 277 aa overlap).	Q7U251,A0A1R3XV56	No	conserved hypotheticals			A0A1R3XV56				IPR003777,IPR027051	Q7U251					Rv0376c		Rv0376c			
NC_002945.3	Mycobrowser_v4	CDS	455438	456403	.	+	0	Mb0384	Mb0384		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LYSR-FAMILY)	Mb0384, -, len: 321 aa. Equivalent to Rv0377, len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 321 aa overlap). Probable transcription regulator, lysR family, showing similarity with many hypothetical transcriptional regulators lysR homolog e.g. P32484|YEIE_ECOLI|M89774 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli (293 aa), FASTA scores: opt: 265, E(): 4.9e-11, (28.6% identity in 266 aa overlap). Also similar to Rv2282c from Mycobacterium tuberculosis. Contains PS00044 bacterial regulatory protein lysR family signature. SEEMS TO BELONG TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7U250,A0A1R3XV57	No	regulatory proteins			A0A1R3XV57				IPR000847,IPR005119,IPR011991	Q7U250					Rv0377		Rv0377			
NC_002945.3	Mycobrowser_v4	CDS	456654	456875	.	+	0	Mb0385	Mb0385		CONSERVED HYPOTHETICAL GLYCINE RICH PROTEIN	Mb0385, -, len: 73 aa. Equivalent to Rv0378, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical gly-rich protein, showing some similarity to M. tuberculosis PE_PGRS family; also similar to MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD protein (1011 aa), FASTA scores: opt: 237, E(): 0.0032,(58.7% identity in 63 aa overlap); MTV043_25.	Q7U249,A0A1R3XV51	No	conserved hypotheticals			A0A1R3XV51					Q7U249					Rv0378		Rv0378			
NC_002945.3	Mycobrowser_v4	CDS	519752	520060	.	+	0	Mb0438	Mb0438		CONSERVED HYPOTHETICAL PROTEIN	Mb0438, -, len: 102 aa. Equivalent to Rv0430, len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, equivalent to AC30882.1|AL583923 conserved hypothetical protein from Mycobacterium leprae (102 aa). Also highly similar to CAB93047.1|SCD95A.20|AL357432 hypothetical protein from Streptomyces coelicolor (84 aa).	Q7U205,A0A1R3XXH1	No	conserved hypotheticals			A0A1R3XXH1				IPR021678	Q7U205					Rv0430		Rv0430			
NC_002945.3	Mycobrowser_v4	CDS	459478	460332	.	-	0	Mb0390c	Mb0390c		POSSIBLE CONSERVED SECRETED PROTEIN	Mb0390c, -, len: 284 aa. Equivalent to Rv0383c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Possible conserved secreted protein, with hydrophobic stretch in N-terminus and Pro-rich C-terminus. Equivalent to CAC32006.1|AL583925 possible secreted protein from Mycobacterium leprae (286 aa).	Q7U245,A0A1R3XWA4	No	cell wall and cell processes			A0A1R3XWA4					Q7U245					Rv0383c		Rv0383c			
NC_002945.3	Mycobrowser_v4	CDS	463152	464324	.	+	0	Mb0392	Mb0392		PROBABLE MONOOXYGENASE	Mb0392, -, len: 390 aa. Equivalent to Rv0385, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Probable monooxygenase (EC 1.-.-.-), similar to T37003|5738846|CAB52917.1|AL109949 probable flavohemoprotein from Streptomyces coelicolor (435 aa); and similar in part (C-termini) to various monooxygenases e.g. P19734|DMPP_PSESP|94993|F37831 PHENOL HYDROXYLASE P5 PROTEIN (PHENOL 2-MONOOXYGENASE P5 COMPONENT) (EC 1.14.13.7) from Pseudomonas putida (353 aa), FASTA scores: opt: 363, E(): 4.2e-16, (31.8% identity in 255 aa overlap); S47292|2120861|pir|S70085 phenol 2-monooxygenase (EC 1.14.13.7) chain mopP from Acinetobacter calcoaceticus (350 aa); P21394|XYLA_PSEPU|94933|B37316 XYLENE MONOOXYGENASE ELECTRON TRANSFER COMPONENT (EC 1.18.1.3) [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE] from Pseudomonas putida plasmid pWW0 (350 aa); AAC38360.1|AF043544|NtnMA|ntnA reductase component of 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 aa); etc.	Q7U244,A0A1R3XVR6	No	intermediary metabolism and respiration			A0A1R3XVR6				IPR000971,IPR001221,IPR001433,IPR001709,IPR008333,IPR009050,IPR012292,IPR017927,IPR017938	Q7U244					Rv0385		Rv0385			
NC_002945.3	Mycobrowser_v4	CDS	2265527	2266015	.	+	0	Mb2061	Mb2061		CONSERVED HYPOTHETICAL PROTEIN	Mb2061, -, len: 162 aa. Equivalent to Rv2035, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical protein (156 aa) from Sinorhizobium meliloti CAC46569.1|AL591789 (34% identity in 146 aa overlap).	Q7TZ39,A0A1R3XZZ7	No	conserved hypotheticals			A0A1R3XZZ7				IPR013538,IPR023393	Q7TZ39					Rv2035		Rv2035			
NC_002945.3	Mycobrowser_v4	CDS	473800	475125	.	+	0	Mb0399	Mb0399		CONSERVED 13E12 REPEAT FAMILY PROTEIN	Mb0399, -, len: 441. Equivalent to Rv0393, len: 441 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 441 aa overlap). Member of Mycobacterium tuberculosis 13E12 repeat family of conserved proteins,similar to many e.g. Rv1148c, Rv1945, Rv3467,Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0, (61.1% identity in 347 aa overlap).	Q7U237,A0A1R3XXD1	No	insertion seqs and phages			A0A1R3XXD1				IPR003615,IPR003870	Q7U237					Rv0393		Rv0393			
NC_002945.3	Mycobrowser_v4	CDS	475141	475860	.	-	0	Mb0400c	Mb0400c		POSSIBLE SECRETED PROTEIN	Mb0400c, -, len: 239 aa. Equivalent to Rv0394c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible secreted protein, sharing no homology with other proteins. Has hydrophobic stretch at its N-terminus.	Q7U236,A0A1R3XWB5	No	cell wall and cell processes			A0A1R3XWB5					Q7U236					Rv0394c		Rv0394c			
NC_002945.3	Mycobrowser_v4	CDS	475959	476363	.	+	0	Mb0401	Mb0401		HYPOTHETICAL PROTEIN	Mb0401, -, len: 134 aa. Equivalent to Rv0395, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Hypothetical unknown protein.	Q7U235,A0A1R3XVE0	No	conserved hypotheticals			A0A1R3XVE0					Q7U235					Rv0395		Rv0395			
NC_002945.3	Mycobrowser_v4	CDS	476369	476761	.	+	0	Mb0402	Mb0402		HYPOTHETICAL PROTEIN	Mb0402, -, len: 130 aa. Equivalent to Rv0396, len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Hypothetical unknown protein.	Q7U234,A0A1R3XVS6	No	conserved hypotheticals			A0A1R3XVS6					Q7U234					Rv0396		Rv0396			
NC_002945.3	Mycobrowser_v4	CDS	476835	477203	.	+	0	Mb0403	Mb0403		CONSERVED 13E12 REPEAT FAMILY PROTEIN	Mb0403, -, len: 122 aa. Equivalent to Rv0397, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Part of 13E12 repeat family of conserved Mycobacterium tuberculosis proteins,similar to downstream Rv0393|Z84725|MTCY4D9_5 CONSERVED 13E12 REPEAT FAMILY PROTEIN (441 aa), FASTA scores: E(): 0, (87.7% identity in 122 aa overlap).	Q7U233,A0A1R3XV65	No	insertion seqs and phages			A0A1R3XV65					Q7U233					Rv0397		Rv0397			
NC_002945.3	Mycobrowser_v4	CDS	499319	500638	.	-	0	Mb0420c	Mb0420c		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb0420c, -, len: 439 aa. Equivalent to Rv0412c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Possible conserved membrane protein, equivalent to AL035159|MLCB1450_16|T44737 probable membrane protein from Mycobacterium leprae (403 aa), FASTA scores: opt: 2027,E(): 0, (80.4% identity in 403 aa overlap). Also some similarity with CAB71201.1|AL138538 putative secreted protein from Streptomyces coelicolor (429 aa).	Q7U219,A0A1R3XVG1	No	cell wall and cell processes			A0A1R3XVG1					Q7U219					Rv0412c		Rv0412c			
NC_002945.3	Mycobrowser_v4	CDS	490906	491724	.	-	0	Mb0414c	Mb0414c		BETA LACTAMASE LIKE PROTEIN	Mb0414c, -, len: 272 aa. Equivalent to Rv0406c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Beta-lactamase-like protein, equivalent to AAD38170.1|AF152397_1 beta-lactamase-like protein from Mycobacterium phlei (243 aa); AL023514|MLCB4_8 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1284,E(): 0, (74.9% identity in 243 aa overlap); and AAD38164.1|AF152394_2 beta-lactamase-like protein from Mycobacterium avium (247 aa), FASTA scores: opt: 1301,E(): 0, (74.2% identity in 244 aa overlap); etc. Also slight similarity to others beta-lactamases and hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349 METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa),FASTA scores: (34.4% identity in 96 aa overlap).	Q7U223,A0A1R3XV84	No	conserved hypotheticals			A0A1R3XV84				IPR001279	Q7U223					Rv0406c		Rv0406c			
NC_002945.3	Mycobrowser_v4	CDS	521343	522473	.	+	0	Mb0441	Mb0441		CONSERVED HYPOTHETICAL PROTEIN	Mb0441, -, len: 376 aa. Equivalent to Rv0433, len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. P77213|YBDK_ECOLI hypothetical 41.7 KD protein from Escherichia coli strain K12 (372 aa), FASTA scores: opt: 555, E(): 2e-30, (28.2% identity in 365 aa overlap).	X2BF10,P64694,P64694	No	conserved hypotheticals			P64694					X2BF10,P64694					Rv0433		Rv0433			
NC_002945.3	Mycobrowser_v4	CDS	507580	507990	.	-	0	Mb0428c	Mb0428c		POSSIBLE TRANSMEMBRANE PROTEIN	Mb0428c, -, len: 136 aa. Equivalent to Rv0420c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 136 aa overlap). Possible transmembrane protein; has potential transmembrane domains aa 53-99 and aa 100-122.	Q7U213,A0A1R3XXG2	No	cell wall and cell processes			A0A1R3XXG2					Q7U213					Rv0420c		Rv0420c			
NC_002945.3	Mycobrowser_v4	CDS	508151	508780	.	-	0	Mb0429c	Mb0429c		CONSERVED HYPOTHETICAL PROTEIN	Mb0429c, -, len: 209 aa. Equivalent to Rv0421c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Conserved hypothetical protein, showing similarity with NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical protein from Mesorhizobium loti (214 aa).	Q7U212,A0A1R3XWD2	No	conserved hypotheticals			A0A1R3XWD2				IPR026555	Q7U212					Rv0421c		Rv0421c			
NC_002945.3	Mycobrowser_v4	CDS	617996	618646	.	+	0	Mb0539	Mb0539		POSSIBLE THIOREDOXIN PROTEIN (THIOL-DISULFIDE INTERCHANGE PROTEIN)	Mb0539, -, len: 216 aa. Equivalent to Rv0526, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Possible thioredoxin protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q49816|U2168C|S72901 hypothetical protein from Mycobacterium leprae (216 aa), FASTA scores: opt: 1144, E(): 0, (78.5% identity in 214 aa overlap). C-terminus shows some similarity to C-terminus of thioredoxins e.g. RESA_BACSU|P35160 resa protein from Bacillus subtilis (181 aa), FASTA scores: opt: 200, E(): 7.4e-06, (24.2% identity in 132 aa overlap); etc. Also similar to Mycobacterium tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194 Thioredoxin family active site. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY.	Q7U1U8,A0A1R3XVQ0	No	intermediary metabolism and respiration			A0A1R3XVQ0				IPR000866,IPR012336,IPR017937	Q7U1U8					Rv0526		Rv0526			
NC_002945.3	Mycobrowser_v4	CDS	511396	511671	.	-	0	Mb0432c	Mb0432c		HYPOTHETICAL PROTEIN	Mb0432c, -, len: 91 aa. Equivalent to Rv0424c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Hypothetical unknown protein.	Q7U211,A0A1R3XVA8	No	conserved hypotheticals			A0A1R3XVA8					Q7U211					Rv0424c		Rv0424c			
NC_002945.3	Mycobrowser_v4	CDS	516392	516835	.	-	0	Mb0434c	Mb0434c		POSSIBLE TRANSMEMBRANE PROTEIN	Mb0434c, -, len: 147 aa. Equivalent to Rv0426c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Possible transmembrane protein; has potential transmembrane domains aa 19-41, and aa 61-83.	Q7U209,A0A1R3XVA4	No	cell wall and cell processes			A0A1R3XVA4					Q7U209					Rv0426c		Rv0426c			
NC_002945.3	Mycobrowser_v4	CDS	517914	518822	.	-	0	Mb0436c	Mb0436c		gcn5-related n-acetyltransferase	Mb0436c, -, len: 302 aa. Equivalent to Rv0428c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Hypothetical unknown protein.	Q7U207,A0A1R3XVB0	No	intermediary metabolism and respiration			A0A1R3XVB0					Q7U207					Rv0428c		Rv0428c			
NC_002945.3	Mycobrowser_v4	CDS	623479	623796	.	+	0	Mb0544	Mb0544		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb0544, -, len: 105 aa. Equivalent to Rv0531, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Possible conserved membrane protein, highly similar to Y13803|MLB1306_1|CAA74131.1 hypothetical protein from Mycobacterium leprae (86 aa), FASTA scores: E(): 2.1e-24,(74.4% identity in 86 aa overlap); and NP_302557.1|NC_002677 putative membrane protein from Mycobacterium leprae (111 aa).	Q7U1U3,A0A1R3XVM1	No	cell wall and cell processes			A0A1R3XVM1				IPR025323	Q7U1U3					Rv0531		Rv0531			
NC_002945.3	Mycobrowser_v4	CDS	533415	533930	.	+	0	Mb0451	Mb0451		conserved protein	Mb0451, -, len: 171 aa. Equivalent to Rv0443, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Conserved hypothetical protein, highly similar to AL049863|SC5H1_23|T35339 hypothetical protein from Streptomyces coelicolor (171 aa), FASTA scores: opt: 561,E(): 2.3e-32, (49.7% identity in 165 aa overlap); and CAC42482.1|AJ318385 hypothetical protein from Amycolatopsis mediterranei (163 aa).	Q7U1Z8,A0A1R3XVX1	No	conserved hypotheticals			A0A1R3XVX1				IPR007061,IPR027369	Q7U1Z8					Rv0443		Rv0443			
NC_002945.3	Mycobrowser_v4	CDS	522533	523186	.	+	0	Mb0442	Mb0442		CONSERVED HYPOTHETICAL PROTEIN	Mb0442, -, len: 217 aa. Equivalent to Rv0434, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Conserved hypothetical protein, similar to AE002052_2 from Deinococcus radiodurans (213 aa), FASTA scores: opt: 258, E(): 4e-10,(31.9% identity in 213 aa overlap); SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from Synechocystis (214 aa),FASTA scores: opt: 156, E(): 0.00041, (28.4% identity in 204 aa overlap); MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2 from Myxococcus xanthus (826 aa), FASTA scores: opt: 160, E(): 0.00068, (28.4% identity in 197 aa overlap); etc.	Q7U203,A0A1R3XVC1	No	conserved hypotheticals			A0A1R3XVC1				IPR003111,IPR015947,IPR027065	Q7U203					Rv0434		Rv0434			
NC_002945.3	Mycobrowser_v4	CDS	1243004	1243327	.	+	0	Mb1148	Mb1148		conserved protein	Mb1148, -, len: 107 aa. Equivalent to Rv1117, len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 107 aa overlap). Conserved hypothetical protein, some similarity to P94425|D50453 hypothetical protein from Bacillus subtilis (95 aa), fasta scores: opt: 128, E(): 5.1e-06, (28.3% identity in 92 aa overlap); and AL117322|SCF1.02 Streptomyces coelicolor (109 aa), FASTA scores: opt: 437, E(): 1.6e-25, (57.5% identity in 106 aa overlap).	Q7U0M0,A0A1R3XXE3	No	conserved hypotheticals			A0A1R3XXE3				IPR007138,IPR011008	Q7U0M0					Rv1117		Rv1117			
NC_002945.3	Mycobrowser_v4	CDS	523366	525552	.	-	0	Mb0443c	Mb0443c		PUTATIVE CONSERVED ATPASE	Mb0443c, -, len: 728 aa. Equivalent to Rv0435c,len: 728 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 728 aa overlap). Putative conserved ATPase (EC 3.6.1.-), similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, E(): 0, (34.5% identity in 693 aa overlap); NP_148637.1|7435761|B72479 transitional endoplasmic reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also similar to Rv3610c and Rv2115c from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature.	Q7U202,A0A1R3XVC5	No	cell wall and cell processes			A0A1R3XVC5				IPR003338,IPR003593,IPR003959,IPR003960,IPR009010,IPR027417	Q7U202					Rv0435c		Rv0435c			
NC_002945.3	Mycobrowser_v4	CDS	528398	529333	.	-	0	Mb0447c	Mb0447c		probable dehydrogenase/reductase	Mb0447c, -, len: 311 aa. Equivalent to Rv0439c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Probable dehydrogenase/reductase (EC 1.-.-.-), equivalent to AL035159|MLCB1450_6|T44727 probable oxidoreductase from Mycobacterium leprae (304 aa), FASTA scores: opt: 1360,E(): 0, (69.2% identity in 302 aa overlap). Also highly similar to various oxidoreductases, generally dehydrogenases/reductases e.g. PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 probable short chain dehydrogenase from Pseudomonas aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE OXIDOREDUCTASE from Streptomyces antibioticus (298 aa),FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in 298 aa overlap); etc.	Q7U200,A0A1R3XVC2	No	intermediary metabolism and respiration			A0A1R3XVC2				IPR002198,IPR002347,IPR016040	Q7U200					Rv0439c		Rv0439c			
NC_002945.3	Mycobrowser_v4	CDS	531315	531743	.	-	0	Mb0449c	Mb0449c		HYPOTHETICAL PROTEIN	Mb0449c, -, len: 142 aa. Equivalent to Rv0441c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Hypothetical unknown protein.	X2BEY3,P0A5C8,P0A5C8	No	conserved hypotheticals			P0A5C8					X2BEY3,P0A5C8					Rv0441c		Rv0441c			
NC_002945.3	Mycobrowser_v4	CDS	535464	536234	.	-	0	Mb0454c	Mb0454c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0454c, -, len: 256 aa. Equivalent to Rv0446c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible conserved transmembrane protein, similar at N-terminus to U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3 from Streptomyces coelicolor (226 aa), FASTA scores: opt: 207, E(): 9.8e-07, (34.2% identity in 114 aa overlap). Also similar to others hypothetical proteins e.g. AAK04680.1|AE006291_14|AE006291) HYPOTHETICAL PROTEIN from Lactococcus lactis subsp. lactis (257 aa).	Q7U1Z5,A0A1R3XVC7	No	cell wall and cell processes			A0A1R3XVC7				IPR001104,IPR010721	Q7U1Z5					Rv0446c		Rv0446c			
NC_002945.3	Mycobrowser_v4	CDS	636817	637119	.	-	0	Mb0557c	Mb0557c		conserved protein	Mb0557c, -, len: 100 aa. Equivalent to Rv0543c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Conserved hypothetical protein, equivalent to Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 493, E(): 6.1e-30, (73.5% identity in 98 aa overlap). Some similarity to Rv3046c|NP_217562.1 from Mycobacterium tuberculosis.	Q7U1T4,A0A1R3XWP5	No	conserved hypotheticals			A0A1R3XWP5				IPR021784	Q7U1T4					Rv0543c		Rv0543c			
NC_002945.3	Mycobrowser_v4	CDS	537523	538188	.	-	0	Mb0456c	Mb0456c		CONSERVED HYPOTHETICAL PROTEIN	Mb0456c, -, len: 221 aa. Equivalent to Rv0448c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa),FASTA scores: opt: 257, E(): 1.4e-10, (32.0% identity in 197 aa overlap); etc. Some similarity to U15183|MLU15183_38 from Mycobacterium leprae (82 aa),FASTA scores: opt: 134, E(): 0.014, (71.0% identity in 31 aa overlap).	Q7U1Z3,A0A1R3XVC4	No	conserved hypotheticals			A0A1R3XVC4				IPR010775	Q7U1Z3					Rv0448c		Rv0448c			
NC_002945.3	Mycobrowser_v4	CDS	555035	555328	.	+	0	Mb0472	Mb0472		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0472, -, len: 97 aa. Equivalent to Rv0463, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Probable conserved transmembrane protein, highly similar to AAA63017.1|U15183 hypothetical protein from Mycobacterium leprae (101 aa),FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in 95 aa overlap).	Q7U1Y0,A0A1R3XVH1	No	cell wall and cell processes			A0A1R3XVH1					Q7U1Y0					Rv0463		Rv0463			
NC_002945.3	Mycobrowser_v4	CDS	1243342	1244202	.	-	0	Mb1149c	Mb1149c		conserved protein	Mb1149c, -, len: 286 aa. Equivalent to Rv1118c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 286 aa overlap). Conserved hypothetical protein, similar to pseudogene ML0942 in Mycobacterium leprae.	Q7TVC0,A0A1R3XXF8	No	conserved hypotheticals			A0A1R3XXF8					Q7TVC0					Rv1118c		Rv1118c			
NC_002945.3	Mycobrowser_v4	CDS	538248	539567	.	-	0	Mb0457c	Mb0457c		CONSERVED HYPOTHETICAL PROTEIN	Mb0457c, -, len: 439 aa. Equivalent to Rv0449c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 439 aa overlap). Conserved hypothetical protein, some similarity with several hypothetical proteins and various enzymes e.g. AAK24569.1|AE005927 amine oxidase, flavin-containing from Caulobacter crescentus (454 aa); BAB02771.1|AB023036 mycolic acid methyl transferase-like protein from Arabidopsis thaliana (842 aa); BAB01742.1|AP000374 protein which contains similarity to cyclopropane fatty acid synthase from Arabidopsis thaliana (793 aa); etc. Has hydrophobic stretch at N-terminus.	Q7U1Z2,A0A1R3XVD3	No	conserved hypotheticals			A0A1R3XVD3				IPR002937	Q7U1Z2					Rv0449c		Rv0449c			
NC_002945.3	Mycobrowser_v4	CDS	543161	543871	.	+	0	Mb0460	Mb0460		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0460, -, len: 236 aa. Equivalent to Rv0452, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Possible transcriptional regulator, similar to several putative TetR-family transcriptional regulators from Streptomyces coelicolor. Also similar in N-terminus to U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 aa), FASTA score: (76.1% identity in 67 aa overlap). Contains probable helix-turn-helix motif at aa 44-65 (Score 1727, +5.07 SD).	Q7U1Z0,A0A1R3XVI3	No	regulatory proteins			A0A1R3XVI3				IPR001647,IPR009057,IPR015893	Q7U1Z0					Rv0452		Rv0452			
NC_002945.3	Mycobrowser_v4	CDS	548605	550635	.	-	0	Mb0466c	Mb0466c		PROBABLE PEPTIDASE	Mb0466c, -, len: 676 aa. Equivalent to Rv0457c,len: 673 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 673 aa overlap). Probable peptidase (EC 3.4.-.-), similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable peptidase (EC 3.4.21.-) (726 aa), FASTA scores: opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8% identity in 299 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa).	Q7U1Y4,A0A1R3XVE9	No	intermediary metabolism and respiration			A0A1R3XVE9				IPR001375,IPR002470,IPR023302	Q7U1Y4					Rv0457c		Rv0457c			
NC_002945.3	Mycobrowser_v4	CDS	550694	552217	.	+	0	Mb0467	Mb0467		PROBABLE ALDEHYDE DEHYDROGENASE	Mb0467, -, len: 507 aa. Equivalent to Rv0458, len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 507 aa overlap). Probable aldehyde dehydrogenase (EC 1.2.1.3), highly similar to many,closest to P46369|THCA_RHOER EPTC-INDUCIBLE ALDEHYDE DEHYDROGENASE from Rhodococcus erythropolis (506 aa),FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa),FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO PROBABLE ALDEHYDE DEHYDROGENASE from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in M. tuberculosis e.g. Rv0768, Rv2858c. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.	X2BF41,P63938,P63938	No	intermediary metabolism and respiration			P63938					X2BF41,P63938					Rv0458		Rv0458			
NC_002945.3	Mycobrowser_v4	CDS	552217	552708	.	+	0	Mb0468	Mb0468		CONSERVED HYPOTHETICAL PROTEIN	Mb0468, -, len: 163 aa. Equivalent to Rv0459, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins. Note that highly similar to products of unidentified orfs in Xanthobacter autotrophicus,AF029733_2 (139 aa), and Rhodococcus erythropolis, REREUTP BC_1 (186 aa). Like MTV038.03, these ORF's are linked to aldehyde dehydrogenase genes. FASTA scores: AF0297|AF029733_2 (139 aa), opt: 439, E(): 6.2e-24, (50.0% identity in 126 aa overlap); and L24492|REREUTPBC_1 (186 aa), opt: 347, E(): 2.1e-17, (52.7% identity in 169 aa overlap). N-terminus also highly similar to AAA63041.1|U15183 ethanolamine permease (eutP) match from Mycobacterium leprae (53 aa).	Q7U1Y3,A0A1R3XWG3	No	conserved hypotheticals			A0A1R3XWG3				IPR008497	Q7U1Y3					Rv0459		Rv0459			
NC_002945.3	Mycobrowser_v4	CDS	552768	553007	.	+	0	Mb0469	Mb0469		CONSERVED HYDROPHOBIC PROTEIN	Mb0469, -, len: 79 aa. Equivalent to Rv0460, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 79 aa overlap). Conserved hydrophobic protein, highly similar AAA63024.1|U15183 hypothetical protein from Mycobacterium leprae (56 aa), FASTA scores: opt: 197, E(): 3.7e-09, (63.8% identity in 47 aa overlap).	Q7U1Y2,A0A1R3XVJ3	No	conserved hypotheticals			A0A1R3XVJ3					Q7U1Y2					Rv0460		Rv0460			
NC_002945.3	Mycobrowser_v4	CDS	553045	553569	.	+	0	Mb0470	Mb0470		PROBABLE TRANSMEMBRANE PROTEIN	Mb0470, -, len: 174 aa. Equivalent to Rv0461, len: 174 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 174 aa overlap). Probable transmembrane protein.	Q7U1Y1,A0A1R3XVY8	No	cell wall and cell processes			A0A1R3XVY8					Q7U1Y1					Rv0461		Rv0461			
NC_002945.3	Mycobrowser_v4	CDS	555901	557325	.	-	0	Mb0474c	Mb0474c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0474c, -, len: 474 aa. Equivalent to Rv0465c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 474 aa overlap). Probable transcriptional regulator, highly similar to AC44331.1|AL596102 putative DNA-binding protein from Streptomyces coelicolor (489 aa); and similar to several hypothetical proteins and others transcriptional regulators. Some similarity in N-terminal region (1-100 aa) with repressors e.g. P06153|RPC_BPPH1 IMMUNITY REPRESSOR PROTEIN (144 aa), FASTA scores: opt: 130, E(): 0.084,(27.0% identity in 100 aa overlap). Very similar to Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium tuberculosis (486 aa), FASTA scores: opt: 1475, E(): 0,(47.4% identity in 468 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (1827, +5.41 SD).	Q7U1X8,A0A1R3XVD8	No	regulatory proteins			A0A1R3XVD8				IPR001387,IPR010359,IPR010982,IPR018653,IPR026281	Q7U1X8					Rv0465c		Rv0465c			
NC_002945.3	Mycobrowser_v4	CDS	557477	558271	.	+	0	Mb0475	Mb0475		conserved protein	Mb0475, -, len: 264 aa. Equivalent to Rv0466, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Conserved hypothetical protein, equivalent to CAC31980.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (264 aa). Similar to Rv2001|Z74025|MTCY39.17c HYPOTHETICAL 28.7 KDA PROTEIN from Mycobacterium tuberculosis (250 aa),FASTA scores: opt: 592, E(): 0, (38.0% identity in 263 aa overlap). Some similarity to several THIOESTERASES e.g. Q42561|ATACPTE17_1 ACYL-(ACYL CARRIER PROTEIN) THIOESTER from A. thaliana (362 aa), FASTA scores: E(): 0.0092,(24.4% identity in 197 aa overlap).	Q7U1X7,A0A1R3XVD9	No	conserved hypotheticals			A0A1R3XVD9				IPR002864	Q7U1X7					Rv0466		Rv0466			
NC_002945.3	Mycobrowser_v4	CDS	563742	564446	.	-	0	Mb0482c	Mb0482c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)	Mb0482c, -, len: 234 aa. Equivalent to Rv0472c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable regulatory protein, possibly tetR family, equivalent to CAC31974.1|AL583925 possible TetR-family transcriptional regulator from Mycobacterium leprae (233 aa). Also similar to CAC01492.1|AL391017 putative transcriptional regulatory protein from Streptomyces coelicolor (218 aa); and CAC01371.1|AL390975 putative tetR-family transcriptional regulator from Streptomyces coelicolor (228 aa). Also similar to AL0212|MTV012_65 from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 327, E(): 1.8e-15, (31.0% identity in 232 aa overlap); and Z95120|MTCY07D11.18c (228 aa), FASTA scores: opt: 190,E(): 4.4e-06, (23.1% identity in 186 aa overlap). Contains probable helix-turn-helix doimain at aa 45-66 (Score 1429,+4.05 SD).	Q7U1X1,A0A1R3XVI6	No	regulatory proteins			A0A1R3XVI6				IPR001647,IPR009057,IPR011075,IPR015893	Q7U1X1					Rv0472c		Rv0472c			
NC_002945.3	Mycobrowser_v4	CDS	564583	565953	.	+	0	Mb0483	Mb0483		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0483, -, len: 456 aa. Equivalent to Rv0473, len: 456 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 456 aa overlap). Possible conserved transmembrane protein, showing some similarity to hypothetical proteins e.g. NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical protein from Mesorhizobium loti (431 aa); P39385|YJIN_ECOLI|YJIN|B4336 HYPOTHETICAL 48.2 KD PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain K12 (426 aa), FASTA scores: opt: 396, E(): 9.8e-19, (31.8 % identity in 424 aa overlap); etc.	Q7U1X0,A0A1R3XVH2	No	cell wall and cell processes			A0A1R3XVH2				IPR007383	Q7U1X0					Rv0473		Rv0473			
NC_002945.3	Mycobrowser_v4	CDS	566040	566462	.	+	0	Mb0484	Mb0484		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0484, -, len: 140 aa. Equivalent to Rv0474, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable transcriptional regulator, highly similar to others e.g. CAC04034.1|AL391406 putative DNA-binding protein from Streptomyces coelicolor (141 aa); N-terminus of NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional regulator from Mesorhizobium loti (219 aa); N-terminus of A83618|PA0225 probable transcription regulator from Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr protein from Bacillus subtilis (111 aa), FASTA scores: opt: 147, E(): 8.9e-06, (30.6% identity in 111 aa overlap). Also similar to other hypothetical proteins e.g. X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa),FASTA scores: opt: 280, E(): 4.8e-12, (43.6% identity in 117 aa overlap). Also similar to Rv2745c from Mycobacterium tuberculosis. Contains probable helix-turn-helix domain at aa 35-56 (Score 1709, +5.01 SD).	Q7U1W9,A0A1R3XVE3	No	regulatory proteins			A0A1R3XVE3				IPR001387,IPR010982	Q7U1W9					Rv0474		Rv0474			
NC_002945.3	Mycobrowser_v4	CDS	567527	567790	.	+	0	Mb0486	Mb0486		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0486, -, len: 87 aa. Equivalent to Rv0476, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Possible conserved transmembrane protein, equivalent to CAC31970.1|AL583925 conserved membrane protein from Mycobacterium leprae (95 aa). Also highly similar to CAC04036.1|AL391406 putative membrane protein from Streptomyces coelicolor (113 aa). Contains PS00606 Beta-ketoacyl synthases active site.	X2BF48,P64696,P64696	No	cell wall and cell processes			P64696					X2BF48,P64696					Rv0476		Rv0476			
NC_002945.3	Mycobrowser_v4	CDS	622057	623274	.	+	0	Mb0543	Mb0543		conserved protein	Mb0543, -, len: 405 aa. Equivalent to Rv0530, len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. AL031231|SC3C3_3|CAA20252.1 from Streptomyces coelicolor (1083 aa), FASTA scores: opt: 870, E(): 0, (39.5% identity in 443 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3868, Rv0282, Rv1798, etc.	Q7U1U4,A0A1R3XVM4	No	conserved hypotheticals			A0A1R3XVM4				IPR025669,IPR027417	Q7U1U4					Rv0530		Rv0530			
NC_002945.3	Mycobrowser_v4	CDS	568940	569986	.	-	0	Mb0489c	Mb0489c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb0489c, -, len: 348 aa. Equivalent to Rv0479c,len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 348 aa overlap). Probable conserved membrane protein, equivalent to CAC31967.1|AL583925 possible secreted protein from Mycobacterium leprae (254 aa); and C-terminus highly similar to AAF74996.1|AF143402_1|AF143402 putative multicopper oxidase from Mycobacterium avium (149 aa). Contains hydrophobic domain in centre of protein.	X2BF60,P64700,P64700	No	cell wall and cell processes			P64700					X2BF60,P64700					Rv0479c		Rv0479c			
NC_002945.3	Mycobrowser_v4	CDS	589476	590318	.	+	0	Mb0509	Mb0509		CONSERVED HYPOTHETICAL PROTEIN	Mb0509, -, len: 280 aa. Equivalent to Rv0498, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to P54581|Y498_MYCLE|ML2432 HYPOTHETICAL 30.5 KDA PROTEIN from Mycobacterium leprae (280 aa); and S72896|B2168_C2_210 hypothetical protein from Mycobacterium leprae (244 aa), FASTA scores: opt: 1486,E():0, (89.3% identity in 244 aa overlap). Also similar to Q9X8H0|Y714_STRCO|SCE7.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor.	X2BF84,P64718	No	conserved hypotheticals			P64718					X2BF84					Rv0498		Rv0498			
NC_002945.3	Mycobrowser_v4	CDS	569983	570918	.	-	0	Mb0490c	Mb0490c		possible amidohydrolase	Mb0490c, -, len: 311 aa. Equivalent to Rv0480c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Conserved hypothetical protein, equivalent, but longer 60 aa in N-terminus, to CAC31966.1|AL583925 putative hydrolase from Mycobacterium leprae (271 aa). Also similar to several hypothetical proteins and hydrolases e.g. AL096822|SCGD3_8 probable hydrolase from Streptomyces coelicolor (264 aa),FASTA scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa overlap); and YAUB_SCHPO|Q10166 hypothetical 35.7 kd protein c26a3.11 from S. pombe (322 aa), FASTA scores: opt: 338, E():1.4e-13, (30.3% identity in 277 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (329 aa versus 340 aa).	Q7U1W8,A0A1R3XW03	No	intermediary metabolism and respiration			A0A1R3XW03				IPR001110,IPR003010	Q7U1W8					Rv0480c		Rv0480c			
NC_002945.3	Mycobrowser_v4	CDS	574009	574764	.	-	0	Mb0494c	Mb0494c		probable short-chain type oxidoreductase	Mb0494c, -, len: 251 aa. Equivalent to Rv0484c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Probable short-chain oxidoreductase (EC 1.-.-.-), highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. STRONG SIMILARITY,TO BACTERIAL YDFG HOMOLOGS.	Q7U1W7,A0A1R3XVE6	No	intermediary metabolism and respiration			A0A1R3XVE6				IPR002198,IPR002347,IPR016040	Q7U1W7					Rv0484c		Rv0484c			
NC_002945.3	Mycobrowser_v4	CDS	666676	666843	.	-	0	Mb0587A	Mb0587A		HYPOTHETICAL PROTEIN	Mb0587A, -, len: 55 aa. Equivalent to Mt0407.1 from Mycobacterium tuberculosis strain CDC1551, (100% identity with 55 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb0587A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BFF4,UPI00000D2B7D	No				UPI00000D2B7D					X2BFF4										
NC_002945.3	Mycobrowser_v4	CDS	574947	576263	.	+	0	Mb0495	Mb0495		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0495, -, len: 438 aa. Equivalent to Rv0485, len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Possible transcriptional repressor, member of the NAGC/XYLR repressor FAMILY; similar to several e.g. D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor from Vibrio cholerae (404 aa), FASTA scores: opt: 378,E(): 1.2e-17, (26.9% identity in 350 aa overlap); NAGC_ECOLI|P15301 N-acetylglucosamine repressor from Escherichia coli (406 aa), FASTA scores: opt: 305, E(): 1.8e-12, (21.8% identity in 357 aa overlap); etc.	X2BF70,P64706	No	regulatory proteins			P64706					X2BF70					Rv0485		Rv0485			
NC_002945.3	Mycobrowser_v4	CDS	590334	591209	.	+	0	Mb0510	Mb0510		CONSERVED HYPOTHETICAL PROTEIN	Mb0510, -, len: 291 aa. Equivalent to Rv0499, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Conserved hypothetical protein, showing some similarity to AL031184|SC2A11_16|T34762 hypothetical protein from Streptomyces coelicolor (340 aa), FASTA scores: opt: 240,E(): 1.8e-07, (28.9% identity in 270 aa overlap).	X2BF78,P64720,P64720	No	conserved hypotheticals			P64720					X2BF78,P64720					Rv0499		Rv0499			
NC_002945.3	Mycobrowser_v4	CDS	577750	578301	.	+	0	Mb0497	Mb0497		CONSERVED HYPOTHETICAL PROTEIN	Mb0497, -, len: 183 aa. Equivalent to Rv0487, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, highly similar to P54139|Y487_MYCLE|U00018_38|ML2442 HYPOTHETICAL 20.8 KDA PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa overlap). Also highly similar to CAC04041.1|AL391406 conserved hypothetical protein from Streptomyces coelicolor (168 aa).	X2BF77,P64710	No	conserved hypotheticals			P64710					X2BF77					Rv0487		Rv0487			
NC_002945.3	Mycobrowser_v4	CDS	578685	579290	.	+	0	Mb0498	Mb0498		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0498, -, len: 201 aa. Equivalent to Rv0488, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to others and conserved hypothetical proteins e.g. AB93746.1|AL357613 putative membrane transport protein from Streptomyces coelicolor (204 aa); D83100|PA4365 probable transporter from Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667 hypothetical 21.7 kd protein from Escherichia coli (197 aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity in 179 aa overlap); CGLYSEG_2 C|P94633 LYSINE EXPORTER PROTEIN (236 aa), FASTA scores: E(): 2.3e-07, (33.3% identity in 219 aa overlap). Also similar to Rv1986 from Mycobacterium tuberculosis.	X2BF53,P64712,P64712	No	cell wall and cell processes			P64712					X2BF53,P64712					Rv0488		Rv0488			
NC_002945.3	Mycobrowser_v4	CDS	592262	592498	.	+	0	Mb0512	Mb0512		conserved protein	Mb0512, -, len: 78 aa. Equivalent to Rv0500A, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): 1.3e-27, (82.6% identity in 86 aa overlap); AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 identity in 54 aa overlap).	Q7U1W2,A0A1R3XVL7	No	conserved hypotheticals			A0A1R3XVL7				IPR009061,IPR010093	Q7U1W2					Rv0500A		Rv0500A			
NC_002945.3	Mycobrowser_v4	CDS	582640	584529	.	-	0	Mb0502c	Mb0502c		PROBABLE OXIDOREDUCTASE GMC-TYPE	Mb0502c, -, len: 629 aa. Equivalent to Rv0492c,len: 629 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 629 aa overlap). Probable oxidoreductase GMC type (EC 1.-.-.-), similar to others except in N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN HYPOTHETICAL GMC-TYPE OXIDOREDUCTASE from Rhizobium sp. (505 aa), FASTA scores: opt: 873, E():0, (34.3% identity in 502 aa overlap); YTH2_RHOER|P46371 HYPOTHETICAL 53.0 kd GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa), FASTA score: (25.7% identity in 521 aa overlap); YTH2_RHOSO|P46371 hypothetical 53.0 kd gmc-type oxidoreductase from Rhodococcus erythropolis (493 aa),FASTA score: (25.7% identity in 521 aa overlap); NP_085596.1|NC_002679 probable oxidoreductase from Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC oxidoreductase from Deinococcus radiodurans (722 aa); NP_249055.1|NC_002516 probable oxidoreductase from Pseudomonas aeruginosa (531 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD (BY SIMILARITY). Note that start changed since first submission (previously 684 aa).	Q7U1W6,A0A1R3XVL2	No	intermediary metabolism and respiration			A0A1R3XVL2				IPR000172,IPR007867	Q7U1W6					Rv0492c		Rv0492c			
NC_002945.3	Mycobrowser_v4	CDS	585846	586574	.	+	0	Mb0505	Mb0505		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY)	Mb0505, -, len: 242 aa. Equivalent to Rv0494, len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Probable transcriptional regulator, GntR family, with C-terminal part highly similar to S72893|B2168_C2_205 hypothetical protein from Mycobacterium leprae (105 aa). Also similar to other transcription regulators e.g. PDHR_ECOLI|P06957 pyruvate dehydrogenase complex repressor PDHR or GENA from Escherichia coli (254 aa), FASTA scores: opt: 284, E(): 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature, and probable helix-turn helix motif from aa 50-71 (Score 1229, +3.37 SD).	X2BF74,P67740,P67740	No	regulatory proteins			P67740					X2BF74,P67740					Rv0494		Rv0494			
NC_002945.3	Mycobrowser_v4	CDS	612322	613224	.	-	0	Mb0532c	Mb0532c		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb0532c, -, len: 300 aa. Equivalent to Rv0519c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Possible conserved membrane protein, with hydrophobic region near N-terminus. Could be a lipase (EC 3.1.-.-). Similar to Rv0774c|MTCY369.19c|A70708 from Mycobacterium tuberculosis (312 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00120 Lipases, serine active site.	Q7U1V4,A0A1R3XVN9	No	cell wall and cell processes			A0A1R3XVN9				IPR000801,IPR006311	Q7U1V4					Rv0519c		Rv0519c			
NC_002945.3	Mycobrowser_v4	CDS	586575	587465	.	-	0	Mb0506c	Mb0506c		CONSERVED HYPOTHETICAL PROTEIN	Mb0506c, -, len: 296 aa. Equivalent to Rv0495c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Conserved hypothetical protein, highly similar to S72915|B2168_F1_37 hypothetical protein from Mycobacterium leprae (323 aa),FASTA scores: opt: 1615, E(): 0, (82.7% identity in 271 aa overlap); and P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (271 aa).	X2BF95,P64714	No	conserved hypotheticals			P64714					X2BF95					Rv0495c		Rv0495c			
NC_002945.3	Mycobrowser_v4	CDS	587545	588531	.	+	0	Mb0507	Mb0507		CONSERVED HYPOTHETICAL PROTEIN	Mb0507, -, len: 328 aa. Equivalent to Rv0496, len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 328 aa overlap). Conserved hypothetical protein, highly similar to S72894|467046|AAA17230.1|U00018 exopolyphosphatase (EC 3.6.1.11) ppx from Mycobacterium leprae (406 aa), FASTA scores: opt: 1902, E(): 0, (86.6% identity in 343 aa overlap); and P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium leprae (339 aa). Also highly similar to hypothetical proteins and exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa). C-terminal region similar to CGU31224_1|Q46054 protein similar to ppx gene product of Mycobacterium leprae from Cornybacterium glutamicum (140 aa), FASTA scores: opt: 615, E(): 2.7e-33, (70.9% identity in 134 aa overlap).	X2BF85,P65787,P65787	No	conserved hypotheticals			P65787					X2BF85,P65787					Rv0496		Rv0496			
NC_002945.3	Mycobrowser_v4	CDS	588528	589460	.	+	0	Mb0508	Mb0508		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0508, -, len: 310 aa. Equivalent to Rv0497, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Probable conserved transmembrane protein, equivalent (but shorter in C-terminus) to P54580|Y497_MYCLE|ML2433 HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium leprae (355 aa). N-terminus highly similar to S72922|B2168_C1_166|467074 hypothetical protein from Mycobacterium leprae (118 aa), FASTA scores: opt: 350, E(): 1.4e-12, (57.9% identity in 114 aa overlap); and hydrophobic C-terminus, highly similar to S72895|B2168_C2_209|467047 hypothetical protein from Mycobacterium leprae (241 aa), FASTA scores: opt: 473,E(): 8e-19, (53.9% identity in 241 aa).	X2BF59,P64716,P64716	No	cell wall and cell processes			P64716					X2BF59,P64716					Rv0497		Rv0497			
NC_002945.3	Mycobrowser_v4	CDS	593942	595018	.	+	0	Mb0514	Mb0514		conserved protein	Mb0514, -, len: 358 aa. Equivalent to Rv0502, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Conserved hypothetical protein, equivalent to P54878|Y502_MYCLE|ML2427 HYPOTHETICAL 40.5 KDA PROTEIN from Mycobacterium leprae (367 aa), FASTA scores: opt: 2042, E(): 0, (84.1% identity in 365 aa overlap). Also similar to T36273|SCE68.23c hypothetical protein from Streptomyces coelicolor (355 aa). C-terminal similar to AL021529|SC10A5_4|T34572 hypothetical protein from Streptomyces coelicolor (295 aa), FASTA score: (57.8% identity in 263 aa overlap); and to hypothetical proteins from Mycobacterium tuberculosis Rv1920|G70808 (287 aa); and Rv1428c|G70914 (275 aa).	X2BF83,P64724,P64724	No	conserved hypotheticals			P64724					X2BF83,P64724					Rv0502		Rv0502			
NC_002945.3	Mycobrowser_v4	CDS	595953	596453	.	-	0	Mb0516c	Mb0516c		conserved protein	Mb0516c, -, len: 166 aa. Equivalent to Rv0504c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, equivalent to P54879|Y504_MYCLE|ML2425 HYPOTHETICAL 18.7 KDA PROTEIN from Mycobacterium leprae (166 aa), FASTA scores: opt: 884, E(): 0, (83.1% identity in 166 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). Also similar to M. tuberculosis hypothetical proteins Rv0635|H70612 (158 aa); and Rv0637|B70613 (166 aa).	X2BF94,P64726	No	conserved hypotheticals			P64726					X2BF94					Rv0504c		Rv0504c			
NC_002945.3	Mycobrowser_v4	CDS	613405	613755	.	+	0	Mb0533	Mb0533		POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT)	Mb0533, -, len: 116 aa. Equivalent to Rv0520, len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). Possible fragment of methyltransferase (possibly first part) (EC 2.1.1.-),highly similar to part of several methyltransferases e.g. Q43445|U43683 S-ADENOSYL-L-METHIONINE:DELTA24-STEROL-C-METHYLTRANSFERASE from Glycine max (Soybean)(367 aa), FASTA scores: opt: 190, E(): 2.3e-12, (39.2% identity in 74 aa overlap). Also some similarity to MTCY19G5_5 from Mycobacterium tuberculosis. Possibly continues as Rv0521 but we can find no frameshift to account for this.	Q7U1V3,A0A1R3XVL4	No	intermediary metabolism and respiration			A0A1R3XVL4				IPR013216	Q7U1V3					Rv0520		Rv0520			
NC_002945.3	Mycobrowser_v4	CDS	601249	601542	.	+	0	Mb0520	Mb0520		CONSERVED HYPOTHETICAL PROTEIN	Mb0520, -, len: 97 aa. Equivalent to Rv0508, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, showing similarity with T36269|5123666|CAB45355.1|AL079345 probable redoxin from Streptomyces coelicolor (101 aa), FASTA scores: opt: 160,E(): 3.4e-05, (33.3% identity in 75 aa overlap); and E81943|NMA0966 probable thioredoxin from Neisseria meningitidis group A strain Z2491 (77 aa).	X2BFA6,P64728	No	conserved hypotheticals			P64728					X2BFA6					Rv0508		Rv0508			
NC_002945.3	Mycobrowser_v4	CDS	613748	614053	.	+	0	Mb0534	Mb0534		POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT)	Mb0534, -, len: 101 aa. Equivalent to Rv0521, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Possible fragment of methyltransferase (possibly second part) (EC 2.1.1.-),highly similar to C-terminus of several methyltransferases e.g. AAF87203.1|AF216282 sarcosine-dimethylglycine methyltransferase from Halorhodospira halochloris (279 aa). Possibly continuation of Rv0520 but we can find no frameshift to account for this.	Q7U1V2,A0A1R3XVL0	No	intermediary metabolism and respiration			A0A1R3XVL0				IPR023143	Q7U1V2					Rv0521		Rv0521			
NC_002945.3	Mycobrowser_v4	CDS	606755	607303	.	+	0	Mb0526	Mb0526		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0526, -, len: 182 aa. Equivalent to Rv0513, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Possible conserved transmembrane protein, with its N-terminus highly similar to S72925|B2168_C1_182 hypothetical protein from Mycobacterium leprae (103 aa), FASTA scores: opt: 217,E(): 8.2e-14, (45.3 % identity in 106 aa overlap).	Q7U1V9,A0A1R3XVK9	No	cell wall and cell processes			A0A1R3XVK9				IPR016844	Q7U1V9					Rv0513		Rv0513			
NC_002945.3	Mycobrowser_v4	CDS	607702	609213	.	+	0	Mb0528	Mb0528		CONSERVED 13E12 REPEAT FAMILY PROTEIN	Mb0528, -, len: 503 aa. Equivalent to Rv0515, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Part of M. tuberculosis 13E12 repeat family. Almost identical to Rv0336 (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other M. tuberculosis hypothetical 13E12 repeat proteins e.g. Rv1148c, Rv1945, etc.	Q7TTD9,A0A0G2QBY8	No	insertion seqs and phages			A0A0G2QBY8				IPR003615,IPR003870	Q7TTD9					Rv0515		Rv0515			
NC_002945.3	Mycobrowser_v4	CDS	609210	609686	.	-	0	Mb0529c	Mb0529c		possible anti-anti-sigma factor	Mb0529c, -, len: 158 aa. Equivalent to Rv0516c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, showing some similarity to Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 aa), FASTA scores: E(): 0.0012, (27.4% identity in 124 aa overlap).	Q7U1V7,A0A1R3XVP1	No	information pathways			A0A1R3XVP1				IPR002645	Q7U1V7					Rv0516c		Rv0516c			
NC_002945.3	Mycobrowser_v4	CDS	1371536	1372069	.	-	0	Mb1259c	Mb1259c		PROBABLE TRANSMEMBRANE PROTEIN	Mb1259c, -, len: 177 aa. Equivalent to Rv1227c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 177 aa overlap). Possible transmembrane protein, similar to P96615 hypothetical protein ydbS from Bacillus subtilis (159 aa), fasta scores: E(): 3.6e-07,(30.1% identity in 163 aa overlap).	Q7U0C4,A0A1R3XXQ6	No	cell wall and cell processes			A0A1R3XXQ6				IPR005182	Q7U0C4					Rv1227c		Rv1227c			
NC_002945.3	Mycobrowser_v4	CDS	649202	649717	.	+	0	Mb0571	Mb0571		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0571, -, len: 171 aa. Equivalent to Rv0556, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 171 aa overlap). Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa).	Q7U1S3,A0A1R3XVS5	No	cell wall and cell processes			A0A1R3XVS5					Q7U1S3					Rv0556		Rv0556			
NC_002945.3	Mycobrowser_v4	CDS	609897	611207	.	+	0	Mb0530	Mb0530		POSSIBLE MEMBRANE ACYLTRANSFERASE	Mb0530, -, len: 436 aa. Equivalent to Rv0517, len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 436 aa overlap). Possible acyltransferase (EC 2.3.1.-), integral membrane protein,equivalent (but longer 26 aa in N-terminus) to AAK44761.1|AE006954 putative acyltransferase from Mycobacterium tuberculosis strain CDC1551 (410 aa). Also similar to many acyltransferases e.g. MDMB_STRMY|Q00718 from Streptomyces mycarofaciens (387 aa), FASTA scores: opt: 200, E(): 1.1e-08, (28.2% identity in 394 aa overlap). And similar to Rv0111, Rv0228, Rv1254, Rv1565c from Mycobacterium tuberculosis.	Q7U1V6,A0A1R3XW43	No	intermediary metabolism and respiration			A0A1R3XW43				IPR002656	Q7U1V6					Rv0517		Rv0517			
NC_002945.3	Mycobrowser_v4	CDS	615476	615871	.	-	0	Mb0536c	Mb0536c		conserved protein	Mb0536c, -, len: 131 aa. Equivalent to Rv0523c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing some similarity to M. tuberculosis proteins Rv1598c|MTCY336.06; and Rv1871c|MTCY336_06|O06592 (136 aa), FASTA scores: opt: 197, E(): 5e-08, (38.4% identity in 99 aa overlap).	Q7U1V0,A0A1R3XVL6	No	conserved hypotheticals			A0A1R3XVL6				IPR004378	Q7U1V0					Rv0523c		Rv0523c			
NC_002945.3	Mycobrowser_v4	CDS	898911	899540	.	+	0	Mb0827	Mb0827		CONSERVED HYPOTHETICAL PROTEIN	Mb0827, -, len: 209 aa. Equivalent to Rv0804, len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Conserved hypothetical protein, showing similarity with C-terminus of Rv1863c|MTCY359.10 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 199, E(): 1.2e-05, (33.2% identity in 220 aa overlap); and Rv0658c. Contains PS01151 Fimbrial biogenesis outer membrane usher protein signature.	Q7U186,A0A1R3XWG8	No	conserved hypotheticals			A0A1R3XWG8				IPR003675,IPR015837	Q7U186					Rv0804		Rv0804			
NC_002945.3	Mycobrowser_v4	CDS	617373	617981	.	+	0	Mb0538	Mb0538		conserved protein	Mb0538, -, len: 202 aa. Equivalent to Rv0525, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein, equivalent to Q49821|B2168_C3_276|S72912 hypothetical protein from Mycobacterium leprae (202 aa), FASTA scores: opt: 1151,E(): 0, (82.5% identity in 200 aa overlap). Also highly similar to CAC08377.1|AL392176 putative phosphoglycerate mutase from Streptomyces coelicolor (233 aa); and similar to SLL0395|Q55734 hypothetical 23.8 kDa protein from SYNECHOCYSTIS SP. (212 aa), FASTA scores: opt: 207, E(): 5.1e-07, (28.2% identity in 195 aa overlap). Also some similarity to Rv2228c|Y019_MYCTU|Q10512|cy427.09 hypothetical 39.2 kd protein from Mycobacterium tuberculosis (364 aa), FASTA scores: opt: 236, E(): 1.1e-08, (34.3% identity in 198 aa overlap).	Q7U1U9,A0A1R3XWM5	No	conserved hypotheticals			A0A1R3XWM5				IPR013078	Q7U1U9					Rv0525		Rv0525			
NC_002945.3	Mycobrowser_v4	CDS	652022	652747	.	-	0	Mb0575c	Mb0575c		POSSIBLE BENZOQUINONE METHYLTRANSFERASE (METHYLASE)	Mb0575c, -, len: 241 aa. Equivalent to Rv0560c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Possible benzoquinone methyltransferase (EC 2.1.1.-) (see citation below),similar to other hypothetical proteins and methyltransferases e.g. Q54300 METHYLTRANSFERASE (211 aa),FASTA scores: opt: 203, E(): 4.8e-07, (30.9% identity in 136 aa overlap). Similar to Rv3699, Rv1377c, Rv2675c, etc from Mycobacterium tuberculosis. Rv0560c can be induced by salicylate and para-amino-salicylate (PAS).	Q7U1S0,A0A1R3XVP7	No	intermediary metabolism and respiration			A0A1R3XVP7				IPR025714	Q7U1S0					Rv0560c		Rv0560c			
NC_002945.3	Mycobrowser_v4	CDS	619455	621044	.	+	0	Mb0541	Mb0541		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0541, -, len: 529 aa. Equivalent to Rv0528, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 529 aa overlap). Probable conserved transmembrane protein, equivalent (shorter 14 aa in N-terminus) to CAC31926.1|AL583925 conserved membrane protein from Mycobacterium leprae (542 aa). Also highly similar to Q49817|B2168_C2_237|S72902 hypothetical protein from Mycobacterium leprae (364 aa), FASTA scores: opt: 1846, E(): 0, (81.1% identity in 338 aa overlap); and Q49811|B2168_C1_194|S72891 hypothetical protein from Mycobacterium leprae (106 aa), FASTA scores: opt: 506,E(): 3.8e-26, (73.6% identity in 106 aa overlap). Also highly similar to CAC08381.1|AL392176 putative integral membrane protein from Streptomyces coelicolor (574 aa).	Q7U1U6,A0A1R3XVK6	No	cell wall and cell processes			A0A1R3XVK6				IPR007816	Q7U1U6					Rv0528		Rv0528			
NC_002945.3	Mycobrowser_v4	CDS	1167501	1168124	.	+	0	Mb1073	Mb1073		CONSERVED HYPOTHETICAL PROTEIN	Mb1073, -, len: 207 aa. Equivalent to Rv1044, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 207 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap).	Q7U0T1,A0A1R3XZB5	No	conserved hypotheticals			A0A1R3XZB5				IPR025159	Q7U0T1					Rv1044		Rv1044			
NC_002945.3	Mycobrowser_v4	CDS	629542	630975	.	-	0	Mb0551c	Mb0551c		PROBABLE INTEGRAL MEMBRANE PROTEIN	Mb0551c, -, len: 477 aa. Equivalent to Rv0537c,len: 477 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 477 aa overlap). Probable integral membrane protein, showing weak similarity to YDNK_STRCO|P40180 hypothetical 41.2 kd protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 122,E(): 0.85, (28.2% identity in 373 aa overlap).	Q7U1T9,A0A1R3XVQ8	No	cell wall and cell processes			A0A1R3XVQ8					Q7U1T9					Rv0537c		Rv0537c			
NC_002945.3	Mycobrowser_v4	CDS	631284	632930	.	+	0	Mb0552	Mb0552		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb0552, -, len: 548 aa. Equivalent to Rv0538, len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Possible conserved membrane protein. Middle region highly similar to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein from Mycobacterium bovis (295 aa) possible transmembrane protein with a repetitive proline, threonine-rich region at C-terminus.	Q7U1T8,A0A1R3XVN3	No	cell wall and cell processes			A0A1R3XVN3					Q7U1T8					Rv0538		Rv0538			
NC_002945.3	Mycobrowser_v4	CDS	632987	633619	.	+	0	Mb0553	Mb0553		PROBABLE DOLICHYL-PHOSPHATE SUGAR SYNTHASE (DOLICHOL-PHOSPHATE SUGAR SYNTHETASE) (DOLICHOL-PHOSPHATE SUGAR TRANSFERASE) (SUGAR PHOSPHORYLDOLICHOL SYNTHASE)	Mb0553, -, len: 210 aa. Equivalent to Rv0539, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Probable dolichol-P-sugar synthase (EC 2.4.1.-), highly similar to CAB76989.1|AL159178 putative glycosyltransferase from Streptomyces coelicolor (242 aa), and similar to various dolichol-P-sugar synthetases and sugar transferases e.g. NP_126257.1|NC_000868 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED PROTEIN from Pyrococcus abyssi (211 aa); N-terminus of NP_127133.1|NC_000868 DOLICHOL-P-GLUCOSE SYNTHETASE from Pyrococcus abyssi (378 aa); N-terminus of NP_068880.1|NC_000917 putative dolichol-P-glucose synthetase from Archaeoglobus fulgidus (369 aa), FASTA scores: E(): 2.4e-13, (32. 1% identity in 193 aa overlap); Q26732 DOLICHYL-PHOSPHATE-MANNOSE SYNTHASE PRECURSOR from TRYPANOSOMA BRUCEI (267 aa), FASTA scores: opt: 179, E(): 0.0011, (30.7% identity in 205 aa overlap); etc. Also similar to Rv2051c|MTY25D10_18 from Mycobacterium tuberculosis. Contains S00017 ATP/GTP-binding site motif A (P-loop).	X2BFC3,P0A598,P0A598	No	intermediary metabolism and respiration			P0A598					X2BFC3,P0A598					Rv0539		Rv0539			
NC_002945.3	Mycobrowser_v4	CDS	633616	634278	.	+	0	Mb0554	Mb0554		CONSERVED HYPOTHETICAL PROTEIN	Mb0554, -, len: 220 aa. Equivalent to Rv0540, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Streptomyces coelicolor: CAB76990.1|AL159178 (213 aa); N-terminus of BAA84086.1|AB032065 (446 aa); and CAB61872.1|AL133252|SCE46_21 (210 aa), FASTA scores: opt: 267, E(): 5.3e-10, (32.7% identity in 202 aa overlap). Also some similarity with D90913_63|PCC6803 from Synecho cystis sp (211 aa), FASTA scores: opt: 189, E(): 4.7e-06,(25.3 identity in 194 aa overlap).	Q7U1T7,A0A1R3XVN1	No	conserved hypotheticals			A0A1R3XVN1				IPR018641	Q7U1T7					Rv0540		Rv0540			
NC_002945.3	Mycobrowser_v4	CDS	634299	635648	.	-	0	Mb0555c	Mb0555c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0555c, -, len: 449 aa. Equivalent to Rv0541c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 449 aa overlap). Probable conserved integral membrane protein, highly similar (except first 40 residues) to CAB76994.1|AL159178 putative integral membrane protein from Streptomyces coelicolor (456 aa). Also some similarity to Q13724|GCS1_HUMAN MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (834 aa), FASTA scores: opt: 150, E(): 0.013, (27.1% identity in 339 aa overlap). Contains PS00041 Bacterial regulatory proteins,araC family signature.	Q7U1T6,A0A1R3XVN5	No	cell wall and cell processes			A0A1R3XVN5					Q7U1T6					Rv0541c		Rv0541c			
NC_002945.3	Mycobrowser_v4	CDS	637179	637457	.	-	0	Mb0558c	Mb0558c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0558c, -, len: 92 aa. Equivalent to Rv0544c, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Possible conserved transmembrane protein, equivalent to NP_302470.1|NC_002677 possible membrane protein from Mycobacterium leprae (96 aa); and shows some similarity to MLU15187_33|Q50172|U296V from Mycobacterium leprae (36 aa), FASTA scores: opt: 151,E(): 2.1e-05, (71.4% identity in 35 aa overlap). Also some similarity with VATL_NEPNO|Q26250 vacuolar ATP synthase 16 kd proteolipid from Nephrops norvegicus (159 aa), FASTA scores: opt: 80, E(): 11, (26.1% identity in 88 aa overlap).	Q7U1T3,A0A1R3XVS2	No	cell wall and cell processes			A0A1R3XVS2					Q7U1T3					Rv0544c		Rv0544c			
NC_002945.3	Mycobrowser_v4	CDS	658791	659282	.	-	0	Mb0581c	Mb0581c		conserved protein	Mb0581c, -, len: 163 aa. Equivalent to Rv0566c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to others e.g. P77482|YAJQ_ECOLI HYPOTHETICAL 19.0 KDa PROTEIN from Escherichia coli (169 aa), FASTA scores: opt: 422, E(): 5.4e-20, (44.1 identity in 161 aa overlap); etc.	X2BFI9,P67381	No	conserved hypotheticals			P67381					X2BFI9					Rv0566c		Rv0566c			
NC_002945.3	Mycobrowser_v4	CDS	638827	639213	.	-	0	Mb0560c	Mb0560c		conserved protein	Mb0560c, -, len: 128 aa. Equivalent to Rv0546c,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, equivalent to AAA63111.1|U15187|Q50174|U296X hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 748,E(): 0, (84.2% identity in 133 aa overlap). Also highly similar to CAB95979.1|AL360034 conserved hypothetical protein from Streptomyces coelicolor (130 aa); and similar to AE000854_8|O26852 S-D-LACTOYLGLUTATHIONE METHYLGLYOXAL LYASE from Methanobacterium thermoautotropto (116 aa),FASTA scores: opt: 155, E(): 0.00019, (30.6% identity in 108 aa overlap); YAER_ECOLI hypothetical 14.7 kd protein from Escherichia coli (129 aa), FASTA scores: opt: 104,E(): 0.42, (28.7% identity in 115 aa overlap). Also similar to Rv2068c from Mycobacterium tuberculosis.	Q7U1T2,A0A1R3XVN2	No	conserved hypotheticals			A0A1R3XVN2				IPR004360	Q7U1T2					Rv0546c		Rv0546c			
NC_002945.3	Mycobrowser_v4	CDS	639276	640160	.	-	0	Mb0561c	Mb0561c		POSSIBLE OXIDOREDUCTASE	Mb0561c, -, len: 294 aa. Equivalent to Rv0547c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases e.g. fatty acyl-CoA reductase from Acinetobacter calcoaceticus (295 aa); NP_280196.1|NC_002607 3-oxoacyl-[acyl-carrier-protein] reductase from Halobacterium sp. NRC-1 (255 aa); NP_349214.1|NC_003030 Short-chain alcohol dehydrogenase family protein from Clostridium acetobutylicum (255 aa); etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Y04M_MYCTU|Q10783 putative oxidoreductase (341 aa), FASTA scores: opt: 644, E(): 0,(46.1% identity in 258 aa overlap).	Q7U1T1,A0A1R3XVR9	No	intermediary metabolism and respiration			A0A1R3XVR9				IPR002198,IPR002347,IPR016040	Q7U1T1					Rv0547c		Rv0547c			
NC_002945.3	Mycobrowser_v4	CDS	644132	645736	.	+	0	Mb0567	Mb0567		conserved protein	Mb0567, -, len: 534 aa. Equivalent to Rv0552, len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 534 aa overlap). Conserved hypothetical protein, similar to others from several organisms. Also shows some similarity with regulatory proteins e.g. AEPA_ERWCA|Q06555 exoenzymes regulatory protein aepA [Precursor] from Erwinia carotovora (465 aa),FASTA scores: opt: 278, E(): 7.6e-11, (23.0% identity in 408 aa overlap). Also similar to Z99119|BSUB0016_28 from Bacillus subtilis (529 aa), FASTA scores: opt: 436, E(): 8.3e-20, (23.8% identity in 547 aa overlap). C-terminus is similar to MLRRNOPR_1 HYPOTHETICAL 17.7 KD PROTEIN from Mycobacterium leprae (154 aa), FASTA score: (43.1% identity in 160 aa overlap).	Q7U1S6,A0A1R3XWQ5	No	conserved hypotheticals			A0A1R3XWQ5				IPR011059,IPR013108	Q7U1S6					Rv0552		Rv0552			
NC_002945.3	Mycobrowser_v4	CDS	651650	651988	.	-	0	Mb0574c	Mb0574c		POSSIBLE CONSERVED SECRETED PROTEIN	Mb0574c, -, len: 112 aa. Equivalent to Rv0559c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Possible conserved secreted protein, similar to NP_302481.1|NC_002677 putative secreted protein from Mycobacterium leprae (112 aa). Also similar to Y08B_MYCTU|Q11048 hypothetical 11.6 kd protein FASTA scores: opt: 111, E(): 011, (25.4% identity in 114 aa overlap). Contains possible N-terminal signal sequence.	Q7U1S1,A0A1R3XVQ1	No	cell wall and cell processes			A0A1R3XVQ1				IPR007969	Q7U1S1					Rv0559c		Rv0559c			
NC_002945.3	Mycobrowser_v4	CDS	652772	653998	.	-	0	Mb0576c	Mb0576c		POSSIBLE OXIDOREDUCTASE	Mb0576c, -, len: 408 aa. Equivalent to Rv0561c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar (except in first 30 aa) to NP_302482.1|NC_002677 putative FAD-linked oxidoreductase from Mycobacterium leprae (408 aa). Also similar to T34627 probable electron transfer oxidoreductase from Streptomyces coelicolor (430 aa); and some bacteriochlorophyll synthases e.g. NP_069300.1|NC_000917 bacteriochlorophyll synthase from Archaeoglobus fulgidus (410 aa); Q55087 GERANYLGERANYL HYDROGENASE (407 aa), FASTA scores: opt: 208, E(): 1.7e-06, (26.9% identity in 327 aa overlap).	Q7U1R9,A0A1R3XXV8	No	intermediary metabolism and respiration			A0A1R3XXV8				IPR002938,IPR003042,IPR011777	Q7U1R9					Rv0561c		Rv0561c			
NC_002945.3	Mycobrowser_v4	CDS	705997	707154	.	-	0	Mb0627c	Mb0627c		HYPOTHETICAL PROTEIN	Mb0627c, -, len: 385 aa. Equivalent to Rv0610c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 385 aa overlap). Hypothetical unknown protein.	Q7U1M6,A0A1R3XVZ8	No	conserved hypotheticals			A0A1R3XVZ8					Q7U1M6					Rv0610c		Rv0610c			
NC_002945.3	Mycobrowser_v4	CDS	657253	658713	.	-	0	Mb0580c	Mb0580c		PROBABLE MONOOXYGENASE	Mb0580c, -, len: 486 aa. Equivalent to Rv0565c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 486 aa overlap). Probable monoxygenase (EC 1.14.-.-), highly similar to NP_301173.1|NC_002677 putative monooxygenase from Mycobacterium leprae (494 aa). Also highly similar to others e.g. NP_421371.1|NC_002696 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa); C-terminus of NP_051574.1|NC_000958 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa); P12015|CYMO_ACISP CYCLOHEXANONE MONOOXYGENASE (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: opt: 354, E(): 2.1e-16, (23.7% identity in 435 aa overlap); etc. Also similar to other putative monoxygenases from Mycobacterium tuberculosis e.g. Rv3854c (489 aa), MTCY01A6.14 (489 aa), MTV013_4 (495 aa),MTCY31.20 (495 aa).	Q7U1R7,A0A1R3XVQ7	No	intermediary metabolism and respiration			A0A1R3XVQ7					Q7U1R7					Rv0565c		Rv0565c			
NC_002945.3	Mycobrowser_v4	CDS	659564	660583	.	+	0	Mb0582	Mb0582		PROBABLE METHYLTRANSFERASE/METHYLASE	Mb0582, -, len: 339 aa. Equivalent to Rv0567, len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 339 aa overlap). Probable methyltransferase (EC 2.1.1.-), similar to several e.g. P39896|TCMO_STRGA TETRACENOMYCIN POLYKETIDE SYNTHESIS 8-O-METHYLTRANSFERASE from Streptomyces glaucescens (339 aa), FASTA scores: opt: 685, E(): 0, (35.8% identity in 335 aa overlap); P10950|HIOM_BOVIN HYDROXYINDOLE O-METHYLTRANSFERASE (EC 2.1.1.4) from Bos taurus (345 aa),FASTA scores: opt: 509, E(): 3.4e-27, (30.7% identity in 332 aa overlap) etc.	Q7U1R6,A0A1R3XVQ6	No	intermediary metabolism and respiration			A0A1R3XVQ6				IPR001077,IPR011991,IPR016461	Q7U1R6					Rv0567		Rv0567			
NC_002945.3	Mycobrowser_v4	CDS	683128	685515	.	-	0	Mb0600c	Mb0600c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0600c, -, len: 795 aa. Equivalent to Rv0585c,len: 795 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 795 aa overlap). Probable conserved integral membrane protein. C-terminus similar to CAB88984.1|AL353864 putative integral membrane protein from Streptomyces coelicolor (299 aa); and C-terminal region of CAC01311.1|AL390968 putative integral membrane protein from Streptomyces coelicolor (925 aa). Also some similarity with Rv0204 from Mycobacterium tuberculosis.	Q7U1Q0,A0A1R3XVW2	No	cell wall and cell processes			A0A1R3XVW2				IPR011009,IPR022791	Q7U1Q0					Rv0585c		Rv0585c			
NC_002945.3	Mycobrowser_v4	CDS	662246	662512	.	+	0	Mb0584	Mb0584		conserved protein	Mb0584, -, len: 88 aa. Equivalent to Rv0569, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Conserved hypothetical protein. C-terminus highly similar to AAA63065.1|U15184|MLU15184_10 hypothetical protein from Mycobacterium leprae (53 aa), FASTA scores: opt: 140, E(): 0.0046, (64.7% identity in 34 aa overlap). Also similar to T36824|SCI35.11 hypothetical protein from Streptomyces coelicolor (64 aa); and N-terminus of T36956 probable DNA-binding protein from Streptomyces coelicolor (323 aa). Also highly similar to Rv2302|MTCY339.07c|NP_216818.1|NC_000962 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (80 aa), FASTA scores: opt: 300, E(): 1.4e-13, (61.8% identity in 76 aa overlap).	Q7U1R5,A0A1R3XVQ9	No	conserved hypotheticals			A0A1R3XVQ9				IPR011067,IPR015035	Q7U1R5					Rv0569		Rv0569			
NC_002945.3	Mycobrowser_v4	CDS	664729	666060	.	-	0	Mb0586c	Mb0586c		conserved protein	Mb0586c, -, len: 443 aa. Equivalent to Rv0571c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 443 aa overlap). Conserved hypothetical protein, highly similar to the products of two adjacent orfs in Mycobacterium leprae: AAA63059.1|U15184|U650S|Q50111 hypothetical protein (258 aa), FASTA scores: opt: 1071, E(): 0, (72.5% identity in 233 aa overlap); and AAA63058.1|U15184|U650T hypothetical protein (86 aa), FASTA scores: opt: 192, E(): 6.4e-06,(70.8% identity in 48 aa overlap). Also similar to others e.g. NP_107072.1|NC_002678 hypothetical protein from Mesorhizobium loti (235 aa); NP_213031.1|NC_000918 hypothetical protein from Aquifex aeolicus (175 aa); etc. And similar to part of hypothetical proteins from Mycobacterium tuberculosis e.g. C-terminus of Rv2143|MTCY270.25c|Z95388|NP_216659.1|NC_000962 (352 aa),FASTA scores: opt: 592, E(): 7e-32, (49.3% identity in 205 aa overlap); N-terminus of Rv2030c|NP_216546.1|NC_000962 (681 aa).	Q7U1R3,A0A1R3XXW8	No	conserved hypotheticals			A0A1R3XXW8				IPR000836	Q7U1R3					Rv0571c		Rv0571c			
NC_002945.3	Mycobrowser_v4	CDS	666284	666625	.	-	0	Mb0587c	Mb0587c		HYPOTHETICAL PROTEIN	Mb0587c, -, len: 113 aa. Equivalent to Rv0572c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 113 aa overlap). Hypothetical unknown protein.	Q7U1R2,A0A1R3XWS5	No	conserved hypotheticals			A0A1R3XWS5					Q7U1R2					Rv0572c		Rv0572c			
NC_002945.3	Mycobrowser_v4	CDS	668494	669636	.	-	0	Mb0589c	Mb0589c		CONSERVED HYPOTHETICAL PROTEIN	Mb0589c, -, len: 380 aa. Equivalent to Rv0574c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Conserved hypothetical protein, showing similarity with other hypothetical proteins and polyglutamate synthases (encapsulation proteins) e.g. AAK64444.1|AF377339_5|AF377339 polyglutamate synthase CapA from Myxococcus xanthus (405 aa); M24150|BACCAPABC_3|CapA polyglutamate synthase (encapsulation protein) from B.anthracis (411 aa), FASTA scores: opt: 261, E(): 4.3e-10, (25.8% identity in 287 aa overlap); etc.	Q7U1R0,A0A1R3XVR8	No	conserved hypotheticals			A0A1R3XVR8				IPR019079	Q7U1R0					Rv0574c		Rv0574c			
NC_002945.3	Mycobrowser_v4	CDS	699149	699655	.	-	0	Mb0616c	Mb0616c		two component sensor kinase [second part]	Mb0616c, -, len: 168 aa. Equivalent to Rv0600c,len: 168 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 168 aa overlap). Probable two-component sensor kinase (second part) (EC 2.7.3.-), similar to part (C-termini) of many others e.g. Q04943|AFQ2_STRCO sensor protein afsq2 from Streptomyces coelicolor (535 aa), FASTA scores: opt: 347,E(): 1.9e-12, (33.0% identity in 206 aa overlap); etc. Note that sequence was checked and no errors were detected, which would allow this and the upstream ORF to be joined.	Q7U1N6,A0A1R3XXZ2	No	regulatory proteins			A0A1R3XXZ2				IPR003594,IPR004358,IPR005467	Q7U1N6					Rv0600c		Rv0600c			
NC_002945.3	Mycobrowser_v4	CDS	669852	670988	.	-	0	Mb0590c	Mb0590c		POSSIBLE OXIDOREDUCTASE	Mb0590c, -, len: 378 aa. Equivalent to 5' end of Rv0575c, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 346 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786,E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 SALICYLATE HYDROXYLASE from SPHINGOMONAS (395 aa), FASTA scores: opt: 267, E():5e-11, (26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U1Q9,A0A1R3XVV2	No				A0A1R3XVV2				IPR002938,IPR003042	Q7U1Q9										
NC_002945.3	Mycobrowser_v4	CDS	671091	672395	.	+	0	Mb0591	Mb0591		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY)	Mb0591, -, len: 434 aa. Equivalent to Rv0576, len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 434 aa overlap). Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region (~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tuberculosis (107 aa). Contains helix-turn-helix motif at aa 23-43 (Score 1628, +4.73 SD).	Q7U1Q8,A0A1R3XVS0	No	regulatory proteins			A0A1R3XVS0				IPR001845,IPR011991,IPR013538,IPR017517,IPR017520,IPR023393	Q7U1Q8					Rv0576		Rv0576			
NC_002945.3	Mycobrowser_v4	CDS	760905	761078	.	+	0	Mb0685	Mb0685		POSSIBLE MEMBRANE PROTEIN	Mb0685, -, len: 57 aa. Equivalent to Rv0666, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Possible membrane protein; has hydrophobic stretch at aa 29-47.	Q7U1I1,A0A1R3XX24	No	cell wall and cell processes			A0A1R3XX24					Q7U1I1					Rv0666		Rv0666			
NC_002945.3	Mycobrowser_v4	CDS	677481	678239	.	+	0	Mb0594	Mb0594		CONSERVED HYPOTHETICAL PROTEIN	Mb0594, -, len: 252 aa. Equivalent to Rv0579, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Conserved hypothetical protein, showing some similarity to others e.g. AE001747_4 hypothetical protein from Thermotoga maritima (247 aa), FASTA scores: opt: 612, E(): 0, (39.6% identity in 235 aa overlap); AE001004_2 hypothetical protein from Archaeoglobus fulgidus (159 aa), FASTA scores: opt: 196, E(): 1e-06, (28.3% identity in 159 aa overlap); etc.	Q7U1Q6,A0A1R3XVS3	No	conserved hypotheticals			A0A1R3XVS3				IPR002782,IPR012675,IPR027798	Q7U1Q6					Rv0579		Rv0579			
NC_002945.3	Mycobrowser_v4	CDS	678368	678859	.	-	0	Mb0595c	Mb0595c		conserved protein	Mb0595c, -, len: 163 aa. Equivalent to Rv0580c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, equivalent to AAA90989.1|U20446|MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa). TBparse score is 0.910.	Q7U1Q5,A0A1R3XXX3	No	conserved hypotheticals			A0A1R3XXX3				IPR016791	Q7U1Q5					Rv0580c		Rv0580c			
NC_002945.3	Mycobrowser_v4	CDS	780759	781256	.	+	0	Mb0697	Mb0697		conserved protein	Mb0697, -, len: 165 aa. Equivalent to Rv0678, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical protein, showing weak similarity with AL049754|SCH10_10 hypothetical protein from Streptomyces coelicolor (152 aa), FASTA scores: opt: 149, E(): 0.0018,(22.9% identity in 140 aa overlap). TBparse score is 0.910.	Q7U1H3,A0A1R3XWH5	No	conserved hypotheticals			A0A1R3XWH5				IPR011991	Q7U1H3					Rv0678		Rv0678			
NC_002945.3	Mycobrowser_v4	CDS	680472	683105	.	+	0	Mb0599	Mb0599		POSSIBLE CONSERVED EXPORTED PROTEIN	Mb0599, -, len: 877 aa. Equivalent to Rv0584, len: 877 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 877 aa overlap). Possible conserved exported protein, similar to other hypothetical proteins which are not necessarily secreted e.g. CAB61925.1|AL133278 putative secreted protein from Streptomyces coelicolor (772 aa); AAD51075.1|AF175722_1|AF175722 immunoreactive 89kD antigen PG87 from Porphyromonas gingivalis (781 aa), FASTA scores: opt: 637, E(): 2.1e-30, (29.1% identity in 794 aa overlap); etc. Contains PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. Has potential N-terminal signal peptide.	Q7U1Q1,A0A1R3XVS9	No	cell wall and cell processes			A0A1R3XVS9				IPR005887,IPR008928,IPR012939,IPR014718	Q7U1Q1					Rv0584		Rv0584			
NC_002945.3	Mycobrowser_v4	CDS	707206	707589	.	-	0	Mb0628c	Mb0628c		HYPOTHETICAL PROTEIN	Mb0628c, -, len: 127 aa. Equivalent to Rv0611c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Hypothetical unknown protein. Note that first start has been taken although this overlaps slightly with the upstream ORF.	Q7U1M5,A0A1R3XWB7	No	conserved hypotheticals			A0A1R3XWB7					Q7U1M5					Rv0611c		Rv0611c			
NC_002945.3	Mycobrowser_v4	CDS	703261	704004	.	+	0	Mb0622	Mb0622		possible transposase (fragment)	Mb0622, -, len: 247 aa. Equivalent to Rv0606, len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Possible truncated transposase for IS_1536 element, highly similar to N-terminus of other transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (460 aa),FASTA scores: opt: 1368, E(): 0, (83.5% identity in 237 aa overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to N-terminus of MTV002_57|Rv2792 RESOLVASE from M. tuberculosis (193 aa), FASTA score: (87.4% identity in 238 aa overlap).	Q7U1N0,A0A1R3XVV9	No	insertion seqs and phages			A0A1R3XVV9				IPR001959,IPR021027	Q7U1N0					Rv0606		Rv0606			
NC_002945.3	Mycobrowser_v4	CDS	730572	731402	.	-	0	Mb0650c	Mb0650c		POSSIBLE EXPORTED PROTEIN	Mb0650c, -, len: 276 aa. Equivalent to Rv0633c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 279 aa overlap). Possible exported protein; has hydrophobic stretch at aa 23-41. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (cgggtgcgc-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (276 aa versus 279 aa).	Q7U1K7,A0A1R3XVY6	No	cell wall and cell processes			A0A1R3XVY6					Q7U1K7					Rv0633c		Rv0633c			
NC_002945.3	Mycobrowser_v4	CDS	696913	698148	.	-	0	Mb0613c	Mb0613c		CONSERVED HYPOTHETICAL PROTEIN	Mb0613c, -, len: 411 aa. Equivalent to Rv0597c,len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Conserved hypothetical protein, highly similar to Rv3179 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (429 aa). Also similar to AAF76191.1|AF271296_1|AF271296 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa); Rv2008c|YW09_MYCTU|Q10849 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (441 aa), FASTA scores: opt: 270, E(): 3.6e-11, (30.5% identity in 416 aa overlap) (N-terminus longer). Also similar to other hypothetical proteins e.g. NP_085874.1|NC_002679 hypothetical protein from Mesorhizobium loti (435 aa) (N-terminus longer). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U1N9,A0A1R3XVU2	No	conserved hypotheticals			A0A1R3XVU2				IPR025420,IPR027417	Q7U1N9					Rv0597c		Rv0597c			
NC_002945.3	Mycobrowser_v4	CDS	711829	712095	.	-	0	Mb0633c	Mb0633c		HYPOTHETICAL PROTEIN	Mb0633c, -, len: 88 aa. Equivalent to Rv0616c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein.	Q7U1M0,A0A1R3XVW1	No	conserved hypotheticals			A0A1R3XVW1					Q7U1M0					Rv0616c		Rv0616c			
NC_002945.3	Mycobrowser_v4	CDS	701101	701412	.	+	0	Mb0619	Mb0619		POSSIBLE EXPORTED PROTEIN	Mb0619, -, len: 103 aa. Equivalent to Rv0603, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(98.1% identity in 103 aa overlap). Possible exported protein with hydrophobic stretch at aa 7-29.	Q7U1N3,A0A1R3XWB1	No	cell wall and cell processes			A0A1R3XWB1					Q7U1N3					Rv0603		Rv0603			
NC_002945.3	Mycobrowser_v4	CDS	702651	703259	.	+	0	Mb0621	Mb0621		POSSIBLE RESOLVASE	Mb0621, -, len: 202 aa. Equivalent to Rv0605, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Possible resolvase for IS_Y349 element, similar to several Mycobacterial hypothetical proteins and weakly similar to Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa overlap). Contains PS00397 Site-specific recombinases active site and probable helix-turn helix motif from aa 9-30 (Score 1815, +5.37 SD).	Q7U1N1,A0A1R3XVY1	No	insertion seqs and phages			A0A1R3XVY1				IPR006118,IPR006119	Q7U1N1					Rv0605		Rv0605			
NC_002945.3	Mycobrowser_v4	CDS	707569	708174	.	+	0	Mb0629	Mb0629		CONSERVED HYPOTHETICAL PROTEIN	Mb0629, -, len: 201 aa. Equivalent to Rv0612, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Conserved hypothetical protein, highly similar, but in part, to downstream ORF Rv0609A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa); and showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis. Note that first start has been taken although this overlaps slightly with the upstream ORF.	Q7U1M4,A0A1R3XVV6	No	conserved hypotheticals			A0A1R3XVV6					Q7U1M4					Rv0612		Rv0612			
NC_002945.3	Mycobrowser_v4	CDS	4152372	4152563	.	-	0	Mb3798c	Mb3798c		PROBABLE REMNANT OF A TRANSPOSASE	Mb3798c, -, len: 63 aa. Equivalent to Rv3770B, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 379, E(): 1.6e-21, (93.55% identity in 62 aa overlap). Continues as Rv3770A.	Q7TVQ2,A0A1R3Y578	No	insertion seqs and phages			A0A1R3Y578					Q7TVQ2					Rv3770B		Rv3770B			
NC_002945.3	Mycobrowser_v4	CDS	708193	710760	.	-	0	Mb0630c	Mb0630c		unknown protein	Mb0630c, -, len: 855 aa. Equivalent to Rv0613c,len: 855 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 855 aa overlap). Hypothetical unknown protein. Contains a very short region with strong similarity to several preprotein translocases e.g. P47847|SECA_LISMO preprotein translocase seca subunit (836 aa), FASTA scores: opt: 138, E(): 0.18, (38.6% identity in 70 aa overlap, and 72.7% identity in 22 aa overlap).	Q7U1M3,A0A1R3XVZ0	No	conserved hypotheticals			A0A1R3XVZ0				IPR004027	Q7U1M3					Rv0613c		Rv0613c			
NC_002945.3	Mycobrowser_v4	CDS	710601	711593	.	+	0	Mb0631	Mb0631		CONSERVED HYPOTHETICAL PROTEIN	Mb0631, -, len: 330 aa. Equivalent to Rv0614, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Conserved hypothetical protein, similar in part to Mycobacterium tuberculosis hypothetical proteins e.g. YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c CONSERVED HYPOTHETICAL PROTEIN (323 aa), FASTA scores: opt: 200,E(): 0.00016, (28.3% identity in 269 aa overlap); MTCY9F9_15 FASTA score: (40.3% identity in 144 aa overlap), Rv1949c, Rv2542, etc. Several start sites are possible; first start has been chosen. Note that this ORF overlaps with the upstream ORF.	Q7U1M2,A0A1R3XVW8	No	conserved hypotheticals			A0A1R3XVW8					Q7U1M2					Rv0614		Rv0614			
NC_002945.3	Mycobrowser_v4	CDS	711590	711832	.	+	0	Mb0632	Mb0632		PROBABLE INTEGRAL MEMBRANE PROTEIN	Mb0632, -, len: 80 aa. Equivalent to Rv0615, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Probable integral membrane protein.	Q7U1M1,A0A1R3XVW0	No	cell wall and cell processes			A0A1R3XVW0					Q7U1M1					Rv0615		Rv0615			
NC_002945.3	Mycobrowser_v4	CDS	715448	716605	.	+	0	Mb0637	Mb0637		POSSIBLE MEMBRANE PROTEIN	Mb0637, -, len: 385 aa. Equivalent to Rv0621, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 354 aa overlap). Possible membrane protein; contains potential membrane spanning regions. Also contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa).	Q7U1L6,A0A1R3XWC6	No	cell wall and cell processes			A0A1R3XWC6					Q7U1L6					Rv0621		Rv0621			
NC_002945.3	Mycobrowser_v4	CDS	716616	717563	.	+	0	Mb0638	Mb0638		POSSIBLE MEMBRANE PROTEIN	Mb0638, -, len: 315 aa. Equivalent to Rv0622, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 315 aa overlap). Possible membrane protein; contains potential membrane spanning region. Shows weak similarity with Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, etc.	Q7U1L5,A0A1R3XVW5	No	cell wall and cell processes			A0A1R3XVW5				IPR007969	Q7U1L5					Rv0622		Rv0622			
NC_002945.3	Mycobrowser_v4	CDS	718399	719139	.	-	0	Mb0641c	Mb0641c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0641c, -, len: 246 aa. Equivalent to Rv0625c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Probable conserved transmembrane protein, showing similarity with others e.g. CAB61866.1|AL133252 putative integral membrane protein from Streptomyces coelicolor (249 aa). Also similar to Rv1491c|MTCY277_13 from Mycobacterium tuberculosis. Contains potential membrane spanning regions.	X2BFN9,P67116,P67116	No	cell wall and cell processes			P67116					X2BFN9,P67116					Rv0625c		Rv0625c			
NC_002945.3	Mycobrowser_v4	CDS	720007	721158	.	-	0	Mb0644c	Mb0644c		CONSERVED HYPOTHETICAL PROTEIN	Mb0644c, -, len: 383 aa. Equivalent to Rv0628c,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Conserved hypothetical protein, highly similar to Rv0874c|YZ02_MYCTU|Q10536 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 2082, E(): 0, (81.5% identity in 383 aa overlap). Also some similarity to P72543|SPU62616_1 HYPOTHETICAL PROTEIN from Synechococcus, FASTA scores: E(): 2.8e-28,(36.6 identity in 265 aa overlap).	X2BFF5,P64730,P64730	No	conserved hypotheticals			P64730					X2BFF5,P64730					Rv0628c		Rv0628c			
NC_002945.3	Mycobrowser_v4	CDS	751003	751698	.	-	0	Mb0672c	Mb0672c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb0672c, -, len: 231 aa. Equivalent to Rv0653c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible transcriptional regulator, TetR family, similar in N-terminus to others e.g. CAC03642.1|AL391338 putative TetR-family transcriptional regulator from Streptomyces coelicolor (190 aa); Q51597 CAM REPRESSOR from Pseudomonas putida (186 aa), FASTA scores: opt: 150, E(): 0.00085,(27.8% identity in 97 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis hypothetical transcriptional regulators Rv0681 and Rv1816. Contains probable helix-turn helix motif from aa 27-48 (Score 1156,+3.12 SD).	Q7U1J3,A0A1R3XVZ4	No	regulatory proteins			A0A1R3XVZ4				IPR001647,IPR009057,IPR011075,IPR015893,IPR025996	Q7U1J3					Rv0653c		Rv0653c			
NC_002945.3	Mycobrowser_v4	CDS	731556	732269	.	-	0	Mb0651c	Mb0651c		POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II)	Mb0651c, -, len: 237 aa. Equivalent to Rv0634c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Possible glyoxalase II (EC 3.1.2.6), equivalent to NP_302290.1|NC_002677 putative glyoxylase II from Mycobacterium leprae (238 aa); and similar to U00011_3|Y0BK_MYCLE|Q49649 hypothetical 23.9 kd protein from Mycobacterium leprae (218 aa), FASTA scores: opt: 281, E(): 3.9e-12, (31.8% identity in 201 aa overlap). Also similar to other glyoxalases and metallo-beta-lactamase family proteins e.g. NP_386770.1|NC_003047 PUTATIVE HYDROXYACYLGLUTATHIONE HYDROLASE from Sinorhizobium meliloti (256 aa); etc. Also similar to other putative glyoxylases from Mycobacterium tuberculosis e.g. Rv1637c. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS.	Q7U1K6,A0A1R3XVX3	No	virulence, detoxification, adaptation			A0A1R3XVX3				IPR001279	Q7U1K6					Rv0634c		Rv0634c			
NC_002945.3	Mycobrowser_v4	CDS	742387	743853	.	-	0	Mb0666c	Mb0666c		conserved protein	Mb0666c, -, len: 488 aa. Equivalent to Rv0647c,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Conserved hypothetical protein, equivalent to NP_302277.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (448 aa). Also showing similarity to a variety of hypothetical ABC1-LIKE proteins or conserved hypothetical proteins e.g. D90908_28|P73627 ABC1-LIKE PROTEIN from Synechocystis (585 aa), FASTA scores: E(): 1.8e-31, (29.1% identity in 474 aa overlap); Q55884 HYPOTHETICAL6 5.0 KD PROTEIN (567 aa),FASTA scores: opt: 583, E(): 5.7e-30, (28.1% identity in 416 aa overlap); etc. Also similar to Rv3197 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis.	Q7U1J7,A0A1R3XW38	No	conserved hypotheticals			A0A1R3XW38				IPR000719,IPR004147,IPR011009	Q7U1J7					Rv0647c		Rv0647c			
NC_002945.3	Mycobrowser_v4	CDS	744488	748135	.	+	0	Mb0667	Mb0667		ALPHA-MANNOSIDASE	Mb0667, -, len: 1215 aa. Equivalent to Rv0648, len: 1215 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 1215 aa overlap). Alpha-mannosidase (EC 3.2.1.-) (see citation below), showing some similarity to hypothetical proteins and various sugar hydrolases e.g. SYCSLRA_6|Q55528 HYPOTHETICAL 1 20.4 KD PROTEIN from Synechocystis (1042 aa), FASTA scores: opt: 260, E(): 3.6e-08, (23.4% identity in 602 aa overlap); etc. Contains PS00659 Glycosyl hydrolases family 5 signature.	Q7U1J6,A0A1R3XWE5	No	intermediary metabolism and respiration			A0A1R3XWE5				IPR000602,IPR011013,IPR011330,IPR011682,IPR013780,IPR013783,IPR015341,IPR018905,IPR027291	Q7U1J6					Rv0648		Rv0648			
NC_002945.3	Mycobrowser_v4	CDS	748806	749714	.	+	0	Mb0669	Mb0669		POSSIBLE SUGAR KINASE	Mb0669, -, len: 302 aa. Equivalent to Rv0650, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Possible sugar kinase, highly similar to others e.g. CAB95296.1|AL359779 putative sugar kinase from Streptomyces coelicolor (317 aa); NP_406512.1|NC_003143 putative sugar kinase from Yersinia pestis (290 aa); NP_229269.1|NC_000853 glucokinase from Thermotoga maritima (317 aa); etc.Contains PS01125 ROK family signature. BELONGS TO THE ROK (NAGC/XYLR) FAMILY.	Q7U1J4,A0A1R3XW29	No	intermediary metabolism and respiration			A0A1R3XW29				IPR000600	Q7U1J4					Rv0650		Rv0650			
NC_002945.3	Mycobrowser_v4	CDS	751769	753274	.	+	0	Mb0673	Mb0673		PROBABLE DIOXYGENASE	Mb0673, -, len: 501 aa. Equivalent to Rv0654, len: 501 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 501 aa overlap). Probable dioxygenase (EC 1.-.-.-), highly similar to others eg AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase (involved in tetraene formation) from Streptomyces antibioticus (456 aa); CAB56138.1| AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); T51734 neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid dioxygenase) from Arabidopsis thaliana (538 aa); Q53353 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE from Pseudomonas paucimobilis (Sphingomonas paucimobilis), FASTA scores: opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa overlap); etc. Also some similarity with Rv0913c|MTCY21C12.07c POSSIBLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa), FASTA score: (29.5% identity in 522 aa overlap).	Q7U1J2,A0A1R3XW04	No	intermediary metabolism and respiration			A0A1R3XW04				IPR004294	Q7U1J2					Rv0654		Rv0654			
NC_002945.3	Mycobrowser_v4	CDS	755462	756178	.	-	0	Mb0677c	Mb0677c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0677c, -, len: 238 aa. Equivalent to Rv0658c,len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 238 aa overlap). Probable conserved integral membrane protein, similar to P33774|YPRB_ECOLI hypothetical 24.3 kd protein from Escherichia coli (217 aa), FASTA scores: opt: 174, E(): 5.3e-05, (25.6% identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis.	Q7U1I9,A0A1R3XWF5	No	cell wall and cell processes			A0A1R3XWF5				IPR003675	Q7U1I9					Rv0658c		Rv0658c			
NC_002945.3	Mycobrowser_v4	CDS	788868	789695	.	+	0	Mb0706	Mb0706		probable short-chain type dehydrogenase/reductase	Mb0706, -, len: 275 aa. Equivalent to Rv0687, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases (generally SDR family) e.g. U17129|RSU17129_7 short-chain dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 1112, E(): 0, (61.2% identity in 268 aa overlap); MMU34072_2 steroid dehydrogenase from Musmus culus (260 aa), FASTA scores: opt: 390, E(): 2.2e-17, (34.1% identity in 267 aa overlap); etc. Also similar to MTV002_16|O33292|Rv2750 DEHYDROGENASE from Mycobacterium tuberculosis (272 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature.	Q7U1G8,A0A1R3XW77	No	intermediary metabolism and respiration			A0A1R3XW77				IPR002198,IPR002347,IPR016040,IPR020904,IPR023985	Q7U1G8					Rv0687		Rv0687			
NC_002945.3	Mycobrowser_v4	CDS	769453	771366	.	-	0	Mb0688c	Mb0688c		POSSIBLE HYDROLASE	Mb0688c, -, len: 637 aa. Equivalent to Rv0669c,len: 637 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 637 aa overlap). Possible hydrolase (EC 3.-.-.-), highly similar to various hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 alkaline ceramidase from Pseudomonas aeruginosa (670 aa,) FASTA scores: opt: 1490,E(): 0, (41.2% identity in 651 aa overlap); NP_063946.1|NM_019893 mitochondrial ceramidase from Homo sapiens (761 aa); P_446098.1|NM_053646 N-acylsphingosine amidohydrolase 2 from Rattus norvegicus (761 aa); BAB09641.1|AB016885 neutral ceramidase from Arabidopsis thaliana (705 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U1I0,A0A1R3XW15	No	intermediary metabolism and respiration			A0A1R3XW15				IPR006823	Q7U1I0					Rv0669c		Rv0669c			
NC_002945.3	Mycobrowser_v4	CDS	775833	776555	.	+	0	Mb0693	Mb0693		CONSERVED HYPOTHETICAL PROTEIN	Mb0693, -, len: 240 aa. Equivalent to Rv0674, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Conserved hypothetical protein, highly similar to AC13063.1|AL445503 conserved hypothetical protein from Streptomyces coelicolor (268 aa); and similar to NP_438100.1|NC_003078 putative regulator of phenylacetic acid degradation ArsR family protein from Sinorhizobium meliloti (306 aa) and other proteins e.g. AB011837|AB011837_13 hypothetical protein from Bacillus halodurans (298 aa), FASTA scores: opt: 148, E(): 0.0081, (25.1% identity in 235 aa overlap); etc.	Q7U1H6,A0A1R3XW25	No	conserved hypotheticals			A0A1R3XW25				IPR012906,IPR013225	Q7U1H6					Rv0674		Rv0674			
NC_002945.3	Mycobrowser_v4	CDS	883922	884608	.	+	0	Mb0810	Mb0810		unknown protein	Mb0810, -, len: 228 aa. Equivalent to hypothetical protein MT0811, len: 242 aa, from Mycobacterium tuberculosis strain CDC1551 (94% identity with 228 aa overlap). Hypothetical unknown protein, equivalent to AAK45053.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 77 aa. Mb0810 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BG72,A0A1R3XWF9	No				A0A1R3XWF9					X2BG72										
NC_002945.3	Mycobrowser_v4	CDS	781312	781809	.	-	0	Mb0698c	Mb0698c		conserved threonine rich protein	Mb0698c, -, len: 165 aa. Equivalent to Rv0679c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical Thr-rich protein, similar in part to neighboring ORF Rv0680c (124 aa), FASTA score: (35.1% identity in 131 aa overlap); and Rv0314c (220 aa). Contains probable N-terminal signal sequence. TBparse score is 0.894.	Q7U1H2,A0A1R3XW26	No	conserved hypotheticals			A0A1R3XW26				IPR021417	Q7U1H2					Rv0679c		Rv0679c			
NC_002945.3	Mycobrowser_v4	CDS	781811	782185	.	-	0	Mb0699c	Mb0699c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0699c, -, len: 124 aa. Equivalent to Rv0680c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Possible conserved transmembrane protein, showing similarity with C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved hypothetical protein from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 175, E(): 2.2e-05, (31.4% identity in 102 aa overlap). Also some similarity to upstream ORF Rv0679c|MTV040.07c CONSERVED HYPOTHETICAL THREONINE RICH PROTEIN (124 aa), FASTA score: (35.1% identity in 131 aa overlap). Contains probable N-terminal signal sequence.	Q7U1H1,A0A1R3XW62	No	cell wall and cell processes			A0A1R3XW62				IPR021417	Q7U1H1					Rv0680c		Rv0680c			
NC_002945.3	Mycobrowser_v4	CDS	782490	783080	.	+	0	Mb0700	Mb0700		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)	Mb0700, -, len: 196 aa. Equivalent to Rv0681, len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable transcription regulator, TetR family, similar to others and especially many tetracycline repressors e.g. T34657 probable transcription regulator from Streptomyces coelicolor (189 aa); AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator from Bacillus subtilis (191 aa), FASTA scores: opt: 213,E(): 1.6e-07, (28.8% identity in 153 aa overlap); P09164|TER4_ECOLI TETRACYCLINE REPRESSOR PROTEIN from Escherichia coli (217 aa), FASTA scores: opt: 145, E(): 0.0068, (39.0% identity in 59 aa overlap); etc. Contains helix-turn-helix motif at aa 28-49 (Score 1020, +2.66 SD).	Q7U1H0,A0A1R3XW36	No	regulatory proteins			A0A1R3XW36				IPR001647,IPR009057,IPR011075,IPR015893,IPR025996	Q7U1H0					Rv0681		Rv0681			
NC_002945.3	Mycobrowser_v4	CDS	824688	825416	.	+	0	Mb0751	Mb0751		gcn5-related n-acetyltransferase	Mb0751, -, len: 242 aa. Equivalent to Rv0730, len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical protein, only equivalent to Z98756|MLCB2492_26 HYPOTHETICAL PROTEIN from Mycobacterium leprae (227 aa), FASTA scores: opt: 1180, E(): 0, (83.5% identity in 218 aa overlap).	O53794,A0A1R3XW83	No	intermediary metabolism and respiration			A0A1R3XW83				IPR000182,IPR013760,IPR016181	O53794					Rv0730		Rv0730			
NC_002945.3	Mycobrowser_v4	CDS	810568	811467	.	+	0	Mb0733	Mb0733		conserved protein	Mb0733, -, len: 299 aa. Equivalent to Rv0712, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Conserved hypothetical protein, similar to others e.g. NP_106128.1|NC_002678 hypothetical protein from Mesorhizobium loti (372 aa); D90901_33|P72841 HYPOTHETICAL 48.1 KD PROTEIN from Synechocystis sp (410 aa), FASTA scores: E(): 1.1e-07, (28.8% identity in 299 aa overlap); etc. Slight similarity to carboxykinases. Similar to C-terminal part of Rv3703c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (425 aa).	Q7U1F1,A0A1R3XYB4	No	conserved hypotheticals			A0A1R3XYB4				IPR005532,IPR016187	Q7U1F1					Rv0712		Rv0712			
NC_002945.3	Mycobrowser_v4	CDS	789709	790929	.	+	0	Mb0707	Mb0707		PUTATIVE FERREDOXIN REDUCTASE	Mb0707, -, len: 406 aa. Equivalent to Rv0688, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Putative ferredoxin reductase (EC 1.-.-.-), highly similar to others e.g. BAB55881.1|AB054975 ferredoxin reductase from Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); PPU24215_8|Q51973 P-CUMATE DIOXYGENASE FERREDOXIN REDUCTASE SUBUNIT from Pseudomonas putida (402 aa), FASTA scores: opt: 738, E(): 0, (38.8% identity in 330 aa overlap); etc. Also similar to Rv0253 and Rv1869c from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY.	Q7U1G7,A0A1R3XWI4	No	intermediary metabolism and respiration			A0A1R3XWI4				IPR001327,IPR004099,IPR013027,IPR016156,IPR023753,IPR028202	Q7U1G7					Rv0688		Rv0688			
NC_002945.3	Mycobrowser_v4	CDS	790926	791180	.	-	0	Mb0708c	Mb0708c		HYPOTHETICAL PROTEIN	Mb0708c, -, len: 84 aa. Equivalent to Rv0689c, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Hypothetical unknown protein.	Q7U1G6,A0A1R3XW37	No	conserved hypotheticals			A0A1R3XW37					Q7U1G6					Rv0689c		Rv0689c			
NC_002945.3	Mycobrowser_v4	CDS	791793	792842	.	-	0	Mb0709c	Mb0709c		CONSERVED HYPOTHETICAL PROTEIN	Mb0709c, -, len: 349 aa. Equivalent to Rv0690c,len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Conserved hypothetical protein, showing similarity with NP_386956.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063 AGR_L_1570p from Agrobacterium tumefaciens (346 aa); NP_421938.1|NC_002696 conserved hypothetical protein from Caulobacter crescentus (370 aa).	Q7U1G5,A0A1R3XW72	No	conserved hypotheticals			A0A1R3XW72				IPR011200	Q7U1G5					Rv0690c		Rv0690c			
NC_002945.3	Mycobrowser_v4	CDS	792839	793435	.	-	0	Mb0710c	Mb0710c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0710c, -, len: 198 aa. Equivalent to Rv0691c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 198 aa overlap). Rv0691c,(MTCY210.08c), len: 198 aa. Probable transcriptional regulator, highly similar to AAC77476.1|U17129 unknown protein from Rhodococcus erythropolis (185 aa); and showing similarity with putative regulatory proteins eg STMTCREP_1|TCMR_STRGA|P39885 tetracenomycin c transcriptional repressor from Streptomyces glaucescens (226 aa), FASTA scores: opt: 178, E(): 8.5e-06, (27.9% identity in 201 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and probable helix-turn helix motifs from aa 34-55 (Score 1100, +2.93 SD) and 151-172 (Score 1124, +3.02 SD).	Q7U1G4,A0A1R3XW46	No	regulatory proteins			A0A1R3XW46				IPR001647,IPR009057,IPR015893,IPR023851	Q7U1G4					Rv0691c		Rv0691c			
NC_002945.3	Mycobrowser_v4	CDS	793427	793615	.	+	0	Mb0710A	Mb0710A		Mycofactocin precursor protein	Mb0710A, len: 62 aa. Equivalent to Rv0691A len: 62 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Mycofactocin precursor protein.	X2BFW7,A0A1R3XW42	No	intermediary metabolism and respiration			A0A1R3XW42					X2BFW7					Rv0691A		Rv0691A			
NC_002945.3	Mycobrowser_v4	CDS	793600	793929	.	+	0	Mb0711	Mb0711		CONSERVED HYPOTHETICAL PROTEIN	Mb0711, -, len: 109 aa. Equivalent to Rv0692, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Conserved hypothetical protein, highly similar to U17129|RSU17129_3|AAC77477.1 unknown protein from Rhodococcus erythropolis (95 aa), FASTA scores: opt: 393,E(): 8.8e-22, (68.2% identity in 88 aa overlap).	Q7U1G3,A0A1R3XW34	No	conserved hypotheticals			A0A1R3XW34				IPR023850	Q7U1G3					Rv0692		Rv0692			
NC_002945.3	Mycobrowser_v4	CDS	819361	820266	.	-	0	Mb0746c	Mb0746c		CONSERVED HYPOTHETICAL PROTEIN	Mb0746c, -, len: 301 aa. Equivalent to Rv0725c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c, Rv0731c,Rv3399, etc, e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical 36.1 kd protein cy31.21c (325 aa), FASTA scores: opt: 600,E(): 3.9e-32, (43.8% identity in 219 aa overlap).	X2BFZ0,Q7U1E7,Q7U1E7	No	conserved hypotheticals			Q7U1E7					X2BFZ0,Q7U1E7					Rv0725c		Rv0725c			
NC_002945.3	Mycobrowser_v4	CDS	1600239	1601066	.	-	0	Mb1463c	Mb1463c		CONSERVED HYPOTHETICAL PROTEIN	Mb1463c, -, len: 275 aa. Equivalent to Rv1428c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins from M. tuberculosis e.g. Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: opt: 355, E(): 5e-16, (32.6% identity in 273 aa overlap); and Rv1920.	Q7U036,A0A1R3XYQ3	No	conserved hypotheticals			A0A1R3XYQ3				IPR002123,IPR016676	Q7U036					Rv1428c		Rv1428c			
NC_002945.3	Mycobrowser_v4	CDS	796484	797239	.	+	0	Mb0714	Mb0714		CONSERVED HYPOTHETICAL PROTEIN	Mb0714, -, len: 251 aa. Equivalent to Rv0695, len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Conserved hypothetical protein, similar to many creatinine amidohydrolases or hypothetical proteins e.g. NP_443048.1|NC_000911 creatinine amidohydrolase from Synechococcus sp. PCC 6803 (273 aa); NP_466169.1|NC_003210 protein similar to creatinine amidohydrolase from Listeria monocytogenes (249 aa); T35153|SC5A7.04c hypothetical protein from Streptomyces coelicolor (273 aa); etc. Note that highly similar to RSU17129_10|AAC77474.1|U17129 unknown protein from Rhodococcus erythropolis (230 aa),FASTA scores: opt: 693, E(): 0, (55.7% identity in 237 aa overlap).	Q7U1G0,A0A1R3XX53	No	conserved hypotheticals			A0A1R3XX53				IPR003785,IPR023871,IPR024087	Q7U1G0					Rv0695		Rv0695			
NC_002945.3	Mycobrowser_v4	CDS	797288	798700	.	+	0	Mb0715	Mb0715		PROBABLE MEMBRANE SUGAR TRANSFERASE	Mb0715, -, len: 470 aa. Equivalent to Rv0696, len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 470 aa overlap). Probable membrane sugar transferase (EC 2.-.-.-), similar (except in N-terminus) to NP_069157.1|NC_000917 glycosyl transferase from Archaeoglobus fulgidus (324 aa); NP_279985.1|NC_002607 rhamnosyl transferase from Halobacterium sp. NRC-1 (299 aa); NP_059113.1|NM_017417 polypeptide N-acetylgalactosaminyltransferase 8 from (637 aa). Note that also highly similar to P46370|YTH1_RHOER HYPOTHETICAL 55.3 KDA PROTEIN from Rhodococcus erythropolis (513 aa), FASTA scores: opt: 1514, E(): 0,(51.8% identity in 469 aa overlap).	Q7U1F9,A0A1R3XW90	No	intermediary metabolism and respiration			A0A1R3XW90				IPR001173,IPR023981	Q7U1F9					Rv0696		Rv0696			
NC_002945.3	Mycobrowser_v4	CDS	798702	800141	.	+	0	Mb0716	Mb0716		PROBABLE DEHYDROGENASE	Mb0716, -, len: 479 aa. Equivalent to Rv0697, len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Probable dehydrogenase (EC 1.-.-.-), highly similar to P30772|YTUR_MYCLE HYPOTHETICAL 24 KD PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 557,E(): 1.7e-28, (46.2% identity in 223 aa overlap). Also highly similar to P46371|YTH2_RHOER HYPOTHETICAL 53.0 KDA GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa); and similar to many dehydrogenases e.g. NP_250814.1|NC_002516 probable dehydrogenase from Pseudomonas aeruginosa (545 aa); BAA13145.1|D86622 FAD dependent L-sorbose dehydrogenase from Gluconobacter oxydans (531 aa); etc. Also similar to Rv1279 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis.	Q7U1F8,A0A1R3XWJ3	No	intermediary metabolism and respiration			A0A1R3XWJ3				IPR000172,IPR007867,IPR012132,IPR023978	Q7U1F8					Rv0697		Rv0697			
NC_002945.3	Mycobrowser_v4	CDS	800602	800931	.	+	0	Mb0717	Mb0717		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb0717, -, len: 109 aa. Equivalent to 5' end of Rv0698, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 106 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 2.1e-07, (54.8% identity in 73 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718.	Q7U1F7,A0A1R3XW44	No				A0A1R3XW44					Q7U1F7										
NC_002945.3	Mycobrowser_v4	CDS	800979	801212	.	+	0	Mb0718	Mb0718		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb0718, -, len: 77 aa. Equivalent to 3' end of Rv0698, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 77 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 2.1e-07, (54.8% identity in 73 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718.	Q7U1F6,A0A1R3XW82	No				A0A1R3XW82					Q7U1F6										
NC_002945.3	Mycobrowser_v4	CDS	801397	801618	.	+	0	Mb0719	Mb0719		HYPOTHETICAL PROTEIN	Mb0719, -, len: 73 aa. Equivalent to Rv0699, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Hypothetical unknown protein.	Q7U1F5,A0A1R3XW55	No	conserved hypotheticals			A0A1R3XW55					Q7U1F5					Rv0699		Rv0699			
NC_002945.3	Mycobrowser_v4	CDS	2130721	2130939	.	+	0	Mb1926	Mb1926		CONSERVED HYPOTHETICAL PROTEIN	Mb1926, -, len: 72 aa. Equivalent to Rv1893, len: 72 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Conserved hypothetical protein. Equivalent to MLCB561.11|AL049571 hypothetical protein from Mycobacterium leprae (74 aa), FASTA scores: opt: 317, E(): 4.6e-15, (69.4% identity in 72 aa overlap).	Q7TZC4,A0A1R3XZN1	No	conserved hypotheticals			A0A1R3XZN1					Q7TZC4					Rv1893		Rv1893			
NC_002945.3	Mycobrowser_v4	CDS	1619634	1620044	.	-	0	Mb1479c	Mb1479c		unknown protein	Mb1479c, -, len: 136 aa. Equivalent to Rv1444c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Hypothetical unknown protein.	Q7U024,A0A1R3XYC3	No	conserved hypotheticals			A0A1R3XYC3				IPR022788	Q7U024					Rv1444c		Rv1444c			
NC_002945.3	Mycobrowser_v4	CDS	2194218	2194763	.	+	0	Mb1992	Mb1992		HYPOTHETICAL PROTEIN	Mb1992, -, len: 181 aa. Equivalent to Rv1957, len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Hypothetical unknown protein.	Q7TZ75,A0A1R3XZV0	No	conserved hypotheticals			A0A1R3XZV0				IPR003708	Q7TZ75					Rv1957		Rv1957			
NC_002945.3	Mycobrowser_v4	CDS	1174393	1175148	.	-	0	Mb1080c	Mb1080c		CONSERVED HYPOTHETICAL PROTEIN	Mb1080c, -, len: 251 aa. Equivalent to Rv1051c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 251 aa overlap). Conserved hypothetical protein, similar to LLU36837|U36837.1 protein encoded by Lactococcus lactis plasmid pNP40 (298 aa), FASTA scores: opt: 194, E(): 3.5e-06, (30.3% identity in 155 aa overlap). Contains possible helix-turn-helix motif at aa 197-218 (Score 1097, +2.92 SD).	Q7U0S5,A0A1R3XX93	No	conserved hypotheticals			A0A1R3XX93				IPR009061,IPR011991,IPR014942	Q7U0S5					Rv1051c		Rv1051c			
NC_002945.3	Mycobrowser_v4	CDS	811768	812709	.	+	0	Mb0734	Mb0734		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0734, -, len: 313 aa. Equivalent to Rv0713, len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 313 aa overlap). Probable conserved transmembrane protein, similar to Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis (284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35.8% identity in 282 aa overlap); MLCB2492_12|O32991 HYPOTHETICAL 10.7 KD PROTEIN from Mycobacterium leprae (95 aa).	Q7U1F0,A0A1R3XX72	No	cell wall and cell processes			A0A1R3XX72				IPR027948	Q7U1F0					Rv0713		Rv0713			
NC_002945.3	Mycobrowser_v4	CDS	1176171	1176560	.	+	0	Mb1081	Mb1081		HYPOTHETICAL PROTEIN	Mb1081, -, len: 129 aa. Equivalent to Rv1052, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Hypothetical unknown protein.	Q7U0S4,A0A1R3XX76	No	conserved hypotheticals			A0A1R3XX76					Q7U0S4					Rv1052		Rv1052			
NC_002945.3	Mycobrowser_v4	CDS	825505	826461	.	-	0	Mb0752c	Mb0752c		possible s-adenosylmethionine-dependent methyltransferase	Mb0752c, -, len: 318 aa. Equivalent to Rv0731c,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c|MTCY210.45c (367 aa), FASTA score: (60.9% identity in 317 aa overlap); Rv3399, Rv1729c, etc.	X2BFU1,O53795,O53795	No	lipid metabolism			O53795					X2BFU1,O53795					Rv0731c		Rv0731c			
NC_002945.3	Mycobrowser_v4	CDS	976541	977329	.	+	0	Mb0901	Mb0901		CONSERVED HYPOTHETICAL PROTEIN	Mb0901, -, len: 262 aa. Equivalent to Rv0877, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Conserved hypothetical protein, equivalent to MLCB57_13|O33058 conserved hypothetical protein from Mycobacterium leprae (269 aa), FASTA scores: E(): 0, (80.5% identity in 257 aa overlap). Also highly similar (except in C-terminus) to SCD12A.13|CAB93404.1|AL357524 hypothetical protein from Streptomyces coelicolor (308 aa).	X2BGF3,P64734	No	conserved hypotheticals			P64734					X2BGF3					Rv0877		Rv0877			
NC_002945.3	Mycobrowser_v4	CDS	820359	821462	.	-	0	Mb0747c	Mb0747c		possible s-adenosylmethionine-dependent methyltransferase	Mb0747c, -, len: 367 aa. Equivalent to Rv0726c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 367 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa),FASTA scores: opt: 646, E(): 0, (38.3% identity in 329 aa overlap); Rv0731c|MTV041.05c (318 aa), Rv3399, etc. Also similar to proteins from Mycobacterium leprae and other organisms e.g. T35930 hypothetical protein SC9B5.10 from Streptomyces coelicolor (303 aa).	X2BFT7,Q7U1E6,Q7U1E6	No	lipid metabolism			Q7U1E6					X2BFT7,Q7U1E6					Rv0726c		Rv0726c			
NC_002945.3	Mycobrowser_v4	CDS	1176459	1176734	.	-	0	Mb1082c	Mb1082c		HYPOTHETICAL PROTEIN	Mb1082c, -, len: 91 aa. Equivalent to Rv1053c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 91 aa overlap). Hypothetical unknown protein.	Q7U0S3,A0A1R3XX80	No	conserved hypotheticals			A0A1R3XX80					Q7U0S3					Rv1053c		Rv1053c			
NC_002945.3	Mycobrowser_v4	CDS	831029	831526	.	+	0	Mb0758	Mb0758		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0758, -, len: 165 aa. Equivalent to Rv0737, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Possible transcriptional regulator, similar to others e.g. BAB69161.1|AB070937 regulator protein from Streptomyces avermitilis (169 aa); NP_419731.1|NC_002696 transcriptional regulator MarR family from Caulobacter crescentus (148 aa) (homology only at C-terminus); etc. Also shows weak similarity to AB0014|AB001488_14 hypothetical protein from Bacillus subtilis (164 aa),FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in 116 aa overlap), which is similar to slyY gene of S. typhimurium required for survival in macrophage. Contains possible helix-turn helix motif from aa 73-94 (Score 1138,+3.06 SD).	O53800,A0A1R3XWB9	No	regulatory proteins			A0A1R3XWB9				IPR000835,IPR011991	O53800					Rv0737		Rv0737			
NC_002945.3	Mycobrowser_v4	CDS	831884	832432	.	+	0	Mb0759	Mb0759		conserved protein	Mb0759, -, len: 182 aa. Equivalent to Rv0738, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Conserved hypothetical protein, showing weak similarity with hypothetical proteins from Mycobacterium tuberculosis: Rv1727|MTCY04C12.12 (189 aa); MTY13D12_7|Z80343 hypothetical protein from Mycobacterium tuberculosis (194 aa), FASTA scores: opt: 172, E(): 0.0004, (24.2% identity in 178 aa overlap); and C-terminus of Rv0576.	Q7U1E2,A0A1R3XW99	No	conserved hypotheticals			A0A1R3XW99				IPR017517,IPR017520,IPR024344	Q7U1E2					Rv0738		Rv0738			
NC_002945.3	Mycobrowser_v4	CDS	832637	833485	.	+	0	Mb0760	Mb0760		CONSERVED HYPOTHETICAL PROTEIN	Mb0760, -, len: 282 aa. Equivalent to Rv0739, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Conserved hypothetical protein, showing some similarity to Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA score: (37.6% identity in 101 aa overlap)and Rv0025 (120 aa), FASTA score: (32.4% identity in 142 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2 bp insertion (*-cg) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa).	Q7U1E1,A0A1R3XW88	No	conserved hypotheticals			A0A1R3XW88				IPR019710	Q7U1E1					Rv0739		Rv0739			
NC_002945.3	Mycobrowser_v4	CDS	1184463	1185326	.	+	0	Mb1090	Mb1090		conserved protein	Mb1090, -, len: 287 aa. Equivalent to Rv1061, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 287 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from various bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803 (304 aa), FASTA scores: opt: 245, E(): 1.2e-09, (27.1% identity in 258 aa overlap).	Q7U0R5,A0A1R3XXA0	No	conserved hypotheticals			A0A1R3XXA0				IPR017932,IPR026869	Q7U0R5					Rv1061		Rv1061			
NC_002945.3	Mycobrowser_v4	CDS	833600	834127	.	+	0	Mb0761	Mb0761		CONSERVED HYPOTHETICAL PROTEIN	Mb0761, -, len: 175 aa. Equivalent to Rv0740, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Conserved hypothetical protein; C-terminus (possibly part of truncated IS1557) shows nearly perfect identity to Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% identity in 81 aa overlap). Also shows weak similarity to MTV007_5 hypothetical protein from Mycobacterium tuberculosis (313 aa), FASTA score: (34.5% identity in 110 aa overlap); and MLCL536_27 hypothetical protein from Mycobacterium leprae (315 aa), FASTA score: (34.5% identity in 84 aa overlap).	Q7U1E0,A0A1R3XW86	No	conserved hypotheticals			A0A1R3XW86					Q7U1E0					Rv0740		Rv0740			
NC_002945.3	Mycobrowser_v4	CDS	834358	834672	.	+	0	Mb0762	Mb0762		probable transposase (fragment)	Mb0762, -, len: 104 aa. Equivalent to Rv0741, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable truncated transposase for IS1557, showing similarity to transposases and IS elements e.g. U63997|EFU63997_1 insertion sequence from Enterococcus faecium (424 aa), FASTA score: (31.0% identity in 87 aa overlap). Very high similarity with the C-terminal part of Z73419|MTCY373_3 2 IS1557 from Mycobacterium tuberculosis (444 aa), FASTA score: (86.5% identity in 104 aa overlap).	Q7U1D9,A0A1R3XW94	No	insertion seqs and phages			A0A1R3XW94				IPR002560	Q7U1D9					Rv0741		Rv0741			
NC_002945.3	Mycobrowser_v4	CDS	835710	836267	.	-	0	Mb0764c	Mb0764c		HYPOTHETICAL PROTEIN	Mb0764c, -, len: 185 aa. Equivalent to Rv0743c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Hypothetical unknown protein.	Q7U1D7,A0A1R3XXA2	No	conserved hypotheticals			A0A1R3XXA2					Q7U1D7					Rv0743c		Rv0743c			
NC_002945.3	Mycobrowser_v4	CDS	836264	836770	.	-	0	Mb0765c	Mb0765c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0765c, -, len: 168 aa. Equivalent to Rv0744c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Possible transcriptional regulator, showing weak similarity with O86661|SC4A2.05 PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (436 aa), FASTA scores: opt: 117,E(): 0.88, (37.25% identity in 94 aa overlap); and some putative excisionases or transposases. Also weakly similar to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (114 aa); and Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (148 aa). Equivalent to AAK45006 from Mycobacterium tuberculosis strain CDC1551 (179 aa) but shorter 11 aa. Contains probable helix-turn helix motif from aa 5-26 (Score 1350, +3.78 SD).	Q7U1D6,A0A1R3XWC8	No	regulatory proteins			A0A1R3XWC8				IPR009061,IPR010093	Q7U1D6					Rv0744c		Rv0744c			
NC_002945.3	Mycobrowser_v4	CDS	836978	837505	.	+	0	Mb0766	Mb0766		CONSERVED HYPOTHETICAL PROTEIN	Mb0766, -, len: 175 aa. Equivalent to Rv0745, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Conserved hypothetical protein; shows high similarity to a 50 aa region of Rv3649|Z95436|MTY15C10_3 CONSERVED HYPOTHETICAL PROTEIN, similar to ATP-dependent helicases, from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 225, E(): 7e-06, (70.0% identity in 50 aa overlap).	Q7U1D5,A0A1R3XWP4	No	conserved hypotheticals			A0A1R3XWP4					Q7U1D5					Rv0745		Rv0745			
NC_002945.3	Mycobrowser_v4	CDS	866329	866763	.	+	0	Mb0794	Mb0794		POSSIBLE 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD)	Mb0794, -, len: 144 aa. Equivalent to Rv0771, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible 4-carboxymuconolactone decarboxylase (EC 4.1.1.44),showing similarity with other carboxymuconolactone decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein from Pseudomonas putida (130 aa); P20370|DC4C_ACICA 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) from Acinetobacter sp. ADP1 (134 aa), FASTA scores: opt: 174,E(): 0.00075, (31.4% identity in 121 aa overlap); C-terminus of NP_421214.1|NC_002696 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Caulobacter crescentus (393 aa); C-terminus of T47115 probable 4-carboxymuconolactone decarboxylase / 3-oxoadipate enol-lactone hydrolase from Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative gamma carboxymuconolactone decarboxylase from Yersinia pestis (131 aa); etc.	Q7U1B3,A0A1R3XXC9	No	intermediary metabolism and respiration			A0A1R3XXC9				IPR003779	Q7U1B3					Rv0771		Rv0771			
NC_002945.3	Mycobrowser_v4	CDS	871173	871952	.	-	0	Mb0799c	Mb0799c		CONSERVED HYPOTHETICAL PROTEIN	Mb0799c, -, len: 259 aa. Equivalent to Rv0776c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Conserved hypothetical protein, similar (except first 50 aa) to P72737|D90900_57 hypothetical protein from Synechocystis sp. strain PCC 6803 (261 aa), FASTA scores: opt: 337, E(): 1.7e-15, (30.5% identity in 266 aa overlap).	Q7U1A9,A0A1R3XWD9	No	conserved hypotheticals			A0A1R3XWD9				IPR007362,IPR008306	Q7U1A9					Rv0776c		Rv0776c			
NC_002945.3	Mycobrowser_v4	CDS	883265	883903	.	-	0	Mb0809c	Mb0809c		conserved protein	Mb0809c, -, len: 212 aa, equivalent to hypothetical protein MT0810 from Mycobacterium tuberculosis strain CDC1551, len: 212 aa (100% identity with 212 aa overlap). Mb0809c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BG57,A0A1R3XWF3	No				A0A1R3XWF3					X2BG57										
NC_002945.3	Mycobrowser_v4	CDS	852532	852717	.	-	0	Mb0778c	Mb0778c		PUTATIVE TRANSPOSASE (FRAGMENT)	Mb0778c, -, len: 61 aa. Equivalent to Rv0755A, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 61 aa overlap). Putative transposase (possibly gene fragment), similar to C-terminal part of Q9EZM2|ISMav2|AF286339_1 putative transposase from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 284, E(): 5e-13, (83.02% identity in 53 aa overlap); and to SCJ11.25c|Q9RI80 possible noncomposite transposon transposase from Streptomyces coelicolor (283 aa).	Q7U1C4,A0A1R3XWD0	No	insertion seqs and phages			A0A1R3XWD0				IPR009057,IPR010921	Q7U1C4					Rv0755A		Rv0755A			
NC_002945.3	Mycobrowser_v4	CDS	852931	853656	.	-	0	Mb0779c	Mb0779c		unknown protein	Mb0779c, -, len: 241 aa. Equivalent to Rv0756c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Hypothetical unknown protein.	Q7U1C3,A0A1R3XWB4	No	conserved hypotheticals			A0A1R3XWB4					Q7U1C3					Rv0756c		Rv0756c			
NC_002945.3	Mycobrowser_v4	CDS	856015	856347	.	-	0	Mb0782c	Mb0782c		CONSERVED HYPOTHETICAL PROTEIN	Mb0782c, -, len: 110 aa. Equivalent to Rv0759c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Conserved hypothetical protein, highly similar (but shorter 45 aa in N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A HYPOTHETICAL HIT-LIKE PROTEIN from Mycobacterium leprae (155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity in 150 aa overlap). Also highly similar (but N-terminus always shorter) to HIT-like proteins and protein kinase inhibitors e.g. AAF72728.1|AF265258_1|AF265258 HIT-like protein from Rhodococcus sp. (141 aa); NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI) from Borrelia burgdorferi (149 aa) ; P94252|YHIT_BORBU|BB0379 HYPOTHETICAL HIT-LIKE PROTEIN from Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689 HIT (histidine triad) family protein from Thermoplasma volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa),FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity in 111 aa overlap); etc. Also shows similarity with Rv2613c|MTCY01A10.20A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20 HYPOTHETICAL HIT-LIKE PROTEIN (144 aa).	X2BFV7,P0A5B6,P0A5B6	No	conserved hypotheticals			P0A5B6					X2BFV7,P0A5B6					Rv0759c		Rv0759c			
NC_002945.3	Mycobrowser_v4	CDS	856456	856875	.	-	0	Mb0783c	Mb0783c		conserved protein	Mb0783c, -, len: 139 aa. Equivalent to Rv0760c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, similar to N-terminal part of Rv2042c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (265 aa), FASTA scores: opt: 150, E(): 4.1e-05, (28.7% identity in 136 aa overlap).	Q7U1C0,A0A1R3XYG6	No	conserved hypotheticals			A0A1R3XYG6				IPR002075	Q7U1C0					Rv0760c		Rv0760c			
NC_002945.3	Mycobrowser_v4	CDS	858114	858659	.	-	0	Mb0785c	Mb0785c		CONSERVED HYPOTHETICAL PROTEIN	Mb0785c, -, len: 181 aa. Equivalent to Rv0762c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Conserved hypothetical protein, showing weak similarity to D90907_77|P73575 HYPOTHETICAL 31.3KD PROTEIN from Synechocystis sp, FASTA scores: E(): 0.0012, (30.4% identity in 92 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U1B8,A0A1R3XWE9	No	conserved hypotheticals			A0A1R3XWE9					Q7U1B8					Rv0762c		Rv0762c			
NC_002945.3	Mycobrowser_v4	CDS	858662	858868	.	-	0	Mb0786c	Mb0786c		POSSIBLE FERREDOXIN	Mb0786c, -, len: 68 aa. Equivalent to Rv0763c, len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Possible ferredoxin,similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c PROBABLE CYTOCHROME P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 137, E(): 0.00013, (36.4% identity in 66 aa overlap). Also similar to putative ferredoxins Rv3503c and Rv1786 from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY.	Q7U1B7,A0A1R3XWR1	No	intermediary metabolism and respiration			A0A1R3XWR1					Q7U1B7					Rv0763c		Rv0763c			
NC_002945.3	Mycobrowser_v4	CDS	910860	911672	.	-	0	Mb0840c	Mb0840c		PROBABLE CONSERVED EXPORTED PROTEIN	Mb0840c, -, len: 270 aa. Equivalent to Rv0817c,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Probable conserved exported protein, with N-terminal signal sequence,equivalent (but shorter 13 aa) to U15182|MLU15182_22|U2266M probable exported protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1287,E(): 0, (73.0% identity in 270 aa overlap).	Q7U175,A0A1R3XWI7	No	cell wall and cell processes			A0A1R3XWI7				IPR021373	Q7U175					Rv0817c		Rv0817c			
NC_002945.3	Mycobrowser_v4	CDS	860226	861053	.	-	0	Mb0788c	Mb0788c		PROBABLE OXIDOREDUCTASE	Mb0788c, -, len: 275 aa. Equivalent to Rv0765c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar others e.g. P39071|DHBA_BACSU 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Bacillus subtilis (261 aa), FASTA scores: opt: 385, E(): 1.8e-17, (30.6% identity in 252 aa overlap); AAF81239.1|AF263012 putative beta-ketoacyl reductase from Streptomyces griseus (274 aa); NP_436514.1|NC_003037 putative oxidoreductase from Sinorhizobium meliloti (240 aa); etc. Also similar to several other oxidoreductases from Mycobacterium tuberculosis e.g. Rv1544|MTCY48.21, FASTA score: (32.6% identity in 267 aa overlap); etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature.	Q7U1B6,A0A1R3XWE2	No	intermediary metabolism and respiration			A0A1R3XWE2				IPR002198,IPR002347,IPR016040,IPR020904	Q7U1B6					Rv0765c		Rv0765c			
NC_002945.3	Mycobrowser_v4	CDS	862258	862899	.	-	0	Mb0790c	Mb0790c		CONSERVED HYPOTHETICAL PROTEIN	Mb0790c, -, len: 213 aa. Equivalent to Rv0767c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, showing weak similarity with AL133220|SCC75A_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (215 aa), FASTA scores: opt: 152, E(): 0.0048,(28.4% identity in 204 aa overlap).	X2BG56,P67433,P67433	No	conserved hypotheticals			P67433					X2BG56,P67433					Rv0767c		Rv0767c			
NC_002945.3	Mycobrowser_v4	CDS	864601	865347	.	+	0	Mb0792	Mb0792		PROBABLE DEHYDROGENASE/REDUCTASE	Mb0792, -, len: 248 aa. Equivalent to Rv0769, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 248 aa overlap). Probable dehydrogenase/reductase (EC 1.-.-.-), similar to others,especially short-chain type dehydrogenases/reductases and 3-oxoacyl-(acyl-carrier protein) reductases e.g. NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa); NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein) reductase from Bacillus halodurans (246 aa); P28643|FABG_CUPLA 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Cuphea lanceolata (320 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 536,E(): 6.5e-27, (37.7% identity in 247 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. MTCY02B10.14, FASTA score: (33.7% identity in 249 aa overlap); etc.	Q7U1B5,A0A1R3XWC3	No	intermediary metabolism and respiration			A0A1R3XWC3				IPR002198,IPR002347,IPR016040	Q7U1B5					Rv0769		Rv0769			
NC_002945.3	Mycobrowser_v4	CDS	865445	866332	.	+	0	Mb0793	Mb0793		PROBABLE DEHYDROGENASE/REDUCTASE	Mb0793, -, len: 295 aa. Equivalent to Rv0770, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable dehydrogenase/reductase, 3-hydroxyisobutyrate dehydrogenase family (EC 1.1.1.-), possibly 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) or 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60), similar to others e.g. P23523|GARR_ECOLI 2-HYDROXY-3-OXOPROPIONATE REDUCTASE (TARTRONATE SEMIALDEHYDE REDUCTASE) (TSAR) from Escherichia coli strain K12 (294 aa), FASTA scores: opt: 469, E(): 6.7e-22, (34.4% identity in 282 aa overlap); P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase (HIBADH) from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 439, E(): 4.3e-20, (34.9% identity in 269 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. SEEMS TO BELONG TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY.	Q7U1B4,A0A1R3XYH6	No	intermediary metabolism and respiration			A0A1R3XYH6				IPR002204,IPR006115,IPR008927,IPR013328,IPR015815,IPR016040	Q7U1B4					Rv0770		Rv0770			
NC_002945.3	Mycobrowser_v4	CDS	869629	870540	.	-	0	Mb0797c	Mb0797c		PROBABLE CONSERVED EXPORTED PROTEIN	Mb0797c, -, len: 303 aa. Equivalent to Rv0774c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 303 aa overlap). Possible conserved exported protein with hydrophobic region near N-terminus,highly similar, except in N-terminus, to Rv0519c|Z97831|MTY20G10.09c|O33364 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (300 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature, and PS00120 Lipases, serine active site. So could be a lipase (EC 3.1.-.-).	Q7U1B1,A0A1R3XWD7	No	cell wall and cell processes			A0A1R3XWD7				IPR000801,IPR006311	Q7U1B1					Rv0774c		Rv0774c			
NC_002945.3	Mycobrowser_v4	CDS	870596	871219	.	+	0	Mb0798	Mb0798		CONSERVED HYPOTHETICAL PROTEIN	Mb0798, -, len: 207 aa. Equivalent to Rv0775, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins e.g. ECAE000186_11|MG1655 HYPOTHETICAL PROTEIN from Escherichia coli strain K-12 (178 aa), FASTA scores: E(): 6.4e-05, (27.2% identity in 147 aa overlap); P41037|BIH_ECOLI hypothetical transcriptional regulator from Escherichia coli (103 aa), FASTA scores: opt: 138,E(): 0.003, (30.9% identity in 97 aa overlap); etc.	Q7U1B0,A0A1R3XWE8	No	conserved hypotheticals			A0A1R3XWE8				IPR001647,IPR009057,IPR015893	Q7U1B0					Rv0775		Rv0775			
NC_002945.3	Mycobrowser_v4	CDS	882124	883230	.	+	0	Mb0808	Mb0808		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb0808, -, len: 368 aa. Equivalent to 3' end of Rv0785, len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 368 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 from Deinococcus radiodurans (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FASTA scores: opt: 169, E(): 0.0014,(23.8% identity in 542 aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% identity in 587 aa overlap). And shows similarity with other dehydrogenases. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808.	Q7U1A2,A0A1R3XWF6	No				A0A1R3XWF6				IPR003953	Q7U1A2										
NC_002945.3	Mycobrowser_v4	CDS	874861	875481	.	-	0	Mb0802c	Mb0802c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0802c, -, len: 206 aa. Equivalent to Rv0779c,len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Possible conserved transmembrane protein, equivalent to Z95151|MLCB5_14 O05747 conserved hypothetical protein from Mycobacterium leprae (206 aa), FASTA scores: opt: 902, E(): 0, (67.2% identity in 204 aa overlap).	Q7U1A7,A0A1R3XWD3	No	cell wall and cell processes			A0A1R3XWD3					Q7U1A7					Rv0779c		Rv0779c			
NC_002945.3	Mycobrowser_v4	CDS	888027	888836	.	-	0	Mb0816c	Mb0816c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY)	Mb0816c, -, len: 269 aa. Equivalent to Rv0792c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 269 aa overlap). Probable transcriptional regulator, GntR-family, similar to many others of GntR family e.g. BSUB0018_189|Z99121 from Bacillus subtilis (243 aa), FASTA scores: opt: 367, E(): 1.5e-17, (32.1% identity in 246 aa overlap); P31453|YIDP_ECOLI from Escherichia coli (238 aa), FASTA scores: opt: 236, E(): 8.8e-09, (26.4% identity in 235 aa overlap); etc.	Q7U195,A0A1R3XWU6	No	regulatory proteins			A0A1R3XWU6				IPR000524,IPR011663,IPR011991	Q7U195					Rv0792c		Rv0792c			
NC_002945.3	Mycobrowser_v4	CDS	880829	881515	.	+	0	Mb0806	Mb0806		CONSERVED HYPOTHETICAL PROTEIN	Mb0806, -, len: 228 aa. Equivalent to Rv0784, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Conserved hypothetical protein, with some similarity to MLCB5_20|O05752 hypothetical protein from Mycobacterium leprae (193 aa), FASTA scores: opt: 141, E(): 0.0022,(36.0% identity in 114 aa overlap). Also similar to N-terminus of NP_253002.1|NC_002516 conserved hypothetical protein from Pseudomonas aeruginosa (253 aa).	Q7U1A4,A0A1R3XWT5	No	conserved hypotheticals			A0A1R3XWT5				IPR011330	Q7U1A4					Rv0784		Rv0784			
NC_002945.3	Mycobrowser_v4	CDS	881531	882106	.	+	0	Mb0807	Mb0807		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb0807, -, len: 191 aa. Equivalent to 5' end of Rv0785, len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, (97.1% identity in 140 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 from Deinococcus radiodurans (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FASTA scores: opt: 169, E(): 0.0014,(23.8% identity in 542 aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% identity in 587 aa overlap). And shows similarity with other dehydrogenases. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808.	Q7U1A3,A0A1R3XWF0	No				A0A1R3XWF0				IPR003953	Q7U1A3										
NC_002945.3	Mycobrowser_v4	CDS	884714	884953	.	+	0	Mb0811	Mb0811		conserved protein	Mb0811, -, len: 79 aa. Equivalent to Rv0787A, len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, equivalent to MLCB5.24 HYPOTHETICAL PROTEIN from Mycobacterium leprae (79 aa), FASTA scores: opt: 434,(84.8% identity in 79 aa overlap). Also similar to P12049|YEXA_BACSU HYPOTHETICAL 9.7 KD PROTEIN from Bacillus subtilis (84 aa), FASTA scores: opt: 172, E(): 4e-06, (44.4% identity in 72 aa overlap). BELONGS TO THE UPF0062 FAMILY.	Q7U199,A0A1R3XWG2	No	conserved hypotheticals			A0A1R3XWG2				IPR003850	Q7U199					Rv0787A		Rv0787A			
NC_002945.3	Mycobrowser_v4	CDS	886987	888030	.	-	0	Mb0815c	Mb0815c		conserved protein	Mb0815c, -, len: 347 aa. Equivalent to Rv0791c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Conserved hypothetical protein, similar (except in N-terminus) to others e.g. CAC44585.1|AL596162 conserved hypothetical protein from Streptomyces coelicolor (307 aa); NP_252643.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (364 aa); etc. Also some similarity with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); etc. And also similar in part to other proteins from Mycobacterium tuberculosis e.g. Rv1855c|MTCY359.18|Z83859 (307 aa), FASTA scores: opt: 366, E(): 4e-16, (35.0% identity in 226 aa overlap); Rv3079c|MTCY22D7.02|Z83866 CONSERVED HYPOTHETICAL PROTEIN (275 aa), FASTA scores: opt: 342, E(): 1.2e-14, (31.6% identity in 234 aa overlap); Rv0044c POSSIBLE OXIDOREDUCTASE (264 aa).	Q7U196,A0A1R3XWI0	No	conserved hypotheticals			A0A1R3XWI0				IPR011251,IPR019921	Q7U196					Rv0791c		Rv0791c			
NC_002945.3	Mycobrowser_v4	CDS	888909	889214	.	+	0	Mb0817	Mb0817		possible monooxygenase	Mb0817, -, len: 101 aa. Equivalent to Rv0793, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Conserved hypothetical protein, similar to others e.g. NP_250888.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (114 aa); AE 001908|AE001908_7 hypothetical protein from Deinococcus radiodurans (101 aa), FASTA scores: opt: 215, E(): 3.1e-09, (40.4% identity in 99 aa overlap); NP_440966.1|NC_000911|D90908|PCC6803|D90908_2 unknown protein from Synechocystis sp. strain PCC 6803 (147 aa),FASTA scores: opt: 194, E(): 4.5e-08, (31.1% identity in 90 aa overlap); etc. Also similar to Rv2749|MTV002.14|AL0089|MTV002_15 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 143, E(): 0.00026, (26.9% identity in 93 aa overlap).	Q7U194,A0A1R3XWG1	No	intermediary metabolism and respiration			A0A1R3XWG1				IPR007138,IPR011008	Q7U194					Rv0793		Rv0793			
NC_002945.3	Mycobrowser_v4	CDS	893096	894103	.	-	0	Mb0822c	Mb0822c		conserved protein	Mb0822c, -, len: 335 aa. Equivalent to Rv0799c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Conserved hypothetical protein, similar to Q50021|U2266C from Mycobacterium leprae (146 aa), FASTA scores: opt: 147,E(): 0.0016, (33.3% identity in 117 aa overlap); Q50020|U2266B from Mycobacterium leprae (27 aa), FASTA scores: opt: 94, E(): 1.3, (56.5% identity in 23 aa overlap). Also highly similar to others e.g. CAC01593.1|AL391041 conserved hypothetical protein from Streptomyces coelicolor (316 aa); AF088897|AF088897_9 hypothetical protein from Zymomonas mobilis (322 aa),FASTA scores: opt: 1132, E(): 0, (56.1% identity in 303 aa overlap); P76536|ECAE000330_8 hypothetical protein from Escherichia coli strain K-12 (308 aa), FASTA scores: E(): 2.2e-30, (37.4% identity in 297 aa overlap); etc. Also similar to some tyrA proteins.	Q7U189,A0A1R3XWG4	No	conserved hypotheticals			A0A1R3XWG4				IPR006314,IPR011008	Q7U189					Rv0799c		Rv0799c			
NC_002945.3	Mycobrowser_v4	CDS	889327	889938	.	-	0	Mb0818c	Mb0818c		PROBABLE OXIDOREDUCTASE [SECOND PART]	Mb0818c, -, len: 203 aa. Equivalent to 3' end of Rv0794c, len: 499 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 203 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa); and similar to various oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa); NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase, similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa); Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Haloferax volcanii (475 aa); P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity in 467 aa overlap); P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa overlap); etc. Note that previously known as lpdB. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Mb0818c into 2 parts, Mb0818 and Mb0819.	Q7U193,A0A1R3XWG6	No				A0A1R3XWG6				IPR004099,IPR016156	Q7U193										
NC_002945.3	Mycobrowser_v4	CDS	889926	890825	.	-	0	Mb0819c	Mb0819c		PROBABLE OXIDOREDUCTASE [FIRST PART]	Mb0819c, -, len: 299 aa. Equivalent to 5' end of Rv0794c, len: 499 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 263 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa); and similar to various oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa); NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase, similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa); Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Haloferax volcanii (475 aa); P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity in 467 aa overlap); P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa overlap); etc. Note that previously known as lpdB. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Mb0818c into 2 parts, Mb0818a and Mb0818b.	Q7U192,A0A1R3XWG0	No				A0A1R3XWG0				IPR001327,IPR013027,IPR023753	Q7U192										
NC_002945.3	Mycobrowser_v4	CDS	933752	934780	.	-	0	Mb0860c	Mb0860c		HYPOTHETICAL PROTEIN	Mb0860c, -, len: 342 aa. Equivalent to Rv0837c,len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 342 aa overlap). Hypothetical unknown protein. TBparse score is 0.941.	Q7U156,A0A1R3XWK7	No	conserved hypotheticals			A0A1R3XWK7				IPR016600,IPR019238	Q7U156					Rv0837c		Rv0837c			
NC_002945.3	Mycobrowser_v4	CDS	891218	892312	.	+	0	Mb0820	Mb0820		PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1547	Mb0820, -, len: 364 aa. Equivalent to Rv0797, len 364 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 364 aa overlap). Putative transposase for IS1547; almost identical to (but 20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium tuberculosis (383 aa). Also similar to other transposases e.g. MAIS1110A _1|Q48909 transposase from M. avium (464 aa), FASTA scores: opt: 226, E(): 2.4e-08, (30.7% identity in 199 aa overlap). Also slight similarity to Rv2014|MTCY39.03c from Mycobacterium tuberculosis (222 aa), FASTA score: (24.8% identity in 141 aa overlap).	Q7U191,A0A1R3XWH1	No	insertion seqs and phages			A0A1R3XWH1				IPR002525,IPR003346	Q7U191					Rv0797		Rv0797			
NC_002945.3	Mycobrowser_v4	CDS	906064	907170	.	-	0	Mb0834c	Mb0834c		conserved protein	Mb0834c, -, len: 368 aa. Equivalent to Rv0811c,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 368 aa overlap). Conserved hypothetical protein, equivalent to U2266F|U15182|MLU15182_13 HYPOTHETICAL PROTEIN from Mycobacterium leprae (366 aa), FASTA scores: opt: 1870,E(): 0, (77.4% identity in 367 aa overlap). Also highly similar to BAA89441.1|AB003158|ORF4 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (359 aa); and CAB94085.1|AL358692 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (321 aa).	Q7U180,A0A1R3XXG9	No	conserved hypotheticals			A0A1R3XXG9				IPR006222,IPR013977,IPR017703	Q7U180					Rv0811c		Rv0811c			
NC_002945.3	Mycobrowser_v4	CDS	895461	895808	.	+	0	Mb0824	Mb0824		conserved protein	Mb0824, -, len: 115 aa. Equivalent to Rv0801, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins from Streptomyces sp. e.g. SCD840A.20|AB81865.1|AL161691 hypothetical protein from Streptomyces coelicolor (145 aa); AF072709|AF072709_8 from Streptomyces lividans (131 aa), FASTA scores: opt: 120,E(): 0.2, (26.3% identity in 118 aa overlap); etc.	Q7U188,A0A1R3XXF9	No	conserved hypotheticals			A0A1R3XXF9				IPR025870	Q7U188					Rv0801		Rv0801			
NC_002945.3	Mycobrowser_v4	CDS	895802	896458	.	-	0	Mb0825c	Mb0825c		possible succinyltransferase in the gcn5-related n-acetyltransferase family	Mb0825c, -, len: 218 aa. Equivalent to Rv0802c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Conserved hypothetical protein, showing partial similarity with many acetyltransferases and hypothetical proteins e.g. P96579|BSUB0003_68 PROBABLE ACETYLTRANSFERASE from Bacillus subtilis (183 aa), FASTA scores: E(): 0.0044,(26.4% identity in 110 aa overlap).	Q7U187,A0A1R3XWJ0	No	intermediary metabolism and respiration			A0A1R3XWJ0				IPR000182,IPR016181	Q7U187					Rv0802c		Rv0802c			
NC_002945.3	Mycobrowser_v4	CDS	899661	900617	.	+	0	Mb0828	Mb0828		class iii cyclic nucleotide phosphodiesterase (cnmp pde)	Mb0828, -, len: 318 aa. Equivalent to Rv0805, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Conserved hypothetical protein, equivalent to Q50024 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa),FASTA scores: opt: 1713, E(): 0, (82.5% identity in 315 aa overlap). Also shows similarity with hypothetical proteins and icc proteins e.g. SC9B1.22c|T35867 hypothetical protein from Streptomyces coelicolor (305 aa); P36650|ICC_ECOLI icc protein from Escherichia coli (275 aa), FASTA scores: opt: 310, E(): 8.9e-14, (31.3% identity in 214 aa overlap); etc.	Q7U185,A0A1R3XWH6	No	intermediary metabolism and respiration			A0A1R3XWH6				IPR004843,IPR026575	Q7U185					Rv0805		Rv0805			
NC_002945.3	Mycobrowser_v4	CDS	948067	948399	.	+	0	Mb0873	Mb0873		PUTATIVE TRANSPOSASE (FRAGMENT)	Mb0873, -, len: 110 aa. Equivalent to Rv0850, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Putative transposase (fragment), similar in part to others e.g. Q45144|Q4514 TRANSPOSABLE ELEMENT IS31831 (436 aa), FASTA scores: opt: 175, E(): 4.3e-05, (38.6% identity in 57 aa overlap); etc.	Q7U143,A0A1R3XYQ0	No	insertion seqs and phages			A0A1R3XYQ0					Q7U143					Rv0850		Rv0850			
NC_002945.3	Mycobrowser_v4	CDS	902465	902854	.	+	0	Mb0830	Mb0830		CONSERVED HYPOTHETICAL PROTEIN	Mb0830, -, len: 129 aa. Equivalent to Rv0807, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, equivalent to O05761|MLCB5_31 HYPOTHETICAL 14.0 KD PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: E(): 0, (73.4% identity in 128 aa overlap). Also highly similar to BAA89438.1|AB003158|ORF3 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (132 aa); and C-terminus of SCD25.20|CAB56364.1|AL118514 hypothetical protein from Streptomyces coelicolor (202 aa).	Q7U183,A0A1R3XWH8	No	conserved hypotheticals			A0A1R3XWH8					Q7U183					Rv0807		Rv0807			
NC_002945.3	Mycobrowser_v4	CDS	1506219	1506581	.	-	0	Mb1377c	Mb1377c		CONSERVED MEMBRANE PROTEIN	Mb1377c, -, len: 120 aa. Equivalent to Rv1342c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 120 aa overlap). Conserved membrane protein. Highly similar to G466926|P54133 hypothetical protein B1549_F2_59 from Mycobacterium leprae (119 aa),FASTA scores, opt: 544, E(): 1.9e-29, (68.3 % identity in 120 aa overlap).	X2BHM0,P0A5E8,P0A5E8	No	cell wall and cell processes			P0A5E8					X2BHM0,P0A5E8					Rv1342c		Rv1342c			
NC_002945.3	Mycobrowser_v4	CDS	905735	905917	.	-	0	Mb0833c	Mb0833c		CONSERVED HYPOTHETICAL PROTEIN	Mb0833c, -, len: 60 aa. Equivalent to Rv0810c, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Conserved hypothetical protein, with its N-terminus highly similar to NP_302445.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (62 aa); and AL118514|SCD25_24 hypothetical protein from Streptomyces coelicolor (84 aa),FASTA scores: opt: 180, E(): 5.7e-07, (51.8% identity in 56 aa overlap). TBparse score is 0.876.	Q7U181,A0A1R3XYL1	No	conserved hypotheticals			A0A1R3XYL1				IPR021426	Q7U181					Rv0810c		Rv0810c			
NC_002945.3	Mycobrowser_v4	CDS	1230055	1230756	.	+	0	Mb1130	Mb1130		conserved protein	Mb1130, -, len: 233 aa. Equivalent to Rv1100, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 233 aa overlap). Conserved hypothetical protein, slightly similar to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 122, E(): 6.9, (27.4% identity in 135 aa overlap). Equivalent to AL049491|MLCB1222_9 Mycobacterium leprae (257 aa) (63.8% identity in 257 aa overlap).	Q7U0N4,A0A1R3XXC6	No	conserved hypotheticals			A0A1R3XXC6				IPR025339	Q7U0N4					Rv1100		Rv1100			
NC_002945.3	Mycobrowser_v4	CDS	907253	908122	.	+	0	Mb0835	Mb0835		PROBABLE AMINO ACID AMINOTRANSFERASE	Mb0835, -, len: 289 aa. Equivalent to Rv0812, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 289 aa overlap). Probable amino acid aminotransferase (EC 2.6.1.-), similar to other amino acid aminotransferases, generelly CLASS-IV OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, and especially ILVE proteins and PABC proteins e.g. B76065.1|AL157953 putative aminotransferase from Streptomyces coelicolor (273 aa); NP_069766.1|NC_000917 branched-chain amino acid aminotransferase (ilvE) from Archaeoglobus fulgidus (290 aa); P54692|DAAA_BACLI D-ALANINE AMINOTRANSFERASE from Bacillus licheniformis (283 aa); P28305|PABC_ECOLI 4-AMINO-4-DEOXYCHORISMATE LYASE From Escherichia coli (269 aa), FASTA scores: opt: 165, E(): 0.00064, (26.8% identity in 198 aa overlap); etc. Note that previously known as pabC.	Q7U179,A0A1R3XWK1	No	intermediary metabolism and respiration			A0A1R3XWK1				IPR001544	Q7U179					Rv0812		Rv0812			
NC_002945.3	Mycobrowser_v4	CDS	919742	920383	.	-	0	Mb0848c	Mb0848c		conserved protein	Mb0848c, -, len: 213 aa. Equivalent to Rv0825c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, highly similar, but in part (between aa ~43-96) to fadD27|Rv0275c|MTV035.03 PUTATIVE FATTY-ACID-COA LIGASE from Mycobacterium tuberculosis (241 aa), FASTA scores: E(): 7.3e-09, (32.6% identity in 190 aa overlap). Also shows similarity with other proteins from Mycobacterium tuberculosis e.g. Rv0078|AL0214|MTV030_22 (201 aa), FASTA scores: opt:118, E(): 0.32, (34.5% identity in 113 aa overlap); etc.	Q7U168,A0A1R3XWJ9	No	conserved hypotheticals			A0A1R3XWJ9				IPR001647,IPR009057,IPR015893	Q7U168					Rv0825c		Rv0825c			
NC_002945.3	Mycobrowser_v4	CDS	908168	908848	.	-	0	Mb0836c	Mb0836c		conserved protein	Mb0836c, -, len: 226 aa. Equivalent to Rv0813c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Conserved hypothetical protein, highly similar to U15182|MLU15182_16 HYPOTHETICAL PROTEIN from Mycobacterium leprae (242 aa),FASTA scores: opt: 1191, E(): 0, (78.3% identity in 226 aa overlap); and NP_302442.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (228 aa). Also similar to AB94083.1|AL358692|SCD66.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (191 aa); and Rv2717c|MTCY05A6_37 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (164 aa), FASTA score: (30.4% identity in 171 aa overlap).	X2BG93,Q7U178,Q7U178	No	conserved hypotheticals			Q7U178					X2BG93,Q7U178					Rv0813c		Rv0813c			
NC_002945.3	Mycobrowser_v4	CDS	911802	912569	.	+	0	Mb0841	Mb0841		TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0841, -, len: 255 aa. Equivalent to Rv0818, len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 255 aa overlap). Probable transcriptional regulatory protein, highly similar to Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 945, E(): 0, (61.5 identity in 239 aa overlap); and similar to others from other organisms. Also similar to Rv2884|MTCY274.15|Z74024 from Mycobacterium tuberculosis (252 aa), FASTA scores: opt: 662, E(): 0, (47.8% identity in 226 aa overlap).	Q7U174,A0A1R3XWJ5	No	regulatory proteins			A0A1R3XWJ5				IPR001867,IPR011006,IPR011991,IPR016032	Q7U174					Rv0818		Rv0818			
NC_002945.3	Mycobrowser_v4	CDS	915087	917141	.	-	0	Mb0845c	Mb0845c		conserved protein	Mb0845c, -, len: 684 aa. Equivalent to Rv0822c,len: 684 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 684 aa overlap). Conserved hypothetical protein, highly similar in the region between aa 370 - 580 to U2266O|U15182|MLU15182_30 HYPOTHETICAL PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 819,E(): 0, (60.6% identity in 221 aa overlap). More extended similarity to Rv3267|Z92771|MTCY71_7 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 434, E(): 2.2e-17, (26.6% identity in 541 aa overlap), and Rv3484. Also similar to various proteins, preferiously putative membrane proteins and membrane-bound regulatory proteins e.g. CAC44512.1|AL596138 putative membrane protein from Streptomyces coelicolor (524 aa); U56901|BSU56901_1 regulatory protein from Bacillus subtilis (391 aa), FASTA scores: opt: 225, E(): 1.3e-05, (24.7% identity in 340 aa overlap). Contains hydrophobic stretch (aa ~ 160-195) and PS00041 Bacterial regulatory proteins, araC family signature.	Q7U171,A0A1R3XWL2	No	conserved hypotheticals			A0A1R3XWL2				IPR004474,IPR027381	Q7U171					Rv0822c		Rv0822c			
NC_002945.3	Mycobrowser_v4	CDS	922405	922695	.	+	0	Mb0852	Mb0852		possible transposase (fragment)	Mb0852, -, len: 96 aa. Equivalent to Rv0829, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 96 aa overlap). Possible transposase for IS1605' (fragment), similar to C-terminal end of many mycobacterial transposases and hypothetical proteins e.g. Z74024|MTCY274_16 from Mycobacterium tuberculosis (460 aa), FASTA scores: opt: 668, E(): 6.2e-32, (98.9% identity in 93 aa overlap); MTV002_57|O33333 TRANSPOSASE from Mycobacterium tuberculosis ; L07627|SERRY1_1 insertion element IS1136 from Saccharopolyspora erythraea (90 aa),FASTA score: (34.9% identity in 83 aa overlap).	Q7U164,A0A1R3XWJ4	No	insertion seqs and phages			A0A1R3XWJ4				IPR010095	Q7U164					Rv0829		Rv0829			
NC_002945.3	Mycobrowser_v4	CDS	983227	984249	.	+	0	Mb0909	Mb0909		CONSERVED HYPOTHETICAL PROTEIN	Mb0909, -, len: 340 aa. Equivalent to Rv0885, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Conserved hypothetical protein, equivalent to O33063|MLCB57_18 possible transmembrane protein from Mycobacterium leprae (341 aa), FASTA score: (83.9% identity in 341 aa overlap). Also similar except in C-terminus to T35630 probable membrane protein from Streptomyces coelicolor (312 aa).	X2BGB3,P0A5D6,P0A5D6	No	conserved hypotheticals			P0A5D6					X2BGB3,P0A5D6					Rv0885		Rv0885			
NC_002945.3	Mycobrowser_v4	CDS	917307	918476	.	-	0	Mb0846c	Mb0846c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0846c, -, len: 389 aa. Equivalent to Rv0823c,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 389 aa overlap). Possible transcriptional regulator (resembles nitrogen regulation protein), equivalent (but longer 24 aa in N-terminus) to MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium leprae (384 aa), FASTA scores: opt: 2070, E(): 0, (82.3% identity in 384 aa overlap) (see citation below). Also highly similar to CAB63312.1|AL133471|SCC82.03c hypothetical protein from Streptomyces coelicolor (406 aa); and to many transcriptional regulators members of UPF0034 FAMILY (NIFR3/SMM1) e.g. D26185|BAC180K_143 protein similar to transcriptional regulator (nitrogen regulation protein) from Bacillus subtilis (333 aa), FASTA scores: opt: 609, E(): 1.4e-32, (38.3% identity in 326 aa overlap); NP_349795.1|NC_003030 NifR3 family enzyme from Clostridium acetobutylicum (321 aa); etc. Contains PS01136 Uncharacterized protein family UPF0034 signature.	Q7U170,A0A1R3XWX6	No	regulatory proteins			A0A1R3XWX6				IPR001269,IPR004652,IPR013785,IPR018517,IPR024036	Q7U170					Rv0823c		Rv0823c			
NC_002945.3	Mycobrowser_v4	CDS	1107894	1108550	.	-	0	Mb1017c	Mb1017c		HYPOTHETICAL PROTEIN	Mb1017c, -, len: 218 aa. Equivalent to Rv0990c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Hypothetical unknown protein.	Q7U0W6,A0A1R3XX16	No	conserved hypotheticals			A0A1R3XX16				IPR013974	Q7U0W6					Rv0990c		Rv0990c			
NC_002945.3	Mycobrowser_v4	CDS	920464	921519	.	+	0	Mb0849	Mb0849		CONSERVED HYPOTHETICAL PROTEIN	Mb0849, -, len: 351 aa. Equivalent to Rv0826, len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 351 aa overlap). Conserved hypothetical protein, similar to CAB94053.1|AL358672|SC7A12.06 hypothetical protein from Streptomyces coelicolor (300 aa); and NP_421372.1|NC_002696 hypothetical protein from Caulobacter crescentus (299 aa). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv1645c|Z85982|MTCY06H11.09 (351 aa), FASTA scores: opt: 1199, E(): 0, (57.5% identity in 299 aa overlap); Rv2237; Rv0276; etc.	Q7U167,A0A1R3XWI6	No	conserved hypotheticals			A0A1R3XWI6				IPR018713	Q7U167					Rv0826		Rv0826			
NC_002945.3	Mycobrowser_v4	CDS	1108623	1108955	.	-	0	Mb1018c	Mb1018c		conserved serine rich protein	Mb1018c, -, len: 110 aa. Equivalent to Rv0991c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Conserved hypothetical ser-rich protein (especially in C-terminus), highly similar to N-terminus of NP_301255.1|NC_002677 conserved hypothetical protein (Ser-rich C-terminus) from Mycobacterium leprae (99 aa). Also highly similar to SCE22.04|AB90971.1|AL355832 hypothetical protein from Streptomyces coelicolor (110 aa); and similar to others.	Q7U0W5,A0A1R3XX18	No	conserved hypotheticals			A0A1R3XX18				IPR013429	Q7U0W5					Rv0991c		Rv0991c			
NC_002945.3	Mycobrowser_v4	CDS	922021	922443	.	-	0	Mb0851c	Mb0851c		POSSIBLE DEAMINASE	Mb0851c, -, len: 140 aa. Equivalent to Rv0828c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Possible deaminase (EC 3.5.-.-), with its N-terminus highly similar to middle part of NP_302602.1|NC_002677 possible cytidine/deoxycytidylate deaminase from Mycobacterium leprae (171 aa). Also similar to other deaminases e.g. CAC18715.2|AL451182 putative deaminase from Streptomyces coelicolor (167 aa); NP_251189.1|NC_002516 probable deaminase from Pseudomonas aeruginosa (151 aa); NP_108387.1|NC_002678 nitrogen fixation protein gene from Mesorhizobium loti (149 aa); etc. Also similar to many conserved hypothetical proteins e.g. NP_389200.1|NC_000964 hypothetical protein from Bacillus subtilis (156 aa),FASTA scores: E(): 1.3e-07, (38.9% identity in 95 aa overlap); etc. And similar to Rv3752c possible deaminase from Mycobacterium tuberculosis. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY.	Q7U165,A0A1R3XWK4	No	intermediary metabolism and respiration			A0A1R3XWK4				IPR002125,IPR016192,IPR016193	Q7U165					Rv0828c		Rv0828c			
NC_002945.3	Mycobrowser_v4	CDS	922800	923705	.	+	0	Mb0853	Mb0853		possible s-adenosylmethionine-dependent methyltransferase	Mb0853, -, len: 301 aa. Equivalent to Rv0830, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, member of Mycobacterium tuberculosis protein family consisting of the proteins Rv0726c,Rv0731c, Rv3399, Rv1729c|Z81360|MTCY4C12_14c (312 aa),FASTA scores: opt: 1014, E(): 0, (54.1% identity in 292 aa overlap); etc.	X2BG66,Q7U163,Q7U163	No	lipid metabolism			Q7U163					X2BG66,Q7U163					Rv0830		Rv0830			
NC_002945.3	Mycobrowser_v4	CDS	923724	924539	.	-	0	Mb0854c	Mb0854c		conserved protein	Mb0854c, -, len: 271 aa. Equivalent to Rv0831c,len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 271 aa overlap). Conserved hypothetical protein, similar to Rv0347|MTY13E10_7|Z95324 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (328 aa), FASTA scores: opt: 426, E(): 2.6e-21, (33.6% identity in 262 aa overlap).	Q7U162,A0A1R3XXI9	No	conserved hypotheticals			A0A1R3XXI9				IPR026349	Q7U162					Rv0831c		Rv0831c			
NC_002945.3	Mycobrowser_v4	CDS	1771950	1772465	.	-	0	Mb1611c	Mb1611c		Possible phage phiRv1 protein	Mb1611c, -, len: 171 aa. Equivalent to Rv1585c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Possible phage phiRv1 protein (see citation below).	Q7VEX1,A0A1R3XYR1	No	insertion seqs and phages			A0A1R3XYR1					Q7VEX1					Rv1585c		Rv1585c			
NC_002945.3	Mycobrowser_v4	CDS	2003144	2004937	.	-	0	Mb1808c	Mb1808c		possible integral membrane protein	Mb1808c, -, len: 597 aa. Equivalent to Rv1779c,len: 597 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 597 aa overlap). Possible integral membrane protein.	Q7TZK0,A0A1R3XZA4	No	cell wall and cell processes			A0A1R3XZA4				IPR025519	Q7TZK0					Rv1779c		Rv1779c			
NC_002945.3	Mycobrowser_v4	CDS	1009409	1010527	.	+	0	Mb0930	Mb0930		conserved protein	Mb0930, -, len: 372 aa. Equivalent to Rv0906, len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 372 aa overlap). Conserved hypothetical protein, highly similar to others e.g. SC6A5.25|AL049485|T35416 hypothetical protein from Streptomyces coelicolor (370 aa), FASTA scores: opt: 1125,E(): 0, (51.3% identity in 335 aa overlap); NP_242955.1|NC_002570|BH2089 conserved protein from Bacillus halodurans (370 aa); etc. Also shows some similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer membrane protein roma (fragment) from Klebsiella pneumoniae (132 aa), FASTA scores: opt: 319, E(): 8.5e-14,(46.2% identity in 104 aa overlap); NP_105215.1|NC_002678 hypothetical protein which contains similarity to outer membrane protein romA from Enterobacter cloacae (350 aa); etc.	X2BGG4,P64760,P64760	No	conserved hypotheticals			P64760					X2BGG4,P64760					Rv0906		Rv0906			
NC_002945.3	Mycobrowser_v4	CDS	936332	937144	.	+	0	Mb0862	Mb0862		CONSERVED HYPOTHETICAL PROTEIN	Mb0862, -, len: 270 aa. Equivalent to Rv0839, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Conserved hypothetical protein, similar to various hypothetical proteins or methyltransferases from yeast and bacteria e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hypothetical protein from Streptomyces coelicolor (273 aa), FASTA scores: opt: 1102, E(): 0, (58.6% identity in 263 aa overlap); T38024|Z98598|SPAC1B3.06c hypothetical protein from Schizosaccharomyces pombe (278 aa), FASTA scores: opt: 562, E(): 1.9e-3, (36.4% identity in 269 aa overlap); JC6531 avermectin B 5-O-methyltransferase (EC 2.1.1.-) from Streptomyces avermitilis (283 aa); etc. Also similar to other Mycobacterium tuberculosis hypothetical proteins that may be methyltransferases e.g. Rv1523, Rv2952,Rv1405c, etc.	Q7U154,A0A1R3XWK5	No	conserved hypotheticals			A0A1R3XWK5				IPR025714	Q7U154					Rv0839		Rv0839			
NC_002945.3	Mycobrowser_v4	CDS	938348	938590	.	+	0	Mb0864	Mb0864		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0864, -, len: 80 aa. Equivalent to Rv0841, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 80 aa overlap). Conserved transmembrane protein, highly similar to C-terminus of next ORF Rv0842|O53854 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis (442 aa), FASTA scores: opt: 246, E(): 3.3e-10, (59.7% identity in 72 aa overlap). Replace previous Rv0841c.	Q7U152,A0A1R3XXJ9	No	cell wall and cell processes			A0A1R3XXJ9					Q7U152					Rv0841		Rv0841			
NC_002945.3	Mycobrowser_v4	CDS	938867	940159	.	+	0	Mb0865	Mb0865		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0865, -, len: 430 aa. Equivalent to Rv0842, len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 430 aa overlap). Probable conserved integral membrane protein, showing similarity with other integral membrane proteins e.g. P28246|BCR_ECOLI BICYCLOMYCIN RESISTANCE PROTEIN from EScherichia coli (396 aa), FASTA scores: opt: 216, E(): 5.4e-07, (23.7% identity in 376 aa overlap); etc.	Q7U151,A0A1R3XWN0	No	cell wall and cell processes			A0A1R3XWN0				IPR011701,IPR016196,IPR020846	Q7U151					Rv0842		Rv0842			
NC_002945.3	Mycobrowser_v4	CDS	940143	941147	.	+	0	Mb0866	Mb0866		PROBABLE DEHYDROGENASE	Mb0866, -, len: 334 aa. Equivalent to Rv0843, len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 334 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to various dehydrogenases e.g. Q46142|Q46142 TPP-DEPENDENT ACETOIN DEHYDROGENASE (326 aa), FASTA scores: opt: 500, E(): 2.4e-26, (32.3% identity in 300 aa overlap); P51267|ODPA_PORPU PYRUVATE DEHYDROGENASE E1 COMPONENT from Porphyra purpurea (344 aa), FASTA scores: opt: 451, E(): 4.7e-23, (29.6% identity in 311 aa overlap); etc. Also similar to Rv2497c|pdhA pyruvate dehydrogenase E1 component from Mycobacterium tuberculosis (367 aa).	Q7U150,A0A1R3XWZ4	No	intermediary metabolism and respiration			A0A1R3XWZ4				IPR001017	Q7U150					Rv0843		Rv0843			
NC_002945.3	Mycobrowser_v4	CDS	941945	943222	.	+	0	Mb0868	Mb0868		POSSIBLE TWO COMPONENT SENSOR KINASE	Mb0868, -, len: 425 aa. Equivalent to Rv0845, len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Possible two-component sensor kinase (EC 2.7.-.-), with its C-terminus similar to C-terminal part of others e.g. NP_294951.1|NC_001263 two-component sensor histidine kinase from Deinococcus radiodurans (469 aa); CAC32293.1|AL583943 putative two component system histidine kinase from Streptomyces coelicolor (404 aa); NP_464546.1|NC_003210 protein similar to two-component sensor histidine kinase from Listeria monocytogenes (352 aa); BSUB0017_193|Z9912 two-component sensor kinase from Bacillus subtilis (360 aa), FASTA scores: opt: 275, E(): 1.6e-11, (30.3% identity in 234 aa overlap); etc.	Q7U148,A0A1R3XWL8	No	regulatory proteins			A0A1R3XWL8				IPR003594,IPR005467	Q7U148					Rv0845		Rv0845			
NC_002945.3	Mycobrowser_v4	CDS	943435	944949	.	-	0	Mb0869c	Mb0869c		PROBABLE OXIDASE	Mb0869c, -, len: 504 aa. Equivalent to Rv0846c,len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 504 aa overlap). Probable oxidase (EC 1.-.-.-), showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins A (precursors) e.g. P24792|ASO_CUCMA L-ASCORBATE OXIDASE PRECURSOR (ASCORBASE) (EC 1.10.3.3) from Cucurbita maxima (Pumpkin) (Winter squash) (579 aa), FASTA scores: opt: 423, E(): 5.8e-18, (28.4% identity in 493 aa overlap); AF010496|AF010496_32 potential multicopper oxidase from Rhodobacter capsulatus (491 aa), FASTA scores: opt: 490,E(): 2.7e-22, (28.8% identity in 510 aa overlap); 47452|PCOA_ECOLI COPPER RESISTANCE PROTEIN A PRECURSOR (BELONGS TO THE FAMILY OF MULTICOPPER OXIDASES) from Escherichia coli strain K12 (605 aa); etc. Contains PS00080 Multicopper oxidases signature 2 at C-terminus. SEEMS TO BELONG TO THE FAMILY OF MULTICOPPER OXIDASES.	Q7U147,A0A1R3XWK6	No	intermediary metabolism and respiration			A0A1R3XWK6				IPR001117,IPR002355,IPR006311,IPR008972,IPR011706,IPR011707	Q7U147					Rv0846c		Rv0846c			
NC_002945.3	Mycobrowser_v4	CDS	1279265	1279672	.	+	0	Mb1180	Mb1180		POSSIBLE TRANSPOSASE	Mb1180, -, len: 135 aa. Equivalent to Rv1149, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 135 aa overlap). Possible transposase. Identical to 117 aa N-terminal region of S21394|X65618 transposase of Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1042c|MTCY10G2.07. TBparse score is 0.926.	Q7U0J2,A0A1R3XXH4	No	insertion seqs and phages			A0A1R3XXH4				IPR025161	Q7U0J2					Rv1149		Rv1149			
NC_002945.3	Mycobrowser_v4	CDS	946811	948070	.	+	0	Mb0872	Mb0872		PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN	Mb0872, -, len: 419 aa. Equivalent to Rv0849, len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 419 aa overlap). Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS) involved in transport of drug, showing similarity with others e.g. T35055 probable transport system permease protein from Streptomyces coelicolor (436 aa); NP_295031.1|NC_001263 major facilitator family protein from Deinococcus radiodurans (458 aa); NP_455659.1|NC_003198 putative membrane transporter from Salmonella enterica subsp. enterica serovar Typhi (402 aa); etc.	Q7U144,A0A1R3XWL5	No	cell wall and cell processes			A0A1R3XWL5				IPR011701,IPR016196,IPR020846	Q7U144					Rv0849		Rv0849			
NC_002945.3	Mycobrowser_v4	CDS	948396	949223	.	-	0	Mb0874c	Mb0874c		probable short-chain type dehydrogenase/reductase	Mb0874c, -, len: 275 aa. Equivalent to Rv0851c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 275 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to many e.g. Q01198|LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC 1.1.1.-)(SDR FAMILY) from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (305 aa); D11473|PSELIG_1 C alpha-dehydrogenase from P. paucimobilis (305 aa), FASTA scores: opt: 468, E(): 4.9e-23, (30.8% identity in 279 aa overlap); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7U142,A0A1R3XXK9	No	intermediary metabolism and respiration			A0A1R3XXK9				IPR002198,IPR002347,IPR016040,IPR020904	Q7U142					Rv0851c		Rv0851c			
NC_002945.3	Mycobrowser_v4	CDS	1016702	1017151	.	+	0	Mb0936	Mb0936		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0936, -, len: 149 aa. Equivalent to Rv0912, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 149 aa overlap). Probable conserved transmembrane protein, equivalent to Q50121|NP_302397.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 677, E(): 6.9e-38, (69.5% identity in 141 aa overlap).	Q7U117,A0A1R3XWU7	No	cell wall and cell processes			A0A1R3XWU7					Q7U117					Rv0912		Rv0912			
NC_002945.3	Mycobrowser_v4	CDS	951938	952381	.	+	0	Mb0877	Mb0877		conserved protein	Mb0877, -, len: 147 aa. Equivalent to Rv0854, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein, similar to several hypothetical protein from Mycobacterium leprae e.g. NP_301674.1|NC_002677 (144 aa); NP_302683.1|NC_002677|Z95398|MLCL622.27c (156 aa), FASTA scores: opt: 193, E(): 1.6e-06, (24.6% identity in 134 aa overlap); NP_301218.1|NC_002677 (146 aa); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 171, E(): 5.8e-05, (21.5% identity in 135 aa overlap). Also similar to SC6G10.02c|T35511|AL049497|SC6G10_2 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 344, E(): 6.1e- 17, (37.6% identity in 141 aa overlap). And similar to many proteins from Mycobacterium tuberculosis e.g. downstreams ORFs Rv0856 and Rv0857,etc.	Q7U139,A0A1R3XWM3	No	conserved hypotheticals			A0A1R3XWM3				IPR005031,IPR023393	Q7U139					Rv0854		Rv0854			
NC_002945.3	Mycobrowser_v4	CDS	953579	953983	.	+	0	Mb0879	Mb0879		CONSERVED HYPOTHETICAL PROTEIN	Mb0879, -, len: 134 aa. Equivalent to Rv0856, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Conserved hypothetical protein, showing weak similarity with NP_301674.1| (NC_002677) conserved hypothetical protein from Mycobacterium leprae (144 aa); and SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. neighbouring ORF downstream Rv0857 CONSERVED HYPOTHETICAL PROTEIN (126 aa),FASTA scores: E(): 7.4e-27, (62.0% identity in 100 aa overlap); neighbouring ORF Rv0854|MTV043_47 CONSERVED HYPOTHETICAL PROTEIN (147 aa), FASTA scores: E(): 1.6e-15,(36.6% identity in 123 aa overlap),MTCI28.04|Z97050|MTCI28_4 (184 aa), FASTA scores: opt: 127, E(): 0.036, (26.0% identity in 127 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 123, E(): 0.06, (26.4% identity in 125 aa overlap).	Q7U137,A0A1R3XWL4	No	conserved hypotheticals			A0A1R3XWL4				IPR005031	Q7U137					Rv0856		Rv0856			
NC_002945.3	Mycobrowser_v4	CDS	2005157	2005720	.	+	0	Mb1809	Mb1809		conserved protein	Mb1809, -, len: 187 aa. Equivalent to Rv1780, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Conserved hypothetical protein, equivalent to Q49881|ML1380|U00021_2 cosmid L247 from Mycobacterium leprae (187 aa), FASTA scores: opt: 1000, E(): 0, (82.4% identity in 187 aa overlap).	Q7TZJ9,A0A1R3Y1F0	No	conserved hypotheticals			A0A1R3Y1F0					Q7TZJ9					Rv1780		Rv1780			
NC_002945.3	Mycobrowser_v4	CDS	954011	954484	.	+	0	Mb0880	Mb0880		CONSERVED HYPOTHETICAL PROTEIN	Mb0880, -, len: 157 aa. Equivalent to Rv0857, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 157 aa overlap). Conserved hypothetical protein, showing weak similarity with SC6G10.02|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF Rv0856 (134 aa), FASTA scores: E(): 9.6e-28, (61.6% identity in 99 aa overlap); upstream ORF Rv0854 (147 aa), FASTA scores: E(): 2.8e-18, (42.7% identity in 117 aa overlap); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 122, E(): 0.031, (29.4% identity in 85 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 114, E(): 0.1, (30.9% identity in 55 aa overlap).	Q7U136,A0A1R3XWM9	No	conserved hypotheticals			A0A1R3XWM9				IPR019587,IPR023393	Q7U136					Rv0857		Rv0857			
NC_002945.3	Mycobrowser_v4	CDS	961043	963313	.	-	0	Mb0885c	Mb0885c		conserved protein	Mb0885c, -, len: 756 aa. Equivalent to Rv0862c,len: 756 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 756 aa overlap). Conserved hypothetical protein, equivalent to NP_302419.1|NC_002677 possible DNA-binding protein from Mycobacterium leprae (753 aa); and highly similar (except in C-terminus) to MLCB57.01|Z99494|T45333 hypothetical protein from Mycobacterium leprae (>577 aa, truncated), FASTA scores: opt: 3047, E(): 0, (78.9% identity in 578 aa overlap). Also similar in part to SCD12A.03c|AB93395.1|AL357524 hypothetical protein from Streptomyces coelicolor (867 aa).	Q7U131,A0A1R3XWQ0	No	conserved hypotheticals			A0A1R3XWQ0					Q7U131					Rv0862c		Rv0862c			
NC_002945.3	Mycobrowser_v4	CDS	1078830	1079126	.	+	0	Mb0993	Mb0993		conserved protein	Mb0993, -, len: 98 aa. Equivalent to Rv0968, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 98 aa overlap). Conserved hypothetical protein, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa).	X2BGN3,P64780	No	conserved hypotheticals			P64780					X2BGN3					Rv0968		Rv0968			
NC_002945.3	Mycobrowser_v4	CDS	967804	968193	.	-	0	Mb0894c	Mb0894c		POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0894c, -, len: 129 aa. Equivalent to Rv0870c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 129 aa overlap). Possible conserved integral membrane protein, highly similar to other membrane proteins: putative secreted proteins or hypothetical proteins e.g. CAC08263.1| AL392146 putative integral membrane protein from Streptomyces coelicolor (138 aa); NP_233433.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (143 aa); NP_455572.1|NC_003198 putative membrane protein from Salmonella enterica subsp. enterica serovar Typhi (148 aa); P37065|YCCF_ECOLI HYPOTHETICAL 16.3 KD PROTEIN from Escherichia coli (148 aa), FASTA scores: opt: 183, E(): 1.9e-06, (36.6% identity in 134 aa overlap); etc.	Q7U127,A0A1R3XYS0	No	cell wall and cell processes			A0A1R3XYS0				IPR005185	Q7U127					Rv0870c		Rv0870c			
NC_002945.3	Mycobrowser_v4	CDS	1027570	1028151	.	+	0	Mb0945	Mb0945		POSSIBLE RESOLVASE	Mb0945, -, len: 193 aa. Equivalent to Rv0921, len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 193 aa overlap). Possible resolvase for IS1535, highly similar to many bacterial resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 537, E(): 5.7e-29, (51.8% identity in 166 aa overlap). Presents an helix turn helix motif.	Q7U109,A0A1R3XXT1	No	insertion seqs and phages			A0A1R3XXT1				IPR006119	Q7U109					Rv0921		Rv0921			
NC_002945.3	Mycobrowser_v4	CDS	1185331	1186188	.	+	0	Mb1091	Mb1091		CONSERVED HYPOTHETICAL PROTEIN	Mb1091, -, len: 285 aa. Equivalent to Rv1062, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 285 aa overlap). Conserved hypothetical protein, some similarity to AL079356|SC6G9_10 hypothetical protein in Streptomyces coelicolor (289 aa), FASTA scores: opt: 556, E(): 1.2e-27, (39.0% identity in 287 aa overlap), and Z99111|BSUB0008_176 Bacillus subtilis (260 aa), FASTA scores: opt: 163, E(): 0.0013, (27.4% identity in 179aa overlap)	Q7U0R4,A0A1R3XX86	No	conserved hypotheticals			A0A1R3XX86				IPR002641,IPR016035	Q7U0R4					Rv1062		Rv1062			
NC_002945.3	Mycobrowser_v4	CDS	980971	981732	.	-	0	Mb0907c	Mb0907c		CONSERVED HYPOTHETICAL PROTEIN	Mb0907c, -, len: 253 aa. Equivalent to Rv0883c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 253 aa overlap). Conserved hypothetical protein, equivalent to O3306|MLCB57_16 CONSERVED HYPOTHETICAL PROTEI from Mycobacterium leprae (251 aa), FASTA scores: E(): 0, (79.4% identity in 253 aa overlap). Also highly similar to N_terminus of AL009204|SC9B10_22 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (352 aa), FASTA scores: E(): 6.1e-20, (35.0% identity in 246 aa overlap).	X2BGF0,P64740	No	conserved hypotheticals			P64740					X2BGF0					Rv0883c		Rv0883c			
NC_002945.3	Mycobrowser_v4	CDS	973012	974172	.	-	0	Mb0898c	Mb0898c		CONSERVED HYPOTHETICAL PROTEIN	Mb0898c, -, len: 386 aa. Equivalent to Rv0874c,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Conserved hypothetical protein, highly similar in part to SPU62616_1 hypothetical protein from Synechococcus sp. (280 aa),FASTA scores: E(): 6.3e-26, (35.2% identity in 264 aa overlap); SYCSLLLH_102 from Synechocystis sp. (447 aa),FASTA scores: E(): 1.1e-18, (29.5% identity in 400 aa overlap). Also highly similar to Rv0628c|MTCY20H10_9 from Mycobacterium tuberculosis (383 aa), FASTA scores: E():0,(81.5% identity in 383 aa overlap).	X2BG28,P0A5D4,P0A5D4	No	conserved hypotheticals			P0A5D4					X2BG28,P0A5D4					Rv0874c		Rv0874c			
NC_002945.3	Mycobrowser_v4	CDS	974272	974760	.	-	0	Mb0899c	Mb0899c		POSSIBLE CONSERVED EXPORTED PROTEIN	Mb0899c, -, len: 162 aa. Equivalent to Rv0875c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible conserved exported protein, equivalent to MLCB57_11|O33056 possible exported protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 789, E(): 0, (71.4% identity in 161 aa overlap).	X2BGA5,P64732	No	cell wall and cell processes			P64732					X2BGA5					Rv0875c		Rv0875c			
NC_002945.3	Mycobrowser_v4	CDS	974757	976403	.	-	0	Mb0900c	Mb0900c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0900c, -, len: 548 aa. Equivalent to Rv0876c,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Possible conserved transmembrane protein, equivalent to MLCB57_12|O33057 possible membrane protein from Mycobacterium leprae (579 aa), FASTA scores: opt: 2850, E(): 0, (81.0% identity in 568 aa overlap). Also highly similar (except in N-terminus) to CAB93403.1|AL357524 putative integral membrane protein from Streptomyces coelicolor (463 aa).	Q7U124,A0A1R3XWN3	No	cell wall and cell processes			A0A1R3XWN3				IPR011701,IPR016196	Q7U124					Rv0876c		Rv0876c			
NC_002945.3	Mycobrowser_v4	CDS	978946	979221	.	-	0	Mb0903c	Mb0903c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0903c, -, len: 91 aa. Equivalent to Rv0879c, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Possible conserved transmembrane protein, C-terminus highly similar to C-terminal part of MLCB57_14|O33059 conserved hypothetical protein from Mycobacterium leprae (91 aa), FASTA scores: E(): 1.2e-25, (76.9% identity in 91 aa overlap).	X2BG33,P64736,P64736	No	cell wall and cell processes			P64736					X2BG33,P64736					Rv0879c		Rv0879c			
NC_002945.3	Mycobrowser_v4	CDS	979399	979830	.	+	0	Mb0904	Mb0904		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY MARR-FAMILY)	Mb0904, -, len: 143 aa. Equivalent to Rv0880, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Possible transcriptional regulator, MarR family, equivalent to MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 818, E(): 0, (89.5% identity in 143 aa overlap). Also similar to many others e.g. CAB93410.1|AL357524 putative marR-family protein from Streptomyces coelicolor (145 aa); NP_251757.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (147 aa); etc. Also similar to Rv2327 from Mycobacterium tuberculosis (163 aa).	X2BGB0,P67746,P67746	No	regulatory proteins			P67746					X2BGB0,P67746					Rv0880		Rv0880			
NC_002945.3	Mycobrowser_v4	CDS	987698	989170	.	+	0	Mb0912	Mb0912		PROBABLE EXPORTED PROTEIN	Mb0912, -, len: 490 aa. Equivalent to Rv0888, len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 490 aa overlap). Probable exported protein. Equivalent to AAK45157.1 from Mycobacterium tuberculosis strain CDC1551 (507 aa) but shorter 17 aa. Contains possible N-terminal signal sequence.	X2BGF4,P64744,P64744	No	cell wall and cell processes			P64744					X2BGF4,P64744					Rv0888		Rv0888			
NC_002945.3	Mycobrowser_v4	CDS	979827	980693	.	+	0	Mb0905	Mb0905		POSSIBLE RRNA METHYLTRANSFERASE (RRNA METHYLASE)	Mb0905, -, len: 288 aa. Equivalent to Rv0881, len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 288 aa overlap). Possible rRNA methyltransferase (EC 2.1.1.-), highly similar to others and hypothetical proteins e.g. CAB76071.1|AL157953 putative rRNA methylase from Streptomyces coelicolor (272 aa); NP_421117.1|NC_002696 spoU rRNA methylase family protein from Caulobacter crescentus (268 aa); D90913_93|P74261 rRNA METHYLASE from Synechocystis sp. (274 aa), FASTA scores: E(): 1.1e-13, (26.3% identity in 278 aa overlap); P18644|TSNR_STRCN rRNA METHYLTRANSFERASE (EC 2.1.1.66) from Streptomyces cyaneus (Streptomyces curacoi) (269 aa), FASTA scores: E(): 3.7e-08, (23.9% identity in 268 aa overlap); etc. Equivalent to AAK45146.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 46 aa.	X2BGE2,P59968,P59968	No	intermediary metabolism and respiration			P59968					X2BGE2,P59968					Rv0881		Rv0881			
NC_002945.3	Mycobrowser_v4	CDS	980690	980974	.	+	0	Mb0906	Mb0906		PROBABLE TRANSMEMBRANE PROTEIN	Mb0906, -, len: 94 aa. Equivalent to Rv0882, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Probable transmembrane protein.	X2BGF8,P64738,P64738	No	cell wall and cell processes			P64738					X2BGF8,P64738					Rv0882		Rv0882			
NC_002945.3	Mycobrowser_v4	CDS	985978	986436	.	-	0	Mb0911c	Mb0911c		CONSERVED HYPOTHETICAL PROTEIN	Mb0911c, -, len: 152 aa. Equivalent to Rv0887c,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (194 aa), FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity in 131 aa overlap); etc. Also shows weak similarity with transposases and related proteins.	X2BGG3,P64742	No	conserved hypotheticals			P64742					X2BGG3					Rv0887c		Rv0887c			
NC_002945.3	Mycobrowser_v4	CDS	993063	993920	.	-	0	Mb0915c	Mb0915c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb0915c, -, len: 285 aa. Equivalent to Rv0891c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Possible transcriptional regulator, highly similar in N-terminus to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar to several Mycobacterium tuberculosis putative transcriptional regulators e.g. Q1102|MTCY02B10_22 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (1159 aa),FASTA scores: opt: 702, E(): 8.3e-40, (50.6% identity in 247 aa overlap); MTV036_21; MTV008_44; MTCY02B10_23. Also shows similarity with several adenylate cyclases and hydrolases from other organisms.	X2BGE9,P59970,P59970	No	regulatory proteins			P59970					X2BGE9,P59970					Rv0891c		Rv0891c			
NC_002945.3	Mycobrowser_v4	CDS	994318	995805	.	+	0	Mb0916	Mb0916		PROBABLE MONOOXYGENASE	Mb0916, -, len: 495 aa. Equivalent to Rv0892, len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Probable monooxygenase (EC 1.14.-.-), highly similar to others e.g. NP_250787.1|NC_002516 probable flavin-binding monooxygenase from Pseudomonas aeruginosa (491 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); P12015|CYMO_ACIS cyclohexanone monooxygenase from Acinetobacter sp. (542 aa), FASTA scores: opt: 489, E(): 6.8e-26, (30.3% identity in 492 aa overlap); etc. Also highly similar to Rv0565c, Rv3854c,Rv3083, etc from Mycobacterium tuberculosis. Has hydrophobic stretch at N-terminus.	X2BGG8,P64746,P64746	No	intermediary metabolism and respiration			P64746					X2BGG8,P64746					Rv0892		Rv0892			
NC_002945.3	Mycobrowser_v4	CDS	1173329	1174234	.	+	0	Mb1079	Mb1079		PROBABLE OXIDOREDUCTASE	Mb1079, -, len: 301 aa. Equivalent to Rv1050, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). Probable oxidoreductase (EC 1.-.-.-) similar to many e.g. Rv1543|MTCY48.22C|Q10783 PUTATIVE OXIDOREDUCTASE CY48.22C (341 aa), FASTA scores: opt: 462, E(): 3e-22, (33.6% identity in 265 aa overlap).	Q7U0S6,A0A1R3XX66	No	intermediary metabolism and respiration			A0A1R3XX66				IPR002198,IPR002347,IPR016040	Q7U0S6					Rv1050		Rv1050			
NC_002945.3	Mycobrowser_v4	CDS	1241558	1242256	.	+	0	Mb1145	Mb1145		POSSIBLE EXPORTED PROTEIN	Mb1145, -, len: 232 aa. Equivalent to Rv1115, len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 232 aa overlap). Possible exported protein, contains possible N-terminal signal sequence.	Q7U0M3,A0A1R3XXR8	No	cell wall and cell processes			A0A1R3XXR8				IPR000064	Q7U0M3					Rv1115		Rv1115			
NC_002945.3	Mycobrowser_v4	CDS	995783	996760	.	-	0	Mb0917c	Mb0917c		possible s-adenosylmethionine-dependent methyltransferase	Mb0917c, -, len: 325 aa. Equivalent to Rv0893c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 325 aa overlap). Conserved hypothetical protein, belongs in family with P96823|Rv0146|MTCI5.20 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 784, E(): 0, (43.2% identity in 308 aa overlap); Rv0726c,Rv0731c, Rv3399, etc. Also shows some similarity with others e.g. SC9B5.10|T35930 hypothetical protein from Streptomyces coelicolor (303 aa); BSUB0008_141|Q45500 HYPOTHETICAL 34.8 KD PROTEIN from Bacillus subtilis (304 aa), FASTA scores: E(): 0.00033, (26.8% identity in 168 aa overlap); etc.	X2BGF9,P64748,P64748	No	lipid metabolism			P64748					X2BGF9,P64748					Rv0893c		Rv0893c			
NC_002945.3	Mycobrowser_v4	CDS	996989	998170	.	+	0	Mb0918	Mb0918		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY LUXR-FAMILY)	Mb0918, -, len: 393 aa. Equivalent to Rv0894, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Possible regulatory protein, LuxR family, highly similar in part to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar to others e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); NP_107293.1|NC_002678 transcriptional regulator from Mesorhizobium loti (903 aa); etc. Also similar to other regulatory proteins from Mycobacterium tuberculosis e.g. Rv2488c|MTV008_44 (1137 aa), FASTA score: (53.2% identity in 363 aa overlap); Rv1358|MTCY02B10_22 (1159 aa), FASTA score: (52.3% identity in 365 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	X2BG43,P64750,P64750	No	regulatory proteins			P64750					X2BG43,P64750					Rv0894		Rv0894			
NC_002945.3	Mycobrowser_v4	CDS	2507582	2508037	.	-	0	Mb2278c	Mb2278c		Probable integral membrane protein	Mb2278c, -, len: 151 aa. Equivalent to Rv2254c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 151 aa overlap). Probable integral membrane protein.	Q7VEM8,A0A1R3Y0P4	No	cell wall and cell processes			A0A1R3Y0P4				IPR001123	Q7VEM8					Rv2254c		Rv2254c			
NC_002945.3	Mycobrowser_v4	CDS	998247	999764	.	+	0	Mb0919	Mb0919		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb0919, -, len: 505 aa. Equivalent to Rv0895, len: 505 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 505 aa overlap). Conserved hypothetical protein; member of family with: Rv3740c,Rv3734c, Rv1425, Rv1760, etc. Shows some similarity with NP_301898.1|NC_002677 conserved membrane protein from Mycobacterium leprae (491 aa).	X2BGC4,P67205,P67205	No	lipid metabolism			P67205					X2BGC4,P67205					Rv0895		Rv0895			
NC_002945.3	Mycobrowser_v4	CDS	1143118	1144095	.	+	0	Mb1049	Mb1049		conserved protein	Mb1049, -, len: 325 aa. Equivalent to Rv1021, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 325 aa overlap). Conserved hypothetical protein, similar to YBL1_STRCI|P33653 hypothetical 26.1 kd protein from Streptomyces cacaoi (242 aa), FASTA scores: opt: 493, E(): 1.1e-23, (42.9% identity in 238 aa overlap).	Q7U0U8,A0A1R3XX33	No	conserved hypotheticals			A0A1R3XX33				IPR004518	Q7U0U8					Rv1021		Rv1021			
NC_002945.3	Mycobrowser_v4	CDS	1001273	1002880	.	-	0	Mb0921c	Mb0921c		PROBABLE OXIDOREDUCTASE	Mb0921c, -, len: 535 aa. Equivalent to Rv0897c,len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 535 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases from diverse organisms e.g. CAB94055.1|AL358672 putative oxidoreductase from Streptomyces coelicolor (540 aa); NP_147877.1|NC_000854 phytoene dehydrogenase from Aeropyrum pernix (549 aa); Q01671|CRTD_RHOSH methoxyneurosporene dehydrogenase from Rhodobacter sphaeroides (495 aa), FASTA scores: opt: 139, E(): 2.6e-06, (23.8% identity in 538 aa overlap); etc. Also similar to Rv1432, Rv2997, and Rv3829c from Mycobacterium tuberculosis.	X2BGH3,P64752,P64752	No	intermediary metabolism and respiration			P64752					X2BGH3,P64752					Rv0897c		Rv0897c			
NC_002945.3	Mycobrowser_v4	CDS	1004270	1004422	.	+	0	Mb0924	Mb0924		POSSIBLE MEMBRANE PROTEIN	Mb0924, -, len: 50 aa. Equivalent to Rv0900, len: 50 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 50 aa overlap). Possible membrane protein,with hydrophobic domain from aa 4-26.	X2BGD0,P64756,P64756	No	cell wall and cell processes			P64756					X2BGD0,P64756					Rv0900		Rv0900			
NC_002945.3	Mycobrowser_v4	CDS	1004422	1004949	.	+	0	Mb0925	Mb0925		POSSIBLE CONSERVED EXPORTED OR MEMBRANE PROTEIN	Mb0925, -, len: 175 aa. Equivalent to Rv0901, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 175 aa overlap). Possible conserved exported or membrane protein, with hydrophobic N-terminus at aa 7-25. Shows some similarity in C-terminus to O33070|Z99494|MLCB57.59 HYPOTHETICAL PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 204,E(): 3.2e-12, (44.9% identity in 78 aa overlap)	X2BGG0,P64758,P64758	No	cell wall and cell processes			P64758					X2BGG0,P64758					Rv0901		Rv0901			
NC_002945.3	Mycobrowser_v4	CDS	1015864	1016637	.	+	0	Mb0935	Mb0935		conserved protein	Mb0935, -, len: 257 aa. Equivalent to Rv0911, len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Conserved hypothetical protein, showing similarity with hydroxylases and hypothetical proteins e.g. T35325 probable hydroxylase from Streptomyces coelicolor (265 aa); Q54242 hypothetical protein from Streptomyces, FASTA scores: opt: 372, E(): 8.8e-18, (32.0% identity in 256 aa overlap); AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV from Streptomyces peucetius (275 aa); AAA63051.1|U15184 hypothetical protein from Mycobacterium leprae (94 aa); etc. Also similar to Rv0577 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (261 aa).	Q7U118,A0A1R3XXS1	No	conserved hypotheticals			A0A1R3XXS1				IPR025870	Q7U118					Rv0911		Rv0911			
NC_002945.3	Mycobrowser_v4	CDS	1010650	1012200	.	+	0	Mb0931	Mb0931		conserved protein	Mb0931, -, len: 516 aa. Equivalent to Rv0907, len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 511 aa overlap). Conserved hypothetical protein, possibly involved in cell wall biosynthesis: similar to many beta-lactamases, penicillin-binding proteins and hypothetical proteins e.g. NP_298910.1|NC_002488 beta-lactamase from Xylella fastidiosa (455 aa); Q06317|PBP4_NOCLA PENICILLIN-BINDING PROTEIN 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E(): 8.8e-05, (28.7% identity in 401 aa overlap); etc. N-terminus highly similar to AAA63047.1|U15184 hypothetical protein from Mycobacterium leprae (58 aa). Related to other putative esterases and penicillin binding proteins in Mycobacterium tuberculosis e.g. Rv1730c|MTCY04C12.15c (517 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U121,A0A1R3XWT2	No	cell wall and cell processes			A0A1R3XWT2				IPR001466,IPR012338,IPR021860	Q7U121					Rv0907		Rv0907			
NC_002945.3	Mycobrowser_v4	CDS	1015147	1015326	.	+	0	Mb0933	Mb0933		CONSERVED HYPOTHETICAL PROTEIN	Mb0933, -, len: 59 aa. Equivalent to Rv0909, len: 59 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 59 aa overlap). Conserved hypothetical protein, equivalent to NP_302399.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (56 aa). Also some similarity with AL022268|SC4H2_10c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (97 aa), FASTA scores: opt: 106, E(): 0.13, (43.2% identity in 37 aa overlap).	Q7U120,A0A1R3XWT0	No	conserved hypotheticals			A0A1R3XWT0				IPR028037	Q7U120					Rv0909		Rv0909			
NC_002945.3	Mycobrowser_v4	CDS	1025963	1027282	.	-	0	Mb0944c	Mb0944c		probable transposase	Mb0944c, -, len: 439 aa. Equivalent to Rv0920c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Probable transposase for IS1554, highly similar to others e.g. MTCY441.35|Q45111 transposase from Mycobacterium tuberculosis (419 aa), FASTA scores: opt: 1113, E(): 0,(43.9% identity in 378 aa overlap); etc. Contains transposases mutator family signature (PS01007).	Q7U110,A0A1R3XYX4	No	insertion seqs and phages			A0A1R3XYX4				IPR001207	Q7U110					Rv0920c		Rv0920c			
NC_002945.3	Mycobrowser_v4	CDS	1147466	1148425	.	+	0	Mb1054	Mb1054		conserved protein	Mb1054, -, len: 319 aa. Equivalent to Rv1026, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 319 aa overlap). Conserved hypothetical protein. Equivalent to AL023514|MLCB4.02 hypothetical protein from Mycobacterium leprae (317 aa) (77.9% identity in 321 aa overlap). Similar to GPPA_ECOLI|P25552 guanosine-5'-triphosphate, 3'-diphosphate pyrophoshatase from Escherichia coli (494 aa), FASTA scores: opt: 281,E(): 3.2e-11, (30.6% identity in 291 aa overlap).	Q7U0U3,A0A1R3XY40	No	virulence, detoxification, adaptation			A0A1R3XY40				IPR003695	Q7U0U3					Rv1026		Rv1026			
NC_002945.3	Mycobrowser_v4	CDS	1017683	1019191	.	-	0	Mb0937c	Mb0937c		POSSIBLE DIOXYGENASE	Mb0937c, -, len: 502 aa. Equivalent to Rv0913c,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 502 aa overlap). Possible dioxygenase (EC 1.-.-.-), showing similarity with others e.g. AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage dioxygenase from Phaseolus vulgaris (543 aa); CAB56138.1|AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); AAK06796.1|AF324838_15|AF324838 putative dioxygenase SimC5 from Streptomyces antibioticus (456 aa); Q53353|S65040 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE (EC 1.13.11.43) from Pseudomonas paucimobilis (485 aa), FASTA scores: opt: 310,E(): 3.4e-20, (28.9% identity in 495 aa overlap); etc. Also some similarity with Rv0654|MTCI376.22 PROBABLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa).	Q7U116,A0A1R3XX62	No	intermediary metabolism and respiration			A0A1R3XX62				IPR004294	Q7U116					Rv0913c		Rv0913c			
NC_002945.3	Mycobrowser_v4	CDS	1019193	1020431	.	-	0	Mb0938c	Mb0938c		POSSIBLE LIPID CARRIER PROTEIN OR KETO ACYL-COA THIOLASE	Mb0938c, -, len: 412 aa. Equivalent to Rv0914c,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 412 aa overlap). Possible lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16), highly similar to NP_421905.1|NC_002696 thiolase family protein from Caulobacter crescentus (407 aa); and similar to others e.g. NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase from Mesorhizobium loti (392 aa); NP_385796.1|NC_003047 PUTATIVE 3-KETOACYL-COA THIOLASE PROTEIN from Sinorhizobium meliloti (389 aa); NP_275932.1|NC_000916 lipid-transfer protein (sterol or nonspecific) from Methanothermobacter thermautotrophicus (383 aa); AB55378.1|AL117263 possible 3-ketoacyl-CoA thiolase from Leishmania major (441 aa), FASTA scores: opt: 547, E(): 3.1e-26, (31.0% identity in 435 aa overlap); etc. Also similar to Rv2790c, Rv1627c, Rv0244, etc from Mycobacterium tuberculosis. COULD BELONG TO THE THIOLASE FAMILY.	Q7U115,A0A1R3XWT3	No	lipid metabolism			A0A1R3XWT3				IPR002155,IPR016038,IPR016039,IPR020616,IPR020617	Q7U115					Rv0914c		Rv0914c			
NC_002945.3	Mycobrowser_v4	CDS	1024677	1025153	.	+	0	Mb0942	Mb0942		conserved protein	Mb0942, -, len: 158 aa. Equivalent to Rv0918, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 158 aa overlap). Conserved hypothetical protein, similar in part to Q50116 hypothetical protein from Mycobacterium leprae (44 aa), FASTA scores: opt: 132,E(): 0.0055, (65.6% identity in 32 aa overlap). Also some similarity in C-terminus with other hypothetical proteins e.g. NP_289961.1|NC_002655 hypothetical protein from Escherichia coli strain O157:H7 (94 aa); etc.	Q7U112,A0A1R3XWU5	No	conserved hypotheticals			A0A1R3XWU5				IPR010985,IPR014795,IPR016547	Q7U112					Rv0918		Rv0918			
NC_002945.3	Mycobrowser_v4	CDS	1025150	1025650	.	+	0	Mb0943	Mb0943		gcn5-related n-acetyltransferase	Mb0943, -, len: 166 aa. Equivalent to Rv0919, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 166 aa overlap). Conserved hypothetical protein, some similarity to Q50115 hypothetical protein from Mycobacterium leprae (90 aa), FASTA scores: opt: 243,E(): 5.3e-11, (56.5% identity in 85 aa overlap).	Q7U111,A0A1R3XWU2	No	intermediary metabolism and respiration			A0A1R3XWU2				IPR000182,IPR016181	Q7U111					Rv0919		Rv0919			
NC_002945.3	Mycobrowser_v4	CDS	1028151	1029803	.	+	0	Mb0946	Mb0946		possible transposase	Mb0946, -, len: 550 aa. Equivalent to Rv0922, len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 550 aa overlap). Possible transposase for IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa), FASTA scores: opt 939, E(): 0,(40.6% identity in 465 aa overlap); etc.	Q7U108,A0A1R3XWV7	No	insertion seqs and phages			A0A1R3XWV7				IPR001959	Q7U108					Rv0922		Rv0922			
NC_002945.3	Mycobrowser_v4	CDS	1029979	1031043	.	-	0	Mb0947c	Mb0947c		CONSERVED HYPOTHETICAL PROTEIN	Mb0947c, -, len: 354 aa. Equivalent to Rv0923c,len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Conserved hypothetical protein, showing similarity with C-terminal part of AF034138|AF034138_7|yjoB HYPOTHETICAL PROTEIN from Bacillus subtilis (200 aa), FASTA scores: opt: 193, E(): 4.2e-05, (32.3% identity in 167 aa overlap).	Q7U107,A0A1R3XX69	No	conserved hypotheticals			A0A1R3XX69				IPR008585,IPR013024,IPR017939	Q7U107					Rv0923c		Rv0923c			
NC_002945.3	Mycobrowser_v4	CDS	1033175	1034251	.	-	0	Mb0949c	Mb0949c		CONSERVED HYPOTHETICAL PROTEIN	Mb0949c, -, len: 358 aa. Equivalent to Rv0926c,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 358 aa overlap). Conserved hypothetical protein, similar to Rv1059 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (354 aa). Also shows some similarity to AF170923|AF170923_3 dihydrodipicolinate reductase from Mastigocladus laminosus (278 aa), FASTA scores: opt: 170, E(): 0.00088, (25.7% identity in 276 aa overlap).	Q7U105,A0A1R3XWU8	No	conserved hypotheticals			A0A1R3XWU8				IPR000846,IPR016040	Q7U105					Rv0926c		Rv0926c			
NC_002945.3	Mycobrowser_v4	CDS	1034305	1035096	.	-	0	Mb0950c	Mb0950c		probable short-chain type dehydrogenase/reductase	Mb0950c, -, len: 263 aa. Equivalent to Rv0927c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 263 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, notably 7-alpha-hydroxysteroid dehydrogenases and glucose 1-dehydrogenases e.g. P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 551,E(): 1e-26, (39.5% identity in 248 aa overlap); NP_252778.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa); etc. Also similar to other dehydrogenases from Mycobacterium tuberculosis e.g. MTCY09F9.36, E():1.4e-18; MTCY369.14, E():8e-17; MTCY02B10.14, E():2.5e-14; MTCY09F9.23c, E():1.5e-13; MTCY03C7.07, E():1.9e-13. Contains PS00061 Short-chain dehydrogenases/reductases family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7U104,A0A1R3XWT1	No	intermediary metabolism and respiration			A0A1R3XWT1				IPR002198,IPR002347,IPR016040,IPR020904	Q7U104					Rv0927c		Rv0927c			
NC_002945.3	Mycobrowser_v4	CDS	1066517	1067884	.	+	0	Mb0980	Mb0980		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0980, -, len: 455 aa. Equivalent to Rv0955, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 455 aa overlap). Probable conserved integral membrane protein, highly similar to AL035500|MLCL373_6 putative membrane protein from Mycobacterium leprae (430 aa), FASTA score: (75.9% identity in 419 aa overlap); and AAL05878.1|AF411607_2|AF411607 unknown protein from Mycobacterium avium subsp. paratuberculosis (409 aa).	X2BGM3,P64772,P64772	No	cell wall and cell processes			P64772					X2BGM3,P64772					Rv0955		Rv0955			
NC_002945.3	Mycobrowser_v4	CDS	1112835	1113911	.	+	0	Mb1023	Mb1023		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb1023, -, len: 358 aa. Equivalent to Rv0996, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 358 aa overlap). Probable conserved transmembrane protein, equivalent to AL035500|MLCL373_25 putative membrane protein from Mycobacterium leprae (342 aa), FASTA scores: (66.4% identity in 360 aa overlap). Contains possible signal sequence and other hydrophobic domains.	Q7U0W0,A0A1R3XZ60	No	cell wall and cell processes			A0A1R3XZ60					Q7U0W0					Rv0996		Rv0996			
NC_002945.3	Mycobrowser_v4	CDS	1048879	1050813	.	+	0	Mb0964	Mb0964		POSSIBLE BIFUNCTIONAL ENZYME: 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE) + CYCLASE/DEHYDRASE	Mb0964, -, len: 644 aa. Equivalent to Rv0939, len: 644 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 644 aa overlap). Possible bifunctional enzyme, including 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase activity (EC 5.3.3.-), and cyclase/dehydrase activity (EC undetermined). N-terminal part similar to many isomerases e.g. NP_343861.1|NC_002754 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Sulfolobus solfataricus (318 aa); NP_068932.1|NC_000917 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Archaeoglobus fulgidus (324 aa),FASTA scores: opt: 400, E(): 5.8e-15, (33.9% identity in 289 aa overlap); etc. And C-terminal part highly similar to many cyclases/dehydrases e.g. AAK61721.1|AY033994 cyclase-like protein from Streptomyces aureofaciens (305 aa); CAC44204.1|AL593842 cyclase from Streptomyces coelicolor (297 aa), FASTA scores: opt: 375, E(): 2.7e-26,(35.6% identity in 284 aa overlap); NP_343860.1|NC_002754 putative Cyclase/dehydrase from Sulfolobus solfataricus (308 aa); etc. Also similar to Rv2993c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis.	Q7U0Z6,A0A1R3XYZ6	No	intermediary metabolism and respiration			A0A1R3XYZ6				IPR001279,IPR002529,IPR011234	Q7U0Z6					Rv0939		Rv0939			
NC_002945.3	Mycobrowser_v4	CDS	1051060	1051926	.	-	0	Mb0965c	Mb0965c		POSSIBLE OXIDOREDUCTASE	Mb0965c, -, len: 288 aa. Equivalent to Rv0940c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 288 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); AAG52987.1|AF040570|Rif17 putative alkanal monooxygenase from Amycolatopsis mediterranei (356 aa); etc. Also similar to putative oxidoreductases from Mycobacterium tuberculosis such as Rv0953c|P71557|YT21_MYCTU (282 aa), FASTA scores: opt: 311, E(): 3.7e-08, (31.0% identity in 248 aa overlap),Rv3079c (275 aa), Rv0791c (347 aa), etc.	X2BGL1,P64762,P64762	No	intermediary metabolism and respiration			P64762					X2BGL1,P64762					Rv0940c		Rv0940c			
NC_002945.3	Mycobrowser_v4	CDS	1053163	1054203	.	-	0	Mb0968c	Mb0968c		PROBABLE MONOOXYGENASE	Mb0968c, -, len: 346 aa. Equivalent to Rv0943c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 346 aa overlap). Possible monooxygenase (EC 1.-.-.-), similar in part to others e.g. NP_250229.1|NC_002516 probable flavin-containing monooxygenase from Pseudomonas aeruginosa (527 aa); AAC36351.1|AF090329 cyclohexanone monooxygenase homolog from Pseudomonas fluorescens (437 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); etc. Also similar to putative monooxygenases from Mycobacterium tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa). FASTA scores: opt: 129, E(): 8.5e-21, (27.5% identity in 236 aa overlap); Rv0892 (495 aa); Rv3049c (524 aa); etc.	X2BG95,P64766	No	intermediary metabolism and respiration			P64766					X2BG95					Rv0943c		Rv0943c			
NC_002945.3	Mycobrowser_v4	CDS	1054232	1054708	.	+	0	Mb0969	Mb0969		POSSIBLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FAPY-DNA GLYCOSYLASE)	Mb0969, -, len: 158 aa. Equivalent to Rv0944, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 158 aa overlap). Possible formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), similar to C-terminus of formamidopyrimidine-DNA glycosylases e.g. CAB63194.1|AL133469 putative formamidopyrimidine-DNA glycosylase from Streptomyces coelicolor (287 aa); FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) from Lactococcus lactis subsp. lactis (273 aa), FASTA scores: opt: 246, E(): 2.4e-09,(28.9% identity in 142 aa overlap); O50606|FPG_THETH|MUTM|FPG FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Thermus thermophilus (267 aa); etc. Also similar to C-termini of endonucleases or DNA glycosylases of Mycobacterium tuberculosis e.g. Rv3297, Rv2464c,Rv2924c. MAY BE BELONG TO THE FPG FAMILY.	Q7U0Z4,A0A1R3XWW9	No	information pathways			A0A1R3XWW9				IPR000214,IPR010663,IPR010979,IPR015886	Q7U0Z4					Rv0944		Rv0944			
NC_002945.3	Mycobrowser_v4	CDS	1054714	1055475	.	+	0	Mb0970	Mb0970		probable short-chain type dehydrogenase/reductase	Mb0970, -, len: 253 aa. Equivalent to Rv0945, len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 253 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_346338.1|NC_003028 oxidoreductase (short chain dehydrogenase/reductase family) from Streptococcus pneumoniae (253 aa); AAB70845.1|AF019986|PksB from Dictyostelium discoideum (260 aa); AAF86624.1|U87786 clavaldehyde dehydrogenase from Streptomyces clavuligerus (247 aa); P37440|UCPA_ECOLI oxidoreductase from Escherichia coli (285 aa), FASTA scores: opt: 275, E(): 1.1e-12, (33.8% identity in 201 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7U0Z3,A0A1R3XWU9	No	intermediary metabolism and respiration			A0A1R3XWU9				IPR002198,IPR002347,IPR016040,IPR020904	Q7U0Z3					Rv0945		Rv0945			
NC_002945.3	Mycobrowser_v4	CDS	1057767	1057997	.	-	0	Mb0972c	Mb0972c		probable mycolyl transferase, pseudogene	Mb0972c, -, len: 76 aa. Equivalent to Rv0947c, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 76 aa overlap). Probable mycolyl transferase pseudogene (EC 2.-.-.-), similar to part of P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c) (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 213, E(): 2e-08,(69.6% identity in 46 aa overlap).		No	lipid metabolism													Rv0947c		Rv0947c			
NC_002945.3	Mycobrowser_v4	CDS	1065566	1066477	.	+	0	Mb0979	Mb0979		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0979, -, len: 303 aa. Equivalent to Rv0954, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 303 aa overlap). Probable conserved transmembrane protein, highly similar to 34KD_MYCPA|Q04959 34 kd antigenic protein from Mycobacterium paratuberculosis (298 aa), FASTA scores: opt: 1023, E(): 7.2e-36, (59.3% identity in 305 aa overlap); AAC69251.1|U82111 34 kDa antigen precursor from Mycobacterium leprae (336 aa); and AL035500|MLCL373.06 hypothetical membrane protein from Mycobacterium leprae (297 aa), FASTA score: (55.6% identity in 315 aa overlap).	X2BGJ1,P65638,P65638	No	cell wall and cell processes			P65638					X2BGJ1,P65638					Rv0954		Rv0954			
NC_002945.3	Mycobrowser_v4	CDS	1061123	1062121	.	-	0	Mb0975c	Mb0975c		CONSERVED HYPOTHETICAL PROTEIN	Mb0975c, -, len: 332 aa. Equivalent to Rv0950c,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 332 aa overlap). Conserved hypothetical protein, highly similar to AL035500|MLCL373.02c|T45433 hypothetical protein from Mycobacterium leprae (343 aa),FASTA scores: opt: 1500, E(): 0, (71.0% identity in 331 aa overlap). C-terminus highly similar to part of various proteins e.g. C-terminal part of NP_441943.1|NC_000911|NlpD lipoprotein from Synechocystis sp (715 aa); N-terminal part of NP_066789.1|NC_002576 putative peptidase from Rhodococcus equi (546 aa); C-terminal part of NP_212396.1|NC_001318 conserved hypothetical protein from Borrelia burgdorferi (417 aa); C-terminal part of P33648|NLPD_ECOLI|nlpd lipoprotein from Escherichia coli (379 aa), FASTA scores: opt: 276, E(): 2e-10, (29.9% identity in 234 aa overlap); etc.	Q7U0Z2,A0A1R3XXW1	No	conserved hypotheticals			A0A1R3XXW1				IPR011055,IPR016047	Q7U0Z2					Rv0950c		Rv0950c			
NC_002945.3	Mycobrowser_v4	CDS	1187883	1188449	.	+	0	Mb1094	Mb1094		CONSERVED HYPOTHETICAL PROTEIN	Mb1094, -, len: 188 aa. Equivalent to Rv1065, len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 188 aa overlap). Conserved hypothetical protein, some similarity to AL0209|SC4H8_11 hypothetical protein from Streptomyces coelicolor (182 aa), FASTA scores: opt: 156, E(): 0.0011, (31.3% identity in 195 aa overlap).	Q7U0R3,A0A1R3XY76	No	conserved hypotheticals			A0A1R3XY76				IPR010300,IPR011051,IPR014710	Q7U0R3					Rv1065		Rv1065			
NC_002945.3	Mycobrowser_v4	CDS	1064553	1065401	.	-	0	Mb0978c	Mb0978c		POSSIBLE OXIDOREDUCTASE	Mb0978c, -, len: 282 aa. Equivalent to Rv0953c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 282 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to CAA48222.1|X68102 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (166 aa). Similar to several hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); NP_070025.1|NC_000917 N5,N10-methylenetetrahydromethanopterin reductase (mer-2) from Archaeoglobus fulgidus (348 aa); etc. Also similar to several hypothetical proteins and oxidoreductases from Mycobacterium tuberculosis e.g. Rv2161c|O06216|Z95388|MTCY270.07 (288 aa), FASTA scores: opt: 633, E(): 0, (40.4% identity in 277 aa overlap),Rv3079c (275 aa), Rv0791c (347 aa), etc. Contains PS00201 Flavodoxin signature.	X2BGA8,P64770,P64770	No	intermediary metabolism and respiration			P64770					X2BGA8,P64770					Rv0953c		Rv0953c			
NC_002945.3	Mycobrowser_v4	CDS	1070322	1071701	.	+	0	Mb0983	Mb0983		POSSIBLE MAGNESIUM CHELATASE	Mb0983, -, len: 459 aa. Equivalent to Rv0958, len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 459 aa overlap). Possible magnesium chelatase (EC 4.99.1.-), similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148,E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA MAGNESIUM-CHELATASE SUBUNIT CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase (EC 4.99.1.-) chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)	Q7U0Y8,A0A1R3XWY0	No	intermediary metabolism and respiration			A0A1R3XWY0				IPR002078,IPR027417	Q7U0Y8					Rv0958		Rv0958			
NC_002945.3	Mycobrowser_v4	CDS	1071694	1073712	.	+	0	Mb0984	Mb0984		CONSERVED HYPOTHETICAL PROTEIN	Mb0984, -, len: 672 aa. Equivalent to Rv0959, len: 672 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 672 aa overlap). Conserved hypothetical protein, similar to AE002069|AE002069_12 hypothetical protein from Deinococcus radiodurans (403 aa), FASTA scores: opt: 395, E(): 1.3e-15, (26.8% identity in 426 aa overlap). Contains a single copy at the N-terminus of a short repeat found three times in the M. tuberculosis ORF O33341|MTV003.05c|AL008883.	X2BGJ9,P0A5D8	No	conserved hypotheticals			P0A5D8					X2BGJ9					Rv0959		Rv0959			
NC_002945.3	Mycobrowser_v4	CDS	1074513	1074860	.	+	0	Mb0986	Mb0986		PROBABLE INTEGRAL MEMBRANE PROTEIN	Mb0986, -, len: 115 aa. Equivalent to Rv0961, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Probable integral membrane protein.	X2BGN7,P64776,P64776	No	cell wall and cell processes			P64776					X2BGN7,P64776					Rv0961		Rv0961			
NC_002945.3	Mycobrowser_v4	CDS	1075736	1076536	.	-	0	Mb0988c	Mb0988c		CONSERVED HYPOTHETICAL PROTEIN	Mb0988c, -, len: 266 aa. Equivalent to Rv0963c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 266 aa overlap). Conserved hypothetical protein, similar in part to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: E(): 1.2e-23,(39.0% identity in 254 aa overlap); Rv2542 (403 aa); Rv2079 (656 aa). Also similar in part to AL133423|SC4A7_3 HYPOTHETICAL SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FASTA scores: opt: 231, E(): 6.8e-07, (31.4% identity in 204 aa overlap); and SCH10.21c|T36533 hypothetical protein from Streptomyces coelicolor (329 aa).	X2BGL0,P64778	No	conserved hypotheticals			P64778					X2BGL0					Rv0963c		Rv0963c			
NC_002945.3	Mycobrowser_v4	CDS	1077217	1077636	.	-	0	Mb0990c	Mb0990c		CONSERVED HYPOTHETICAL PROTEIN	Mb0990c, -, len: 139 aa. Equivalent to Rv0965c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 139 aa overlap). Conserved hypothetical protein, showing weak similarity with Rv2798c|MTCY16B7.45 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (108 aa), FASTA scores: E(): 5.6e-12, (38.9% identity in 90 aa overlap). Equivalent to AAK45242.1 from Mycobacterium tuberculosis strain CDC1551 (146 aa) but shorter 7 aa.	Q7U0Y7,A0A1R3XWZ5	No	conserved hypotheticals			A0A1R3XWZ5					Q7U0Y7					Rv0965c		Rv0965c			
NC_002945.3	Mycobrowser_v4	CDS	1077672	1078274	.	-	0	Mb0991c	Mb0991c		conserved protein	Mb0991c, -, len: 200 aa. Equivalent to Rv0966c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 200 aa overlap). Conserved hypothetical protein, equivalent to AL035500|MLCL373_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (200 aa),FASTA scores: opt: 1080, E(): 0, (79.5% identity in 200 aa overlap). Also highly similar to SCE6.30c|CAB88834.1|AL353832 hypothetical protein from Streptomyces coelicolor (277 aa). Some similarity to Rv2862c|MTV007.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (194 aa), FASTA scores: E(): 3.1e-06, (31.5% identity in 184 aa overlap). Equivalent to AAK45243.1 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 30 aa. Note that Rv0966c has been shortened since first entry.	Q7U0Y6,A0A1R3XWZ1	No	conserved hypotheticals			A0A1R3XWZ1				IPR012551	Q7U0Y6					Rv0966c		Rv0966c			
NC_002945.3	Mycobrowser_v4	CDS	1114312	1114563	.	+	0	Mb1023A	Mb1023A		HYPOTHETICAL PROTEIN	Mb1023A, -, len: 83 aa. Equivalent to hypothetical protein MT1025.2 from Mycobacterium tuberculosis strain CDC1551, (100% identity with 83 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al.,2013). Mb1023A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BGU3,A0A1R3XY17	No				A0A1R3XY17					X2BGU3										
NC_002945.3	Mycobrowser_v4	CDS	1081491	1082123	.	+	0	Mb0995	Mb0995		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb0995, -, len: 210 aa. Equivalent to Rv0970, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Probable conserved integral membrane protein, equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa).	X2BGU9,P64782,P64782	No	cell wall and cell processes			P64782					X2BGU9,P64782					Rv0970		Rv0970			
NC_002945.3	Mycobrowser_v4	CDS	1088931	1090613	.	-	0	Mb1001c	Mb1001c		CONSERVED HYPOTHETICAL PROTEIN	Mb1001c, -, len: 560 aa. Equivalent to Rv0976c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 560 aa overlap). Conserved hypothetical protein, highly similar to others e.g. CAB95890.1|AL359988 conserved hypothetical protein from Streptomyces coelicolor (558 aa); P_251576.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (600 aa); etc. N-terminal part highly similar to AL035500|MLCL373_14 probable pseudogene from Mycobacterium leprae (163 aa),FASTA score: (50.0% identity in 122 aa overlap).	Q7TVC1,A0A1R3XX00	No	conserved hypotheticals			A0A1R3XX00				IPR010839	Q7TVC1					Rv0976c		Rv0976c			
NC_002945.3	Mycobrowser_v4	CDS	1095121	1095315	.	-	0	Mb1004c	Mb1004c		HYPOTHETICAL PROTEIN	Mb1004c, -, len: 64 aa. Equivalent to Rv0979c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 64 aa overlap). Hypothetical unknown protein. Start codon changed since first submission (-44 aa)	Q7U0X6,A0A1R3XXZ6	No	conserved hypotheticals			A0A1R3XXZ6					Q7U0X6					Rv0979c		Rv0979c			
NC_002945.3	Mycobrowser_v4	CDS	1114744	1115175	.	+	0	Mb1024	Mb1024		HYPOTHETICAL PROTEIN	Mb1024, -, len: 143 aa. Equivalent to Rv0997, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 143 aa overlap). Hypothetical unknown protein, equivalent to AAK45276.1 from Mycobacterium tuberculosis strain CDC1551 (87 aa) but longer 56 aa.	Q7U0V9,A0A1R3XX36	No	conserved hypotheticals			A0A1R3XX36					Q7U0V9					Rv0997		Rv0997			
NC_002945.3	Mycobrowser_v4	CDS	1242486	1242761	.	-	0	Mb1147c	Mb1147c		CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT)	Mb1147c, -, len: 91 aa. Equivalent to Rv1116A, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 91 aa overlap). Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of Rv1646|Z85982_9 from Mycobacterium tuberculosis (310 aa),FASTA scores: opt: 301, E(): 9.3e-13, (68.05% identity in 72 aa overlap). Also overlaps gene on other strand,Rv1116, at 3'-end.	Q7U0M1,A0A1R3XXE2	No	conserved hypotheticals			A0A1R3XXE2					Q7U0M1					Rv1116A		Rv1116A			
NC_002945.3	Mycobrowser_v4	CDS	2063545	2064288	.	+	0	Mb1859	Mb1859		conserved protein	Mb1859, -, len: 247 aa. Equivalent to Rv1828, len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Conserved hypothetical protein, equivalent to O32918|MLCB1788.35c|AL008609 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1397,E(): 0, (87.6% identity in 251 aa overlap).	X2BJ64,P67670,P67670	No	conserved hypotheticals			P67670					X2BJ64,P67670					Rv1828		Rv1828			
NC_002945.3	Mycobrowser_v4	CDS	1109029	1109622	.	-	0	Mb1019c	Mb1019c		CONSERVED HYPOTHETICAL PROTEIN	Mb1019c, -, len: 197 aa. Equivalent to Rv0992c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Conserved hypothetical protein, equivalent to NP_301256.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (197 aa). Also similar, except in N-terminus, to other hypothetical proteins and ligases e.g. SCE87.34|CAB59679.1|AL132674 hypothetical protein from Streptomyces coelicolor (204 aa); NP_461977.1|NC_003197 putative ligase from Salmonella typhimurium (182 aa); P09160|YGFA_ECOLI HYPOTHETICAL 21.1 kDa PROTEIN from Escherichia coli (182 aa), FASTA scores: opt: 191, E(): 1.1e-09, (29.5% identity in 146 aa overlap); etc.	Q7U0W4,A0A1R3XX02	No	conserved hypotheticals			A0A1R3XX02				IPR002698,IPR024185	Q7U0W4					Rv0992c		Rv0992c			
NC_002945.3	Mycobrowser_v4	CDS	1102254	1103000	.	+	0	Mb1012	Mb1012		PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1012, -, len: 248 aa. Equivalent to Rv0986, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 248 aa overlap). Probable ATP-binding protein ABC transporter supposed involved in transport of adhesion component (see citation below), highly similar to many ATP-binding proteins e.g. AE0010|AE001033_8 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 669, E(): 0, (45.7% identity in 219 aa overlap); CAB81857.1|AL161691 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa); X84019|ZMDNAGRP_4 glutamate uptake regulatory protein (grp) from Z.mobilis (232 aa), FASTA score: (44.4% identity in 225 aa overlap); Z99111|BSUB0008_108 from Bacillus subtilis (230 aa), FASTA score: (38.7% identity in 222 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7U0X1,A0A1R3XX09	No	cell wall and cell processes			A0A1R3XX09				IPR003439,IPR003593,IPR017871,IPR027417	Q7U0X1					Rv0986		Rv0986			
NC_002945.3	Mycobrowser_v4	CDS	1115199	1116200	.	+	0	Mb1025	Mb1025		CONSERVED HYPOTHETICAL PROTEIN	Mb1025, -, len: 333 aa. Equivalent to Rv0998, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 333 aa overlap). Conserved hypothetical protein, possibly cyclic nucleotide-dependent protein kinase (EC 2.7.-.-), highly similar to NP_301261.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (353 aa); and AL035500|MLCL373.38|T45457 hypothetical protein from Mycobacterium leprae (143 aa), FASTA score: (61.5% identity in 143 aa overlap). Also similar to many hypothetical proteins and cyclic-NMP-dependent protein kinases (generally at C-terminus) e.g. N-terminus of SC9B10.09|T35878 hypothetical protein from Streptomyces coelicolor (1039 aa); P05987|KAPR_DICDI CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN (EC 2.7.1.37) from Dictyostelium discoideum (327 aa), FASTA scores: opt: 177,E(): 0.00036, (32.0% identity in 122 aa overlap); NP_104403.1|NC_002678 hypothetical protein (contains similarity to cAMP-dependent protein kinase regulatory subunit) from Mesorhizobium loti (151 aa); etc. Contains PS00889 Cyclic nucleotide-binding domain signature 2.	Q7U0V8,A0A1R3XXE5	No	conserved hypotheticals			A0A1R3XXE5				IPR000182,IPR000595,IPR014710,IPR016181,IPR018488,IPR018490	Q7U0V8					Rv0998		Rv0998			
NC_002945.3	Mycobrowser_v4	CDS	1102993	1104264	.	+	0	Mb1013	Mb1013		PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER	Mb1013, -, len: 423 aa. Equivalent to 5' end of Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 423 aa overlap). Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below),whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265,E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014.	Q7U0X0,A0A1R3XZ45	No				A0A1R3XZ45				IPR003838,IPR025857	Q7U0X0										
NC_002945.3	Mycobrowser_v4	CDS	1121340	1122599	.	-	0	Mb1031c	Mb1031c		PROBABLE MEMBRANE PROTEIN	Mb1031c, -, len: 419 aa. Equivalent to Rv1004c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 419 aa overlap). Probable membrane protein. Contains repetitive sequences, which have similarities with elastin, and possible N-terminal signal sequence.	Q7U0V4,A0A1R3XX29	No	cell wall and cell processes			A0A1R3XX29					Q7U0V4					Rv1004c		Rv1004c			
NC_002945.3	Mycobrowser_v4	CDS	1104265	1105560	.	+	0	Mb1014	Mb1014		PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER	Mb1014, -, len: 431 aa. Equivalent to 3' end of Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 431 aa overlap). Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below),whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265,E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 into two parts, Mb1013 and Mb1014.	Q7U0W9,A0A1R3XY07	No				A0A1R3XY07				IPR003838,IPR025857	Q7U0W9										
NC_002945.3	Mycobrowser_v4	CDS	1124165	1125868	.	+	0	Mb1033	Mb1033		unknown protein	Mb1033, -, len: 567 aa. Equivalent to Rv1006, len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 567 aa overlap). Hypothetical unknown protein.	Q7U0V3,A0A1R3XY25	No	conserved hypotheticals			A0A1R3XY25				IPR017853	Q7U0V3					Rv1006		Rv1006			
NC_002945.3	Mycobrowser_v4	CDS	1105567	1106727	.	+	0	Mb1015	Mb1015		POSSIBLE CONSERVED EXPORTED PROTEIN	Mb1015, -, len: 386 aa. Equivalent to Rv0988, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 386 aa overlap). Possible conserved exported protein, with potential N-terminal signal sequence, similar (except in N-terminus) to O32737|L63540 ATTH PROTEIN from Agrobacterium tumefaciens (355 aa),FASTA scores: opt: 651, E(): 5.7e-33, (33.4% identity in 344 aa overlap); and NP_231265.1|NC_002505 conserved hypothetical protein from Vibrio cholerae (372 aa).	Q7U0W8,A0A1R3XX28	No	cell wall and cell processes			A0A1R3XX28				IPR010791,IPR023374	Q7U0W8					Rv0988		Rv0988			
NC_002945.3	Mycobrowser_v4	CDS	1168121	1169002	.	+	0	Mb1074	Mb1074		HYPOTHETICAL PROTEIN	Mb1074, -, len: 293 aa. Equivalent to Rv1045, len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 293 aa overlap). Hypothetical unknown protein.	Q7U0T0,A0A1R3XY56	No	conserved hypotheticals			A0A1R3XY56				IPR014942	Q7U0T0					Rv1045		Rv1045			
NC_002945.3	Mycobrowser_v4	CDS	1165539	1165946	.	-	0	Mb1071c	Mb1071c		probable is like-2 transposase	Mb1071c, -, len: 135 aa. Equivalent to Rv1042c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 135 aa overlap). Probable IS like-2 transposase, similar to Q50761 TRANSPOSASE from Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1149.	Q7U0T3,A0A1R3XX71	No	insertion seqs and phages			A0A1R3XX71				IPR025161	Q7U0T3					Rv1042c		Rv1042c			
NC_002945.3	Mycobrowser_v4	CDS	1116982	1117599	.	-	0	Mb1027c	Mb1027c		CONSERVED HYPOTHETICAL PROTEIN	Mb1027c, -, len: 205 aa. Equivalent to Rv1000c,len: 205 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 205 aa overlap). Conserved hypothetical protein, equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from Streptomyces coelicolor (210 aa), FASTA scores: E(): 2.1e-45, (56.8% identity); 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein described as DNA repair system specific for alkylated DNA from Xylella fastidiosa (200 aa), FASTA scores: E(): 3.4e-14, (38.55% identity); and similar in C-terminus to other hypothetical proteins. Note that replaces original Rv1000 predicted on other strand.	Q7U0V6,A0A1R3XX27	No	conserved hypotheticals			A0A1R3XX27				IPR005123,IPR027450	Q7U0V6					Rv1000c		Rv1000c			
NC_002945.3	Mycobrowser_v4	CDS	1118879	1120390	.	-	0	Mb1029c	Mb1029c		CONSERVED MEMBRANE PROTEIN	Mb1029c, -, len: 503 aa. Equivalent to Rv1002c,len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 503 aa overlap). Conserved membrane protein. Similar to AL132674|SCE87.05 hypothetical protein from Streptomyces coelicolor (591 aa), FASTA scores: opt: 666, E(): 0, (39.0% identity in 546 aa overlap); weakly similar to TSCC_PSEAM|P55019 thiazide-sensitive sodium-chloride cotransporter from Pseudopleuronectes americanus (1023 aa), FASTA scores: opt: 44, E(): 4.2e-06,(22.4% identity in 326 aa overlap).	Q7U0V5,A0A1R3XX38	No	cell wall and cell processes			A0A1R3XX38				IPR003342,IPR027005	Q7U0V5					Rv1002c		Rv1002c			
NC_002945.3	Mycobrowser_v4	CDS	1120473	1121330	.	+	0	Mb1030	Mb1030		conserved protein	Mb1030, -, len: 285 aa. Equivalent to Rv1003, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 285 aa overlap). Conserved hypothetical protein, similar to others e.g. AL132674|SCE87.04 Streptomyces coelicolor (286 aa), FASTA scores: opt: 877,E(): 0, (53.2% identity in 280 aa overlap); and YRAL_ECOLI|P45528 hypothetical 31.3 kd protein (286 aa),FASTA scores: opt: 561, E(): 4.4e-27, (36.9% identity in 279 aa overlap).	X2BGS7,P0A641,P0A641	No	conserved hypotheticals			P0A641					X2BGS7,P0A641					Rv1003		Rv1003			
NC_002945.3	Mycobrowser_v4	CDS	1169084	1169677	.	-	0	Mb1075c	Mb1075c		HYPOTHETICAL PROTEIN	Mb1075c, -, len: 197 aa. Equivalent to Rv1046c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 174 aa overlap). Hypothetical unknown protein. Start changed since first submission (-65 aa).	Q7U0S9,A0A1R3XX92	No	unknown			A0A1R3XX92					Q7U0S9					Rv1046c		Rv1046c			
NC_002945.3	Mycobrowser_v4	CDS	1576898	1577380	.	+	0	Mb1439	Mb1439		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1439, -, len: 160 aa. Equivalent to Rv1404, len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 160 aa overlap). Probable transcriptional regulatory protein, some similarity to MARR_ECOLI|P27245 multiple antibiotic resistance protein from Escherichia coli (125 aa), FASTA scores: opt: 136,E(): 0.004, (35.1% identity in 74 aa overlap).	Q7U045,A0A1R3XY87	No	regulatory proteins			A0A1R3XY87				IPR000835,IPR011991,IPR023187	Q7U045					Rv1404		Rv1404			
NC_002945.3	Mycobrowser_v4	CDS	1131559	1131873	.	+	0	Mb1040	Mb1040		HYPOTHETICAL PROTEIN	Mb1040, -, len: 104 aa. Equivalent to the 3' end of Rv1012, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv, (98.4% identity in 63 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a different NH2 terminus.	Q7U0V2,A0A1R3XX48	No				A0A1R3XX48					Q7U0V2										
NC_002945.3	Mycobrowser_v4	CDS	1169872	1171119	.	+	0	Mb1076	Mb1076		probable transposase	Mb1076, -, len: 415 aa. Equivalent to Rv1047, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). IS1081 transposase,most similar to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa), FASTA scores: opt: 2675, E(): 0, (99.8% identity in 415 aa overlap). Contains PS01007 Transposases, Mutator family, signature	X2BGW7,P60231,P60231	No	insertion seqs and phages			P60231					X2BGW7,P60231					Rv1047		Rv1047			
NC_002945.3	Mycobrowser_v4	CDS	1165019	1165570	.	-	0	Mb1070c	Mb1070c		probable is like-2 transposase	Mb1070c, -, len: 183 aa. Equivalent to Rv1041c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 183 aa overlap). Probable IS like-2 transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (186 aa), FASTA scores: opt: 173, E(): 0.00016, (40.9% identity in 176 aa overlap). Similar to Rv1150, C-terminal part of transposase of putative Mycobacterium tuberculosis IS like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with respect to Mycobacterium tuberculosis Q50761 transposase,the 10G2 cosmid sequence appears to be correct.		No	insertion seqs and phages													Rv1041c		Rv1041c			
NC_002945.3	Mycobrowser_v4	CDS	1138762	1139355	.	+	0	Mb1047	Mb1047		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb1047, -, len: 197 aa. Equivalent to Rv1019, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 197 aa overlap). Probable transcriptional regulator, similar to many memebers of the tetR family e.g. MTCY7D11.18c (34.4% identity in 189 aa overlap). Helix turn helix motif from aa 27-48 (+5.42 SD).	Q7U0U9,A0A1R3XX46	No	regulatory proteins			A0A1R3XX46				IPR001647,IPR009057,IPR011075,IPR015893,IPR023772	Q7U0U9					Rv1019		Rv1019			
NC_002945.3	Mycobrowser_v4	CDS	1159822	1160508	.	-	0	Mb1064c	Mb1064c		PROBABLE TRANSPOSASE (FRAGMENT)	Mb1064c, -, len: 228 aa. Equivalent to Rv1035c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Probable IS1560 transposase fragment, similar to parts of Rv3387|E1202305|MTV004.45 (225 aa) (47.8% identity in 67 aa overlap) and Rv3386|E1202304|MTV004.44 (234 aa) (55.1% identity in 127 aa overlap).	Q7U0T7,A0A1R3XY47	No	insertion seqs and phages			A0A1R3XY47					Q7U0T7					Rv1035c		Rv1035c			
NC_002945.3	Mycobrowser_v4	CDS	1160542	1160880	.	-	0	Mb1065c	Mb1065c		PROBABLE IS1560 TRANSPOSASE (FRAGMENT)	Mb1065c, -, len: 112 aa. Equivalent to Rv1036c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 112 aa overlap). Probable IS1560 transposase fragment, similar to part of Rv3386|E1202304|MTV004.44 (234 aa) (82.8% identity in 87 aa overlap).	Q7U0T6,A0A1R3XX81	No	insertion seqs and phages			A0A1R3XX81					Q7U0T6					Rv1036c		Rv1036c			
NC_002945.3	Mycobrowser_v4	CDS	1166229	1167254	.	-	0	Mb1072c	Mb1072c		CONSERVED HYPOTHETICAL PROTEIN	Mb1072c, -, len: 341 aa. Equivalent to Rv1043c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 341 aa overlap). Conserved hypothetical protein similar to AL096872|SC5F7.08 PUTATIVE LIPOATE-PROTEIN LIGASE from Streptomyces coelicolor (362 aa), FASTA scores: opt: 206, E(): 1.4e-05, (30.3% identity in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU HYPOTHETICAL PROTEASE from Bacillus subtitis (400 aa),FASTA scores: opt: 159, E(): 0.013, (27.1% identity in 210 aa overlap).	Q7U0T2,A0A1R3XX73	No	conserved hypotheticals			A0A1R3XX73				IPR009003	Q7U0T2					Rv1043c		Rv1043c			
NC_002945.3	Mycobrowser_v4	CDS	3068374	3068841	.	+	0	Mb2826	Mb2826		CONSERVED HYPOTHETICAL PROTEIN	Mb2826, -, len: 155 aa. Equivalent to Rv2803, len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 155 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from other organisms, and with some similarity to C-terminal part of Rv0918|Z95210_12 hypothetical protein from Mycobacterium tuberculosis (158 aa), FASTA scores: opt: 204, E(): 9e-07, (42.35% identity in 85 aa overlap). Replaces original 2803c on other strand.	Q7TXU2	No	conserved hypotheticals							IPR010985,IPR014795,IPR016547	Q7TXU2	A0A1R3Y477				Rv2803		Rv2803			
NC_002945.3	Mycobrowser_v4	CDS	1177376	1177690	.	+	0	Mb1083	Mb1083		probable integrase (fragment)	Mb1083, -, len: 104 aa. Equivalent to Rv1054, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable integrase (fragment), similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 273, E(): 8.8e-13, (64.7% identity in 68 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa), FASTA scores: opt: 105, E(): 0.9, (31.8% identity in 85 aaoverlap). This ORF continues in another frame as Rv1055|MTV017.08 but no error can be found to account for frameshift. Length extended since first submission (+36 aa).	Q7U0S2,A0A1R3XZC2	No	insertion seqs and phages			A0A1R3XZC2				IPR011010,IPR013762,IPR014417	Q7U0S2					Rv1054		Rv1054			
NC_002945.3	Mycobrowser_v4	CDS	1177687	1177821	.	+	0	Mb1084	Mb1084		POSSIBLE INTEGRASE (FRAGMENT)	Mb1084, -, len: 44 aa. Equivalent to Rv1055, len: 44 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 44 aa overlap). Possible integrase (fragment); first 49 aa similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 291, E(): 2.2e-16, (74.3% identity in 70 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa),FASTA scores: opt: 146, E(): 8.3e-05, (52.1% identity in 48 aa overlap); and to many other integrases or transposases. Shortened since first submission (-34 aa).	Q7U0S1,A0A1R3XY66	No	insertion seqs and phages			A0A1R3XY66					Q7U0S1					Rv1055		Rv1055			
NC_002945.3	Mycobrowser_v4	CDS	1178076	1178840	.	+	0	Mb1085	Mb1085		conserved protein	Mb1085, -, len: 254 aa. Equivalent to Rv1056, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 254 aa overlap). Conserved hypothetical protein, some similarity in C-terminal region of Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126 aa), FASTA scores: opt: 254, E(): 1.2e-10, (43.4% identity in 106 aa overlap); and to Rv1670. C-terminal region is similar to AL035569|SC8D9.02 hypothetical protein from Streptomyces coelicolor (113 aa), FASTA scores: opt: 282,E(): 4.5e-12, (48.0% identity in 100 aa overlap).	Q7U0S0,A0A1R3XX99	No	conserved hypotheticals			A0A1R3XX99				IPR007361	Q7U0S0					Rv1056		Rv1056			
NC_002945.3	Mycobrowser_v4	CDS	1188446	1188841	.	+	0	Mb1095	Mb1095		CONSERVED HYPOTHETICAL PROTEIN	Mb1095, -, len: 131 aa. Equivalent to Rv1066, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 131 aa overlap). Conserved hypothetical protein, strong similarity to AL0209|SC4H8.10 hypothetical protein from Streptomyces coelicolor (132 aa), FASTA scores: opt: 429, E(): 5.2e-23, (57.1% identity in 119 aa overlap).	Q7U0R2,A0A1R3XXA5	No	conserved hypotheticals			A0A1R3XXA5				IPR001763	Q7U0R2					Rv1066		Rv1066			
NC_002945.3	Mycobrowser_v4	CDS	1179844	1181025	.	+	0	Mb1086	Mb1086		CONSERVED HYPOTHETICAL PROTEIN	Mb1086, -, len: 393 aa. Equivalent to Rv1057, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Conserved hypothetical protein, some similarity to X84710|MMSAG_1 surface antigen of Methanosarcina mazeii (491 aa), FASTA scores: opt: 363,E():6.2e-15, (31.3% identity in 294 aa overlap).	Q7U0R9,A0A1R3XXK8	No	conserved hypotheticals			A0A1R3XXK8				IPR011048,IPR015943	Q7U0R9					Rv1057		Rv1057			
NC_002945.3	Mycobrowser_v4	CDS	2064407	2064901	.	+	0	Mb1860	Mb1860		conserved protein	Mb1860, -, len: 164 aa. Equivalent to Rv1829, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Conserved hypothetical protein, equivalent to O32917|MLCB1788.34|AL008609 Hypothetical protein from Mycobacterium leprae (164 aa),FASTA scores: opt: 1011, E(): 0, (95.1% identity in 164 aa overlap). Also present in Aquifex aeolicus, etc.	Q7TZG7,A0A1R3Y1L8	No	conserved hypotheticals			A0A1R3Y1L8				IPR002714,IPR003729	Q7TZG7					Rv1829		Rv1829			
NC_002945.3	Mycobrowser_v4	CDS	1182839	1183903	.	+	0	Mb1088	Mb1088		conserved protein	Mb1088, -, len: 354 aa. Equivalent to Rv1059, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Conserved hypothetical protein, similar to Rv0926c|MTCY21C12.20c hypothetical protein from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 338, E(): 1.4e-14, (33.1% identity in 363 aa overlap).	Q7U0R7,A0A1R3XX84	No	conserved hypotheticals			A0A1R3XX84				IPR000846,IPR016040	Q7U0R7					Rv1059		Rv1059			
NC_002945.3	Mycobrowser_v4	CDS	1183956	1184429	.	+	0	Mb1089	Mb1089		unknown protein	Mb1089, -, len: 157 aa. Equivalent to Rv1060, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 157 aa overlap). Hypothetical unknown protein.	Q7U0R6,A0A1R3XX78	No	conserved hypotheticals			A0A1R3XX78				IPR019587,IPR023393	Q7U0R6					Rv1060		Rv1060			
NC_002945.3	Mycobrowser_v4	CDS	1186189	1187271	.	-	0	Mb1092c	Mb1092c		CONSERVED HYPOTHETICAL PROTEIN	Mb1092c, -, len: 360 aa. Equivalent to Rv1063c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Conserved hypothetical protein, similar to P37053|YCHK_ECOLI hypothetical protein from Escherichia coli (314 aa), FASTA scores: opt: 487,E(): 7.2e-23, (32.7% identity in 321 aa overlap). Also partially similar to Rv3239c|MTCY20B11.14c. BELONGS TO THE UPF0028 (SWS) FAMILY.	X2BGK7,P67099,P67099	No	conserved hypotheticals			P67099					X2BGK7,P67099					Rv1063c		Rv1063c			
NC_002945.3	Mycobrowser_v4	CDS	1193870	1195633	.	-	0	Mb1098c	Mb1098c		conserved protein	Mb1098c, -, len: 587 aa. Equivalent to Rv1069c,len: 587 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 587 aa overlap). Conserved hypothetical protein, hydrophobic regions in N-terminal domain. Similar in part to O07136|B1306.04C B1306.04c protein from Mycobacterium leprae (89 aa), FASTA scores: opt: 229, E(): 1.3e-07, (54.2% identity in 72 aa overlap).	Q7U0Q9,A0A1R3XX94	No	conserved hypotheticals			A0A1R3XX94				IPR012037,IPR027787,IPR027788	Q7U0Q9					Rv1069c		Rv1069c			
NC_002945.3	Mycobrowser_v4	CDS	1197639	1198475	.	+	0	Mb1101	Mb1101		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb1101, -, len: 278 aa. Equivalent to Rv1072, len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 278 aa overlap). Probable conserved transmembrane protein, equivalent to O07139|B1306.07|Y13803 Protein B1306.07 from Mycobacterium leprae (220 aa), FASTA scores: opt:1032, E(): 0, (75.0% identity in 220 aa overlap); and at the C-terminal end to Q50056|U1740D Mycobacterium leprae (96 aa), FASTA scores: opt: 381, E(): 1.2e-18, (71.6% identity in 81 aa overlap). Similar to Q54192|M80628|STMBLDA_1 TRANSFER RNA-LEU (BLDA) GENE AND ORF from Streptomyces griseus (293 aa), FASTA scores: opt:558, E(): 4.7e-30, (41.5% identity in 299 aa overlap). TBparse score is 0.896.	Q7U0Q7,A0A1R3XX96	No	cell wall and cell processes			A0A1R3XX96				IPR010539	Q7U0Q7					Rv1072		Rv1072			
NC_002945.3	Mycobrowser_v4	CDS	1198591	1199442	.	+	0	Mb1102	Mb1102		CONSERVED HYPOTHETICAL PROTEIN	Mb1102, -, len: 283 aa. Equivalent to Rv1073, len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 283 aa overlap). Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03 Mycobacterium tuberculosis (339 aa), FASTA scores: opt: 810, E(): 0,(47.4% identity in 272 aa overlap); Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289 aa), FASTA scores: opt: 704, E(): 0, (44.4% identity in 259 aa overlap); and Rv3517, etc., and GIR10|AF002133_10 M. avium strain GIR10 (346 aa), FASTA scores: opt: 802,E(): 0, (48.1% identity in 270 aa overlap).	Q7U0Q6,A0A1R3XX98	No	conserved hypotheticals			A0A1R3XX98					Q7U0Q6					Rv1073		Rv1073			
NC_002945.3	Mycobrowser_v4	CDS	1200786	1201730	.	-	0	Mb1104c	Mb1104c		CONSERVED EXPORTED PROTEIN	Mb1104c, -, len: 314 aa. Equivalent to Rv1075c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 314 aa overlap). Possibly exported protein, as it contains a N-terminal signal sequence,hydrophobic domain from aa 7-25. Similar to U15183|MLU15183_2 Mycobacterium leprae cosmid B1740 (106 aa), FASTA scores: opt: 207, E(): 1.6e-06, (42.6% identity in 101 aa overlap). Also weak similarity to many glyceraldehyde-3-phosphate dehydrogenases e.g. Q41595|G3PC_TAXBA Taxus baccata (340 aa), FASTA scores: opt: 147, E(): 0.027, (27.5% identity in 189 aa overlap).	Q7U0Q4,A0A1R3XY90	No	cell wall and cell processes			A0A1R3XY90				IPR013831	Q7U0Q4					Rv1075c		Rv1075c			
NC_002945.3	Mycobrowser_v4	CDS	1207344	1207778	.	-	0	Mb1110c	Mb1110c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb1110c, -, len: 144 aa. Equivalent to Rv1081c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Probable conserved membrane protein, with hydrophobic stretch from aa 26 -48, highly similar to NP_302548.1|NC_002677 conserved membrane protein from Mycobacterium leprae.	Q7U0Q1,A0A1R3XXC1	No	cell wall and cell processes			A0A1R3XXC1				IPR025443	Q7U0Q1					Rv1081c		Rv1081c			
NC_002945.3	Mycobrowser_v4	CDS	3134974	3135828	.	-	0	Mb2892c	Mb2892c		gcn5-related n-acetyltransferase	Mb2892c, -, len: 284 aa. Equivalent to Rv2867c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Conserved hypothetical protein, similar to Q9KYR8|SC5H4.21 HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces coelicolor (287 aa), FASTA scores: opt: 798, E(): 2.4e-45, (47.95% identity in 269 aa overlap).	Q7TXN7	No	intermediary metabolism and respiration							IPR000182,IPR013653,IPR016181,IPR016794,IPR025289	Q7TXN7	A0A1R3Y2G3				Rv2867c		Rv2867c			
NC_002945.3	Mycobrowser_v4	CDS	1208996	1211017	.	+	0	Mb1113	Mb1113		conserved protein	Mb1113, -, len: 673 aa. Equivalent to Rv1084, len: 673 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 673 aa overlap). Conserved hypothetical protein, similar to P37512|YYAL_BACSU hypothetical protein from Bacillus subtilis (689 aa), FASTA scores: opt: 1063,E(): 0, (36.5% identity in 696 aa overlap); AE0009|AE000983_10 Archaeoglobus fulgidus section 1 (642 aa), FASTA scores: opt: 1018, E(): 0, (37.2% identity in 600 aa overlap). Also similar to AE001938|AE001938_9 Deinococcus radiodurans (690 aa), FASTA scores: opt: 1097,E(): 0, (41.6% identity in 694 aa overlap).	Q7U0P9,A0A1R3XZF1	No	conserved hypotheticals			A0A1R3XZF1				IPR004879,IPR008928,IPR012336,IPR012341,IPR024705	Q7U0P9					Rv1084		Rv1084			
NC_002945.3	Mycobrowser_v4	CDS	1211116	1211844	.	-	0	Mb1114c	Mb1114c		POSSIBLE HEMOLYSIN-LIKE PROTEIN	Mb1114c, -, len: 242 aa. Equivalent to Rv1085c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 242 aa overlap). Possible hemolysin-like protein, integral membrane protein, similar to many hemolysins, and hypothetical proteins e.g. U28375|ECU28375_49 Hypothetical protein from Escherichia coli (219 aa), FASTA scores: opt: 308, E(): 7.5e-15,(30.6% identity in 180 aa overlap); AE0011|HIAE001124_2 Hypothetical protein from Borrelia burgdorferi (233 aa),FASTA scores: opt: 305, E(): 1.3e-14, (25.6% identity in 203 aa overlap). Also weakly similar to HLY3_BACCE|P54176 haemolysin from Bacillus cereus (219 aa), FASTA scores: opt: 247, E(): 8.7e-12, (27.5% identity in 171 aa overlap). Also similar to AE002027|AE002027_8 probable hemolysin from Deinococcus radiodurans (219 aa), FASTA scores: opt: 354, E(): 1.8e-16, (31.1% identity in 219 aa overlap).	X2BH03,P67158,P67158	No	virulence, detoxification, adaptation			P67158					X2BH03,P67158					Rv1085c		Rv1085c			
NC_002945.3	Mycobrowser_v4	CDS	1211955	1212743	.	+	0	Mb1115	Mb1115		SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) (Z-FPP SYNTHETASE) (Z-FARNESYL DIPHOSPHATE SYNTHETASE) (GERANYLTRANSTRANSFERASE) (FARNESYL PYROPHOSPHATE SYNTHETASE)	Mb1115, -, len: 262 aa. Equivalent to Rv1086, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 262 aa overlap). Short (C15) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.10) (see citations below), equivalent to NP_302598.1|NC_002677 possible undecaprenyl pyrophosphate synthetase from Mycobacterium leprae (262 aa), similar to many hypothetical proteins and several potential members of the upp synthase family e.g. NP_296167.1|NC_001263 undecaprenyl diphosphate synthase from Deinococcus radiodurans (339 aa); P20182|YT14_STRFR Hypothetical protein from Streptomyces fradiae (259 aa), FASTA scores: opt: 840, E(): 0, (51.0% identity in 259 aa overlap); and P38118|YARF_CORGL Hypothetical protein from Corynebacterium glutamicicum (234 aa), FASTA scores: opt: 729, E(): 0, (56.0% identity in 209 aa overlap); etc. Also similar to Rv2361c|MTCY27.19 (296 aa) (35.6% identity in 233 aa overlap). Contains PS01066 Uncharacterized protein family UPF0015 signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY.	X2BH82,Q7U0P8,Q7U0P8	No	cell wall and cell processes			Q7U0P8					X2BH82,Q7U0P8					Rv1086		Rv1086			
NC_002945.3	Mycobrowser_v4	CDS	1225757	1226632	.	+	0	Mb1126	Mb1126		POSSIBLE GLYCOSYL HYDROLASE	Mb1126, -, len: 291 aa. Equivalent to Rv1096, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 291 aa overlap). Possible glycosyl hydrolase (EC 3.-.-.-), possibly a deacetylase or esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3% identity in 289 aa overlap). Similar at the C-terminus of enzymes involved in carbohydrate degradation including Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog yjeA from Bacillus subtilis (467 aa), FASTA scores: opt: 418, E(): 2.6e-17, (38.6% identity in 184 aa overlap); M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces lividans (335 aa), FASTA scores: opt: 371, E(): 1.1e-14, (31.6% identity in 237 aa overlap); NP_345933.1|NC_003028 peptidoglycan N-acetylglucosamine deacetylase A from Streptococcus pneumoniae (463 aa); etc. Has possible N-terminal signal sequence with TMhelix at aa 13-31.	Q7U0N8,A0A1R3XXC7	No	intermediary metabolism and respiration			A0A1R3XXC7				IPR002509,IPR011330	Q7U0N8					Rv1096		Rv1096			
NC_002945.3	Mycobrowser_v4	CDS	1226635	1227516	.	-	0	Mb1127c	Mb1127c		PROBABLE MEMBRANE GLYCINE AND PROLINE RICH PROTEIN	Mb1127c, -, len: 293 aa. Equivalent to Rv1097c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 293 aa overlap). Probable membrane Gly-, Pro-rich protein, similar to Mycobacterium tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA scores: opt: 219, E(): 0.023, (30.5% identity in 266 aa overlap); and Rv2507. Contains potential membrane spanning region (aa ~68-92). TBparse score is 0.912.	Q7U0N7,A0A1R3XXC2	No	cell wall and cell processes			A0A1R3XXC2					Q7U0N7					Rv1097c		Rv1097c			
NC_002945.3	Mycobrowser_v4	CDS	1230763	1231791	.	-	0	Mb1131c	Mb1131c		CONSERVED MEMBRANE PROTEIN	Mb1131c, -, len: 342 aa. Equivalent to 3' end of Rv1101c, len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 342 aa overlap). Conserved membrane protein, shows some similarity to other bacterial proteins e.g. P77406|PERM_ECOLI PUTATIVE PERMEASE PERM from Escherichia coli (353 aa), FASTA scores: opt: 287, E(): 8.8e-12, (24.9% identity in 349 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U0N3,A0A1R3XXD0	No				A0A1R3XXD0				IPR002549	Q7U0N3										
NC_002945.3	Mycobrowser_v4	CDS	1232672	1233361	.	+	0	Mb1134	Mb1134		POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	Mb1134, -, len: 229 aa. Equivalent to Rv1104, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 229 aa overlap). Possible para-nitrobenzyl esterase (fragment; possibly first part) (EC 3.1.1.-). Similar to the N-terminal domain of many e.g. P37967|PNBA_BACSU Bacillus subtilis (489 aa), FASTA scores: opt: 715, E(): 0, (53.4% identity in 191 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing in MTV017.58|Rv1105.	Q7U0N0,A0A1R3XXE4	No	intermediary metabolism and respiration			A0A1R3XXE4				IPR002018	Q7U0N0					Rv1104		Rv1104			
NC_002945.3	Mycobrowser_v4	CDS	1233682	1234197	.	+	0	Mb1135	Mb1135		POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	Mb1135, -, len: 171 aa. Equivalent to Rv1105, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Possible para-nitrobenzyl esterase (fragment; possibly second part) (EC 3.1.1.-). Similar to C-terminal domain of many e.g. P71048 PARA-NITROBENZYL ESTERASE from Bacillus subtilis (489 aa), FASTA scores: opt: 248, E(): 2.7e-10, (32.3% identity in 167 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing from MTV017.57|Rv1104. Start changed since first submission.	Q7U0M9,A0A1R3XXQ8	No	intermediary metabolism and respiration			A0A1R3XXQ8				IPR002018	Q7U0M9					Rv1105		Rv1105			
NC_002945.3	Mycobrowser_v4	CDS	2065193	2065870	.	+	0	Mb1861	Mb1861		CONSERVED HYPOTHETICAL PROTEIN	Mb1861, -, len: 225 aa. Equivalent to Rv1830, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein MLCB1788.33c|AL008609|O32916 (231 aa), FASTA scores: opt: 1307, E(): 0, (89.6% identity in 231 aa overlap).	X2BJB4,P67672,P67672	No	conserved hypotheticals			P67672					X2BJB4,P67672					Rv1830		Rv1830			
NC_002945.3	Mycobrowser_v4	CDS	1238580	1239563	.	-	0	Mb1141c	Mb1141c		CONSERVED HYPOTHETICAL PROTEIN	Mb1141c, -, len: 327 aa. Equivalent to Rv1111c,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 327 aa overlap). Conserved hypothetical protein, N-terminal domain is hydrophobic, C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission.	Q7U0M6,A0A1R3XXE0	No	conserved hypotheticals			A0A1R3XXE0					Q7U0M6					Rv1111c		Rv1111c			
NC_002945.3	Mycobrowser_v4	CDS	1234215	1235327	.	-	0	Mb1136c	Mb1136c		3-beta-hydroxysteroid dehydrogenase	Mb1136c, -, len: 370 aa. Equivalent to Rv1106c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 370 aa overlap). Probable cholesterol dehydrogenase (EC 1.1.1.-). Equivalent to AL049491|MLCB1222_7 Mycobacterium leprae (376 aa ) (75.5% identity in 375 aa overlap). Highly similar to Q03704 NAD(P)-dependent cholesterol dehydrogenase from Nocardia sp. (364 aa), FASTA scores: opt: 1789, E(): 0, (74.5% identity in 361 aa overlap). Also similar to U32426|MCU32426_1 3-beta-hydroxy-Delta5-steroid dehydrogenase from Molluscum contagiosum virus (354 aa),FASTA scores: opt: 432, E(): 1.7e-22, (34.6% identity in 347 aa overlap). Also similar to series of Mycobacterium tuberculosis hypothetical proteins described as sugar epimerases or dehydratases e.g. Rv3634c, Rv3784, Rv3464,etc.	Q7U0M8,A0A1R3XXD8	No	intermediary metabolism and respiration			A0A1R3XXD8				IPR002225,IPR016040	Q7U0M8					Rv1106c		Rv1106c			
NC_002945.3	Mycobrowser_v4	CDS	1236828	1237466	.	-	0	Mb1139c	Mb1139c		conserved protein	Mb1139c, -, len: 212 aa. Equivalent to Rv1109c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 212 aa overlap). Conserved hypothetical protein, N-terminal domain is hydrophobic, C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. TBparse score is 0.934.	Q7U0M7,A0A1R3XXE9	No	conserved hypotheticals			A0A1R3XXE9					Q7U0M7					Rv1109c		Rv1109c			
NC_002945.3	Mycobrowser_v4	CDS	1239626	1240699	.	+	0	Mb1142	Mb1142		Probable GTP binding protein	Mb1142, -, len: 357 aa. Equivalent to Rv1112, len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 357 aa overlap). Probable GTP binding protein, similar to YCHF_HAEIN|P44681 probable gtp-binding protein (362 aa), FASTA scores: opt: 1189, E(): 0, (52.7% identity in 357 aa overlap). Equivalent to AL049491|MLCB1222_1 hypothetical protein from Mycobacterium leprae (356 aa) (85.9% identity in 354 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7VEZ6,A0A1R3XZH6	No	conserved hypotheticals			A0A1R3XZH6				IPR004396,IPR006073,IPR012675,IPR012676,IPR013029,IPR023192,IPR027417	Q7VEZ6					Rv1112		Rv1112			
NC_002945.3	Mycobrowser_v4	CDS	1244381	1244875	.	-	0	Mb1151c	Mb1151c		CONSERVED HYPOTHETICAL PROTEIN	Mb1151c, -, len: 164 aa. Equivalent to Rv1120c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Conserved hypothetical protein, some similarity at C-terminus to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1890c|MTCY180.28 (462 aa), FASTA scores: opt: 187, E(): 2.2e-05, (36.6% identity in 93 aa overlap) and Rv2488c|YZ19_MYCTU|Q10551 (285 aa), FASTA scores: opt: 156, E(): 0.00074, (32.7% identity in 107 aa overlap).	Q7U0L8,A0A1R3XXF0	No	conserved hypotheticals			A0A1R3XXF0				IPR001054	Q7U0L8					Rv1120c		Rv1120c			
NC_002945.3	Mycobrowser_v4	CDS	1252988	1254343	.	-	0	Mb1159c	Mb1159c		CONSERVED HYPOTHETICAL PROTEIN	Mb1159c, -, len: 451 aa. Equivalent to Rv1128c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 451 aa overlap). Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc.	Q7U0L1,A0A1R3XXG5	No	insertion seqs and phages			A0A1R3XXG5				IPR003615,IPR003870	Q7U0L1					Rv1128c		Rv1128c			
NC_002945.3	Mycobrowser_v4	CDS	3536171	3537049	.	-	0	Mb3230c	Mb3230c		conserved protein	Mb3230c, -, len: 292 aa. Equivalent to Rv3205c,len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Hypothetical protein,highly similar to Q9CCG7|ML0818 HYPOTHETICAL PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745,E(): 9.1e-98, (87.3% identity in 291 aa overlap).	Q7TX08	No	conserved hypotheticals							IPR013402	Q7TX08					Rv3205c		Rv3205c			
NC_002945.3	Mycobrowser_v4	CDS	1249453	1250697	.	+	0	Mb1156	Mb1156		CONSERVED HYPOTHETICAL PROTEIN	Mb1156, -, len: 414 aa. Equivalent to Rv1125, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 414 aa overlap). Conserved hypothetical protein. Similar to AL133278|SCM11.13 hypothetical protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 182, E(): 0.0005, (28.1% identity in 437 aa overlap).	Q7U0L4,A0A1R3XXF7	No	conserved hypotheticals			A0A1R3XXF7					Q7U0L4					Rv1125		Rv1125			
NC_002945.3	Mycobrowser_v4	CDS	1250701	1251306	.	-	0	Mb1157c	Mb1157c		conserved protein	Mb1157c, -, len: 201 aa. Equivalent to Rv1126c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Conserved hypothetical protein, similar in N-terminus to O05567|MLCB33.17 hypothetical protein from Mycobacterium leprae (141 aa),FASTA scores: opt: 332, E(): 1.4e-23, (58.4% identity in 101 aa overlap).	Q7U0L3,A0A1R3XXF2	No	conserved hypotheticals			A0A1R3XXF2					Q7U0L3					Rv1126c		Rv1126c			
NC_002945.3	Mycobrowser_v4	CDS	1254445	1255905	.	-	0	Mb1160c	Mb1160c		PROBABLE TRANSCRIPTIONAL REGULATOR PROTEIN	Mb1160c, -, len: 486 aa. Equivalent to Rv1129c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 486 aa overlap). Possible transcriptional regulator protein, similar to Rv0465c|MTV038.09c Mycobacterium tuberculosis (474 aa),FASTA scores: E(): 0, (47.4% identity in 468 aa overlap). Helix turn helix motif present from aa 32-53.	Q7U0L0,A0A1R3XXF4	No	regulatory proteins			A0A1R3XXF4				IPR001387,IPR010359,IPR010982,IPR018653,IPR026281	Q7U0L0					Rv1129c		Rv1129c			
NC_002945.3	Mycobrowser_v4	CDS	1258696	1260426	.	+	0	Mb1163	Mb1163		CONSERVED MEMBRANE PROTEIN	Mb1163, -, len: 576 aa. Equivalent to Rv1132, len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 576 aa overlap). Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa), fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap).	Q7U0K7,A0A1R3XYE9	No	cell wall and cell processes			A0A1R3XYE9				IPR021941	Q7U0K7					Rv1132		Rv1132			
NC_002945.3	Mycobrowser_v4	CDS	1336177	1337004	.	+	0	Mb1224	Mb1224		unknown protein	Mb1224, -, len: 275 aa. Equivalent to Rv1192, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Hypothetical unknown protein, contains PS00120 lipases, serine active site.	Q7U0F3,A0A1R3XXZ3	No	conserved hypotheticals			A0A1R3XXZ3					Q7U0F3					Rv1192		Rv1192			
NC_002945.3	Mycobrowser_v4	CDS	1266843	1267859	.	-	0	Mb1170c	Mb1170c		possible oxidoreductase	Mb1170c, -, len: 338 aa. Equivalent to Rv1138c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 338 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to Q9EWQ8 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89, E(): 4.5e-09, (24.6% identity in 358 aa overlap).	Q7U0K1,A0A1R3XXG4	No	intermediary metabolism and respiration			A0A1R3XXG4				IPR002938,IPR003042	Q7U0K1					Rv1138c		Rv1138c			
NC_002945.3	Mycobrowser_v4	CDS	1267856	1268356	.	-	0	Mb1171c	Mb1171c		CONSERVED HYPOTHETICAL MEMBRANE PROTEIN	Mb1171c, -, len: 166 aa. Equivalent to Rv1139c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 166 aa overlap). Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein, YBPQ (168 aa),FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740, Rv0750.	Q7U0K0,A0A1R3XXH0	No	cell wall and cell processes			A0A1R3XXH0				IPR007269	Q7U0K0					Rv1139c		Rv1139c			
NC_002945.3	Mycobrowser_v4	CDS	1268718	1269566	.	+	0	Mb1172	Mb1172		PROBABLE INTEGRAL MEMBRANE PROTEIN	Mb1172, -, len: 282 aa. Equivalent to Rv1140, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 282 aa overlap). Probable integral membrane protein. Weak similarity in C-terminus to hypothetical Escherichia coli proteins YPRA and YPRB,possibly membrane-bound e.g. YPRA_ECOLI HYPOTHETICAL 24.3 KD PROTEIN (URF 1) (217 aa), FASTA scores: opt: 166, E(): 0.00062, (31.0% identity in 158 aa overlap).	Q7U0J9,A0A1R3XZK2	No	cell wall and cell processes			A0A1R3XZK2				IPR003675	Q7U0J9					Rv1140		Rv1140			
NC_002945.3	Mycobrowser_v4	CDS	1279641	1280189	.	+	0	Mb1181	Mb1181		POSSIBLE TRANSPOSASE (FRAGMENT)	Mb1181, -, len: 183 aa. Equivalent to Rv1150, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 183 aa overlap). Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of putative Mycobacterium tuberculosis IS element (308 aa), FASTA scores: opt: 959, E(): 0,(99.3% identity in 145 aa overlap). The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08. TBparse score is 0.914.		No	insertion seqs and phages													Rv1150		Rv1150			
NC_002945.3	Mycobrowser_v4	CDS	1272527	1273279	.	+	0	Mb1176	Mb1176		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb1176, -, len: 250 aa. Equivalent to Rv1144, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 250 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. NP_104056.1|NC_002678 3-hydroxyacyl-CoA dehydrogenase type II from Mesorhizobium loti (253 aa); NP_251244.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (255 aa); AAK15008.1|AF233685_1|AF233685 short chain L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus (261 aa); HSU73514|g1778354|XH98G2 human short-chain alcohol dehydrogenase from Homo sapiens (261 aa), FASTA scores: opt: 875, E(): 0, (60.1% identity in 253 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7U0J5,A0A1R3XXH8	No	intermediary metabolism and respiration			A0A1R3XXH8				IPR002198,IPR002347,IPR016040,IPR020904	Q7U0J5					Rv1144		Rv1144			
NC_002945.3	Mycobrowser_v4	CDS	1276272	1276922	.	+	0	Mb1178	Mb1178		conserved protein	Mb1178, -, len: 216 aa. Equivalent to Rv1147, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 216 aa overlap). Conserved hypothetical protein, similar to many conserved hypothetical proteins,and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) from R. sphaeroides (203 aa), FASTA scores: opt: 156, E( ): 0.00073, (27.6% identity in 156 aa overlap).	Q7U0J3,A0A1R3XXH3	No	conserved hypotheticals			A0A1R3XXH3					Q7U0J3					Rv1147		Rv1147			
NC_002945.3	Mycobrowser_v4	CDS	1277672	1279120	.	-	0	Mb1179c	Mb1179c		CONSERVED HYPOTHETICAL PROTEIN	Mb1179c, -, len: 482 aa. Equivalent to Rv1148c,len: 482 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 482 aa overlap). Conserved hypothetical ORF in REP13E12 degenerate repeat, nearly identical to other hypothetical Mycobacterium tuberculosis proteins in REP13E12 repeats, although similarity extends upstream past proposed f-Met start. Very similar to other REP13E12 proteins e.g. Rv1945, Rv3467, Rv0094c, Rv1128c etc.	X2BHH0,P0A5E0,P0A5E0	No	insertion seqs and phages			P0A5E0					X2BHH0,P0A5E0					Rv1148c		Rv1148c			
NC_002945.3	Mycobrowser_v4	CDS	1280276	1280989	.	-	0	Mb1182c	Mb1182c		transcriptional regulatory protein	Mb1182c, -, len: 237 aa. Equivalent to Rv1151c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 237 aa overlap). Probable transcriptional regulatory protein, similar to others AE000776|AE000776_10 Aquifex aeolicus (239 aa), FASTA scores: opt: 725, E(): 0, (46.4% identity in 237 aa overlap); ECAE0002125|g1787358 Escherichia coli (279 aa),FASTA scores: opt: 464, E(): 1.3e-23, (36.7% identity in 240 aa overlap).	X2BH48,P66814,P66814	No	regulatory proteins			P66814					X2BH48,P66814					Rv1151c		Rv1151c			
NC_002945.3	Mycobrowser_v4	CDS	1281027	1281392	.	+	0	Mb1183	Mb1183		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1183, -, len: 121 aa. Equivalent to Rv1152, len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 121 aa overlap). Start uncertain. Probable transcriptional regulatory protein, some similarity to others e.g. YHCF_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR (121 aa), FASTA scores: opt: 187, E(): 1.9e-06, (34.9% identity in 106 aa overlap). TBparse score is 0.876. Helix turn helix motif from aa 42-63 (+3.10 SD).	Q7U0J0,A0A1R3XYG5	No	regulatory proteins			A0A1R3XYG5				IPR000524,IPR011991	Q7U0J0					Rv1152		Rv1152			
NC_002945.3	Mycobrowser_v4	CDS	1282801	1283244	.	+	0	Mb1186	Mb1186		possible pyridoxamine 5'-phosphate oxidase (pnp/pmp oxidase) (pyridoxinephosphate oxidase) (pnpox) (pyridoxine 5'-phosphate oxidase)	Mb1186, -, len: 147 aa. Equivalent to Rv1155, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 147 aa overlap). Conserved hypothetical protein. Similar to other hypothetical proteins e.g. AL079356|SC6G9.20 Streptomyces coelicolor (144 aa), FASTA scores: opt: 478, E(): 2.8e-26, (55.7% identity in 140 aa overlap); and Mycobacterium tuberculosis proteins Rv1875,Rv0121c, Rv2074.	Q7U0I7,A0A1R3XXI7	No	intermediary metabolism and respiration			A0A1R3XXI7				IPR011576,IPR012349,IPR019920	Q7U0I7					Rv1155		Rv1155			
NC_002945.3	Mycobrowser_v4	CDS	1283402	1283590	.	+	0	Mb1186A	Mb1186A		HYPOTHETICAL PROTEIN	Mb1186A, -, len: 62 aa. Equivalent to hypothetical protein MT1190 from Mycobacterium tuberculosis strain CDC1551 (100% identity with 62 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al.,2013). Mb1186A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BH54,A0A1R3XXI2	No				A0A1R3XXI2					X2BH54										
NC_002945.3	Mycobrowser_v4	CDS	1283678	1284265	.	+	0	Mb1187	Mb1187		conserved protein	Mb1187, -, len: 195 aa. Equivalent to Rv1156, len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 195 aa overlap). Conserved hypothetical protein, highly similar to CAC32318.1|AL583944 conserved hypothetical protein from Streptomyces coelicolor (197 aa).	Q7U0I6,A0A1R3XXI5	No	conserved hypotheticals			A0A1R3XXI5				IPR003265,IPR011257,IPR017658	Q7U0I6					Rv1156		Rv1156			
NC_002945.3	Mycobrowser_v4	CDS	1284428	1285543	.	-	0	Mb1188c	Mb1188c		conserved ala-, pro-rich protein	Mb1188c, -, len: 371 aa. Equivalent to Rv1157c,len: 371 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 371 aa overlap). Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. GBU04267|g451543 sea-island cotton proline-rich protein of cotton fiber (214 aa),FASTA scores: opt: 305, E(): 3.9e-05, (35.7% identity in 182 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. First start taken.	Q7U0I5,A0A1R3XXJ5	No	conserved hypotheticals			A0A1R3XXJ5				IPR003882	Q7U0I5					Rv1157c		Rv1157c			
NC_002945.3	Mycobrowser_v4	CDS	1285551	1286234	.	-	0	Mb1189c	Mb1189c		CONSERVED HYPOTHETICAL ALA-, PRO-RICH PROTEIN	Mb1189c, -, len: 227 aa. Equivalent to Rv1158c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 227 aa overlap). Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa), FASTA scores: opt: 367, E(): 1.2e-08, (36.3% identity in 212 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal.	Q7U0I4,A0A1R3XXI3	No	conserved hypotheticals			A0A1R3XXI3					Q7U0I4					Rv1158c		Rv1158c			
NC_002945.3	Mycobrowser_v4	CDS	1299459	1300064	.	-	0	Mb1199c	Mb1199c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1199c, -, len: 201 aa. Equivalent to Rv1167c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Probable transcriptional regulator, similar to several e.g. D1022772|D85417 hemR from Propionibacterium freudenreichii (243 aa), FASTA scores: opt: 268, E(): 5.4e-16, (35.9% identity in 198 aa overlap) and AL022268|SC4H2.32 Streptomyces coelicolor (111 aa), FASTA scores: opt: 274,E(): 5e-11, (55.1% identity in 89 aa overlap).	Q7U0H5,A0A1R3XXJ2	No	regulatory proteins			A0A1R3XXJ2				IPR001647,IPR009057,IPR011075,IPR015893	Q7U0H5					Rv1167c		Rv1167c			
NC_002945.3	Mycobrowser_v4	CDS	1328939	1330555	.	-	0	Mb1218c	Mb1218c		conserved protein	Mb1218c, -, len: 538 aa. Equivalent to Rv1186c,len: 538 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 538 aa overlap). Conserved hypothetical protein, similar to AL117385|SC5G9.24 hypothetical protein from Streptomyces coelicolor (555 aa), FASTA scores: opt: 485, E(): 2.3e-23, (32.6% identity in 568 aa overlap). Contains helix turn helix motif from aa 488-509 (+2.81 SD).	Q7U0F9,A0A1R3XXM3	No	conserved hypotheticals			A0A1R3XXM3				IPR025736	Q7U0F9					Rv1186c		Rv1186c			
NC_002945.3	Mycobrowser_v4	CDS	1309472	1310041	.	-	0	Mb1209c	Mb1209c		CONSERVED HYPOTHETICAL PROTEIN	Mb1209c, -, len: 189 aa. Equivalent to Rv1176c,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 189 aa overlap). Conserved hypothetical protein, some similarity to P94443|D78508 hypothetical protein from Bacillus subtilis (182 aa), FASTA scores: opt: 219, E(): 1.7e-15, (25.1% identity in 183 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv0047c.	Q7U0G6,A0A1R3XXK1	No	conserved hypotheticals			A0A1R3XXK1				IPR005149,IPR011991,IPR018309	Q7U0G6					Rv1176c		Rv1176c			
NC_002945.3	Mycobrowser_v4	CDS	1310613	1311701	.	+	0	Mb1211	Mb1211		PROBABLE AMINOTRANSFERASE	Mb1211, -, len: 362 aa. Equivalent to Rv1178, len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 362 aa overlap). Probable aminotransferase (EC 2.6.1.-), weak similarity to many aspartate aminotransferases e.g. Q55679|D64000 SLL0006 aspartate aminotransferase from Synechocystis sp. (394 aa), FASTA scores: opt: 218, E(): 1.3e-25, (32.5% identity in 379 aa overlap). Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. Also similar to Mycobacterium tuberculosis aminotransferases Rv2294,Rv0075, etc.	Q7U0G4,A0A1R3XZP9	No	intermediary metabolism and respiration			A0A1R3XZP9				IPR004838,IPR004839,IPR015421,IPR015422,IPR015424,IPR019880	Q7U0G4					Rv1178		Rv1178			
NC_002945.3	Mycobrowser_v4	CDS	1311729	1314548	.	-	0	Mb1212c	Mb1212c		unknown protein	Mb1212c, -, len: 939 aa. Equivalent to Rv1179c,len: 939 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 939 aa overlap). Hypothetical unknown protein.	Q7U0G3,A0A1R3XYJ4	No	conserved hypotheticals			A0A1R3XYJ4				IPR001650,IPR006935,IPR014001,IPR027417	Q7U0G3					Rv1179c		Rv1179c			
NC_002945.3	Mycobrowser_v4	CDS	1325782	1326861	.	-	0	Mb1216c	Mb1216c		POSSIBLE EXPORTED PROTEIN	Mb1216c, -, len: 359 aa. Equivalent to Rv1184c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 359 aa overlap). Possible exported protein with potential N-terminal signal sequence. Similar to several Mycobacterial hypothetical proteins e.g. Q49633|U00010) Protein B1170_F3_112 from M. leprae (391 aa), FASTA scores: opt: 1422, E(): 0, (62.7% identity in 338 aa overlap). Also similar to Rv3822, Rv3539, Rv1430,Rv0151c, etc.	Q7U0G0,A0A1R3XXL5	No	cell wall and cell processes			A0A1R3XXL5				IPR013228	Q7U0G0					Rv1184c		Rv1184c			
NC_002945.3	Mycobrowser_v4	CDS	1334230	1335108	.	+	0	Mb1222	Mb1222		CONSERVED HYPOTHETICAL PROTEIN	Mb1222, -, len: 292 aa. Equivalent to Rv1190, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 292 aa overlap). Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kd protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap),also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap).	Q7U0F5,A0A1R3XYK6	No	conserved hypotheticals			A0A1R3XYK6					Q7U0F5					Rv1190		Rv1190			
NC_002945.3	Mycobrowser_v4	CDS	1370076	1371539	.	-	0	Mb1258c	Mb1258c		PROBABLE TRANSMEMBRANE PROTEIN	Mb1258c, -, len: 487 aa. Equivalent to Rv1226c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 487 aa overlap). Probable transmembrane protein. Some similarity to AL049841|SCE9.01 Streptomyces coelicolor (436 aa), FASTA scores: opt: 203, E(): 1.2e-05,(29.8% identity in 346 aa overlap).	Q7U0C5,A0A1R3XXR6	No	cell wall and cell processes			A0A1R3XXR6				IPR005182,IPR014529	Q7U0C5					Rv1226c		Rv1226c			
NC_002945.3	Mycobrowser_v4	CDS	1332271	1333260	.	+	0	Mb1220	Mb1220		PROBABLE PROLINE DEHYDROGENASE	Mb1220, -, len: 329 aa. Equivalent to Rv1188, len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 329 aa overlap). Possible putA, proline dehydrogenase (EC 1.5.99.8), similar to part of Q52711|X78346 proline dehydrogenase from Rhodobacter capsulatus (1127 aa), FASTA scores: opt: 194, E(): 1.5e-07, (31.2% identity in 349 aa overlap). Also similar to two Bacillus subtilis proline dehydrohenases E1184363|Z99120 (302 aa), FASTA scores: opt: 509, E(): 0,(37.1% identity in 313 aa overlap); and E1182272|Z99105 (303 aa), FASTA scores: opt: 513, E(): 0, (32.5% identity in 311 aa overlap). Highly similar to AL035569|SC8D9.31 Streptomyces coelicolor (308 aa), FASTA scores: opt: 984,E(): 0, (50.0% identity in 312 aa overlap).	Q7U0F7,A0A1R3XXM0	No	intermediary metabolism and respiration			A0A1R3XXM0				IPR002872,IPR008219	Q7U0F7					Rv1188		Rv1188			
NC_002945.3	Mycobrowser_v4	CDS	1335181	1336095	.	+	0	Mb1223	Mb1223		conserved protein	Mb1223, -, len: 304 aa. Equivalent to Rv1191, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 304 aa overlap). Conserved hypothetical protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 269 aa overlap); Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): 6.6e-06, (26.4% identity in 299 aa overlap), some similarity to PIP_NEIGO|P42786 proline iminopeptidase (EC 3.4.11.5) (310 aa), FASTA scores: opt: 196, E(): 1.3e-05,(32.2% identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature.	Q7U0F4,A0A1R3XXN6	No	conserved hypotheticals			A0A1R3XXN6					Q7U0F4					Rv1191		Rv1191			
NC_002945.3	Mycobrowser_v4	CDS	1338498	1339763	.	-	0	Mb1226c	Mb1226c		conserved protein	Mb1226c, -, len: 421 aa. Equivalent to Rv1194c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 421 aa overlap). Conserved hypothetical protein, highly similar to Q50018 possible transcriptional activator from Mycobacterium leprae (517 aa), FASTA scores: opt: 1960, E(): 0, (69.8% identity in 421 aa overlap). Also similar to Mycobacterium tuberculosis Rv2370c|MTCY27.10, (62.0% identity in 421 aa overlap) and Rv1453|MTCY493.01c.	Q7U0F1,A0A1R3XXM4	No	conserved hypotheticals			A0A1R3XXM4				IPR025736	Q7U0F1					Rv1194c		Rv1194c			
NC_002945.3	Mycobrowser_v4	CDS	1354404	1354772	.	+	0	Mb1241	Mb1241		conserved protein	Mb1241, -, len: 122 aa. Equivalent to Rv1209, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 122 aa overlap). Conserved hypothetical protein, containing a hydrophobic N-terminus. Similar to Q49956|U1756M hypothetical protein from Mycobacterium leprae (114 aa), FASTA scores: opt: 524, E(): 8.9e-29,(78.6% identity in 112 aa overlap).	Q7U0E0,A0A1R3XZT7	No	conserved hypotheticals			A0A1R3XZT7				IPR019933	Q7U0E0					Rv1209		Rv1209			
NC_002945.3	Mycobrowser_v4	CDS	1348183	1349871	.	-	0	Mb1236c	Mb1236c		CONSERVED HYPOTHETICAL PROTEIN	Mb1236c, -, len: 562 aa. Equivalent to Rv1204c,len: 562 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 562 aa overlap). Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from STREPTOMYCES SP. (642 aa), FASTA scores: opt: 215, E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.	Q7U0E4,A0A1R3XXN3	No	conserved hypotheticals			A0A1R3XXN3				IPR003593,IPR027417	Q7U0E4					Rv1204c		Rv1204c			
NC_002945.3	Mycobrowser_v4	CDS	1342605	1343852	.	-	0	Mb1231c	Mb1231c		POSSIBLE TRANSPOSASE	Mb1231c, -, len: 415 aa. Equivalent to Rv1199c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). Possible transposase for IS1081, identical to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa); region identical to MTCY441.35 (100.0% identity in 261 aa overlap); and almost identical to MTCY10G2.02c (415 aa) (99.8% identity in 415 aa overlap). Contains PS01007 Transposases, Mutator family, signature, PS00435 Peroxidases proximal heme-ligand signature.	X2BGW7,P60231,P60231	No	insertion seqs and phages			P60231					X2BGW7,P60231					Rv1199c		Rv1199c			
NC_002945.3	Mycobrowser_v4	CDS	1344189	1345466	.	+	0	Mb1232	Mb1232		PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN	Mb1232, -, len: 425 aa. Equivalent to Rv1200, len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 425 aa overlap). Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. YHJE_ECOLI|P37643 hypothetical metabolite transport protein from Escherichia coli (440 aa), FASTA scores: opt: 1047, E(): 0, (39.1% identity in 427 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2.	Q7U0E8,A0A1R3XYL7	No	cell wall and cell processes			A0A1R3XYL7				IPR004736,IPR005828,IPR005829,IPR016196,IPR020846	Q7U0E8					Rv1200		Rv1200			
NC_002945.3	Mycobrowser_v4	CDS	1347568	1348152	.	-	0	Mb1235c	Mb1235c		HYPOTHETICAL PROTEIN	Mb1235c, -, len: 194 aa. Equivalent to Rv1203c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 194 aa overlap). Hypothetical unknown protein.	Q7U0E5,A0A1R3XXN7	No	conserved hypotheticals			A0A1R3XXN7				IPR011990	Q7U0E5					Rv1203c		Rv1203c			
NC_002945.3	Mycobrowser_v4	CDS	1378220	1378747	.	+	0	Mb1266	Mb1266		PROBABLE TRANSMEMBRANE PROTEIN	Mb1266, -, len: 175 aa. Equivalent to Rv1234, len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 175 aa overlap). Possible transmembrane protein with two TM helices.	Q7U0B8,A0A1R3XXR1	No	cell wall and cell processes			A0A1R3XXR1					Q7U0B8					Rv1234		Rv1234			
NC_002945.3	Mycobrowser_v4	CDS	1349966	1350529	.	+	0	Mb1237	Mb1237		CONSERVED HYPOTHETICAL PROTEIN	Mb1237, -, len: 187 aa. Equivalent to Rv1205, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 187 aa overlap). Conserved hypothetical protein, similar to Q49952 cosmid B1756 from Mycobacterium leprae (187 aa), FASTA scores: opt: 865, E(): 0, (72.4% identity in 174 aa overlap), also similar to FAS6_RHOFA|P46378 hypothetical 21.1 kd protein in fasciation locus (ORF6) (198 aa), FASTA scores: opt: 368,E(): 1.3e-17, (37.4% identity in 174 aa overlap). Some similarity to YJL055W Hypothetical protein in BTN1-PEP8 intergenic region from Saccharomyces cerevisiae and P48636 HYPOTHETICAL protein in AZU 5'REGION from Pseudomonas AERUGINOSA.	Q7U0E3,A0A1R3XXN4	No	conserved hypotheticals			A0A1R3XXN4				IPR005269	Q7U0E3					Rv1205		Rv1205			
NC_002945.3	Mycobrowser_v4	CDS	1415804	1416502	.	-	0	Mb1299c	Mb1299c		HYPOTHETICAL PROTEIN	Mb1299c, -, len: 232 aa. Equivalent to Rv1268c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 232 aa overlap). Hypothetical unknown protein, probably secreted protein : contains possible signal peptide sequence (score 7.9 at residue 28).	X2BHH1,P64792	No	conserved hypotheticals			P64792					X2BHH1					Rv1268c		Rv1268c			
NC_002945.3	Mycobrowser_v4	CDS	1359001	1360686	.	-	0	Mb1247c	Mb1247c		conserved protein	Mb1247c, -, len: 561 aa. Equivalent to Rv1215c,len: 561 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 561 aa overlap). Conserved hypothetical protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kd protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap).	Q7U0D5,A0A1R3XXP5	No	conserved hypotheticals			A0A1R3XXP5				IPR000383,IPR005674,IPR008979,IPR013736	Q7U0D5					Rv1215c		Rv1215c			
NC_002945.3	Mycobrowser_v4	CDS	1360714	1361388	.	-	0	Mb1248c	Mb1248c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb1248c, -, len: 224 aa. Equivalent to Rv1216c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 224 aa overlap). Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap).	Q7U0D4,A0A1R3XXQ5	No	cell wall and cell processes			A0A1R3XXQ5				IPR007318	Q7U0D4					Rv1216c		Rv1216c			
NC_002945.3	Mycobrowser_v4	CDS	1369135	1369965	.	-	0	Mb1257c	Mb1257c		CONSERVED HYPOTHETICAL PROTEIN	Mb1257c, -, len: 276 aa. Equivalent to Rv1225c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 276 aa overlap). Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. AE001078|AE001078_2 Archaeoglobus fulgidus (265 aa),FASTA scores: opt: 339, E(): 5.1e-15, (27.1% identity in 262 aa overlap), and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa), FASTA scores: opt: 167,E(): 6.4e-12, (24.8% identity in 258 aa overlap). Also weakly similar to Mycobacterium tuberculosis hypothetical protein Rv3400|MTCY78.28c (29.1% identity in 251 aa overlap).	Q7U0C6,A0A1R3XXQ2	No	conserved hypotheticals			A0A1R3XXQ2				IPR006357,IPR023214,IPR023215	Q7U0C6					Rv1225c		Rv1225c			
NC_002945.3	Mycobrowser_v4	CDS	1361397	1363043	.	-	0	Mb1249c	Mb1249c		PROBABLE TETRONASIN-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER	Mb1249c, -, len: 548 aa. Equivalent to Rv1217c,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Probable tetronasin-transport integral membrane ABC transporter (see citation below), similar to many e.g. AL049754|SCH10_12 probable ABC-type transport system membrane-spanning protein from Streptomyces coelicolor (539 aa), FASTA scores: opt: 1309, E(): 0, (40.9% identity in 550 aa overlap); Q54407|X73633 TnrB3 protein from Streptomyces longisporoflavus (337 aa), FASTA scores: opt: 692, E(): 0, (39.5% identity in 324 aa overlap); etc. Also has regions similar to Mycobacterium leprae proteins Q49964|U1756Q (109 aa), FASTA scores: opt: 431, E(): 3.1e-20, (64.8% identity in 105 aa overlap) and Q49965|U1756R (82 aa), FASTA scores: opt:154, E(): 0.0028,(61.0% identity in 41 aa overlap).	Q7U0D3,A0A1R3XXP2	No	cell wall and cell processes			A0A1R3XXP2					Q7U0D3					Rv1217c		Rv1217c			
NC_002945.3	Mycobrowser_v4	CDS	1363040	1363975	.	-	0	Mb1250c	Mb1250c		PROBABLE TETRONASIN-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1250c, -, len: 311 aa. Equivalent to Rv1218c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 311 aa overlap). Probable tetronasin-transport ATP-binding protein ABC transporter (see citation below), similar to many e.g. Q54406|X73633|TNRB2 TNRB2 PROTEIN from Streptomyces longisporoflavus (300 aa), FASTA scores: opt: 1133, E(): 0, (60.8% identity in 291 aa overlap); etc. Also similar to others in Mycobacterium tuberculosis e.g. MTCY19H9.04 (30.0% identity in 297 aa overlap); etc. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)	Q7U0D2,A0A1R3XXQ1	No	cell wall and cell processes			A0A1R3XXQ1				IPR003439,IPR003593,IPR017871,IPR027417	Q7U0D2					Rv1218c		Rv1218c			
NC_002945.3	Mycobrowser_v4	CDS	1363965	1364603	.	-	0	Mb1251c	Mb1251c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1251c, -, len: 212 aa. Equivalent to Rv1219c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 212 aa overlap). Probable transcriptional regulatory protein, some similarity in N-terminus to YBIH_ECOLI|P41037 hypothetical transcriptional regulator from Escherichia coli (103 aa),FASTA scores: opt: 143, E(): 8.9e-06, (39.7% identity in 63 aa overlap); Helix turn helix motif from aa 28-49.	Q7U0D1,A0A1R3XZU0	No	regulatory proteins			A0A1R3XZU0				IPR001647,IPR009057,IPR011075,IPR015893	Q7U0D1					Rv1219c		Rv1219c			
NC_002945.3	Mycobrowser_v4	CDS	1364745	1365392	.	-	0	Mb1252c	Mb1252c		PROBABLE METHYLTRANSFERASE	Mb1252c, -, len: 215 aa. Equivalent to Rv1220c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Possible methyltransferase (EC 2.1.1.-), some similarity to MDMC_STRMY|Q00719 o-methyltransferase from Streptomyces mycarofaciens (221 aa), FASTA scores; opt: 289, E(): 1.3e-07, (30.0% identity in 203 aa overlap). Also similar to Mycobacterium tuberculosis methyltransferases Rv0187|MTCI28.26 (32.9% identity in 222 aa overlap) and Rv1703c. Start site chosen by homology; other possible start sites exist upstream.	X2BH72,Q7U0D0,Q7U0D0	No	intermediary metabolism and respiration			Q7U0D0					X2BH72,Q7U0D0					Rv1220c		Rv1220c			
NC_002945.3	Mycobrowser_v4	CDS	1374206	1375441	.	-	0	Mb1262c	Mb1262c		POSSIBLE MEMBRANE PROTEIN	Mb1262c, -, len: 411 aa. Equivalent to Rv1230c,len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 411 aa overlap). Possible membrane protein with two hydrophobic stretches near N-terminus. Some similarity to Rv1022|MTCY10G2.27c|Z92539 probable lpqU protein from Mycobacterium tuberculosis (243 aa),FASTA score: opt: 408, E(): 1e-11, (43.6% identity in 172 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa), FASTA score: opt: 679, E(): 5.1e-23, (36.4% identity in 398 aa overlap).	Q7U0C2,A0A1R3XYP6	No	cell wall and cell processes			A0A1R3XYP6				IPR001827,IPR023346	Q7U0C2					Rv1230c		Rv1230c			
NC_002945.3	Mycobrowser_v4	CDS	1375566	1376108	.	-	0	Mb1263c	Mb1263c		PROBABLE MEMBRANE PROTEIN	Mb1263c, -, len: 180 aa. Equivalent to Rv1231c,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 180 aa overlap). Probable membrane protein, similar to others e.g. AL390975 Streptomyces coelicolor (198 aa).	Q7U0C1,A0A1R3XXS0	No	cell wall and cell processes			A0A1R3XXS0				IPR010406	Q7U0C1					Rv1231c		Rv1231c			
NC_002945.3	Mycobrowser_v4	CDS	1376105	1377412	.	-	0	Mb1264c	Mb1264c		conserved protein	Mb1264c, -, len: 435 aa. Equivalent to Rv1232c,len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 435 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. AB013374|AB013374_2 Bacillus halodurans C-125 mamX (449 aa), FASTA scores: opt: 381, E(): 1e-16, (29.9% identity in 251 aa overlap). Some similarity in N-terminus to U15180|MLU1518033 hypothetical Mycobacterium leprae protein u1756u (329 aa), FASTA scores: opt: 300, E(): 4.1e-12, (69.3% identity in 75 aa overlap).	Q7U0C0,A0A1R3XY33	No	conserved hypotheticals			A0A1R3XY33				IPR000644,IPR006668,IPR011033	Q7U0C0					Rv1232c		Rv1232c			
NC_002945.3	Mycobrowser_v4	CDS	1377474	1378070	.	-	0	Mb1265c	Mb1265c		CONSERVED HYPOTHETICAL MEMBRANE PROTEIN	Mb1265c, -, len: 198 aa. Equivalent to Rv1233c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 198 aa overlap). Conserved hypothetical membrane protein, N-terminus is highly proline rich,C-terminus has two hydrophobic stretches. Proline-rich N-terminus has some similarity to CBPA_DICDI calcium binding protein from Dictyostelium discoideum (467 aa),FASTA scores: E(): 4.8e-06, (35.5% identity in 183 aa overlap). Both sequences share multiple copies of a Tyr-Pro-Pro motif.	Q7U0B9,A0A1R3XXR7	No	cell wall and cell processes			A0A1R3XXR7				IPR025241	Q7U0B9					Rv1233c		Rv1233c			
NC_002945.3	Mycobrowser_v4	CDS	1389042	1389872	.	-	0	Mb1277c	Mb1277c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb1277c, -, len: 276 aa. Equivalent to Rv1245c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 276 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to NP_301801.1|NC_002677 short chain alcohol dehydrogenase from Mycobacterium leprae (277 aa). Also highly similar to various dehydrogenases and oxidoreductases e.g. NP_250228.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (295 aa); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3085|MTV013.06 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (276 aa), FASTA scores: opt: 368,E(): 1.2e-16, (35.3% identity in 224 aa overlap); Rv3057c|MTCY22D7.24 PUTATIVE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE (287 aa), FASTA scores: opt: 471,E(): 1.3e-21, (32.4% identity in 281 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7U0A9,A0A1R3XXS4	No	intermediary metabolism and respiration			A0A1R3XXS4				IPR002198,IPR002347,IPR016040,IPR020904	Q7U0A9					Rv1245c		Rv1245c			
NC_002945.3	Mycobrowser_v4	CDS	1395423	1397162	.	+	0	Mb1282	Mb1282		PROBABLE DRUG-TRANSPORT INTEGRAL MEMBRANE PROTEIN	Mb1282, -, len: 579 aa. Equivalent to Rv1250, len: 579 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 579 aa overlap). Probable drug-transport integral membrane protein, member of major facilitator superfamily (MFS), highly similar to several including P39886|TCMA_STRGA TETRACENOMYCIN C RESISTANCE PROTEIN from Streptomyces glaucescens (538 aa), FASTA scores: opt: 847, E(): 0, (32.9% identity in 517 aa overlap); etc. Also similar to MTCY20B11.14c|Rv3239C from Mycobacterium tuberculosis (1048 aa), FASTA scores: opt: 629, E(): 6.7e-13, (31.9% identity in 423 aa overlap). TBparse score is 0.921.	Q7U0A4,A0A1R3XYR8	No	cell wall and cell processes			A0A1R3XYR8				IPR004638,IPR011701,IPR016196,IPR020846	Q7U0A4					Rv1250		Rv1250			
NC_002945.3	Mycobrowser_v4	CDS	1418107	1418448	.	-	0	Mb1302c	Mb1302c		CONSERVED HYPOTHETICAL SECRETED PROTEIN	Mb1302c, -, len: 113 aa. Equivalent to Rv1271c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 113 aa overlap). Conserved hypothetical exported protein with potential N-terminal signal sequence. Similar to Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, Rv0622, etc.	X2BHA4,P64794	No	cell wall and cell processes			P64794					X2BHA4					Rv1271c		Rv1271c			
NC_002945.3	Mycobrowser_v4	CDS	1397065	1400484	.	-	0	Mb1283c	Mb1283c		CONSERVED HYPOTHETICAL PROTEIN	Mb1283c, -, len: 1139 aa. Equivalent to Rv1251c,len: 1139 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1139 aa overlap). Conserved hypothetical protein, showing some similarity in C-terminal region with other proteins from eukaryotes and bacteria e.g. NP_142121.1 hypothetical protein from Pyrococcus horikoshii (1188 aa); and some similarity to GTP-binding proteins e.g. P23249|MV10_MOUSE PUTATIVE GTP-BINDING PROTEIN (1004 aa), FASTA scores: opt: 228,E(): 1.7e-06, (27.7% identity in 560 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U0A3,A0A1R3XXU0	No	conserved hypotheticals			A0A1R3XXU0				IPR003593,IPR019993,IPR027417	Q7U0A3					Rv1251c		Rv1251c			
NC_002945.3	Mycobrowser_v4	CDS	1402902	1404053	.	+	0	Mb1286	Mb1286		PROBABLE ACYLTRANSFERASE	Mb1286, -, len: 383 aa. Equivalent to Rv1254, len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 383 aa overlap). Probable Acyltransferase (EC 2.3.1.-), similar to G927228 midecamycin 4-0-propionyl transferase (fragment) (388 aa),FASTA scores, opt: 305, E(): 5.6e-14, (28.4% identity in 377 aa overlap). Also similar to other Mycobacterium tuberculosis acyltransferases e.g. Rv0111, Rv0228, etc. Contains PS00881 Protein splicing signature.	Q7U0A1,A0A1R3XXT3	No	intermediary metabolism and respiration			A0A1R3XXT3				IPR002656	Q7U0A1					Rv1254		Rv1254			
NC_002945.3	Mycobrowser_v4	CDS	1418556	1420451	.	-	0	Mb1303c	Mb1303c		PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1303c, -, len: 631 aa. Equivalent to Rv1272c,len: 631 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 631 aa overlap). Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. Y015_MYCGE|P47261 hypothetical ABC transporter mg015m from Mycoplasma genitalium (589 aa), FASTA scores: opt: 1054,E(): 0, (34.3% identity in 522 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS),MSBA SUBFAMILY.	X2BHV5,P63398,P63398	No	cell wall and cell processes			P63398					X2BHV5,P63398					Rv1272c		Rv1272c			
NC_002945.3	Mycobrowser_v4	CDS	1404022	1404321	.	-	0	Mb1287c	Mb1287c		probable transcriptional regulatory protein	Mb1287c, -, len: 99 aa. Equivalent to 5' end of Rv1257c and 3' end of Rv1255c, len: 455 aa and 202 aa,from Mycobacterium tuberculosis strain H37Rv, (89.5% identity in 57 aa overlap and 83.6% identity in 67 aa overlap). Rv1257c: Probable oxidoreductase (EC 1.-.-.-),similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c. Rv1255c: Possible regulatory protein, similar to others e.g. ACRR_ECOLI|P34000 potential acrab operon repressor from E. coli (215 aa), FASTA scores: opt: 128, E(): 0.25, (42.1% identity in 57 aa overlap). Helix turn helix motif present at aa 36-57 (+5.48 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv.	Q7U0A0,A0A1R3XXT4	No				A0A1R3XXT4					Q7U0A0										
NC_002945.3	Mycobrowser_v4	CDS	1404318	1405577	.	-	0	Mb1288c	Mb1288c		PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN	Mb1288c, -, len: 419 aa. Equivalent to Rv1258c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 419 aa overlap). Probable conserved integral membrane transport (efflux) protein, possibly member of major facilitator superfamily (MFS), highly similar to O32859|TAP PROTEIN multidrug-resistance efflux pump from Mycobacterium fortuitum (409 aa), FASTA scores: E(): 0, (68.4% identity in 408 aa overlap). Contains PS00216 Sugar transport proteins signature 1.	X2BHU3,P64784,P64784	No	cell wall and cell processes			P64784					X2BHU3,P64784					Rv1258c		Rv1258c			
NC_002945.3	Mycobrowser_v4	CDS	1465737	1466171	.	+	0	Mb1344	Mb1344		CONSERVED HYPOTHETICAL SECRETED PROTEIN	Mb1344, -, len: 144 aa. Equivalent to Rv1312, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Conserved hypothetical secreted protein with potential N-terminal signal sequence. Highly similar to P53432|Y02W_MYCLE hypothetical Mycobacterium leprae protein (147 aa), FASTA score: opt: 884, E(): 0, (88.4% identity in 147 aa overlap). N-terminus hydrophobic. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2 bp deletion (cg-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa).	Q7U083,A0A1R3XXZ8	No	cell wall and cell processes			A0A1R3XXZ8				IPR019675	Q7U083					Rv1312		Rv1312			
NC_002945.3	Mycobrowser_v4	CDS	1406477	1407301	.	+	0	Mb1290	Mb1290		PROBABLE OXIDOREDUCTASE [FIRST PART]	Mb1290, -, len: 274 aa. Equivalent to 5' end of Rv1260, len: 372 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 260 aa overlap). Probable oxidoreductase (EC 1.-.-.-), highly similar to E1245747|AL021411 putative oxidoreductase SC7H1.18 from Streptomyces coelicolor (397 aa), FASTA scores: E(): 1.4e-29, (45.9% identity in 355 aa overlap); also some similarity to G912582 FAD binding protein homologue from Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245,E(): 2e-09, (27.5% identity in 251 aa overlap); PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity in 360 aa overlap); TETX_BACFR|Q01911 tetracycline resistance protein (388 aa), FASTA scores: opt: 183, E(): 3e-05, (22.8% identity in 373 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0575c and Rv1751. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts,Mb1290 and Mb1291.	Q7U099,A0A1R3XXU2	No				A0A1R3XXU2				IPR002938,IPR003042	Q7U099										
NC_002945.3	Mycobrowser_v4	CDS	1411496	1412176	.	+	0	Mb1296	Mb1296		unknown protein	Mb1296, -, len: 226 aa. Equivalent to Rv1265, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 226 aa overlap). Hypothetical unknown protein (see citation below).	X2BHK3,P64790	No	conserved hypotheticals			P64790					X2BHK3					Rv1265		Rv1265			
NC_002945.3	Mycobrowser_v4	CDS	1502391	1503113	.	+	0	Mb1372	Mb1372		PROBABLE INTEGRAL MEMBRANE PROTEIN	Mb1372, -, len: 240 aa. Equivalent to Rv1337, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 240 aa overlap). Probable integral membrane protein. Highly similar to P53426 hypothetical protein B1549_C3_240 from M.leprae (251); and P74553|D90916 hypothetical protein from Synechocystis sp. (198 aa), FASTA scores: E(): 2.3e-25, (43.6% identity in 181 aa overlap).	X2BHL6,P64816,P64816	No	cell wall and cell processes			P64816					X2BHL6,P64816					Rv1337		Rv1337			
NC_002945.3	Mycobrowser_v4	CDS	1407286	1407594	.	+	0	Mb1291	Mb1291		PROBABLE OXIDOREDUCTASE [SECOND PART]	Mb1291, -, len: 102 aa. Equivalent to 3' end of Rv1260, len: 372 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 102 aa overlap). Probable oxidoreductase (EC 1.-.-.-), highly similar to E1245747|AL021411 putative oxidoreductase SC7H1.18 from Streptomyces coelicolor (397 aa), FASTA scores: E(): 1.4e-29, (45.9% identity in 355 aa overlap); also some similarity to G912582 FAD binding protein homologue from Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245,E(): 2e-09, (27.5% identity in 251 aa overlap); PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity in 360 aa overlap); TETX_BACFR|Q01911 tetracycline resistance protein (388 aa), FASTA scores: opt: 183, E(): 3e-05, (22.8% identity in 373 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0575c and Rv1751. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts,Mb1290 and Mb1291.	Q7U098,A0A1R3XZY9	No				A0A1R3XZY9				IPR002938	Q7U098										
NC_002945.3	Mycobrowser_v4	CDS	1407720	1408169	.	-	0	Mb1292c	Mb1292c		conserved protein	Mb1292c, -, len: 149 aa. Equivalent to Rv1261c,len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 149 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1558|MTCY48.07c (39.2% identity in 125 aa overlap); Rv3547 and Rv3178.	X2BH95,P64788,P64788	No	conserved hypotheticals			P64788					X2BH95,P64788					Rv1261c		Rv1261c			
NC_002945.3	Mycobrowser_v4	CDS	1408174	1408608	.	-	0	Mb1293c	Mb1293c		HYPOTHETICAL HIT-LIKE PROTEIN	Mb1293c, -, len: 144 aa. Equivalent to Rv1262c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 144 aa overlap). Hypothetical HIT-like protein, similar to Q04344|HIT_YEAST hit1 protein (orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9 % identity in 142 aa overlap); also similar to YHIT_MYCGE|P47378 hypothetical 15.6 kd protein (141 aa),FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity in 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical 17.0 kd protein hit-like (155 aa), FASTA scores: opt: 196, E(): 7e-07, (30.6% identity in 144 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. Rv2613c, Rv0759c. Contains PS00892 HIT family signature. BELONGS TO THE HIT FAMILY.	Q7U097,A0A1R3XXU9	No	conserved hypotheticals			A0A1R3XXU9				IPR001310,IPR011146,IPR019808	Q7U097					Rv1262c		Rv1262c			
NC_002945.3	Mycobrowser_v4	CDS	1410130	1411323	.	+	0	Mb1295	Mb1295		ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE)	Mb1295, -, len: 397 aa. Equivalent to Rv1264, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Adenylate cyclase (EC 4.6.1.1) (function proven experimentally: see first citation below), showing some similarity to other adenylate cyclases e.g. CYAA_BRELI|P27580 (403 aa), FASTA scores, opt: 270, E(): 1.3e-10, (29.3% identity in 317 aa overlap); etc. Similar to other putative cyclases in M. tuberculosis e.g. Rv2212, Rv1647. BELONG TO THE ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY. The C terminus seems to code for a catalytic domain belonging to a subfamily of adenylyl cyclase isozymes (mostly found in Gram-positive bacteria). The N terminus seems to be a potential novel regulator of adenylyl cyclase activity (autoinhibitory domain).	Q7U096,A0A1R3XXU7	No	intermediary metabolism and respiration			A0A1R3XXU7				IPR001054	Q7U096					Rv1264		Rv1264			
NC_002945.3	Mycobrowser_v4	CDS	1516266	1516595	.	+	0	Mb1386	Mb1386		HYPOTHETICAL PROTEIN	Mb1386, -, len: 109 aa. Equivalent to Rv1351, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 109 aa overlap). Hypothetical unknown protein.	X2BHV3,P64822	No	conserved hypotheticals			P64822					X2BHV3					Rv1351		Rv1351			
NC_002945.3	Mycobrowser_v4	CDS	1420448	1422196	.	-	0	Mb1304c	Mb1304c		PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1304c, -, len: 582 aa. Equivalent to Rv1273c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 582 aa overlap). Probable drug-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. YWJA_BACSU|P45861 hypothetical abc transporter from Bacillus subtilis (575 aa), FASTA scores: opt: 810, E(): 0, (27.0% identity in 578 aa overlap); etc. Contains PS00136 Serine proteases,subtilase family, aspartic acid active site; 2 x PS00211 ABC transporters family signature; and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS),MSBA SUBFAMILY.	X2BHH5,P0A4W5,P0A4W5	No	cell wall and cell processes			P0A4W5					X2BHH5,P0A4W5					Rv1273c		Rv1273c			
NC_002945.3	Mycobrowser_v4	CDS	1423584	1424060	.	-	0	Mb1307c	Mb1307c		CONSERVED HYPOTHETICAL PROTEIN	Mb1307c, -, len: 158 aa. Equivalent to Rv1276c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 158 aa overlap). Conserved hypothetical protein, similar to AL096844|SCI28.03 hypothetical protein from Streptomyces coelicolor (172 aa), FASTA scores: opt: 385, E(): 3.3e-19, (43.5% identity in 161 aa overlap). Some similarity to P76502|SIXA_ECOLI PHOSPHOHISTIDINE PHOSPHATASE SIXA (161 aa), FASTA scores: opt: 146, E(): 0.0047, (31.9% identity in 116 aa overlap). BELONGS TO THE SIXA FAMILY OF PHOSPHATASES.	Q7U091,A0A1R3XXV5	No	conserved hypotheticals			A0A1R3XXV5				IPR013078	Q7U091					Rv1276c		Rv1276c			
NC_002945.3	Mycobrowser_v4	CDS	1424310	1425563	.	+	0	Mb1308	Mb1308		CONSERVED HYPOTHETICAL PROTEIN	Mb1308, -, len: 417 aa. Equivalent to Rv1277, len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 417 aa overlap). Conserved hypothetical protein, some similarity to 3914967|O68033|SBCD_RHOCA EXONUCLEASE SBCD HOMOLOG from Rhodobacter capsulatus (405 aa). May be sbcD protein (see first citation below)	Q7U090,A0A1R3XXW2	No	conserved hypotheticals			A0A1R3XXW2				IPR004843,IPR014577	Q7U090					Rv1277		Rv1277			
NC_002945.3	Mycobrowser_v4	CDS	1425560	1428187	.	+	0	Mb1309	Mb1309		HYPOTHETICAL PROTEIN	Mb1309, -, len: 875 aa. Equivalent to Rv1278, len: 875 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 875 aa overlap). Hypothetical unknown protein, possible coiled-coil regions, contains PS00017 ATP/GTP-binding site motif A.	X2BHH7,P64796	No	conserved hypotheticals			P64796					X2BHH7					Rv1278		Rv1278			
NC_002945.3	Mycobrowser_v4	CDS	1428208	1429794	.	+	0	Mb1310	Mb1310		PROBABLE DEHYDROGENASE FAD flavoprotein GMC oxidoreductase	Mb1310, -, len: 528 aa. Equivalent to Rv1279, len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 528 aa overlap). Probable dehydrogenase,FAD flavoprotein GMC oxidoreductase (EC 1.1.-.-), similar to several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from Escherichia coli (556 aa), FASTA scores, opt: 1047,E(): 0, (37.7% identity in 541 aa overlap). Similar to Rv0697 putative Mycobacterium tuberculosis GMC oxidoreductase. Contains PS00623 GMC oxidoreductases signature 1, and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC OXIDOREDUCTASES FAMILY.	X2BH98,P64264,P64264	No	intermediary metabolism and respiration			P64264					X2BH98,P64264					Rv1279		Rv1279			
NC_002945.3	Mycobrowser_v4	CDS	1443107	1443421	.	+	0	Mb1322	Mb1322		HYPOTHETICAL PROTEIN	Mb1322, -, len: 104 aa. Equivalent to Rv1290A, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 104 aa overlap). Hypothetical unknown protein, equivalent to AAK45590 from Mycobacterium tuberculosis strain CDC1551 (122 aa) but shorter 18 aa.	Q7U087,A0A1R3XY94	No	conserved hypotheticals			A0A1R3XY94					Q7U087					Rv1290A		Rv1290A			
NC_002945.3	Mycobrowser_v4	CDS	1441531	1443096	.	-	0	Mb1321c	Mb1321c		conserved protein	Mb1321c, -, len: 521 aa. Equivalent to Rv1290c,len: 521 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 521 aa overlap). Conserved hypothetical protein, similar to AL031013|SC8A6.09 hypothetical protein from Streptomyces coelicolor (443 aa), FASTA scores: opt: 371, E(): 9.5e-17, (28.3% identity in 446 aa overlap).	X2BHN2,P0A5E4,P0A5E4	No	conserved hypotheticals			P0A5E4					X2BHN2,P0A5E4					Rv1290c		Rv1290c			
NC_002945.3	Mycobrowser_v4	CDS	1466924	1467541	.	-	0	Mb1346c	Mb1346c		POSSIBLE TRANSPOSASE [FIRST PART]	Mb1346c, -, len: 205 aa. Equivalent to 5' end of Rv1313c, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 195 aa overlap). Possible IS1557 transposase, similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase for insertion sequence element IS1001 from Bordetella parapertussis (406 aa), FASTA scores: opt: 254, E(): 3.3e-10, (24.9% identity in 402 aa overlap). Also similar to putative Mycobacterium tuberculosis transposases,Rv3798 and Rv0741. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts, Mb1345c and Mb1346c.	Q7TTK1,A0A0G2QBZ2	No				A0A0G2QBZ2				IPR002560	Q7TTK1										
NC_002945.3	Mycobrowser_v4	CDS	1438951	1439436	.	+	0	Mb1318	Mb1318		CONSERVED HYPOTHETICAL PROTEIN	Mb1318, -, len: 161 aa. Equivalent to Rv1287, len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 161 aa overlap). Conserved hypothetical protein, similar to VJEB family of proteins e.g. FASTA score: P44675|Y379_HAEIN HYPOTHETICAL PROTEIN HI0379 (150 aa), FASTA scores: opt: 213, E(): 2.5e-08, (30.0% identity in 130 aa overlap) and YJEB_ECOLI|P21498 hypothetical 15.6 kd protein in pura-vacb (141 aa), opt: 167, E(): 9.5e-06,(25.0% identity in 136 aa overlap). BELONGS TO THE UPF0074 (RFF2) FAMILY.	X2BHW4,P67160,P67160	No	conserved hypotheticals			P67160					X2BHW4,P67160					Rv1287		Rv1287			
NC_002945.3	Mycobrowser_v4	CDS	1439494	1440711	.	+	0	Mb1319	Mb1319		conserved protein	Mb1319, -, len: 405 aa. Similar to Rv1288, len: 456 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 403 aa overlap). Conserved hypothetical protein, some similarity to A85B_MYCTU|P31952 antigen 85-b precursor (85b) (325 aa), FASTA scores: opt: 199, E(): 2.7e-06, (24.7% identity in 279 aa overlap). Also similar to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related to antigen 85 complex) from Corynebacterium glutamicum (657 aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa).	Q7U088,A0A1R3Y024	No				A0A1R3Y024				IPR000801,IPR008861,IPR018392	Q7U088										
NC_002945.3	Mycobrowser_v4	CDS	1440760	1441392	.	+	0	Mb1320	Mb1320		unknown protein	Mb1320, -, len: 210 aa. Equivalent to Rv1289, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Hypothetical unknown protein.	X2BHA6,P64800	No	conserved hypotheticals			P64800					X2BHA6					Rv1289		Rv1289			
NC_002945.3	Mycobrowser_v4	CDS	1531983	1532645	.	-	0	Mb1397c	Mb1397c		POSSIBLE MEMBRANE PROTEIN	Mb1397c, -, len: 220 aa. Equivalent to Rv1362c,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 220 aa overlap). Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc.	Q7U070,A0A1R3XY64	No	cell wall and cell processes			A0A1R3XY64					Q7U070					Rv1362c		Rv1362c			
NC_002945.3	Mycobrowser_v4	CDS	1457815	1458300	.	+	0	Mb1335	Mb1335		CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN	Mb1335, -, len: 161 aa. Equivalent to Rv1303, len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 161 aa overlap). Conserved hypothetical transmembrane protein, highly similar to P53431|Y02N_MYCLE hypothetical Mycobacterium leprae protein (153 aa), FASTA score: opt: 636, E():0, (69.8% identity in 149 aa overlap).	X2BHB8,P64802,P64802	No	cell wall and cell processes			P64802					X2BHB8,P64802					Rv1303		Rv1303			
NC_002945.3	Mycobrowser_v4	CDS	1938610	1939179	.	+	0	Mb1756	Mb1756		CONSERVED HYPOTHETICAL PROTEIN	Mb1756, -, len: 189 aa. Equivalent to Rv1727, len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 189 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins P72040|Rv3773c|MTCY13D12.07C (194 aa), FASTA scores: opt: 176, E(): 2.7e-08, (31.1% identity in 180 aa overlap); and O53801|Rv0738 (182 aa).	Q7TZP7,A0A1R3XZ63	No	conserved hypotheticals			A0A1R3XZ63				IPR017517,IPR017520,IPR024344	Q7TZP7					Rv1727		Rv1727			
NC_002945.3	Mycobrowser_v4	CDS	1466218	1466949	.	-	0	Mb1345c	Mb1345c		POSSIBLE TRANSPOSASE [SECOND PART]	Mb1345c, -, len: 243 aa. Equivalent to 3' end of Rv1313c, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 243 aa overlap). Possible IS1557 transposase, similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase for insertion sequence element IS1001 from Bordetella parapertussis (406 aa), FASTA scores: opt: 254, E(): 3.3e-10, (24.9% identity in 402 aa overlap). Also similar to putative Mycobacterium tuberculosis transposases,Rv3798 and Rv0741. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts, Mb1345c and Mb1346c.	Q7TTF3,UPI00001A8FCC	No				UPI00001A8FCC				IPR002560	Q7TTF3										
NC_002945.3	Mycobrowser_v4	CDS	1467707	1468288	.	-	0	Mb1347c	Mb1347c		conserved protein	Mb1347c, -, len: 193 aa. Equivalent to Rv1314c,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 193 aa overlap). Conserved hypothetical protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kd protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa),FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap).	X2BHJ1,P64804,P64804	No	conserved hypotheticals			P64804					X2BHJ1,P64804					Rv1314c		Rv1314c			
NC_002945.3	Mycobrowser_v4	CDS	1483348	1483806	.	-	0	Mb1357c	Mb1357c		conserved protein	Mb1357c, -, len: 152 aa. Equivalent to Rv1322A,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 152 aa overlap). Conserved hypothetical protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. AL583921_2|ML1157 from M. leprae strain TN (155 aa), FASTA scores: opt: 771, E(): 5.1e-43, (75.3% identity in 154 aa overlap); and AL137242_2 from S. coelicolor (146 aa), FASTA scores: opt: 404, E(): 2e-19, (43.165% identity in 139 aa overlap).	Q7U080,A0A1R3XY23	No	conserved hypotheticals			A0A1R3XY23				IPR017515	Q7U080					Rv1322A		Rv1322A			
NC_002945.3	Mycobrowser_v4	CDS	1477234	1478859	.	-	0	Mb1352c	Mb1352c		POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)	Mb1352c, -, len: 541 aa. Equivalent to Rv1318c,len: 541 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 541 aa overlap). Possible adenylate cyclase (EC 4.6.1.1). Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11,(28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505,E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423,E(): 0, (68.7% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.	X2BHJ8,P63528,P63528	No	intermediary metabolism and respiration			P63528					X2BHJ8,P63528					Rv1318c		Rv1318c			
NC_002945.3	Mycobrowser_v4	CDS	1478929	1480536	.	-	0	Mb1353c	Mb1353c		POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)	Mb1353c, -, len: 535 aa. Equivalent to Rv1319c,len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 535 aa overlap). Possible adenylate cyclase (EC 4.6.1.1). Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores: opt: 254, E(): 2.4e-10,(33.3% identity in 144 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505,E(): 0, (71.0% identity in 534 aa overlap); Rv1320c|MTCY130.05c (567 aa), FASTA scores: opt: 2354,E(): 0, (66.3% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.	X2BI01,P0A4Y3,P0A4Y3	No	intermediary metabolism and respiration			P0A4Y3					X2BI01,P0A4Y3					Rv1319c		Rv1319c			
NC_002945.3	Mycobrowser_v4	CDS	1480549	1482252	.	-	0	Mb1354c	Mb1354c		POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)	Mb1354c, -, len: 567 aa. Equivalent to Rv1320c,len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 567 aa overlap). Possible adenylate cyclase (EC 4.6.1.1) (see second citation below). Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores: opt: 277, E(): 2e-12, (34.0% identity in 156 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2423, E(): 0, (68.7% identity in 534 aa overlap); Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2354, E(): 0, (66.3% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.	X2BHL2,P59972,P59972	No	intermediary metabolism and respiration			P59972					X2BHL2,P59972					Rv1320c		Rv1320c			
NC_002945.3	Mycobrowser_v4	CDS	1482314	1482994	.	+	0	Mb1355	Mb1355		CONSERVED HYPOTHETICAL PROTEIN	Mb1355, -, len: 226 aa. Equivalent to Rv1321, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Conserved hypothetical protein. Equivalent to P53524|YD21_MYCLE hypothetical protein from Mycobacterium leprae (201 aa), FASTA scores: opt: 1144, E(): 0, (87.6% identity in 193 aa overlap). Some similarity to hypothetical proteins from other organisms e.g. Y225_METJA|Q57678 Methanococcus jannaschii (263 aa), FASTA scores: E(): 6.5e-05, (25.0% identity in 212 aa overlap).	X2BHD3,P59979,P59979	No	conserved hypotheticals			P59979					X2BHD3,P59979					Rv1321		Rv1321			
NC_002945.3	Mycobrowser_v4	CDS	1483017	1483313	.	+	0	Mb1356	Mb1356		CONSERVED HYPOTHETICAL PROTEIN	Mb1356, -, len: 98 aa. Equivalent to Rv1322, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 98 aa overlap). Conserved hypothetical protein.	X2BHR5,P64806	No	conserved hypotheticals			P64806					X2BHR5					Rv1322		Rv1322			
NC_002945.3	Mycobrowser_v4	CDS	1485196	1486110	.	+	0	Mb1359	Mb1359		POSSIBLE THIOREDOXIN	Mb1359, -, len: 304 aa. Equivalent to Rv1324, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 304 aa overlap). Possible thioredoxin (EC 1.-.-.-), similar to several e.g. U00014|Q49716 TRXA from Mycobacterium leprae (255 aa), FASTA scores: opt: 1014, E(): 0, (69.7% identity in 228 aa overlap); THIO_RHOSH|P08058 TrxA from Rhodobacter sphaeroides (105 aa), FASTA scores: opt 196, E(): 1.9e-06, (33.0% identity in 103 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.	X2BHL7,P64808,P64808	No	intermediary metabolism and respiration			P64808					X2BHL7,P64808					Rv1324		Rv1324			
NC_002945.3	Mycobrowser_v4	CDS	1498696	1499001	.	+	0	Mb1366	Mb1366		CONSERVED HYPOTHETICAL PROTEIN	Mb1366, -, len: 101 aa. Equivalent to Rv1331, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 101 aa overlap). Conserved hypothetical protein, highly similar to U00014|ML014 B1549_C2_207 from Mycobacterium leprae (94 aa), FASTA scores: opt: 573, E(): 2.9e-40, (90.3% identity in 93 aa overlap). Similar to AL096852|SCE19A_16 hypothetical protein from Streptomyces coelicolor (105 aa), FASTA scores: opt: 377, E(): 2.9e-22,(60.0% identity in 105 aa overlap).	X2BHT0,P67648,P67648	No	conserved hypotheticals			P67648					X2BHT0,P67648					Rv1331		Rv1331			
NC_002945.3	Mycobrowser_v4	CDS	1498961	1499617	.	+	0	Mb1367	Mb1367		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1367, -, len: 218 aa. Equivalent to Rv1332, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 218 aa overlap). Possible regulatory protein, high similarity to ML014|U00014 from Mycobacterium leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E(): 0, (75.6% identity in 221 aa overlap). Helix turn helix motif fram aa 8-29 (+3.03 SD).	X2BHL1,P64810	No	regulatory proteins			P64810					X2BHL1					Rv1332		Rv1332			
NC_002945.3	Mycobrowser_v4	CDS	1499634	1500668	.	+	0	Mb1368	Mb1368		PROBABLE HYDROLASE	Mb1368, -, len: 344 aa. Equivalent to Rv1333, len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 344 aa overlap). Possible hydrolase (EC 3.-.-.-), similar to Q57326|D26094 endo-type 6-aminohexanoate oligomer hydrolase (355 aa), fasta scores: E(): 1.4e-10, (31.9% identity in 339 aa overlap). Equivalent to P53425|YD33_MYCLE HYPOTHETICAL 36.1 KD PROTEIN B154 Mycobacterium leprae (362 aa), FASTA scores: opt: 1735, E(): 0, (76.7% identity in 352 aa overlap).	X2BI21,P64812,P64812	No	intermediary metabolism and respiration			P64812					X2BI21,P64812					Rv1333		Rv1333			
NC_002945.3	Mycobrowser_v4	CDS	1503952	1504773	.	+	0	Mb1374	Mb1374		conserved protein	Mb1374, -, len: 273 aa. Equivalent to Rv1339, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Conserved hypothetical protein, highly similar to Y211_MYCLE|P50474 hypothetical protein b1549_c2_211 from Mycobacterium leprae (284 aa),FASTA scores: opt: 1672, E(): 0, (86.2% identity in 276 aa overlap). Also similar to AL096852|SCE19A.08 hypothetical protein from Streptomyces coelicolor (250 aa), FASTA scores: opt: 630, E(): 0, (42.2% identity in 256 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins Rv3796, Rv2407.	X2BHN1,P66874,P66874	No	conserved hypotheticals			P66874					X2BHN1,P66874					Rv1339		Rv1339			
NC_002945.3	Mycobrowser_v4	CDS	1532642	1533427	.	-	0	Mb1398c	Mb1398c		POSSIBLE MEMBRANE PROTEIN	Mb1398c, -, len: 261 aa. Equivalent to Rv1363c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 261 aa overlap). Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv1362c|MTCY02B10.26c (25.9% identity in 216 aa overlap ); Rv1972|MTV051.10 and Rv0177 etc.	Q7U069,A0A1R3XY48	No	cell wall and cell processes			A0A1R3XY48					Q7U069					Rv1363c		Rv1363c			
NC_002945.3	Mycobrowser_v4	CDS	1505608	1506222	.	+	0	Mb1376	Mb1376		conserved protein	Mb1376, -, len: 204 aa. Equivalent to Rv1341, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 204 aa overlap). Conserved hypothetical protein, equivalent to ML014|U00014 hypothetical protein B1549_C2_213 from Mycobacterium leprae (285 aa), FASTA scores: opt: 1073, E(): 0, (83.0% identity in 206 aa overlap). Some similarity to P52061|YGGV_ECOLI HYPOTHETICAL PROTEIN yggV (197 aa), FASTA scores: opt: 521, E(): 7.9e-27, (46.0% identity in 200 aa overlap).	X2BHU2,P64308,P64308	No	conserved hypotheticals			P64308					X2BHU2,P64308					Rv1341		Rv1341			
NC_002945.3	Mycobrowser_v4	CDS	1541503	1542684	.	+	0	Mb1406	Mb1406		CONSERVED HYPOTHETICAL PROTEIN	Mb1406, -, len: 393 aa. Equivalent to Rv1372, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Conserved hypothetical protein, similar to several chalcone synthases e.g. CHS2_GERHY|P48391 chalcone synthase 2 from gerbra hybrid (402 aa), FASTA scores: opt: 511, E(): 7e-26, (28.4% identity in 380 aa overlap). Also similar to M. tuberculosis hypothetical chalcone synthases, Rv1665,Rv1660.	X2BHP7,Q7U064,Q7U064	No	conserved hypotheticals			Q7U064					X2BHP7,Q7U064					Rv1372		Rv1372			
NC_002945.3	Mycobrowser_v4	CDS	1694746	1695015	.	+	0	Mb1546	Mb1546		CONSERVED HYPOTHETICAL PROTEIN	Mb1546, -, len: 89 aa. Equivalent to Rv1519, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 89 aa overlap). Conserved hypothetical protein, high similarity to C-terminus of Q50723|MTCY78.26|Rv3402c (412 aa) (58.1% identity in 74 aa overlap).	X2BI40,P64862,P64862	No	conserved hypotheticals			P64862					X2BI40,P64862					Rv1519		Rv1519			
NC_002945.3	Mycobrowser_v4	CDS	1517235	1518020	.	-	0	Mb1388c	Mb1388c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1388c, -, len: 261 aa. Equivalent to Rv1353c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Probable transcriptional regulatory protein, similar to TER1_ECOLI|P03038 tetracycline repressor protein class A from Escherichia coli (216 aa), FASTA scores, opt: 231,E(): 1.6e-08, (31.3% identity in 211 aa overlap). Helix turn helix motif present at aa 3859 (+3.59 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	X2BI41,P67435,P67435	No	regulatory proteins			P67435					X2BI41,P67435					Rv1353c		Rv1353c			
NC_002945.3	Mycobrowser_v4	CDS	1518040	1519911	.	-	0	Mb1389c	Mb1389c		CONSERVED HYPOTHETICAL PROTEIN	Mb1389c, -, len: 623 aa. Equivalent to Rv1354c,len: 623 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 623 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins e.g. the C-terminus of G1001455 Synechocystis sp. (1244 aa), FASTA scores: opt: 933, E(): 0, (36.8% identity in 462 aa overlap); also similar to Rv1357c|MTCY02B10.21c (34.0% identity in 253 aa overlap).	X2BHP2,P64826,P64826	No	conserved hypotheticals			P64826					X2BHP2,P64826					Rv1354c		Rv1354c			
NC_002945.3	Mycobrowser_v4	CDS	1522064	1522855	.	-	0	Mb1391c	Mb1391c		HYPOTHETICAL PROTEIN	Mb1391c, -, len: 263 aa. Equivalent to Rv1356c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 263 aa overlap). Hypothetical unknown protein.	X2BHV6,P64828	No	conserved hypotheticals			P64828					X2BHV6					Rv1356c		Rv1356c			
NC_002945.3	Mycobrowser_v4	CDS	1523328	1524251	.	-	0	Mb1392c	Mb1392c		CONSERVED HYPOTHETICAL PROTEIN	Mb1392c, -, len: 307 aa. Equivalent to Rv1357c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Conserved hypothetical protein, similar to members of the YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical protein Y4ll from Rhizobium sp. (827 aa), FASTA scores: E(): 0, (37.7% identity in 257 aa overlap), also similar to Rv1354c|MTCY02B10.18c (34.0% identity in 253 aa overlap). BELONGS TO THE YEGE/YHDA/YHJK/YJCC FAMILY.	X2BHN5,P64830,P64830	No	conserved hypotheticals			P64830					X2BHN5,P64830					Rv1357c		Rv1357c			
NC_002945.3	Mycobrowser_v4	CDS	1524647	1528126	.	+	0	Mb1393	Mb1393		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1393, -, len: 1159 aa. Equivalent to Rv1358, len: 1159 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 1159 aa overlap). Probable transcriptional regulatory protein, some similarity to AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores: opt: 210,E(): 5.5e-06, (27.5% identity in 739 aa overlap). Similar also to Rv0890C|MTCY31.18c (65.5% identity in 884 aa overlap) and to Rv1359|MTCY02B10.23 (43.7% identity in 197 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, PS00622 Bacterial regulatory proteins, luxR family signature. Helix turn helix motif present at aa 1116-1137,(Score 1291, +3.59 SD).	Q7U073,A0A1R3XYI6	No	regulatory proteins			A0A1R3XYI6				IPR000792,IPR001054,IPR011991,IPR016032,IPR027417	Q7U073					Rv1358		Rv1358			
NC_002945.3	Mycobrowser_v4	CDS	1528208	1528960	.	+	0	Mb1394	Mb1394		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1394, -, len: 250 aa. Equivalent to Rv1359, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap).	Q7U072,A0A1R3XY50	No	regulatory proteins			A0A1R3XY50				IPR001054	Q7U072					Rv1359		Rv1359			
NC_002945.3	Mycobrowser_v4	CDS	1529383	1530405	.	+	0	Mb1395	Mb1395		PROBABLE OXIDOREDUCTASE	Mb1395, -, len: 340 aa. Equivalent to Rv1360, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 340 aa overlap). Probable oxidoreductase (EC 1.-.-.-). Similar to Q49598|G1002714 coenzyme F420-dependent n5, n10-methylenetetrahydromethanopterin reductase from Methanopyrus kandleri (349 aa), FASTA scores: opt: 264, E(): 4.4e-11, (26.3% identity in 323 aa overlap).	X2BHG0,P64832,P64832	No	intermediary metabolism and respiration			P64832					X2BHG0,P64832					Rv1360		Rv1360			
NC_002945.3	Mycobrowser_v4	CDS	1533718	1535679	.	-	0	Mb1399c	Mb1399c		possible sigma factor regulatory protein	Mb1399c, -, len: 653 aa. Equivalent to Rv1364c,len: 653 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 653 aa overlap). Conserved hypothetical protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa),FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 aa overlap).	Q7U068,A0A1R3XY52	No	information pathways			A0A1R3XY52				IPR000014,IPR000700,IPR001610,IPR001932,IPR002645,IPR003594,IPR013656	Q7U068					Rv1364c		Rv1364c			
NC_002945.3	Mycobrowser_v4	CDS	1537547	1538680	.	-	0	Mb1402c	Mb1402c		conserved protein	Mb1402c, -, len: 377 aa. Equivalent to Rv1367c,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 377 aa overlap). Conserved hypothetical protein. Some similarity to penicillin binding proteins e.g. PBPE_BACSU|P32959 penicillin-binding protein 4* (pbp 4*) from Bacillus subtilis (451 aa), FASTA scores: E(): 6.9e-06, (23.6% identity in 373 aa overlap). Similar to AL031107|SC5A7.06 hypothetical protein from Streptomyces coelicolor (409 aa), FASTA scores: opt: 675, E(): 0,(40.4% identity in 339 aa overlap).	Q7U066,A0A1R3XYJ6	No	conserved hypotheticals			A0A1R3XYJ6				IPR001466,IPR012338	Q7U066					Rv1367c		Rv1367c			
NC_002945.3	Mycobrowser_v4	CDS	1686880	1687071	.	-	0	Mb1536c	Mb1536c		conserved protein	Mb1536c, -, len: 63 aa. Equivalent to Rv1498A, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 63 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. from Streptomyces coelicolor, Sinorhizobium meliloti and Pseudomonas aeruginosa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa).	Q7TZY9,A0A1R3XYI0	No	conserved hypotheticals			A0A1R3XYI0				IPR009923,IPR025543	Q7TZY9					Rv1498A		Rv1498A			
NC_002945.3	Mycobrowser_v4	CDS	1540036	1540989	.	+	0	Mb1404	Mb1404		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb1404, -, len: 317 aa. Similar to 5' end of Rv1371, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (90.9% identity in 166 aa overlap). Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052,(22.4% identity in 438 aa overlap); and Homo sapiens. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and Mb1405, with the latter being the more likely product.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1540511	1541506	.	+	0	Mb1405	Mb1405		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb1405, -, len: 331 aa. Equivalent to 3' end of Rv1371, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 331 aa overlap). Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052,(22.4% identity in 438 aa overlap); and Homo sapiens. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and Mb1405, with the latter being the more likely product.	Q7U065,A0A1R3XY54	No				A0A1R3XY54				IPR005804	Q7U065										
NC_002945.3	Mycobrowser_v4	CDS	1542690	1543487	.	+	0	Mb1407	Mb1407		GLYCOLIPID SULFOTRANSFERASE [FIRST PART]	Mb1407, -, len: 265 aa. Equivalent to the 5' end of Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 154 aa overlap). Glycolipid sulfotransferase (EC 2.8.2.-) (see citation below); slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity in 294 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408.	Q7U063,A0A1R3XY57	No				A0A1R3XY57				IPR000863,IPR027417	Q7U063										
NC_002945.3	Mycobrowser_v4	CDS	1543153	1543671	.	+	0	Mb1408	Mb1408		GLYCOLIPID SULFOTRANSFERASE [SECOND PART]	Mb1408, -, len: 172 aa. Equivalent to the 3' end of Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 172 aa overlap). Glycolipid sulfotransferase (EC 2.8.2.-) (see citation below); slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity in 294 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1543751	1544209	.	-	0	Mb1409c	Mb1409c		HYPOTHETICAL PROTEIN	Mb1409c, -, len: 152 aa. Equivalent to Rv1374c,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 152 aa overlap). Hypothetical unknown protein.	Q7U062,A0A1R3XY59	No	conserved hypotheticals			A0A1R3XY59					Q7U062					Rv1374c		Rv1374c			
NC_002945.3	Mycobrowser_v4	CDS	1544511	1545830	.	+	0	Mb1410	Mb1410		CONSERVED HYPOTHETICAL PROTEIN	Mb1410, -, len: 439 aa. Equivalent to Rv1375, len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 439 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. Q52871|U39409 Rhizobium leguminosarum (420 aa), FASTA scores: E(): 2e-30, (34.4% identity in 378 aa overlap).	Q7U061,A0A1R3Y0B5	No	conserved hypotheticals			A0A1R3Y0B5				IPR003776	Q7U061					Rv1375		Rv1375			
NC_002945.3	Mycobrowser_v4	CDS	1545827	1547320	.	+	0	Mb1411	Mb1411		CONSERVED HYPOTHETICAL PROTEIN	Mb1411, -, len: 497 aa. Equivalent to Rv1376, len: 497 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 497 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins from several organisms e.g. Q52872|U39409 Rhizobium leguminosarum (247 aa), FASTA scores: E(): 2.1e-12, (34.7% identity in 219 aa overlap).	Q7U060,A0A1R3XZ59	No	conserved hypotheticals			A0A1R3XZ59				IPR012924,IPR016845	Q7U060					Rv1376		Rv1376			
NC_002945.3	Mycobrowser_v4	CDS	1547258	1547896	.	-	0	Mb1412c	Mb1412c		PUTATIVE TRANSFERASE	Mb1412c, -, len: 212 aa. Equivalent to Rv1377c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 212 aa overlap). Putative transferase (EC 2.-.-.-), similar to YQEM_BACSU|P54458 hypothetical 28.3 kd protein from Bacillus subtilis (247 aa), FASTA scores: opt: 221, E(): 7.6e-08, (30.6% identity in 144 aa overlap); some similarity to methyltransferases, also similar to Mycobacterium tuberculosis hypothetical proteins Rv0560c, Rv3699, and Rv2675c (~ 39.1% identity in 197 aa overlap).	Q7U059,A0A1R3XY67	No	intermediary metabolism and respiration			A0A1R3XY67				IPR013216	Q7U059					Rv1377c		Rv1377c			
NC_002945.3	Mycobrowser_v4	CDS	1547907	1549334	.	-	0	Mb1413c	Mb1413c		CONSERVED HYPOTHETICAL PROTEIN	Mb1413c, -, len: 475 aa. Equivalent to Rv1378c,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 475 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C (424 aa),FASTA scores: E(): 0, (73.0% identity in 429 aa overlap).	Q7U058,A0A1R3XYK4	No	conserved hypotheticals			A0A1R3XYK4				IPR003615,IPR003870	Q7U058					Rv1378c		Rv1378c			
NC_002945.3	Mycobrowser_v4	CDS	1552156	1552653	.	+	0	Mb1417	Mb1417		PROBABLE EXPORT OR MEMBRANE PROTEIN	Mb1417, -, len: 165 aa. Equivalent to Rv1382, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Possible exported or membrane protein, hydrophobic domain at N-terminus.	Q7U056,A0A1R3XY77	No	cell wall and cell processes			A0A1R3XY77					Q7U056					Rv1382		Rv1382			
NC_002945.3	Mycobrowser_v4	CDS	1564788	1566266	.	-	0	Mb1428c	Mb1428c		PROBABLE MONOXYGENASE	Mb1428c, -, len: 492 aa. Equivalent to Rv1393c,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 492 aa overlap). Probable monooxygenase (EC 1.14.13.-), similar to others e.g. CYMO_ACISP|P12015 cyclohexanone monooxygenase (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: E(): 0, (33.0% identity in 473 aa overlap); also to Rv3083|MTCY31.20|E241788 hypothetical 55.0 kDa protein from Mycobacterium tuberculosis (495 aa) (36.3% identity in 490 aa overlap); and Rv0565c, Rv3854c, Rv3049c,Rv0892.	Q7U050,A0A1R3XY79	No	intermediary metabolism and respiration			A0A1R3XY79					Q7U050					Rv1393c		Rv1393c			
NC_002945.3	Mycobrowser_v4	CDS	1575905	1576729	.	-	0	Mb1438c	Mb1438c		PUTATIVE METHYLTRANSFERASE	Mb1438c, -, len: 274 aa. Equivalent to Rv1403c,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Putative methyltransferase (EC 2.1.1.-), similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa), FASTA scores: opt: 217, E(): 1.1e-07, (37.1% identity in 105 aa overlap); similar to Rv1405c|MTCY21B4.22c (59.3% identity in 273 aa overlap) and to Rv1523, Rv2952, etc.	X2BHU0,P64840,P64840	No	intermediary metabolism and respiration			P64840					X2BHU0,P64840					Rv1403c		Rv1403c			
NC_002945.3	Mycobrowser_v4	CDS	1567726	1568760	.	+	0	Mb1430	Mb1430		transcriptional regulatory protein	Mb1430, -, len: 344 aa. Equivalent to Rv1395, len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 344 aa overlap). Probable transcriptional regulatory protein, similar to many e.g. URER_PROMI|Q02458 urease operon transcriptional activator from Proteus mirabilis (293 aa), FASTA scores: E():1.5e-08, (41.7% identity in 84 aa overlap); YHIX_ECOLI|P37639 hypothetical transcriptional regulatory protein from Escherichia coli (274 aa), FASTA scores: opt: 238, E(): 3.5e-09, (27.3% identity in 249 aa overlap); and G296916|X68281 POSSIBLE VIRULENCE-REGULATING protein from Mycobacterium tuberculosis (339 aa), FASTA scores: opt: 228, E(): 1.9e-08, (27.0% identity in 278 aa overlap). Helix turn helix motif present, aa 261-282 (+4.68 SD). BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. 3' part corrected since first submission (-14 aa).	X2BHZ0,P68912,P68912	No	regulatory proteins			P68912					X2BHZ0,P68912					Rv1395		Rv1395			
NC_002945.3	Mycobrowser_v4	CDS	1573237	1573839	.	+	0	Mb1436	Mb1436		POSSIBLE MEMBRANE PROTEIN	Mb1436, -, len: 200 aa. Equivalent to Rv1401, len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 200 aa overlap). Possible membrane protein.	X2BHS7,P64838,P64838	No	cell wall and cell processes			P64838					X2BHS7,P64838					Rv1401		Rv1401			
NC_002945.3	Mycobrowser_v4	CDS	1577452	1578276	.	-	0	Mb1440c	Mb1440c		PUTATIVE METHYLTRANSFERASE	Mb1440c, -, len: 274 aa. Equivalent to Rv1405c,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Putative methyltransferase (EC 2.1.1.-), most similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa), FASTA scores: opt: 219, E(): 2.6e-07, (29.9% identity in 144 aa overlap); similar to Rv1403c|MTCY21B4.20c (59.3% identity in 273 aa overlap),Rv1523, Rv2952, etc.	X2BI04,P64842,P64842	No	intermediary metabolism and respiration			P64842					X2BI04,P64842					Rv1405c		Rv1405c			
NC_002945.3	Mycobrowser_v4	CDS	1595200	1595961	.	-	0	Mb1459c	Mb1459c		POSSIBLE MEMBRANE PROTEIN	Mb1459c, -, len: 253 aa. Equivalent to Rv1424c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 253 aa overlap). Possible membrane protein, contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.	X2BHK9,P64852	No	cell wall and cell processes			P64852					X2BHK9					Rv1424c		Rv1424c			
NC_002945.3	Mycobrowser_v4	CDS	1582517	1584073	.	-	0	Mb1445c	Mb1445c		AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL MEMBRANE PROTEIN	Mb1445c, -, len: 518 aa. Equivalent to Rv1410c,len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 518 aa overlap). Aminoglycoside/tetracycline-transport integral membrane protein (see citation below), member of major facilitator superfamily (MFS), similar to others e.g. AC22_STRCO|P46105 probable actinorhodin transporter from Streptomyces coelicolor (578 aa), FASTA scores: opt: 442,E(): 4.9e-21, (28.5% identity in 466 aa overlap); etc. Contains PS00216 Sugar transport proteins signature 1. Could be termed P55. Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in M. bovis BCG (see second citation).	X2BI12,Q7U042,Q7U042	No	cell wall and cell processes			Q7U042					X2BI12,Q7U042					Rv1410c		Rv1410c			
NC_002945.3	Mycobrowser_v4	CDS	1585693	1586208	.	+	0	Mb1448	Mb1448		CONSERVED HYPOTHETICAL PROTEIN	Mb1448, -, len: 171 aa. Equivalent to Rv1413, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Conserved hypothetical protein, similar to part of AB010956|AB010956_1 metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA scores: opt: 187, E(): 0.00026, (29.0% identity in 162 aa overlap).	X2BHV2,P64844	No	conserved hypotheticals			P64844					X2BHV2					Rv1413		Rv1413			
NC_002945.3	Mycobrowser_v4	CDS	1586198	1586599	.	+	0	Mb1449	Mb1449		CONSERVED HYPOTHETICAL PROTEIN	Mb1449, -, len: 133 aa. Equivalent to Rv1414, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 133 aa overlap). Conserved hypothetical protein, similar to C-terminal part of AB010956|AB010956_1 novel metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA scores: opt: 163, E(): 0.00063, (32.1% identity in 112 aa overlap). Rv1413 is similar to N-terminal part of same enzyme suggesting possible frameshift. Sequence has been checked and no errors found,it is identical in Mycobacterium tuberculosis CDC1551.	X2BHJ9,P64846	No	conserved hypotheticals			P64846					X2BHJ9					Rv1414		Rv1414			
NC_002945.3	Mycobrowser_v4	CDS	1595965	1597344	.	+	0	Mb1460	Mb1460		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb1460, -, len: 459 aa. Equivalent to Rv1425, len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 459 aa overlap). Conserved hypothetical protein, similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv3740c, Rv3734c, Rv1760, etc.	Q7U039,A0A1R3Y0E4	No	lipid metabolism			A0A1R3Y0E4				IPR004255,IPR014292	Q7U039					Rv1425		Rv1425			
NC_002945.3	Mycobrowser_v4	CDS	1588457	1588921	.	+	0	Mb1452	Mb1452		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb1452, -, len: 154 aa. Equivalent to Rv1417, len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212,E(): 4.4e-07, (32.4% identity in 136 aa overlap).	X2BI99,P64848,P64848	No	cell wall and cell processes			P64848					X2BI99,P64848					Rv1417		Rv1417			
NC_002945.3	Mycobrowser_v4	CDS	1592286	1593191	.	+	0	Mb1456	Mb1456		conserved protein	Mb1456, -, len: 301 aa. Equivalent to Rv1421, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins e.g. YHBJ_ECOLI|P33995 hypothetical 32.5 kd protein from Escherichia coli (284 aa), FASTA scores: opt: 648, E(): 6.3e-36, (38.7% identity in 282aa overlap).	X2BHV1,P67107,P67107	No	conserved hypotheticals			P67107					X2BHV1,P67107					Rv1421		Rv1421			
NC_002945.3	Mycobrowser_v4	CDS	1593188	1594216	.	+	0	Mb1457	Mb1457		CONSERVED HYPOTHETICAL PROTEIN	Mb1457, -, len: 342 aa. Equivalent to Rv1422, len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 342 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins e.g. YAMB_THETU|P38541 Thermoanaerobacterium thermosulfurigenes (323 aa), FASTA scores: opt: 519, E(): 1.6e-25, (33.1% identity in 320 aa overlap); and AF106003|AF106003_3 Streptomyces coelicolor (363 aa), FASTA scores: opt: 1047,E(): 0, (54.5% identity in 308 aa overlap).	Q7U041,A0A1R3XYB6	No	conserved hypotheticals			A0A1R3XYB6				IPR002882,IPR010119	Q7U041					Rv1422		Rv1422			
NC_002945.3	Mycobrowser_v4	CDS	1687153	1687551	.	+	0	Mb1537	Mb1537		HYPOTHETICAL PROTEIN	Mb1537, -, len: 132 aa. Equivalent to Rv1499, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 132 aa overlap). Hypothetical unknown protein, was initially longer but has been shortened owing to overlap with Rv1498A.	Q7TZY8,A0A1R3XYJ5	No	conserved hypotheticals			A0A1R3XYJ5					Q7TZY8					Rv1499		Rv1499			
NC_002945.3	Mycobrowser_v4	CDS	1601185	1602453	.	+	0	Mb1464	Mb1464		conserved protein	Mb1464, -, len: 422 aa. Equivalent to Rv1429, len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 422 aa overlap). Conserved hypothetical protein, some similarity to transcriptional regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate diacid regulator from Escherichia coli (391 aa), FASTA scores: opt: 210, E(): 3e-06, (27.7% identity in 296 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2370c, Rv1194c, Rv1453, Rv2242, and Rv1186c.	Q7U035,A0A1R3XYC5	No	conserved hypotheticals			A0A1R3XYC5				IPR025736	Q7U035					Rv1429		Rv1429			
NC_002945.3	Mycobrowser_v4	CDS	1604390	1606159	.	+	0	Mb1466	Mb1466		CONSERVED MEMBRANE PROTEIN	Mb1466, -, len: 589 aa. Equivalent to Rv1431, len: 589 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 589 aa overlap). Conserved membrane protein, shows strong similarity to another M. tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2% identity in 585 aa overlap).	Q7U033,A0A1R3XYB1	No	cell wall and cell processes			A0A1R3XYB1				IPR021941	Q7U033					Rv1431		Rv1431			
NC_002945.3	Mycobrowser_v4	CDS	1606156	1607577	.	+	0	Mb1467	Mb1467		PROBABLE DEHYDROGENASE	Mb1467, -, len: 473 aa. Equivalent to Rv1432, len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 473 aa overlap). Probable dehydrogenase (EC 1.-.-.-), shows strong simlarity to P49_STRLI|P06108 p49 protein from Streptomyces lividans (469 aa), FASTA scores: opt: 1362, E(): 0, (44.9% identity in 474 aa overlap); and weak simlarity to other dehydrogenases.	Q7U032,A0A1R3XYC4	No	intermediary metabolism and respiration			A0A1R3XYC4					Q7U032					Rv1432		Rv1432			
NC_002945.3	Mycobrowser_v4	CDS	1607741	1608556	.	+	0	Mb1468	Mb1468		POSSIBLE CONSERVED EXPORTED PROTEIN	Mb1468, -, len: 271 aa. Equivalent to Rv1433, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 271 aa overlap). Possible exported protein with N-terminal signal sequence, highly similar to Q49706 hypothetical protein from Mycobacterium leprae (271 aa), FASTA scores: opt: 1341, E(): 0, (68.3% identity in 271 aa overlap). Also shows similarity to Mycobacterium tuberculosis lipoprotein Rv2518c|MTV009.03c lppS (408 aa) (40.0% identity in 230 aa overlap); and others e.g. Rv0116c, Rv0192, Rv2518c, Rv0483.	Q7U031,A0A1R3XYB7	No	cell wall and cell processes			A0A1R3XYB7				IPR005490	Q7U031					Rv1433		Rv1433			
NC_002945.3	Mycobrowser_v4	CDS	1608563	1608700	.	+	0	Mb1469	Mb1469		HYPOTHETICAL PROTEIN	Mb1469, -, len: 45 aa. Equivalent to Rv1434, len: 45 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 45 aa overlap). Hypothetical unknown protein.	Q7U030,A0A1R3XYB2	No	conserved hypotheticals			A0A1R3XYB2					Q7U030					Rv1434		Rv1434			
NC_002945.3	Mycobrowser_v4	CDS	1608649	1609278	.	-	0	Mb1470c	Mb1470c		Probable conserved Proline, Glycine, Valine-rich secreted protein	Mb1470c, -, len: 209 aa. Highly similar to Rv1435c,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(96.2% identity in 209 aa overlap). Probable conserved Pro-, Gly-, Val-rich secreted protein (see citation below) with a N-terminal signal sequence. Similar at C-terminus to AF017099|AF017099_1 Mycobacterium tuberculosis pGB1 (87 aa), FASTA scores: opt: 550, E(): 2.3e-17, (97.7% identity in 86 aa overlap). Shows some similarity to N-terminus of CPN_DROME|Q02910 calphotin. drosophila melanogaster (865 aa), FASTA scores: opt: 266, E(): 2.5e-05, (37.2% identity in 191 aa overlap). Contains at least five 7 aa imperfect repeats. Also shows similarity to other Mycobacterium tuberculosis proteins e.g. MTCI237.20c (34.7% identity in 193 aa overlap), MTCI65.25c (36.9% identity in 160 aa overlap) and MTCI65.24c (34.2% identity in 196 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa).	Q7U029,A0A1R3Y0G3	No				A0A1R3Y0G3					Q7U029										
NC_002945.3	Mycobrowser_v4	CDS	4017808	4018002	.	-	0	Mb3666c	Mb3666c		HYPOTHETICAL PROTEIN	Mb3666c, -, len: 64 aa. Equivalent to Rv3642c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Hypothetical unknown protein.	Q7TW19	No	conserved hypotheticals								Q7TW19	A0A1R3Y4S5				Rv3642c		Rv3642c			
NC_002945.3	Mycobrowser_v4	CDS	1638239	1639171	.	-	0	Mb1491c	Mb1491c		PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER	Mb1491c, -, len: 310 aa. Equivalent to Rv1456c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 310 aa overlap). Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.34 from Mycobacterium leprae (311 aa),FASTA scores: opt: 1607, E(): 0, (83.3% identity in 300 aa overlap).	Q7U016,A0A1R3XZD6	No	cell wall and cell processes			A0A1R3XZD6				IPR003780	Q7U016					Rv1456c		Rv1456c			
NC_002945.3	Mycobrowser_v4	CDS	1618535	1619020	.	-	0	Mb1478c	Mb1478c		unknown protein	Mb1478c, -, len: 161 aa. Equivalent to Rv1443c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 161 aa overlap). Hypothetical unknown protein.	Q7U025,A0A1R3XYC2	No	conserved hypotheticals			A0A1R3XYC2				IPR019587,IPR023393	Q7U025					Rv1443c		Rv1443c			
NC_002945.3	Mycobrowser_v4	CDS	1675688	1675918	.	+	0	Mb1526	Mb1526		CONSERVED HYPOTHETICAL PROTEIN	Mb1526, -, len: 76 aa. Equivalent to Rv1489A, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 76 aa overlap). Conserved hypothetical protein, similar to part of alpha subunit of many methylmalonyl-CoA mutases (~750 aa). Size difference suggests possible gene fragment although Mycobacterium tuberculosis has intact methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU PROBABLE METHYLMALONYL-COA MUTASE from Mycobacterium tuberculosis (750 aa), FASTA scores: opt: 258, E(): 3.2e-10, (73.35% identity in 60 aa overlap). ORF predicted by GC plot.	Q7TZZ2,A0A1R3XYH1	No	conserved hypotheticals			A0A1R3XYH1				IPR006099	Q7TZZ2					Rv1489A		Rv1489A			
NC_002945.3	Mycobrowser_v4	CDS	1990514	1990873	.	+	0	Mb1796	Mb1796		conserved protein	Mb1796, -, len: 119 aa. Equivalent to Rv1767, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Conserved hypothetical protein, similar to Q57498|YA53_HAEIN HYPOTHETICAL PROTEIN HI1053 from Haemophilus influenzae (113 aa), FASTA scores: opt: 233, E(): 6.4e-10, (40.0% identity in 90 aa overlap).	Q7TZL1,A0A1R3XZ98	No	conserved hypotheticals			A0A1R3XZ98				IPR003779,IPR004675	Q7TZL1					Rv1767		Rv1767			
NC_002945.3	Mycobrowser_v4	CDS	1944640	1945188	.	-	0	Mb1761c	Mb1761c		conserved protein	Mb1761c, -, len: 182 aa. Equivalent to Rv1732c,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 182 aa overlap). Conserved hypothetical protein, highly similar to hypothetical proteins from several organisms e.g. P73178|SLL1289|D90904 from Synechocystis (194 aa), FASTA scores: opt: 663, E(): 0,(53.1% identity in 179 aa overlap); etc.	Q7TZP2,A0A1R3XZZ8	No	conserved hypotheticals			A0A1R3XZZ8				IPR000866,IPR012336	Q7TZP2					Rv1732c		Rv1732c			
NC_002945.3	Mycobrowser_v4	CDS	1635127	1636392	.	+	0	Mb1488	Mb1488		POSSIBLE TRANSCRIPTIONAL ACTIVATOR PROTEIN	Mb1488, -, len: 421 aa. Equivalent to Rv1453, len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 421 aa overlap). Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa).	Q7U019,A0A1R3XYD2	No	regulatory proteins			A0A1R3XYD2				IPR025736	Q7U019					Rv1453		Rv1453			
NC_002945.3	Mycobrowser_v4	CDS	1637426	1638289	.	+	0	Mb1490	Mb1490		conserved protein	Mb1490, -, len: 287 aa. Equivalent to Rv1455, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 287 aa overlap). Conserved hypothetical protein, some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08,(51.3% identity in 78 aa overlap).	Q7U017,A0A1R3Y0I3	No	conserved hypotheticals			A0A1R3Y0I3					Q7U017					Rv1455		Rv1455			
NC_002945.3	Mycobrowser_v4	CDS	1639283	1640068	.	-	0	Mb1492c	Mb1492c		PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER	Mb1492c, -, len: 261 aa. Equivalent to Rv1457c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.32 from Mycobacterium leprae (265 aa),FASTA scores: opt: 1415, E(): 0, (83.1% identity in 260 aa overlap).	Q7U015,A0A1R3XYE5	No	cell wall and cell processes			A0A1R3XYE5				IPR000412,IPR004377	Q7U015					Rv1457c		Rv1457c			
NC_002945.3	Mycobrowser_v4	CDS	1640065	1641006	.	-	0	Mb1493c	Mb1493c		PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1493c, -, len: 313 aa. Equivalent to Rv1458c,len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 313 aa overlap). Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.31 from Mycobacterium leprae (315 aa), FASTA scores: opt: 1812,E(): 0, (88.0% identity in 308 aa overlap). Similar to AF027770|AF027770_7 ABC-type transporter in FxbA region in Mycobacterium smegmatis (284 aa), FASTA scores: opt: 1412,E(): 0, (85.1% identity in 248 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7U014,A0A1R3XYT3	No	cell wall and cell processes			A0A1R3XYT3				IPR003439,IPR003593,IPR017871,IPR027417	Q7U014					Rv1458c		Rv1458c			
NC_002945.3	Mycobrowser_v4	CDS	1641109	1642884	.	-	0	Mb1494c	Mb1494c		POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb1494c, -, len: 591 aa. Equivalent to Rv1459c,len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 591 aa overlap). Possible conserved integral membrane protein, equivalent to MLCL536.30|Z99125 hypothetical protein from Mycobacterium leprae (593 aa),FASTA scores: opt: 1670, E(): 0, (78.6% identity in 585 aa overlap). Also similar to Mycobacterium tuberculosis protein Rv2174|MTV021.07 (33.1% identity in 523 aa overlap).	Q7U013,A0A1R3XYF9	No	cell wall and cell processes			A0A1R3XYF9					Q7U013					Rv1459c		Rv1459c			
NC_002945.3	Mycobrowser_v4	CDS	1642932	1643738	.	+	0	Mb1495	Mb1495		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1495, -, len: 268 aa. Equivalent to Rv1460, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 268 aa overlap). Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 -89. Start changed since original submission.	Q7U012,A0A1R3XYF5	No	regulatory proteins			A0A1R3XYF5				IPR011991	Q7U012					Rv1460		Rv1460			
NC_002945.3	Mycobrowser_v4	CDS	1643735	1646275	.	+	0	Mb1496	Mb1496		conserved protein	Mb1496, -, len: 846 aa. Equivalent to Rv1461, len: 846 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 846 aa overlap). Conserved hypothetical protein. Equivalent of spliced protein from Mycobacterium leprae MLCL536.28c len: 869. Residues 1-253 represent N-extein, and 613-846 the C-extein. The intein present from residues 254 - 612 is different in sequence and site of the insertion from the one present in MLCL536.28c. FASTA scores: Z99125|MLCL536_23 Mycobacterium leprae cosmid L536 (869 aa), opt: 1498 E(): 0, (54.1% identity in 917 aa overlap). The mature protein is similar to Z99120|BSUB0017_150 hypothetical Bacillus subtilis protein (465 aa), FASTA scores: opt:1053, E(): 0, (34.8% identity in 821 aa overlap). The intein shows some similarity to inteins from U67548|MJU67548_6 Methanococcus jannaschii (895 aa), FASTA scores: opt: 181, E(): 0.00023, (25.2% identity in 274 aa overlap).	X2BI10,P67126,P67126	No	conserved hypotheticals			P67126					X2BI10,P67126					Rv1461		Rv1461			
NC_002945.3	Mycobrowser_v4	CDS	1646272	1647465	.	+	0	Mb1497	Mb1497		CONSERVED HYPOTHETICAL PROTEIN	Mb1497, -, len: 397 aa. Equivalent to Rv1462, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Conserved hypothetical protein. Equivalent to MLCL536.27c|Z99125 hypothetical protein from Mycobacterium leprae (392 aa), FASTA scores: opt: 2059, E(): 0, (80.4% identity in 392 aa overlap). Also similar to nearby Mycobacterium tuberculosis hypothetical protein Rv1461.	X2BIH2,P59973,P59973	No	conserved hypotheticals			P59973					X2BIH2,P59973					Rv1462		Rv1462			
NC_002945.3	Mycobrowser_v4	CDS	1647462	1648262	.	+	0	Mb1498	Mb1498		PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1498, -, len: 266 aa. Equivalent to Rv1463, len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 266 aa overlap). Probable conserved ATP-binding protein ABC transporter, equivalent to Z99125|MLCL536.26c putative ABC transporter ATP-binding protein from Mycobacterium leprae (260 aa), FASTA scores: opt: 1444, E(): 0, (86.0% identity in 267 aa overlap). Very similar to U38804|PPU38804_55 ATP-DEPENDENT TRANSPORTER YCF16 from PORPHYRA PURPUREA chloroplast (251 aa), FASTA scores: opt: 822, E(): 0, (52.4% identity in 248 aa overlap); and similar to others. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7U011,A0A1R3XYE2	No	cell wall and cell processes			A0A1R3XYE2				IPR003439,IPR003593,IPR010230,IPR027417	Q7U011					Rv1463		Rv1463			
NC_002945.3	Mycobrowser_v4	CDS	1649514	1650002	.	+	0	Mb1500	Mb1500		POSSIBLE NITROGEN FIXATION RELATED PROTEIN	Mb1500, -, len: 162 aa. Equivalent to Rv1465, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 162 aa overlap). Possible nitrogen fixation related protein. Equivalent to Z99125|MLCL536.24c nitrogen fixation protein NIFU from Mycobacterium leprae (165 aa), FASTA scores: opt: 870, E(): 0, (81.8% identity in 165 aa overlap). Also similar to O32163|Z99120|NIFU_BACSU NifU-like protein from Bacillus subtilis (147 aa), FASTA scores: opt: 354, E(): 4.1e-17,(38.3% identity in 141 aa overlap) and to AL096839|SCC22.02 hypothetical protein from Streptomyces coelicolor (156 aa), FASTA scores: opt: 569, E(): 1.2e-31,(56.3% identity in 158 aa overlap).	Q7U010,A0A1R3Y0J3	No	intermediary metabolism and respiration			A0A1R3Y0J3				IPR002871,IPR011341	Q7U010					Rv1465		Rv1465			
NC_002945.3	Mycobrowser_v4	CDS	1662950	1663510	.	+	0	Mb1512	Mb1512		POSSIBLE MEMBRANE PROTEIN	Mb1512, -, len: 186 aa. Equivalent to Rv1476, len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 186 aa overlap). Possible membrane protein, TMhelix 138-60.	Q7TZZ9,A0A1R3XYG3	No	cell wall and cell processes			A0A1R3XYG3					Q7TZZ9					Rv1476		Rv1476			
NC_002945.3	Mycobrowser_v4	CDS	1649977	1650324	.	+	0	Mb1501	Mb1501		conserved protein	Mb1501, -, len: 115 aa. Equivalent to Rv1466, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Conserved hypothetical protein. Equivalent to Z99125|MLCL536.23c hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 648, E(): 0, (81.7% identity in 115 aa overlap). Similar to ORF's downstream of sigma factors in Streptococcus mutans and Streptococcus pneumoniae e.g. O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa). Alternative TTG start possible at 13757 then avoids overlap with MTV007.12.	Q7U009,A0A1R3XZE4	No	conserved hypotheticals			A0A1R3XZE4				IPR002744	Q7U009					Rv1466		Rv1466			
NC_002945.3	Mycobrowser_v4	CDS	1675298	1675654	.	+	0	Mb1525	Mb1525		conserved protein	Mb1525, -, len: 118 aa. Equivalent to Rv1489, len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 118 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium avium subsp. paratuberculosis and Streptomyces coelicolor e.g. AJ250017_1 insertion sequence IS900, Locus 3, putative invasion protein from M. paratuberculosis (138 aa), FASTA scores: opt: 120, E(): 0.26, (34.375% identity in 96 aa overlap); SCD6.11c|AL353815_11 possible integral membrane protein from Streptomyces coelicolor (136 aa), FASTA scores: opt: 106, E(): 2.2, (35.9% identity in 103 aa overlap). ORF predicted by GC plot. Replaces previous Rv1489c on other strand.	Q7TZZ3,A0A1R3XYI2	No	conserved hypotheticals			A0A1R3XYI2					Q7TZZ3					Rv1489		Rv1489			
NC_002945.3	Mycobrowser_v4	CDS	2142705	2143175	.	-	0	Mb1941c	Mb1941c		conserved protein	Mb1941c, -, len: 156 aa. Equivalent to Rv1906c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, possibly exported protein,equivalent to Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa), FASTA scores: opt: 637, E(): 2.6e-28, (63.2% identity in 155 aa overlap). Also similar to M. tuberculosis hypothetical exported protein, Rv1352.	Q7TZB3,A0A1R3Y1T0	No	conserved hypotheticals			A0A1R3Y1T0					Q7TZB3					Rv1906c		Rv1906c			
NC_002945.3	Mycobrowser_v4	CDS	1718747	1719424	.	+	0	Mb1561	Mb1561		Probable transcriptional regulator	Mb1561, -, len: 225 aa. Equivalent to Rv1534, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 225 aa overlap). Probable transcriptional regulator, similar to YCDC_ECOLI|P75899 hypothetical transcriptional regulator from Escherichia coli (212 aa), FASTA scores: opt: 166, E(): 9.8e-05,(24.2% identity in 219 aa overlap). Contains PS01081 Bacterial regulatory proteins, tetR family signature and helix turn helix motif (aa 41-62).	Q7VEZ1,A0A1R3XZJ7	No	regulatory proteins			A0A1R3XZJ7				IPR001647,IPR009057,IPR011075,IPR015893,IPR023772	Q7VEZ1					Rv1534		Rv1534			
NC_002945.3	Mycobrowser_v4	CDS	1668123	1669130	.	+	0	Mb1517	Mb1517		PROBABLE MEMBRANE PROTEIN	Mb1517, -, len: 335 aa. Equivalent to Rv1481, len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 335 aa overlap). Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kd protein mav335 from M. avium (335 aa), FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317,E(): 2e-12, (26.5% identity in 340 aa overlap).	X2BII7,P64856,P64856	No	cell wall and cell processes			P64856					X2BII7,P64856					Rv1481		Rv1481			
NC_002945.3	Mycobrowser_v4	CDS	1657402	1659030	.	+	0	Mb1508	Mb1508		PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1508, -, len: 542 aa. Equivalent to Rv1473, len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 542 aa overlap). Possible macrolide-transport ATP-binding protein ABC transporter (see citation below), possibly in EF-3 subfamily. Similar to many ABC-transporters e.g. D90909_48|YHES_HAEIN from Synechocystis sp. strain PCC6803 (574 aa), FASTA scores: opt: 870, E(): 0, (33.3% identity in 525 aa overlap); P44808|YHES_HAEIN from Haemophilus influenzae (638 aa),FASTA scores: opt: 706, E(): 0, (33.7% identity in 517 aa overlap); etc. Contains two PS00017 ATP/GTP-binding site motif A (P-loop), and two PS00211 ABC transporter family signatures. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7U003,A0A1R3XYF2	No	cell wall and cell processes			A0A1R3XYF2				IPR003439,IPR003593,IPR017871,IPR027417	Q7U003					Rv1473		Rv1473			
NC_002945.3	Mycobrowser_v4	CDS	1659127	1659318	.	+	0	Mb1509	Mb1509		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1509, -, len: 63 aa. Equivalent to Rv1473A, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(98.4% identity in 63 aa overlap). Possible transcriptional regulator, CDS predicted by GC plot. Similar to SCI8.24c|AL132644_24 putative transcriptional regulator from Streptomyces coelicolor (73 aa), FASTA scores: opt: 210, E(): 1.5e-08, (56.15% identity in 57 aa overlap).	Q7U002,A0A1R3XYF8	No	regulatory proteins			A0A1R3XYF8					Q7U002					Rv1473A		Rv1473A			
NC_002945.3	Mycobrowser_v4	CDS	1659387	1659950	.	-	0	Mb1510c	Mb1510c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1510c, -, len: 187 aa. Equivalent to Rv1474c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 187 aa overlap). Probable transcription regulator, equivalent to AF0021|AF002133_1 transcriptional regulator from Mycobacterium avium strain GIR10 (82 aa),FASTA scores: opt: 490, E(): 6.7e-26, (92.5% identity in 80 aa overlap). Also similar to Q59431|UIDR_ECOLI UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli (196 aa), FASTA scores: opt: 192, E(): 5.8e-06, (28.5% identity in 172 aa overlap). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Helix turn helix motif predicted at aa 33-54 (+3.40 SD).	Q7U001,A0A1R3Y0K1	No	regulatory proteins			A0A1R3Y0K1				IPR001647,IPR009057,IPR011075,IPR015893	Q7U001					Rv1474c		Rv1474c			
NC_002945.3	Mycobrowser_v4	CDS	1719989	1720225	.	+	0	Mb1562	Mb1562		unknown protein	Mb1562, -, len: 78 aa. Equivalent to Rv1535, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 78 aa overlap). Hypothetical unknown protein.	Q7TZX4,A0A1R3XYL3	No	conserved hypotheticals			A0A1R3XYL3					Q7TZX4					Rv1535		Rv1535			
NC_002945.3	Mycobrowser_v4	CDS	1953643	1954308	.	+	0	Mb1771	Mb1771		unknown protein	Mb1771, -, len: 221 aa. Equivalent to the 3' end of Rv1742, len: 245 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 220 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TZN4,A0A1R3Y006	No				A0A1R3Y006					Q7TZN4										
NC_002945.3	Mycobrowser_v4	CDS	1665165	1665890	.	+	0	Mb1514	Mb1514		possible invasion protein	Mb1514, -, len: 241 aa. Equivalent to Rv1478, len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 241 aa overlap). Hypothetical Invasion protein. Possibly exported protein, nearly identical to AF0060|AF006054_2 hypothetical invasion protein INV2 of M. tuberculosis (240 aa), FASTA scores: opt: 1509, E(): 0,(95.0% identity in 241 aa overlap); very similar to AF0021|AF002133_5 hypothetical invasion protein INV2 from Mycobacterium avium (244 aa), FASTA scores: opt: 1269,E():0, (78.0% identity in 246 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY336.37 and weakly similar to C-terminal segment of p60 proteins of Listeria spp.e.g. Q01836|P60_LISIN PROTEIN P60 PRECURSOR (481 aa),FASTA scores: opt: 241, E():4e-07, (37.7% identity in 122 aa overlap). Highly similar to C-terminal domain of preceeding ORF Rv1477|MTV007.24 (472 aa), FASTA scores: opt: 864, E(): 0, (60.1% identity in 213 aa overlap).	Q7TZZ7,A0A1R3XYH7	No	virulence, detoxification, adaptation			A0A1R3XYH7				IPR000064	Q7TZZ7					Rv1478		Rv1478			
NC_002945.3	Mycobrowser_v4	CDS	1667159	1668112	.	+	0	Mb1516	Mb1516		conserved protein	Mb1516, -, len: 317 aa. Equivalent to Rv1480, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 317 aa overlap). Conserved hypothetical protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 KD Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642,E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693.	X2BI22,P64854	No	conserved hypotheticals			P64854					X2BI22					Rv1480		Rv1480			
NC_002945.3	Mycobrowser_v4	CDS	1669203	1670045	.	-	0	Mb1518c	Mb1518c		CONSERVED HYPOTHETICAL PROTEIN	Mb1518c, -, len: 280 aa. Equivalent to Rv1482c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to O07396|AF002133 Mycobacterium avium protein MAV346 (346 aa), FASTA scores: E(): 0,(65.2% identity in 342 aa overlap); slight similarity to GRPE_ECOLI|P09372 heat shock protein from E. coli (197 aa), FASTA scores: opt: 139, E(): 0.012, (28.3% identity in 159 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins Rv3517, Rv3555c, Rv3714c, Rv1073,etc. Start changed since first submission (-59 aa).	Q7TZZ5,A0A1R3XYG0	No	conserved hypotheticals			A0A1R3XYG0				IPR025159	Q7TZZ5					Rv1482c		Rv1482c			
NC_002945.3	Mycobrowser_v4	CDS	1672763	1673629	.	-	0	Mb1522c	Mb1522c		CONSERVED HYPOTHETICAL PROTEIN	Mb1522c, -, len: 288 aa. Equivalent to Rv1486c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 288 aa overlap). Conserved hypothetical protein, highly similar to YS07_MYCAV|O07402 hypothetical 33.5 kd protein mav321 from Mycobacterium avium (320 aa),FASTA scores: opt: 1217, E(): 0, (71.1% identity in 315 aa overlap). Weak similarity to AL079332|SCI5.07 hypothetical protein from Streptomyces coelicolor (259 aa), FASTA scores: opt: 131, E(): 0.29, (32.3% identity in 279 aa overlap). Start changed since original submission.	X2BIJ0,P59980	No	conserved hypotheticals			P59980					X2BIJ0					Rv1486c		Rv1486c			
NC_002945.3	Mycobrowser_v4	CDS	1673687	1674121	.	+	0	Mb1523	Mb1523		CONSERVED MEMBRANE PROTEIN	Mb1523, -, len: 144 aa. Equivalent to Rv1487, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved membrane protein. Highly similar to O07404|AF002133 MAV145 from Mycobacterium avium (145 aa), FASTA scores: opt: 667, E(): 0, (72.5% identity in 142 aa overlap). Also similar to AL079332|SCI5.05 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 344, E(): 1.3e-15,(44.8% identity in 134 aa overlap).	Q7TZZ4,A0A1R3XYW5	No	cell wall and cell processes			A0A1R3XYW5				IPR002810,IPR012340	Q7TZZ4					Rv1487		Rv1487			
NC_002945.3	Mycobrowser_v4	CDS	1674143	1675288	.	+	0	Mb1524	Mb1524		POSSIBLE EXPORTED CONSERVED PROTEIN	Mb1524, -, len: 381 aa. Equivalent to Rv1488, len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 381 aa overlap). Possible exported conserved protein; contains possible N-terminal signal sequence. Similar to YBBK_ECOLI|P77367 hypothetical protein ybbK from Escherichia coli (305 aa), FASTA scores: opt: 716, E(): 0, (37.1% identity in 307 aa overlap). Similar to stomatin-like proteins e.g. AF065260|AF065260_1 Clostridium difficile (320 aa), FASTA scores: opt: 767,E(): 0, (42.3% identity in 307 aa overlap).	X2BHS6,P63694,P63694	No	cell wall and cell processes			P63694					X2BHS6,P63694					Rv1488		Rv1488			
NC_002945.3	Mycobrowser_v4	CDS	1677954	1678712	.	-	0	Mb1528c	Mb1528c		CONSERVED MEMBRANE PROTEIN	Mb1528c, -, len: 252 aa. Equivalent to Rv1491c,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 252 aa overlap). Conserved membrane protein. Similar to hypothetical proteins from many organisms e.g. YDJZ_ECOLI|P76221 Escherichia coli (235 aa), FASTA scores: opt: 223, E():6.7e-07, (31.7% identity in 145 aa overlap); AL133252|SCE46.15 Streptomyces coelicolor (249 aa), FASTA scores: opt: 378, E(): 1.5e-17,(39.1% identity in 169 aa overlap). Also similar to M. tuberculosis hypothetical protein Rv0625c.	X2BI71,P67118,P67118	No	cell wall and cell processes			P67118					X2BI71,P67118					Rv1491c		Rv1491c			
NC_002945.3	Mycobrowser_v4	CDS	1683630	1684634	.	+	0	Mb1533	Mb1533		Possible transport system kinase	Mb1533, -, len: 334 aa. Equivalent to Rv1496, len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 334 aa overlap). Possible transport system kinase (EC 2.7.-.-). Equivalent to NP_302220.1|NC_002677 putative kinase from Mycobacterium leprae (327 aa). Highly similar to several transport system kinases and NTPase transporters e.g. P27254|ARGK_ECOLI|B2918 LAO/AO transport system kinase (EC 2.7.-.-) from Escherichia coli K12 (331 aa) (see citation below); NP_311815.1|NC_002695 ATPase component of two convergent arginine transporter from Escherichia coli O157:H7 (331 aa); etc. Also similar to YPLE_CAUCR|P37895 hypothetical 34.6 kd protein in Caulobacter crescentus (326 aa), FASTA scores, opt: 1125, E(): 0, (55.7% identity in 316 aa overlap).	X2BI73,P63578,P63578	No	cell wall and cell processes			P63578					X2BI73,P63578					Rv1496		Rv1496			
NC_002945.3	Mycobrowser_v4	CDS	1717623	1718750	.	+	0	Mb1560	Mb1560		conserved protein	Mb1560, -, len: 375 aa. Equivalent to Rv1533, len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 375 aa overlap). Conserved hypothetical protein. Similar to 2NPD_NEUCR|Q01284 2-nitropropane dioxygenase precursor (378 aa), fasta scores: opt: 279,E(): 9.1e-11, (31.3% identity in 256 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1894c, Rv0021c, Rv3553, Rv2781c.	Q7TZX5,A0A1R3Y0S2	No	conserved hypotheticals			A0A1R3Y0S2				IPR004136,IPR013785	Q7TZX5					Rv1533		Rv1533			
NC_002945.3	Mycobrowser_v4	CDS	1686049	1686822	.	-	0	Mb1535c	Mb1535c		PROBABLE METHYLTRANSFERASE	Mb1535c, -, len: 257 aa. Equivalent to possible methyltransferase TMAG_02827 from Mycobacterium tuberculosis strain SUMu001 (100% identity with 256 aa overlap). Similar to Rv1498c, len: 205 aa, from Mycobacterium tuberculosis strain H37Rv, (79% identity in 205 aa overlap). Probable methyltransferase (EC 2.1.1.-). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Contains PS00017 ATP/GTP-binding site motif A. Mb1535c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BIE0,A0A1R3XYJ0	No				A0A1R3XYJ0					X2BIE0										
NC_002945.3	Mycobrowser_v4	CDS	1687596	1688624	.	+	0	Mb1538	Mb1538		PROBABLE GLYCOSYLTRANSFERASE	Mb1538, -, len: 342 aa. Equivalent to Rv1500, len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 342 aa overlap). Probable glycosyltransferase (EC 2.-.-.- ), hydrophobic domain near C-terminus. Some similarity to putative glycosyl-transferases from Bacillus subtilis e.g. O34319|YKCC_BACSU (323 aa), opt: 490, E(): 6.1e-25,(28.85% identity in 312 aa overlap) and to N-acetyl glucosamine transferases. Also similar to G1001347 hypothetical 36.7 kDa protein (318 aa), FASTA scores: opt: 523, E(): 7.2e-26, (30.6% identity in 307 aa overlap).	Q7TZY7,A0A1R3XYH5	No	intermediary metabolism and respiration			A0A1R3XYH5				IPR001173	Q7TZY7					Rv1500		Rv1500			
NC_002945.3	Mycobrowser_v4	CDS	1688636	1689457	.	+	0	Mb1539	Mb1539		CONSERVED HYPOTHETICAL PROTEIN	Mb1539, -, len: 273 aa. Equivalent to Rv1501, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Conserved hypothetical protein, some similarity to O06374|Rv3633|MTCY15C10.19C hypothetical protein from Mycobacterium tuberculosis,FASTA scores: E(): 3.9e-10, (27.5% identity in 280 aa overlap).	X2BHT7,P67771	No	conserved hypotheticals			P67771					X2BHT7					Rv1501		Rv1501			
NC_002945.3	Mycobrowser_v4	CDS	1689670	1690020	.	+	0	Mb1540	Mb1540		HYPOTHETICAL PROTEIN [FIRST PART]	Mb1540, -, len: 116 aa. Equivalent to the 5' end of Rv1502, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, (94.7% identity in 114 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541.	Q7TZY6,A0A1R3Y0Q2	No				A0A1R3Y0Q2					Q7TZY6										
NC_002945.3	Mycobrowser_v4	CDS	1689999	1690568	.	+	0	Mb1541	Mb1541		HYPOTHETICAL PROTEIN [SECOND PART]	Mb1541, -, len: 189 aa. Equivalent to the 3' end of Rv1502, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 189 aa overlap). Hypothetical unknown protein.	Q7TZY5,A0A1R3XZI4	No				A0A1R3XZI4				IPR023296	Q7TZY5										
NC_002945.3	Mycobrowser_v4	CDS	1701666	1702709	.	+	0	Mb1550	Mb1550		Probable methyltransferase	Mb1550, -, len: 347 aa. Equivalent to Rv1523, len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 347 aa overlap). Probable methyltransferase (EC 2.1.1.-), similar to G560513|U0002O Mycobacterium leprae (270 aa), FASTA scores: opt: 965,E(): 0, (60.3% identity in 247 aa overlap). Also similar to many e.g. Q54303|X86780 METHYLTRANSFERASE RAPM from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 323, E(): 1e-15, (41.2% identity in 136 aa overlap). And similar to Mycobacterium tuberculosis hypothetical proteins Rv2952, Rv1405c, Rv1403c, Rv0839. Start uncertain.	Q7VEZ4,A0A1R3Y0R2	No	intermediary metabolism and respiration			A0A1R3Y0R2				IPR013216	Q7VEZ4					Rv1523		Rv1523			
NC_002945.3	Mycobrowser_v4	CDS	1690741	1691889	.	-	0	Mb1542c	Mb1542c		CONSERVED HYPOTHETICAL PROTEIN	Mb1542c, -, len: 382 aa. Equivalent to Rv1503c and Rv1504c, len: 182 aa and 199 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 182 aa overlap and 100% identity in 199 aa overlap). Conserved hypothetical protein, similar to C-terminal region of P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN from Escherichia coli (376 aa), FASTA scores: opt: 565,E(): 0, (49.4% identity in 170 aa overlap) and similar to N-terminal region of P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN from Escherichia coli (376 aa), FASTA scores: opt: 863, E(): 0, (68.0% identity in 194 aa overlap); Rv1503c and Rv1504c are both similar to RFFA_ECOLI but are separated by a stop codon, sequence appears to be correct so possible pseudogene. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1503c and Rv1504c exist as 2 genes. In Mycobacterium bovis, a single base transversion (t-g) leads to a single product.	Q7TVB9,A0A1R3XYJ3	No	conserved hypotheticals			A0A1R3XYJ3				IPR000653,IPR012749,IPR015421,IPR015422,IPR015424	Q7TVB9					Rv1503c		Rv1503c			
NC_002945.3	Mycobrowser_v4	CDS	1692026	1692691	.	-	0	Mb1543c	Mb1543c		CONSERVED HYPOTHETICAL PROTEIN	Mb1543c, -, len: 221 aa. Equivalent to Rv1505c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 221 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins and glycosylases e.g. P71063|O08181 HYPOTHETICAL 22.5 KD PROTEIN YVFD from Bacillus subtilis (216 aa), FASTA scores: E(): 2.4e-08, (25.5% identity in 196 aa overlap).	Q7TZY4,A0A1R3XYY4	No	conserved hypotheticals			A0A1R3XYY4				IPR001451,IPR011004,IPR020019	Q7TZY4					Rv1505c		Rv1505c			
NC_002945.3	Mycobrowser_v4	CDS	1692884	1693648	.	+	0	Mb1544	Mb1544		CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN	Mb1544, -, len: 254 aa. Equivalent to Rv1517, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 254 aa overlap). Conserved hypothetical transmembrane protein, similar to G466802|LEPB1170_F2_64 from Mycobacterium leprae (230 aa), FASTA scores: opt: 282, E(): 2.2e-11, (34.1% identity in 255 aa overlap). Also similar to Mycobacterium tuberculosis Rv3821|MTCY409.09c (237 aa) (36.3% identity in 256 aa overlap); and Rv3481c.	Q7TZY3,A0A1R3XYK5	No	cell wall and cell processes			A0A1R3XYK5				IPR021315	Q7TZY3					Rv1517		Rv1517			
NC_002945.3	Mycobrowser_v4	CDS	1693657	1694616	.	+	0	Mb1545	Mb1545		CONSERVED HYPOTHETICAL PROTEIN	Mb1545, -, len: 319 aa. Equivalent to Rv1518, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 319 aa overlap). Conserved hypothetical protein, possibly a glycosyl transferase involved in exopolysaccharide synthesis, similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from SYNECHO CYSTIS sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap).	Q7TZY2,A0A1R3XYK2	No	conserved hypotheticals			A0A1R3XYK2				IPR001173	Q7TZY2					Rv1518		Rv1518			
NC_002945.3	Mycobrowser_v4	CDS	1695041	1696081	.	+	0	Mb1547	Mb1547		probable sugar transferase	Mb1547, -, len: 346 aa. Equivalent to Rv1520, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 346 aa overlap). Probable sugar transferase (EC 2.-.-.-), similar to several e.g. AB010970|AB010970_6 Streptococcus mutans glycosyltransferase (465 aa), FASTA scores: opt: 381, E(): 1.2e-18, (31.7% identity in 240 aa overlap); O34234|Y07786 SUGAR TRANSFERASE from Vibrio cholerae (337 aa), FASTA scores: opt: 214, E(): 8.4e-05, (25.9% identity in 212 aa overlap). Also strongly similar to Mycobacterium tuberculosis probable sugar transferase Rv1516c.	X2BIL2,P64864	No	intermediary metabolism and respiration			P64864					X2BIL2					Rv1520		Rv1520			
NC_002945.3	Mycobrowser_v4	CDS	1702739	1703983	.	+	0	Mb1551	Mb1551		Probable glycosyltransferase	Mb1551, -, len: 414 aa. Equivalent to Rv1524, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 414 aa overlap). Probable glycosyltransferase (EC 2.4.1.-), similar to many e.g. P96559|U84349 GLYCOSYLTRANSFERASE GTFB from Amycolatopsis orientalis (407 aa), FASTA scores: opt: 363, E(): 6.2e-23,(28.8% identity in 430 aa overlap); also high similarity to Rv1526c|MTCY19G5.02 Mycobacterium tuberculosis hypothetical protein (58.7% identity in 416 aa overlap); and AF143772|AF143772_15 glycosyltransferase gtfB from Mycobacterium avium strain 215 (418 aa), FASTA scores: opt: 1801, E(): 0, (65.2% identity in 417 aa overlap).	X2BI44,P64866,P64866	No	intermediary metabolism and respiration			P64866					X2BI44,P64866					Rv1524		Rv1524			
NC_002945.3	Mycobrowser_v4	CDS	1704793	1706073	.	-	0	Mb1553c	Mb1553c		Probable glycosyltransferase	Mb1553c, -, len: 426 aa. Equivalent to Rv1526c,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 426 aa overlap). Probable glycosyltransferase (EC 2.4.1.-), highly similar to G467196 Protein L518_C2_147 from Mycobacterium leprae (421 aa), FASTA scores, opt: 1497, E(): 0, (55.0% identity in 424 aa overlap); similar to G452504 rhamnosyltransferase (24.7% identity in 433 aa overlap); and P96565|U84350 GLYCOSYLTRANSFERASE GTFE from Amycolatopsis orientalis (408 aa), E(): 3.4e-24, (28.4% identity in 429 aa overlap), also high similarity to Rv1524|MTCY19G5.04c (58.7 % identity in 416 aa overlap).	X2BI86,P64870,P64870	No	intermediary metabolism and respiration			P64870					X2BI86,P64870					Rv1526c		Rv1526c			
NC_002945.3	Mycobrowser_v4	CDS	1726858	1727784	.	+	0	Mb1567	Mb1567		CONSERVED HYPOTHETICAL PROTEIN MEMBER OF yabO/yceC/yfiI FAMILY	Mb1567, -, len: 308 aa. Equivalent to Rv1540, len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 308 aa overlap). Member of the yabO/yceC/yfiI family of hypothetical proteins, similar to P44445|YFII_HAEIN hypothetical protein HI0176 from Haemophilus influenzae (324 aa), FASTA scores: opt: 437,E(): 1.2e-22, (33.2% identity in 322 aa overlap). Equivalent to AL049478|MLCL458_13 hypothetical protein from Mycobacterium leprae (308 aa), (89.3% identity in 307 aa overlap). Contains PS01129 hypothetical yabO/yceC/yfiI family signature.	X2BIN2,P0A5T3,P0A5T3	No	conserved hypotheticals			P0A5T3					X2BIN2,P0A5T3					Rv1540		Rv1540			
NC_002945.3	Mycobrowser_v4	CDS	1729077	1730102	.	+	0	Mb1570	Mb1570		POSSIBLE FATTY ACYL-COA REDUCTASE	Mb1570, -, len: 341 aa. Equivalent to Rv1543, len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 341 aa overlap). Possible fatty-acyl CoA reductase (EC 1.2.1.-), highly similar to P94129|U77680 FATTY ACYL-COA REDUCTASE ACR1 from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 899, E(): 0,(48.5% identity in 293 aa overlap). Also highly similar to acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty acyl-CoA reductase from Mycobacterium tuberculosis (650 aa). Also highly similar to many oxidoreductases short-chain family.	X2BIH0,P66780,P66780	No	lipid metabolism			P66780					X2BIH0,P66780					Rv1543		Rv1543			
NC_002945.3	Mycobrowser_v4	CDS	1730107	1730910	.	+	0	Mb1571	Mb1571		Possible ketoacyl reductase	Mb1571, -, len: 267 aa. Equivalent to Rv1544, len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 267 aa overlap). Possible ketoacyl reductase (EC 1.3.1.-), highly similar to Z97179|MLCL383_26 putative oxidoreductase from Mycobacterium leprae (268 aa), FASTA score: (43.0% identity in 270 aa overlap). Also highly similar to others e.g. T29125 ketoacyl reductase homolog from Streptomyces coelicolor (276 aa); NP_470957.1|NC_003212 protein similar to ketoacyl reductases from Listeria innocua (253 aa); HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp. strain PCC 7120 (287 aa), FASTA scores: opt: 379, E(): 7.5e-18, (31.6% identity in 250 aa overlap); etc. And highly similar to many oxidoreductases short-chain family. Also highly similar to Rv2509 from Mycobacterium tuberculosis (268 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7VEY9,A0A1R3XZJ9	No	lipid metabolism			A0A1R3XZJ9				IPR002198,IPR002347,IPR016040,IPR020904	Q7VEY9					Rv1544		Rv1544			
NC_002945.3	Mycobrowser_v4	CDS	1731208	1731639	.	+	0	Mb1573	Mb1573		conserved protein	Mb1573, -, len: 143 aa. Equivalent to Rv1546, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 143 aa overlap). Conserved hypothetical protein, similar to O05902|Rv0910|MTCY21C12.04 Hypothetical protein from Mycobacterium tuberculosis (144 aa), FASTA scores: E(): 5e-30, (37.3% identity in 142 aa overlap).	X2BIA1,P64874	No	conserved hypotheticals			P64874					X2BIA1					Rv1546		Rv1546			
NC_002945.3	Mycobrowser_v4	CDS	1766009	1767430	.	-	0	Mb1602c	Mb1602c		Probable phiRV1 phage protein	Mb1602c, -, len: 473 aa. Equivalent to Rv1576c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 473 aa overlap). Probable phiRV1 phage protein (capsid subunit) (see citation below). Highly similar to hypothetical Mycobacterium tuberculosis protein Rv2650c|MTCY441.19 phiRV2 phage related protein, FASTA scores: opt: 2782, E(): 0, (89.1% identity in 468 aa overlap).	Q7VEY0,A0A1R3XZ36	No	insertion seqs and phages			A0A1R3XZ36				IPR006444,IPR024455	Q7VEY0					Rv1576c		Rv1576c			
NC_002945.3	Mycobrowser_v4	CDS	1745016	1745624	.	+	0	Mb1581	Mb1581		Possible regulatory protein	Mb1581, -, len: 202 aa. Equivalent to Rv1556, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 202 aa overlap). Possible regulatory protein, similar to X86780|SHGCPIR2|g987088 orfY,regulator of antibiotic transport complexes from Streptomyces hygroscopicus (204 aa), FASTA score: opt: 251, E(): 1.7e-10, (33.8% identity in 201 aa overlap) and others.	X2BI74,P67437,P67437	No	regulatory proteins			P67437					X2BI74,P67437					Rv1556		Rv1556			
NC_002945.3	Mycobrowser_v4	CDS	1749119	1749565	.	+	0	Mb1584	Mb1584		conserved protein	Mb1584, -, len: 148 aa. Equivalent to Rv1558, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 148 aa overlap). Conserved hypothetical protein, similar to other Mycobacterial tuberculosis proteins e.g. P71854|MTCY03C7.09c|Rv3547 (151 aa), FASTA scores opt: 330, E(): 9.1e-17, (39.7% identity in 151 aa overlap); also Q11057|Rv1261c (149 aa), and O53328|Rv3178 (119 aa). Similar also to AF072709|AF072709_5 Hypothetical protein with a new amplifiable element AUD4 from Streptomyces lividans (149 aa), FASTA scores: opt: 695,E(): 0, (69.1% identity in 149 aa overlap).	X2BHX8,P64876,P64876	No	conserved hypotheticals			P64876					X2BHX8,P64876					Rv1558		Rv1558			
NC_002945.3	Mycobrowser_v4	CDS	1765296	1765607	.	+	0	Mb1600	Mb1600		Probable phiRV1 phage related protein	Mb1600, -, len: 103 aa. Equivalent to Rv1574, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 103 aa overlap). Probable phiRV1 phage related protein (see citation below); some similarity to Rv1575|MTCY441.17, E() 1.5e-06; and Rv2647|MTCY336.29c phiRV2 phage protein, E(): 3.5e-05. Belongs to phage phiRv1 proteins. Helix turn helix motif present at aa 14-35 (+3.61 SD).	Q7VEY2,A0A1R3XZM7	No	insertion seqs and phages			A0A1R3XZM7					Q7VEY2					Rv1574		Rv1574			
NC_002945.3	Mycobrowser_v4	CDS	1757006	1759195	.	-	0	Mb1592c	Mb1592c		CONSERVED HYPOTHETICAL MEMBRANE PROTEIN	Mb1592c, -, len: 729 aa. Equivalent to Rv1565c,len: 729 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 729 aa overlap). Conserved hypothetical membrane protein, some similarity to O05402 HYPOTHETICAL 72.2 KD PROTEIN from Bacillus subtilis (634 aa), FASTA results: opt: 384, E(): 4.8e-17, (29.1% identity in 378 aa overlap); and to Y392_HAEIN|P43993 hypothetical protein hi0392 from H. influenzae (245 aa), FASTA results: opt: 265, E(): 5.5e-10, (28.3% identity in 247 aa overlap). C-terminal half equivalent to AL049478|MLCL458_19 (274 aa) (78.5% identity in 274 aa overlap). Also similar to M. tuberculosis hypothetical proteins Rv0111, Rv0228, Rv1254,Rv0517. N-terminal half hydrophobic.	Q7TZW8,A0A1R3XYP2	No	cell wall and cell processes			A0A1R3XYP2				IPR002656	Q7TZW8					Rv1565c		Rv1565c			
NC_002945.3	Mycobrowser_v4	CDS	1759294	1759986	.	-	0	Mb1593c	Mb1593c		Possible inv protein	Mb1593c, -, len: 230 aa. Equivalent to Rv1566c,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 230 aa overlap). Possible inv protein,probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa overlap); also to putative invasins 1,2 (O07390,O07391) from M. avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478, Rv0024, Rv2190c.	Q7VEY5,A0A1R3XZ27	No	virulence, detoxification, adaptation			A0A1R3XZ27				IPR000064	Q7VEY5					Rv1566c		Rv1566c			
NC_002945.3	Mycobrowser_v4	CDS	1763905	1764414	.	+	0	Mb1598	Mb1598		conserved protein	Mb1598, -, len: 169 aa. Equivalent to Rv1571, len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 169 aa overlap). Conserved hypothetical protein, similar at N-terminal region to Q49625|LEPB1170_C3_227 hypothetical protein from Mycobacterium leprae (104 aa), FASTA results: opt: 473,E(): 3.9e-24, (74.5% identity in 102 aa overlap). Identical to O06619|AF041819|AF041819_6 Mycobacterium bovis BCG (169 aa).	Q7TZW7,A0A1R3XYN9	No	conserved hypotheticals			A0A1R3XYN9				IPR009097	Q7TZW7					Rv1571		Rv1571			
NC_002945.3	Mycobrowser_v4	CDS	1764560	1764664	.	-	0	Mb1598A	Mb1598A		CONSERVED HYPOTHETICAL PROTEIN	Mb1598A, -, len: 34 aa. Equivalent to Rv1572c (MTCY336.31B), len: 34 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 34 aa overlap). Partial ORF, part of REP13E12 repeat element; 3' end of Rv1613c (Rv1587c) (MTCY336.17) after phage-like element (see citation below). Similar to C-terminal ends of other REP13E12 repeat elements e.g. Rv1148, Rv1945, Rv3467, etc. Length extended since first submission (+7 aa).	Q7TZW6,A0A1R3XYP9	No	insertion seqs and phages			A0A1R3XYP9					Q7TZW6					Rv1572c		Rv1572c			
NC_002945.3	Mycobrowser_v4	CDS	1765712	1766065	.	+	0	Mb1601	Mb1601		Probable phiRV1 phage protein	Mb1601, -, len: 117 aa. Similar to Rv1575 and Rv1575A, len: 117 aa and 65 aa, from Mycobacterium tuberculosis strain H37Rv, (66.9% identity in 124 aa overlap). Probable phiRV1 phage protein (see citation below). Similarity in N-terminal part to Rv1574|MTCY336.30c (103 aa), FASTA score: E(): 0.00022,(44.0% identity in 50 aa overlap); and Rv2647 phiRV2 phage protein. Similarity suggests should continue as Rv1575A. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1575 and Rv1575A exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base deletion (c-*) and a single base insertion (*-g) lead to a single product.	Q7VEY1,A0A1R3XYQ2	No				A0A1R3XYQ2					Q7VEY1										
NC_002945.3	Mycobrowser_v4	CDS	1771673	1771894	.	-	0	Mb1610c	Mb1610c		Possible phiRv1 phage protein	Mb1610c, -, len: 73 aa. Equivalent to Rv1584c, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 73 aa overlap). Possible phiRv1 phage protein (putative excisionase) (see citation below).	Q7VEX2,A0A1R3XZN2	No	insertion seqs and phages			A0A1R3XZN2					Q7VEX2					Rv1584c		Rv1584c			
NC_002945.3	Mycobrowser_v4	CDS	1767438	1767950	.	-	0	Mb1603c	Mb1603c		Probable phiRv1 phage protein	Mb1603c, -, len: 170 aa. Equivalent to Rv1577c,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 170 aa overlap). Probable phiRv1 phage protein (prohead protease) (see citation below). Highly similar to hypothetical protein Rv2651c|MTCY441.20c phiRV2 prohead protease, FASTA scores: E(): 0, (89.3% identity in 169 aa overlap). Some similarity to VP4_BPHK7|P49860 putative bacteriophage HK97 prohead protease (gp4) (225 aa), FASTA results: opt: 176, E(): 1.3e-05, (27.3% identity in 165 aa overlap).	Q7VEX9,A0A1R3XYR4	No	insertion seqs and phages			A0A1R3XYR4				IPR006433	Q7VEX9					Rv1577c		Rv1577c			
NC_002945.3	Mycobrowser_v4	CDS	1768124	1768594	.	-	0	Mb1604c	Mb1604c		Probable phiRv1 phage protein	Mb1604c, -, len: 156 aa. Equivalent to Rv1578c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 156 aa overlap). Probable phiRv1 phage protein (terminase) (see citation below), highly similar to Rv2652c|MTCY441.21c phiRV2 phage protein from M. tuberculosis, FASTA scores: E(): 4.8e-22, (48.1% identity in 156 aa overlap). Also similar to X65555|ARP3COS_1 hypothetical protein (cos site) - actinophage RP3 (210 aa), FASTA scores: opt: 373, E(): 6.5e-17, (50.0% identity in 114 aa overlap). Contains MIP family signature (PS00221).	Q7VEX8,A0A1R3XYR7	No	insertion seqs and phages			A0A1R3XYR7				IPR006448	Q7VEX8					Rv1578c		Rv1578c			
NC_002945.3	Mycobrowser_v4	CDS	1768986	1769258	.	-	0	Mb1606c	Mb1606c		Probable phiRv1 phage protein	Mb1606c, -, len: 90 aa. Equivalent to Rv1580c, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 90 aa overlap). Probable phiRv1 phage protein (see citation below).	Q7VEX6,A0A1R3XYR2	No	insertion seqs and phages			A0A1R3XYR2					Q7VEX6					Rv1580c		Rv1580c			
NC_002945.3	Mycobrowser_v4	CDS	1769863	1771278	.	-	0	Mb1608c	Mb1608c		Probable phiRv1 phage protein	Mb1608c, -, len: 471 aa. Equivalent to Rv1582c,len: 471 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 471 aa overlap). Probable phiRv1 phage protein (see citation below). N-terminus is similar to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519 aa),FASTA scores: opt: 331, E(): 6.5e-15, (28.5% identity in 235 aa overlap); and C-terminus to whole of Q38031 ORF10 of Bacteriophage phi-C31 (202 aa), FASTA scores: opt: 353,E(): 1e-16, (31.1% identity in 190 aa overlap). Also similar to part of AB016282|AB016282_42 Bacteriophage phi-105 (806 aa), FASTA scores: opt: 790, E(): 0, (32.7% identity in 459 aa overlap). Similarity to other phage proteins described as putative DNA-polymerase or DNA-primase. Also slightly similar to MTCY441.24c, FASTA scores: E(): 0.0055, (36.0% identity in 75 aa overlap).	Q7VEX4,A0A1R3XYQ8	No	insertion seqs and phages			A0A1R3XYQ8				IPR006500,IPR014015,IPR014818,IPR027417	Q7VEX4					Rv1582c		Rv1582c			
NC_002945.3	Mycobrowser_v4	CDS	1771278	1771676	.	-	0	Mb1609c	Mb1609c		Probable phiRv1 phage protein	Mb1609c, -, len: 132 aa. Equivalent to Rv1583c,len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 132 aa overlap). Probable phiRv1 phage protein (see citation below), highly similar to Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA score: E(): 1.3e-33, (81.7% identity in 131 aa overlap).	Q7VEX3,A0A1R3Y0W3	No	insertion seqs and phages			A0A1R3Y0W3				IPR024384	Q7VEX3					Rv1583c		Rv1583c			
NC_002945.3	Mycobrowser_v4	CDS	1772462	1773871	.	-	0	Mb1612c	Mb1612c		Probable phiRv1 integrase	Mb1612c, -, len: 469 aa. Equivalent to Rv1586c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 469 aa overlap). Probable phiRv1 integrase, possibly member of the serine family of recombinases (see citation below), similar to several bacteriophage integrases e.g. Q37839 ORF469 PROTEIN from Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E(): 1.6e-29, (31.1% identity in 482 aa overlap); and Bacteriophage TP901-1.	Q7VEX0,A0A1R3XZ46	No	insertion seqs and phages			A0A1R3XZ46				IPR006119,IPR011109,IPR025827	Q7VEX0					Rv1586c		Rv1586c			
NC_002945.3	Mycobrowser_v4	CDS	1773528	1774529	.	-	0	Mb1613c	Mb1613c		Partial REP13E12 repeat protein	Mb1613c, -, len: 333 aa. Equivalent to Rv1587c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(97.2% identity in 217 aa overlap). Partial REP13E12 repeat protein (see citation below), nearly identical (but has been interrupted by phiRv1 prophage) to Q50655|MTCY251.13c HYPOTHETICAL 34.6 KD PROTEIN from M. tuberculosis (317 aa), FASTA results: opt: 2020, E(): 0,(98.0% identity in 302 aa overlap); Rv0094c|MTCY251.13c (317 aa), FASTA results: E(): 0, (100.0% identity in 217 aa overlap). Codon usage suggests that translation may involve frameshifting of Rv1588c mRNA in poly_C stretch into reading frame of Rv1587c. 3' end found in Rv1572c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587 possibly exists as a pseudogene that has been disrupted when the phage entered.	Q7VEL3,A0A1R3XYS5	No	insertion seqs and phages			A0A1R3XYS5				IPR003615,IPR003870	Q7VEL3					Rv1587c		Rv1587c			
NC_002945.3	Mycobrowser_v4	CDS	1774534	1775202	.	-	0	Mb1614c	Mb1614c		Partial REP13E12 repeat protein	Mb1614c, -, len: 222 aa. Equivalent to Rv1588c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(98.2% identity in 222 aa overlap). Partial REP13E12 repeat protein (see citation below), nearly identical to ORF's in other Rep13E12 repeats, including Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypothetical 15.4 kd protein cy251.14 from Mycobacterium tuberculosis (136 aa),FASTA results: opt: 613, E(): 9.9e-29, (86.5% identity in 111 aa overlap).	X2BIL6,P0A5F2	No	insertion seqs and phages			P0A5F2					X2BIL6					Rv1588c		Rv1588c			
NC_002945.3	Mycobrowser_v4	CDS	1777766	1779106	.	-	0	Mb1618c	Mb1618c		CONSERVED HYPOTHETICAL PROTEIN	Mb1618c, -, len: 446 aa. Equivalent to Rv1592c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 446 aa overlap). Conserved hypothetical protein, some similarity to Q49629|B1170_F1_46 from Mycobacterium leprae (132 aa), FASTA results: opt: 332,E(): 4.5e-14, (56.3% identity in 87 aa overlap). Nearly identical to truncated Mycobacterium bovis BCG protein (148 aa) AF041819|AF041819_11.	Q7TZW5,A0A1R3XYR5	No	conserved hypotheticals			A0A1R3XYR5				IPR005152	Q7TZW5					Rv1592c		Rv1592c			
NC_002945.3	Mycobrowser_v4	CDS	1779363	1780073	.	-	0	Mb1619c	Mb1619c		conserved protein	Mb1619c, -, len: 236 aa. Equivalent to Rv1593c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). Conserved hypothetical protein, highly similar to Q49628|B1170_F1_44 from Mycobacterium leprae (286 aa), FASTA scores: opt: 1304, E (): 0, (85.4% identity in 233 aa overlap); similar to several putative DNA hydrolases e.g. Q9S233|SCI51.07C from Streptomyces coelicolor (239 aa), FASTA scores: opt: 415,E(): 4.6e-20, (34.8% identity in 221 aa overlap); also similar to P74291|SLR1690 hypothetical protein from synechocystis (261 aa), FASTA scores: opt: 228, E(): 1.4e-17, (31.5% identity in 213 aa overlap). TBparse score is 0.922	Q7TZW4,A0A1R3Y0X0	No	conserved hypotheticals			A0A1R3Y0X0				IPR000086,IPR011991,IPR015797	Q7TZW4					Rv1593c		Rv1593c			
NC_002945.3	Mycobrowser_v4	CDS	1821753	1822196	.	-	0	Mb1658c	Mb1658c		HYPOTHETICAL PROTEIN	Mb1658c, -, len: 147 aa. Equivalent to Rv1632c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 147 aa overlap). Hypothetical unknown protein.	Q7TZV1,A0A1R3XYW0	No	conserved hypotheticals			A0A1R3XYW0				IPR007295,IPR014465	Q7TZV1					Rv1632c		Rv1632c			
NC_002945.3	Mycobrowser_v4	CDS	1811364	1811951	.	-	0	Mb1650c	Mb1650c		Probable conserved membrane protein	Mb1650c, -, len: 195 aa. Equivalent to Rv1624c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 195 aa overlap). Probable membrane protein, first start taken. Some similarity to Rv3155 nuoK, NADH dehydrogenase chain K from Mycobacterium tuberculosis. Also similar to AAK72093.1|AF196488 hypothetical protein from Mycobacterium smegmatis (205 aa). Identities = 117/195 (60%).	Q7VEW1,A0A1R3XZR5	No	cell wall and cell processes			A0A1R3XZR5				IPR005325	Q7VEW1					Rv1624c		Rv1624c			
NC_002945.3	Mycobrowser_v4	CDS	1794809	1795516	.	+	0	Mb1636	Mb1636		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb1636, -, len: 235 aa. Equivalent to Rv1610, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 235 aa overlap). Possible conserved membrane protein. Equivalent to AL049913|MLCB1610_23 hypothetical protein from Mycobacterium leprae (264 aa),FASTA score: (65.8% identity in 231 aa overlap).	Q7TZW0,A0A1R3XYU4	No	cell wall and cell processes			A0A1R3XYU4				IPR011746,IPR019051	Q7TZW0					Rv1610		Rv1610			
NC_002945.3	Mycobrowser_v4	CDS	2525056	2525385	.	+	0	Mb2296	Mb2296		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2296, -, len: 109 aa. Equivalent to Rv2273, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Probable conserved transmembrane protein, similar to Rv2272 (MTCY339.38c),(35.0% identity in 100 aa overlap).	X2BKM3,P64972,P64972	No	cell wall and cell processes			P64972					X2BKM3,P64972					Rv2273		Rv2273			
NC_002945.3	Mycobrowser_v4	CDS	1825938	1827608	.	-	0	Mb1661c	Mb1661c		probable mannosyltransferase. probable conserved transmembrane protein.	Mb1661c, -, len: 556 aa. Equivalent to Rv1635c,len: 556 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 556 aa overlap). Membrane protein equivalent to CAC31770.1|AL583921 Mycobacterium leprae membrane protein (527 aa), Identities = 332/527 (62%).	Q7TZV0,A0A1R3XYV8	No	cell wall and cell processes			A0A1R3XYV8					Q7TZV0					Rv1635c		Rv1635c			
NC_002945.3	Mycobrowser_v4	CDS	1906884	1908065	.	+	0	Mb1723	Mb1723		CONSERVED HYPOTHETICAL PROTEIN	Mb1723, -, len: 393 aa. Equivalent to Rv1697, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Conserved hypothetical protein, highly similar to Q49895|MLC1351.11C|U00021 Hypothetical protein of Mycobacterium leprae from cosmid L247 (430 aa), FASTA scores: opt: 2345, E(): 0, (90.6% identity in 393 aa overlap).	Q7TZS0,A0A1R3XZ32	No	conserved hypotheticals			A0A1R3XZ32				IPR007371,IPR022215	Q7TZS0					Rv1697		Rv1697			
NC_002945.3	Mycobrowser_v4	CDS	1801049	1801447	.	+	0	Mb1642	Mb1642		CONSERVED MEMBRANE PROTEIN	Mb1642, -, len: 132 aa. Equivalent to Rv1616, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 132 aa overlap). Conserved membrane protein, with some similarity to other hypothetical proteins e.g. AL096884|SC4G6_9 from Streptomyces coelicolor cosmid 4G6 (148 aa), FASTA scores: opt: 245,E(): 1.7e-1 0, (36.7% identity in 128 aa overlap); Q55401|SLL0543 HYPOTHETICAL 16.5 KD PROTEIN from SYNECHOCYSTIS SP (148 aa), FASTA scores: opt: 225, E(): 6.5e-10, (35.9% identity in 117 aa overlap). Has cysteine cluster and contains a rubredoxin signature (PS00202).	Q7TZV9,A0A1R3XZ74	No	cell wall and cell processes			A0A1R3XZ74				IPR021215	Q7TZV9					Rv1616		Rv1616			
NC_002945.3	Mycobrowser_v4	CDS	1803941	1805395	.	+	0	Mb1645	Mb1645		CONSERVED MEMBRANE PROTEIN	Mb1645, -, len: 484 aa. Equivalent to Rv1619, len: 484 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 484 aa overlap). Conserved membrane protein. Some similarity to N-terminus of P94974|Rv1640c|MTCY06H11.04c PROBABLE LYSYL-TRNA SYNTHETASE 2 (EC 6.1.1.6) from Mycobacterium tuberculosis (1172 aa), FASTA scores: E(): 1.4e-16, (28.0% identity in 410 aa overlap); and similar in part to O69916| SC3C8.03C Putative intergral membrane protein from Streptomyces coelicolor cosmid 3C8 (589 aa), FASTA scores: opt: 453 E(): 8.4e-22, (31.3% identity in 313 aa overlap).	Q7TZV8,A0A1R3XYU9	No	cell wall and cell processes			A0A1R3XYU9				IPR024320	Q7TZV8					Rv1619		Rv1619			
NC_002945.3	Mycobrowser_v4	CDS	1881871	1882263	.	+	0	Mb1698	Mb1698		probable membrane protein	Mb1698, -, len: 130 aa. Equivalent to Rv1671, len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 130 aa overlap). Probable membrane protein. Weak similarity to mercuric transport proteins.	Q7TZT9,A0A1R3XYY1	No	cell wall and cell processes			A0A1R3XYY1					Q7TZT9					Rv1671		Rv1671			
NC_002945.3	Mycobrowser_v4	CDS	1832082	1832339	.	-	0	Mb1665c	Mb1665c		CONSERVED HYPOTHETICAL PROTEIN	Mb1665c, -, len: 85 aa. Equivalent to Rv1638A, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 85 aa overlap). Conserved hypothetical protein, similar to C-terminal part of P31511|35KD_MYCTU 35kd immunogenic protein from Mycobacterium tuberculosis (270 aa), FASTA scores: opt: 159, E(): 0.002, (50.90% identity in 55 aa overlap); and to Mycobacterium leprae ML0981 possible pseudogene, an orthologue of 35kd immunogenic protein from M. tuberculosis. Size difference suggests possible gene fragment.	Q7TVB8,A0A1R3XYX0	No	conserved hypotheticals			A0A1R3XYX0					Q7TVB8					Rv1638A		Rv1638A			
NC_002945.3	Mycobrowser_v4	CDS	3069820	3070011	.	+	0	Mb2829	Mb2829		POSSIBLE MEMBRANE PROTEIN	Mb2829, -, len: 63 aa. Equivalent to Rv2806, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Possible membrane protein, sharing no homology.	Q7TXT9	No	cell wall and cell processes								Q7TXT9	A0A1R3Y2P0				Rv2806		Rv2806			
NC_002945.3	Mycobrowser_v4	CDS	1813546	1814163	.	+	0	Mb1652	Mb1652		Probable two-component system transcriptional regulator	Mb1652, -, len: 205 aa. Equivalent to Rv1626, len: 205 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 205 aa overlap). Probable two-component response system transcriptional regulator, similar to many e.g. CHEY_BACSU|P24072 chemotaxis protein chey homolog (119 aa), FASTA scores: opt: 283, E(): 1.6e-16, (43.0% identity in 114 aa overlap). Also similar to AL109732|SC7H2_27 hypothetical protein from Streptomyces coelicolor (218 aa), opt: 880, E(): 0, (69.4% identity in 196 aa overlap).	Q7VEW0,A0A1R3XZ84	No	regulatory proteins			A0A1R3XZ84				IPR001789,IPR005561,IPR008327,IPR011006,IPR011991	Q7VEW0					Rv1626		Rv1626			
NC_002945.3	Mycobrowser_v4	CDS	1814231	1815439	.	-	0	Mb1653c	Mb1653c		Probable nonspecific lipid-transfer protein	Mb1653c, -, len: 402 aa. Equivalent to Rv1627c,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 402 aa overlap). Probable nonspecific lipid-transfer protein, similar to many lipid carrier proteins e.g. Q51797 ACETYL CoA SYNTHASE from Pyrococcus furiosus (388 aa), FASTA scores: opt: 400, E(): 3.2e-18,(34.4% identity in 407 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv3523,Rv3540c, Rv0244, Rv2790c, Rv1323, etc.	Q7VEV9,A0A1R3XYW1	No	lipid metabolism			A0A1R3XYW1				IPR002155,IPR013751,IPR016038,IPR016039	Q7VEV9					Rv1627c		Rv1627c			
NC_002945.3	Mycobrowser_v4	CDS	1951054	1951338	.	+	0	Mb1767	Mb1767		conserved protein	Mb1767, -, len: 94 aa. Equivalent to Rv1738, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 94 aa overlap). Conserved hypothetical protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kd protein from Mycobacterium tuberculosis (93 aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap).	X2BJ31,P64888	No	conserved hypotheticals			P64888					X2BJ31					Rv1738		Rv1738			
NC_002945.3	Mycobrowser_v4	CDS	1824534	1825949	.	+	0	Mb1660	Mb1660		Possible drug efflux membrane protein	Mb1660, -, len: 471 aa. Equivalent to Rv1634, len: 471 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 471 aa overlap). Possible drug efflux membrane protein of major facilitator superfamily (MFS),similar to many antibiotic resistance (efflux) proteins. FASTA best: Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE (GRAE) from Streptomyces violaceoruber (557 aa), opt: 415, E(): 1.7e-17, (26.7% identity in 446 aa overlap). Relatives in Mycobacterium tuberculosis: MTCY369.27c, E(): 4.8e-12; MTCY20B11.14c, E(): 2.9e-10.	Q7VEV8,A0A1R3XZR8	No	cell wall and cell processes			A0A1R3XZR8				IPR011701,IPR016196,IPR020846	Q7VEV8					Rv1634		Rv1634			
NC_002945.3	Mycobrowser_v4	CDS	2000453	2001013	.	-	0	Mb1805c	Mb1805c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1805c, -, len: 186 aa. Equivalent to Rv1776c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Possible regulatory protein, some similarity to Mycobacterium tuberculosis Rv1255c|Q11063 hypothetical transcriptional regulator (202 aa), FASTA scores: opt: 270, E( ): 9.7e-09, (28.3% identity in 191 aa overlap) . Contains possible helix-turn-helix motif at aa 37-58 (+3.49 SD).	Q7TZK2,A0A1R3XZB2	No	regulatory proteins			A0A1R3XZB2				IPR001647,IPR009057,IPR015893	Q7TZK2					Rv1776c		Rv1776c			
NC_002945.3	Mycobrowser_v4	CDS	1945252	1945884	.	-	0	Mb1762c	Mb1762c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb1762c, -, len: 210 aa. Equivalent to Rv1733c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 210 aa overlap). Probable conserved transmembrane protein. Similar to AL109962|SCJ1_26 hypothetical protein from Streptomyces coelicolor (193 aa), FASTA scores: opt: 287, E(): 3.8e-11, (35.2% identity in 182 aa overlap).	Q7TZP1,A0A1R3XZ65	No	cell wall and cell processes			A0A1R3XZ65					Q7TZP1					Rv1733c		Rv1733c			
NC_002945.3	Mycobrowser_v4	CDS	1828264	1829058	.	-	0	Mb1663c	Mb1663c		conserved protein	Mb1663c, -, len: 264 aa. Equivalent to Rv1637c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 264 aa overlap). Conserved hypothetical protein, some similarity to others e.g. P05446|GLO2_RHOBL PROBABLE HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) (255 aa), FASTA scores: opt: 252, E(): 2e-09, (39.0% identity in 146 aa overlap). Also similar to Q9Z505|AL035591|SCC54.20 putative hydrolase from Streptomyces coelicolor (218 aa), FASTA scores: opt: 732,E(): 0, (52.3% identity in 220 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins and putative glyoxylases e.g. Rv0634c, Rv3677c, Rv2581c,Rv2260.	Q7TZU8,A0A1R3XYW9	No	conserved hypotheticals			A0A1R3XYW9				IPR001279	Q7TZU8					Rv1637c		Rv1637c			
NC_002945.3	Mycobrowser_v4	CDS	1832355	1833824	.	-	0	Mb1666c	Mb1666c		CONSERVED HYPOTHETICAL MEMBRANE PROTEIN	Mb1666c, -, len: 489 aa. Equivalent to Rv1639c,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 489 aa overlap). Conserved hypothetical membrane protein. Some similarity to P35866|YLI2_CORGL Hypothetical 45.7 kd protein from Corynebacterium glutamicum (426 aa), FASTA scores: opt: 511, E( ): 2.4e-23, (28.9% identity in 370 aa overlap). Contains PS00904 protein phenyltransferases alpha subunit repeat signature.	Q7TZU7,A0A1R3XYX3	No	cell wall and cell processes			A0A1R3XYX3				IPR000801	Q7TZU7					Rv1639c		Rv1639c			
NC_002945.3	Mycobrowser_v4	CDS	1839764	1840819	.	-	0	Mb1672c	Mb1672c		CONSERVED HYPOTHETICAL PROTEIN	Mb1672c, -, len: 351 aa. Equivalent to Rv1645c,len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 351 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53837|Rv0826|MTV043.18 (351 aa), FASTA scores: (57.5% identity in 299 aa overlap); Q10519|Rv2237|YM37_MYCTU (255 aa), O53682|Rv0276 (306 aa).	Q7TZU6,A0A1R3XZA1	No	conserved hypotheticals			A0A1R3XZA1				IPR018713	Q7TZU6					Rv1645c		Rv1645c			
NC_002945.3	Mycobrowser_v4	CDS	1842139	1843089	.	+	0	Mb1674	Mb1674		adenylate cyclase (atp pyrophosphate-lyase) (adenylyl cyclase)	Mb1674, -, len: 316 aa. Equivalent to Rv1647, len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 316 aa overlap). Conserved hypothetical protein, some similarity to other Mycobacterium tuberculosis hypothetical proteins e.g. Q11055|Rv1264|YC64_MYCTU Hypothetical 42.2 kd protein (397 aa), FASTA scores: opt: 197, E(): 9.4e-06, (27.1% identity in 181 aa overlap) and Q10400|Rv2212|YM12_MYCTU (378 aa).	Q7TZU4,A0A1R3XYY5	No	intermediary metabolism and respiration			A0A1R3XYY5				IPR001054	Q7TZU4					Rv1647		Rv1647			
NC_002945.3	Mycobrowser_v4	CDS	1843096	1843902	.	+	0	Mb1675	Mb1675		Probable transmembrane protein	Mb1675, -, len: 268 aa. Equivalent to Rv1648, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 268 aa overlap). Probable transmembrane protein, some similarity to Rv3434c|MTCY77.06C (237 aa),FASTA scores: E(): 0.00039, (31.4% identity in 194 aa overlap).	Q7VEV5,A0A1R3XYY0	No	cell wall and cell processes			A0A1R3XYY0					Q7VEV5					Rv1648		Rv1648			
NC_002945.3	Mycobrowser_v4	CDS	1961998	1962729	.	+	0	Mb1777	Mb1777		unknown protein	Mb1777, -, len: 243 aa. Equivalent to Rv1748, len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 243 aa overlap). Hypothetical unknown protein. Possibly exported protein, hydrophobic domain, TM helix aa 23-45.	Q7TZM9,A0A1R3XZ76	No	conserved hypotheticals			A0A1R3XZ76					Q7TZM9					Rv1748		Rv1748			
NC_002945.3	Mycobrowser_v4	CDS	1891799	1892716	.	+	0	Mb1709	Mb1709		Probable coiled-coil structural protein	Mb1709, -, len: 305 aa. Equivalent to Rv1682, len: 305 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 305 aa overlap). Probable coiled-coil structural protein, weakly similar to many paramyosins,kinesins and plectins e.g. MYSP_ONCVO|Q02171 paramyosin from onchocerca volvulus (879 aa), fasta scores: opt: 180,E():2.6e-08, (24.4% identity in 234 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical coiled-coil proteins (wag31 antigen 84) Rv2145c and Rv2927c.	Q7VEU6,A0A1R3XZ06	No	conserved hypotheticals			A0A1R3XZ06				IPR007793	Q7VEU6					Rv1682		Rv1682			
NC_002945.3	Mycobrowser_v4	CDS	1946171	1946413	.	-	0	Mb1763c	Mb1763c		CONSERVED HYPOTHETICAL PROTEIN	Mb1763c, -, len: 80 aa. Equivalent to Rv1734c, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 80 aa overlap). Conserved hypothetical protein, similar to C-terminal region Q9Z8N2|CP0452|AE001615 Dihydrolipoamide Acetyltransferase from Chlamydia pneumoniae (429 aa), FASTA scores: opt: 138, E(): 0.0012, (26.9% identity in 78 aa overlap).	Q7TZP0,A0A1R3XZI3	No	conserved hypotheticals			A0A1R3XZI3				IPR001078,IPR023213	Q7TZP0					Rv1734c		Rv1734c			
NC_002945.3	Mycobrowser_v4	CDS	1962726	1963283	.	-	0	Mb1778c	Mb1778c		POSSIBLE INTEGRAL MEMBRANE PROTEIN	Mb1778c, -, len: 185 aa. Equivalent to Rv1749c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 185 aa overlap). Possible integral membrane protein, similar to O27914|AE000940 hypothetical protein MTH1892 from Methanobacterium thermoautotrophicum (168 aa), fasta scores: E(): 9.3e-16, (37.4% identity in 123 aa overlap).	Q7TZM8,A0A1R3XZ62	No	cell wall and cell processes			A0A1R3XZ62					Q7TZM8					Rv1749c		Rv1749c			
NC_002945.3	Mycobrowser_v4	CDS	1881516	1881863	.	+	0	Mb1697	Mb1697		CONSERVED HYPOTHETICAL PROTEIN	Mb1697, -, len: 115 aa. Equivalent to Rv1670, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Conserved hypothetical protein, highly similar to D90908|D90908_87 Hypothetical protein of Synechocystis sp. PCC6803 complete (94 aa),FASTA scores opt: 378, E(): 3.5e-2, (55.2% identity in 96 aa overlap); also shows some similarity to M.tuberculosis hypothetical proteins e.g. C-terminal region of O53404|Rv1056 (254 aa), and P96817|Rv0140 (126 aa).	Q7TZU0,A0A1R3XZ03	No	conserved hypotheticals			A0A1R3XZ03				IPR007361	Q7TZU0					Rv1670		Rv1670			
NC_002945.3	Mycobrowser_v4	CDS	2061500	2062378	.	+	0	Mb1856	Mb1856		conserved protein	Mb1856, -, len: 292 aa. Equivalent to Rv1825, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Conserved hypothetical protein, weak similarity to Mycobacterium tuberculosis hypothetical proteins Q50610|MTCY1A11.20C|Rv1823|Z78020 (307 aa), FASTA scores: opt: 182, E(): 0.00044, (29.9% identity in 204 aa overlap); and Rv0012. Has a hydrophobic stretch, TMhelix from aa 67 to 85	X2BJA8,P64896,P64896	No	conserved hypotheticals			P64896					X2BJA8,P64896					Rv1825		Rv1825			
NC_002945.3	Mycobrowser_v4	CDS	1889825	1890649	.	+	0	Mb1707	Mb1707		HYPOTHETICAL PROTEIN	Mb1707, -, len: 274 aa. Equivalent to Rv1680, len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 274 aa overlap). Hypothetical unknown protein.	Q7TZT0,A0A1R3XZ13	No	conserved hypotheticals			A0A1R3XZ13					Q7TZT0					Rv1680		Rv1680			
NC_002945.3	Mycobrowser_v4	CDS	1878963	1880738	.	-	0	Mb1695c	Mb1695c		probable second part of macrolide-transport atp-binding protein abc transporter	Mb1695c, -, len: 591 aa. Equivalent to Rv1668c and Rv1667c, len: 372 aa and 217 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 347 aa overlap and 100% identity in 217 aa overlap). Macrolide-transport ATP-binding protein ABC transporter (see citation below), similar to many ATP-binding proteins ABC transporter e.g. X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX gene (481 aa), FASTA scores: opt: 938, E(): 0, (45.6% identity in 353 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no error found, also same sequence in Mycobacterium tuberculosis CSU93 and Mycobacterium bovis. Contains PS00211 ABC transporters family signature and two times PS00017 ATP/GTP-binding site motif A. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis, a 10 bp insertion (*-tcttgccgcg) leads to a single product.	Q7TZU2,A0A1R3XZ10	No	cell wall and cell processes			A0A1R3XZ10				IPR003439,IPR003593,IPR006073,IPR017871,IPR027417	Q7TZU2					Rv1668c		Rv1668c			
NC_002945.3	Mycobrowser_v4	CDS	1882272	1883603	.	-	0	Mb1699c	Mb1699c		PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN	Mb1699c, -, len: 443 aa. Equivalent to Rv1672c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 443 aa overlap). Probable conserved integral membrane transport protein, major facilitator superfamily, similar to several phthalate transporters or tartrate transporters e.g. U25634|AVU25634_2 Agrobacterium vitis plasmid pTrAB (433 aa), FASTA scores: opt: 914, E(): 0, (37.1% identity in 426 aa overlap); etc.	Q7TZT8,A0A1R3XYZ8	No	cell wall and cell processes			A0A1R3XYZ8				IPR011701,IPR016196,IPR020846	Q7TZT8					Rv1672c		Rv1672c			
NC_002945.3	Mycobrowser_v4	CDS	1883696	1884628	.	-	0	Mb1700c	Mb1700c		CONSERVED HYPOTHETICAL PROTEIN	Mb1700c, -, len: 310 aa. Equivalent to Rv1673c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 310 aa overlap). Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap).	Q7TZT7,A0A1R3Y145	No	conserved hypotheticals			A0A1R3Y145				IPR002931	Q7TZT7					Rv1673c		Rv1673c			
NC_002945.3	Mycobrowser_v4	CDS	1884656	1885312	.	-	0	Mb1701c	Mb1701c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1701c, -, len: 218 aa. Equivalent to Rv1674c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 218 aa overlap). Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa),FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1.	Q7TZT6,A0A1R3XZU9	No	regulatory proteins			A0A1R3XZU9				IPR001307,IPR001763,IPR001845,IPR011991	Q7TZT6					Rv1674c		Rv1674c			
NC_002945.3	Mycobrowser_v4	CDS	1892934	1895933	.	+	0	Mb1710	Mb1710		possible bifunctional enzyme; long-chain acyl-coa synthase and lipase.	Mb1710, -, len: 999 aa. Equivalent to Rv1683, len: 999 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 999 aa overlap). Possible long-chain acyl-CoA synthase. Equivalent to Z95117|MLCB1351_21 possible long-chain acyl-CoA synthase from Mycobacterium leprae (1002 aa) (85.6% identity in 1002 aa overlap). Weakly similar to FATP_MOUSE|Q60714 long-chain fatty acid transport protein (646 aa), fasta scores: opt: 331, E(): 5e-08, (24.8% identity in 630 aa overlap). Also similar to O35488|AF033031 Mouse VERY-LONG-CHAIN ACYL-COA SYNTHETASE (620 aa), fasta scores: opt: 435, E(): 2.2e-12, (24.8% identity in 545 aa overlap). Weakly similar to M. tuberculosis protein MTCI364.18 (27.4% identity in 583 aa overlap) . Contains PS00120 Lipases, serine active site.	Q7VEU5,A0A1R3Y153	No	lipid metabolism			A0A1R3Y153				IPR000873	Q7VEU5					Rv1683		Rv1683			
NC_002945.3	Mycobrowser_v4	CDS	1896116	1896739	.	-	0	Mb1711c	Mb1711c		CONSERVED HYPOTHETICAL PROTEIN	Mb1711c, -, len: 207 aa. Equivalent to Rv1685c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 207 aa overlap). Conserved hypothetical protein, some similarity to other Mycobacterium tuberculosis hypothetical regulatory proteins e.g. Q10774|Rv1556|YF56_MYCTU (202 aa), FASTA scores: opt: 111,E(): 1.7e-05, (24.1% identity in 195 aa overlap); and P95215|Rv0258c|MTCY06A4.02c (151 aa) FASTA scores: (32.9% identity in 140 aa overlap); also similar to Q9X8G9|SCE7.13C|AL049819 putative Streptomyces coelicolor transcriptional regulator (204 aa), FASTA scores: opt: 480, E(): 6.4e-25, (40.4% identity in 203 aa overlap).	Q7TZS7,A0A1R3XZ14	No	conserved hypotheticals			A0A1R3XZ14				IPR001647,IPR009057,IPR011075,IPR015893	Q7TZS7					Rv1685c		Rv1685c			
NC_002945.3	Mycobrowser_v4	CDS	1896741	1897421	.	-	0	Mb1712c	Mb1712c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER	Mb1712c, -, len: 226 aa. Equivalent to Rv1686c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Probable conserved integral membrane protein ABC transporter (see citation below), similar to AL049819|SCE7.05 putative integral membrane protein from Streptomyces coelicolor (266 aa),FASTA sacores: opt: 661, E(): 0, (45.1% identity in 226 aa overlap); and Q53627|U43537 MEMBRANE PROTEIN INVOLVED IN MITHRAMYCIN RESISTANCE from STREPTOMYCES ARGILLACEUS (233 aa), FASTA scores: opt: 222, E(): 5.4e-10, (28.7% identity in 216 aa overlap).	Q7TZS6,A0A1R3XZE1	No	cell wall and cell processes			A0A1R3XZE1				IPR000412,IPR004377,IPR013525	Q7TZS6					Rv1686c		Rv1686c			
NC_002945.3	Mycobrowser_v4	CDS	1897493	1898260	.	-	0	Mb1713c	Mb1713c		PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1713c, -, len: 255 aa. Equivalent to Rv1687c,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 255 aa overlap). Probable conserved ATP-binding protein ABC transporter (see citation below),similar to many ABC-type transporters e.g. P55476|NODI_RHISN nodulation ATP-binding protein I from Rhizobium sp. (343 aa), FASTA scores: opt: 479, E(): 3.7e-23, (34.6% identity in 243 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC-type transporters e.g. MTCY19H9.04 (34.5% identity in 238 aa overlap). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Also contains PS00039 DEAD-box subfamily ATP-dependent helicases signature, though this may be spurious.	Q7TZS5,A0A1R3XZ19	No	cell wall and cell processes			A0A1R3XZ19				IPR003439,IPR003593,IPR017871,IPR027417	Q7TZS5					Rv1687c		Rv1687c			
NC_002945.3	Mycobrowser_v4	CDS	1901291	1902043	.	+	0	Mb1717	Mb1717		CONSERVED HYPOTHETICAL PROTEIN	Mb1717, -, len: 250 aa. Equivalent to Rv1691, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 250 aa overlap). Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa), FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap).	Q7TZS3,A0A1R3XYZ9	No	conserved hypotheticals			A0A1R3XYZ9				IPR011990	Q7TZS3					Rv1691		Rv1691			
NC_002945.3	Mycobrowser_v4	CDS	1902040	1903101	.	+	0	Mb1718	Mb1718		PROBABLE PHOSPHATASE	Mb1718, -, len: 353 aa. Equivalent to Rv1692, len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 353 aa overlap). Probable phosphatase (EC 3.1.-.-), some similarity to others e.g. PNPP_SCHPO|Q00472 4-nitrophenylphosphatase (269 aa), FASTA scores: opt: 214, E(): 1.3e-10, (29.5% identity in 241 aa overlap); and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa), FASTA scores: opt: 314, E(): 9.8e-08, (28.2% identity in 245 aa overlap). Also similar to AL109848|SCI51.28 hypothetical protein from Streptomyces coelicolor (343 aa), FASTA scores: opt: 768,E(): 0, (44.8% identity in 315 aa overlap).	Q7TZS2,A0A1R3XZ15	No	intermediary metabolism and respiration			A0A1R3XZ15				IPR006357,IPR023214,IPR023215	Q7TZS2					Rv1692		Rv1692			
NC_002945.3	Mycobrowser_v4	CDS	1903098	1903274	.	+	0	Mb1719	Mb1719		CONSERVED HYPOTHETICAL PROTEIN	Mb1719, -, len: 58 aa. Equivalent to Rv1693, len: 58 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 58 aa overlap). Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58.	Q7TZS1,A0A1R3Y163	No	conserved hypotheticals			A0A1R3Y163					Q7TZS1					Rv1693		Rv1693			
NC_002945.3	Mycobrowser_v4	CDS	2015286	2015489	.	+	0	Mb1814	Mb1814		probable ferredoxin	Mb1814, -, len: 67 aa. Equivalent to Rv1786, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable ferredoxin (EC 1.-.-.-), similar to others e.g. X63601|FERS_STRGR FERREDOXIN from Streptomyces griseus (65 aa), FASTA scores: opt: 140, E(): 0.001, (38.1% identity in 63 aa overlap); T50943 probable ferredoxin DitA from Pseudomonas abietaniphila (78 aa); BAA84714.1|AB017795 ferredoxin from Nocardioides sp. (69 aa); etc. Also similar to Rv0763c|MTCY369.08 from Mycobacterium tuberculosis (68 aa), FASTA score: (30.6% identity in 62 aa overlap); and Rv0763c.	Q7TZJ6,A0A1R3XZC4	No	intermediary metabolism and respiration			A0A1R3XZC4					Q7TZJ6					Rv1786		Rv1786			
NC_002945.3	Mycobrowser_v4	CDS	1910924	1911547	.	+	0	Mb1726	Mb1726		nudix hydrolase	Mb1726, -, len: 207 aa. Equivalent to Rv1700, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 207 aa overlap). Conserved hypothetical protein, equivalent to Q49891|MLC1351.08C|Z95117 Hypothetical protein from Mycobacterium leprae (177 aa),FASTA scores: (66.7% identity in 171 aa overlap); also similar to Q9S225|SCI51.15C|AL109848 Hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 508, E(): 1.2e-27, (43.1% identity in 197 aa overlap); similar to P54570|ADPP_BACSU ADP-RIBOSE PYROPHOSPHATASE (EC 3.6.1.13) (185 aa), FASTA scores: opt: 313, E(): 1.1e-06, (42.7% identity in 124 aa overlap).	Q7TZR9,A0A1R3XZ31	No	information pathways			A0A1R3XZ31				IPR000086,IPR015797	Q7TZR9					Rv1700		Rv1700			
NC_002945.3	Mycobrowser_v4	CDS	1911544	1912479	.	+	0	Mb1727	Mb1727		PROBABLE INTEGRASE/RECOMBINASE	Mb1727, -, len: 311 aa. Equivalent to Rv1701, len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 311 aa overlap). Probable integrase/recombinase, similar to many e.g. XERD_ECOLI|P21891 integrase/recombinase xerd (298 aa),FASTA scores: opt: 583, E(): 0, (41.8% identity in 311 aa overlap). Also similar to other Mycobacterium tuberculosis integrase/recombinase proteins RV2894c|MTCY274.25c (43.1% identity in 304 aa overlap); and Rv2646|MTCY441.16 phiRv2 integrase (31.1% identity in 161 aa overlap). Equivalent to Z95117|MLCB1351_7 from Mycobacterium leprae (316 aa) (85.4% identity in 316 aa overlap).	X2BIP5,P67637,P67637	No	insertion seqs and phages			P67637					X2BIP5,P67637					Rv1701		Rv1701			
NC_002945.3	Mycobrowser_v4	CDS	1912553	1913917	.	-	0	Mb1728c	Mb1728c		CONSERVED HYPOTHETICAL PROTEIN	Mb1728c, -, len: 454 aa. Equivalent to Rv1702c,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 454 aa overlap). Conserved hypothetical ORF in REP13E12 degenerate repeat. Similar to other hypothetical proteins inside REP13E12 elements (often in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317 aa), FASTA scores: opt: 1284, E(): 0, (59.7% identity in 315 aa overlap); and Rv1128c, Rv1945, Rv1148c, etc.	X2BI75,P64886	No	insertion seqs and phages			P64886					X2BI75					Rv1702c		Rv1702c			
NC_002945.3	Mycobrowser_v4	CDS	1914472	1915062	.	-	0	Mb1729c	Mb1729c		Probable catechol-o-methyltransferase	Mb1729c, -, len: 196 aa. Equivalent to Rv1703c,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 196 aa overlap). Probable catechol-o-methyltransferase (EC 2.1.1.6), most similar to COMT_HUMAN|P21964 soluble form of mammalian catechol o-methyltransferase (271 aa), FASTA scores: opt: 405, E(): 7 .8e-29, (38.9% identity in 190 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical methyltransferases Rv0187, Rv1220c.	Q7VEU3,A0A1R3Y172	No	intermediary metabolism and respiration			A0A1R3Y172				IPR002935,IPR025782	Q7VEU3					Rv1703c		Rv1703c			
NC_002945.3	Mycobrowser_v4	CDS	2209942	2210370	.	+	0	Mb2009	Mb2009		POSSIBLE CHITINASE	Mb2009, -, len: 142 aa. Equivalent to Rv1987, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Possible chitinase (EC 3.2.1.14), similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324,E(): 1.2e-14, (39.5% identity in 129 aa overlap).	X2BJT8,P64906,P64906	No	cell wall and cell processes			P64906					X2BJT8,P64906					Rv1987		Rv1987			
NC_002945.3	Mycobrowser_v4	CDS	1919823	1919990	.	-	0	Mb1733c	Mb1733c		CONSERVED HYPOTHETICAL PROTEIN	Mb1733c, -, len: 55 aa. Equivalent to Rv1706A, len: 55 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 55 aa overlap). Conserved hypothetical protein, similar to part of several probable export proteins e.g. Rv0783c|Z80226_28 from Mycobacterium tuberculosis (540 aa), FASTA scores: opt: 125, E(): 0.011,(52.85% identity in 53 aa overlap). Size difference suggests possible gene fragment.	Q7TZR5,A0A1R3XZ39	No	conserved hypotheticals			A0A1R3XZ39					Q7TZR5					Rv1706A		Rv1706A			
NC_002945.3	Mycobrowser_v4	CDS	1920223	1921683	.	+	0	Mb1734	Mb1734		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb1734, -, len: 486 aa. Equivalent to Rv1707, len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 486 aa overlap). Probable conserved transmembrane protein, possibly involved in transport of sulfate, similar to several hypothetical proteins belonging to the sulfate permease family e.g. P40877|YCHM_ECOLI hypothetical 58.4 kd protein in pth-prsa intergenic region from Escherichia coli (550 aa), FASTA scores: opt: 486, E(): 0, (33.1% identity in 492 aa overlap). Also similar to many other Mycobacterium tuberculosis membrane proteins eg. Rv3273, Rv1739c. SEEMS TO BELONG TO THE SULP FAMILY.	Q7TZR4,A0A1R3XZ51	No	cell wall and cell processes			A0A1R3XZ51				IPR002645,IPR011547	Q7TZR4					Rv1707		Rv1707			
NC_002945.3	Mycobrowser_v4	CDS	1921701	1922657	.	+	0	Mb1735	Mb1735		PUTATIVE INITIATION INHIBITOR PROTEIN	Mb1735, -, len: 318 aa. Equivalent to Rv1708, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 318 aa overlap). Putative initiation inhibitor protein, a soj-related protein probably involved in cell process, highly similar to many sporulation initiation inhibitor proteins soj e.g. P37522|SOJ_BACSU Soj protein from Bacillus subtilis (253 aa), FASTA scores: opt: 745, E(): 0, (46.0% identity in 248 aa overlap), and more weakly to various repA/para/incC proteins from various organisms e.g. Y4CK_RHISN|P55393 putative replication protein A from Rhizobium sp. (407 aa), FASTA scores: opt: 205, E(): 4e-13, (29.0% identity in 252 aa overlap). Also similar to Mycobacterium tuberculosis hyothetical proteins Rv3213c and Rv3918c.	Q7TZR3,A0A1R3XZ37	No	cell wall and cell processes			A0A1R3XZ37				IPR002586,IPR027417	Q7TZR3					Rv1708		Rv1708			
NC_002945.3	Mycobrowser_v4	CDS	1924179	1924943	.	+	0	Mb1738	Mb1738		CONSERVED HYPOTHETICAL PROTEIN	Mb1738, -, len: 254 aa. Equivalent to Rv1711, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 254 aa overlap). Conserved hypothetical protein, highly similar to a large family of hypothetical proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 aa), FASTA scores: opt: 496, E(): 1.1e-29, (41.6% identity in 250 aa overlap); 9S232|SCI51.08C|AL109848 PUTATIVE PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (371 aa), FASTA scores: opt: 818, E(): 0, (53.1% identity in 245 aa overlap). Equivalent to O05668|MLCB1351.03C|Z95117 Hypothetical protein from Mycobacterium leprae (256 aa),(80.5% identity in 256 aa overlap). Contains PS01149 Hypothetical yciL/yejD/yjbC family signature.	X2BI85,P65843,P65843	No	conserved hypotheticals			P65843					X2BI85,P65843					Rv1711		Rv1711			
NC_002945.3	Mycobrowser_v4	CDS	2217057	2217824	.	+	0	Mb2018	Mb2018		unknown protein	Mb2018, -, len: 255 aa. Equivalent to Rv1995, len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Hypothetical unknown protein.	X2BJU3,P64916	No	conserved hypotheticals			P64916					X2BJU3					Rv1995		Rv1995			
NC_002945.3	Mycobrowser_v4	CDS	3071960	3072271	.	+	0	Mb2832	Mb2832		HYPOTHETICAL PROTEIN	Mb2832, -, len: 103 aa. Equivalent to Rv2809, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 103 aa overlap). Hypothetical unknown protein. Questionable ORF.	Q7TXT6	No	conserved hypotheticals								Q7TXT6	A0A1R3Y2A6				Rv2809		Rv2809			
NC_002945.3	Mycobrowser_v4	CDS	1927194	1928006	.	+	0	Mb1741	Mb1741		Probable oxidoreductase	Mb1741, -, len: 270 aa. Equivalent to Rv1714, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 270 aa overlap). Probable oxidoreductase (EC 1.-.-.-) similar to many e.g. AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa), FASTA scores: opt: 578, E(): 3.3e-31, (38.9% identity in 265 aa overlap). Also similar to several other Mycobacterium tuberculosis oxidoreductases e.g. Rv1544, etc.	Q7VEU2,A0A1R3XZ44	No	intermediary metabolism and respiration			A0A1R3XZ44				IPR002198,IPR002347,IPR016040	Q7VEU2					Rv1714		Rv1714			
NC_002945.3	Mycobrowser_v4	CDS	1928917	1929747	.	+	0	Mb1744	Mb1744		CONSERVED HYPOTHETICAL PROTEIN	Mb1744, -, len: 276 aa. Equivalent to Rv1716, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 276 aa overlap). Conserved hypothetical protein, shows high similarity with AF1200|O29068|AE001021_11A conserved protein of Archaeoglobus fulgidus, gp fulgidus section 7 (278 aa),FASTA scores: E(): 0, (61.8% identity in 251 a a overlap); also weak similarity to several polyketide cyclases e.g. O68500|AF048833|DPSY from Streptomyces peucetius (272 aa),FASTA scores: opt: 194, E(): 1.7e-05, (29.6% identity in 223 aa overlap).	Q7TZQ8,A0A1R3XZ58	No	conserved hypotheticals			A0A1R3XZ58				IPR007325	Q7TZQ8					Rv1716		Rv1716			
NC_002945.3	Mycobrowser_v4	CDS	1929747	1930097	.	+	0	Mb1745	Mb1745		CONSERVED HYPOTHETICAL PROTEIN	Mb1745, -, len: 116 aa. Equivalent to Rv1717, len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 116 aa overlap). Conserved hypothetical protein, similar to O29060|AF1208|AE001021 Hypothetical protein from Arecheoglobus fulgidus (114 aa), FASTA scores: opt: 254, E(): 3.3e-09, (37.7% identity in 114 aa overlap).	Q7TZQ7,A0A1R3XZ53	No	conserved hypotheticals			A0A1R3XZ53				IPR011051,IPR013096,IPR014710	Q7TZQ7					Rv1717		Rv1717			
NC_002945.3	Mycobrowser_v4	CDS	1930150	1930773	.	+	0	Mb1746	Mb1746		CONSERVED HYPOTHETICAL PROTEIN	Mb1746, -, len: 207 aa. Equivalent to the 5' end of Rv1718, len: 272 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 193 aa overlap). Conserved hypothetical protein, similar to O29058|AF1210|AE001021 Hypothetical protein from Archeoglobus (313 aa), FASTA scores: opt: 301, E(): 8e-23, (31.6% identity in 301 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1718 exists as a single gene. In Mycobacterium bovis, a single base deletion (c-*) leads to a shorter product with a different COOH terminus.	Q7TZQ6,A0A1R3XZ47	No				A0A1R3XZ47				IPR008567,IPR013785	Q7TZQ6										
NC_002945.3	Mycobrowser_v4	CDS	1930981	1931760	.	+	0	Mb1748	Mb1748		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1748, -, len: 259 aa. Equivalent to Rv1719, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 259 aa overlap). Probable transcriptional regulatory protein, similar to YIAJ_ECOLI|P37671 hypothetical transcriptional regulator from Escherichia coli (282 aa), FASTA scores: opt: 353,E(): 3.2e-15, (31.1% identity in 235 aa overlap). Similar to Mycobacterium tuberculosis hypothetical IclR-family transcriptional regulators Rv2989, Rv1773c. Helix-turn-helix motif from aa 34-55 (+6.94 SD).	Q7TZQ5,A0A1R3XZ29	No	regulatory proteins			A0A1R3XZ29				IPR001808,IPR005471,IPR011991,IPR014757	Q7TZQ5					Rv1719		Rv1719			
NC_002945.3	Mycobrowser_v4	CDS	1933201	1934685	.	+	0	Mb1751	Mb1751		POSSIBLE CARBOXYLASE	Mb1751, -, len: 494 aa. Equivalent to Rv1722, len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 494 aa overlap). Possible carboxylases. Weak similarity to several e.g. ACCC_BACSU|P49787 biotin carboxylase from Bacillus subtilis (448 aa), fasta scores: opt: 171, E(): 0.00021, (22.8% identity in 237 aa overlap).	Q7TZQ2,A0A1R3XZY7	No	lipid metabolism			A0A1R3XZY7				IPR011761,IPR013816	Q7TZQ2					Rv1722		Rv1722			
NC_002945.3	Mycobrowser_v4	CDS	1934682	1935929	.	+	0	Mb1752	Mb1752		PROBABLE HYDROLASE	Mb1752, -, len: 415 aa. Equivalent to Rv1723, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). Possible hydrolase (EC 3.-.-.-), similar to others e.g. NYLB_FLASP|P07061 6-aminohexanoate-dimer hydrolase from Flavobacterium sp. (392 aa), FASTA scores: opt: 717, E(): 0, (35.1% identity in 396 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923, Rv1497, Rv2463, etc.	Q7TZQ1,A0A1R3XZ54	No	intermediary metabolism and respiration			A0A1R3XZ54				IPR001466,IPR012338	Q7TZQ1					Rv1723		Rv1723			
NC_002945.3	Mycobrowser_v4	CDS	2315209	2316180	.	-	0	Mb2102c	Mb2102c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2102c, -, len: 323 aa. Equivalent to Rv2077c,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Possible conserved transmembrane protein. Part of Mycobacterium tuberculosis protein family with Rv2542, Rv2079, Rv2797c, Rv0963c,Rv1949c. Hydrophobic stretches at C-terminus.	X2BJY5,P64934,P64934	No	cell wall and cell processes			P64934					X2BJY5,P64934					Rv2077c		Rv2077c			
NC_002945.3	Mycobrowser_v4	CDS	2061118	2061483	.	+	0	Mb1855	Mb1855		CONSERVED HYPOTHETICAL MEMBRANE PROTEIN	Mb1855, -, len: 121 aa. Equivalent to Rv1824, len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 121 aa overlap). Conserved hypothetical membrane protein similar to P28265|SBP_BACSU sbp protein from Bacillus subtilis (121 aa), FASTA scores: opt: 261, E(): 1.9e-12, (38.9% identity in 113 aa overlap).	X2BJ09,P64894,P64894	No	cell wall and cell processes			P64894					X2BJ09,P64894					Rv1824		Rv1824			
NC_002945.3	Mycobrowser_v4	CDS	1936381	1937091	.	-	0	Mb1754c	Mb1754c		CONSERVED HYPOTHETICAL PROTEIN	Mb1754c, -, len: 236 aa. Equivalent to Rv1725c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from BUTYRIVIBRIO FIBRISOLVENS, (108 aa), FASTA scores: opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158 aa).	Q7TZP9,A0A1R3XZ57	No	conserved hypotheticals			A0A1R3XZ57				IPR002577,IPR003033,IPR011991	Q7TZP9					Rv1725c		Rv1725c			
NC_002945.3	Mycobrowser_v4	CDS	1937192	1938577	.	+	0	Mb1755	Mb1755		PROBABLE OXIDOREDUCTASE	Mb1755, -, len: 461 aa. Equivalent to Rv1726, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 461 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt: 678, E(): 0, (29.5% identity in 465 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv3107c, Rv1257c, etc.	Q7TZP8,A0A1R3XZ69	No	intermediary metabolism and respiration			A0A1R3XZ69				IPR006094,IPR012951,IPR016166,IPR016167,IPR016169	Q7TZP8					Rv1726		Rv1726			
NC_002945.3	Mycobrowser_v4	CDS	1939204	1939974	.	-	0	Mb1757c	Mb1757c		CONSERVED HYPOTHETICAL PROTEIN	Mb1757c, -, len: 256 aa. Equivalent to Rv1728c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 256 aa overlap). Conserved hypothetical protein, some similarity to O07246|Rv0320|MTCY63.25 possible exported protein from Mycobacterium tuberculosis (220 aa), FASTA scores: E(): 1.3e-31, (42.3% identity in 220 aa overlap). C-terminal region similar to Q9ZX60|AF068845|AF068845_17 segment of gp17 of Mycobacteriophage TM4 (1229 aa), FASTA scores: opt: 385,E(): 4.3e-17, (44.6% identity in 139 aa overlap).	Q7TZP6,A0A1R3XZ56	No	conserved hypotheticals			A0A1R3XZ56					Q7TZP6					Rv1728c		Rv1728c			
NC_002945.3	Mycobrowser_v4	CDS	1939971	1940909	.	-	0	Mb1758c	Mb1758c		possible s-adenosylmethionine-dependent methyltransferase	Mb1758c, -, len: 312 aa. Equivalent to Rv1729c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 312 aa overlap). Conserved hypothetical protein, similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Q50726|Rv3399|YX99_MYCTU (348 aa), FASTA scores: opt: 1019, E(): 0, (55.7% identity in 296 aa overlap); P95074|Rv0726c (367 aa), O53795|Rv0731c (318 aa), and O53841|Rv0830 (301 aa), etc.	X2BIS2,Q7TZP5,Q7TZP5	No	lipid metabolism			Q7TZP5					X2BIS2,Q7TZP5					Rv1729c		Rv1729c			
NC_002945.3	Mycobrowser_v4	CDS	2100800	2101570	.	-	0	Mb1894c	Mb1894c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb1894c, -, len: 256 aa. Equivalent to Rv1863c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable conserved integral membrane protein, similar to Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from Mycobacterium tuberculosis (209 aa), FASTA scores: opt: 199, E(): 1e-06, (33.2% identity in 220 aa overlap); and Rv0658c.	Q7TZF2,A0A1R3XZJ3	No	cell wall and cell processes			A0A1R3XZJ3				IPR003675,IPR015837	Q7TZF2					Rv1863c		Rv1863c			
NC_002945.3	Mycobrowser_v4	CDS	1941089	1942642	.	-	0	Mb1759c	Mb1759c		POSSIBLE PENICILLIN-BINDING PROTEIN	Mb1759c, -, len: 517 aa. Equivalent to Rv1730c,len: 517 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 517 aa overlap). Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643, E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923, Rv1497, etc.	Q7TZP4,A0A1R3XZ52	No	cell wall and cell processes			A0A1R3XZ52				IPR001466,IPR012338	Q7TZP4					Rv1730c		Rv1730c			
NC_002945.3	Mycobrowser_v4	CDS	1951352	1953034	.	-	0	Mb1768c	Mb1768c		PROBABLE SULPHATE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER	Mb1768c, -, len: 560 aa. Equivalent to Rv1739c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 560 aa overlap). Probable sulphate-transport transmembrane protein ABC transporter,similar to several e.g. P53392|G607186 high affinity sulphate transporter from Stylosanthes hamata (662 aa),FASTA scores: opt: 382, E(): 1.6e-16, (28.0% identity in 564 aa overlap); U59234.1|AAB88215.1 biotin carb. from Synechococcus sp. PCC 7942 (574 aa), FASTA scores: opt: 1838, E(): 0, (50.0% identity in 550 aa overlap); etc. Contains PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), AND SEEMS TO BELONG TO THE SULP FAMILY.	Q7TZN7,A0A1R3XZ50	No	cell wall and cell processes	2KLN		A0A1R3XZ50				IPR001902,IPR002645,IPR011547	Q7TZN7					Rv1739c		Rv1739c			
NC_002945.3	Mycobrowser_v4	CDS	2191824	2192120	.	-	0	Mb1986c	Mb1986c		CONSERVED HYPOTHETICAL PROTEIN	Mb1986c, -, len: 98 aa. Equivalent to Rv1951c, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2541 (135 aa) (40.9% identity in 88 aa overlap).	Q7TZ81,A0A1R3XZX0	No	conserved hypotheticals			A0A1R3XZX0					Q7TZ81					Rv1951c		Rv1951c			
NC_002945.3	Mycobrowser_v4	CDS	1946688	1947185	.	-	0	Mb1764c	Mb1764c		HYPOTHETICAL MEMBRANE PROTEIN	Mb1764c, -, len: 165 aa. Equivalent to Rv1735c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Hypothetical membrane protein, similar to part of O58614|PH0884|AP000004 Hypothetical malic acid transport protein from Pyrococcus horikoshii (330 aa), FASTA scores: opt: 167, E(): 0.0003,(29.2% identity in 120 aa overlap).	Q7TZN9,A0A1R3XZ67	No	cell wall and cell processes			A0A1R3XZ67				IPR004695	Q7TZN9					Rv1735c		Rv1735c			
NC_002945.3	Mycobrowser_v4	CDS	1956387	1956788	.	-	0	Mb1773c	Mb1773c		PROBABLE MEMBRANE PROTEIN	Mb1773c, -, len: 133 aa. Equivalent to Rv1744c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 133 aa overlap). Probable membrane protein, contains four imperfect 10 aa repeats, some similarity to Q25946 (MSA-2) (FRAGMENT) from Plasmodium falciparum (205 aa), FASTA scores: opt: 145, E( ): 0.048,(52.4% identity in 63 aa overlap).	Q7TZN2,A0A1R3XZJ4	No	cell wall and cell processes			A0A1R3XZJ4				IPR016133	Q7TZN2					Rv1744c		Rv1744c			
NC_002945.3	Mycobrowser_v4	CDS	1959028	1961625	.	+	0	Mb1776	Mb1776		PROBABLE CONSERVED TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	Mb1776, -, len: 865 aa. Equivalent to Rv1747, len: 865 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 865 aa overlap). Probable conserved transmembrane ATP-binding protein ABC transporter (see citation below), similar to others e.g Q55956 ABC transporter from Synechocystis sp. (790 aa), FASTA scores: opt: 738, E(): 6.3e-26, (31.6% identity in 632 aa overlap); etc. Also similar to other Mycobacterium tuberculosis ABC-type transporters e.g. Rv2397c|MTCY253.24, FASTA score: (35.2% identity in 213 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TZN0,A0A1R3XZ83	No	cell wall and cell processes			A0A1R3XZ83				IPR000253,IPR003439,IPR003593,IPR008984,IPR013525,IPR017871,IPR027417	Q7TZN0					Rv1747		Rv1747			
NC_002945.3	Mycobrowser_v4	CDS	1970371	1972062	.	-	0	Mb1783c	Mb1783c		conserved protein	Mb1783c, -, len: 563 aa. Equivalent to Rv1754c,len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 563 aa overlap). Conserved hypothetical protein, has proline-rich central region. Some similarity in central region to other Mycobacterium tuberculosis proline-rich proteins e.g. O06555|Rv1157c|MTCI65.24c (371 aa), (32.5% identity in 191 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TZM3,A0A1R3XZK5	No	conserved hypotheticals			A0A1R3XZK5				IPR025442	Q7TZM3					Rv1754c		Rv1754c			
NC_002945.3	Mycobrowser_v4	CDS	1965019	1966401	.	+	0	Mb1780	Mb1780		PROBABLE OXIDOREDUCTASE	Mb1780, -, len: 460 aa. Equivalent to Rv1751, len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 460 aa overlap). Probable oxidoreductase (EC 1.-.-.-), possibly a monooxygenase or hydroxylase, similar to MHPA_ECOLI|P77397 3-(3-hydroxy-phenyl) propionate hydroxylase (554 aa),FASTA scores: opt: 239, E(): 2e-08, (24.6% identity in 435 aa overlap); and AJ007932|SAR7932.13 oxygenase from Streptomyces argillaceus (436 aa), FASTA scores: opt: 587,E(): 8.6e-30, (32.3% identity in 359 aa overlap). Contains PS00075 Dihydrofolate reductase signature. Also similar to Mycobacterium tuberculosis hypothetical oxidoreductases Rv1260 and Rv0575c.	Q7TZM6,A0A1R3Y1C5	No	intermediary metabolism and respiration			A0A1R3Y1C5				IPR002938,IPR003042	Q7TZM6					Rv1751		Rv1751			
NC_002945.3	Mycobrowser_v4	CDS	1966528	1966977	.	+	0	Mb1781	Mb1781		CONSERVED HYPOTHETICAL PROTEIN	Mb1781, -, len: 149 aa. Equivalent to Rv1752, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 149 aa overlap). Conserved hypothetical protein, similar to C-terminal half of Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase (EC 1.3.1.20) from Canis familiaris (335 aa), FASTA score,opt: 168, E(): 0.00015, (31.3% identity in 112 aa overlap).	Q7TZM5,A0A1R3Y027	No	conserved hypotheticals			A0A1R3Y027					Q7TZM5					Rv1752		Rv1752			
NC_002945.3	Mycobrowser_v4	CDS	1973919	1975103	.	-	0	Mb1785c	Mb1785c		CONSERVED HYPOTHETICAL PROTEIN	Mb1785c, -, len: 394 aa. Similar to MT1800 (also known as RVD2-ORF1), len: 381 aa, from Mycobacterium tuberculosis strain CDC1551, (99.71% identity in 345 aa overlap). Conserved hypothetical protein (see citation below), showing similarity with glycosyl transferases,sulfolipid sulfoquinovosyldiacylglycerol synthases, and hypothetical proteins, e.g. Q9R6U1|SQDX SQDX PROTEIN (required for biosynthesis of the sulfolipid sulfoquinovosyldiacylglycerol) from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (377 aa), FASTA scores: opt: 348, E(): 6.7e-15, (30.40% identity in 296 aa overlap); Q8YUR9|SQDX|ALR2265 SULFOLIPID SULFOQUINOVOSYLDIACYLGLYCEROL BIOSYNTHESIS PROTEIN from Anabaena sp. strain PCC 7120 (378 aa), FASTA scores: opt: 336, E(): 4e-14, (27.832% identity in 309 aa overlap); Q9AA50|CC0756 GLYCOSYL TRANSFERASE (GROUP 1 FAMILY PROTEIN) from Caulobacter crescentus (455 aa), FASTA scores: opt: 333, E(): 7.1e-14, (29.5% identity in 315 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region.	Q7TZM2,A0A1R3XZ97	No				A0A1R3XZ97				IPR001296	Q7TZM2										
NC_002945.3	Mycobrowser_v4	CDS	1975253	1976392	.	+	0	Mb1786	Mb1786		POSSIBLE SULFITE OXIDASE	Mb1786, -, len: 379 aa. Equivalent to MT1801, len: 379 aa, from Mycobacterium tuberculosis strain CDC1551,(99.75% identity in 379 aa overlap). See citations below. Possible sulfite oxidase (EC 1.8.3.1), showing similarity with others e.g. P51687|SUOX_HUMAN Sulfite oxidase,mitochondrial precursor from Homo sapiens (488 aa), FASTA scores: opt: 952, E(): 6.1e-52, (43.7% identity in 357 aa overlap); Q07116|SUOX_RAT Sulfite oxidase, mitochondrial precursor from Rattus norvegicus (488 aa), FASTA scores: opt: 952, E(): 6.1e-52, (43.8% identity in 356 aa overlap); Q9VWP4|CG7280 PROBABLE SULFITE OXIDASE PRECURSOR from Drosophila melanogaster (Fruit fly) (573 aa), FASTA scores: opt: 764, E(): 4e-40, (38.4% identity in 362 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 region.	Q7TZM1,A0A1R3XZ93	No				A0A1R3XZ93				IPR000572,IPR005066,IPR008335,IPR014756,IPR022407	Q7TZM1										
NC_002945.3	Mycobrowser_v4	CDS	1987699	1988955	.	-	0	Mb1794c	Mb1794c		CONSERVED HYPOTHETICAL PROTEIN	Mb1794c, -, len: 418 aa. Equivalent to Rv1765c,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(97.8% identity in 364 aa overlap). Conserved hypothetical protein, highly similar to O53461|Rv2015c|MTV018.02c CONSERVED HYPOTHETICAL PROTEIN (418 aa), (97.8% identity in 364 aa overlap). BLAST hits with non-IS part of sequence submitted under MTU78639. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 121 bp to 848 bp substitution affects the COOH part of Mb1794c leading to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 365 aa).	Q7TZL4,A0A1R3XZ95	No	conserved hypotheticals			A0A1R3XZ95				IPR002711,IPR003615,IPR003870	Q7TZL4					Rv1765c		Rv1765c			
NC_002945.3	Mycobrowser_v4	CDS	1985893	1986681	.	-	0	Mb1793c	Mb1793c		unknown protein	Mb1793c, -, len: 262 aa. Equivalent to Rv1762c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 262 aa overlap). Hypothetical unknown protein.	Q7TZL5,A0A1R3XZL4	No	conserved hypotheticals			A0A1R3XZL4				IPR002765	Q7TZL5					Rv1762c		Rv1762c			
NC_002945.3	Mycobrowser_v4	CDS	2195846	2196340	.	+	0	Mb1996	Mb1996		HYPOTHETICAL PROTEIN	Mb1996, -, len: 164 aa. Equivalent to Rv1961, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Hypothetical unknown protein.	Q7TZ72,A0A1R3XZW1	No	conserved hypotheticals			A0A1R3XZW1					Q7TZ72					Rv1961		Rv1961			
NC_002945.3	Mycobrowser_v4	CDS	2225748	2226500	.	+	0	Mb2024	Mb2024		CONSERVED HYPOTHETICAL PROTEIN	Mb2024, -, len: 250 aa. Equivalent to Rv2001, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0466,AL021933|MTV038_10 (264 aa), FASTA scores: opt: 592,E():0, (38.0% identity in 263 aa overlap).	Q7TZ62,A0A1R3XZW3	No	conserved hypotheticals			A0A1R3XZW3				IPR002864	Q7TZ62					Rv2001		Rv2001			
NC_002945.3	Mycobrowser_v4	CDS	1983993	1985522	.	+	0	Mb1791	Mb1791		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb1791, -, len: 509 aa. Equivalent to the 5' end of Rv1760, len: 502 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 442 aa overlap). Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. Q10554|Y895_MYCTU|MTCY31.23 (505 aa), FASTA scores: opt: 692, E(): 0, (31.7% identity in 477 aa overlap). Member of family with at least 15 other members e.g. Rv3740c,Rv3734c, Rv1425, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TZL7,A0A1R3Y029	No				A0A1R3Y029				IPR004255,IPR014292	Q7TZL7										
NC_002945.3	Mycobrowser_v4	CDS	1985510	1985893	.	-	0	Mb1792c	Mb1792c		possible exported protein	Mb1792c, -, len: 127 aa. Equivalent to Rv1761c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 127 aa overlap). Possibly exported protein with hydrophobic stretch or TMhelix at aa 15-37.	Q7TZL6,A0A1R3XZA7	No	cell wall and cell processes			A0A1R3XZA7					Q7TZL6					Rv1761c		Rv1761c			
NC_002945.3	Mycobrowser_v4	CDS	1990177	1990446	.	+	0	Mb1795A	Mb1795A		conserved protein	Mb1795A, -, len: 89 aa. Equivalent to Rv1766, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Conserved hypothetical protein, highly similar to P54431|YRKD_BACSU Hypothetical 7.0 kDa protein in bltr-spoIIIC intergenic region from Bacillus subtilis (63 aa), FASTA scores: opt: 151, E(): 1.5e-05, (53.3% identity in 45 aa overlap). Also similar to Q9RD62|SCF56.04C|AL133424 Hypothetical protein from Streptomyces coelicolor (92 aa), FASTA scores: opt: 239,E(): 1.3e-11, (62.5% identity in 64 aa overlap). Also some similarity to other Mycobacterium tuberculosis hypothetical proteins e.g. O07434|Rv0190|MTCI28.29 (96 aa), (35.5% identity in 62 aa overlap); P71543|Rv0967 (119 aa), and P71600|Rv0030 (109 aa). Start changed since original submission.	Q7TZL2,A0A1R3XZA6	No	conserved hypotheticals			A0A1R3XZA6				IPR003735	Q7TZL2					Rv1766		Rv1766			
NC_002945.3	Mycobrowser_v4	CDS	2192911	2193213	.	+	0	Mb1988A	Mb1988A		Hypothetical protein	Mb1988A, len: 100 aa. Equivalent to Rv1954A len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 100 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Hypothetical unknown protein.	X2BJQ1,A0A1R3XZT2	No	unknown			A0A1R3XZT2					X2BJQ1					Rv1954A		Rv1954A			
NC_002945.3	Mycobrowser_v4	CDS	1993084	1994328	.	+	0	Mb1798	Mb1798		conserved protein	Mb1798, -, len: 414 aa. Equivalent to Rv1769, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Conserved hypothetical protein, similar to O88066|SCI35.31|AL031541 hypothetical protein from Streptomyces coelicolor (402 aa), FASTA scores: opt: 1341, E(): 0, (53.8% identity in 398 aa overlap).	Q7TZK9,A0A1R3XZ90	No	conserved hypotheticals			A0A1R3XZ90				IPR001608	Q7TZK9					Rv1769		Rv1769			
NC_002945.3	Mycobrowser_v4	CDS	1994336	1995622	.	+	0	Mb1799	Mb1799		conserved protein	Mb1799, -, len: 428 aa. Equivalent to Rv1770, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). Conserved hypothetical protein, highly similar in N-terminus to Q49882 Hypothetical protein from Mycobacterium leprae from cosmid L247 (83 aa), FASTA scores: opt: 301, E(): 1e-12,(56.5% identity in 85 aa overlap).	Q7TZK8,A0A1R3Y1E3	No	conserved hypotheticals			A0A1R3Y1E3				IPR007484	Q7TZK8					Rv1770		Rv1770			
NC_002945.3	Mycobrowser_v4	CDS	1995619	1996905	.	+	0	Mb1800	Mb1800		l-gulono-1,4-lactone dehydrogenase	Mb1800, -, len: 428 aa. Equivalent to Rv1771, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to e.g. GGLO_RAT|P10867 l-gulonolactone oxidase (ec 1.1.3.8) (439 aa), FASTA scores: opt: 862, E(): 0, (34.1% identity in 434 aa overlap). Also shows slight similarity to Mycobacterium tuberculosis oxidoreductase Rv1726|MTCY04C12.11 (22.9% identity in 441 aa overlap) and others e.g. Rv3107c, Rv1257c, Rv2251, etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.	Q7TZK7,A0A1R3Y038	No	intermediary metabolism and respiration			A0A1R3Y038				IPR006093,IPR006094,IPR007173,IPR010032,IPR016166,IPR016167,IPR016169,IPR023595	Q7TZK7					Rv1771		Rv1771			
NC_002945.3	Mycobrowser_v4	CDS	1997094	1997405	.	+	0	Mb1801	Mb1801		HYPOTHETICAL PROTEIN	Mb1801, -, len: 103 aa. Equivalent to Rv1772, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Hypothetical unknown protein.	Q7TZK6,A0A1R3XZB7	No	conserved hypotheticals			A0A1R3XZB7				IPR005561,IPR011991,IPR024189	Q7TZK6					Rv1772		Rv1772			
NC_002945.3	Mycobrowser_v4	CDS	1997478	1998224	.	-	0	Mb1802c	Mb1802c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1802c, -, len: 248 aa. Equivalent to Rv1773c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Probable transcriptional regulator belonging to IclR family,similar to ICLR_ECOLI|P16528 acetate operon repressor from Escherichia coli (274 aa), FASTA scores: opt: 261, E(): 3.3e-10, (26.9% identity in 249 aa overlap). Also similar to Mycobacterium tuberculosis protein Rv1719|MTCY04C12.04 (40.2% identity in 244 aa overlap); and Rv2989. Start site chosen by homology, but may extend further upstream. Contains possible helix-turn-helix motif at aa 37-58 (+3.24 SD).	Q7TZK5,A0A1R3XZM4	No	regulatory proteins			A0A1R3XZM4				IPR005471,IPR011991,IPR014757	Q7TZK5					Rv1773c		Rv1773c			
NC_002945.3	Mycobrowser_v4	CDS	1998290	1999630	.	+	0	Mb1803	Mb1803		PROBABLE OXIDOREDUCTASE	Mb1803, -, len: 446 aa. Equivalent to Rv1774, len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 446 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to several e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa),FASTA scores: opt: 417, E(): 6e-20, (28.4% identity in 462 aa overlap). Also some similarity to Mycobacterium tuberculosis oxidoreductase MTCY04C12.11 (24.1% identity in 444 aa overlap). Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.	Q7TZK4,A0A1R3XZA5	No	intermediary metabolism and respiration			A0A1R3XZA5				IPR006093,IPR006094,IPR016166,IPR016167,IPR016169	Q7TZK4					Rv1774		Rv1774			
NC_002945.3	Mycobrowser_v4	CDS	1999630	2000448	.	+	0	Mb1804	Mb1804		CONSERVED HYPOTHETICAL PROTEIN	Mb1804, -, len: 272 aa. Equivalent to Rv1775, len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, similar to O28806|AF1466 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (255 aa),FASTA scores: opt: 364, E(): 1e-17, (29.2% identity in 267 aa overlap).	Q7TZK3,A0A1R3XZB6	No	conserved hypotheticals			A0A1R3XZB6					Q7TZK3					Rv1775		Rv1775			
NC_002945.3	Mycobrowser_v4	CDS	2002539	2002988	.	-	0	Mb1807c	Mb1807c		unknown protein	Mb1807c, -, len: 149 aa. Equivalent to Rv1778c,len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 149 aa overlap). Hypothetical unknown protein.	Q7TZK1,A0A1R3XZ85	No	conserved hypotheticals			A0A1R3XZ85					Q7TZK1					Rv1778c		Rv1778c			
NC_002945.3	Mycobrowser_v4	CDS	2146986	2147579	.	-	0	Mb1945c	Mb1945c		PROBABLE EXPORTED PROTEIN	Mb1945c, -, len: 197 aa. Equivalent to Rv1910c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 197 aa overlap). Possible exported protein, very similar to upstream ORF MTCY180.07 (201 aa),FASTA score: E(): 0, (64.0% identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN PROTEIN CPN0877 from Chlamydophila pneumoniae (150 aa).	X2BJG2,P67223	No	cell wall and cell processes			P67223					X2BJG2					Rv1910c		Rv1910c			
NC_002945.3	Mycobrowser_v4	CDS	2021521	2022423	.	+	0	Mb1822	Mb1822		conserved protein	Mb1822, -, len: 300 aa. Equivalent to Rv1794, len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Conserved hypothetical protein, slight similarity to Mycobacterium tuberculosis O53694|Rv0289|MTV035.17, (295 aa), FASTA scores: opt: 172, E(): 0.00083, (25.7% identity in 261 aa overlap). Equivalent to Mycobacterium leprae hypothetical protein Q9Z5I1|MLCB596.31|AL035472 (300 aa), (88.0% identity in 300 aa overlap). Contains PS00211 ABC transporters family signature.	Q7TZJ0,A0A1R3XZP3	No	conserved hypotheticals			A0A1R3XZP3				IPR025734	Q7TZJ0					Rv1794		Rv1794			
NC_002945.3	Mycobrowser_v4	CDS	2037478	2037804	.	-	0	Mb1833c	Mb1833c		conserved protein	Mb1833c, -, len: 108 aa. Equivalent to Rv1804c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Conserved hypothetical protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (hydrophobic stretch at N-terminus) e.g. O07222|Rv1810|MTCY16F9.04C|Z96073 (118 aa), FASTA scores: opt: 361, E(): 2.3e-19, (53.5% identity in 101 aa overlap); Rv0622, Rv1690, and Rv3067, etc.	Q7TZI1,A0A1R3XZD2	No	conserved hypotheticals			A0A1R3XZD2				IPR007969	Q7TZI1					Rv1804c		Rv1804c			
NC_002945.3	Mycobrowser_v4	CDS	2038142	2038489	.	-	0	Mb1834c	Mb1834c		HYPOTHETICAL PROTEIN	Mb1834c, -, len: 115 aa. Equivalent to Rv1805c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Hypothetical unknown protein.	Q7TZI0,A0A1R3XZF2	No	conserved hypotheticals			A0A1R3XZF2					Q7TZI0					Rv1805c		Rv1805c			
NC_002945.3	Mycobrowser_v4	CDS	2065923	2066180	.	+	0	Mb1862	Mb1862		HYPOTHETICAL PROTEIN	Mb1862, -, len: 85 aa. Equivalent to Rv1831, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Hypothetical unknown protein.	X2BJ45,P64900	No	conserved hypotheticals			P64900					X2BJ45					Rv1831		Rv1831			
NC_002945.3	Mycobrowser_v4	CDS	2244905	2245321	.	+	0	Mb2042	Mb2042		conserved protein	Mb2042, -, len: 138 aa. Equivalent to Rv2019, len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Hypothetical protein.	Q7TZ54,A0A1R3Y032	No	conserved hypotheticals			A0A1R3Y032					Q7TZ54					Rv2019		Rv2019			
NC_002945.3	Mycobrowser_v4	CDS	2044612	2045814	.	-	0	Mb1842c	Mb1842c		PROBABLE DEHYDROGENASE	Mb1842c, -, len: 400 aa. Equivalent to Rv1812c,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 400 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to other dehydrogenases/oxidases e.g. AE001947|AE001947_10 NADH dehydrogenase II of Deinococcus radiodurans (379 aa), FASTA scores: opt: 404,E(): 3.4e-18, (26.4% identity in 363 aa overlap) and DHNA_HAEIN|P44856 nadh dehydrogenase (EC 1.6.99.3) (444 aa), FASTA scores: opt: 200, E(): 8.5e-06, (23.3% identity in 258 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases Rv0392c, and Rv1854c|MTCY359.19 ndh probable NADH dehydrogenase (31.5% identity in 321 aa overlap).	Q7TZH3,A0A1R3XZF5	No	intermediary metabolism and respiration			A0A1R3XZF5				IPR000103,IPR001327,IPR013027,IPR016040,IPR023753	Q7TZH3					Rv1812c		Rv1812c			
NC_002945.3	Mycobrowser_v4	CDS	2046136	2046567	.	-	0	Mb1843c	Mb1843c		CONSERVED HYPOTHETICAL PROTEIN	Mb1843c, -, len: 143 aa. Equivalent to Rv1813c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein. Possibly a exported protein with potential N-terminal signal sequence. Similar to Q11050|Rv1269c|MTCY50.13 hypothetical protein from Mycobacterium tuberculosis (124 aa), (42.7% identity in 143 aa overlap).	X2BIJ9,P64890,P64890	No	conserved hypotheticals			P64890					X2BIJ9,P64890					Rv1813c		Rv1813c			
NC_002945.3	Mycobrowser_v4	CDS	2047983	2048648	.	+	0	Mb1845	Mb1845		conserved protein	Mb1845, -, len: 221 aa. Equivalent to Rv1815, len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 221 aa overlap). Conserved hypothetical protein, similar to G473456 hypothetical protein from Mycobacterium fortuitum (255 aa), FASTA scores: opt: 182,E(): 3.2e-05, (29.6% identity in 230 aa overlap).	X2BIZ5,P59981,P59981	No	conserved hypotheticals			P59981					X2BIZ5,P59981					Rv1815		Rv1815			
NC_002945.3	Mycobrowser_v4	CDS	2050050	2051513	.	+	0	Mb1848	Mb1848		POSSIBLE FLAVOPROTEIN	Mb1848, -, len: 487 aa. Equivalent to Rv1817, len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 487 aa overlap). Possible flavoprotein, similar to G746486 flavoprotein subunit of fumarate reductase fad domain homologue (474 aa), FASTA scores: opt: 223, E(): 5.7e-07, (24.1% identity in 489 aa overlap); and AJ236923|SFR236923_3 soluble fumarate reductase of Shewanella frigidimarina ifcA (588 aa), FASTA scores: opt: 310, E(): 2.5e-11, (27.3% identity in 484 aa overlap).	Q7TZH1,A0A1R3XZD7	No	intermediary metabolism and respiration			A0A1R3XZD7				IPR003953,IPR027477	Q7TZH1					Rv1817		Rv1817			
NC_002945.3	Mycobrowser_v4	CDS	2060166	2061089	.	+	0	Mb1854	Mb1854		conserved protein	Mb1854, -, len: 307 aa. Equivalent to Rv1823, len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Conserved hypothetical protein, similar to P71582|MTCY10H4.12|RV0012 hypothetical protein CY10H4.12 from Mycobacterium tuberculosis (262 aa), FASTA scores: opt: 304, E(): 1.5e-12, (30.1% identity in 246 aa overlap).	X2BJ59,P64892,P64892	No	conserved hypotheticals			P64892					X2BJ59,P64892					Rv1823		Rv1823			
NC_002945.3	Mycobrowser_v4	CDS	2069281	2070141	.	-	0	Mb1864c	Mb1864c		Possible haloalkane dehalogenase	Mb1864c, -, len: 286 aa. Equivalent to Rv1833c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible haloalkane dehalogenase (EC 3.8.1.5). Similar to several haloalkane dehalogenase e.g. CAB45532.1|AJ243259 from Mycobacterium bovis (300 aa); also similar to LINB_PSEPA|P51698 1,3,4,6-tetrachloro-1,4-cyclohexadien from Pseudomonas paucimobilis (295 aa), FASTA scores: opt: 314, E(): 1.5e-13, (33.1% identity in 281 aa overlap).	X2BJ69,P64304,P64304	No	intermediary metabolism and respiration			P64304					X2BJ69,P64304					Rv1833c		Rv1833c			
NC_002945.3	Mycobrowser_v4	CDS	2071053	2072939	.	-	0	Mb1866c	Mb1866c		CONSERVED HYPOTHETICAL PROTEIN	Mb1866c, -, len: 628 aa. Equivalent to Rv1835c,len: 628 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 628 aa overlap). Conserved hypothetical protein, some similarity to putative acylases e.g. G216374 glutaryl 7-aca acylase precursor (634 aa) FASTA scores, opt: 202, E(): 3.5e-06, (25.1% identity in 669 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2800 and Rv1215c.	X2BJC0,P0A5F6,P0A5F6	No	conserved hypotheticals			P0A5F6					X2BJC0,P0A5F6					Rv1835c		Rv1835c			
NC_002945.3	Mycobrowser_v4	CDS	2080935	2082302	.	-	0	Mb1873c	Mb1873c		CONSERVED HYPOTHETICAL MEMBRANE PROTEIN	Mb1873c, -, len: 455 aa. Equivalent to Rv1842c,len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 455 aa overlap). Conserved hypothetical membrane protein. Similar to Z99109|0O7589 Potential integral membrane protein from Bacillus subtilis (461 aa),FASTA scores: opt: 723, E(): 0, (31.2% identity in 449 aa overlap). Similar to other Mycobacterium tuberculosis putative integral membrane proteins e.g. Rv2366c,Rv1841c.	Q7TZG2,A0A1R3XZW2	No	cell wall and cell processes			A0A1R3XZW2				IPR000644,IPR002550,IPR005170,IPR016166,IPR016169	Q7TZG2					Rv1842c		Rv1842c			
NC_002945.3	Mycobrowser_v4	CDS	2072955	2074988	.	-	0	Mb1867c	Mb1867c		conserved protein	Mb1867c, -, len: 677 aa. Equivalent to Rv1836c,len: 677 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 677 aa overlap). Conserved hypothetical protein. Equivalent to MLCB1788.28|AL008609 hypothetical protein from Mycobacterium leprae (710 aa), FASTA scores: opt: 2938, E(): 0, (66.0% identity in 714 aa overlap). Contains PS00036 bZIP transcription factors basic domain signature.	Q7TZG6,A0A1R3XZG5	No	conserved hypotheticals			A0A1R3XZG5				IPR002035	Q7TZG6					Rv1836c		Rv1836c			
NC_002945.3	Mycobrowser_v4	CDS	2113383	2113820	.	+	0	Mb1904	Mb1904		CONSERVED HYPOTHETICAL PROTEIN	Mb1904, -, len: 145 aa. Equivalent to Rv1873, len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 145 aa overlap). Conserved hypothetical protein. Some similarity to AL591783 hypothetical protein from Sinorhizobium meliloti.	Q7TZE3,A0A1R3XZK4	No	conserved hypotheticals			A0A1R3XZK4				IPR014937	Q7TZE3					Rv1873		Rv1873			
NC_002945.3	Mycobrowser_v4	CDS	2079886	2080935	.	-	0	Mb1872c	Mb1872c		CONSERVED HYPOTHETICAL MEMBRANE PROTEIN	Mb1872c, -, len: 349 aa. Equivalent to Rv1841c,len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 349 aa overlap). Conserved hypothetical membrane protein. Some similarity to O07585|YHDP_BACSU HYPOTHETICAL 49.9 KD PROTEIN from Bacillus subtilis (444 aa), FASTA scores: opt: 620, E(): 0, (31.1% identity in 350 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv1842c, Rv2366c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa).	Q7TZG3,A0A1R3XZI0	No	cell wall and cell processes			A0A1R3XZI0				IPR000644,IPR002550	Q7TZG3					Rv1841c		Rv1841c			
NC_002945.3	Mycobrowser_v4	CDS	2124498	2125097	.	-	0	Mb1917c	Mb1917c		chorismate mutase	Mb1917c, -, len: 199 aa. Equivalent to Rv1885c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Conserved hypothetical protein, some similarity to P42517|CHMU_ERWHE MONOFUNCTIONAL CHORISMATE MUTASE (181 aa), FASTA score: opt: 181, E(): 0.00017, (28.6% identity in 133 aa overlap).	Q7TZD2,A0A1R3XZL2	No	intermediary metabolism and respiration			A0A1R3XZL2				IPR002701,IPR008240,IPR020822	Q7TZD2					Rv1885c		Rv1885c			
NC_002945.3	Mycobrowser_v4	CDS	2087086	2087508	.	+	0	Mb1878	Mb1878		conserved protein	Mb1878, -, len: 140 aa. Equivalent to Rv1847, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 140 aa overlap=. Conserved hypothetical protein, possible thioesterase, some similarity to YBDB proteins of Escherichia coli and H. influenzae e.g. P15050|YBDB_ECOLI HYPOTHETICAL 15.0 KD PROTEIN IN ENTA-CSTA INTERGENIC REGION (137 aa), FASTA scores: opt: 232, E(): 6.6e-10, (35.8% identity in 106 aa overlap); C48956|G142208 thioesterase from Arthrobacter sp (151 aa),FASTA score: opt: 254, E(): 1.7e-11, (33.3% identity in 138 aa overlap). Also similar to AF064959|AF064959_1 hypothetical protein from Coxiella burnetii (148 aa),FASTA score: opt: 264, E(): 9.3e- 12, (36.8% identity in 117 aa overlap).	Q7TZF8,A0A1R3XZH4	No	conserved hypotheticals			A0A1R3XZH4				IPR003736,IPR006683	Q7TZF8					Rv1847		Rv1847			
NC_002945.3	Mycobrowser_v4	CDS	2093392	2094315	.	-	0	Mb1886c	Mb1886c		POSSIBLE OXIDOREDUCTASE	Mb1886c, -, len: 307 aa. Equivalent to Rv1855c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Possible oxidoreductase (EC 1.-.-.-), possibly a monooxygenase. Contains PS00217 Sugar transport proteins signature 2,probably fortuitously. Similar to G487716 (78-11) LINCOMYCIN PRODUCTION GENES (29.2% identity in 154 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, etc.	Q7TZF6,A0A1R3XZJ1	No	intermediary metabolism and respiration			A0A1R3XZJ1				IPR011251,IPR019952	Q7TZF6					Rv1855c		Rv1855c			
NC_002945.3	Mycobrowser_v4	CDS	2094354	2095031	.	-	0	Mb1887c	Mb1887c		POSSIBLE OXIDOREDUCTASE	Mb1887c, -, len: 225 aa. Equivalent to Rv1856c,len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 225 aa overlap). Possible oxidoreductase (EC 1.-.-.-). Equivalent to MLCB1788.11c|AL008609 OXIDOREDUCTASE from Mycobacterium leprae (224 aa), FASTA scores: opt: 1211, E(): 0; (80.4% identity in 224 aa overlap). Some similarity to dehydrogenases of short-chain dehydrogenase/reductase family and fatty-acyl CoA reductases e.g. P16543|DHK2_STRVN GRANATICIN POLYKETIDE SYNTHASE P (249 aa), FASTA score: opt: 194, E(): 1.1e-05, (32.5% identity in 237 aa overlap).	Q7TZF5,A0A1R3XZI6	No	intermediary metabolism and respiration			A0A1R3XZI6				IPR016040	Q7TZF5					Rv1856c		Rv1856c			
NC_002945.3	Mycobrowser_v4	CDS	2099373	2099678	.	+	0	Mb1892	Mb1892		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb1892, -, len: 101 aa. Equivalent to Rv1861, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Probable conserved transmembrane protein, showing weak similarity to AE002069|AE002069_10 hypothetical protein from Deinococcus radiodurans (146 aa), FASTA scores: opt: 154, E(): 0.0027,(30.8% identity in 104 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TZF3,A0A1R3XZK0	No	cell wall and cell processes			A0A1R3XZK0				IPR007341	Q7TZF3					Rv1861		Rv1861			
NC_002945.3	Mycobrowser_v4	CDS	2101563	2102318	.	-	0	Mb1895c	Mb1895c		conserved protein	Mb1895c, -, len: 251 aa. Equivalent to Rv1864c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Conserved hypothetical protein. Similar to other hypothetical proteins e.g. AL031317|SC6G4.43 from Streptomyces coelicolor cosmid 6G (233 aa), FASTA scores: opt: 716,E(): 0, (54.4% identity in 215 aa overlap); also P43976|YIIM_HAEIN hypothetical protein hi0278 (221 aa),FASTA scores: opt: 223, E(): 3.8e-08, (29.5% identity in 173 aa overlap).	Q7TZF1,A0A1R3XZM6	No	conserved hypotheticals			A0A1R3XZM6				IPR005163,IPR005302,IPR011037,IPR015808	Q7TZF1					Rv1864c		Rv1864c			
NC_002945.3	Mycobrowser_v4	CDS	2245337	2245636	.	-	0	Mb2043c	Mb2043c		CONSERVED HYPOTHETICAL PROTEIN	Mb2043c, -, len: 99 aa. Equivalent to Rv2020c, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein, nearly identical to C-terminal part of hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds to deletion region RvD1 so probably truncated protein.	Q7TZ53,A0A1R3Y013	No	conserved hypotheticals			A0A1R3Y013					Q7TZ53					Rv2020c		Rv2020c			
NC_002945.3	Mycobrowser_v4	CDS	2102315	2103175	.	-	0	Mb1896c	Mb1896c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE	Mb1896c, -, len: 286 aa. Equivalent to Rv1865c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable short-chain dehydrogenase (EC 1.-.-.-), highly similar to C-terminus of NP_301650.1|NC_00267 putative oxidoreductase from Mycobacterium leprae (596 aa). Also similar to various dehydrogenases, generally belonging to short-chain family,e.g. AAG02168.1|AF212041_24|AF212041 3-oxoacyl-(acylcarrier protein) reductase from Zymomonas mobilis (251 aa); P50198|LINX_PSEPA 2,5-DICHLORO-2,5-CYCLOHEXADIENE-1,4-DIOL DEHYDROGENASE from Sphingomonas paucimobilis (250 aa); NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar to acetoin reductase) from Mesorhizobium loti (256 aa); etc. And highly similar to C-terminus of ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis (592 aa); and many other oxidoreductases from Mycobacterium tuberculosis e.g. Y00P_MYCTU|Q10402 putative oxidoreductase (650 aa), FASTA scores: opt: 439, E(): 8.9e-20, (32.5% identity in 280 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TZF0,A0A1R3XZJ8	No	intermediary metabolism and respiration			A0A1R3XZJ8				IPR002198,IPR002347,IPR016040,IPR020904	Q7TZF0					Rv1865c		Rv1865c			
NC_002945.3	Mycobrowser_v4	CDS	2103349	2105685	.	+	0	Mb1897	Mb1897		conserved protein	Mb1897, -, len: 778 aa. Equivalent to Rv1866, len: 778 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 778 aa overlap). Conserved hypothetical protein, N-terminal region similar to fatty acyl-CoA racemases e.g. Rv0855, Rv1143, and C-terminal region (from aa 370) similar to L-carnitine dehydratases, racemases,and Rv3272|MTCY71.12 Mycobacterium tuberculosis (394 aa),FASTA score: opt: 472, E(): 2.1e-21, (29.9% identity in 388 aa overlap). Also similar to P31572|CAIB_ECOLI L-CARNITINE DEHYDRATASE (EC 4.2.1.89) (405 aa), FASTA score: opt: 306, E(): 2.1e-11, (23.3% identity in 424 aa overlap).	Q7TZE9,A0A1R3XZJ5	No	lipid metabolism			A0A1R3XZJ5				IPR003673,IPR023606	Q7TZE9					Rv1866		Rv1866			
NC_002945.3	Mycobrowser_v4	CDS	3458054	3458386	.	-	0	Mb3160A	Mb3160A		Conserved protein	Mb3160A, len: 110 aa. Equivalent to Rv3136A len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BNH3	No	conserved hypotheticals								X2BNH3	A0A1R3Y3E3				Rv3136A		Rv3136A			
NC_002945.3	Mycobrowser_v4	CDS	2105973	2107457	.	+	0	Mb1898	Mb1898		conserved protein	Mb1898, -, len: 494 aa. Equivalent to Rv1867, len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 494 aa overlap). Conserved hypothetical protein, some similarity to acetyl CoA synthase and to lipid carriers. FASTA best: E155295 acetyl CoA synthase (388 aa), opt: 213, E(): 4.5e-07, (23.2% identity in 423 aa overlap).	Q7TZE8,A0A1R3XZK6	No	lipid metabolism			A0A1R3XZK6				IPR002155,IPR016038,IPR016039	Q7TZE8					Rv1867		Rv1867			
NC_002945.3	Mycobrowser_v4	CDS	2227479	2228336	.	-	0	Mb2026c	Mb2026c		CONSERVED HYPOTHETICAL PROTEIN	Mb2026c, -, len: 285 aa. Equivalent to Rv2003c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 285 aa overlap). Conserved hypothetical protein. Some similarity with Methanococcus jannaschii 67555|U67555_3 (205 aa), FASTA scores: opt: 357, E(): 3.2e-17, (33.8% identity in 204 aa overlap).	X2BJU1,P64920,P64920	No	conserved hypotheticals			P64920					X2BJU1,P64920					Rv2003c		Rv2003c			
NC_002945.3	Mycobrowser_v4	CDS	2107556	2109655	.	+	0	Mb1899	Mb1899		CONSERVED HYPOTHETICAL PROTEIN	Mb1899, -, len: 699 aa. Equivalent to Rv1868, len: 699 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 699 aa overlap). Conserved hypothetical protein, similar to products of three consecutive ORFS in Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt: 314,E(): 9.9e-12, (35.2% identity in 213 aa overlap); MLCB2052.17, and MLCB2052.16. Also similar to M. tuberculosis hypothetical protein Rv2047c.	Q7TZE7,A0A1R3XZJ6	No	conserved hypotheticals			A0A1R3XZJ6				IPR016040	Q7TZE7					Rv1868		Rv1868			
NC_002945.3	Mycobrowser_v4	CDS	2109669	2110904	.	-	0	Mb1900c	Mb1900c		Probable reductase	Mb1900c, -, len: 411 aa. Equivalent to Rv1869c,len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 411 aa overlap). Probable reductase (1.-.-.-). Similar to several reductases e.g. CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494 rhodocoxin reductase (426 aa), FASTA scores: opt: 904,E(): 0, (40.8% identity in 370 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv0688 (406 aa) (39.9% identity in 391 aa overlap); and Rv0253 (nitrite reductase subunit).	Q7VET3,A0A1R3Y1Q6	No	intermediary metabolism and respiration			A0A1R3Y1Q6				IPR001327,IPR004099,IPR013027,IPR016156,IPR023753,IPR028202	Q7VET3					Rv1869c		Rv1869c			
NC_002945.3	Mycobrowser_v4	CDS	4133018	4133401	.	+	0	Mb3773	Mb3773		conserved protein	Mb3773, -, len: 127 aa. Equivalent to Rv3747, len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Hypothetical protein,highly similar to downstream ORF O69715|Rv3748|MTV025.096 CONSERVED HYPOTHETICAL PROTEIN (119 aa), FASTA scores: opt: 494, E(): 6e-27, (64.4% identity in 118 aa overlap).	Q7TVS6,A0A1R3Y536	No	conserved hypotheticals			A0A1R3Y536					Q7TVS6					Rv3747		Rv3747			
NC_002945.3	Mycobrowser_v4	CDS	2110971	2111639	.	-	0	Mb1901c	Mb1901c		CONSERVED HYPOTHETICAL PROTEIN	Mb1901c, -, len: 222 aa. Equivalent to Rv1870c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Conserved hypothetical protein. Some similarity to SC6F7.17c hypothetical protein from Streptomyces coelicolor (216 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (t-a) and a single base transition (c-t) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa).	Q7TZE6,A0A1R3Y0D9	No	conserved hypotheticals			A0A1R3Y0D9				IPR011257	Q7TZE6					Rv1870c		Rv1870c			
NC_002945.3	Mycobrowser_v4	CDS	2111704	2112093	.	-	0	Mb1902c	Mb1902c		conserved protein	Mb1902c, -, len: 129 aa. Equivalent to Rv1871c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Q11057|Rv1261|MTCY50.21 (149 aa), FASTA score: opt: 125, E(): 0.019, (32.6% identity in 89 aa overlap); Rv0523c, and Rv1598c.	Q7TZE5,A0A1R3XZL5	No	conserved hypotheticals			A0A1R3XZL5				IPR004378,IPR012349	Q7TZE5					Rv1871c		Rv1871c			
NC_002945.3	Mycobrowser_v4	CDS	2122580	2123413	.	-	0	Mb1914c	Mb1914c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb1914c, -, len: 277 aa. Equivalent to Rv1882c,len: 277 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 277 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_250789.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (251 aa); NP_421760.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (270 aa); NP_107167.1|NC_002678 oxidoreductase (short chain dehydrogenase/reductase family) from Mesorhizobium loti (253 aa); P50197|LINC_PSEPA 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa), FASTA scores: opt: 301, E(): 2.3e-12, (30.0% identity in 223 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3057c, Rv1245, etc. Contains possible helix-turn-helix motif at aa 246-267 (+4.32 SD). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TZD5,A0A1R3XZL1	No	intermediary metabolism and respiration			A0A1R3XZL1				IPR002198,IPR002347,IPR016040,IPR020904	Q7TZD5					Rv1882c		Rv1882c			
NC_002945.3	Mycobrowser_v4	CDS	2114590	2115033	.	+	0	Mb1906	Mb1906		conserved protein	Mb1906, -, len: 147 aa. Equivalent to Rv1875, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178,E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09, (38.7% identity in 137 aa overlap).	Q7TZE1,A0A1R3XZL6	No	conserved hypotheticals			A0A1R3XZL6				IPR011576,IPR012349,IPR019920	Q7TZE1					Rv1875		Rv1875			
NC_002945.3	Mycobrowser_v4	CDS	2116113	2117648	.	+	0	Mb1908	Mb1908		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [FIRST PART]	Mb1908, -, len: 511 aa. Similar to 5' end of Rv1877, len: 687 aa, from Mycobacterium tuberculosis strain H37Rv, (93.2% identity in 292 aa overlap). Probable conserved integral membrane protein, part of major facilitator superfamily (MFS), similar to many antibiotic and drug efflux proteins. Similar to e.g. Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE from Streptomyces violaceoruber (557 aa), FASTA scores: opt: 895, E(): 0, (34.7% identity in 528 aa overlap). Also similar to Mycobacterium tuberculosis relatives protein, include Rv3728, Rv3239c,Rv2846c, etc. Contains PS00217 Sugar transport proteins signature 2 (PS00217). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts,Mb1908 and Mb1909.	Q7TZE0,A0A1R3XZL3	No				A0A1R3XZL3				IPR001958,IPR005829,IPR011701,IPR016196,IPR020846	Q7TZE0										
NC_002945.3	Mycobrowser_v4	CDS	2116963	2118177	.	+	0	Mb1909	Mb1909		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [SECOND PART]	Mb1909, -, len: 404 aa. Equivalent to 3' end of Rv1877, len: 687 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 404 aa overlap). Probable conserved integral membrane protein, part of major facilitator superfamily (MFS), similar to many antibiotic and drug efflux proteins. Similar to e.g. Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE from Streptomyces violaceoruber (557 aa), FASTA scores: opt: 895, E(): 0,(34.7% identity in 528 aa overlap). Also similar to Mycobacterium tuberculosis relatives protein, include Rv3728, Rv3239c, Rv2846c, etc. Contains PS00217 Sugar transport proteins signature 2 (PS00217). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts, Mb1908 and Mb1909.	Q7TZD9,A0A1R3XZK3	No				A0A1R3XZK3				IPR011991,IPR016196,IPR020846	Q7TZD9										
NC_002945.3	Mycobrowser_v4	CDS	2119587	2120723	.	+	0	Mb1911	Mb1911		CONSERVED HYPOTHETICAL PROTEIN	Mb1911, -, len: 378 aa. Equivalent to Rv1879, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). Conserved hypothetical protein, similar to SCC22.14c|AL096839 hypothetical protein from Streptomyces coelicolor (368 aa), FASTA results: opt: 772, E(): 0 (40.3% identity in 372 aa overlap); and to N-terminal half of nodulin/glutamate-ammonia ligase-like protein. Some similarity to N-terminus of AL132958|ATT4D2_11 Arabidopsis thaliana (845 aa), FASTA results: opt: 354, E(): 3.1e-16,(29.2% identity in 383 aa overlap); and to P38094|FLUG_EMENI Flug protein of Emericella nidulans (865 aa), FASTA results: opt: 306, E(): 6.2e-13, (26.5% identity in 415 aa overlap). Note that the upstream ORF Rv1878|MTCY18 0.40c is similar to the C-terminus.	Q7TZD7,A0A1R3Y0F1	No	conserved hypotheticals			A0A1R3Y0F1				IPR006992	Q7TZD7					Rv1879		Rv1879			
NC_002945.3	Mycobrowser_v4	CDS	2123441	2123917	.	-	0	Mb1915c	Mb1915c		CONSERVED HYPOTHETICAL PROTEIN	Mb1915c, -, len: 158 aa. Equivalent to Rv1883c,len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(96.8% identity in 158 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins e.g. Rv2778c|AL008967|MTV002.43 from Mycobacterium tuberculosis (156 aa), FASTA score: opt: 212, E(): 3.1e-08, (34.4% identity in 151 aa overlap). Also similar to U75434|SAU75434_3 Nsh-OrfB from Streptomyces actuosus (173 aa), FASTA score: opt: 207, E(): 1.8e-07, (40.2% identity in 102 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa).	Q7TZD4,A0A1R3XZN9	No	conserved hypotheticals			A0A1R3XZN9				IPR019587,IPR023393	Q7TZD4					Rv1883c		Rv1883c			
NC_002945.3	Mycobrowser_v4	CDS	2126483	2127625	.	+	0	Mb1919	Mb1919		HYPOTHETICAL PROTEIN	Mb1919, -, len: 380 aa. Equivalent to Rv1887, len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 380 aa overlap). Hypothetical unknown protein; contains eukaryotic thiol (cysteine) proteases histidine active site at N-terminus (PS00639) and Pro-rich region near C-terminus.	Q7TZD1,A0A1R3XZK9	No	conserved hypotheticals			A0A1R3XZK9					Q7TZD1					Rv1887		Rv1887			
NC_002945.3	Mycobrowser_v4	CDS	2247184	2247861	.	-	0	Mb2047c	Mb2047c		HYPOTHETICAL PROTEIN	Mb2047c, -, len: 225 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT2080, len: 225 aa, from Mycobacterium tuberculosis strain CDC1551, (100.0% identity in 225 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv.	Q7TZ49,A0A1R3Y244	No				A0A1R3Y244					Q7TZ49										
NC_002945.3	Mycobrowser_v4	CDS	2127595	2128314	.	-	0	Mb1920c	Mb1920c		POSSIBLE TRANSMEMBRANE PROTEIN	Mb1920c, -, len: 239 aa. Similar to Rv1888c, len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Possible transmembrane protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 10 bp insertion (*-tccgatcacc) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa).	Q7TZD0,A0A1R3Y1S2	No				A0A1R3Y1S2				IPR025498	Q7TZD0										
NC_002945.3	Mycobrowser_v4	CDS	2128679	2128852	.	-	0	Mb1921c	Mb1921c		CONSERVED HYPOTHETICAL PROTEIN	Mb1921c, -, len: 57 aa. Equivalent to Rv1888A, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Conserved hypothetical protein. Possibly continuation of Rv1889c, part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~ 120 aa. Includes: C-terminus of Rv0726c|P95074 CONSERVED HYPOTHETICAL PROTEIN (367 aa), FASTA scores: opt: 295, E(): 3.1e-15,(73.684% identity in 57 aa overlap); C-terminus of Rv3399|Q50726|MTCY78.29c CONSERVED HYPOTHETICAL PROTEIN (348 aa), FASTA scores: opt: 504, E(): 7.3e-29, (64.2% identity in 120 aa overlap); C-terminus of Rv0731c; etc.	Q7TZC9,A0A1R3Y0F9	No	conserved hypotheticals			A0A1R3Y0F9				IPR007213	Q7TZC9					Rv1888A		Rv1888A			
NC_002945.3	Mycobrowser_v4	CDS	2128896	2129252	.	-	0	Mb1922c	Mb1922c		CONSERVED HYPOTHETICAL PROTEIN	Mb1922c, -, len: 118 aa. Equivalent to Rv1889c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein. Part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~ 120 aa. Includes: Rv3399|Q50726|MTCY78.29C hypothetical 38.1 kd protein (348 aa), FASTA results: opt: 504, E(): 7.3e-29, (64.2% identity in 120 aa overlap); Rv0726c, Rv0731c, etc.	Q7TZC8,A0A1R3XZN6	No	conserved hypotheticals			A0A1R3XZN6				IPR007213	Q7TZC8					Rv1889c		Rv1889c			
NC_002945.3	Mycobrowser_v4	CDS	2130974	2132104	.	-	0	Mb1927c	Mb1927c		CONSERVED HYPOTHETICAL PROTEIN	Mb1927c, -, len: 376 aa. Equivalent to Rv1894c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Conserved hypothetical protein, weak similarity to some oxidoreductases e.g. Q01284 2-NITROPROPANE DIOXYGENASE PRECURSOR (378 aa), FASTA results: opt: 204, E(): 5.8e-06,(34.3% identity in 140 aa overlap). Similar to hypothetical Mycobacterium tuberculosis proteins e.g. Rv3553|MTCY03C7.02c (355 aa), FASTA results: opt: 296,E(): 1.6e-10, (32.9% identity in 167 aa overlap); Rv1533 (375 aa) (48.1% identity in 376 aa overlap); Rv0021c,Rv2781c.	Q7TZC3,A0A1R3XZM5	No	conserved hypotheticals			A0A1R3XZM5				IPR004136,IPR013785	Q7TZC3					Rv1894c		Rv1894c			
NC_002945.3	Mycobrowser_v4	CDS	2143515	2144162	.	-	0	Mb1942c	Mb1942c		HYPOTHETICAL PROTEIN	Mb1942c, -, len: 215 aa. Equivalent to Rv1907c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Hypothetical unknown protein. Similar to Q50763 Ethyl methane sulphonate resistance protein from Mycobacterium tuberculosis (168 aa), FASTA scores: opt: 638, E(): 0, (69.7% identity in 152 aa overlap). Downstream of a cloned katG gene (EMBL:MTKATG). Differences are due to frameshift errors in the EMBL sequence and the use of an earlier start codon.	Q7TZB2,A0A1R3Y0H4	No	conserved hypotheticals			A0A1R3Y0H4				IPR025358	Q7TZB2					Rv1907c		Rv1907c			
NC_002945.3	Mycobrowser_v4	CDS	2132756	2133079	.	+	0	Mb1928	Mb1928		POSSIBLE DEHYDROGENASE [FIRST PART]	Mb1928, -, len: 107 aa. Equivalent to 5' end of Rv1895, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 96 aa overlap). Possible dehydrogenase (EC 1.1.-.-), similar to various sorbitol and alcohol dehydrogenases, and to putative glutathione-dependent aldehyde dehydrogenase e.g DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from Streptomyces coelicolor (352 aa), FASTA results: opt: 506, E(): 7.2e-24, (30.6% identity in 350 aa overlap); and AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE from Streptomyces coelicolor (356 aa), FASTA results: opt: 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also similar to other Mycobacterium tuberculosis dehydrogenases. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t),consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929.	Q7TZC2,A0A1R3XZP1	No				A0A1R3XZP1				IPR002085,IPR002328,IPR011032,IPR013154	Q7TZC2										
NC_002945.3	Mycobrowser_v4	CDS	2133076	2133780	.	+	0	Mb1929	Mb1929		POSSIBLE DEHYDROGENASE [SECOND PART]	Mb1929, -, len: 234 aa. Equivalent to middle part of Rv1895, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 234 aa overlap). Possible dehydrogenase (EC 1.1.-.-), similar to various sorbitol and alcohol dehydrogenases, and to putative glutathione-dependent aldehyde dehydrogenase e.g DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from Streptomyces coelicolor (352 aa), FASTA results: opt: 506, E(): 7.2e-24, (30.6% identity in 350 aa overlap); and AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE from Streptomyces coelicolor (356 aa), FASTA results: opt: 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also similar to other Mycobacterium tuberculosis dehydrogenases. ****Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t),consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929.	Q7TZC1,A0A1R3XZM8	No				A0A1R3XZM8				IPR002085,IPR011032,IPR013149,IPR016040	Q7TZC1										
NC_002945.3	Mycobrowser_v4	CDS	570951	571475	.	-	0	Mb0491c	Mb0491c		HYPOTHETICAL PROTEIN	Mb0491c, -, len: 174 aa. Equivalent to Rv0481c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Hypothetical unknown protein.	X2BF55,P64702	No	conserved hypotheticals			P64702					X2BF55					Rv0481c		Rv0481c			
NC_002945.3	Mycobrowser_v4	CDS	2133770	2134681	.	-	0	Mb1931c	Mb1931c		CONSERVED HYPOTHETICAL PROTEIN	Mb1931c, -, len: 303 aa. Equivalent to Rv1896c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Conserved hypothetical protein. Similar to several (14) hypothetical Mycobacterium tuberculosis proteins e.g. Rv0145|MTCI5.19 (317 aa), FASTA results: opt: 720, E(): 0, (41.6% identity in 308 aa overlap); Q10552|YZ21_MYCTU (325 aa), opt: 689,E(): 0, (40.5% identity in 304 aa overlap); Rv0726c,Rv0731c, Rv3399, etc. and to related proteins in other actinomycetes. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions.	X2BJ91,Q7TZC0,Q7TZC0	No	conserved hypotheticals			Q7TZC0					X2BJ91,Q7TZC0					Rv1896c		Rv1896c			
NC_002945.3	Mycobrowser_v4	CDS	2135175	2135483	.	+	0	Mb1933	Mb1933		CONSERVED HYPOTHETICAL PROTEIN	Mb1933, -, len: 102 aa. Equivalent to Rv1898, len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. Q58452 from METHANOCOCCUS JANNASCH II (100 aa), FASTA results: opt: 152, E(): 9.1e-05, (31.5% identity in 92 aa overlap); and AE000771|AE000771_2 from Aquifex aeolicus (157 aa), FASTA results: opt: 246, E(): 3.2e-11, (39.0% identity in 100 aa overlap).	X2BJC9,P67120	No	conserved hypotheticals			P67120					X2BJC9					Rv1898		Rv1898			
NC_002945.3	Mycobrowser_v4	CDS	2165702	2166817	.	+	0	Mb1957	Mb1957		PROBABLE CONSERVED LIPOPROTEIN	Mb1957, -, len: 371 aa. Equivalent to Rv1922, len: 371 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 371 aa overlap). Probable conserved lipoprotein, possibly peptidase (EC 3.4.-.-) similar to many peptidases, e.g. P15555|DAC_STRSQ D-alanyl-D-alanine carboxypeptidase from Streptomyces sp. (406 aa), FASTA scores: opt: 382, E(): 3.1e-17, (28.0% identity in 379 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TZA2,A0A1R3XZQ7	No	cell wall and cell processes			A0A1R3XZQ7				IPR001466,IPR012338	Q7TZA2					Rv1922		Rv1922			
NC_002945.3	Mycobrowser_v4	CDS	2140644	2141048	.	+	0	Mb1938	Mb1938		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb1938, -, len: 134 aa. Equivalent to Rv1903, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Probable conserved membrane protein, similar to Q53868|YPT3_STRCO hypothetical 15.9 kd protein from Streptomyces coelicolor (148 aa) opt: 323, E(): 1.3e-16, (42.9% identity in 126 aa overlap); and equivalent to AJ000521|MLCOSL672_3 from Mycobacterium leprae (139 aa), FASTA results: opt: 680,E(): 0, (80.6% identity in 129 aa overlap).	Q7TZB6,A0A1R3XZN5	No	cell wall and cell processes			A0A1R3XZN5				IPR007165	Q7TZB6					Rv1903		Rv1903			
NC_002945.3	Mycobrowser_v4	CDS	2141234	2141665	.	+	0	Mb1939	Mb1939		CONSERVED HYPOTHETICAL PROTEIN	Mb1939, -, len: 143 aa. Equivalent to Rv1904, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 143 aa overlap). Conserved hypothetical protein, some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt: 456, E( ): 2.7e-23, (52.8% identity in 125 aa overlap); Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E(): 1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c. Also weak similarity to Q9WVX8|RSBV_STRCO ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa).	Q7TZB5,A0A1R3XZQ1	No	conserved hypotheticals			A0A1R3XZQ1				IPR002645,IPR003658	Q7TZB5					Rv1904		Rv1904			
NC_002945.3	Mycobrowser_v4	CDS	2246665	2247024	.	-	0	Mb2046c	Mb2046c		HYPOTHETICAL PROTEIN	Mb2046c, -, len: 119 aa. Equivalent to Rv2023c,len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical protein,alternative upstream start possible.	Q7TZ50,A0A1R3XZZ5	No	conserved hypotheticals			A0A1R3XZZ5					Q7TZ50					Rv2023c		Rv2023c			
NC_002945.3	Mycobrowser_v4	CDS	2149471	2150223	.	+	0	Mb1948	Mb1948		CONSERVED HYPOTHETICAL PROTEIN	Mb1948, -, len: 250 aa. Equivalent to Rv1913, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Conserved hypothetical protein, slight similarity to dehydrase and beta-lactamase precursors e.g. Q02057 DEHYDRASE from Streptomyces coelicolor (297 aa), FASTA scores: opt: 184,E(): 4.3e-05, (31.6% identity in 215 aa overlap).	Q7TZB0,A0A1R3XZP2	No	conserved hypotheticals			A0A1R3XZP2				IPR001279	Q7TZB0					Rv1913		Rv1913			
NC_002945.3	Mycobrowser_v4	CDS	2150201	2150608	.	-	0	Mb1949c	Mb1949c		unknown protein	Mb1949c, -, len: 135 aa. Equivalent to Rv1914c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Hypothetical unknown protein.	Q7TZA9,A0A1R3XZS2	No	conserved hypotheticals			A0A1R3XZS2					Q7TZA9					Rv1914c		Rv1914c			
NC_002945.3	Mycobrowser_v4	CDS	2172897	2173541	.	-	0	Mb1964c	Mb1964c		CONSERVED HYPOTHETICAL PROTEIN	Mb1964c, -, len: 214 aa. Equivalent to Rv1929c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(99.533% identity in 214 aa overlap). Conserved hypothetical protein, similar to SC4G6.14|AL096884 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 416, E(): 2.4e-22, (39.8% identity in 206 aa overlap).	I3NIG2,A0A1R3Y060	No	conserved hypotheticals			A0A1R3Y060				IPR017517,IPR017519	I3NIG2					Rv1929c		Rv1929c			
NC_002945.3	Mycobrowser_v4	CDS	2557099	2557530	.	-	0	Mb2332c	Mb2332c		HYPOTHETICAL GLYCINE RICH PROTEIN	Mb2332c, -, len: 143 aa. Equivalent to Rv2307B,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Hypothetical unknown Gly- rich protein. Equivalent to AAK46653 from Mycobacterium tuberculosis strain CDC1551 (133 aa) but longer 10 aa.	Q7TYV0,A0A1R3Y2Z9	No	conserved hypotheticals			A0A1R3Y2Z9					Q7TYV0					Rv2307B		Rv2307B			
NC_002945.3	Mycobrowser_v4	CDS	2162696	2163160	.	-	0	Mb1954c	Mb1954c		conserved protein	Mb1954c, -, len: 154 aa. Equivalent to Rv1919c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Conserved hypothetical protein, shows weak similarity to several major pollen antigens e.g. Z72431|BVGC25_1 MAJOR ALLERGEN BET V 1 from Betula verrucosa (160 aa), FASTA scores: opt: 133, E(): 0.012, (26.8% identity in 149 aa overlap). Also shows some similarity to Rv2574|MTCY227.27C Hypothetical protein from Mycobacterium tuberculosis (167 aa), (27.4% identity in 124 aa overlap).	Q7TZA5,A0A1R3Y050	No	conserved hypotheticals			A0A1R3Y050				IPR019587,IPR023393	Q7TZA5					Rv1919c		Rv1919c			
NC_002945.3	Mycobrowser_v4	CDS	2163258	2164121	.	+	0	Mb1955	Mb1955		PROBABLE MEMBRANE PROTEIN	Mb1955, -, len: 287 aa. Equivalent to Rv1920, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). Probable membrane protein, similar to AL0215|SC10A5.04 putative membrane protein from Streptomyces coelicolor cosmid 10A5 (295 aa),FASTA scores: opt: 292, E(): 3.6e-13, (31.3% identity in 243 aa overlap). Also weakly similar to several Mycobacterial putative proteins with unknown function e.g. Rv0502, Rv1428c, U00018_22 Mycobacterium leprae cosmid B2168.	Q7TZA4,A0A1R3XZR3	No	cell wall and cell processes			A0A1R3XZR3				IPR002123,IPR016676	Q7TZA4					Rv1920		Rv1920			
NC_002945.3	Mycobrowser_v4	CDS	2168185	2168565	.	-	0	Mb1959c	Mb1959c		unknown protein	Mb1959c, -, len: 126 aa. Equivalent to Rv1924c,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Hypothetical unknown protein.	Q7TZA0,A0A1R3XZT1	No	conserved hypotheticals			A0A1R3XZT1					Q7TZA0					Rv1924c		Rv1924c			
NC_002945.3	Mycobrowser_v4	CDS	2171308	2172081	.	+	0	Mb1962	Mb1962		CONSERVED HYPOTHETICAL PROTEIN	Mb1962, -, len: 257 aa. Equivalent to Rv1927, len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Conserved hypothetical protein, similar to SCG11A.10c|AL133210 hypothetical protein from Streptomyces coelicolor (252 aa), FASTA scores: opt: 729, E(): 0, (48.3% identity in 238 aa overlap). Slight similarity with P54543|YQJF_BACSU hypothetical 23.9 kd protein from Bacillus subtilis (209 aa), FASTA scores, opt: 230, E(): 2.8e-08, (28.0% identity in 164 aa overlap).	Q7TZ98,A0A1R3Y0J4	No	conserved hypotheticals			A0A1R3Y0J4				IPR018644	Q7TZ98					Rv1927		Rv1927			
NC_002945.3	Mycobrowser_v4	CDS	2172085	2172852	.	-	0	Mb1963c	Mb1963c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb1963c, -, len: 255 aa. Equivalent to Rv1928c,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to others e.g. NP_228109.1|NC_000853 oxidoreductase (short chain dehydrogenase/reductase family) from Thermotoga maritima (257 aa); T41116 short chain dehydrogenase from Schizosaccharomyces pombe (261 aa); P87219|SOU1_CANAL SORBITOL UTILIZATION PROTEIN (SDR FAMILY) from Candida albicans (281 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 541, E(): 1.2e-27, (37.5% identity in 251 aa overlap); etc. Also similar to many mycobacterial tuberculosis proteins e.g. Rv1350, Rv0927c,Rv2002, Rv0769, Rv2766c, etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TZ97,A0A1R3XZS7	No	intermediary metabolism and respiration			A0A1R3XZS7				IPR002198,IPR002347,IPR016040,IPR020904	Q7TZ97					Rv1928c		Rv1928c			
NC_002945.3	Mycobrowser_v4	CDS	2173553	2174077	.	-	0	Mb1965c	Mb1965c		CONSERVED HYPOTHETICAL PROTEIN	Mb1965c, -, len: 174 aa. Equivalent to Rv1930c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 174 aa overlap). Conserved hypothetical protein, similar to SC5F2A.30|AL049587 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 307, E(): 2.8e-13, (54.8% identity in 84 aa overlap). Some similarity to M. tuber culosis hypothetical protein Rv0052|MTCY21D4.15 (43% identity in 93 aa overlap).	I3NIF3,A0A1R3XZR9	No	conserved hypotheticals			A0A1R3XZR9				IPR025628	I3NIF3					Rv1930c		Rv1930c			
NC_002945.3	Mycobrowser_v4	CDS	2174095	2174874	.	-	0	Mb1966c	Mb1966c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb1966c, -, len: 259 aa. Equivalent to Rv1931c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Probable transcriptional regulatory protein. Similarity in C-terminal half to transcriptional activators e.g. Q43970 ARAC-LIKE PROTEIN (227 aa), FASTA scores: opt: 238, E(): 7.1e-07, (42.4% identity in 92 aa overlap). Similar to many probable transcription regulators in Streptomyces e.g. AL049587|SC5F2A.29 Streptomyces coelicolor (325 aa),FASTA scores: opt: 387, E(): 3.2e-16, (34.4% identity in 259 aa overlap).	I3NIF7,A0A1R3XZS8	No	regulatory proteins			A0A1R3XZS8				IPR009057,IPR018060,IPR025628	I3NIF7					Rv1931c		Rv1931c			
NC_002945.3	Mycobrowser_v4	CDS	2248256	2249152	.	-	0	Mb2048c	Mb2048c		HYPOTHETICAL PROTEIN	Mb2048c, -, len: 298 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT2081, len: 311 aa, from Mycobacterium tuberculosis strain CDC1551, (99.66% identity in 298 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv.	Q7TZ48,A0A1R3Y0R8	No				A0A1R3Y0R8					Q7TZ48										
NC_002945.3	Mycobrowser_v4	CDS	2191632	2191823	.	-	0	Mb1985c	Mb1985c		CONSERVED HYPOTHETICAL PROTEIN	Mb1985c, -, len: 63 aa. Equivalent to Rv1950c, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Conserved hypothetical protein, partial ORF. Highly similar to N-terminus of Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd protein (323 aa), FASTA scores: opt: 280, E(): 1.2 e-16, (71.7% identity in 53 aa overlap) but homology continues in different frame ie MTCY09F9.15, cosmid sequence appears to be correct, genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97.	Q7TZ82,A0A1R3XZT4	No	conserved hypotheticals			A0A1R3XZT4					Q7TZ82					Rv1950c		Rv1950c			
NC_002945.3	Mycobrowser_v4	CDS	2179019	2180128	.	+	0	Mb1971	Mb1971		POSSIBLE MONOOXYGENASE	Mb1971, -, len: 369 aa. Equivalent to Rv1936, len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Possible monooxygenase (EC 1.-.-.-), similar to LXA2_PHOLU|P23146 alkanal monooxygenase alpha chain (362 aa), FASTA scores: opt: 196, E(): 6.3e-06, (22.3% identity in 373 aa overlap). Also similar to many other Mycobacterium tuberculosis hypothetical oxidoreductases and monooxygenases e.g. Rv0953c, Rv0791c, Rv0132c, etc.	Q7TZ96,A0A1R3Y1V8	No	intermediary metabolism and respiration			A0A1R3Y1V8				IPR011251	Q7TZ96					Rv1936		Rv1936			
NC_002945.3	Mycobrowser_v4	CDS	2180131	2182650	.	+	0	Mb1972	Mb1972		POSSIBLE OXYGENASE	Mb1972, -, len: 839 aa. Equivalent to Rv1937, len: 839 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 839 aa overlap). Possible oxygenase (EC 1.-.-.-), similar in N-terminus to N-terminal part (approx. 350 aa) of dioxygenases (including ring-hydroxylating dioxygenase electron transfer components) and monooxygenases, e.g. AAC34815.1|AF071556 anthranilate dioxygenase reductase from Acinetobacter sp. (343 aa); AAK52291.1|AY026914|AntC putative anthranilate dioxygenase reductase from Pseudomonas putida (340 aa); AAF63450.1|AF218267_7|AF218267 benzoate dioxygenase / ferredoxin reductase from Pseudomonas putida (336 aa); P23101|XYLZ_PSEPU toluate 1,2-dioxygenase electron transfer component [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE (EC 1.18.1.3)] from Pseudomonas putida plasmid TOL pWW0 (336 aa), FASTA scores: opt: 700, E(): 0, (34.3% identity in 335 aa overlap); S23479 probable benzoate 1,2-dioxygenase (EC 1.14.12.10) reductase component benC from Acinetobacter calcoaceticus (338 aa); AAC45294.1|U81594 soluble methane monooxygenase protein C from Methylocystis sp. (343 aa); P22868|MEMC_METCA METHANE MONOOXYGENASE COMPONENT C from Methylococcus capsulatus (348 aa); etc. Also similar in part to Mycobacterium tuberculosis hypothetical electron transfer proteins Rv3554, Rv3571, etc. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.	Q7TZ95,A0A1R3Y0K2	No	intermediary metabolism and respiration			A0A1R3Y0K2				IPR001041,IPR001221,IPR001433,IPR006058,IPR008333,IPR012675,IPR017927,IPR017938	Q7TZ95					Rv1937		Rv1937			
NC_002945.3	Mycobrowser_v4	CDS	2187623	2188987	.	+	0	Mb1980	Mb1980		CONSERVED HYPOTHETICAL PROTEIN	Mb1980, -, len: 454 aa. Equivalent to Rv1945, len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(99.780% identity in 454 aa overlap). Member of Mycobacterium tuberculosis REP13E12 repeat family. Similar to several others, best with Rv1148c|Z95584|MTCI65.15 (482 aa), FASTA score: opt: 2954, E(): 0, (97.1% identity in 454 aa overlap). Contains possible helix-turn-helix motif at aa 74-95 (+2.90 SD).	Q7TZ87,A0A1R3XZS1	No	insertion seqs and phages			A0A1R3XZS1				IPR002711,IPR003615,IPR003870	Q7TZ87					Rv1945		Rv1945			
NC_002945.3	Mycobrowser_v4	CDS	2183729	2184463	.	+	0	Mb1974	Mb1974		PROBABLE OXIDOREDUCTASE	Mb1974, -, len: 244 aa. Similar to Rv1939, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 167 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to NP_302637.1|NC_002677 probable oxidoreductase from Mycobacterium leprae (162 aa) Also similar to NTAB_CHELE|P54990 nitrilotriacetate monooxygenase component from Chelatobacter heintzii (322 aa), fasta scores: opt: 269, E(): 5.3e-11, (33.1% identity in 151 aa overlap). And similar to Mycobacterium tuberculosis probable monooxygenase components Rv0246,Rv3567, and to a lesser extent, Rv3007c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (t-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (244 aa versus 171 aa).	Q7TZ93,A0A1R3Y070	No				A0A1R3Y070				IPR002563,IPR012349	Q7TZ93										
NC_002945.3	Mycobrowser_v4	CDS	2185298	2186068	.	+	0	Mb1976	Mb1976		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb1976, -, len: 256 aa. Equivalent to Rv1941, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_299015.1|NC_002488 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from Xylella fastidiosa (255 aa); NP_250340.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa); NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa) (has its N-terminus longter); P50197|LINC_PSEPA 2,5-dichloro-2,5-cyclohexadiene-1,4-dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa), FASTA scores: opt: 529, E(): 5.7e-25, (40.6% identity in 251 aa overlap); etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TZ91,A0A1R3XZV8	No	intermediary metabolism and respiration			A0A1R3XZV8				IPR002198,IPR002347,IPR016040,IPR020904	Q7TZ91					Rv1941		Rv1941			
NC_002945.3	Mycobrowser_v4	CDS	2190709	2191611	.	-	0	Mb1984c	Mb1984c		CONSERVED HYPOTHETICAL PROTEIN	Mb1984c, -, len: 300 aa. Equivalent to Rv1949c,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 300 aa overlap). Conserved hypothetical protein, partial ORF. Rv1949c and Rv1950c|MTCY09F9.14 are similar but frameshifted with respect to Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd protein (323 aa), FASTA scores: opt: 459, E(): 2.8e-16, (54.8% identity in 157 aa overlap). Cosmid sequence appears to be correct, genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97. Similar to M. tuberculosis hypothetical proteins: Rv2542, Rv2077c,Rv2797c, Rv0963c, etc.	Q7TZ83,A0A1R3Y079	No	conserved hypotheticals			A0A1R3Y079					Q7TZ83					Rv1949c		Rv1949c			
NC_002945.3	Mycobrowser_v4	CDS	2199824	2200672	.	+	0	Mb2000	Mb2000		conserved protein	Mb2000, -, len: 282 aa. Equivalent to Rv1978, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 282 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151, E(): 0.0072, (30.6% identity in 121 aa overlap).	Q7TZ68,A0A1R3Y0M7	No	conserved hypotheticals			A0A1R3Y0M7				IPR013217	Q7TZ68					Rv1978		Rv1978			
NC_002945.3	Mycobrowser_v4	CDS	2200635	2202080	.	-	0	Mb2001c	Mb2001c		POSSIBLE CONSERVED PERMEASE	Mb2001c, -, len: 481 aa. Equivalent to Rv1979c,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 480 aa overlap). Possible permease, APC family possibly involved in transport of amino acid,showing some similarity to other permeases. Also similar to MTCY39.19 from Mycobacterium tuberculosis (28.2% identity in 277 aa overlap). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.	X2BJP4,Q7TZ67,Q7TZ67	No	cell wall and cell processes			Q7TZ67					X2BJP4,Q7TZ67					Rv1979c		Rv1979c			
NC_002945.3	Mycobrowser_v4	CDS	2212797	2213132	.	-	0	Mb2013c	Mb2013c		POSSIBLE DEHYDROGENASE (FRAGMENT)	Mb2013c, -, len: 111 aa. Equivalent to Rv1990A,len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Possible dehydrogenase (fragment) (EC 1.-.-.-), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% identity in 78 aa overlap), but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa),FASTA scores: opt: 142, E(): 0.018, (54.15% identity in 48 aa overlap).	Q7TVB7,A0A1R3Y001	No	intermediary metabolism and respiration			A0A1R3Y001				IPR016040	Q7TVB7					Rv1990A		Rv1990A			
NC_002945.3	Mycobrowser_v4	CDS	2207907	2208818	.	-	0	Mb2007c	Mb2007c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LYSR-FAMILY)	Mb2007c, -, len: 303 aa. Equivalent to Rv1985c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Probable transcriptional regulatory protein, LysR family member. Similar to many regulatory proteins, especially ICIA_ECOLI|P24194 chromosome initiation inhibitor from Escherichia coli (297 aa), FASTA scores: opt: 520, E(): 1.1e-28, (35.8% identity in 285 aa overlap); and P94632|LYSG_CORGL LYSINE EXPORT REGULATOR PROTEIN (290 aa), FASTA scores: opt: 705, E(): 0, (42.7% identity in 288 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Also contains helix-turn-helix motif at aa 22-43,(+5.52 SD). BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS.	X2BJS2,P67666,P67666	No	regulatory proteins			P67666					X2BJS2,P67666					Rv1985c		Rv1985c			
NC_002945.3	Mycobrowser_v4	CDS	2208927	2209526	.	+	0	Mb2008	Mb2008		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2008, -, len: 199 aa. Equivalent to Rv1986, len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to P11667|YGGA_ECOLI hypothetical 23.2 kd protein in sbm-fba intergenic region (211 aa), FASTA scores: opt: 379, E(): 1.5e-19, (37.3% identity in 185 aa overlap); and Q11154|Rv0488 HYPOTHETICAL 20.9 KD PROTEIN from Mycobacterium tuberculosis (201 aa), FASTA scores: opt: 784, E(): 0,(63.4% identity in 186 aa overlap). BELONGS TO THE LYSE/YGGA FAMILY.	X2BJH6,P64904,P64904	No	cell wall and cell processes			P64904					X2BJH6,P64904					Rv1986		Rv1986			
NC_002945.3	Mycobrowser_v4	CDS	2211655	2212215	.	-	0	Mb2011c	Mb2011c		HYPOTHETICAL PROTEIN	Mb2011c, -, len: 186 aa. Equivalent to Rv1989c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Hypothetical unknown protein.	X2BJ76,P64908,P64908	No	conserved hypotheticals			P64908					X2BJ76,P64908					Rv1989c		Rv1989c			
NC_002945.3	Mycobrowser_v4	CDS	2212212	2212553	.	-	0	Mb2012c	Mb2012c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb2012c, -, len: 113 aa. Equivalent to Rv1990c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Probable transcriptional regulatory protein, similar to Mycobacterium tuberculosis Rv3188|AL021646|MTV014.32 (115 aa), FASTA scores: opt: 184, E(): 8.2e-07, (28.4% identity in 109 aa overlap). Contains probable helix-turn-helix motif at aa 20-44 (+4.22 SD).	X2BJS5,P64910	No	regulatory proteins			P64910					X2BJS5					Rv1990c		Rv1990c			
NC_002945.3	Mycobrowser_v4	CDS	2217920	2218873	.	+	0	Mb2019	Mb2019		universal stress protein family protein	Mb2019, -, len: 317 aa. Identical to Rv1996, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 317 aa overlap). Conserved hypothetical protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scores: opt: 775, E(): 0, (50.3% identity in 316 aa overlap); Rv2026c (294 aa) (47.9% identity in 311 aa overlap); and Rv2623,etc. Also similar to SCJ1.30c|AL109962 hypothetical protein from Streptomyces coelicolor (328 aa).	X2BJQ9,P0A5F8,P0A5F8	No				P0A5F8					X2BJQ9,P0A5F8										
NC_002945.3	Mycobrowser_v4	CDS	584526	584855	.	-	0	Mb0503c	Mb0503c		HYPOTHETICAL PROTEIN	Mb0503c, -, len: 109 aa. Equivalent to Rv0492A,len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein. GC plot suggests CDS.	Q7U1W5,A0A1R3XVI8	No	conserved hypotheticals			A0A1R3XVI8					Q7U1W5					Rv0492A		Rv0492A			
NC_002945.3	Mycobrowser_v4	CDS	2221861	2222637	.	-	0	Mb2021c	Mb2021c		conserved protein	Mb2021c, -, len: 258 aa. Equivalent to Rv1998c,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 258 aa overlap). Conserved hypothetical protein, showing some similarity with other hypothetical proteins e.g. U82823|SEU82823.03 Saccharopolyspora erythraea (266 aa), FASTA results: opt: 654, E(): 0,(43.8% identity in 249 aa overlap); and AL034446|SC1A9.07 Streptomyces coelicolor (251 aa), FASTA scores: opt: 592,E(): 1.5e-31, (43.4% identity in 251 aa overlap).	Q7TZ63,A0A1R3XZW5	No	conserved hypotheticals			A0A1R3XZW5				IPR015813	Q7TZ63					Rv1998c		Rv1998c			
NC_002945.3	Mycobrowser_v4	CDS	2222732	2224054	.	-	0	Mb2022c	Mb2022c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2022c, -, len: 440 aa. Equivalent to Rv1999c,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable conserved integral membrane protein, possibly transporter of cationic amino acid, similar to many transporters,especially amino acid transporters, e.g. CAC08265.1|AL392146 putative amino acid transporter from Streptomyces coelicolor (414 aa); P39277|YJEH_ECOLI hypothetical 44.8 kd protein from Escherichia coli (418 aa), FASTA scores, opt: 343, E(): 6.6e-15, (27.2% identity in 408 aa overlap); etc. Also similar to Rv1979c from Mycobacterium tuberculosis, FASTA score: (28.2% identity in 277 aa overlap); Rv2127, Rv0346c, Rv0522, etc. SEEMS TO BELONG TO THE APC FAMILY.	X2BJI4,P63350,P63350	No	cell wall and cell processes			P63350					X2BJI4,P63350					Rv1999c		Rv1999c			
NC_002945.3	Mycobrowser_v4	CDS	2224125	2225738	.	+	0	Mb2023	Mb2023		unknown protein	Mb2023, -, len: 537 aa. Equivalent to Rv2000, len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 537 aa overlap). Hypothetical unknown protein.	X2BJU5,P64918	No	conserved hypotheticals			P64918					X2BJU5					Rv2000		Rv2000			
NC_002945.3	Mycobrowser_v4	CDS	2249336	2254156	.	-	0	Mb2049c	Mb2049c		CONSERVED HYPOTHETICAL PROTEIN	Mb2049c, RvD1-Rv2024c, len: 1606 aa. Equivalent to Rv2024c and similar to Rv2020c, len: 515 aa and 99 aa,from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 506 aa overlap and 67.0% identity in 97 aa overlap). Rv2024c: Conserved hypothetical protein. Identical to N-terminal part of much larger hypothetical protein, RvD1-Rv2024c' (1606 aa), from Mycobacterium bovis BCG: CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably truncated. Part of RvD1 chromosomal deletion region. Also similar to hypothetical protein from Helicobacter pylori. FASTA scores: AE0005|HPAE000580_2 Helicobacter pylori (607 aa) opt: 64, E(): 0, (36.2% identity in 464 aa overlap). Rv2020c: Conserved hypothetical protein, nearly identical to C-terminal part of hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds to deletion region RvD1 so probably truncated protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa).	Q7TZ47,A0A1R3Y012	No				A0A1R3Y012				IPR001650,IPR002052,IPR002296,IPR006935,IPR011335,IPR011856,IPR014001,IPR027417	Q7TZ47										
NC_002945.3	Mycobrowser_v4	CDS	2228394	2229890	.	-	0	Mb2027c	Mb2027c		conserved protein	Mb2027c, -, len: 498 aa. Equivalent to Rv2004c,len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 498 aa overlap). Conserved hypothetical protein similar to several e.g. >pir||T36945 hypothetical protein SCJ1.12 (508 aa) - Streptomyces coelicolor >gi|5748625|emb|CAB53130.1| (AL109962). Smith-Waterman score: 7e-94, Identities = 199/468 (42%). Contains PS00017 ATP/GTP-binding site motif A.	X2BJI8,P0A5G0,P0A5G0	No	conserved hypotheticals			P0A5G0					X2BJI8,P0A5G0					Rv2004c		Rv2004c			
NC_002945.3	Mycobrowser_v4	CDS	2229912	2230799	.	-	0	Mb2028c	Mb2028c		universal stress protein family protein	Mb2028c, -, len: 295 aa. Equivalent to Rv2005c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Conserved hypothetical protein, similar to MTCY39.23c, (50.3% identity in 316 aa overlap), C-terminus shows some similarity with YXIE_BACSU P42297 hypothetical 15.9 kd protein in bglh- (148 aa), FASTA scores, opt: 124, E(): 0.038, (28.5% identity in 144 aa overlap), also similar to Rv2623 (294 aa), (52.7% identity in 296 aa overlap) and other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1996, Rv2624c, Rv2028c, Rv3134c, Rv1636. Some,possibly all, of these belong to universal stress protein family.	X2BJU8,P64922,P64922	No	virulence, detoxification, adaptation			P64922					X2BJU8,P64922					Rv2005c		Rv2005c			
NC_002945.3	Mycobrowser_v4	CDS	2245721	2246026	.	-	0	Mb2044c	Mb2044c		transcriptional regulatory protein	Mb2044c, -, len: 101 aa. Equivalent to Rv2021c,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Unknown, possible regulatory protein similar to Mycobacterium tuberculosis hypothetical protein Rv3183, MTV014.27 (EMBL; AL021646). FASTA scores; TR:E12487 74 (109 aa) opt: 214 E(): 1.2e-09,43.0% identity in 107 aa overlap. Contains probable helix-turn-helix at aa 45-66 (Score 1472, +4.20 SD)	Q7TZ52,A0A1R3XZX6	No	regulatory proteins			A0A1R3XZX6				IPR001387,IPR010982	Q7TZ52					Rv2021c		Rv2021c			
NC_002945.3	Mycobrowser_v4	CDS	2291734	2292069	.	+	0	Mb2076	Mb2076		conserved protein	Mb2076, -, len: 111 aa. Equivalent to Rv2050, len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium leprae, MLCB2052.03c (113 aa), and Streptomyces coelicolor A3(2), SC6D7.18c (124 aa). FASTA scores: Z98604|MLCB2052_3 Mycobacterium leprae cosmid B2052 (113 aa) opt: 737, E(): 0, (97.3% identity in 111 aa overlap) and (55% identity in 85 aa overlap) with emb|CAB61670.1|AL133213 hypothetical protein SC6D7.18c. TBparse score is 0.884	Q7TZ33,A0A1R3Y022	No	conserved hypotheticals	2M4V,2M6P		A0A1R3Y022				IPR025182	Q7TZ33					Rv2050		Rv2050			
NC_002945.3	Mycobrowser_v4	CDS	2235533	2236858	.	-	0	Mb2031c	Mb2031c		CONSERVED HYPOTHETICAL PROTEIN	Mb2031c, -, len: 441 aa. Equivalent to Rv2008c,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Conserved hypothetical protein. Contains PS00017 ATP/GTP-binding site motif A, PS00501 Signal peptidases I serine active site. Also contains helix-turn-helix motif at aa 258-279. Similar to several conserved hypothetical proteins e.g. NP_085874.1|14028123|dbj|BAB54715.1 hypothetical protein from Mesorhizobium loti (435 aa). Smith-Waterman score: 1e-74, Identities = 158/359 (44%)	X2BJU6,P64924,P64924	No	conserved hypotheticals			P64924					X2BJU6,P64924					Rv2008c		Rv2008c			
NC_002945.3	Mycobrowser_v4	CDS	2237770	2238201	.	-	0	Mb2034c	Mb2034c		conserved hypothetical protein, probable transcription repressor.	Mb2034c, -, len: 143 aa. Equivalent to Rv2011c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein, some similarity to putative regulatory proteins e.g. putative marR-family regulatory protein from Streptomyces coelicolor A3(2) (157 aa),emb|CAB63189.1| (AL133469) 34% identity in 110 aa overlap. Low similarity to PETP_RHOCA P31078 petp protein. Rhodobacter capsulatus (166 aa), FASTA scores, opt: 101,E(): 0 .36, (31.8% identity in 88 aa overlap)	X2BJS0,P64928	No	regulatory proteins			P64928					X2BJS0					Rv2011c		Rv2011c			
NC_002945.3	Mycobrowser_v4	CDS	2238242	2238736	.	+	0	Mb2035	Mb2035		CONSERVED HYPOTHETICAL PROTEIN	Mb2035, -, len: 164 aa. Equivalent to Rv2012, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Conserved hypothetical protein, similar to AAK04358.1|AE006263_5 hypothetical protein from Lactococcus lactis (137 aa),(48% identity in 129 aa overlap).	X2BJ94,P64930	No	conserved hypotheticals			P64930					X2BJ94					Rv2012		Rv2012			
NC_002945.3	Mycobrowser_v4	CDS	2239440	2240060	.	+	0	Mb2036	Mb2036		transposase	Mb2036, -, len: 206 aa. Similar to Rv2013, len: 159 aa, from Mycobacterium tuberculosis strain H37Rv. Possible transposase: shows similarity to N-terminal part of transposase and insertion element hypothetical proteins eg sp|Q53198|Y4UE_RHISN PUTATIVE TRANSPOSASE Y4UE (359 aa) opt: 383, E(): 1.3e-18; 35.1% identity in 225 aa overlap; sp|P 14707|YM3_STRCO MINI-CIRCLE HYPOTHETICAL 45.7 KD P (414 aa) opt: 302, E(): 4.2e-13; 33.3% identity in 207 aa overlap; and YI90_MYCPA P14322 insertion element is900 hypothetical protein (399 aa), FASTA scores, opt: 146,E(): 0.0021, (26.9% identity in 145 aa overlap). Length changed since first submission (no clear start apparent). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) at the 5' start of Mb2036,leads to a longer product with a different NH2 part compared toits homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa).	Q7TZ59,A0A1R3XZY3	No				A0A1R3XZY3				IPR002525	Q7TZ59										
NC_002945.3	Mycobrowser_v4	CDS	2322760	2323704	.	+	0	Mb2109	Mb2109		CONSERVED HYPOTHETICAL PROTEIN	Mb2109, -, len: 314 aa. Equivalent to Rv2083, len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 314 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv3898c (110 aa) and Rv3897c (210 aa)	Q7TZ23,A0A1R3Y069	No	conserved hypotheticals			A0A1R3Y069					Q7TZ23					Rv2083		Rv2083			
NC_002945.3	Mycobrowser_v4	CDS	2240014	2240604	.	+	0	Mb2037	Mb2037		transposase	Mb2037, -, len: 196 aa. Equivalent to Rv2014, len: 196 aa, from Mycobacterium tuberculosis strain H37Rv, (). Possible transposase, similar to insertion elements e.g. sp|P14707|YM3_STRCO MINI-CIRCLE HYPOT HETICAL 45.7 KD P (414 aa) opt: 249 z-score: 307.0 E(): 1.4e-09; 33.1% identity in 169 aa overlap; and YI90_MYCPA P14322 insertion element is900 hypothetical protein (399 a a),FASTA scores, opt: 242, z-score: 299.9, E(): 3.7e-10, (3 2.5% identity in 163 aa overlap); possibly made by frameshifting with respect to upstream ORF. Length changed since first submission.	Q7TZ58,A0A1R3Y237	No	insertion seqs and phages			A0A1R3Y237				IPR003346	Q7TZ58					Rv2014		Rv2014			
NC_002945.3	Mycobrowser_v4	CDS	2240732	2241988	.	-	0	Mb2038c	Mb2038c		CONSERVED HYPOTHETICAL PROTEIN	Mb2038c, -, len: 418 aa. Equivalent to Rv2015c,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 418 aa overlap). Conserved hypothetical protein. Nearly identical to Mycobacterium tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting next to ISB9, and ending in IS6110. Different N-terminus chosen and C-terminus differs as that of Rv1765c has been truncated by IS6110. Does NOT show similarities with transposases. BLAST hits with non-IS part of MTU78639. FASTA scores: Z95890|MTCY28_31 (378 aa) opt: 2417, E(): 0,(97.8% identity in 364 aa overlap).	Q7TZ57,A0A1R3Y0Q9	No	conserved hypotheticals			A0A1R3Y0Q9				IPR002711,IPR003615,IPR003870	Q7TZ57					Rv2015c		Rv2015c			
NC_002945.3	Mycobrowser_v4	CDS	2242342	2242917	.	+	0	Mb2039	Mb2039		HYPOTHETICAL PROTEIN	Mb2039, -, len: 191 aa. Equivalent to Rv2016, len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 191 aa overlap). Hypothetical protein.	Q7TZ56,A0A1R3Y002	No	conserved hypotheticals			A0A1R3Y002					Q7TZ56					Rv2016		Rv2016			
NC_002945.3	Mycobrowser_v4	CDS	2316945	2317259	.	+	0	Mb2104	Mb2104		conserved hypothetical protein	Mb2104, -, len: 104 aa. Equivalent to Rv2078, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 104 aa overlap). Unknown	X2BJE3,P59982	No	conserved hypotheticals			P59982					X2BJE3					Rv2078		Rv2078			
NC_002945.3	Mycobrowser_v4	CDS	2242914	2243954	.	+	0	Mb2040	Mb2040		transcriptional regulatory protein	Mb2040, -, len: 346 aa. Equivalent to Rv2017, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 346 aa overlap). Hypothetical regulatory protein, shows similarity at N-terminal end to several transcriptional regulators e.g. Bacillus subtilis BSUB0012_44 (108 aa). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature in C-terminal half, may be fortuitous. FASTA scores: Z99115|BSUB0012_44 Bacillus subtilis (108 aa) opt: 154,E(): 0.0012; 35.5% identity in 62 aa overlap. Contains probable helix-turn-helix motif at aa 18-39 (Score 2243,+6.83 SD)	Q7VET2,A0A1R3Y0C4	No	regulatory proteins			A0A1R3Y0C4				IPR001387,IPR010359,IPR010982	Q7VET2					Rv2017		Rv2017			
NC_002945.3	Mycobrowser_v4	CDS	2244196	2244915	.	+	0	Mb2041	Mb2041		conserved protein	Mb2041, -, len: 239 aa. Equivalent to Rv2018, len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 239 aa overlap). Conserved hypothetical protein, similar to Rv2308|MTCY339.01c (238 aa). FASTA scores: Z77163|MTCY339_1 Mycobacterium tuberculosis cosmid (238 aa) opt: 142, E(): 0.029; (24.8% identity in 250 aa overlap). Contains probable helix-turn-helix motif at aa 215-236 (Score 1175, +3.19 SD).	Q7TZ55,A0A1R3XZX8	No	conserved hypotheticals			A0A1R3XZX8				IPR007367,IPR009057,IPR011991,IPR017277	Q7TZ55					Rv2018		Rv2018			
NC_002945.3	Mycobrowser_v4	CDS	2246035	2246640	.	-	0	Mb2045c	Mb2045c		conserved protein	Mb2045c, -, len: 201 aa. Equivalent to Rv2022c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv3182, MTV014.26 (EMBL:AL 021646). FASTA scores; TR:E1248773 (114 aa) opt: 335, E(): 3e-22, 53.8% identity in 106 aa overlap and to hypothetical proteins from Yersinia pestis (115 aa) e.g. emb|CAB53172.1| (AL109969), 41% identity in 108 aa overlap.	Q7TZ51,A0A1R3Y021	No	conserved hypotheticals			A0A1R3Y021				IPR009241	Q7TZ51					Rv2022c		Rv2022c			
NC_002945.3	Mycobrowser_v4	CDS	2254664	2255662	.	-	0	Mb2050c	Mb2050c		conserved membrane protein	Mb2050c, -, len: 332 aa. Equivalent to Rv2025c,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 332 aa overlap). Possible conserved transmembrane protein, CDF family possibly involved in transport of metal ions, similar to several hypothetical bacterial proteins e. g. Methanobacterium thermoautotrophicum AE000941_1 (298 aa; described as cation efflux system protein) and Archaeoglob us fulgidus AE001111_5 (384 aa). FASTA scores: AE000941_1 M ethanobacterium thermoautotrophicum (298 aa) opt: 452 E(): 3.3e-24; 30.8% identity in 266 aa overlap and AE001111_5 Archaeoglobus fulgidus section 16 (384 aa) opt: 371 E(): 1.7e-18; 27.7% identity in 267 aa overlap. TBparse score is 0.897	Q7TZ46,A0A1R3Y0D1	No	cell wall and cell processes			A0A1R3Y0D1				IPR002524,IPR027469,IPR027470	Q7TZ46					Rv2025c		Rv2025c			
NC_002945.3	Mycobrowser_v4	CDS	2255777	2256661	.	-	0	Mb2051c	Mb2051c		universal stress protein family protein	Mb2051c, -, len: 294 aa. Equivalent to Rv2026c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Conserved hypothetical protein, very similar to Mycobacterium tuberculosis hypothetical proteins Rv2005c, Rv2623,Rv1996, Rv2624c, Rv2028c, Rv3134c, Rv1636. Some, possibly all, of these belong to universal stress protein family.	Q7TZ45,A0A1R3XZY6	No	virulence, detoxification, adaptation			A0A1R3XZY6				IPR006015,IPR006016,IPR014729	Q7TZ45					Rv2026c		Rv2026c			
NC_002945.3	Mycobrowser_v4	CDS	2258483	2259322	.	-	0	Mb2053c	Mb2053c		universal stress protein family protein	Mb2053c, -, len: 279 aa. Equivalent to Rv2028c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Conserved hypothetical protein, highly similar to Mycobacterium tuberculosis proteins Rv2005c, Rv2623, Rv1996, Rv2624c,Rv3134c, Rv1636. Some, possibly all, of these belong to universal stress protein family. Rv2624c|MTCY01A10.08 (272 aa) and Rv3134c|MTCY03A2.24 (268 aa). FASTA scores: Z95387|MTCY1A10_8 (272 aa) opt: 563, E(): 2.5e-31, (36.8% identity in 266 aa overlap) and Z83867|MTCY3A2_24 (268 aa) opt: 562, E(): 2.9e-31, (40.7% identity in 273 aa overlap).	Q7TZ44,A0A1R3Y020	No	virulence, detoxification, adaptation			A0A1R3Y020				IPR006015,IPR006016,IPR014729	Q7TZ44					Rv2028c		Rv2028c			
NC_002945.3	Mycobrowser_v4	CDS	2260355	2260594	.	-	0	Mb2055c	Mb2055c		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb2055c, -, len: 79 aa. Equivalent to 3' end of Rv2030c, len: 681 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 79 aa overlap). Conserved hypothetical protein that corresponds to products of two adjacent ORF's described previously MSGTUBDWN_4 (390 aa) and MSGTUBDWN_1 (385 aa). Also similar to C-terminal two-thirds of Mycobacterium tuberculosis protein Rv2143 (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and Mycobacterium leprae protein U650s MLU15184_16 (258 aa). FASTA scores: M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; 97.7% identity in 385 aa overlap and M93129|MSGTUBDWN_1 (385 aa) opt: 1983 E(): 0; 99.0% identity in 309 aa overlap. Z95388| MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 % identity in 226 aa overlap. U15184|MLU15184_16 (258 aa) opt: 549 E(): 9.8e-29; 43.8% identity in 219 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c.	Q7TZ42,A0A1R3Y033	No				A0A1R3Y033				IPR007815	Q7TZ42										
NC_002945.3	Mycobrowser_v4	CDS	2324512	2324844	.	+	0	Mb2111	Mb2111		HYPOTHETICAL PROTEIN	Mb2111, -, len: 110 aa. Similar to 3' end of Rv2084, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, (97.0% identity in 100 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis stain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts,Mb2110 and Mb2111.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2260579	2262399	.	-	0	Mb2056c	Mb2056c		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb2056c, -, len: 606 aa. Equivalent to 5' end of Rv2030c, len: 681 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 587 aa overlap). Conserved hypothetical protein that corresponds to products of two adjacent ORF's described previously MSGTUBDWN_4 (390 aa) and MSGTUBDWN_1 (385 aa). Also similar to C-terminal two-thirds of Mycobacterium tuberculosis protein Rv2143 (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and Mycobacterium leprae protein U650s MLU15184_16 (258 aa). FASTA scores: M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; 97.7% identity in 385 aa overlap and M93129|MSGTUBDWN_1 (385 aa) opt: 1983 E(): 0; 99.0% identity in 309 aa overlap. Z95388| MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 % identity in 226 aa overlap. U15184|MLU15184_16 (258 aa) opt: 549 E(): 9.8e-29; 43.8% identity in 219 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c.	Q7TZ41,A0A1R3Y005	No				A0A1R3Y005				IPR000836,IPR007815	Q7TZ41										
NC_002945.3	Mycobrowser_v4	CDS	2266660	2267634	.	-	0	Mb2063c	Mb2063c		conserved transmembrane protein	Mb2063c, -, len: 324 aa. Equivalent to Rv2037c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 324 aa overlap). Possible conserved transmembrane protein, similar to hypothetical proteins from Mycobacterium leprae MLCB2052.31 (329 aa) and Bacillus subtilis P54513|YQHO_BACSU (291 aa). FASTA scores: Z98604|MLCB2052_1 6 Mycobacterium leprae cosmid B205 (329 aa) opt: 1764, E(): 0; 80.5% identity in 323 aa overlap and sp|P54513|YQHO_BACSU HYPOTHETICAL 32.9 KD PROTEIN IN G (291 aa ) opt: 328, E(): 8.8e-14; 36.6% identity in 306 aa overlap. TBparse score is 0.919	Q7TZ37,A0A1R3Y031	No	cell wall and cell processes			A0A1R3Y031				IPR002641,IPR016035	Q7TZ37					Rv2037c		Rv2037c			
NC_002945.3	Mycobrowser_v4	CDS	2264153	2264995	.	-	0	Mb2059c	Mb2059c		CONSERVED HYPOTHETICAL PROTEIN	Mb2059c, -, len: 280 aa. Equivalent to Rv2033c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, similar to hypothetical protein SCC77.24 (274 aa) from Streptomyces coelicolor A3(2) CAB66235.1|AL13650) (50% identity in 261 aa overlap).	Q7TZ40,A0A1R3Y017	No	conserved hypotheticals			A0A1R3Y017				IPR021447	Q7TZ40					Rv2033c		Rv2033c			
NC_002945.3	Mycobrowser_v4	CDS	2266012	2266653	.	+	0	Mb2062	Mb2062		CONSERVED HYPOTHETICAL PROTEIN	Mb2062, -, len: 213 aa. Equivalent to Rv2036, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 213 aa overlap). Conserved hypothetical protein; slight similarity to Streptomyces lincolnensis protein involved in lincomycin production Q54375 (238 aa). FASTA scores: sptr|Q54375|Q54375 (78-11) LINCOMYCIN PRODUCTION GENES (238 aa) opt: 119, E(): 0.97; 31.3% identity in 99 aa overlap. TBparse score is 0.934	Q7TZ38,A0A1R3Y046	No	conserved hypotheticals			A0A1R3Y046				IPR010872,IPR017517,IPR024344,IPR027369	Q7TZ38					Rv2036		Rv2036			
NC_002945.3	Mycobrowser_v4	CDS	2466141	2466563	.	-	0	Mb2243c	Mb2243c		probable conserved membrane protein	Mb2243c, -, len: 140 aa. Equivalent to Rv2219A,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable membrane protein, similar to SC3H12.05c|AL355740_5 possible integral membrane protein from Streptomyces coelicolor (155 aa), FASTA scores: opt: 327, E(): 7.5e-14, (46.6% identity in 133 aa overlap), also linked to glnA.	Q7TYX1,A0A1R3Y0I9	No	cell wall and cell processes			A0A1R3Y0I9				IPR010432,IPR016795	Q7TYX1					Rv2219A		Rv2219A			
NC_002945.3	Mycobrowser_v4	CDS	2267636	2268709	.	-	0	Mb2064c	Mb2064c		Probable sugar-transport ATP-binding protein ABC transporter	Mb2064c, -, len: 357 aa. Equivalent to Rv2038c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). Probable sugar-transport ATP-binding protein ABC transporter (see citation below), equivalent to MLCB2052.30|Z98604|MLCB2052_15 from Mycobacterium leprae (356 aa), FASTA scores: opt: 1866, E(): 0, (79.7% identity in 355 aa overlap). Also similar to multiple sugar import proteins e.g. Y08921|SRMSIK_1 msiK protein from Streptomyces reticuli (377 aa), FASTA scores: opt: 1336,E(): 0, (62.6% identity in 377 aa overlap); etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Rv2832c, Rv1238, Rv2397c, Rv3758c. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7VES8,A0A1R3Y000	No	cell wall and cell processes			A0A1R3Y000				IPR003439,IPR003593,IPR008995,IPR012340,IPR013611,IPR017871,IPR027417	Q7VES8					Rv2038c		Rv2038c			
NC_002945.3	Mycobrowser_v4	CDS	2268712	2269554	.	-	0	Mb2065c	Mb2065c		Probable sugar-transport integral membrane protein ABC transporter	Mb2065c, -, len: 280 aa. Equivalent to Rv2039c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 280 aa overlap). Probable sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to MLCB2052.29|Z98604|MLCB2052_14 from Mycobacterium leprae (283 aa), FASTA scores: opt: 1593, E(): 0, (79.2% identity in 283 aa overlap). Also similar to maltose and lactose transport proteins e.g. X66092|CPMALGHOM_1 from C. perfringens (275 aa), FASTA scores: opt: 695, E(): 0,(41.2% identity in 228 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Also contains possible helix-turn-helix motif at aa 171-192, although this is probably fortuitous.	Q7VES7,A0A1R3Y041	No	cell wall and cell processes			A0A1R3Y041				IPR000515	Q7VES7					Rv2039c		Rv2039c			
NC_002945.3	Mycobrowser_v4	CDS	2269541	2270443	.	-	0	Mb2066c	Mb2066c		Probable sugar-transport integral membrane protein ABC transporter	Mb2066c, -, len: 300 aa. Equivalent to Rv2040c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to MLCB2052.28|Z98604|MLCB2052_13 from Mycobacterium leprae (319 aa), FASTA scores: opt: 1606, E(): 0, (81.6% identity in 293 aa overlap). Also similar to many diverse sugar transport proteins.	Q7VES6,A0A1R3Y015	No	cell wall and cell processes			A0A1R3Y015				IPR000515	Q7VES6					Rv2040c		Rv2040c			
NC_002945.3	Mycobrowser_v4	CDS	2297038	2297751	.	+	0	Mb2080	Mb2080		conserved protein	Mb2080, -, len: 237 aa. Equivalent to Rv2054, len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Conserved hypothetical protein, some similarity to various carboxymethylenebutenolidases e.g. sp|O67988|CLCD_RHOOP CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (DLH) >gi|2935034|gb|AAC38252.1| (AF003948) dienelactone hydrolase [Rhodococcus opacus] Smith-Waterman scores: Length = 252, Expect = 4e-08 Identities = 62/217 (28%). Also similar to Rv2765.	Q7TZ31,A0A1R3Y0F5	No	conserved hypotheticals			A0A1R3Y0F5				IPR002925	Q7TZ31					Rv2054		Rv2054			
NC_002945.3	Mycobrowser_v4	CDS	2270440	2271759	.	-	0	Mb2067c	Mb2067c		Probable sugar-binding lipoprotein	Mb2067c, -, len: 439 aa. Equivalent to Rv2041c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Probable sugar-binding lipoprotein component of sugar transport system,equivalent to Z98604|MLCB2052_1|MLCB2052.27 from Mycobacterium leprae (445 aa), FASTA scores: opt: 2324,E(): 0, (77.4% identity in 446 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7VES5,A0A1R3Y269	No	cell wall and cell processes			A0A1R3Y269				IPR006059,IPR006311	Q7VES5					Rv2041c		Rv2041c			
NC_002945.3	Mycobrowser_v4	CDS	2271797	2272594	.	-	0	Mb2068c	Mb2068c		conserved protein	Mb2068c, -, len: 265 aa. Equivalent to Rv2042c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Conserved hypothetical protein,similar in N-terminal part to hypothetical proteins MLCB2052.24 (95 aa) and Rv0760c|MTCY369.05 (139 aa). FASTA scores: Z98604|MLCB2052_9 Mycobacterium leprae cosmid B2052 (95 aa) opt: 269, E(): 2.9e-12, (55.4% identity in 92 aa overlap) and Z80226|MTCY369_5 Mycobacterium tuberculosis cosmid (139 aa) opt: 150, E(): 0.001, (28.7% identity in 136 aa overlap).	Q7TZ36,A0A1R3Y0U1	No	conserved hypotheticals			A0A1R3Y0U1				IPR002075	Q7TZ36					Rv2042c		Rv2042c			
NC_002945.3	Mycobrowser_v4	CDS	2273195	2273512	.	-	0	Mb2070c	Mb2070c		CONSERVED HYPOTHETICAL PROTEIN	Mb2070c, -, len: 105 aa. Equivalent to Rv2044c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical protein PA3386 (121 aa) from Pseudomonas aeruginosa |E83221 conserved hypothetical protein PA3386 [imported] -Pseudomonas aeruginosa (strain PAO1) 9949522|gb|AAG06774.1|AE004760_2 (AE004760). (46% identity in 92 aa overlap).	Q7TZ35,A0A1R3Y0F0	No	conserved hypotheticals			A0A1R3Y0F0				IPR021218	Q7TZ35					Rv2044c		Rv2044c			
NC_002945.3	Mycobrowser_v4	CDS	2275875	2278439	.	-	0	Mb2073c	Mb2073c		CONSERVED HYPOTHETICAL PROTEIN	Mb2073c, -, len: 854 aa. Equivalent to Rv2047c,len: 854 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 854 aa overlap). Conserved hypothetical protein, similar to hypothetical protein from Mycobacterium tuberculosis Rv1868|MTCY359.05c (699 aa) and three possible pseudogene fragments from Mycobacterium leprae MLCB2052.16 (251 aa), MLCB2052.17 (120 aa),MLCB2052.18 (257 aa). FASTA scores: gp|Z98604|MLCB2052_7 (257 aa) opt: 1248, E(): 0, (78.6% identity in 248 aa overlap); and Z98604|MLCB2052_5 (251 aa) opt: 674, E(): 0,(50.0% identity in 250 aa overlap); and Z98604|MLCB2052_6 (120 aa) opt: 608 E() : 3.6e-30, (84.0% identity in 106 aa overlap); and Rv1868 Z83859|MTCY359_5 (699 aa) opt: 521 E(): 3e-24; (33.0% identity in 730 aa overlap).	X2BJW9,P65685,P65685	No	conserved hypotheticals			P65685					X2BJW9,P65685					Rv2047c		Rv2047c			
NC_002945.3	Mycobrowser_v4	CDS	2291206	2291430	.	-	0	Mb2075c	Mb2075c		conserved hypothetical protein	Mb2075c, -, len: 74 aa. Equivalent to Rv2049c, len: 74 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 74 aa overlap). Hypothetical protein.	Q7TZ34,A0A1R3Y049	No	conserved hypotheticals			A0A1R3Y049					Q7TZ34					Rv2049c		Rv2049c			
NC_002945.3	Mycobrowser_v4	CDS	2294826	2296430	.	-	0	Mb2078c	Mb2078c		conserved protein	Mb2078c, -, len: 534 aa. Equivalent to Rv2052c,len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 534 aa overlap). Conserved hypothetical protein, very similar to hypothetical protein SC6D7.15 (536 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores >emb|CAB61667.1| (AL133213) hypothetical protein SC6D7.15 [Streptomyces coelicolor A3(2)] Expect = e-113 Identities = 247/533 (46%)	Q7TZ32,A0A1R3Y0U8	No	conserved hypotheticals			A0A1R3Y0U8				IPR011059,IPR013108	Q7TZ32					Rv2052c		Rv2052c			
NC_002945.3	Mycobrowser_v4	CDS	2299087	2300622	.	+	0	Mb2085	Mb2085		CONSERVED HYPOTHETICAL PROTEIN	Mb2085, -, len: 511 aa. Equivalent to Rv2059, len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Conserved hypothetical protein. Some similarity to EWLA protein gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k (304 aa), FASTA score, opt: 287 E(): 6.9e-09; 27.2% identity in 228 aa overlap. There appears to be a frameshift in this ORF around position 3315980 that causes an overlap with next ORF. C-terminal end of protein may be wrong. No error can be found to account for this.	Q7TZ30,A0A1R3Y059	No	conserved hypotheticals			A0A1R3Y059				IPR006127	Q7TZ30					Rv2059		Rv2059			
NC_002945.3	Mycobrowser_v4	CDS	2300192	2300593	.	+	0	Mb2086	Mb2086		Possible conserved integral membrane protein	Mb2086, -, len: 133 aa. Equivalent to Rv2060, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 133 aa overlap). Possible conserved integral membrane protein smaller than but similar to several hypothetical bacterial proteins e.g. >emb|CAC29843.1| (AL583918) putative ABC-transporter transmembrane protein [Mycobacterium leprae] Length = 286 and P44691|YEBI_HAEIN (261 aa). FASTA scores: P44691|YEBI_HAEIN HYPOTHETICAL PROTEIN HI0407 (261 aa) opt: 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap. Maybe frameshift upstream at position 3315980 but no error can be found to account for this.	Q7VER9,UPI00000C1599	No	cell wall and cell processes			UPI00000C1599				IPR001626	Q7VER9					Rv2060		Rv2060			
NC_002945.3	Mycobrowser_v4	CDS	2300594	2300998	.	-	0	Mb2087c	Mb2087c		conserved protein	Mb2087c, -, len: 134 aa. Equivalent to Rv2061c,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Conserved hypothetical protein. Similar to conserved hypothetical proteins from Mycobacterium leprae (128 aa) and Streptomyces coelicolor (153 aa). Smith-Waterman scores: >emb|CAC30396.1| (AL583922) [Mycobacterium leprae], Expect = 7e-47, Identities = 92/131 (70%); >emb|CAC14932.1| (AL449216) [Streptomyces coelicolor], Expect = 6e-19 Identities = 48/124 (38%).	Q7TZ29,A0A1R3Y034	No	conserved hypotheticals			A0A1R3Y034				IPR011576,IPR012349,IPR019965	Q7TZ29					Rv2061c		Rv2061c			
NC_002945.3	Mycobrowser_v4	CDS	2308560	2309783	.	-	0	Mb2093c	Mb2093c		conserved protein	Mb2093c, -, len: 407 aa. Equivalent to Rv2067c,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Conserved hypothetical protein, some similarity to YAT1_SYNP6 P08442 atp synthase subunits region ORF 1. (417 aa), FASTA scores, opt: 373, E(): 4.9e-18, (27.7% identity in 358 aa overlap)	X2BJY9,P0A5G2	No	conserved hypotheticals			P0A5G2					X2BJY9					Rv2067c		Rv2067c			
NC_002945.3	Mycobrowser_v4	CDS	2325894	2326124	.	+	0	Mb2114	Mb2114		CONSERVED HYPOTHETICAL PROTEIN	Mb2114, -, len: 76 aa. Equivalent to Rv2087, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 76 aa overlap). Conserved hypothetical protein, with low similarity to transposases; ORFs Rv2085,Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-45 aa).	Q7TZ21,A0A1R3Y063	No	insertion seqs and phages			A0A1R3Y063					Q7TZ21					Rv2087		Rv2087			
NC_002945.3	Mycobrowser_v4	CDS	2359670	2360152	.	-	0	Mb2144c	Mb2144c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2144c, -, len: 160 aa. Equivalent to Rv2120c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Probable conserved integral membrane protein, similar to hypothetical protein from Mesorhizobium loti (153 aa). Smith-Waterman scores: NP_104030.1 hypothetical protein [Mesorhizobium loti] >gi|14023209|dbj|BAB49816.1| (AP003000) Identities = 50/135 (37%).	Q7TZ06,A0A1R3Y094	No	cell wall and cell processes			A0A1R3Y094					Q7TZ06					Rv2120c		Rv2120c			
NC_002945.3	Mycobrowser_v4	CDS	2313977	2314765	.	-	0	Mb2100c	Mb2100c		Possible hypothetical exported or envelope protein	Mb2100c, -, len: 262 aa. Equivalent to 5' end of Rv2075c, len: 487 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 259 aa overlap). Possibly exported or envelope protein; has potential signal peptide at N-terminus and hydrophobic stretch around residue 430. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 2029 bp deletion (RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7VER2,A0A1R3Y0I2	No				A0A1R3Y0I2				IPR000909,IPR017946	Q7VER2										
NC_002945.3	Mycobrowser_v4	CDS	2316181	2316480	.	-	0	Mb2103c	Mb2103c		CONSERVED HYPOTHETICAL PROTEIN	Mb2103c, -, len: 99 aa. Equivalent to Rv2077A, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein, similar to P95263|Rv1951c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA scores: opt: 271, E(): 1.5e-11, (51.04% identity in 97 aa overlap); and some similarity with P95012|Rv2541 HYPOTHETICAL ALANINE RICH PROTEIN from Mycobacterium tuberculosis (135 aa), FASTA scores: opt: 140, E(): 0.014,(32.95% identity in 88 aa overlap).	Q7TZ27,A0A1R3Y068	No	conserved hypotheticals			A0A1R3Y068					Q7TZ27					Rv2077A		Rv2077A			
NC_002945.3	Mycobrowser_v4	CDS	2330401	2331135	.	-	0	Mb2118c	Mb2118c		Probable membrane protein	Mb2118c, -, len: 244 aa. Equivalent to Rv2091c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable membrane protein; contains potential transmembrane region. Repetitive ORF.	X2BK18,P64940,P64940	No	cell wall and cell processes			P64940					X2BK18,P64940					Rv2091c		Rv2091c			
NC_002945.3	Mycobrowser_v4	CDS	2317241	2319211	.	+	0	Mb2105	Mb2105		CONSERVED HYPOTHETICAL PROTEIN	Mb2105, -, len: 656 aa. Equivalent to Rv2079, len: 656 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 656 aa overlap). Conserved hypothetical protein; part of Mycobacterium tuberculosis protein family with Rv2542, Rv2077c, Rv2797c, Rv0963c, Rv1949c. Contains PS00120 Lipases, serine active site	Q7TZ26,A0A1R3Y081	No	conserved hypotheticals			A0A1R3Y081				IPR010427	Q7TZ26					Rv2079		Rv2079			
NC_002945.3	Mycobrowser_v4	CDS	2319951	2320394	.	-	0	Mb2107c	Mb2107c		conserved transmembrane protein	Mb2107c, -, len: 147 aa. Equivalent to Rv2081c,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 147 aa overlap). Possible transmembrane unknown protein. Hydrophobic stretch from aa 32-54. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp insertion (*-ggg) leads to a slightly longer product compared t its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa).	Q7TZ25,A0A1R3Y2B4	No	cell wall and cell processes			A0A1R3Y2B4					Q7TZ25					Rv2081c		Rv2081c			
NC_002945.3	Mycobrowser_v4	CDS	2320598	2322763	.	+	0	Mb2108	Mb2108		CONSERVED HYPOTHETICAL PROTEIN	Mb2108, -, len: 721 aa. Equivalent to Rv2082, len: 721 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 721 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0029, and to Rv3899c and Rv3900c which may be frameshifted.	Q7TZ24,A0A1R3Y0X4	No	conserved hypotheticals			A0A1R3Y0X4					Q7TZ24					Rv2082		Rv2082			
NC_002945.3	Mycobrowser_v4	CDS	2323697	2324692	.	+	0	Mb2110	Mb2110		HYPOTHETICAL PROTEIN	Mb2110, -, len: 331 aa. Similar to 5' end of Rv2084, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 284 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts,Mb2110 and Mb2111.	Q7TZ22,A0A1R3Y0J2	No				A0A1R3Y0J2					Q7TZ22										
NC_002945.3	Mycobrowser_v4	CDS	2324927	2325232	.	+	0	Mb2112	Mb2112		CONSERVED HYPOTHETICAL PROTEIN	Mb2112, -, len: 101 aa. Equivalent to Rv2085, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Conserved hypothetical protein, similar to YI32_MYCTU P19772 insertion element IS986 hypothetical 6.6 kda protein (59 aa), FASTA scores, opt: 119, E(): 0.002 9, (36.4% identity in 55 aa overlap); ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Contains possible helix-turn-helix motif at aa 33 to 54,(+3.11 SD).	X2BJZ0,P64936	No	insertion seqs and phages			P64936					X2BJZ0					Rv2085		Rv2085			
NC_002945.3	Mycobrowser_v4	CDS	2325211	2325816	.	+	0	Mb2113	Mb2113		CONSERVED HYPOTHETICAL PROTEIN	Mb2113, -, len: 201 aa. Equivalent to Rv2086, len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Conserved hypothetical protein: low similarity to transposases; ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-16 aa).	X2BK12,P64938	No	insertion seqs and phages			P64938					X2BK12					Rv2086		Rv2086			
NC_002945.3	Mycobrowser_v4	CDS	2366691	2367569	.	+	0	Mb2149	Mb2149		CONSERVED HYPOTHETICAL PROTEIN	Mb2149, -, len: 292 aa. Equivalent to Rv2125, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 292 aa overlap). Conserved hypothetical protein. Corresponds to Mycobacterium leprae hypothetical protein e.g. TR:Q49797 B2126_F1_36 (317 aa), FASTA scores; opt: 1648, E(): 0, 84.1% identity in 290 aa overlap. Very similar to Mycobacterium tuberculosis hypothetical protein Rv2714	Q7TZ05,A0A1R3Y0D5	No	conserved hypotheticals			A0A1R3Y0D5				IPR008492,IPR019151	Q7TZ05					Rv2125		Rv2125			
NC_002945.3	Mycobrowser_v4	CDS	2329273	2330397	.	+	0	Mb2117	Mb2117		probable 5'-3' exonuclease	Mb2117, -, len: 374 aa. Equivalent to Rv2090, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(94.7% identity in 393 aa overlap). Probable 5'-3' exonuclease, similar to exonuclease part of DNA polymerase, e.g. DPO1_MYCTU Q07700 DNA polymerase I (EC 2.7.7.7) (pol i) (904 aa), FASTA scores, opt: 461, E(): 1.2e-17, (38.7% identity in 292 aa overlap). BELONGS TO FAMILY A OF DNA POLYMERASES. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 57 bp in-frame deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (374 aa versus 393 aa).	Q7VER0,A0A1R3Y2B9	No	information pathways			A0A1R3Y2B9				IPR002421,IPR003583,IPR008918,IPR020045,IPR020046	Q7VER0					Rv2090		Rv2090			
NC_002945.3	Mycobrowser_v4	CDS	2340230	2341882	.	+	0	Mb2126	Mb2126		CONSERVED HYPOTHETICAL PROTEIN	Mb2126, -, len: 550 aa. Equivalent to Rv2100, len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 550 aa overlap). Conserved hypothetical protein. Member of Mycobacterium tuberculosis 13E12 repeat family with Rv1148c, Rv1945, Rv3467, Rv0094c,Rv1128c, Rv1587c, Rv1702c, Rv3466, Rv1588c.	X2BJP9,P64946	No	insertion seqs and phages			P64946					X2BJP9					Rv2100		Rv2100			
NC_002945.3	Mycobrowser_v4	CDS	2354259	2354882	.	+	0	Mb2138	Mb2138		conserved protein	Mb2138, -, len: 207 aa. Equivalent to Rv2114, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Unknown	Q7TZ10,A0A1R3Y103	No	conserved hypotheticals			A0A1R3Y103				IPR016792	Q7TZ10					Rv2114		Rv2114			
NC_002945.3	Mycobrowser_v4	CDS	2383491	2384549	.	+	0	Mb2167	Mb2167		CONSERVED HYPOTHETICAL PROTEIN	Mb2167, -, len: 352 aa. Equivalent to Rv2143, len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein, strongly similar to two hypothetical mycobacterial proteins Rv2030c 2.1e-50 and Rv0571c from position 120 (Q50819; Q50111). FASTA best: Q50819 opt: 882, E() 0; (61.1% identity in 226 aa overlap). Also similar to AL021942|MTV039_9 (443 aa), FASTA scores: opt: 592, E(): 5e-30; 46.9% identity in 224 aa overlap	Q7TYZ6,A0A1R3Y135	No	conserved hypotheticals			A0A1R3Y135				IPR000836	Q7TYZ6					Rv2143		Rv2143			
NC_002945.3	Mycobrowser_v4	CDS	2556823	2557014	.	-	0	Mb2331c	Mb2331c		HYPOTHETICAL GLYCINE RICH PROTEIN	Mb2331c, -, len: 63 aa. Equivalent to Rv2307A, len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Hypothetical unknown protein.	Q7TYV1,A0A1R3Y0S7	No	conserved hypotheticals			A0A1R3Y0S7					Q7TYV1					Rv2307A		Rv2307A			
NC_002945.3	Mycobrowser_v4	CDS	2345115	2345948	.	+	0	Mb2128	Mb2128		CONSERVED HYPOTHETICAL PROTEIN	Mb2128, -, len: 277 aa. Equivalent to hypothetical protein MT2162 from Mycobacterium tuberculosis strain CDC1551 (100% identity with 277 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al.,2013). Mb---- transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BK29,A0A1R3Y0Z5	No				A0A1R3Y0Z5					X2BK29										
NC_002945.3	Mycobrowser_v4	CDS	2353055	2354248	.	+	0	Mb2137	Mb2137		Probable integral membrane protein	Mb2137, -, len: 397 aa. Equivalent to Rv2113, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 397 aa overlap). Probable integral membrane protein.	Q7VEQ7,A0A1R3Y2C2	No	cell wall and cell processes			A0A1R3Y2C2					Q7VEQ7					Rv2113		Rv2113			
NC_002945.3	Mycobrowser_v4	CDS	2384679	2385035	.	-	0	Mb2168c	Mb2168c		Probable transmembrane protein	Mb2168c, -, len: 118 aa. Equivalent to Rv2144c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Probable transmembrane protein.	Q7VEQ0,A0A1R3Y0F4	No	cell wall and cell processes			A0A1R3Y0F4					Q7VEQ0					Rv2144c		Rv2144c			
NC_002945.3	Mycobrowser_v4	CDS	2357573	2357866	.	+	0	Mb2141	Mb2141		CONSERVED HYPOTHETICAL PROTEIN	Mb2141, -, len: 97 aa. Equivalent to Rv2117, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein. Similar to hypothetical proteins from Mycobacterium leprae TR:Q49798 U2126J (97 aa), FASTA scores; opt: 554, E(): 0, 85.6% identity in 97 aa overlap,and Bacillus subtilis YLXP_BACSU P32730 hypothetical 10.7 kd protein (92 aa), FASTA scores; opt: 173, E(): 1.4e-11,34.1% identity in 82 aa overlap	Q7TZ09,A0A1R3Y074	No	conserved hypotheticals			A0A1R3Y074				IPR007546	Q7TZ09					Rv2117		Rv2117			
NC_002945.3	Mycobrowser_v4	CDS	2357895	2358737	.	-	0	Mb2142c	Mb2142c		rna methyltransferase	Mb2142c, -, len: 280 aa. Equivalent to Rv2118c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Possible S-adenosyl-l-methionine-dependent RNA methyltransferase (EC 2.1.1.-) (see citation below); corresponds to Mycobacterium leprae B2126_C1_165, similar to hypothetical proteins from several organisms e.g. Y134_METJA Q57598 hypothetical protein mj0134 (282 aa), FASTA scores; opt: 256, E(): 1e-13, FASTA scores; 30.2% identity in 285 aa overlap. The larger catalytic C-terminal domain binds the cofactor S-adenosyl-l-methionine (AdoMet) and is involved in the transfer of methyl group from AdoMet to the substrate.	Q7TZ08,A0A1R3Y0B7	No	intermediary metabolism and respiration			A0A1R3Y0B7				IPR014816	Q7TZ08					Rv2118c		Rv2118c			
NC_002945.3	Mycobrowser_v4	CDS	2358811	2359647	.	+	0	Mb2143	Mb2143		CONSERVED HYPOTHETICAL PROTEIN	Mb2143, -, len: 278 aa. Equivalent to Rv2119, len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium leprae hypothetical protein TR:Q49799 U2126V (212 aa), FASTA scores; opt: 1153, E(): 0, 83.6% identity in 195 aa overlap. Orthologs present in Rhodococcus erythropolis (gb|AAC68687.1|(AF088800) and Streptomyces emb|CAB59506.1|(AL132648)	Q7TZ07,A0A1R3Y0B1	No	conserved hypotheticals			A0A1R3Y0B1				IPR011335	Q7TZ07					Rv2119		Rv2119			
NC_002945.3	Mycobrowser_v4	CDS	2524691	2525059	.	+	0	Mb2295	Mb2295		probable conserved transmembrane protein	Mb2295, -, len: 122 aa. Equivalent to Rv2272, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable conserved transmembrane PROTEIN, similar to YIDH_ECOLI P31445 hypothetical 12.8 kd protein (115 aa), FASTA scores, opt: 291, E(): 2.9e-14, (45.6% identity in 103 aa overlap),similar to MTCY339.37c, (35.0% identity in 100 aa overlap).	X2BJS6,P64970,P64970	No	cell wall and cell processes			P64970					X2BJS6,P64970					Rv2272		Rv2272			
NC_002945.3	Mycobrowser_v4	CDS	2557623	2557805	.	-	0	Mb2333c	Mb2333c		HYPOTHETICAL PROTEIN	Mb2333c, -, len: 60 aa. Equivalent to Rv2307D, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Hypothetical unknown protein.	Q7TYU9,A0A1R3Y1L6	No	conserved hypotheticals			A0A1R3Y1L6					Q7TYU9					Rv2307D		Rv2307D			
NC_002945.3	Mycobrowser_v4	CDS	2370483	2370686	.	+	0	Mb2152	Mb2152		conserved transmembrane protein	Mb2152, -, len: 67 aa. Equivalent to Rv2128, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable conserved transmembrane protein.	Q7TZ04,A0A1R3Y0C7	No	cell wall and cell processes			A0A1R3Y0C7					Q7TZ04					Rv2128		Rv2128			
NC_002945.3	Mycobrowser_v4	CDS	2370706	2371587	.	-	0	Mb2153c	Mb2153c		Probable oxidoreductase	Mb2153c, -, len: 293 aa. Equivalent to Rv2129c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 293 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to many e.g. FABG_SYNY3|P73826 3-oxoacyl-[acyl-carrier protein] reductase (240 aa), FASTA scores: opt: 241, E(): 5.1e-17,(32.7% identity in 196 aa overlap); etc. Also similar to a number of other Mycobacterium tuberculosis oxidoreductases e.g. MTCY210.04 (34.1% identity in 217 aa overlap).	Q7VEQ3,A0A1R3Y0C0	No	intermediary metabolism and respiration			A0A1R3Y0C0				IPR002198,IPR002347,IPR016040	Q7VEQ3					Rv2129c		Rv2129c			
NC_002945.3	Mycobrowser_v4	CDS	2376406	2377236	.	-	0	Mb2160c	Mb2160c		Possible conserved transmembrane protein	Mb2160c, -, len: 276 aa. Equivalent to Rv2136c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 276 aa overlap). Possible conserved transmembrane protein, very similar to hypothetical Mycobacterium leprae protein Q49783. FASTA best: Q49783 B2126_C2_190 opt: 1023, E(): 0; (82.4% identity in 187 aa over lap) similar to BACA_ECOLI P31054 bacitracin resistance protein (273 aa) opt: 477, E(): 7e-26, (35.6% identity in 267 aa overlap)	X2BK90,Q7VEQ2,Q7VEQ2	No	cell wall and cell processes			Q7VEQ2					X2BK90,Q7VEQ2					Rv2136c		Rv2136c			
NC_002945.3	Mycobrowser_v4	CDS	2373809	2374039	.	+	0	Mb2156	Mb2156		CONSERVED HYPOTHETICAL PROTEIN	Mb2156, -, len: 76 aa. Equivalent to Rv2132, len: 76 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 76 aa overlap). Conserved hypothetical protein. Function unknown but belongs to Mycobacterium tuberculosis protein family including Rv2871, Rv1241,Rv3321c, Rv1113, Rv0657c, Rv1560, Rv2104c, etc. Similarity to Mycobacterium tuberculosis protein Rv2871 (AL021924|MTV020_4, 84 aa). FASTA score: opt: 142, E(): 0.00036; 41.8% identity in 55 aa overlap	Q7TZ03,A0A1R3Y0A2	No	conserved hypotheticals			A0A1R3Y0A2				IPR002145	Q7TZ03					Rv2132		Rv2132			
NC_002945.3	Mycobrowser_v4	CDS	2374249	2375037	.	-	0	Mb2157c	Mb2157c		CONSERVED HYPOTHETICAL PROTEIN	Mb2157c, -, len: 262 aa. Equivalent to Rv2133c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49774. FASTA best: Q49774 B2126_C1_150 (262 aa) opt: 1447, E(): 0; (79.0% identity in 262 aa overlap)	Q7TZ02,A0A1R3Y2F0	No	conserved hypotheticals			A0A1R3Y2F0				IPR000403,IPR022292	Q7TZ02					Rv2133c		Rv2133c			
NC_002945.3	Mycobrowser_v4	CDS	2375699	2376409	.	-	0	Mb2159c	Mb2159c		conserved protein	Mb2159c, -, len: 236 aa. Equivalent to Rv2135c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49773. FASTA best: Q49773 B2126_C1_148 opt: 1183, E() : 0; (74.8% identity in 250 aa overlap), also similar in C-terminus to PMG2_ECOLI P36942 probable phosphoglycerate mutase 2 (215 aa), FASTA scores; opt: 212, E(): 2.5e-07 27.9% identity in 190 aa overlap; and to Rv2228 and Rv2419c	Q7TZ00,A0A1R3Y0E8	No	conserved hypotheticals			A0A1R3Y0E8				IPR013078,IPR022492	Q7TZ00					Rv2135c		Rv2135c			
NC_002945.3	Mycobrowser_v4	CDS	2377300	2377713	.	-	0	Mb2161c	Mb2161c		CONSERVED HYPOTHETICAL PROTEIN	Mb2161c, -, len: 137 aa. Equivalent to Rv2137c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein. C-terminus is very similar to hypothetical Mycobacterium leprae protein B2126_C2_188 (150 aa). FASTA best: Q49782 B2126_C2_188. (150 aa) opt: 469, E(): 9.6e-28; (77.2% identity in 101 aa overlap)	Q7TYZ9,A0A1R3Y093	No	conserved hypotheticals			A0A1R3Y093					Q7TYZ9					Rv2137c		Rv2137c			
NC_002945.3	Mycobrowser_v4	CDS	2380774	2382120	.	-	0	Mb2165c	Mb2165c		conserved protein	Mb2165c, -, len: 448 aa. Equivalent to Rv2141c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Conserved hypothetical protein. Shows some similarity to conserved hypothetical proteins and to acetylornithine deacetylase and succinyl-diaminopimelate desuccinylase and contains ArgE/dapE/ACY1/CPG2/yscS family signature 1 (PS00758). FASTA best: CBPS_YEAST P27614 carboxypeptidases precursor (576 aa) opt: 234, E(): 4.3e-08; (24.3% identity in 412 aa overlap). Previously named dapE2	Q7TYZ8,A0A1R3Y0E1	No	intermediary metabolism and respiration			A0A1R3Y0E1				IPR001261,IPR002933,IPR011650	Q7TYZ8					Rv2141c		Rv2141c			
NC_002945.3	Mycobrowser_v4	CDS	2386180	2386470	.	-	0	Mb2170c	Mb2170c		Possible conserved transmembrane protein	Mb2170c, -, len: 96 aa. Equivalent to Rv2146c, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Possible conserved transmembrane protein, orthologs present in Mycobacterium leprae, ML0921 (96 aa) and Streptomyces coelicolor. Second start taken GTG alternative upstream but much less probable in TBparse. FASTA best: Q44935 SIMILAR TO A HYPOTHETICAL INTEGRAL MEMBRANE PROT EIN (97 aa) opt: 105,E(): 0.093; (25.3% identity in 87 aa overlap). >emb|CAC31302.1| (AL583920) possible membrane protein ML0921 [Mycobacterium leprae] E(): 5e-32 (76% identity in 96 aa overlap)	Q7VEP9,A0A1R3Y0A1	No	cell wall and cell processes			A0A1R3Y0A1				IPR003425	Q7VEP9					Rv2146c		Rv2146c			
NC_002945.3	Mycobrowser_v4	CDS	2386632	2387357	.	-	0	Mb2171c	Mb2171c		CONSERVED HYPOTHETICAL PROTEIN	Mb2171c, -, len: 241 aa. Equivalent to Rv2147c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins in Mycobacterium leprae ML0920 (210 aa) and Streptomyces coelicolor. FASTA scores: >emb|CAC31301.1| (AL583920) hypothetical protein ML0920 hypothetical protein (210 aa) opt: 1242, E(): 5.7e-74; 83.486% identity in 218 aa overlap	X2BK20,Q7TYZ5,Q7TYZ5	No	conserved hypotheticals			Q7TYZ5					X2BK20,Q7TYZ5					Rv2147c		Rv2147c			
NC_002945.3	Mycobrowser_v4	CDS	2387354	2388130	.	-	0	Mb2172c	Mb2172c		conserved protein	Mb2172c, -, len: 258 aa. Equivalent to Rv2148c,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Conserved hypothetical protein; should belong to the YGGS/YBL036C/F09E5.8 family. FASTA best: AB003132|AB003132_5 Corynebacterium glutamicum gene (221 aa) opt: 440, E(): 2.3e-23; 42.8% identity in 236 aa overlap; and YPI1_VIBAL P52055 hypothetical protein in pilt-proc intergenic region in Vibrio alginolyticus. opt: 266, E(): 1.8e-11; 27.9% identity in 244 aa overlap.	X2BK84,P67084	No	conserved hypotheticals			P67084					X2BK84					Rv2148c		Rv2148c			
NC_002945.3	Mycobrowser_v4	CDS	2562647	2563501	.	-	0	Mb2340c	Mb2340c		HYPOTHETICAL PROTEIN	Mb2340c, -, len: 284 aa. Equivalent to Rv2313c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Hypothetical unknown protein.	X2BKS1,P64994	No	conserved hypotheticals			P64994					X2BKS1					Rv2313c		Rv2313c			
NC_002945.3	Mycobrowser_v4	CDS	2401145	2402179	.	-	0	Mb2183c	Mb2183c		conserved protein	Mb2183c, -, len: 344 aa. Equivalent to Rv2159c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein from Streptomyces coelicolor SC1A6.09c (337 aa,29% identity). Smith-Waterman scores: >pir||T28690 hypothetical protein - Streptomyces coelicolor >gi|3127841|emb|CAA18907.1| (AL023496) Expect = 2e-18	Q7TYZ4,A0A1R3Y0C9	No	conserved hypotheticals			A0A1R3Y0C9				IPR003779,IPR004675	Q7TYZ4					Rv2159c		Rv2159c			
NC_002945.3	Mycobrowser_v4	CDS	2407476	2408630	.	-	0	Mb2188c	Mb2188c		PROBABLE CONSERVED PROLINE RICH MEMBRANE PROTEIN	Mb2188c, -, len: 384 aa. Equivalent to Rv2164c,len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 384 aa overlap). Probable pro- rich conserved membrane protein, equivalent to ML0907|AL022602 putative conserved membrane protein from Mycobacterium leprae (377 aa) (AL022602), FASTA scores: opt: 1495, E(): 1.7e-56, (62.217% identity in 397 aa overlap).	Q7TYZ1,A0A1R3Y0H5	No	cell wall and cell processes			A0A1R3Y0H5					Q7TYZ1					Rv2164c		Rv2164c			
NC_002945.3	Mycobrowser_v4	CDS	2402176	2402796	.	-	0	Mb2184c	Mb2184c		CONSERVED HYPOTHETICAL PROTEIN	Mb2184c, -, len: 206 aa. Similar to 5' end of Rv2160A and 3' end of Rv2160c, len: 211 aa and 112 aa,from Mycobacterium tuberculosis strain H37Rv, (96.3% identity in 107 aa overlap and 92.0% identity in 112 aa overlap). Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to N-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), FASTA scores: opt: 285, E(): 1.4e-08,(51.042% identity in 96 aa overlap). Next gene, Rv2160c,is similar to C-terminal half of 2SCK31.01c suggesting possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to C-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), while Rv2160A is similar to the N-terminal half of 2SCK31.01c. This suggests possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a 4 bp insertion (*-ggaa) leads to a single product.	Q7TYZ3,A0A1R3Y0F7	No				A0A1R3Y0F7				IPR001647,IPR009057,IPR011075,IPR015893	Q7TYZ3										
NC_002945.3	Mycobrowser_v4	CDS	2402789	2403655	.	-	0	Mb2185c	Mb2185c		conserved protein	Mb2185c, -, len: 288 aa. Equivalent to Rv2161c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap). Conserved hypothetical protein; shows some similarity to protein involved in lincomycin production and to other M. tuberculosis proteins e.g. Rv0953c, Rv0791c, Rv0132c,Rv2951c, Rv1855c. FASTA best: Q54379 (78-11) LINCOMYCIN PRODUCTION GENES (295 aa) opt: 243, E(): 2.4e-09; (29.5% identity in 285 aa overlap).	Q7TYZ2,A0A1R3Y0D6	No	intermediary metabolism and respiration			A0A1R3Y0D6				IPR011251,IPR019921	Q7TYZ2					Rv2161c		Rv2161c			
NC_002945.3	Mycobrowser_v4	CDS	2442380	2442799	.	-	0	Mb2222c	Mb2222c		Possible conserved integral membrane protein	Mb2222c, -, len: 139 aa. Equivalent to Rv2199c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Possible conserved integral membrane protein, similar to hypothetical membrane proteins in Actinomycetes and equivalent to Mycobacterium leprae, ML0876, putative membrane protein (139 aa) FASTA scores: opt: 866, E(): 1.1e-43; 91.367% identity in 139 aa overlap CAC31257.1| (AL583920)	X2BKD3,P64948,P64948	No	cell wall and cell processes			P64948					X2BKD3,P64948					Rv2199c		Rv2199c			
NC_002945.3	Mycobrowser_v4	CDS	2408627	2409817	.	-	0	Mb2189c	Mb2189c		conserved protein	Mb2189c, -, len: 396 aa. Equivalent to Rv2165c,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Conserved hypothetical protein; shows strong similarity to several hypothetical bacterial proteins but has extra 80 aa residues at N-terminus FASTA best: YLXA_BACSU Q07876 hypothetical 35.3 kd protein in ftsl (311 aa) opt: 781,E(): 0; (45.6% identity in 296 aa overlap), BELONGS TO THE YABC (E.COLI), YLXA (B.SUBTILIS) FAMILY	X2BKC0,P65430,P65430	No	conserved hypotheticals			P65430					X2BKC0,P65430					Rv2165c		Rv2165c			
NC_002945.3	Mycobrowser_v4	CDS	2409819	2410250	.	-	0	Mb2190c	Mb2190c		conserved protein	Mb2190c, -, len: 143 aa. Equivalent to Rv2166c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein; shows strong similarity to several hypothetical bacterial proteins such as YLLB_BACSU P55343. Is equivalent to Mycobacterium leprae hypothetical protein ML0905 (143 aa, 92% identity) MLCB268.11c >sp|O69561|YL66_MYCLE HYPOTHETICAL 16.1 KDA PROTEIN ML0905 >gi|3080482|emb|CAA18677.1|(AL022602) >gi|13092975|emb|CAC31286.1|(AL583920). FASTA scores: ML0905|ML0905 conserved hypothetical protein (143 aa) opt: 873, E(): 3.1e-52; 92.254% identity in 142 aa overlap; YLLB_BACSU P55343 hypothetical 16.6 kd protein (143 aa) opt: 340, E(): 3.6e-17; (35.0% identity in 143 aa overlap). BELONGS TO THE YABB (E.COLI), YLLB (B.SUBTILIS),MG221 ( M.GENITALIUM) FAMILY	X2BJY0,P65437	No	conserved hypotheticals			P65437					X2BJY0					Rv2166c		Rv2166c			
NC_002945.3	Mycobrowser_v4	CDS	2410599	2411003	.	-	0	Mb2191c	Mb2191c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2191c, -, len: 134 aa. Equivalent to Rv2169c,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Probable conserved transmembrane protein, with orthologs in M. leprae, ML0904 probable membrane protein (134 aa), and Streptomyces coelicolor. FASTA scores with ML0904, opt: 767, E(): 5.1e-43; 86.567% identity in 134 aa overlap. emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1| (AL583920). TBparse score is 0.934	Q7TYZ0,A0A1R3Y0G1	No	cell wall and cell processes			A0A1R3Y0G1				IPR021401	Q7TYZ0					Rv2169c		Rv2169c			
NC_002945.3	Mycobrowser_v4	CDS	2420845	2421351	.	-	0	Mb2201c	Mb2201c		CONSERVED HYPOTHETICAL PROTEIN	Mb2201c, -, len: 168 aa. Equivalent to Rv2179c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Conserved hypothetical protein, equivalent to conserved hypothetical protein from Mycobacterium leprae ML0895 conserved hypothetical protein (171 aa). FASTA scores: opt: 977,E(): 1.4e-58; 82.530% identity in 166 aa overlap (AL022602).	Q7TYY4,A0A1R3Y0H1	No	conserved hypotheticals			A0A1R3Y0H1				IPR012337	Q7TYY4					Rv2179c		Rv2179c			
NC_002945.3	Mycobrowser_v4	CDS	2411269	2411889	.	+	0	Mb2192	Mb2192		gcn5-related n-acetyltransferase	Mb2192, -, len: 206 aa. Equivalent to Rv2170, len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Conserved hypothetical protein, equivalent to hypothetical protein ML0903 (210 aa) from Mycobacterium leprae. FASTA scores: ML0903 conserved hypothetical protein (210 aa) opt: 1045,E(): 9.1e-57; 77.143% identity in 210 aa overlap. >emb|CAA18679.1| (AL022602) >gi|13092973|emb|CAC31284.1| (AL583920).	Q7TYY9,A0A1R3Y0H2	No	intermediary metabolism and respiration			A0A1R3Y0H2				IPR000182,IPR013653,IPR016181	Q7TYY9					Rv2170		Rv2170			
NC_002945.3	Mycobrowser_v4	CDS	2412665	2413570	.	-	0	Mb2194c	Mb2194c		conserved protein	Mb2194c, -, len: 301 aa. Equivalent to Rv2172c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae conserved hypothetical protein ML0901 (304 aa). FASTA scores: opt: 1656, E(): 7.7e-98; 81.271% identity in 299 aa overlap (1-299:1-299) CAA18681.1|AL022602|13092971|CAC31282.1|AL583920. TBparse score is 0.905	Q7TYY8,A0A1R3Y0G5	No	conserved hypotheticals			A0A1R3Y0G5					Q7TYY8					Rv2172c		Rv2172c			
NC_002945.3	Mycobrowser_v4	CDS	2422336	2423619	.	+	0	Mb2203	Mb2203		alpha(1->2)mannosyltransferase	Mb2203, -, len: 427 aa. Equivalent to Rv2181, len: 427 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 427 aa overlap). Probable conserved integral membrane protein, similar to others in Mycobacterium tuberculosis e.g. Rv1159 (MTCI65.26, 431 aa). Start uncertain. FASTA scores: Z95584|MTCI65_26 (431 aa) opt: 428, E(): 8e-22; 31.2% identity in 407 aa overlap.	Q7VEN9,A0A1R3Y0E6	No	cell wall and cell processes			A0A1R3Y0E6				IPR018584	Q7VEN9					Rv2181		Rv2181			
NC_002945.3	Mycobrowser_v4	CDS	2536473	2536736	.	-	0	Mb2307c	Mb2307c		conserved hypothetical protein [SECOND PART]	Mb2307c, -, len: 87 aa. Equivalent to 3' end of Rv2286c, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv, (). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein,Rv2466c, AL021246|MTV008_22 (207 aa). FASTA score: opt: 324, E(): 8.9e-15; 30.4% identity in 194 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2286c into 2 parts, Mb2307c and Mb2308c.	Q7VEL9,A0A1R3Y0R9	No				A0A1R3Y0R9					Q7VEL9										
NC_002945.3	Mycobrowser_v4	CDS	2421361	2422248	.	-	0	Mb2202c	Mb2202c		Probable conserved integral membrane protein	Mb2202c, -, len: 295 aa. Equivalent to Rv2180c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable conserved integral membrane protein, similar to pir||T35292 probable integral membrane protein from Streptomyces coelicolor >gi|5578858|emb|CAB51260.1| (AL096872) (246 aa) (36% identity in 249 aa overlap).	Q7VEP0,A0A1R3Y0H9	No	cell wall and cell processes			A0A1R3Y0H9					Q7VEP0					Rv2180c		Rv2180c			
NC_002945.3	Mycobrowser_v4	CDS	2416480	2416920	.	-	0	Mb2197c	Mb2197c		conserved regulatory protein	Mb2197c, -, len: 146 aa. Equivalent to Rv2175c,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Conserved hypothetical protein, possibly involved in regulation. Contains possible helix-turn-helix domain at aa 31-52 (Score 1042,+2.74 SD). Equivalent to Mycobacterium leprae ML0898 putative DNA-binding protein (134 aa). FASTA scores: opt: 747; 82.090% identity in 134 aa overlap (AL022602) >gi|13092969|emb|CAC31279.1| (AL583920)	Q7VEP2,A0A1R3Y164	No	regulatory proteins			A0A1R3Y164					Q7VEP2					Rv2175c		Rv2175c			
NC_002945.3	Mycobrowser_v4	CDS	2418316	2418981	.	-	0	Mb2199c	Mb2199c		POSSIBLE TRANSPOSASE	Mb2199c, -, len: 221 aa. Equivalent to Rv2177c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 221 aa overlap). Possible IS1558 transposase (see citation below), similar to several IS element proteins and transposases but nearly identical to last 221 residues of MTCY428_23 (333 aa). FASTA scores: Z81451|MTCY428_23 Mycobacterium tuberculosis cosmid (333 aa) opt: 1491, E() : 0; 98.6% identity in 221 aa overlap.	Q7TYY5,A0A1R3Y0U4	No	insertion seqs and phages			A0A1R3Y0U4				IPR003346	Q7TYY5					Rv2177c		Rv2177c			
NC_002945.3	Mycobrowser_v4	CDS	2423620	2424363	.	-	0	Mb2204c	Mb2204c		1-acylglycerol-3-phosphate O-acyltransferase	Mb2204c, -, len: 247 aa. Equivalent to Rv2182c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Probable 1-acylglycerol-3-phosphate O-acyltransferase, similar to many e.g. in Streptomyces. Contains PS00017 ATP/GTP-binding site motif A (P-loop). FASTA scores: pir||T35503 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) homolog SC6E10.16c - Streptomyces coelicolor >gi|5689932|emb|CAB51970.1| (AL109661) hypothetical protein [Streptomyces coelicolor A3(2)] Length = 262,Expect = 6e-61 (54% identity in 215 aa overlap).	Q7VEN8,A0A1R3Y0H6	No	conserved hypotheticals			A0A1R3Y0H6				IPR002123	Q7VEN8					Rv2182c		Rv2182c			
NC_002945.3	Mycobrowser_v4	CDS	2424449	2424844	.	-	0	Mb2205c	Mb2205c		conserved protein	Mb2205c, -, len: 131 aa. Equivalent to Rv2183c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein ML0891 (MLCB268.25c, 130 aa). FASTA scores: opt: 558, E(): 8.3e-28; 61.832% identity in 131 aa overlap >gi|13092963|emb|CAC31272.1| (AL583920) (AL022602).	Q7TYY3,A0A1R3Y0F8	No	conserved hypotheticals			A0A1R3Y0F8					Q7TYY3					Rv2183c		Rv2183c			
NC_002945.3	Mycobrowser_v4	CDS	2424841	2425980	.	-	0	Mb2206c	Mb2206c		CONSERVED HYPOTHETICAL PROTEIN	Mb2206c, -, len: 379 aa. Equivalent to Rv2184c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Conserved hypothetical protein, equivalent to hypothetical protein ML0890 (415 aa) from Mycobacterium leprae and also shows some similarity to other hypothetical proteins. FASTA scores: ML0890 opt: 1949; 79.630% identity in 378 aa overlap >emb|CAA18692.1| (AL022602) >gi|13092962|emb|CAC31271.1| (AL583920) and sptr|Q55794|Q55794 HYPOTHETICAL 44.6 KD PROTEIN. (396 aa) opt: 251, E(): 3.3e-09; 25.5% identity in 384 aa overlap.	Q7TYY2,A0A1R3Y2K1	No	conserved hypotheticals			A0A1R3Y2K1				IPR016300,IPR025723,IPR027417	Q7TYY2					Rv2184c		Rv2184c			
NC_002945.3	Mycobrowser_v4	CDS	2430280	2431053	.	-	0	Mb2212c	Mb2212c		CONSERVED HYPOTHETICAL PROTEIN	Mb2212c, -, len: 257 aa. Equivalent to Rv2189c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein SC6G10.07c (385 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores: pir||T35516 hypothetical protein SC6G10.07c - Streptomyces coelicolor >gi|4539203|emb|CAB39861.1| (AL049497) Expect = 2e-08; 30% identity in 245 aa overlap. TBparse score is 0.908	Q7TYX6,A0A1R3Y0J0	No	conserved hypotheticals			A0A1R3Y0J0					Q7TYX6					Rv2189c		Rv2189c			
NC_002945.3	Mycobrowser_v4	CDS	2431148	2432305	.	-	0	Mb2213c	Mb2213c		CONSERVED HYPOTHETICAL PROTEIN	Mb2213c, -, len: 385 aa. Equivalent to Rv2190c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477, Rv1478, Rv1566c,Rv0024, that are similar to protein p60 precursors from Listeria eg Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 a a) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE PROTEIN P60 PRECURSOR (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap.	X2BJK7,P67474,P67474	No	virulence, detoxification, adaptation			P67474					X2BJK7,P67474					Rv2190c		Rv2190c			
NC_002945.3	Mycobrowser_v4	CDS	2538924	2539301	.	+	0	Mb2310	Mb2310		HYPOTHETICAL PROTEIN	Mb2310, -, len: 125 aa. Equivalent to Rv2288, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Unknown hypothetical protein	X2BKN7,P64976	No	conserved hypotheticals			P64976					X2BKN7					Rv2288		Rv2288			
NC_002945.3	Mycobrowser_v4	CDS	2432852	2434789	.	+	0	Mb2214	Mb2214		CONSERVED HYPOTHETICAL PROTEIN	Mb2214, -, len: 645 aa. Equivalent to Rv2191, len: 645 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 645 aa overlap). Conserved hypothetical protein, similar to SW:DP3A_B ACSU P13267 DNA polymerase III, alpha chain (31.3% identity in 249 aa overlap) and SW:UVRC_ECOLI P07028 excinuclease ABC subunit C (25.7% identity in 230 aa overlap). Also similar to M. tuberculosis Rv3711c (dnaQ DNA polymerase III e chain) and Rv1420 (uvrC excinuclease ABC subunit C)	Q7TYX5,A0A1R3Y0I7	No	information pathways			A0A1R3Y0I7				IPR000305,IPR006054,IPR006055,IPR012337,IPR013520	Q7TYX5					Rv2191		Rv2191			
NC_002945.3	Mycobrowser_v4	CDS	2448078	2448434	.	-	0	Mb2227c	Mb2227c		conserved protein	Mb2227c, -, len: 118 aa. Equivalent to Rv2204c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein. Similar to conserved hypothetical proteins in Actinomycetes and equivalent to Mycobacterium leprae ML0871|ML0871 conserved hypothetical protein (118 aa) and to sp|P45344|YADR_HAEIN HYPOTHETICAL PROTEIN HI1723 (114 aa). FASTA score: ML0871 opt: 720, E(): 8.4e-45; 92.373% identity in 118 aa overlapCAC31252.1| (AL583920); and P45344 opt: 346, E(): 1.8e-18; 45.6% identity in 103 aa overlap. Contains PS01152 Hypothetical hesB/y yadR/yfhF family signature	X2BKD8,P0A5B0,P0A5B0	No	conserved hypotheticals			P0A5B0					X2BKD8,P0A5B0					Rv2204c		Rv2204c			
NC_002945.3	Mycobrowser_v4	CDS	2440651	2441295	.	-	0	Mb2220c	Mb2220c		Probable conserved transmembrane protein	Mb2220c, -, len: 214 aa. Equivalent to Rv2197c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 214 aa overlap). Probable conserved transmembrane protein, equivalent to ML0878 conserved hypothetical protein (212 aa) of Mycobacterium leprae. FASTA scores: opt: 858; 62.559% identity in 211 aa overlap CAC31259.1|(AL583920)	Q7VEN7,A0A1R3Y0G0	No	cell wall and cell processes			A0A1R3Y0G0				IPR024381	Q7VEN7					Rv2197c		Rv2197c			
NC_002945.3	Mycobrowser_v4	CDS	2447378	2448070	.	+	0	Mb2226	Mb2226		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb2226, -, len: 230 aa. Equivalent to Rv2203, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Possible conserved membrane protein; has single hydrophobic stretch from aa 75 to 97 and is equivalent to Mycobacterium leprae ML0872 putative membrane protein (171 aa). FASTA scores: opt: 821, E(): 3.4e-42; 72.353% identity in 170 aa overlap -CAC31253.1| (AL583920). 2468411.	X2BK48,P64950,P64950	No	cell wall and cell processes			P64950					X2BK48,P64950					Rv2203		Rv2203			
NC_002945.3	Mycobrowser_v4	CDS	2448534	2449610	.	-	0	Mb2228c	Mb2228c		CONSERVED HYPOTHETICAL PROTEIN	Mb2228c, -, len: 358 aa. Equivalent to Rv2205c,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Conserved hypothetical protein. Very similar to YHAD_ECOLI|P23524 hypothetical protein (YHAD (E.coli) / YXAA (S14A) (B.subtilis) family) (41.6% identity in 154 aa overlap),and to other members of the glycerate kinase family. Start changed since first submission; protein now 122 aa shorter, owing to extension of Rv2206.	X2BJL5,P64289,P64289	No	conserved hypotheticals			P64289					X2BJL5,P64289					Rv2205c		Rv2205c			
NC_002945.3	Mycobrowser_v4	CDS	2449769	2450479	.	+	0	Mb2229	Mb2229		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2229, -, len: 236 aa. Equivalent to Rv2206, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Probable conserved transmembrane protein. Equivalent to hypothetical protein ML0869 (247 aa) of Mycobacterium leprae gZ98741|MLCB22_2 (247 aa), FASTA scores: opt: 1052, (67.5% identity in 237 aa overlap). Two hydrophobic stretches in C-terminal part. Start changed since original submission (+112 aa).	X2BKF6,P64952,P64952	No	cell wall and cell processes			P64952					X2BKF6,P64952					Rv2206		Rv2206			
NC_002945.3	Mycobrowser_v4	CDS	4032007	4032261	.	-	0	Mb3678c	Mb3678c		CONSERVED HYPOTHETICAL PROTEIN	Mb3678c, -, len: 84 aa. Equivalent to Rv3654c, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Hypothetical protein,similar to C-terminus of Q9X916|SCH5.14c MEMBRANE SPANNING PROTEIN from Streptomyces coelicolor (230 aa) FASTA scores: opt: 176, E(): 2.4e-05, (47.0% identity in 83 aa overlap). Equivalent to AAK48118 from Mycobacterium tuberculosis strain CDC1551 but shorter 18 aa.	Q7TW09,A0A1R3Y5A3	No	conserved hypotheticals			A0A1R3Y5A3				IPR021202	Q7TW09					Rv3654c		Rv3654c			
NC_002945.3	Mycobrowser_v4	CDS	4033485	4034285	.	-	0	Mb3682c	Mb3682c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3682c, -, len: 266 aa. Equivalent to Rv3658c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable conserved transmembrane protein, similar to Q9X920|SCH5.18c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (321 aa), FASTA scores: opt: 335, E(): 4.1e-13, (38.05% identity in 247 aa overlap).	Q7TW05,A0A1R3Y4R2	No	cell wall and cell processes			A0A1R3Y4R2				IPR018076	Q7TW05					Rv3658c		Rv3658c			
NC_002945.3	Mycobrowser_v4	CDS	2740261	2740494	.	-	0	MB2495A	MB2495A		Conserved protein	MB2495A, len: 77 aa. Equivalent to Rv2468A len: 77 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 77 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BKM4,A0A1R3Y1B3	No	conserved hypotheticals			A0A1R3Y1B3					X2BKM4					Rv2468A		Rv2468A			
NC_002945.3	Mycobrowser_v4	CDS	2452547	2454085	.	+	0	Mb2232	Mb2232		Probable conserved integral membrane protein	Mb2232, -, len: 512 aa. Equivalent to Rv2209, len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Probable conserved integral membrane protein, similar to but longer than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis (436 aa). FASTA score: opt: 712, E(): 2.8e-32; 33.4% identity in 422 aa overlap	X2BKE5,P64954,P64954	No	cell wall and cell processes			P64954					X2BKE5,P64954					Rv2209		Rv2209			
NC_002945.3	Mycobrowser_v4	CDS	2456337	2457473	.	+	0	Mb2235	Mb2235		adenylyl cyclase (atp pyrophosphate-lyase) (adenylate cyclase)	Mb2235, -, len: 378 aa. Equivalent to Rv2212, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). Conserved hypothetical protein. Some similarity to adenylate cyclases, e.g. SW:CYAA_STRCO P40135 (29.2% identity in 291 aa overlap); ttg at 24614 in MTCY190 has a better rbs. Contains possible helix-turn-helix motif at aa 64-85,(+2.72 SD). Also similar to Rv1264 and Rv1647	X2BK46,P64266,P64266	No	intermediary metabolism and respiration			P64266					X2BK46,P64266					Rv2212		Rv2212			
NC_002945.3	Mycobrowser_v4	CDS	2462773	2463678	.	+	0	Mb2239	Mb2239		conserved protein	Mb2239, -, len: 301 aa. Equivalent to Rv2216, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae ML0860 (307 aa), Z98741|MLCB22_10 Mycobacterium leprae cosmid B22; H (307 aa). FASTA score: opt: 1656, E(): 0; 84.2% identity in 297 aa overlap. Also gp|AE000319|ECAE000319_8 Escherichia coli strain K12 MG1655 (297 aa) opt: 640, E(): 0; 39.5% identity in 294 aa overlap.	X2BKG8,P67233,P67233	No	conserved hypotheticals			P67233					X2BKG8,P67233					Rv2216		Rv2216			
NC_002945.3	Mycobrowser_v4	CDS	2465382	2466134	.	+	0	Mb2242	Mb2242		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2242, -, len: 250 aa. Equivalent to Rv2219, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Probable conserved transmembrane protein. Equivalent to hypothetical membrane protein ML0857 (250 aa) from Mycobacterium leprae Z98741 |MLCB22_13 Mycobacterium leprae cosmid B22; H (250 aa) opt : 1328, E(): 0; 80.8% identity in 250 aa overlap.	Q7TYX2,A0A1R3Y0L2	No	cell wall and cell processes			A0A1R3Y0L2				IPR025445	Q7TYX2					Rv2219		Rv2219			
NC_002945.3	Mycobrowser_v4	CDS	2472984	2474546	.	-	0	Mb2247c	Mb2247c		Probable exported protease	Mb2247c, -, len: 520 aa. Equivalent to Rv2223c,len: 520 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 520 aa overlap). Probable exported protease (EC 3.4.-.-); has signal sequence. Very similar to three proteases/peptidases from Streptomyces spp.: L42758, L42759, L27466. FASTA score: L42758|STMSLPD STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% identity in 533 aa overlap). Also similar to hypothetical proteins SW:YZZE _ECOLI P34211 (25.4% identity in 406 aa overlap) and PIR:B36944 in ompP 3' region (27.5% identity in 218 aa overlap). Highly similar to Rv2224c and Rv2672 (49.3% identity in 507 aa overlap); contains PS00120 Lipases, serine active site	X2BKG1,P65822,P65822	No	cell wall and cell processes			P65822					X2BKG1,P65822					Rv2223c		Rv2223c			
NC_002945.3	Mycobrowser_v4	CDS	2481883	2482620	.	-	0	Mb2254c	Mb2254c		conserved protein	Mb2254c, -, len: 245 aa. Equivalent to Rv2229c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 245 aa overlap). Conserved hypothetical protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922)	Q7TYW9,A0A1R3Y0L9	No	conserved hypotheticals			A0A1R3Y0L9				IPR003743	Q7TYW9					Rv2229c		Rv2229c			
NC_002945.3	Mycobrowser_v4	CDS	2477979	2479520	.	+	0	Mb2250	Mb2250		conserved protein	Mb2250, -, len: 513 aa. Equivalent to Rv2226, len: 513 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 513 aa overlap). Conserved hypothetical protein, similar to hypothetical secreted protein (510 aa) from Streptomyces coelicolor A3(2) emb|CAB59601.1| (AL132662) hypothetical secreted protein [Streptomyces coelicolor. Smith-Waterman scores Expect = 5e-44 Identities = 166/506 (32%)	Q7TYX0,A0A1R3Y0J1	No	conserved hypotheticals			A0A1R3Y0J1				IPR007899,IPR023577	Q7TYX0					Rv2226		Rv2226			
NC_002945.3	Mycobrowser_v4	CDS	2845283	2845993	.	+	0	Mb2588	Mb2588		conserved protein	Mb2588, -, len: 236 aa. Equivalent to Rv2558, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Conserved hypothetical protein, highly similar only to downstream ORF Q50741|MTCY9C4.11c|Rv2557|MT2645 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (224 aa), FASTA scores: opt: 1007, E(): 4.7e-59, (69.2% identity in 224 aa overlap).	X2BKT8	No	conserved hypotheticals								X2BKT8	P65006				Rv2558		Rv2558			
NC_002945.3	Mycobrowser_v4	CDS	2480078	2480398	.	+	0	Mb2251	Mb2251		conserved hypothetical protein [FIRST PART]	Mb2251, -, len: 106 aa. Equivalent to 5' end of Rv2227, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv, (93.8% identity in 80 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins from various bacteria e.g. gb|AAK22693.1| (AE005746) conserved hypothetical protein from Caulobacter crescentus (234 aa) Smith-Waterman score = 109 bits (429),Expect = 1e-41 Identities = 83/167 (49%). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts, Mb2251 and Mb2252.	Q7VEN3,A0A1R3Y0L3	No				A0A1R3Y0L3					Q7VEN3										
NC_002945.3	Mycobrowser_v4	CDS	2480406	2480780	.	+	0	Mb2252	Mb2252		conserved hypothetical protein [SECOND PART]	Mb2252, -, len: 124 aa. Equivalent to 3' end of Rv2227, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 124 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins from various bacteria e.g. gb|AAK22693.1| (AE005746) conserved hypothetical protein from Caulobacter crescentus (234 aa) Smith-Waterman score = 109 bits (429), Expect = 1e-41 Identities = 83/167 (49%). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts, Mb2251 and Mb2252.	Q7VEN2,A0A1R3Y0M4	No				A0A1R3Y0M4				IPR018655	Q7VEN2										
NC_002945.3	Mycobrowser_v4	CDS	2488637	2489404	.	+	0	Mb2261	Mb2261		conserved protein	Mb2261, -, len: 255 aa. Equivalent to Rv2237, len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical proteins Rv0276, Rv0826,Rv1645c. FASTA score: Rv0276 gp|AL021930|MTV035_4 (306 aa) opt: 874, E(): 0; 49.6% identity in 282 aa overlap	X2BJN9,P64958,P64958	No	conserved hypotheticals			P64958					X2BJN9,P64958					Rv2237		Rv2237			
NC_002945.3	Mycobrowser_v4	CDS	2480792	2481886	.	-	0	Mb2253c	Mb2253c		multifunctional protein. has rnase h,alpha-ribazole phosphatase, and acid phosphatase activities.	Mb2253c, -, len: 364 aa. Equivalent to Rv2228c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Conserved hypothetical protein. Some similarity to phosphoglycerate mutase and ribonuclease H. Similar to CAB88177.1|AL352972 putative bifunctional protein (ribonuclease H/phosphoglycerate mutase) from Streptomyces coelicolor A3(2) (497 aa); Smith-Waterman scores: 107 bits (424),Expect = 4e-41 Identities = 160/485 (32%). Also similar in C-terminal part to Rv2419c and Rv2135c.	X2BJN1,P64956,P64956	No	information pathways			P64956					X2BJN1,P64956					Rv2228c		Rv2228c			
NC_002945.3	Mycobrowser_v4	CDS	2482617	2483756	.	-	0	Mb2255c	Mb2255c		conserved protein	Mb2255c, -, len: 379 aa. Equivalent to Rv2230c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Conserved hypothetical protein. Equivalent to Mycobacterium leprae,ML1639, conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU HYPOTHETICAL 30. 7 KD PROTEIN IN (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P53434|YRP2_LISMO HYPOTHETICAL 41.4 KD PROTEIN (373 aa) opt: 595, E(): 1e-29; 30.7% identity in 326 aa overlap	X2BK75,P0A657,P0A657	No	conserved hypotheticals			P0A657					X2BK75,P0A657					Rv2230c		Rv2230c			
NC_002945.3	Mycobrowser_v4	CDS	2486785	2487600	.	+	0	Mb2259	Mb2259		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2259, -, len: 271 aa. Equivalent to Rv2235, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 271 aa overlap). Probable conserved transmembrane protein (see first citation below); hydrophobic regions near N- and C-terminus. Similar to conserved membrane proteins in other Actinomycetes. Equivalent to Mycobacterium leprae. ML1644 (270 aa). FASTA scores: opt: 1357, E(): 1.2e-72; 74.170% identity in 271 aa overlap T44717|3150235|CAA19213.1|AL023635 13093419|CAC30595.1|AL583922.	X2BK64,P66884,P66884	No	cell wall and cell processes			P66884					X2BK64,P66884					Rv2235		Rv2235			
NC_002945.3	Mycobrowser_v4	CDS	2490324	2490800	.	-	0	Mb2263c	Mb2263c		CONSERVED HYPOTHETICAL PROTEIN	Mb2263c, -, len: 158 aa. Equivalent to Rv2239c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, similar to conserved hypothetical proteins from Mycobacterium leprae (ML1649, 140 aa) and Streptomyces coelicolor A3(2) (SCC8A.28c, 159 aa). Equivalent to ML1649 conserved hypothetical protein (140 aa). FASTA scores: ML1649 conserved hypothetical protein (140 aa) opt: 846, E(): 6.5e-45; 86.429% identity in 140 aa overlap (tr|O69479|O69479 HYPOTHETICAL 15.2 KDA PROTEIN (140 aa); and opt: 447, E(): 1.2e-21; 50.355% identity (51.825% ungapped) in 141 aa overlap. Similarity with ML1649 suggests alternative start at 251198.	X2BK67,P64960	No	conserved hypotheticals			P64960					X2BK67					Rv2239c		Rv2239c			
NC_002945.3	Mycobrowser_v4	CDS	2800307	2800558	.	-	0	Mb2546c	Mb2546c		unknown protein	Mb2546c, -, len: 83 aa. Equivalent to Rv2517c, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Hypothetical unknown protein. Equivalent to AAK46899 from Mycobacterium tuberculosis strain CDC1551 (97 aa) but shorter 14 aa.	Q7TYE4	No	conserved hypotheticals								Q7TYE4	A0A1R3Y1G2				Rv2517c		Rv2517c			
NC_002945.3	Mycobrowser_v4	CDS	2494452	2495696	.	+	0	Mb2266	Mb2266		CONSERVED HYPOTHETICAL PROTEIN	Mb2266, -, len: 414 aa. Equivalent to Rv2242, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Conserved hypothetical protein. Equivalent to ML1652 conserved hypothetical protein from Mycobacterium leprae (414 aa),and ortholog in Streptomyces coelicolor A3(2). FASTA scores: ML1652 opt: 2369, E(): 4.2e-128; 88.406% identity in 414 aa overlap (AL023635)(AL583922). some similarity at 3' end with S25203 srmR protein - Streptomyces ambofaciens (604 aa) opt: 188 E(): 9e-05; (26.4% identity in 277 aa overlap) and with SW:YAEG_HAEIN P44509 hypothetical protein HI0093 (42.3% identity in 52 aa overlap). Contains possible helix-turn-helix motif at aa 360-381 (+3.52 SD)	X2BKJ7,P63750,P63750	No	conserved hypotheticals			P63750					X2BKJ7,P63750					Rv2242		Rv2242			
NC_002945.3	Mycobrowser_v4	CDS	2506051	2506980	.	+	0	Mb2276	Mb2276		diacylglycerol kinase	Mb2276, -, len: 309 aa. Equivalent to Rv2252, len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Bacillus subtilis (e.g. BSUB0004_120), Streptomyces coelicolor A3(2) >emb|CAB61184.1| (AL132973) hypothetical protein SCF91.27c (293 aa) and P39074. FASTA scores: Z99107|BSUB0004_120 Bacillus subtilis complete genome (303 aa) opt: 397, E(): 1.7e-19; (26.4% identity in 299 aa overlap) and P390 74|BMRU_BACSU BMRU PROTEIN (297 aa) opt: 309, E(): 1.3e-13; (25.0% identity in 284 aa overlap).	Q7TYW4,A0A1R3Y113	No	lipid metabolism			A0A1R3Y113				IPR001206,IPR005218,IPR016064	Q7TYW4					Rv2252		Rv2252			
NC_002945.3	Mycobrowser_v4	CDS	2501420	2502235	.	+	0	Mb2272	Mb2272		CONSERVED HYPOTHETICAL PROTEIN	Mb2272, -, len: 271 aa. Equivalent to Rv2248, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 271 aa overlap). Conserved hypothetical protein. Very similar to hypothetical Mycobacterium tuberculosis proteins Rv3517, Rv1482c, Rv3555c, Rv3714c,Rv1073. FASTA score: MTCY06G11.02c MTCY6G11 NID: g1877284 - (289 aa) opt: 366 E(): 5.3e-18; (32.1% identity in 249 aa overlap). Some similarity to M. avium protein AF002133|AF0021 339 AF002133 NID: g2183254 (346 aa) opt: 308 E(): 5.2e-14; (28.3% identity in 254 aa overlap)	Q7TYW6,A0A1R3Y0M0	No	conserved hypotheticals			A0A1R3Y0M0				IPR011335	Q7TYW6					Rv2248		Rv2248			
NC_002945.3	Mycobrowser_v4	CDS	2503848	2504417	.	-	0	Mb2274c	Mb2274c		Possible transcriptional regulatory protein	Mb2274c, -, len: 189 aa. Equivalent to Rv2250c,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 189 aa overlap). Possible transcriptional regulatory protein, TetR family. Start unclear; ORF has been shortened since first submission to avoid overlap with Rv2251 (-30 aa). Contains probable helix-turn-helix motif (Score 2243, +6.70 SD)	X2BKJ2,Q7VEN0,Q7VEN0	No	regulatory proteins			Q7VEN0					X2BKJ2,Q7VEN0					Rv2250c		Rv2250c			
NC_002945.3	Mycobrowser_v4	CDS	2536764	2537165	.	-	0	Mb2308c	Mb2308c		conserved hypothetical protein [FIRST PART]	Mb2308c, -, len: 133 aa. Equivalent to 5' end of Rv2286c, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 133 aa overlap). Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein, Rv2466c,AL021246|MTV008_22 (207 aa). FASTA score: opt: 324, E(): 8.9e-15; 30.4% identity in 194 aa overlap. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2286c into 2 parts, Mb2307c and Mb2308c.	Q7VEL8,A0A1R3Y0T3	No				A0A1R3Y0T3				IPR001853,IPR012336	Q7VEL8										
NC_002945.3	Mycobrowser_v4	CDS	2504465	2506054	.	+	0	Mb2275	Mb2275		POSSIBLE FLAVOPROTEIN	Mb2275, -, len: 529 aa. Similar to 5' end of Rv2250A and 3' end of Rv2251, len: 139 aa and 475 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 108 aa overlap and 98.2% identity in 433 aa overlap). Rv2250A: Conserved hypothetical protein, possibly flavoprotein. Similar to N-terminus of SCF91.28c|AL132973_28 possible flavoprotein from Streptomyces coelicolor (530 aa), FASTA scores: opt: 240,E(): 1.1e-07, (39.25% identity in 107 aa overlap). Possible frameshift between nt 2525723 to 2525727. The sequences of CDC 1551 and Mycobacterium bovis are missing a single G base. Rv2251: Possible flavoprotein, probably continuation of Rv2250A, similar to MTCY164.18 from Mycobacterium tuberculosis and to several ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASES (e.g. O00116). Also some similarity to D-lactate dehydrogenases. FASTA scores: sptr|O05784|O05784 HYPOTHETICAL 56.5 KD PROTEIN. (527 aa) opt: 1019 E(): 0; (38.6% identity in 487 aa overlap) and sp|O00116|ADAS_HUMAN ALKYLDIHYDROXYACETON EPHOSPHATE SYNTHASE PRECURSOR (EC 2.5.1.26) (658 aa) opt: 558 E(): 6.2e-27; (31.3% identity in 447 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base deletion (g-*) leads to a single product.	Q7TYW5,A0A1R3Y0U3	No				A0A1R3Y0U3				IPR004113,IPR006094,IPR016164,IPR016166,IPR016167,IPR016169,IPR016171,IPR025650	Q7TYW5										
NC_002945.3	Mycobrowser_v4	CDS	2508403	2508936	.	-	0	Mb2280c	Mb2280c		CONSERVED HYPOTHETICAL PROTEIN	Mb2280c, -, len: 177 aa. Equivalent to Rv2256c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 177 aa overlap). Conserved hypothetical protein, similar to Streptomyces glaucescens ORF5 (164 aa) and Streptomyces coelicolor hypothetical protein SC4A7.19c (164 aa; emb|CAB62723.1|AL133423). FASTA scores: sptr|Q54209|Q54209 FABD, FABH, FABC, FABB, AND ORF5 (164 aa) opt: 504, E(): 3.9e-27; (44.4% identity in 162 aa overlap).	Q7TYW2,A0A1R3Y0N9	No	conserved hypotheticals			A0A1R3Y0N9				IPR021491	Q7TYW2					Rv2256c		Rv2256c			
NC_002945.3	Mycobrowser_v4	CDS	2938333	2938566	.	+	0	Mb2681	Mb2681		HYPOTHETICAL PROTEIN	Mb2681, -, len: 77 aa. Equivalent to Rv2663, len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Hypothetical unknown protein.	Q7TY60	No	conserved hypotheticals								Q7TY60	A0A1R3Y1T9				Rv2663		Rv2663			
NC_002945.3	Mycobrowser_v4	CDS	2509066	2509884	.	-	0	Mb2281c	Mb2281c		conserved protein	Mb2281c, -, len: 272 aa. Equivalent to Rv2257c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, similar to hypothetical protein SC4A7.08 from Streptomyces coelicolor (273 aa; 58% identity in 243 aa overlap). Also similar to several putative esterases and penicillin-binding proteins in M. tuberculosis e.g. Rv1923, Rv1497, Rv2463, Rv3775, Rv1922,Rv1730c.	Q7TYW1,A0A1R3Y0P6	No	conserved hypotheticals	3I7J		A0A1R3Y0P6				IPR001466,IPR012338	Q7TYW1					Rv2257c		Rv2257c			
NC_002945.3	Mycobrowser_v4	CDS	2509898	2510959	.	-	0	Mb2282c	Mb2282c		Possible transcriptional regulatory protein	Mb2282c, -, len: 353 aa. Equivalent to Rv2258c,len:353 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 353 aa overlap). Possible transcriptional regulatory protein, similar to several hypothetical proteins from C. elegans. FASTA scores: sptr|O01593|O01593 CODED FOR BY C. ELEGANS CDNA YK102 F (365 aa) opt: 577, E(): 6.4e-31; (30.5% identity in 341 aa overlap). Contains possible helix-turn helix motif at aa 47-68 (+3.65 SD)	Q7VEM7,A0A1R3Y0N3	No				A0A1R3Y0N3				IPR013216	Q7VEM7										
NC_002945.3	Mycobrowser_v4	CDS	2512286	2512921	.	+	0	Mb2284	Mb2284		CONSERVED HYPOTHETICAL PROTEIN	Mb2284, -, len: 211 aa. Equivalent to Rv2260, len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins Rv0634c, Rv1637c, Rv3677c, Rv2581c from Mycobacterium tuberculosis and to various hydrolases. FASTA scores: sptr|O06154|O06154 HYPOTHETICAL 21.3 KD PROTEIN (200 aa) opt: 355, E(): 4e-15; (37.4% identity in 198 aa overlap).	Q7TYW0,A0A1R3Y1H3	No	conserved hypotheticals			A0A1R3Y1H3				IPR001279	Q7TYW0					Rv2260		Rv2260			
NC_002945.3	Mycobrowser_v4	CDS	2512998	2514506	.	-	0	Mb2285c	Mb2285c		CONSERVED HYPOTHETICAL PROTEIN	Mb2285c, -, len: 502 aa. Equivalent to Rv2262c and Rv2261c, len: 360 aa and 140 aa, from Mycobacterium tuberculosis strain H37Rv, (94.7% identity in 357 aa overlap and 100.0% identity in 140 aa overlap). Conserved hypothetical protein, with function unknown but some similarity to N-terminal 70% of P23930|P77703|LNT_ECOLI|CUTE|B0657 APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) from Escherichia coli strain K12 (512 aa), FASTA scores: opt: 239, E(): 1.6e-07,(30.4% identity in 359 aa overlap). Note that neighboring ORF shows similarity to N -terminal part of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp.,suggesting possibility of frameshift. Sequence of clones from two sources has been checked but no error found. Appear to be two extra bases at position 1876970 compared to CDC1551 strain. Conserved hypothetical protein, with function unknown but some similarity to C-terminal end of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp. Note that next ORF shows similarity to N-terminal part of P74055 APOLIPOPROTEIN N-ACYLTRANSFERASE from Escherichia coli (519 aa), FASTA scores: opt: 142,E(): 0.007, (29.9% identity in 117 aa overlap), suggesting possible frameshift. Sequence of clones from two sources has been checked but no error found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2262c and Rv2261c exist as 2 genes. In Mycobacterium bovis, a 2 bp deletion (ct-*) results in a single product which is more similar to Rv2262c.	Q7TYV9,A0A1R3Y0V4	No	lipid metabolism			A0A1R3Y0V4				IPR003010,IPR004563	Q7TYV9					Rv2262c		Rv2262c			
NC_002945.3	Mycobrowser_v4	CDS	2514595	2515548	.	+	0	Mb2286	Mb2286		Possible oxidoreductase	Mb2286, -, len: 317 aa. Equivalent to Rv2263, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 PROBABLY AN NADP-DEPENDENT OXIDOREDUCTASE (297 aa) opt: 487, E(): 1.1e-23; (36.1% identity in 299 aa overlap). Also similar to M. tuberculosis Rv0068, and Rv0439c.	Q7VEM5,A0A1R3Y124	No	intermediary metabolism and respiration			A0A1R3Y124				IPR002198,IPR002347,IPR016040	Q7VEM5					Rv2263		Rv2263			
NC_002945.3	Mycobrowser_v4	CDS	2525837	2526706	.	+	0	Mb2298	Mb2298		CONSERVED HYPOTHETICAL PROTEIN	Mb2298, -, len: 289 aa. Equivalent to Rv2275, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Conserved hypothetical protein. Some similarity to Bacillus subtilis sp|O34351|O34351 YVMC (248 aa), FASTA score: opt: 280,E(): 2.7e -11; 28.2% identity in 227 aa overlap	Q7TYV7,A0A1R3Y0S3	No	conserved hypotheticals			A0A1R3Y0S3					Q7TYV7					Rv2275		Rv2275			
NC_002945.3	Mycobrowser_v4	CDS	2515526	2517304	.	-	0	Mb2287c	Mb2287c		conserved hypothetical proline rich protein	Mb2287c, -, len: 592 aa. Equivalent to Rv2264c,len: 592 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 592 aa overlap). Conserved hypothetical Pro-rich protein, similar to hypothetical proteins Rv0312 (MTCY63.17, 620 aa and Rv0350) that has highly Pro-, Thr-rich C-terminus. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. FASTA scores: Z96800|MTCY63_17 Mycobacterium tuberculosis cosmid (620 aa) opt: 1075, E(): 8.8e-24; (38.9% identity in 627 aa overlap).	Q7VEM4,A0A1R3Y0M5	No	conserved hypotheticals			A0A1R3Y0M5				IPR013126	Q7VEM4					Rv2264c		Rv2264c			
NC_002945.3	Mycobrowser_v4	CDS	4334830	4335594	.	+	0	Mb3943	Mb3943		HYPOTHETICAL ALANINE RICH PROTEIN	Mb3943, -, len: 254 aa. Equivalent to Rv3912, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Hypothetical unknown ala-rich protein.	Q7TVC9,A0A1R3Y5P5	No	conserved hypotheticals			A0A1R3Y5P5					Q7TVC9					Rv3912		Rv3912			
NC_002945.3	Mycobrowser_v4	CDS	2517654	2518883	.	+	0	Mb2288	Mb2288		Possible conserved integral membrane protein	Mb2288, -, len: 409 aa. Equivalent to Rv2265, len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Possible conserved integral membrane protein, with some similarity to others e.g. M. thermoauto. sp|O26855|O26855 CONSERVED PROTEIN (383 aa), FASTA score: opt: 898 z-score: 1023.5 E(): 0; 38.0% identity in 384 aa overlap; Q58713 HYPOTHETICAL 44.1 KD PROTEIN 1 317 (398 aa), FASTA scores, opt: 305 E(): 1.2e-11; 22.8% identity in 382 aa overlap; also KGTP_ECOLI P17448 alpha-ketoglutarate permease (432 aa), FASTA scores, opt: 156, E(): 0.006, (24.8% identity in 416 aa overlap)	X2BK80,P64962,P64962	No	cell wall and cell processes			P64962					X2BK80,P64962					Rv2265		Rv2265			
NC_002945.3	Mycobrowser_v4	CDS	2520598	2521764	.	-	0	Mb2290c	Mb2290c		CONSERVED HYPOTHETICAL PROTEIN	Mb2290c, -, len: 388 aa. Equivalent to Rv2267c,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Conserved hypothetical protein; some similarity to Mycobacterium tuberculosis Rv3529c; gp|Z82098|MTCY3C7_27 (384 aa) FASTA score: opt: 261, E(): 3.6e-10; 27.3% identity in 253 aa overlap	X2BJR9,P64964	No	conserved hypotheticals			P64964					X2BJR9					Rv2267c		Rv2267c			
NC_002945.3	Mycobrowser_v4	CDS	2528078	2528977	.	-	0	Mb2300c	Mb2300c		Possible glycerolphosphodiesterase	Mb2300c, -, len: 299 aa. Equivalent to Rv2277c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.661% identity in 295 aa overlap). Possible glycerolphosphodiesterase, similar to e.g. UGPQ_ECOLI P10908 glycerophosphoryldiester phosphodiesterase (cytosolic) (247 aa), FASTA scores, opt: 149, E(): 0.0061,(27.2% identity in 195 aa overlap). Start of protein uncertain, encoded by neighbouring IS6110 as given, is intact in Mycobacterium tuberculosis CDC1551. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 1358 bp deletion containing an IS6110 sequence prior to the start of Mb2300c disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa).	Q7VEM2,A0A1R3Y0R7	No	intermediary metabolism and respiration			A0A1R3Y0R7				IPR004129,IPR017946	Q7VEM2					Rv2277c		Rv2277c			
NC_002945.3	Mycobrowser_v4	CDS	2529156	2530535	.	+	0	Mb2301	Mb2301		Probable dehydrogenase	Mb2301, -, len: 459 aa. Equivalent to Rv2280, len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap	Q7VEM1,A0A1R3Y0P8	No	intermediary metabolism and respiration			A0A1R3Y0P8				IPR004113,IPR006094,IPR016164,IPR016166,IPR016167,IPR016169,IPR016171	Q7VEM1					Rv2280		Rv2280			
NC_002945.3	Mycobrowser_v4	CDS	2532534	2533472	.	-	0	Mb2303c	Mb2303c		Probable transcription regulator (lysR family)	Mb2303c, -, len: 312 aa. Equivalent to Rv2282c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 312 aa overlap). Probable transcriptional regulator, lysR family, similar to others e.g. YC30_CYAPA|P48271 hypothetical transcriptional regulator YCF30 (324 aa), FASTA scores: opt: 292, E(): 4e-12, (27.6% identity in 286 aa overlap); etc. Also similar to Rv0377|MTCY39.34 from Mycobacterium tuberculosis, FASTA score: (25.4% identity in 268 aa overlap). Contains PS00044 Bacterial regulatory proteins,lysR family signature, and contains helix-turn-helix motif at aa 24 -45 (+4.93 SD).	X2BKM0,P67668,P67668	No	regulatory proteins			P67668					X2BKM0,P67668					Rv2282c		Rv2282c			
NC_002945.3	Mycobrowser_v4	CDS	2533537	2533731	.	+	0	Mb2304	Mb2304		HYPOTHETICAL PROTEIN	Mb2304, -, len: 64 aa. Equivalent to Rv2283, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Unknown protein; questionable ORF	X2BJU4,P64974	No	conserved hypotheticals			P64974					X2BJU4					Rv2283		Rv2283			
NC_002945.3	Mycobrowser_v4	CDS	2739807	2740310	.	-	0	Mb2495c	Mb2495c		conserved protein	Mb2495c, -, len: 167 aa. Equivalent to Rv2468c,len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Conserved hypothetical protein, highly similar to Mycobacterium leprae HYPOTHETICAL PROTEINS Q9CC58|ML1255 (163 aa), FASTA scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa overlap) and Q9X7B5|MLCB1610.16 (169 aa), FASTA scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa overlap). Also weak similarity with Q9X8D7|SCE39.14c PUTATIVE GNTR-FAMILY REGULATOR from Streptomyces coelicolor (243 aa), FASTA scores: opt: 116, E(): 1.3,(30.1% identity in 156 aa overlap).	Q7TYI6,A0A1R3Y1B1	No	conserved hypotheticals			A0A1R3Y1B1					Q7TYI6					Rv2468c		Rv2468c			
NC_002945.3	Mycobrowser_v4	CDS	2535069	2536406	.	+	0	Mb2306	Mb2306		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb2306, -, len: 445 aa. Equivalent to Rv2285, len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Conserved hypothetical protein, member of Mycobacterium tuberculosis 15-membered protein family including Rv3740c, Rv3734c,Rv1425, Rv1760, Rv0895, Rv3480c. FASTA scores: gp|Z95844|MTCY493_29 Mycobacterium tuberculosis cosmid (459 aa) opt: 640, E(): 0; 33.4% identity in 470 aa overlap.	X2BKE0,P67207,P67207	No	lipid metabolism			P67207					X2BKE0,P67207					Rv2285		Rv2285			
NC_002945.3	Mycobrowser_v4	CDS	2541622	2542626	.	-	0	Mb2315c	Mb2315c		hypothetical protein	Mb2315c, -, len: 334 aa. Similar to Rv2293c and Rv2292c, len: 246 aa and 74 aa, from Mycobacterium tuberculosis strain H37Rv, (92.2% identity in 245 aa overlap and 100.0% identity in 74 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein (299 aa) AAK24237.1| (AE005897) belonging to phosphorylase family [Caulobacter crescentus] (33% identity in 131 aa overlap). Possible lipoprotein: signal peptide at N-terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-g) results in a single product which is more similar to Rv2293c.	X2BKP3,P64978,P64978	No				P64978					X2BKP3,P64978										
NC_002945.3	Mycobrowser_v4	CDS	2542921	2544144	.	+	0	Mb2316	Mb2316		Probable aminotransferase	Mb2316, -, len: 407 aa. Equivalent to Rv2294, len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Probable aminotransferase (EC 2.6.1.-), similar to others in M. tuberculosis e.g. MTV030_19, also similar to PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa), FASTA scores: opt: 563, E(): 2 .8e-29, (31.4% identity in 408 aa overlap); and to MALY_ECOLI|P23256 maly protein from Escherichia coli (390 aa), FASTA scores: opt: 530, E(): 3.6e-27, (31.3% identity in 384 aa overlap). BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.	X2BKE7,P63503,P63503	No	intermediary metabolism and respiration			P63503					X2BKE7,P63503					Rv2294		Rv2294			
NC_002945.3	Mycobrowser_v4	CDS	2544367	2545005	.	+	0	Mb2317	Mb2317		CONSERVED HYPOTHETICAL PROTEIN	Mb2317, -, len: 212 aa. Equivalent to Rv2295, len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 212 aa overlap). Conserved hypothetical protein, cysteine-rich protein, similar to YIEJ_ECOLI P31469 hypothetical 22.5 kd protein in tnab-bglb intergenic region (195 aa), opt: 270, E(): 3.4e-11, (36.4% identity in 198 aa overlap). Alternative start suggested by similarity 26 codons further downstream	X2BK96,P67310	No	conserved hypotheticals			P67310					X2BK96					Rv2295		Rv2295			
NC_002945.3	Mycobrowser_v4	CDS	2545099	2546001	.	+	0	Mb2318	Mb2318		Probable haloalkane dehalogenase	Mb2318, -, len: 300 aa. Equivalent to Rv2296, len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable haloalkane dehalogenase (EC 3.8.1.5), similar to e.g. HALO_XANAU P22643, haloalkane dehalogenase, (310 aa), opt: 510 z-score: 577.7 E(): 3.1e-25 (39.0% identity in 315 aa overlap).	X2BKN5,P64302,P64302	No	intermediary metabolism and respiration			P64302					X2BKN5,P64302					Rv2296		Rv2296			
NC_002945.3	Mycobrowser_v4	CDS	2546677	2547648	.	+	0	Mb2320	Mb2320		conserved protein	Mb2320, -, len: 323 aa. Equivalent to Rv2298, len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Conserved hypothetical protein. Similar to SLR0545 Synechocystis sp,Q55493 hypothetical 34.6 kDa protein (314 aa), FASTA scores, opt: 427, E(): 1.7e-20, (39.3% identity in 303 aa overlap) and to YZAE_BACSU P46905 hypothetical protein in natb 3'region (268 aa) FASTA scores, opt: 370, E(): 6.1e-17, (31.4% identity in 264 aa overlap)	X2BKP9,P63485,P63485	No	conserved hypotheticals			P63485					X2BKP9,P63485					Rv2298		Rv2298			
NC_002945.3	Mycobrowser_v4	CDS	2554703	2555296	.	+	0	Mb2328	Mb2328		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb2328, -, len: 197 aa. Equivalent to Rv2306A, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Possible conserved membrane protein, similar to several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor, e.g. Rv0625c|P96915|Y625_MYCTU HYPOTHETICAL 25.2 KDA PROTEIN from Mycobacterium tuberculosis (246 aa),FASTA scores: opt: 410, E(): 2.7e-17, (53.25% identity in 139 aa overlap). First 140 aa show high similarity, this then decreases but continues in next ORF Rv2306B,suggesting a frameshift near nt 2577473. However the sequence has been checked and no error found. The sequence is identical in CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand.	Q7TYV4,A0A1R3Y0V2	No	cell wall and cell processes			A0A1R3Y0V2					Q7TYV4					Rv2306A		Rv2306A			
NC_002945.3	Mycobrowser_v4	CDS	2549671	2550603	.	-	0	Mb2322c	Mb2322c		conserved protein	Mb2322c, -, len: 310 aa. Equivalent to Rv2300c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Conserved hypothetical protein, similar to others e.g. Q9RXY2|DR0172 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (271 aa), FASTA scores: opt: 306, E(): 1.3e-12, (34.6% identity in 229 aa overlap); Q9HZH1|PA3037 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (288 aa),FASTA scores: opt: 248, E(): 7.9e-09, (31.5% identity in 238 aa overlap); Q9PDL8|XF1361 HYPOTHETICAL PROTEIN from Xylella fastidiosa (279 aa), FASTA scores: opt: 236, E(): 4.6e-08, (29.7% identity in 249 aa overlap); U70053|XCU70053_3 GumP PROTEIN from Xanthomonas campestris (282 aa), FASTA scores: opt: 222, E(): 3.7e-07, (30.1% identity in 248 aa overlap); etc.	X2BK98,P64982,P64982	No	conserved hypotheticals			P64982					X2BK98,P64982					Rv2300c		Rv2300c			
NC_002945.3	Mycobrowser_v4	CDS	2569443	2570321	.	-	0	Mb2346c	Mb2346c		universal stress protein family protein	Mb2346c, -, len: 292 aa. Equivalent to Rv2319c,len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Hypothetical unknown protein.	X2BKH4,P64996,P64996	No	virulence, detoxification, adaptation			P64996					X2BKH4,P64996					Rv2319c		Rv2319c			
NC_002945.3	Mycobrowser_v4	CDS	2551408	2551650	.	+	0	Mb2324	Mb2324		conserved protein	Mb2324, -, len: 80 aa. Equivalent to Rv2302, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Conserved hypothetical protein, highly similar to others: O53766|AL021942|Rv0569|MTV039.07 HYPOTHETICAL 9.5 KDA PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: 300, E(): 1.4e-14, (61.85% identity in 76 aa overlap); O88049|SCI35.11 HYPOTHETICAL 7.1 KDA PROTEIN from Streptomyces coelicolor (64 aa), FASTA scores: opt: 169, E(): 1.5e-05, (46.55% identity in 58 aa overlap) (has its C-terminus shorter); Q9XCD1 HYPOTHETICAL 12.0 KDA PROTEIN (FRAGMENT) from Thermomonospora fusca (106 aa),FASTA scores: opt: 126, E(): 0.023, (50.0% identity in 34 aa overlap) (similarity in part for this one). Also weakly similar to U650M|G699303|Q50105 HYPOTHETICAL 5.7 KDA PROTEIN from Mycobacterium leprae (53 aa), FASTA scores: opt: 89, E(): 0.66, (45.5% identity in 33 aa overlap); and weakly similar to N-terminus of Q9RIZ1|SCJ1.23c putative DNA-binding protein from Streptomyces coelicolor (323 aa),FASTA scores: opt: 182, E(): 7.3e-06, (42.25% identity in 71 aa overlap).	X2BJY1,P64984	No	conserved hypotheticals			P64984					X2BJY1					Rv2302		Rv2302			
NC_002945.3	Mycobrowser_v4	CDS	2551691	2552614	.	-	0	Mb2325c	Mb2325c		PROBABLE ANTIBIOTIC-RESISTANCE PROTEIN	Mb2325c, -, len: 307 aa. Equivalent to Rv2303c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Probable antibiotic-resistance protein, with some similarity to Q54229|G153373 macrotetrolide antibiotic-resistance protein (NONR) from Streptomyces griseus (347 aa) (see the first citation below), FASTA scores: opt: 438, E(): 3.1e-21, (33.2% identity in 226 aa overlap); and other hypothetical proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 252,E(): 3.5e-09, (25.5% identity in 286 aa overlap). Also similar to Mycobacterium tuberculosis Rv3510c|O53555|MTV023.17. Note that the protein Q9XDF3|NONC from Streptomyces griseus subsp. griseus (317 aa) is equivalent to Q54229|G153373|NONR however the N-terminal end is shorter (30 aa) owing to a changed start codon (see the second citation below).	Q7TYV6,A0A1R3Y165	No	virulence, detoxification, adaptation			A0A1R3Y165				IPR006992	Q7TYV6					Rv2303c		Rv2303c			
NC_002945.3	Mycobrowser_v4	CDS	2552611	2552820	.	-	0	Mb2326c	Mb2326c		HYPOTHETICAL PROTEIN	Mb2326c, -, len: 69 aa. Equivalent to Rv2304c, len: 69 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 69 aa overlap). Hypothetical unknown protein.	X2BKF8,P64986	No	conserved hypotheticals			P64986					X2BKF8					Rv2304c		Rv2304c			
NC_002945.3	Mycobrowser_v4	CDS	2553404	2554693	.	+	0	Mb2327	Mb2327		unknown protein	Mb2327, -, len: 429 aa. Equivalent to Rv2305, len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 429 aa overlap). Hypothetical unknown protein.	Q7TYV5,A0A1R3Y0U0	No	conserved hypotheticals			A0A1R3Y0U0				IPR001242	Q7TYV5					Rv2305		Rv2305			
NC_002945.3	Mycobrowser_v4	CDS	2555083	2555517	.	+	0	Mb2329	Mb2329		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb2329, -, len: 144 aa. Equivalent to Rv2306B, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible conserved membrane protein, similar to C-terminal part of several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor e.g. P96915|Y625_MYCTU|RV0625c HYPOTHETICAL 25.2 KDA PROTEIN from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 480, E(): 5e-24, (77.15% identity in 92 aa overlap). Could be a continuation of Rv2306A suggesting there may be a frameshift near nt 2577473. The C-terminal part is longer than Rv0625c and the 3'-end of gene overlaps Rv2307c, so maybe a further framehift. However, sequence has been checked and no error found. Also same sequence as strain CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand.	Q7TYV3,A0A1R3Y0T8	No	cell wall and cell processes			A0A1R3Y0T8				IPR015414	Q7TYV3					Rv2306B		Rv2306B			
NC_002945.3	Mycobrowser_v4	CDS	2555446	2556291	.	-	0	Mb2330c	Mb2330c		CONSERVED HYPOTHETICAL PROTEIN	Mb2330c, -, len: 281 aa. Equivalent to Rv2307c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 281 aa overlap). Conserved hypothetical protein, similar to many other hypothetical proteins and BEM1/BUD5 suppressors e.g. P77538 HYPOTHETICAL PROTEIN from Escherichia coli (293 aa), FASTA scores: opt: 421,E(): 2.4e-18, (32.1% identity in 268 aa overlap) (alias AAG57647|Z3802|BAB36823|ECS3400 Putative enzyme (3.4.-) from Escherichia coli (293 aa), FASTA scores: opt: 425,E(): 1.7e-18, (32.1% identity in 268 aa overlap));P54069|BE46_SCHPO|BEM46|SPBC32H8.03|PI020 BEM46 PROTEIN from Schizosaccharomyces pombe (Fission yeast) (352 aa), FASTA scores: opt: 355, E(): 3.3e-14, (30.45% identity in 279 aa overlap); O76462|BEM46 BEM46 PROTEIN from Drosophila melanogaster (338 aa), FASTA scores: opt: 404, E(): 2.8e-17, (32.75% identity in 281 aa overlap); etc. Equivalent (but with few differences) to AAK46650|MT2364 protein from Mycobacterium tuberculosis strain CDC1551 (281 aa).	Q7TYV2,A0A1R3Y0V0	No	conserved hypotheticals			A0A1R3Y0V0					Q7TYV2					Rv2307c		Rv2307c			
NC_002945.3	Mycobrowser_v4	CDS	2558014	2558730	.	+	0	Mb2334	Mb2334		CONSERVED HYPOTHETICAL PROTEIN	Mb2334, -, len: 238 aa. Equivalent to Rv2308, len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 238 aa overlap). Conserved hypothetical protein, sharing similarity with O53464|Rv2018|MTV018.05 from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 142, E(): 0.034, (24.8% identity in 250 aa overlap). As contains possible helix-turn-helix motif at aa 16-37 (Sequence: YVYAEVDKLIGLPAGTAKRWIN) (Score 1169, +3.17 SD),may be a transcriptional regulator.	Q7TYU8,A0A1R3Y108	No	conserved hypotheticals			A0A1R3Y108				IPR007367,IPR009057,IPR011991,IPR017277	Q7TYU8					Rv2308		Rv2308			
NC_002945.3	Mycobrowser_v4	CDS	2753377	2753700	.	-	0	Mb2506c	Mb2506c		HYPOTHETICAL PROTEIN	Mb2506c, -, len: 107 aa. Equivalent to Rv2481c,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 107 aa overlap). Hypothetical unknown protein.	Q7TYH6	No	conserved hypotheticals								Q7TYH6	A0A1R3Y1C8				Rv2481c		Rv2481c			
NC_002945.3	Mycobrowser_v4	CDS	2559438	2559893	.	-	0	Mb2335c	Mb2335c		POSSIBLE INTEGRASE (FRAGMENT)	Mb2335c, -, len: 151 aa. Equivalent to Rv2309c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Possible integrase (fragment), similar to others e.g. Q48908 INTEGRASE (FRAGMENT) from Mycobacterium paratuberculos (191 aa),FASTA scores: opt: 279, E(): 3.2e-11, (40.4% identity in 136 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1055|MTV017.08 INTEGRASE (FRAGMENT) (78 aa) (72.85% identity in 70 aa overlap); and Rv1054|MTV017.07 INTEGRASE (FRAGMENT). COULD BELONG TO THE 'PHAGE' INTEGRASE FAMILY.	Q7TYU7,A0A1R3Y177	No	insertion seqs and phages			A0A1R3Y177				IPR002104,IPR011010,IPR013762,IPR014417	Q7TYU7					Rv2309c		Rv2309c			
NC_002945.3	Mycobrowser_v4	CDS	2560640	2560927	.	+	0	Mb2336	Mb2336		HYPOTHETICAL PROTEIN	Mb2336, -, len: 95 aa. Equivalent to Rv2309A, len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 95 aa overlap). Hypothetical unknown protein. Equivalent to AAK46663 from Mycobacterium tuberculosis strain CDC1551 (95 aa) but longer 13 aa.	Q7TYU6,A0A1R3Y0R5	No	conserved hypotheticals			A0A1R3Y0R5					Q7TYU6					Rv2309A		Rv2309A			
NC_002945.3	Mycobrowser_v4	CDS	2561030	2561374	.	+	0	Mb2337	Mb2337		POSSIBLE EXCISIONASE	Mb2337, -, len: 114 aa. Equivalent to Rv2310, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Possible excisionase,showing some similarity to others e.g. Q9LCU5 PUTATIVE EXCISIONASE from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 341, E(): 6.6e-15, (48.2% identity in 110 aa overlap); O85865 PUTATIVE EXCISIONASE from Sphingomonas aromaticivorans (152 aa), FASTA scores: opt: 205, E(): 2.2e-06, (41.25% identity in 80 aa overlap); etc. Also similar to Rv3750c|O69717 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 228, E(): 6.9e-08, (43.9% identity in 82 aa overlap). Contains possible helix-turn-helix motif at aa 20-41 (Score 2181, +6.62 SD).	X2BKA7,P64988,P64988	No	insertion seqs and phages			P64988					X2BKA7,P64988					Rv2310		Rv2310			
NC_002945.3	Mycobrowser_v4	CDS	2561479	2562003	.	+	0	Mb2338	Mb2338		CONSERVED HYPOTHETICAL PROTEIN	Mb2338, -, len: 174 aa. Equivalent to Rv2311, len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Conserved hypothetical protein, with similarity (in part) to transfer proteins homologous TRAA e.g. Q9EUN8|TRAA TRANSFER PROTEIN HOMOLOG TRAA from Corynebacterium glutamicum (1160 aa), FASTA scores: opt: 221, E(): 2.9e-07, (36.8% identity in 136 aa overlap); Q9ETQ3|TRAA CONJUGAL TRANSFER PROTEIN (TRAA-LIKE PROTEIN) from Corynebacterium equii (1367 aa), FASTA scores: opt: 188,E(): 5.5e-05, (33% identity in 106 aa overlap); P55418|TRAA_RHISN|Y4DS PROBABLE CONJUGAL TRANSFER PROTEIN from Rhizobium sp. strain NGR234 (1102 aa), FASTA scores: opt: 145, E(): 0.035, (29.08% identity in 141 aa overlap); etc.	X2BKQ1,P64990	No	conserved hypotheticals			P64990					X2BKQ1					Rv2311		Rv2311			
NC_002945.3	Mycobrowser_v4	CDS	2562081	2562350	.	+	0	Mb2339	Mb2339		HYPOTHETICAL PROTEIN	Mb2339, -, len: 89 aa. Equivalent to Rv2312, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Hypothetical unknown protein.	X2BK08,P64992	No	conserved hypotheticals			P64992					X2BK08					Rv2312		Rv2312			
NC_002945.3	Mycobrowser_v4	CDS	2563512	2564885	.	-	0	Mb2341c	Mb2341c		conserved protein	Mb2341c, -, len: 457 aa. Equivalent to Rv2314c,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 457 aa overlap). Conserved hypothetical protein, highly similar to Q9RJ51|SCI8.02 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (464 aa) FASTA scores: opt: 1485, E(): 5.2e-83, (53.5% identity in 454 aa overlap); similar to AAK24788|CC2824 TldD/PmbA family protein from Caulobacter crescentus (441 aa), FASTA scores: opt: 364, E(): 8.3e-15, (29.8% identity in 460 aa overlap); and showing similarity with Q9HJZ6|TA0814 HYPOTHETICAL PROTEIN from Thermoplasma acidophilum (430 aa), FASTA scores: opt: 220, E(): 4.7e-06, (21.85% identity in 348 aa overlap).	Q7TYU5,A0A1R3Y0T7	No	conserved hypotheticals			A0A1R3Y0T7				IPR002510	Q7TYU5					Rv2314c		Rv2314c			
NC_002945.3	Mycobrowser_v4	CDS	2564882	2566399	.	-	0	Mb2342c	Mb2342c		conserved protein	Mb2342c, -, len: 515 aa. Equivalent to Rv2315c,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 505 aa overlap). Conserved hypothetical protein, highly similar to Q9S273|SCI28.10 HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (435 aa), FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46, (42.8% identity in 505 overlap); O58578|PH0848 HYPOTHETICAL 54.4 KDA PROTEIN from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661,E(): 4.3e-33, (29.95% identity in 484 aa overlap); Q9UZ95|PAB1547 HYPOTHETICAL 53.6 KDA PROTEIN from Pyrococcus abyssi (473 aa), FASTA scores: opt: 656, E(): 8.6e-33, (29.1% identity in 481 aa overlap); etc.	Q7TYU4,A0A1R3Y309	No	conserved hypotheticals			A0A1R3Y309				IPR002510	Q7TYU4					Rv2315c		Rv2315c			
NC_002945.3	Mycobrowser_v4	CDS	2577583	2578074	.	+	0	Mb2354	Mb2354		conserved protein	Mb2354, -, len: 163 aa. Equivalent to Rv2327, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, similar to Z80775|MTCY21D4.05c|Rv0042c from Mycobacterium tuberculosis (208 aa), FASTA scores: opt: 242, E(): 5e-08,(43.0% identity in 107 aa overlap). Also slight similarity to putative transcriptional regulatory proteins belonging to the MARR-FAMILY e.g. Q9CCY2/ML2696 from Mycobacterium leprae (243 aa), FASTA scores: opt: 245, E(): 3.7e-08,(35.35% identity in 150 aa overlap); Q9L135|SC6D11.20 from Streptomyces coelicolor (155 aa), FASTA scores: opt: 242,E(): 3.9e-08, (34.75% identity in 141 aa overlap); etc.	Q7TYT5,A0A1R3Y131	No	conserved hypotheticals			A0A1R3Y131				IPR000835,IPR011991	Q7TYT5					Rv2327		Rv2327			
NC_002945.3	Mycobrowser_v4	CDS	2572956	2573864	.	-	0	Mb2350c	Mb2350c		conserved protein	Mb2350c, -, len: 302 aa. Equivalent to Rv2323c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Conserved hypothetical protein, highly similar to others eg Q9FC91|2SCG58.22 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (288 aa), FASTA scores: opt: 561, E(): 7.3e-28,(46.95% identity in 279 aa overlap); P74535|SLL1336 HYPOTHETICAL 78.3 KDA PROTEIN from Synechocystis sp. (705 aa), FASTA scores: opt: 555, E(): 2.1e-27, (37.75% identity in 265 aa overlap); etc. Also similar to various hydrolases e.g. Q53797 BETA-HYDROXYLASE (BLEOMYCIN/PHLEOMYCIN BINDING PROTEIN, ANKYRIN HOMOLOGUE,BLEOMYCIN AND TRANSPORT PROTEIN) from Streptomyces verticillus (326 aa), FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in 303 aa overlap); Q9X7M4|DDAH_STRCO|SC5F2A.01c NG,NG-dimethylarginine dimethylaminohydrolase (EC 3.5.3.18) (Dimethylargininase) (Dimethylarginine dimethylaminohydrolase) (258 aa), FASTA scores: opt: 209, E(): 4.9e-06, (27.15% identity in 243 aa overlap); G434715 beta-hydroxylase (bleomicin/phleomycin binding protein) from Streptomyces verticillus (326 aa),FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in 303 aa overlap); etc.	Q7TYT7,A0A1R3Y0X5	No	conserved hypotheticals			A0A1R3Y0X5				IPR003198	Q7TYT7					Rv2323c		Rv2323c			
NC_002945.3	Mycobrowser_v4	CDS	2573929	2574375	.	+	0	Mb2351	Mb2351		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY)	Mb2351, -, len: 148 aa. Equivalent to Rv2324, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Probable transcriptional regulatory protein, asnC-family, similar to other PUTATIVE ASNC-FAMILY REGULATORY PROTEINS e.g. Q9L101|SCL6.15C from Streptomyces coelicolor (150 aa) FASTA scores: opt: 466, E(): 2.4e-24, (52.8% identity in 142 aa overlap); Q9RKY4|SC6D7.14 PUTATIVE ASNC-FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (165 aa), FASTA scores: opt: 266, E(): 5.5e-11,(32.4% identity in 145 aa overlap); Q9ZEP1|LRPA|SCE94.12c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (150 aa), FASTA scores: opt: 249, E(): 6.9e-10,(33.35% identity in 147 aa overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (150 aa), FASTA scores: opt: 261, E(): 1.1e-10, (36.4% identity in 143 aa overlap).	Q7TYT6,A0A1R3Y0U9	No	regulatory proteins			A0A1R3Y0U9				IPR000485,IPR011008,IPR011991,IPR019887,IPR019888	Q7TYT6					Rv2324		Rv2324			
NC_002945.3	Mycobrowser_v4	CDS	2581892	2582278	.	+	0	Mb2358	Mb2358		HYPOTHETICAL PROTEIN	Mb2358, -, len: 128 aa. Equivalent to Rv2331, len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04.	X2BKR9,P0A5G4	No	conserved hypotheticals			P0A5G4					X2BKR9					Rv2331		Rv2331			
NC_002945.3	Mycobrowser_v4	CDS	2582335	2582673	.	+	0	Mb2359	Mb2359		HYPOTHETICAL PROTEIN	Mb2359, -, len: 112 aa. Equivalent to Rv2331A, len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 112 aa overlap). Hypothetical unknown protein.	Q7TYT3,A0A1R3Y0X3	No	conserved hypotheticals			A0A1R3Y0X3					Q7TYT3					Rv2331A		Rv2331A			
NC_002945.3	Mycobrowser_v4	CDS	2574604	2575452	.	-	0	Mb2352c	Mb2352c		CONSERVED HYPOTHETICAL PROTEIN	Mb2352c, -, len: 282 aa. Equivalent to Rv2325c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 282 aa overlap). Conserved hypothetical protein, equivalent to O32970|MLCB22.37c|ML0849 hypothetical protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1405,E(): 1.8e-78, (77.7% identity in 282 aa overlap). Also some similarity to other proteins e.g. Q9Z9J1|YBAF|BH0166 YBAF PROTEIN (BH0166 PROTEIN) (HYPOTHETICAL PROTEIN) from Bacillus halodurans (265 aa), FASTA scores: opt: 288, E(): 2.8e-10, (25.8% identity in 264 aa overlap); P70972|YBAF YBAF PROTEIN (HYPOTHETICAL PROTEIN) from Bacillus subtilis (265 aa), FASTA scores: opt: 259, E(): 1.5e-08, (25.45% identity in 224 aa overlap); AAK34821|SPY2193|Q99X13 Conserved hypothetical protein from Streptococcus pyogenes (266 aa), FASTA scores: opt: 232, E(): 6.5e-07, (25.1% identity in 267 aa overlap); etc.	X2BKB6,P64998,P64998	No	conserved hypotheticals			P64998					X2BKB6,P64998					Rv2325c		Rv2325c			
NC_002945.3	Mycobrowser_v4	CDS	2575449	2577542	.	-	0	Mb2353c	Mb2353c		possible transmembrane atp-binding protein abc transporter	Mb2353c, -, len: 697 aa. Equivalent to Rv2326c,len: 697 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 697 aa overlap). Putative transmembrane ATP-binding protein ABC transporter (see citation below). Equivalent to Q9CCF9|ML0848 ABC TRANSPORTER from Mycobacterium leprae (724 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap) and also to O32971|MLCB22.38c ABC-TYPE TRANSPORTER from Mycobacterium leprae (726 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap). Similar in part to other ABC TRANSPORTERS e.g. Q9WY65|TM0222 from Thermotoga maritima (266 aa),FASTA scores: opt: 407, E(): 4.2e-15, (38.0% identity in 213 aa overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop); and 2 x PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	X2BKR5,P63400,P63400	No	cell wall and cell processes			P63400					X2BKR5,P63400					Rv2326c		Rv2326c			
NC_002945.3	Mycobrowser_v4	CDS	2610221	2610649	.	-	0	Mb2381c	Mb2381c		unknown protein	Mb2381c, -, len: 142 aa. Equivalent to Rv2360c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Hypothetical unknown protein.	Q7TYR5,A0A1R3Y0X8	No	conserved hypotheticals			A0A1R3Y0X8					Q7TYR5					Rv2360c		Rv2360c			
NC_002945.3	Mycobrowser_v4	CDS	2838228	2838647	.	-	0	Mb2581c	Mb2581c		CONSERVED HYPOTHETICAL PROTEIN	Mb2581c, -, len: 139 aa. Equivalent to Rv2551c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, similar to the second part of Q9XAP1|SC10A7.34c PUTATIVE TYPE IV PEPTIDASE from Streptomyces coelicolor (259 aa), FASTA scores: opt: 243,E(): 7.4e-08, (40.95% identity in 144 aa overlap). Also some similarity with other proteins e.g. AAK58497|GSPO GSPO PROTEIN from Acetobacter diazotrophicus (261 aa),FASTA scores: opt: 152, E(): 0.025, (33.35% identity in 135 aa overlap).	Q7TYB4,A0A1R3Y1I8	No	conserved hypotheticals			A0A1R3Y1I8				IPR000045	Q7TYB4					Rv2551c		Rv2551c			
NC_002945.3	Mycobrowser_v4	CDS	2588433	2589401	.	+	0	Mb2364	Mb2364		HYPOTHETICAL PROTEIN	Mb2364, -, len: 322 aa. Equivalent to Rv2336, len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 322 aa overlap). Hypothetical unknown protein (see second citation below).	Q7TYS9,A0A1R3Y142	No	conserved hypotheticals			A0A1R3Y142					Q7TYS9					Rv2336		Rv2336			
NC_002945.3	Mycobrowser_v4	CDS	2589465	2590583	.	-	0	Mb2365c	Mb2365c		HYPOTHETICAL PROTEIN	Mb2365c, -, len: 372 aa. Equivalent to Rv2337c,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 372 aa overlap). Hypothetical unknown protein, sharing some similarity with Q9RI33|SCJ12.27c HYPOTHETICAL 37.2 KDA PROTEIN from Streptomyces coelicolor (335 aa), BLAST scores: 134 AND 46, (28% AND 33% identity,52% AND 44% positive); FASTA scores: opt: 176, E(): 0.00042, (31.95% identity in 355 aa overlap).	Q7TYS8,A0A1R3Y1A9	No	conserved hypotheticals			A0A1R3Y1A9					Q7TYS8					Rv2337c		Rv2337c			
NC_002945.3	Mycobrowser_v4	CDS	2597869	2598126	.	+	0	Mb2371	Mb2371		CONSERVED HYPOTHETICAL PROTEIN	Mb2371, -, len: 85 aa. Equivalent to Rv2342, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, highly similar to Q9CCG1|ML0834 HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 392, E(): 2.9e-20, (78.2% identity in 78 aa overlap). N-terminus highly similar to N-terminal part of Q9L085|SCC24.32 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (108 aa), FASTA scores: opt: 122,E(): 0.077, (39.15% identity in 46 aa overlap).	Q7TYS2,A0A1R3Y0W0	No	conserved hypotheticals			A0A1R3Y0W0					Q7TYS2					Rv2342		Rv2342			
NC_002945.3	Mycobrowser_v4	CDS	4171669	4172034	.	+	0	Mb3818	Mb3818		gtra family protein	Mb3818, -, len: 121 aa. Equivalent to Rv3789, len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 121 aa overlap). Conserved hypothetical protein, equivalent to Q9CDA3|ML0110 HYPOTHETICAL 13.9 KDA PROTEIN from Mycobacterium leprae (123 aa) FASTA scores: opt: 587, E(): 7.3e-34, (72.95% identity in 122 aa overlap). Equivalent to AAK48262 from Mycobacterium tuberculosis strain CDC1551 (142 aa) but shorter 21 aa.	X2BPU5,P64293,P64293	No	cell wall and cell processes			P64293					X2BPU5,P64293					Rv3789		Rv3789			
NC_002945.3	Mycobrowser_v4	CDS	2601418	2603400	.	+	0	Mb2374	Mb2374		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2374, -, len: 660 aa. Equivalent to Rv2345, len: 660 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 660 aa overlap). Possible conserved transmembrane protein, with hydrophobic stretch at N-terminal end around position 180. Similar to O52198 HYPOTHETICAL 21.2 KDA PROTEIN (FRAGMENT) from Mycobacterium smegmatis (195 aa), FASTA scores: opt: 589,E(): 1.5e-23; (47.2% identity in 195 aa overlap).	Q7TYS1,A0A1R3Y161	No	cell wall and cell processes			A0A1R3Y161				IPR007621	Q7TYS1					Rv2345		Rv2345			
NC_002945.3	Mycobrowser_v4	CDS	2610649	2611539	.	-	0	Mb2382c	Mb2382c		LONG (C50) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-DECAPRENYL DIPHOSPHATE SYNTHASE)	Mb2382c, -, len: 296 aa. Equivalent to Rv2361c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Long (C50) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.-) (see citation below), equivalent to UPPS_MYCLE|ML0634|B1937_F2_65|P38119 UNDECAPRENYL PYROPHOSPHATE SYNTHETASE from Mycobacterium leprae (296 aa), FASTA scores: opt: 1789, E(): 1.8e-97, (86.5% identity in 296 aa overlap). Also highly similar to others e.g. UPPS|Q9L2H4 UNDECAPRENYL PYROPHOSPHATE SYNTHETASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 1098, E(): 8.2e-60, (63.5% identity in 247 aa overlap); Q55482|UPPS_SYNY3|SLL0506 from Synechocystis sp. strain PCC 6803 (249 aa), FASTA scores: opt: 686, E(): 4.2e-33,(46.4% identity in 235 aa overlap); O67291|UPPS_AQUAE|AQ_1248 from Aquifex aeolicus (231 aa),FASTA scores: opt: 684, E(): 5.2e-33, (46.3% identity in 229 aa overlap); etc. Also similar to Rv1086|MTV017.39 from Mycobacterium tuberculosis. Contains PS01066 Hypothetical YBR002c family signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY. Note that previously known as uppS.	X2BKF4,P60478,P60478	No	cell wall and cell processes			P60478					X2BKF4,P60478					Rv2361c		Rv2361c			
NC_002945.3	Mycobrowser_v4	CDS	2844524	2845198	.	+	0	Mb2587	Mb2587		conserved protein	Mb2587, -, len: 224 aa. Equivalent to Rv2557, len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Conserved hypothetical protein, highly similar only to upstream ORF Q50740|MTCY9C4.10c|Rv2558|MT2635 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (236 aa), FASTA scores: opt: 1007, E(): 6.9e-60, (69.2% identity in 224 aa overlap).	X2BLP8,P65004	No	conserved hypotheticals			P65004					X2BLP8					Rv2557		Rv2557			
NC_002945.3	Mycobrowser_v4	CDS	2685981	2686361	.	-	0	Mb2443c	Mb2443c		CONSERVED HYPOTHETICAL PROTEIN	Mb2443c, -, len: 126 aa. Equivalent to Rv2420c,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Conserved hypothetical protein, equivalent to Q9CBZ9|ML1453 HYPOTHETICAL PROTEIN from Mycobacterium leprae (129 aa),FASTA scores: opt: 681, E(): 1.6e-38, (87.0% identity in 123 aa overlap). Also highly similar to Q9RDK9|SCC123.15c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (148 aa), FASTA scores: opt: 447, E(): 5.8e-23, (52.7% identity in 129 aa overlap); and similar to others e.g. P54457|YQEL_BACSU HYPOTHETICAL PROTEIN from Bacillus subtilis (118 aa), FASTA scores: opt: 318, E(): 1.8e-14,(37.3% identity in 110 aa overlap); Q9KD89|BH1328 HYPOTHETICAL PROTEIN from Bacillus halodurans (117 aa),FASTA scores: opt: 296, E(): 5.1e-13, (37.6% identity in 109 aa overlap); etc.	Q7TYM2,A0A1R3Y150	No	conserved hypotheticals			A0A1R3Y150				IPR004394,IPR025656	Q7TYM2					Rv2420c		Rv2420c			
NC_002945.3	Mycobrowser_v4	CDS	2618017	2618319	.	-	0	Mb2390c	Mb2390c		HYPOTHETICAL PROTEIN	Mb2390c, -, len: 100 aa. Equivalent to Rv2369c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Hypothetical unknown protein.	Q7TYR3,A0A1R3Y116	No	conserved hypotheticals			A0A1R3Y116					Q7TYR3					Rv2369c		Rv2369c			
NC_002945.3	Mycobrowser_v4	CDS	2614818	2615159	.	-	0	Mb2386c	Mb2386c		CONSERVED HYPOTHETICAL PROTEIN	Mb2386c, -, len: 113 aa. Equivalent to Rv2365c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Conserved hypothetical protein, highly similar to Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein from Mycobacterium leprae (108 aa), FASTA scores: opt: 426, E(): 1.4e-18, (67.9% identity in 106 aa overlap). Also highly similar to Q9RDF3|SCC77.05 from Streptomyces coelicolor (132 aa), FASTA scores: opt: 254, E(): 1.9e-18,(53.1% identity in 96 aa overlap). Equivalent to AAK46728 from Mycobacterium tuberculosis strain CDC1551 (93 aa) but longer 20 aa.	Q7TYR4	No	conserved hypotheticals							IPR016193	Q7TYR4	A0A1R3Y0Z2				Rv2365c		Rv2365c			
NC_002945.3	Mycobrowser_v4	CDS	2615131	2616438	.	-	0	Mb2387c	Mb2387c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2387c, -, len: 435 aa. Equivalent to Rv2366c,len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 435 aa overlap). Probable conserved transmembrane protein, highly similar to Q9L2L3|SCC117.07 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (358 aa), FASTA scores: opt: 1159, E(): 5.5e-64, (53.0% identity in 353 aa overlap); ans similar to hypothetical proteins and hemolysin-related proteins e.g. Q9HN02|HLP|VNG2308G HEMOLYSIN PROTEIN from Halobacterium sp. strain NRC-1 (457 aa), FASTA scores: opt: 623, E(): 6.2e-31, (28.4% identity in 433 aa overlap); etc. Potential transmembrane protein with 2 CBS domains. BELONGS TO THE UPF0053 FAMILY.	X2BKF9,P67131	No	cell wall and cell processes								X2BKF9,P67131	P67131				Rv2366c		Rv2366c			
NC_002945.3	Mycobrowser_v4	CDS	2616435	2616983	.	-	0	Mb2388c	Mb2388c		conserved hypothetical protein	Mb2388c, -, len: 182 aa. Equivalent to Rv2367c,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Conserved hypothetical protein, equivalent to Q49752|YN67_MYCLE|ML0628|B1937_F1_21 HYPOTHETICAL 19.8 KDA PROTEIN from Mycobacterium leprae (178 aa), FASTA scores: opt: 1051, E(): 2e-59, (89.1% identity in 175 aa overlap). Also highly similar to others e.g. Q9L2L4|SCC117.06 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (165 aa), FASTA scores: opt: 599, E(): 6e-31,(56.5% identity in 154 aa overlap); Q9KD56|BH1363 HYPOTHETICAL PROTEIN from Bacillus halodurans (159 aa),FASTA scores: opt: 311, E(): 8.3e-13, (45.05% identity in 111 aa overlap); etc.	X2BKV6,P67135	No	conserved hypotheticals								X2BKV6,P67135	P67135				Rv2367c		Rv2367c			
NC_002945.3	Mycobrowser_v4	CDS	2618316	2619629	.	-	0	Mb2391c	Mb2391c		CONSERVED HYPOTHETICAL PROTEIN	Mb2391c, -, len: 437 aa. Equivalent to Rv2370c,len: 437 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 437 aa overlap). Conserved hypothetical protein, member of family proteins from Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1943, E(): 9.4e-115, (69.9% identity in 409 aa overlap); Rv1194c|MTCI364.06c; etc. Also similar to AAK45764|MT1500 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (432 aa), FASTA scores: opt: 1934, E(): 9.4e-115, (69.9% identity in 409 aa overlap).	Q7TYR2	No	conserved hypotheticals							IPR025736	Q7TYR2	A0A1R3Y0Y6				Rv2370c		Rv2370c			
NC_002945.3	Mycobrowser_v4	CDS	2620108	2620896	.	-	0	Mb2393c	Mb2393c		CONSERVED HYPOTHETICAL PROTEIN	Mb2393c, -, len: 262 aa. Equivalent to Rv2372c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Conserved hypothetical protein, equivalent to Q9CCN1|ML0626 HYPOTHETICAL PROTEIN from Mycobacterium leprae (257 aa),FASTA scores: opt: 1277, E(): 3e-71, (77.25% identity in 255 aa overlap). Also highly similar to others e.g. Q9RDD9|SDRD HYPOTHETICAL 26.1 KDA PROTEIN from Streptomyces coelicolor (249 aa), FASTA scores: opt: 624,E(): 3.2e-31, (45.05% identity in 253 aa overlap); P54461|YQEU_BACSU hypothetical 28.8 kd protein from Bacillus subtilis (256 aa), FASTA scores: opt: 375, E(): 6e-16, (32.5% identity in 234 aa overlap); etc. C-terminal half highly similar to Q49763|B1937_F2_57 from Mycobacterium leprae (128 aa), FASTA scores: opt: 577,E(): 1.4e-28, (75.8% identity in 124 aa overlap). BELONGS TO THE UPF0088 FAMILY.	X2BKW0,P67203	No	conserved hypotheticals								X2BKW0,P67203	P67203				Rv2372c		Rv2372c			
NC_002945.3	Mycobrowser_v4	CDS	2490838	2491428	.	-	0	Mb2264c	Mb2264c		unknown protein	Mb2264c, len: 196 aa. Equivalent to Rv2240c len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 196 aa overlap). Unknown protein. Start changed since first submission (-69 aa).	X2BKI1,A0A1R3Y1D4	No	conserved hypotheticals			A0A1R3Y1D4					X2BKI1					Rv2240c		Rv2240c			
NC_002945.3	Mycobrowser_v4	CDS	4086939	4087259	.	-	0	Mb3733c	Mb3733c		CONSERVED HYPOTHETICAL PROLINE RICH PROTEIN	Mb3733c, -, len: 106 aa. Equivalent to Rv3706c,len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 106 aa overlap). Conserved ypothetical pro-rich protein, only similar to upstream ORF Rv3705A (129 aa), and AAK48176|MT3808.1 HYPOTHETICAL 13.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (129 aa), FASTA scores: opt: 245, E(): 4.4e-06, (40.7% identity in 113 aa overlap).	Q7TVV8	No	conserved hypotheticals								Q7TVV8	A0A1R3Y4Z6				Rv3706c		Rv3706c			
NC_002945.3	Mycobrowser_v4	CDS	2648529	2648738	.	+	0	Mb2407A	Mb2407A		HYPOTHETICAL PROTEIN	Mb2407A, -, len: 69 aa. Equivalent to MT2455 from Mycobacterium tuberculosis strain CDC1551, (100% identity in 69 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Mb2407A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BKY3	No									X2BKY3	A0A1R3Y121									
NC_002945.3	Mycobrowser_v4	CDS	2648836	2650089	.	+	0	Mb2408	Mb2408		conserved protein	Mb2408, -, len: 417 aa. Equivalent to Rv2387, len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 417 aa overlap). Conserved hypothetical protein, showing some similarities with others e.g. Q9K663|BH3869 HYPOTHETICAL PROTEIN from Bacillus halodurans (337 aa), FASTA scores: opt: 343, E(): 4.8e-14, (29.0% identity in 400 aa overlap); AAK25471|CC3509 HYPOTHETICAL PROTEIN from Caulobacter crescentus (365 aa), FASTA scores: opt: 282, E(): 3.2e-10,(32.6% identity in 399 aa overlap); P73953|SLR1512 [D90911_21] CONSERVED HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC6803 (374 aa), FASTA scores: opt: 230, E(): 5.5e-07; (24.75% identity in 408 aa overlap); etc. Contains PS00213 Lipocalin signature.	Q7TYQ0	No	conserved hypotheticals							IPR010293	Q7TYQ0	A0A1R3Y132				Rv2387		Rv2387			
NC_002945.3	Mycobrowser_v4	CDS	2718476	2719735	.	-	0	Mb2476c	Mb2476c		conserved protein	Mb2476c, -, len: 419 aa. Equivalent to Rv2449c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 419 aa overlap). Conserved hypothetical protein, highly similar to hypothetical proteins e.g. P95139|Rv2953|MTCY349.37c from M. tuberculosis (418 aa), FASTA scores: opt: 1829, E(): 4.7e-103, (67.3% identity in 419 aa overlap); AAK47353|MT3027 from Mycobacterium tuberculosis strain CDC1551 (418 aa), FASTA score: opt: 1829, E(): 4.7e-103,(67.3 identity in 419 aa overlap); Q9CD87|ML0129 from Mycobacterium leprae (418 aa), FASTA scores: opt: 1727,E(): 6.8e-97, (65.45% identity in 414 aa overlap); etc.	Q7TYK0	No	conserved hypotheticals							IPR005097,IPR016040	Q7TYK0	A0A1R3Y194				Rv2449c		Rv2449c			
NC_002945.3	Mycobrowser_v4	CDS	2651780	2652337	.	-	0	Mb2411c	Mb2411c		CONSERVED HYPOTHETICAL PROTEIN	Mb2411c, -, len: 185 aa. Equivalent to Rv2390c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 185 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis proteins Q11032|YD62_MYCTU|MTCY02B10.26c|Rv1362c hypothetical 23.5 kd protein (220 aa), FASTA scores: opt: 223, E(): 2.1e-07, (27.4% identity in 190 aa overlap); and Q11033|YD63_MYCTU|MTCY02B10.27c|Rv1363c hypothetical 28.3 kd protein (261 aa), FASTA scores: opt: 238, E(): 2.7e-08,(27.6% identity in 163 aa overlap).	Q7TYP7	No	conserved hypotheticals								Q7TYP7	A0A1R3Y390				Rv2390c		Rv2390c			
NC_002945.3	Mycobrowser_v4	CDS	2938577	2938831	.	+	0	Mb2682	Mb2682		HYPOTHETICAL PROTEIN	Mb2682, -, len: 84 aa. Equivalent to Rv2664, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Hypothetical protein. Some weak similarity to nearby P71964|Rv2667|clpX'|MT2741|MTCY441.36 POSSIBLE ATP-DEPENDENT PROTEASE ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (252 aa), FASTA scores: opt: 134, E(): 0.027, (31.15% identity in 77 aa overlap).	Q7TY59	No	conserved hypotheticals								Q7TY59	A0A1R3Y1U5				Rv2664		Rv2664			
NC_002945.3	Mycobrowser_v4	CDS	2658143	2658583	.	+	0	Mb2416	Mb2416		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [FIRST PART]	Mb2416, -, len: 146 aa. Equivalent to 5' end of Rv2395, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 44 aa overlap). Probable conserved integral membrane protein, similar to AAK24613|CC2646 OLIGOPEPTIDE TRANSPORTER/OPT FAMILY PROTEIN from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts,Mb2416 and Mb2417.	Q7TYP3	No								IPR004813	Q7TYP3	A0A1R3Y128									
NC_002945.3	Mycobrowser_v4	CDS	2672078	2672506	.	-	0	Mb2429c	Mb2429c		conserved protein	Mb2429c, -, len: 142 aa. Equivalent to Rv2406c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein. C-terminal region is identical with many CBS DOMAIN PROTEIN e.g. AAK46774|MT2478 CBS DOMAIN PROTEIN from Mycobacterium tuberculosis strain CDC1551 (aa 47-142), FASTA scores: opt: 594, E(): 1.9e-30, (98.97% identity in 97 aa overlap); etc. Also similar to other hypothetical proteins e.g. AAK24594|CC2626 CBS DOMAIN PROTEIN from Caulobacter crescentus (157 aa), FASTA scores: opt: 377, E(): 8.3e-17, (42.55% identity in 141 aa overlap); BAB47826|MLR0188 from Rhizobium loti; etc.	Q7TYN2	No	conserved hypotheticals							IPR000644	Q7TYN2	A0A1R3Y3B0				Rv2406c		Rv2406c			
NC_002945.3	Mycobrowser_v4	CDS	2658597	2660147	.	+	0	Mb2417	Mb2417		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [SECOND PART]	Mb2417, -, len: 516 aa. Equivalent to 3' end of Rv2395, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 516 aa overlap). Probable conserved integral membrane protein, similar to AAK24613|CC2646 OLIGOPEPTIDE TRANSPORTER/OPT FAMILY PROTEIN from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts,Mb2416 and Mb2417.	Q7TYP2	No								IPR004813,IPR004814	Q7TYP2	A0A1R3Y129									
NC_002945.3	Mycobrowser_v4	CDS	2674678	2675517	.	-	0	Mb2432c	Mb2432c		conserved protein	Mb2432c, -, len: 279 aa. Equivalent to Rv2409c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Conserved hypothetical protein, equivalent to Q49757|YP69_MYCLE|G466976|B1937_F2_39 HYPOTHETICAL PROTEIN from Mycobacterium leprae (279 aa), FASTA scores: opt: 1564, E(): 4.6e-95, (82.1% identity in 279 aa overlap). Also similar to others e.g. Q9RSX6|DR1993 from Deinococcus radiodurans (274 aa), FASTA scores: opt: 494, E(): 4e-25,(35.1% identity in 282 aa overlap); BAB49898|Mll2875 from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: opt: 382, E(): 8.9e-18, (29.75% identity in 269 aa overlap); Q9I305|PA1732 from Pseudomonas aeruginosa (266 aa), FASTA scores: opt: 326, E(): 3.7e-14, (31.25% identity in 275 aa overlap); etc. Also similar to Rv2569c|MTCY227.32 from Mycobacterium tuberculosis.	Q7TYM9	No	conserved hypotheticals							IPR002931,IPR013589	Q7TYM9	A0A1R3Y1H6				Rv2409c		Rv2409c			
NC_002945.3	Mycobrowser_v4	CDS	2665797	2666126	.	+	0	Mb2423	Mb2423		HYPOTHETICAL PROTEIN	Mb2423, -, len: 109 aa. Equivalent to Rv2401, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein. Equivalent to AAK46768 from Mycobacterium tuberculosis strain CDC1551 (134 aa) but shorter 25 aa. N-terminus extended since first submission (previously 72 aa).	Q7TYN7	No	conserved hypotheticals								Q7TYN7	A0A1R3Y130				Rv2401		Rv2401			
NC_002945.3	Mycobrowser_v4	CDS	2666111	2666314	.	-	0	Mb2424c	Mb2424c		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb2424c, -, len: 67 aa. Equivalent to Rv2401A, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Possible conserved membrane protein, highly similar, but with 29 aa shorter,to ML0614|AL583919_34|Q49760 from Mycobacterium leprae (95 aa), FASTA scores: opt: 297, E(): 3.6e-15, (67.7% identity in 65 aa overlap). Has hydrophobic stretch.	Q7TYN6	No	cell wall and cell processes								Q7TYN6	A0A1R3Y141				Rv2401A		Rv2401A			
NC_002945.3	Mycobrowser_v4	CDS	2666442	2668526	.	+	0	Mb2425	Mb2425		conserved protein	Mb2425, -, len: 694 aa. Equivalent to hypothetical protein from Mycobacterium tuberculosis strain Erdman ATCC 35801 (99% identity with 692 aa overlap). Identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Conserved hypothetical protein, highly similar to others e.g. 9X8C4|SCE36.11c CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) from Streptomyces coelicolor (612 aa). Contains Glycosyl hydrolases family 15 superfamily domain, a glucoamylase and related glycosyl hydrolases multi-domain and a oligosaccharide amylase multi-domain. Mb2425 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BL18	No									X2BL18	A0A1R3Y140									
NC_002945.3	Mycobrowser_v4	CDS	2675517	2676494	.	-	0	Mb2433c	Mb2433c		conserved protein	Mb2433c, -, len: 325 aa. Equivalent to Rv2410c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 325 aa overlap). Conserved hypothetical protein, equivalent to Q49770|CAC30114|ML0606 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (325 aa), FASTA scores: opt: 1928, E(): 3.5e-117, (90.75% identity in 325 aa overlap). Also some similarity with other hypothetical proteins e.g. Q9RST2|DR2041 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (316 aa), FASTA scores: opt: 329, E(): 5.3e-14, (32.4% identity in 318 aa overlap); C-terminus of Q9HUN7|PA4927 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (830 aa),FASTA scores: opt: 297, E(): 1.5e-11, (27.6% identity in 315 aa overlap); etc.	Q7TYM8	No	conserved hypotheticals							IPR007296	Q7TYM8	A0A1R3Y139				Rv2410c		Rv2410c			
NC_002945.3	Mycobrowser_v4	CDS	2671338	2671907	.	+	0	Mb2428	Mb2428		conserved protein	Mb2428, -, len: 189 aa. Equivalent to Rv2405, len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 189 aa overlap). Conserved hypothetical protein, identical (but N-terminus longer 40 residues) to AAK46773|MT2477 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551. Also highly similar, but N-terminus longer 38 residues, to Q9RD03|SCCM1.41 HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 451,E(): 2e-22, (48.7% identity in 154 aa overlap). Shows also similarity with hypothetical proteins from other species.	Q7TYN3	No	conserved hypotheticals							IPR003477,IPR011067	Q7TYN3	A0A1R3Y120				Rv2405		Rv2405			
NC_002945.3	Mycobrowser_v4	CDS	2678535	2679485	.	-	0	Mb2436c	Mb2436c		CONSERVED HYPOTHETICAL PROTEIN	Mb2436c, -, len: 316 aa. Equivalent to Rv2413c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 316 aa overlap). Conserved hypothetical protein, highly similar to O33133|MLCL536.07c|ML0603|Q49756|G466975|B1937_F2_36 hypothetical 39.1 KDA protein from Mycobacterium leprae (389 aa), FASTA scores: opt: 1683, E(): 1.8e-88, (83.9% identity in 316 aa overlap). ML0603 is a putative lipoprotein with an N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site that is not present in Rv2413c as this seems to be 73 aa shorter. Also some similarity with various proteins from other organisms e.g. Q9RDM2|SCC123.02c PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 792,E(): 6.1e-38, (42.4% identity in 316 aa overlap); Q9HX31|HOLA|PA3989 DNA POLYMERASE III, DELTA SUBUNIT from Pseudomonas aeruginosa (345 aa), FASTA scores: opt: 173,E(): 0.0084, (25.4% identity in 307 aa overlap); etc.	Q7TYM7	No	conserved hypotheticals							IPR008921,IPR010372,IPR027417	Q7TYM7	A0A1R3Y156				Rv2413c		Rv2413c			
NC_002945.3	Mycobrowser_v4	CDS	2672766	2673608	.	+	0	Mb2430	Mb2430		conserved hypothetical protein	Mb2430, -, len: 280 aa. Equivalent to Rv2407, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(97.5% identity in 280 aa overlap). Conserved hypothetical protein, highly similar (but longer at N-terminus) to AAK46775|MT2479 putative arylsulfatase from Mycobacterium tuberculosis strain CDC1551 (224 aa) FASTA scores: opt: 1433, E(): 2.5e-81, (96.43% identity in 224 aa overlap); O33130|MLCL536.01 HYPOTHETICAL PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 658, E(): 1.5e-33,(56.75% identity in 215 aa overlap). Also similar to AAK23160|CC1176 Metallo-beta-lactamase family protein from Caulobacter crescentus (317 aa), FASTA scores: opt: 286,E(): 1.8e-10, (33% identity in 291 aa overlap). And similar to other hypothetical proteins eg Q49744|B1937_C1_163 HYPOTHETICAL 22.6 KDA PROTEIN (PRECURSOR) from Mycobacterium leprae (211 aa), FASTA scores: opt: 623, E(): 2.1e-31, (56.3% identity in 206 aa overlap); O27859|MTH1831 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (307 aa), FASTA scores: opt: 268, E(): 2.3e-09, (28.35% identity in 307 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 21 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (280 aa versus 273 aa).	X2BL26,Q7TYN1	No	conserved hypotheticals								X2BL26,Q7TYN1	Q7TYN1				Rv2407		Rv2407			
NC_002945.3	Mycobrowser_v4	CDS	2676494	2678149	.	-	0	Mb2434c	Mb2434c		CONSERVED HYPOTHETICAL PROTEIN	Mb2434c, -, len: 551 aa. Equivalent to Rv2411c,len: 551 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 551 aa overlap). Hypothetical protein,highly similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 HYPOTHETICAL 61.8 KDA PROTEIN from Mycobacterium leprae (561 aa), FASTA scores, opt: 3163, E(): 4.1e-178, (87.35% identity in 554 aa overlap). Also highly similar, except in N-terminus, to others e.g. Q55587|Y335_SYNY3|SLL0335 HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC 6803 (481 aa), FASTA scores: opt: 1620, E(): 1.2e-87,(52.8% identity in 468 aa overlap); Q9I307|PA1730 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (470 aa),FASTA scores: opt: 1574, E(): 5.8e-85, (52.7% identity in 467 aa overlap); Q9RST1|DR2042 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (655 aa), FASTA scores: opt: 1561, E(): 4.4e-84, (53.3% identity in 467 aa overlap); etc.	X2BKL7	No	conserved hypotheticals								X2BKL7	P65002				Rv2411c		Rv2411c			
NC_002945.3	Mycobrowser_v4	CDS	2679490	2681061	.	-	0	Mb2437c	Mb2437c		CONSERVED HYPOTHETICAL PROTEIN	Mb2437c, -, len: 523 aa. Similar to Rv2414c, len: 514 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 483 aa overlap). Conserved hypothetical protein, showing some similarity with COME OPERON PROTEINS 3 (COMEC OR COME3) e.g. Q9RTB1|DR1854 PUTATIVE COMPETENCE PROTEIN COMEC/REC2 from Deinococcus radiodurans (755 aa), FASTA scores: opt: 311, E(): 8.2e-11, (27.3% identity in 538 aa overlap); P73100|COME|SLL1929 COME PROTEIN from Synechocystis sp. strain PCC 6803 (709 aa), FASTA scores: opt: 302, E(): 2.6e-10, (26.3% identity in 323 aa overlap) (no similarity on N-terminus); P39695|CME3_BACSU COME OPERON PROTEIN 3 from Bacillus subtilis (776 aa), FASTA scores: opt: 273,E(): 1.4e-08, (25.2% identity in 282 aa overlap) (no similarity on N-terminus); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-t) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (523 aa versus 514 aa).	Q7TYM6	No								IPR004477	Q7TYM6	A0A1R3Y162									
NC_002945.3	Mycobrowser_v4	CDS	2923230	2924354	.	+	0	Mb2662	Mb2662		conserved protein	Mb2662, -, len: 374 aa. Equivalent to Rv2629, len: 374 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 374 aa overlap). Conserved hypothetical protein, similar to Q9ZC00|SC1E6.22c HYPOTHETICAL 40.7 KDA PROTEIN from Streptomyces coelicolor (373 aa), FASTA scores: opt: 425, E(): 2.5e-18, (30.2% identity in 371 aa overlap).	Q7TY69	No	conserved hypotheticals								Q7TY69	A0A1R3Y1S3				Rv2629		Rv2629			
NC_002945.3	Mycobrowser_v4	CDS	2824650	2825051	.	-	0	Mb2561c	Mb2561c		HYPOTHETICAL PROTEIN	Mb2561c, -, len: 133 aa. Equivalent to Rv2532c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Hypothetical unknown protein, equivalent to AAK46918 from Mycobacterium tuberculosis strain CDC1551 but shorter 157 aa.	Q7TYC9	No	conserved hypotheticals								Q7TYC9	A0A1R3Y1W4				Rv2532c		Rv2532c			
NC_002945.3	Mycobrowser_v4	CDS	2681076	2681969	.	-	0	Mb2438c	Mb2438c		CONSERVED HYPOTHETICAL PROTEIN	Mb2438c, -, len: 297 aa. Equivalent to Rv2415c,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 297 aa overlap). Hypothetical protein,with some similarity in C-terminal part to comE operon proteins 1 e.g. Q9EU10|COME|COME4|COME1|COME2|COME3 COME PROTEIN (a competence protein with DNA-binding activity) from Neisseria gonorrhoeae (99 aa), FASTA scores: opt: 190, E(): 0.0032, (49.2% identity in 61 aa overlap); Q9JYB8|NMB1657 from Neisseria meningitidis (205 aa) FASTA scores: opt: 191, E(): 0.0052, (49.2% identity in 61 aa overlap); CME1_BACSU|P39694 come operon protein 1 from Bacillus subtilis (205 aa), FASTA scores, opt: 181, E(): 0.017 (29.8% identity in 218 aa overlap); etc.	Q7TYM5	No	conserved hypotheticals							IPR003583,IPR010994,IPR019554	Q7TYM5	A0A1R3Y127				Rv2415c		Rv2415c			
NC_002945.3	Mycobrowser_v4	CDS	2683657	2684499	.	-	0	Mb2440c	Mb2440c		conserved protein	Mb2440c, -, len: 280 aa. Equivalent to Rv2417c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to Q9RDL7|SCC123.07c HYPOTHETICAL 29.2 KDA PROTEIN from Streptomyces coelicolor (281 aa), FASTA scores: opt: 579, E(): 3.6e-27, (38.3% identity in 274 aa overlap). Also some similarity with DEGV proteins or hypothetical proteins from other organisms, e.g. Q9RSY3|DR1986 from Deinococcus radiodurans (281 aa), FASTA scores: opt: 393, E(): 3.4e-16, (31.0% identity in 280 aa overlap); P32436|DEGV_BACSU from Bacillus subtilis (281 aa), FASTA scores: opt: 365, E(): 1.5e-14, (27.8% identity in 284 aa overlap); BAB41937|BAB46307|SA0704|SAV0749 Conserved hypothetical protein from Staphylococcus aureus strain Mu50 and N315 (288 aa), FASTA scores: opt: 371, E(): 7e-15, (28.85% identity in 281 aa overlap); etc.	X2BL43,P67369	No	conserved hypotheticals								X2BL43,P67369	P67369				Rv2417c		Rv2417c			
NC_002945.3	Mycobrowser_v4	CDS	2684580	2685323	.	-	0	Mb2441c	Mb2441c		unknown protein	Mb2441c, -, len: 247 aa. Equivalent to Rv2418c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Hypothetical unknown protein.	Q7TYM4	No	conserved hypotheticals							IPR013831	Q7TYM4	A0A1R3Y1D0				Rv2418c		Rv2418c			
NC_002945.3	Mycobrowser_v4	CDS	2688961	2689653	.	-	0	Mb2447c	Mb2447c		PROBABLE TRANSPOSASE [SECOND PART]	Mb2447c, -, len: 230 aa. Equivalent to 3' end of Rv2424c, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 230 aa overlap). Probable transposase for IS1558, similar to IS element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 1491, E(): 6.2e-87, (98.6% identity in 221 aa overlap); P19780|YIS1_STRCO HYPOTHETICAL INSERTION ELEMENT IS110 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 203, E(): 1.7e-05; (27.3% identity in 238 aa overlap); etc. Contains PS01159 WW/rsp5/WWP domain signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts, Mb2447c and Mb2448c.	Q7TYL8	No								IPR003346	Q7TYL8	A0A1R3Y171									
NC_002945.3	Mycobrowser_v4	CDS	2689667	2689960	.	-	0	Mb2448c	Mb2448c		PROBABLE TRANSPOSASE [FIRST PART]	Mb2448c, -, len: 97 aa. Similar to 5' end of Rv2424c, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 67 aa overlap). Probable transposase for IS1558, similar to IS element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 1491, E(): 6.2e-87, (98.6% identity in 221 aa overlap); P19780|YIS1_STRCO HYPOTHETICAL INSERTION ELEMENT IS110 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 203, E(): 1.7e-05; (27.3% identity in 238 aa overlap); etc. Contains PS01159 WW/rsp5/WWP domain signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts, Mb2447c and Mb2448c.	Q7TYL7	No								IPR002525	Q7TYL7	A0A1R3Y137									
NC_002945.3	Mycobrowser_v4	CDS	2690049	2691491	.	-	0	Mb2449c	Mb2449c		CONSERVED HYPOTHETICAL PROTEIN	Mb2449c, -, len: 480 aa. Equivalent to Rv2425c,len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Hypothetical protein; C-terminal half shares similarity to other unknown conserved proteins e.g. Q53065 HYPOTHETICAL 24.3 KDA PROTEIN from Rhodococcus erythropolis (219 aa), FASTA scores: opt: 398, E(): 9.9e-17, (34.15% identity in 202 aa overlap); C-terminus of O27843|MTH1815 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (346 aa),FASTA scores: opt: 341, E(): 3.7e-13, (31.35% identity in 233 aa overlap); etc.	Q7TYL6	No	conserved hypotheticals							IPR002035,IPR008912,IPR011195	Q7TYL6	A0A1R3Y3C9				Rv2425c		Rv2425c			
NC_002945.3	Mycobrowser_v4	CDS	2691491	2692366	.	-	0	Mb2450c	Mb2450c		CONSERVED HYPOTHETICAL PROTEIN	Mb2450c, -, len: 291 aa. Equivalent to Rv2426c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 291 aa overlap). Conserved hypothetical protein, highly similar to others e.g. Q51326|ORF4 from Pseudomonas carboxydovorans (295 aa), FASTA scores: opt: 853, E(): 3.7e-43, (48.75% identity in 277 aa overlap); BAB47746|MLR0088 from Rhizobium loti (309 aa), FASTA scores: opt :809, E(): 1.5e-40, (46.5% identity in 291 aa overlap); Q9Y9R8|APE2220 from Aeropyrum pernix (297 aa),FASTA scores: opt: 763, E(): 7.4e-38, (47.1% identity in 261 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TYL5	No	conserved hypotheticals							IPR003593,IPR011704,IPR027417	Q7TYL5	A0A1R3Y1Z5				Rv2426c		Rv2426c			
NC_002945.3	Mycobrowser_v4	CDS	4029078	4030115	.	+	0	Mb3675	Mb3675		CONSERVED HYPOTHETICAL PROTEIN	Mb3675, -, len: 345 aa. Equivalent to Rv3651, len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 345 aa overlap). Hypothetical protein,with some similarity to Q9ZHK1 HYPOTHETICAL 36.5 KDA PROTEIN from Rhodococcus sp. X309 (329 aa) FASTA scores: opt: 332, E(): 3.4e-13, (27.4% identity in 321 aa overlap).	Q7TW12	No	conserved hypotheticals								Q7TW12	A0A1R3Y4T0				Rv3651		Rv3651			
NC_002945.3	Mycobrowser_v4	CDS	2696600	2697010	.	-	0	Mb2458c	Mb2458c		HYPOTHETICAL PROTEIN	Mb2458c, -, len: 136 aa. Equivalent to Rv2432c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Hypothetical unknown protein.	Q7TYL2	No	conserved hypotheticals								Q7TYL2	A0A1R3Y148				Rv2432c		Rv2432c			
NC_002945.3	Mycobrowser_v4	CDS	2697007	2697297	.	-	0	Mb2459c	Mb2459c		HYPOTHETICAL PROTEIN	Mb2459c, -, len: 96 aa. Equivalent to Rv2433c, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Hypothetical unknown protein.	Q7TYL1	No	conserved hypotheticals								Q7TYL1	A0A1R3Y3D5				Rv2433c		Rv2433c			
NC_002945.3	Mycobrowser_v4	CDS	2698720	2700912	.	-	0	Mb2461c	Mb2461c		probable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-)	Mb2461c, -, len: 730 aa. Equivalent to Rv2435c,len: 730 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 730 aa overlap). Probably a cyclase (adenylyl- or guanylyl-cyclase; EC 4.6.1.1 or 4.6.1.2 respectively); C-terminal domain (aa 500-730) similar to domain at C-terminus of a series of adenylate/guanylate cyclases (EC 4.6.-.-) e.g. O30820|CYA AAK45931|MT1661 from Mycobacterium tuberculosis (443 aa) FASTA scores: opt: 446, E(): 1.3e-19, (30.55% identity in 301 aa overlap); BAB50179|MLL3242 CYCLASE (ADENYLYL OR GUANYLYL) from Rhizobium loti (356 aa), FASTA scores: opt: 372, E(): 3.4e-15, (28.75% identity in 219 aa overlap); etc. BELONGS TO ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY.	Q7TYK9	No	intermediary metabolism and respiration							IPR001054,IPR003660	Q7TYK9	A0A1R3Y1E6				Rv2435c		Rv2435c			
NC_002945.3	Mycobrowser_v4	CDS	2697278	2698723	.	-	0	Mb2460c	Mb2460c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2460c, -, len: 481 aa. Equivalent to Rv2434c,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 481 aa overlap). Probable conserved transmembrane protein, with some similarity to BAB48444|MLR0973 PROBABLE INTEGRAL MEMBRANE PROTEIN from Rhizobium loti (410 aa), FASTA scores: opt: 298, E(): 4.1e-11, (27.25% identity in 389 aa overlap); and also similarity with other hypothetical proteins and/or putative integral membrane proteins.	Q7TYL0	No	cell wall and cell processes							IPR000595,IPR006685,IPR010920,IPR014710,IPR016846,IPR018490	Q7TYL0	A0A1R3Y204				Rv2434c		Rv2434c			
NC_002945.3	Mycobrowser_v4	CDS	2702539	2702958	.	+	0	Mb2463	Mb2463		conserved transmembrane protein	Mb2463, -, len: 139 aa. Equivalent to Rv2437, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, with some similarity to CONSERVED HYPOTHETICAL PROTEINS e.g. O06539|RV1139C|MTCI65.06c from Mycobacterium tuberculosis (166 aa); AAK45430|MT1172 from Mycobacterium tuberculosis (124 aa), FASTA scores: opt: 166, E(): 0.00013, (35.7% identity in 112 aa overlap); BAB48937|Mlr1600 from Rhizobium loti (222 aa), FASTA scores: opt: 163 ,E(): 0.00033, (28.1% identity in 121 aa overlap); etc.	Q7TYK7	No	cell wall and cell processes							IPR007318	Q7TYK7	A0A1R3Y167				Rv2437		Rv2437			
NC_002945.3	Mycobrowser_v4	CDS	2704872	2705150	.	+	0	Mb2465	Mb2465		CONSERVED HYPOTHETICAL PROTEIN	Mb2465, -, len: 92 aa. Equivalent to Rv2438A, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Conserved hypothetical protein, showing few similarity with various enzymes e.g. part of O83441|VAA1_TREPA|ATPA1|TP0426 V-TYPE ATP SYNTHASE ALPHA CHAIN 1 (EC 3.6.1.34) from Treponema pallidum (589 aa), FASTA scores: opt: 110, E(): 1.5, (40.3% identity in 72 aa overlap); N-terminus of O95178|NIGM_HUMAN NADH-UBIQUINONE OXIDOREDUCTASE AGGG SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) from Homo sapiens (105 aa), FASTA scores: opt: 109, E(): 1.5, (35.5% identity in 62 aa overlap); N-terminus of Q9HJ76|TA1096 PROBABLE GLYCEROL KINASE from Thermoplasma acidophilum (488 aa); etc.	Q7TYK6	No	conserved hypotheticals								Q7TYK6	A0A1R3Y181				Rv2438A		Rv2438A			
NC_002945.3	Mycobrowser_v4	CDS	2725099	2726355	.	-	0	Mb2483c	Mb2483c		probable conserved integral membrane transport protein	Mb2483c, -, len: 418 aa. Equivalent to Rv2456c,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 418 aa overlap). Probable conserved integral membrane transport protein, involved in a efflux system, weakly similar to many e.g. Q9RUR0|YD22_DEIRA|DR1322 PUTATIVE SUGAR EFFLUX TRANSPORTER from Deinococcus radiodurans (389 aa), FASTA scores: opt: 224, E(): 8.4e-06, (24.45% identity in 409 aa overlap); Q9UYY0|PAB0913 MULTIDRUG RESISTANCE PROTEIN from Pyrococcus abyssi (410 aa), FASTA scores: opt: 210, E(): 5.6e-05, (21.8% identity in 408 aa overlap); etc. Contains PS00216 Sugar transport proteins signature 1.	Q7TYJ4	No	cell wall and cell processes							IPR011701,IPR016196,IPR020846	Q7TYJ4	A0A1R3Y183				Rv2456c		Rv2456c			
NC_002945.3	Mycobrowser_v4	CDS	2744479	2745132	.	-	0	Mb2501c	Mb2501c		CONSERVED HYPOTHETICAL PROTEIN	Mb2501c, -, len: 217 aa. Equivalent to Rv2474c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). Hypothetical protein. Shows weak similarity with Q9L246|SC6D10.18c HYPOTHETICAL 24.9 KDA PROTEIN from Streptomyces coelicolor (238 aa),FASTA scores: opt: 111, E(): 5.6, (30% identity in 233 aa overlap), BLASTP scores: Score= 135, E= 3.5e-07, P= 3.5e-07, Identities= 55/182 (30%).	Q7TYI1	No	conserved hypotheticals							IPR016601	Q7TYI1	A0A1R3Y1P6				Rv2474c		Rv2474c			
NC_002945.3	Mycobrowser_v4	CDS	2713930	2714301	.	-	0	Mb2473c	Mb2473c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2473c, -, len: 123 aa. Equivalent to Rv2446c,len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 123 aa overlap). Probable conserved integral membrane protein, highly similar to Q9CBY9|ML1470 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (123 aa), FASTA scores: opt: 468, E(): 6.7e-23, (66.65% identity in 108 aa overlap). Also similar to Q9L1G5|SCC88.24c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (118 aa), FASTA scores: opt: 130,E(): 0.13, (37.2% identity in 86 aa overlap); and some similarity to O06852|Y13070 hypothetical Streptomyces coelicolor gene also between fpgs and ndk genes (see citation below) (117 aa), FASTA scores: opt: 128, E(): 0.17, (36.0% identity in 86 aa overlap).	Q7TYK2	No	cell wall and cell processes							IPR025327	Q7TYK2	A0A1R3Y174				Rv2446c		Rv2446c			
NC_002945.3	Mycobrowser_v4	CDS	3727662	3728030	.	-	0	Mb3398c	Mb3398c		CONSERVED HYPOTHETICAL PROTEIN	Mb3398c, -, len: 122 aa. Equivalent to Rv3363c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Conserved hypothetical protein, similar to others from Streptomyces coelicolor e.g. O86523|SC1C2.23c (132 aa), FASTA scores: opt: 236, E(): 9e-09, (38.5% identity in 122 aa overlap); O86520|SC1C2.19c (190 aa), FASTA scores: opt: 231, E(): 2.7e-08, (41.0% identity in 122 aa overlap); Q9X834|SC9B1.14c (119 aa), FASTA scores: opt: 188, E(): 1.1e-05, (37.5% identity in 120 aa overlap); Q9ADJ4|SCBAC14E8.05 (113 aa), FASTA scores: opt: 167, E(): 0.00025, (33.05% identity in 109 aa overlap); etc.	Q7TWM5	No	conserved hypotheticals							IPR007995	Q7TWM5	A0A1R3Y400				Rv3363c		Rv3363c			
NC_002945.3	Mycobrowser_v4	CDS	2720425	2720823	.	+	0	Mb2478	Mb2478		HYPOTHETICAL PROLINE AND SERINE RICH PROTEIN	Mb2478, -, len: 132 aa. Equivalent to Rv2451, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 132 aa overlap). Hypothetical unknown pro-, ser-rich protein.	Q7TYJ8	No	conserved hypotheticals								Q7TYJ8	A0A1R3Y170				Rv2451		Rv2451			
NC_002945.3	Mycobrowser_v4	CDS	2721011	2721157	.	-	0	Mb2479c	Mb2479c		HYPOTHETICAL PROTEIN	Mb2479c, -, len: 48 aa. Equivalent to Rv2452c, len: 48 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 48 aa overlap). Hypothetical unknown protein.	Q7TYJ7	No	conserved hypotheticals								Q7TYJ7	A0A1R3Y3E7				Rv2452c		Rv2452c			
NC_002945.3	Mycobrowser_v4	CDS	3728008	3728400	.	-	0	Mb3399c	Mb3399c		conserved protein	Mb3399c, -, len: 130 aa. Equivalent to Rv3364c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Conserved hypothetical protein, highly similar to others from Streptomyces coelicolor e.g. O86524|SC1C2.24c (137 aa),FASTA scores: opt: 466, E(): 1.3e-22, (58.6% identity in 116 aa overlap); O86521|SC1C2.20c (140 aa), FASTA scores: opt: 445, E(): 2.7e-21, (56.9% identity in 116 aa overlap); Q9KZI6|SCG8A.13c (145 aa), FASTA scores: opt: 341, E(): 9.5e-15, (51.3% identity in 113 aa overlap); etc.	Q7TWM4	No	conserved hypotheticals							IPR004942	Q7TWM4	A0A1R3Y461				Rv3364c		Rv3364c			
NC_002945.3	Mycobrowser_v4	CDS	2721788	2722909	.	-	0	Mb2481c	Mb2481c		PROBABLE OXIDOREDUCTASE (BETA SUBUNIT)	Mb2481c, -, len: 373 aa. Equivalent to Rv2454c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Probable oxidoreductase, beta subunit (EC 1.-.-.-), similar to Q9F2W7|SCD20.12c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (352 aa), FASTA scores: opt: 1461, E(): 6.4e-85, (65.3% identity in 343 aa overlap) alias Q9RKS5|STAH10.34c PUTATIVE OXIDOREDUCTASE BETA-SUBUNIT from Streptomyces coelicolor (350 aa), FASTA scores: opt: 1429, E(): 6.7e-83, (64.0% identity in 342 aa overlap); and similar in part to others e.g. Q9Z5X3 FERREDOXIN OXIDOREDUCTASE B-SUBUNIT from Frankia sp. (346 aa), FASTA scores: opt: 1143, E(): 7.5e-65, (51.2% identity in 336 aa overlap); BAB21495|KORB FERREDOXIN OXIDOREDUCTASE BETA SUBUNIT from Hydrogenobacter thermophilus TK-6 (295 aa),FASTA scores: opt: 682, E(): 8.3e-36, (48.25% identity in 201 aa overlap); etc. Note that the upstream ORF (MTV008.11c|Rv2455c) is possibly an oxidoreductase alpha subunit.	Q7TYJ6	No	intermediary metabolism and respiration							IPR011766	Q7TYJ6	A0A1R3Y1H5				Rv2454c		Rv2454c			
NC_002945.3	Mycobrowser_v4	CDS	2722906	2724867	.	-	0	Mb2482c	Mb2482c		PROBABLE OXIDOREDUCTASE (ALPHA SUBUNIT)	Mb2482c, -, len: 653 aa. Equivalent to Rv2455c,len: 653 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 653 aa overlap). Probable oxidoreductase, alpha subunit (EC 1.-.-.-), similar to others e.g. Q9F2W6|SCD20.13c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (645 aa), FASTA scores: opt: 2017,E(): 1e-111, (66.45% identity in 617 aa overlap) alias Q9RKS4|STAH10.35c PUTATIVE OXIDOREDUCTASE ALPHA-SUBUNIT from Streptomyces coelicolor (630 aa), FASTA scores: opt: 2008, E(): 3.4e-111, (66.45% identity in 614 aa overlap); Q9YA13|APE2126 LONG HYPOTHETICAL 2-OXOACID--FERREDOXIN OXIDOREDUCTASE ALPHA CHAIN from Aeropyrum pernix (644 aa) FASTA scores: opt: 687, E(): 4.6e-33, (33.35% identity in 441 aa overlap); etc. Note that the downstream ORF (MTV008.10c|Rv2454c) is possibly an oxidoreductase beta subunit.	Q7TYJ5	No	intermediary metabolism and respiration							IPR002869,IPR002880,IPR009014,IPR019752,IPR022367	Q7TYJ5	A0A1R3Y1M4				Rv2455c		Rv2455c			
NC_002945.3	Mycobrowser_v4	CDS	2729017	2730543	.	+	0	Mb2486	Mb2486		PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN	Mb2486, -, len: 508 aa. Equivalent to Rv2459, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 508 aa overlap). Probable conserved integral membrane transport protein, member of major facilitator superfamily (MFS) possibly involved in drug transport, highly similar to many efflux proteins e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 788, E(): 1.3e-38, (34.45% identity in 412 aa overlap); Q9I428|PA1316 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (513 aa), FASTA scores: opt: 782, E(): 3.1e-38,(32.75% identity in 519 aa overlap); P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa), FASTA scores: opt: 752,E(): 1.8e-36, (31.7% identity in 511 aa overlap); etc. Also highly similar to AAK46687|MT2395 DRUG TRANSPORTER from Mycobacterium tuberculosis strain CDC1551 (537 aa),FASTA scores: opt: 1396, E(): 5.6e-74, (44.45% identity in 504 aa overlap); and P71879|Rv2333c|MTCY3G12.01 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (537 aa), FASTA scores: opt: 1385, E(): 2.5e-73, (44.25% identity in 504 aa overlap).	Q7TYJ2	No	cell wall and cell processes							IPR011701,IPR016196,IPR020846	Q7TYJ2	A0A1R3Y1A4				Rv2459		Rv2459			
NC_002945.3	Mycobrowser_v4	CDS	2735022	2735828	.	-	0	Mb2491c	Mb2491c		POSSIBLE DNA GLYCOSYLASE	Mb2491c, -, len: 268 aa. Equivalent to Rv2464c,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Possible DNA glycosylase (EC 3.2.2.-), showing some similarity to several other DNA glycosylases e.g. Q9F308|SCC80.11c PUTATIVE DNA REPAIR HYDROLASE (FRAGMENT) from Streptomyces coelicolor (306 aa), FASTA scores: opt: 894, E(): 6.1e-51,(51.05% identity in 282 aa overlap); O50606|MUTM|FPG_THETH FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (EC 3.2.2.23) from Thermus aquaticus (267 aa), FASTA scores: opt: 342, E(): 4.6e-15, (32.4% identity in 250 aa overlap); Q9RCW5|SCM10.34c PUTATIVE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Streptomyces coelicolor (287 aa), FASTA scores: opt: 321, E(): 1.1e-13, (29.35% identity in 259 aa overlap); etc. Identical to AAK46839|MT2539 FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium tuberculosis strain CDC1551. Also similar to other M. tuberculosis DNA glycosylases e.g. MTCY71.37 (32.9% identity in 277 aa overlap). BELONGS TO THE FPG FAMILY.	X2BKL9,P64159	No	information pathways								X2BKL9,P64159	P64159				Rv2464c		Rv2464c			
NC_002945.3	Mycobrowser_v4	CDS	2736424	2737047	.	-	0	Mb2493c	Mb2493c		conserved protein	Mb2493c, -, len: 207 aa. Equivalent to Rv2466c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, equivalent to Q9CBY0|ML1485 HYPOTHETICAL PROTEIN from Mycobacterium leprae (207 aa),FASTA scores: opt: 1154, E(): 1.1e-67, (80.6% identity in 206 aa overlap). Also highly similar to Q9L201|SC8E4A.04c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (216 aa), FASTA scores: opt: 789, E(): 4.6e-44, (57.9% identity in 213 aa overlap). Also similar to AAK46628|MT2344 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (230 aa), FASTA scores: opt: 324, E(): 6.1e-14, (30.4% identity in 194 aa overlap). Contains PS00195 Glutaredoxin active site.	Q7TYI8	No	conserved hypotheticals							IPR001853,IPR012336	Q7TYI8	A0A1R3Y191				Rv2466c		Rv2466c			
NC_002945.3	Mycobrowser_v4	CDS	2796600	2796737	.	+	0	Mb2541	Mb2541		CONSERVED HYPOTHETICAL PROTEIN	Mb2541, -, len: 45 aa. Equivalent to Rv2512A, len: 45 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 45 aa overlap). Conserved hypothetical protein, equivalent to N-terminus of Rv1046c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 293, E(): 2.1e-18, (100.0% identity in 42 aa overlap).	Q7TYE9	No									Q7TYE9	A0A1R3Y1N6				Rv2512A		Rv2512A			
NC_002945.3	Mycobrowser_v4	CDS	2740530	2741198	.	-	0	Mb2496c	Mb2496c		CONSERVED HYPOTHETICAL PROTEIN	Mb2496c, -, len: 222 aa. Equivalent to Rv2469c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 222 aa overlap). Conserved hypothetical protein, highly similar to other HYPOTHETICAL PROTEINS e.g. Q9X7B4|MLCB1610.15|ML1254 from Mycobacterium leprae (215 aa), FASTA scores: opt: 1183, E(): 3.3e-70, (77.9% identity in 222 aa overlap); Q9L1Y0|SC8E4A.25c from Streptomyces coelicolor (178 aa), FASTA scores: opt: 589,E(): 1.7e-31, (53.4% identity in 161 aa overlap) (N-terminal region is shorter 50 aa approximatively); Q9RRS6|DR2409 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (186 aa), FASTA scores: opt: 440,E(): 9.6e-22, (42.25% identity in 168 aa overlap) (N-terminal region is shorter 30 aa approximatively); etc.	Q7TYI5	No	conserved hypotheticals							IPR002711,IPR003615	Q7TYI5	A0A1R3Y1B7				Rv2469c		Rv2469c			
NC_002945.3	Mycobrowser_v4	CDS	2804185	2804412	.	-	0	Mb2549c	Mb2549c		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb2549c, -, len: 75 aa. Equivalent to Rv2520c, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 75 aa overlap). Possible conserved membrane protein, equivalent to O07706|MLCL383.32 HYPOTHETICAL 10.0 KDA PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 290, E(): 4.1e-14, (58.65% identity in 75 aa overlap); and Q9CCU6|ML0425 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (75 aa), FASTA scores: opt: 286, E(): 6.6e-14, (57.35% identity in 75 aa overlap).	Q7TYE1	No	cell wall and cell processes							IPR022062	Q7TYE1	A0A1R3Y3J5				Rv2520c		Rv2520c			
NC_002945.3	Mycobrowser_v4	CDS	2743435	2743728	.	+	0	Mb2499	Mb2499		CONSERVED HYPOTHETICAL PROTEIN	Mb2499, -, len: 97 aa. Equivalent to Rv2472, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, showing some similarity to O53451|Rv1103c|MTV017.56c from Mycobacterium tuberculosis strain H37Rv (106 aa), FASTA scores: opt: 135, E(): 0.026,(45.85% identity in 72 aa overlap); and AAK45393|MT1135 HYPOTHETICAL 11.4 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (78 aa) FASTA scores: opt: 139, E(): 0.011, (45.35% identity in 75 aa overlap).	Q7TYI3	No	conserved hypotheticals								Q7TYI3	A0A1R3Y242				Rv2472		Rv2472			
NC_002945.3	Mycobrowser_v4	CDS	2743731	2744447	.	+	0	Mb2500	Mb2500		POSSIBLE ALANINE AND PROLINE RICH MEMBRANE PROTEIN	Mb2500, -, len: 238 aa. Equivalent to Rv2473, len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Possible pro-,ala-rich membrane protein, with possible transmembrane domain around aa 81-104.	Q7TYI2	No	cell wall and cell processes								Q7TYI2	A0A1R3Y1J5				Rv2473		Rv2473			
NC_002945.3	Mycobrowser_v4	CDS	2745138	2745554	.	-	0	Mb2502c	Mb2502c		conserved protein	Mb2502c, -, len: 138 aa. Equivalent to Rv2475c,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Conserved hypothetical protein, showing similarity with Q9L245|SC6D10.19c HYPOTHETICAL 16.2 KDA PROTEIN from Streptomyces coelicolor (136 aa), FASTA scores: opt: 236,E(): 1.9e-09, (34.1% identity in 126 aa overlap). Also some similarity with AAK44393|Z97050|MTCI28_3 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis cosmid I (151 aa), FASTA scores: opt: 147, E(): 0.00025,(29.2% identity in 120 aa overlap).	Q7TYI0	No	conserved hypotheticals								Q7TYI0	A0A1R3Y1A2				Rv2475c		Rv2475c			
NC_002945.3	Mycobrowser_v4	CDS	2937449	2937670	.	-	0	Mb2678c	Mb2678c		HYPOTHETICAL PROTEIN	Mb2678c, -, len: 73 aa. Equivalent to Rv2660c, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). (questionable orf). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 10982 bp deletion leads to deletion of genes between Mb2677c and Mb2678c compared to Mycobacterium tuberculosis strain H37Rv.	Q7TY63	No	conserved hypotheticals								Q7TY63	A0A1R3Y2M8				Rv2660c		Rv2660c			
NC_002945.3	Mycobrowser_v4	CDS	2750526	2752202	.	-	0	Mb2504c	Mb2504c		PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER	Mb2504c, -, len: 558 aa. Equivalent to Rv2477c,len: 558 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 558 aa overlap). Probable ATP binding protein ABC-transporter (see citation below), probably involved in macrolide transport, equivalent to Q9X7B1|MLCB1610.09|ML1248 PUTATIVE ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium leprae (556 aa) FASTA scores: opt: 3448, E(): 3.8e-176, (92.3% identity in 557 aa overlap). Also highly similar to many ATP binding proteins e.g. Q9L244|SC6D10.20c PUTATIVE ABC TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (547 aa),FASTA scores: opt: 2937, E(): 5.6e-149, (79.5% identity in 551 aa overlap); AAK24119|CC2148 ABC transporter ATP-binding protein from Caulobacter crescentus (555 aa),FASTA scores: opt: 2175, E(): 1.9e-108, (59.4% identity in 557 aa overlap); Q9HVJ1 PROBABLE ATP-BINDING COMPONENT OF ABC TRANSPORTER from Pseudomonas aeruginosa (554 aa),FASTA scores: opt: 2054, E(): 5.1e-102, (56.9% identity in 559 aa overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop), 2 x PS00211 ABC transporters family signature, and probable coiled-coil from aa 273 to 311. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TYH8	No	cell wall and cell processes							IPR003439,IPR003593,IPR017871,IPR022374,IPR027417	Q7TYH8	A0A1R3Y1B9				Rv2477c		Rv2477c			
NC_002945.3	Mycobrowser_v4	CDS	2752283	2752768	.	-	0	Mb2505c	Mb2505c		CONSERVED HYPOTHETICAL PROTEIN	Mb2505c, -, len: 161 aa. Equivalent to Rv2478c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Conserved hypothetical protein, with weak similarity with many single-strand binding proteins e.g. Q9X8U3|SCH24.29 PUTATIVE SINGLE-STRAND BINDING PROTEIN from Streptomyces coelicolor (199 aa), FASTA scores: opt: 246, E(): 4.5e-08,(31.5% identity in 162 aa overlap); P46390|SSB_MYCLE|ML2684|MLCB1913.20c SINGLE-STRAND BINDING PROTEIN (SSB) (HELIX-DESTABILIZING PROTEIN) from Mycobacterium leprae (168 aa), FASTA scores: opt: 239,E(): 1e-07, (30.8% identity in 146 aa overlap); P18310|SSBF_ECOLI SINGLE-STRAND BINDING PROTEIN from Escherichia coli (178 aa), FASTA scores: opt: 116, E(): 2.9, (25.7% identity in 140 aa overlap); etc. Also similarity with Rv0054|P71711|MTCY21D4.17|SSB_MYCTU PROBABLE SINGLE-STRAND BINDING PROTEIN from M. tuberculosis (164 aa), FASTA scores: opt: 234, E(): 2e-07,(31.75% identity in 148 aa overlap). N-terminus shorter 8 aa from AAK46855|MT2553 SINGLE-STRAND DNA BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551.	Q7TYH7	No	conserved hypotheticals							IPR000424,IPR011344,IPR012340	Q7TYH7	A0A1R3Y1C2				Rv2478c		Rv2478c			
NC_002945.3	Mycobrowser_v4	CDS	2757821	2759296	.	-	0	Mb2509c	Mb2509c		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb2509c, -, len: 491 aa. Equivalent to Rv2484c,len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 491 aa overlap). Conserved hypothetical protein, highly similar or similar to many Mycobacterial hypothetical proteins e.g. Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 2459, E(): 3e-138, (75.15% identity in 483 aa overlap); O53304|YU87_MYCTU|Rv3087|MTV013.08 from Mycobacterium tuberculosis (472 aa), FASTA scores: opt: 527, E(): 8.1e-24, (29.1% identity in 485 aa overlap); O53305|YU88_MYCTU|Rv3088|MT3173|MTV013.09 from Mycobacterium tuberculosis (474 aa), FASTA scores: opt: 370, E(): 1.6e-14, (26.05% identity in 422 aa overlap); etc.	Q7TYH3	No	lipid metabolism							IPR004255,IPR014292	Q7TYH3	A0A1R3Y252				Rv2484c		Rv2484c			
NC_002945.3	Mycobrowser_v4	CDS	2764268	2767681	.	-	0	Mb2515c	Mb2515c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (LUXR-FAMILY)	Mb2515c, -, len: 1137 aa. Equivalent to Rv2488c,len: 1137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1137 aa overlap). Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190,(52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory proteins luxR-family from other organisms e.g. Q9CBP3|ML1753 from Mycobacterium leprae (1106 aa), FASTA scores: opt: 2823, E(): 1.5e-156, (50.35% identity in 1116 aa overlap); Q9KYF4|SCD72A.02 from Streptomyces coelicolor (1114 aa), FASTA scores: opt: 915,E(): 1.7e-45, (30.7% identity in 1143 aa overlap); etc. Some similarity with Q9KXP6|SC9C5.28 HYPOTHETICAL 81.8 KDA PROTEIN from Streptomyces coelicolor (750 aa), FASTA scores: opt: 1085, E(): 1.6e-55, (35.45% identity in 722 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, probable coiled-coil from aa 585 to 616 and probable helix-turn-helix motif at aa 1086 to 1107 (score 1206, +3.29 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TYH0	No	regulatory proteins							IPR000767,IPR000792,IPR001054,IPR002182,IPR011990,IPR011991,IPR016032,IPR027417	Q7TYH0	A0A1R3Y1C9				Rv2488c		Rv2488c			
NC_002945.3	Mycobrowser_v4	CDS	2773462	2774085	.	+	0	Mb2519	Mb2519		CONSERVED HYPOTHETICAL PROTEIN	Mb2519, -, len: 207 aa. Equivalent to Rv2491, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 293,E(): 2.8e-11, (42.85% identity in 126 aa overlap); O66531|AQ_134 from Aquifex aeolicus (151 aa), FASTA scores: opt: 261, E(): 2.6e-09, (37.75% identity in 106 aa overlap); Q9HKU3|TA0501 from Thermoplasma acidophilum (161 aa), FASTA scores: opt: 260, E(): 3.2e-09, (35.9% identity in 117 aa overlap); etc.	Q7TYG6	No	conserved hypotheticals							IPR005268	Q7TYG6	A0A1R3Y3G8				Rv2491		Rv2491			
NC_002945.3	Mycobrowser_v4	CDS	2774075	2774827	.	+	0	Mb2520	Mb2520		HYPOTHETICAL PROTEIN	Mb2520, -, len: 250 aa. Equivalent to Rv2492, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 250 aa overlap). Hypothetical unknown protein.	Q7TYG5	No	conserved hypotheticals							IPR000398,IPR023451	Q7TYG5	A0A1R3Y264				Rv2492		Rv2492			
NC_002945.3	Mycobrowser_v4	CDS	2779970	2780527	.	-	0	Mb2527c	Mb2527c		POSSIBLE OXIDASE REGULATORY-RELATED PROTEIN	Mb2527c, -, len: 185 aa. Equivalent to Rv2499c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Possible oxidase regulatory-related protein, similar to many maoC MONOAMINE OXIDASE REGULATORY PROTEIN e.g. Q9RUZ1|DR1239 MAOC-RELATED PROTEIN from Deinococcus radiodurans (160 aa), FASTA scores: opt: 519, E(): 7.6e-28, (58.1% identity in 148 aa overlap); BAB48392|MLR0905 Probable monoamine oxidase regulatory protein from Rhizobium loti (Mesorhizobium loti) (150 aa), FASTA scores: opt: 480, E(): 2.9e-25,(49.0% identity in 149 aa overlap); Q9HN18|MAOC1|VNG2290G MONOAMINE OXIDASE REGULATORY-LIKE from Halobacterium sp. strain NRC-1 (208 aa), FASTA scores: opt: 419, E(): 4.6e-21, (45.6% identity in 158 aa overlap); P77455|MAOC_ECOLI|PAAZ|B1387 MaoC protein (Phenylacetic acid degradation protein paaZ) from Escherichia coli strain K12 (681 aa), FASTA scores: opt: 252, E(): 1.9e-09,(36.0% identity in 172 aa overlap); etc. But also similar to other proteins with different putative functions e.g. Q9HRM9|MAOC2|VNG0626G MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Halobacterium sp strain NRC-1 (157 aa), FASTA scores: opt: 380, E(): 1.5e-18, (45.75% identity in 153 aa overlap); Q9KIF1 FKBR2 from Streptomyces hygroscopicus var. ascomyceticus (175 aa), FASTA scores: opt: 355, E(): 7.6e-17, (42.0% identity in 150 aa overlap); CAC36828|Q99Q03|SAPE Spore associated protein from Streptomyces coelicolor (174 aa), FASTA scores: opt: 318,E(): 2.2e-14, (41.45% identity in 152 aa overlap); etc.	Q7TYF8	No	intermediary metabolism and respiration							IPR002539	Q7TYF8	A0A1R3Y1E5				Rv2499c		Rv2499c			
NC_002945.3	Mycobrowser_v4	CDS	2790053	2791390	.	-	0	Mb2536c	Mb2536c		PROBABLE CONSERVED INTEGRAL MEMBRANE LEUCINE AND ALANINE RICH PROTEIN	Mb2536c, -, len: 445 aa. Equivalent to Rv2508c,len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Probable conserved integral membrane leu-, ala-rich protein, equivalent to Q9CCU4|ML0430 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (454 aa) (alias O07710|MLCL383.37 longer 10 aa),FASTA scores: opt: 2205, E(): 2.5e-124, (75.75% identity in 441 aa overlap). Also similar to hypothetical or membrane proteins e.g. BAB50841|MLL4103 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (458 aa),FASTA scores: opt: 396, E(): 2.4e-16, (27.75% identity in 447 aa overlap); Q9RKX9|SC6D7.19c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (486 aa),FASTA scores: opt: 323, E(): 5.7e-12, (28.95% identity in 428 aa overlap); P42306|YXIO_BACSU PROBABLE INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (428 aa), FASTA scores: opt: 220, E(): 7.2e-06, (20.35% identity in 413 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31.04c (548 aa),FASTA scores: opt: 184, E(): 0.0012, (24.7% identity in 466 aa overlap).	Q7TYF2	No	cell wall and cell processes							IPR016196,IPR024671	Q7TYF2	A0A1R3Y1F8				Rv2508c		Rv2508c			
NC_002945.3	Mycobrowser_v4	CDS	2797674	2798135	.	-	0	Mb2543c	Mb2543c		CONSERVED HYPOTHETICAL PROTEIN	Mb2543c, -, len: 153 aa. Equivalent to Rv2514c,len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Conserved hypothetical protein, showing some similarity to Q9PG05|XF0497 HYPOTHETICAL PROTEIN from Xylella fastidiosa (155 aa), FASTA scores: opt: 215, E(): 1.4e-07, (30.6% identity in 160 aa overlap).	Q7TYE7	No	conserved hypotheticals							IPR016541	Q7TYE7	A0A1R3Y1D7				Rv2514c		Rv2514c			
NC_002945.3	Mycobrowser_v4	CDS	2791475	2792281	.	+	0	Mb2537	Mb2537		probable short-chain type dehydrogenase/reductase	Mb2537, -, len: 268 aa. Equivalent to Rv2509, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Probable ala-rich oxidoreductase, short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to O07709|MLCL383.36c|ML0429 DEHYDROGENASE (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (268 aa), FASTA scores: opt: 1509, E(): 2.6e-84,(88.75% identity in 267 aa overlap). Also highly similar to others e.g. O86553|SC1F2.16c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 492, E(): 9.5e-23, (38.15% identity in 262 aa overlap); Q9I5R3|PA0658 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (266 aa), FASTA scores: opt: 472,E(): 1.5e-21, (37.8% identity in 246 aa overlap); AAK22120|CC0133 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus (266 aa), FASTA scores: opt: 428, E(): 6.9e-19,(35.8% identity in 243 aa overlap); etc. Also highly similar or similar to oxidoreductases from Mycobacterium tuberculosis e.g. Q10782|Rv1544|MTCY48.21 PUTATIVE KETOACYL REDUCTASE (EC 1.3.1.-) (267 aa), FASTA scores: opt: 656, E(): 1.1e-32, (43.05% identity in 267 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TYF1	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904	Q7TYF1	A0A1R3Y1F1				Rv2509		Rv2509			
NC_002945.3	Mycobrowser_v4	CDS	2788509	2789156	.	+	0	Mb2534	Mb2534		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb2534, -, len: 215 aa. Equivalent to Rv2506, len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Probable transcriptional regulator, tetR family, similar to many others e.g. Q9L078|SCC105.06c PUTATIVE TETR-FAMILY REGULATORY PROTEIN from Streptomyces coelicolor (208 aa),FASTA scores: opt: 333, E(): 1.5e-14, (48.75% identity in 197 aa overlap); Q9X7X6|SC6A5.30c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (404 aa), FASTA scores: opt: 267, E(): 4.8e-10, (30.45% identity in 207 aa overlap) (similarity only with C-terminus for this one); Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa), FASTA scores: opt: 239, E(): 1.8e-08, (29.9% identity in 184 aa overlap); etc. Also similar to transcriptional regulatory proteins from Mycobacterium tuberculosis e.g. O05858|Rv3208|MTCY07D11.18c (228 aa), FASTA scores: opt: 218, E(): 4.4e-07, (30.35% identity in 191 aa overlap); C-terminus of P95251|Rv1963c|MTV051.01c|MTCY09F9.01 (406 aa), FASTA scores: opt: 238, E(): 3.6e-08, (28.25% identity in 177 aa overlap); P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: 215, E(): 6.2e-07, (38.25% identity in 148 aa overlap); etc. Equivalent to AAK46885 from Mycobacterium tuberculosis strain CDC1551 (231 aa) but shorter 16 aa. Contains probable helix-turn-helix motif at aa 46-67, (Score 1660, +4.84 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TYF4	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TYF4	A0A1R3Y1E9				Rv2506		Rv2506			
NC_002945.3	Mycobrowser_v4	CDS	2789235	2790056	.	+	0	Mb2535	Mb2535		POSSIBLE CONSERVED PROLINE RICH MEMBRANE PROTEIN	Mb2535, -, len: 273 aa. Equivalent to Rv2507, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Possible conserved pro-rich membrane protein (N-terminal half is Proline-rich), highly similar to Q9CCU3|ML0431 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (259 aa) (alias O07711|MLCL383.38c but longer 2 aa), FASTA scores: opt: 968, E(): 1.4e-31, (60.35% identity in 275 aa overlap). Contains potential membrane spanning region.	Q7TYF3	No	cell wall and cell processes							IPR008693	Q7TYF3	A0A1R3Y1E8				Rv2507		Rv2507			
NC_002945.3	Mycobrowser_v4	CDS	2894443	2894937	.	+	0	Mb2629	Mb2629		CONSERVED HYPOTHETICAL PROTEIN	Mb2629, -, len: 164 aa. Equivalent to Rv2598, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins from Streptomyces coelicolor e.g. Q9X8S3|SCH10.34c (185 aa), FASTA scores: opt: 197, E(): 3.5e-06, (34.75% identity in 167 aa overlap); and Q9L088|SCC24.29c (172 aa), FASTA scores: opt: 149, E(): 0.0053, (37.65% identity in 146 aa overlap). Equivalent to AAK46988 from Mycobacterium tuberculosis strain CDC1551 (154 aa) but longer 10 aa.	X2BLD8	No	conserved hypotheticals								X2BLD8	P65032				Rv2598		Rv2598			
NC_002945.3	Mycobrowser_v4	CDS	2792285	2793886	.	-	0	Mb2538c	Mb2538c		conserved protein	Mb2538c, -, len: 533 aa. Equivalent to Rv2510c,len: 533 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 533 aa overlap). Hypothetical unknown protein, highly similar, but longer approximatively 20 aa,to others e.g. Q9ABY0|CC0090 HYPOTHETICAL PROTEIN from Caulobacter crescentus (516 aa), FASTA scores: opt: 1282,E(): 8.4e-63, (45.1% identity in 490 aa overlap); Q9A130|SPY0500 HYPOTHETICAL PROTEIN from Streptococcus pyogenes (500 aa), FASTA scores: opt: 1281, E(): 9.3e-63,(43.8% identity in 491 aa overlap); Q985L5|MLR7622 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (515 aa), FASTA scores: opt: 1259, E(): 1.5e-61,(44.1% identity in 510 aa overlap); P39342|YJGR_ECOLI|B4263 HYPOTHETICAL 54.3 KDA PROTEIN from Escherichia coli strain K12 (500 aa), FASTA scores: opt: 1257, E(): 1.9e-61, (42.7% identity in 501 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TYF0	No	conserved hypotheticals							IPR008571,IPR027417	Q7TYF0	A0A1R3Y1D2				Rv2510c		Rv2510c			
NC_002945.3	Mycobrowser_v4	CDS	2795353	2796600	.	-	0	Mb2540c	Mb2540c		TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081	Mb2540c, -, len: 415 aa. Equivalent to Rv2512c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Transposase for IS1081, identical to P35882|TRA1_MYCBO transposase for insertion sequence element IS1081 from Mycobacterium bovis (415 aa), FASTA scores: opt: 2680, E(): 1.9e-162, (100.0% identity in 415 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV01 2.38c (415 aa), FASTA scores: opt: 2675, E(): 3.9e-162,(99.75% identity in 415 aa overlap). Contains PS00435 Peroxidases proximal heme-ligand signature, PS01007 Transposases, Mutator family, signature. BELONGS TO THE MUTATOR FAMILY OF TRANSPOSASE.	X2BGW7,P60231	No	insertion seqs and phages								X2BGW7,P60231	P60231				Rv2512c		Rv2512c			
NC_002945.3	Mycobrowser_v4	CDS	2798141	2799388	.	-	0	Mb2544c	Mb2544c		CONSERVED HYPOTHETICAL PROTEIN	Mb2544c, -, len: 415 aa. Equivalent to Rv2515c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Conserved hypothetical protein, showing some similarity to Q9PG06|XF0496 HYPOTHETICAL PROTEIN from Xylella fastidiosa (391 aa), FASTA scores: opt: 388, E(): 4.4e-18, (27.8% identity in 399 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.	Q7TYE6	No	conserved hypotheticals							IPR001387,IPR010359,IPR010982	Q7TYE6	A0A1R3Y1F6				Rv2515c		Rv2515c			
NC_002945.3	Mycobrowser_v4	CDS	2799507	2800310	.	-	0	Mb2545c	Mb2545c		HYPOTHETICAL PROTEIN	Mb2545c, -, len: 267 aa. Equivalent to Rv2516c,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(99.625% identity in 267 aa overlap). Hypothetical unknown protein. Contains probable helix-turn-helix motif at aa 98 to 119 (Score 1743, +5.12 SD). C-terminus extended since first submission (+ 18 aa).	Q7TYE5	No	conserved hypotheticals								Q7TYE5	A0A1R3Y1F5				Rv2516c		Rv2516c			
NC_002945.3	Mycobrowser_v4	CDS	2804926	2806338	.	-	0	Mb2551c	Mb2551c		CONSERVED HYPOTHETICAL PROTEIN	Mb2551c, -, len: 470 aa. Equivalent to Rv2522c,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 470 aa overlap). Conserved hypothetical protein, equivalent, but longer 20 aa, to Q9X7E4|ML1193|MLCB458.08 from HYPOTHETICAL 46.6 KDA PROTEIN Mycobacterium leprae (442 aa), FASTA scores: opt: 2521, E(): 4.1e-142, (86.35% identity in 440 aa overlap). Also similar to various proteins e.g. Q9K425|SCG22.20 PUTATIVE PEPTIDASE from Streptomyces coelicolor (451 aa),FASTA scores: opt: 1097, E(): 1.1e-57, (42.5% identity in 451 aa overlap); Q9FCK3|2SC3B6.09 PUTATIVE PEPTIDASE from Streptomyces coelicolor (470 aa), FASTA scores: opt: 669,E(): 2.8e-32, (34.2% identity in 462 aa overlap); Q98AF9|MLL6018 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (486 aa), FASTA scores: opt: 622,E(): 1.7e-29, (33.95% identity in 442 aa overlap); Q9RSU7|DR2025 ARGE/DAPE/ACY1 FAMILY PROTEIN from Deinococcus radiodurans (459 aa), FASTA scores: opt: 616,E(): 3.7e-29, (34.15% identity in 442 aa overlap); etc (include some similarity to hypothetical proteins from C. elegans and yeast). Alternative start possible at 6687 but then no RBS obvious.	Q7TYD9	No	conserved hypotheticals							IPR002933,IPR011650	Q7TYD9	A0A1R3Y1P4				Rv2522c		Rv2522c			
NC_002945.3	Mycobrowser_v4	CDS	2816649	2817371	.	-	0	Mb2554c	Mb2554c		conserved hypothetical protein. secreted; predicted to be a substrate of the twin arginine translocation (tat) export system.	Mb2554c, -, len: 240 aa. Equivalent to Rv2525c,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Conserved hypothetical protein, equivalent to Q9X7E1|ML1190|MLCB458.05 HYPOTHETICAL 25.3 KDA PROTEIN from Mycobacterium leprae (239 aa), FASTA scores: opt: 1358, E(): 1e-75, (82.15% identity in 241 aa overlap).	Q7TYD7	No	conserved hypotheticals							IPR006311,IPR013781,IPR015020,IPR017853,IPR019546	Q7TYD7	A0A1R3Y1G1				Rv2525c		Rv2525c			
NC_002945.3	Mycobrowser_v4	CDS	2819672	2821063	.	+	0	Mb2558	Mb2558		HYPOTHETICAL PROTEIN	Mb2558, -, len: 463 aa. Equivalent to Rv2529, len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 463 aa overlap). Hypothetical unknown protein. Note that C-terminal part is similar to short region of Q53609|MTS1_STRAL|SALIM MODIFICATION METHYLASE SALI from Streptomyces albus G (587 aa), FASTA scores: opt: 170, E(): 0.016, (59.45% identity in 37 aa overlap).	Q7TYD3	No	conserved hypotheticals							IPR006166,IPR011335,IPR020819,IPR024412	Q7TYD3	A0A1R3Y1F9				Rv2529		Rv2529			
NC_002945.3	Mycobrowser_v4	CDS	2836706	2837080	.	-	0	Mb2578A	Mb2578A		Conserved protein	Mb2578A, len: 124 aa. Equivalent to Rv2548A len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Transferred manually from H37Rv. Conserved protein.	X2BKT1	No	conserved hypotheticals								X2BKT1	A0A1R3Y2C5				Rv2548A		Rv2548A			
NC_002945.3	Mycobrowser_v4	CDS	2867674	2868138	.	-	0	Mb2606c	Mb2606c		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb2606c, -, len: 154 aa. Equivalent to Rv2576c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Possible conserved membrane protein, showing similarity with Q9ZFC2 HYPOTHETICAL 15.7 KDA PROTEIN from Mycobacterium sp. FM10 (146 aa), FASTA scores: opt: 235, E(): 4.1e-08, (31.35% identity in 150 aa overlap).	X2BL90,P65022	No	cell wall and cell processes								X2BL90,P65022	P65022				Rv2576c		Rv2576c			
NC_002945.3	Mycobrowser_v4	CDS	2821735	2824578	.	-	0	Mb2560c	Mb2560c		PROBABLE AMINO ACID DECARBOXYLASE	Mb2560c, -, len: 947 aa. Equivalent to Rv2531c,len: 947 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 947 aa overlap). Probable amino acid decarboxylase (EC 4.1.1.-), equivalent to Q9CCR8|ADI|ML0524 PUTATIVE AMINO ACID DECARBOXYLASE from Mycobacterium leprae (950 aa), FASTA scores: opt: 5426,E(): 0, (86.45% identity in 951 aa overlap). Also similar to other amino acid decarboxylases (but longer in N-terminus) e.g. Q9I2S7|PA1818 PROBABLE ORN/ARG/LYS AMINO ACID DECARBOXYLASE from Pseudomonas aeruginosa (751 aa),FASTA scores: opt: 434, E(): 2.5e-19, (29.15% identity in 738 aa overlap); Q9CML3|SPEF|PM0806 ORNITHINE DECARBOXYLASE from Pasteurella multocida (720 aa), FASTA scores: opt: 402, E(): 2.4e-17, (24.85% identity in 752 aa overlap); P21169|DCOR_ECOLI|SPEC|B2965|BAB37264|ECS3841|AAG58096 ORNITHINE DECARBOXYLASE ISOZYME (CONSTITUTIVE ENZYME) from Escherichia coli strain K12 (711 aa), FASTA scores: opt: 396, E(): 5.6e-17, (28.0% identity in 646 aa overlap); P44317|DCOR_HAEIN|SPEF|HI0591 ORNITHINE DECARBOXYLASE from Haemophilus influenzae (720 aa), FASTA scores: opt: 393,E(): 8.8e-17, (25.05% identity in 743 aa overlap) ; etc. SEEMS TO BELONG TO FAMILY 1 OF ORNITHINE, LYSINE, AND ARGININE DECARBOXYLASES. Note that previously known as adi.	Q7TYD0	No	intermediary metabolism and respiration							IPR000310,IPR008286,IPR015421,IPR015422,IPR015424	Q7TYD0	A0A1R3Y1Q3				Rv2531c		Rv2531c			
NC_002945.3	Mycobrowser_v4	CDS	2937667	2938056	.	-	0	Mb2679c	Mb2679c		HYPOTHETICAL PROTEIN	Mb2679c, -, len: 129 aa. Equivalent to Rv2661c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Hypothetical unknown protein.	Q7TY62	No	conserved hypotheticals								Q7TY62	A0A1R3Y216				Rv2661c		Rv2661c			
NC_002945.3	Mycobrowser_v4	CDS	4133531	4133890	.	+	0	Mb3774	Mb3774		CONSERVED HYPOTHETICAL PROTEIN	Mb3774, -, len: 119 aa. Equivalent to Rv3748, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 119 aa overlap). Hypothetical protein,highly similar to upstream ORF O69714|Rv3747|MTV025.095 CONSERVED HYPOTHETICAL PROTEIN (127 aa), FASTA scores: opt: 496, E(): 2.5e-28, (64.4% identity in 118 aa overlap).	Q7TVS5	No	conserved hypotheticals								Q7TVS5	A0A1R3Y519				Rv3748		Rv3748			
NC_002945.3	Mycobrowser_v4	CDS	2827249	2827941	.	+	0	Mb2565	Mb2565		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2565, -, len: 230 aa. Equivalent to Rv2536, len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CCS2|ML0520 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (202 aa), FASTA scores: opt: 812, E(): 2e-41, (63.2% identity in 201 aa overlap). Also similar in part to Q9HMD5|VNG2594c from Halobacterium sp. strain NRC-1 (117 aa), FASTA scores: opt: 33.6, E(): 1.8, (33.6% identity in 116 aa overlap); and perhaps AAK65752|SMA1996 PUTATIVE ABC TRANSPORTER PERMEASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (323 aa), FASTA scores: opt: 117, E(): 6.1, (30.6% identity in 121 aa overlap).	Q7TYC6	No	cell wall and cell processes							IPR009698	Q7TYC6	A0A1R3Y1I2				Rv2536		Rv2536			
NC_002945.3	Mycobrowser_v4	CDS	2926797	2927282	.	-	0	Mb2666c	Mb2666c		HYPOTHETICAL PROTEIN	Mb2666c, -, len: 161 aa. Equivalent to Rv2633c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Hypothetical unknown protein.	X2BLF5	No	conserved hypotheticals								X2BLF5	P65036				Rv2633c		Rv2633c			
NC_002945.3	Mycobrowser_v4	CDS	2831224	2831631	.	+	0	Mb2570	Mb2570		HYPOTHETICAL ALANINE RICH PROTEIN	Mb2570, -, len: 135 aa. Equivalent to Rv2541, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Hypothetical unknown ala-rich protein, equivalent to AAK46926|MT2615.1 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 but AAK46926|MT2615.1 longer at C-terminus. Questionable ORF. Some similarity with Rv2077A from Mycobacterium tuberculosis (99 aa).	Q7TYC5	No	conserved hypotheticals							IPR022536	Q7TYC5	A0A1R3Y1R3				Rv2541		Rv2541			
NC_002945.3	Mycobrowser_v4	CDS	2831927	2833138	.	+	0	Mb2571	Mb2571		conserved hypothetical protein	Mb2571, -, len: 403 aa. Equivalent to Rv2542, len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 265 aa overlap). Conserved hypothetical protein, highly similar to AAK46927|MT2616 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa), FASTA scores: opt: 1776, E(): 2.3e-94,(99.25% identity in 265 aa overlap). And similar to several hypothetical proteins from Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. P71654|Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: opt: 537, E(): 2.6e-23, (40.75% identity in 292 aa overlap); P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 (266 aa),FASTA scores: opt: 357, E(): 2.6e-13, (34.6% identity in 234 aa overlap); Q10685|YK77_MYCTU|Rv2077c|MT2137|MTCY49.16c (323 aa),FASTA scores: opt: 261, E(): 9.5e-08, (32.7% identity in 211 aa overlap); etc. Also similar to Q9RDQ9|SC4A7.03 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FASTA scores: opt: 247, E(): 7.3e-07, (30.35% identity in 303 aa overlap).	Q7TYC4	No	conserved hypotheticals							IPR010427	Q7TYC4	A0A1R3Y1X4				Rv2542		Rv2542			
NC_002945.3	Mycobrowser_v4	CDS	2937962	2938234	.	+	0	Mb2680	Mb2680		HYPOTHETICAL PROTEIN	Mb2680, -, len: 90 aa. Equivalent to Rv2662, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein.	Q7TY61	No	conserved hypotheticals								Q7TY61	A0A1R3Y279				Rv2662		Rv2662			
NC_002945.3	Mycobrowser_v4	CDS	2839464	2840717	.	-	0	Mb2583c	Mb2583c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb2583c, -, len: 417 aa. Equivalent to Rv2553c,len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 417 aa overlap). Probable conserved membrane protein, equivalent to Q9CCS8|ML0514 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (421 aa), FASTA scores: opt: 1955, E(): 1.1e-111, (72.7% identity in 414 aa overlap). Also similar in part to various proteins e.g. Q9L9G6|NOVB NOVB PROTEIN (aminodesoxychorismate lyase) from Streptomyces sphaeroides (284 aa), FASTA scores: opt: 451, E(): 2.9e-2, (37.95% identity in 203 aa overlap); Q9EWY3|2SCG38.36 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (253 aa), FASTA scores: opt: 419,E(): 2.3e-18, (39.2% identity in 171 aa overlap); Q9CHT3|YGCC HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (550 aa), FASTA scores: opt: 379, E(): 1.2e-15, (23.0% identity in 417 aa overlap); O25309|HP0587 AMINODEOXYCHORISMATE LYASE (PABC) from Helicobacter pylori (Campylobacter pylori) (329 aa),FASTA scores: opt: 290, E(): 2e-10, (31.65% identity in 180 aa overlap); etc.	Q7TYB2	No	cell wall and cell processes							IPR003770	Q7TYB2	A0A1R3Y1I9				Rv2553c		Rv2553c			
NC_002945.3	Mycobrowser_v4	CDS	2840710	2841222	.	-	0	Mb2584c	Mb2584c		conserved protein	Mb2584c, -, len: 170 aa. Equivalent to Rv2554c,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 170 aa overlap). Conserved hypothetical protein, equivalent to Q9CCS9|ML0513 HYPOTHETICAL PROTEIN from Mycobacterium leprae (184 aa),FASTA scores: opt: 701, E(): 2e-34, (72.05% identity in 161 aa overlap). Also highly similar to Q9KXQ0|SC9C5.24c HYPOTHETICAL 17.7 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 461, E(): 2.3e-20, (54.65% identity in 150 aa overlap); and similar to other hypothetical proteins e.g. Q9KDE4 from Bacillus halodurans (140 aa), FASTA scores: opt: 291, E(): 1.9e-10, (38.7% identity in 137 aa overlap); P74662|SLL1547 from Synechocystis sp. strain PCC 6803 (152 aa), FASTA scores: opt: 290, (36.55% identity in 145 aa overlap); Q52673|YQGF_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (159 aa), FASTA scores: opt: 246, E(): 8.4e-08, (34.8% identity in 135 aa overlap); etc.	X2BLB4,P67488	No	conserved hypotheticals								X2BLB4,P67488	P67488				Rv2554c		Rv2554c			
NC_002945.3	Mycobrowser_v4	CDS	2796958	2797380	.	+	0	Mb2542	Mb2542		HYPOTHETICAL PROTEIN	Mb2542, -, len: 140 aa. Equivalent to Rv2513, len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 140 aa overlap). Hypothetical unknown protein.	Q7TYE8	No	conserved hypotheticals								Q7TYE8	A0A1R3Y1T5				Rv2513		Rv2513			
NC_002945.3	Mycobrowser_v4	CDS	2844028	2844417	.	-	0	Mb2586c	Mb2586c		CONSERVED HYPOTHETICAL PROTEIN	Mb2586c, -, len: 129 aa. Equivalent to Rv2556c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, highly similar to others e.g. Q9EWY5|2SCG38.34 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (140 aa), FASTA scores: opt: 488,E(): 8.2e-26, (58.8% identity in 131 aa overlap); Q9L9G4|NOVD NOVD PROTEIN from Streptomyces sphaeroides (143 aa), FASTA scores: opt: 474, E(): 7.2e-25, (60.85% identity in 120 aa overlap); Q9X2I5|TM1872 from Thermotoga maritima (132 aa), FASTA scores: opt: 270, E(): 2.7e-11,(39.55% identity in 129 aa overlap); etc.	X2BL61	No	conserved hypotheticals								X2BL61	P67122				Rv2556c		Rv2556c			
NC_002945.3	Mycobrowser_v4	CDS	2846023	2847381	.	-	0	Mb2589c	Mb2589c		CONSERVED HYPOTHETICAL ALANINE LEUCINE VALINE RICH PROTEIN	Mb2589c, -, len: 452 aa. Equivalent to Rv2559c,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 452 aa overlap). Conserved hypothetical ala-, leu-, val-rich protein, equivalent to Q9CCT1|ML0510 HYPOTHETICAL PROTEIN from Mycobacterium leprae (473 aa),FASTA scores: opt: 2411, E(): 3.9e-121, (83.4% identity in 452 aa overlap); O69490|O69490 HYPOTHETICAL 47.1 KDA PROTEIN from Mycobacterium leprae (447 aa), FASTA scores: opt: 2406, E(): 6.9e-121, (83.95% identity in 448 aa overlap). Also highly similar to Q9KXP4|SC9C5.30c CONSERVED ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (451 aa), FASTA scores: opt: 1742, E(): 1.5e-85, (64.4% identity in 430 aa overlap); Q9RT67|DR1898 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (434 aa), FASTA scores: opt: 1147, E(): 6.6e-54, (46.0% identity in 415 aa overlap); P45262|YCAJ_HAEIN|HI1590 HYPOTHETICAL PROTEIN from Haemophilus influenzae (446 aa), FASTA scores: opt: 1140,E(): 1.6e-53, (42.5% identity in 428 aa overlap); etc. Also similar to Q50629|MTCY227.09|RUVB|Rv2592c|MT2669|MTCY227.09 HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium tuberculosis (344 aa), (30.1% identity in 296 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TYB0	No	conserved hypotheticals							IPR003593,IPR003959,IPR008921,IPR021886,IPR027417	Q7TYB0	A0A1R3Y1T6				Rv2559c		Rv2559c			
NC_002945.3	Mycobrowser_v4	CDS	2847527	2848504	.	+	0	Mb2590	Mb2590		PROBABLE PROLINE AND GLYCINE RICH TRANSMEMBRANE PROTEIN	Mb2590, -, len: 325 aa. Equivalent to Rv2560, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). Probable transmembrane protein, pro-, gly-rich protein.	X2BL32,P59983	No	cell wall and cell processes								X2BL32,P59983	P59983				Rv2560		Rv2560			
NC_002945.3	Mycobrowser_v4	CDS	2848861	2849598	.	+	0	Mb2591	Mb2591		CONSERVED HYPOTHETICAL PROTEIN	Mb2591, -, len: 245 aa. Similar to Rv2561 and Rv2562, len: 97 aa and 129 aa, from Mycobacterium tuberculosis strain H37Rv, (87.3% identity in 79 aa overlap and 99.2% identity in 129 aa overlap). Conserved hypothetical protein, highly similar in part (and longer 33 aa) to upstream ORF AAK46951|RV2562|MT2638|MTCY9C4.06c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (212 aa), FASTA scores: opt: 205, E(): 2e-06,(76.1% identity in 46 aa overlap). Conserved hypothetical protein, highly similar, but shorter 83 aa, to downstream ORF AAK46951|RV2561|MT2638|MTCY9C4.07c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 aa), FASTA scores: opt: 866, E(): 2.2e-54, (100.0% identity in 129 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis, a single base deletion (g-*) results in a single product which is more similar to Rv2561.	Q7TYA9	No								IPR020503	Q7TYA9	A0A1R3Y1J7									
NC_002945.3	Mycobrowser_v4	CDS	2849741	2850790	.	+	0	Mb2592	Mb2592		PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER	Mb2592, -, len: 349 aa. Equivalent to Rv2563, len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 349 aa overlap). Probable glutamine-transport transmembrane protein ABC transporter (see citation below), highly similar to O53617|Rv0072|MTV030.16 PUTATIVE ABC-TRANSPORTER TRANSMEMBRANE SUBUNIT from Mycobacterium tuberculosis (349 aa), FASTA scores: opt: 1772, E(): 1.1e-89, (76.2% identity in 349 aa overlap). Also some similarity with various hypothetical proteins e.g. Q9RYN1|DRA0279 HYPOTHETICAL 37.1 KDA PROTEIN from Deinococcus radiodurans (353 aa), FASTA scores: opt: 347, E(): 6.6e-12, (24.35% identity in 357 aa overlap); BAB58522|SAV2360 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (351 aa), FASTA scores: opt: 262, E(): 2.9e-07, (19.4% identity in 356 aa overlap); Q9AK94|SC10A9.10c PUTATIVE ABC TRANSPORT SYSTEM TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 172, E(): 0.025, (26.85% identity in 387 aa overlap); etc.	X2BLQ1,P65008	No	cell wall and cell processes								X2BLQ1,P65008	P65008				Rv2563		Rv2563			
NC_002945.3	Mycobrowser_v4	CDS	3029499	3029630	.	-	0	Mb2784c	Mb2784c		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb2784c, -, len: 43 aa. Equivalent to 5' end of Rv2762c, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 43 aa overlap). Conserved hypothetical protein, similar to C-terminus of hypothetical proteins: Q9A380|CC3324 from Caulobacter crescentus (409 aa), FASTA scores: opt: 181, E(): 9.8e-05,(43.55% identity in 101 aa overlap); Q98KQ4|MLR1373 from Rhizobium loti (Mesorhizobium loti) (399 aa), FASTA scores: opt: 174, E(): 0.00028, (46.35% identity in 82 aa overlap); and Q9HZZ9|PA2844 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 158, E(): 0.0033, (40.0% identity in 80 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2762c into 2 parts, Mb2783c and Mb2784c.	Q7TXX9	No									Q7TXX9	A0A1R3Y253									
NC_002945.3	Mycobrowser_v4	CDS	2852062	2853813	.	+	0	Mb2594	Mb2594		conserved protein	Mb2594, -, len: 583 aa. Equivalent to Rv2565, len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 583 aa overlap). Conserved hypothetical protein, similar in part to Q9A6C3|CC2171 HYPOTHETICAL PROTEIN from Caulobacter crescentus (610 aa),FASTA scores: opt: 765, E(): 2.8e-37, (32.15% identity in 575 aa overlap). C-terminus also highly similar to various bacterial proteins e.g. O34731|YLBK_BACSU HYPOTHETICAL 28.3 KDA PROTEIN from Bacillus subtilis (260 aa), FASTA scores: opt: 386, E(): 2.2e-15, (33.05% identity in 245 aa overlap); CAC45997|SMC01003 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (321 aa),FASTA scores: opt: 352, E(): 2.5e-13, (29.65% identity in 280 aa overlap); Q9K9Q8|BH2587 HYPOTHETICAL PROTEIN from Bacillus halodurans (275 aa), FASTA scores: opt: 334, E(): 2.5e-12, (33.7% identity in 175 aa overlap); etc. And shows similarity to C-terminal half of some eukaryotic proteins e.g. Q9R114|NTE NEUROPATHY TARGET ESTERASE HOMOLOG from Mus musculus (Mouse) (1327 aa), FASTA scores: opt: 411, E(): 2.7e-16, (24.45% identity in 626 aa overlap); O60859 NEUROPATHY TARGET ESTERASE from Homo sapiens (Human) (1327 aa), FASTA scores: opt: 410, E(): 3.1e-16, (24.1% identity in 627 aa overlap); Q9U969|SWS|CG2212 SWISS CHEESE PROTEIN from Drosophila melanogaster (Fruit fly) (1425 aa), FASTA scores: opt: 401, E(): 1.1e-15, (27.75% identity in 544 aa overlap); etc. Also shows strong similarity to C-terminal half of O05884|Z95121|Rv3239c|MTY20B11.14c HYPOTHETICAL 110.2 KDA PROTEIN from Mycobacterium tuberculosis (1048 aa), FASTA scores: opt: 648, E(): 3e-30, (36.55% identity in 572 aa overlap); and O69695|Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 643, E(): 6e-30, (34.3% identity in 595 aa overlap).	X2BLC0,P0A643	No	conserved hypotheticals								X2BLC0,P0A643	P0A643				Rv2565		Rv2565			
NC_002945.3	Mycobrowser_v4	CDS	2853824	2855425	.	+	0	Mb2595	Mb2595		LONG CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb2595, -, len: 533 aa. Equivalent to 5' end of Rv2566, len: 1140 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 531 aa overlap). Long conserved hypothetical protein, equivalent to O53120|ML2678 OR MLCB1913.12 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1000 aa), FASTA scores: opt: 760,E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and middle part equivalent to Q9ZB40 72.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (644 aa), FASTA scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77,(52.4% identity in 1148 aa overlap); and N-terminus shows similarity with other proteins e.g. Q9HUN8|PA4926 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (311 aa),FASTA scores: opt: 278, E(): 3e-09, (29.95% identity in 284 aa overlap); and upstream ORF Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (314 aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity in 315 aa overlap). Equivalent to AAK46955 from Mycobacterium tuberculosis strain CDC1551 (1156 aa) but shorter 16 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts, Mb2595 and Mb2596.	Q7TYA8	No								IPR002931,IPR013589,IPR018667	Q7TYA8	A0A1R3Y1K4									
NC_002945.3	Mycobrowser_v4	CDS	2862342	2863409	.	-	0	Mb2601c	Mb2601c		PROBABLE TRANSMEMBRANE ALANINE AND VALINE AND LEUCINE RICH PROTEIN	Mb2601c, -, len: 355 aa. Equivalent to Rv2571c,len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 355 aa overlap). Probable transmembrane ala-, val-, leu-rich protein, showing some similarity with other membrane proteins e.g. Q99340|YFDA_CORGL HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (359 aa), FASTA scores: opt: 338, E(): 2.5e-13, (29.4% identity in 255 aa overlap); Q9RD86|SCF43.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 208, E(): 2.1e-05, (26.05% identity in 303 aa overlap); Q9RD81|SCF43.07 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (419 aa), FASTA scores: opt: 205, E(): 3.5e-05, (25.15% identity in 362 aa overlap); etc.	X2BL82,P65016	No	cell wall and cell processes								X2BL82,P65016	P65016				Rv2571c		Rv2571c			
NC_002945.3	Mycobrowser_v4	CDS	2855451	2857244	.	+	0	Mb2596	Mb2596		LONG CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb2596, -, len: 597 aa. Equivalent to 3' end of Rv2566, len: 1140 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 597 aa overlap). Long conserved hypothetical protein, equivalent to O53120|ML2678 OR MLCB1913.12 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1000 aa), FASTA scores: opt: 760,E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and middle part equivalent to Q9ZB40 72.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (644 aa), FASTA scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77,(52.4% identity in 1148 aa overlap); and N-terminus shows similarity with other proteins e.g. Q9HUN8|PA4926 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (311 aa),FASTA scores: opt: 278, E(): 3e-09, (29.95% identity in 284 aa overlap); and upstream ORF Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (314 aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity in 315 aa overlap). Equivalent to AAK46955 from Mycobacterium tuberculosis strain CDC1551 (1156 aa) but shorter 16 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts, Mb2595 and Mb2596.	Q7TYA7	No								IPR018667	Q7TYA7	A0A1R3Y1K2									
NC_002945.3	Mycobrowser_v4	CDS	2866787	2867668	.	+	0	Mb2605	Mb2605		POSSIBLE CONSERVED MEMBRANE GLYCINE RICH PROTEIN	Mb2605, -, len: 293 aa. Equivalent to Rv2575, len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 293 aa overlap). Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (313 aa), FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature.	X2BL41,P65020	No	cell wall and cell processes								X2BL41,P65020	P65020				Rv2575		Rv2575			
NC_002945.3	Mycobrowser_v4	CDS	2857244	2859898	.	+	0	Mb2597	Mb2597		CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH PROTEIN	Mb2597, -, len: 884 aa. Equivalent to Rv2567, len: 884 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 884 aa overlap). Conserved hypothetical ala-, leu-rich protein, equivalent to O53121|ML2679|MLCB1913.13 HYPOTHETICAL PROTEIN from Mycobacterium leprae (893 aa), FASTA scores: opt: 4326,E(): 0, (75.2% identity in 883 aa overlap); and similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 HYPOTHETICAL 61.8 KDA PROTEIN from Mycobacterium leprae (561 aa), FASTA scores: opt: 758, E(): 1.2e-38, (32.2% identity in 537 aa overlap). Also similar to others e.g. Q9HUN7|PA4927 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (830 aa), FASTA scores: opt: 1247, E(): 2.2e-68, (38.25% identity in 831 aa overlap); Q98HG7|MLL2876 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (803 aa), FASTA scores: opt: 937,E(): 1.9e-49, (32.15% identity in 828 aa overlap); CAC47419|SMC04057 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (802 aa),FASTA scores: opt: 900, E(): 3.4e-47, (30.85% identity in 852 aa overlap); etc. And similar to P71732|YO11_MYCTU|Rv2411c|MT2484|MTCY253.09 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (551 aa), FASTA scores: opt: 781, E(): 4.6e-40, (33.75% identity in 495 aa overlap).	X2BLQ4	No	conserved hypotheticals								X2BLQ4	P59974				Rv2567		Rv2567			
NC_002945.3	Mycobrowser_v4	CDS	2859895	2860920	.	-	0	Mb2598c	Mb2598c		CONSERVED HYPOTHETICAL PROTEIN	Mb2598c, -, len: 341 aa. Equivalent to Rv2568c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 341 aa overlap). Conserved hypothetical protein, highly similar (but longer 60 aa) to Q98E75|MLR4376 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (308 aa), FASTA scores: opt: 566,E(): 4.1e-29, (40.2% identity in 291 aa overlap).	X2BKU3	No	conserved hypotheticals								X2BKU3	P65010				Rv2568c		Rv2568c			
NC_002945.3	Mycobrowser_v4	CDS	2860913	2861857	.	-	0	Mb2599c	Mb2599c		CONSERVED HYPOTHETICAL PROTEIN	Mb2599c, -, len: 314 aa. Equivalent to Rv2569c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Conserved hypothetical protein, equivalent to Q9CCT2|ML0508 HYPOTHETICAL PROTEIN from Mycobacterium leprae (313 aa),FASTA scores: opt: 1723, E(): 1.9e-95, (84.4% identity in 301 aa overlap); and some similarity with Q49757|YP69_MYCLE|ML0607|MLCL536.03c|B1937_F2_39 HYPOTHETICAL 31.1 KDA PROTEIN from Mycobacterium leprae (279 aa), FASTA scores: opt: 305, E(): 4.5e-11, (33.0% identity in 300 aa overlap). Also similar to to other hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas aeruginosa (311 aa), FASTA scores: opt: 704, E(): 8.7e-35,(39.7% identity in 320 aa overlap); Q98HG8|MLL2875 from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: opt: 521, E(): 6.5e-24, (35.05% identity in 294 aa overlap); Q9A7W9|CC1600 from Caulobacter crescentus (325 aa), FASTA scores: opt: 510, E(): 3.2e-23, (34.4% identity in 2588 aa overlap); etc. Also some similarity with proteins from Mycobacterium tuberculosis e.g. P71734|Rv2409c|MTCY253.11 CONSERVED HYPOTHETICAL PROTEIN (279 aa), FASTA scores: opt: 312, E(): 1.7e-11, (34.45% identity in 296 aa overlap); and Q50732|Rv2566|MTCY9C4.02 LONG CONSERVED HYPOTHETICAL PROTEIN (1140 aa), FASTA scores: opt: 252, E(): 2.2e-07, (28.9% identity in 315 aa overlap)	X2BLC2	No	conserved hypotheticals								X2BLC2	P0A5G6				Rv2569c		Rv2569c			
NC_002945.3	Mycobrowser_v4	CDS	2861961	2862350	.	+	0	Mb2600	Mb2600		CONSERVED HYPOTHETICAL PROTEIN	Mb2600, -, len: 129 aa. Equivalent to Rv2570, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to Q98GQ7|MLR3218 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (133 aa), FASTA scores: opt: 174, E(): 9.6e-05,(32.25% identity in 124 aa overlap); Q9A390|CC3314 HYPOTHETICAL PROTEIN from Caulobacter crescentus (129 aa),FASTA scores: opt: 155, E(): 0.0017, (33.35% identity in 108 aa overlap); and Q9A2Y0|CC3426 HYPOTHETICAL PROTEIN from Caulobacter crescentus (120 aa), FASTA scores: opt: 144, E(): 0.0083, (32.95% identity in 91 aa overlap).	X2BL39	No	conserved hypotheticals								X2BL39	P65014				Rv2570		Rv2570			
NC_002945.3	Mycobrowser_v4	CDS	2865401	2866231	.	+	0	Mb2603	Mb2603		CONSERVED HYPOTHETICAL PROTEIN	Mb2603, -, len: 275 aa. Equivalent to 2-dehydropantoate 2-reductase from Mycobacterium tuberculosis strain CDC1551 (100% identity with 274 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. Rv2573, len: 246 aa, from Mycobacterium tuberculosis strain H37Rv, Q9ABG6|CC0261 HYPOTHETICAL PROTEIN from Caulobacter crescentus (290 aa),Q99R37|SA2393 HYPOTHETICAL PROTEIN (similar to 2-dehydropantoate 2-reductase) from Staphylococcus aureus subsp. aureus N315 (286 aa), Q9KPQ9|VC2307 2-DEHYDROPANTOATE 2-REDUCTASE from Vibrio cholerae (296 aa). PArt of the Ketopantoate reductase PanE/ApbA superfamily. Mb2603 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BKU7	No									X2BKU7	A0A1R3Y1L0									
NC_002945.3	Mycobrowser_v4	CDS	2866254	2866757	.	+	0	Mb2604	Mb2604		conserved protein	Mb2604, -, len: 167 aa. Equivalent to Rv2574, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Conserved hypothetical protein, showing similarity with Q9K3N3|SCG20A.07 HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218,E(): 2.8e-08, (30.65% identity in 150 aa overlap).	X2BLC4	No	conserved hypotheticals								X2BLC4	P65018				Rv2574		Rv2574			
NC_002945.3	Mycobrowser_v4	CDS	2868366	2868617	.	+	0	Mb2607	Mb2607		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb2607, -, len: 83 aa. Equivalent to 5' end of Rv2577, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 83 aa overlap). Conserved hypothetical protein, showing similarity with various proteins from eukaryotes, in particular phosphatases, e.g. Q9SE01|PAP PURPLE ACID PHOSPHATASE PRECURSOR (EC 3.1.3.2) from Glycine max (Soybean) (464 aa), FASTA scores: opt: 190, E(): 0.00026, (27.3% identity in 388 aa overlap); Q9SVP2|F18A5.90|AT4G13700 HYPOTHETICAL 53.4 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (474 aa), FASTA scores: opt: 280, E(): 6.6e-10,(27.2% identity in 331 aa overlap); Q9FK32 SIMILARITY TO UNKNOWN PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (529 aa), FASTA scores: opt: 249, E(): 6.2e-08,(25.3% identity in 435 aa overlap); Q12546|APHA ACID PHOSPHATASE PRECURSOR from Aspergillus ficuum (614 aa),FASTA scores: opt: 207, E(): 2.9e-05, (22.95% identity in 458 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (g-a) splits Rv2577 into 2 parts,Mb2607 and Mb2608.	Q7TYA4	No								IPR006311	Q7TYA4	A0A1R3Y3P7									
NC_002945.3	Mycobrowser_v4	CDS	2868651	2869955	.	+	0	Mb2608	Mb2608		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb2608, -, len: 434 aa. Equivalent to 3' end of Rv2577, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 434 aa overlap). Conserved hypothetical protein, showing similarity with various proteins from eukaryotes, in particular phosphatases, e.g. Q9SE01|PAP PURPLE ACID PHOSPHATASE PRECURSOR (EC 3.1.3.2) from Glycine max (Soybean) (464 aa), FASTA scores: opt: 190, E(): 0.00026, (27.3% identity in 388 aa overlap); Q9SVP2|F18A5.90|AT4G13700 HYPOTHETICAL 53.4 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (474 aa), FASTA scores: opt: 280, E(): 6.6e-10,(27.2% identity in 331 aa overlap); Q9FK32 SIMILARITY TO UNKNOWN PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (529 aa), FASTA scores: opt: 249, E(): 6.2e-08,(25.3% identity in 435 aa overlap); Q12546|APHA ACID PHOSPHATASE PRECURSOR from Aspergillus ficuum (614 aa),FASTA scores: opt: 207, E(): 2.9e-05, (22.95% identity in 458 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2577 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits Rv2577 into 2 parts, Mb2607 and Mb2608.	Q7TYA3	No								IPR004843,IPR008963	Q7TYA3	A0A1R3Y2F9									
NC_002945.3	Mycobrowser_v4	CDS	2869957	2870979	.	-	0	Mb2609c	Mb2609c		CONSERVED HYPOTHETICAL PROTEIN	Mb2609c, -, len: 340 aa. Equivalent to Rv2578c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Conserved hypothetical protein, highly similar to hypothetical proteins (conserved or not) e.g. Q9ZBJ3|SC9C7.17c from Streptomyces coelicolor (348 aa), FASTA scores: opt: 998,E(): 1.6e-55, (47.6% identity in 355 aa overlap); Q9I763|PA0069 from Pseudomonas aeruginosa (352 aa), FASTA scores: opt: 560, E(): 6e-28, (36.6% identity in 284 aa overlap); Q986C9|MLL7417 from Rhizobium loti (Mesorhizobium loti) (356 aa), FASTA scores: opt: 550,E(): 2.6e-27, (39.15% identity in 240 aa overlap); etc.	X2BLC7,P65024	No	conserved hypotheticals								X2BLC7,P65024	P65024				Rv2578c		Rv2578c			
NC_002945.3	Mycobrowser_v4	CDS	2873537	2874211	.	-	0	Mb2612c	Mb2612c		POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II)	Mb2612c, -, len: 224 aa. Equivalent to Rv2581c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible glyoxalase II (EC 3.1.2.6), equivalent to Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247 HYPOTHETICAL 23.9 KDA PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1264, E(): 7.8e-73, (82.0% identity in 222 aa overlap). Also highly similar to Q9KXP1|SC9C5.33c POSSIBLE HYDROLASE from Streptomyces coelicolor (235 aa), FASTA scores: opt: 654, E(): 2.9e-34,(46.8% identity in 220 aa overlap); and similar to Q9CI24|YFCI HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (210 aa), FASTA scores: opt: 360, E(): 9.9e-16, (35.0% identity in 217 aa overlap); AAK75726|SP1646 METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN from Streptococcus pneumoniae (209 aa), FASTA scores: opt: 320, E(): 3.3e-13, (35.85% identity in 198 aa overlap); AAK80229|CAC2272 PREDICTED ZN-DEPENDENT HYDROLASE OF METALLO-BETA-LACTAMASE SUPERFAMILY from Clostridium acetobutylicum (199 aa),FASTA scores: opt: 282, E(): 8e-11, (32.7% identity in 217 aa overlap); etc. Equivalent to AAK46971 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 22 aa. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS.	X2BLR5,P64262	No	virulence, detoxification, adaptation								X2BLR5,P64262	P64262				Rv2581c		Rv2581c			
NC_002945.3	Mycobrowser_v4	CDS	2878452	2880125	.	-	0	Mb2616c	Mb2616c		POSSIBLE CONSERVED LIPOPROTEIN	Mb2616c, -, len: 557 aa. Equivalent to Rv2585c,len: 557 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 557 aa overlap). Possible conserved lipoprotein precursor, possibly attached to the membrane by a lipid anchor and substrate-binding protein involved in transport, equivalent to Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C2_197 HYPOTHETICAL LIPOPROTEIN PRECURSOR from Mycobacterium leprae (555 aa), FASTA scores: opt: 2812, E(): 9.8e-158,(78.95% identity in 546 aa overlap); and C-terminus highly similar to C-terminus of Q49638|DCIAE|B1177_C1_166 DCIAE PROTEIN from Mycobacterium leprae (344 aa), FASTA scores: opt: 1177, E(): 7.4e-62, (78.6% identity in 229 aa overlap). Also similar in part to various proteins,principally substrate-binding proteins, e.g. O87329|DCIAE DIPEPTIDE-BINDING PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (502 aa), FASTA scores: opt: 614,E(): 1.2e-28, (30.7% identity in 427 aa overlap); Q9AKR0|OPPA|CAC49261 PUTATIVE OLIGOPEPTIDE UPTAKE ABC TRANSPORTER PERIPLASMIC SOLUTE-BINDING PROTEIN PRECURSOR from Rhizobium meliloti (Sinorhizobium meliloti) (532 aa),FASTA scores: opt: 209, E(): 7.7e-05, (22.85% identity in 460 aa overlap); P76128|YDDS_ECOLI|B1487|P77769|P76874 PUTATIVE ABC TRANSPORTER PERIPLASMIC BINDING PROTEIN from Escherichia coli strain K12 (516 aa), FASTA scores: opt: 182, E(): 0.0029, (20.0% identity in 315 aa overlap); etc.	X2BLA5,P59984	No	cell wall and cell processes								X2BLA5,P59984	P59984				Rv2585c		Rv2585c			
NC_002945.3	Mycobrowser_v4	CDS	2916099	2916920	.	+	0	Mb2655	Mb2655		POSSIBLE METHYLTRANSFERASE (METHYLASE)	Mb2655, -, len: 273 aa. Equivalent to Rv2622, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Possible methyltransferase (EC 2.1.1.-), similar in part to others e.g. AAK75664|SP1578 PUTATIVE METHYLTRANSFERASE from Streptococcus pneumoniae (252 aa), FASTA scores: opt: 406,E(): 6.6e-18, (32.65% identity in 251 aa overlap); Q9F8B8 METHYLTRANSFERASE from Streptococcus agalactiae (254 aa),FASTA scores: opt: 381, E(): 2.3e-16, (31.75% identity in 252 aa overlap); Q9RJB6|SCF91.08 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (231 aa),FASTA scores: opt: 159, E(): 0.0091, (33.1% identity in 151 aa overlap); etc. Also similar in part to several hypothetical proteins e.g. Q99YR0|SPY1582 HYPOTHETICAL PROTEIN from Streptococcus pyogenes (251 aa), FASTA scores: opt: 397, E(): 2.3e-17, (36.3% identity in 248 aa overlap).	Q7TY76	No	intermediary metabolism and respiration							IPR013216	Q7TY76	A0A1R3Y1R1				Rv2622		Rv2622			
NC_002945.3	Mycobrowser_v4	CDS	2947718	2948470	.	-	0	Mb2694c	Mb2694c		CONSERVED HYPOTHETICAL PROTEIN	Mb2694c, -, len: 250 aa. Equivalent to Rv2675c,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Conserved hypothetical protein. C-terminus highly similar to Q50010|U1764Z from Mycobacterium leprae (69 aa), FASTA scores: opt: 284, E(): 4.6e-11, (68.25% identity in 63 aa overlap). Shows some similarity with Q9P3V6|SPAC1348.04 (alias Q9P3E7|Q9P7U5) HYPOTHETICAL 16.6 KDA PROTEIN from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 203, E(): 9.5e-06, (33.05% identity in 118 aa overlap); Q9ZSZ7|BMCT METHYL CHLORIDE TRANSFERASE from Batis maritima (230 aa), FASTA scores: opt: 197, E(): 3.3e-05, (28.85% identity in 156 aa overlap); P72459|STSG METHYLTRANSFERASE from Streptomyces griseus (253 aa),FASTA scores: opt: 194, E(): 5.5e-05, (24.45% identity in 229 aa overlap); etc. Also similar to various proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c HYPOTHETICAL 22.8 KDA PROTEIN (212 aa), FASTA scores: opt: 431, E(): 8.3e-20, (39.1% identity in 197 aa overlap); O06426|Rv0560c|MTCY25D10.39c HYPOTHETICAL 25.9 KDA PROTEIN (241 aa), FASTA scores: opt: 379, E(): 1.6e-16, (35.95% identity in 178 aa overlap); O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE (233 aa), FASTA scores: opt: 297, E(): 2e-11, (30.55% identity in 193 aa overlap); etc.	Q7TY49	No	conserved hypotheticals							IPR013216	Q7TY49	A0A1R3Y1V7				Rv2675c		Rv2675c			
NC_002945.3	Mycobrowser_v4	CDS	3437998	3439245	.	+	0	Mb3142	Mb3142		PROBABLE TRANSPOSASE	Mb3142, -, len: 415 aa. Equivalent to Rv3115, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 415 aa overlap). Probable IS1081 transposase, similar to others. Has transposases, mutator family, signature (PS01007). Other copies are MTCY10G2.02c, MTCY441.35, MTCY77.03c.	X2BGW7,P60231	No	insertion seqs and phages								X2BGW7,P60231	P60231				Rv3115		Rv3115			
NC_002945.3	Mycobrowser_v4	CDS	2894934	2895365	.	+	0	Mb2630	Mb2630		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb2630, -, len: 143 aa. Equivalent to Rv2599, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 143 aa overlap). Probable conserved membrane protein, equivalent to Q9K536|2599 HYPOTHETICAL 15.0 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (143 aa), FASTA scores: opt: 691, E(): 1.7e-33, (68.55% identity in 143 aa overlap). Shows weak similarity with Q9L089|SCC24.28c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (131 aa), FASTA scores: opt: 130,E(): 0.52, (26.45% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.	Q7TY96	No	cell wall and cell processes							IPR025341	Q7TY96	A0A1R3Y235				Rv2599		Rv2599			
NC_002945.3	Mycobrowser_v4	CDS	2895447	2895848	.	+	0	Mb2631	Mb2631		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2631, -, len: 133 aa. Equivalent to Rv2600, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable conserved integral membrane protein, equivalent (but shorter 18 aa) to Q9K537|YQ00_MYCPA HYPOTHETICAL PROTEIN RV2600 HOMOLOG from Mycobacterium paratuberculosis (151 aa), FASTA scores: opt: 543, E(): 4.2e-28, (62.9% identity in 132 aa overlap). Also some similarity with other hypothetical or membrane proteins e.g. Q9L090|SCC24.27c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (146 aa),FASTA scores: opt: 241, E(): 8.7e-09, (34.8% identity in 135 aa overlap); O58487|PH0773 HYPOTHETICAL 15.0 KDA PROTEIN from Pyrococcus horikoshii (138 aa), FASTA scores: opt: 116, E(): 0.84, (34.35% identity in 96 aa overlap); etc. Equivalent to AAK46990 from Mycobacterium tuberculosis strain CDC1551 (152 aa) but shorter 19 aa.	X2BLC5,P68914	No	cell wall and cell processes								X2BLC5,P68914	P68914				Rv2600		Rv2600			
NC_002945.3	Mycobrowser_v4	CDS	2924356	2924895	.	+	0	Mb2663	Mb2663		HYPOTHETICAL PROTEIN	Mb2663, -, len: 179 aa. Equivalent to Rv2630, len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Hypothetical unknown protein.	Q7TY68	No	conserved hypotheticals							IPR023572	Q7TY68	A0A1R3Y1S0				Rv2630		Rv2630			
NC_002945.3	Mycobrowser_v4	CDS	4055877	4056038	.	-	0	Mb3703c	Mb3703c		CONSERVED HYPOTHETICAL PROTEIN	Mb3703c, -, len: 53 aa. Equivalent to Rv3678A, len: 53 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 53 aa overlap). Conserved hypothetical protein, similar to SCH17.10|AL079353_10 conserved hypothetical protein from Streptomyces coelicolor (53 aa),FASTA scores: opt: 259, E(): 1.5e-13, (78.0% identity in 50 aa overlap).	Q7TVY6	No	conserved hypotheticals							IPR025234	Q7TVY6	A0A1R3Y4V1				Rv3678A		Rv3678A			
NC_002945.3	Mycobrowser_v4	CDS	3008255	3008428	.	+	0	Mb2757	Mb2757		CONSERVED HYPOTHETICAL CYSTEINE RICH PROTEIN (FRAGMENT)	Mb2757, -, len: 57 aa. Equivalent to Rv2737A, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Conserved hypothetical cys-rich protein (possibly gene fragment), similar to central part of AJ243803_1|glgA from Streptomyces coelicolor glgA (181 aa), FASTA scores: opt: 210, E(): 6.1e-09, (59.25% identity in 54 aa overlap).	Q7TY03	No	conserved hypotheticals							IPR024726	Q7TY03	A0A1R3Y418				Rv2737A		Rv2737A			
NC_002945.3	Mycobrowser_v4	CDS	2898262	2899017	.	-	0	Mb2635c	Mb2635c		highly conserved protein	Mb2635c, -, len: 251 aa. Equivalent to Rv2603c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Highly conserved hypothetical protein, equivalent to Q49645|YQ03_MYCLE|ML0475|U1177B|B1177_C2_181 HYPOTHETICAL 26.6 KDA PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 1514, E(): 2.2e-84, (92.45% identity in 251 aa overlap). Also highly similar to Q9L288|SCL2.11c HYPOTHETICAL 26.8 KDA PROTEIN from Streptomyces coelicolor (250 aa), FASTA scores: opt: 1268, E(): 1.5e-69, (76.7% identity in 249 aa overlap); Q9AE12|YFCA HYPOTHETICAL STRUCTURAL PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (251 aa), FASTA scores: opt: 1231,E(): 2.6e-67, (72.9% identity in 251 aa overlap); O83487|Y474_TREPA|TP0474 HYPOTHETICAL PROTEIN from Treponema pallidum (245 aa), FASTA scores: opt: 780, E(): 4.4e-40, (47.75% identity in 245 aa overlap); P24237|YEBC_ECOLI|B1864 PROTEIN YEBC from Escherichia coli strain K12 (246 aa), FASTA scores: opt: 776, E(): 7.6e-40,(47.8% identity in 249 aa overlap); etc.	X2BL55,P67178	No	conserved hypotheticals								X2BL55,P67178	P67178				Rv2603c		Rv2603c			
NC_002945.3	Mycobrowser_v4	CDS	3256659	3257258	.	-	0	Mb2973c	Mb2973c		chorismate pyruvate lyase	Mb2973c, -, len: 199 aa. Equivalent to Rv2949c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Conserved hypothetical protein, equivalent to Q9CD83|ML0133 HYPOTHETICAL PROTEIN from Mycobacterium leprae (210 aa),FASTA scores: opt: 797, E(): 7.4e-47, (62.55% identity in 195 aa overlap). Equivalent to AAK47348 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 13 aa.	X2BMN6,Q7TXK6	No	intermediary metabolism and respiration								X2BMN6,Q7TXK6	Q7TXK6				Rv2949c		Rv2949c			
NC_002945.3	Mycobrowser_v4	CDS	2904267	2905322	.	-	0	Mb2641c	Mb2641c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb2641c, -, len: 351 aa. Equivalent to Rv2609c,len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 351 aa overlap). Probable conserved membrane protein, equivalent to O07146|MLCL581.13c|ML0451 HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium leprae (349 aa), FASTA scores: opt: 1675, E(): 1.4e-95, (77.85% identity in 334 aa overlap). Also similar to hypothetical proteins: O69888|SC2E1.17|MUTT HYPOTHETICAL 19.4 KDA PROTEIN from Streptomyces coelicolor and Streptomyces lividans (172 aa), FASTA scores: opt: 345, E(): 3.5e-14,(44.7% identity in 161 aa overlap); Q9L285|SCL2.14c HYPOTHETICAL 19.8 KDA PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 179, E(): 0.00056, (43.25% identity in 171 aa overlap); and Q9RYE5|DR0004 MUTT/NUDIX FAMILY PROTEIN from Deinococcus radiodurans (350 aa),FASTA scores: opt: 153, E(): 0.037, (33.35% identity in 123 aa overlap). Contains PS00893 mutT domain signature. BELONGS TO THE MUTT/NUDIX FAMILY.	Q7TY89	No	cell wall and cell processes							IPR000086,IPR015797,IPR020084	Q7TY89	A0A1R3Y1P9				Rv2609c		Rv2609c			
NC_002945.3	Mycobrowser_v4	CDS	3282623	3282793	.	+	0	Mb2995	Mb2995		CONSERVED HYPOTHETICAL PROTEIN	Mb2995, -, len: 56 aa. Equivalent to Rv2970A, len: 56 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 56 aa overlap). Conserved hypothetical protein, similar to C-terminal part of several oxidoreductases e.g. Rv2971|Z83018|MTCY349_22 from Mycobacterium tuberculosis (282 aa), FASTA scores: opt: 158, E(): 3.6e-06, (45.0% identity in 60 aa overlap). May represent a gene fragment.	X2BM17	No	conserved hypotheticals								X2BM17	A0A1R3Y350				Rv2970A		Rv2970A			
NC_002945.3	Mycobrowser_v4	CDS	2906469	2907419	.	-	0	Mb2643c	Mb2643c		probable acyltransferase	Mb2643c, -, len: 316 aa. Equivalent to Rv2611c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 316 aa overlap). Probable acyltransferase (EC 2.3.1.-) , equivalent to O07148|MLCL581.15c|ML0453 HYPOTHETICAL 35.4 KDA PROTEIN from Mycobacterium leprae (320 aa), FASTA scores: opt: 1529, E(): 5e-90, (71.45% identity in 312 aa overlap); and equivalent to Q9F7Y8 PUTATIVE ACYLTRANSFERASE from Mycobacterium smegmatis (303 aa), FASTA scores: opt: 1464,E(): 6.5e-86, (72.15% identity in 291 aa overlap) (see citation below). Also highly similar to Q9L283|SCL2.16c PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (311 aa), FASTA scores: opt: 810, E(): 2.8e-44, (47.7% identity in 302 aa overlap); and similar to other acyltransferases e.g. Q9F0N3 ACYLTRANSFERASE from Campylobacter jejuni (295 aa), FASTA scores: opt: 207, E(): 6.4e-06, (20.45% identity in 220 aa overlap); Q9K379 ACYLTRANSFERASE (LIPID A BIOSYNTHESIS ACYLTRANSFERASE) from Campylobacter jejuni (295 aa), FASTA scores: opt: 203, E(): 1.1e-05, (20.0% identity in 220 aa overlap); etc.	Q7TY87	No	lipid metabolism							IPR004960	Q7TY87	A0A1R3Y1Q0				Rv2611c		Rv2611c			
NC_002945.3	Mycobrowser_v4	CDS	2913313	2913753	.	-	0	Mb2650c	Mb2650c		PROBABLE TRANSMEMBRANE PROTEIN	Mb2650c, -, len: 146 aa. Equivalent to Rv2617c,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Probable transmembrane protein, showing some similarity to hypothetical or membrane proteins e.g. CAC47207|SMC00744 PUTATIVE TRANSPORT PROTEIN TRANSMEMBRANE from Rhizobium meliloti (Sinorhizobium meliloti) (399 aa), FASTA scores: opt: 108, E(): 5.5, (29.15% identity in 144 aa overlap).	Q7TY81	No	cell wall and cell processes							IPR011637	Q7TY81	A0A1R3Y256				Rv2617c		Rv2617c			
NC_002945.3	Mycobrowser_v4	CDS	2912796	2913296	.	+	0	Mb2649	Mb2649		conserved protein	Mb2649, -, len: 166 aa. Equivalent to Rv2616, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 166 aa overlap). Conserved hypothetical protein, highly similar to bacterial proteins: Q9L1G0|SC3D11.02c HYPOTHETICAL 20.3 KDA PROTEIN from Streptomyces coelicolor (188 aa), FASTA scores: opt: 407,E(): 2.3e-20, (44.0% identity in 159 aa overlap); Q9X945 A3(2) GLYCOGEN METABOLISM CLUSTER from Streptomyces coelicolor (134 aa), FASTA scores: opt: 330, E(): 2.5e-15,(46.65% identity in 120 aa overlap) (N-terminus shorter); Q9RST8|DR2035 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (198 aa), FASTA scores: opt: 228,E(): 2.4e-08, (35.1% identity in 168 aa overlap).	Q7TY82	No	conserved hypotheticals							IPR014457,IPR018960	Q7TY82	A0A1R3Y1Y9				Rv2616		Rv2616			
NC_002945.3	Mycobrowser_v4	CDS	2908066	2908653	.	-	0	Mb2645c	Mb2645c		conserved protein	Mb2645c, -, len: 195 aa. Equivalent to Rv2613c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). Conserved hypothetical protein, equivalent to Q9CCU0|ML0455 HYPOTHETICAL PROTEIN from Mycobacterium leprae (206 aa),FASTA scores: opt: 1074, E(): 7.4e-62, (84.7% identity in 196 aa overlap); and highly similar, but longer 18 aa, to O07150|MLCL581.17c HYPOTHETICAL 20.7 KDA PROTEIN from Mycobacterium leprae (186 aa), FASTA scores: opt: 1038,E(): 1.4e-59, (89.7% identity in 175 aa overlap). Also highly similar to other hypothetical proteins (often Hit family member) e.g. Q9F7Z0 from Mycobacterium smegmatis (see citation below) (205 aa), FASTA scores: opt: 975,E(): 1.6e-55, (79.35% identity in 184 aa overlap); Q9L279|SCL2.20 from Streptomyces coelicolor (186 aa),FASTA scores: opt: 638, E(): 5.8e-34, (52.85% identity in 176 aa overlap); Q9YFX8|APE0122 from Aeropyrum pernix (184 aa), FASTA scores: opt: 515, E(): 4.4e-26, (45.9% identity in 159 aa overlap); etc. It seems the Rv2613c and downstream ORF Rv2612c|psgA1 are expressed from the same promoter (see citation below) and that Rv2613c should be involved in lipid metabolism.	Q7TY85	No	lipid metabolism							IPR001310,IPR011146	Q7TY85	A0A1R3Y1Q2				Rv2613c		Rv2613c			
NC_002945.3	Mycobrowser_v4	CDS	2910833	2911060	.	+	0	Mb2647	Mb2647		CONSERVED HYPOTHETICAL PROTEIN	Mb2647, -, len: 75 aa. Equivalent to Rv2614A, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 75 aa overlap). Conserved hypothetical protein. The region from aa 10-35 is similar to part of C-terminal part of several TRIOSEPHOSPHATE ISOMERASES (EC 5.3.1.1) e.g. P46711|TPIS_MYCLE|TPIA|TPI|ML0572|B1496_C1_127 from Mycobacterium leprae (261 aa), FASTA scores: opt: 112,E(): 0.95, (60.0% identity in 25 aa overlap); and O08408|TPIS_MYCTU|TPIA|TPI|Rv1438|MT1482|MTCY493.16c from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 104, E(): 3.3, (60.0% identity in 25 aa overlap); P19583|TPIS_CORGL|TPIA|TPI from Corynebacterium glutamicum (Brevibacterium flavum) (259 aa), FASTA scores: opt: 100,E(): 6, (45.45% identity in 33 aa overlap); etc. TRIOSEPHOSPHATE ISOMERASES PLAY AN IMPORTANT ROLE IN SEVERAL METABOLIC PATHWAYS (CATALYTIC ACTIVITY: D-GLYCERALDEHYDE 3-PHOSPHATE = DIHYDROXY-ACETONE PHOSPHATE).	Q7TY84	No	conserved hypotheticals								Q7TY84	A0A1R3Y3T9				Rv2614A		Rv2614A			
NC_002945.3	Mycobrowser_v4	CDS	2913900	2914577	.	+	0	Mb2651	Mb2651		CONSERVED HYPOTHETICAL PROTEIN	Mb2651, -, len: 225 aa. Equivalent to Rv2618, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Conserved hypothetical protein, similar in part to Q9EWQ9|SC4C2.03 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (159 aa), FASTA scores: opt: 235, E(): 1.3e-07,(43.7% identity in 103 aa overlap); Q9HLM6|TA0201 HYPOTHETICAL PROTEIN from Thermoplasma acidophilum (215 aa), FASTA scores: opt: 164, E(): 0.0038, (23.4% identity in 201 aa overlap); and to mycobacterial proteins e.g. O06191|Rv2621c|MTCY01A10.11 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium tuberculosis (224 aa), FASTA scores: opt: 149, E(): 0.033, (28.05% identity in 196 aa overlap).	Q7TY80	No	conserved hypotheticals							IPR011991	Q7TY80	A0A1R3Y1Q9				Rv2618		Rv2618			
NC_002945.3	Mycobrowser_v4	CDS	2914562	2914915	.	-	0	Mb2652c	Mb2652c		conserved protein	Mb2652c, -, len: 117 aa. Equivalent to Rv2619c,len: 117 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 117 aa overlap). Conserved hypothetical protein, highly similar to Q9L0F3|SCD31.14 HYPOTHETICAL 11.6 KDA PROTEIN from Streptomyces coelicolor (110 aa) , FASTA scores: opt: 407, E(): 2.3e-21, (55.95% identity in 109 aa overlap). Also similarity with other short bacterial hypothetical proteins e.g. Q9F8B9 HYPOTHETICAL 12.4 KDA PROTEIN from Streptococcus agalactiae (112 aa), FASTA scores: opt: 143, E(): 0.0032,(32.45% identity in 74 aa overlap); etc.	Q7TY79	No	conserved hypotheticals							IPR011051,IPR013096,IPR014710	Q7TY79	A0A1R3Y1R7				Rv2619c		Rv2619c			
NC_002945.3	Mycobrowser_v4	CDS	2914928	2915353	.	-	0	Mb2653c	Mb2653c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2653c, -, len: 141 aa. Equivalent to Rv2620c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Probable conserved transmembrane protein, highly similar to O54184|SC7H1.25 HYPOTHETICAL 14.6 KDA PROTEIN from Streptomyces coelicolor (144 aa), FASTA scores: opt: 459, E(): 1.4e-22, (56.45% identity in 140 aa overlap).	Q7TY78	No	cell wall and cell processes								Q7TY78	A0A1R3Y1R0				Rv2620c		Rv2620c			
NC_002945.3	Mycobrowser_v4	CDS	2915350	2916021	.	-	0	Mb2654c	Mb2654c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb2654c, -, len: 223 aa. Equivalent to Rv2621c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Possible transcriptional regulator, similar in part to Q49688|MLCL536.29c|ML0592 PUTATIVE DNA-BINDING PROTEIN from Mycobacterium leprae (254 aa), FASTA scores: opt: 168, E(): 0.0018, (29.75% identity in 222 aa overlap). Shows similarity with Q9XAD0|SCC22.08c PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (252 aa),FASTA scores: opt: 148, E(): 0.032, (29.4% identity in 204 aa overlap); and Q9RVM8|DR0999 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (225 aa), FASTA scores: opt: 195, E(): 3.3e-05, (29.6% identity in 213 aa overlap). Also some similarity with O06195|Rv2618|MTCY01A10.15c from Mycobacterium tuberculosis (225 aa), FASTA scores: opt: 149, E(): 0.025,(28.95% identity in 197 aa overlap). Contains helix-turn-helix motif at aa 31-52 (Score 1662, +4.85 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (ggg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa).	Q7TY77	No	regulatory proteins							IPR011991	Q7TY77	A0A1R3Y1R6				Rv2621c		Rv2621c			
NC_002945.3	Mycobrowser_v4	CDS	2920970	2922211	.	-	0	Mb2660c	Mb2660c		conserved protein	Mb2660c, -, len: 413 aa. Equivalent to Rv2627c,len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 413 aa overlap). Conserved hypothetical protein. Some similarity in C-terminal part of O53697|Rv0293c|MTV035.21c HYPOTHETICAL 44.0 KDA PROTEIN from Mycobacterium tuberculosis (400 aa), FASTA scores: opt: 392, E(): 1.9e-17, (31.1% identity in 299 aa overlap).	Q7TY71	No	conserved hypotheticals								Q7TY71	A0A1R3Y265				Rv2627c		Rv2627c			
NC_002945.3	Mycobrowser_v4	CDS	2970809	2971294	.	+	0	Mb2717	Mb2717		PROBABLE CONSERVED ALANINE RICH TRANSMEMBRANE PROTEIN	Mb2717, -, len: 161 aa. Equivalent to Rv2698, len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I POSSIBLE MEMBRANE PROTEIN from Mycobacterium leprae (157 aa), FASTA scores: opt: 886,E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also similar to O54132|SC2E9.07c HYPOTHETICAL 16.5 KDA PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 230, E(): 7.1e-08, (35.7% identity in 154 aa overlap).	Q7TY30	No	cell wall and cell processes							IPR021443	Q7TY30	A0A1R3Y3X7				Rv2698		Rv2698			
NC_002945.3	Mycobrowser_v4	CDS	2917952	2918770	.	-	0	Mb2657c	Mb2657c		universal stress protein family protein	Mb2657c, -, len: 272 aa. Equivalent to Rv2624c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, similar to several Streptomyces proteins e.g. Q9RIY5|SCJ1.29c HYPOTHETICAL 30.1 KDA PROTEIN from Streptomyces coelicolor (283 aa), FASTA scores: opt: 260, E(): 5e-09, (32.05% identity in 290 aa overlap). Also similar to Mycobacterium tuberculosis proteins O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 563, E(): 7e-28, (36.85% identity in 266 aa overlap); P95192|Rv3134c|MTCY03A2.240 (268 aa), FASTA scores: opt: 458, E(): 2.3e-21, (36.55% identity in 271 aa overlap); Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA scores: opt: 199, E(): 3.2e-05, (29.35% identity in 286 aa overlap); etc.	Q7TY74	No	virulence, detoxification, adaptation							IPR006015,IPR006016,IPR014729	Q7TY74	A0A1R3Y3U4				Rv2624c		Rv2624c			
NC_002945.3	Mycobrowser_v4	CDS	2918785	2919966	.	-	0	Mb2658c	Mb2658c		PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN	Mb2658c, -, len: 393 aa. Equivalent to Rv2625c,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Probable conserved transmembrane ala-, leu-rich protein, similar to many hypothetical or membrane proteins e.g. Q55518|Y528_SYNY3|SLL0528 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (379 aa),FASTA scores: opt: 552, E(): 5.6e-26, (30.75% identity in 374 aa overlap); Q9RJ56|SCI41.35c HYPOTHETICAL 39.8 KDA PROTEIN from Streptomyces coelicolor (374 aa), FASTA scores: opt: 419, E(): 5.7e-18, (31.6% identity in 383 aa overlap); CAC49448|SMB20925 CONSERVED HYPOTHETICAL MEMBRANE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (372 aa), FASTA scores: opt: 401, E(): 6.9e-17,(29.5% identity in 383 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.	Q7TY73	No	cell wall and cell processes							IPR000644,IPR008915,IPR016483	Q7TY73	A0A1R3Y2K2				Rv2625c		Rv2625c			
NC_002945.3	Mycobrowser_v4	CDS	2925034	2926332	.	+	0	Mb2664	Mb2664		CONSERVED HYPOTHETICAL PROTEIN	Mb2664, -, len: 432 aa. Equivalent to Rv2631, len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Conserved hypothetical protein, highly similar to several conserved hypothetical proteins from various species e.g. O29399|AF0862 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (482 aa), FASTA scores: opt: 1496,E(): 2.1e-80, (52.3% identity in 438 aa overlap) (has its N-terminus longer 38 aa); O27634|MTH1597 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (488 aa),FASTA scores: opt: 1428, E(): 2.1e-76, (50.9% identity in 438 aa overlap); Q9YB37|APE1758 HYPOTHETICAL 53.7 KDA PROTEIN APE1758 from Aeropyrum pernix (483 aa), FASTA scores: opt: 1422, E(): 4.6e-76, (49.3% identity in 440 aa overlap) (has its N-terminus longer 38 aa); etc. Equivalent to AAK47022 from Mycobacterium tuberculosis strain CDC1551 (432 aa) but longer 8 aa. 3' part extended since first submission (+175 aa).	X2BLH6,P59975	No	conserved hypotheticals								X2BLH6,P59975	P59975				Rv2631		Rv2631			
NC_002945.3	Mycobrowser_v4	CDS	2926371	2926652	.	-	0	Mb2665c	Mb2665c		conserved protein	Mb2665c, -, len: 93 aa. Equivalent to Rv2632c, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis: P71996|YH38_MYCTU|Rv1738|MT1780|MTCY04C12.23 (94 aa),FASTA scores: opt: 319, E(): 4.2e-15, (53.95% identity in 89 aa overlap); and Q9KK61 from Mycobacterium bovis BCG (56 aa), FASTA scores: opt: 178, E(): 9.2e-06, (52.95% identity in 51 aa overlap).	X2BL77	No	conserved hypotheticals								X2BL77	P65034				Rv2632c		Rv2632c			
NC_002945.3	Mycobrowser_v4	CDS	2929932	2930174	.	+	0	Mb2668	Mb2668		HYPOTHETICAL PROTEIN	Mb2668, -, len: 80 aa. Equivalent to Rv2635, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Hypothetical unknown protein.	X2BL23	No	conserved hypotheticals								X2BL23	P65038				Rv2635		Rv2635			
NC_002945.3	Mycobrowser_v4	CDS	2930175	2930852	.	+	0	Mb2669	Mb2669		CONSERVED HYPOTHETICAL PROTEIN	Mb2669, -, len: 225 aa. Equivalent to Rv2636, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Conserved hypothetical protein, showing some similarity with various proteins: Q98FG2|MLL3789 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (239 aa), FASTA scores: opt: 304, E(): 3.7e-13, (31.55% identity in 187 aa overlap); CAC46568|SMC04451 PUTATIVE CHLORAMPHENICOL PHOSPHOTRANSFERASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (220 aa), FASTA scores: opt: 175,E(): 0.00014, (28.0% identity in 225 aa overlap); Q56148|CPT_STRVL CHLORAMPHENICOL 3-O PHOSPHOTRANSFERASE (EC 2.7.1.-) from Streptomyces violaceus (Streptomyces venezuelae) (178 aa), FASTA scores: opt: 131, E(): 0.1,(31.75% identity in 170 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Translational start site uncertain, chosen by similarity.	X2BLI1,P65040	No	conserved hypotheticals								X2BLI1,P65040	P65040				Rv2636		Rv2636			
NC_002945.3	Mycobrowser_v4	CDS	2931867	2932313	.	+	0	Mb2671	Mb2671		CONSERVED HYPOTHETICAL PROTEIN	Mb2671, -, len: 148 aa. Equivalent to Rv2638, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Conserved hypothetical protein, similar in part to Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa), FASTA scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa overlap); and showing weak similarity with various proteins e.g. O69205 HYPOTHETICAL 13.4 KDA PROTEIN from Actinosynnema pretiosum (subsp. auranticum) (128 aa),FASTA scores: opt: 157, E(): 0.0016, (29.8% identity in 114 aa overlap); Q9RJ93|SCF91.32 PUTATIVE ANTI-SIGMA FACTOR ANTAGONIST from Streptomyces coelicolor (183 aa),FASTA scores: opt: 148, E(): 0.0082, (30.85% identity in 107 aa overlap); etc. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis: O07728|Rv1904|MTCY180.14c (143 aa), FASTA scores: opt: 456, E(): 3.9e-23, (52.8% identity in 125 aa overlap); and Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128 aa),FASTA scores: opt: 435, E(): 8.6e-22, (53.6% identity in 125 aa overlap).	Q7TY67	No	conserved hypotheticals							IPR002645,IPR003658	Q7TY67	A0A1R3Y1T2				Rv2638		Rv2638			
NC_002945.3	Mycobrowser_v4	CDS	2932488	2932820	.	-	0	Mb2672c	Mb2672c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2672c, -, len: 110 aa. Equivalent to Rv2639c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Probable conserved integral membrane protein, highly similar to many bacterial hypothetical or membrane proteins e.g. Q9X889|YE14_STRCO|SCE15.14 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 597, E(): 3.1e-31, (73.15% identity in 108 aa overlap); Q55939|Y793_SYNY3|SLL0793 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (108 aa), FASTA scores: opt: 341, E(): 4.9e-15, (51.4% identity in 109 aa overlap); O31553|YFJF_BACSU POTENTIAL INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (109 aa),FASTA scores: opt: 334, E(): 1.4e-14, (47.5% identity in 109 aa overlap); etc.	X2BLX0,P67147	No	cell wall and cell processes								X2BLX0,P67147	P67147				Rv2639c		Rv2639c			
NC_002945.3	Mycobrowser_v4	CDS	2932940	2933299	.	-	0	Mb2673c	Mb2673c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY)	Mb2673c, -, len: 119 aa. Equivalent to Rv2640c,len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 aa), FASTA scores: opt: 261, E(): 5.6e-10, (47.75% identity in 103 aa overlap); Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (122 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity in 116 aa overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity in 116 aa overlap); P77295|YGAV_ECOLI|B2667 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 (99 aa), FASTA scores: opt: 156, E(): 0.0023, (34.1% identity in 88 aa overlap); etc. Also similar to upstream ORF P71941|Rv2642|MTCY441.12 PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (126 aa), FASTA scores: opt: 237, E(): 2e-08,(38.55% identity in 109 aa overlap). Contains helix-turn-helix motif at aa 59-80 (Score 1166, +3.16 SD). BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TY66	No	regulatory proteins							IPR001845,IPR011991	Q7TY66	A0A1R3Y1T4				Rv2640c		Rv2640c			
NC_002945.3	Mycobrowser_v4	CDS	2971299	2971601	.	-	0	Mb2718c	Mb2718c		CONSERVED HYPOTHETICAL PROTEIN	Mb2718c, -, len: 100 aa. Equivalent to Rv2699c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Conserved hypothetical protein, very equivalent to Q49990|ML1026|U1764J HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 632,E(): 7.7e-36, (96.0% identity in 100 aa overlap). Also highly similar to O54130|SC2E9.05 HYPOTHETICAL 11.0 KDA PROTEIN from Streptomyces coelicolor (98 aa), FASTA scores: opt: 465, E(): 1.1e-24, (71.45% identity in 98 aa overlap).	Q7TY29	No	conserved hypotheticals							IPR025242	Q7TY29	A0A1R3Y2R7				Rv2699c		Rv2699c			
NC_002945.3	Mycobrowser_v4	CDS	2933995	2934375	.	+	0	Mb2675	Mb2675		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY)	Mb2675, -, len: 126 aa. Equivalent to Rv2642, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (122 aa), FASTA scores: opt: 390, E(): 3.7e-19, (56.55% identity in 122 aa overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa),FASTA scores: opt: 378, E(): 2.3e-18, (59.8% identity in 97 aa overlap); Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 aa), FASTA scores: opt: 359, E(): 4.1e-17, (56.9% identity in 116 aa overlap); P52144|ARR2_ECOLI|ARSR from Escherichia coli (117 aa), FASTA scores: opt: 202, E(): 1e-06, (39.8% identity in 88 aa overlap); etc. Also similar to downstream ORF P71939|Rv2640c|MTCY441.10c PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (119 aa), FASTA scores: opt: 237, E(): 5e-09, (38.55% identity in 109 aa overlap); and others from Mycobacterium tuberculosis e.g. O05840|Rv2358|MTCY27.22c. Contains PS00846 Bacterial regulatory proteins, arsR family signature. Contains helix-turn-helix motif at aa 58-79 (Score 1112, +2.97 SD). BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TY65	No	regulatory proteins							IPR001845,IPR011991,IPR018334	Q7TY65	A0A1R3Y1T1				Rv2642		Rv2642			
NC_002945.3	Mycobrowser_v4	CDS	2939550	2940353	.	+	0	Mb2685	Mb2685		probable transposase for insertion sequence element is1081 (fragment)	Mb2685, -, len: 267 aa. Equivalent to Rv2666, len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 267 aa overlap). Transposase (fragment), identical in region of overlap to P35882|TRA1_MYCBO|TRA1_MYCTU TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081 from Mycobacterium tuberculosis or bovis (415 aa). Last 4 codons not part of gene. Contains PS01007 Transposases, Mutator family, signature.	Q7TY56	No	insertion seqs and phages							IPR001207	Q7TY56	A0A1R3Y1U2				Rv2666		Rv2666			
NC_002945.3	Mycobrowser_v4	CDS	2935995	2936312	.	-	0	Mb2677c	Mb2677c		HYPOTHETICAL PROTEIN	Mb2677c, -, len: 105 aa. Equivalent to Rv2644c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Hypothetical unknown protein.	X2BLX4	No	conserved hypotheticals								X2BLX4	P65042				Rv2644c		Rv2644c			
NC_002945.3	Mycobrowser_v4	CDS	2939178	2939459	.	+	0	Mb2684	Mb2684		HYPOTHETICAL ARGININE RICH PROTEIN	Mb2684, -, len: 93 aa. Equivalent to Rv2665, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Hypothetical arg-rich protein, showing some similarity to N-terminus of P71640|Rv2811|MTCY16B7.32c HYPOTHETICAL 21.1 KDA PROTEIN from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 157, E(): 0.0011, (37.5% identity in 72 aa overlap); and also to part of O35132|CP2B_RAT|CYP27B1|CYP27B 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus (Rat) (501 aa), FASTA scores: opt: 106, E(): 5.4, (34.5% identity in 87 aa overlap).	Q7TY57	No	conserved hypotheticals								Q7TY57	A0A1R3Y1U4				Rv2665		Rv2665			
NC_002945.3	Mycobrowser_v4	CDS	2978475	2978921	.	+	0	Mb2728	Mb2728		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2728, -, len: 148 aa. Equivalent to Rv2709, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 148 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CCB4|ML1015 (alias Q49983|U1764B but extended in N-terminus) POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (139 aa), FASTA scores: opt: 578, E(): 5.5e-31, (70.75% identity in 123 aa overlap). Shows also similarity with Q9RJ48|SCI8.05 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (159 aa), FASTA scores: opt: 119,E(): 0.57, (31.95% identity in 119 aa overlap).	Q7TY21	No	cell wall and cell processes							IPR021449	Q7TY21	A0A1R3Y2S7				Rv2709		Rv2709			
NC_002945.3	Mycobrowser_v4	CDS	2941212	2941733	.	+	0	Mb2687	Mb2687		POSSIBLE EXPORTED ALANINE AND VALINE RICH PROTEIN	Mb2687, -, len: 173 aa. Equivalent to Rv2668, len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 173 aa overlap). Hypothetical ala-,val-rich protein, possibly exported. Equivalent to AAK47057 from Mycobacterium tuberculosis strain CDC1551 (208 aa) but N-terminal part shorter 35 aa and with few differences. Has potential signal peptide sequence.	Q7TY55	No	cell wall and cell processes								Q7TY55	A0A1R3Y3V8				Rv2668		Rv2668			
NC_002945.3	Mycobrowser_v4	CDS	2941762	2942232	.	+	0	Mb2688	Mb2688		gcn5-related n-acetyltransferase	Mb2688, -, len: 156 aa. Equivalent to Rv2669, len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, showing some similarity to various proteins e.g. Q9A6M0|CC2073 ACETYLTRANSFERASE (GNAT FAMILY) from Caulobacter crescentus (178 aa), FASTA scores: opt: 242, E(): 1.2e-09, (30.9% identity in 165 aa overlap); Q99RQ8|SA2159 hypothetical protein similar to transcription repressor of sporulation, septation and degradation paiA from Staphylococcus aureus subsp. aureus N315 (171 aa), FASTA scores: opt: 214, E(): 9.8e-08,(27.5% identity in 160 aa overlap); BAB58531|SAV2369 HYPOTHETICAL 20.1 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (171 aa), FASTA scores: opt: 214, E(): 9.8e-08, (27.5% identity in 160 aa overlap); P21340|PAIA_BACSU|O32112 PROTEASE SYNTHASE AND SPORULATION from Bacillus subtilis (171 aa), FASTA scores: opt: 209,E(): 2.1e-07, (22.85% identity in 162 aa overlap); etc.	X2BL47,P63426	No	intermediary metabolism and respiration								X2BL47,P63426	P63426				Rv2669		Rv2669			
NC_002945.3	Mycobrowser_v4	CDS	2942210	2943319	.	-	0	Mb2689c	Mb2689c		CONSERVED HYPOTHETICAL PROTEIN	Mb2689c, -, len: 369 aa. Equivalent to Rv2670c,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Conserved hypothetical protein, equivalent, but longer 164 aa, to O05683|MLC1351.22c HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 847,E(): 1.2e-45, (82.4% identity in 159 aa overlap). And highly similar to Q9X824|SC9B1.04c PUTATIVE ATP/GTP-BINDING INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (350 aa), FASTA scores: opt: 1169,E(): 2e-65, (56.85% identity in 343 aa overlap); and Q9RWB0|DR0759 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (351 aa), FASTA scores: opt: 859,E(): 4e-46, (45.9% identity in 331 aa overlap). Also some similarity with other proteins e.g. P46442|YHCM_ECOLI|AAG58360|BAB37528 HYPOTHETICAL PROTEIN from Escherichia coli strains K12 and O157:H7 (375 aa),FASTA scores: opt: 237, E(): 2.1e-07, (28.0% identity in 325 aa overlap); Q9JRK2|NMA1520|NMB1306 PUTATIVE NUCLEOTIDE-BINDING PROTEIN from Neisseria meningitidis (serogroup A and B) (383 aa), FASTA scores: opt: 221, E(): 2.1e-06, (27.8% identity in 356 aa overlap); Q9HVX7|PA4438 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (364 aa),FASTA scores: opt: 211, E(): 8.5e-06, (28.9% identity in 353 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TY54	No	conserved hypotheticals							IPR005654,IPR027417	Q7TY54	A0A1R3Y224				Rv2670c		Rv2670c			
NC_002945.3	Mycobrowser_v4	CDS	2944161	2945747	.	+	0	Mb2691	Mb2691		POSSIBLE SECRETED PROTEASE	Mb2691, -, len: 528 aa. Equivalent to Rv2672, len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 528 aa overlap). Possible secreted protease (EC 3.4.-.-), equivalent to O05685|MLC1351.24|ML1339 PUTATIVE SECRETED PROTEASE from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722,E(): 9.4e-140, (74.45% identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE PROTEINASE from Streptomyces lividans (513 aa), FASTA scores: opt: 429,E(): 6.8e-16, (26.2% identity in 538 aa overlap); Q9FCK9|2SC3B6.03c PEPTIDASE from Streptomyces coelicolor (513 aa), FASTA scores: opt: 421, E(): 1.8e-15, (26.45% identity in 541 aa overlap); Q10508|YM23_MYCTU from Mycobacterium tuberculosis (520 aa), FASTA scores: opt: 349, E(): 1.4e-11, (26.6% identity in 523 aa overlap); etc. Equivalent to AAK47061 from Mycobacterium tuberculosis strain CDC1551 (518 aa) but longer 10 aa.	Q7TY52	No	intermediary metabolism and respiration							IPR013595	Q7TY52	A0A1R3Y1V3				Rv2672		Rv2672			
NC_002945.3	Mycobrowser_v4	CDS	1282215	1282856	.	-	0	Mb1185c	Mb1185c		HYPOTHETICAL PROTEIN	Mb1185c, -, len: 213 aa. Equivalent to Rv1154c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 213 aa overlap). Hypothetical unknown protein, start uncertain.	Q7U0I8,A0A1R3XXV6	No	conserved hypotheticals			A0A1R3XXV6				IPR012545	Q7U0I8					Rv1154c		Rv1154c			
NC_002945.3	Mycobrowser_v4	CDS	3001011	3001625	.	-	0	Mb2751c	Mb2751c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2751c, -, len: 204 aa. Equivalent to Rv2732c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Probable conserved transmembrane protein, similar to Q49834 hypothetical protein B2235_C1_155 from Mycobacterium leprae (209 aa),FASTA scores: opt: 932, E(): 0, (70.6% identity in 201 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.	Q7TY06	No	cell wall and cell processes								Q7TY06	A0A1R3Y212				Rv2732c		Rv2732c			
NC_002945.3	Mycobrowser_v4	CDS	2948467	2949162	.	-	0	Mb2695c	Mb2695c		conserved protein	Mb2695c, -, len: 231 aa. Equivalent to Rv2676c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Conserved hypothetical protein, equivalent to Q9CCB2|ML1045 (alias Q50009|U1764Y but longer 66 aa) HYPOTHETICAL PROTEIN from Mycobacterium leprae (231 aa), FASTA scores: opt: 1401,E(): 8.7e-88, (87.45% identity in 231 aa overlap). Also highly similar to O69830|SC1B5.02 HYPOTHETICAL 28.1 KDA PROTEIN from Streptomyces coelicolor (243 aa), FASTA scores: opt: 915, E(): 7.7e-55, (61.25% identity in 222 aa overlap); and similar to others e.g. Q9RUB0|DR1481 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (289 aa), FASTA scores: opt: 327, E(): 6.1e-15, (31.8% identity in 176 aa overlap); Q97WP2|SSO2169 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (223 aa), FASTA scores: opt: 285, E(): 3.4e-12, (31.3% identity in 163 aa overlap); BAB59947|TVG0805714 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (223 aa), FASTA scores: opt: 206, E(): 7.7e-07,(25.0% identity in 176 aa overlap); etc.	Q7TY48	No	conserved hypotheticals							IPR010644,IPR011008	Q7TY48	A0A1R3Y1U9				Rv2676c		Rv2676c			
NC_002945.3	Mycobrowser_v4	CDS	2971839	2972489	.	+	0	Mb2719	Mb2719		possible conserved secreted alanine rich protein	Mb2719, -, len: 216 aa. Equivalent to Rv2700, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Possible secreted ala-rich protein, equivalent to Q4998|ML1025|U1764H POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (216 aa), FASTA scores: opt: 1198, E(): 1.2e-65, (82.4% identity in 216 aa overlap). Also showing some similarity with Q9AK75|2SCD60.08c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (204 aa), FASTA scores: opt: 193,E(): 8.9e-05, (31.25% identity in 192 aa overlap).	Q7TY28	No	cell wall and cell processes							IPR027381	Q7TY28	A0A1R3Y250				Rv2700		Rv2700			
NC_002945.3	Mycobrowser_v4	CDS	2952741	2953373	.	+	0	Mb2699	Mb2699		conserved protein	Mb2699, -, len: 210 aa. Equivalent to Rv2680, len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Conserved hypothetical protein, equivalent to Q50005|ML1041|U1764V HYPOTHETICAL PROTEIN from Mycobacterium leprae (196 aa),FASTA scores: opt: 1136, E(): 9.7e-66, (83.95% identity in 193 aa overlap). Also similar to O69860|SC1C3.18c HYPOTHETICAL 24.7 KDA PROTEIN from Streptomyces coelicolor (238 aa), FASTA scores: opt: 516, E(): 5.7e-26, (45.5% identity in 189 aa overlap); and similar in part to Q9I6V4|PA0178 PROBABLE TWO-COMPONENT SENSOR from Pseudomonas aeruginosa (639 aa), FASTA scores: opt: 120,E(): 3.1, (33.05% identity in 115 aa overlap); and a few other proteins. Equivalent to AAK47069 from Mycobacterium tuberculosis strain CDC1551 (178 aa) but longer 32 aa; and N-terminus highly similar to N-terminus of AAK48352|MT3984 HYPOTHETICAL 4.2 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (38 aa), FASTA scores: opt: 102, E(): 3.6, (62.05% identity in 29 aa overlap).	Q7TY45	No	conserved hypotheticals							IPR021555	Q7TY45	A0A1R3Y229				Rv2680		Rv2680			
NC_002945.3	Mycobrowser_v4	CDS	2953375	2954691	.	+	0	Mb2700	Mb2700		CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN	Mb2700, -, len: 438 aa. Equivalent to Rv2681, len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 438 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q50004|ML1040|U1764U HYPOTHETICAL PROTEIN from Mycobacterium leprae (429 aa),FASTA scores: opt: 2146, E(): 1.1e-119, (77.4% identity in 416 aa overlap). Also highly similar to O69858|SC1C3.16c HYPOTHETICAL 42.5 KDA PROTEIN from Streptomyces coelicolor (394 aa), FASTA scores: opt: 1336, E(): 9e-72, (51.6% identity in 405 aa overlap); and with some similarity to RIBONUCLEASES D e.g. Q983F2|MLL8354 from Rhizobium loti (Mesorhizobium loti) (383 aa), FASTA scores: opt: 379,E(): 3.9e-15, (31.6% identity in 323 aa overlap); Q9A7L8|CC1704 from Caulobacter crescentus (389 aa), FASTA scores: opt: 370, E(): 1.3e-14, (31.45% identity in 318 aa overlap); CAC45770 from Rhizobium meliloti (Sinorhizobium meliloti) (383 aa), FASTA scores: opt: 331, E(): 2.7e-12,(27.75% identity in 357 aa overlap); etc.	Q7TY44	No	conserved hypotheticals							IPR002121,IPR002562,IPR010997,IPR012337	Q7TY44	A0A1R3Y2A8				Rv2681		Rv2681			
NC_002945.3	Mycobrowser_v4	CDS	2956748	2957245	.	+	0	Mb2702	Mb2702		conserved protein	Mb2702, -, len: 165 aa. Equivalent to Rv2683, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 165 aa overlap). Conserved hypothetical protein, equivalent, but shorter 19 aa, to Q49999|ML1037|U1764Q HYPOTHETICAL PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: opt: 750,E(): 1.2e-41, (73.8% identity in 164 aa overlap). Shows some similarity with other HYPOTHETICAL PROTEINS e.g. Q988S9|MLL6611 from Rhizobium loti (Mesorhizobium loti) (232 aa), FASTA scores: opt: 128, E(): 0.25, (25.5% identity in 149 aa overlap); Q9YFL5|APE0233 from Aeropyrum pernix (340 aa), FASTA scores: opt: 123, E(): 0.73, (29.1% identity in 141 aa overlap); BAB60477|TVG1377730 from Thermoplasma volcanium (174 aa), FASTA scores: opt: 118,E(): 0.86, (28.8% identity in 59 aa overlap); etc.	Q7TY43	No	conserved hypotheticals							IPR000644,IPR013785	Q7TY43	A0A1R3Y1V9				Rv2683		Rv2683			
NC_002945.3	Mycobrowser_v4	CDS	2546033	2546485	.	+	0	Mb2319	Mb2319		unknown protein	Mb2319, -, len: 150 aa. Equivalent to Rv2297, len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 150 aa overlap). Unknown protein; contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide	X2BJX4,P64980	No	conserved hypotheticals			P64980					X2BJX4					Rv2297		Rv2297			
NC_002945.3	Mycobrowser_v4	CDS	2959916	2960674	.	-	0	Mb2705c	Mb2705c		antibiotic-transport integral membrane leucine and alanine and valine rich protein abc transporter	Mb2705c, -, len: 252 aa. Equivalent to Rv2686c,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable antibiotic-transport integral membrane leu-, ala-,val-rich protein ABC transporter (see citation below). The region from aa ~115 to 160 is highly similar to N-terminus of Q49998|U1764P HYPOTHETICAL PROTEIN from Mycobacterium leprae (53 aa), FASTA scores: opt: 151, E(): 0.011,(58.15% identity in 43 aa overlap). Shows some similarity with membrane proteins e.g. AAK75541|SP1447 MEMBRANE PROTEIN from Streptococcus pneumoniae (298 aa), FASTA scores: opt: 139, E(): 0.21, (29.65% identity in 135 aa overlap); Q9K4C9|2SC6G5.26c PUTATIVE ABC TRANSPORTER INTEGRAL MEMBRANE SUBUNIT from Streptomyces coelicolor (249 aa), FASTA scores: opt: 138, E(): 0.21, (26.9% identity in 253 aa overlap); Q53627|MTRB MEMBRANE PROTEIN INVOLVED IN MITHRAMYCIN RESISTANCE from Streptomyces argillaceus (233 aa), FASTA scores: opt: 136, E(): 0.27,(26.7% identity in 191 aa overlap); etc.	Q7TY41	No	cell wall and cell processes								Q7TY41	A0A1R3Y1W1				Rv2686c		Rv2686c			
NC_002945.3	Mycobrowser_v4	CDS	2960671	2961384	.	-	0	Mb2706c	Mb2706c		antibiotic-transport integral membrane leucine and valine rich protein abc transporter	Mb2706c, -, len: 237 aa. Equivalent to Rv2687c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Probable antibiotic-transport integral membrane leu-, val-rich protein ABC transporter (see citation below), showing some similarity with two other hypothetical proteins,BAB59668|TVG0517148 from Thermoplasma volcanium (241 aa),FASTA scores: opt: 136, E(): 0.32, (23.1% identity in 208 aa overlap); and Q97U55|SSO3168 from Sulfolobus solfataricus (249 aa), FASTA scores: opt: 136, E(): 0.33,(25.15% identity in 195 aa overlap). Has some hydrophobic stretches and contains bacterial regulatory proteins, araC family signature (PS00041).	Q7TY40	No	cell wall and cell processes							IPR013525	Q7TY40	A0A1R3Y1W6				Rv2687c		Rv2687c			
NC_002945.3	Mycobrowser_v4	CDS	2987676	2988173	.	-	0	Mb2738c	Mb2738c		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb2738c, -, len: 165 aa. Equivalent to Rv2719c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 165 aa overlap). Possible conserved membrane protein, equivalent to Q49846|ML1004|B2235_C3_243 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (164 aa), FASTA scores: opt: 486, E(): 4e-21,(55.2% identity in 163 aa overlap).	Q7TY16	No	cell wall and cell processes							IPR018392	Q7TY16	A0A1R3Y2T8				Rv2719c		Rv2719c			
NC_002945.3	Mycobrowser_v4	CDS	2961381	2962286	.	-	0	Mb2707c	Mb2707c		antibiotic-transport atp-binding protein abc transporter	Mb2707c, -, len: 301 aa. Equivalent to Rv2688c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 301 aa overlap). Probable antibiotic-transport ATP-binding protein ABC transporter (see citation below), highly similar to AAK47077|MT2762 ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551 (317 aa), FASTA scores: opt: 1714, E(): 5.1e-93, (95.6% identity in 274 aa overlap). Also highly similar to other ATP-BINDING PROTEINS ABC TRANSPORTER e.g. Q9K639|BH3893 from Bacillus halodurans (282 aa), FASTA scores: opt: 644, E(): 1.4e-30, (38.% identity in 285 aa overlap); O58550|PH0820 from Pyrococcus horikoshii (312 aa), FASTA scores: opt: 574, E(): 1.8e-26,(39.1% identity in 307 aa overlap); Q9WYM0|TM0389 from Thermotoga maritima (301 aa), FASTA scores: opt: 536, E(): 2.9e-24, (36.1% identity in 291 aa overlap); etc. Has ATP/GTP-binding site motif A (P-loop) at N-terminus (PS00017). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TY39	No	cell wall and cell processes							IPR003439,IPR003593,IPR017871,IPR027417	Q7TY39	A0A1R3Y3X6				Rv2688c		Rv2688c			
NC_002945.3	Mycobrowser_v4	CDS	2962481	2963698	.	-	0	Mb2708c	Mb2708c		conserved alanine and valine and glycine rich protein	Mb2708c, -, len: 405 aa. Equivalent to Rv2689c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Conserved hypothetical ala-, val-, gly-rich protein, similar to O54099|SC10A5.06 HYPOTHETICAL 49.5 KDA PROTEIN from Streptomyces coelicolor (458 aa), FASTA scores: opt: 455,E(): 2.7e-20, (38.35% identity in 417 aa overlap); and shows weak similarity in part with several methyltransferases (EC 2.1.1.-) e.g. Q9X0H9|TM1094 PUTATIVE RNA METHYLTRANSFERASE from Thermotoga maritima (439 aa), FASTA scores: opt: 306, E(): 3e-11, (25.9% identity in 436 aa overlap); AK79403|CAC1435 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES from Clostridium acetobutylicum (456 aa), FASTA scores: opt: 294, E(): 1.6e-10, (23.4% identity in 449 aa overlap); Q9A8M7|CC1326 RNA METHYLTRANSFERASE from Caulobacter crescentus (415 aa), FASTA scores: opt: 247, E(): 1.1e-07,(28.4% identity in 433 aa overlap); etc. Equivalent to AAK47078 from Mycobacterium tuberculosis strain CDC1551 (434 aa) but shorter 29 aa. Other less probable starts possible.	Q7TY38	No	conserved hypotheticals							IPR002792,IPR010280,IPR012340	Q7TY38	A0A1R3Y2Q7				Rv2689c		Rv2689c			
NC_002945.3	Mycobrowser_v4	CDS	3058130	3058711	.	-	0	Mb2815c	Mb2815c		POSSIBLE RESOLVASE	Mb2815c, -, len: 193 aa. Equivalent to Rv2792c,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 193 aa overlap). Possible IS1602 resolvase, highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c POSSIBLE RESOLVASE (202 aa), FASTA scores: opt: 1040, E(): 1.9e-62,(85.05% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site and possible helix-turn-helix motif at aa 1-2 (Score 1687, +4.93 SD).	Q7TXV2	No	insertion seqs and phages							IPR006118,IPR006119	Q7TXV2	A0A1R3Y260				Rv2792c		Rv2792c			
NC_002945.3	Mycobrowser_v4	CDS	2963854	2965845	.	-	0	Mb2709c	Mb2709c		PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND VALINE AND LEUCINE RICH PROTEIN	Mb2709c, -, len: 663 aa. Equivalent to Rv2690c,len: 657 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 657 aa overlap). Probable conserved integral membrane ala-, val-, leu-rich protein, highly similar to others e.g. O54098|SC10A5.05 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (691 aa), FASTA scores: opt: 2007, E(): 1.6e-116, (62.35% identity in 669 aa overlap); O69917|SC3C8.04c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (644 aa), FASTA scores: opt: 923, E(): 1.7e-49, (35.3% identity in 669 aa overlap); AAK78253|CAC0272 AMINO ACID TRANSPORTER from Clostridium acetobutylicum (620 aa), FASTA scores: opt: 674, E(): 4.1e-34, (36.55% identity in 640 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657 aa).	Q7TY37	No	cell wall and cell processes							IPR002293	Q7TY37	A0A1R3Y240				Rv2690c		Rv2690c			
NC_002945.3	Mycobrowser_v4	CDS	2980906	2981964	.	-	0	Mb2731c	Mb2731c		HYPOTHETICAL PROTEIN	Mb2731c, -, len: 352 aa. Equivalent to Rv2712c,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Hypothetical unknown ala-, leu-rich protein.	Q7TY19	No	conserved hypotheticals							IPR025447	Q7TY19	A0A1R3Y1Z1				Rv2712c		Rv2712c			
NC_002945.3	Mycobrowser_v4	CDS	2967333	2968004	.	-	0	Mb2712c	Mb2712c		PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND LEUCINE RICH PROTEIN	Mb2712c, -, len: 223 aa. Equivalent to Rv2693c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Probable conserved integral membrane ala-, leu-rich protein, showing some similarity to O54140|SC2E9.15 HYPOTHETICAL 29.6 KDA PROTEIN from Streptomyces coelicolor (272 aa), FASTA scores: opt: 212, E(): 4.3e-06, (23.5% identity in 247 aa overlap).	Q7TY34	No	cell wall and cell processes							IPR016566	Q7TY34	A0A1R3Y1X1				Rv2693c		Rv2693c			
NC_002945.3	Mycobrowser_v4	CDS	2968035	2968403	.	-	0	Mb2713c	Mb2713c		conserved protein	Mb2713c, -, len: 122 aa. Equivalent to Rv2694c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 122 aa overlap). Conserved hypothetical protein, highly similar in part to SC2E9.14 HYPOTHETICAL 16.9 KDA PROTEIN from Streptomyces coelicolor (154 aa),FASTA scores: opt: 299, E(): 1.9e-13, (41.05% identity in 117 aa overlap. Equivalent to AAK47083 from Mycobacterium tuberculosis strain CDC1551 (157 aa) but shorter 35 aa.	Q7TY33	No	conserved hypotheticals							IPR012340,IPR016499	Q7TY33	A0A1R3Y1X3				Rv2694c		Rv2694c			
NC_002945.3	Mycobrowser_v4	CDS	2968552	2969259	.	+	0	Mb2714	Mb2714		CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN	Mb2714, -, len: 235 aa. Equivalent to Rv2695, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 235 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q49994|ML1030|U1764L HYPOTHETICAL PROTEIN from Mycobacterium leprae (232 aa), FASTA scores: opt: 1166,E(): 6.3e-63, (76.95% identity in 230 aa overlap). Also shows some similarity with other hypothetical proteins e.g. Q986S2|MLR7232 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (277 aa), FASTA scores: opt: 150, E(): 0.059, (33.55% identity in 173 aa overlap); CAC47772|SMC03810 HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (269 aa), FASTA scores: opt: 143, E(): 0.15, (28.05% identity in 228 aa overlap); Q9A5N6|CC2411 3-OXOADIPATE ENOL-LACTONE HYDROLASE/4-CARBOXYMUCONOLACTONE DECARBOXYLASE from Caulobacter crescentus (393 aa), FASTA scores: opt: 138,E(): 0.41, (26.45% identity in 238 aa overlap); etc.	Q7TY32	No	conserved hypotheticals								Q7TY32	A0A1R3Y1Y2				Rv2695		Rv2695			
NC_002945.3	Mycobrowser_v4	CDS	2969465	2970244	.	-	0	Mb2715c	Mb2715c		conserved alanine and glycine and valine rich protein	Mb2715c, -, len: 259 aa. Equivalent to Rv2696c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 259 aa overlap). Conserved hypothetical ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K HYPOTHETICAL PROTEIN from Mycobacterium leprae (273 aa), FASTA scores: opt: 1174,E(): 2.1e-63, (70.6% identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06, (28.25% identity in 255 aa overlap); and showing weak similarity with other proteins.	Q7TY31	No	conserved hypotheticals							IPR022183	Q7TY31	A0A1R3Y1X2				Rv2696c		Rv2696c			
NC_002945.3	Mycobrowser_v4	CDS	3008442	3008648	.	-	0	Mb2758c	Mb2758c		CONSERVED HYPOTHETICAL PROTEIN	Mb2758c, -, len: 68 aa. Equivalent to Rv2738c, len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Conserved hypothetical protein, equivalent to Q9CCC1|ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 397,E(): 3.7e-22, (83.6% identity in 67 aa overlap). Also highly similar to O50484|SC4H8.05 HYPOTHETICAL 7.5 KDA PROTEIN from Streptomyces coelicolor (64 aa), FASTA scores: opt: 185, E(): 5.9e-07, (39.7% identity in 63 aa overlap). Second part of the protein is highly similar to C-terminus of upstream ORF O33285|Rv2742c|MTV002.07c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 200, E(): 1.7e-07, (78.4% identity in 37 aa overlap).	Q7TY02	No	conserved hypotheticals							IPR021408	Q7TY02	A0A1R3Y2V4				Rv2738c		Rv2738c			
NC_002945.3	Mycobrowser_v4	CDS	2976094	2976522	.	+	0	Mb2723	Mb2723		conserved protein	Mb2723, -, len: 142 aa. Equivalent to Rv2704, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, highly similar (but shorter 25 aa) to Q9RYB7|DR0033 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (157 aa), FASTA scores: opt: 381,E(): 1.5e-17, (54.85% identity in 124 aa overlap); and highly similar to various proteins e.g. CAC47758|SMC03796 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (126 aa), FASTA scores: opt: 302,E(): 1.4e-12, (46.6% identity in 126 aa overlap); Q98E55|MLL4402 from Rhizobium loti (Mesorhizobium loti) (130 aa), FASTA scores: opt: 252, E(): 2.1e-09, (40.15% identity in 127 aa overlap); Q9K3V5|SCD10.21 PUTATIVE ACETYLTRANSFERASE from Streptomyces coelicolor (291 aa),FASTA scores: opt: 247, E(): 8.7e-09, (41.3% identity in 138 aa overlap) (homology only in N-terminal region); etc.	Q7TY26	No	conserved hypotheticals							IPR006175,IPR013813	Q7TY26	A0A1R3Y1Y3				Rv2704		Rv2704			
NC_002945.3	Mycobrowser_v4	CDS	2976450	2976839	.	-	0	Mb2724c	Mb2724c		CONSERVED HYPOTHETICAL PROTEIN	Mb2724c, -, len: 129 aa. Equivalent to Rv2705c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to others e.g. Q9RXR5|DR0242 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (112 aa), FASTA scores: opt: 259, E(): 9.4e-10, (40.5% identity in 116 aa overlap); CAC45122|SMC02246 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (115 aa),FASTA scores: opt: 208, E(): 1.6e-06, (38.3% identity in 107 aa overlap); Q98B88|MLL5682 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (116 aa), FASTA scores: opt: 173, E(): 0.00026, (34.95% identity in 103 aa overlap); etc.	Q7TY25	No	conserved hypotheticals							IPR009297	Q7TY25	A0A1R3Y1Z2				Rv2705c		Rv2705c			
NC_002945.3	Mycobrowser_v4	CDS	2977209	2978183	.	+	0	Mb2726	Mb2726		PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN	Mb2726, -, len: 324 aa. Equivalent to Rv2707, len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Probable conserved transmembrane ala-, leu-rich protein, equivalent to Q49985|ML1017|U1764D POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (330 aa), FASTA scores: opt: 1617, E(): 2.5e-91, (75.4% identity in 325 aa overlap). Also similar to other membrane proteins e.g. Q9ADF6|SCBAC1A6.31 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (344 aa), FASTA scores: opt: 593,E(): 5.9e-29, (36.2% identity in 268 aa overlap); Q99SZ8|SA1699 HYPOTHETICAL PROTEIN (similar to transporter) from Staphylococcus aureus subsp. aureus N315 (405 aa), FASTA scores: opt: 318, E(): 3.7e-12, (27.9% identity in 265 aa overlap); O34437|YFKH HYPOTHETICAL PROTEIN (similar to transporter) from Bacillus subtilis (275 aa), FASTA scores: opt: 309, E(): 9.7e-12, (29.3% identity in 263 aa overlap); etc.	Q7TY23	No	conserved hypotheticals							IPR017039	Q7TY23	A0A1R3Y1Y8				Rv2707		Rv2707			
NC_002945.3	Mycobrowser_v4	CDS	2978184	2978432	.	-	0	Mb2727c	Mb2727c		CONSERVED HYPOTHETICAL PROTEIN	Mb2727c, -, len: 82 aa. Equivalent to Rv2708c, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 82 aa overlap). Conserved hypothetical protein, equivalent (but shorter 25 aa) to Q49984|ML1016|U1764C HYPOTHETICAL PROTEIN from Mycobacterium leprae (107 aa), FASTA scores: opt: 492,E(): 7.3e-27, (87.8% identity in 82 aa overlap). Also highly similar to Q9L1U7|SCE59.06c HYPOTHETICAL 10.4 KDA PROTEIN from Streptomyces coelicolor (97 aa), FASTA scores: opt: 200, E(): 4.4e-07, (51.6% identity in 62 aa overlap).	Q7TY22	No	conserved hypotheticals							IPR021400	Q7TY22	A0A1R3Y3Y9				Rv2708c		Rv2708c			
NC_002945.3	Mycobrowser_v4	CDS	2983701	2984675	.	+	0	Mb2733	Mb2733		conserved alanine and leucine rich protein	Mb2733, -, len: 324 aa. Equivalent to Rv2714, len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 324 aa overlap). Conserved hypothetical ala-, leu-rich protein, equivalent to Q49847|ML1009|B2235_F1_6 HYPOTHETICAL PROTEIN from Mycobacterium leprae (326 aa), FASTA scores: opt: 1881,E(): 5.8e-107, (89.7% identity in 320 aa overlap); and similar to Q49797|MLCB2533.03c|B2126_F1_36 HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa), FASTA scores: opt: 376, E(): 1.2e-15, (30.1% identity in 279 aa overlap); and Q9CC38|ML1306 HYPOTHETICAL PROTEIN from Mycobacterium leprae (274 aa), FASTA scores: opt: 367,E(): 3.6e-15, (29.8% identity in 275 aa overlap). Also highly similar to Q9S2K6|SC7H2.11c HYPOTHETICAL 34.2 KDA PROTEIN from Streptomyces coelicolor (312 aa), FASTA scores: opt: 770, E(): 1.4e-39, (40.9% identity in 286 aa overlap); and similar to Q9ADA5|SCI52.04 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 386, E(): 3e-16, (29.05% identity in 296 aa overlap). Also similar to O33260|Rv2125|MTCY261.21 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (292 aa), FASTA scores: opt: 387, E(): 2.3e-16, (29.45% identity in 292 aa overlap).	Q7TY18	No	conserved hypotheticals							IPR008492,IPR013028,IPR019151	Q7TY18	A0A1R3Y1Z3				Rv2714		Rv2714			
NC_002945.3	Mycobrowser_v4	CDS	3064317	3064949	.	+	0	Mb2822	Mb2822		PROBABLE MEMBRANE PROTEIN	Mb2822, -, len: 210 aa. Equivalent to Rv2799, len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 210 aa overlap). Probable membrane protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp insertion (*-ggt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa).	Q7TXU6	No	cell wall and cell processes							IPR024520	Q7TXU6	A0A1R3Y273				Rv2799		Rv2799			
NC_002945.3	Mycobrowser_v4	CDS	3072293	3072694	.	-	0	Mb2833c	Mb2833c		PROBABLE TRANSPOSASE	Mb2833c, -, len: 133 aa. Equivalent to Rv2810c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable transposase for IS1555, similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA TRANSPOSASE from Arthrobacter sp. TM1 (435 aa), FASTA scores: opt: 294,E(): 1.8e-13, (55.1% identity in 98 aa overlap); Q50440|TNPA INSERTION ELEMENT TNPR AND TNPA GENE from Mycobacterium smegmatis (413 aa), FASTA scores: opt: 274,E(): 4.7e-12, (56.25% identity in 96 aa overlap); etc.		No	insertion seqs and phages													Rv2810c		Rv2810c			
NC_002945.3	Mycobrowser_v4	CDS	2984734	2985759	.	+	0	Mb2734	Mb2734		POSSIBLE HYDROLASE	Mb2734, -, len: 341 aa. Equivalent to Rv2715, len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 341 aa overlap). Possible hydrolase (EC 3.-.-.-), showing some similarity with other hydrolases e.g. Q9I5B0|PA0829 PROBABLE HYDROLASE from Pseudomonas aeruginosa (313 aa), FASTA scores: opt: 336,E(): 9.9e-14, (28.05% identity in 289 aa overlap); BAB55888 HYDROLASE (FRAGMENT) from Terrabacter sp. DBF63 (319 aa), FASTA scores: opt: 326, E(): 4.2e-13, (27.95% identity in 290 aa overlap); O52866|CEH|EH SOLUBLE EPOXIDE HYDROLASE from Corynebacterium SP (285 aa), FASTA scores: opt: 325, E(): 4.4e-13, (29.95% identity in 284 aa overlap); etc. Also shows some similarity to P96811|EPHF|Rv0134|MTCI5.08 HYPOTHETICAL 33.8 KDA PROTEINfrom Mycobacterium tuberculosis (300 aa), FASTA scores: E(): 1.8e-10, (27.7% identity in 271 aa overlap). Contains lipases, serine active site motif (PS00120).	X2BLN7,P0A573	No	intermediary metabolism and respiration								X2BLN7,P0A573	P0A573				Rv2715		Rv2715			
NC_002945.3	Mycobrowser_v4	CDS	2985808	2986494	.	+	0	Mb2735	Mb2735		conserved protein	Mb2735, -, len: 228 aa. Equivalent to Rv2716, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Conserved hypothetical protein, similar to other proteins e.g. Q9RKR0|SCC75A.14 HYPOTHETICAL 23.3 KDA PROTEIN from Streptomyces coelicolor (214 aa), FASTA scores: opt: 447,E(): 4e-22, (44.1% identity in 220 aa overlap); Q9HHG6|PHZF|VNG6408G PHENAZINE BIOSYNTHETIC PROTEIN from Halobacterium sp. strain NRC-1 (299 aa), FASTA scores: opt: 201, E(): 6.1e-06, (30.4% identity in 148 aa overlap) (similarity only at N-terminus); P73125|SLR1019 HYPOTHETICAL 34.1 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (314 aa), FASTA scores: opt: 196, E(): 1.4e-05, (28.5% identity in 298 aa overlap); etc.	X2BLC6,P0A5G8	No	conserved hypotheticals								X2BLC6,P0A5G8	P0A5G8				Rv2716		Rv2716			
NC_002945.3	Mycobrowser_v4	CDS	3012994	3013806	.	-	0	Mb2764c	Mb2764c		possible conserved transmembrane alanine rich protein	Mb2764c, -, len: 270 aa. Equivalent to Rv2743c,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Possible conserved membrane ala-rich protein, equivalent to Q49833|MLCB33.04c|B2235_C1_148 UNKNOWN PROTEIN from Mycobacterium leprae (123 aa), FASTA scores: opt: 639,E(): 3.3e-31, (74.8% identity in 123 aa overlap).	Q7TXZ6	No	cell wall and cell processes								Q7TXZ6	A0A1R3Y231				Rv2743c		Rv2743c			
NC_002945.3	Mycobrowser_v4	CDS	2986503	2986997	.	-	0	Mb2736c	Mb2736c		conserved protein	Mb2736c, -, len: 164 aa. Equivalent to Rv2717c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Conserved hypothetical protein, equivalent to Q9CCB8|ML1006 (alias Q49838 but shortened N-terminus) HYPOTHETICAL PROTEIN from Mycobacterium leprae (161 aa), FASTA scores: opt: 797,E(): 2.3e-46, (73.8% identity in 164 aa overlap). Also highly similar to other eukaryotic proteins e.g. O64527|YUP8H12R.14 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (166 aa), FASTA scores: opt: 393, E(): 2.3e-19, (42.4% identity in 158 aa overlap); Q9Y325 CGI-36 PROTEIN from Homo sapiens (Human) (165 aa),FASTA scores: opt: 294, E(): 9.5e-13, (33.95% identity in 159 aa overlap); etc.	X2BLN9,Q7TY17	No	conserved hypotheticals								X2BLN9,Q7TY17	Q7TY17				Rv2717c		Rv2717c			
NC_002945.3	Mycobrowser_v4	CDS	2989156	2991255	.	-	0	Mb2740c	Mb2740c		POSSIBLE CONSERVED TRANSMEMBRANE ALANINE AND GLYCINE RICH PROTEIN	Mb2740c, -, len: 699 aa. Equivalent to Rv2721c,len: 699 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 699 aa overlap). Possible conserved transmembrane ala-, gly-rich protein, equivalent to Q49837|ML1002|U2235I POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (687 aa), FASTA scores: opt: 2703, E(): 6.6e-135, (60.3% identity in 713 aa overlap). Shows some similaity to Q01377|CSP1 PS1 PROTEIN PRECURSOR (SECRETED PROTEIN) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa), FASTA scores: opt: 276,E(): 3.8e-07, (29.4% identity in 272 aa overlap); and Q9KIJ0 Rv2721c-LIKE PROTEIN from Mycobacterium paratuberculosis (246 aa), FASTA scores: opt: 178, E(): 0.025, (37.5% identity in 120 aa overlap).	Q7TY14	No	cell wall and cell processes							IPR013207	Q7TY14	A0A1R3Y2F1				Rv2721c		Rv2721c			
NC_002945.3	Mycobrowser_v4	CDS	2991271	2991519	.	+	0	Mb2741	Mb2741		CONSERVED HYPOTHETICAL PROTEIN	Mb2741, -, len: 82 aa. Equivalent to Rv2722, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 82 aa overlap). Conserved hypothetical protein, similar to Q9CCB9|ML1001 HYPOTHETICAL PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 154,E(): 0.00053, (37.5% identity in 88 aa overlap). Equivalent to AAK47111 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but shorter by 12 aa.	Q7TY13	No	conserved hypotheticals								Q7TY13	A0A1R3Y1Z8				Rv2722		Rv2722			
NC_002945.3	Mycobrowser_v4	CDS	3001622	3003160	.	-	0	Mb2752c	Mb2752c		CONSERVED HYPOTHETICAL ALANINE, ARGININE-RICH PROTEIN	Mb2752c, -, len: 512 aa. Equivalent to Rv2733c,len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Conserved hypothetical ala-, arg-rich protein. Similar to other hypothetical proteins from a range of organisms e.g. Y195_MYCLE|Q49842 hypothetical 56.0 kd protein b2235_c2_195 from Mycobacterium leprae (516 aa), FASTA scores: opt: 2689, E(): 0, (80.4% identity in 509 aa overlap).	X2BM44,P67086	No	conserved hypotheticals								X2BM44,P67086	P67086				Rv2733c		Rv2733c			
NC_002945.3	Mycobrowser_v4	CDS	2991545	2992738	.	+	0	Mb2742	Mb2742		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2742, -, len: 397 aa. Equivalent to Rv2723, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Probable conserved integral membrane protein, highly similar to others e.g. Q9Z503|SCC54.23c PUTATIVE INTEGRAL MEMBRANE EXPORT PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 883, E(): 2.4e-48, (46.4% identity in 332 aa overlap); Q9RD18|SCM1.25c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 865,E(): 3.1e-47, (47.55% identity in 324 aa overlap); P96554|Y319_MYXXA INTEGRAL MEMBRANE PROTEIN (PROBABLE) from Myxococcus xanthus (319 aa), FASTA scores: opt: 626,E(): 3.4e-32, (34.65% identity in 323 aa overlap); P42601|YGJT_ECOLI|B3088 from Escherichia coli strain K12 INTEGRAL MEMBRANE PROTEIN (PROBABLE) (321 aa), FASTA scores: opt: 541, E(): 7.7e-27, (35.1% identity in 279 aa overlap); etc.	X2BM35,P0A615	No	cell wall and cell processes								X2BM35,P0A615	P0A615				Rv2723		Rv2723			
NC_002945.3	Mycobrowser_v4	CDS	3084815	3085525	.	-	0	Mb2845c	Mb2845c		CONSERVED HYPOTHETICAL PROTEIN	Mb2845c, -, len: 236 aa. Equivalent to Rv2821c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins e.g. Q9X2C9|TM1809 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (247 aa), FASTA scores: opt: 318,E(): 8.2e-15, (39.45% identity in 213 aa overlap); O27152|MTH1080 CONSERVED HYPOTHETICAL PROTEIN from Methanothermobacter thermautotrophicus (245 aa), FASTA scores: opt: 294, E(): 3.9e-13, (34.8% identity in 224 aa overlap); BAB59251|TVG0114661 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (229 aa), FASTA scores: opt: 252,E(): 3.3e-10, (33.8% identity in 225 aa overlap); etc.	Q7TXS6	No	conserved hypotheticals							IPR005537,IPR013412	Q7TXS6	A0A1R3Y2C4				Rv2821c		Rv2821c			
NC_002945.3	Mycobrowser_v4	CDS	2997402	2998097	.	-	0	Mb2747c	Mb2747c		conserved alanine rich protein	Mb2747c, -, len: 231 aa. Equivalent to Rv2728c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q49835|ML0994|B2235_C1_162 HYPOTHETICAL PROTEIN from Mycobacterium leprae (232 aa), FASTA scores: opt: 1037,E(): 1.2e-54, (68.55% identity in 232 aa overlap). Also similar to O69964|SC4H2.09 from Streptomyces coelicolor (237 aa), FASTA scores: opt: 300, E(): 7.7e-11, (32.8% identity in 241 aa overlap); and some similarity with other proteins e.g. Q14234|ELN ELASTIN from Homo sapiens (Human) (757 aa), FASTA scores: opt: 161, E(): 0.03,(30.6% identity in 242 aa overlap); P55488|Y4IE HYPOTHETICAL 15.4 KDA PROTEIN from Rhizobium sp. strain NGR234 (135 aa), FASTA scores: opt: 147, E(): 0.061,(34.95% identity in 123 aa overlap). Shows also some similarity with P71657|Rv1387|MTCY21B4.04 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (539 aa), FASTA scores: opt: 159, E(): 0.035, (34.8% identity in 135 aa overlap).	Q7TY10	No	conserved hypotheticals								Q7TY10	A0A1R3Y408				Rv2728c		Rv2728c			
NC_002945.3	Mycobrowser_v4	CDS	2998206	2999111	.	-	0	Mb2748c	Mb2748c		probable conserved integral membrane alanine valine and leucine rich protein	Mb2748c, -, len: 301 aa. Equivalent to Rv2729c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 301 aa overlap). Probable conserved integral membrane ala-, val-, leu-rich protein, similar to P42459|YLEU_CORGL HYPOTHETICAL 29.6 KDA PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum)(270 aa), FASTA scores: opt: 365, E(): 4.7e-15, (30.75% identity in 221 aa overlap); and to other integral membrane proteins (principally from Streptomyces sp.) e.g. Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa),FASTA scores: opt: 365, E(): 5.2e-15, (32.0% identity in 278 aa overlap); Q9S267|SCI30A.06 from Streptomyces coelicolor (297 aa), FASTA scores: opt: 356, E(): 1.8e-14,(31.5% identity in 289 aa overlap); AAK81278|CAC3346 from Clostridium acetobutylicum (472 aa), FASTA scores: opt: 154, E(): 0.038, (24.1% identity in 224 aa overlap); etc.	Q7TY09	No	cell wall and cell processes								Q7TY09	A0A1R3Y2U4				Rv2729c		Rv2729c			
NC_002945.3	Mycobrowser_v4	CDS	2999662	3001014	.	+	0	Mb2750	Mb2750		conserved alanine and arginine rich protein	Mb2750, -, len: 450 aa. Equivalent to Rv2731, len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 450 aa overlap). Conserved hypothetical ala-, arg-rich protein, highly similar in part to Q49849|B2235_F2_77 HYPOTHETICAL PROTEIN from Mycobacterium leprae (266 aa), FASTA scores: opt: 368,E(): 1e-10, (73.5% identity in 83 aa overlap); and Q9KXN9|SC9C5.35 HYPOTHETICAL 6.5 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (58 aa), FASTA scores: opt: 214, E(): 0.00065, (51.7% identity in 58 aa overlap). Also similar to Q9L296|SCL2.01 HYPOTHETICAL 37.4 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (328 aa), FASTA scores: opt: 843, E(): 3.7e-33, (45.95% identity in 296 aa overlap) (but N-terminus shorter); and shows some similarity with other proteins e.g. Q26938 KINETOPLAST-ASSOCIATED PROTEIN (KAP) from Trypanosoma cruzi (1052 aa), FASTA scores: opt: 223, E(): 0.0022,(30.3% identity in 297 aa overlap). Start site chosen by RBS and to avoid overlap, although there are several other possible start sites further upstream.	Q7TY07	No	conserved hypotheticals							IPR007139	Q7TY07	A0A1R3Y2G1				Rv2731		Rv2731			
NC_002945.3	Mycobrowser_v4	CDS	3019079	3019393	.	+	0	Mb2770	Mb2770		conserved protein	Mb2770, -, len: 104 aa. Equivalent to Rv2749, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Conserved hypothetical protein, showing some similarity with Q9I1R9|PA2198 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (114 aa), FASTA scores: opt: 157, E(): 0.00081,(35.0% identity in 100 aa overlap); and O86332|Rv0793|MTV042.03 HYPOTHETICAL 11.2 KDA PROTEIN from Mycobacterium tuberculosis (101 aa), FASTA scores: opt: 143, E(): 0.0062, (26.9% identity in 93 aa overlap).	Q7TXZ0	No	conserved hypotheticals							IPR007138,IPR011008	Q7TXZ0	A0A1R3Y2I1				Rv2749		Rv2749			
NC_002945.3	Mycobrowser_v4	CDS	3003457	3004311	.	+	0	Mb2753	Mb2753		CONSERVED HYPOTHETICAL PROTEIN	Mb2753, -, len: 284 aa. Equivalent to Rv2734, len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Conserved hypothetical protein, highly similar to various proteins e.g. Q984J2|MLR7981 ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 877, E(): 9e-50, (52.45% identity in 246 aa overlap) (N-terminus longer); Q98DH1|MLL4707 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (249 aa),FASTA scores: opt: 829, E(): 1.1e-46, (50.4% identity in 244 aa overlap); AAK65865|SMA2239 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (259 aa), FASTA scores: opt: 796, E(): 1.5e-44, (50.0% identity in 252 aa overlap); etc.	Q7TY05	No	conserved hypotheticals							IPR011101	Q7TY05	A0A1R3Y213				Rv2734		Rv2734			
NC_002945.3	Mycobrowser_v4	CDS	3004196	3005188	.	-	0	Mb2754c	Mb2754c		CONSERVED HYPOTHETICAL PROTEIN	Mb2754c, -, len: 330 aa. Equivalent to Rv2735c,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Conserved hypothetical protein, showing some similarity with Q98DH2|MLR4706 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (302 aa), FASTA scores: opt: 140,E(): 0.062, (27.0% identity in 200 aa overlap); and Q9PHA1|XF0043 HYPOTHETICAL PROTEIN from Xylella fastidiosa (293 aa), FASTA scores: opt: 120, E(): 1.2, (30.75% identity in 117 aa overlap).	Q7TY04	No	conserved hypotheticals								Q7TY04	A0A1R3Y227				Rv2735c		Rv2735c			
NC_002945.3	Mycobrowser_v4	CDS	3008659	3009825	.	-	0	Mb2759c	Mb2759c		POSSIBLE ALANINE RICH TRANSFERASE	Mb2759c, -, len: 388 aa. Equivalent to Rv2739c,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Possible ala-rich transferase (EC 2.-.-.-), equivalent to Q49841|ML0985|MLCB33.02c|U2235C POSSIBLE GLYCOSYLTRANSFERASE from Mycobacterium leprae (392 aa),FASTA scores: opt: 2112, E(): 5.1e-114, (80.95% identity in 388 aa overlap). Shows some similarity with other transferases e.g. Q9S1V2|SCJ4.21 PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (407 aa), FASTA scores: opt: 290, E(): 2e-09, (27.75% identity in 382 aa overlap); Q9RYI3|DRA0329 PUTATIVE GLYCOSYLTRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 267,E(): 4.3e-08, (29.05% identity in 396 aa overlap); P96560|GTFC GLYCOSYLTRANSFERASE from Amycolatopsis orientalis (409 aa), FASTA scores: opt: 253, E(): 2.7e-07,(27.75% identity in 418 aa overlap); etc. Equivalent to AAK47130 from Mycobacterium tuberculosis strain CDC1551 (420 aa) but shorter 32 aa.	Q7TY01	No	intermediary metabolism and respiration							IPR002213,IPR007235	Q7TY01	A0A1R3Y285				Rv2739c		Rv2739c			
NC_002945.3	Mycobrowser_v4	CDS	3152061	3152948	.	-	0	Mb2910c	Mb2910c		PROBABLE RESOLVASE	Mb2910c, -, len: 295 aa. Equivalent to Rv2886c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Probable resolvase for IS1539. Contains PS00213 Lipocalin signature.	X2BLT9,P65046	No	insertion seqs and phages								X2BLT9,P65046	P65046				Rv2886c		Rv2886c			
NC_002945.3	Mycobrowser_v4	CDS	3012066	3012314	.	-	0	Mb2762c	Mb2762c		CONSERVED HYPOTHETICAL ARGININE RICH PROTEIN [SECOND PART]	Mb2762c, -, len: 82 aa. Equivalent to 3' end of Rv2742c, len: 277 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Conserved hypothetical arg-rich protein. Extreme N-terminus is highly similar to the N-teminus of Q9CCC1ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 183, E(): 0.00052,(71.05% identity in 38 aa overlap); and to the downstream ORF O33281|Rv2738c|MTV002.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (68 aa), FASTA scores: opt: 200, E(): 5.5e-05, (78.4% identity in 37 aa overlap). Questionable ORF. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts,Mb2762c and Mb2763c.	Q7TXZ8	No								IPR021408	Q7TXZ8	A0A1R3Y217									
NC_002945.3	Mycobrowser_v4	CDS	3012335	3012922	.	-	0	Mb2763c	Mb2763c		CONSERVED HYPOTHETICAL ARGININE RICH PROTEIN [FIRST PART]	Mb2763c, -, len: 195 aa. Equivalent to 5' end of Rv2742c, len: 277 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 195 aa overlap). Conserved hypothetical arg-rich protein. Extreme N-terminus is highly similar to the N-teminus of Q9CCC1ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 183, E(): 0.00052,(71.05% identity in 38 aa overlap); and to the downstream ORF O33281|Rv2738c|MTV002.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (68 aa), FASTA scores: opt: 200, E(): 5.5e-05, (78.4% identity in 37 aa overlap). Questionable ORF. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts,Mb2762c and Mb2763c.	Q7TXZ7	No									Q7TXZ7	A0A1R3Y225									
NC_002945.3	Mycobrowser_v4	CDS	3029211	3029483	.	-	0	Mb2783c	Mb2783c		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb2783c, -, len: 90 aa. Equivalent to 3' end of Rv2762c, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Conserved hypothetical protein, similar to C-terminus of hypothetical proteins: Q9A380|CC3324 from Caulobacter crescentus (409 aa), FASTA scores: opt: 181, E(): 9.8e-05,(43.55% identity in 101 aa overlap); Q98KQ4|MLR1373 from Rhizobium loti (Mesorhizobium loti) (399 aa), FASTA scores: opt: 174, E(): 0.00028, (46.35% identity in 82 aa overlap); and Q9HZZ9|PA2844 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 158, E(): 0.0033, (40.0% identity in 80 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis, a single base transition (c-t) splits Rv2762c into 2 parts, Mb2783c and Mb2784c.	Q7TXY0	No									Q7TXY0	A0A1R3Y239									
NC_002945.3	Mycobrowser_v4	CDS	3019390	3020208	.	+	0	Mb2771	Mb2771		PROBABLE DEHYDROGENASE	Mb2771, -, len: 272 aa. Equivalent to Rv2750, len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Probable dehydrogenase (EC 1.-.-.-), highly similar to other dehydrogenases/reductases e.g. Q9L5X5|COX CHOLESTEROL OXIDASE from Nocardioides simplex (Arthrobacter simplex) (270 aa), FASTA scores: opt: 836, E(): 1.8e-43, (55.7% identity in 264 aa overlap); Q9RA05|LIMC CARVEOL DEHYDROGENASE from Rhodococcus erythropolis (277 aa),FASTA scores: opt: 792, E(): 8.6e-41, (48.55% identity in 274 aa overlap); Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE from Streptomyces antibioticus (273 aa), FASTA scores: opt: 435, E(): 3.7e-19, (35.75% identity in 263 aa overlap); etc. Also highly similar to AAK44941MT0715 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Mycobacterium tuberculosis strain CDC1551 (275 aa), FASTA scores: opt: 702, E(): 2.4e-35, (44.45% identity in 270 aa overlap); and similar to many other Mycobacterium tuberculosis dehydrogenases.	Q7TXY9	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904,IPR023985	Q7TXY9	A0A1R3Y233				Rv2750		Rv2750			
NC_002945.3	Mycobrowser_v4	CDS	3020212	3021102	.	+	0	Mb2772	Mb2772		conserved protein	Mb2772, -, len: 296 aa. Equivalent to Rv2751, len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Conserved hypothetical protein, similar in part to others e.g. Q98LR1|MLR0915 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (299 aa), FASTA scores: opt: 279,E(): 1.6e-11, (32.85% identity in 210 aa overlap); Q9FBX1|SC8E7.10 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (283 aa), FASTA scores: opt: 232,E(): 2.4e-08, (27.9% identity in 269 aa overlap); Q9FMY9 HYPOTHETICAL PROTEIN (GENOMIC DNA, CHROMOSOME 5, P1 CLONE:MJB21) from Arabidopsis thaliana (Mouse-ear cress) (370 aa), FASTA scores: opt: 205, E(): 2.1e-06, (28.9% identity in 211 aa overlap); etc. Also similar in part to several proteins from Mycobacterium tuberculosis: P72053|Rv3787c|MTCY13D12.21 HYPOTHETICAL 33.4 KDA PROTEIN (308 aa), FASTA scores: opt: 266, E(): 1.3e-10, (29.6% identity in 267 aa overlap); O53795|MBE50c|Rv0731c|MTV041.05c HYPOTHETICAL 34.9 KDA PROTEIN (318 aa), FASTA scores: opt: 266, E(): 1.3e-10,(32.05% identity in 281 aa overlap); O53841|Rv0830|MTV043.22 HYPOTHETICAL 33.4 KDA PROTEIN (301 aa), FASTA scores: opt: 263, E(): 2e-10, (31.3% identity in 262 aa overlap); etc. BELONGS TO THE MTCY13D12.21 / MTCY210.45C / MTCY78.29C FAMILY.	Q7TXY8	No	conserved hypotheticals							IPR007213,IPR011610	Q7TXY8	A0A1R3Y226				Rv2751		Rv2751			
NC_002945.3	Mycobrowser_v4	CDS	3021089	3022765	.	-	0	Mb2773c	Mb2773c		CONSERVED HYPOTHETICAL PROTEIN	Mb2773c, -, len: 558 aa. Equivalent to Rv2752c,len: 558 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 558 aa overlap). Conserved hypothetical protein, equivalent to Q9CBW5|ML1512 HYPOTHETICAL PROTEIN from Mycobacterium leprae (558 aa),FASTA scores: opt: 3301, E(): 1.2e-195, (89.05% identity in 558 aa overlap). Also highly similar to other hypothetical proteins from a wide range of prokaryotes e.g. CAC19480|P54122|YOR4_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (718 aa), FASTA scores: opt: 2142, E(): 3.5e-124, (57.2% identity in 554 aa overlap) (N-terminus longer); O86842|SC9A10.09 from Streptomyces coelicolor (561 aa), FASTA scores: opt: 2077,E(): 2.9e-120, (55.95% identity in 556 aa overlap); Q9ZI80 from Streptomyces toyocaensis (528 aa), FASTA scores: opt: 1843, E(): 7.3e-106, (52.45% identity in 528 aa overlap) (N-terminus shorter 30 aa); etc.	Q7TXY7	No	conserved hypotheticals							IPR001279,IPR004613,IPR011108	Q7TXY7	A0A1R3Y230				Rv2752c		Rv2752c			
NC_002945.3	Mycobrowser_v4	CDS	3051660	3053423	.	+	0	Mb2810	Mb2810		CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN	Mb2810, -, len: 587 aa. Equivalent to Rv2787, len: 587 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 587 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q9CCI1|ML0798 HYPOTHETICAL PROTEIN from Mycobacterium leprae (592 aa),FASTA scores: opt: 2994, E(): 6.9e-179, (76.5% identity in 587 aa overlap); and similar in part to other proteins from Mycobacterium leprae e.g. O33082|MLCB628.11 HYPOTHETICAL 52.0 KDA PROTEIN (478 aa), FASTA scores: opt: 481, E(): 2.3e-22, (30.95% identity in 294 aa overlap). Also similar in part to O86637|SC3C3.03c HYPOTHETICAL 112.1 KDA PROTEIN from Streptomyces coelicolor (1083 aa),FASTA scores: opt: 488, E(): 1.5e-22, (28.95% identity in 297 aa overlap). And similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 625, E(): 2.2e-31, (34.05% identity in 320 aa overlap); O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 453,E(): 1.6e-20, (29.2% identity in 370 aa overlap); P96217|Rv3860|MTCY01A6.08c (390 aa), FASTA scores: opt: 443, E(): 4.7e-20, (29.95% identity in 354 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TXV7	No	conserved hypotheticals							IPR002586,IPR011990,IPR027417	Q7TXV7	A0A1R3Y2M0				Rv2787		Rv2787			
NC_002945.3	Mycobrowser_v4	CDS	3990946	3991422	.	-	0	Mb3635c	Mb3635c		PROBABLE CONSERVED SECRETED PROTEIN	Mb3635c, -, len: 158 aa. Equivalent to Rv3605c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Probable conserved secreted or membrane protein, identical to O69527|MLCB2548.04c|ML0227 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (158 aa), FASTA scores: opt: 944,E(): 2.6e-56, (85.45% identity in 158 aa overlap). Also similar to other proteins e.g. Q9X8I2|SCE9.09 POSSIBLE SECRETED PROTEIN from Streptomyces coelicolor (162 aa),FASTA scores: opt: 174, E(): 9.2e-05, (31.25% identity in 128 aa overlap); etc. Contains possible N-terminal signal sequence.	Q7TW39	No	cell wall and cell processes							IPR021517	Q7TW39	A0A1R3Y4M6				Rv3605c		Rv3605c			
NC_002945.3	Mycobrowser_v4	CDS	3031210	3031947	.	+	0	Mb2787	Mb2787		PROBABLE ALANINE RICH HYDROLASE	Mb2787, -, len: 245 aa. Equivalent to Rv2765, len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Probable ala-rich hydrolase (EC 3.-.-.-), similar to various hydrolases or hypothetical proteins e.g. Q9KYM6|SC9H11.13c PUTATIVE HYDROLASE from Streptomyces coelicolor (251 aa), FASTA scores: opt: 630, E(): 1.4e-33, (43.1% identity in 246 aa overlap); Q9A5T9|CC2358 DIENELACTONE HYDROLASE FAMILY PROTEIN from Caulobacter crescentus (286 aa), FASTA scores: opt: 592, E(): 4.5e-31, (38.45% identity in 242 aa overlap); Q9FCF1|2SCD46.33 PUTATIVE HYDROLASE (DIENELACTONE HYDROLASE FAMILY) from Streptomyces coelicolor (254 aa), FASTA scores: opt: 500, E(): 3.9e-25,(37.7% identity in 252 aa overlap); P73163|DLHH_SYNY3|SLL1298 PUTATIVE CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (EC 3.1.1.45) from Synechocystis sp. (strain PCC 6803) (246 aa), FASTA scores: opt: 276, E(): 1.3e-10, (26.95% identity in 230 aa overlap); etc.	Q7TXX8	No	intermediary metabolism and respiration							IPR002925	Q7TXX8	A0A1R3Y443				Rv2765		Rv2765			
NC_002945.3	Mycobrowser_v4	CDS	3032162	3032944	.	-	0	Mb2788c	Mb2788c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb2788c, -, len: 260 aa. Equivalent to Rv2766c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to others (from bacteria and eukaryota) e.g. Q9K3Y8|2SCG61.27c PUTATIVE SHORT CHAIN OXIDOREDUCTASE from Streptomyces coelicolor (253 aa), FASTA scores: opt: 722, E(): 7.4e-39,(44.75% identity in 248 aa overlap); Q93790|F54F3.4 HYPOTHETICAL SDR PROTEIN from Caenorhabditis elegans (260 aa), FASTA scores: opt: 613, E(): 6.9e-32, (41.7% identity in 247 aa overlap); O95162|O95162|SCAD-SRL PEROXISOMAL SHORT-CHAIN ALCOHOL DEHYDROGENASE from Homo sapiens (Human) (260 aa), FASTA scores: opt: 594, E(): 1.1e-30,(39.6% identity in 250 aa overlap); P51831|FABG_BACSU 3-OXOACYL-[ACYL-CARRIER PROTEIN] from Bacillus subtilis (246 aa), FASTA scores: opt: 504, E(): 4e-28, (37.2% identity in 247 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis acyl-carrier proteins e.g. MTCY03C7.07 (38.5% identity in 244 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Note that previously known as fabG5, a 3-oxoacyl-[acyl-carrier-protein].	Q7TXX7	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904	Q7TXX7	A0A1R3Y2Y3				Rv2766c		Rv2766c			
NC_002945.3	Mycobrowser_v4	CDS	3032941	3033294	.	-	0	Mb2789c	Mb2789c		POSSIBLE MEMBRANE PROTEIN	Mb2789c, -, len: 117 aa. Equivalent to Rv2767c,len: 117 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 117 aa overlap). Possible membrane protein, showing very weak similarity with Q9L2H7|SCC121.09 PUTATIVE METAL TRANSPORT ABC TRANSPORTER from Streptomyces coelicolor (256 aa), FASTA scores: opt: 110, E(): 1, (33.05% identity in 112 aa overlap). Questionable ORF.	Q7TXX6	No	cell wall and cell processes								Q7TXX6	A0A1R3Y2A7				Rv2767c		Rv2767c			
NC_002945.3	Mycobrowser_v4	CDS	3073370	3074050	.	+	0	Mb2835	Mb2835		PUTATIVE TRANSPOSASE [FIRST PART]	Mb2835, -, len: 226 aa. Similar to 5' end of Rv2812, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (92.4% identity in 224 aa overlap). Putative transposase for IS1604, similar to putative transposases and hypothetical proteins e.g. Q9EZM2|PUTATIVE TRANSPOSASE from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 329, E(): 3e-13, (27.05% identity in 362 aa overlap); CAC46499 PUTATIVE TRANSPOSASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (390 aa),FASTA scores: opt: 327, E(): 3.9e-13, (30.5% identity in 367 aa overlap); etc. Contains possible helix-turn-helix motif at aa 50-71 (Score 1140, +3.07 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (tg-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836.	Q7TXT4	No								IPR009057,IPR012337	Q7TXT4	A0A1R3Y2B1									
NC_002945.3	Mycobrowser_v4	CDS	3039948	3040877	.	-	0	Mb2798c	Mb2798c		PROBABLE OXIDOREDUCTASE	Mb2798c, -, len: 309 aa. Equivalent to Rv2776c,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to other oxidoreductases e.g. Q9KZ15|SC10B7.17 PUTATIVE IRON-SULFUR OXIDOREDUCTASE from Streptomyces coelicolor (364 aa),FASTA scores: opt: 846, E(): 1.2e-45, (46.75% identity in 308 aa overlap); O88034|SC5A7.28c IRON-SULFUR OXIDOREDUCTASE BETA SUBUNIT from Streptomyces coelicolor (313 aa), FASTA scores: opt: 745, E(): 2.3e-39, (41.45% identity in 316 aa overlap); P33164|PDR_BURCE|OPHA1 PHTHALATE DIOXYGENASE REDUCTASE from Burkholderia cepacia (Pseudomonas cepacia) (321 aa), FASTA scores: opt: 616,E(): 2.9e-31, (33.65% identity in 309 aa overlap); etc. Equivalent to AAK47165 from Mycobacterium tuberculosis strain CDC1551 (363 aa) but shorter 54 aa. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00063 Aldo/keto reductase family putative active site signature. SEEMS TO BELONG TO THE 2FE2S PLANT-TYPE FERREDOXIN FAMILY IN THE C-TERMINAL SECTION.	Q7TXW7	No	intermediary metabolism and respiration							IPR000951,IPR001041,IPR001433,IPR006058,IPR008333,IPR012675,IPR017927,IPR017938	Q7TXW7	A0A1R3Y2Z3				Rv2776c		Rv2776c			
NC_002945.3	Mycobrowser_v4	CDS	3037155	3037607	.	-	0	Mb2793c	Mb2793c		CONSERVED HYPOTHETICAL PROTEIN	Mb2793c, -, len: 150 aa. Equivalent to Rv2771c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Conserved hypothetical protein, equivalent to Q9CBV8|ML1525 HYPOTHETICAL PROTEIN from Mycobacterium leprae (151 aa), FASTA scores: opt: 489, E(): 1.7e-27, (52.7% identity in 148 aa overlap). Also highly similar to Q9RD46|SCF56.21 HYPOTHETICAL 15.7 KDA PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 671, E(): 2.2e-40, (67.8% identity in 146 aa overlap).	Q7TXX2	No	conserved hypotheticals							IPR005025	Q7TXX2	A0A1R3Y249				Rv2771c		Rv2771c			
NC_002945.3	Mycobrowser_v4	CDS	3424153	3424473	.	+	0	Mb3125A	Mb3125A		PemK-like protein	Mb3125A, len: 106 aa. Equivalent to Rv3098A len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 106 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). PemK-like protein.	X2BN25	No	virulence, detoxification, adaptation								X2BN25	A0A1R3Y342				Rv3098A		Rv3098A			
NC_002945.3	Mycobrowser_v4	CDS	3073980	3074777	.	+	0	Mb2836	Mb2836		PUTATIVE TRANSPOSASE [SECOND PART]	Mb2836, -, len: 265 aa. Equivalent to 3' end of Rv2812, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (99.623% identity in 265 aa overlap). Putative transposase for IS1604, similar to putative transposases and hypothetical proteins e.g. Q9EZM2|PUTATIVE TRANSPOSASE from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 329, E(): 3e-13, (27.05% identity in 362 aa overlap); CAC46499 PUTATIVE TRANSPOSASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (390 aa), FASTA scores: opt: 327,E(): 3.9e-13, (30.5% identity in 367 aa overlap); etc. Contains possible helix-turn-helix motif at aa 50-71 (Score 1140, +3.07 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (tg-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836.	Q7TXT3	No								IPR001584,IPR012337,IPR015378	Q7TXT3	A0A1R3Y486									
NC_002945.3	Mycobrowser_v4	CDS	3037693	3038166	.	-	0	Mb2794c	Mb2794c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2794c, -, len: 157 aa. Equivalent to Rv2772c,len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 157 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CBV7|ML1526 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 767, E(): 1.5e-43, (76.6% identity in 154 aa overlap); and similar to P46830|YDAB_MYCBO from Mycobacterium bovis (177 aa), FASTA scores: opt: 337, E(): 3.9e-15, (40.75% identity in 135 aa overlap). Also similar to O86837|SC9A10.04 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 338,E(): 3e-15, (43.75% identity in 144 aa overlap).	Q7TXX1	No	cell wall and cell processes								Q7TXX1	A0A1R3Y262				Rv2772c		Rv2772c			
NC_002945.3	Mycobrowser_v4	CDS	3038926	3039330	.	-	0	Mb2796c	Mb2796c		HYPOTHETICAL PROTEIN	Mb2796c, -, len: 134 aa. Equivalent to Rv2774c,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Hypothetical unknown protein.	Q7TXW9	No	conserved hypotheticals								Q7TXW9	A0A1R3Y271				Rv2774c		Rv2774c			
NC_002945.3	Mycobrowser_v4	CDS	3039483	3039944	.	+	0	Mb2797	Mb2797		gcn5-related n-acetyltransferase	Mb2797, -, len: 153 aa. Equivalent to Rv2775, len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Hypothetical unknown protein, showing weak similarity with hypothetical proteins e.g. Q9ZBJ7|SC9C7.13c from Streptomyces coelicolor (179 aa), FASTA scores: opt: 167, E(): 0.00024,(29.05% identity in 148 aa overlap). Equivalent to AAK47164 from Mycobacterium tuberculosis strain CDC1551 (185 aa) but shorter 32 aa.	Q7TXW8	No	intermediary metabolism and respiration							IPR000182,IPR016181	Q7TXW8	A0A1R3Y455				Rv2775		Rv2775			
NC_002945.3	Mycobrowser_v4	CDS	3245037	3246278	.	+	0	Mb2968	Mb2968		PROBABLE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1533	Mb2968, -, len: 413 aa. Equivalent to Rv2943, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable transposase for insertion sequence IS1533, similar to other transposases e.g. P15025|ISTA_ECOLI ista protein (insertion sequence IS21) from Escherichia coli (390 aa),FASTA scores: opt: 268, E(): 5.1e-11, (24.1% identity in 378 aa overlap). Contains potential helix-turn-helix motif at aa 19-40 (Score 1611, +4.67 SD).	Q7TXL0	No	insertion seqs and phages							IPR001584,IPR011991,IPR012337,IPR013249	Q7TXL0	A0A1R3Y2M3				Rv2943		Rv2943			
NC_002945.3	Mycobrowser_v4	CDS	3041059	3042129	.	-	0	Mb2799c	Mb2799c		CONSERVED HYPOTHETICAL PROTEIN	Mb2799c, -, len: 356 aa. Equivalent to Rv2777c,len: 356 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Conserved hypothetical protein, highly similar (but longer in N-terminus) to hypothetical proteins Q9KZ16|SC10B7.16 from Streptomyces coelicolor (296 aa), FASTA scores: opt: 980,E(): 6.8e-57, (51.25% identity in 281 aa overlap); and Q9HYS0|PA3325 from Pseudomonas aeruginosa (295 aa), FASTA scores: opt: 816, E(): 4e-46, (43.75% identity in 288 aa overlap); and similar (but longer in N-terminus) to other hypothetical proteins e.g. Q9I3H1|PA1542 from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 234, E(): 6.3e-08,(31.8% identity in 258 aa overlap). Equivalent to AAK47166 from Mycobacterium tuberculosis strain CDC1551 (393 aa) but shorter 37 aa.	Q7TXW6	No	conserved hypotheticals							IPR016516	Q7TXW6	A0A1R3Y2B7				Rv2777c		Rv2777c			
NC_002945.3	Mycobrowser_v4	CDS	4330558	4334112	.	+	0	Mb3940	Mb3940		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3940, -, len: 1184 aa. Equivalent to Rv3910, len: 1184 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1184 aa overlap). Probable conserved transmembrane protein (hydrophobic domain ~50-550),equivalent to Q9CCX9|ML2700 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (1206 aa), FASTA scores: opt: 5554, E(): 0, (75.15% identity in 1182 aa overlap); and highly similar, but shorter 380 aa, to Q50199|L222-ORF10 from Mycobacterium leprae (784 aa) FASTA scores: opt: 3297, E(): 5.5e-170, (68.8% identity in 769 aa overlap); and at the N-terminal end with Q50198|L222-ORF also from Mycobacterium leprae (379 aa) FASTA scores: opt: 1955, E(): 5.7e-98, (88.4% identity in 353 aa overlap) (ORFs 9 and 10 are adjacent on L222). Also similar in part (principally at the N-terminal end) to other membrane proteins e.g. Q9X8T0|SCH24.16c PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (811 aa), FASTA scores: opt: 573, E(): 2.8e-23, (31.05% identity in 573 aa overlap); O05467|MVIN_RHITR INTEGRAL MEMBRANE PROTEIN VIRULENCE FACTOR MVIN HOMOLOG from Rhizobium tropici (533 aa), FASTA scores: opt: 468, E(): 9e-18, (27.1% identity in 524 aa overlap); P56882|MVIN_RHIME INTEGRAL MEMBRANE PROTEIN VIRULENCE FACTOR MVIN HOMOLOG from Rhizobium meliloti (Sinorhizobium meliloti) (535 aa), FASTA scores: opt: 453, E(): 5.8e-17,(26.2% identity in 557 aa overlap); etc.	Q7TVD1	No	cell wall and cell processes							IPR004268,IPR008979,IPR011009	Q7TVD1	A0A1R3Y5M2				Rv3910		Rv3910			
NC_002945.3	Mycobrowser_v4	CDS	3168319	3168624	.	-	0	Mb2925c	Mb2925c		conserved protein	Mb2925c, -, len: 101 aa. Equivalent to Rv2901c,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Conserved hypothetical protein, very equivalent to O33023|ML1610|MLCB250.41 HYPOTHETICAL 12.3 KDA PROTEIN from Mycobacterium leprae (101 aa), FASTA scores: opt: 658, E(): 2.6e-43, (99.0% identity in 101 aa overlap). Also highly similar to O69889|SC2E1.18 HYPOTHETICAL PROTEIN from Streptomyces coelicolor and Streptomyces lividans (102 aa), FASTA scores: opt: 515, E(): 2.2e-32,(75.0% identity in 100 aa overlap).	X2BLU8	No	conserved hypotheticals								X2BLU8	P65052				Rv2901c		Rv2901c			
NC_002945.3	Mycobrowser_v4	CDS	3042287	3042757	.	-	0	Mb2800c	Mb2800c		conserved protein	Mb2800c, -, len: 156 aa. Equivalent to Rv2778c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, similar to Q9CBF7|ML2031 HYPOTHETICAL PROTEIN from Mycobacterium leprae (151 aa),FASTA scores: opt: 227, E(): 8.5e-09, (35.95% identity in 153 aa overlap). Also similar to AAK46204|MT1931.1 HYPOTHETICAL 17.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (158 aa), FASTA scores: opt: 238, E(): 1.5e-09, (35.75% identity in 151 aa overlap); or O07748|Rv1883c|MTCY180.35 HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (158 aa),FASTA scores: opt: 212, E(): 9.7e-08, (34.45% identity in 151 aa overlap); note that AAK46204|MT1931.1 and O07748|Rv1883c|MTCY180.35 are essentially the same protein except for a small (5 aa) gap.	Q7TXW5	No	conserved hypotheticals							IPR019587,IPR023393	Q7TXW5	A0A1R3Y2L0				Rv2778c		Rv2778c			
NC_002945.3	Mycobrowser_v4	CDS	3042789	3043304	.	-	0	Mb2801c	Mb2801c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LRP/ASNC-FAMILY)	Mb2801c, -, len: 171 aa. Equivalent to Rv2779c,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(94.475% identity in 179 aa overlap). Possible transcriptional regulator, from the Lrp/AsnC family,similar (but longer ~30 aa in N-terminus) to others e.g. CAC42842|SCBAC36F5.06 PUTATIVE ASNC-FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (163 aa),FASTA scores: opt: 333, E(): 4.4e-16, (39.7% identity in 141 aa overlap); O07920|AZLB_BACSU TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Bacillus subtilis; Q9I233|PA2082 PROBABLE TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 322, E(): 2.5e-15, (33.1% identity in 148 aa overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (33.3% identity in 120 aa overlap). Equivalent to AAK47168 from Mycobacterium tuberculosis strain CDC1551 (181 aa). SEEMS TO BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS. Start changed since first submission (+8 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa).	Q7TXW4	No	regulatory proteins							IPR000485,IPR011008,IPR011991,IPR019887,IPR019888	Q7TXW4	A0A1R3Y261				Rv2779c		Rv2779c			
NC_002945.3	Mycobrowser_v4	CDS	3044499	3045533	.	-	0	Mb2804c	Mb2804c		POSSIBLE ALANINE RICH OXIDOREDUCTASE	Mb2804c, -, len: 344 aa. Equivalent to Rv2781c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Possible ala-rich oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases or hypothetical proteins e.g. Q9RDD8|SCC77.20c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (364 aa), FASTA scores: opt: 912, E(): 5.3e-47,(45.55% identity in 336 aa overlap); Q9FDD4|2-NPDL PUTATIVE 2-NITROPROPANE DIOXYGENASE from Streptomyces ansochromogenes (363 aa), FASTA scores: opt: 869, E(): 1.9e-44, (44.2% identity in 337 aa overlap); O05413|YRPB 2-NITROPROPANE DIOXYGENASE from Bacillus subtilis (347 aa), FASTA scores: opt: 560, E(): 4.9e-26, (33.75% identity in 317 aa overlap); etc.	Q7TXW1	No	intermediary metabolism and respiration							IPR004136,IPR013785	Q7TXW1	A0A1R3Y272				Rv2781c		Rv2781c			
NC_002945.3	Mycobrowser_v4	CDS	3056751	3058130	.	-	0	Mb2814c	Mb2814c		PROBABLE TRANSPOSASE	Mb2814c, -, len: 459 aa. Equivalent to Rv2791c,len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable IS1602 transposase for IS1602 element, similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa), FASTA scores: opt: 2718, E(): 6.3e-165, (86.05% identity in 459 aa overlap).	Q7TXV3	No	insertion seqs and phages							IPR001959,IPR010095,IPR021027	Q7TXV3	A0A1R3Y281				Rv2791c		Rv2791c			
NC_002945.3	Mycobrowser_v4	CDS	3063860	3064186	.	-	0	Mb2821c	Mb2821c		CONSERVED HYPOTHETICAL PROTEIN	Mb2821c, -, len: 108 aa. Equivalent to Rv2798c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Conserved hypothetical ala-rich protein, similar to P71545|Y965_MYCTU|Rv0965c|MT0993|MTCY10D7.09 HYPOTHETICAL 14.5 KDA PROTEIN from Mycobacterium tuberculosis (139 aa),FASTA scores: opt: 198, E(): 8e-07, (38.9% identity in 90 aa overlap).	Q7TXU7	No	conserved hypotheticals							IPR010310	Q7TXU7	A0A1R3Y274				Rv2798c		Rv2798c			
NC_002945.3	Mycobrowser_v4	CDS	3060486	3061460	.	-	0	Mb2818c	Mb2818c		CONSERVED HYPOTHETICAL PROTEIN	Mb2818c, -, len: 324 aa. Equivalent to Rv2795c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Conserved hypothetical protein, equivalent to Q9Z5I6|ML1548|MLCB596.22 HYPOTHETICAL 37.5 KDA PROTEIN from Mycobacterium leprae (321 aa), FASTA scores: opt: 2018, E(): 6.3e-128, (87.4% identity in 318 aa overlap). Also highly similar to O88028|SC5A7.22 HYPOTHETICAL 33.5 KDA PROTEIN from Streptomyces coelicolor (295 aa), FASTA scores: opt: 1202, E(): 3.4e-73, (57.2% identity in 285 aa overlap); and Q9AMH7|SIMX4 SIMX4 PROTEIN from Streptomyces antibioticus (293 aa), FASTA scores: opt: 1045, E(): 1.2e-62, (51.4% identity in 286 aa overlap). C-terminus highly similar to Q9F0Q7 HYPOTHETICAL 9.6 KDA PROTEIN (FRAGMENT) from Streptomyces verticillus (81 aa), FASTA scores: opt: 395, E(): 1.8e-19, (68.35% identity in 79 aa overlap). Also similar to other proteins e.g. Q9FWV7 HYPOTHETICAL 45.3 KDA PROTEIN from Oryza sativa (Rice) (402 aa), FASTA scores: opt: 294, E(): 3.6e-12, (26.45% identity in 340 aa overlap).	Q7TXV0	No	conserved hypotheticals							IPR004843	Q7TXV0	A0A1R3Y311				Rv2795c		Rv2795c			
NC_002945.3	Mycobrowser_v4	CDS	2189658	2190059	.	+	0	Mb1982	Mb1982		HYPOTHETICAL PROTEIN	Mb1982, -, len: 133 aa. Equivalent to Rv1947, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Hypothetical unknown protein	Q7TZ85,A0A1R3Y0K9	No	conserved hypotheticals			A0A1R3Y0K9					Q7TZ85					Rv1947		Rv1947			
NC_002945.3	Mycobrowser_v4	CDS	3062168	3063856	.	-	0	Mb2820c	Mb2820c		CONSERVED HYPOTHETICAL PROTEIN	Mb2820c, -, len: 562 aa. Equivalent to Rv2797c,len: 562 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 562 aa overlap). Conserved hypothetical ala-rich protein. C-terminus highly similar to several mycobacterial proteins e.g. AAK46927|MT2616 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa), FASTA scores: opt: 535, E(): 4.6e-22, (42.95% identity in 263 aa overlap); P95011|Rv2542|MTCY159.14c HYPOTHETICAL 42.4 KDA PROTEIN from Mycobacterium tuberculosis (403 aa), FASTA scores: opt: 537, E(): 5e-22, (40.75% identity in 292 aa overlap) (similarity in the second half of protein); P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 HYPOTHETICAL 28.1 KDA PROTEIN (266 aa), FASTA scores: opt: 314, E(): 5.7e-10, (39.0% identity in 254 aa overlap); etc. Contains PS00120 Lipases, serine active site.	Q7TXU8	No	conserved hypotheticals							IPR010427	Q7TXU8	A0A1R3Y2N0				Rv2797c		Rv2797c			
NC_002945.3	Mycobrowser_v4	CDS	3064968	3066617	.	+	0	Mb2823	Mb2823		POSSIBLE HYDROLASE	Mb2823, -, len: 549 aa. Equivalent to Rv2800, len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 549 aa overlap). Possible hydrolase (EC 3.-.-.-), an esterase (EC 3.1.1.-) or an acylase (EC 3.-.-.-). Similar, but longer in N-terminus, to esterases or acylases e.g. Q9L9D7|COCE COCAINE ESTERASE from Rhodococcus sp. MB1 'Bresler 1999' (574 aa), FASTA scores: opt: 510, E(): 3.1e-23, (33.6% identity in 571 aa overlap); Q9L3U2|STTE PUTATIVE ACYLASE from Streptomyces rochei (Streptomyces parvullus) (554 aa), FASTA scores: opt: 492, E(): 3.7e-22, (34.45% identity in 569 aa overlap); CAC49652|SMB21424 PUTATIVE ESTERASE OR ACYLASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (578 aa), FASTA scores: opt: 405, E(): 7.1e-17, (34.45% identity in 569 aa overlap); etc.	Q7TXU5	No	intermediary metabolism and respiration							IPR000383,IPR005674,IPR008979,IPR013736	Q7TXU5	A0A1R3Y288				Rv2800		Rv2800			
NC_002945.3	Mycobrowser_v4	CDS	3067332	3068375	.	-	0	Mb2825c	Mb2825c		HYPOTHETICAL ARGININE AND ALANINE RICH PROTEIN	Mb2825c, -, len: 347 aa. Equivalent to Rv2802c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Hypothetical unknown arg-, ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 138, E(): 0.12, (37.35% identity in 91 aa overlap); and CAC47718|SMC03294 from Rhizobium meliloti (Sinorhizobium meliloti) (114 aa),FASTA scores: opt: 128, E(): 0.53, (31.4% identity in 86 aa overlap). Equivalent to AAK47191 from Mycobacterium tuberculosis strain CDC1551 (357 aa) but shorter 10 aa.	Q7TXU3	No	conserved hypotheticals							IPR018744	Q7TXU3	A0A1R3Y2A2				Rv2802c		Rv2802c			
NC_002945.3	Mycobrowser_v4	CDS	3069017	3069646	.	-	0	Mb2827c	Mb2827c		HYPOTHETICAL PROTEIN	Mb2827c, -, len: 209 aa. Equivalent to Rv2804c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 209 aa overlap). Hypothetical unknown protein, overlaps neighbouring ORF Rv2805|MTCY16B7.38c.	Q7TXU1	No	conserved hypotheticals								Q7TXU1	A0A1R3Y322				Rv2804c		Rv2804c			
NC_002945.3	Mycobrowser_v4	CDS	3069419	3069823	.	+	0	Mb2828	Mb2828		CONSERVED HYPOTHETICAL PROTEIN	Mb2828, -, len: 134 aa. Equivalent to Rv2805, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Conserved hypothetical protein, highly similar to N-terminal region of downstream ORF P71644|Rv2807|MTCY16B7.36c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 525, E(): 6.4e-29, (78.2% identity in 101 aa overlap). Also highly similar to N-terminus of other proteins: Q9KK74 HYPOTHETICAL 47.4 KDA PROTEIN from Brevibacterium linens (418 aa), FASTA scores: opt: 480,E(): 8.8e-26, (64.15% identity in 106 aa overlap); AAK40065 Rv3128c-LIKE PROTEIN from Mycobacterium celatum (423 aa), FASTA scores: opt: 218, E(): 1.2e-07, (46.05% identity in 89 aa overlap); Q981U5|MLR9230 from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 131, E(): 0.15, (29.4% identity in 126 aa overlap). Overlaps neighbouring ORF Rv2804c|MTCY16B7.39.	Q7TXU0	No	conserved hypotheticals								Q7TXU0	A0A1R3Y2E9				Rv2805		Rv2805			
NC_002945.3	Mycobrowser_v4	CDS	3070210	3071364	.	+	0	Mb2830	Mb2830		CONSERVED HYPOTHETICAL PROTEIN	Mb2830, -, len: 384 aa. Equivalent to Rv2807, len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 384 aa overlap). Conserved hypothetical protein, highly similar, but shorter 35 aa, to Q9KK74 HYPOTHETICAL 47.4 KDA PROTEIN from Brevibacterium linens (418 aa), FASTA scores: opt: 1865, E(): 9.4e-116, (69.75% identity in 380 aa overlap); and with similarity with other hypothetical proteins or transposases e.g. Q981U5|MLR9230 PROTEIN from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 636,, (36.05% identity in 377 aa overlap); CAC47689 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ISRM18 from Rhizobium meliloti (Sinorhizobium meliloti) (507 aa), FASTA scores: opt: 553,E(): 6.6e-29, (33.5% identity in 370 aa overlap); etc. Also similar to Rv3128c|MTCY164.38c (336 aa) (47.2% identity in 339 aa overlap); and high similarity at N-terminal region with Rv2805|MTCY16B7.38c (79.2% identity in 101 aa overlap).	Q7TXT8	No	conserved hypotheticals							IPR001584,IPR012337	Q7TXT8	A0A1R3Y284				Rv2807		Rv2807			
NC_002945.3	Mycobrowser_v4	CDS	3077046	3077882	.	-	0	Mb2838c	Mb2838c		PROBABLE TRANSPOSASE	Mb2838c, -, len: 278 aa. Equivalent to Rv2814c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Probable transposase,highly similar to others e.g. P97137|Rv0796|MTV042.06 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS986/IS6110 from Mycobacterium tuberculosis (328 aa),FASTA scores: opt: 2103, E(): 6.1e-132, (100.0% identity in 312 aa overlap); etc. Start unlikely.	X2BLY7,P59800	No	insertion seqs and phages								X2BLY7,P59800	P59800				Rv2814c		Rv2814c			
NC_002945.3	Mycobrowser_v4	CDS	3072691	3073299	.	+	0	Mb2834	Mb2834		CONSERVED HYPOTHETICAL PROTEIN	Mb2834, -, len: 202 aa. Equivalent to Rv2811, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Conserved hypothetical protein. C-terminus equivalent to C-terminus of AAK47198|MT2878 HYPOTHETICAL 17.7 KDA PROTEIN Mycobacterium tuberculosis strain CDC1551 (178 aa), FASTA scores: opt: 609, E(): 1.5e-32, (61.0% identity in 182 aa overlap); and C-terminus highly similar to P72038|Rv3771c|MTCY13D12.05c HYPOTHETICAL 11.3 KDA PROTEIN from Mycobacterium tuberculosis (108 aa), FASTA scores: opt: 465, E(): 2.8e-23, (73.6% identity in 106 aa overlap). Also some similarity with P71962|Rv2665|MTCY441.34 HYPOTHETICAL 10.5 KDA PROTEIN from Mycobacterium tuberculosis (93 aa), FASTA scores: opt: 153, E(): 0.0057, (39.05% identity in 64 aa overlap); and Q9A6W6|CC1966 HYPOTHETICAL PROTEIN CC1966 from Caulobacter crescentus (189 aa), FASTA scores: opt: 115,E(): 2.6, (39.4% identity in 104 aa overlap).	Q7TXT5	No	conserved hypotheticals								Q7TXT5	A0A1R3Y292				Rv2811		Rv2811			
NC_002945.3	Mycobrowser_v4	CDS	3074774	3075586	.	+	0	Mb2837	Mb2837		CONSERVED HYPOTHETICAL PROTEIN	Mb2837, -, len: 270 aa. Equivalent to Rv2813, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 270 aa overlap). Conserved hypothetical protein, similar to various proteins (notably secreted proteins) e.g. Q9ZFL2 HYPOTHETICAL 30.4 KDA PROTEIN from Bacillus stearothermophilus (266 aa), FASTA scores: opt: 518, E(): 1.4e-26, (33.85% identity in 266 aa overlap); P45754|GSPA_AERHY|EXEA GENERAL SECRETION PATHWAY PROTEIN from Aeromonas hydrophila (547 aa), FASTA scores: opt: 386, E(): 1.1e-17, (32.05% identity in 265 aa overlap); Q9KPC7|VC2445 GENERAL SECRETION PATHWAY PROTEIN A from Vibrio cholerae (529 aa), FASTA scores: opt: 366, E(): 2.2e-16, (31.1% identity in 270 aa overlap); Q56674|VC0403 MANNOSE-SENSITIVE HEMAGGLUTININ D from Vibrio cholerae (281 aa), FASTA scores: opt: 317, E(): 2.1e-13, (27.85% identity in 262 aa overlap); etc. Also highly similar to AAK40072 Rv2813-LIKE PROTEIN from Mycobacterium celatum (270 aa), FASTA scores: opt: 1628, E(): 2.8e-99, (90.75% identity in 270 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TXT2	No	conserved hypotheticals							IPR027417	Q7TXT2	A0A1R3Y331				Rv2813		Rv2813			
NC_002945.3	Mycobrowser_v4	CDS	3080187	3080528	.	-	0	Mb2840c	Mb2840c		CONSERVED HYPOTHETICAL PROTEIN	Mb2840c, -, len: 113 aa. Equivalent to Rv2816c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Conserved hypothetical protein, highly similar in part to N-terminus of several proteins e.g. O28403|AF1876 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (94 aa),FASTA scores: opt: 137, E(): 0.0022, (47.55% identity in 61 aa overlap); Q97Y85|SSO8090 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (88 aa), FASTA scores: opt: 124,E(): 0.02, (37.3% identity in 59 aa overlap); etc.	Q7TXT1	No	conserved hypotheticals							IPR000640,IPR019199,IPR021127	Q7TXT1	A0A1R3Y289				Rv2816c		Rv2816c			
NC_002945.3	Mycobrowser_v4	CDS	3080529	3081545	.	-	0	Mb2841c	Mb2841c		CONSERVED HYPOTHETICAL PROTEIN	Mb2841c, -, len: 338 aa. Equivalent to Rv2817c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 338 aa overlap). Conserved hypothetical protein, showing similarity with O30236|AF2435 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (322 aa), FASTA scores: opt: 397,E(): 2.4e-19, (28.2% identity in 298 aa overlap); Q9KFX9|BH0341 HYPOTHETICAL PROTEIN from Bacillus halodurans (343 aa), FASTA scores: opt: 337, E(): 2.8e-15,(27.35% identity in 300 aa overlap); Q9X2B7|TM1797 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (319 aa), FASTA scores: opt: 321, E(): 3.3e-14, (26.5% identity in 268 aa overlap); etc.	Q7TXT0	No	conserved hypotheticals							IPR002729	Q7TXT0	A0A1R3Y290				Rv2817c		Rv2817c			
NC_002945.3	Mycobrowser_v4	CDS	3081795	3082706	.	-	0	Mb2842c	Mb2842c		hypothetical protein	Mb2842c, -, len: 303 aa. Equivalent to 5' end of Rv2818c, len: 382 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 303 aa overlap). Hypothetical unknown protein, equivalent to AAK47210 from Mycobacterium tuberculosis strain CDC1551 (430 aa) but shorter 48 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (303 aa versus 382 aa).	Q7TXS9	No								IPR013489	Q7TXS9	A0A1R3Y2B3									
NC_002945.3	Mycobrowser_v4	CDS	3082802	3083929	.	-	0	Mb2843c	Mb2843c		HYPOTHETICAL PROTEIN	Mb2843c, -, len: 375 aa. Equivalent to Rv2819c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Hypothetical unknown protein (see citations below).	Q7TXS8	No	conserved hypotheticals							IPR005537,IPR010173	Q7TXS8	A0A1R3Y2A4				Rv2819c		Rv2819c			
NC_002945.3	Mycobrowser_v4	CDS	2190348	2190698	.	-	0	Mb1983c	Mb1983c		HYPOTHETICAL PROTEIN	Mb1983c, -, len: 116 aa. Equivalent to Rv1948c,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 116 aa overlap). Hypothetical unknown protein	Q7TZ84,A0A1R3XZU5	No	conserved hypotheticals			A0A1R3XZU5					Q7TZ84					Rv1948c		Rv1948c			
NC_002945.3	Mycobrowser_v4	CDS	3085906	3088344	.	-	0	Mb2847c	Mb2847c		conserved protein	Mb2847c, -, len: 812 aa. Equivalent to Rv2823c,len: 809 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 812 aa overlap). Conserved hypothetical protein, similar in part to others e.g. Q9X2D1|TM1811Thermotoga maritima (717 aa), FASTA scores: opt: 401, E(): 3.6e-18, (27.15% identity in 773 aa overlap); O27154|MTH1082 CONSERVED HYPOTHETICAL PROTEIN from Methanothermobacter thermautotrophicus (822 aa),FASTA scores: opt: 306, E(): 6e-12, (25.55% identity in 872 aa overlap); Q59066|MJ1672 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (800 aa), FASTA scores: opt: 302,E(): 1.1e-11, (24.9% identity in 812 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp insertion (*-cggcgatgt) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TXS4	No	conserved hypotheticals							IPR000160,IPR006674,IPR013408	Q7TXS4	A0A1R3Y339				Rv2823c		Rv2823c			
NC_002945.3	Mycobrowser_v4	CDS	3088341	3089285	.	-	0	Mb2848c	Mb2848c		HYPOTHETICAL PROTEIN	Mb2848c, -, len: 314 aa. Equivalent to Rv2824c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 314 aa overlap). Hypothetical unknown protein.	Q7TXS3	No	conserved hypotheticals							IPR010156,IPR019267	Q7TXS3	A0A1R3Y2H0				Rv2824c		Rv2824c			
NC_002945.3	Mycobrowser_v4	CDS	3246278	3246808	.	+	0	Mb2969	Mb2969		POSSIBLE TRANSPOSASE	Mb2969, -, len: 176 aa. Equivalent to Rv2943A, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Possible transposase,similar to many e.g. AJ238712|MBO238712_2 PUTATIVE TRANSPOSASE (IS21-l) from Mycobacterium bovis BCG (266 aa), FASTA scores: opt: 762, E(): 0, (100.0% identity in 118 aa overlap). Possible frameshift after codon 118 i.e. near position 3290056, to fuse with Rv2944.	Q7TXK9	No	insertion seqs and phages							IPR002611	Q7TXK9	A0A1R3Y2N8				Rv2943A		Rv2943A			
NC_002945.3	Mycobrowser_v4	CDS	3089463	3090110	.	-	0	Mb2849c	Mb2849c		CONSERVED HYPOTHETICAL PROTEIN	Mb2849c, -, len: 215 aa. Equivalent to Rv2825c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(97.7% identity in 215 aa overlap). Conserved hypothetical protein, similar to Q9RY53|DR0097 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FASTA scores: opt: 261, E(): 8e-11, (33.5% identity in 176 aa overlap); and shows some similarity with N-terminus of O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN from Methanothermobacter thermautotrophicus (340 aa), FASTA scores: opt: 133, E(): 0.091, (28.55% identity in 112 aa overlap). Equivalent to AAK47217 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 31 aa; and equivalent to upstream ORF P71624|Rv2828c|MTCY16B7.14 from Mycobacterium tuberculosis strain H37Rv (alias AAK47221 from strain CDC1551) (181 aa), FASTA scores: opt: 1169, E(): 8.5e-74, (98.35% identity in 181 aa overlap).	Q7TXS2	No	conserved hypotheticals							IPR008307,IPR014923	Q7TXS2	A0A1R3Y2Q8				Rv2825c		Rv2825c			
NC_002945.3	Mycobrowser_v4	CDS	3090280	3091164	.	-	0	Mb2850c	Mb2850c		HYPOTHETICAL PROTEIN	Mb2850c, -, len: 294 aa. Equivalent to Rv2826c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Hypothetical unknown protein.	Q7TXS1	No	conserved hypotheticals							IPR014942	Q7TXS1	A0A1R3Y2A1				Rv2826c		Rv2826c			
NC_002945.3	Mycobrowser_v4	CDS	3091167	3092054	.	-	0	Mb2851c	Mb2851c		HYPOTHETICAL PROTEIN	Mb2851c, -, len: 295 aa. Equivalent to Rv2827c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Hypothetical unknown protein, equivalent to AAK47219 from Mycobacterium tuberculosis strain CDC1551 (315 aa) but shorter 20 aa.	Q7TXS0	No	conserved hypotheticals							IPR018547	Q7TXS0	A0A1R3Y299				Rv2827c		Rv2827c			
NC_002945.3	Mycobrowser_v4	CDS	3092359	3092904	.	-	0	Mb2852c	Mb2852c		CONSERVED HYPOTHETICAL PROTEIN	Mb2852c, -, len: 181 aa. Equivalent to Rv2828c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 181 aa overlap). Conserved hypothetical protein, similar to Q9RY53|DR0097 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FASTA scores: opt: 267, E(): 1.9e-11, (34.1% identity in 176 aa overlap); and shows some similarity with N-terminus of O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN from Methanothermobacter thermautotrophicus (340 aa), FASTA scores: opt: 133, E(): 0.07, (28.55% identity in 112 aa overlap). Also equivalent to downstream ORF P71627|Rv2825c|MTCY16B7.17 from Mycobacterium tuberculosis strain H37Rv (alias AAK47217 from strain CDC1551, 246 aa) (215 aa), FASTA scores: opt: 1173, E(): 8.3e-75, (98.9% identity in 181 aa overlap).	Q7TXR9	No	conserved hypotheticals							IPR008307,IPR014923	Q7TXR9	A0A1R3Y2C7				Rv2828c		Rv2828c			
NC_002945.3	Mycobrowser_v4	CDS	3092901	3093170	.	-	0	Mb2852A	Mb2852A		Conserved hypothetical protein	Mb2852A, len: 89 aa. Equivalent to Rv2828A len: 89 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein,present in many mycobacteria. Equivalent to BCG2848c and Mb2852A (100% identity to both in 89 aa overlap)	X2BM00	No	conserved hypotheticals								X2BM00	A0A1R3Y2B0				Rv2828A		Rv2828A			
NC_002945.3	Mycobrowser_v4	CDS	3104529	3104828	.	-	0	Mb2865c	Mb2865c		CONSERVED HYPOTHETICAL PROTEIN	Mb2865c, -, len: 99 aa. Equivalent to Rv2840c, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein, equivalent to Q9Z5J0|ML1557|MLCB596.13 HYPOTHETICAL 11.6 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 501, E(): 2.3e-29, (501% identity in 96 aa overlap). Also highly similar to other hypothetical proteins e.g. Q9KYR0|SC5H4.29 from Streptomyces coelicolor (101 aa), FASTA scores: opt: 256,E(): 1.4e-11, (50.6% identity in 81 aa overlap); Q9APM9 from Myxococcus xanthus (111 aa), FASTA scores: opt: 174,E(): 1.3e-05, (42.25% identity in 97 aa overlap); and similar to to others e.g. N-terminus of CAC41675|SMC02913 from Rhizobium meliloti (Sinorhizobium meliloti) (230 aa),FASTA scores: opt: 172, E(): 3e-05, (42.4% identity in 66 aa overlap).	Q7TXQ8	No	conserved hypotheticals							IPR007393	Q7TXQ8	A0A1R3Y4A8				Rv2840c		Rv2840c			
NC_002945.3	Mycobrowser_v4	CDS	3100205	3101215	.	-	0	Mb2862c	Mb2862c		conserved protein	Mb2862c, -, len: 336 aa. Equivalent to Rv2837c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Conserved hypothetical protein, showing some similarity with other proteins e.g. O67552|AQ_1630 HYPOTHETICAL 36.2 KDA PROTEIN from Aquifex aeolicus (325 aa), FASTA scores: opt: 498,E(): 3.6e-25, (32.8% identity in 314 aa overlap); Q9X1T1|TM1595 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (333 aa), FASTA scores: opt: 482, E(): 4.1e-24, (34.85% identity in 304 aa overlap); Q9RW43|DR0826 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (338 aa), FASTA scores: opt: 444,E(): 1.3e-21, (33.85% identity in 331 aa overlap); etc. Equivalent to AAK47229 from Mycobacterium tuberculosis strain CDC1551 (316 aa) but longer 20 aa.	Q7TXQ9	No	conserved hypotheticals							IPR001667,IPR003156	Q7TXQ9	A0A1R3Y2C0				Rv2837c		Rv2837c			
NC_002945.3	Mycobrowser_v4	CDS	3127236	3128162	.	-	0	Mb2884c	Mb2884c		POSSIBLE AMIDOTRANSFERASE	Mb2884c, -, len: 308 aa. Equivalent to Rv2859c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Possible amidotransferase (EC 6.3.5.- or 2.-.-.-), equivalent (but longer 58 aa) to Q9CBU9|ML1573 POSSIBLE AMIDOTRANSFERASE from Mycobacterium leprae (249 aa), FASTA scores: opt: 1226, E(): 3e-64, (71.55% identity in 239 aa overlap). Also similar to other amidotransferases and hypothetical proteins, but shorter in N-terminus e.g. O88072|SCI35.37 HYPOTHETICAL 25.3 KDA PROTEIN from Streptomyces coelicolor (242 aa), FASTA scores: opt: 683, E(): 1.2e-32, (47.65% identity in 235 aa overlap); AAK79730|Q97I88|CAC1764 PREDICTED GLUTAMINE AMIDOTRANSFERASE from Clostridium acetobutylicum (241 aa), FASTA scores: opt: 458, E(): 1.6e-19, (32.95% identity in 246 aa overlap); AAK75201|Q97QV9|SP1089 GLUTAMINE AMIDOTRANSFERASE CLASS I from Streptococcus pneumoniae (229 aa), FASTA scores: opt: 431, E(): 5.6e-18, (34.75% identity in 236 aa overlap); etc. Contains three 17 aa repeats at the N-terminus very similar to those in other Mycobacterium tuberculosis proteins e.g. Q10699|YY30_MYCTU|Rv2090|MT2151|MTCY49.30 PUTATIVE 5'-3' EXONUCLEASE RV2090 (EC 3.1.11.-).	Q7TXP4	No	intermediary metabolism and respiration							IPR011697,IPR017926	Q7TXP4	A0A1R3Y2F8				Rv2859c		Rv2859c			
NC_002945.3	Mycobrowser_v4	CDS	3105995	3106546	.	-	0	Mb2867c	Mb2867c		conserved protein	Mb2867c, -, len: 183 aa. Equivalent to Rv2842c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, similar to Q9Z5J2|MLCB596.11 HYPOTHETICAL 13.7 KDA PROTEIN from Mycobacterium leprae (122 aa), FASTA scores: opt: 192, E(): 2.1e-12, (50.0% identity in 128 aa overlap) (N-terminus shorter). Also similar in part to several hypothetical proteins e.g. Q9KYR2|SC5H4.27 HYPOTHETICAL 19.8 KDA PROTEIN from Streptomyces coelicolor (177 aa), FASTA scores: opt: 288,E(): 2.1e-12, (37.15% identity in 148 aa overlap); O66619|Y260_AQUAE|AQ_260 HYPOTHETICAL PROTEIN from Aquifex aeolicus (158 aa), FASTA scores: opt: 230, E(): 1.7e-08,(31.35% identity in 153 aa overlap); Q9KU82|VC0641 HYPOTHETICAL PROTEIN from Vibrio cholerae (151 aa), FASTA scores: opt: 198, E(): 2.5e-06, (30.9% identity in 152 aa overlap); etc.	X2BM18,P67215	No	conserved hypotheticals								X2BM18,P67215	P67215				Rv2842c		Rv2842c			
NC_002945.3	Mycobrowser_v4	CDS	3106741	3107286	.	+	0	Mb2868	Mb2868		PROBABLE CONSERVED TRANSMEMBRANE ALANINE RICH PROTEIN	Mb2868, -, len: 181 aa. Equivalent to Rv2843, len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Probable conserved transmembrane ala-rich protein, equivalent to Q9Z5J3|ML1560|MLCB596.10c HYPOTHETICAL 17.5 KDA PROTEIN from Mycobacterium leprae (178 aa), FASTA scores: opt: 707, E(): 1.4e-32, (70.25% identity in 168 aa overlap).	Q7TXQ7	No	cell wall and cell processes							IPR006311	Q7TXQ7	A0A1R3Y2S8				Rv2843		Rv2843			
NC_002945.3	Mycobrowser_v4	CDS	3107283	3107771	.	+	0	Mb2869	Mb2869		conserved alanine rich protein	Mb2869, -, len: 162 aa. Equivalent to Rv2844, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q9Z5J4|ML1561|MLCB596.09c HYPOTHETICAL 17.5 KDA PROTEIN from Mycobacterium leprae (165 aa), FASTA scores: opt: 771, E(): 4.9e-46, (71.5% identity in 165 aa overlap). Also similar to Q9KYR4|SC5H4.25c HYPOTHETICAL 16.8 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 242, E(): 1.6e-09, (38.9% identity in 144 aa overlap).	Q7TXQ6	No	conserved hypotheticals							IPR009078,IPR012347	Q7TXQ6	A0A1R3Y2C8				Rv2844		Rv2844			
NC_002945.3	Mycobrowser_v4	CDS	3342634	3343374	.	-	0	Mb3053c	Mb3053c		gcn5-related n-acetyltransferase	Mb3053c, -, len: 246 aa. Equivalent to Rv3027c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Conserved hypothetical protein, similar, but shorter 30 aa in N-terminus, to others e.g. Q9RCY9|SCM10.09c from Streptomyces coelicolor (256 aa), FASTA scores: opt: 498,E(): 7.8e-24, (47.7% identity in 237 aa overlap); BAB50158|MLR3216 from Rhizobium loti (291 aa), FASTA scores: opt: 359, E(): 3.7e-15, (33.35% identity in 246 aa overlap); etc. Equivalent to AAK47441 from Mycobacterium tuberculosis strain CDC1551 (281 aa) but shorter 35 aa.	Q7TXF2	No	intermediary metabolism and respiration							IPR016181	Q7TXF2	A0A1R3Y325				Rv3027c		Rv3027c			
NC_002945.3	Mycobrowser_v4	CDS	3114681	3116570	.	-	0	Mb2875c	Mb2875c		POSSIBLE MAGNESIUM CHELATASE	Mb2875c, -, len: 629 aa. Equivalent to Rv2850c,len: 629 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 629 aa overlap). Possible magnesium-chelatase (EC 4.99.1.-), highly similar (but with gaps) to magnesium-chelatases from notably photosynthetic organisms involved in chlorophyll biosynthesis e.g. Q9RJ18|SCI8.35c PUTATIVE CHELATASE from Streptomyces coelicolor (672 aa), FASTA scores: opt: 1941,E(): 2.1e-85, (54.65% identity in 675 aa overlap); Q9HZQ5|PA2942 PROBABLE MAGNESIUM CHELATASE from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 991,E(): 2.7e-40, (49.45% identity in 368 aa overlap); O33549|BCHI MG PROTOPORPHYRIN IX CHELATASE SUBUNIT from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa), FASTA scores: opt: 833, E(): 9.4e-33, (50.65% identity in 318 aa overlap); O30819|BCHI_RHOSH MAGNESIUM-CHELATASE 38 KDA SUBUNIT from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa), FASTA scores: opt: 828, E(): 1.6e-32, (50.3% identity in 318 aa overlap); etc. Equivalent to AAK47242 from Mycobacterium tuberculosis strain CDC1551 (610 aa) but longer 19 aa. COULB BELONG TO THE MG-CHELATASE SUBUNITS D/I FAMILY.	Q7TXQ1	No	intermediary metabolism and respiration							IPR002035,IPR003593,IPR011704,IPR027417	Q7TXQ1	A0A1R3Y4C6				Rv2850c		Rv2850c			
NC_002945.3	Mycobrowser_v4	CDS	3116567	3117037	.	-	0	Mb2876c	Mb2876c		gcn5-related n-acetyltransferase	Mb2876c, -, len: 156 aa. Equivalent to Rv2851c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Conserved hypothetical protein, similar to various bacterial proteins e.g. Q9KP14|VC2565 ELAA PROTEIN from Vibrio cholerae (149 aa), FASTA scores: opt: 360, E(): 1e-18,(46.05% identity in 139 aa overlap); Q9I717|PA0115 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (150 aa),FASTA scores: opt: 341, E(): 2.4e-17, (43.65% identity in 142 aa overlap); Q9K8M4|BH2982 HYPOTHETICAL PROTEIN from Bacillus halodurans (155 aa), FASTA scores: opt: 320, E(): 8e-16, (40.85% identity in 142 aa overlap); P52077|ELAA_ECOLI|B2267 PROTEIN ELAA from Escherichia coli strain K12 (153 aa), FASTA scores: opt: 269, E(): 3.8e-12,(35.7% identity in 140 aa overlap); etc.	X2BLR6,P67105	No	intermediary metabolism and respiration								X2BLR6,P67105	P67105				Rv2851c		Rv2851c			
NC_002945.3	Mycobrowser_v4	CDS	3125099	3125875	.	-	0	Mb2882c	Mb2882c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb2882c, -, len: 258 aa. Equivalent to Rv2857c,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. O88068|SCI35.33c PROBABLE DEHYDROGENASE (SDR FAMILY) from Streptomyces coelicolor (260 aa), FASTA scores: opt: 1208, E(): 2e-68, (72.35% identity in 253 aa overlap); Q9I376|PA1649 from Pseudomonas aeruginosa PROBABLE SHORT-CHAIN DEHYDROGENASE (253 aa), FASTA scores: opt: 569, E(): 2.1e-28, (39.2% identity in 255 aa overlap); Q9EX74|MLHA SDR-LIKE ENZYME from Rhodococcus erythropolis (246 aa), FASTA scores: opt: 567, E(): 2.8e-28, (41.15% identity in 248 aa overlap); etc. Also similar to many Mycobacterium tuberculosis dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c PUTATIVE OXIDOREDUCTASE (260 aa), FASTA score: (38.3% identity in 248 aa overlap). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TXP6	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040	Q7TXP6	A0A1R3Y2E1				Rv2857c		Rv2857c			
NC_002945.3	Mycobrowser_v4	CDS	3120668	3121708	.	+	0	Mb2879	Mb2879		unknown protein	Mb2879, -, len: 346 aa. Equivalent to Rv2854, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Hypothetical unknown protein, showing similarity with Q9CD03|ML2603 HYPOTHETICAL PROTEIN from Mycobacterium leprae (279 aa),FASTA scores: opt: 154, E(): 0.0083, (33.35% identity in 87 aa overlap).	Q7TXP9	No	conserved hypotheticals								Q7TXP9	A0A1R3Y2E0				Rv2854		Rv2854			
NC_002945.3	Mycobrowser_v4	CDS	3152947	3153366	.	+	0	Mb2911	Mb2911		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb2911, -, len: 139 aa. Equivalent to Rv2887, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable transcriptional regulatory protein, highly similar to Q9EX59|SC1A4.04 PUTATIVE MARR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (151 aa), FASTA scores: opt: 354, E(): 6.6e-16, (42.95% identity in 135 aa overlap); and similar to others e.g. AAF97817|SLYA TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli strain EPEC 2348/69 (146 aa), FASTA scores: opt: 181, E(): 0.0001, (27.25% identity in 132 aa overlap); P55740|SLYA_ECOLI|AAG56631|B1642|Z2657|ECS2351 TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli strains K12 and O157:H7 (146 aa), FASTA scores: opt: 177,E(): 0.00018, (27.25% identity in 132 aa overlap) ; etc. Contains probable helix-turn-helix motif at aa 50-71 (Score 1182, +3.21 SD).	X2BM43,P67748	No	regulatory proteins								X2BM43,P67748	P67748				Rv2887		Rv2887			
NC_002945.3	Mycobrowser_v4	CDS	3164458	3164844	.	-	0	Mb2922c	Mb2922c		CONSERVED HYPOTHETICAL PROTEIN	Mb2922c, -, len: 128 aa. Equivalent to Rv2898c,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Conserved hypothetical protein, highly similar to O33024|YS98_MYCLE|ML1607|MLCB250.49 HYPOTHETICAL 11.0 KDA PROTEIN from Mycobacterium leprae (96 aa), FASTA scores: opt: 318, E(): 2.3e-16, (58.35% identity in 96 aa overlap). Also similar to other hypothetical proteins e.g. O69890|YE19_STRCO|SC2E1.19 from Streptomyces coelicolor (130 aa), FASTA scores: opt: 253, E(): 1.7e-11, (39.65% identity in 121 aa overlap); Q9HVZ1|PA4424 from Pseudomonas aeruginosa (125 aa), FASTA scores: opt: 234,E(): 4.2e-10, (40.85% identity in 115 aa overlap); O86871 from Streptomyces lividans (85 aa), FASTA scores: opt: 224, E(): 1.8e-09, (46.45% identity in 84 aa overlap); etc. Equivalent to AAK47292 from Mycobacterium tuberculosis strain CDC1551 (141 aa) but shorter 13 aa.	X2BLY4,P67231	No	conserved hypotheticals								X2BLY4,P67231	P67231				Rv2898c		Rv2898c			
NC_002945.3	Mycobrowser_v4	CDS	3131970	3133781	.	-	0	Mb2889c	Mb2889c		POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	Mb2889c, -, len: 603 aa. Equivalent to Rv2864c,len: 603 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 603 aa overlap). Possible penicillin-binding lipoprotein, probably located in periplasm, equivalent to Q9CBU6|ML1577 PROBABLE PENICILLIN BINDING PROTEIN from Mycobacterium leprae (608 aa), FASTA scores: opt: 3352, E(): 2.1e-193, (81.5% identity in 606 aa overlap). Also shows some similarity to others e.g. P72405|PCBR from Streptomyces clavuligerus (551 aa), FASTA scores: opt: 543, E(): 6.1e-25, (28.4% identity in 567 aa overlap); Q9F2L0|SCH63.18c from Streptomyces coelicolor (546 aa), FASTA scores: opt: 519, E(): 1.7e-23, (29.3% identity in 577 aa overlap); Q9RKD1|SCE87.07 from Streptomyces coelicolor (541 aa), FASTA scores: opt: 472,E(): 1.1e-20, (34.3% identity in 318 aa overlap); etc. Equivalent to AAK47258 from Mycobacterium tuberculosis strain CDC1551 (618 aa) but shorter 15 aa. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TXP0	No	cell wall and cell processes							IPR001460,IPR007887,IPR012338	Q7TXP0	A0A1R3Y2F2				Rv2864c		Rv2864c			
NC_002945.3	Mycobrowser_v4	CDS	3130575	3131159	.	-	0	Mb2887c	Mb2887c		CONSERVED HYPOTHETICAL PROTEIN	Mb2887c, -, len: 194 aa. Equivalent to Rv2862c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 194 aa overlap). Conserved hypothetical protein, showing some similarity with others e.g. Q9X8X5|SCH35.31c HYPOTHETICAL 19.6 KDA PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 266,E(): 2.2e-11, (34.65% identity in 179 aa overlap); Q9Z5H1|ML0169|MLCB373.19 HYPOTHETICAL 22.1 KDA PROTEIN from Mycobacterium leprae (200 aa), FASTA scores: opt: 195, E(): 2.3e-06, (30.15% identity in 189 aa overlap); etc. Also some similarity to P71544|Y966_MYCTU|Rv0966c|MT0994|MTCY10D7.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (230 aa), FASTA scores: opt: 209, E(): 2.6e-07, (31.5% identity in 184 aa overlap).	Q7TXP2	No	conserved hypotheticals							IPR012551	Q7TXP2	A0A1R3Y2K8				Rv2862c		Rv2862c			
NC_002945.3	Mycobrowser_v4	CDS	3144179	3144493	.	+	0	Mb2901	Mb2901		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb2901, -, len: 104 aa. Equivalent to Rv2876, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 104 aa overlap). Possible conserved transmembrane protein, equivalent (but longer 16 aa) to Q9CBU2|ML1584 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (84 aa), FASTA scores: opt: 444, E(): 8.3e-26, (73.85% identity in 88 aa overlap).	Q7TXN4	No	cell wall and cell processes							IPR024341	Q7TXN4	A0A1R3Y2F6				Rv2876		Rv2876			
NC_002945.3	Mycobrowser_v4	CDS	3144524	3145387	.	-	0	Mb2902c	Mb2902c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2902c, -, len: 287 aa. Equivalent to Rv2877c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). Probable conserved integral membrane protein, Mer family possibly involved in transport of mercury, similar to others, and to the fourth protein of the mercury resistance operon of Streptomyces sp (or other organisms), and to putative cytochrome-c biogenesis proteins e.g. Q9XBD1|CZA382.20C PUTATIVE INTEGRAL MEMBRANE TRANSPORTER from Amycolatopsis orientalis (298 aa), FASTA scores: opt: 913, E(): 7.6e-46,(51.55% identity in 293 aa overlap); P30344|MER4_STRLI MERCURY RESISTANCE PROBABLE HG TRANSPORT PROTEIN from Streptomyces lividans (319 aa), FASTA scores: opt: 427,E(): 1.2e-17, (32.85% identity in 289 aa overlap); Q9M5P3 PUTATIVE CYTOCHROME C BIOGENESIS PROTEIN PRECURSOR from Arabidopsis thaliana (Mouse-ear cress) (354 aa), FASTA scores: opt: 229, E(): 4e-06, (29.85% identity in 221 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Note that previously known as merT.	Q7TXN3	No	cell wall and cell processes							IPR003834	Q7TXN3	A0A1R3Y2H3				Rv2877c		Rv2877c			
NC_002945.3	Mycobrowser_v4	CDS	3146099	3147193	.	-	0	Mb2904c	Mb2904c		CONSERVED HYPOTHETICAL PROTEIN	Mb2904c, -, len: 364 aa. Equivalent to 5' end of Rv2880c and 3' end of Rv2879c, len: 275 aa and 189 aa,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 177 aa overlap and 100.0% identity in 188 aa overlap). Rv2880c: Conserved hypothetical protein, highly similar in N-terminus to others e.g. O86754|SC6A9.22c HYPOTHETICAL 40.4 KDA PROTEIN from Streptomyces coelicolor (368 aa), FASTA scores: opt: 663, E(): 2.6e-33, (52.6% identity in 213 aa overlap); Q55880|Y098_SYNY3|SLL0098 HYPOTHETICAL 38.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (350 aa), FASTA scores: opt: 362, E(): 7.3e-15, (38.9% identity in 162 aa overlap); O66732|AQ_416 HYPOTHETICAL 40.2 KDA PROTEIN from Aquifex aeolicus (348 aa), FASTA scores: opt: 321, E(): 2.4e-12, (39.75% identity in 146 aa overlap); etc. Appears to be a frame shift with respect to preceding ORF but we can detect no error in the cosmid sequence to account for this. Rv2879c: Conserved hypothetical protein, similar to others e.g. C-terminus of Q9RVT6|DR0936 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (346 aa), FASTA scores: opt: 505, E(): 1e-26, (46.5% identity in 185 aa overlap); O34617|YLON_BACSU HYPOTHETICAL 41.6 KDA PROTEIN from Bacillus subtilis (363 aa), FASTA scores: opt: 459, E(): 1.2e-24, (40.5% identity in 185 aa overlap); YFGB_ECOLI|P36979 hypothetical 43.1 kd protein from Escherichia coli (384 aa), FASTA scores, opt: 410, E(): 2.8e-21, (41.7% identity in 187 aa overlap); etc. Appears to be a frame shift with respect to following ORF but we can detect no error in the cosmid sequence to account for this. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2880c and Rv2879c exist as 2 genes. In Mycobacterium bovis, a single base deletion (g-*) leads to a single product.	X2BMN8,P0A645	No									X2BMN8,P0A645	P0A645									
NC_002945.3	Mycobrowser_v4	CDS	3156782	3157531	.	+	0	Mb2915	Mb2915		CONSERVED HYPOTHETICAL PROTEIN	Mb2915, -, len: 249 aa. Equivalent to Rv2891, len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Conserved hypothetical protein, similar in N-terminus to O69910|SC2E1.40c HYPOTHETICAL 22.8 KDA PROTEIN from Streptomyces coelicolor (226 aa), FASTA scores: opt: 315,E(): 3.4e-11, (40.7% identity in 145 aa overlap). C-terminus overlaps neigbouring ORF.	X2BLU3	No	conserved hypotheticals								X2BLU3	P65048				Rv2891		Rv2891			
NC_002945.3	Mycobrowser_v4	CDS	3149908	3150666	.	+	0	Mb2908	Mb2908		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb2908, -, len: 252 aa. Equivalent to Rv2884, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable transcriptional regulatory protein, highly similar to others e.g. Q05943|GLNR_STRCO|SCD84.26c TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (267 aa),FASTA scores: opt: 609, E(): 2.7e-34, (46.4% identity in 224 aa overlap); Q55733|SLL0396 REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM from Synechocystis sp. strain PCC 6803 (224 aa), FASTA scores: opt: 330, E(): 3e-15,(31.8% identity in 217 aa overlap); Q9A4S3|CC2757 DNA-BINDING RESPONSE REGULATOR from Caulobacter crescentus (223 aa), FASTA scores: opt: 311, E(): 6e-14, (30.3% identity in 221 aa overlap); etc. Also highly similar to O53830|Rv0818|MTV043.10 PUTATIVE REGULATORY PROTEIN from Mycobacterium tuberculosis (255 aa), FASTA scores: opt: 665, E(): 3.8e-38, (47.6% identity in 227 aa overlap). THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS.	Q7TXN2	No	regulatory proteins							IPR001867,IPR011991,IPR016032	Q7TXN2	A0A1R3Y2G7				Rv2884		Rv2884			
NC_002945.3	Mycobrowser_v4	CDS	3150745	3152064	.	-	0	Mb2909c	Mb2909c		probable transposase	Mb2909c, -, len: 439 aa. Equivalent to Rv2885c,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 437 aa overlap). Putative transposase for IS1539. Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (439 aa versus 460 aa).	Q7TXN1	No	insertion seqs and phages							IPR001959,IPR010095,IPR021027	Q7TXN1	A0A1R3Y2H2				Rv2885c		Rv2885c			
NC_002945.3	Mycobrowser_v4	CDS	3158936	3159913	.	+	0	Mb2917	Mb2917		POSSIBLE OXIDOREDUCTASE	Mb2917, -, len: 325 aa. Equivalent to Rv2893, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 325 aa overlap). Possible oxidoreductase (EC 1.-.-.-), showing similarity with various proteins and/or oxidoreductases e.g. Q9AE05|RIF11 eleventh protein in the rif biosynthetic gene cluster from Amycolatopsis mediterranei (Nocardia mediterranei) (294 aa), FASTA scores: opt: 270, E(): 4.8e-10, (34.5% identity in 313 aa overlap); O52567 REDUCTASE from Amycolatopsis mediterranei (Nocardia mediterranei) (153 aa), FASTA scores: opt: 251, E(): 5e-09, (42.4% identity in 125 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 249, E(): 1.2e-08, (29.7% identity in 283 aa overlap); etc. Also some similarity with others proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. P71844|Rv0791c|MTCY369.35c PUTATIVE OXIDOREDUCTASE (347 aa), FASTA scores: opt: 264, E(): 1.3e-09, (29.05% identity in 272 aa overlap); and P96809|Rv0132|MTCI5.06c PUTATIVE OXIDOREDUCTASE (360 aa), FASTA scores: opt: 260,E(): 2.4e-09, (33.05% identity in 239 aa overlap).	Q7TXM9	No	intermediary metabolism and respiration							IPR011251,IPR019923	Q7TXM9	A0A1R3Y2X5				Rv2893		Rv2893			
NC_002945.3	Mycobrowser_v4	CDS	3161781	3162950	.	-	0	Mb2920c	Mb2920c		CONSERVED HYPOTHETICAL PROTEIN	Mb2920c, -, len: 389 aa. Equivalent to Rv2896c,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 389 aa overlap). Conserved hypothetical protein, similar to others proteins e.g. Q9ZJ08|FIR2 from Rhodococcus fascians (293 aa), FASTA scores: opt: 663,E(): 3.3e-32, (43.7% identity in 286 aa overlap); O69892|SC2E1.21 HYPOTHETICAL 37.9 KDA PROTEIN from Streptomyces coelicolor (382 aa), FASTA scores: opt: 600,E(): 2.2e-28, (46.45% identity in 267 aa overlap); Q9JWZ4|DPRA|NMA0158 DPRA HOMOLOG from Neisseria meningitidis (serogroup A) (395 aa), FASTA scores: opt: 495, E(): 4.1e-22, (34.6% identity in 347 aa overlap); etc.	Q7TXM8	No	conserved hypotheticals							IPR003488	Q7TXM8	A0A1R3Y2I9				Rv2896c		Rv2896c			
NC_002945.3	Mycobrowser_v4	CDS	3162947	3164458	.	-	0	Mb2921c	Mb2921c		CONSERVED HYPOTHETICAL PROTEIN	Mb2921c, -, len: 503 aa. Equivalent to Rv2897c,len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Conserved hypothetical protein, possibly Mg-chelatase, highly similar to hypothetical proteins and chelatases e.g. Q9RTV0|DR1656 MG(2+) CHELATASE FAMILY PROTEIN from Deinococcus radiodurans (519 aa), FASTA scores: opt: 1333,E(): 3.6e-68, (46.55% identity in 505 aa overlap);Q55372|SLR0904 HYPOTHETICAL 55.1 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (509 aa), FASTA scores: opt: 1271, E(): 1.2e-64, (42.65% identity in 504 aa overlap); Q9HTR4|PA5290 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (497 aa), FASTA scores: opt: 1248,E(): 2.3e-63, (45.9% identity in 503 aa overlap); Q9K0Z6|COMM|NMB0405 COMPETENCE PROTEIN (MG-CHELATASE) from Neisseria meningitidis (serogroup B), FASTA scores: opt: 1229, E(): 2.8e-62, (43.2% identity in 509 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	X2BM50,P68908	No	conserved hypotheticals								X2BM50,P68908	P68908				Rv2897c		Rv2897c			
NC_002945.3	Mycobrowser_v4	CDS	3351939	3353021	.	+	0	Mb3061	Mb3061		conserved protein	Mb3061, -, len: 360 aa. Equivalent to Rv3035, len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 360 aa overlap). Conserved hypothetical protein, equivalent to Q9CBR0|ML1720 HYPOTHETICAL PROTEIN from Mycobacterium leprae (364 aa),FASTA scores: opt: 1963, E(): 1.4e-108, (75.8% identity in 363 aa overlap).	Q7TXE5	No	conserved hypotheticals							IPR011047,IPR018391,IPR027295	Q7TXE5	A0A1R3Y3P0				Rv3035		Rv3035			
NC_002945.3	Mycobrowser_v4	CDS	3176379	3178214	.	-	0	Mb2937c	Mb2937c		possible d-amino acid aminohydrolase (d-amino acid hydrolase)	Mb2937c, -, len: 611 aa. Equivalent to Rv2913c,len: 611 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 611 aa overlap). Possible D-amino acid aminohydrolase (EC 3.5.1.-), similar (principally in N-terminus) to D-amino acid aminohydrolases e.g. Q9V2D3|NDAD|PAB0090 D-AMINOACYLASE (ASPARTATE, GLUTAMATE ETC) from Pyrococcus abyssi (526 aa), FASTA scores: opt: 336, E(): 2.2e-13, (27.55% identity in 581 aa overlap); P94212|NDDD_ALCXX N-ACYL-D-ASPARTATE DEACYLASE (EC 3.5.1.83) (N-ACYL-D-ASPARTATE AMIDOHYDROLASE) from Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans) (498 aa), FASTA scores: opt: 221, E(): 3.4e-06, (25.95% identity in 532 aa overlap); Q9AGH8 D-AMINOACYLASE (EC 3.5.1.81) from Alcaligenes faecalis (484 aa), FASTA scores: opt: 218, E(): 5.1e-06, (28.35% identity in 434 aa overlap); etc.	X2BLZ8,P65531	No	intermediary metabolism and respiration								X2BLZ8,P65531	P65531				Rv2913c		Rv2913c			
NC_002945.3	Mycobrowser_v4	CDS	3620343	3620774	.	+	0	Mb3312	Mb3312		CONSERVED HYPOTHETICAL PROTEIN	Mb3312, -, len: 143 aa. Equivalent to Rv3284, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein, with similarity to other bacterial hypothetical proteins e.g. Q9RXU0|DR0216 from Deinococcus radiodurans (147 aa), FASTA scores: opt: 425, E(): 9.1e-21, (46.55% identity in 146 aa overlap); BAB37094|ECS3671 from Escherichia coli strain O157:H7 (147 aa), FASTA scores: opt: 187, E(): 2.2e-05, (29.5% identity in 139 aa overlap); AAG57925|YGDK from Escherichia coli strain O157:H7 EDL933 (147 aa), FASTA scores: opt: 187,E(): 2.2e-05, (32.05% identity in 139 aa overlap); etc.	X2BN24	No	conserved hypotheticals								X2BN24	P67124				Rv3284		Rv3284			
NC_002945.3	Mycobrowser_v4	CDS	3199543	3199854	.	+	0	Mb2954	Mb2954		HYPOTHETICAL PROTEIN	Mb2954, -, len: 103 aa. Equivalent to Rv2929, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Hypothetical unknown protein; unlikely ORF but some weak similarity to C-terminal half of P18319|UREG_KLEAE urease accessory protein from klebsiella aerogenes (205 aa), FASTA scores: opt: 99, E(): 1.1, (38.6% identity in 57 aa overlap).	X2BMU1	No	conserved hypotheticals								X2BMU1	P65062				Rv2929		Rv2929			
NC_002945.3	Mycobrowser_v4	CDS	3173421	3173663	.	-	0	Mb2932c	Mb2932c		CONSERVED HYPOTHETICAL PROTEIN	Mb2932c, -, len: 80 aa. Equivalent to Rv2908c, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Conserved hypothetical protein, equivalent to O33015|YT08_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 492, E(): 3.1e-29, (93.75% identity in 80 aa overlap). Also highly similar to others e.g. O69880|YE09_STRCO from Streptomyces coelicolor (79 aa), FASTA scores: opt: 356, E(): 3e-19,(71.6% identity in 74 aa overlap); Q9KA12|BH2482 PROTEIN from Bacillus halodurans (76 aa), FASTA scores: opt: 220,E(): 2.9e-09, (48.6% identity in 72 aa overlap); O31738|YLQC_BACSU HYPOTHETICAL 9.1 KDA PROTEIN from Bacillus subtilis (81 aa), FASTA scores: opt: 172, E(): 1e-05, (39.2% identity in 74 aa overlap); etc. BELONGS TO THE UPF0109 FAMILY.	X2BLZ3,P67237	No	conserved hypotheticals								X2BLZ3,P67237	P67237				Rv2908c		Rv2908c			
NC_002945.3	Mycobrowser_v4	CDS	3174343	3174786	.	-	0	Mb2934c	Mb2934c		CONSERVED HYPOTHETICAL PROTEIN	Mb2934c, -, len: 147 aa. Equivalent to Rv2910c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein, showing some similarity with hypothetical proteins from other organisms e.g. Q9JN76|MMYY HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 164,E(): 0.00026, (35.05% identity in 129 aa overlap); etc. Also some similarity with protein from Mycobacterium tuberculosis e.g. O07237|Rv0310c|MTCY63.15c (163 aa),FASTA scores: opt: 165, E(): 0.00023, (26.3% identity in 137 aa overlap); P96815|Rv0138|MTCI5.12 (167 aa), FASTA scores: opt: 132, E(): 0.048, (30.25% identity in 109 aa overlap); etc.	X2BMR9	No	conserved hypotheticals								X2BMR9	P65054				Rv2910c		Rv2910c			
NC_002945.3	Mycobrowser_v4	CDS	3175790	3176377	.	-	0	Mb2936c	Mb2936c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb2936c, -, len: 195 aa. Equivalent to Rv2912c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). Probable transcription regulatory protein, tetR family, showing similarity with others e.g. Q9K3V9|SCD10.17 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (202 aa), FASTA scores: opt: 185, E(): 4.4e-05, (31.15% identity in 167 aa overlap); Q9KFQ0 TETR-FAMILY from Bacillus halodurans (185 aa), FASTA scores: opt: 164, E(): 0.001, (35.6% identity in 73 aa overlap); P17446|BETI_ECOLI|BETI|B0313 regulatory protein from Escherichia coli strain K12 (195 aa), FASTA scores: opt: 126, E(): 0.024, (24.5% identity in 196 aa overlap); etc. Contains possible helix-turn-helix motif at aa 33-54 (+2.71 SD). POSSIBLY BELONGS TO THE TETR/ACRR FAMILY.	X2BM59,P67441	No	regulatory proteins								X2BM59,P67441	P67441				Rv2912c		Rv2912c			
NC_002945.3	Mycobrowser_v4	CDS	3415663	3417354	.	+	0	Mb3118	Mb3118		conserved protein	Mb3118, -, len: 563 aa. Equivalent to Rv3091, len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 563 aa overlap). Hypothetical protein,similar in part to O60859 NEUROPATHY TARGET ESTERASE from Homo sapiens (Human) (1327 aa), FASTA scores: opt: 177,E(): 0.0062, (30.65% identity in 173 aa overlap); and Q9I385|PA1640 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (345 aa), FASTA scores: opt: 152, E(): 0.069,(27.8% identity in 180 aa overlap).	Q7TX99	No	conserved hypotheticals							IPR002641,IPR016035	Q7TX99	A0A1R3Y338				Rv3091		Rv3091			
NC_002945.3	Mycobrowser_v4	CDS	3180084	3181196	.	-	0	Mb2939c	Mb2939c		conserved protein	Mb2939c, -, len: 370 aa. Equivalent to Rv2915c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 370 aa overlap). Conserved hypothetical protein, posssibly XAA-PRO dipeptidase (prolidase) (EC 3.4.13.9), highly similar to CAC38796|SCI39.08c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (363 aa), FASTA scores: opt: 1341,E(): 5.5e-76, (56.65% identity in 362 aa overlap); and similar to prolidases (XAA-PRO dipeptidase) e.g. Q9ABC9|CC0300 PUTATIVE XAA-PRO DIPEPTIDASE from Caulobacter crescentus (428 aa), FASTA scores: opt: 327,E(): 7.4e-13, (30.2% identity in 374 aa overlap); Q97XD4 PROLIDASE from Sulfolobus solfataricus (396 aa), FASTA scores: opt: 271, E(): 2.1e-09, (30.5% identity in 354 aa overlap); Q9WX55 PROLIDASE from Microbacterium esteraromaticum (393 aa), FASTA scores: opt: 256, E(): 1.8e-08, (27.95% identity in 365 aa overlap); etc. Also similar to O53619|Rv0074|MTV030.18 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (411 aa), FASTA scores: opt: 243, E(): 1.2e-07, (27.5% identity in 389 aa overlap).	X2BMS4	No	conserved hypotheticals								X2BMS4	P68916				Rv2915c		Rv2915c			
NC_002945.3	Mycobrowser_v4	CDS	3182879	3184759	.	+	0	Mb2941	Mb2941		CONSERVED HYPOTHETICAL ALANINE AND ARGININE RICH PROTEIN	Mb2941, -, len: 626 aa. Equivalent to Rv2917, len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 626 aa overlap). Conserved hypothetical ala-, arg-rich protein, highly similar (but longer 34 aa) to O33011|ML1624|MLCB250.18C HYPOTHETICAL 65.2 KDA PROTEIN from Mycobacterium leprae (596 aa), FASTA scores: opt: 3117, E(): 9e-183, (79.8% identity in 584 aa overlap). Also highly similar to Q9S2E8|SCE19A.36C HYPOTHETICAL 66.2 KDA PROTEIN from Streptomyces coelicolor (598 aa), FASTA scores: opt: 1921, E(): 1.1e-109, (56.08% identity in 567 aa overlap); and Q9S3Y6|SDRA SDRA PROTEIN from Streptomyces coelicolor (597 aa), FASTA scores: opt: 1896,E(): 3.6e-108, (55.75% identity in 567 aa overlap). And shows some similarity with others proteins from other organisms. Equivalent to AAK47311 putative RNA helicase from Mycobacterium tuberculosis strain CDC1551 (602 aa) but longer 24 aa. Contains PS00017 ATP/GTP-binding site motif (P-loop).	Q7TXM4	No	conserved hypotheticals							IPR001650,IPR003593,IPR006935,IPR014001,IPR027417	Q7TXM4	A0A1R3Y2J6				Rv2917		Rv2917			
NC_002945.3	Mycobrowser_v4	CDS	3194714	3195127	.	-	0	Mb2948c	Mb2948c		conserved protein	Mb2948c, -, len: 137 aa. Equivalent to Rv2923c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein, showing similarity with other hypothetical proteins e.g. P24246|YHFA_ECOLI|B3356|Z4717|ECS4207 from Escherichia coli strains K12 and O157:H7 (134 aa), FASTA scores: opt: 110, E(): 1.9, (25.9% identity in 135 aa overlap); etc.	X2BMH5,P65056	No	conserved hypotheticals								X2BMH5,P65056	P65056				Rv2923c		Rv2923c			
NC_002945.3	Mycobrowser_v4	CDS	3197121	3197744	.	-	0	Mb2951c	Mb2951c		conserved protein	Mb2951c, -, len: 207 aa. Equivalent to Rv2926c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Conserved hypothetical protein, equivalent to O69468|ML1660|MLCB1243.14 HYPOTHETICAL 23.5 KDA PROTEIN from Mycobacterium leprae (217 aa), FASTA scores: opt: 866, E(): 1.4e-48, (67.2% identity in 192 aa overlap). Also similar in part to other hypothetical proteins e.g. Q9WXZ8 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (182 aa), FASTA scores: opt: 254, E(): 3.4e-09,(31.45% identity in 143 aa overlap); Q9ZBQ9|SC7A1.14 HYPOTHETICAL 23.5 KDA PROTEIN from Streptomyces coelicolor (217 aa), FASTA scores: opt: 244, E(): 1.7e-08, (45.5% identity in 189 aa overlap); O65982 HYPOTHETICAL 26.2 KDA PROTEIN from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (228 aa),FASTA scores: opt: 220, E(): 6.1e-07, (32.45% identity in 148 aa overlap); etc. Equivalent to AAK47323 from Mycobacterium tuberculosis strain CDC1551 (195 aa) but longer 12 aa.	X2BM68	No	conserved hypotheticals								X2BM68	P65058				Rv2926c		Rv2926c			
NC_002945.3	Mycobrowser_v4	CDS	3197795	3198532	.	-	0	Mb2952c	Mb2952c		CONSERVED HYPOTHETICAL PROTEIN	Mb2952c, -, len: 245 aa. Equivalent to Rv2927c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Conserved hypothetical protein, equivalent to Q9CBS6|ML1661|MLCB1243.13 (alias O69467) HYPOTHETICAL PROTEIN from Mycobacterium leprae (247 aa), FASTA scores: opt: 1440, E(): 4.9e-76, (90.6% identity in 245 aa overlap). Also similar to many hypothetical proteins from other organisms e.g. Q9ZBR0|SC7A1.13 HYPOTHETICAL 41.0 KDA PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 266, E(): 3.4e-08, (29.9% identity in 234 aa overlap); etc. Also some similarity with P46815|AG84_MYCLE|ML0922 ANTIGEN 84 from Mycobacterium leprae (266 aa), FASTA scores: opt: 193, E(): 0.00043,(28.7% identity in 136 aa overlap) (see citation below); and P46816|AG84_MYCTU|WAG31|Rv2145c|MT2204|MTCY270.23 ANTIGEN 84 from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 178, E(): 0.0031, (34.35% identity in 131 aa overlap) (see citation below). Contains potential coiled-coil region.	X2BM16	No	conserved hypotheticals								X2BM16	P65060				Rv2927c		Rv2927c			
NC_002945.3	Mycobrowser_v4	CDS	3734618	3735052	.	+	0	Mb3404	Mb3404		conserved protein	Mb3404, -, len: 144 aa. Equivalent to Rv3369, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Conserved hypothetical protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c HYPOTHETICAL 14.7 KDA PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: opt: 174,E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa), FASTA scores: opt: 125, E(): 0.13,(31.05% identity in 116 aa overlap).	Q7TWM0	No	conserved hypotheticals							IPR011576,IPR012349,IPR019966	Q7TWM0	A0A1R3Y404				Rv3369		Rv3369			
NC_002945.3	Mycobrowser_v4	CDS	3259791	3260936	.	-	0	Mb2975c	Mb2975c		POSSIBLE OXIDOREDUCTASE	Mb2975c, -, len: 381 aa. Equivalent to Rv2951c,len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 381 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to Q9CD85 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (382 aa), FASTA scores: opt: 2225, E(): 7.6e-134, (84.8% identity in 382 aa overlap); and similar to O30260 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (363 aa), FASTA scores: opt: 652, E(): 6.1e-34, (32.55% identity in 344 aa overlap). Also similar to various oxidoreductases e.g. O29071|AF1196 N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Archaeoglobus fulgidus (348 aa), FASTA scores: opt: 381, E(): 9.7e-17, (27.7% identity in 354 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 372, E(): 3.5e-16, (30.85% identity in 295 aa overlap); Q9UXP0 PUTATIVE F420-DEPENDENT N5,N10-METHYLENE-TETRAHYDROMETHANOPTERIN REDUCTASE from Methanolobus tindarius (326 aa), FASTA scores: opt: 343,E(): 2.4e-14, (27.4% identity in 314 aa overlap); etc.	X2BM02,Q7TXK4	No	intermediary metabolism and respiration								X2BM02,Q7TXK4	Q7TXK4				Rv2951c		Rv2951c			
NC_002945.3	Mycobrowser_v4	CDS	3328430	3329086	.	+	0	Mb3038	Mb3038		conserved protein	Mb3038, -, len: 218 aa. Equivalent to Rv3013, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Conserved hypothetical protein, equivalent to O33103|MLCB637_11c HYPOTHETICAL 24.4 KDA PROTEIN from Mycobacterium leprae (230 aa), FASTA scores: opt: 1188, E(): 2.6e-67, (83.95% identity in 218 aa overlap). Equivalent to AAK47422 from Mycobacterium tuberculosis strain CDC1551 (240 aa) but shorter 22 aa.	Q7TXG1	No	conserved hypotheticals							IPR002912	Q7TXG1	A0A1R3Y2U5				Rv3013		Rv3013			
NC_002945.3	Mycobrowser_v4	CDS	3261129	3261941	.	+	0	Mb2976	Mb2976		POSSIBLE METHYLTRANSFERASE (METHYLASE)	Mb2976, -, len: 270 aa. Equivalent to Rv2952, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 270 aa overlap). Probable methyltransferase (EC 2.1.1.-), equivalent to Q9CD86|ML0130 HYPOTHETICAL PROTEIN from Mycobacterium leprae (270 aa), FASTA scores: opt: 1584, E(): 6.1e-99,(83.7% identity in 270 aa overlap). Also highly similar to Q9RMN9|MTF2 PUTATIVE METHYLTRANSFERASE from Mycobacterium smegmatis (274 aa), FASTA scores: opt: 902, E(): 3.8e-53,(56.35% identity in 252 aa overlap). Also similar to other methyltransferases e.g. Q9ADL4|SORM O-METHYLTRANSFERASE from Polyangium cellulosum (346 aa), FASTA scores: opt: 390, E(): 1.1e-18, (36.25% identity in 251 aa overlap); Q54303|RAPM METHYLTRANSFERASE from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 315, E(): 1.1e-13, (40.75% identity in 135 aa overlap); etc. Very similar to C-terminal part of Q50584|Rv1523|MTCY19G5.05c HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium tuberculosis (358 aa), FASTA score: opt: 965, E(): 2.7e-57, (60.3% identity in 247 aa overlap).	X2BMB7,Q7TXK3	No	intermediary metabolism and respiration								X2BMB7,Q7TXK3	Q7TXK3				Rv2952		Rv2952			
NC_002945.3	Mycobrowser_v4	CDS	3423757	3424209	.	-	0	Mb3125c	Mb3125c		HYPOTHETICAL PROTEIN	Mb3125c, -, len: 150 aa. Equivalent to Rv3098c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Hypothetical unknown protein (shorter version of MTCY164.09c).	Q7TX93	No	conserved hypotheticals								Q7TX93	A0A1R3Y353				Rv3098c		Rv3098c			
NC_002945.3	Mycobrowser_v4	CDS	3261967	3263223	.	+	0	Mb2977	Mb2977		enoyl reductase	Mb2977, -, len: 418 aa. Equivalent to Rv2953, len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 418 aa overlap). Conserved hypothetical protein, equivalent to Q9CD87|ML0129 HYPOTHETICAL PROTEIN from Mycobacterium leprae (418 aa),FASTA scores: opt: 2357, E(): 2.7e-143, (86.6% identity in 418 aa overlap). Also highly similar to Q9X7N5|SC5F2A.12c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (396 aa), FASTA scores: opt: 491, E(): 7e-24,(38.35% identity in 417 aa overlap); and similar to other hypothetical proteins e.g. Q9VG81 CG5167 PROTEIN from Drosophila melanogaster (Fruit fly) (431 aa), FASTA scores: opt: 393, E(): 1.4e-17, (26.55% identity in 433 aa overlap); Q9GZE9|F22F7.1 HYPOTHETICAL PROTEIN from Caenorhabditis elegans (426 aa), FASTA scores: opt: 338,E(): 4.6e-14, (27.05% identity in 425 aa overlap); P73855|SLL1601 HYPOTHETICAL 44.8 KDA PROTEIN from Synechocystis sp. (strain PCC 6803) (414 aa), FASTA scores: opt: 565, E(): 1.3e-28, (35.7% identity in 409 aa overlap); etc. Also highly similar to other proteins from Mycobacterium tuberculosis e.g. RV2449C|O53176|MTV008.05C HYPOTHETICAL 44.4 KDA PROTEIN (419 aa), FASTA scores: opt: 1835, E(): 7e-110, (67.55% identity in 419 aa overlap); etc.	X2BM75,Q7TXK2	No	lipid metabolism								X2BM75,Q7TXK2	Q7TXK2				Rv2953		Rv2953			
NC_002945.3	Mycobrowser_v4	CDS	3263354	3264079	.	-	0	Mb2978c	Mb2978c		HYPOTHETICAL PROTEIN	Mb2978c, -, len: 241 aa. Equivalent to Rv2954c,len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Hypothetical unknown protein. Equivalent to AAK47354 from Mycobacterium tuberculosis strain CDC1551 (199 aa) but longer 42 aa.	Q7TXK1	No	conserved hypotheticals								Q7TXK1	A0A1R3Y2Q0				Rv2954c		Rv2954c			
NC_002945.3	Mycobrowser_v4	CDS	3696732	3696989	.	-	0	Mb3378c	Mb3378c		conserved transmembrane protein	Mb3378c, -, len: 85 aa. Equivalent to Rv3346c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, highly similar to mycobacterium hypothetical proteins O50384|Rv3355c|MTV004.12c from strain H37Rv (97 aa), FASTA scores: opt: 413, E(): 4.6e-23, (85.55% identity in 97 aa overlap); O32878|MLCB1779.16c|ML0675 from Mycobacterium leprae (91 aa), FASTA scores: opt: 349,E(): 1.7e-18, (67.35% identity in 95 aa overlap).	Q7TWN8	No	cell wall and cell processes							IPR021385	Q7TWN8	A0A1R3Y3X4				Rv3346c		Rv3346c			
NC_002945.3	Mycobrowser_v4	CDS	3264268	3265233	.	-	0	Mb2979c	Mb2979c		conserved protein	Mb2979c, -, len: 321 aa. Equivalent to Rv2955c,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 321 aa overlap). Conserved hypothetical protein, similar to others e.g. Q98NV5|MLL9724 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (284 aa), FASTA scores: opt: 231, E(): 6.5e-08,(34.6% identity in 182 aa overlap); Q9AGG2|NLPE1 NLPE1 from Rhizobium etli (249 aa), FASTA scores: opt: 212, E(): 1.1e-06, (27.85% identity in 255 aa overlap); Q9KXY2 HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces coelicolor(291 aa), FASTA scores: opt: 211, E(): 1.4e-06,(30.9% identity in 249 aa overlap); etc.	Q7TXK0	No	conserved hypotheticals							IPR006342	Q7TXK0	A0A1R3Y2P3				Rv2955c		Rv2955c			
NC_002945.3	Mycobrowser_v4	CDS	3265356	3266087	.	+	0	Mb2980	Mb2980		conserved protein	Mb2980, -, len: 243 aa. Equivalent to Rv2956, len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 243 aa overlap). Conserved hypothetical protein, highly similar to O86299|GSC GSC PROTEIN from Mycobacterium avium subsp. silvaticum Mycobacterium avium (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap); and O86294|GSC GSC PROTEIN from Mycobacterium paratuberculosis (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap). Also some similarity with other proteins from other organisms e.g. Q9L727 NODULATION PROTEIN NOEI from Rhizobium fredii (Sinorhizobium fredii) (241 aa), FASTA scores: opt: 205, E(): 3.5e-06, (27.25% identity in 198 aa overlap); Q9AGG1|LPEA LPEA PROTEIN from Rhizobium etli (286 aa), FASTA scores: opt: 201, E(): 7.2e-06, (28.85% identity in 208 aa overlap); P74191|SLL1173 HYPOTHETICAL 28.0 KDA PROTEIN Synechocystis sp. (strain PCC 6803) (244 aa), FASTA scores: opt: 274, E(): 1e-10, (30.65% identity in 225 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P71792|RV1513|MTCY277.35 HYPOTHETICAL 26.7 KDA PROTEIN (243 aa), FASTA scores: opt: 1105, E(): 1.7e-65, (70.05% identity in 237 aa overlap); etc.	Q7TXJ9	No	conserved hypotheticals							IPR006342	Q7TXJ9	A0A1R3Y2N6				Rv2956		Rv2956			
NC_002945.3	Mycobrowser_v4	CDS	3266158	3266985	.	+	0	Mb2981	Mb2981		POSSIBLE GLYCOSYL TRANSFERASE	Mb2981, -, len: 275 aa. Equivalent to Rv2957, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Possible glycosyl transferase (EC 2.4.1.-); possibly secreted protein. Highly similar to O88109|GSD|GTFD GSD PROTEIN from Mycobacterium avium subsp. silvaticum, Mycobacterium paratuberculosis, and Mycobacterium avium (266 aa), FASTA scores: opt: 1010, E(): 2.5e-62, (68.8% identity in 221 aa overlap). Also some similarity with other proteins and especially glycosyl transferases e.g. Q9AEE4 HYPOTHETICAL 31.4 KDA PROTEIN from Leptospira interrogans (265 aa),FASTA scores: opt: 371, E(): 3.3e-18, (34.43% identity in 212 aa overlap); Q9EXY4 PUTATIVE GLYCOSYL TRANSFERASE from Escherichia coli (248 aa), FASTA scores: opt: 339, E(): 5e-16, (32.4% identity in 210 aa overlap); Q9RCC4 GLYCOSYLTRANSFERASE-LIKE PROTEIN from Yersinia pestis (247 aa), FASTA scores: opt: 333, E(): 1.3e-15, (31.8% identity in 217 aa overlap); Q9EXY1 PUTATIVE GLYCOSYL TRANSFERASE from Escherichia coli (248 aa), FASTA scores: opt: 328,E(): 2.9e-15, (31.9% identity in 210 aa overlap); etc. Equivalent to AAK47357 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 19 aa.	X2BMC2,P0A5A0	No	intermediary metabolism and respiration								X2BMC2,P0A5A0	P0A5A0				Rv2957		Rv2957			
NC_002945.3	Mycobrowser_v4	CDS	3292647	3293192	.	+	0	Mb3004	Mb3004		POSSIBLE CONSERVED SECRETED PROTEIN	Mb3004, -, len: 181 aa. Equivalent to Rv2980, len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Possible conserved secreted protein, equivalent to Q9CBS1 POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (191 aa), FASTA scores: opt: 794, E(): 2.3e-40, (67.25% identity in 177 aa overlap). Also some weak similarity with other hypothetical proteins or secreted proteins e.g. C-terminus of Q98F98|MLL3872 MLL3872 PROTEIN from Rhizobium loti (Mesorhizobium loti) (575 aa), FASTA scores: opt: 148,E(): 0.16, (28.35% identity in 194 aa overlap); Q9L0W9|SCH22A.13C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 114,E(): 7.5, (40.0% identity in 80 aa overlap); etc. Equivalent to AAK47385 from Mycobacterium tuberculosis strain CDC1551 (214 aa) but shorter 33 aa. Has hydrophobic stretch near N-terminus.	Q7TXI0	No	cell wall and cell processes							IPR021903	Q7TXI0	A0A1R3Y358				Rv2980		Rv2980			
NC_002945.3	Mycobrowser_v4	CDS	3267589	3268689	.	-	0	Mb2982c	Mb2982c		possible glycosyl transferase	Mb2982c, -, len: 366 aa. Similar to 5' end of Rv2958c, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv, (83.3% identity in 371 aa overlap). Possible glycosyl transferase (EC 2.4.1.-), highly similar to Q9CD88|ML0128 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (435 aa), FASTA scores: opt: 2116,E(): 5.8e-126, (75.05% identity in 417 aa overlap); and Q9CD91|ML0125 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2104,E(): 3.3e-125, (74.65% identity in 418 aa overlap). Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3 PUTATIVE GLYCOSYLTRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 317, E(): 1.9e-12, (31.0% identity in 297 aa overlap); Q9S1V2 PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (407 aa), FASTA scores: opt: 264, E(): 4.1e-09, (27.2% identity in 342 aa overlap); P72650|CRTX|SLR1125 ZEAXANTHIN GLUCOSYL TRANSFERASE from Synechocystis sp. strain PCC 6803 (419 aa), FASTA scores: opt: 251, E(): 2.8e-08, (26.8% identity in 295 aa overlap); etc. Very similar to P95130|MTCY349.25 from Mycobacterium tuberculosis (449 aa), FASTA score: opt: 2215, E(): 3.3e-132, (77.25% identity in 422 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	X2BM79,Q7TXJ8	No									X2BM79,Q7TXJ8	Q7TXJ8									
NC_002945.3	Mycobrowser_v4	CDS	3268790	3269527	.	-	0	Mb2983c	Mb2983c		POSSIBLE METHYLTRANSFERASE (METHYLASE)	Mb2983c, -, len: 245 aa. Equivalent to Rv2959c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Possible methyltransferase (EC 2.1.1.-), highly similar to Q9CD89|ML0127 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1183, E(): 3.9e-69, (76.1% identity in 226 aa overlap). Also some similarity with other methyltransferases and other proteins e.g. Q51079 PUTATIVE METHYL TRANSFERASE from Nocardia lactamdurans (236 aa),FASTA scores: opt: 156, E(): 0.0086, (23.25% identity in 159 aa overlap); Q98ID5 CEPHALOSPORIN HYDROXYLASE from Rhizobium loti (Mesorhizobium loti) (217 aa), FASTA scores: opt: 275, E(): 1.7e-10, (29.65% identity in 199 aa overlap); etc. And also similar to P72897 HYPOTHETICAL 27.8 KDA PROTEIN from Mycobacterium tuberculosis (249 aa),FASTA scores: opt: 292, E(): 1.5e-11, (31.25% identity in 208 aa overlap).	X2BMP5,Q7TXJ7	No	intermediary metabolism and respiration								X2BMP5,Q7TXJ7	Q7TXJ7				Rv2959c		Rv2959c			
NC_002945.3	Mycobrowser_v4	CDS	3269642	3269890	.	-	0	Mb2984c	Mb2984c		HYPOTHETICAL PROTEIN	Mb2984c, -, len: 82 aa. Equivalent to Rv2960c, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 82 aa overlap). Hypothetical unknown protein, equivalent to AAK47362 from Mycobacterium tuberculosis strain CDC1551 (116 aa) but shorter 34 aa. Shortened version of MTCY349.28 avoiding overlap.	Q7TXJ6	No	conserved hypotheticals								Q7TXJ6	A0A1R3Y2V7				Rv2960c		Rv2960c			
NC_002945.3	Mycobrowser_v4	CDS	3269972	3270361	.	+	0	Mb2985	Mb2985		PROBABLE TRANSPOSASE	Mb2985, -, len: 129 aa. Equivalent to Rv2961, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Probable transposase,highly similar to C-terminus of O50414|Rv3387|MTV004.45 PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (225 aa), FASTA scores: opt: 605, E(): 7.2e-34, (66.65% identity in 129 aa overlap); and similar to others e.g. CAC47401 PUTATIVE PARTIAL TRANSPOSASE FOR ISRM17 PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (174 aa),FASTA scores: opt: 183, E(): 2.6e-05, (30.25% identity in 129 aa overlap); etc.	Q7TXJ5	No	insertion seqs and phages							IPR002559	Q7TXJ5	A0A1R3Y340				Rv2961		Rv2961			
NC_002945.3	Mycobrowser_v4	CDS	3270462	3271811	.	-	0	Mb2986c	Mb2986c		POSSIBLE GLYCOSYL TRANSFERASE	Mb2986c, -, len: 449 aa. Equivalent to Rv2962c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Possible glycosyl transferase (EC 2.4.1.-), highly similar or identical to Mycobacterium tuberculosis proteins G560522 U0002JA,G560521 U0002H, G560522 U0002JA, G560519 U0002KA. Equivalent (but longer 21 aa) to Q9CD91 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2229, E(): 1.3e-133, (77.45% identity in 426 aa overlap); and highly similar to Q9CD88 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (435 aa),FASTA scores: opt: 2129, E(): 2.7e-127, (74.35% identity in 425 aa overlap); and others from Mycobacterium leprae. Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3|DRA0329 PUTATIVE GLYCOSYL TRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 340, E(): 5.5e-14, (31.2% identity in 330 aa overlap); P72650 ZEAXANTHIN GLUCOSYL TRANSFERASE from Synechocystis sp. (strain PCC 6803) (419 aa), FASTA scores: opt: 244, E(): 6.6e-08, (26.2% identity in 294 aa overlap); etc. Also highly similar to P95134 HYPOTHETICAL 46.8 KDA PROTEIN from Mycobacterium tuberculosis (428 aa),FASTA scores: opt: 2215, E(): 9.6e-133, (77.25% identity in 422 aa overlap).	X2BMC4,Q7TXJ4	No	intermediary metabolism and respiration								X2BMC4,Q7TXJ4	Q7TXJ4				Rv2962c		Rv2962c			
NC_002945.3	Mycobrowser_v4	CDS	3271925	3273145	.	+	0	Mb2987	Mb2987		PROBABLE INTEGRAL MEMBRANE PROTEIN	Mb2987, -, len: 406 aa. Equivalent to Rv2963, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable integral membrane protein.	Q7TXJ3	No	cell wall and cell processes							IPR005524	Q7TXJ3	A0A1R3Y2R0				Rv2963		Rv2963			
NC_002945.3	Mycobrowser_v4	CDS	3291851	3292435	.	-	0	Mb3003c	Mb3003c		PROBABLE RESOLVASE	Mb3003c, -, len: 194 aa. Equivalent to Rv2979c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(98.5% identity in 194 aa overlap). Probable resolvase for IS1538, with low level matches to transposon resolvases; highly similar from aa 101 to YX1C_MYCTU|Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 809, E(): 0, (69.1% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site, and possible helix-turn-helix motiv at aa 2-23.	Q7TXI1	No	insertion seqs and phages							IPR006118,IPR006119	Q7TXI1	A0A1R3Y2X7				Rv2979c		Rv2979c			
NC_002945.3	Mycobrowser_v4	CDS	3275590	3276156	.	-	0	Mb2990c	Mb2990c		POSSIBLE METHYLTRANSFERASE (METHYLASE)	Mb2990c, -, len: 188 aa. Equivalent to Rv2966c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Possible methyltransferase (EC 2.1.1.-), equivalent (but shorter 36 aa) to O69465|MLCB1243.09 HYPOTHETICAL 23.0 KDA PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 872, E(): 9.1e-50, (74.2% identity in 182 aa overlap). Also similar to others e.g. Q9ZBR2|SC7A1.11 PUTATIVE METHYLASE from Streptomyces coelicolor (195 aa), FASTA scores: opt: 510, E(): 3.7e-26, (47.5% identity in 179 aa overlap); Q9F842 HYPOTHETICAL METHYLTRANSFERASE (FRAGMENT) from Mycobacterium smegmatis (80 aa), FASTA scores: opt: 386, E(): 2.5e-18, (75.0% identity in 80 aa overlap); P10120|YHHF_ECOLI|YHHFZ|B3465 PUTATIVE METHYLASE from Escherichia colistrain K12 (198 aa), FASTA scores: opt: 319, E(): 1.1e-13, (35.5% identity in 183 aa overlap); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature.	Q7TXJ2	No	intermediary metabolism and respiration							IPR002052,IPR004398	Q7TXJ2	A0A1R3Y2R5				Rv2966c		Rv2966c			
NC_002945.3	Mycobrowser_v4	CDS	3279760	3280392	.	-	0	Mb2992c	Mb2992c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb2992c, -, len: 210 aa. Equivalent to Rv2968c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 210 aa overlap). Probable conserved integral membrane protein, equivalent to O69464 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (214 aa), FASTA scores: opt: 1060, E(): 1.4e-58, (71.95% identity in 214 aa overlap). Also highly similar to others e.g. Q9F844 HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Mycobacterium smegmatis (187 aa), FASTA scores: opt: 883,E(): 1.2e-47, (62.8% identity in 190 aa overlap); Q9KXP3 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (240 aa), FASTA scores: opt: 503, E(): 4.6e-24,(38.0% identity in 192 aa overlap); etc.	Q7TXJ0	No	cell wall and cell processes							IPR012932	Q7TXJ0	A0A1R3Y4P3				Rv2968c		Rv2968c			
NC_002945.3	Mycobrowser_v4	CDS	3280398	3281165	.	-	0	Mb2993c	Mb2993c		POSSIBLE CONSERVED MEMBRANE OR SECRETED PROTEIN	Mb2993c, -, len: 255 aa. Equivalent to Rv2969c,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Possible conserved membrane or exported protein, equivalent to Q9CBS4|ML1667 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1101, E(): 9.9e-68,(65.9% identity in 258 aa overlap); and highly similar to O69463 PUTATIVE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (258 aa), FASTA scores: opt: 1097, E(): 1.8e-67,(65.5% identity in 258 aa overlap). C-terminus also highly similar to Q9KK65|996A160 EXPORTED PROTEIN (FRAGMENT) from Mycobacterium avium (85 aa), FASTA scores: opt: 418, E(): 2e-21, (72.95% identity in 85 aa overlap). Also weakly similar to membrane or exported proteins e.g. Q9S2U7|SC4G6.04c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (275 aa), FASTA scores: opt: 312,E(): 7.6e-14, (28.25% identity in 230 aa overlap); Q9XAB6|SCC22.22C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (255 aa), FASTA scores: opt: 181,E(): 6.4e-05, (27.0% identity in 226 aa overlap); etc. Also some similarity with P72001|PKNE_MYCTU from Mycobacterium tuberculosis (566 aa), FASTA scores: opt: 264, E(): 2.3e-10, (30.5% identity in 177 aa overlap).	Q7TXI9	No	cell wall and cell processes							IPR012336	Q7TXI9	A0A1R3Y3I9				Rv2969c		Rv2969c			
NC_002945.3	Mycobrowser_v4	CDS	4249039	4249815	.	+	0	Mb3869	Mb3869		CONSERVED HYPOTHETICAL PROTEIN	Mb3869, -, len: 258 aa. Equivalent to Rv3839, len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 258 aa overlap). Conserved hypothetical protein, similar in part to Q9RD78|SCF43.10cfrom HYPOTHETICAL 25.8 KDA PROTEIN Streptomyces coelicolor (241 aa), FASTA scores: opt: 270, E(): 3.2e-10, (33.45% identity in 272 aa overlap); and O00320|F25451_2 HYPOTHETICAL PROTEIN from Homo sapiens (Human) (339 aa),FASTA scores: opt: 126, E(): 0.77, (28.75% identity in 240 aa overlap).	Q7TVJ5	No	conserved hypotheticals							IPR012349	Q7TVJ5	A0A1R3Y5F0				Rv3839		Rv3839			
NC_002945.3	Mycobrowser_v4	CDS	3283712	3284425	.	-	0	Mb2997c	Mb2997c		POSSIBLE CONSERVED MEMBRANE OR EXPORTED PROTEIN	Mb2997c, -, len: 237 aa. Equivalent to Rv2972c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Possible conserved membrane or exported protein, equivalent (but longer 52 aa) to O69461|MLCB1243.02 HYPOTHETICAL 20.5 KDA PROTEIN from Mycobacterium leprae (180 aa), FASTA scores: opt: 581, E(): 8.2e-32, (55.75% identity in 174 aa overlap). Also similar to membrane or exported proteins e.g. Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 498, E(): 4.1e-26,(44.08% identity in 186 aa overlap); Q99QB5|SCP1.323C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (219 aa), FASTA scores: opt: 329, E(): 8.5e-15, (36.35% identity in 176 aa overlap); Q9ACQ1|SCP1.267 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (219 aa),FASTA scores: opt: 286, E(): 6.6e-12, (32.03% identity in 231 aa overlap); etc.	Q7TXI5	No	cell wall and cell processes							IPR011089	Q7TXI5					Rv2972c		Rv2972c			
NC_002945.3	Mycobrowser_v4	CDS	3286638	3288299	.	-	0	Mb2999c	Mb2999c		conserved hypothetical protein	Mb2999c, -, len: 553 aa. Equivalent to Rv2975c and Rv2974c, len: 84 aa and 470 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 83 aa overlap and 100.0% identity in 470 aa overlap). Rv2975c: Conserved hypothetical protein, similar to N-terminus of others e.g. Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA PROTEIN from Streptomyces coelicolor (589 aa), FASTA scores: opt: 141, E(): 0.0019, (41.25% identity in 80 aa overlap); Q98R49|MYPU_1610 HYPOTHETICAL PROTEIN from Mycoplasma pulmonis (545 aa), FASTA scores: opt: 127, E(): 0.023,(48.0% identity in 50 aa overlap); Q9K9Z6|BH2498 HYPOTHETICAL PROTEIN from Bacillus halodurans (557 aa),FASTA scores: opt: 126, E(): 0.028, (34.55% identity in 81 aa overlap); etc. Also some similarity with N-terminus of P47609|Y369_MYCGE|MG369 HYPOTHETICAL PROTEIN from Mycoplasma genitalium (557 aa), FASTA scores: opt: 108,E(): 0.7, (36.75% identity in 49 aa overlap); this, and preceding ORF, are similar to Y369_MYCGE and YLOV PROTEIN but no cosmid sequence error was identified. Rv2974c: Conserved hypothetical ala-rich protein, highly similar to others e.g. C-terminus of Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA PROTEIN from Streptomyces coelicolor (589 aa),FASTA scores: opt: 774, E(): 1.3e-36, (41.0% identity in 495 aa overlap); Q9K9Z6|BH2498 HYPOTHETICAL PROTEIN from Bacillus halodurans (557 aa), FASTA scores: opt: 268, E(): 8e-08, (27.7% identity in 502 aa overlap) (N-terminus longer 76 aa); Q9X293 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (497 aa), FASTA scores: opt: 265, E(): 1.1e-07, (24.9% identity in 470 aa overlap) (N-terminus longer 43 aa); etc. Also some similarity with P47609|Y369_MYCGE|MG369 HYPOTHETICAL PROTEIN from Mycoplasma genitalium (557 aa), FASTA scores: opt: 154,E(): 0.25, (20.25% identity in 489 aa overlap); this, and following ORF, are similar to Y369_MYCGE but no cosmid sequence error was identified. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis, a 2 bp deletion (cg-*) results in a single product that is more similar to Rv2974c.	Q7TXI4	No	conserved hypotheticals							IPR004007,IPR019986	Q7TXI4					Rv2975c		Rv2975c			
NC_002945.3	Mycobrowser_v4	CDS	3427960	3428397	.	-	0	Mb3130c	Mb3130c		HYPOTHETICAL PROLINE-RICH PROTEIN	Mb3130c, -, len: 145 aa. Equivalent to Rv3103c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Hypothetical unknown pro-rich protein, with some similarity to Proline-rich proteins e.g. Q39789 PROLINE-RICH CELL WALL PROTEIN from Gossypium hirsutum (Upland cotton) (214 aa), FASTA scores: opt: 267, E(): 0.00014, (40% identity in 110 aa overlap). Equivalent to AAK47525 from M. mycobacterium strain CDC1551 (158 aa) but shorter 13 aa.	Q7TX89	No	conserved hypotheticals								Q7TX89					Rv3103c		Rv3103c			
NC_002945.3	Mycobrowser_v4	CDS	3290472	3291851	.	-	0	Mb3002c	Mb3002c		probable transposase	Mb3002c, -, len: 459 aa. Equivalent to Rv2978c,len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable resolvase for IS1538, with low level matches to transposon resolvases; highly similar from aa 101 to YX1C_MYCTU|Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 809, E(): 0, (69.1% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site, and possible helix-turn-helix motiv at aa 2-23.	Q7TXI2	No	insertion seqs and phages							IPR001959,IPR010095,IPR021027	Q7TXI2					Rv2978c		Rv2978c			
NC_002945.3	Mycobrowser_v4	CDS	3295678	3296322	.	+	0	Mb3007	Mb3007		CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN	Mb3007, -, len: 214 aa. Equivalent to Rv2983, len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical ala-rich protein, equivalent to O33128|ML1680|MLCB637.37c HYPOTHETICAL 22.0 KDA PROTEIN from Mycobacterium leprae (216 aa), FASTA scores: opt: 1080, E(): 9e-61, (79.05% identity in 215 aa overlap). Also similar to other hypothetical proteins e.g. Q9ZBS2|SC7A1.01C from Streptomyces coelicolor (212 aa),FASTA scores: opt: 420, E(): 2.9e-19, (43.5% identity in 207 aa overlap); O26710|MTH613 from Methanothermobacter thermautotrophicus (223 aa), FASTA scores: opt: 193, E(): 5.8e-05, (30.0% identity in 190 aa overlap); Q9RKG8|SCE46.21 from Streptomyces coelicolor (210 aa),FASTA scores: opt: 139, E(): 0.14, (27.65% identity in 206 aa overlap); etc.	X2BMR6,Q7TXH8	No	conserved hypotheticals								X2BMR6,Q7TXH8					Rv2983		Rv2983			
NC_002945.3	Mycobrowser_v4	CDS	3302707	3303408	.	+	0	Mb3013	Mb3013		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb3013, -, len: 233 aa. Equivalent to Rv2989, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Probable transcriptional regulator (ala-rich protein), highly similar to O86533|SC1C2.33c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (238 aa), FASTA scores: opt: 711, E(): 2.3e-38, (53.05% identity in 230 aa overlap); and similar to others e.g. Q9KND6 PUTATIVE TRANSCRIPTIONAL REGULATOR from Vibrio cholerae (244 aa),FASTA scores: opt: 232, E(): 1.2e-07, (29.75% identity in 232 aa overlap); Q9R9U0|SRPS EFFLUX PUMP REGULATOR from Pseudomonas putida (259 aa), FASTA scores: opt: 224, E(): 4.1e-07, (28.35% identity in 247 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O06806|Rv1773c|MTCY28.39 HYPOTHETICAL 26.6 KDA PROTEIN (248 aa), FASTA scores: opt: 239, E(): 4.4e-08, (29.85% identity in 231 aa overlap); P71977|RV1719|MTCY04C12.04 HYPOTHETICAL 27.9 KDA PROTEIN (259 aa), FASTA scores: opt: 215, E(): 1.6e-06, (31.85% identity in 223 aa overlap); etc. Equivalent to AAK47396 from Mycobacterium tuberculosis strain CDC1551 (267 aa) but shorter 34 aa. Contains possible helix-turn-helix motif at aa 25-46 (Score 1005, +2.61 SD).	Q7TXH5	No	regulatory proteins							IPR005471,IPR011991,IPR014757	Q7TXH5					Rv2989		Rv2989			
NC_002945.3	Mycobrowser_v4	CDS	3313840	3314043	.	-	0	Mb3023c	Mb3023c		CONSERVED HYPOTHETICAL PROTEIN	Mb3023c, -, len: 67 aa. Equivalent to Rv2998A, len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable conserved hypothetical protein, (possibly gene fragment), highly similar to central part of two-component sensor proteins e.g. O07777|Rv0601c|MTCY19H5.21 TWO COMPONENT SENSOR (FRAGMENT) from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 212, E(): 3.7e-09, (58.2% identity in 67 aa overlap); Q9L2B6|SC8F4.08 PROBABLE TWO-COMPONENT SENSOR KINASE from Streptomyces coelicolor (478 aa), FASTA scores: opt: 193, E(): 2.6e-07, (47.05% identity in 68 aa overlap); etc.	Q7TXG9	No	conserved hypotheticals							IPR003660,IPR003661,IPR009082	Q7TXG9					Rv2998A		Rv2998A			
NC_002945.3	Mycobrowser_v4	CDS	3306834	3307553	.	-	0	Mb3017c	Mb3017c		POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE)	Mb3017c, -, len: 239 aa. Equivalent to Rv2993c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-), equivalent to O33119|ML1689|MLCB637.28 POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE- 1,7-DIOATE ISOMERASE from Mycobacterium leprae (242 aa), FASTA scores: opt: 1427,E(): 4.4e-86, (85.9% identity in 241 aa overlap). Also similar to others e.g. Q9LBE3|DR1609 from Deinococcus radiodurans (250 aa), FASTA scores: opt: 723, E(): 5.5e-40, (49.05% identity in 216 aa overlap); O27551|MTH1507 from Methanothermobacter thermautotrophicus (260 aa), FASTA scores: opt: 708, E(): 5.4e-39, (52.1% identity in 213 aa overlap); Q9HQR6|VNG1037G|HPCE from Halobacterium sp. (strain NRC-1) (244 aa), FASTA scores: opt: 590, E(): 2.7e-31, (43.65% identity in 220 aa overlap); etc. Start chosen by homology, but ORF could continue upstream. TBparse score is 0.896.	Q7TXH2	No	intermediary metabolism and respiration							IPR002529,IPR011234,IPR018833	Q7TXH2					Rv2993c		Rv2993c			
NC_002945.3	Mycobrowser_v4	CDS	3304542	3305033	.	+	0	Mb3015	Mb3015		conserved protein	Mb3015, -, len: 163 aa. Equivalent to Rv2991, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 163 aa overlap). Conserved hypothetical protein, similar to others e.g. Q9K3X7|2SCG61.39. HYPOTHETICAL 17.6 KDA PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 HYPOTHETICAL PROTEIN from Pasteurella multocida (171 aa), FASTA scores: opt: 175, E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163, E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06553|MTCI65.22|Rv1155 hypothetical protein from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 127, E(): 0.1, (32.9% identity in 73 aa overlap); and to several proteins of similar size that confer resistance to 5-Nitroimidazole antibiotics in Bacteroides.	Q7TXH3	No	conserved hypotheticals							IPR011576,IPR012349,IPR019920	Q7TXH3					Rv2991		Rv2991			
NC_002945.3	Mycobrowser_v4	CDS	3311715	3313157	.	+	0	Mb3021	Mb3021		POSSIBLE ALANINE RICH DEHYDROGENASE	Mb3021, -, len: 480 aa. Equivalent to Rv2997, len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 480 aa overlap). Possible ala-rich dehydrogenase (EC 1.-.-.-), similar to others dehydrogenases and hypothetical proteins e.g. Q9EYI5 PUTATIVE DEHYDROGENASE from Streptomyces nogalater (472 aa), FASTA scores: opt: 1131, E(): 1.7e-61, (41.0% identity in 471 aa overlap); Q9ZBG4|SC9B5.16 PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (472 aa), FASTA scores: opt: 1064, E(): 2e-57, (39.05% identity in 471 aa overlap); Q98BS8 PROBABLE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (524 aa), FASTA scores: opt: 196, E(): 0.00021, (25.1% identity in 526 aa overlap); etc. Shows strong simlarity throughout its length to O06826|MTCY493.22c|Rv1432 HYPOTHETICAL 50.5 KDA PROTEIN from Mycobacterium tuberculosis (473 aa), FASTA scores: opt: 1220, E(): 6.1e-67, (42.35% identity in 465 aa overlap).	Q7TXH1	No	intermediary metabolism and respiration								Q7TXH1					Rv2997		Rv2997			
NC_002945.3	Mycobrowser_v4	CDS	3313430	3313891	.	+	0	Mb3022	Mb3022		HYPOTHETICAL PROTEIN	Mb3022, -, len: 153 aa. Equivalent to Rv2998, len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Hypothetical unknown protein. Note that equivalent to AAK47405 Hypothetical 19.4 kDa protein from Mycobacterium tuberculosis strain CDC1551 (186 aa) but sequence differs in N-terminus.	Q7TXH0	No	conserved hypotheticals								Q7TXH0					Rv2998		Rv2998			
NC_002945.3	Mycobrowser_v4	CDS	3320308	3321147	.	-	0	Mb3030c	Mb3030c		CONSERVED HYPOTHETICAL PROTEIN	Mb3030c, -, len: 279 aa. Equivalent to Rv3005c,len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Conserved hypothetical protein, equivalent to O33110|MLCB637.18|ML1698 HYPOTHETICAL 29.5 KDA PROTEIN from Mycobacterium leprae (277 aa), FASTA scores: opt: 1245, E(): 1.2e-65, (70.5% identity in 278 aa overlap). Also similar, but longer 100 aa in N-terminus, to other hypothetical proteins, few membrane proteins, e.g. Q9RKN9|SCC75A.35 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 326,E(): 3.9e-12, (44.2% identity in 138 aa overlap); P96694|YDFP|AB001488 HYPOTHETICAL PROTEIN from Bacillus subtilis (129 aa), FASTA scores: opt:273, E(): 3.7e-09,(33.1% identity in 130 aa overlap); Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from Vibrio cholerae (148 aa), FASTA scores: opt: 258, E(): 3.1e-08, (34.9% identity in 126 aa overlap); etc.	Q7TXG6	No	conserved hypotheticals							IPR011637	Q7TXG6					Rv3005c		Rv3005c			
NC_002945.3	Mycobrowser_v4	CDS	3315227	3315886	.	+	0	Mb3025	Mb3025		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3025, -, len: 219 aa. Equivalent to Rv3000, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Possible conserved transmembrane protein, similar to various membrane proteins e.g. P77307|YBBM_ECOLI|B0491 HYPOTHETICAL 28.2 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain K12 (259 aa), FASTA scores: opt: 292, E(): 3.1e-11, (30.25% identity in 218 aa overlap); N-terminus of Q9BJF3 PUTATIVE ABC TRANSPORTER (FRAGMENT) from Sterkiella histriomuscorum (1319 aa), FASTA scores: opt: 274, E(): 1.3e-09, (39.6% identity in 101 aa overlap); Q9C9W0|T23K23.21 PUTATIVE ABC TRANSPORTER from Arabidopsis thaliana (Mouse-ear cress) (263 aa), FASTA scores: opt: 258, E(): 4.4e-09, (30.1% identity in 196 aa overlap); P74369|YG47_SYNY3|SLR1647 HYPOTHETICAL 28.1 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Synechocystis sp. strain PCC 6803 (259 aa), FASTA scores: opt: 257, E(): 5.1e-09, (37.75% identity in 98 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TXG7	No	cell wall and cell processes							IPR003439,IPR005226,IPR027417	Q7TXG7					Rv3000		Rv3000			
NC_002945.3	Mycobrowser_v4	CDS	3353774	3354850	.	-	0	Mb3063c	Mb3063c		CONSERVED HYPOTHETICAL PROTEIN	Mb3063c, -, len: 358 aa. Equivalent to Rv3037c,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 358 aa overlap). Conserved hypothetical protein, similar in part to others e.g. O86799|SC6G4.36c from Streptomyces coelicolor (426 aa), FASTA scores: opt: 545, E(): 5.5e-27, (36.15% identity in 354 aa overlap); Q9UZW6|PAB0687 from Pyrococcus abyssi (386 aa), FASTA scores: opt: 262, E(): 3.5e-09, (31.0% identity in 200 aa overlap).	Q7TXE3	No	conserved hypotheticals								Q7TXE3	A0A1R3Y3B9				Rv3037c		Rv3037c			
NC_002945.3	Mycobrowser_v4	CDS	3322451	3323065	.	-	0	Mb3032c	Mb3032c		POSSIBLE OXIDOREDUCTASE	Mb3032c, -, len: 204 aa. Equivalent to Rv3007c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to Q9EWU5|3SC5B7.04c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (162 aa), FASTA scores: opt: 376, E(): 1.5e-18, (41.35% identity in 150 aa overlap); Q9K416|SCG22.29c PUTATIVE FLAVIN-DEPENDENT REDUCTASE PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 246, E(): 1e-09,(34.1% identity in 135 aa overlap); and some similarity to coupling proteins of 4-hydroxyphenylacetic hydroxylase/monooxygenase e.g. Q9HWT6|HPAC|PA4092 Pseudomonas aeruginosa (170 aa), FASTA score: opt: 214; O68232|HPAC Photorhabdus luminescens (Xenorhabdus luminescens) (172 aa), FASTA score: opt: 198; Q9RPU2|HPAC Salmonella dublin (170 aa), FASTA score: opt: 197; etc. Equivalent to AAK47416 from Mycobacterium tuberculosis strain CDC1551 (236 aa) but shorter 32 aa. Start chosen by similarity.	Q7TXG4	No	intermediary metabolism and respiration							IPR002563,IPR012349	Q7TXG4	A0A1R3Y3M9				Rv3007c		Rv3007c			
NC_002945.3	Mycobrowser_v4	CDS	3424960	3425811	.	-	0	Mb3126c	Mb3126c		conserved protein	Mb3126c, -, len: 283 aa. Equivalent to Rv3099c,len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Conserved hypothetical protein, some similarity with hypothetical proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 384, E(): 1.8e-17, (32.7% identity in 269 aa overlap); and P71606|Y036_MYCTU|Rv0036c from Mycobacterium tuberculosis strain H37Rv (257 aa),FASTA scores: opt: 179, E(): 0.00024, (25.85% identity in 205 aa overlap).	Q7TX92	No	conserved hypotheticals							IPR010872,IPR017517,IPR024344,IPR027369	Q7TX92	A0A1R3Y335				Rv3099c		Rv3099c			
NC_002945.3	Mycobrowser_v4	CDS	3414758	3415645	.	+	0	Mb3117	Mb3117		unknown alanine and valine rich protein	Mb3117, -, len: 295 aa. Equivalent to Rv3090, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Hypothetical unknown Ala-, Val-rich protein. Hydrophobic stretch at N-terminus.	Q7TXA0	No	conserved hypotheticals							IPR001107	Q7TXA0	A0A1R3Y326				Rv3090		Rv3090			
NC_002945.3	Mycobrowser_v4	CDS	3331266	3332279	.	-	0	Mb3040c	Mb3040c		CONSERVED HYPOTHETICAL PROTEIN	Mb3040c, -, len: 337 aa. Equivalent to Rv3015c,len: 337 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 337 aa overlap). Conserved hypothetical protein, equivalent to Q9CBR6|ML1706 HYPOTHETICAL PROTEIN from Mycobacterium leprae (337 aa),FASTA scores: opt: 1703, E(): 3.1e-92, (78.05% identity in 337 aa overlap); and (but longer 47 aa) O33101|MLCB637.09 HYPOTHETICAL 30.0 KDA PROTEIN from Mycobacterium leprae (290 aa), FASTA scores: opt: 1564, E(): 2.4e-78, (78.6% identity in 290 aa overlap). Also similar to Q9Z586|SC8D9.05 HYPOTHETICAL 35.0 KDA PROTEIN from Streptomyces coelicolor (331 aa), FASTA scores: opt: 774,E(): 4.7e-38, (43.4% identity in 334 aa overlap); and showing similarity with other proteins e.g. Q39586|METE_CHLRE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE from Chlamydomonas reinhardtii (814 aa),FASTA scores: opt: 162, E(): 0.048, (27.05% identity in 355 aa overlap).	Q7TXG0	No	conserved hypotheticals							IPR002629	Q7TXG0	A0A1R3Y2W5				Rv3015c		Rv3015c			
NC_002945.3	Mycobrowser_v4	CDS	3337935	3339182	.	-	0	Mb3049c	Mb3049c		PROBABLE TRANSPOSASE	Mb3049c, -, len: 415 aa. Equivalent to Rv3023c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 415 aa overlap). Probable IS1081 transposase. Contains PS01007 Transposases, Mutator family, signature. Similars to P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c and Rv2512c|MTCY07A7.18c TRANSPOSASES FOR INSERTION SEQUENCE ELEMENT IS1081 (415 aa), FASTA scores: opt: 2675, E(): 1.8e-162, (100.0% identity in 415 aa overlap). TBparse score is 0.894. BELONGS TO THE MUTATOR FAMILY OF TRANSPOSASE.	X2BGW7,P60231	No	insertion seqs and phages								X2BGW7,P60231	P60231				Rv3023c		Rv3023c			
NC_002945.3	Mycobrowser_v4	CDS	3345661	3346485	.	+	0	Mb3056	Mb3056		conserved protein	Mb3056, -, len: 274 aa. Equivalent to Rv3030, len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Conserved hypothetical protein, equivalent to O33094|MLCB637.02c|ML1713 hypothetical 30.8 KDa protein from Mycobacterium leprae (280 aa), FASTA scores: opt: 1388, E(): 5.5e-83, (78.2% identity in 280 aa overlap). N-terminus has similarity to hypothetical proteins from a number of organisms and to Q54303|EMBL:X86780|RAPM methyltransferase from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 191, E(): 3.6e-05, (35.65% identity in 101 aa overlap).	Q7TXF0	No	conserved hypotheticals							IPR013216	Q7TXF0	A0A1R3Y2Y0				Rv3030		Rv3030			
NC_002945.3	Mycobrowser_v4	CDS	3341723	3342637	.	-	0	Mb3052c	Mb3052c		CONSERVED HYPOTHETICAL PROTEIN	Mb3052c, -, len: 304 aa. Equivalent to Rv3026c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Conserved hypothetical protein, similar to Q9RCZ0|SCM10.08C PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (275 aa),FASTA scores: opt: 393, E(): 2.2e-17, (41.4% identity in 299 aa overlap). Similar in part to other hypothetical proteins and acyltransferases e.g. BAB51968|MLR5533 from Rhizobium loti (266 aa), FASTA scores: opt: 280, E(): 2.4e-10, (29.45% identity in 258 aa overlap); Q9KIH9 PUTATIVE ACYLTRANSFERASE (PUTATIVE ACYLTRANSFERASE TRANSMEMBRANE PROTEIN) (EC 2.3.1.) from Rhizobium meliloti (Sinorhizobium meliloti) (292 aa), FASTA scores: opt: 252,E(): 1.4e-08, (30.5% identity in 210 aa overlap); O69114|PLSC PUTATIVE 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE from Burkholderia pseudomallei (Pseudomonas pseudomallei) (289 aa), FASTA scores: opt: 216, E(): 2.4e-06, (30.85% identity in 269 aa overlap); etc. So may be a member of acyltransferase family protein.	Q7TXF3	No	conserved hypotheticals							IPR002123	Q7TXF3	A0A1R3Y3N4				Rv3026c		Rv3026c			
NC_002945.3	Mycobrowser_v4	CDS	3441861	3442331	.	+	0	Mb3145	Mb3145		HYPOTHETICAL PROTEIN	Mb3145, -, len: 155 aa. Equivalent to Rv3122, len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 155 aa overlap). Hypothetical unknown protein.	Q7TX79	No	conserved hypotheticals								Q7TX79	A0A1R3Y361				Rv3122		Rv3122			
NC_002945.3	Mycobrowser_v4	CDS	3442341	3442835	.	+	0	Mb3146	Mb3146		HYPOTHETICAL PROTEIN	Mb3146, -, len: 164 aa. Equivalent to Rv3123, len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 164 aa overlap). Hypothetical unknown protein, but N-terminus shares weak similarity with N-terminal part of O93439|CMESO-1 BHLH TRANSCRIPTION FACTOR from Gallus gallus (Chicken) (287 aa), FASTA scores: opt: 129, E(): 0.81, (38.75% identity in 80 aa overlap).	Q7TX78	No	conserved hypotheticals								Q7TX78	A0A1R3Y355				Rv3123		Rv3123			
NC_002945.3	Mycobrowser_v4	CDS	3722262	3722522	.	-	0	Mb3388c	Mb3388c		CONSERVED HYPOTHETICAL PROTEIN	Mb3388c, -, len: 86 aa. Equivalent to Rv3353c, len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Hypothetical protein,showing some similarity to Q9X5Q4|MITR MITR PROTEIN from Streptomyces lavendulae (514 aa), FASTA scores: opt: 134,E(): 0.09, (29.5% identity in 78 aa overlap); and weak to Q49720|B1549_C3_218 from Mycobacterium leprae (222 aa),FASTA scores: opt: 99, E(): 8.8, (32.9% identity in 76 aa overlap). But highly similar to N-terminal part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from M. tuberculosis (479 aa), FASTA scores: opt: 305, E(): 4.9e-13, (52.9% identity in 87 aa overlap); and some similarity can be found with Rv3352c and Rv3351c. All show similarity to a family of oxidoreductases in M. tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found. Start changed since original submission.	Q7TWN3	No	conserved hypotheticals								Q7TWN3	A0A1R3Y3Y5				Rv3353c		Rv3353c			
NC_002945.3	Mycobrowser_v4	CDS	3387975	3388385	.	+	0	Mb3094	Mb3094		CONSERVED HYPOTHETICAL PROTEIN	Mb3094, -, len: 136 aa. Equivalent to Rv3067, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Conserved hypothetical protein, weakly similar to other mycobacterium proteins e.g. O53953|Rv1804c|MTV049.26c (108 aa), FASTA scores: opt: 183, E(): 0.00053, (36.6% identity in 82 aa overlap); O07222|Rv1810|MTCY16F9.04c (118 aa),FASTA scores: opt: 149, E(): 0.05, (30.95% identity in 84 aa overlap). Has hydrophobic stretch at N-terminus. Start chosen on basis of codon usage but upstream ATG also possible.	Q7TXB9	No	conserved hypotheticals							IPR007969	Q7TXB9	A0A1R3Y301				Rv3067		Rv3067			
NC_002945.3	Mycobrowser_v4	CDS	3346482	3348062	.	+	0	Mb3057	Mb3057		conserved protein	Mb3057, -, len: 526 aa. Equivalent to Rv3031, len: 526 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 526 aa overlap). Conserved hypothetical protein, equivalent to Q9CBR4|ML1714 HYPOTHETICAL PROTEIN from Mycobacterium leprae (522 aa),FASTA scores: opt: 3167, E(): 4.4e-190, (86.15% identity in 526 aa overlap); and highly similar to truncated O33093|MLCB637.01c HYPOTHETICAL 37.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (338 aa), FASTA scores: opt: 2041, E(): 5.7e-120, (84.8% identity in 342 aa overlap). Also some similarity to hypothetical proteins Q9V0M7|PAB1857 from Pyrococcus abyssi (602 aa), FASTA scores: opt: 477, E(): 3.5e-22, (31.2% identity in 556 aa overlap); and Synechocystis P74630|D90916|SLL0735 from Synechocystis sp. strain PCC 6803 (529 aa), FASTA scores: opt: 282, E(): 4.7e-10, (28.6% identity in 560 aa overlap).	Q7TXE9	No	conserved hypotheticals							IPR004300,IPR011330,IPR015293,IPR027291	Q7TXE9	A0A1R3Y2X1				Rv3031		Rv3031			
NC_002945.3	Mycobrowser_v4	CDS	3356752	3357618	.	-	0	Mb3066c	Mb3066c		conserved protein	Mb3066c, -, len: 288 aa. Equivalent to Rv3040c,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap). Conserved hypothetical protein, highly similar to Q9XA40|SCH17.07c hypothetical protein from Streptomyces coelicolor (312 aa), FASTA scores: opt: 648, E(): 5.2e-34, (50.0% identity in 260 aa overlap). Also similar to Q9F7R7 PREDICTED MUTT SUPERFAMILY HYDROLASE from uncultured proteobacterium EBAC31A08 (264 aa), FASTA scores: opt: 295, E(): 1.3e-11,(27.2% identity in 257 aa overlap); AAK24293|CC2322 hypothetical protein from Caulobacter crescentus (254 aa),BLAST scores: 185 (32% identity) AND 131 (37% identity),etc.	Q7TXE0	No	conserved hypotheticals							IPR000086,IPR015797	Q7TXE0	A0A1R3Y2Y1				Rv3040c		Rv3040c			
NC_002945.3	Mycobrowser_v4	CDS	3348094	3349338	.	+	0	Mb3058	Mb3058		alpha (1->4) glucosyltransferase	Mb3058, -, len: 414 aa. Equivalent to Rv3032, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Possible transferase (EC 2.-.-.-), equivalent to Q9CBR3|ML1715 PUTATIVE TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2456, E(): 7.3e-145, (87.9% identity in 414 aa overlap). Also similar to hypothetical proteins and various transferases e.g. P73369|SLL1971 HYPOTHETICAL 46.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (404 aa), FASTA scores: opt: 584, E(): 7.3e-29, (34.5% identity in 400 aa overlap); Q9Z5B7|SC2G5.06 PUTATIVE TRANSFERASE from Streptomyces coelicolor (406 aa), FASTA scores: opt: 509, E(): 3.3e-24, (35.9% identity in 413 aa overlap); Q9UZA1|PAB0827 GALACTOSYLTRANSFERASE (LPS BIOSYNTHESIS RFBU RELATED PROTEIN) from Pyrococcus abyssi (371 aa),FASTA scores: opt: 381, E(): 2.6e-16, (26.75% identity in 404 aa overlap); etc.	Q7TXE8	No	intermediary metabolism and respiration							IPR001296	Q7TXE8	A0A1R3Y2W8				Rv3032		Rv3032			
NC_002945.3	Mycobrowser_v4	CDS	3349372	3349761	.	+	0	Mb3058A	Mb3058A		Conserved protein	Mb3058A, len: 129 aa. Equivalent to Rv3032A len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BM67	No	conserved hypotheticals								X2BM67	A0A1R3Y2X8				Rv3032A		Rv3032A			
NC_002945.3	Mycobrowser_v4	CDS	3349940	3350488	.	+	0	Mb3059	Mb3059		unknown protein	Mb3059, -, len: 182 aa. Equivalent to Rv3033, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Hypothetical unknown protein.	Q7TXE7	No	conserved hypotheticals							IPR025637	Q7TXE7	A0A1R3Y2Y5				Rv3033		Rv3033			
NC_002945.3	Mycobrowser_v4	CDS	3307885	3309222	.	+	0	Mb3018	Mb3018		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3018, -, len: 445 aa. Equivalent to Rv2994, len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug. C-terminal part highly similar to O33118|MLCB637.27c HYPOTHETICAL 14.7 KDA PROTEIN (probable pseudogene product) from Mycobacterium leprae (134 aa), FASTA scores: opt: 483, E(): 2.7e-21, (60.9% identity in 138 aa overlap). Also similar to various transporters e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 289, E(): 1.3e-09,(26.05% identity in 399 aa overlap); O30210|AF0025 CYANATE TRANSPORT PROTEIN from Archaeoglobus fulgidus (393 aa),FASTA scores: opt: 281, E(): 3.7e-09, (24.05% identity in 399 aa overlap); Q9RI35|SCJ12.25C PUTATIVE NITRATE/NITRITE TRANSPORTER from Streptomyces coelicolor (412 aa), FASTA scores: opt: 264, E(): 3.8e-08, (24.95% identity in 409 aa overlap); Q9A5N5|CC2412 MAJOR FACILITATOR FAMILY TRANSPORTER from Caulobacter crescentus (405 aa), FASTA scores: opt: 263, E(): 4.3e-08, (27.55% identity in 399 aa overlap); etc. First start taken; similarity to P21191|NORA_STAAU QUINOLONE RESISTANCE PROTEIN from Staphylococcus aureus (388 aa) suggests alternative start at 7319 but then no positively charged aa before first transmembrane segment.	Q7TVB6,A0A1R3Y2S6	No	cell wall and cell processes			A0A1R3Y2S6				IPR011701,IPR016196,IPR020846	Q7TVB6					Rv2994		Rv2994			
NC_002945.3	Mycobrowser_v4	CDS	3350579	3351481	.	-	0	Mb3060c	Mb3060c		POSSIBLE TRANSFERASE	Mb3060c, -, len: 300 aa. Equivalent to Rv3034c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Possible transferase (2.-.-.-), equivalent to AAK47449|MT3119 Hexapeptide transferase family protein from Mycobacterium tuberculosis strain CDC1551 but N-terminus shorter 39 residues (262 aa), FASTA scores: opt: 1773, E(): 4.7e-105, (100.0% identity in 262 aa overlap). Similar to Q9CBR1|ML1719 from Mycobacterium leprae but also shorter in N-terminus (245 aa), FASTA scores: opt: 1549, E(): 6.6e-91, (90.6% identity in 244 aa overlap). Some weakly similarity with other transferases (C-terminal part shows some similarity to acetyltransferase from Methanococcus jannaschii (214 aa)). Alternative start possible at 3395077 but codon usage not as good.	Q7TXE6	No	intermediary metabolism and respiration							IPR001451,IPR011004	Q7TXE6	A0A1R3Y4U7				Rv3034c		Rv3034c			
NC_002945.3	Mycobrowser_v4	CDS	3354985	3355968	.	-	0	Mb3064c	Mb3064c		conserved protein	Mb3064c, -, len: 327 aa. Equivalent to Rv3038c,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 327 aa overlap). Conserved hypothetical protein, equivalent to Q9CBQ9|ML1723 HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa),FASTA scores: opt: 1843, E(): 6.1e-108, (80.75% identity in 327 aa overlap). Weak similarity with e.g. Q9KZI3|SCG8A.16 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (199 aa), FASTA scores: opt: 227,E(): 3.9e-07, (31.95% identity in 191 aa overlap) and O52570 METHYLTRANSFERASE from Amycolatopsis mediterranei (272 aa), FASTA scores: opt: 228, E(): 4.3e-07, (31.7% identity in 164 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature but shows no similarity to known LysR family members.	Q7TXE2	No	conserved hypotheticals							IPR013216	Q7TXE2	A0A1R3Y2X3				Rv3038c		Rv3038c			
NC_002945.3	Mycobrowser_v4	CDS	3372627	3373241	.	+	0	Mb3081	Mb3081		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3081, -, len: 204 aa. Equivalent to Rv3055, len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Possible transcriptional regulatory protein, similar to Q9RD23|SCM1.20c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (234 aa), FASTA scores: opt: 471, E(): 4.6e-23, (44.9% identity in 187 aa overlap); and with low similarity to other e.g. Q9ADK8|2SCK31.12 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (198 aa), FASTA scores: opt: 208, 2.5e-06, (32.9% identity in 155 aa overlap); Q9ADD9|SCBAC20F6.11c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (199 aa),FASTA scores: opt: 182, E(): 0.00012, (31.0% identity in 184 aa overlap). Contains potential helix-turn-helix motif from aa 48 to 69 (+3.42 SD). SO MAY BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TXC9	No	regulatory proteins							IPR001647,IPR009057,IPR015893	Q7TXC9	A0A1R3Y3Q9				Rv3055		Rv3055			
NC_002945.3	Mycobrowser_v4	CDS	3357615	3358478	.	-	0	Mb3067c	Mb3067c		PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER	Mb3067c, -, len: 287 aa. Equivalent to Rv3041c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). Probable conserved ATP-binding protein ABC transporter (see citation below),equivalent to Q9CBQ7|ML1726 PUTATIVE ABC TRANSPORTER PROTEIN ATP-BINDING PROTEIN from Mycobacterium leprae (305 aa), FASTA scores: opt: 1576, E(): 8.6e-85, (83.4% identity in 289 aa overlap). Also similar to other putative ATP-binding proteins ABC transporters e.g. Q9X9Z4|SCI5.06C from Streptomyces coelicolor (265 aa),FASTA scores: opt: 893, E(): 4.8e-45, (53.3% identity in 257 aa overlap); Q9L156|SC5C11.16c from Streptomyces coelicolor (279 aa), FASTA scores: opt: 680, E(): 1.3e-32,(45.4% identity in 271 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TXD9	No	cell wall and cell processes							IPR003439,IPR003593,IPR027417	Q7TXD9	A0A1R3Y2X9				Rv3041c		Rv3041c			
NC_002945.3	Mycobrowser_v4	CDS	3363874	3364248	.	-	0	Mb3072c	Mb3072c		conserved protein	Mb3072c, -, len: 124 aa. Equivalent to Rv3046c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Q50171|ML2258 U296W HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa),FASTA scores: opt: 194, E(): 7.6e-06, (35.9% identity in 103 aa overlap); and O06409|Rv0543c|MTCY25D10.22c from Mycobacterium tuberculosis (100 aa), FASTA scores: opt: 192, E(): 1e-05, (34.7% identity in 98 aa overlap).	Q7TXD6	No	conserved hypotheticals							IPR021784	Q7TXD6	A0A1R3Y345				Rv3046c		Rv3046c			
NC_002945.3	Mycobrowser_v4	CDS	3364582	3364866	.	-	0	Mb3073c	Mb3073c		HYPOTHETICAL PROTEIN	Mb3073c, -, len: 94 aa. Equivalent to Rv3047c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Hypothetical unknown protein.	Q7TXD5	No	conserved hypotheticals								Q7TXD5	A0A1R3Y3C6				Rv3047c		Rv3047c			
NC_002945.3	Mycobrowser_v4	CDS	3420520	3420996	.	+	0	Mb3122	Mb3122		HYPOTHETICAL TRANSCRIPTIONAL REGULATORY PROTEIN	Mb3122, -, len: 158 aa. Equivalent to Rv3095, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Possible regulatory protein, because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa),FASTA scores: opt: 486, E(): 1.6e-25, (45.95% identity in 148 aa overlap); Q9AAF6|CC0645 from Caulobacter crescentus (188 aa), FASTA scores: opt: 479, E(): 5.3e-25, (45.75% identity in 153 aa overlap); Q9K408|2SCG61.07 from Streptomyces coelicolor (157 aa), FASTA scores: opt: 407,E(): 2.8e-20, (43.9% identity in 139 aa overlap); etc.	X2BNC8,P0A649	No	regulatory proteins								X2BNC8,P0A649					Rv3095		Rv3095			
NC_002945.3	Mycobrowser_v4	CDS	3366069	3367643	.	-	0	Mb3075c	Mb3075c		PROBABLE MONOOXYGENASE	Mb3075c, -, len: 524 aa. Equivalent to Rv3049c,len: 524 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 524 aa overlap). Probable monooxygenase (EC 1.-.-.-), similar to several monooxygenases e.g. Q9I3H5|PA1538 PROBABLE FLAVIN-CONTAINING MONOOXYGENASE from Pseudomonas aeruginosa (527 aa), FASTA scores: opt: 1577, E(): 3.9e-90, (47.3% identity in 501 aa overlap); Q9RKB5|SCE87.23c MONOOXYGENASE from Streptomyces coelicolor (519 aa), FASTA scores: opt: 1522, E(): 9.8e-87, (47.4% identity in 485 aa overlap); Q9I218|PA2097 PROBABLE FLAVIN-BINDING MONOOXYGENASE from Pseudomonas aeruginosa (491 aa), FASTA scores: opt: 1366, E(): 4.2e-77, (43.75% identity in 489 aa overlap); etc. Also similar to Q10532|Rv0892|Y892_MYCTU|MT0916|MTCY31.20 PROBABLE MONOOXYGENASE (EC 1.14.13.-) from Mycobacterium tuberculosis strain H37Rv (495 aa), FASTA scores: opt: 1147, E(): 1.5e-63, (38.0% identity in 479 aa overlap).	Q7TXD3	No	intermediary metabolism and respiration								Q7TXD3	A0A1R3Y300				Rv3049c		Rv3049c			
NC_002945.3	Mycobrowser_v4	CDS	3367777	3368517	.	-	0	Mb3076c	Mb3076c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY)	Mb3076c, -, len: 246 aa. Equivalent to Rv3050c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Probable transcriptional regulatory protein tetR-family, equivalent but shorter to Q9CBQ1|ML1733 from Mycobacterium leprae (275 aa), FASTA scores: opt: 1381,(E): 2.7e-79, (86.25% identity in 240 aa overlap); AAK44712|MT0489 from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 328,(E): 1.8e-13, (30.75% identity in 234 aa overlap); etc. Also some similarity to O53757|Rv0472c|MTV038.16c. Alternative starts possible at 68052 or 67923. Has potential helix-turn-helix motif at positons 51-72.	Q7TXD2	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TXD2	A0A1R3Y2Z4				Rv3050c		Rv3050c			
NC_002945.3	Mycobrowser_v4	CDS	3677186	3678031	.	-	0	Mb3366c	Mb3366c		HYPOTHETICAL PROLINE RICH PROTEIN	Mb3366c, -, len: 281 aa. Equivalent to Rv3333c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Hypothetical unknown pro-rich protein. Equivalent to AAK47780 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa) but longer 16 aa.	Q7TWP5	No	conserved hypotheticals							IPR007969	Q7TWP5	A0A1R3Y5M9				Rv3333c		Rv3333c			
NC_002945.3	Mycobrowser_v4	CDS	3371981	3372535	.	-	0	Mb3080c	Mb3080c		CONSERVED HYPOTHETICAL PROTEIN	Mb3080c, -, len: 184 aa. Equivalent to Rv3054c,len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Conserved hypothetical protein, similar to Q9RD22|SCM1.21 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (187 aa),FASTA scores: opt: 651, E(): 1.5e-33, (56.8% identity in 175 aa overlap). Also shares similarity with other hypothetical proteins and Chromate reductases e.g. AAK56853|CHRR from Pseudomonas putida (186 aa), FASTA scores: opt: 339, E(): 3.3e-14, (38.75% identity in 160 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599) near C-terminus.	Q7TXD0	No	conserved hypotheticals							IPR005025	Q7TXD0	A0A1R3Y4W7				Rv3054c		Rv3054c			
NC_002945.3	Mycobrowser_v4	CDS	3374345	3375208	.	-	0	Mb3083c	Mb3083c		PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	Mb3083c, -, len: 287 aa. Equivalent to Rv3057c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). Probable oxidoreductase, probably short-chain alcohol dehydrogenase/reductase (EC 1.1.-.-). Equivalent to Q9CBP7|ML1740 POSSIBLE SHORT CHAIN DEHYDROGENASES/REDUCTASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 1563, E(): 6e-89, (81.8% identity in 280 aa overlap). Also similar to many oxidoreductases e.g. Q9ZBX8|SCD78.21c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (585 aa), FASTA scores: opt: 541,E(): 6.7e-26, (37.25% identity in 263 aa overlap); AAK47506|MT3170 OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY from Mycobacterium tuberculosis strain CDC1551 (276 aa), FASTA scores: opt: 521, E(): 6.1e-25, (36.25% identity in 276 aa overlap); AAK45541|MT1283 OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY from Mycobacterium tuberculosis strain CDC1551 (276 aa), FASTA scores: opt: 471, E(): 7.2e-22, (32.4% identity in 281 aa overlap). Also similar to O50460|Rv1245c|MTV006.17C DEHYDROGENASE (276 aa). Contains short-chain alcohol dehydrogenase family signature (PS00061). MAY BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TXC8	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904	Q7TXC8	A0A1R3Y3D4				Rv3057c		Rv3057c			
NC_002945.3	Mycobrowser_v4	CDS	3375272	3375922	.	-	0	Mb3084c	Mb3084c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3084c, -, len: 216 aa. Equivalent to Rv3058c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Possible transcriptional regulatory protein, tetR-family, showing reasonable similarity to others e.g. AAK48337|MT3970 from Mycobacterium tuberculosis strain CDC1551 (216 aa), FASTA scores: opt: 261, E(): 2.8e-10, (31.7% identity in 221 aa overlap); Q49962|ML1070|U1756B from Mycobacterium leprae (217 aa), FASTA scores: opt: 234, E(): 1.8e-08, (27.2% identity in 195 aa overlap); Q9CDD3|ML0064 from Mycobacterium leprae (214 aa), FASTA scores: opt: 199,E(): 3.6e-06, (25.65% identity in 195 aa overlap); O66121|CPRS from Streptomyces coelicolor (215 aa), FASTA scores: opt: 183, E(): 4.2e-05, (26.0% identity in 196 aa overlap). Equivalent to AAK47476|MT3144 from Mycobacterium tuberculosis strain CDC1551 (237 aa) but N-terminus shorter 21 residues. Start was predicted by TBparse but alternatives (ATG) are possible. COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TXC7	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TXC7	A0A1R3Y2Z1				Rv3058c		Rv3058c			
NC_002945.3	Mycobrowser_v4	CDS	3378287	3379759	.	-	0	Mb3086c	Mb3086c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY)	Mb3086c, -, len: 490 aa. Equivalent to Rv3060c,len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 490 aa overlap). Probable transcriptional regulatory protein, showing reasonable similarity to several members of the GntR family e.g. BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 274, E(): 3.5e-10, (30.35% identity in 224 aa overlap); P96570|ESMR from Burkholderia cepacia (Pseudomonas cepacia) (277 aa), FASTA scores: opt: 229, E(): 2.8e-07, (25.85% identity in 240 aa overlap); Q9S276|SCI28.07 from Streptomyces coelicolor (230 aa),FASTA scores: opt: 211, E(): 3.4e-06, (27.25% identity in 220 aa overlap); etc. Seems to have two domains: residues 1-260 resemble UxuR, and 260-490 resemble PdhR, ExuR, etc. Contains bacterial regulatory proteins, GntR family signature (PS00043). Helix-turn-helix motif (+3.13 SD) at aa 38-59. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TXC5	No	regulatory proteins							IPR000524,IPR008920,IPR011711,IPR011991	Q7TXC5	A0A1R3Y304				Rv3060c		Rv3060c			
NC_002945.3	Mycobrowser_v4	CDS	3386372	3386797	.	-	0	Mb3091c	Mb3091c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3091c, -, len: 141 aa. Equivalent to Rv3064c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Probable conserved integral membrane protein, similar to many e.g. Q9KY40|SCC8A.08 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 391,E(): 2.4e-18, (48.45% identity in 130 aa overlap); Q9K461|SC2H12.23c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 339,E(): 5.1e-15, (46.7% identity in 124 aa overlap); BAB48975|MLR1652 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (130 aa), FASTA scores: opt: 319,E(): 8.7e-14, (41.45% identity in 123 aa overlap); Q9JR31|NMA2196|NMB0291 CONSERVED HYPOTHETICAL INNER MEMBRANE PROTEIN from Neisseria meningitidis serogroup A and B (132 aa), FASTA scores: opt: 303, E(): 9.4e-13,(43.65% identity in 126 aa overlap); etc.	Q7TXC1	No	cell wall and cell processes							IPR011637	Q7TXC1	A0A1R3Y3R9				Rv3064c		Rv3064c			
NC_002945.3	Mycobrowser_v4	CDS	3387254	3387862	.	+	0	Mb3093	Mb3093		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)	Mb3093, -, len: 202 aa. Equivalent to Rv3066, len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Probable transcriptional regulatory protein deoR-family, with some similarity to transcriptional regulators and hypothetical proteins, e.g. Q9X9V5|SCI7.35c HYPOTHETICAL 21.1 KDA PROTEIN from Streptomyces coelicolor (197 aa), FASTA scores: opt: 398, E(): 5.7e-19, (40.3% identity in 191 aa overlap); AAG55222|Z1073 PUTATIVE DEOR-TYPE TRANSCRIPTIONAL REGULATOR from Escherichia coli strain O157:H7 EDL933 (178 aa), FASTA scores: opt: 257, E(): 7.9e-10, (28.4% identity in 176 aa overlap); Q9HXU1|PA3699 PROBABLE TRANSCRIPTIONAL REGULATOR (TETR/ACRR FAMILY) from Pseudomonas aeruginosa (237 aa), FASTA scores: opt: 229,E(): 6.7e-08, (32.1% identity in 187 aa overlap); etc.	Q7TXC0	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TXC0	A0A1R3Y3E4				Rv3066		Rv3066			
NC_002945.3	Mycobrowser_v4	CDS	3390239	3390637	.	+	0	Mb3096	Mb3096		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3096, -, len: 132 aa. Equivalent to Rv3069, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Probable conserved transmembrane protein, similar to several hypothetical and CRCB bacterial proteins e.g. Q9A6V2|CC1981 CRCB PROTEIN (see citation below; seems to be involved in camphor resistance and chromosome condensation, promoting or protecting chromosome folding) from Caulobacter crescentus (127 aa), FASTA scores: opt: 275, E(): 1.6e-11, (41.1% identity in 124 aa overlap); Q9FC39|SC4G1.10 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 258, E(): 2.5e-10, (42.15% identity in 121 aa overlap); Q9V0X2|PAB1925 CRCB PROTEIN (see citation below) from Pyrococcus abyssi (123 aa),FASTA scores: opt: 256, E(): 2.8e-10, (39.8% identity in 113 aa overlap); O59171|PH1502 HYPOTHETICAL 13.6 KDA PROTEIN from Pyrococcus horikoshii (123 aa), FASTA scores: opt: 249, E(): 8.2e-10, (38.65% identity in 119 aa overlap); etc.	X2BMZ5,P63863	No	cell wall and cell processes								X2BMZ5,P63863	P63863				Rv3069		Rv3069			
NC_002945.3	Mycobrowser_v4	CDS	3390634	3391014	.	+	0	Mb3097	Mb3097		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3097, -, len: 126 aa. Equivalent to Rv3070, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Probable conserved integral membrane protein, similar to several hypothetical and CRCB bacterial proteins e.g. Q9FC37|SC4G1.12 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (124 aa), FASTA scores: opt: 280, E(): 3.1e-11, (45.3% identity in 117 aa overlap); O25823|HP1225 CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Helicobacter pylori (Campylobacter pylori) (130 aa), FASTA scores: opt: 225, E(): 1e-07, (33.35% identity in 123 aa overlap); O07590|YHDU HYPOTHETICAL 12.4 KDA PROTEIN from Bacillus subtilis (118 aa), FASTA scores: opt: 224, E(): 1.1e-07,(37.85% identity in 111 aa overlap); Q9KVS9|VC0060 CRCB PROTEIN (see citation below; seems involved in camphor resistance and chromosome condensation, promoting or protecting chromosome folding) from Vibrio cholera (126 aa), FASTA scores: opt: 221, E(): 1.8e-07, (33.35% identity in 126 aa overlap); etc.	X2BN96,P63865	No	cell wall and cell processes								X2BN96,P63865	P63865				Rv3070		Rv3070			
NC_002945.3	Mycobrowser_v4	CDS	3391011	3392120	.	+	0	Mb3098	Mb3098		CONSERVED HYPOTHETICAL PROTEIN	Mb3098, -, len: 369 aa. Equivalent to Rv3071, len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Conserved hypothetical protein, weakly similar in N-terminus of Q9A4V0|CC2725 HYPOTHETICAL PROTEIN CC2725 from Caulobacter crescentus (113 aa), FASTA scores: opt: 141, E(): 0.031,(27.6% identity in 105 aa overlap). C-terminal region also weakly similar to other hypothetical proteins e.g. Q9FC38|YG11_STRCO from Streptomyces coelicolor (114 aa),FASTA scores: opt: 151, E(): 0.007, (31.65% identity in 98 aa overlap).	Q7TXB7	No	conserved hypotheticals							IPR003793,IPR011322,IPR015867	Q7TXB7	A0A1R3Y317				Rv3071		Rv3071			
NC_002945.3	Mycobrowser_v4	CDS	3396088	3397899	.	+	0	Mb3104	Mb3104		POSSIBLE HYDROLASE	Mb3104, -, len: 603 aa. Equivalent to Rv3077, len: 603 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 603 aa overlap). Possible hydrolase (EC 3.1.-.-), with some similarity to variety of hydrolases (aryl- and steryl sulfatases principaly) e.g. Q45087|PEHA PHOSPHONATE MONOESTER HYDROLASE from Burkholderia caryophylli (514 aa), FASTA scores: opt: 239, E(): 7.2e-07, (23.95% identity in 413 aa overlap); Q9I1E5|PA2333 PROBABLE SULFATASE from Pseudomonas aeruginosa (538 aa), FASTA scores: opt: 231, E(): 2.3e-06,(28.1% identity in 516 aa overlap); P31447|YIDJ_ECOLI|B3678 PUTATIVE SULFATASE (EC 3.1.6.-) from Escherichia coli (497 aa), FASTA scores: opt: 222,E(): 7.4e-06, (27.7% identity in 390 aa overlap); etc. Note that previously known as atsF.	Q7TXB2	No	intermediary metabolism and respiration							IPR000917,IPR017849,IPR017850	Q7TXB2	A0A1R3Y312				Rv3077		Rv3077			
NC_002945.3	Mycobrowser_v4	CDS	3392876	3393232	.	-	0	Mb3100c	Mb3100c		CONSERVED HYPOTHETICAL PROTEIN	Mb3100c, -, len: 118 aa. Equivalent to Rv3073c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein, highly similar to other e.g. Q9F3D7|SC2H2.18 from Streptomyces coelicolor (119 aa),FASTA scores: opt: 399, E(): 2.5e-20, (53.05% identity in 115 aa overlap); Q9K4K9|SC5F8.15c from Streptomyces coelicolor (117 aa), FASTA scores: opt: 334, E(): 6e-16,(49.1% identity in 112 aa overlap); Q9HKD5|TA0666 from Thermoplasma acidophilum (134 aa), FASTA scores: opt: 334,E(): 6.7e-16, (42.35% identity in 111 aa overlap); BAB53507|MLL7394 from Rhizobium loti (Mesorhizobium loti) (120 aa), FASTA scores: opt: 309, E(): 3e-14, (43.65% identity in 110 aa overlap); etc.	X2BMJ4	No	conserved hypotheticals								X2BMJ4					Rv3073c		Rv3073c			
NC_002945.3	Mycobrowser_v4	CDS	3393326	3394600	.	+	0	Mb3101	Mb3101		CONSERVED HYPOTHETICAL PROTEIN	Mb3101, -, len: 424 aa. Equivalent to Rv3074, len: 424 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 424 aa overlap). Conserved hypothetical protein, highly similar but shorter (46 aa) to P71806|Rv1378c|MTCY02B12.12c HYPOTHETICAL 51.3 KDA PROTEIN from Mycobacterium tuberculosis (475 aa), FASTA scores: opt: 2009, E(): 5.8e-113, (72.95% identity in 429 aa overlap); and also similar to other hypothetical mycobacterium proteins e.g. O33266|Rv0336|MTCY279.03 (503 aa), FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); O33360|Rv0515|MTCY20G10.05 (503 aa),FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); etc.	Q7TXB5	No	conserved hypotheticals							IPR003615,IPR003870	Q7TXB5					Rv3074		Rv3074			
NC_002945.3	Mycobrowser_v4	CDS	3394597	3395520	.	-	0	Mb3102c	Mb3102c		conserved protein	Mb3102c, -, len: 307 aa. Equivalent to Rv3075c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). Conserved hypopthetical protein, with some similarity to Q9I562|PA0883 PROBABLE ACYL-COA LYASE BETA CHAIN from Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 408,E(): 9.2e-19, (35.15% identity in 273 aa overlap); Q9S2U9|SC4G6.02 PUTATIVE CITRATE LYASE BETA CHAIN from Streptomyces coelicolor (274 aa), FASTA scores: opt: 384,E(): 3.1e-17, (34.7% identity in 265 aa overlap); O06162|CITE|Rv2498c|MTCY07A7.04c from Mycobacterium tuberculosis (273 aa), FASTA scores: opt: 349, E(): 5.1e-15, (35.2% identity in 264 aa overlap); etc. Several initiation codons possible, first one chosen.	Q7TXB4	No	conserved hypotheticals							IPR005000,IPR011206,IPR015813	Q7TXB4					Rv3075c		Rv3075c			
NC_002945.3	Mycobrowser_v4	CDS	3398317	3399144	.	-	0	Mb3106c	Mb3106c		conserved protein	Mb3106c, -, len: 275 aa. Equivalent to Rv3079c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Conserved hypothetical protein, similar to other hypothetical mycobacterium proteins e.g. P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 POSSIBLE OXIDOREDUCTASE from Mycobacterium tuberculosis strain H37Rv (282 aa), FASTA scores: opt: 668, E(): 2.4e-34,(40.55% identity in 281 aa overlap); O06216|Rv2161c|MTCY270.07 from M. tuberculosis strain H37Rv (288 aa), FASTA scores: opt: 595, E(): 8.5e-30,(40.9% identity in 274 aa overlap); O87779 from Mycobacterium paratuberculosis (166 aa), FASTA scores: opt: 464, E(): 7.2e-22, (41.55% identity in 166 aa overlap); etc. Also some similarity to other proteins e.g. Q9AH10 PUTATIVE F420-DEPENDENT DEHYDROGENASE from Rhodococcus erythropolis (295 aa), FASTA scores: opt: 401,E(): 9.6e-18, (30.2% identity in 288 aa overlap); Q9AE04|RIF17 RIF17 PROTEIN from Amycolatopsis mediterranei (356 aa), FASTA scores: opt: 298, E(): 2.8e-11, (35.0% identity in 203 aa overlap); AAK48081|MT3720 LUCIFERASE-RELATED PROTEIN from Mycobacterium tuberculosis strain CDC1551 (395 aa), FASTA scores: opt: 223, E(): 1.4e-06, (29.4% identity in 211 aa overlap).	Q7TXB0	No	conserved hypotheticals							IPR011251,IPR019921	Q7TXB0					Rv3079c		Rv3079c			
NC_002945.3	Mycobrowser_v4	CDS	3418307	3419311	.	-	0	Mb3120c	Mb3120c		HYPOTHETICAL OXIDOREDUCTASE	Mb3120c, -, len: 334 aa. Equivalent to Rv3093c,len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 334 aa overlap). Hypothetical oxidoreductase (EC 1.-.-.-), with some similarity with various oxidoreductases e.g. Q58929|MER|MJ1534 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 300, E(): 1.1e-10, (24.1% identity in 324 aa overlap); and Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa),FASTA scores: opt: 264, E(): 1.5e-08, (30.45% identity in 335 aa overlap); Q9CCV8|ML0348 POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE from Mycobacterium leprae (350 aa), FASTA scores: opt: 220, E(): 6.4e-06, (26.5% identity in 328 aa overlap); etc.	Q7TX97	No	intermediary metabolism and respiration							IPR011251,IPR022526	Q7TX97					Rv3093c		Rv3093c			
NC_002945.3	Mycobrowser_v4	CDS	3721748	3722119	.	-	0	Mb3387c	Mb3387c		POSSIBLE OXIDOREDUCTASE	Mb3387c, -, len: 123 aa. Equivalent to Rv3352c,len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 123 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to part of several oxidoreductases (and hypothetical proteins) from diverse organisms e.g. Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 348, E(): 7.9e-15, (51.0% identity in 102 aa overlap); BAB53081|MLR6875 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (479 aa), FASTA scores: opt: 262, E(): 2.3e-09, (53.85% identity in 78 aa overlap); O94206|OX1 OXIDOREDUCTASE from Claviceps purpurea (Ergot fungus) (483 aa), FASTA scores: opt: 245,E(): 2.7e-08, (42.6% identity in 115 aa overlap); Q9KHK2|ENCM PUTATIVE FAD-DEPENDENT OXYGENASE ENCM from Streptomyces maritimus (464 aa), FASTA scores: opt: 238,E(): 7.2e-08, (43.95% identity in 91 aa overlap); etc. Also highly similar to part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE (479 aa), FASTA scores: opt: 599, E(): 1.6e-30, (71.55% identity in 123 aa overlap); and to other Mycobacterium tuberculosis proteins e.g. Rv3353c and Rv3351c. All show similarity to a family of oxidoreductases in M. tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found.	Q7TWN4	No	intermediary metabolism and respiration							IPR006094,IPR016166,IPR016169	Q7TWN4					Rv3352c		Rv3352c			
NC_002945.3	Mycobrowser_v4	CDS	3402587	3403825	.	+	0	Mb3108	Mb3108		CONSERVED HYPOTHETICAL PROTEIN	Mb3108, -, len: 412 aa. Equivalent to Rv3081, len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 412 aa overlap). Conserved hypothetical protein. Second part of the protein (approximatively residues 250-412) shares weak similarity with other hypothetical proteins e.g. Q9YEU3|APE0488 from Aeropyrum pernix (188 aa), FASTA scores: opt: 149, E(): 0.019, E(): 0.019, (29.5% identity in 173 aa overlap); and first part shares weak similarity with C-terminal part of Q9RVT9|DR0933 ALPHA-AMLYASE from Deinococcus radiodurans (644 aa), FASTA scores: opt: 127, E(): 1.4, (27.25% identity in 198 aa overlap). Equivalent to AAK47502|MT3166 HYPOTHETICAL 48.3 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (436 aa) but shorter 24 aa in N-terminus. Contains PS00850 Glycine radical signature and possible helix-turn-helix motif at aa 53-74.	Q7TXA8	No	conserved hypotheticals							IPR018700	Q7TXA8					Rv3081		Rv3081			
NC_002945.3	Mycobrowser_v4	CDS	3405051	3406538	.	+	0	Mb3110	Mb3110		PROBABLE MONOOXYGENASE (HYDROXYLASE)	Mb3110, -, len: 495 aa. Equivalent to Rv3083, len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Probable monooxygenase (EC 1.-.-.-), highly similar to other putative monooxygenases flavin-binding family e.g. AAK48336|MT3969 from Mycobacterium tuberculosis strain CDC1551 (489 aa),FASTA scores: opt: 1692, E(): 4.9e-98, (49.7% identity in 489 aa overlap); Q9A588|CC2569 from Caulobacter crescentus (498 aa), FASTA scores: opt: 1684, E(): 1.6e-97, (52.25% identity in 484 aa overlap); Q9APW3 from Pseudomonas aeruginosa (508 aa), FASTA scores: opt: 1603, E(): 1.8e-92, (49.8% identity in 484 aa overlap); etc.	Q7TXA6	No	intermediary metabolism and respiration								Q7TXA6					Rv3083		Rv3083			
NC_002945.3	Mycobrowser_v4	CDS	3407467	3408297	.	+	0	Mb3112	Mb3112		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb3112, -, len: 276 aa. Equivalent to Rv3085, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various oxidoreductases in the short chain dehydrogenases/reductases family e.g. Q9CC98|ML1094 SHORT CHAIN ALCOHOL DEHYDROGENASE from Mycobacterium leprae (277 aa), FASTA scores: opt: 1059, E(): 4.8e-56, (61.65% identity in 266 aa overlap); Q9I3H6|PA1537 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginos (295 aa), FASTA scores: opt: 858, E(): 4.7e-44, (48.4% identity in 285 aa overlap); Q9CBP7|ML1740 POSSIBLE SHORT CHAIN REDUCTASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 500, E(): 1e-22, (36.6% identity in 257 aa overlap); etc. Also similar to mycobacterium proteins O50460|Rv1245c|MTV006.17c DEHYDROGENASE SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (276 aa),FASTA scores: opt: 1200, E(): 1.9e-64, (65.2% identity in 273 aa overlap); and P95101|Rv3057c|MTCY22D7.24 HYPOTHETICAL DEHYDROGENASE (287 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TXA4	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904	Q7TXA4					Rv3085		Rv3085			
NC_002945.3	Mycobrowser_v4	CDS	3409472	3410890	.	+	0	Mb3114	Mb3114		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb3114, -, len: 472 aa. Equivalent to Rv3087, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 472 aa overlap). Hypothetical protein,similar to several Mycobacterium tuberculosis proteins e.g. MTCY08D5.16, MTCY28.26, MTCY493.29c. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa).	Q7TXA2	No	lipid metabolism							IPR004255,IPR014292	Q7TXA2					Rv3087		Rv3087			
NC_002945.3	Mycobrowser_v4	CDS	1355490	1355717	.	+	0	Mb1243	Mb1243		conserved protein	Mb1243, -, len: 75 aa. Equivalent to Rv1211, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Conserved hypothetical protein, similar to Q49958|U1756N Mycobacterium leprae (75 aa), FASTA scores: opt: 460, E(): 0, (90.7% identity in 75 aa overlap).	Q7U0D8,A0A1R3XXQ4	No	conserved hypotheticals			A0A1R3XXQ4				IPR021465	Q7U0D8					Rv1211		Rv1211			
NC_002945.3	Mycobrowser_v4	CDS	3417361	3418281	.	-	0	Mb3119c	Mb3119c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3119c, -, len: 306 aa. Equivalent to Rv3092c,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 306 aa overlap). Probable conserved integral membrane protein, highly similar to Q9RUT5|DR1297 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (311 aa), FASTA scores: opt: 941, E(): 9.8e-51, (55.65% identity in 309 aa overlap); Q9A8B8|CC1436 HYPOTHETICAL PROTEIN from Caulobacter crescentus (314 aa), FASTA scores: opt: 791, E(): 1.6e-41,(46.9% identity in 305 aa overlap); and also highly similar to Q9I2N8|PA1857 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (307 aa), FASTA scores: opt: 373,E(): 8.1e-16, (40.8% identity in 321 aa overlap); BAB36119|ECS2696 PUTATIVE METHYL-INDEPENDENT MISMATCH REPAIR PROTEIN from Escherichia coli strain O157:H7 (305 aa), FASTA scores: opt: 335, E(): 1.7e-13, (39.75% identity in 307 aa overlap).	Q7TX98	No	cell wall and cell processes							IPR008526	Q7TX98					Rv3092c		Rv3092c			
NC_002945.3	Mycobrowser_v4	CDS	3447372	3447953	.	-	0	Mb3152c	Mb3152c		CONSERVED HYPOTHETICAL PROTEIN	Mb3152c, -, len: 193 aa. Equivalent to 5' end of Rv3128c, len: 337 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 193 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon but is similar throughout its length to Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 954, E(): 0, (47.2% identity in 339 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis,Rv3128c is split into 2, Mb3151c and Mb3152c.	Q7TX72	No								IPR001584,IPR012337	Q7TX72										
NC_002945.3	Mycobrowser_v4	CDS	3419308	3420438	.	-	0	Mb3121c	Mb3121c		CONSERVED HYPOTHETICAL PROTEIN	Mb3121c, -, len: 376 aa. Equivalent to Rv3094c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Conserved hypothetical protein, some similarity with various proteins e.g. Q9RMR9|NRGC NRGC PROTEIN (corresponding gene seems regulated by NifA) from Bradyrhizobium japonicum (388 aa), FASTA scores: opt: 677, E(): 5.8e-35, (34.55% identity in 353 aa overlap); P26698|PIGM_RHOSO PIGMENT PROTEIN from Rhodococcus sp. strain ATCC 21145 (387 aa),FASTA scores: opt: 480, E(): 1.2e-22, (28.7% identity in 376 aa overlap); Q9F0J3|NCNH HYDROXYLASE from Streptomyces arenae (405 aa), FASTA scores: opt: 441, E(): 3.3e-20,(29.25% identity in 352 aa overlap); etc. Equivalent to AAK47516 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but N-terminus shorter 19 aa.	Q7TX96	No	conserved hypotheticals							IPR006091,IPR009075,IPR009100,IPR013107,IPR013786	Q7TX96					Rv3094c		Rv3094c			
NC_002945.3	Mycobrowser_v4	CDS	3421094	3422233	.	+	0	Mb3123	Mb3123		CONSERVED HYPOTHETICAL PROTEIN	Mb3123, -, len: 379 aa. Equivalent to Rv3096, len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 379 aa overlap). Hypothetical protein,with slight similarity to several proteins e.g. Q09671|OYEB_SCHPO|SPAC5H10.10 PUTATIVE NADPH DEHYDROGENASE C5H10.10 (EC 1.6.99.1) (OLD YELLOW ENZYME HOMOLOG) from Schizosaccharomyces pombe (Fission yeast) (392 aa), FASTA scores: opt: 125, E(): 1.1, (25.45% identity in 165 aa overlap); and Q12603|XYNA_DICTH BETA-1,4-XYLANASE (EC 3.2.1.8) (ENDO-1,4-BETA-XYLANASE) from Dictyoglomus thermophilum (352 aa), FASTA scores: opt: 124, E(): 1.2,(25.65% identity in 195 aa overlap); etc. Contains glycosyl hydrolases family 5 signature (PS00659). TBparse score is 0.932.	Q7TX95	No	conserved hypotheticals							IPR013781,IPR017853,IPR024778	Q7TX95					Rv3096		Rv3096			
NC_002945.3	Mycobrowser_v4	CDS	3464227	3464655	.	-	0	Mb3166c	Mb3166c		HYPOTHETICAL PROTEIN	Mb3166c, -, len: 142 aa. Equivalent to Rv3142c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Hypothetical unknown protein. Equivalent to AAK47569 from Mycobacterium tuberculosis strain CDC1551 but shorter 33 aa.	Q7TX60	No	conserved hypotheticals								Q7TX60					Rv3142c		Rv3142c			
NC_002945.3	Mycobrowser_v4	CDS	3448432	3448764	.	+	0	Mb3153	Mb3153		CONSERVED HYPOTHETICAL PROTEIN	Mb3153, -, len: 110 aa. Equivalent to Rv3129, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Conserved hypothetical protein, with some similarity to various hypothetical proteins from Streptomyces coelicolor e.g. Q9RI34|SCJ12.26 HYPOTHETICAL 14.5 KDA PROTEIN (137 aa),FASTA scores: opt: 141, E(): 0.0016, (39.3% identity in 84 aa overlap); Q9RI49|SCJ12.09c HYPOTHETICAL 15.8 KDA PROTEIN (146 aa), FASTA scores: opt: 141, E(): 0.0017,(38.05% identity in 92 aa overlap); Q9RJ05|SCJ1.09C POSSIBLE DNA-BINDING PROTEIN (233 aa), FASTA scores: opt: 140, E(): 0.0029, (34.85% identity in 89 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT (334 aa); etc.	Q7TX71	No	conserved hypotheticals							IPR012349,IPR024747	Q7TX71					Rv3129		Rv3129			
NC_002945.3	Mycobrowser_v4	CDS	3428399	3429325	.	-	0	Mb3131c	Mb3131c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3131c, -, len: 308 aa. Equivalent to Rv3104c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Possible conserved transmembrane protein, with some similarity to hypthetical proteins e.g. Q9L1X9|SC8E4A.26 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (408 aa), FASTA scores: opt: 514, E(): 4.3e-25, (35.2% identity in 287 aa overlap); Q9XA89|CF43A.26c HYPOTHETICAL 36.1 KDA PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 482,E(): 3.7e-23, (34.9% identity in 301 aa overlap); Q55987|SLR0765 HYPOTHETICAL 68.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (617 aa), FASTA scores: opt: 429, E(): 1.3e-19, (30.6% identity in 278 aa overlap); etc.	Q7TX88	No	cell wall and cell processes							IPR006685,IPR010920,IPR011014,IPR011066	Q7TX88					Rv3104c		Rv3104c			
NC_002945.3	Mycobrowser_v4	CDS	3446940	3447290	.	-	0	Mb3151c	Mb3151c		CONSERVED HYPOTHETICAL PROTEIN	Mb3151c, -, len: 116 aa. Equivalent to 3' end of Rv3128c, len: 337 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 116 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon but is similar throughout its length to Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 954, E(): 0, (47.2% identity in 339 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis,Rv3128c is split into 2, Mb3151c and Mb3152c.	Q7TX73	No									Q7TX73	A0A1R3Y3C7									
NC_002945.3	Mycobrowser_v4	CDS	3464763	3465164	.	+	0	Mb3167	Mb3167		PROBABLE RESPONSE REGULATOR	Mb3167, -, len: 133 aa. Equivalent to Rv3143, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable response regulator, similar to other sensory transduction regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor (133 aa), FASTA scores: opt: 474,E(): 2.8e-24, (54.15% identity in 120 aa overlap); Q9KZ82|SCE25.04c from Streptomyces coelicolor (225 aa),FASTA scores: opt: 144, E(): 0.016, (32.3% identity in 127 aa overlap); Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa), FASTA scores: opt: 145, E(): 0.024, (30.65% identity in 124 aa overlap). SIMILAR TO OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS.	Q7TX59	No	regulatory proteins							IPR001789,IPR011006	Q7TX59					Rv3143		Rv3143			
NC_002945.3	Mycobrowser_v4	CDS	3506504	3506938	.	-	0	Mb3206c	Mb3206c		HYPOTHETICAL ALANINE RICH PROTEIN	Mb3206c, -, len: 144 aa. Equivalent to Rv3180c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Hypothetical unknown ala-rich protein. Contains probable coiled-coil domain from aa 40 to 70.	Q7TX31	No	conserved hypotheticals							IPR002716,IPR022907	Q7TX31	A0A1R3Y3C5				Rv3180c		Rv3180c			
NC_002945.3	Mycobrowser_v4	CDS	3436621	3437289	.	+	0	Mb3140	Mb3140		POSSIBLE PHOSPHATASE	Mb3140, -, len: 222 aa. Equivalent to Rv3113, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 222 aa overlap). Possible phosphatase (EC 3.1.3.-), with weak similarity to other phosphatases e.g. Q9KYY0|SCE33.02c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 368, E(): 1.2e-16, (32.9% identity in 222 aa overlap); and Q55039|GPH_SYNP7|CBBZ PHOSPHOGLYCOLATE PHOSPHATASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (212 aa), FASTA scores: opt: 176, E(): 0.00025, (24.7% identity in 182 aa overlap).	Q7TX83	No	intermediary metabolism and respiration							IPR006439,IPR023214	Q7TX83	A0A1R3Y3V3				Rv3113		Rv3113			
NC_002945.3	Mycobrowser_v4	CDS	3437306	3437836	.	+	0	Mb3141	Mb3141		CONSERVED HYPOTHETICAL PROTEIN	Mb3141, -, len: 176 aa. Equivalent to Rv3114, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 176 aa overlap). Conserved hypothetical protein, with some similarity to Q9F9W7 CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa), FASTA scores: opt: 207, E(): 2.2e-07, (37.05% identity in 108 aa overlap); and Q9RV23|DR1207 CELL CYCLE PROTEIN MESJ,PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN from Deinococcus radiodurans (600 aa), FASTA scores: opt: 212,E(): 3.5e-07, (33.35% identity in 177 aa overlap). Equivalent to AAK47536|MT3196 CYTIDINE AND DEOXYCYTIDYLATE DEAMINASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (187 aa) but shorter 11 aa.	Q7TX82	No	conserved hypotheticals							IPR002125,IPR016193	Q7TX82	A0A1R3Y3B1				Rv3114		Rv3114			
NC_002945.3	Mycobrowser_v4	CDS	3445919	3446953	.	+	0	Mb3150	Mb3150		conserved protein	Mb3150, -, len: 344 aa. Equivalent to Rv3127, len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 344 aa overlap). Hypothetical protein,highly similar to Mycobacterium tuberculosis protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 1212,E(): 6e-69, (56.7% identity in 321 aa overlap), and also similar to P95195|MTCY03A2.27c (332 aa), FASTA scores: opt: 521, E(): 1.6e-25; (35.0% identity in 326 aa overlap). Some similarity to C-terminal half of hypothetical Mycobacterium tuberculosis proteins.	Q7TX74	No	conserved hypotheticals							IPR000415	Q7TX74	A0A1R3Y3W2				Rv3127		Rv3127			
NC_002945.3	Mycobrowser_v4	CDS	3450323	3451321	.	+	0	Mb3155	Mb3155		conserved protein	Mb3155, -, len: 332 aa. Equivalent to Rv3131, len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 332 aa overlap). Hypothetical protein,similar to other hypothetical bacterial proteins e.g. O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 568,E(): 2.5e-27, (36.7% identity in 321 aa overlap); O05800|Rv3127|MTCY164.37 (344 aa), FASTA scores: opt: 521,E(): 1.9e-24, (34.95% identity in 326 aa overlap); Q9RI33|SCJ12.27c from Streptomyces coelicolor (335 aa),FASTA scores: opt: 441, E(): 1.3e-19, (35.75% identity in 319 aa overlap); Q9RI44|SCJ12.14 from Streptomyces coelicolor (309 aa), FASTA scores: opt: 328, E(): 9.3e-13,(27.9% identity in 308 aa overlap); Q9CBP5|ML1751 from Mycobacterium leprae (721 aa), FASTA scores: opt: 137,E(): 0.78, (26.15% identity in 298 aa overlap); etc. Equivalent to AAK47555 from Mycobacterium tuberculosis strain CDC1551 but shorter 12 aa.	Q7TX70	No	conserved hypotheticals							IPR000415	Q7TX70	A0A1R3Y371				Rv3131		Rv3131			
NC_002945.3	Mycobrowser_v4	CDS	3764056	3764682	.	+	0	Mb3428	Mb3428		PROBABLE MEMBRANE PROTEIN	Mb3428, -, len: 208 aa. Equivalent to Rv3395A, len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Probable membrane protein, with potential transmembrane stretches from aa 7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 107, E(): 7.4, (34.05% identity in 94 aa overlap).	Q7TWJ8	No	cell wall and cell processes								Q7TWJ8	A0A1R3Y423				Rv3395A		Rv3395A			
NC_002945.3	Mycobrowser_v4	CDS	3453715	3454521	.	-	0	Mb3158c	Mb3158c		universal stress protein family protein	Mb3158c, -, len: 268 aa. Equivalent to Rv3134c,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Conserved Ala-,Val-rich protein (see citations below), related to other hypothetical Mycobacterium tuberculosis proteins e.g. O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 562, E(): 3.2e-28, (40.65% identity in 273 aa overlap); O06188|Rv2624c|MTCY01A10.08 (272 aa), FASTA scores: opt: 458, E(): 1.1e-21, (36.55% identity in 271 aa overlap); O53472|R2026c|MTV018.13c (294 aa), FASTA scores: opt: 232,E(): 1.9e-07, (30.45% identity in 276 aa overlap); etc. Shares some similarity with other hypothetical proteins from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c (294 aa), FASTA scores: opt: 207, E(): 6.9e-06, (28.9% identity in 263 aa overlap); Q9K4L5|SC5F8.09 PUTATIVE STRESS-INDUCIBLE PROTEIN (312 aa), FASTA scores: opt: 204,E(): 1.1e-05, (28.4% identity in 271 aa overlap); etc. Equivalent to AAK47558|MT3220 Universal stress protein family from Mycobacterium tuberculosis strain CDC1551 (268 aa). Rv3134c seems cotranscribed with devR-devS (see second citation below).	Q7TX68	No	virulence, detoxification, adaptation							IPR006015,IPR006016,IPR014729	Q7TX68	A0A1R3Y386				Rv3134c		Rv3134c			
NC_002945.3	Mycobrowser_v4	CDS	3458502	3459284	.	+	0	Mb3161	Mb3161		PROBABLE MONOPHOSPHATASE	Mb3161, -, len: 260 aa. Equivalent to Rv3137, len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 260 aa overlap). Probable monophosphatase (EC 3.1.3.-), equivalent to O32889|MLCB1779_19|ML0662 PUTATIVE MONOPHOSPHATASE from Mycobacterium leprae (255 aa), FASTA scores: opt: 1403,E(): 1.2e-81, (81.8% identity in 253 aa overlap). Also similar to Q9K4B1|SC7E4.05c from Streptomyces coelicolor (266 aa), FASTA scores: opt: 969, E(): 3.5e-54, (57.9% identity in 259 aa overlap); Q53743|PUR3 MONO-PHOSPHATASE from Streptomyces lipmanii (Streptomyces alboniger) (273 aa), FASTA scores: opt: 862, E(): 2.1e-47, (55.25% identity in 257 aa overlap); BAB50023|MLL3039 MONO-PHOSPHATASE from Rhizobium loti (Mesorhizobium loti) (262 aa), FASTA scores: opt: 448, E(): 3.2e-21, (31.37% identity in 255 aa overlap); etc. Contains inositol monophosphatase family signature 1 (PS00629).	Q7TX65	No	intermediary metabolism and respiration							IPR000760,IPR011809,IPR020583	Q7TX65	A0A1R3Y3K2				Rv3137		Rv3137			
NC_002945.3	Mycobrowser_v4	CDS	3509956	3511221	.	-	0	Mb3212c	Mb3212c		HYPOTHETICAL PROTEIN	Mb3212c, -, len: 421 aa. Equivalent to Rv3190c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 421 aa overlap). Hypothetical unknown protein.	Q7TX25	No	conserved hypotheticals								Q7TX25	A0A1R3Y3C3				Rv3190c		Rv3190c			
NC_002945.3	Mycobrowser_v4	CDS	3506941	3507393	.	-	0	Mb3207c	Mb3207c		conserved protein	Mb3207c, -, len: 150 aa. Equivalent to Rv3181c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 150 aa overlap). Hypothetical protein,with some similarity to other mycobacterium proteins e.g. Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c (99 aa), FASTA scores: opt: 123, E(): 0.25, (33.7% identity in 89 aa overlap); and O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 123, E(): 0.26, (39.7% identity in 68 aa overlap).	Q7TX30	No	conserved hypotheticals							IPR006442	Q7TX30	A0A1R3Y3D1				Rv3181c		Rv3181c			
NC_002945.3	Mycobrowser_v4	CDS	3494489	3495613	.	+	0	Mb3194	Mb3194		conserved protein	Mb3194, -, len: 374 aa. Equivalent to Rv3169, len: 374 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 374 aa overlap). Conserved hypothetical protein, with similarity to other hypothetical proteins: Q9A8W6|CC1232 from Caulobacter crescentus (368 aa), FASTA scores: opt: 669, E(): 3.3e-34,(34.05% identity in 376 aa overlap); and O32901|MLCB1779.41 from Mycobacterium leprae (127 aa),FASTA scores: opt: 179, E(): 0.00034, (29.0% identity in 131 aa overlap). Also weak similarity with P95149|Rv1866|MTCY359.07c (804 aa), FASTA scores: opt: 121, E(): 6.4, (37.0% identity in 119 aa overlap). Equivalent to AAK47597 from Mycobacterium tuberculosis strain CDC1551 but shorter 43 aa.	Q7TX42	No	conserved hypotheticals								Q7TX42	A0A1R3Y3B6				Rv3169		Rv3169			
NC_002945.3	Mycobrowser_v4	CDS	3507624	3507968	.	+	0	Mb3208	Mb3208		CONSERVED HYPOTHETICAL PROTEIN	Mb3208, -, len: 114 aa. Equivalent to Rv3182, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Hypothetical protein,with some similarity to other hypothetical bacterial proteins e.g. O53468|Rv2022c|MTV018.09c from M. tuberculosis (201 aa), FASTA scores: opt: 335, E(): 3.6e-16, (51.9% identity in 104 aa overlap); and Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119 aa),FASTA scores: opt: 250, E(): 1.6e-10, (42.1% identity in 95 aa overlap). Equivalent to AAK47614 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but longer 20 aa.	Q7TX29	No	conserved hypotheticals							IPR009241	Q7TX29	A0A1R3Y560				Rv3182		Rv3182			
NC_002945.3	Mycobrowser_v4	CDS	3511389	3511598	.	+	0	Mb3212A	Mb3212A		Conserved protein	Mb3212A, len: 69 aa. Equivalent to Rv3190A len: 69 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 69 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BMU9	No	conserved hypotheticals								X2BMU9	A0A1R3Y3E0				Rv3190A		Rv3190A			
NC_002945.3	Mycobrowser_v4	CDS	3909099	3910253	.	-	0	Mb3559c	Mb3559c		CONSERVED HYPOTHETICAL PROTEIN	Mb3559c, -, len: 384 aa. Equivalent to Rv3529c,len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 384 aa overlap). Conserved hypothetical protein, showing some similarity to Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 HYPOTHETICAL 46.1 KDA PROTEIN from Mycobacterium tuberculosis (388 aa) FASTA scores: opt: 261, E(): 1.6e-09, (27.25% identity in 253 aa overlap).	Q7TWA2	No	conserved hypotheticals							IPR027417	Q7TWA2	A0A1R3Y526				Rv3529c		Rv3529c			
NC_002945.3	Mycobrowser_v4	CDS	3541385	3542080	.	-	0	Mb3236c	Mb3236c		conserved protein	Mb3236c, -, len: 231 aa. Equivalent to Rv3210c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Conserved hypothetical protein, similar (but N-terminus shorter) to Q9FBJ1|SCP8.30 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (260 aa), FASTA scores: opt: 599,E(): 1.1e-30, (42.5% identity in 233 aa overlap); and some similarity to Q9RRV1|DR2384 PHENYLACETIC ACID DEGRADATION PROTEIN PAAC from Deinococcus radiodurans (263 aa), FASTA scores: opt: 129, E(): 0.43, (27.9% identity in 172 aa overlap); and Q9F621 FLGK PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (472 aa).	Q7TX02	No	conserved hypotheticals							IPR009078,IPR012347	Q7TX02	A0A1R3Y586				Rv3210c		Rv3210c			
NC_002945.3	Mycobrowser_v4	CDS	3486590	3487231	.	-	0	Mb3185c	Mb3185c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3185c, -, len: 213 aa. Equivalent to Rv3160c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR PROTEIN (global repressor in the nitrogen regulation system; see first citation below for more information) (222 aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity in 208 aa overlap); Q9X7X9|SC6A5.33c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (223 aa), FASTA scores: opt: 176,E(): 0.00018, (26.5% identity in 185 aa overlap); Q9XA31|SCH69.03c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (209 aa), FASTA scores: opt: 173,E(): 0.00027, (27.25% identity in 176 aa overlap); BAB54133|MLL7734 TRANSCRIPTIONAL REGULATOR from Rhizobium loti (Mesorhizobium loti) (213 aa), FASTA scores: opt: 172, E(): 0.00031, (23.55% identity in 204 aa overlap); etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis strain H37Rv e.g. P96839|Rv3557v|MTCY06G11.04c (200 aa), FASTA scores: opt: 169, E(): 0.00046, (26.75% identity in 157 aa overlap). Contains probable helix-turn-helix motif from aa 31 to 52 (Score 1857, +5.51 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.901.	Q7TX51	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893,IPR023772	Q7TX51	A0A1R3Y394				Rv3160c		Rv3160c			
NC_002945.3	Mycobrowser_v4	CDS	3487242	3488390	.	-	0	Mb3186c	Mb3186c		POSSIBLE DIOXYGENASE	Mb3186c, -, len: 382 aa. Equivalent to Rv3161c,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 382 aa overlap). Possible dioxygenase (EC 1.-.-.-), similar to subunit of several dioxygenases and related proteins e.g. BAB50510|MLR3662 DIOXYGENASE,ALPHA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (400 aa), FASTA scores: opt: 413, E(): 6.2e-20, (28.4% identity in 331 aa overlap); Q9A3T0|CC3122 RIESKE 2FE-2S FAMILY PROTEIN from Caulobacter crescentus (404 aa), FASTA scores: opt: 405, E(): 2.1e-19, (27.95% identity in 372 aa overlap); Q9HTF4|PA5410 PROBABLE RING HYDROXYLATING DIOXYGENASE, ALPHA-SUBUNIT from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 392, E(): 1.6e-18, (25.8% identity in 399 aa overlap); Q9AGK6|PHTAA PHTHALATE DIOXYGENASE LARGE SUBUNIT from Arthrobacter keyseri (473 aa), FASTA scores: opt: 385, E(): 5.2e-18, (34.0% identity in 206 aa overlap); P76253|YEAW_ECOLI PUTATIVE DIOXYGENASE, ALPHA SUBUNIT from Escherichia coli (374 aa),FASTA scores: opt: 376, E(): 1.7e-17, (27.05% identity in 344 aa overlap); etc. TBparse score is 0.932.	Q7TX50	No	intermediary metabolism and respiration							IPR001663,IPR015879,IPR017941	Q7TX50	A0A1R3Y3A6				Rv3161c		Rv3161c			
NC_002945.3	Mycobrowser_v4	CDS	3488306	3488896	.	-	0	Mb3187c	Mb3187c		POSSIBLE INTEGRAL MEMBRANE PROTEIN	Mb3187c, -, len: 196 aa. Similar to 5' end of Rv3162c, len: 145 aa, from Mycobacterium tuberculosis strain H37Rv, (86.7% identity in 98 aa overlap). Possible integral membrane protein, with some similarity to C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical protein from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa overlap); and other hypothetical proteins from other organisms. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*),leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TX49	No									Q7TX49	A0A1R3Y3B5									
NC_002945.3	Mycobrowser_v4	CDS	3555400	3555618	.	+	0	Mb3253	Mb3253		CONSERVED HYPOTHETICAL PROTEIN	Mb3253, -, len: 72 aa. Equivalent to Rv3224B, len: 72 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis.	Q7TWY7	No	conserved hypotheticals							IPR007214	Q7TWY7	A0A1R3Y3H7				Rv3224B		Rv3224B			
NC_002945.3	Mycobrowser_v4	CDS	3488893	3490164	.	-	0	Mb3188c	Mb3188c		POSSIBLE CONSERVED SECRETED PROTEIN	Mb3188c, -, len: 423 aa. Equivalent to Rv3163c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 423 aa overlap). Possible conserved secreted protein, with some similarity to other hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from Streptomyces coelicolor (460 aa), FASTA scores: opt: 666,E(): 1.5e-33, (33.55% identity in 417 aa overlap); O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa),FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity in 389 aa overlap); etc. Also some similarity with P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium tuberculosis (317 aa), FASTA scores: opt: 198, E(): 6.3e-05, (26.75% identity in 269 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.	Q7TX48	No	cell wall and cell processes							IPR002881	Q7TX48	A0A1R3Y546				Rv3163c		Rv3163c			
NC_002945.3	Mycobrowser_v4	CDS	3511845	3512879	.	-	0	Mb3213c	Mb3213c		PROBABLE TRANSPOSASE	Mb3213c, -, len: 344 aa. Equivalent to Rv3191c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable transposase,similar to many especially Q9K2N8 PUTATIVE TRANSPOSASE from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 837, E(): 1.3e-43, (42.55% identity in 336 aa overlap); Q9RBF4 INSERTION SEQUENCE IS1088 from Alcaligenes eutrophus (Ralstonia eutropha) (342 aa), FASTA scores: opt: 823, E(): 9.2e-43, (43.05% identity in 337 aa overlap); and Q51379 PUTATIVE TRANSPOSASE from Pseudomonas alcaligenes (338 aa), FASTA scores: opt: 818, E(): 1.8e-42, (42.35% identity in 333 aa overlap). Contains probable helix-turn-helix motif from aa 25 to 46 (Score 1968, +5.89 SD).	Q7TX24	No	insertion seqs and phages							IPR001584,IPR009057,IPR012337,IPR025246	Q7TX24	A0A1R3Y3D3				Rv3191c		Rv3191c			
NC_002945.3	Mycobrowser_v4	CDS	3491164	3491646	.	-	0	Mb3190c	Mb3190c		unknown protein	Mb3190c, -, len: 160 aa. Equivalent to Rv3165c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein.	Q7TX46	No	conserved hypotheticals								Q7TX46	A0A1R3Y3I7				Rv3165c		Rv3165c			
NC_002945.3	Mycobrowser_v4	CDS	3491643	3492602	.	-	0	Mb3191c	Mb3191c		CONSERVED HYPOTHETICAL PROTEIN	Mb3191c, -, len: 319 aa. Equivalent to Rv3166c,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 319 aa overlap). Probable transmembrane protein, similar but longer (52 aa) to O32895|MLCB1779.35c hypothetical protein from Mycobacterium leprae (119 aa), FASTA scores: opt: 289,E(): 3.7e-10, (44.25% identity in 122 aa overlap). Also some similarity to Q9Z536|SC9B2.23c PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (339 aa), FASTA scores: opt: 247, E(): 2.5e-07, (28.2% identity in 326 aa overlap); and in N-terminus to Q9RS20|DR2307 PUTATIVE MULTIDRUG-EFFLUX TRANSPORTER from Deinococcus radiodurans (410 aa), FASTA scores: opt: 135,E(): 1, (32.35% identity in 136 aa overlap).	Q7TX45	No	conserved hypotheticals							IPR025403	Q7TX45	A0A1R3Y3N5				Rv3166c		Rv3166c			
NC_002945.3	Mycobrowser_v4	CDS	3492682	3493308	.	-	0	Mb3192c	Mb3192c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3192c, -, len: 208 aa. Equivalent to Rv3167c,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Probable transcriptional regulator, tetR family, similar to several transcriptional regulators e.g. Q9L2A4|SC8F4.22c (TETR/ACRR FAMILY) from Streptomyces coelicolor (234 aa),FASTA scores: opt: 317, E(): 7.5e-13, (33.35% identity in 210 aa overlap); Q9RK47|SCF12.11 (TETR/ACRR FAMILY) from Streptomyces coelicolor (206 aa), FASTA scores: opt: 293,E(): 2.1e-11, (32.65% identity in 199 aa overlap); Q54288 REGULATOR OF ANTIBIOTIC TRANSPORT COMPLEXES (TETR/ACRR FAMILY) (204 aa), FASTA scores: opt: 260, E(): 2.4e-09,(30.75% identity in 205 aa overlap); etc. Equivalent to AAK47595 from Mycobacterium tuberculosis strain CDC1551 but shorter 21 aa. Contains probable helix-turn-helix motif from aa 42 to 63 (Score 1727, +5.07 SD). MAY BE BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TX44	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TX44	A0A1R3Y3A3				Rv3167c		Rv3167c			
NC_002945.3	Mycobrowser_v4	CDS	3493353	3494489	.	+	0	Mb3193	Mb3193		putative aminoglycoside phosphotransferase	Mb3193, -, len: 378 aa. Equivalent to Rv3168, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 378 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. Q9M7Y6|F3E22.6 from Arabidopsis thaliana (Mouse-ear cress) (314 aa), FASTA scores: opt: 236, E(): 1.1e-07, (27.35% identity in 234 aa overlap); Q9RYW2|DRA0194 from Deinococcus radiodurans (386 aa), FASTA scores: opt: 207,E(): 9.1e-06, (23.45% identity in 320 aa overlap); etc. Also some similarity with O69727|Rc3761c|MTV025.109c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (351 aa), FASTA scores: opt: 193, E(): 6.4e-05, (29.4% identity in 242 aa overlap).	Q7TX43	No	virulence, detoxification, adaptation							IPR002575,IPR011009	Q7TX43	A0A1R3Y3C4				Rv3168		Rv3168			
NC_002945.3	Mycobrowser_v4	CDS	3707297	3707788	.	+	0	Mb3381	Mb3381		PROBABLE TRANSPOSASE	Mb3381, -, len: 163 aa. Equivalent to Rv3348, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Probable transposase,partially similar to several insertion elements e.g. P19834|YI11_STRCL INSERTION ELEMENT IS116 HYPOTHETICAL 44.8 KDA PROTEIN (SIMILAR TO IS900 OF MYCOBACTERIUM PARATUBERCULOSIS) from Streptomyces clavuligerus (399 aa),FASTA scores: opt: 146, E(): 0.016, (29.1% identity in 158 aa overlap).	Q7TTJ5	No	insertion seqs and phages							IPR002525	Q7TTJ5	A0A0G2QBZ4				Rv3348		Rv3348			
NC_002945.3	Mycobrowser_v4	CDS	3498694	3499296	.	-	0	Mb3198c	Mb3198c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY)	Mb3198c, -, len: 200 aa. Equivalent to Rv3173c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Probable transcriptional regulatory protein tetR family, similar to several bacterial putative regulatory proteins e.g. Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa),FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity in 195 aa overlap); O85695|3SCF60.04 from Streptomyces lividans and Streptomyces coelicolor (192 aa), FASTA scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa overlap); BAB50853|MLR4117 from Rhizobium loti (Mesorhizobium loti) (205 aa), FASTA scores: opt: 280,E(): 5.5e-11, (31.45% identity in 194 aa overlap); BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti) (194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05% identity in 185 aa overlap); etc. Also similar to other regulators from Mycobacterium tuberculosis e.g. P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: 154, E(): 0.0013, (38.8% identity in 80 aa overlap). Contains probable helix-turn-helix motif from aa 39 to 60 (Score 1251, +3.45 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TX39	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TX39	A0A1R3Y553				Rv3173c		Rv3173c			
NC_002945.3	Mycobrowser_v4	CDS	3499389	3500096	.	+	0	Mb3199	Mb3199		PROBABLE SHORT-CHAIN DEHYDROGENASE/REDUCTASE	Mb3199, -, len: 235 aa. Equivalent to Rv3174, len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 235 aa overlap). Probable oxidoreductase short-chain dehyrogenase/reductase (EC 1.-.-.-), similar to others e.g. Q9RPT7|SITS from Streptomyces albus (223 aa), FASTA scores: opt: 654, E(): 6.1e-32, (49.3% identity in 215 aa overlap); Q9RI61|SCJ11.46 from Streptomyces coelicolor (230 aa),FASTA scores: opt: 626, E(): 2.9e-30, (50.9% identity in 224 aa overlap); Q9A5Z1|CC2306 from Caulobacter crescentus (252 aa), FASTA scores: opt: 430, E(): 1.3e-18, (39.45% identity in 228 aa overlap); Q51641 INSECT-TYPE DEHYDROGENASE (249 aa), FASTA scores: opt: 301, E(): 5.7e-11, (38.3% identity in 188 aa overlap); Q9HXC9|PA3883 from Pseudomonas aeruginosa (276 aa), FASTA scores: opt: 296, E(): 1.2e-10, (29.55% identity in 247 aa overlap); etc. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TX38	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040	Q7TX38	A0A1R3Y3Z4				Rv3174		Rv3174			
NC_002945.3	Mycobrowser_v4	CDS	3514098	3514559	.	+	0	Mb3214	Mb3214		CONSERVED HYPOTHETICAL ALANINE AND PROLINE-RICH PROTEIN	Mb3214, -, len: 153 aa. Equivalent to Rv3192, len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). Conserved hypothetical ala- and pro-rich protein, with weak similarity to N-terminal half of several proteins e.g. Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa),FASTA scores: opt: 245, E(): 3.7e-08, (33.1% identity in 157 aa overlap); O30260|AF2411 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (363 aa), FASTA scores: opt: 144, E(): 0.072, (32.6% identity in 92 aa overlap); Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa),FASTA scores: opt: 133, E(): 0.33, (25.15% identity in 159 aa overlap).	Q7TX23	No	conserved hypotheticals							IPR011251	Q7TX23	A0A1R3Y3D0				Rv3192		Rv3192			
NC_002945.3	Mycobrowser_v4	CDS	3500111	3501598	.	+	0	Mb3200	Mb3200		POSSIBLE AMIDASE (AMINOHYDROLASE)	Mb3200, -, len: 495 aa. Equivalent to Rv3175, len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Possible amidase (EC 3.5.1.-), similar to others e.g. Q9F6D0|ZHUL ENANTIOMER SELECTIVE AMIDASE from Streptomyces sp. R1128 (507 aa),FASTA scores: opt: 1328 ,E(): 7.5e-69, (44.5% identity in 492 aa overlap); BAB51815|MLR5350 PROBABLE AMIDASE from Rhizobium loti (Mesorhizobium loti) (457 aa), FASTA scores: opt: 7487, E(): 1.3e-35, (35.9% identity in 482 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC 3.5.1.4) from Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 532, E(): 3.2e-23, (32.05% identity in 471 aa overlap); etc. But also similar to glutamyl-tRNA amidotransferases who belong to amidase family e.g. Q9RTA9|DR1856 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE, SUBUNIT A from Deinococcus radiodurans (482 aa), FASTA scores: opt: 560, E(): 8.2e-25, (30.6% identity in 513 aa overlap); Q9LCX3|GATA GLU/ASP-TRNA AMIDOTRANSFERASE SUBUNIT A from Thermus aquaticus (subsp. thermophilus) (471 aa), FASTA scores: opt: 558, E(): 1.1e-24, (30.85% identity in 486 aa overlap); Q49091|GATA_MORCA GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A (EC 6.3.5.-) from Moraxella catarrhalis (492 aa), FASTA scores: opt: 526, E(): 7.5e-23, (30.45% identity in 473 aa overlap); etc. SEEMS TO BELONG TO THE AMIDASE FAMILY. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TX37	No	intermediary metabolism and respiration							IPR000120,IPR023631	Q7TX37	A0A1R3Y3J8				Rv3175		Rv3175			
NC_002945.3	Mycobrowser_v4	CDS	3527147	3528214	.	-	0	Mb3225c	Mb3225c		POSSIBLE TRANSMEMBRANE CATION TRANSPORTER	Mb3225c, -, len: 355 aa. Equivalent to Rv3200c,len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 355 aa overlap). Possible transmembrane cation transporter, similar to many transmembrane proteins and putative potassium channels e.g. Q9XA52|SCGD3.27C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (365 aa), FASTA scores: opt: 1022, E(): 2.6e-53, (49.85% identity in 325 aa overlap); Q9RRZ3|DR2336 PUTATIVE POTASSIUM CHANNEL from Deinococcus radiodurans (320 aa),FASTA scores: opt: 436, E(): 1e-18, (30.9% identity in 304 aa overlap); O28600|AF1673 PUTATIVE POTASSIUM CHANNEL from Archaeoglobus fulgidus (314 aa), FASTA scores: opt: 363,E(): 2.1e-14, (27.2% identity in 309 aa overlap); Q57604|Y13B_METJAMJ0138.1|MJ0138.1 PUTATIVE POTASSIUM CHANNEL from Methanococcus jannaschii (333 aa), FASTA scores: opt: 356, E(): 5.7e-14, (26.0% identity in 281 aa overlap); P73132|SLL0993 POTASSIUM CHANNEL from Synechocystis sp. strain PCC 6803 (365 aa), FASTA scores: opt: 330, E(): 2.1e-12, (27.8% identity in 324 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TX13	No	cell wall and cell processes							IPR003148,IPR013099,IPR016040	Q7TX13	A0A1R3Y3F6				Rv3200c		Rv3200c			
NC_002945.3	Mycobrowser_v4	CDS	3514729	3517707	.	-	0	Mb3215c	Mb3215c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3215c, -, len: 992 aa. Equivalent to Rv3193c,len: 992 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 992 aa overlap). Probable conserved transmembrane protein, with hydrophobic N-terminal domain (~1-340 aa), highly similar to Q9CCM6|ML0644 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (983 aa), FASTA scores: opt: 5421, E(): 0, (86.15% identity in 989 aa overlap); and O53609|Rv0064|MTV030.07 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis strain H37Rv (979 aa), FASTA scores: opt: 3204, E(): 2.1e-142,(50.25% identity in 985 aa overlap). C-terminal part (709-990 aa) highly similar to O32904|MLCB1779.46 HYPOTHETICAL 29.1 KDA PROTEIN from Mycobacterium leprae (277 aa), FASTA scores: opt: 1521, E(): 3.4e-64, (82.6% identity in 282 aa overlap). Also some similarity to hypothetical proteins generally transmembrane e.g. Q9FCI4|2SC3B6.28 from Streptomyces coelicolor (815 aa),FASTA scores: opt: 951, E(): 3.4e-37, (39.2% identity in 826 aa overlap); P72637|SLL1060 from Synechocystis sp. strain PCC 6803 (1032 aa), FASTA scores: opt: 938, E(): 1.6e-36, (29.95% identity in 855 aa overlap); O28851|AF1421 from Archaeoglobus fulgidus (880 aa), FASTA scores: opt: 526, E(): 2.6e-17, (28.05% identity in 970 aa overlap); etc.	X2BMH8,Q7TX22	No	cell wall and cell processes								X2BMH8,Q7TX22	Q7TX22				Rv3193c		Rv3193c			
NC_002945.3	Mycobrowser_v4	CDS	3831660	3832613	.	+	0	Mb3496	Mb3496		CONSERVED HYPOTHETICAL PROTEIN	Mb3496, -, len: 317 aa. Equivalent to Rv3467, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(98.1% identity in 317 aa overlap). Conserved hypothetical ORF in REP13E12 repeat, identical to ORF's from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c, MTCY09F9.19,cMTCY336.17. Also identical to Mycobacterium bovis Q50655 HYPOTHETICAL 34.6 KD PROTEIN (317 aa) in identical repeat.	Q7TWG4	No	insertion seqs and phages							IPR003615,IPR003870	Q7TWG4	A0A1R3Y4A6				Rv3467		Rv3467			
NC_002945.3	Mycobrowser_v4	CDS	3502697	3503557	.	+	0	Mb3203	Mb3203		POSSIBLE PEROXIDASE (NON-HAEM PEROXIDASE)	Mb3203, -, len: 286 aa. Equivalent to Rv3177, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible peroxidase (non-haem peroxidase) (EC 1.11.1.-), highly similar to Q9KJF9|W78 CULTIVAR SPECIFICITY PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) W78 from Rhizobium leguminosarum (287 aa), FASTA scores: opt: 1059, E(): 2.3e-59, (61.4% identity in 272 aa overlap); BAB48728|MLL1328 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 746,E(): 1.1e-39, (43.25% identity in 282 aa overlap). Similar to nonheme chloroperoxidases and related esterases e.g. O73957|SAL LIPOLYTIC ENZYME from Sulfolobus acidocaldarius (314 aa), FASTA scores: opt: 408, E(): 1.9e-18, (32.4% identity in 287 aa overlap); Q9AJM9|BIOH PROTEIN INVOLVED IN BIOTIN SYNTHESIS from Kurthia sp. 538-KA26 (267 aa),FASTA scores: opt: 324 ,E(): 3.2e-13, (30.0% identity in 250 aa overlap); Q9CBB1|ML2269 PUTATIVE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (265 aa); O05691|THCF_RHOER NON-HEME HALOPEROXIDASE (EC 1.11.1.-) from Rhodococcus erythropolis (SIMILAR TO OTHER BACTERIAL NON-HEME BROMO-AND CHLORO-PEROXIDASES) (274 aa),FASTA scores: opt: 279, E(): 2.2e-10, (29.0% identity in 276 aa overlap); Q53540|EST ESTERASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas putida (276 aa), FASTA scores: opt: 271, E(): 7.1e-10, (29.65% identity in 280 aa overlap); etc. Also similar to O06420|BPOC|Rv0554|MTCY25D10.33 HYPOTHETICAL 28.3 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from M. tuberculosis (262 aa), FASTA scores: opt: 280 ,E(): 1.8e-10, (28.0% identity in 257 aa overlap). Equivalent to AAK47605 from Mycobacterium tuberculosis strain CDC1551 (300 aa) but shorter 14 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD.	Q7TX34	No	virulence, detoxification, adaptation							IPR000073	Q7TX34	A0A1R3Y3D2				Rv3177		Rv3177			
NC_002945.3	Mycobrowser_v4	CDS	3503688	3504047	.	+	0	Mb3204	Mb3204		CONSERVED HYPOTHETICAL PROTEIN	Mb3204, -, len: 119 aa. Equivalent to Rv3178, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical protein,with some similarity to other hypothetical bacterial proteins (principaly mycobacterium and streptomyces proteins) e.g. P71854|Rv3547|MTCY03C7.09c from M. tuberculosis strain H37Rv (151 aa), FASTA scores: opt: 310, E(): 2e-14, (40.5% identity in 116 aa overlap); Q9ZH81 from M. paratuberculosis (144 aa), FASTA scores: opt: 274, E(): 5.6e-12, (38.9% identity in 108 aa overlap); O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa), FASTA scores: opt: 235,E(): 2.7e-09, (35.2% identity in 108 aa overlap); Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148 aa); Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa); etc. Equivalent to AAK47606 from Mycobacterium tuberculosis strain CDC1551 (171 aa) but shorter 52 aa.	Q7TX33	No	conserved hypotheticals							IPR004378	Q7TX33	A0A1R3Y3C2				Rv3178		Rv3178			
NC_002945.3	Mycobrowser_v4	CDS	3504868	3506157	.	+	0	Mb3205	Mb3205		conserved protein	Mb3205, -, len: 429 aa. Equivalent to Rv3179, len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Conserved hypothetical protein, highly similar to Q9KH61 PUTATIVE ATP/GTP BINDING PROTEIN from Mycobacterium smegmatis (428 aa), FASTA scores: opt: 2466, E(): 1.5e-148, (89.7% identity in 428 aa overlap) (no article found on the NCBI web site (July 2001)); and to other hypothetical bacterial proteins e.g. O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411 aa), FASTA scores: opt: 1031, E(): 8e-58, (41.5% identity in 417 aa overlap); BAB54715|MLR9349 from Rhizobium loti (Mesorhizobium loti) (435 aa), FASTA scores: opt: 365, E(): 1.1e-15, (31.75% identity in 416 aa overlap); etc. Equivalent to AAK47609 from Mycobacterium tuberculosis strain CDC1551 (454 aa) but shorter 25 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TX32	No	conserved hypotheticals							IPR025420,IPR027417	Q7TX32	A0A1R3Y3B8				Rv3179		Rv3179			
NC_002945.3	Mycobrowser_v4	CDS	3507965	3508294	.	+	0	Mb3209	Mb3209		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb3209, -, len: 109 aa. Equivalent to Rv3183, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Possible transcriptional regulator, similar to others e.g. Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa), FASTA scores: opt: 119, E(): 0.47, (40.55% identity in 74 aa overlap); Q9X153|TM1330 from Thermotoga maritima (111 aa),FASTA scores: opt: 115, E(): 0.91, (40.35% identity in 57 aa overlap); P95258|Rv1956|MTCY09F9.08c (alias AAK46277 putative DNA-binding protein from strain CDC1551) (149 aa), FASTA scores: opt: 116, E(): 1, (42.25% identity in 71 aa overlap). Also similar to O53467|Rv2021c|MTV018.08c from Mycobacterium tuberculosis (101 aa), FASTA scores: opt: 214, E(): 5.8e-07, (43.0% identity in 107 aa overlap). Contains probable helix-turn-helix motif from aa 51 to 72 (Score 1803, +5.33 SD).	Q7TX28	No	regulatory proteins							IPR001387,IPR010982	Q7TX28	A0A1R3Y409				Rv3183		Rv3183			
NC_002945.3	Mycobrowser_v4	CDS	3508832	3509179	.	+	0	Mb3210	Mb3210		CONSERVED HYPOTHETICAL PROTEIN	Mb3210, -, len: 115 aa. Equivalent to Rv3188, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Conserved hypothetical protein, with similarity to other proteins from Mycobacterium tuberculosis: Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 HYPOTHETICAL PROTEIN (113 aa), FASTA scores: opt: 184, E(): 8.1e-06,(28.45% identity in 109 aa overlap); and O06299|Rv0348|MTCY13E10.08 HYPOTHETICAL PROTEIN (217 aa),FASTA scores: opt: 129, E(): 0.074, (30.0% identity in 100 aa overlap). Also some similarity with C-terminus of Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 114, E(): 0.76, (30.0% identity in 110 aa overlap) (for this one, no similarity exists in the N-terminal region with the N-terminus of other regulatory components of sensory transduction systems).	Q7TX27	No	conserved hypotheticals							IPR024467	Q7TX27	A0A1R3Y3K0				Rv3188		Rv3188			
NC_002945.3	Mycobrowser_v4	CDS	3509176	3509796	.	+	0	Mb3211	Mb3211		CONSERVED HYPOTHETICAL PROTEIN	Mb3211, -, len: 206 aa. Equivalent to Rv3189, len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Conserved hypothetical protein, weakly similar to other proteins from Mycobacterium tuberculosis e.g. O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa), FASTA scores: opt: 135, E(): 0.79, (27.8% identity in 187 aa overlap); and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186 aa),FASTA scores: opt: 122, E(): 0.85, (32.25% identity in 93 aa overlap).	Q7TX26	No	conserved hypotheticals							IPR014914	Q7TX26	A0A1R3Y3Q0				Rv3189		Rv3189			
NC_002945.3	Mycobrowser_v4	CDS	3538342	3539199	.	-	0	Mb3232c	Mb3232c		conserved protein	Mb3232c, -, len: 285 aa. Equivalent to Rv3207c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Hypothetical protein,highly similar but shorter (57 aa) to Q9CCG9|ML0816 HYPOTHETICAL PROTEIN from Mycobacterium leprae (341 aa),FASTA scores: opt: 1676, E(): 9.7e-96, (81.0% identity in 284 aa overlap). Also similar to C-terminus of Q9FBI6|SCP8.36 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (559 aa), FASTA scores: opt: 426, E(): 8.4e-19,(37.35% identity in 281 aa overlap); and similar to other hypothetical proteins (generally membrane proteins) e.g. Q9K456|SC2H12.28C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (314 aa), FASTA scores: opt: 341,E(): 8.8e-14, (29.75% identity in 296 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142).	Q7TX06	No	conserved hypotheticals							IPR006026,IPR022603,IPR024079	Q7TX06	A0A1R3Y3F7				Rv3207c		Rv3207c			
NC_002945.3	Mycobrowser_v4	CDS	3517799	3518821	.	-	0	Mb3216c	Mb3216c		POSSIBLE CONSERVED SECRETED PROTEIN	Mb3216c, -, len: 340 aa. Equivalent to Rv3194c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Possible conserved secreted protein (N-terminal stretch hydrophobic),equivalent to Q9CCM7|ML0643 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (340 aa), FASTA scores: opt: 1822,E(): 1.6e-102, (80.3% identity in 340 aa overlap). Also similar to other proteins e.g. Q9FCI6|2SC3B6.26 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (364 aa),FASTA scores: opt: 430, E(): 1.1e-18, (40.95% identity in 359 aa overlap); Q9S3Y5|SDRC SDRC PROTEIN from Streptomyces coelicolor (241 aa), FASTA scores: opt: 396,E(): 8.9e-17, (35.2% identity in 318 aa overlap) (similarity in part for this one); O34470|YLBL YLBL PROTEIN from Bacillus subtilis (350 aa), FASTA scores: opt: 385, E(): 5.6e-16, (27.7% identity in 350 aa overlap); etc.	Q7TX21	No	cell wall and cell processes							IPR001478,IPR008269,IPR014721,IPR020568,IPR027065	Q7TX21	A0A1R3Y3D6				Rv3194c		Rv3194c			
NC_002945.3	Mycobrowser_v4	CDS	3518899	3520317	.	+	0	Mb3217	Mb3217		CONSERVED HYPOTHETICAL PROTEIN	Mb3217, -, len: 472 aa. Equivalent to Rv3195, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 472 aa overlap). Hypothetical protein,equivalent to Q49746|ML0642|B1937_C3_231 HYPOTHETICAL 50.3 KDA PROTEIN from Mycobacterium leprae (479 aa), FASTA scores: opt: 2503, E(): 1e-138, (79.35% identity in 475 aa overlap). Similar in part to Q9FCI9|2SC3B6.23c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (487 aa), FASTA scores: opt: 1382, E(): 2.7e-73, (46.4% identity in 489 aa overlap); Q9X8I7|SCE9.14 HYPOTHETICAL 41.2 KDA PROTEIN from Streptomyces coelicolor (375 aa),FASTA scores: opt: 319, E(): 2.4e-11, (25.6% identity in 383 aa overlap); etc.	Q7TX20	No	conserved hypotheticals							IPR018766	Q7TX20	A0A1R3Y569				Rv3195		Rv3195			
NC_002945.3	Mycobrowser_v4	CDS	3520323	3521222	.	+	0	Mb3218	Mb3218		CONSERVED HYPOTHETICAL PROTEIN	Mb3218, -, len: 299 aa. Equivalent to Rv3196, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Hypothetical protein,with some similarity to other hypothetical proteins e.g. Q9FCJ5|2SC3B6.17c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (442 aa), FASTA scores: opt: 233,E(): 3.5e-07, (29.9% identity in 261 aa overlap).	Q7TX19	No	conserved hypotheticals								Q7TX19	A0A1R3Y416				Rv3196		Rv3196			
NC_002945.3	Mycobrowser_v4	CDS	3521569	3522912	.	+	0	Mb3220	Mb3220		PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER	Mb3220, -, len: 447 aa. Equivalent to Rv3197, len: 447 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 447 aa overlap). Probable conserved ATP-binding protein ABC transporter, highly similar to Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140,(83.0% identity in 447 aa overlap). Interestingly, the N-terminal half (1-219 aa) corresponds to Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68,(88.6% identity in 219 aa overlap); and the C-terminal half (239-447 aa) corresponds to Q49745|B1937_C2_179 HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt: 1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap); two adjacent orfs from Mycobacterium leprae. Also highly similar to other proteins (generally ABC transporters) e.g. Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340,E(): 1.8e-71, (45.9% identity in 449 aa overlap); O65576|ABC1AT ABC1 PROTEIN (alias Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa overlap); O27682|MTH1645 ABC TRANSPORTER from Methanobacterium thermoautotrophicum (623 aa), FASTA scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TX17	No	cell wall and cell processes							IPR002575,IPR004147,IPR011009	Q7TX17	A0A1R3Y3R3				Rv3197		Rv3197			
NC_002945.3	Mycobrowser_v4	CDS	3525880	3526134	.	+	0	Mb3223	Mb3223		POSSIBLE GLUTAREDOXIN PROTEIN	Mb3223, -, len: 84 aa. Equivalent to Rv3198A, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Possible glutaredoxin protein (EC 1.-.-.-), highly similar to Q9FCK1|2SC3B6.11c PUTATIVE GLUTAREDOXIN-LIKE PROTEIN from Streptomyces coelicolor (80 aa), FASTA scores: opt: 293, E(): 2.2e-14,(55.15% identity in 78 aa overlap); and Q9RSN9|DR2085 PUTATIVE GLUTAREDOXIN from Deinococcus radiodurans (81 aa), FASTA scores: opt: 198, E(): 1.2e-07, (53.55% identity in 56 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9X8C2|SCE36.09 HYPOTHETICAL 13.0 KDA PROTEIN from Streptomyces coelicolor (114 aa), FASTA scores: opt: 181, E(): 2.6e-06, (44.45% identity in 72 aa overlap).	Q7TX15	No	intermediary metabolism and respiration							IPR002109,IPR011915,IPR012336	Q7TX15	A0A1R3Y3D8				Rv3198A		Rv3198A			
NC_002945.3	Mycobrowser_v4	CDS	3528276	3531581	.	-	0	Mb3226c	Mb3226c		PROBABLE ATP-DEPENDENT DNA HELICASE	Mb3226c, -, len: 1101 aa. Equivalent to Rv3201c,len: 1101 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1101 aa overlap). Probable ATP-dependent DNA helicase (EC 3.6.1.-), similar to others e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 aa), FASTA scores: opt: 1209, E(): 5.4e-63, (38.45% identity in 1199 aa overlap); P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 403, E(): 6.5e-16, (28.15% identity in 717 aa overlap); Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa),FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity in 1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp. (512 aa; fragment), FASTA scores: opt: 290, E(): 2e-09,(27.95% identity in 479 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TX12	No	information pathways							IPR000212,IPR011335,IPR014016,IPR014017,IPR027417	Q7TX12	A0A1R3Y3E6				Rv3201c		Rv3201c			
NC_002945.3	Mycobrowser_v4	CDS	3531578	3534745	.	-	0	Mb3227c	Mb3227c		POSSIBLE ATP-DEPENDENT DNA HELICASE	Mb3227c, -, len: 1055 aa. Equivalent to Rv3202c,len: 1055 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1055 aa overlap). Possible ATP-dependent DNA helicase (EC 3.6.1.-), showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 PUTATIVE ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 MISMATCH REPAIR PROTEIN MUTU (DNA HELICASE II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06,(23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar to Q9FDU2|ORF3 ORF3 PROTEIN (FRAGMENT) from Streptomyces griseus (551 aa), FASTA scores: opt: 800,E(): 1.7e-37, (36.2% identity in 525 aa overlap); and Q9ZG15 HYPOTHETICAL 35.5 KDA PROTEIN from Rhodococcus erythropolis (323 aa), FASTA scores: opt: 232, E(): 9.7e-06, (28.55% identity in 266 aa overlap).	Q7TX11	No	information pathways							IPR000212,IPR014016,IPR014017,IPR027417	Q7TX11	A0A1R3Y579				Rv3202c		Rv3202c			
NC_002945.3	Mycobrowser_v4	CDS	3535859	3536164	.	+	0	Mb3229	Mb3229		POSSIBLE DNA-METHYLTRANSFERASE (MODIFICATION METHYLASE)	Mb3229, -, len: 101 aa. Equivalent to Rv3204, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 101 aa overlap). Possible DNA methyltransferase (EC 2.1.1.-), similar to many hypothetical bacteriel proteins and methyltransferases e.g. Q9KT40|VC1065 METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE-RELATED PROTEIN from Vibrio cholerae (100 aa), FASTA scores: opt: 170, E(): 2.8e-05, (34.35% identity in 99 aa overlap); Q9UTN9|SPAC1250.04c PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (108 aa), FASTA scores: opt: 161, E(): 0.00013,(36.65% identity in 101 aa overlap); Q9YDF4|APE0959 175 AA LONG HYPOTHETICAL METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE from Aeropyrum pernix (175 aa), FASTA scores: opt: 144, E(): 0.003, (37.95% identity in 87 aa overlap); Q50855 PUTATIVE METHYLGUANINE-DNA METHYLTRANSFERASE from Myxococcus xanthus (147 aa), FASTA scores: opt: 141, E(): 0.0041, (37.65% identity in 93 aa overlap); etc.	Q7TX09	No	information pathways							IPR011991,IPR014048	Q7TX09	A0A1R3Y3S1				Rv3204		Rv3204			
NC_002945.3	Mycobrowser_v4	CDS	3539545	3540231	.	+	0	Mb3233	Mb3233		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3233, -, len: 228 aa. Equivalent to Rv3208, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Probable transcriptional regulator tetR family, equivalent to Q9CCH0|ML0815 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (228 aa), FASTA scores: opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa overlap). Also highly similar to Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa), FASTA scores: opt: 629, E(): 4e-34,(45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R (FRAGMENT) from Streptomyces coelicolor A3(2) (149 aa),FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity in 147 aa overlap); Q9K3T5|SCE66.08 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (225 aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15% identity in 212 aa overlap); Q9RYK4|DRA0308 TRANSCRIPTIONAL REGULATOR, TETR FAMILY from Deinococcus radiodurans (239 aa), FASTA scores: opt: 290, E(): 6.5e-12, (30.5% identity in 223 aa overlap); etc. And also similar to Mycobacterium tuberculosis proteins P96381|Rv1019|MTCY10G2.30c HYPOTHETICAL 21.7 KDA PROTEIN (197 aa), FASTA scores: opt: 356, E(): 2.7e-16, (34.4% identity in 189 aa overlap); MTV034_4; MTY07A7A_3; MTV032_1; MTCY07A7_12; etc. Contains probable helix-turn-helix motif at aa 60-81 (Score 1517, +4.35 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TX05	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TX05	A0A1R3Y3F4				Rv3208		Rv3208			
NC_002945.3	Mycobrowser_v4	CDS	3540815	3541375	.	+	0	Mb3235	Mb3235		conserved hypothetical threonine and proline rich protein	Mb3235, -, len: 186 aa. Equivalent to Rv3209, len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Conserved hypothetical thr-, pro-rich protein, equivalent (but shorter 36 aa in N-terminus) to Q9CCH2|ML0813 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (195 aa), FASTA scores: opt: 508, E(): 1.4e-15, (58.4% identity in 185 aa overlap). Also some similarity with Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from M. tuberculosis (299 aa), FASTA scores: opt: 339, E(): 3.7e-08, (35.0% identity in 180 aa overlap); and Q9CCE9|MMPS3|ML0877 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (293 aa), FASTA scores: opt: 272,E(): 2.8e-05, (36.4% identity in 173 aa overlap).	Q7TX03	No	conserved hypotheticals							IPR008693	Q7TX03	A0A1R3Y3G4				Rv3209		Rv3209			
NC_002945.3	Mycobrowser_v4	CDS	3543935	3545158	.	+	0	Mb3238	Mb3238		conserved alanine valine rich protein	Mb3238, -, len: 407 aa. Equivalent to Rv3212, len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 407 aa overlap). Hypothetical ala-,val-rich protein, equivalent to Q9CCH4|ML0810 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (407 aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85% identity in 407 aa overlap). Weak similarity to several eukaryotic transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 TRANS-ACTING TRANSCRIPTIONAL PROTEIN from Herpes simplex virus (type 1 / strain 17) (775 aa), FASTA scores: opt: 115, E(): 2, (26.9% identity in 334 aa overlap).	Q7TX00	No	conserved hypotheticals							IPR011047	Q7TX00	A0A1R3Y3M0				Rv3212		Rv3212			
NC_002945.3	Mycobrowser_v4	CDS	3545235	3546035	.	-	0	Mb3239c	Mb3239c		POSSIBLE SOJ/PARA-RELATED PROTEIN	Mb3239c, -, len: 266 aa. Equivalent to Rv3213c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(99.624% identity in 266 aa overlap). Possible soj/parA-related protein, very similar in particular to Soj/ParA proteins (and relatives) from Bacillus subtilis that inhibit the initiation of sporulation by preventing phosphorylation of Spo0A (see first citation below for more information) e.g. Q9S228|SCI51.12c from Streptomyces coelicolor (340 aa), FASTA scores: opt: 746, E(): 1.6e-40,(48.2% identity in 249 aa overlap); Q9HT11|SOJ|PA5563 from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 649,E(): 2.1e-34, (42.2% identity in 256 aa overlap); Q9PB62|XF2282 from Xylella fastidiosa (264 aa), FASTA scores: opt: 624, E(): 8.3e-33, (42.25% identity in 251 aa overlap); Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus halodurans (253 aa), FASTA scores: opt: 621, E(): 1.2e-32,(41.55% identity in 248 aa overlap); P37522|SOJ_BACSU (253 aa), FASTA scores: opt: 620, E(): 1.4e-32, (41.65% identity in 245; etc. Also similar to various mycobacterial proteins: U00021_10 from Mycobacterium leprae, MTCI125_29 from Mycobacterium tuberculosis,MLCB1351_6 from Mycobacterium leprae,MTV028_9c|Rv3918c|PARA PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium tuberculosis, MSGDNAB_18 from Mycobacterium leprae. SEEMS TO BELONG TO THE PARA FAMILY.	Q7TWZ9	No	cell wall and cell processes							IPR002586,IPR027417	Q7TWZ9	A0A1R3Y3T6				Rv3213c		Rv3213c			
NC_002945.3	Mycobrowser_v4	CDS	3655230	3655541	.	-	0	Mb3341c	Mb3341c		SECRETED PROTEIN ANTIGEN	Mb3341c, -, len: 103 aa. Equivalent to Rv3312A,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Secreted protein antigen, described in Corixa patent as having N-terminal sequence YYWCPGQPFDPAWGP. Equivalent to AAK47756 from Mycobacterium tuberculosis strain CDC1551 (114 aa) but shorter 11 aa.	X2BN94,Q7TWR6	No	cell wall and cell processes								X2BN94,Q7TWR6	Q7TWR6				Rv3312A		Rv3312A			
NC_002945.3	Mycobrowser_v4	CDS	3548063	3548395	.	+	0	Mb3242	Mb3242		gcn5-related n-acetyltransferase, pseudogene	Mb3242, -, len: 110 aa. Equivalent to Rv3216, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Possible acetyltransferase (2.3.1.-), similar but shorter to many e.g. Q9AB32|CC0402 ACETYLTRANSFERASE (GNAT FAMILY) from Caulobacter crescentus (159 aa), FASTA scores: opt: 325,E(): 3.8e-17, (45.65% identity in 103 aa overlap); P79081|ATS1 PUTATIVE ACETYLTRANSFERASE ATS1 from Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa overlap); Q9I640|PA0478 PROBABLE N-ACETYLTRANSFERASE from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 308,E(): 6.9e-16, (50.0% identity in 98 aa overlap); Q9KHE3 PUTATIVE ACETYLTRANSFERASE from Anabaena sp. strain PCC 7120 (164 aa), FASTA scores: opt: 269, E(): 5.4e-13,(41.75% identity in 103 aa overlap); etc. Also some similarity to diamine acetyltransferases (EC 2.3.1.57) e.g. Q28999|ATDA_PIG|SAT from Sus scrofa (Pig) (171 aa),FASTA scores: opt: 152, E(): 0.00025, (23.15% identity in 108 aa overlap).		No	intermediary metabolism and respiration													Rv3216		Rv3216			
NC_002945.3	Mycobrowser_v4	CDS	3548347	3548778	.	-	0	Mb3243c	Mb3243c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3243c, -, len: 143 aa. Equivalent to Rv3217c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Probable conserved integral membrane protein, equivalent (highly similar but shorter 30 aa) to Q9CCH6|ML0806 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (173 aa). Also similar to others e.g. Q9F3L9|2SC7G11.04 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (152 aa), FASTA scores: opt: 177, E(): 0.00024, (33.8% identity in 136 aa overlap). And shows similarity to O34238|MVIN|VC0680 VIRULENCE FACTOR MVIN HOMOLOG from Vibrio (525 aa), FASTA scores: opt: 126,E(): 0.97, (30.9% identity in 68 aa overlap). First GTG taken.	Q7TWZ5	No	cell wall and cell processes								Q7TWZ5	A0A1R3Y3G1				Rv3217c		Rv3217c			
NC_002945.3	Mycobrowser_v4	CDS	3549067	3550032	.	+	0	Mb3244	Mb3244		conserved protein	Mb3244, -, len: 321 aa. Equivalent to Rv3218, len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 321 aa overlap). Conserved hypothetical protein, similar to several hypothetical bacterial proteins e.g. Q9F3M0|2SC7G11.03c from Streptomyces coelicolor (322 aa), FASTA scores: opt: 694,E(): 4.2e-35, (39.95% identity in 328 aa overlap); Q9A0J4|SPY0752 from Streptomyces pyogenes (340 aa), FASTA scores: opt: 187, E(): 0.00033, (30.5% identity in 141 aa overlap); O31502|YERQ from Bacillus subtilis (303 aa),FASTA scores: opt: 184, E(): 0.00045, (34.15% identity in 126 aa overlap); etc.	Q7TWZ4	No	conserved hypotheticals							IPR001206,IPR016064,IPR017438	Q7TWZ4	A0A1R3Y3H1				Rv3218		Rv3218			
NC_002945.3	Mycobrowser_v4	CDS	3707825	3708565	.	-	0	IS1561'	IS1561'		PROBABLE TRANSPOSASE	Mb3382c, -, len: 246 aa. Equivalent to Rv3349c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 PUTATIVE TRANSPOSASE from NOCARDIA ASTEROIDES (377 aa), FASTA scores: opt: 288, E(): 8.3e-11, (48.5% identity in 97 aa overlap); and others.	Q7TVB5	No	insertion seqs and phages							IPR002560	Q7TVB5					Rv3349c		Rv3349c			
NC_002945.3	Mycobrowser_v4	CDS	3550628	3552133	.	-	0	Mb3246c	Mb3246c		PROBABLE TWO COMPONENT SENSOR KINASE	Mb3246c, -, len: 501 aa. Equivalent to Rv3220c,len: 501 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 501 aa overlap). Probable sensor (probably histidine kinase), equivalent to Q9CCH8|ML0803 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (500 aa). Similar to others e.g. Q9F3M1|2SC7G11.01 PUTATIVE HISTIDINE KINASE (FRAGMENT) from Streptomyces coelicolor (372 aa), FASTA scores: opt: 1038, E(): 7.4e-56, (48.95% identity in 380 aa overlap); Q9A3K5|CC3198 SENSOR HISTIDINE KINASE from Caulobacter crescentus (327 aa), FASTA scores: opt: 311, E(): 1.2e-11,(33.35% identity in 201 aa overlap) (similarity only in C-terminal part for this one); Q9A2T2|CC3474 PUTATIVE SENSOR HISTIDINE KINASE from Caulobacter crescentus (547 aa); etc. C-terminal half shows similarity to many sensor proteins, that respond to various stimuli from Methanobacterium thermoautotrophicum e.g. O26568|MTH468 SENSORY TRANSDUCTION HISTIDINE KINASE (554 aa), FASTA scores: opt: 425, E(): 2.1e-18, (34.0% identity in 244 aa overlap); O26546|MTH446 SENSORY TRANSDUCTION REGULATORY PROTEIN (583 aa), FASTA scores: opt: 380, E(): 1.2e-15,(37.15% identity in 202 aa overlap); O26913|MTH823 SENSORY TRANSDUCTION REGULATORY PROTEIN (677 aa), FASTA scores: opt: 375, E(): 2.7e-15, (35.4% identity in 195 aa overlap); etc. SEEMS SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES.	Q7TWZ2	No	regulatory proteins							IPR000014,IPR003594,IPR005467,IPR011495,IPR022066	Q7TWZ2	A0A1R3Y591				Rv3220c		Rv3220c			
NC_002945.3	Mycobrowser_v4	CDS	4251842	4252870	.	-	0	Mb3873c	Mb3873c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3873c, -, len: 342 aa. Equivalent to Rv3843c,len: 342 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 342 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CDC6|ML0073 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (344 aa), FASTA scores: opt: 1420, E(): 2.6e-68, (63.05% identity in 349 aa overlap).	Q7TVJ1	No	cell wall and cell processes							IPR025565	Q7TVJ1	A0A1R3Y5E4				Rv3843c		Rv3843c			
NC_002945.3	Mycobrowser_v4	CDS	3552952	3553503	.	-	0	Mb3249c	Mb3249c		CONSERVED HYPOTHETICAL PROTEIN	Mb3249c, -, len: 183 aa. Equivalent to Rv3222c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Hypothetical protein,with some similarity to Q9SZD2|F19B15.50|AT4G29020 GLYCINE-RICH PROTEIN LIKE from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% identity in 170 aa overlap); AAK45760|MT1497.1 PE_PGRS FAMILY PROTEIN from strain CDC1551 (1408 aa), FASTA scores: opt: 137,E(): 2, (31.75% identity in 148 aa overlap); etc.	Q7TWZ0	No	conserved hypotheticals								Q7TWZ0	A0A1R3Y3U1				Rv3222c		Rv3222c			
NC_002945.3	Mycobrowser_v4	CDS	3554450	3555298	.	+	0	Mb3251	Mb3251		possible iron-regulated short-chain dehydrogenase/reductase	Mb3251, -, len: 282 aa. Equivalent to Rv3224, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 282 aa overlap). Probable oxidoreductase, possible short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to BAB49551|MLL2413 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053,E(): 6.4e-59, (57.95% identity in 276 aa overlap); Q9AB34|CC0400 SHORT CHAIN DEHYDROGENASE FAMILY PROTEIN from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59, (55.9% identity in 281 aa overlap); and Q9VB10|CG5590 HYPOTHETICAL PROTEIN (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Drosophila melanogaster (Fruit fly) (412 aa), FASTA scores: opt: 966, E(): 2.5e-53, (52.15% identity in 278 aa overlap). Similar to various proteins (principaly oxidoreductases) e.g. Q18639|C45B11.3 HYPOTHETICAL PROTEIN (SIMILAR TO THE SDR FAMILY) from Caenorhabditis elegans (293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3% identity in 271 aa overlap); Q9HZV5|PA2892 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (274 aa), FASTA scores: opt: 847, E(): 5.1e-46, (49.25% identity in 274 aa overlap); Q9I6V0|PA0182 PROBABLE SHORT-CHAIN DEHYDROGENASE (SIMILAR TO THE SDR FAMILY) from Pseudomonas aeruginosa (250 aa), FASTA scores: opt: 333,E(): 8.3e-14, (29.8% identity in 245 aa overlap); Q9HY98|PA3511 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (253 aa), FASTA scores: opt: 330,E(): 1.3e-13, (31.2% identity in 250 aa overlap); etc. Related proteins in Mycobacterium tuberculosis include MTCY02B10.14, MTCY369.14, and MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017) near C-terminus. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TWY9	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040	Q7TWY9	A0A1R3Y3J2				Rv3224		Rv3224			
NC_002945.3	Mycobrowser_v4	CDS	3555234	3555422	.	+	0	Mb3252	Mb3252		CONSERVED HYPOTHETICAL PROTEIN	Mb3252, -, len: 62 aa. Equivalent to Rv3224A, len: 62 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 62 aa overlap). Conserved hypothetical protein (possibly gene fragment), overlaps Rv3224. Similar to N-terminus of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa),FASTA scores: opt: 104, E(): 0.78, (59.37% identity in 32 aa overlap). Note that upstream ORF Rv3224B is similar to C-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis.	Q7TWY8	No	conserved hypotheticals								Q7TWY8	A0A1R3Y3H9				Rv3224A		Rv3224A			
NC_002945.3	Mycobrowser_v4	CDS	3555615	3557039	.	-	0	Mb3254c	Mb3254c		gcn5-related n-acetyltransferase, phosphorylase	Mb3254c, -, len: 474 aa. Equivalent to Rv3225c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 474 aa overlap). Possible transferase (EC 2.-.-.-). C-terminal part shows some similarity to various bacterial proteins e.g. BAB49093|MLL1809 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (298 aa), FASTA scores: opt: 557, E(): 2.8e-26,(34.55% identity in 295 aa overlap); P14509|KKA8_ECOLI|APHA AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Escherichia coli (271 aa),FASTA scores: opt: 194, E(): 0.00018, (27.75% identity in 227 aa overlap); Q53826|CPH CAPREOMYCIN PHOSPHOTRANSFERASE from Streptomyces capreolus (281 aa), FASTA scores: opt: 178, E(): 0.0017, (30.5% identity in 269 aa overlap); Q9CDM4|YWIA UNKNOWN PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (213 aa), FASTA scores: opt: 167, E(): 0.0061, (2705% identity in 149 aa overlap); Q9X843|SC9B1.24 PUTATIVE TRANSFERASE (FRAGMENT) from Streptomyces coelicolor (317 aa), FASTA scores: opt: 165, E(): 0.011, (26.05% identity in 280 aa overlap); etc. Start uncertain.	Q7TWY6	No	intermediary metabolism and respiration							IPR000182,IPR002575,IPR011009,IPR016181,IPR024165	Q7TWY6	A0A1R3Y3H8				Rv3225c		Rv3225c			
NC_002945.3	Mycobrowser_v4	CDS	3594025	3594444	.	+	0	Mb3287	Mb3287		CONSERVED HYPOTHETICAL PROTEIN	Mb3287, -, len: 139 aa. Equivalent to Rv3259, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, equivalent, but shorter 29 aa, to Q9CCJ9|ML0761 HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FASTA scores: opt: 846, E(): 2.2e-47,(89.2% identity in 139 aa overlap). C-terminus highly similar to Q9S425 HYPOTHETICAL 6.0 KDA PROTEIN (FRAGMENT) from Mycobacterium smegmatis (54 aa), FASTA scores: opt: 275, E(): 2.7e-11, (81.15% identity in 53 aa overlap). Also similar to Q9KZL3|SCE34.12 from Streptomyces coelicolor (117 aa), FASTA scores: opt: 152, E(): 0.004,(34.15% identity in 126 aa overlap). Equivalent to AAK47699 from Mycobacterium tuberculosis strain CDC1551 (175 aa) but shorter 36 aa.	Q7TWV6	No	conserved hypotheticals							IPR010428	Q7TWV6	A0A1R3Y4B0				Rv3259		Rv3259			
NC_002945.3	Mycobrowser_v4	CDS	3557163	3557921	.	-	0	Mb3255c	Mb3255c		CONSERVED HYPOTHETICAL PROTEIN	Mb3255c, -, len: 252 aa. Equivalent to Rv3226c,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Conserved hypothetical protein, similar to various hypothetical bacterial proteins e.g. Q9CCI2|ML0793 PUTATIVE BACTERIOPHAGE PROTEIN from Mycobacterium leprae (252 aa),FASTA scores: opt: 1183, E(): 3.8e-68, (70.65% identity in 252 aa overlap); BAB54183|MLR7795 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (369 aa), FASTA scores: opt: 417, E(): 2.9e-19, (33.75% identity in 252 aa overlap); O64131 YOQW PROTEIN from Bacteriophage SPBc2 (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O31916 YOQW PROTEIN from Bacillus subtilis (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O34906 YOAM PROTEIN from Bacillus subtilis (227 aa), FASTA scores: opt: 401, E(): 2e-18, (37.7% identity in 244 aa overlap); Q9K4A5|SC7E4.11 HYPOTHETICAL 30.8 KDA PROTEIN from Streptomyces coelicolor (271 aa), FASTA scores: opt: 383,E(): 3.3e-17, (39.6% identity in 283 aa overlap); etc.	Q7TWY5	No	conserved hypotheticals							IPR003738	Q7TWY5	A0A1R3Y3H5				Rv3226c		Rv3226c			
NC_002945.3	Mycobrowser_v4	CDS	3769576	3770364	.	+	0	Mb3433	Mb3433		PROBABLE HYDROLASE	Mb3433, -, len: 262 aa. Equivalent to Rv3400, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Probable hydrolase (EC 3.-.-.-), strongly equivalent to Q49741|YY00_MYCLE|ML0393|B1620_F3_119 HYPOTHETICAL 28.6 KDA PROTEIN from Mycobacterium leprae (261 aa), FASTA scores: opt: 1293, E(): 2.2e-71, (74.45% identity in 262 aa overlap). Similar to several various proteins (notably hydrolases) e.g. Q9L2I7|SCF42.32 PUTATIVE HYDROLASE from Streptomyces coelicolor (246 aa), FASTA scores: opt: 888,E(): 7.7e-47, (56.35% identity in 245 aa overlap); Q9EX06|2SCG38.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (238 aa), FASTA scores: opt: 195, E(): 8.1e-05,(29.5% identity in 234 aa overlap); Q9I5X4|PA0562 PROBABLE HYDROLASE from Pseudomonas aeruginosa (224 aa), FASTA scores: opt: 190, E(): 0.00015, (27.8% identity in 248 aa overlap); O06995|PGMB_BACSU|YVDM PUTATIVE BETA-PHOSPHOGLUCOMUTASE from Bacillus subtilis (226 aa),FASTA scores: opt: 190, E(): 0.00016, (33.9% identity in 245 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),FASTA scores: opt: 413, E(): 2e-17, (34.9% identity in 238 aa overlap). Interestingly, note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle.	X2BNW1,P65070	No	intermediary metabolism and respiration								X2BNW1,P65070	P65070				Rv3400		Rv3400			
NC_002945.3	Mycobrowser_v4	CDS	3559325	3560317	.	+	0	Mb3257	Mb3257		CONSERVED HYPOTHETICAL PROTEIN	Mb3257, -, len: 330 aa. Equivalent to Rv3228, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Conserved hypothetical protein, equivalent to Q9CCI4|ML0791 HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa),FASTA scores: opt: 1828, E(): 1e-98, (84.0% identity in 331 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces coelicolor (337 aa), FASTA scores: opt: 1051, E(): 1e-53,(52.65% identity in 338 aa overlap); Q9HUL3|PA4952 from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 392 ,E(): 1.4e-15, (34.85% identity in 281 aa overlap); Q9PFV1|XF0556 from Xylella fastidiosa (341 aa), FASTA scores: opt: 367, E(): 4e-14, (36.85% identity in 247 aa overlap); P45339|YJEQ_HAEIN|HI1714 from Haemophilus influenzae (346 aa), FASTA scores: opt: 355, E(): 2e-13,(31.65% identity in 281 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A.	Q7TWY3	No	conserved hypotheticals							IPR004881,IPR010914,IPR027417	Q7TWY3	A0A1R3Y447				Rv3228		Rv3228			
NC_002945.3	Mycobrowser_v4	CDS	3561711	3562853	.	-	0	Mb3259c	Mb3259c		HYPOTHETICAL OXIDOREDUCTASE	Mb3259c, -, len: 380 aa. Equivalent to Rv3230c,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Putative oxidoreductase (EC 1.-.-.-), with some similarity to various proteins, especially reductases e.g. Q9HUS4|PA4889 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (366 aa), FASTA scores: opt: 516, E(): 1.8e-24, (33.8% identity in 367 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from Pseudomonas putida (337 aa), FASTA scores: opt: 380,E(): 4e-16, (30.7% identity in 277 aa overlap); BAB34381|ECS0958 NADH OXIDOREDUCTASE FOR THE HCP from Escherichia coli strain O157:H7 (322 aa), FASTA scores: opt: 369, E(): 1.8e-15, (28.65% identity in 328 aa overlap); Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter sp. (336 aa), FASTA scores: opt: 305, E(): 1.6e-11, (27.4% identity in 303 aa overlap); etc.	Q7TWY1	No	intermediary metabolism and respiration							IPR001041,IPR001221,IPR001433,IPR001709,IPR008333,IPR012675,IPR017927,IPR017938	Q7TWY1	A0A1R3Y3U8				Rv3230c		Rv3230c			
NC_002945.3	Mycobrowser_v4	CDS	3562963	3563472	.	-	0	Mb3260c	Mb3260c		conserved protein	Mb3260c, -, len: 169 aa. Equivalent to Rv3231c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Hypothetical protein,only similar to Q9KYX9|SCE33.03c HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap).	Q7TWY0	No	conserved hypotheticals								Q7TWY0	A0A1R3Y3J0				Rv3231c		Rv3231c			
NC_002945.3	Mycobrowser_v4	CDS	3566559	3567716	.	-	0	Mb3264c	Mb3264c		PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN	Mb3264c, -, len: 385 aa. Equivalent to Rv3236c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Probable conserved integral membrane transport protein, possibly cation (Na/H) transporter, equivalent to Q9CCI5|ML0782 putative transmembrane transport protein from Mycobacterium leprae (385 aa), FASTA scores: opt: 1975, E(): 2.4e-108, (81.55% identity in 385 aa overlap). Highly similar to others e.g. O69958|SC4H2.03c putative transmembrane transport protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 1226, E(): 1.6e-64, (53.5% identity in 372 aa overlap); Q9XAKO|SC66T3.13c putative transmembrane transport protein from Streptomyces coelicolor (403 aa), FASTA scores: opt: 1198, E(): 6.8e-63, (53.25% identity in 370 aa overlap); Q9RV80|DR1149 putative Na+/H+ antiporter from Deinococcus radiodurans (383 aa), FASTA scores: opt: 1069, E(): 2.3e-55, (47.35% identity in 376 aa overlap); Q9L191|SC10G8.11 putative transmembrane transport protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 695, E(): 1.9e-33, (38.05% identity in 384 aa overlap); Q9RRW8|DR2367 putative glutathione-regulated potassium-efflux system protein KEFB from Deinococcus radiodurans (575 aa), FASTA scores: opt: 414, E(): 6.2e-17, (30.25% identity in 380 aa overlap); etc. SEEMS TO BELONG TO THE CPA2 FAMILY. Note that previously known as kefB.	Q7TWX6	No	cell wall and cell processes							IPR006153	Q7TWX6	A0A1R3Y3I8				Rv3236c		Rv3236c			
NC_002945.3	Mycobrowser_v4	CDS	3723040	3723333	.	-	0	Mb3390c	Mb3390c		probable integral membrane protein	Mb3390c, -, len: 97 aa. Equivalent to Rv3355c, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Hypothetical protein,equivalent to O32878|MLCB1779.16c|ML0675 HYPOTHETICAL 9.6 KDA PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 439, E(): 3.9e-23, (78.9% identity in 90 aa overlap). Identical, but with a gap, to O50377|Rv3346c|MTV004.02c HYPOTHETICAL 8.9 KDA PROTEIN from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 413, E(): 2.1e-21, (85.55% identity in 97 aa overlap). Also some similarity to other proteins e.g. Q9K3J5|SC2A6.10 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (178 aa), FASTA scores: opt: 147,E(): 0.003, (31.25% identity in 80 aa overlap).	Q7TWN1	No	cell wall and cell processes							IPR021385	Q7TWN1	A0A1R3Y3Z7				Rv3355c		Rv3355c			
NC_002945.3	Mycobrowser_v4	CDS	3567721	3568203	.	-	0	Mb3265c	Mb3265c		conserved protein	Mb3265c, -, len: 160 aa. Equivalent to Rv3237c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Conserved hypothetical protein, equivalent to Q9CCI6|ML0781 HYPOTHETICAL PROTEIN from Mycobacterium leprae (160 aa),FASTA scores: opt: 828, E(): 1.5e-45, (80.6% identity in 160 aa overlap); and similar to other hypothetical bacterial proteins and more weakly to putative potassium channels e.g. Q9RV81|DR1148 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (175 aa), FASTA scores: opt: 420, E(): 9.5e-20, (37.95% identity in 158 aa overlap); O69959|SC4H2.04c HYPOTHETICAL 17.1 KDA PROTEIN from Streptomyces coelicolor (161 aa), FASTA scores: opt: 315,E(): 3.8e-13, (40.0% identity in 150 aa overlap); Q9HNH3|PCHB|VNG2104G POTASSIUM CHANNEL HOMOLOG from Halobacterium sp. strain NRC-1 (418 aa), FASTA scores: opt: 158, E(): 0.007, (31.45% identity in 124 aa overlap); Q58752|YD57_METJA|MJ1357 PUTATIVE POTASSIUM CHANNEL PROTEIN from Methanococcus jannaschii (343 aa), FASTA scores: opt: 143, E(): 0.053, (33.8% identity in 68 aa overlap).	Q7TWX5	No	conserved hypotheticals							IPR006037,IPR026278	Q7TWX5	A0A1R3Y3J1				Rv3237c		Rv3237c			
NC_002945.3	Mycobrowser_v4	CDS	3568264	3568998	.	-	0	Mb3266c	Mb3266c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3266c, -, len: 244 aa. Equivalent to Rv3238c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Probable conserved integral membrane protein, similar to several hypothetical proteins and transmembrane proteins e.g. Q9UN92|NRM29 MULTISPANNING NUCLEAR ENVELOPE MEMBRANE PROTEIN NURIM (FRAGMENT) from Homo sapiens (Human) (261 aa), FASTA scores: opt: 281, E(): 3.3e-11, (30.7% identity in 189 aa overlap); Q9VEG9|CG7655 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (253 aa), FASTA scores: opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa overlap); BAB48937|MLR1600 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (222 aa), FASTA scores: opt: 137, E(): 0.066, (28.1% identity in 185 aa overlap); BAB57936|SAV1774 AESENICAL PUMP MEMBRANE PROTEIN HOMOLOG from Staphylococcus aureus subsp. aureus Mu50 (430 aa), FASTA scores: opt: 125, E(): 0.68, (25.7% identity in 144 aa overlap); etc.	Q7TWX4	No	cell wall and cell processes							IPR009915	Q7TWX4	A0A1R3Y5B6				Rv3238c		Rv3238c			
NC_002945.3	Mycobrowser_v4	CDS	3569057	3572203	.	-	0	Mb3267c	Mb3267c		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN	Mb3267c, -, len: 1048 aa. Equivalent to Rv3239c,len: 1048 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1048 aa overlap). Probable conserved transmembrane protein, organised in two domains. Domain comprising first ~500 aa residues is similar to various antibiotic resistance and efflux proteins and contains sugar transport proteins signature 1 (PS00216); e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 905, E(): 3.1e-41, (36.95% identity in 482 aa overlap); and O68912|FRNF PUTATIVE ANTIBIOTIC ANTIPORTER from Streptomyces roseofulvus (517 aa), FASTA scores: opt: 866, E(): 4.1e-39, (37.1% identity in 512 aa overlap). Second part, corresponding to last 550 aa residues, is very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kd protein from Mycobacterium tuberculosis (583 aa),FASTA scores: E(): 2.1e-28, (36.5% identity in 572 aa overlap). Also equivalent to Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN (SIMILAR TO SUGAR TRANSPORTER FAMILY) from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 4328, E(): 0, (64.15% identity in 1046 aa overlap); and similar to other Mycobacterium tuberculosis proteins: MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E(): 6.3e-32; MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E(): 2.5e-26. Equivalent to AAK47679 Drug transporter from Mycobacterium tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa. Contains cyclic nucleotide-binding domain signature 2 (PS00889). Probably member of major facilitator superfamily (MFS).	Q7TWX3	No	cell wall and cell processes							IPR000595,IPR001411,IPR001423,IPR002641,IPR004638,IPR005829,IPR011701,IPR014710,IPR016035,IPR016196,IPR018488,IPR018490,IPR020846	Q7TWX3	A0A1R3Y472				Rv3239c		Rv3239c			
NC_002945.3	Mycobrowser_v4	CDS	3668187	3668831	.	-	0	Mb3359c	Mb3359c		HYPOTHETICAL PROTEIN	Mb3359c, -, len: 214 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but similar to 3' end of MT3429, len: 172 aa, from Mycobacterium tuberculosis strain CDC1551, (100% identity in 172 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv.	Q7TWQ2	No									Q7TWQ2	A0A1R3Y435									
NC_002945.3	Mycobrowser_v4	CDS	3575210	3575854	.	-	0	Mb3269c	Mb3269c		conserved protein	Mb3269c, -, len: 214 aa. Equivalent to Rv3241c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical protein, similar to many hypothetical proteins and to some putative ribosomal proteins e.g. Q9CCI7|ML0778 HYPOTHETICAL PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1234, E(): 1.3e-72,(89.3% identity in 206 aa overlap); Q9KYX2|SCE33.11c HYPOTHETICAL 27.9 KDA PROTEIN from Streptomyces coelicolor (254 aa), FASTA scores: opt: 487, E(): 2.2e-24, (47.6% identity in 210 aa overlap); Q9FLV3 PROTEIN SIMILAR TO RIBOSOMAL PROTEIN 30S SUBUNIT from Arabidopsis thaliana (Mouse-ear cress) (365 aa), FASTA scores: opt: 264, E(): 7e-10, (26.4% identity in 212 aa overlap); P19954|RR30_SPIOL|RPS22 PLASTID-SPECIFIC 30S RIBOSOMAL PROTEIN 1, chloroplast, from Spinacia oleracea (Spinach) (302 aa), FASTA scores: opt: 261, E(): 9.3e-10, (26.15% identity in 214 aa overlap); P47995|YSEA_STACA HYPOTHETICAL PROTEIN IN SECA 5'REGION (ORF1) (FRAGMENT) (BELONGS TO THE S30AE FAMILY OF RIBOSOMAL PROTEINS) from Staphylococcus carnosus (165 aa), FASTA scores: opt: 201,E(): 4.2e-06, (33.35% identity in 147 aa overlap); etc.	Q7TWX2	No	information pathways							IPR003489	Q7TWX2	A0A1R3Y3V1				Rv3241c		Rv3241c			
NC_002945.3	Mycobrowser_v4	CDS	3576170	3576811	.	-	0	Mb3270c	Mb3270c		CONSERVED HYPOTHETICAL PROTEIN	Mb3270c, -, len: 213 aa. Equivalent to Rv3242c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Conserved hypothetical protein, highly similar in N-terminus to Q9CCI9|ML0776 HYPOTHETICAL PROTEIN from Mycobacterium leprae (85 aa), FASTA scores: opt: 324, E(): 1.7e-13,(78.1% identity in 64 aa overlap). Also similar to Q9RUJ7|DR1389 PUTATIVE COMPETENCE PROTEIN COMF from Deinococcus radiodurans (219 aa), FASTA scores: opt: 223,E(): 6.3e-07, (35.8% identity in 215 aa overlap); BAB50338|MLL3453 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (240 aa), FASTA scores: opt: 218,E(): 1.4e-06, (28.5% identity in 224 aa overlap); Q9A9Y1|CC0830 COMPETENCE PROTEIN F from Caulobacter crescentus (265 aa), FASTA scores: opt: 182, E(): 0.00026,(30.15% identity in 219 aa overlap); etc. Equivalent to AAK47682 from Mycobacterium tuberculosis strain CDC1551 (241 aa) but shorter 29 aa. Contains purine/pyrimidine phosphoribosyl transferases signature (PS00103). SEEMS TO BELONG TO PURINE/PYRIMIDINE PHOSPHORIBOSYL TRANSFERASE FAMILY.	Q7TWX1	No	conserved hypotheticals								Q7TWX1	A0A1R3Y3J7				Rv3242c		Rv3242c			
NC_002945.3	Mycobrowser_v4	CDS	3770379	3772739	.	+	0	Mb3434	Mb3434		conserved protein	Mb3434, -, len: 786 aa. Equivalent to Rv3401, len: 786 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 786 aa overlap). Hypothetical conserved protein, may be an hydrolase or a transferase, equivalent to Q49736|ML0392|B1620_F1_30 HYPOTHETICAL 88.1 KDA PROTEIN from Mycobacterium leprae (792 aa), FASTA scores: opt: 4820, E(): 0, (91.45% identity in 782 aa overlap). Also highly similar to Q9L2I8|SCF42.31c PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (792 aa), FASTA scores: opt: 3060, E(): 2.9e-179, (59.25% identity in 785 aa overlap); and similar to others e.g. Q9K109|NMB0390 MALTOSE PHOSPHORYLASE from Neisseria meningitidis (serogroup B) (752 aa), FASTA scores: opt: 980, E(): 3.5e-52, (29.2% identity in 774 aa overlap); Q9JSW8|MAPA|NMA2098 PUTATIVE MALTOSE PHOSPHORYLASE (EC 2.4.1.8) from Neisseria meningitidis (serogroup A) (752 aa), FASTA scores: opt: 956, E(): 1e-50, (28.4% identity in 764 aa overlap); O06993|YVDK_BACSU HYPOTHETICAL 88.3 KDA PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from Bacillus subtilis (757 aa), FASTA scores: opt: 926,E(): 6.9e-49, (28.5% identity in 754 aa overlap); Q9CF04|MAPA MALTOSEPHOSPHORYLASE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (751 aa), FASTA scores: opt: 907, E(): 1e-47, (26.95% identity in 753 aa overlap); P77154|YCJT_ECOLI|B1316 HYPOTHETICAL 84.9 KDA PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from Escherichia coli strain K12 (755 aa), FASTA scores: opt: 392, E(): 2.9e-16, (27.5% identity in 774 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),(27.2% identity in 802 aa overlap); note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle.	Q7TWJ7	No	intermediary metabolism and respiration							IPR005194,IPR005195,IPR005196,IPR008928,IPR011013,IPR012341,IPR017045	Q7TWJ7	A0A1R3Y442				Rv3401		Rv3401			
NC_002945.3	Mycobrowser_v4	CDS	3584352	3584987	.	-	0	Mb3277c	Mb3277c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3277c, -, len: 211 aa. Equivalent to Rv3249c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Possible transcriptional regulatory protein, tetR family, with similarity to several e.g. Q9AE61|ALKB1 PUTATIVE TETR-REGULATORY from Rhodococcus erythropolis (208 aa),FASTA scores: opt: 503, E(): 7.7e-26, (40.6% identity in 192 aa overlap); CAC37620 PUTATIVE TETR-REGULATORY PROTEIN from Prauserella rugosa (212 aa), FASTA scores: opt: 246,E(): 4.4e-09, (27.95% identity in 186 aa overlap); Q9K4B0|SC7E4.06 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (203 aa), FASTA scores: opt: 224,E(): 1.1e-07, (34.5% identity in 197 aa overlap); Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.27 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 191, E(): 1.6e-05, (28.35% identity in 180 aa overlap); etc. Equivalent to AAK47689 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 19 aa. COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Possible helix-turn helix motif at aa 44-65 (+6.66 SD).	Q7TWW6	No	regulatory proteins							IPR001647,IPR009057,IPR015893	Q7TWW6	A0A1R3Y488				Rv3249c		Rv3249c			
NC_002945.3	Mycobrowser_v4	CDS	3588275	3589663	.	+	0	Mb3282	Mb3282		CONSERVED HYPOTHETICAL PROTEIN	Mb3282, -, len: 462 aa. Equivalent to Rv3254, len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Conserved hypothetical protein, similar to CAC37877|SC1G7.02 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (440 aa), FASTA scores: opt: 606, E(): 6.2e-31, (31.7% identity in 445 aa overlap); O86550|SC1F2.13c HYPOTHETICAL 50.7 KDA PROTEIN from Streptomyces coelicolor (476 aa),FASTA scores: opt: 577, E(): 4.5e-29, (32.5% identity in 400 aa overlap); Q9L0A8|SCC24.09 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (468 aa), FASTA scores: opt: 380, E(): 1.3e-16, (30.7% identity in 391 aa overlap); BAB48792|MLL1411 PROBABLE FAD-DEPENDENT MONOOXYGENASE from Rhizobium loti (Mesorhizobium loti) (421 aa), FASTA scores: opt: 128, E(): 1.1, (25.2% identity in 397 aa overlap); Q9L7X9|BENF BENZOATE-SPECIFIC PORIN-LIKE PROTEIN from Pseudomonas putida (397 aa), FASTA scores: opt: 119,E(): 4, (24.85% identity in 157 aa overlap); etc. Also similar to N-terminus of AAK46259|MT1987 PUTATIVE FERREDOXIN REDUCTASE, ELECTRON TRANSFER COMPONENT from Mycobacterium tuberculosis strain CDC1551 (839 aa), FASTA scores: opt: 493, E(): 1.5e-23, (30.65% identity in 382 aa overlap).	Q7TWW1	No	conserved hypotheticals								Q7TWW1	A0A1R3Y3K5				Rv3254		Rv3254			
NC_002945.3	Mycobrowser_v4	CDS	2489499	2489735	.	-	0	Mb2261A	Mb2261A		Conserved protein	Mb2261A, len: 78 aa. Equivalent to Rv2237A len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 78 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved protein.	X2BKJ1,A0A1R3Y0N1	No	conserved hypotheticals			A0A1R3Y0N1					X2BKJ1					Rv2237A		Rv2237A			
NC_002945.3	Mycobrowser_v4	CDS	3586697	3588184	.	-	0	Mb3281c	Mb3281c		POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN	Mb3281c, -, len: 495 aa. Equivalent to Rv3253c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Possible cationic amino acid transporter, integral membrane protein, similar to many e.g. O69844|SC1C3.02 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Streptomyces coelicolor (503 aa), FASTA scores: opt: 1649, E(): 5.8e-92, (52.6% identity in 485 aa overlap); Q9AE69 PUTATIVE TRANSPORTER (FRAGMENT) from Rhodococcus erythropolis (385 aa), FASTA scores: opt: 1594, E(): 9.7e-89, (62.0% identity in 387 aa overlap); Q9PBD7|XF2207 CATIONIC AMINO ACID TRANSPORTER from Xylella fastidiosa (483 aa), FASTA scores: opt: 1079, E(): 1.2e-57, (40.55% identity in 493 aa overlap); Q9SRU9|F20H23.25 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Arabidopsis thaliana (Mouse-ear cress) (614 aa),FASTA scores: opt: 802, E(): 6.7e-41, (36.4% identity in 445 aa overlap); P30823|CTR1_RAT|SLC7A1|ATRC1 HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 from Rattus norvegicus (Rat) (624 aa), FASTA scores: opt: 782,E(): 1.1e-39, (36.1% identity in 432 aa overlap); etc. Relatives in Mycobacterium tuberculosis include: MTCY3G12.14, E(): 5.6e-31; MTCY39.19, E(): 1.6e-14. SEEMS TO BELONG TO THE APC FAMILY.	Q7TWW2	No	cell wall and cell processes							IPR002293	Q7TWW2	A0A1R3Y3L9				Rv3253c		Rv3253c			
NC_002945.3	Mycobrowser_v4	CDS	3590875	3591915	.	-	0	Mb3284c	Mb3284c		conserved protein	Mb3284c, -, len: 346 aa. Equivalent to Rv3256c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Conserved hypothetical protein, equivalent to Q9CCJ6|ML0764 HYPOTHETICAL PROTEIN from Mycobacterium leprae (365 aa),FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012,(31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap).	Q7TWV9	No	conserved hypotheticals								Q7TWV9	A0A1R3Y3K7				Rv3256c		Rv3256c			
NC_002945.3	Mycobrowser_v4	CDS	3604008	3604697	.	+	0	Mb3296	Mb3296		CONSERVED HYPOTHETICAL PROTEIN	Mb3296, -, len: 229 aa. Equivalent to Rv3268, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Conserved hypothetical protein, similar to Q9KZK4|SCE34.22 HYPOTHETICAL 27.1 KDA PROTEIN from Streptomyces coelicolor (263 aa), FASTA scores: opt: 442, E(): 5.9e-20, (40.1% identity in 242 aa overlap). Also weak similarity to N-terminal part (approximatively 1530 to 1740 residues) of O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 159, E(): 0.11, (30.35% identity in 224 aa overlap).	Q7TWU8	No	conserved hypotheticals							IPR017523	Q7TWU8	A0A1R3Y5G3				Rv3268		Rv3268			
NC_002945.3	Mycobrowser_v4	CDS	3795344	3796507	.	-	0	IS1540-2	IS1540-2		POSSIBLE TRANSPOSASE	Mb3460c, -, len: 387 aa. Equivalent to Rv3430c,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Possible IS1540 transposase, similar to several e.g. Q49592 transposase from Mycobacterium intracellulare (340 aa), FASTA scores: opt: 1377, E(): 1.6e-81, (64.2% identity in 338 aa overlap); similarity is lost at C-terminus due to possible frameshift after aa 297.	Q7TWI9	No	insertion seqs and phages							IPR001584,IPR012337	Q7TWI9					Rv3430c		Rv3430c			
NC_002945.3	Mycobrowser_v4	CDS	3593411	3593902	.	-	0	Mb3286c	Mb3286c		CONSERVED HYPOTHETICAL PROTEIN	Mb3286c, -, len: 163 aa. Equivalent to Rv3258c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein, equivalent to Q9CCJ8|ML0762 HYPOTHETICAL PROTEIN from Mycobacterium leprae (165 aa),FASTA scores: opt: 840, E(): 9.9e-42, (76.9% identity in 169 aa overlap). Also similar to Q9KZL4|SCE34.11c HYPOTHETICAL 15.0 KDA PROTEIN from Streptomyces coelicolor (140 aa), FASTA scores: opt: 353, E(): 1.1e-13, (48.3% identity in 147 aa overlap); and shows really weak similarity to other bacterial proteins.	Q7TWV7	No	conserved hypotheticals							IPR021888	Q7TWV7	A0A1R3Y5E7				Rv3258c		Rv3258c			
NC_002945.3	Mycobrowser_v4	CDS	3722637	3723026	.	+	0	Mb3389	Mb3389		CONSERVED HYPOTHETICAL PROTEIN	Mb3389, -, len: 129 aa. Equivalent to Rv3354, len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 129 aa overlap). Conserved hypothetical protein, equivalent (but shorter 29 aa) to Q9CCM4|ML0676 HYPOTHETICAL PROTEIN from Mycobacterium leprae (158 aa),FASTA scores: opt: 467, E(): 3.3e-21, (55.9% identity in 127 aa overlaps). Highly similar to O33192|LPRJ|Rv1690|MTCI125.12 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (127 aa), FASTA scores: opt: 329, E(): 4.7e-13, (46.95% identity in 115 aa overlap); and also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O07222|Rv1810|MTCY16F9.04c (118 aa), FASTA scores: opt: 195, E(): 4.2e-05, (37.15% identity in 113 aa overlap); MTCI125_11, MTCY16F9_4,MTV049_25.	Q7TWN2	No	conserved hypotheticals							IPR007969	Q7TWN2	A0A1R3Y459				Rv3354		Rv3354			
NC_002945.3	Mycobrowser_v4	CDS	4069865	4070866	.	+	0	Mb3716	Mb3716		conserved protein	Mb3716, -, len: 333 aa. Equivalent to Rv3691, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 333 aa overlap). Conserved hypothetical protein, similar to Q9KYW4|SCE33.19 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (387 aa) FASTA scores: opt: 481, E(): 6e-23, (36.6% identity in 358 aa overlap). Equivalent to AAK48160 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 48 aa.	Q7TVX4	No	conserved hypotheticals							IPR025646	Q7TVX4	A0A1R3Y4X1				Rv3691		Rv3691			
NC_002945.3	Mycobrowser_v4	CDS	3597777	3599438	.	+	0	Mb3291	Mb3291		PROBABLE DNA METHYLASE (MODIFICATION METHYLASE) (METHYLTRANSFERASE)	Mb3291, -, len: 553 aa. Equivalent to Rv3263, len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 553 aa overlap). Probable DNA methylase (EC 2.1.1.-), equivalent to Q9CCK4|ML0756 PROBABLE DNA METHYLASE from Mycobacterium leprae (555 aa),FASTA scores: opt: 2980, E(): 2.1e-184, (81.9% identity in 541 aa overlap). Also similar to others e.g. P25240|MT57_ECOLI|ECO57IM MODIFICATION METHYLASE from Escherichia coli (544 aa), FASTA scores: opt: 595, E(): 1e-30, (30.35% identity in 507 aa overlap); P25201|MTA1_ACICA|ACCIM MODIFICATION METHYLASE ACCI from Acinetobacter calcoaceticus (540 aa), FASTA scores: opt: 366, E(): 5.7e-16, (23.35% identity in 467 aa overlap); Q56752|M-ACCI ACCI METHYLASE from Bergeyella zoohelcum (541 aa), FASTA scores: opt: 365, E(): 6.6e-16, (22.95% identity in 466 aa overlap); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Alternative start site at aa 25.	Q7TWV2	No	information pathways							IPR002052,IPR002296	Q7TWV2	A0A1R3Y3M1				Rv3263		Rv3263			
NC_002945.3	Mycobrowser_v4	CDS	3607267	3607935	.	-	0	Mb3299c	Mb3299c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3299c, -, len: 222 aa. Equivalent to Rv3271c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable conserved integral membrane protein, similar to others e.g. Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa),FASTA scores: opt: 360, E(): 4.7e-16, (33.85% identity in 195 aa overlap); Q9X897|SCE2.02c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 357, E(): 7.3e-16,(33.85% identity in 195 aa overlap); Q9D0E0 2610024A01RIK PROTEIN from Mus musculus (Mouse) (288 aa), FASTA scores: opt: 191, E(): 3.7e-05, (23.65% identity in 207 aa overlap).	Q7TWU6	No	cell wall and cell processes							IPR002524,IPR026765,IPR027469	Q7TWU6	A0A1R3Y3X5				Rv3271c		Rv3271c			
NC_002945.3	Mycobrowser_v4	CDS	3602473	3603969	.	+	0	Mb3295	Mb3295		conserved protein (cpsa-related protein)	Mb3295, -, len: 498 aa. Equivalent to Rv3267, len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 498 aa overlap). Conserved hypothetical protein, CPSA-related protein, equivalent to Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FASTA scores: opt: 2523, E(): 5e-138,(78.9% identity in 498 aa overlap); and Q50160|CPSA (HYPOTHETICAL PROTEIN CPSA) from Mycobacterium leprae (516 aa), FASTA scores: opt: 868, E(): 1.2e-42, (34.7% identity in 507 aa overlap). Also similar to O06347|CPSA|Rv3484|MTCY13E12.37 CPSA from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 928, E(): 4.2e-46, (37.35% identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c HYPOTHETICAL 72.9 KDA PROTEIN from Mycobacterium tuberculosis (684 aa), FASTA scores: opt: 434, E(): 1.5e-17, (30.9% identity in 541 aa overlap). Also similar to Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (507 aa), FASTA scores: opt: 437, E(): 8.1e-18, (28.55% identity in 469 aa overlap); O68907 FRNA PROTEIN from Streptomyces roseofulvus (770 aa), FASTA scores: opt: 388,E(): 7.6e-15, (32.6% identity in 267 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A.	Q7TWU9	No	conserved hypotheticals							IPR004474,IPR027381	Q7TWU9	A0A1R3Y3M3				Rv3267		Rv3267			
NC_002945.3	Mycobrowser_v4	CDS	3604822	3605103	.	+	0	Mb3297	Mb3297		conserved protein	Mb3297, -, len: 93 aa. Equivalent to Rv3269, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, similar to many Mycobacterium proteins and chaperonins/heat shock proteins e.g. Q9CCL0|ML0748 HYPOTHETICAL PROTEIN from Mycobacterium leprae (92 aa),FASTA scores: opt: 427, E(): 6.8e-21, (73.65% identity in 91 aa overlap); Q10865|Rv1993c|MT2049|MTCY39.26c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (90 aa), FASTA scores: opt: 313, E(): 1.2e-13, (60.7% identity in 84 aa overlap); P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c (98 aa), FASTA scores: opt: 294, E(): 2.2e-12, (55.1% identity in 98 aa overlap); Q50827|MOPA|GROEL|CH60_MYCVA CHAPERONIN (PROTEIN CPN60) from Mycobacterium vaccae (120 aa), FASTA scores: opt: 107, E(): 2.1, (39.5% identity in 81 aa overlap); Q9AEB3|HSP65 HEAT SHOCK PROTEIN (FRAGMENT) from Mycobacterium gadium (122 aa), FASTA scores: opt: 102, E(): 4.4, (38.25% identity in 81 aa overlap); Q49374|CH60_MYCGN|MOPA|GROEL CHAPERONIN (PROTEIN CPN60) from Mycobacterium genavense (120 aa), FASTA scores: opt: 99, E(): 6.8, (40.25% identity in 82 aa overlap); etc.	Q7TWU7	No	virulence, detoxification, adaptation							IPR009963	Q7TWU7	A0A1R3Y4C1				Rv3269		Rv3269			
NC_002945.3	Mycobrowser_v4	CDS	3608036	3609220	.	+	0	Mb3300	Mb3300		CONSERVED HYPOTHETICAL PROTEIN	Mb3300, -, len: 394 aa. Equivalent to Rv3272, len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 394 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. Q9I672|PA0446 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (407 aa),FASTA scores: opt: 643, E(): 6.8e-32, (33.15% identity in 389 aa overlap); Q9RJU8|SCF41.21 PUTATIVE RACEMASE from Streptomyces coelicolor (403 aa), FASTA scores: opt: 541,E(): 1.1e-25, (31.95% identity in 385 aa overlap); O87838|SC8A6.04c PUTATIVE TRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 539, E(): 1.5e-25,(29.95% identity in 395 aa overlap); Q9I563|PA0882 from Pseudomonas aeruginosa (400 aa), FASTA scores: opt: 530,E(): 5.2e-25, (28.8% identity in 396 aa overlap); BAB60328|TVG1215416 L-CARNITINE DEHYDRATASE from Thermoplasma volcanium (399 aa), FASTA scores: opt: 529,E(): 6e-25, (32.9% identity in 383 aa overlap); etc. C-terminus is similar to Q49678|U00012_27|B1308_C3_195 from Mycobacterium leprae (130 aa) (60.0% identity in 115 aa overlap). Also partially similar to MTCY359_7 from M. tuberculosis (778 aa) (29.9% identity in 388 aa overlap).	Q7TWU5	No	conserved hypotheticals							IPR003673,IPR023606	Q7TWU5	A0A1R3Y3M7				Rv3272		Rv3272			
NC_002945.3	Mycobrowser_v4	CDS	3609225	3611519	.	+	0	Mb3301	Mb3301		PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	Mb3301, -, len: 764 aa. Equivalent to Rv3273, len: 764 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 764 aa overlap). Probable transmembrane protein (N-terminal part is hydrophobic) with probable carbonic anhydrase activity (in C-terminal part) (EC 4.2.1.1). Possibly involved in transport of sulfate. Equivalent to Q9CBA3|ML2279 PUTATIVE TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium leprae (496 aa), FASTA scores: opt: 1637, E(): 1.8e-89, (59.15% identity in 487 aa overlap). Similar to various proteins (principally sulfate transporters) e.g. Q9X927|SCH5.25 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (830 aa), FASTA scores: opt: 1325, E(): 8e-71,(40.85% identity in 788 aa overlap); Q9I729|PA0103 PROBABLE SULFATE TRANSPORTER from Pseudomonas aeruginosa (523 aa), FASTA scores: opt: 1015, E(): 1.3e-52, (39.95% identity in 488 aa overlap); Q9KN88|VCA0077 SULFATE PERMEASE FAMILY PROTEIN from Vibrio cholerae (553 aa),FASTA scores: opt: 629, E(): 9.6e-30, (30.95% identity in 423 aa overlap); etc. C-terminal part (aa 550-764) shows similarity to carbonic anhydrase e.g. P27134|CYNT_SYNP7 CARBONIC ANHYDRASE (EC 4.2.1.1) (272 aa), FASTA scores: opt: 350, E(): 8.1e-15, (33.8% identity in 201 aa overlap). Contains PS00704 Prokaryotic-type carbonic anhydrases signature 1. SEEMS TO BELONG TO THE SULP FAMILY.	Q7TWU4	No	intermediary metabolism and respiration							IPR001765,IPR011547,IPR015892	Q7TWU4	A0A1R3Y3N0				Rv3273		Rv3273			
NC_002945.3	Mycobrowser_v4	CDS	3645666	3646145	.	+	0	Mb3332	Mb3332		conserved protein	Mb3332, -, len: 159 aa. Equivalent to Rv3304, len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Hypothetical conserved protein, very similar to Q9CCL6|ML0711 HYPOTHETICAL PROTEIN from Mycobacterium leprae (159 aa),FASTA scores: opt: 1041, E(): 6.1e-62, (91.8% identity in 159 aa overlap); and Q49927|L308_F3_97 from M. leprae (174 aa), FASTA scores: opt: 974, E(): 1.8e-57, (91.2% identity in 149 aa overlap) . Also highly similar to Q9AD81|SCK13.10c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (145 aa), FASTA scores: opt: 615,E(): 7.8e-34, (60.55% identity in 147 aa overlap); and shows some similarity to other various hypotheticals proteins. ORF continues upstream with possible start at 2198 (equivalent to AAK47746 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 53 aa).	Q7TWS3	No	conserved hypotheticals							IPR013024,IPR017939	Q7TWS3	A0A1R3Y3R2				Rv3304		Rv3304			
NC_002945.3	Mycobrowser_v4	CDS	3614466	3615284	.	+	0	Mb3305	Mb3305		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3305, -, len: 271 aa. Equivalent to Rv3277, len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 271 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 49 aa, to Q49673|B1308_C1_121|ML0734 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (228 aa), FASTA scores: opt: 1266,E(): 6.1e-78, (84.2% identity in 228 aa overlap). Also similar to various proteins (principally unknowns) e.g. Q9KZ84|SCE25.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (190 aa), FASTA scores: opt: 197,E(): 3.6e-06, (32.0% identity in 150 aa overlap); BAB50058|MLL3086 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (136 aa), FASTA scores: opt: 176,E(): 6.9e-05, (34.7% identity in 147 aa overlap); O29640|AF0615 HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (129 aa), FASTA scores: opt: 120, E(): 0.38,(23.35% identity in 120 aa overlap); Q9KJU8|GTCA TEICHOIC ACID GLYCOSYLATION PROTEIN from Listeria innocua (145 aa),FASTA scores: opt: 117, E(): 0.67, (23.85% identity in 151 aa overlap); etc. Equivalent to AAK47718 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 16 aa. Contains PS00044 Bacterial regulatory proteins, lysR family signature.	Q7TWU2	No	cell wall and cell processes							IPR007267	Q7TWU2	A0A1R3Y3N7				Rv3277		Rv3277			
NC_002945.3	Mycobrowser_v4	CDS	3615239	3615757	.	-	0	Mb3306c	Mb3306c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3306c, -, len: 172 aa. Equivalent to Rv3278c,len: 172 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 172 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CCL2|ML0733 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (172 aa), FASTA scores: opt: 1024, E(): 6e-61, (83.15% identity in 172 aa overlap); and Q49672|B1308_F2_67 HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 1024, E(): 6.3e-61, (83.15% identity in 172 aa overlap) (this is certainly the same putative protein but with N-terminus longer). Also some similarity to other hypothetical proteins (generally membrane proteins) e.g. O26822|MTH726 HYPOTHETICAL PROTEIN from Methanobacterium thermoautotrophicum (204 aa), FASTA scores: opt: 147, E(): 0.0079, (24.6% identity in 187 aa overlap); Q9X8H4|SCE9.01 HYPOTHETICAL 47.7 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (436 aa), FASTA scores: opt: 151, E(): 0.0079,(28.1% identity in 153 aa overlap).	Q7TWU1	No	cell wall and cell processes							IPR005182	Q7TWU1	A0A1R3Y5H1				Rv3278c		Rv3278c			
NC_002945.3	Mycobrowser_v4	CDS	3618744	3619412	.	+	0	Mb3310	Mb3310		CONSERVED HYPOTHETICAL PROTEIN	Mb3310, -, len: 222 aa. Equivalent to Rv3282, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 222 aa overlap). Conserved hypothetical protein, equivalent to Q49670|ML0729 1308R (HYPOTHETICAL PROTEIN ML0729) from Mycobacterium leprae (213 aa), FASTA scores: opt: 945, E(): 5.5e-54, (68.55% identity in 213 aa overlap). Also similar to Q9EWV6|2SCK31.18 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (206 aa), FASTA scores: opt: 459, E(): 1.3e-22, (47.35% identity in 209 aa overlap); P74331|MAF OR SLL0905 MAF PROTEIN from Synechocystis sp. strain PCC 6803 (195 aa),FASTA scores: opt: 401, E(): 6.9e-19, (43.0% identity in 207 aa overlap); and shows weak similarity with various proteins e.g. Q9BUL6 ACETYLSEROTONIN O-METHYLTRANSFERASE-LIKE from Homo sapiens (Human) (621 aa), FASTA scores: opt: 282, E(): 8.9e-11, (31.6% identity in 193 aa overlap); O95671|ASMTL ASMTL PROTEIN from Homo sapiens (Human) (629 aa), FASTA scores: opt: 282, E(): 9e-11, (31.6% identity in 193 aa overlap); BAB51136|MLR4491 MAF PROTEIN from Rhizobium loti (Mesorhizobium loti) (199 aa), FASTA scores: opt: 269,E(): 2.3e-10, (29.3% identity in 198 aa overlap); etc.	X2BMR0,Q7TWT7	No	conserved hypotheticals								X2BMR0,Q7TWT7	Q7TWT7				Rv3282		Rv3282			
NC_002945.3	Mycobrowser_v4	CDS	3805099	3805941	.	+	0	Mb3468	Mb3468		conserved protein	Mb3468, -, len: 280 aa. Equivalent to Rv3438, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, equivalent to Q9CCV6|ML0370 HYPOTHETICAL PROTEIN from Mycobacterium leprae (289 aa),FASTA scores: opt: 1491, E(): 9.2e-81, (79.85% identity in 283 aa overlap); and highly similar (but shorter 41 aa) to Q49872|B229_F1_20 HYPOTHETICAL 34.0 KDA PROTEIN from Mycobacterium leprae (324 aa), FASTA scores: opt: 1491,E(): 1e-80, (79.85% identity in 283 aa overlap). Shows some similarity to Q9KIU3|LIPA LIPASE from plasmid pAH114 uncultured bacterium (281 aa), FASTA scores: opt: 168,E(): 0.0081, (29.3% identity in 140 aa overlap).	Q7TWI2	No	conserved hypotheticals								Q7TWI2	A0A1R3Y4V5				Rv3438		Rv3438			
NC_002945.3	Mycobrowser_v4	CDS	3626853	3628100	.	+	0	Mb3320	Mb3320		CONSERVED HYPOTHETICAL PROTEIN	Mb3320, -, len: 415 aa. Equivalent to Rv3292, len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Conserved hypothetical protein, similar to P76097|YDCJ_ECOLI|B1423 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain K12 (447 aa), FASTA scores: opt: 747, E(): 5.6e-39,(38.55% identity in 449 aa overlap); BAB35451|ECS2028 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain O157:H7 (447 aa), FASTA scores: opt: 744, E(): 8.6e-39,(38.3% identity in 449 aa overlap); AAG56352|Z2297 PROTEIN from Escherichia coli O157:H7 EDL933 (212 aa), FASTA scores: opt: 454, E(): 4.6e-21, (41.75% identity in 206 aa overlap); and similar in part with Q49664|B1308_C1_136 from Mycobacterium leprae (71 aa), FASTA scores: opt: 305,E(): 3.2e-12, (70.0% identity in 70 aa overlap).	X2BMS0	No	conserved hypotheticals								X2BMS0	P65066				Rv3292		Rv3292			
NC_002945.3	Mycobrowser_v4	CDS	3629711	3630520	.	-	0	Mb3322c	Mb3322c		CONSERVED HYPOTHETICAL PROTEIN	Mb3322c, -, len: 269 aa. Equivalent to Rv3294c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 269 aa overlap). Conserved hypothetical protein, similar to several conserved hypothetical proteins from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa), FASTA scores: opt: 682, E(): 3.6e-37, (44.85% identity in 243 aa overlap); O53329|Rv3179 (454 aa), FASTA scores: opt: 561, E(): 3.3e-29, (42.20% identity in 218 aa overlap); Q10849|YK08_MYCTU|Rv2008c (441 aa), FASTA scores: opt: 194, E(): 3.9e-05, (30.10% identity in 239 aa overlap). Also some similarity with proteins from other organisms. Replace previous Rv3294 on opposite strand.	Q7TWT0	No	conserved hypotheticals							IPR025420	Q7TWT0	A0A1R3Y3P9				Rv3294c		Rv3294c			
NC_002945.3	Mycobrowser_v4	CDS	3630591	3631256	.	+	0	Mb3323	Mb3323		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3323, -, len: 221 aa. Equivalent to Rv3295, len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable transcriptional regulator tetR-family, equivalent to Q9CCL4|ML0717 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (223 aa), FASTA scores: opt: 1260, E(): 7.2e-75, (85.45% identity in 220 aa overlap). Also highly similar to other streptomyces regulators e.g. Q9RD77|SCF43.11 from Streptomyces coelicolor (205 aa), FASTA scores: opt: 442, E(): 9.8e-22,(38.6% identity in 202 aa overlap); Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa), FASTA scores: opt: 215,E(): 5.9e-07, (31.85% identity in 135 aa overlap); Q9L0U5|SCD35.06 from Streptomyces coelicolor (240 aa),FASTA scores: opt: 214, E(): 7.4e-07, (28.2% identity in 156 aa overlap); etc. SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Contains potential helix-turn-helix motif at aa 33-54 (+4.42 SD).	Q7TWS9	No	regulatory proteins							IPR001647,IPR009057,IPR015893	Q7TWS9	A0A1R3Y3Q4				Rv3295		Rv3295			
NC_002945.3	Mycobrowser_v4	CDS	3640508	3641425	.	-	0	Mb3328c	Mb3328c		CONSERVED HYPOTHETICAL PROTEIN	Mb3328c, -, len: 305 aa. Equivalent to Rv3300c,len: 305 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 305 aa overlap). Conserved hypothetical protein, similar to various proteins (notably pseudoridine synthase family proteins) e.g. Q9RJ76|SCI41.08 PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 876, E(): 4.5e-48,(52.1% identity in 313 aa overlap); Q9I272|PA2043 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa),FASTA scores: opt: 676, E(): 1.8e-35, (42.55% identity in 268 aa overlap); Q9JZW8|NMB0867 YABO/YCEC/SFHB FAMILY PROTEIN from Neisseria meningitidis (serogroup B) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q9JUY2|NMA1085 HYPOTHETICAL PROTEIN from Neisseria meningitidis (serogroup A) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q12362|RIB2_YEAST|RIB2|YOL066C DRAP DEAMINASE (PSEUDOURIDINE SYNTHASE FAMILY PROTEIN) from Saccharomyces cerevisiae (Baker's yeast) (591 aa), FASTA scores: opt: 338, E(): 6.9e-14, (32.95% identity in 246 aa overlap); Q9RTS2|DR1684 PUTATIVE PSEUDOURIDINE SYNTHASE from Deinococcus radiodurans (321 aa), FASTA scores: opt: 319,E(): 6.5e-13, (32.75% identity in 235 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308 aa) (28.8% identity in 299 aa overlap).	Q7TWS5	No	conserved hypotheticals							IPR006145,IPR006224,IPR020103	Q7TWS5	A0A1R3Y3U6				Rv3300c		Rv3300c			
NC_002945.3	Mycobrowser_v4	CDS	3652646	3653908	.	+	0	Mb3339	Mb3339		conserved protein	Mb3339, -, len: 420 aa. Equivalent to Rv3311, len: 420 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 420 aa overlap). Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical proteins Q9CCL8|ML0703 (423 aa), FASTA scores: opt: 2185, E(): 5.5e-120, (77.55% identity in 423 aa overlap); Q49918|L308_F2_61 (167 aa), FASTA scores: opt: 929, E(): 3.5e-47, (84.4% identity in 167 aa overlap) (similarity at C-terminus for this one); and Q49914|L308_F1_17 (166 aa), FASTA scores: opt: 900, E(): 1.7e-45, (79.0% identity in 162 aa overlap) (similarity at N-terminus for this one); Q49923|U0308N (86 aa) FASTA scores: opt: 149, E(): 0.052, (48.35% identity in 60 aa overlap); etc. Note that the Rv3311 corresponding protein in Mycobacterium leprae is similar to products of two adjacent ORFs. Also some similarity to Q9XI61|F9L1.1 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (523 aa), FASTA scores: opt: 134, E(): 1.8, (25.1% identity in 203 aa overlap). Equivalent to AAK47753 from Mycobacterium tuberculosis strain CDC1551 (431 aa) but shorter 12 aa.	Q7TWR8	No	conserved hypotheticals								Q7TWR8	A0A1R3Y410				Rv3311		Rv3311			
NC_002945.3	Mycobrowser_v4	CDS	3653929	3654855	.	-	0	Mb3340c	Mb3340c		CONSERVED HYPOTHETICAL PROTEIN	Mb3340c, -, len: 308 aa. Equivalent to Rv3312c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Hypothetical protein,similar to various proteins (principally hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (326 aa), FASTA scores: opt: 261, E(): 2.6e-09, (27.55% identity in 323 aa overlap); Q9FWB6 PUTATIVE ALPHA/BETA HYDROLASE from Oryza sativa (Rice) (354 aa), FASTA scores: opt: 241, E(): 4.9e-08, (28.9% identity in 301 aa overlap) (note that Q9FWB6 correspond to Q9FWB5 PUTATIVE ALPHA/BETA HYDROLASE (353 aa) but longer 1 aa; and to Q9AUW9 HYPOTHETICAL PROTEIN (332 aa) but longer 22 aa); Q9M382|F24B22.200 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (342 aa), FASTA scores: opt: 222, E(): 8e-07, (27.6% identity in 319 aa overlap); Q9HWM9|PA4152 PROBABLE HYDROLASE from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 176, E(): 0.00071,(29.2% identity in 209 aa overlap); Q9L3R2 HYDROLASE from Rhizobium leguminosarum (261 aa), FASTA scores: opt: 174,E(): 0.00071, (28.9% identity in 173 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) from Streptomyces lividans (275 aa), FASTA scores: opt: 172, E(): 0.001, (30.9% identity in 194 aa overlap) (similarity only at N-terminus for this one); etc. Some similarity in N-terminal part to non-heme chloroperoxidases. Also similar to O05293|Rv1191|MTCI364.03 HYPOTHETICAL PROTEIN from M. tuberculosis (304 aa), FASTA scores: opt: 417, E(): 3.1e-19, (32.6% identity in 279 aa overlap) (note that Rv1191 is equivalent to AAK45485 from Mycobacterium tuberculosis strain CDC1551 but shorter 14 aa, and that AAK45485 is annoted Hydrolase, alpha/beta hydrolase family).	Q7TWR7	No	conserved hypotheticals								Q7TWR7	A0A1R3Y3T5				Rv3312c		Rv3312c			
NC_002945.3	Mycobrowser_v4	CDS	3666685	3667071	.	+	0	Mb3357	Mb3357		HYPOTHETICAL PROTEIN [SECOND PART]	Mb3357, -, len: 128 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but similar to 3' end of a hypothetical CDS, len: 237 aa, from Mycobacterium tuberculosis strain F4, (100.0% identity in 109 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv.	Q7TWQ4	No									Q7TWQ4	A0A1R3Y4J5									
NC_002945.3	Mycobrowser_v4	CDS	3662960	3663574	.	-	0	Mb3351c	Mb3351c		POSSIBLE METHYLTRANSFERASE	Mb3351c, -, len: 204 aa. Equivalent to Rv3322c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 204 aa overlap). Conserved hypothetical protein, showing weak similarity to proteins including several methyltransferases (EC 2.1.1.-) e.g. Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (208 aa), FASTA scores: opt: 193, E(): 1e-05,(36.35% identity in 132 aa overlap); and Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 161, E(): 0.0014, (32.05% identity in 131 aa overlap); P74712|SLR1183 HYPOTHETICAL 21.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (194 aa), FASTA scores: opt: 155, E(): 0.0032, (27.35% identity in 150 aa overlap); Q9ABW8|CC0102 RRNA METHYLTRANSFERASE RSMB from Caulobacter crescentus (429 aa), FASTA scores: opt: 148, E(): 0.018, (31.5% identity in 162 aa overlap); etc. Also highly similar to O05796|Rv3120|MTCY164.30 HYPOTHETICAL 21.8 KDA PROTEIN from Mycobacterium tuberculosis (200 aa), FASTA scores: opt: 691, E(): 1.2e-38, (56.5% identity in 200 aa overlap); and shows weak similarity to O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE from Mycobacterium tuberculosis (233 aa), FASTA scores: opt: 155, E(): 0.0037, (29.15% identity in 168 aa overlap).	Q7TWQ7	No	intermediary metabolism and respiration								Q7TWQ7	A0A1R3Y3S8				Rv3322c		Rv3322c			
NC_002945.3	Mycobrowser_v4	CDS	3666357	3666707	.	+	0	Mb3356	Mb3356		HYPOTHETICAL PROTEIN [FIRST PART]	Mb3356, -, len: 116 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but similar to 5' end of a hypothetical CDS, len: 237 aa, from Mycobacterium tuberculosis strain F4, (100.0% identity in 109 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv.	Q7TWQ5	No									Q7TWQ5	A0A1R3Y5L8									
NC_002945.3	Mycobrowser_v4	CDS	3668998	3670710	.	+	0	Mb3360	Mb3360		PROBABLE TRANSPOSASE FUSION PROTEIN	Mb3360, -, len: 570 aa. Equivalent to Rv3327, len: 570 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 570 aa overlap). Probable fusion protein. Indeed, N-terminal part corresponds to entire O07269 transposase of IS1547 (383 aa), and C-terminal part identical to MTCI249B.03c (210 aa). N-terminal part is identical to MTV042_7 (188 aa); C-terminal part (aa 378-570) is similar to hypothetical 20.5 KD protein from Escherichia coli P76222|YNJA_ECOLI (182 aa), FASTA scores: opt: 292, E(): 5.3e-11, (32.6% identity in 181 aa overlap).	Q7TWQ1	No	insertion seqs and phages							IPR002525,IPR003346	Q7TWQ1	A0A1R3Y3W4				Rv3327		Rv3327			
NC_002945.3	Mycobrowser_v4	CDS	3671557	3672957	.	+	0	Mb3362	Mb3362		PROBABLE AMINOTRANSFERASE	Mb3362, -, len: 466 aa. Equivalent to hypothetical protein MT3432 from Mycobacterium tuberculosis strain CDC1551 (100% identity with 465 aa overlap). Probable aminotransferase (EC 2.6.1.-), similar to many e.g. O86744|SC6A9.12 from Streptomyces coelicolor (457 aa),Q9I6J2|PA0299 from Pseudomonas aeruginosa (456 aa),Q53196|Y4UB_RHISN from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (467 aa), P33189|YHXA_BACSU from Bacillus subtilis (450 aa) etc. COFACTOR: PYRIDOXAL PHOSPHATE. COULD BELONG TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.	X2BN66	No									X2BN66	A0A1R3Y3V6									
NC_002945.3	Mycobrowser_v4	CDS	3784354	3784764	.	+	0	Mb3446	Mb3446		CONSERVED HYPOTHETICAL PROTEIN	Mb3446, -, len: 136 aa. Equivalent to Rv3412, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Hypothetical protein,strongly similar only to Q49742|YY12_MYCLE|ML0386|B1620_F3_131 HYPOTHETICAL 15.3 KDA PROTEIN from Mycobacterium leprae (137 aa), FASTA scores: opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa overlap).	X2BN69	No	conserved hypotheticals								X2BN69	P65080				Rv3412		Rv3412			
NC_002945.3	Mycobrowser_v4	CDS	3678506	3678946	.	+	0	Mb3367	Mb3367		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MERR-FAMILY)	Mb3367, -, len: 146 aa. Equivalent to Rv3334, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Probable transcriptional regulator, similar to many regulatory proteins (notably mercury resistance operon regulators) e.g. Q9HXV1|PA3689 PROBABLE TRANSCRIPTIONAL REGULATOR MERR FAMILY from Pseudomonas aeruginosa (156 aa), FASTA scores: opt: 275, E(): 1.6e-11, (35.95% identity in 139 aa overlap); Q9AKR6|PBRR LEAD RESISTANCE OPERON REGULATOR from Ralstonia metallidurans strain CH34 (plasmid pMOL30) (145 aa), FASTA scores: opt: 267, E(): 5.2e-11, (35.8% identity in 134 aa overlap); P95838|MERR MERCURIC RESISTANCE OPERON REGULATOR from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (144 aa), FASTA scores: opt: 266, E(): 6e-11, (31.35% identity in 118 aa overlap); P22853|MERR_BACSR MERCURIC RESISTANCE OPERON REGULATOR from Bacillus sp. strain RC607 (132 aa), FASTA scores: opt: 262, E(): 1e-10, (34.6% identity in 130 aa overlap); etc. Contains probable helix-turn-helix motif at aa 1-22 (Score 1478, +4.22 SD). SEEMS TO BELONG TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TWP4	No	regulatory proteins							IPR000551,IPR009061,IPR015358	Q7TWP4	A0A1R3Y4L2				Rv3334		Rv3334			
NC_002945.3	Mycobrowser_v4	CDS	3678980	3679849	.	-	0	Mb3368c	Mb3368c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3368c, -, len: 289 aa. Equivalent to Rv3335c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable conserved integral membrane protein, equivalent to Q49909|ML0687 PUTATIVE MEMBRANE PROTEIN U0308AA from Mycobacterium leprae (313 aa), FASTA scores: opt: 1299, E(): 8.9e-75,(68.75% identity in 288 aa overlap). Also similar to other hypothetical bacterial proteins e.g. BAB37825|ECS4402 from Escherichia coli strain O157:H7 (alias P37642|YHJD_ECOLI|B3522 strain K12) (337 aa), FASTA scores: opt: 591, E(): 4.2e-30, (35.15% identity in 273 aa overlap); P45417|YHJD_ERWCH from Erwinia chrysanthemi (328 aa), FASTA scores: opt: 500, E(): 2.2e-24, (34.9% identity in 275 aa overlap); Q9KZA0|SC5G8.14 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (321 aa),FASTA scores: opt: 321, E(): 4.3e-13, (27.3% identity in 271 aa overlap); etc.	Q7TWP3	No	cell wall and cell processes							IPR005274,IPR017039	Q7TWP3	A0A1R3Y3X1				Rv3335c		Rv3335c			
NC_002945.3	Mycobrowser_v4	CDS	3727100	3727681	.	-	0	Mb3397c	Mb3397c		PROBABLE ATP/GTP-BINDING PROTEIN	Mb3397c, -, len: 193 aa. Equivalent to Rv3362c,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 193 aa overlap). Probable ATP/GTP-binding protein, similar to others from Streptomyces coelicolor e.g. O86519|SC1C2.18c (174 aa),FASTA scores: opt: 731, E(): 9.8e-41, (66.85% identity in 169 aa overlap); Q9XAE1|SC6G9.41c (191 aa), FASTA scores: opt: 730, E(): 1.2e-40, (63.55% identity in 173 aa overlap); Q9L235|SC1A2.06 (184 aa), FASTA scores: opt: 650, E(): 1.9e-35, (55.95% identity in 177 aa overlap); Q9RJ74|SCI41.10c (176 aa), FASTA scores: opt: 618, E(): 2.3e-33, (55.9% identity in 161 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TWM6	No	conserved hypotheticals							IPR004130,IPR027417	Q7TWM6	A0A1R3Y4P7				Rv3362c		Rv3362c			
NC_002945.3	Mycobrowser_v4	CDS	3680905	3681798	.	+	0	Mb3370	Mb3370		CONSERVED HYPOTHETICAL PROTEIN	Mb3370, -, len: 297 aa. Equivalent to Rv3337 and Rv3338, len: 128 aa and 214 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 81 aa overlap and 100.0% identity in 214 aa overlap). Rv3337: Conserved hypothetical protein, equivalent to N-terminus of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: *****opt: 362, E(): 3e-17, (74.3% identity in 70 aa overlap). Also weak similarity in N-terminus to BAB49078|MLR1789 PROBABLE EPOXIDE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (300 aa), FASTA scores: opt: 116, E(): 0.74, (38.9% identity in 54 aa overlap). Homology suggests this ORF should be in frame with the following ORF MTV016.38 but no sequence error could be found. Short distance to start of trpS suggests region may not be protein-coding. C-terminus extended since first submission (+47 aa). Rv3338: Hypothetical protein, equivalent to C-termini of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: opt: 984, E(): 2.6e-56,(65.4% identity in 214 aa overlap); and O32873|MLCB1779.02 HYPOTHETICAL 31.8 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (292 aa), FASTA scores: opt: 984, E(): 2.5e-56, (65.4% identity in 214 aa overlap). Also similar to C-termini of several hypothetical proteins (generally hydrolases) e.g. Q9K3H6|2SCG18.11 PUTATIVE HYDROLASE from Streptomyces coelicolor (316 aa), FASTA scores: opt: 213, E(): 1.4e-06,(29.75% identity in 185 aa overlap). Homology suggests that this ORF should be in frame with the previous ORF MTV016.37 but no sequence error could be found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base insertion (*-t) leads to a single product.	Q7TWP2	No	conserved hypotheticals							IPR000639	Q7TWP2	A0A1R3Y3Y4				Rv3337		Rv3337			
NC_002945.3	Mycobrowser_v4	CDS	4050868	4051689	.	-	0	Mb3696c	Mb3696c		CONSERVED HYPOTHETICAL PROTEIN	Mb3696c, -, len: 273 aa. Equivalent to Rv3672c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Conserved hypothetical protein, equivalent to Q9CB94|ML2299 HYPOTHETICAL PROTEIN from Mycobacterium leprae (266 aa) FASTA scores: opt: 1358, E(): 5.2e-75, (76.4% identity in 267 aa overlap). Also similar to others (generally in C-terminal end) e.g. Q9XA45|SCH17.02c HYPOTHETICAL 26.5 KDA PROTEIN from Streptomyces coelicolor (247 aa) FASTA scores: opt: 524, E(): 1.3e-24, (42.65% identity in 251 aa overlap); Q9AB27|CC0407 MUTT/NUDIX FAMILY PROTEIN from Caulobacter crescentus (216 aa), FASTA scores: opt: 285,E(): 3.2e-10, (36.2% identity in 174 aa overlap); BAB49788|MLL2727|Q98HS8 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (204 aa), FASTA scores: opt: 278, E(): 8.1e-10, (31.45% identity in 151 aa overlap); P43337|YEAB_ECOLI|B1813 HYPOTHETICAL 21.4 KDA PROTEIN from Escherichia coli strain K12 (192 aa) FASTA scores: opt: 252, E(): 2.9e-08, (35.9% identity in 170 aa overlap); etc. Contains PS01293 Uncharacterized protein family UPF0036 signature, LLT.	Q7TVZ2	No	conserved hypotheticals							IPR000059,IPR000086,IPR015797	Q7TVZ2	A0A1R3Y4V2				Rv3672c		Rv3672c			
NC_002945.3	Mycobrowser_v4	CDS	3752375	3753079	.	+	0	Mb3418	Mb3418		POSSIBLE TRANSPOSASE	Mb3418, -, len: 234 aa. Equivalent to Rv3386, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Possible transposase,showing very weak similarity to several IS element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap).	Q7TWK8	No	insertion seqs and phages							IPR008490	Q7TWK8	A0A1R3Y417				Rv3386		Rv3386			
NC_002945.3	Mycobrowser_v4	CDS	3685874	3686605	.	+	0	Mb3374	Mb3374		POSSIBLE METHYLTRANSFERASE (METHYLASE)	Mb3374, -, len: 243 aa. Equivalent to Rv3342, len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 243 aa overlap). Possible methyltransferase (EC 2.1.1.-), similar to various proteins e.g. Q9I5X8|PA0558 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (255 aa), FASTA scores: opt: 496,E(): 4.4e-24, (39.85% identity in 236 aa overlap); Q9XBC9|CZA382.22c PUTATIVE RRNA METHYLASE from Amycolatopsis orientalis (259 aa), FASTA scores: opt: 473,E(): 1.2e-22, (42.45% identity in 245 aa overlap); Q9UTA8|SPAC25B8.10 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (256 aa), FASTA scores: opt: 470, E(): 1.9e-22, (35.7% identity in 238 aa overlap); and Q9UTA9|SPAC25B8.09 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (251 aa), FASTA scores: opt: 418, E(): 3.4e-19,(31.2% identity in 237 aa overlap); etc. Start uncertain. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY.	X2BP79,P65349	No	intermediary metabolism and respiration								X2BP79,P65349	P65349				Rv3342		Rv3342			
NC_002945.3	Mycobrowser_v4	CDS	3720872	3721666	.	-	0	Mb3386c	Mb3386c		CONSERVED HYPOTHETICAL PROTEIN	Mb3386c, -, len: 264 aa. Equivalent to Rv3351c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Hypothetical protein,highly similar to C-terminal region (aa 292-479) of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from M. tuberculosis (479 aa), FASTA scores: opt: 699, E(): 1.7e-36, (54.75% identity in 190 aa overlap). Shows some similarity to Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 192, E(): 9.1e-05, (27.9% identity in 154 aa overlap); and P71091|YGAK HYPOTHETICAL 54.4 KDA PROTEIN from Bacillus subtilis (480 aa), FASTA scores: opt: 174,E(): 0.0014, (26.5% identity in 166 aa overlap). Note that the two upstream ORFs Rv3352c and Rv3353c also show similarity to Rv0063 (MTV030_7). Sequence was checked but no errors found.	Q7TWN5	No	conserved hypotheticals							IPR012951	Q7TWN5	A0A1R3Y5N9				Rv3351c		Rv3351c			
NC_002945.3	Mycobrowser_v4	CDS	3753069	3753746	.	+	0	Mb3419	Mb3419		POSSIBLE TRANSPOSASE	Mb3419, -, len: 225 aa. Equivalent to Rv3387, len: 225 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 225 aa overlap). Possible transposase,showing very weak similarity to other IS element proteins,and similar to various hypothetical proteins.	Q7TWK7	No	insertion seqs and phages								Q7TWK7	A0A1R3Y474				Rv3387		Rv3387			
NC_002945.3	Mycobrowser_v4	CDS	3724870	3726060	.	+	0	Mb3394	Mb3394		POSSIBLE OXIDOREDUCTASE	Mb3394, -, len: 396 aa. Equivalent to Rv3359, len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to N-terminal part of various proteins (hypothetical unknowns or oxidoreductases) e.g. Q9ZB94 HYPOTHETICAL 69.3 KDA PROTEIN from Rhodococcus erythropolis (649 aa), FASTA scores: opt: 509, E(): 3e-24, (30.0% identity in 380 aa overlap); O29991|AF0248 NADH-DEPENDENT FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (378 aa), FASTA scores: opt: 478,E(): 1.6e-22, (32.45% identity in 379 aa overlap); Q9HUH9|PA4986 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (648 aa), FASTA scores: opt: 412, E(): 3.3e-18,(30.45% identity in 384 aa overlap); Q9KCT8|BH1481 NADH OXIDASE from Bacillus halodurans (338 aa), FASTA scores: opt: 404, E(): 6.1e-18, (30.2% identity in 275 aa overlap); etc. Some weak similarity to Mycobacterium leprae MLCB1779_10.	Q7TWM9	No	intermediary metabolism and respiration							IPR001155,IPR013785	Q7TWM9	A0A1R3Y3Z9				Rv3359		Rv3359			
NC_002945.3	Mycobrowser_v4	CDS	3726177	3726545	.	+	0	Mb3395	Mb3395		CONSERVED HYPOTHETICAL PROTEIN	Mb3395, -, len: 122 aa. Equivalent to Rv3360, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical protein,highly similar to the N-terminus of O65934|Rv1747|MTCY28.10|MTCY04C12.31 probable ABC-transporter ATP-binding protein from Mycobacterium tuberculosis (865 aa), FASTA scores: opt: 480, E(): 4.7e-25, (61.0% identity in 118 aa overlap); and some similarity with the N-terminus of P96214|Rv3863|MTCY01A6.05c HYPOTHETICAL 41.1 KDA PROTEIN from Mycobacterium tuberculosis (392 aa), FASTA scores: opt: 138, E(): 0.033, (31.95% identity in 97 aa overlap). Some weak similarity with the N-terminus of other hypothetical proteins e.g. P73823|CYAA|SLR1991 ADENYLATE CYCLASE from Synechocystis sp. strain PCC 6803 (337 aa),FASTA scores: opt: 127, E(): 0.16, (28.55% identity in 112 aa overlap).	Q7TWM8	No	conserved hypotheticals							IPR000253,IPR008984	Q7TWM8	A0A1R3Y3Z5				Rv3360		Rv3360			
NC_002945.3	Mycobrowser_v4	CDS	3726542	3727093	.	-	0	Mb3396c	Mb3396c		conserved protein	Mb3396c, -, len: 183 aa. Equivalent to Rv3361c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, with some similarity to various proteins e.g. P74221|YB52_SYNY3|SLR1152 HYPOTHETICAL 36.2 KDA PROTEIN SLR (CONTAINS 5 PENTAPEPTIDE REPEAT DOMAINS) from Synechocystis sp. strain PCC 6803 (331 aa), FASTA scores: opt: 252, E(): 3.9e-10, (30.55% identity in 167 aa overlap); Q9SE95 FH PROTEIN INTERACTING PROTEIN FIP2 from Arabidopsis thaliana (Mouse-ear cress) (298 aa), FASTA scores: opt: 207, E(): 4.4e-07, (30.35% identity in 168 aa overlap); Q9A735|CC1891 PENTAPEPTIDE REPEAT FAMILY PROTEIN from Caulobacter crescentus (250 aa), FASTA scores: opt: 181, E(): 2.3e-05, (24.05% identity in 187 aa overlap); etc.	Q7TWM7	No	conserved hypotheticals							IPR001646	Q7TWM7	A0A1R3Y5P1				Rv3361c		Rv3361c			
NC_002945.3	Mycobrowser_v4	CDS	3784774	3785673	.	-	0	Mb3447c	Mb3447c		unknown alanine and proline rich protein	Mb3447c, -, len: 299 aa. Equivalent to Rv3413c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Hypothetical unknown ala-, pro-rich protein.	X2BNM8,P65082	No	conserved hypotheticals								X2BNM8,P65082	P65082				Rv3413c		Rv3413c			
NC_002945.3	Mycobrowser_v4	CDS	3733975	3734619	.	-	0	Mb3403c	Mb3403c		POSSIBLE OXIDOREDUCTASE	Mb3403c, -, len: 214 aa. Equivalent to Rv3368c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to O07697|MLCL383.23|ML0418 HYPOTHETICAL 23.6 KDA PROTEIN (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (210 aa), FASTA scores: opt: 1215, E(): 1.5e-74, (81.4% identity in 210 aa overlap). Also similar to O30106|AF0131 PUTATIVE NAD(P)H-FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (194 aa), FASTA scores: opt: 139, E(): 0.028,(29.0% identity in 207 aa overlap); Q60049|NOX_THETH NADH DEHYDROGENASE from Thermus aquaticus (subsp. thermophilus) (205 aa), FASTA scores: opt: 169, E(): 0.00028, (28.3% identity in 212 aa overlap); and shows some similarity to other hypothetical proteins (unknowns or oxidoreductases).	Q7TWM1	No	intermediary metabolism and respiration							IPR000415	Q7TWM1	A0A1R3Y406				Rv3368c		Rv3368c			
NC_002945.3	Mycobrowser_v4	CDS	3728397	3731027	.	-	0	Mb3400c	Mb3400c		conserved protein	Mb3400c, -, len: 876 aa. Equivalent to Rv3365c,len: 876 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 876 aa overlap). Conserved hypothetical protein, similar to various proteins from Streptomyces coelicolor e.g. O86525|SC1C2.25c HYPOTHETICAL 139.7 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1329 aa), FASTA scores: opt: 879, E(): 5.4e-32, (29.9% identity in 924 aa overlap) (similarity in N-terminal part for this one); O86522|SC1C2.21c HYPOTHETICAL 119.9 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1111 aa), FASTA scores: opt: 855, E(): 5.6e-31,(28.9% identity in 892 aa overlap) (similarity in N-terminal part for this one); Q9KZI5|SCG8A.14c PUTATIVE MEMBRANE PROTEIN (862 aa), FASTA scores: opt: 791, E(): 3.3e-28, (30.8% identity in 828 aa overlap); Q9KZN0|SC1A8A.22c (943 aa), FASTA scores: opt: 660, E(): 2.5e-22, (27.65% identity in 893 aa overlap); etc. Similar in part to two consecutive Mycobacterium leprae hypothetical ORFs, probably representing a pseudogene: O07701|MLCL383.27 (118 aa), FASTA scores: opt: 430, E(): 1e-12, (58.25% identity in 115 aa overlap); and O07700|MLCL383.26 (111 aa), FASTA scores: opt: 271, E(): 1.3e-05, (50.4% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.	Q7TVB4	No	conserved hypotheticals							IPR003594,IPR003660	Q7TVB4	A0A1R3Y413				Rv3365c		Rv3365c			
NC_002945.3	Mycobrowser_v4	CDS	3738572	3739912	.	+	0	Mb3406	Mb3406		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb3406, -, len: 446 aa. Equivalent to Rv3371, len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 446 aa overlap). Hypothetical protein,similar to many Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. O07035|YV30_MYCTU|Rv3130c|MTCY03A2.28|MTCY164.41c (463 aa), FASTA scores: opt: 556, E(): 7.7e-28, (44.95% identity in 447 aa overlap); MTY20B11_9, MTCY28_26,MTV013_8, MTCY21B4_43, MTCY493_29; etc. Also similar to O07692|MLCL383_9|MLCL383.18c HYPOTHETICAL 14.1 KDA PROTEIN from Mycobacterium leprae (129 aa), FASTA scores: opt: 293, E(): 1.3e-11, (47.85% identity in 117 aa overlap).	Q7TWL8	No	lipid metabolism							IPR004255,IPR014292	Q7TWL8	A0A1R3Y5P4				Rv3371		Rv3371			
NC_002945.3	Mycobrowser_v4	CDS	3856570	3857298	.	-	0	Mb3523c	Mb3523c		CONSERVED HYPOTHETICAL MCE ASSOCIATED ALANINE AND VALINE RICH PROTEIN	Mb3523c, -, len: 242 aa. Equivalent to Rv3493c,len: 242 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 242 aa overlap). Conserved hypothetical Mce-associated ala-, val-rich protein,showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 HYPOTHETICAL 25.9 KDA PROTEIN (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap).	Q7TWD8	No	conserved hypotheticals								Q7TWD8	A0A1R3Y4B3				Rv3493c		Rv3493c			
NC_002945.3	Mycobrowser_v4	CDS	3853290	3853613	.	+	0	Mb3518	Mb3518		CONSERVED HYPOTHETICAL PROTEIN	Mb3518, -, len: 107 aa. Equivalent to Rv3488, len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 107 aa overlap). Hypothetical protein,similar to various bacterial proteins e.g. O28730|AF1542 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (101 aa), FASTA scores: opt: 321, E(): 6.4e-15, (50.55% identity in 87 aa overlap); O50207 SQ1_IV (FRAGMENT) from Rhodococcus erythropolis (59 aa), FASTA scores: opt: 298,E(): 1.4e-13, (71.2% identity in 59 aa overlap); Q9KFB0|BH0575 BH0575 PROTEIN from Bacillus halodurans (102 aa), FASTA scores: opt: 294, E(): 4.1e-13, (43.15% identity in 95 aa overlap); etc. Also similar to M. tuberculosis P71704|Rv0047c|MTCY21D4.10c (180 aa) (37.8% identity in 82 aa overlap).	Q7TWE3	No	conserved hypotheticals							IPR005149,IPR011991	Q7TWE3	A0A1R3Y5Z2				Rv3488		Rv3488			
NC_002945.3	Mycobrowser_v4	CDS	3743796	3744449	.	+	0	Mb3410	Mb3410		CONSERVED HYPOTHETICAL PROTEIN	Mb3410, -, len: 217 aa. Equivalent to Rv3376, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Hypothetical protein,similar to various bacterial proteins (notably hydrolases) e.g. Q9RUP0|DR1344 HYDROLASE from Deinococcus radiodurans (222 aa), FASTA scores: opt: 348, E(): 1.8e-15, (36.75% identity in 215 aa overlap); Q9RXA1|DR0414 HYDROLASE (CBBY/CBBZ/GPH/YIEH FAMILY) from Deinococcus radiodurans (155 aa), FASTA scores: opt: 233, E(): 3.5e-08, (36.4% identity in 151 aa overlap); Q9X0Q9|TM1177 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (225 aa),FASTA scores: opt: 231, E(): 6.6e-08, (27.6% identity in 221 aa overlap); Q9ABI3|CC0244 HYDROLASE, HALOACID DEHALOGENASE-LIKE from Caulobacter crescentus (213 aa),FASTA scores: opt: 213, E(): 9.1e-07, (28.95% identity in 221 aa overlap); BAB38231|ECS4808 PUTATIVE PHOSPHATASE from Escherichia coli strain O157:H7 (206 aa), FASTA scores: opt: 210, E(): 1.4e-06, (26.95% identity in 193 aa overlap); etc.	Q7TWL5	No	conserved hypotheticals							IPR006439,IPR023214	Q7TWL5	A0A1R3Y426				Rv3376		Rv3376			
NC_002945.3	Mycobrowser_v4	CDS	3744541	3745992	.	-	0	Mb3411c	Mb3411c		halimadienyl diphosphate synthase	Mb3411c, -, len: 483 aa. Similar to the 5' end of Rv3377c, len: 501 aa, from Mycobacterium tuberculosis strain H37Rv, (89.9% identity in 464 aa overlap). Possible cyclase; similarity with various proteins, notably cyclases involved in steroid biosynthesis in plants and bacteria e.g. BAB52679|MLR6369 from Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA scores: opt: 533,E(): 5.6e-27, (30.45% identity in 522 aa overlap); Q9ZTN8 COPALYL DIPHOSPHATE SYNTHASE 1 from Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA scores: opt: 484, E(): 1.2e-23, (28.35% identity in 388 aa overlap); Q38710|AC22 ABIETADIENE CYCLASE from Abies grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17, (25.55% identity in 462 aa overlap); Q41771|AN1 KAURENE SYNTHASE A from Zea mays (Maize) (823 aa), FASTA scores: opt: 377,E(): 1.1e-16, (29.75% identity in 390 aa overlap); Q9AJE4 DITERPENE CYCLASE-1 from Kitasatospora griseola (Streptomyces griseolosporeus) (499 aa), FASTA scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa overlap); Q9SAU6 E-ALPHA-BISABOLENE SYNTHASE (FRAGMENT) from Abies grandis (782 aa), FASTA scores: opt: 317, E(): 7.8e-13, (25.25% identity in 479 aa overlap); etc. Note that this and the upstream ORF MTV004.36c have a significantly lower GC bias than the rest of the genome. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (caat-aac) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TWL4	No								IPR008930	Q7TWL4	A0A1R3Y420									
NC_002945.3	Mycobrowser_v4	CDS	3745997	3746887	.	-	0	Mb3412c	Mb3412c		diterpene synthase	Mb3412c, -, len: 296 aa. Equivalent to Rv3378c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Hypothetical unknown protein. Note that this ORF and the downstream ORF MTV004.35c have a significantly lower GC bias than the rest of the genome.	Q7TWL3	No	intermediary metabolism and respiration							IPR001441	Q7TWL3	A0A1R3Y403				Rv3378c		Rv3378c			
NC_002945.3	Mycobrowser_v4	CDS	3853695	3853859	.	+	0	Mb3519	Mb3519		unknown protein	Mb3519, -, len: 54 aa. Equivalent to Rv3489, len: 54 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 54 aa overlap). Hypothetical unknown protein. No similarity with other proteins.	Q7TWE2	No	conserved hypotheticals								Q7TWE2	A0A1R3Y4Z9				Rv3489		Rv3489			
NC_002945.3	Mycobrowser_v4	CDS	3774890	3776491	.	-	0	Mb3437c	Mb3437c		HYPOTHETICAL PROTEIN	Mb3437c, -, len: 533 aa. Equivalent to Rv3403c,len: 533 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 533 aa overlap). Hypothetical unknown protein, but some weak similarity to Q9KJP2 HYPOTHETICAL 54.9 KDA PROTEIN from Myxococcus xanthus (504 aa), FASTA scores: opt: 157, E(): 0.011, (24.1% identity in 548 aa overlap).	X2BNL8,P65072	No	conserved hypotheticals								X2BNL8,P65072	P65072				Rv3403c		Rv3403c			
NC_002945.3	Mycobrowser_v4	CDS	3801641	3802495	.	-	0	Mb3465c	Mb3465c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3465c, -, len: 284 aa. Equivalent to Rv3435c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Probable conserved transmembrane protein, showing some similarity with P95061|Rv0713|MTCY210.32 HYPOTHETICAL 33.9 KDA PROTEIN from Mycobacterium tuberculosis (313 aa), FASTA scores: opt: 557, E(): 1.3e-26, (35.8% identity in 282 aa overlap); and O32991|MLCB2492.12 from Mycobacterium leprae (95 aa), FASTA scores: opt: 150, E(): 0.022, (35.3% identity in 85 aa overlap). Equivalent to AAK47881 from Mycobacterium tuberculosis strain CDC1551 (312 aa) but shorter 28 aa.	Q7TWI4	No	cell wall and cell processes							IPR027948	Q7TWI4	A0A1R3Y463				Rv3435c		Rv3435c			
NC_002945.3	Mycobrowser_v4	CDS	3768466	3769512	.	+	0	Mb3432	Mb3432		possible s-adenosylmethionine-dependent methyltransferase	Mb3432, -, len: 348 aa. Equivalent to Rv3399, len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 348 aa overlap). Hypothetical protein,similar to other Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c (367 aa), FASTA scores: opt: 1188, E(): 7.7e-69, (60.05% identity in 308 aa overlap); MTCY31.21c (38.0% identity in 308 aa overlap), MTV041_5,MTCY4C12_14, MTY13D12_21, MTV043_22, MTCY210_44, MTCI5_19,MTCI5_20, MTV035_9, MTCY180_22, MTCY31_23, MTY13D12_1,MTCY180_29; etc.	X2BNB9,P59986	No	lipid metabolism								X2BNB9,P59986	P59986				Rv3399		Rv3399			
NC_002945.3	Mycobrowser_v4	CDS	3761779	3763362	.	-	0	Mb3426c	Mb3426c		CONSERVED HYPOTHETICAL PROTEIN	Mb3426c, -, len: 527 aa. Equivalent to Rv3394c,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(99.810% identity in 527 aa overlap). Hypothetical protein, with some similarity to various bacterial proteins e.g. BAB51085|MLR4427 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (545 aa), FASTA scores: opt: 267, E(): 2.8e-08, (26.5% identity in 509 aa overlap); BAB48362|MLR0866 DNA DAMAGE INDUCIBLE PROTEIN P from Rhizobium loti (Mesorhizobium loti) (438 aa), FASTA scores: opt: 245, E(): 4.6e-07, (25.5% identity in 290 aa overlap); Q9S292|SCI11.27c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 202,E(): 0.00012, (28.5% identity in 323 aa overlap); etc. Also similarity with P95102|DINP|RV3056|MTCY22D7.25c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (346 aa), FASTA scores: opt: 211, E(): 3.9e-05, (26.45% identity in 306 aa overlap). Equivalent to AAK47838 from Mycobacterium tuberculosis strain CDC1551 (492 aa) but longer 35 aa.	Q7TWK0	No	conserved hypotheticals							IPR001126,IPR017961,IPR017963	Q7TWK0	A0A1R3Y5R5				Rv3394c		Rv3394c			
NC_002945.3	Mycobrowser_v4	CDS	3773467	3774519	.	-	0	Mb3436c	Mb3436c		conserved hypothetical protein	Mb3436c, -, len: 350 aa. Equivalent to 5' end of Rv3402c, len: 412 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 350 aa overlap). Conserved hypothetical protein, probably involved in cell process, similar to various proteins generally involved in extracellular compounds (lipopolysaccharide O-antigen) biosynthesis e.g. O68392|RFBE PEROSAMINE SYNTHETASE from Brucella melitensis (367 aa), FASTA scores: opt: 420, E(): 1.2e-19, (26.15% identity in 375 aa overlap); Q9L6C1 3,4-DEHYDRATASE-LIKE PROTEIN from Streptomyces antibioticus (393 aa), FASTA scores: opt: 419, E(): 1.5e-19, (30.65% identity in 385 aa overlap); Q9RR26|OLENI DEHYDRATASE from Streptomyces antibioticus (393 aa), FASTA scores: opt: 416, E(): 2.3e-19, (30.65% identity in 385 aa overlap); O33942 ERYCIV PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (401 aa), FASTA scores: opt: 410, E(): 5.6e-19, (31.75% identity in 362 aa overlap); Q9UZI4|ASPB-LIKE1|PAB0774 ASPARTATE AMINOTRANSFERASE (ASPB-LIKE1) from Pyrococcus abyssi (366 aa), FASTA scores: opt: 402, E(): 1.7e-18, (27.05% identity in 377 aa overlap); O88001|WLBC PUTATIVE AMINO-SUGAR BIOSYNTHESIS PROTEIN from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (366 aa),FASTA scores: opt: 394, E(): 5.6e-18, (26.8% identity in 347 aa overlap); Q45378|BPLC DNA FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS from Bordetella pertussis (366 aa), FASTA scores: opt: 393, E(): 6.5e-18, (26.8% identity in 347 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product.	X2BN57,Q7TWJ6	No									X2BN57,Q7TWJ6	Q7TWJ6									
NC_002945.3	Mycobrowser_v4	CDS	3763359	3763973	.	-	0	Mb3427c	Mb3427c		CONSERVED HYPOTHETICAL PROTEIN	Mb3427c, -, len: 204 aa. Equivalent to Rv3395c,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 204 aa overlap). Conserved hypothetical protein, with some similarity with RECA PROTEINS (RECOMBINASES A) e.g. P16238|RECA_THIFE from Thiobacillus ferrooxidans (346 aa), FASTA scores: opt: 131, E(): 1.1,(31.45% identity in 140 aa overlap); Q59560|RECA_MYCSM from M. smegmatis (349 aa), FASTA scores: opt: 121, E(): 4.4, (30.25% identity in 129 aa overlap); etc. Note that shortened since first submission to avoid overlap with Rv3395A. Equivalent to AAK47839 from Mycobacterium tuberculosis strain CDC1551 (227 aa) but shorter 23 aa.	Q7TWJ9	No	conserved hypotheticals								Q7TWJ9	A0A1R3Y4R5				Rv3395c		Rv3395c			
NC_002945.3	Mycobrowser_v4	CDS	3776508	3777212	.	-	0	Mb3438c	Mb3438c		CONSERVED HYPOTHETICAL PROTEIN	Mb3438c, -, len: 234 aa. Equivalent to Rv3404c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Conserved hypothetical protein, some similarity to several METHIONYL-TRNA FORMYLTRANSFERASES e.g. BAB51418|MLL4854 from Rhizobium loti (Mesorhizobium loti) (317 aa), FASTA scores: opt: 210, E(): 1.7e-06, (27.55% identity in 178 aa overlap); P94463|FMT_BACSU from Bacillus subtilis (317 aa), FASTA scores: opt: 199 ,E(): 8.8e-06, (28.25% identity in 177 aa overlap); O51091||FMT_BORBU|BB0064 from Borrelia burgdorferi (Lyme disease spirochete) (312 aa),FASTA scores: opt: 187, E(): 5.2e-05, (30.2% identity in 192 aa overlap); etc.	X2BNC5,P65074	No	conserved hypotheticals								X2BNC5,P65074	P65074				Rv3404c		Rv3404c			
NC_002945.3	Mycobrowser_v4	CDS	3777330	3777896	.	-	0	Mb3439c	Mb3439c		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb3439c, -, len: 188 aa. Equivalent to Rv3405c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Possible transcriptional regulator, showing weak similarity to other bacterial regulatory proteins e.g. Q9KE70|BH0987 from Bacillus halodurans (203 aa), FASTA scores: opt: 168,E(): 0.0016, (34.8% identity in 92 aa overlap); Q9A5F7|CC2493 Caulobacter crescentus (204 aa), FASTA scores: opt: 160, E(): 0.0051, (32.6% identity in 89 aa overlap); Q9RDR0|SC4A7.02 from Streptomyces coelicolor (227 aa), FASTA scores: opt: 159, E(): 0.0064, (37.0% identity in 189 aa overlap); etc. Also some similarity to hypothetical Mycobacterium tuberculosis regulatory proteins e.g. O05858|Rv3208|MTCY07D11.18c, MTCI125_6,MTCY7D11_18, MTCY10G2_30; etc. Contains potential helix-turn-helix motif from aa 39-60 (+2.97 SD).	X2BNW8,P67443	No	regulatory proteins								X2BNW8,P67443	P67443				Rv3405c		Rv3405c			
NC_002945.3	Mycobrowser_v4	CDS	3777958	3778845	.	+	0	Mb3440	Mb3440		PROBABLE DIOXYGENASE	Mb3440, -, len: 295 aa. Equivalent to Rv3406, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Probable dioxygenase (EC 1.-.-.-), highly similar to Q9WWU|ATSK PUTATIVE ALPHA-KETOGLUTARATE DEPENDENT DIOXYGENASE from Pseudomonas putida (301 aa), FASTA scores: opt: 994, E(): 3.9e-57,(53.7% identity in 283 aa overlap); Q9I6U1|PA0193 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa),FASTA scores: opt: 1024, E(): 4.4e-59, (53.65% identity in 287 aa overlap); Q9HX81|TAUD|PA3935 TAURINE DIOXYGENASE from Pseudomonas aeruginosa (277 aa), FASTA scores: opt: 599, E(): 1.4e-31, (39.35% identity in 277 aa overlap); and similar to other dioxygenases e.g. AAG54718|TAUD (alias BAB33845|ECS0422) TAURINE DIOXYGENASE 2-OXOGLUTARATE-DEPENDENT from Escherichia coli strain O157:H7 (283 aa), FASTA scores: opt: 595, E(): 2.5e-31,(38.1% identity in 281 aa overlap); etc. BELONGS TO THE TFDA FAMILY OF DIOXYGENASES.	X2BPH3,P65076	No	intermediary metabolism and respiration								X2BPH3,P65076	P65076				Rv3406		Rv3406			
NC_002945.3	Mycobrowser_v4	CDS	3846116	3846805	.	-	0	Mb3511c	Mb3511c		PROBABLE INTEGRAL MEMBRANE PROTEIN	Mb3511c, -, len: 229 aa. Equivalent to Rv3481c,len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Probable integral membrane protein. No real similarity with others.	Q7TWF0	No	cell wall and cell processes							IPR021315	Q7TWF0	A0A1R3Y4E8				Rv3481c		Rv3481c			
NC_002945.3	Mycobrowser_v4	CDS	3794342	3794704	.	-	0	Mb3458c	Mb3458c		HYPOTHETICAL PROTEIN	Mb3458c, -, len: 120 aa. Equivalent to Rv3424c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). Hypothetical unknown protein.	X2BNE5	No	conserved hypotheticals								X2BNE5	P65086				Rv3424c		Rv3424c			
NC_002945.3	Mycobrowser_v4	CDS	4151494	4152069	.	-	0	Mb3796c	Mb3796c		HYPOTHETICAL LEUCINE RICH PROTEIN	Mb3796c, -, len: 191 aa. Equivalent to Rv3770c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 191 aa overlap). Hypothetical unknown leu-rich protein.	Q7TVQ4,A0A1R3Y6P7	No	conserved hypotheticals			A0A1R3Y6P7					Q7TVQ4					Rv3770c		Rv3770c			
NC_002945.3	Mycobrowser_v4	CDS	3786322	3787149	.	-	0	Mb3449c	Mb3449c		CONSERVED HYPOTHETICAL PROTEIN	Mb3449c, -, len: 275 aa. Equivalent to Rv3415c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Conserved hypothetical protein, equivalent to Q9CCV3|ML0383 HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa),FASTA scores: opt: 1278, E(): 4.2e-71, (73.5% identity in 279 aa overlap); and Q49858|B229_C1_175 HYPOTHETICAL 27.4 KDA PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1186, E(): 1.7e-65, (74.05% identity in 258 aa overlap). And C-terminus highly similar to N-terminal part of Q49726|B1620_C3_232 HYPOTHETICAL 12.9 KDA PROTEIN from Mycobacterium leprae (122 aa), FASTA scores: opt: 580, E(): 1.1e-28, (74.6% identity in 126 aa overlap). Also some similarity with P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26 RIBOFLAVIN BIOSYNTHESIS PROTEIN R (339 aa), FASTA scores: opt: 143, E(): 0.13, (28.25% identity in 184 aa overlap).	Q7TWJ3	No	conserved hypotheticals								Q7TWJ3	A0A1R3Y441				Rv3415c		Rv3415c			
NC_002945.3	Mycobrowser_v4	CDS	3800917	3801630	.	-	0	Mb3464c	Mb3464c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3464c, -, len: 237 aa. Equivalent to Rv3434c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 237 aa overlap). Possible conserved transmembrane protein, showing some similarity with Q9CGH7|YLDB HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (258 aa), FASTA scores: opt: 248, E(): 1.6e-09, (28.8% identity in 198 aa overlap); and P94983|Rv1648|MTCY06H11.13 from Mycobacterium tuberculosis (268 aa), FASTA scores: opt: 205, E(): 1.2e-06, (31.45% identity in 194 aa overlap).	Q7TWI5	No	cell wall and cell processes								Q7TWI5	A0A1R3Y482				Rv3434c		Rv3434c			
NC_002945.3	Mycobrowser_v4	CDS	3811018	3812232	.	-	0	Mb3476c	Mb3476c		HYPOTHETICAL ALANINE AND VALINE RICH PROTEIN	Mb3476c, -, len: 404 aa. Equivalent to Rv3446c,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 404 aa overlap). Hypothetical unknown ala-, val-rich protein.	Q7TWH6	No	conserved hypotheticals							IPR023840	Q7TWH6	A0A1R3Y481				Rv3446c		Rv3446c			
NC_002945.3	Mycobrowser_v4	CDS	3791687	3792322	.	-	0	Mb3455c	Mb3455c		CONSERVED HYPOTHETICAL PROTEIN	Mb3455c, -, len: 211 aa. Equivalent to Rv3421c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (GLYCOPROTEASE FAMILY PROTEIN) from Caulobacter crescentus (211 aa),FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa overlap); Q9KQK9|VC1989 from Vibrio cholerae (237 aa),FASTA scores: opt: 238, E(): 8.2e-07, (28.85% identity in 208 aa overlap); BAB51966|Mlr5530 from Rhizobium loti (Mesorhizobium loti) (225 aa), FASTA scores: opt: 237,E(): 9e-07, (35.0% identity in 220 aa overlap); etc. Some similarity to upstream Q50709|GCP_MYCTU|Rv3419c|MT3528|MTCY78.10 from M. tuberculosis (344 aa), (33.9% identity in 127 aa overlap).	X2BPJ0,P65084	No	conserved hypotheticals								X2BPJ0,P65084	P65084				Rv3421c		Rv3421c			
NC_002945.3	Mycobrowser_v4	CDS	3792319	3792825	.	-	0	Mb3456c	Mb3456c		CONSERVED HYPOTHETICAL PROTEIN	Mb3456c, -, len: 168 aa. Equivalent to Rv3422c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Conserved hypothetical protein, equivalent to Q49864|YY22_MYCLE|ML0377|U229F|B229_C2_205 HYPOTHETICAL 17.6 KDA PROTEIN from Mycobacterium leprae (161 aa), FASTA scores: opt: 752, E(): 8.3e-38, (77.4% identity in 146 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces coelicolor (148 aa), FASTA scores: opt: 377, E(): 1.2e-15,(50.85% identity in 120 aa overlap); Q9X1W7|TM1632 from Thermotoga maritima (161 aa), FASTA scores: opt: 247, E(): 6.2e-08, (39.4% identity in 137 aa overlap); Q9RRY1|DR2351 from Deinococcus radiodurans (148 aa), FASTA scores: opt: 236, E(): 2.6e-07, (38.6% identity in 127 aa overlap); etc. Contains PS00017 ATP /GTP-binding site motif A.	X2BN80,P67172	No	conserved hypotheticals								X2BN80,P67172	P67172				Rv3422c		Rv3422c			
NC_002945.3	Mycobrowser_v4	CDS	3796996	3797841	.	-	0	Mb3461c	Mb3461c		possible transposase (fragment)	Mb3461c, -, len: 281 aa. Equivalent to Rv3431c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Possible truncated transposase for IS1552, similar to, but shorter than other transposases e.g. P72303 from Rhodococcus opacus (418 aa),FASTA scores: opt: 1509, E(): 1.2e-91, (80.95% identity in 278 aa overlap); Q9AKV5 from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 1115, E(): 7.8e-66, (63.45% identity in 268 aa overlap); etc.	Q7TWI8	No	insertion seqs and phages							IPR001207	Q7TWI8	A0A1R3Y489				Rv3431c		Rv3431c			
NC_002945.3	Mycobrowser_v4	CDS	3828603	3829460	.	+	0	Mb3492	Mb3492		conserved protein	Mb3492, -, len: 285 aa. Equivalent to Rv3463, len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 285 aa overlap). Conserved hypothetical protein, similar to Q9RDA2|SCE20.23 HYPOTHETICAL 31.4 KDA PROTEIN from Streptomyces coelicolor (290 aa), FASTA scores: opt: 770, E(): 2.2e-41, (48.6% identity in 247 aa overlap); and Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (341 aa), (see BLASTP results), FASTA scores: opt: 119, E(): 2.9, (24.1% identity in 274 aa overlap).	Q7TWG8	No	conserved hypotheticals							IPR011251,IPR019922	Q7TWG8	A0A1R3Y487				Rv3463		Rv3463			
NC_002945.3	Mycobrowser_v4	CDS	3799494	3800915	.	-	0	Mb3463c	Mb3463c		conserved protein	Mb3463c, -, len: 473 aa. Equivalent to Rv3433c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 473 aa overlap). Hypothetical protein,member of YKL151c/yjeF family, equivalent to P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 HYPOTHETICAL 47.2 KDA PROTEIN from Mycobacterium leprae (473 aa), FASTA scores: opt: 2650, E(): 5e-136, (84.55% identity in 473 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa),FASTA scores: opt: 700, E(): 1.2e-30, (33.7% identity in 484 aa overlap); O86783|SC6G4.20c from Streptomyces coelicolor (485 aa), FASTA scores: opt: 563, E(): 3.2e-23,(48.45% identity in 489 aa overlap); Q9LC81 from Arthrobacter sp. Q36 (313 aa), FASTA scores: opt: 553,E(): 7.9e-23, (44.2% identity in 303 aa overlap); etc. Contains PS01049 Hypothetical YKL151c/yjeF family signature 1, PS01050 Hypothetical YKL151c/yjeF family signature 2.	Q7TWI6	No	conserved hypotheticals							IPR000631,IPR004443,IPR017953,IPR026599,IPR026600	Q7TWI6	A0A1R3Y479				Rv3433c		Rv3433c			
NC_002945.3	Mycobrowser_v4	CDS	3804613	3805089	.	+	0	Mb3467	Mb3467		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3467, -, len: 158 aa. Equivalent to Rv3437, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 158 aa overlap). Possible conserved transmenbrane protein, C-terminus similar to N-terminal part of O06345|Rv3482c|MTCY13E12.35c HYPOTHETICAL 28.5 KDA PROTEIN from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 140, E(): 0.1, (58.8% identity in 34 aa overlap); and Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from Streptomyces (347 aa), coelicolor FASTA scores: opt: 112, E(): 6.8, (50.0% identity in 32 aa overlap). Questionable ORF.	Q7TWI3	No	cell wall and cell processes							IPR018929	Q7TWI3	A0A1R3Y5V3				Rv3437		Rv3437			
NC_002945.3	Mycobrowser_v4	CDS	3805961	3807364	.	-	0	Mb3469c	Mb3469c		CONSERVED HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN	Mb3469c, -, len: 467 aa. Equivalent to Rv3439c,len: 467 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 467 aa overlap). Conserved hypothetical ala-, pro-rich protein, similar in part to N-terminal part of Q49853|B229_C1_154 HYPOTHETICAL 11.2 KDA PROTEIN from Mycobacterium leprae (103 aa), FASTA scores: opt: 265, E(): 0.0013, (51.1% identity in 90 aa overlap).	Q7TWI1	No	conserved hypotheticals								Q7TWI1	A0A1R3Y457				Rv3439c		Rv3439c			
NC_002945.3	Mycobrowser_v4	CDS	4067704	4069059	.	+	0	Mb3714	Mb3714		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3714, -, len: 451 aa. Equivalent to Rv3689, len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 451 aa overlap). Probable conserved transmembrane protein, with Proline rich N-terminus,similar to Q9KYW6|SCE33.17 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (462 aa) FASTA scores: opt: 730, E(): 2.7e-21, (38.1% identity in 412 aa overlap).	Q7TVX6	No	cell wall and cell processes								Q7TVX6	A0A1R3Y4X6				Rv3689		Rv3689			
NC_002945.3	Mycobrowser_v4	CDS	3822105	3823790	.	+	0	Mb3483	Mb3483		probable conserved integral membrane protein	Mb3483, -, len: 561 aa. Equivalent to Rv3453 and Rv3454, len: 110 aa and 422 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 107 aa overlap and 99.8% identity in 422 aa overlap). Rv3453: Possible conserved transmembrane protein, showing weak similarity with other proteins e.g. Q9F6C3 PUTATIVE ABC TRANSPORTER from Propionibacterium thoenii (424 aa), FASTA scores: opt: 104, E(): 6.8, (40.6% identity in 69 aa overlap). Rv3454: Probable conserved integral membrane protein, showing some similarity to various proteins (generally transporters) e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 145, E(): 0.13, (28.2% identity in 188 aa overlap); Q01266|YHYC_PSESN HYPOTHETICAL PROTEIN IN HYUC 3'REGION (ORF 5) (FRAGMENT) from Pseudomonas sp. strain NS671 (245 aa), FASTA scores: opt: 130, E(): 0.75, (24.65% identity in 134 aa overlap); Q9I242|PA2073 PROBABLE TRANSPORTER (MEMBRANE SUBUNIT) from Pseudomonas aeruginosa (476 aa), FASTA scores: opt: 125, E(): 2.5, (24.6% identity in 252 aa overlap); etc. Equivalent to AAK47900 from Mycobacterium tuberculosis strain CDC1551 (562 aa) but shorter 140 aa. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) results in a single product that is more similar to Rv3454.	Q7TWH0	No	cell wall and cell processes								Q7TWH0	A0A1R3Y496				Rv3453		Rv3453			
NC_002945.3	Mycobrowser_v4	CDS	4069086	4069739	.	+	0	Mb3715	Mb3715		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb3715, -, len: 217 aa. Equivalent to Rv3690, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Probable conserved membrane protein, similar to Q9KYW5|SCE33.18 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (231 aa), FASTA scores: opt: 419, E(): 1.5e-19, (36.0% identity in 211 aa overlap). Equivalent to AAK48159 from Mycobacterium tuberculosis strain CDC1551 (233 aa) but shorter 16 aa.	Q7TVX5	No	cell wall and cell processes							IPR025403	Q7TVX5	A0A1R3Y4X0				Rv3690		Rv3690			
NC_002945.3	Mycobrowser_v4	CDS	3907694	3908407	.	-	0	Mb3558c	Mb3558c		unknown protein	Mb3558c, -, len: 237 aa. Equivalent to Rv3528c,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 237 aa overlap). Hypothetical unknown protein.	Q7TWA3	No	conserved hypotheticals								Q7TWA3	A0A1R3Y636				Rv3528c		Rv3528c			
NC_002945.3	Mycobrowser_v4	CDS	3856088	3856570	.	-	0	Mb3522c	Mb3522c		CONSERVED HYPOTHETICAL MCE ASSOCIATED PROTEIN	Mb3522c, -, len: 160 aa. Equivalent to Rv3492c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213).	Q7TWD9	No	conserved hypotheticals							IPR021055	Q7TWD9	A0A1R3Y4E5				Rv3492c		Rv3492c			
NC_002945.3	Mycobrowser_v4	CDS	4018397	4018588	.	+	0	Mb3667	Mb3667		HYPOTHETICAL PROTEIN	Mb3667, -, len: 63 aa. Equivalent to Rv3643, len: 63 aa (questionable ORF), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 63 aa overlap). Identical to AAK48106 from Mycobacterium tuberculosis strain CDC1551 (33 aa) but longer 30 aa.	Q7TW18	No	conserved hypotheticals								Q7TW18	A0A1R3Y6C2				Rv3643		Rv3643			
NC_002945.3	Mycobrowser_v4	CDS	3836504	3837037	.	-	0	Mb3500c	Mb3500c		CONSERVED HYPOTHETICAL PROTEIN	Mb3500c, -, len: 177 aa. Equivalent to Rv3471c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 177 aa overlap). Conserved hypothetical protein, similar to Q59013|MJ1618 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (125 aa), FASTA scores: opt: 262, E(): 1.2e-09, (39.05% identity in 105 aa overlap); and O26452|MTH352 CONSERVED PROTEIN from Methanobacterium thermoautotrophicum (131 aa), FASTA scores: opt: 222, E(): 3.8e-07, (35.05% identity in 117 aa overlap). Equivalent to AAK47934 from Mycobacterium tuberculosis strain CDC1551 (184 aa) but shorter 7 aa.	Q7TWG0	No	conserved hypotheticals							IPR011051,IPR013096,IPR014710	Q7TWG0	A0A1R3Y4E0				Rv3471c		Rv3471c			
NC_002945.3	Mycobrowser_v4	CDS	3837058	3837564	.	+	0	Mb3501	Mb3501		conserved protein	Mb3501, -, len: 168 aa. Equivalent to Rv3472, len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins e.g. Q9ZAT9|DPSH DAUNORUBICIN BIOSYNTHESIS ENZYME from Streptomyces peucetius (194 aa), FASTA scores: opt: 181, E(): 6.8e-05, (30.7% identity in 127 aa overlap); Q53879 DAUH/E from Streptomyces sp. C5 (151 aa), FASTA scores: opt: 168, E(): 0.00038, (29.25% identity in 127 aa overlap); and Q9L4U3|AKNV from Streptomyces galilaeus (144 aa), FASTA scores: opt: 122, E(): 0.36, (31.25% identity in 129 aa overlap).	Q7TWF9	No	conserved hypotheticals								Q7TWF9	A0A1R3Y4D1				Rv3472		Rv3472			
NC_002945.3	Mycobrowser_v4	CDS	3842158	3843459	.	+	0	Mb3507	Mb3507		HYPOTHETICAL PROTEIN [FIRST PART]	Mb3507, -, len: 433 aa. Equivalent to 5' end of Rv3479, len: 1075 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 418 aa overlap). Possible transmembrane protein, with hydrophobic stretches at C-terminus. Start changed since first submission (-54 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, a 713 bp deletion splits Rv3479 into 2 parts, Mb3507 and Mb3508.	Q7TWF4	No								IPR002641,IPR016035,IPR019894,IPR024282	Q7TWF4	A0A1R3Y4B2									
NC_002945.3	Mycobrowser_v4	CDS	3843464	3844510	.	+	0	Mb3508	Mb3508		HYPOTHETICAL TRANSMEMBRANE PROTEIN [SECOND PART]	Mb3508, -, len: 348 aa. Equivalent to 3' end of Rv3479, len: 1075 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 348 aa overlap). Possible transmembrane protein, with hydrophobic stretches at C-terminus. Start changed since first submission (-54 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, a 713 bp deletion splits Rv3479 into 2 parts, Mb3507 and Mb3508.	Q7TWF3	No								IPR024282	Q7TWF3	A0A1R3Y5Y5									
NC_002945.3	Mycobrowser_v4	CDS	3844534	3845358	.	-	0	Mb3509c	Mb3509c		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb3509c, -, len: 274 aa. Equivalent to 3' end of Rv3480c, len: 497 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 274 aa overlap). Conserved hypothetical protein, similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa),FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). SEEMS TO BELONG TO THE UPF0089 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3480c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c.	Q7TWF2	No								IPR004255,IPR009721	Q7TWF2	A0A1R3Y4Z3									
NC_002945.3	Mycobrowser_v4	CDS	1146305	1146991	.	+	0	Mb1052	Mb1052		possible conserved membrane protein	Mb1052, -, len: 228 aa. Equivalent to Rv1024, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Hypothetical unknown protein, hydrophobic region from aa 83-101.	Q7U0U5,A0A1R3XX51	No	cell wall and cell processes			A0A1R3XX51				IPR007060	Q7U0U5					Rv1024		Rv1024			
NC_002945.3	Mycobrowser_v4	CDS	3845372	3846025	.	-	0	Mb3510c	Mb3510c		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb3510c, -, len: 217 aa. Equivalent to 5' end of Rv3480c, len: 497 aa, from Mycobacterium tuberculosis strain H37Rv, (98.6% identity in 216 aa overlap). Conserved hypothetical protein, similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa),FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). SEEMS TO BELONG TO THE UPF0089 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3480c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c.	Q7TWF1	No								IPR004255	Q7TWF1	A0A1R3Y493									
NC_002945.3	Mycobrowser_v4	CDS	3846947	3847729	.	-	0	Mb3512c	Mb3512c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb3512c, -, len: 260 aa. Equivalent to Rv3482c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Probable conserved membrane protein. N-terminal region shares some similarity with N-terminus of O88067|SCI35.32c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (319 aa), FASTA scores: opt: 155, E(): 0.023, (54.55% identity in 33 aa overlap); and with C-terminus of O06254|Rv3437|MTCY77.09 HYPOTHETICAL 17.9 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (alias AAK47883|MT3542.1 from strain CDC1551) (158 aa), FASTA scores: opt: 140, E(): 0.11, (58.8% identity in 34 aa overlap). Some similarity to others e.g. Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (347 aa), FASTA scores: opt: 131, E(): 0.75, (29.4% identity in 221 aa overlap). First start taken.	Q7TWE9	No	cell wall and cell processes							IPR018929	Q7TWE9	A0A1R3Y4E1				Rv3482c		Rv3482c			
NC_002945.3	Mycobrowser_v4	CDS	4047130	4047828	.	-	0	Mb3692c	Mb3692c		possible protease	Mb3692c, -, len: 232 aa. Equivalent to Rv3668c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 232 aa overlap). Possible protease (EC 3.4.-.-) (and more specifically a putative alkaline serine protease (EC 3.4.21.-), equivalent to Q9CB98|ML2295 HYPOTHETICAL PROTEIN from Mycobacterium leprae (234 aa),FASTA scores: opt: 1249, E(): 7.4e-66, (77.5% identity in 231 aa overlap). Also similar at C-terminal end with many proteases e.g. O86984 ALKALINE SERINE PROTEASE PRECURSOR from Thermomonospora fusca (368 aa), FASTA scores: opt: 190, E(): 0.00056, (28.9% identity in 173 aa overlap); Q55353|SAPII ALKALINE SERINE PROTEASE II from Streptomyces sp (382 aa), FASTA scores: opt: 160, E(): 0.032, (27.15% identity in 199 aa overlap); O54109|SC10A5.18 PUTATIVE SECRETED PROTEASE from Streptomyces coelicolor (411 aa),FASTA scores: opt: 155, E(): 0.066, (26.4% identity in 163 aa overlap); Q54392|SAL|SCI11.35C SERINE PROTEASE SAL PRECURSOR (300 aa), FASTA scores: opt: 153, E(): 0.068,(28.1% identity in 185 aa overlap); P00778|PRLA_LYSEN|ALPHA-LP ALPHA-LYTIC PROTEASE PRECURSOR (397 aa), FASTA scores: opt: 154, E(): 0.074, (26.75% identity in 172 aa overlap); etc. Also similar with Q50618|YI15_MYCTU|Rv1815|MT1863|MTCY1A11.28c HYPOTHETICAL 22.8 KDA PROTEIN from Mycobacterium tuberculosis (221 aa),FASTA scores: opt: 134, E(): 0.69, (30.95% identity in 181 aa overlap).	Q7TVZ6	No	intermediary metabolism and respiration							IPR009003	Q7TVZ6	A0A1R3Y4S1				Rv3668c		Rv3668c			
NC_002945.3	Mycobrowser_v4	CDS	3847773	3848435	.	-	0	Mb3513c	Mb3513c		possible exported protein	Mb3513c, -, len: 220 aa. Equivalent to Rv3483c,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Conserved hypothetical protein, similar to Q9CC94|ML1099 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (202 aa), FASTA scores: opt: 276, E(): 1.4e-08, (33.1% identity in 148 aa overlap). Also showing similarity with Mycobacterium tuberculosis proteins Q11065|LPRE_MYCTU|LPRE|Rv1252c|MT1291|MTCY50.30. PUTATIVE LIPOPROTEIN PRECURSOR (202 aa), FASTA scores: opt: 276,E(): 1.4e-08, (29.5% identity in 200 aa overlap); O53445|Rv1097c|MTV017.50c HYPOTHETICAL 29.9 KDA PROTEIN (293 aa), FASTA scores: opt: 161, E(): 0.047, (25.4% identity in 118 aa overlap); P71882|LPPP_MYCTU|Rv2330c|MT2392|MTCY3G12.04 PUTATIVE LIPOPROTEIN PRECURSOR (175 aa), FASTA scores: opt: 146,E(): 0.21, (28.25% identity in 184 aa overlap); and O06170|Rv2507|MTCY07A7.13 HYPOTHETICAL 28.5 KDA PROTEIN (273 aa), FASTA scores: opt: 148, E(): 0.23, (25.15% identity in 191 aa overlap).	Q7TWE8	No	cell wall and cell processes							IPR025971	Q7TWE8	A0A1R3Y4A7				Rv3483c		Rv3483c			
NC_002945.3	Mycobrowser_v4	CDS	3850245	3851189	.	-	0	Mb3515c	Mb3515c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb3515c, -, len: 314 aa. Equivalent to Rv3485c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar, but longer 41 aa, to P71824|Rv0769|MTCY369.14 PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE CY369.14 from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.0% identity in 253 aa overlap). Also similar to various dehydrogenases e.g. P25529|HDHA_ECOLI|HSDH|B1619 NAD-DEPENDENT 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE (SDR FAMILY) (EC 1.1.1.159) from Escherichia coli strain K12 (alias BAB35750|ECS2327 or AAG56608|HDHA for strain O157:H7) (255 aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.7% identity in 248 aa overlap); Q9FD15|RUBG PUTATIVE REDUCTASE (SDR FAMILY) from Streptomyces collinus (249 aa), FASTA scores: opt: 446, E(): 1.5e-18, (36.1% identity in 255 aa overlap); BAB51974|MLL5540 PUTATIVE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (253 aa), FASTA scores: opt: 442, E(): 2.5e-18, (36.25% identity in 251 aa overlap); Q08632|SDR1_PICAB SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (SDR FAMILY) from Picea abies (Norway spruce) (Picea excelsa) (271 aa), FASTA scores: opt: 441, E(): 3.1e-18, (32.3% identity in 260 aa overlap); Q9A326|CC3380 2-DEOXY-D-GLUCONATE 3-DEHYDROGENASE from Caulobacter crescentus (260 aa),FASTA scores: opt: 436, E(): 5.7e-18, (32.8% identity in 253 aa overlap); Q16698|DECR_HUMAN 2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.3.1.34) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 430, E(): 1.5e-17, (30.4% identity in 306 aa overlap); etc. Contains short-chain alcohol dehydrogenase family signature (PS00061). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (SDR).	Q7TWE6	No	intermediary metabolism and respiration							IPR002347,IPR016040,IPR020904	Q7TWE6	A0A1R3Y4D9				Rv3485c		Rv3485c			
NC_002945.3	Mycobrowser_v4	CDS	3851395	3851844	.	+	0	Mb3516	Mb3516		conserved protein	Mb3516, -, len: 149 aa. Equivalent to Rv3486, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Conserved hypothetical protein, similar to Q9RC47|YFID|BH3304 HYPOTHETICAL PROTEIN from Bacillus halodurans (129 aa),FASTA scores: opt: 186, E(): 2.1e-05, (40.0% identity in 95 aa overlap); and Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from Vibrio cholerae (148 aa), FASTA scores: opt: 128,E(): 0.15, (35.25% identity in 139 aa overlap). Some similarity to other proteins e.g. P54720|YFID_BACSU HYPOTHETICAL PROTEIN from Bacillus subtilis (134 aa),FASTA scores: opt: 165, E(): 0.00052, (31.75% identity in 126 aa overlap). Equivalent to AAK47949 from Mycobacterium tuberculosis strain CDC1551 (163 aa) but shorter 14 aa.	Q7TWE5	No	conserved hypotheticals							IPR011637	Q7TWE5	A0A1R3Y499				Rv3486		Rv3486			
NC_002945.3	Mycobrowser_v4	CDS	3951382	3951648	.	-	0	Mb3597c	Mb3597c		HYPOTHETICAL PROTEIN	Mb3597c, -, len: 88 aa. Equivalent to Rv3566A, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein.	Q7TW68	No	conserved hypotheticals								Q7TW68	A0A1R3Y4K0				Rv3566A		Rv3566A			
NC_002945.3	Mycobrowser_v4	CDS	3866710	3867663	.	-	0	Mb3532c	Mb3532c		probable short-chain type dehydrogenase/reductase. possible 17-beta-hydroxysteroid dehydrogenase.	Mb3532c, -, len: 317 aa. Equivalent to Rv3502c,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to Mycobacterium tuberculosis proteins P71853|Rv3548c|MTCY03C7.08 HYPOTHETICAL 31.1 KDA PROTEIN (304 aa), FASTA scores: opt: 739, E(): 6.2e-35, (45.15% identity in 310 aa overlap); and Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE OXIDOREDUCTASE (247 aa), FASTA scores: opt: 475,E(): 5.1e-20, (40.15% identity in 254 aa overlap). Also similar to various dehydrogenases e.g. Q9I4V1|PA1023 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (305 aa), FASTA scores: opt: 535, E(): 2.3e-23,(37.1% identity in 302 aa overlap); Q9UVH9|FOX2 FOX2 PROTEIN (SDR FAMILY) (1015 aa), FASTA scores: opt: 487,E(): 3.2e-20, (38.4% identity in 276 aa overlap); P22414|FOX2_CANTR PEROXISOMAL HYDRATASE-DEHYDROGENASE,D-3-HYDROXYACYL CoA DEHYDROGENASE (EC 1.1.1.-) (SDR FAMILY) from Candida tropicalis (Yeast) (906 aa) FASTA scores: opt: 481, E(): 6.4e-20, (38.0% identity in 250 aa overlap); P50171|DHB8_MOUSE|HSD17B8|HKE6|H2-KE6 ESTRADIOL 17 BETA-DEHYDROGENASE 8 from Mus musculus (Mouse) (260 aa) FASTA scores: opt: 459, E(): 4.3e-19, (39.75% identity in 259 aa overlap); CAC41362|BKR1 3-OXYACYL-[ACYL-CARRIER PROTEIN] REDUCTASE (EC 1.1.1.100) (FRAGMENT) from Brassica napus (Rape) (317 aa), FASTA scores: opt: 447, E(): 2.4e-18, (39.2% identity in 255 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Start uncertain.	Q7TWC9	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904	Q7TWC9	A0A1R3Y4F5				Rv3502c		Rv3502c			
NC_002945.3	Mycobrowser_v4	CDS	3979072	3979899	.	+	0	Mb3625	Mb3625		CONSERVED HYPOTHETICAL PROTEIN	Mb3625, -, len: 275 aa. Equivalent to Rv3594, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Hypothetical protein,highly similar in part with Q9ZX49|GP29 from Mycobacteriophage TM4 (547 aa), FASTA scores: opt: 526,E(): 1.3e-25, (46.25% identity in 186 aa overlap); and Q9FZS0|LYSA|GP2 from Mycobacterium phage Ms6 (384 aa) FASTA scores: opt: 147, E(): 0.064, (33.35% identity in 84 aa overlap).	Q7TW44	No	conserved hypotheticals							IPR002502	Q7TW44	A0A1R3Y4N9				Rv3594		Rv3594			
NC_002945.3	Mycobrowser_v4	CDS	3882658	3883494	.	-	0	Mb3540c	Mb3540c		conserved protein	Mb3540c, -, len: 278 aa. Equivalent to Rv3510c,len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Conserved hypothetical protein, similar to Q50662|Rv2303c|MTCY339.06 HYPOTHETICAL 34.6 KDA PROTEIN from Mycobacterium tuberculosis (307 aa), FASTA scores: opt: 416, E(): 1.2e-19, (35.7% identity in 255 aa overlap). Middle of the putative protein highly similar to N-terminal end of Q49860|B229_C2_182 HYPOTHETICAL 11.0 KDA PROTEIN from Mycobacterium leprae (95 aa), FASTA scores: opt: 304, E(): 7.9e-13, (83.65% identity in 55 aa overlap). Also some similarity with other bacterial proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 293, E(): 9.6e-12, (31.3% identity in 198 aa overlap); Q9XDF3|NONC NONC PROTEIN from Streptomyces griseus subsp. griseus (317 aa), FASTA scores: opt: 270,E(): 3.4e-10, (29.95% identity in 227 aa overlap); Q54229|NONR MACROTETROLIDE ANTIBIOTIC-RESISTANCE PROTEIN from Streptomyces griseus (347 aa), FASTA scores: opt: 270, E(): 3.6e-10, (29.95% identity in 227 aa overlap); etc.	Q7TWC1	No	conserved hypotheticals							IPR006992	Q7TWC1	A0A1R3Y4C3				Rv3510c		Rv3510c			
NC_002945.3	Mycobrowser_v4	CDS	4032670	4032876	.	-	0	Mb3680c	Mb3680c		CONSERVED HYPOTHETICAL PROTEIN	Mb3680c, -, len: 68 aa. Equivalent to Rv3656c, len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Conserved hypothetical protein, similar to Q9X918|SCH5.16c SMALL HYPOTHETICAL PROTEIN from Streptomyces coelicolor (75 aa), FASTA scores: opt: 129, E(): 0.0039, (40.0% identity in 60 aa overlap). Equivalent to AAK48120 from Mycobacterium tuberculosis strain CDC1551 (42 aa) but longer 26 aa.	Q7TW07	No	conserved hypotheticals							IPR025338	Q7TW07	A0A1R3Y4V6				Rv3656c		Rv3656c			
NC_002945.3	Mycobrowser_v4	CDS	3972183	3972977	.	-	0	Mb3618c	Mb3618c		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb3618c, -, len: 264 aa. Equivalent to Rv3587c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Probable conserved membrane protein, equivalent to Q9CBJ2|ML1918 HYPOTHETICAL MEMBRANE PROTEIN from Mycobacterium leprae (263 aa), FASTA scores: opt: 1438, E(): 2.4e-57, (77.55% identity in 267 aa overlap). Contains hydrophobic stretch in N-terminus; possible signal sequence.	Q7TW51	No	cell wall and cell processes								Q7TW51	A0A1R3Y682				Rv3587c		Rv3587c			
NC_002945.3	Mycobrowser_v4	CDS	3906820	3907269	.	+	0	Mb3557	Mb3557		HYPOTHETICAL PROTEIN	Mb3557, -, len: 149 aa. Equivalent to Rv3527, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Hypothetical unknown protein.	Q7TWA4	No	conserved hypotheticals								Q7TWA4	A0A1R3Y4G4				Rv3527		Rv3527			
NC_002945.3	Mycobrowser_v4	CDS	4067240	4067704	.	-	0	Mb3713c	Mb3713c		conserved protein	Mb3713c, -, len: 154 aa. Equivalent to Rv3688c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Hypothetical protein,similar to other bacterial hypothetical proteins e.g. Q9X934|SCH66.02c from Streptomyces coelicolor (154 aa),FASTA scores: opt: 425, E(): 3.4e-19, (46.1% identity in 154 aa overlap); Q9WZF4|TM0690 from Thermotoga maritima (149 aa), FASTA scores: opt: 326, E(): 3.4e-13, (40.4% identity in 151 aa overlap); Q9PHU3|CJ0573 from Campylobacter jejuni (147 aa), FASTA scores: opt:290 ,E(): 5.1e-11, (36.4% identity in 151 aa overlap); etc. Also some similarity to upstream O69654|Rv3686c|MTV025.034c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis.	Q7TVX7	No	conserved hypotheticals							IPR003789,IPR019004,IPR023168	Q7TVX7	A0A1R3Y4W4				Rv3688c		Rv3688c			
NC_002945.3	Mycobrowser_v4	CDS	3896647	3897486	.	+	0	Mb3546	Mb3546		CONSERVED HYPOTHETICAL PROTEIN	Mb3546, -, len: 279 aa. Equivalent to Rv3517, len: 279 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 279 aa overlap). Hypothetical protein,similar to several hypothetical mycobacterial proteins e.g. P71763|Rv1482c|MTCY277.03c from Mycobacterium tuberculosis strain H37Rv (339 aa) (alias AAK45794|MT1529 from M. tuberculosis strain CDC1551 (292 aa) but longer) FASTA scores: opt: 1040, E(): 3.7e-60, (59.0% identity in 273 aa overlap); O07396|MAV346 from M. avium (346 aa) FASTA scores: opt: 1018, E(): 1e-58, (57.2% identity in 278 aa overlap); O53421|Rv1073|MTV017.26 from Mycobacterium tuberculosis strain H37Rv (283 aa), FASTA scores: opt: 903, E(): 2.4e-51, (48.0% identity in 277 aa overlap); Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa) FASTA scores: opt: 158, E(): 0.0015, (41.8% identity in 55 aa overlap); etc.	Q7TWB5	No	conserved hypotheticals							IPR025159	Q7TWB5	A0A1R3Y4C7				Rv3517		Rv3517			
NC_002945.3	Mycobrowser_v4	CDS	3898765	3899475	.	+	0	Mb3549	Mb3549		unknown protein	Mb3549, -, len: 236 aa. Equivalent to Rv3519, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Hypothetical unknown protein. The C-terminal end is highly similar to N-terminal end of AAK47980|MT3620 HYPOTHETICAL 7.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (73 aa), FASTA scores: opt: 279, E(): 9.4e-12, (95.65% identity in 46 aa overlap). Start uncertain.	Q7TWB2	No	conserved hypotheticals							IPR010451,IPR023375	Q7TWB2	A0A1R3Y513				Rv3519		Rv3519			
NC_002945.3	Mycobrowser_v4	CDS	4123549	4124037	.	+	0	Mb3762	Mb3762		CONSERVED HYPOTHETICAL PROTEIN	Mb3762, -, len: 162 aa. Equivalent to Rv3735, len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Conserved hypothetical protein, highly similar to several bacterial hypothetical proteins e.g. Q9UX41|ORF-C09_016|SSO0651|AAK40956 from Sulfolobus solfataricus (163 aa), FASTA scores: opt: 627, E(): 1.2e-34, (55.9% identity in 161 aa overlap); O26795|MTH699 from Methanobacterium thermoautotrophicum (168 aa), FASTA scores: opt: 616, E(): 6.7e-34, (56.1% identity in 155 aa overlap); |Q9Y9J9|APE2289 from Aeropyrum pernix (191 aa),FASTA scores: opt: 591, E(): 3.4e-32, (54.65% identity in 161 aa overlap) ; etc. Contains PS00435 Peroxidases proximal heme-ligand signature.	Q7TVT6	No	conserved hypotheticals							IPR007153	Q7TVT6	A0A1R3Y531				Rv3735		Rv3735			
NC_002945.3	Mycobrowser_v4	CDS	3899540	3900583	.	-	0	Mb3550c	Mb3550c		POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE	Mb3550c, -, len: 347 aa. Equivalent to Rv3520c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Possible coenzyme F420-dependent oxidoreductase (EC 1.-.-.-), equivalent to Q9CCV8|ML0348 POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE from Mycobacterium leprae (350 aa), FASTA scores: opt: 2029, E(): 9.1e-120, (86.85% identity in 342 aa overlap). Similar to many coenzyme F420-dependent enzymes (and other proteins) e.g. Q9AD98|SCI52.11c PUTATIVE ATP/GTP-BINDING PROTEIN from Streptomyces coelicolor (351 aa), FASTA scores: opt: 859, E(): 1.6e-46,(41.9% identity in 346 aa overlap); Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (341 aa), FASTA scores: opt: 800, E(): 7.9e-43, (38.95% identity in 339 aa overlap); Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa), FASTA scores: opt: 354, E(): 6.7e-15, (34.2% identity in 336 aa overlap); Q49598|MER COENZYME F420-DEPENDENT N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Methanopyrus kandleri (349 aa), FASTA scores: opt: 283,E(): 1.9e-10, (26.75% identity in 329 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Methanococcus jannaschii (331 aa), FASTA scores: opt: 227,E(): 5.8e-07, (26.35% identity in 334 aa overlap); O27784|MTH1752 COENZYME F420-DEPENDENT N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE from Methanobacterium thermoautotrophicum (321 aa), FASTA scores: opt: 207, E(): 1e-05, (27.4% identity in 336 aa overlap); etc. Also similar to Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 313, E(): 2.5e-12, (28.0% identity in 311 aa overlap).	Q7TWB1	No	intermediary metabolism and respiration							IPR011251,IPR019951	Q7TWB1	A0A1R3Y4D5				Rv3520c		Rv3520c			
NC_002945.3	Mycobrowser_v4	CDS	3900736	3901647	.	+	0	Mb3551	Mb3551		CONSERVED HYPOTHETICAL PROTEIN	Mb3551, -, len: 303 aa. Equivalent to Rv3521, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Conserved hypothetical protein, similar to (although longer than) other conserved hypothetical proteins e.g. O29296|AF0966 from Archaeoglobus fulgidus (176 aa), FASTA scores: opt: 286,E(): 5.4e-11, (31.15% identity in 170 aa overlap); O30036|AF0203 from Archaeoglobus fulgidus (149 aa) FASTA scores: opt: 259, E(): 2.3e-09, (33.8% identity in 142 aa overlap); O29297|AF0965 from Archaeoglobus fulgidus (154 aa), FASTA scores: opt: 241, E(): 3.2e-08, (31.4% identity in 137 aa overlap); Q9Y995|APE2390 from Aeropyrum pernix (157 aa), FASTA scores: opt: 204, E(): 6.8e-06, (27.45% identity in 153 aa overlap); BAB60424|TVG1322512 from Thermoplasma volcanium (164 aa), FASTA scores: opt: 183,E(): 0.00015, (29.75% identity in 148 aa overlap); etc. Equivalent to AAK47982 from Mycobacterium tuberculosis strain CDC1551 (334 aa) but shorter 31 aa.	Q7TWB0	No	conserved hypotheticals							IPR002878,IPR012340	Q7TWB0	A0A1R3Y4J1				Rv3521		Rv3521			
NC_002945.3	Mycobrowser_v4	CDS	51812	52681	.	-	0	Mb0049c	Mb0049c		POSSIBLE MEMBRANE PROTEIN	Mb0049c, -, len: 289 aa. Equivalent to Rv0048c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 289 aa overlap). Possible membrane protein.	Q7U2Y7,A0A1R3XVA5	No	cell wall and cell processes			A0A1R3XVA5				IPR012551	Q7U2Y7					Rv0048c		Rv0048c			
NC_002945.3	Mycobrowser_v4	CDS	3903970	3905001	.	+	0	Mb3554	Mb3554		PROBABLE CONSERVED MEMBRANE PROTEIN	Mb3554, -, len: 343 aa. Equivalent to Rv3524, len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 343 aa overlap). Probable conserved membrane protein, showing some similarity to C-terminal part of putative Mycobacterium tuberculosis proteins O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.08 serine-threonine protein kinase PknD (EC 2.7.1.-) (664 aa) FASTA scores: opt: 727, E(): 8.3e-36, (45.3% identity in 298 aa overlap); O53893|Rv0980c|MTV044.08c PGRS-FAMILY PROTEIN (457 aa), FASTA scores: opt: 208, E(): 4.4e-05,(33.75% identity in 166 aa overlap); and O53891|Rv0978c|MTV044.06c PGRS-FAMILY PROTEIN (331 aa) FASTA scores: opt: 153, E(): 0.062, (30.75% identity in 117 aa overlap). Contains PS00237 G-protein coupled receptors signature.	Q7TWA7	No	cell wall and cell processes							IPR001258,IPR011042,IPR013017	Q7TWA7	A0A1R3Y4G1				Rv3524		Rv3524			
NC_002945.3	Mycobrowser_v4	CDS	3905015	3905539	.	-	0	Mb3555c	Mb3555c		POSSIBLE SIDEROPHORE-BINDING PROTEIN	Mb3555c, -, len: 174 aa. Equivalent to Rv3525c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Possible siderophore-binding protein, similar to ferripyochelin binding proteins (and related) e.g. Q9RSN5|DR2089 FERRIPYOCHELIN-BINDING PROTEIN from Deinococcus radiodurans (240 aa), FASTA scores: opt: 472, E(): 3.3e-21, (46.9% identity in 162 aa overlap); O59257|PH1591 LONG HYPOTHETICAL FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus horikoshii (173 aa), FASTA scores: opt: 431,E(): 6.7e-19, (40.0% identity in 170 aa overlap); Q9V158|FBP|PAB0393 FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus abyssi (173 aa), FASTA scores: opt: 429, E(): 8.9e-19, (39.4% identity in 170 aa overlap); BAB47820|MLR0180 FERRIPYOCHELIN BINDING PROTEIN-LIKE from Rhizobium loti (Mesorhizobium loti) (175 aa), FASTA scores: opt: 415, E(): 6.1e-18, (42.55% identity in 141 aa overlap); etc.	Q7TWA6	No	intermediary metabolism and respiration							IPR001451,IPR011004	Q7TWA6	A0A1R3Y4H9				Rv3525c		Rv3525c			
NC_002945.3	Mycobrowser_v4	CDS	3910253	3911035	.	-	0	Mb3560c	Mb3560c		POSSIBLE OXIDOREDUCTASE	Mb3560c, -, len: 260 aa. Equivalent to Rv3530c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. BAB53258|Q987E5|MLL7083 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 405, E(): 5.3e-18, (33.45% identity in 263 aa overlap); Q9VNF3|CG12171 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (257 aa), FASTA scores: opt: 404, E(): 6.1e-18, (32.8% identity in 256 aa overlap); Q9A3X5|CC3076 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus (254 aa), FASTA scores: opt: 400, E(): 1.1e-17,(31.0% identity in 255 aa overlap); BAB50080|MLR3115 DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (259 aa), FASTA scores: opt: 393, E(): 3e-17, (31.9% identity in 254 aa overlap); Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE from Streptomyces antibioticus (273 aa), FASTA scores: opt: 388, E(): 6.3e-17, (31.6% identity in 250 aa overlap); etc.	Q7TWA1	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040	Q7TWA1	A0A1R3Y4E4				Rv3530c		Rv3530c			
NC_002945.3	Mycobrowser_v4	CDS	3920277	3921137	.	+	0	Mb3568	Mb3568		probable dehydrogenase. possible 2-enoyl acyl-coa hydratase.	Mb3568, -, len: 286 aa. Equivalent to Rv3538, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 842, E(): 3.6e-44, (48.4% identity in 285 aa overlap); and similar to C-terminal part of other (principally ESTRADIOL 17 BETA-DEHYDROGENASES/17-BETA-HYDROXYSTEROID DEHYDROGENASES) e.g. P70540 PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE II (SDR FAMILY) from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 622, E(): 1.9e-30, (37.45% identity in 283 aa overlap); or P70523|MPF-2 MULTIFUNCTIONAL PROTEIN 2 (SDR FAMILY) (beta-oxidation protein displaying 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity) from Rattus norvegicus (Rat) (734 aa), FASTA scores: opt: 616, E(): 4.3e-30, (37.1% identity in 283 aa overlap); P51659|DHB4_HUMAN|HSD17B4|EDH17B4 ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) from Homo sapiens (Human) (736 aa), FASTA scores: opt: 614, E(): 5.7e-30, (35.9% identity in 284 aa overlap); P97852|DHB4_RAT|HSD17B4|EDH17B4 ESTRADIOL 17 BETA-DEHYDROGENASE from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 613, E(): 6.6e-30, (37.1% identity in 283 aa overlap); Q9DBM3|HSD17B4 ESTRADIOL 17 BETA-DEHYDROGENASE from Mus musculus (Mouse) (735 aa) FASTA scores: opt: 611, E(): 8.7e-30, (36.5% identity in 285 aa overlap); etc. Also similar to Q11198|Rv3389c|MTV004.47c HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 609, E(): 5.3e-30, (39.65% identity in 285 aa overlap). Note that previously known as ufaA2.	Q7TW94	No	intermediary metabolism and respiration							IPR002539	Q7TW94	A0A1R3Y637				Rv3538		Rv3538			
NC_002945.3	Mycobrowser_v4	CDS	3923874	3924263	.	-	0	Mb3571c	Mb3571c		conserved protein	Mb3571c, -, len: 129 aa. Equivalent to Rv3541c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Hypothetical protein,showing some similarity to Q9CBJ7|ML1909 HYPOTHETICAL PROTEIN from Mycobacterium leprae (142 aa) FASTA scores: opt: 110, E(): 1.2, (27.95% identity in 118 aa overlap); and other (see also BLASTP results) e.g. Q9L0M3|SCD82.08 HYPOTHETICAL 15.2 KDA PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 127, E(): 0.086, (27.65% identity in 123 aa overlap). Contains PS00075 Dihydrofolate reductase signature.	Q7TW91	No	conserved hypotheticals								Q7TW91	A0A1R3Y4K7				Rv3541c		Rv3541c			
NC_002945.3	Mycobrowser_v4	CDS	3924260	3925195	.	-	0	Mb3572c	Mb3572c		CONSERVED HYPOTHETICAL PROTEIN	Mb3572c, -, len: 311 aa. Equivalent to Rv3542c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Hypothetical protein,showing some similarity to other e.g. Q58947|MJ1552 from Methanococcus jannaschii (141 aa) FASTA scores: opt: 177,E(): 0.00065, (46.65% identity in 60 aa overlap); BAB59276|TVG0142586 from Thermoplasma volcanium (135 aa),FASTA scores: opt: 175, E(): 0.00083, (35.65% identity in 87 aa overlap); Q9HI85|TA1457 from Thermoplasma acidophilum (135 aa), FASTA scores: opt: 162, E(): 0.0052,(31.8% identity in 107 aa overlap); etc.	Q7TW90	No	conserved hypotheticals							IPR002878,IPR012340	Q7TW90	A0A1R3Y4J6				Rv3542c		Rv3542c			
NC_002945.3	Mycobrowser_v4	CDS	3930597	3931511	.	-	0	Mb3578c	Mb3578c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb3578c, -, len: 304 aa. Equivalent to Rv3548c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases/reductases (generally belonging to the SDR FAMILY) e.g. Q9I4V1|PA1023 from Pseudomonas aeruginosa (305 aa), FASTA scores: opt: 446, E(): 1.7e-17,(43.75% identity in 256 aa overlap); Q9A6K0|CC2093 from Caulobacter crescentus (301 aa) FASTA scores: opt: 437,E(): 5.3e-17, (42.8% identity in 257 aa overlap); Q9HYH8|PA3427 from Pseudomonas aeruginosa (303 aa), FASTA scores: opt: 399, E(): 6.5e-15, (45.5% identity in 257 aa overlap); Q9VXJ0|CG3415 from Drosophila melanogaster (Fruit fly) (598 aa), FASTA scores: opt: 402, E(): 7.5e-15, (40.7% identity in 285 aa overlap); etc. Also highly similar to O53547|Rv3502c|MTV023.09c PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from (317 aa) FASTA scores: opt: 739, E(): 1.6e-33, (45.15% identity in 310 aa overlap); and other proteins from Mycobacterium tuberculosis. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TW85	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904	Q7TW85	A0A1R3Y654				Rv3548c		Rv3548c			
NC_002945.3	Mycobrowser_v4	CDS	3931534	3932313	.	-	0	Mb3579c	Mb3579c		PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	Mb3579c, -, len: 259 aa. Equivalent to Rv3549c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases (generally belong to the SDR FAMILY) e.g. Q9UKU3 from Homo sapiens (Human) (270 aa),FASTA scores: opt: 451, E(): 4.8e-21, (38.05% identity in 247 aa overlap); Q9S274|SCI28.09c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 439, E(): 2.4e-20,(36.8% identity in 231 aa overlap); Q9PFI6|XF0671 from Xylella fastidiosa (247 aa), FASTA scores: opt: 437, E(): 3.4e-20, (37.7% identity in 252 aa overlap); etc. Also highly similar to O33308|FABG5|Rv2766c|MTV002.31c ALCOHOL DEHYDROGENASE (SDR FAMILY) from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 504, E(): 2.3e-24, (38.5% identity in 244 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TW84	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040,IPR020904	Q7TW84	A0A1R3Y543				Rv3549c		Rv3549c			
NC_002945.3	Mycobrowser_v4	CDS	3933111	3933989	.	+	0	Mb3581	Mb3581		POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT)	Mb3581, -, len: 292 aa. Equivalent to Rv3551, len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 292 aa overlap). Possible CoA-transferase, alpha subunit (EC 2.8.3.-), similar in part to other CoA-transferases e.g. Q59111|GCTA_ACIFE|GCTA GLUTACONATE COA-TRANSFERASE SUBUNIT A (EC 2.8.3.12) (GCT LARGE SUBUNIT) from Acidaminococcus fermentans (319 aa) FASTA scores: opt: 247, E(): 6.3e-09, (27.35% identity in 307 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA scores: opt: 222, E(): 2.3e-07, (27.55% identity in 243 aa overlap); BAB50895|MLL4183 from Rhizobium loti (Mesorhizobium loti) (285 aa), FASTA scores: opt: 206, E(): 2.8e-06, (27.4% identity in 281 aa overlap); etc. Also some similarity with O06167|SCOA_MYCTU|RVv504c|MT2579|MTCY07A7.10c PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE SUBUNIT A from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 210, E(): 1.4e-06, (25.5% identity in 247 aa overlap). BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT A FAMILY. Note that this putative protein may combine with the putative protein encoded by the downstream ORF Rv3552 to form a CoA-transferase that comprises two subunits.	Q7TW82	No	intermediary metabolism and respiration							IPR004165	Q7TW82	A0A1R3Y4L3				Rv3551		Rv3551			
NC_002945.3	Mycobrowser_v4	CDS	3933986	3934738	.	+	0	Mb3582	Mb3582		POSSIBLE COA-TRANSFERASE (BETA SUBUNIT)	Mb3582, -, len: 250 aa. Equivalent to Rv3552, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Possible CoA-transferase, beta subunit (EC 2.8.3.-), similar in part to other CoA-transferases e.g. Q9I6R1|PA0227 from Pseudomonas aeruginosa (260 aa), FASTA scores: opt: 233,E(): 8.6e-08, (24.8% identity in 238 aa overlap); BAB50894|MLL4181 from Rhizobium loti (Mesorhizobium loti) (264 aa), FASTA scores: opt: 210, E(): 2.6e-06, (24.15% identity in 203 aa overlap); and AAK41345|Q97Z51|GCTB from Sulfolobus solfataricus (245 aa), FASTA scores: opt: 122,E(): 1.1, (25.5% identity in 243 aa overlap). POSSIBLY BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT B FAMILY. Note that this putative protein may combine with the putative protein encoded by the upstream ORF Rv3551 to form a CoA-transferase that comprises two subunits.	X2BNK8,P63653	No	intermediary metabolism and respiration								X2BNK8,P63653	P63653				Rv3552		Rv3552			
NC_002945.3	Mycobrowser_v4	CDS	3934836	3935903	.	+	0	Mb3583	Mb3583		POSSIBLE OXIDOREDUCTASE	Mb3583, -, len: 355 aa. Equivalent to Rv3553, len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 355 aa overlap). Possible oxidoreductase (EC 1.-.-.-), highly similar (except in C-terminus) to Q9A327|CC3379 HYPOTHETICAL PROTEIN from Caulobacter crescentus (321 aa), FASTA scores: opt: 639,E(): 4.6e-29, (46.35% identity in 248 aa overlap); and Q9WZQ7|TM0800 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (314 aa), FASTA scores: opt: 622, E(): 4.1e-28, (37.95% identity in 340 aa overlap). Also similar to two TRANS-2-ENOYL-ACP REDUCTASES; Q99YD4|FABK|SPY1751 from Streptococcus pyogenes (323 aa), FASTA scores: opt: 604, E(): 4.4e-27, (33.25% identity in 346 aa overlap); and Q9FBC5|FABK from Streptococcus pneumoniae (324 aa),FASTA scores: opt: 553, E(): 3.3e-24, (32.1% identity in 346 aa overlap); and similar with several 2-NITROPROPANE DIOXYGENASES, e.g. Q9F7P8 from uncultured proteobacterium EBAC31A08 (322 aa), FASTA scores: opt: 505, E(): 1.7e-21,(33.6% identity in 348 aa overlap); Q9FMG0 (alias AAK44141) from Arabidopsis thaliana (Mouse-ear cress) (333 aa), FASTA scores: opt: 489, E(): 1.4e-20, (33.15% identity in 341 aa overlap); O28109|AF2173 (NCD2) from Archaeoglobus fulgidus (274 aa), FASTA scores: opt: 456,E(): 8.9e-19, (36.3% identity in 237 aa overlap); etc.	Q7TW81	No	intermediary metabolism and respiration							IPR004136,IPR013785	Q7TW81	A0A1R3Y4H7				Rv3553		Rv3553			
NC_002945.3	Mycobrowser_v4	CDS	3938045	3938914	.	-	0	Mb3585c	Mb3585c		conserved protein	Mb3585c, -, len: 289 aa. Equivalent to Rv3555c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 289 aa overlap). Hypothetical protein,highly similar to others from Mycobacterium tuberculosis e.g. O53562|AL022022|Rv3517|MTV023.24 (279 aa), FASTA scores: opt: 874, E(): 8.3e-48, (49.45% identity in 275 aa overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FASTA scores: opt: 755, E(): 3e-40, (45.75% identity in 260 aa overlap); O69681|Rv3714c|MTV025.062c (296 aa), FASTA scores: opt: 733, E(): 6.4e-39, (44.1% identity in 281 aa overlap); etc. Also highly similar to other mycobacterial hypothetical proteins e.g. O07396|MAV346 from M. avium (346 aa), FASTA scores: opt: 714, E(): 1.1e-37, (44.6% identity in 260 aa overlap); and Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa), FASTA scores: opt: 130,E(): 0.17, (35.1% identity in 57 aa overlap) (only partial homology with this protein). Shows some similarity to P52392|NHSR_STRAS PUTATIVE NOSIHEPTIDE RESISTANCE REGULATORY PROTEIN (ORF699) from Streptomyces actuosus (233 aa), FASTA scores: opt: 120, E(): 1.9, (25.25% identity in 194 aa overlap).	Q7TW79	No	conserved hypotheticals							IPR007569,IPR011335,IPR025159	Q7TW79	A0A1R3Y4K1				Rv3555c		Rv3555c			
NC_002945.3	Mycobrowser_v4	CDS	3940244	3940846	.	-	0	Mb3587c	Mb3587c		transcriptional regulatory protein (probably tetr-family)	Mb3587c, -, len: 200 aa. Equivalent to Rv3557c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Probable transcriptional regulator, tetR family, similar to other e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa) FASTA scores: opt: 326, E(): 2.3e-14, (31.2% identity in 189 aa overlap); Q9HZW2|PA2885 from Pseudomonas aeruginosa (198 aa), FASTA scores: opt: 308, E(): 3.5e-13, (31.55% identity in 187 aa overlap); Q9RFR4 from Pseudomonas fluorescens (207 aa), FASTA scores: opt: 291, E(): 4.7e-12, (29.75% identity in 195 aa overlap); Q9K8P5|BH2958 from Bacillus halodurans (215 aa), FASTA scores: opt: 271, E(): 9.9e-11, (23.95% identity in 192 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O53641|Rv0158|MTV032.01 (214 aa), FASTA scores: opt: 232, E(): 3.5e-08, (25.5% identity in 192 aa overlap); and O06169|Rv2506|MTCY07A7.12 (215 aa), FASTA scores: opt: 215, E(): 4.5e-07, (35.15% identity in 148 aa overlap); etc. SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TW77	No	regulatory proteins							IPR001647,IPR009057,IPR011075,IPR015893	Q7TW77	A0A1R3Y4J0				Rv3557c		Rv3557c			
NC_002945.3	Mycobrowser_v4	CDS	3942862	3943650	.	-	0	Mb3589c	Mb3589c		probable oxidoreductase	Mb3589c, -, len: 262 aa. Equivalent to Rv3559c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 262 aa overlap). Putative oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases e.g. Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE (SDR FAMILY) from Streptomyces antibioticus (273 aa), FASTA scores: opt: 510, E(): 2.8e-24, (40.15% identity in 249 aa overlap);Q9L2C9|SC7A8.29 PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 500,E(): 1.1e-23, (41.4% identity in 239 aa overlap); Q9HQ41|FABG|VNG1341G 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE from Halobacterium sp. strain NRC-1 (255 aa) FASTA scores: opt: 500, E(): 1.1e-23, (40.0% identity in 250 aa overlap); etc. Also similar to oxidoreductases from Mycobacterium tuberculosis eg Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE OXIDOREDUCTASE (247 aa), FASTA scores: opt: 497,E(): 1.6e-23, (39.2% identity in 245 aa overlap).	Q7TW75	No	intermediary metabolism and respiration							IPR002198,IPR002347,IPR016040	Q7TW75	A0A1R3Y547				Rv3559c		Rv3559c			
NC_002945.3	Mycobrowser_v4	CDS	4032347	4032646	.	-	0	Mb3679c	Mb3679c		CONSERVED HYPOTHETICAL PROTEIN	Mb3679c, -, len: 99 aa. Equivalent to Rv3655c, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Hypothetical protein,with similarity to Q9X917|SCH5.15c HYPOTHETICAL 15.2 KDA PROTEIN from Streptomyces coelicolor (150 aa) FASTA scores: opt: 211, E(): 7.7e-07, (39.65% identity in 111 aa overlap). Equivalent to AAK48119 from Mycobacterium tuberculosis strain CDC1551 (99 aa) but longer 26 aa at the C-terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa).	Q7TW08	No	conserved hypotheticals								Q7TW08	A0A1R3Y4U2				Rv3655c		Rv3655c			
NC_002945.3	Mycobrowser_v4	CDS	3956726	3957256	.	+	0	Mb3603	Mb3603		unknown protein	Mb3603, -, len: 176 aa. Equivalent to Rv3572, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Hypothetical unknown protein.	Q7TW62	No	conserved hypotheticals								Q7TW62	A0A1R3Y4J7				Rv3572		Rv3572			
NC_002945.3	Mycobrowser_v4	CDS	3986193	3986276	.	-	0	Mb3629A	Mb3629A		Hypothetical short protein	Mb3629A, len: 27 aa. Equivalent to Rv3599c len: 27 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 27 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Hypothetical unknown protein.	X2BPD6	No	unknown								X2BPD6	A0A1R3Y4M2				Rv3599c		Rv3599c			
NC_002945.3	Mycobrowser_v4	CDS	3971106	3972182	.	+	0	Mb3617	Mb3617		CONSERVED HYPOTHETICAL PROTEIN	Mb3617, -, len: 358 aa. Equivalent to Rv3586, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 358 aa overlap). Conserved hypothetical protein, highly similar to Q9X8L6|SCE94.03 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (374 aa),FASTA scores: opt: 1338, E(): 5e-75, (59.95% identity in 347 aa overlap); P37573|YACK_BACSU HYPOTHETICAL 40.7 KDA PROTEIN from Bacillus subtilis (360 aa), FASTA scores: opt: 875, E(): 1.4e-46, (42.15% identity in 344 aa overlap); Q9KGG0|BH0105 HYPOTHETICAL PROTEIN from Bacillus halodurans (357 aa), FASTA scores: opt: 844, E(): 1.1e-44,(40.3% identity in 350 aa overlap); Q9WY43|TM0200 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (357 aa), FASTA scores: opt: 735, E(): 5.7e-38, (39.4% identity in 353 aa overlap). Also some similarity with other proteins. Contains probable coiled-coil from 144 to 179.	X2BNN8,Q7TW52	No	conserved hypotheticals								X2BNN8,Q7TW52	Q7TW52				Rv3586		Rv3586			
NC_002945.3	Mycobrowser_v4	CDS	3960304	3961383	.	-	0	Mb3606c	Mb3606c		TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LACI-FAMILY)	Mb3606c, -, len: 359 aa. Equivalent to Rv3575c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable transcriptional regulator belonging to lacI family,similar to others e.g. BAB53947|MLL8376 from Rhizobium loti (Mesorhizobium loti) (358 aa), FASTA scores: opt: 707, E(): 2.6e-35, (35.5% identity in 355 aa overlap); Q9RRI9|DR2501 from Deinococcus radiodurans (359 aa) FASTA scores: opt: 544, E(): 1.6e-25, (40.35% identity in 347 aa overlap); Q9RL31|SCF51A.34 from Streptomyces coelicolor (347 aa), FASTA scores: opt: 307, E(): 2.9e-11, (30.0% identity in 330 aa overlap); O87590|CELR_THEFU from Thermomonospora fusca (340 aa), FASTA scores: opt: 280,E(): 1.2e-09, (32.3% identity in 353 aa overlap); P21867|RAFR_ECOLI from Escherichia coli (335 aa) FASTA scores: opt: 241, E(): 2.6e-07, (27.15% identity in 269 aa overlap); etc. Equivalent to AAK48039 from Mycobacterium tuberculosis strain CDC1551 (404 aa) but shorter 45 aa. Contains possible helix-turn-helix motif, at aa 9-30 (+5.86 SD). COULD BELONG TO THE LACI FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TW59	No	regulatory proteins							IPR000843,IPR010982,IPR028082	Q7TW59	A0A1R3Y4I2				Rv3575c		Rv3575c			
NC_002945.3	Mycobrowser_v4	CDS	3962477	3963343	.	+	0	Mb3608	Mb3608		CONSERVED HYPOTHETICAL PROTEIN	Mb3608, -, len: 288 aa. Equivalent to Rv3577, len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap), (other start sites possible upstream; equivalent to AAK48041 from Mycobacterium tuberculosis strain CDC1551 (379 aa) but shorter 91 aa). Hypothetical protein, showing some similarity to Q9RI88|SCJ11.16c HYPOTHETICAL 37.9 KDA PROTEIN from Streptomyces coelicolor (349 aa) FASTA scores: opt: 285, E(): 1.5e-10, (27.45% identity in 266 aa overlap).	Q7TW57	No	conserved hypotheticals							IPR001279	Q7TW57	A0A1R3Y662				Rv3577		Rv3577			
NC_002945.3	Mycobrowser_v4	CDS	3964401	3965609	.	-	0	Mb3610c	Mb3610c		possible trna/rrna methyltransferase	Mb3610c, -, len: 402 aa. Equivalent to Rv3579c,len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 316 aa overlap). Putative tRNA/rRNA methyltransferase (EC 2.1.1.-), equivalent, but longer 31 aa, to Q9CCW4|ML0324 PUTATIVE METHYLTRANSFERASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1517,E(): 3.4e-79, (83.75% identity in 277 aa overlap). Also highly similar to Q9L0Q5|SCD8A.09 from Streptomyces coelicolor (314 aa), FASTA scores: opt: 937, E(): 3.4e-46,(56.75% identity in 319 aa overlap); and similar to others e.g. Q06753|YACO_BACSU from Bacillus subtilis (249 aa),FASTA scores: opt: 616, E(): 4.9e-28, (41.05% identity in 246 aa overlap); Q9KGF2|BH0113 from Bacillus halodurans (249 aa), FASTA scores: opt: 596, E(): 6.7e-27, (38.5% identity in 244 aa overlap); P74328|Y955_SYNY3|SLR0955 from Synechocystis sp. strain PCC 6803 (384 aa), FASTA scores: opt: 585, E(): 4e-26, (35.85% identity in 304 aa overlap); P39290|YJFH_ECOLI|B4180 from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 521, E(): 1.2e-22,(38.1% identity in 244 aa overlap); etc. Equivalent to AAK48043 from Mycobacterium tuberculosis strain CDC1551 (253 aa) but longer 69 aa. POSSIBLY BELONGS TO THE RNA METHYLTRANSFERASE TRMH FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium strain H37Rv (402 aa versus 322 aa).	X2BPC3,Q7TW55	No	intermediary metabolism and respiration								X2BPC3,Q7TW55	Q7TW55				Rv3579c		Rv3579c			
NC_002945.3	Mycobrowser_v4	CDS	4032886	4033461	.	-	0	Mb3681c	Mb3681c		POSSIBLE CONSERVED ALANINE RICH MEMBRANE PROTEIN	Mb3681c, -, len: 191 aa. Equivalent to Rv3657c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 191 aa overlap). Possible conserved membrane protein, rich in ala residues, similar to Q9X919|SCH5.17c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 324,E(): 4.7e-12, (40.9% identity in 154 aa overlap).	Q7TW06	No	cell wall and cell processes							IPR018076	Q7TW06	A0A1R3Y4W1				Rv3657c		Rv3657c			
NC_002945.3	Mycobrowser_v4	CDS	3996191	3996733	.	+	0	Mb3641	Mb3641		HYPOTHETICAL ARGININE AND PROLINE RICH PROTEIN	Mb3641, -, len: 180 aa. Equivalent to Rv3611, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 173 aa overlap). Hypothetical unknown arg-, pro-rich protein. Possible ORF containing several direct repeats. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 111 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217 aa).	Q7TW38	No	conserved hypotheticals								Q7TW38	A0A1R3Y4T1				Rv3611		Rv3611			
NC_002945.3	Mycobrowser_v4	CDS	3968272	3968760	.	-	0	Mb3614c	Mb3614c		possible transcription factor	Mb3614c, -, len: 162 aa. Equivalent to Rv3583c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Possible transcriptional factor, identical to Q9CCW7|ML0320 PUTATIVE TRANSCRIPTION FACTOR from Mycobacterium leprae (165 aa), FASTA scores: opt: 1004, E(): 6.1e-56, (97.55% identity in 162 aa overlap); and Q9ZBM8|MLCB1450.01c PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (94 aa), FASTA scores: opt: 600, E(): 6e-31,(97.85% identity in 94 aa overlap). Also highly similar to others e.g. Q9L0Q9|SCD8A.05 from Streptomyces coelicolor (160 aa), FASTA scores: opt: 878, E(): 4.3e-48, (85.0% identity in 160 aa overlap); Q9K600|BH3935 from Bacillus halodurans (153 aa) FASTA scores: opt: 383, E(): 3.1e-17,(36.4% identity in 151 aa overlap); Q9KD36|BH1383 from Bacillus halodurans (164 aa) FASTA scores: opt: 305, E(): 2.4e-12, (33.55% identity in 164 aa overlap); etc.	Q7TW53	No	regulatory proteins							IPR003711	Q7TW53	A0A1R3Y4L1				Rv3583c		Rv3583c			
NC_002945.3	Mycobrowser_v4	CDS	3996648	3996977	.	-	0	Mb3642c	Mb3642c		CONSERVED HYPOTHETICAL PROTEIN	Mb3642c, -, len: 109 aa. Equivalent to Rv3612c,len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Conserved hypothetical protein. Residues 58 to 81 highly similar to N-terminal part of AAK46718|MT2424 HYPOTHETICAL 3.9 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (36 aa), FASTA scores: opt: 108, E(): 0.38, (69.25% identity in 26 aa overlap).	Q7TW37	No	conserved hypotheticals								Q7TW37	A0A1R3Y4N3				Rv3612c		Rv3612c			
NC_002945.3	Mycobrowser_v4	CDS	3976484	3977257	.	-	0	Mb3622c	Mb3622c		possible hydrolase	Mb3622c, -, len: 257 aa. Equivalent to Rv3591c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 257 aa overlap). Possible hydrolase (EC 3.-.-.-), equivalent to Q9CBI9|ML1921 HYPOTHETICAL PROTEIN from Mycobacterium leprae (256 aa) FASTA scores: opt: 1421, E(): 5.6e-83, (78.5% identity in 251 aa overlap). Also similar to others e.g. Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from Streptomyces coelicolor (352 aa),FASTA scores: opt: 193, E(): 5.2e-05, (33.35% identity in 270 aa overlap); O33745|STTC THIOESTERASE (EC 3.1.2.-) from Streptomyces sp (308 aa) FASTA scores: opt: 242, E(): 3.6e-08, (30.35% identity in 270 aa overlap); Q9RK95|SCF1.09 PUTATIVE HYDROLASE from Streptomyces coelicolor (258 aa), FASTA scores: opt: 239, E(): 4.9e-08,(30.75% identity in 247 aa overlap); Q9HZ14|PA3226 PROBABLE HYDROLASE from Pseudomonas aeruginosa (275 aa),FASTA scores: opt: 226, E(): 3.4e-07, (26.6% identity in 252 aa overlap); Q9HPT9|EST|VNG1474G CARBOXYLESTERASE from Halobacterium sp. strain NRC-1 (274 aa), FASTA scores: opt: 215, E(): 1.7e-06, (26.95% identity in 256 aa overlap); etc.	Q7TW47	No	intermediary metabolism and respiration								Q7TW47	A0A1R3Y4R8				Rv3591c		Rv3591c			
NC_002945.3	Mycobrowser_v4	CDS	3986282	3987100	.	-	0	Mb3630c	Mb3630c		conserved protein	Mb3630c, -, len: 272 aa. Equivalent to Rv3600c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 272 aa overlap). Conserved hypothetical protein, identical to Q9CD56|ML0232 HYPOTHETICAL PROTEIN from Mycobacterium leprae (274 aa),FASTA scores: opt: 1585, E(): 1.3e-92, (90.5% identity in 274 aa overlap). Also highly similar to others e.g. Q9X8N6|SCE94.31c from Streptomyces coelicolor (265 aa) FASTA scores: opt: 878, E(): 3.9e-48, (51.5% identity in 268 aa overlap); and Q9KGH5|BH0086 from Bacillus halodurans (254 aa), FASTA scores: opt: 611, E(): 2.4e-31,(37.5% identity in 264 aa overlap). And similar to various bacterial proteins e.g. Q9F985 PUTATIVE 32 KDA REPLICATION PROTEIN from Bacillus stearothermophilus (258 aa), FASTA scores: opt: 594, E(): 2.8e-30, (37.45% identity in 267 aa overlap); P37564|YACB_BACSU from Bacillus subtilis (233 aa), FASTA scores: opt: 522, E(): 8.8e-26, (38.95% identity in 213 aa overlap); Q9RX54|DR0461 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (262 aa), FASTA scores: opt: 503, E(): 1.5e-24, (38.45% identity in 268 aa overlap); etc.	X2BPW6,Q7TW42	No	conserved hypotheticals								X2BPW6,Q7TW42	Q7TW42				Rv3600c		Rv3600c			
NC_002945.3	Mycobrowser_v4	CDS	3988448	3989359	.	-	0	Mb3633c	Mb3633c		CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH PROTEIN	Mb3633c, -, len: 303 aa. Equivalent to Rv3603c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Conserved hypothetical ala-, leu-rich protein, identical except at N-terminus (really different) to AAK48066|MT3708 CHALCONE/STILBENE SYNTHASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (361 aa) FASTA scores: opt: 1742, E(): 8.3e-95, (100.0% identity in 275 aa overlap). Equivalent to O69525|MLCB2548.02c|ML0229 HYPOTHETICAL 32.7 KDA PROTEIN from Mycobacterium leprae (309 aa), FASTA scores: opt: 947, E(): 2.4e-48, (67.85% identity in 311 aa overlap). Also highly similar to Q9X845|SCE126.02c HYPOTHETICAL 42.2 KDA PROTEIN from Streptomyces coelicolor (420 aa), FASTA scores: opt: 683,E(): 8.5e-33, (49.3% identity in 284 aa overlap).	Q7TW41	No	conserved hypotheticals							IPR008927,IPR016040,IPR018931,IPR019665	Q7TW41	A0A1R3Y4M9				Rv3603c		Rv3603c			
NC_002945.3	Mycobrowser_v4	CDS	3989544	3990737	.	-	0	Mb3634c	Mb3634c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN RICH IN ALANINE AND ARGININE AND PROLINE	Mb3634c, -, len: 397 aa. Equivalent to Rv3604c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Probable conserved ala-, arg-, pro-rich transmembrane protein, equivalent to O69526|MLCB2548.03c|ML0228 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (432 aa), FASTA scores: opt: 869,E(): 2.9e-31, (59.7% identity in 432 aa overlap). Contains two possible membrane-spanning domains. N-terminus shortened since first submission (previously 462 aa).	Q7TW40	No	cell wall and cell processes								Q7TW40	A0A1R3Y4P9				Rv3604c		Rv3604c			
NC_002945.3	Mycobrowser_v4	CDS	4002088	4003140	.	-	0	Mb3650c	Mb3650c		CONSERVED HYPOTHETICAL PROTEIN	Mb3650c, -, len: 350 aa. Equivalent to Rv3626c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 350 aa overlap). Conserved hypothetical protein, similar to Q9X8I7|SCE9.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (375 aa) FASTA scores: opt: 720, E(): 2.2e-38, (41.55% identity in 361 aa overlap); and shows some similarity to Q9HPS0|VNG1497C HYPOTHETICAL PROTEIN (317 aa) FASTA scores: opt: 226, E(): 4.5e-07, (29.7% identity in 347 aa overlap). Contains neutral zinc metallopeptidases,zinc-binding region signature (PS00142).	Q7TW32	No	conserved hypotheticals							IPR018766,IPR022454	Q7TW32	A0A1R3Y4S6				Rv3626c		Rv3626c			
NC_002945.3	Mycobrowser_v4	CDS	4048174	4048692	.	+	0	Mb3693	Mb3693		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3693, -, len: 172 aa. Equivalent to Rv3669, len: 172 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 172 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CB97|ML2296 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 863, E(): 1.4e-47, (77.35% identity in 181 aa overlap). Also similar to two PUTATIVE INTEGRAL MEMBRANE TRANSPORT PROTEINS from Streptomyces coelicolor; Q9X930|SCH5.28 (162 aa) FASTA scores: opt: 265, E(): 6.3e-10, (37.4% identity in 155 aa overlap); and Q9X9W1|SCI7.29c (165 aa), FASTA scores: opt: 194, E(): 1.9e-05, (30.6% identity in 134 aa overlap). Contains two hydrophobic stretches in centre.	Q7TVZ5	No	cell wall and cell processes							IPR009937	Q7TVZ5	A0A1R3Y4S2				Rv3669		Rv3669			
NC_002945.3	Mycobrowser_v4	CDS	4003137	4004522	.	-	0	Mb3651c	Mb3651c		conserved protein	Mb3651c, -, len: 461 aa. Equivalent to Rv3627c,len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 461 aa overlap). Hypothetical ala-rich protein which may have cleavable signal peptide at N-terminal end. Equivalent to O69539|MLCB2548.20c|ML0211 HYPOTHETICAL 47.2 KDA PROTEIN from Mycobacterium leprae (461 aa), FASTA scores: opt: 2295, E(): 3.5e-116, (76.2% identity in 462 aa overlap); and C-terminal end shows similarity with O05758|MLCB5.28c HYPOTHETICAL 24.1 KDA PROTEIN from Mycobacterium leprae (225 aa), FASTA scores: opt: 268, E(): 1.8e-07, (32.25% identity in 220 aa overlap). Also similar (or with similarity) to various proteins (notably penicillin binding proteins) e.g. Q9X8I8|SCE9.15c HYPOTHETICAL 45.9 KDA PROTEIN from Streptomyces coelicolor (459 aa) FASTA scores: opt: 707,E(): 8.3e-31, (35.75% identity in 439 aa overlap); Q9Z541|SC9B2.18c PUTATIVE CARBOXYPEPTIDASE from Streptomyces coelicolor (451 aa), FASTA scores: opt: 450,E(): 5.3e-17, (31.75% identity in 469 aa overlap); Q9JVV4|NMA0665 PUTATIVE PEPTIDASE from Neisseria meningitidis (serogroup A) (or Q9JY10|NMB1797 from serogroup B) (469 aa), FASTA scores: opt: 269, E(): 3e-07,(26.15% identity in 463 aa overlap); O85665|PBP3 PENICILLIN BINDING PROTEIN 3 from Neisseria gonorrhoeae (469 aa), FASTA scores: opt: 265, E(): 4.9e-07, (31.85% identity in 201 aa overlap); P45161|PBP4_HAEIN|DACB|HI1330 PENICILLIN-BINDING PROTEIN 4 PRECURSOR/PEPTIDASE (479 aa) FASTA scores: opt: 230, E(): 3.8e-05, (27.9% identity in 394 aa overlap); P24228|PBP4_ECOLI|DACB|B3182 PENICILLIN-BINDING PROTEIN 4 PRECURSOR from Escherichia coli strain K12 (477 aa), FASTA scores: opt: 166, E(): 0.1, (28.2% identity in 408 aa overlap); etc.	Q7TW31	No	conserved hypotheticals							IPR000667,IPR012338	Q7TW31	A0A1R3Y4U0				Rv3627c		Rv3627c			
NC_002945.3	Mycobrowser_v4	CDS	4005194	4006291	.	-	0	Mb3653c	Mb3653c		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3653c, -, len: 365 aa. Equivalent to Rv3629c,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 365 aa overlap). Probable conserved integral membrane protein, equivalent to O69543|MLCB2548.26|ML0205 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (356 aa), FASTA scores: opt: 1547,E(): 3e-89, (66.2% identity in 361 aa overlap). Also similar to other membrane and hypothetical proteins e.g. CAC37534|SCIF3.15c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (363 aa), FASTA scores: opt: 819,E(): 7.7e-44, (51.55% identity in 351 aa overlap); Q9CGK3|YKJK HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (339 aa) FASTA scores: opt: 683, E(): 2.2e-35, (48.3% identity in 350 aa overlap); Q9KY24|SCC8A.24c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (380 aa) FASTA scores: opt: 528, E(): 1.1e-25, (50.25% identity in 372 aa overlap); Q9RJH8|SCF73.09 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (370 aa) FASTA scores: opt: 439, E(): 3.9e-20, (50.2% identity in 384 aa overlap); Q9PE36|XF1192 INTEGRAL MEMBRANE PROTEIN from Xylella fastidiosa (341 aa), FASTA scores: opt: 337, E(): 8.3e-14, (47.65% identity in 361 aa overlap); etc.	Q7TW30	No	cell wall and cell processes							IPR007427	Q7TW30	A0A1R3Y4N4				Rv3629c		Rv3629c			
NC_002945.3	Mycobrowser_v4	CDS	4006412	4007707	.	+	0	Mb3654	Mb3654		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3654, -, len: 431 aa. Equivalent to Rv3630, len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 431 aa overlap). Probable conserved integral membrane, highly similar to P71789|YF10_MYCTU|Rv1510|MTCY277.32 HYPOTHETICAL 44.3 KDA PROTEIN from Mycobacterium tuberculosis (432 aa) FASTA scores: opt: 1940, E(): 2.3e-103, (70.75% identity in 424 aa overlap). Note that N-terminal end is highly similar to AAK45825|MT1558 HYPOTHETICAL 18.1 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (172 aa) FASTA scores: opt: 649, E(): 4.2e-30, (61.65% identity in 167 aa overlap); and C-terminal end is highly similar to AAK45826|MT1560 HYPOTHETICAL 25.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 1269, E(): 2.6e-65, (76.7% identity in 253 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, so could be a protease.	X2BPF4,P59985	No	cell wall and cell processes								X2BPF4,P59985	P59985				Rv3630		Rv3630			
NC_002945.3	Mycobrowser_v4	CDS	4007751	4008476	.	+	0	Mb3655	Mb3655		possible transferase (possibly glycosyltransferase)	Mb3655, -, len: 241 aa. Equivalent to Rv3631, len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Possible transferase (EC 2.-.-.-), more specifically a glycosyltransferase (EC 2.4.-.-), equivalent to O69542|MLCB2548.24c|ML0207 PUTATIVE TRANSFERASE (PUTATIVE GLYCOSYLTRANSFERASE) from Mycobacterium leprae (239 aa) FASTA scores: opt: 1303,E(): 2.8e-72, (81.2% identity in 239 aa overlap). Also similar to many dolichyl-phosphate mannose synthases and hypothetical proteins e.g. O59263|PH1585 HYPOTHETICAL 34.6 KDA PROTEIN from Pyrococcus horikoshii (313 aa), FASTA scores: opt: 472, E(): 1.2e-21, (36.65% identity in 232 aa overlap); Q9V152|PAB1971 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE from Pyrococcus abyssi (287 aa), FASTA scores: opt: 467, E(): 2.3e-21, (35.85% identity in 223 aa overlap); Q58619|YC22_METJA|MJ1222 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (243 aa), FASTA scores: opt: 400, E(): 2.4e-17, (33.35% identity in 228 aa overlap); O26474|MTH374 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED PROTEIN from Methanobacterium thermoautotrophicum (291 aa) FASTA scores: opt: 354, E(): 1.7e-14, (33.5% identity in 218 aa overlap); O26239|MTH136 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE from Methanobacterium thermoautotrophicum (220 aa), FASTA scores: opt: 345, E(): 4.8e-14, (33.5% identity in 221 aa overlap); etc.	Q7TW29	No	intermediary metabolism and respiration							IPR001173	Q7TW29	A0A1R3Y4Q7				Rv3631		Rv3631			
NC_002945.3	Mycobrowser_v4	CDS	4008473	4008817	.	+	0	Mb3656	Mb3656		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb3656, -, len: 114 aa. Equivalent to Rv3632, len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Possible conserved membrane protein, equivalent to O69541|MLCB2548.23c|ML0208 HYPOTHETICAL 12.9 KDA PROTEIN (PUTATIVE MEMBRANE PROTEIN) from Mycobacterium leprae (113 aa), FASTA scores: opt: 594, E(): 7.1e-35, (82.0% identity in 111 aa overlap).	Q7TW28	No	cell wall and cell processes							IPR019277	Q7TW28	A0A1R3Y4R7				Rv3632		Rv3632			
NC_002945.3	Mycobrowser_v4	CDS	4009028	4009903	.	+	0	Mb3657	Mb3657		conserved protein	Mb3657, -, len: 291 aa. Equivalent to Rv3633, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Conserved hypothetical protein, similar to Q9X5S6|MMCH from Streptomyces lavendulae (254 aa), FASTA scores: opt: 368,E(): 3.2e-16, (35.05% identity in 194 aa overlap); Q9APW1 HYPOTHETICAL 32.7 KDA PROTEIN from Pseudomonas aeruginosa (295 aa), FASTA scores: opt: 359, E(): 1.3e-15, (37.65% identity in 170 aa overlap); Q9APV4 HYPOTHETICAL 34.1 KDA PROTEIN from Pseudomonas aeruginosa (309 aa), FASTA scores: opt: 316, E(): 7.6e-13, (28.65% identity in 262 aa overlap). And some similarity to Q9HGD7|FUM9 FUM9P from Gibberella moniliformis (300 aa), FASTA scores: opt: 254,E(): 6.5e-09, (29.95% identity in 157 aa overlap); and P47181|YJ9S_YEAST|YJR154W|J2240 HYPOTHETICAL 39.0 KDA PROTEIN from Saccharomyces cerevisiae (Baker's yeast) (346 aa), FASTA scores: opt: 190, E(): 8.5e-05, (26.75% identity in 127 aa overlap). Also similar to P71782|YF01_MYCTU|Rv1501|MT1550|MTCY277.23 from Mycobacterium tuberculosis (273 aa), FASTA scores: opt: 286, E(): 5.5e-11, (27.5% identity in 280 aa overlap).	X2BP77	No	conserved hypotheticals								X2BP77	P67773				Rv3633		Rv3633			
NC_002945.3	Mycobrowser_v4	CDS	4018753	4019958	.	-	0	Mb3668c	Mb3668c		possible dna polymerase	Mb3668c, -, len: 401 aa. Equivalent to Rv3644c,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Possible DNA polymerase (EC 2.7.7.-), equivalent to O69546|MLCB2548.29c|ML0202 HYPOTHETICAL 42.7 KDA PROTEIN from Mycobacterium leprae (405 aa), FASTA scores: opt: 2180, E(): 6.1e-116, (84.4% identity in 404 aa overlap). Similar (in totality or in first 200 aa) to DNA polymerases III, delta' or gamma subunit, e.g. Q9X906|SCH5.03c PUTATIVE DNA POLYMERASE from Streptomyces coelicolor (401 aa), FASTA scores: opt: 1022, E(): 1.5e-50, (47.05% identity in 404 aa overlap); Q9RRS5|DR2410 DNA POLYMERASE III, TAU/GAMMA SUBUNIT from Deinococcus radiodurans (615 aa), FASTA scores: opt: 370,E(): 1.3e-13, (29.95% identity in 394 aa overlap); P28631|HOLB_ECOLI|B1099 DNA POLYMERASE III, DELTA' SUBUNIT from Escherichia coli strain K12 (334 aa), FASTA scores: opt: 345, E(): 2.2e-12, (33.45% identity in 239 aa overlap); Q9JTS1|DNAZX|NMA1656 DNA POLYMERASE III TAU AND GAMMA CHAINS from Neisseria meningitidis (serogroup A) (709 aa), FASTA scores: opt: 346, E(): 3.3e-12, (28.55% identity in 364 aa overlap); etc.	Q7TW17	No	information pathways							IPR003593,IPR004622,IPR008921,IPR027417	Q7TW17	A0A1R3Y599				Rv3644c		Rv3644c			
NC_002945.3	Mycobrowser_v4	CDS	4010871	4012646	.	+	0	Mb3659	Mb3659		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3659, -, len: 591 aa. Equivalent to Rv3635, len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 591 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 25 aa, to O69545|ML0203|MLCB2548.28 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (569 aa), FASTA scores: opt: 2933,E(): 4.6e-173, (77.0% identity in 569 aa overlap).	Q7TW26	No	cell wall and cell processes								Q7TW26	A0A1R3Y4S4				Rv3635		Rv3635			
NC_002945.3	Mycobrowser_v4	CDS	4012989	4013336	.	+	0	Mb3660	Mb3660		possible transposase	Mb3660, -, len: 115 aa. Equivalent to Rv3636, len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Possible transposase,weakly similar to others e.g. O69924|SC3C8.12 PUTATIVE TRANSPOSASE from Streptomyces coelicolor (487 aa) FASTA scores: opt: 132, E(): 0.12, (33.05% identity in 112 aa overlap); O96916 TC1-LIKE TRANSPOSASE from Anopheles gambiae (African malaria mosquito) (332 aa), FASTA scores: opt: 117, E(): 0.84, (30.75% identity in 91 aa overlap); Q9R2U5|IS466A|IS466A-ORF|TNPA|IS469|SCP1.276 TRANSPOSASE (INSERTION ELEMENT IS466S TRANSPOSASE) from Streptomyces coelicolor (513 aa), FASTA scores: opt: 114, E(): 2,(30.5% identity in 82 aa overlap); etc. Similar in part to P96288|Rv2943|MTCY24G1.06c HYPOTHETICAL 45.8 KDA PROTEIN from Mycobacterium tuberculosis (413 aa), FASTA scores: opt: 533, E(): 1.4e-28, (74.55% identity in 110 aa overlap). Contains possible helix-turn-helix motif from aa 19-40 (+4.98 SD).	Q7TW25	No	insertion seqs and phages							IPR011991,IPR013249	Q7TW25	A0A1R3Y4T7				Rv3636		Rv3636			
NC_002945.3	Mycobrowser_v4	CDS	4013721	4014221	.	+	0	Mb3661	Mb3661		possible transposase	Mb3661, -, len: 166 aa. Equivalent to Rv3637, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Possible transposase. C-terminal end highly similar to Q9RLQ9|ISTA PUTATIVE TRANSPOSASE A (FRAGMENT) from Mycobacterium bovis (102 aa), FASTA scores: opt: 397, E(): 1.4e-19, (58.8% identity in 102 aa overlap). Weakly similar to others e.g. Q9KJ02 PUTATIVE TRANSPOSASE (FRAGMENT) from Polyangium cellulosum (329 aa), FASTA scores: opt: 191, E(): 1.6e-05, (32.1% identity in 134 aa overlap); Q9LCU2|ISTA COINTEGRASE from Pseudomonas aeruginosa (382 aa) FASTA scores: opt: 144,E(): 0.024, (26.8% identity in 123 aa overlap); P15025|ISTA_PSEAE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS21 from Pseudomonas aeruginosa (390 aa), FASTA scores: opt: 144, E(): 0.025, (26.85% identity in 123 aa overlap); etc. Also highly similar to C-terminal end of P96288|Rv2943|MTCY24G1.06c HYPOTHETICAL 45.8 KDA PROTEIN from Mycobacterium tuberculosis (413 aa) FASTA scores: opt: 722, E(): 1.5e-40, (63.7% identity in 168 aa overlap).	Q7TW24	No	insertion seqs and phages								Q7TW24	A0A1R3Y4U8				Rv3637		Rv3637			
NC_002945.3	Mycobrowser_v4	CDS	1716486	1717052	.	+	0	Mb1558	Mb1558		conserved protein	Mb1558, -, len: 188 aa. Equivalent to Rv1531, len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 188 aa overlap). Conserved hypothetical protein, similar to Rv0464c|MTV038.08c (190 aa), FASTA scores: E(): 4.8e-10, (30.9% identity in 175 aa overlap).	Q7TZX7,A0A1R3XYK1	No	conserved hypotheticals			A0A1R3XYK1				IPR003779	Q7TZX7					Rv1531		Rv1531			
NC_002945.3	Mycobrowser_v4	CDS	4014221	4014967	.	+	0	Mb3662	Mb3662		possible transposase	Mb3662, -, len: 248 aa. Equivalent to Rv3638, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Possible transposase,highly similar to Q9RLQ8|ISTB ISTB PROTEIN from Mycobacterium bovis (266 aa), FASTA scores: opt: 784, E(): 4e-46, (78.0% identity in 259 aa overlap); and similar to others e.g. P15026|ISTB_PSEAE INSERTION SEQUENCE IS21 PUTATIVE ATP-BINDING PROTEIN from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 420, E(): 2.2e-21, (38.8% identity in 255 aa overlap); Q45619|ISTB_BACST INSERTION SEQUENCE IS5376 PUTATIVE ATP-BINDING PROTEIN from Bacillus stearothermophilus (251 aa), FASTA scores: opt: 402, E(): 3.6e-20, (34.5% identity in 232 aa overlap); P15026|ISTB_ECOLI ISTB PROTEIN from Escherichia coli (265 aa), FASTA scores: opt: 419, E(): 8e-23, (38.8% identity in 255 aa overlap); etc. C-terminus highly similar to C-terminus of P96287|Rv2944|MTCY24G1.05 HYPOTHETICAL 25.5 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (alias AAK47343|MT3016 IS1533, ORFB from Mycobacterium tuberculosis strain CDC1551) (238 aa), FASTA scores: opt: 784, E(): 3.6e-46, (87.4% identity in 135 aa overlap).	Q7TW23	No	insertion seqs and phages							IPR002611,IPR027417,IPR028350	Q7TW23	A0A1R3Y4P5				Rv3638		Rv3638			
NC_002945.3	Mycobrowser_v4	CDS	4015121	4015687	.	-	0	Mb3663c	Mb3663c		CONSERVED HYPOTHETICAL PROTEIN	Mb3663c, -, len: 188 aa. Equivalent to Rv3639c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 188 aa overlap). Hypothetical protein,with C-terminus highly similar to N-terminus of P95044|Rv0698|MTCY210.15 HYPOTHETICAL 22.3 KDA PROTEIN from Mycobacterium tuberculosis (203 aa), FASTA scores: opt: 224, E(): 4.5e-07, (54.8% identity in 73 aa overlap).	Q7TW22	No	conserved hypotheticals								Q7TW22	A0A1R3Y4P6				Rv3639c		Rv3639c			
NC_002945.3	Mycobrowser_v4	CDS	4015757	4016986	.	-	0	Mb3664c	Mb3664c		probable transposase	Mb3664c, -, len: 409 aa. Equivalent to Rv3640c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 409 aa overlap). Probable transposase,highly similar to others e.g. Q48882 TRANSPOSASE from Mycobacterium avium (411 aa) FASTA scores: opt: 1574, E(): 6.2e-93, (59.75% identity in 400 aa overlap); Q9AKV5 PUTATIVE TRANSPOSASE (FRAGMENT) from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 1566, E(): 1.9e-92, (60.0% identity in 395 aa overlap); Q48368 TRANSPOSASE from Mycobacterium avium (410 aa), FASTA scores: opt: 1561, E(): 4.1e-92, (59.4% identity in 404 aa overlap); etc.	Q7TW21	No	insertion seqs and phages							IPR001207	Q7TW21	A0A1R3Y4R9				Rv3640c		Rv3640c			
NC_002945.3	Mycobrowser_v4	CDS	4020044	4021693	.	+	0	Mb3669	Mb3669		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3669, -, len: 549 aa. Equivalent to Rv3645, len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 549 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 20 aa, to O69547|ML0201|MLCB2548.30 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (530 aa), FASTA scores: opt: 2958,E(): 1.5e-168, (85.5% identity in 530 aa overlap). Also closely related to several other hypothetical M. tuberculosis proteins, e.g. Q10631|YD18_MYCTU|Rv1318c|MT1359|MTCY130.03c (541 aa) FASTA scores: opt: 1105, E(): 2.7e-58, (39.35% identity in 506 aa overlap); Q10633|YD20_MYCTU|Rv1320c|MT1362|MTCY130.05c (567 aa) FASTA scores: opt: 1031, E(): 7.1e-54, (38.1% identity in 509 aa overlap); Q10632|YD19_MYCTU|Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 1016, E(): 5.3e-53, (37.1% identity in 531 aa overlap); etc. Also similar at C-terminal end to many adenylate cyclases (EC 4.6.1.1) e.g. O83498|TP0485 from Treponema pallidum (614 aa) FASTA scores: opt: 365, E(): 3.2e-14, (31.55% identity in 317 aa overlap); P94180|CYAA from Anabaena sp. strain PCC 7120 (735 aa), FASTA scores: opt: 364, E(): 4.2e-14, (32.75% identity in 229 aa overlap); etc.	Q7TW16	No	cell wall and cell processes							IPR001054,IPR003660	Q7TW16	A0A1R3Y4T6				Rv3645		Rv3645			
NC_002945.3	Mycobrowser_v4	CDS	4024847	4025425	.	-	0	Mb3671c	Mb3671c		CONSERVED HYPOTHETICAL PROTEIN	Mb3671c, -, len: 192 aa. Equivalent to Rv3647c,len: 192 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 192 aa overlap). Hypothetical protein,equivalent to O69549|MLCB2548.32c|ML0199 HYPOTHETICAL 21.2 KDA PROTEIN from Mycobacterium leprae (200 aa), FASTA scores: opt: 1029, E(): 9e-58, (80.4% identity in 199 aa overlap).	Q7TW15	No	conserved hypotheticals								Q7TW15	A0A1R3Y4V4				Rv3647c		Rv3647c			
NC_002945.3	Mycobrowser_v4	CDS	4038612	4039382	.	-	0	Mb3686c	Mb3686c		CONSERVED HYPOTHETICAL PROTEIN	Mb3686c, -, len: 256 aa. Equivalent to Rv3662c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 256 aa overlap). Conserved hypothetical protein, equivalent to Q9CB99|ML2289 HYPOTHETICAL PROTEIN from Mycobacterium leprae (256 aa) FASTA scores: opt: 1255, E(): 3.3e-69, (78.05% identity in 255 aa overlap). Also similar to Q9X924|SCH5.22c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (274 aa), FASTA scores: opt: 289, E(): 1.8e-10, (39.25% identity in 270 aa overlap).	Q7TW01	No	conserved hypotheticals							IPR003812	Q7TW01	A0A1R3Y4U6				Rv3662c		Rv3662c			
NC_002945.3	Mycobrowser_v4	CDS	2524286	2524585	.	+	0	Mb2294	Mb2294		CONSERVED HYPOTHETICAL PROTEIN	Mb2294, -, len: 99 aa. Equivalent to Rv2271, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Conserved hypothetical protein; some similarity to hypothetical protein AAK01340.1|AF265275_3 (AF265275) from uncultured organism Pu8 (104 aa) E= 4e-10, (34% identity in 91 aa overlap)	X2BKL0,P64968	No	conserved hypotheticals			P64968					X2BKL0					Rv2271		Rv2271			
NC_002945.3	Mycobrowser_v4	CDS	4026018	4028333	.	+	0	Mb3673	Mb3673		probable helicase	Mb3673, -, len: 771 aa. Equivalent to Rv3649, len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 771 aa overlap). Probable helicase (EC 3.6.-.-), similar to many (known or hypothetical) ATP-dependent helicases e.g. Q9X915|SCH5.13 PUTATIVE HELICASE from Streptomyces coelicolor (815 aa) FASTA scores: opt: 2550, E(): 9.6e-139, (52.45% identity in 774 aa overlap); Q05549|YDR291W|D9819.1 PROTEIN SIMILAR TO SEVERAL DNA HELICASES from Saccharomyces cerevisiae (Baker's yeast) (1077 aa), FASTA scores: opt: 1161, E(): 5.9e-59, (31.05% identity in 780 aa overlap); P50830|YPRA_BACSU HYPOTHETICAL HELICASE from Bacillus subtilis (749 aa), FASTA scores: opt: 1154, E(): 1.1e-58,(34.05% identity in 734 aa overlap); Q9KC10|BH1764 ATP-DEPENDENT RNA HELICASE from Bacillus halodurans (764 aa), FASTA scores: opt: 1122, E(): 8e-57, (32.3% identity in 759 aa overlap); etc. SEEMS SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY, AND TO HELICASE C-TERMINAL DOMAIN.	Q7TW14	No	information pathways							IPR001650,IPR011545,IPR014001,IPR018973,IPR022307,IPR027417	Q7TW14	A0A1R3Y4Q3				Rv3649		Rv3649			
NC_002945.3	Mycobrowser_v4	CDS	4034282	4035340	.	-	0	Mb3683c	Mb3683c		CONSERVED HYPOTHETICAL PROTEIN	Mb3683c, -, len: 352 aa. Equivalent to Rv3659c,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein, highly similar, but always shorter (various lengths) at N-terminus, to Q9X921|SCH5.19c PUTATIVE SECRETORY PROTEIN from Streptomyces coelicolor (523 aa), FASTA scores: opt: 1287, E(): 5.3e-66, (59.85% identity in 351 aa overlap); Q9HW98|PA4302 PROBABLE TYPE II SECRETION SYSTEM PROTEIN from Pseudomonas aeruginosa (421 aa), FASTA scores: opt: 776, E(): 5.4e-37, (42.8% identity in 320 aa overlap); AAK65510|CPAF2 PROBABLE CPAF2 PILUS ASSEMBLY PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (497 aa) FASTA scores: opt: 769, E(): 1.5e-36, (40.45% identity in 309 aa overlap); Q9KY93|SCK15.11 PUTATIVE SECRETORY PROTEIN from Streptomyces coelicolor (445 aa), FASTA scores: opt: 751,E(): 1.5e-35, (38.15% identity in 333 aa overlap); etc. Contains PS00017 ATP/GTP binding site motif A (P-loop). Note that previously known as trbB.	Q7TW04	No	conserved hypotheticals							IPR001482,IPR022399,IPR027417	Q7TW04	A0A1R3Y4R4				Rv3659c		Rv3659c			
NC_002945.3	Mycobrowser_v4	CDS	4035442	4036494	.	-	0	Mb3684c	Mb3684c		CONSERVED HYPOTHETICAL PROTEIN	Mb3684c, -, len: 350 aa. Equivalent to Rv3660c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 350 aa overlap). Conserved hypothetical protein, similar to O33612 PROTEIN CONCERNED IN INHIBITION OF MORPHOLOGICAL DIFFERENTIATION IN Streptomyces azureus from Streptomyces cyaneus (Streptomyces curacoi) (370 aa),FASTA scores: opt: 655, E(): 5.9e-31, (42.2% identity in 315 aa overlap); Q9X922|SCH5.20c PUTATIVE SEPTUM SITE DETERMINING PROTEIN from Streptomyces coelicolor (396 aa),FASTA scores: opt: 592, E(): 2.9e-27, (43.25% identity in 275 aa overlap). And shows some similarity to AAK65513|CPAE2 PROBABLE CPAE2 PILUS ASSEMBLY PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (586 aa) FASTA scores: opt: 212, E(): 5.1e-05, (25.75% identity in 295 aa overlap); and several cell division inhibitors or septum site-determining proteins. Equivalent to AAK48124 from Mycobacterium tuberculosis strain CDC1551 (261 aa) but longer 89 aa.	Q7TW03	No	virulence, detoxification, adaptation							IPR022521,IPR025501,IPR027417	Q7TW03	A0A1R3Y4T2				Rv3660c		Rv3660c			
NC_002945.3	Mycobrowser_v4	CDS	4036994	4037857	.	+	0	Mb3685	Mb3685		CONSERVED HYPOTHETICAL PROTEIN	Mb3685, -, len: 287 aa. Equivalent to Rv3661, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). Conserved hypothetical protein, highly similar to O33611|IMD_STRCN from Streptomyces cyaneus (Streptomyces curacoi) protein involved in inhibition of morphological differentiation in Streptomyces azureus (BELONGS TO THE SERB FAMILY) (277 aa) FASTA scores: opt: 1073, E(): 3.5e-61, (61.45% identity in 262 aa overlap); and Q9X923|SCH5.21 PUTATIVE MORPHOLOGICAL DIFFERENTIATION-ASSOCIATED PROTEIN from Streptomyces coelicolor (268 aa), FASTA scores: opt: 1057, E(): 3.6e-60, (61.45% identity in 262 aa overlap). Also similar to various bacterial proteins (principally serB-related proteins) e.g. Q49823|ML2424 HYPOTHETICAL SERB PROTEIN from Mycobacterium leprae (300 aa), FASTA scores: opt: 452, E(): 1.4e-21, (35.8% identity in 257 aa overlap); Q9WX12|SCE68.20 HYPOTHETICAL 32.0 KDA PROTEIN from Streptomyces coelicolor (298 aa), FASTA scores: opt: 415,E(): 3.1e-19, (33.55% identity in 280 aa overlap); Q9RIT2|SERB PHOSPHOSERINE PHOSPHATASE (FRAGMENT) from Streptomyces coelicolor (266 aa), FASTA scores: opt: 405,E(): 1.2e-18, (34.1% identity in 261 aa overlap); etc. Also similar to Q11169|Y505_MYCTU|Rv0505c|MTCY20G9.32c HYPOTHETICAL 39.5 KDA PROTEIN from Mycobacterium tuberculosis (373 aa), FASTA scores: opt: 454, E(): 1.2e-21, (35.15% identity in 276 aa overlap). BELONGS TO THE SERB FAMILY.	Q7TW02	No	virulence, detoxification, adaptation							IPR006383,IPR006385,IPR023214	Q7TW02	A0A1R3Y4U1				Rv3661		Rv3661			
NC_002945.3	Mycobrowser_v4	CDS	4066098	4066430	.	-	0	Mb3711c	Mb3711c		CONSERVED HYPOTHETICAL PROTEIN	Mb3711c, -, len: 110 aa. Equivalent to Rv3686c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Hypothetical protein,similar to P96893|Rv3288c|MTCY71.28c HYPOTHETICAL 15.2 KDA PROTEIN from Mycobacterium tuberculosis (and Mycobacterium bovis) (137 aa) FASTA scores: opt: 106, E(): 5.6, (29.1% identity in 79 aa overlap); and a few hypothetical proteins e.g. Q9GUV6|L2259.2 from Leishmania major (360 aa) FASTA scores: opt: 118, E(): 2.1, (28.7% identity in 101 aa overlap). Equivalent to AAK48155 from Mycobacterium tuberculosis strain CDC1551 (166 aa) but shorter 56 aa.	Q7TVX9	No	conserved hypotheticals								Q7TVX9	A0A1R3Y4Y3				Rv3686c		Rv3686c			
NC_002945.3	Mycobrowser_v4	CDS	4049669	4050862	.	-	0	Mb3695c	Mb3695c		membrane-associated serine protease	Mb3695c, -, len: 397 aa. Equivalent to Rv3671c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Possible serine protease membrane protein (EC 3.4.21.-), equivalent to Q9CB95|ML2298 PUTATIVE MEMBRANE-ASSOCIATED SERINE PROTEASE from Mycobacterium leprae (401 aa), FASTA scores: opt: 2061, E(): 2.3e-108, (80.9% identity in 398 aa overlap). Also similar to many serine proteases, but generally with extended N-terminus, e.g. Q9X932|SCH5.30c PUTATIVE SERINE PROTEASE (FRAGMENT) from Streptomyces coelicolor (385 aa),FASTA scores: opt: 835, E(): 1.2e-39, (39.9% identity in 386 aa overlap); Q9Z6T0|DEGP_CHLPN|HTRA|CPN0979|CP0877 PROBABLE SERINE PROTEASE DO-LIKE PRECURSOR from Chlamydia pneumoniae (Chlamydophila pneumoniae) (488 aa), FASTA scores: opt: 285, E(): 1e-08, (29.05% identity in 296 aa overlap); P73354|HTRA|SLR1204 SERINE PROTEASE from Synechocystis sp. strain PCC 6803 (452 aa), FASTA scores: opt: 284, E(): 1.1e-08, (29.55% identity in 308 aa overlap); Q9RWC4|DR0745 PERIPLASMIC SERINE PROTEASE,HTRA/DEGQ/DEGS FAMILY from Deinococcus radiodurans (366 aa), FASTA scores: opt: 271, E(): 4.9e-08, (35.45% identity in 206 aa overlap); etc. Also similar, but longer 114 aa at the N-terminus, to Q9S2P8|SC5F7.13 PUTATIVE PEPTIDASE from Streptomyces coelicolor (282 aa), FASTA scores: opt: 594, E(): 3.1e-26, (38.95% identity in 285 aa overlap). And similar, but longer 146 aa at the N-terminus, to O07175|PEPA|Rv0125|MTCI418B.07 from Mycobacterium tuberculosis (355 aa), FASTA scores: opt: 295, E(): 2.2e-09, (29.55% identity in 254 aa overlap); and Q9CCY9|ML2659 PROBABLE SECRETED SERINE PROTEASE from Mycobacterium leprae FASTA scores: opt: 286, E(): 6.9e-09,(30.6% identity in 255 aa overlap). Contains PS00135 Serine proteases, trypsin family, serine active site.	Q7TVZ3	No	intermediary metabolism and respiration							IPR001254,IPR001940,IPR003825,IPR009003,IPR015724,IPR018114	Q7TVZ3	A0A1R3Y4V3				Rv3671c		Rv3671c			
NC_002945.3	Mycobrowser_v4	CDS	4051821	4052504	.	-	0	Mb3697c	Mb3697c		POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN)	Mb3697c, -, len: 227 aa. Equivalent to Rv3673c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q9CB93|ML2300 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52,(71.15% identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA PROTEIN from Bacillus subtilis (181 aa), FASTA scores: opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa overlap); Q9RXW6|DR0189 THIOL:DISULFIDE INTERCHANGE PROTEIN from Deinococcus radiodurans (185 aa) FASTA scores: opt: 206, E(): 1.3e-05, (33.8% identity in 139 aa overlap); Q9I505|PA0953 PROBABLE THIOREDOXIN from Pseudomonas aeruginosa (154 aa), FASTA scores: opt: 180,E(): 0.00044, (34.85% identity in 109 aa overlap); Q9KCP7|BH1522 THIOREDOXIN (THIOL:DISULFIDE INTERCHANGE PROTEIN) from Bacillus halodurans (177 aa), FASTA scores: opt: 178, E(): 0.00064, (31.75% identity in 107 aa overlap); P43221|TLPA_BRAJA THIOL:DISULFIDE INTERCHANGE PROTEIN (CYTOCHROME C BIOGENESIS PROTEIN) from Bradyrhizobium japonicum (221 aa), FASTA scores: opt: 189,E(): 0.00017, (26.85% identity in 227 aa overlap); etc. Also similar to O06392|Rv0526|MTCY25D10.05 HYPOTHETICAL 23.2 KDA PROTEIN from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 160, E(): 0.0093, (27.45% identity in 142 aa overlap). Contains PS00194 Thioredoxin family active site. POSSIBLY BELONGS TO THE THIOREDOXIN FAMILY.	Q7TVZ1	No	intermediary metabolism and respiration							IPR005746,IPR012336,IPR013740,IPR017937	Q7TVZ1	A0A1R3Y6F2				Rv3673c		Rv3673c			
NC_002945.3	Mycobrowser_v4	CDS	4053349	4053726	.	+	0	Mb3699	Mb3699		POSSIBLE MEMBRANE PROTEIN	Mb3699, -, len: 125 aa. Equivalent to Rv3675, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Possible membrane protein, with some similarity to Q9YCZ2|APE1120 HYPOTHETICAL 11.7 KDA PROTEIN from Aeropyrum pernix (103 aa), FASTA scores: opt: 100, E(): 9, (40.0% identity in 55 aa overlap).	Q7TVZ0	No	cell wall and cell processes								Q7TVZ0	A0A1R3Y4V8				Rv3675		Rv3675			
NC_002945.3	Mycobrowser_v4	CDS	4054605	4055399	.	-	0	Mb3701c	Mb3701c		possible hydrolase	Mb3701c, -, len: 264 aa. Equivalent to Rv3677c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Possible hydrolase (EC 3.-.-.-), equivalent to Q9CB90|ML2303 PUTATIVE HYDROLASE from Mycobacterium leprae (262 aa) FASTA scores: opt: 1400, E(): 8.5e-81, (82.05% identity in 262 aa overlap). Also similar to other hydrolases and hypothetical proteins e.g. Q9XA41|SCH17.06c PUTATIVE HYDROLASE from Streptomyces coelicolor (256 aa) FASTA scores: opt: 609, E(): 3.9e-31, (54.65% identity in 247 aa overlap); Q9A9Q1|CC0923 METALLO-BETA-LACTAMASE FAMILY PROTEIN from Caulobacter crescentus (297 aa), FASTA scores: opt: 306, E(): 4.7e-12, (35.45% identity in 268 aa overlap); Q9Y392 CGI-83 PROTEIN from Homo sapiens (Human) (288 aa), FASTA scores: opt: 281, E(): 1.7e-10, (33.2% identity in 259 aa overlap); Q9F7R6 PREDICTED METALLOBETA LACTAMASE FOLD PROTEIN from uncultured proteobacterium EBAC31A08 (265 aa), FASTA scores: opt: 257, E(): 5.1e-09,(32.55% identity in 252 aa overlap); Q9PBI4|XF2160 HYDROXYACYLGLUTATHIONE HYDROLASE from Xylella fastidiosa (258 aa), FASTA scores: opt: 232, E(): 1.9e-07, (30.3% identity in 165 aa overlap); etc.	Q7TVY8	No	intermediary metabolism and respiration							IPR001279	Q7TVY8	A0A1R3Y4X3				Rv3677c		Rv3677c			
NC_002945.3	Mycobrowser_v4	CDS	4055406	4055861	.	-	0	Mb3702c	Mb3702c		conserved protein	Mb3702c, -, len: 151 aa. Equivalent to Rv3678c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, equivalent, but shorter 23 aa, to Q9CB89|ML2304 HYPOTHETICAL PROTEIN from Mycobacterium leprae (174 aa), FASTA scores: opt: 746, E(): 2.1e-40,(78.15% identity in 151 aa overlap). Also highly similar to many hypothetical proteins or transcription regulators e.g. Q9XA38|SCH17.09c from Streptomyces coelicolor (155 aa), FASTA scores: opt: 637, E(): 1.5e-33, (69.1% identity in 152 aa overlap); BAB48205|MLR0658 from Rhizobium loti (Mesorhizobium loti) (154 aa), FASTA scores: opt: 500,E(): 6.8e-25, (55.35% identity in 150 aa overlap); BAB50615|MLR3802 TRANSCRIPTION REGULATOR from Rhizobium loti (Mesorhizobium loti) (153 aa), FASTA scores: opt: 425,E(): 3.8e-20, (44.35% identity in 151 aa overlap); Q9U0W7|L7276.02 from Leishmania major (163 aa) FASTA scores: opt: 404, E(): 8.5e-19, (47.7% identity in 151 aa overlap); Q9UZA3|PAB0825 PUTATIVE TRANSLATION INITIATION INHIBITOR from Pyrococcus abyssi (127 aa), FASTA scores: opt: 108, E(): 3.7, (30.75% identity in 130 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature.	Q7TVY7	No	conserved hypotheticals							IPR006175,IPR013813	Q7TVY7	A0A1R3Y4U3				Rv3678c		Rv3678c			
NC_002945.3	Mycobrowser_v4	CDS	477698	478339	.	-	0	Mb0404c	Mb0404c		POSSIBLE SECRETED PROTEIN	Mb0404c, -, len: 213 aa. Equivalent to Rv0398c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Possible secreted protein, sharing no homology with other proteins. Has potential signal sequence with hydrophobic stretch from aa 7-25.	Q7U232,A0A1R3XV72	No	cell wall and cell processes			A0A1R3XV72					Q7U232					Rv0398c		Rv0398c			
NC_002945.3	Mycobrowser_v4	CDS	4082962	4084239	.	-	0	Mb3729c	Mb3729c		CONSERVED HYPOTHETICAL PROTEIN	Mb3729c, -, len: 425 aa. Equivalent to Rv3703c,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 425 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. Q9RD00|SCM1.44 from Streptomyces coelicolor (446 aa), FASTA scores: opt: 1480, E(): 1.4e-85, (53.9% identity in 421 aa overlap); P72841|SLR1303 from Synechocystis sp. strain PCC 6803 (410 aa), FASTA scores: opt: 533, E(): 4.5e-26, (36.6% identity in 429 aa overlap); Q9KYH7|SCC61A.16 from Streptomyces coelicolor (256 aa), FASTA scores: opt: 266, E(): 1.9e-09, (32.25% identity in 248 aa overlap); etc. Also similar to P95060|Rv0712|MTCY210.31 HYPOTHETICAL 32.7 KDA PROTEIN from Mycobacterium tuberculosis (299 aa), FASTA scores: opt: 243, E(): 5.9e-08, (30.6% identity in 304 aa overlap).	Q7TVW2	No	conserved hypotheticals							IPR005532,IPR016187,IPR017806,IPR024775	Q7TVW2	A0A1R3Y510				Rv3703c		Rv3703c			
NC_002945.3	Mycobrowser_v4	CDS	4056123	4057145	.	+	0	Mb3704	Mb3704		PROBABLE ANION TRANSPORTER ATPASE	Mb3704, -, len: 340 aa. Equivalent to Rv3679, len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). Probable anion transporting ATPase (EC 3.6.1.-), equivalent to Q9CB88|ML2305 PROBABLE ANION TRANSPORTER PROTEIN from Mycobacterium leprae (341 aa), FASTA scores: opt: 1810,E(): 2.1e-98, (84.15% identity in 341 aa overlap). Also highly similar to Q9XA36|SCH17.11 PUTATIVE ION-TRANSPORTING ATPASE from Streptomyces coelicolor (325 aa), FASTA scores: opt: 989, E(): 1.4e-50, (52.15% identity in 328 aa overlap); and similar to many anion transporting ATPases (principally arsenite transporters) e.g. O50593|ARSA_ACIMU ARSENICAL PUMP-DRIVING ATPASE (ARSENITE-TRANSLOCATING ATPASE) from Acidiphilium multivorum (583 aa), FASTA scores: opt: 225, E(): 8.1e-06,(25.1% identity in 319 aa overlap); AAG43231|ARSA ARSENITE ACITVATED ATPASE from Salmonella typhimurium plasmid R46 FASTA scores: opt: 211, E(): 5.3e-05, (26.95% identity in 267 aa overlap); P52145|ARA2_ECOLI|ARSA ARSENICAL PUMP-DRIVING ATPASE from Escherichia coli plasmid IncN R46 (583 aa), FASTA scores: opt: 211, E(): 5.3e-05, (26.95% identity in 267 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SOME SIMILARITY TO THE ARSA ATPASE FAMILY.	X2BPJ1,P65090	No	cell wall and cell processes								X2BPJ1,P65090	P65090				Rv3679		Rv3679			
NC_002945.3	Mycobrowser_v4	CDS	4057142	4058302	.	+	0	Mb3705	Mb3705		PROBABLE ANION TRANSPORTER ATPASE	Mb3705, -, len: 386 aa. Equivalent to Rv3680, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Probable anion transporting ATPase (EC 3.6.1.-), equivalent to Q9CB87|ML2306 PROBABLE ANION TRANSPORTER PROTEIN from Mycobacterium leprae (381 aa), FASTA scores: opt: 2131,E(): 6.5e-120, (88.1% identity in 370 aa overlap). Also highly similar, but shorter 29 aa, to Q9XA35|SCH17.12 PUTATIVE ION-TRANSPORTING ATPASE from Streptomyces coelicolor (481 aa), FASTA scores: opt: 1190, E(): 1.1e-63, (51.25% identity in 441 aa overlap); and similar to many anion transporting ATPases e.g. Q9UZA6|PAB1555 ANION TRANSPORTING ATPASE from Pyrococcus abyssi (330 aa) FASTA scores: opt: 242, E(): 3e-07, (24.6% identity in 297 aa overlap); Q9P7F8|SPAC1142.06 PUTATIVE ARSENITE-TRANSLOCATING from Schizosaccharomyces pombe (Fission yeast) (329 aa), FASTA scores: opt: 239, E(): 4.5e-07, (27.9% identity in 197 aa overlap); Q9HS79|ARSA1|VNG0365G ARSENICAL PUMP-DRIVING ATPASE from Halobacterium sp. strain NRC-1 (347 aa), FASTA scores: opt: 238, E(): 5.4e-07, (29.35% identity in 358 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TVY5	No	cell wall and cell processes							IPR016300,IPR025723,IPR027417	Q7TVY5	A0A1R3Y4W6				Rv3680		Rv3680			
NC_002945.3	Mycobrowser_v4	CDS	4077841	4079370	.	+	0	Mb3724	Mb3724		conserved protein	Mb3724, -, len: 509 aa. Equivalent to Rv3698, len: 509 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 509 aa overlap). Conserved hypothetical protein, highly similar to Q9AK89|SC10A9.15c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (505 aa), FASTA scores: opt: 1720, E(): 9e-103, (53.65% identity in 494 aa overlap). N-terminal end highly similar to CAC42136|SCBAC25F8.01 CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) from Streptomyces coelicolor (291 aa), FASTA scores: opt: 1078, E(): 8.7e-62, (52.6% identity in 291 aa overlap); and C-terminus highly similar to CAC44687|SCBAC17A6.42c (235 aa), FASTA scores: opt: 911,E(): 3.8e-51, (57.25% identity in 234 aa overlap).	Q7TVW7	No	conserved hypotheticals							IPR016602	Q7TVW7	A0A1R3Y4Y8				Rv3698		Rv3698			
NC_002945.3	Mycobrowser_v4	CDS	4061764	4062723	.	+	0	Mb3708	Mb3708		conserved protein	Mb3708, -, len: 319 aa. Equivalent to Rv3683, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 319 aa overlap). Conserved hypothetical protein, equivalent to Q9CB84|ML2309 HYPOTHETICAL PROTEIN from Mycobacterium leprae (330 aa) FASTA scores: opt: 1791, E(): 9e-107, (85.45% identity in 296 aa overlap). Also similar to Q9X935|SCH66.03 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa) FASTA scores: opt: 610, E(): 1.4e-31, (51.45% identity in 307 aa overlap); and Q9RRY7|YN45_DEIRA|DR2345 HYPOTHETICAL PROTEIN from Deinococcus radiodurans (305 aa) FASTA scores: opt: 243, E(): 3.2e-08, (31.1% identity in 315 aa overlap) and some similarity to other hypothetical bacterial proteins e.g. Q9CF81|YQED from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (278 aa) FASTA scores: opt: 200, E(): 1.6e-05, (26.85% identity in 287 aa overlap).	Q7TVY2	No	conserved hypotheticals							IPR004843	Q7TVY2	A0A1R3Y5C0				Rv3683		Rv3683			
NC_002945.3	Mycobrowser_v4	CDS	4062786	4063826	.	+	0	Mb3709	Mb3709		PROBABLE LYASE	Mb3709, -, len: 346 aa. Equivalent to Rv3684, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Probable lyase (EC 4.-.-.-), and more specifically a cysteine synthase (EC 4.2.99.8), highly similar to many lyases e.g. Q9K3N2|SCG20A.08c PUTATIVE LYASE from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1469, E(): 3.7e-85, (63.35% identity in 341 aa overlap) (shorter 31 aa at N-terminus); Q9KT44|VC1061 CYSTEINE SYNTHASE (EC 4.2.99.8)/CYSTATHIONINE BETA-SYNTHASE FAMILY PROTEIN from Vibrio cholerae (355 aa), FASTA scores: opt: 1366, E(): 1.1e-78, (63.25% identity in 321 aa overlap); Q9I4R3|PA1061 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (365 aa), FASTA scores: opt: 1311, E(): 3.2e-75, (59.8% identity in 341 aa overlap); Q9PH18|XF0128 CYSTEINE SYNTHASE from Xylella fastidiosa (390 aa), FASTA scores: opt: 1288, E(): 9.5e-74, (58.55% identity in 333 aa overlap) (shorter 34 aa at N-terminus); P55708|Y4XP_RHISN PUTATIVE CYSTEINE SYNTHASE from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (336 aa),FASTA scores: opt: 376, E(): 2.1e-16, (29.2% identity in 315 aa overlap); etc. Equivalent to AAK48153 from Mycobacterium tuberculosis strain CDC1551 (368 aa) but shorter 22 aa.	Q7TVY1	No	intermediary metabolism and respiration							IPR001926	Q7TVY1	A0A1R3Y4W2				Rv3684		Rv3684			
NC_002945.3	Mycobrowser_v4	CDS	4072073	4073395	.	+	0	Mb3718	Mb3718		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb3718, -, len: 440 aa. Equivalent to Rv3693, len: 440 aa (alternative start at 41910), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 440 aa overlap). Possible conserved membrane protein, similar to Q9KYW2|SCE33.21 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (436 aa), FASTA scores: opt: 875, E(): 3.3e-46,(56.25% identity in 448 aa overlap); Q9AAN0|CC0567 HYPOTHETICAL PROTEIN from Caulobacter crescentus (437 aa),FASTA scores: opt: 355, E(): 2.3e-14, (30.9% identity in 450 aa overlap); P73233|SLR2013 HYPOTHETICAL 48.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (435 aa),FASTA scores: opt: 340, E(): 1.9e-13, (29.7% identity in 438 aa overlap); etc. Equivalent to AAK48162 from Mycobacterium tuberculosis strain CDC1551 (475 aa) but shorter 35 aa. Also similar to other hypothetical proteins from Mycobacterium tuberculosis; MTV014_7; MTV007_27; and MTCY71_36 M.	Q7TVX2	No	cell wall and cell processes							IPR002881	Q7TVX2	A0A1R3Y5C2				Rv3693		Rv3693			
NC_002945.3	Mycobrowser_v4	CDS	4073469	4074461	.	-	0	Mb3719c	Mb3719c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3719c, -, len: 330 aa. Equivalent to Rv3694c,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Possible conserved transmembrane protein, highly similar to Q9KZM4|SCE34.01c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (335 aa), FASTA scores: opt: 1113, E(): 2.5e-60, (51.5% identity in 334 aa overlap); and similar to Q9KEW6|BH0733 HYPOTHETICAL PROTEIN from Bacillus halodurans (355 aa), FASTA scores: opt: 381, E(): 6.1e-16,(24.15% identity in 331 aa overlap); Q9AAM9|CC0568 HYPOTHETICAL PROTEIN from Caulobacter crescentus (332 aa),FASTA scores: opt: 352, E(): 3.3e-14, (30.3% identity in 310 aa overlap); P74166|SLR1478 HYPOTHETICAL 35.4 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (317 aa),FASTA scores: opt: 330, E(): 6.8e-13, (25.65% identity in 308 aa overlap); etc. C-terminal end shows similarity to O29631|AF0624|AE001061_10 CONSERVED HYPOTHETICAL PROTEIN (putative nifU protein) from Archaeoglobus fulgidus (185 aa), FASTA scores: opt: 154, E(): 0.021, (29.0% identity in 131 aa overlap). Equivalent to AAK48163 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but shorter 65 aa. Also some similarity to MTCY428_20 HYPOTHETICAL 43.7 KDA PROTEIN from Mycobacterium tuberculosis.	Q7TVX1	No	cell wall and cell processes							IPR002798	Q7TVX1	A0A1R3Y4X7				Rv3694c		Rv3694c			
NC_002945.3	Mycobrowser_v4	CDS	4097972	4098373	.	-	0	Mb3743c	Mb3743c		conserved protein	Mb3743c, -, len: 133 aa. Equivalent to Rv3716c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, equivalent to O69519|Y1B6_MYCLE|ML2330|MLCB2407.20 HYPOTHETICAL 11.9 KDA PROTEIN from Mycobacterium leprae (116 aa), FASTA scores: opt: 616, E(): 2.6e-21, (84.55% identity in 110 aa overlap). Also highly similar to hypothetical ~12 kDa proteins in the vicinity of recR from other bacteria e.g. Q9XAI3|YT3D_STRCO|SC66T3.30c HYPOTHETICAL 11.7 KDA PROTEIN from Streptomyces coelicolor (115 aa), FASTA scores: opt: 379, E(): 9.5e-11, (50.8% identity in 122 aa overlap); BAB56641|SAV0479 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (105 aa) FASTA scores: opt: 295, E(): 4.9e-07, (41.75% identity in 103 aa overlap); Q99WC4P24281|YAAK_BACSU HYPOTHETICAL 11.8 KDA PROTEIN IN DNAZ-RECR INTERGENIC REGION from Bacillus subtilis (107 aa), FASTA scores: opt: 272, E(): 5.3e-06,(39.4% identity in 104 aa overlap); P17577|YBAB_ECOLI|B0471|Z0588|ECS0524 from Escherichia coli strain K and O157:H7 (109 aa), FASTA scores: opt: 256, E(): 2.8e-05, (38.0% identity in 100 aa overlap); etc. Contains probable coiled-coil domain from aa 1-40. SEEMS TO BELONG TO THE UPF0133 FAMILY.	X2BPN2,P0A655	No	conserved hypotheticals								X2BPN2,P0A655	P0A655				Rv3716c		Rv3716c			
NC_002945.3	Mycobrowser_v4	CDS	4120394	4121452	.	+	0	Mb3759	Mb3759		conserved protein	Mb3759, -, len: 352 aa. Equivalent to Rv3732, len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Conserved hypothetical protein. The region between aa 175-352 is highly similar to the region between aa 72-257 of Q9KH39 HYPOTHETICAL 55.5 KDA PROTEIN from Mycobacterium smegmatis (511 aa), FASTA scores: opt: 1122, E(): 7.3e-63, (98.85% identity in 176 aa overlap). Also shows some similarity with Q55304 HYPOTHETICALK PROTEIN from Synechocystis sp. strain PCC 6803 (387 aa), FASTA scores: opt: 201, E(): 2.7e-05, (27.1% identity in 251 aa overlap); and P74254|SLR1173 HYPOTHETICAL 52.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (463 aa), FASTA scores: opt: 201, E(): 3.1e-05, (27.1% identity in 251 aa overlap). Also slightly similar to MTCY01B2_21 and DPO1_MYCTU DNA POLYMERASE I.	Q7TVT8	No	conserved hypotheticals							IPR019283	Q7TVT8	A0A1R3Y522				Rv3732		Rv3732			
NC_002945.3	Mycobrowser_v4	CDS	4074553	4075485	.	+	0	Mb3720	Mb3720		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb3720, -, len: 310 aa. Equivalent to Rv3695, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Possible conserved membrane protein, equivalent, but longer 88 aa, to Q9CB83|ML2312 POSSIBLE MEMBRANE PROTEIN from Mycobacterium leprae (196 aa), FASTA scores: opt: 898, E(): 5.2e-36,(71.05% identity in 190 aa overlap). Also highly similar to Q9KZM3|SCE34.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (318 aa), FASTA scores: opt: 740,E(): 2.4e-28, (43.25% identity in 319 aa overlap); and similar to P72718|SLR0254 HYPOTHETICAL 30.4 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (266 aa), FASTA scores: opt: 287, E(): 6.1e-07, (29.6% identity in 260 aa overlap); Q9HW83|PA4318 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 250,E(): 3.5e-05, (32.0% identity in 203 aa overlap); Q9KEW5|BH0734 HYPOTHETICAL PROTEIN from Bacillus halodurans (266 aa), FASTA scores: opt: 168, E(): 0.0047,(25.95% identity in 231 aa overlap); etc. C-terminal end shows some similarity to proline-rich proteins e.g. Q62106 PROLINE-RICH SALIVARY PROTEIN (FRAGMENT) from Mus musculus (Mouse) (188 aa) (36.1% identity in 97 aa overlap). Equivalent to AAK48164 from Mycobacterium tuberculosis strain CDC1551 (269 aa) but longer 41 aa.	Q7TVX0	No	cell wall and cell processes							IPR010432	Q7TVX0	A0A1R3Y501				Rv3695		Rv3695			
NC_002945.3	Mycobrowser_v4	CDS	4099275	4099718	.	-	0	Mb3745c	Mb3745c		conserved protein	Mb3745c, -, len: 147 aa. Equivalent to Rv3718c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein, equivalent to O69517|ML2332|MLCB2407.18 HYPOTHETICAL 15.5 KDA PROTEIN from Mycobacterium leprae (145 aa), FASTA scores: opt: 780, E(): 1.4e-44, (81.95% identity in 144 aa overlap). Also highly similar to Q9ZBJ2|SC9C7.18 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (147 aa) FASTA scores: opt: 475, E(): 1.7e-24, (52.05% identity in 146 aa overlap); and showing some similarity to various proteins e.g. P27538|PR2_PETCR PATHOGENESIS-RELATED PROTEIN 2 from Petroselinum crispum (Parsley) (Petroselinum hortense) (158 aa); P92918|ALL2_APIGR MAJOR ALLERGEN API G 2 from Apium graveolens (Celery) (159 aa); etc.	Q7TVV0	No	conserved hypotheticals							IPR014488,IPR019587,IPR023393	Q7TVV0	A0A1R3Y509				Rv3718c		Rv3718c			
NC_002945.3	Mycobrowser_v4	CDS	4159994	4161190	.	-	0	Mb3807c	Mb3807c		POSSIBLE AMINOTRANSFERASE	Mb3807c, -, len: 398 aa. Equivalent to Rv3778c,len: 398 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 398 aa overlap). Possible aminotransferase (EC 2.6.1.-), equivalent to Q9CD97|ML0117 HYPOTHETICAL PROTEIN from Mycobacterium leprae (398 aa) FASTA scores: opt: 2141, E(): 1.2e-123, (83.4% identity in 398 aa overlap). Also similar to others e.g. Q9K3K6|SCG20A.34 PUTATIVE AMINOTRANSFERASE from Streptomyces coelicolor (400 aa), FASTA scores: opt: 723,E(): 6.5e-37, (36.3% identity in 402 aa overlap); Q9KSS2|VC1184 NIFS-RELATED PROTEIN (AMINOTRANSFERASE-RELATED) from Vibrio cholerae (416 aa) FASTA scores: opt: 595, E(): 4.5e-29, (31.35% identity in 405 aa overlap); Q98NK4|MLR0102 AMINOTRANSFERASE from Rhizobium loti (Mesorhizobium loti) (425 aa), FASTA scores: opt: 563, E(): 4.2e-27, (29.4% identity in 408 aa overlap); Q9RY03|DR0151 NIFS-RELATED PROTEIN from Deinococcus radiodurans (401 aa), FASTA scores: opt: 484,E(): 2.7e-22, (32.35% identity in 399 aa overlap); Q9A766|CC1860 AMINOTRANSFERASE CLASS V from Caulobacter crescentus (408 aa), FASTA scores: opt: 390, E(): 1.5e-16,(27.85% identity in 413 aa overlap); etc.	Q7TVP3	No	intermediary metabolism and respiration							IPR000192,IPR011340,IPR015421,IPR015422,IPR015424	Q7TVP3	A0A1R3Y5J0				Rv3778c		Rv3778c			
NC_002945.3	Mycobrowser_v4	CDS	4079392	4080093	.	+	0	Mb3725	Mb3725		conserved protein	Mb3725, -, len: 233 aa. Equivalent to Rv3699, len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins e.g. Q9P3V6|SPAC1348.04 (alias Q9P3E7|SPAC750.03c or Q9P7U5|SPAC977.03) from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 188, E(): 7.5e-05, (31.65% identity in 120 aa overlap); and Q9KB70|BH2058 from Bacillus halodurans (241 aa) FASTA scores: opt: 185, E(): 0.00018, (27.8% identity in 162 aa overlap); Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 166, E(): 0.0025, (29.95% identity in 147 aa overlap); etc. Also highly similar to O06426|Rv0560c|MTCY25D10.39c HYPOTHETICAL 25.9 KDA PROTEIN from Mycobacterium tuberculosis (241 aa), FASTA scores: opt: 690, E(): 6.5e-36, (53.4% identity in 234 aa overlap); and similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c (212 aa) FASTA scores: opt: 378, E(): 1.5e-16, (35.4% identity in 192 aa overlap); P71972|Rv2675c|MTCY441.44c (250 aa) FASTA scores: opt: 297, E(): 2e-11, (31.1% identity in 193 aa overlap); etc.	Q7TVW6	No	conserved hypotheticals							IPR008854	Q7TVW6	A0A1R3Y4Y6				Rv3699		Rv3699			
NC_002945.3	Mycobrowser_v4	CDS	4161280	4163280	.	+	0	Mb3808	Mb3808		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ALANINE AND LEUCINE RICH	Mb3808, -, len: 666 aa. Equivalent to Rv3779, len: 666 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 666 aa overlap). Probable conserved transmembrane ala-, leu-rich protein, equivalent to Q9CD98|ML0116 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (654 aa), FASTA scores: opt: 1991, E(): 2e-112,(66.5% identity in 666 aa overlap). Shows some similarity with Q9RRU0|DR2395 PUTATIVE NA+/H+ ANTIPORTER from Deinococcus radiodurans (458 aa), FASTA scores: opt: 138,E(): 0.69, (31.9% identity in 138 aa overlap).	Q7TVP2	No	cell wall and cell processes								Q7TVP2	A0A1R3Y597				Rv3779		Rv3779			
NC_002945.3	Mycobrowser_v4	CDS	4080096	4081268	.	-	0	Mb3726c	Mb3726c		CONSERVED HYPOTHETICAL PROTEIN	Mb3726c, -, len: 390 aa. Equivalent to Rv3700c,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Conserved hypothetical protein; could be a transferase (EC 2.-.-.-) or a lyase (EC 4.-.-.-). Indeed, similar to various enzymes e.g. Q53824|CAC CAPREOMYCIN ACETYLTRANSFERASE from Streptomyces capreolus (359 aa), FASTA scores: opt: 338,E(): 1.1e-12, (33.35% identity in 363 aa overlap); Q9HXX3|CSD_PSEAE|PA3667 PROBABLE CYSTEINE DESULFURASE (EC 4.4.1.-) from Pseudomonas aeruginosa (401 aa) FASTA scores: opt: 260, E(): 4.8e-08, (30.2% identity in 404 aa overlap); Q9X815|SC6G10.30 PUTATIVE AMINOTRANSFERASE from Streptomyces coelicolor (460 aa), FASTA scores: opt: 243,E(): 5.4e-07, (29.15% identity in 374 aa overlap); Q9A761|CC1865 AMINOTRANSFERASE CLASS V from Caulobacter crescentus (379 aa), FASTA scores: opt: 234, E(): 1.6e-06,(27.95% identity in 383 aa overlap); O74351|NFS1_SCHPO|SPBC21D10.11c PROBABLE CYSTEINE DESULFURASE from Schizosaccharomyces pombe (Fission yeast) (498 aa), FASTA scores: opt: 232, E(): 2.5e-06, (29.1% identity in 285 aa overlap); Q9RME8|NIFS NIFS PROTEIN (CYSTEINE DESULFURASE, TRNA SPLICING PROTEIN) from Zymomonas mobilis (370 aa), FASTA scores: opt: 230, E(): 2.6e-06, (32.85% identity in 201 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.	Q7TVW5	No	intermediary metabolism and respiration							IPR000192,IPR015421,IPR015422,IPR015424,IPR027563	Q7TVW5	A0A1R3Y6I0				Rv3700c		Rv3700c			
NC_002945.3	Mycobrowser_v4	CDS	4081299	4082264	.	-	0	Mb3727c	Mb3727c		CONSERVED HYPOTHETICAL PROTEIN	Mb3727c, -, len: 321 aa. Equivalent to Rv3701c,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 321 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9RCZ8|SCM1.46 from Streptomyces coelicolor (251 aa), FASTA scores: opt: 897, E(): 1.1e-50, (59.9% identity in 242 aa overlap); P73759|SLR0865 from Synechocystis sp. strain PCC 6803 (337 aa), FASTA scores: opt: 779, E(): 5.7e-43, (40.35% identity in 327 aa overlap); Q9GWA1|LM12.997 from Leishmania major (383 aa) FASTA scores: opt: 616, E(): 2.1e-32, (39.05% identity in 297 aa overlap); etc.	Q7TVW4	No	conserved hypotheticals							IPR017804,IPR019257	Q7TVW4	A0A1R3Y5C8				Rv3701c		Rv3701c			
NC_002945.3	Mycobrowser_v4	CDS	4082261	4082962	.	-	0	Mb3728c	Mb3728c		CONSERVED HYPOTHETICAL PROTEIN	Mb3728c, -, len: 233 aa. Equivalent to Rv3702c,len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins Q9RCZ9|SCM1.45 from Streptomyces coelicolor (271 aa), FASTA scores: opt: 383, E(): 2.3e-17, (44.85% identity in 252 aa overlap); and P54004|Y199_SYNY3|SLR0199 from Synechocystis sp. strain PCC 6803 (304 aa), FASTA scores: opt: 292, E(): 1.7e-11, (30.05% identity in 263 aa overlap); and similar to others e.g. Q9KMU4|VCA0225 from Vibrio cholerae (254 aa), FASTA scores: opt: 260, E(): 1.6e-09, (29.8% identity in 245 aa overlap). Equivalent to AAK48172 from Mycobacterium tuberculosis strain CDC1551 (194 aa) but longer 39 aa.	Q7TVW3	No	conserved hypotheticals							IPR017808,IPR017932	Q7TVW3	A0A1R3Y4X8				Rv3702c		Rv3702c			
NC_002945.3	Mycobrowser_v4	CDS	4085666	4086310	.	-	0	Mb3731c	Mb3731c		conserved protein	Mb3731c, -, len: 214 aa. Equivalent to Rv3705c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Conserved hypothetical protein, equivalent to Q9CB80|ML2320 HYPOTHETICAL PROTEIN from Mycobacterium leprae (215 aa) FASTA scores: opt: 1145, E(): 5.9e-68, (79.45% identity in 214 aa overlap). Some similarity to the C-terminal end of Q11053|PKNH_MYCTU|Rv1266c|MT1304|MTCY50.16 PROBABLE SERINE/THREONINE-PROTEIN from Mycobacterium tuberculosis (626 aa), FASTA scores: opt: 175, E(): 0.0005, (24.9% identity in 201 aa overlap); and to the N-terminal end of P23903|E13B_BACCI|GLCA GLUCAN ENDO-1,3-BETA-GLUCOSIDASE A1 PRECURSOR from Bacillus circulans (682 aa), FASTA scores: opt: 122, E(): 1.6, (25.6% identity in 164 aa overlap).	Q7TVW0	No	conserved hypotheticals							IPR026954	Q7TVW0	A0A1R3Y4W8				Rv3705c		Rv3705c			
NC_002945.3	Mycobrowser_v4	CDS	4086439	4086828	.	-	0	Mb3732c	Mb3732c		CONSERVED HYPOTHETICAL PROLINE RICH PROTEIN	Mb3732c, -, len: 129 aa. Equivalent to Rv3705A,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, similar to downstream ORF O69674|Rv3706c|MTV025.054c CONSERVED HYPOTHETICAL PROLINE RICH PROTEIN from Mycobacterium tuberculosis (106 aa),FASTA scores: opt: 245, E(): 0.00013, (40.7% identity in 113 aa overlap).	Q7TVV9	No	conserved hypotheticals								Q7TVV9	A0A1R3Y4Z0				Rv3705A		Rv3705A			
NC_002945.3	Mycobrowser_v4	CDS	4087378	4088388	.	-	0	Mb3734c	Mb3734c		CONSERVED HYPOTHETICAL PROTEIN	Mb3734c, -, len: 336 aa. Equivalent to Rv3707c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Equivalent to Q9CB79|ML2321 HYPOTHETICAL PROTEIN from Mycobacterium leprae (336 aa), FASTA scores: opt: 1948, E(): 6.7e-110,(81.95% identity in 332 aa overlap); and P41402|YASD_MYCSM HYPOTHETICAL 35.9 KDA PROTEIN IN THE ASPARTOKINASE GENE CLUSTER from Mycobacterium smegmatis (333 aa), FASTA scores: opt: 1731, E(): 7.4e-97, (70.85% identity in 333 aa overlap).	Q7TVV7	No	conserved hypotheticals							IPR025442	Q7TVV7	A0A1R3Y4Z1				Rv3707c		Rv3707c			
NC_002945.3	Mycobrowser_v4	CDS	4121472	4121972	.	-	0	Mb3760c	Mb3760c		CONSERVED HYPOTHETICAL PROTEIN	Mb3760c, -, len: 166 aa. Equivalent to Rv3733c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, highly similar to Q9FCB0|2SCG58.03 PUTATIVE MUTT-LIKE PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 541, E(): 7.2e-29, (52.7% identity in 148 aa overlap); and BAB49143|MLR1881 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (156 aa), FASTA scores: opt: 526, E(): 7.2e-28,(52.65% identity in 150 aa overlap).	Q7TVT7	No	conserved hypotheticals							IPR000086,IPR015797,IPR020084	Q7TVT7	A0A1R3Y548				Rv3733c		Rv3733c			
NC_002945.3	Mycobrowser_v4	CDS	4101196	4102458	.	+	0	Mb3747	Mb3747		POSSIBLE FATTY ACID SYNTHASE	Mb3747, -, len: 420 aa. Equivalent to Rv3720, len: 420 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 420 aa overlap). Possible fatty-acyl-phospholipid synthase (EC 2.1.1.-), equivalent to Q9CB74|ML2334 (alias O69515|MLCB2407.16c, 439 aa) HYPOTHETICAL PROTEIN from Mycobacterium leprae (420 aa) FASTA scores: opt: 2508, E(): 4.7e-153, (86.45% identity in 420 aa overlap). Also similar (especially at the C-terminus) to various fatty-acid synthases (principally cyclopropane-fatty-acyl-phospholipid synthases (EC 2.1.1.79)) and hypothetical proteins e.g. Q9KZ58|SCE25.32c PUTATIVE FATTY ACID SYNTHASE from Streptomyces coelicolor (438 aa), FASTA scores: opt: 1101, E(): 5.5e-63, (46.1% identity in 425 aa overlap); P31049|YLP3_PSEPU HYPOTHETICAL 44.7 KDA PROTEIN from Pseudomonas putida (394 aa), FASTA scores: opt: 810, E(): 2.1e-44, (46.4% identity in 293 aa overlap); Q9HT28|PA5546 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (394 aa), FASTA scores: opt: 804, E(): 5.2e-44, (40.7% identity in 371 aa overlap); Q9RSD7|DR2187 PUTATIVE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Deinococcus radiodurans (462 aa), FASTA scores: opt: 747,E(): 2.6e-40, (35.95% identity in 409 aa overlap); BAB50831|Q98ET6|MLL4091 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Rhizobium loti (Mesorhizobium loti) (422 aa), FASTA scores: opt: 674, E(): 1.1e-35, (39.1% identity in 284 aa overlap); P30010|CFA_ECOLI|CDFA|B1661 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIP SYNTHASE from Escherichia coli strain K12 (381 aa), FASTA scores: opt: 530, E(): 1.7e-26, (33.65% identity in 312 aa overlap); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa); P96911|Rv0621|MTCY20H10 (354 aa); O50416|LPQD|Rv3390|MTV004.48 (236 aa); etc.	Q7TVU8	No	lipid metabolism							IPR003333	Q7TVU8	A0A1R3Y5D8				Rv3720		Rv3720			
NC_002945.3	Mycobrowser_v4	CDS	4098508	4099233	.	+	0	Mb3744	Mb3744		CONSERVED HYPOTHETICAL PROTEIN	Mb3744, -, len: 241 aa. Equivalent to Rv3717, len: 241 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 241 aa overlap). Conserved hypothetical protein, equivalent to O69518|MLCB2407.19c (alias Q9CB75|ML2331 256 aa) HYPOTHETICAL 25.1 KDA PROTEIN from Mycobacterium leprae (244 aa), FASTA scores: opt: 1325, E(): 5.7e-74, (81.95% identity in 244 aa overlap). Also similar to Q9KXK7|SCC53.04 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 536, E(): 1.2e-25, (41.2% identity in 233 aa overlap); and shows similarity with C-terminal end of other proteins e.g. Q9RMZ0|PXO2-42 PXO2-42 PROTEIN from Bacillus anthracis (531 aa), FASTA scores: opt: 191, E(): 0.00022,(26.6% identity in 222 aa overlap); Q9RTX0 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE (603 aa); Q9LCR4|CWLU CWLU PROTEIN from Paenibacillus polymyxa (Bacillus polymyxa) (524 aa), FASTA scores: opt: 141, E(): 0.24,(29.2% identity in 219 aa overlap); etc. Shows similarity with C-terminal end of O53593|CWLM|Rv3915|MTV028.06 PUTATIVE HYDROLASE from Mycobacterium tuberculosis (406 aa), FASTA scores: opt: 176, E(): 0.0014, (25.7% identity in 218 aa overlap).	Q7TVV1	No	conserved hypotheticals							IPR002508	Q7TVV1	A0A1R3Y4Z8				Rv3717		Rv3717			
NC_002945.3	Mycobrowser_v4	CDS	4094441	4095682	.	+	0	Mb3739	Mb3739		POSSIBLE LIGASE	Mb3739, -, len: 413 aa. Equivalent to Rv3712, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 413 aa overlap). Possible ligase (EC 6.-.-.-), equivalent to O69522|ML2326|MLCB2407.24c HYPOTHETICAL 43.8 KDA PROTEIN (POSSIBLE LIGASE) from Mycobacterium leprae (411 aa), FASTA scores: opt: 2265,E(): 8e-129, (84.25% identity in 413 aa overlap). Also similar to ligases or hypothetical proteins e.g. Q9FCA1|2SCG58.12 PUTATIVE LIGASE from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1168, E(): 6.7e-63, (45.8% identity in 406 aa overlap); P74303|SLR0938 HYPOTHETICAL 50.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (459 aa), FASTA scores: opt: 392, E(): 3.1e-16, (28.45% identity in 397 aa overlap); Q99ZX1|SPY1035 PUTATIVE UDP-N-ACETYLMURAMYL TRIPEPTIDE SYNTHETASE (EC 6.3.2.13) from Streptococcus pyogenes (445 aa), FASTA scores: opt: 335, E(): 8.1e-13,(29.2% identity in 438 aa overlap); Q9CGJ0|YLBD HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (449 aa), FASTA scores: opt: 324, E(): 3.8e-12, (28.75% identity in 445 aa overlap); Q9ZGG7|MURC UDP-N-ACETYLMURAMYL TRIPEPTIDE SYNTHETASE from Heliobacillus mobilis (455 aa), FASTA scores: opt: 292, E(): 3.2e-10, (30.75% identity in 449 aa overlap); etc.	Q7TVV4	No	intermediary metabolism and respiration							IPR013221,IPR013564	Q7TVV4	A0A1R3Y514				Rv3712		Rv3712			
NC_002945.3	Mycobrowser_v4	CDS	4132180	4132392	.	-	0	Mb3771c	Mb3771c		CONSERVED HYPOTHETICAL PROTEIN	Mb3771c, -, len: 70 aa. Equivalent to Rv3745c, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 70 aa overlap). Conserved hypothetical protein, highly similar to others e.g. N-terminus of Q9X4E6 HYPOTHETICAL 13.4 KDA PROTEIN from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (124 aa), FASTA scores: opt: 279, E(): 4.4e-14, (59.4% identity in 69 aa overlap); N-terminus of Q9A2A6|CC3660 HYPOTHETICAL PROTEIN from Caulobacter crescentus (172 aa) FASTA scores: opt: 272, E(): 1.9e-13, (63.35% identity in 60 aa overlap); N-terminus of P74345|SLR1628 HYPOTHETICAL 14.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (134 aa), FASTA scores: opt: 233, E(): 1.3e-10, (54.85% identity in 62 aa overlap); etc.	Q7TVS8	No	conserved hypotheticals							IPR018714	Q7TVS8	A0A1R3Y523				Rv3745c		Rv3745c			
NC_002945.3	Mycobrowser_v4	CDS	4096391	4097281	.	-	0	Mb3741c	Mb3741c		CONSERVED HYPOTHETICAL PROTEIN	Mb3741c, -, len: 296 aa. Equivalent to Rv3714c,len: 296 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 296 aa overlap). Conserved hypothetical protein, highly similar to O07396|MAV346 MAV346 PROTEIN from Mycobacterium avium (346 aa) FASTA scores: opt: 834, E(): 2.2e-46, (50.0% identity in 286 aa overlap); and also highly similar to several proteins from Mycobacterium tuberculosis e.g. O53421|Rv1073|MTV017.26 (283 aa), FASTA scores: opt: 869, E(): 1e-48, (51.1% identity in 270 aa overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FASTA scores: opt: 775, E(): 1.3e-42, (46.35% identity in 289 aa overlap); P96837|Rv3555c|MTCY06G11.02c (289 aa), FASTA scores: opt: 733, E(): 5.9e-40, (44.15% identity in 281 aa overlap); etc. Partially similar to Q9Z512|UVRC_STRCO|SCC54.13c EXCINUCLEASE ABC SUBUNIT C from Streptomyces coelicolor (728 aa), FASTA scores: opt: 122, E(): 2.5, (27.0% identity in 174 aa overlap). Equivalent to AAK48186 from Mycobacterium tuberculosis strain CDC1551 (341 aa) but shorter 45 aa.	Q7TVV2	No	conserved hypotheticals							IPR011335,IPR025159	Q7TVV2	A0A1R3Y4Y1				Rv3714c		Rv3714c			
NC_002945.3	Mycobrowser_v4	CDS	4099766	4101178	.	+	0	Mb3746	Mb3746		conserved protein	Mb3746, -, len: 470 aa. Equivalent to Rv3719, len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 470 aa overlap). Conserved hypothetical protein, equivalent to O69516|ML2333|MLCB2407.17c HYPOTHETICAL 51.8 KDA PROTEIN from Mycobacterium leprae (459 aa), FASTA scores: opt: 2593, E(): 7.8e-161, (82.75% identity in 458 aa overlap). Also some similarity to Q9CU63|5830417J06RIK HYPOTHETICAL PROTEIN (FRAGMENT) from Mus musculus (Mouse) (479 aa) FASTA scores: opt: 454, E(): 6.1e-22, (27.1% identity in 413 aa overlap); Q9HBA8 SELADIN-1 (UNKNOWN) from Homo sapiens (Human) (516 aa),FASTA scores: opt: 444, E(): 2.9e-21, (26.7% identity in 412 aa overlap); O17397|DIMH_CAEEL|F52H2.6 DIMINUTO-LIKE PROTEIN from Caenorhabditis elegans (525 aa), FASTA scores: opt: 419, E(): 1.2e-19, (24.4% identity in 434 aa overlap); Q39085|DIM_ARATH|DWF1 CELL ELONGATION PROTEIN DIMINUTO from Arabidopsis thaliana (Mouse-ear cress) (561 aa) FASTA scores: opt: 318, E(): 4.8e-13, (24.6% identity in 455 aa overlap); etc. Also some similarity to M. tuberculosis hypothetical proteins P72056|Rv3790|MTCY13D12.24 (461 aa) FASTA scores: opt: 174, E(): 0.00016; (25.1% identity in 426 aa overlap); and Q50685|Rv2280|MTCY339_30c (459 aa).	Q7TVU9	No	conserved hypotheticals							IPR006094,IPR016164,IPR016166,IPR016169	Q7TVU9	A0A1R3Y6K4				Rv3719		Rv3719			
NC_002945.3	Mycobrowser_v4	CDS	4108881	4110074	.	+	0	Mb3753	Mb3753		possible dehydrogenase	Mb3753, -, len: 397 aa. Equivalent to Rv3726, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 397 aa overlap). Possible dehydrogenase (EC 1.-.-.-), similar to many e.g. O34788|YDJL DEHYDROGENASE from Bacillus subtilis (346 aa) FASTA scores: opt: 401, E(): 3.4e-17, (29.6% identity in 395 aa overlap); Q59696|ADH 2,3-BUTANEDIOL DEHYDROGENASE (EC 1.1.1.4) from seudomonas putida (362 aa), FASTA scores: opt: 326, E(): 1.3e-12, (29.45% identity in 387 aa overlap); AAG59541|YJJN PUTATIVE OXIDOREDUCTASE from Escherichia coli strain EDL933 (345 aa), FASTA scores: opt: 325, E(): 1.5e-12, (30.85% identity in 256 aa overlap); Q9HWM8|PA4153 2,3-BUTANEDIOL DEHYDROGENASE from Pseudomonas aeruginosa (363 aa), FASTA scores: opt: 324,E(): 1.8e-12, (30.5% identity in 387 aa overlap); etc.	Q7TVU3	No	intermediary metabolism and respiration							IPR002085,IPR011032,IPR013149,IPR013154,IPR016040	Q7TVU3	A0A1R3Y528				Rv3726		Rv3726			
NC_002945.3	Mycobrowser_v4	CDS	4104281	4105588	.	-	0	Mb3749c	Mb3749c		conserved protein	Mb3749c, -, len: 435 aa. Equivalent to Rv3722c,len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 435 aa overlap). Conserved hypothetical protein, equivalent to O69513|MLCB2407.14 (alias Q9CB73|ML2336, 463 aa) HYPOTHETICAL 46.8 KDA PROTEIN from Mycobacterium leprae (426 aa), FASTA scores: opt: 2505, E(): 8.3e-154, (87.25% identity in 424 aa overlap). Also highly similar to Q9RU17|DR1579 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (452 aa), FASTA scores: opt: 1162, E(): 3.1e-67, (44.8% identity in 422 aa overlap); and partially similar to Q9I371|PA1654 PROBABLE AMINOTRANSFERASE from Pseudomonas aeruginosa (388 aa) FASTA scores: opt: 162, E(): 0.0078,(25.85% identity in 348 aa overlap) and other aminotransferases. N-terminus extended since first submission (previously 408 aa).	Q7TVU7	No	conserved hypotheticals							IPR015422,IPR015424,IPR024551	Q7TVU7	A0A1R3Y516				Rv3722c		Rv3722c			
NC_002945.3	Mycobrowser_v4	CDS	4105996	4106760	.	+	0	Mb3750	Mb3750		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3750, -, len: 254 aa. Equivalent to Rv3723, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Probable conserved transmembrane protein, with hydrophobic stretches at the N-terminus, and equivalent to O69512|ML2337|MLCB2407.13c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (250 aa), FASTA scores: opt: 1029, E(): 1.2e-44, (64.45% identity in 253 aa overlap).	Q7TVU6	No	cell wall and cell processes								Q7TVU6	A0A1R3Y537				Rv3723		Rv3723			
NC_002945.3	Mycobrowser_v4	CDS	4107673	4108674	.	+	0	Mb3752	Mb3752		possible oxidoreductase	Mb3752, -, len: 333 aa. Equivalent to Rv3725, len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Possible reductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa), FASTA scores: opt: 317, E(): 6.1e-11, (30.5% identity in 272 aa overlap); Q9SZB3|F17M5.120|AT4G33360|AAK49584 HYPOTHETICAL 37.9 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (344 aa), FASTA scores: opt: 314, E(): 9.1e-11, (30.35% identity in 267 aa overlap); AAK59445|AT4G33360 PUTATIVE DIHYDROKAEMPFEROL 4-REDUCTASE from Arabidopsis thaliana (Mouse-ear cress) (332 aa), FASTA scores: opt: 313, E(): 1e-10, (30.8% identity in 263 aa overlap); Q9FSC6|CCR CINNAMOYL-COA REDUCTASE (EC 1.2.1.44) from Populus trichocarpa (Western balsam poplar) (338 aa), FASTA scores: opt: 305, E(): 2.9e-10, (30.3% identity in 274 aa overlap); Q9M631 CINNAMOYL CoA REDUCTASE from Populus tremuloides (Quaking aspen) (337 aa), FASTA scores: opt: 291, E(): 1.8e-09, (30.15% identity in 272 aa overlap); P73212|DFRA_SYNY3|LR1706 PUTATIVE DIHYDROFLAVONOL-4-REDUCTASE (EC 1.1.1.219) (DIHYDROKAEMPFEROL 4-REDUCTASE) from Synechocystis sp. strain PCC 6803 (343 aa), FASTA scores: opt: 278, E(): 1e-08, (29.35% identity in 259 aa overlap); etc. Also some similarity to proteins from Mycobacterium tuberculosis e.g. P96816|Rv0139|MTCI5.13 HYPOTHETICAL PROTEIN (340 aa) FASTA scores: opt: 234, E(): 3.2e-06, (28.25% identity in 269 aa overlap); and O06373|galE1|Rv3634c|MTCY15C10.18 PROBABLE UDP-GLUCOSE 4-EPIMERASE (314 aa) (27.3% identity in 194 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-a) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa).	Q7TVU4	No	intermediary metabolism and respiration							IPR001509,IPR016040	Q7TVU4	A0A1R3Y527				Rv3725		Rv3725			
NC_002945.3	Mycobrowser_v4	CDS	2687782	2688828	.	+	0	Mb2446	Mb2446		HYPOTHETICAL PROTEIN	Mb2446, -, len: 348 aa. Equivalent to Rv2423, len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 348 aa overlap). Hypothetical unknown protein.	Q7TYL9	No	conserved hypotheticals								Q7TYL9	A0A1R3Y166				Rv2423		Rv2423			
NC_002945.3	Mycobrowser_v4	CDS	4110415	4112223	.	+	0	Mb3754	Mb3754		POSSIBLE OXIDOREDUCTASE	Mb3754, -, len: 602 aa. Equivalent to Rv3727, len: 602 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 602 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to several plants phytoene dehydrogenases/desaturases (EC 1.3.-.-) e.g. Q9HSE1|CRTI3|VNG0277G PHYTOENE DEHYDROGENASE from Halobacterium sp. strain NRC-1 (541 aa), FASTA scores: opt: 299, E(): 1.1e-10, (29.85% identity in 576 aa overlap); Q9FZL6|CITPDS1 PHYTOENE DESATURASE from Citrus unshiu (Satsuma orange) (553 aa), FASTA scores: opt: 164,E(): 0.018, (24.2% identity in 434 aa overlap); Q07356|CRTI_ARATH|PDS|AT4G14210|DL3145c PHYTOENE DEHYDROGENASE PRECURSOR from Arabidopsis thaliana (Mouse-ear cress) (566 aa), FASTA scores: opt: 163, E(): 0.021, (23.95% identity in 434 aa overlap); etc. N-terminal end similar to O69871|SC1C3.29 PUTATIVE PROTOPORPHYRINOGEN OXIDASE (FRAGMENT) from Streptomyces coelicolor (61 aa), FASTA scores: opt: 154, E(): 0.012,(60.45% identity in 43 aa overlap). The region between aa 155-310 is highly similar to Q49778|B2126_C1_169 from Mycobacterium leprae (159 aa), FASTA scores: opt: 437,E(): 1.5e-19, (46.6% identity in 161 aa overlap). And the region between aa 462-546 is highly similar to the N-terminal end of Q50003|U1764T from Mycobacterium leprae (155 aa), FASTA scores: opt: 277, E(): 8.3e-10, (57.65% identity in 85 aa overlap).	Q7TVU2	No	intermediary metabolism and respiration								Q7TVU2	A0A1R3Y506				Rv3727		Rv3727			
NC_002945.3	Mycobrowser_v4	CDS	4112333	4115530	.	+	0	Mb3755	Mb3755		PROBABLE CONSERVED TWO-DOMAIN MEMBRANE PROTEIN	Mb3755, -, len: 1065 aa. Equivalent to Rv3728, len: 1065 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1065 aa overlap). Probable conserved transmembrane protein organised into two domains. Domain comprising the first ~510 aa residues is similar to various multidrug resistance and efflux proteins and contains sugar transport protein signature 1 (PS00216). Domain corresponding to the last 550 aa residues contains cyclic nucleotide-binding domain signature 2 (PS00889) and is very similar to Q50733|YP65_MYCTU|Rv2565|MT2641|MTCY9C4.03c hypothetical 62.1 kDa protein from Mycobacterium tuberculosis (31.0% identity in 546 aa overlap). Highly similar to O05884|Rv3239c|MTCY20B11.14c PROBABLE TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis (1048 aa) FASTA scores: opt: 4328, E(): 5e-201, (64.15% identity in 1046 aa overlap). N-terminal end similar to P71879|Rv2333c|MTCY3G12.01|MTCY98.02c (537 aa); P71836|Rv0783c|MTCY369.27c (540 aa); and O07753|Rv1877|MTCY180.41c (687 aa). SEEMS BELONG TO THE SUGAR TRANSPORTER FAMILY. Possibly member of major facilitator superfamily (MFS).	Q7TVU1	No	cell wall and cell processes							IPR000595,IPR001411,IPR002641,IPR004638,IPR005829,IPR011701,IPR014710,IPR016035,IPR016196,IPR018488,IPR018490,IPR020846	Q7TVU1	A0A1R3Y515				Rv3728		Rv3728			
NC_002945.3	Mycobrowser_v4	CDS	4115745	4118075	.	+	0	Mb3756	Mb3756		POSSIBLE TRANSFERASE	Mb3756, -, len: 776 aa. Equivalent to Rv3729, len: 776 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 776 aa overlap). Conserved hypothetical protein, possible transferase (EC 2.-.-.-), similar to several hypothetical proteins and various transferases e.g. O26919|MTH831 MOLYBDENUM COFACTOR BIOSYNTHESIS MOAA HOMOLOG from Methanobacterium thermoautotrophicum (497 aa), FASTA scores: opt: 697, E(): 4.8e-34, (30.7% identity in 492 aa overlap); Q58036|Y619_METJA|MJ0619 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (506 aa), FASTA scores: opt: 670, E(): 2e-32, (30.6% identity in 497 aa overlap); O27968|AF2316 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (518 aa), FASTA scores: opt: 477, E(): 6.4e-21, (29.4% identity in 500 aa overlap); BAB60102|TVG0985801 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Thermoplasma volcanium (606 aa), FASTA scores: opt: 402, E(): 2.1e-16, (28.1% identity in 509 aa overlap); etc. C-terminus similar to methyltransferases e.g. Q9S0N6|AVED C5-O-METHYLTRANSFERASE from Streptomyces avermitilis (283 aa), FASTA scores: opt: 298, E(): 1.9e-10, (31.5% identity in 292 aa overlap). Also similar to the Mycobacterium tuberculosis proteins P71673|YE05_MYCTU|Rv1405c|MT1449|MTCY21B4.22c (274 aa); and Q50584|Rv1523|MTCY19G5.05c.	Q7TVU0	No	intermediary metabolism and respiration							IPR007197,IPR013216,IPR013785	Q7TVU0	A0A1R3Y6L4				Rv3729		Rv3729			
NC_002945.3	Mycobrowser_v4	CDS	4118140	4119180	.	-	0	Mb3757c	Mb3757c		CONSERVED HYPOTHETICAL PROTEIN	Mb3757c, -, len: 346 aa. Equivalent to Rv3730c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Conserved hypothetical protein, highly similar to Q9XAM1|SC4C6.19 HYPOTHETICAL 38.5 KDA PROTEIN from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1313, E(): 2.2e-75, (59.25% identity in 336 aa overlap); and similar to C-terminal end of PUTATIVE ATP-DEPENDENT DNA LIGASES e.g. BAB49297|MLL2077 from Rhizobium loti (Mesorhizobium loti) (833 aa), FASTA scores: opt: 550, E(): 5.3e-27, (31.3% identity in 294 aa overlap); and BAB54816|MLL9625 from Rhizobium loti (Mesorhizobium loti) plasmid pMLb (883 aa) FASTA scores: opt: 492, E(): 2.5e-23, (33.7% identity in 291 aa overlap); etc. Also similar to the hypothetical proteins e.g. Q9ZC15|SC1E6.07 HYPOTHETICAL 34.9 KDA PROTEIN from Streptomyces coelicolor (319 aa) FASTA scores: opt: 537, E(): 1.5e-26, (34.95% identity in 292 aa overlap); Q9XAF7|SC6G9.25 HYPOTHETICAL 32.1 KDA PROTEIN from Streptomyces coelicolor (293 aa), FASTA scores: opt: 474, E(): 1.3e-22, (33.75% identity in 302 aa overlap); etc. Also highly similar to P95226|Rv0269c|MTCY06A4.13c HYPOTHETICAL 44.0 KDA PROTEIN from Mycobacterium tuberculosis (397 aa), FASTA scores: opt: 940, E(): 7.7e-52, (50.3% identity in 312 aa overlap).	Q7TVT9	No	conserved hypotheticals							IPR002755,IPR014145	Q7TVT9	A0A1R3Y5E6				Rv3730c		Rv3730c			
NC_002945.3	Mycobrowser_v4	CDS	4134500	4134892	.	-	0	Mb3776c	Mb3776c		possible excisionase	Mb3776c, -, len: 130 aa. Equivalent to Rv3750c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Possible excisionase,similar to others e.g. Q9LCU5 PUTATIVE EXCISIONASE from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 297, E(): 1.2e-12, (40.35% identity in 114 aa overlap); O85865 PUTATIVE EXCISIONASE from Sphingomonas aromaticivorans plasmid pNL1 (152 aa), FASTA scores: opt: 223, E(): 7.3e-08, (39.15% identity in 97 aa overlap); Q9XBH1|XIS EXCISIONASE from Bacteroides fragilis (124 aa) FASTA scores: opt: 128, E(): 0.1, (30.7% identity in 88 aa overlap); etc. Also some similarity to transcriptional regulators. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c (114 aa) FASTA scores: opt: 224, E(): 4.9e-08, (42.7% identity in 82 aa overlap). Contains helix-turn-helix motif at aa 55-76 (Score 1925,+5.74 SD).	Q7TVS3	No	insertion seqs and phages							IPR009061,IPR010093	Q7TVS3	A0A1R3Y6N1				Rv3750c		Rv3750c			
NC_002945.3	Mycobrowser_v4	CDS	4124094	4125155	.	+	0	Mb3763	Mb3763		TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARAC/XYLS-FAMILY)	Mb3763, -, len: 353 aa. Equivalent to Rv3736, len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 353 aa overlap). Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 HYPOTHETICAL 35.4 KDA PROTEIN from Bradyrhizobium japonicum (318 aa), FASTA scores: opt: 438,E(): 2e-20, (29.4% identity in 306 aa overlap); Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 395,E(): 1.1e-17, (30.3% identity in 320 aa overlap); Q9HTN1|PA5324 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (356 aa), FASTA scores: opt: 313,E(): 1.8e-12, (25.85% identity in 329 aa overlap); Q9Z3Y6|PHBR TRANSCRIPTIONAL REGULATOR PHBR from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 271,E(): 8.3e-10, (22.95% identity in 357 aa overlap); etc. Also highly similar to Q06861|VIRS_MYCTU|Rv3082c|MTV013.03c POSSIBLE VIRULENCE-REGULATING PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 656, E(): 3.7e-34, (36.95% identity in 333 aa overlap); and similar to other hypothetical mycobacterial proteins e.g. P71663|YD95_MYCTU|Rv1395|MT1440|MTCY21B4.12 (344 aa). Contains helix-turn-helix motif at aa 245-266 (Score 1140,+3.07 SD). SEEMS BELONG TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TVT5	No	regulatory proteins							IPR009057,IPR018060	Q7TVT5	A0A1R3Y533				Rv3736		Rv3736			
NC_002945.3	Mycobrowser_v4	CDS	4125159	4126748	.	+	0	Mb3764	Mb3764		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3764, -, len: 529 aa. Equivalent to Rv3737, len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 529 aa overlap). Probable conserved transmembrane protein, similar to others and also some hypothetical proteins e.g. AAK61331|THRE THREONINE EXPORT CARRIER from Corynebacterium glutamicum (Brevibacterium flavum) (489 aa), FASTA scores: opt: 773, E(): 1.8e-36,(37.25% identity in 424 aa overlap); Q9X8J0|SCE9.17 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (578 aa), FASTA scores: opt: 642, E(): 5.4e-29, (31.6% identity in 481 aa overlap) (shorter 119 aa at N-terminus); Q9CJU6|PM1895 HYPOTHETICAL PROTEIN from Pasteurella multocida (262 aa), FASTA scores: opt: 233,E(): 4.1e-06, (25.0% identity in 256 aa overlap); Q9S267|SCI30A.06 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (297 aa), FASTA scores: opt: 163,E(): 0.042, (29.65% identity in 263 aa overlap); etc. Also partially similar to O05435|Rv3910|MTCY15F10.01c|MTV028.01 HYPOTHETICAL 123.6 KDA PROTEIN from Mycobacterium tuberculosis (1184 aa) (34.4% identity in 125 aa overlap).	Q7TVT4	No	cell wall and cell processes							IPR010619,IPR024528	Q7TVT4	A0A1R3Y517				Rv3737		Rv3737			
NC_002945.3	Mycobrowser_v4	CDS	4127127	4128473	.	-	0	Mb3766c	Mb3766c		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb3766c, -, len: 448 aa. Equivalent to Rv3740c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 448 aa overlap). Conserved hypothetical protein, highly similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa) FASTA scores: opt: 1917, E(): 2.3e-112, (61.4% identity in 451 aa overlap); Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 858, E(): 3.4e-46, (37.4% identity in 460 aa overlap); Q10554|Y895_MYCTU|Rv0895|MT0919|MTCY31.23 (505 aa), FASTA scores: opt: 767, E(): 1.9e-40, (44.3% identity in 467 aa overlap); MTCY31_25; MTCY28_26; MTCY493_29; MTCY21B4_43; MTCY8D5_16; MTCY3A2_28; MTV013_8; MTY13E12_33; MTV013_9; MTY20B11_9; etc. Also similar to Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 319,E(): 1.7e-12, (30.9% identity in 453 aa overlap).	Q7TVT3	No	lipid metabolism							IPR004255,IPR009721,IPR014292	Q7TVT3	A0A1R3Y6M1				Rv3740c		Rv3740c			
NC_002945.3	Mycobrowser_v4	CDS	4135168	4135383	.	+	0	Mb3777	Mb3777		probable integrase (fragment)	Mb3777, -, len: 71 aa. Equivalent to Rv3751, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Probable integrase (fragment), similar to part of many e.g. Q48908 INTEGRASE (FRAGMENT) from Mycobacterium paratuberculosis (191 aa),FASTA scores: opt: 206, E(): 5.5e-08, (57.65% identity in 59 aa overlap); Q9ZWV7|INT INTEGRASE from Corynephage 304L (395 aa), FASTA scores: opt: 156, E(): 0.00036, (45.75% identity in 59 aa overlap); Q9K722|BH3551 INTEGRASE (PHAGE-RELATED PROTEIN) from Bacillus halodurans (378 aa),FASTA scores: opt: 151, E(): 0.00079, (46.15% identity in 52 aa overlap); etc. Also similarity with various conjugative transposons. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71903|Rv2309c|MTCY3G12.25 (151 aa), FASTA scores: opt: 193, E(): 3.8e-07, (50.85% identity in 59 aa overlap); O53403|Rv1055|MTV017.08 (78 aa), FASTA scores: opt: 171,E(): 7.8e-06, (54.15% identity in 48 aa overlap); etc.	Q7TVS2	No	insertion seqs and phages							IPR002104,IPR011010,IPR013762	Q7TVS2	A0A1R3Y5G1				Rv3751		Rv3751			
NC_002945.3	Mycobrowser_v4	CDS	4136015	4136536	.	-	0	Mb3779c	Mb3779c		conserved protein	Mb3779c, -, len: 173 aa. Equivalent to Rv3753c,len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Conserved hypothetical protein, only equivalent to Q9CB33|ML2473 HYPOTHETICAL PROTEIN from Mycobacterium leprae (159 aa) FASTA scores: opt: 920 E(): 1.4e-52,, (88.6% identity in 158 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv (173 aa versus 166 aa).	Q7TVS0	No	conserved hypotheticals							IPR023869	Q7TVS0	A0A1R3Y545				Rv3753c		Rv3753c			
NC_002945.3	Mycobrowser_v4	CDS	4128473	4129147	.	-	0	Mb3767c	Mb3767c		POSSIBLE OXIDOREDUCTASE	Mb3767c, -, len: 224 aa. Equivalent to Rv3741c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible oxidoreductase, probably combines with product of upstream ORF MTV025.090c to form a functional monooxygenase (EC 1.-.-.-), highly similar to C-terminal end of various oxidoreductases e.g. Q9APW3 AROMATIC-RING HYROXYLASE from Pseudomonas aeruginosa (508 aa), FASTA scores: opt: 549,E(): 5.9e-28, (56.1% identity in 155 aa overlap); Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 487,E(): 5.6e-24, (39.55% identity in 225 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 460, E(): 4.7e-22, (38.5% identity in 226 aa overlap); etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN (489 aa), FASTA scores: opt: 542, E(): 1.6e-27, (50.0% identity in 162 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa), FASTA scores: opt: 462,E(): 2.2e-22, (37.15% identity in 226 aa overlap); O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa), FASTA scores: opt: 462, E(): 2.2e-22, (45.65% identity in 173 aa overlap); etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in upstream ORF (MTV025.090c) after a gap of ~100 aa.	Q7TVT2	No	intermediary metabolism and respiration								Q7TVT2	A0A1R3Y5F4				Rv3741c		Rv3741c			
NC_002945.3	Mycobrowser_v4	CDS	4129144	4129539	.	-	0	Mb3768c	Mb3768c		POSSIBLE OXIDOREDUCTASE	Mb3768c, -, len: 131 aa. Equivalent to Rv3742c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Possible oxidoreductase, probably combines with product of downstream ORF MTV025.090c to form a functional monooxygenase (EC 1.-.-.-), highly similar to N-terminal end of various oxidoreductases e.g. Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 170, E(): 0.00048,(47.55% identity in 103 aa overlap); Q9APW3 AROMATIC-RING HYROXYLASE from Pseudomonas aeruginosa (508 aa) FASTA scores: opt: 160, E(): 0.0022, (50.55% identity in 87 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 153,E(): 0.0097, (45.45% identity in 88 aa overlap); etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN (489 aa), FASTA scores: opt: 140, E(): 0.044, (37.1% identity in 132 aa overlap); O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa) FASTA scores: opt: 133, E(): 0.13,(43.05% identity in 79 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa),FASTA scores: opt: 110, E(): 4.1, (42.85% identity in 77 aa overlap); etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in downstream ORF (MTV025.089c) after a gap of ~100 aa.	Q7TVT1	No	intermediary metabolism and respiration								Q7TVT1	A0A1R3Y538				Rv3742c		Rv3742c			
NC_002945.3	Mycobrowser_v4	CDS	4133923	4134432	.	-	0	Mb3775c	Mb3775c		CONSERVED HYPOTHETICAL PROTEIN	Mb3775c, -, len: 169 aa. Equivalent to Rv3749c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Hypothetical protein,showing some similarity with O85864 HYPOTHETICAL 21.4 KDA PROTEIN from Sphingomonas aromaticivorans plasmid pNL1 (196 aa), FASTA scores: opt: 148, E(): 0.011, (32.7% identity in 104 aa overlap); Q9LCU6 HYPOTHETICAL 21.2 KDA PROTEIN from Arthrobacter sp. TM1 (192 aa), FASTA scores: opt: 125, E(): 0.35, (31.5% identity in 92 aa overlap); Q9L631|SPCB MYO-INOSITOL-2-DEHYDROGENASE from Streptomyces spectabilis (374 aa); Q9WJP8|PRE-S1 PRE-S1 PROTEIN (FRAGMENT) from Hepatitis B virus (88 aa); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature.	Q7TVS4	No	conserved hypotheticals								Q7TVS4	A0A1R3Y529				Rv3749c		Rv3749c			
NC_002945.3	Mycobrowser_v4	CDS	4141832	4142134	.	+	0	Mb3786	Mb3786		POSSIBLE CONSERVED MEMBRANE PROTEIN	Mb3786, -, len: 100 aa. Equivalent to Rv3760, len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Possible conserved membrane protein, equivalent to Q50094|ML2366|MLCB12.11c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 423, E(): 1.2e-20, (67.7% identity in 99 aa overlap). Also similar with Q9JST1|NMA2149 PUTATIVE INNER MEMBRANE HYPOTHETICAL PROTEIN from Neisseria meningitidis (serogroup A) (104 aa), FASTA scores: opt: 113, E(): 0.95, (33.85% identity in 62 aa overlap); and showing similarity with Q9ZAX7 ABC TRANSPORTER MEMBRANE PROTEIN SUBUNIT from Streptococcus mutans (498 aa), FASTA scores: opt: 108, E(): 6.7, (42.35% identity in 85 aa overlap) (similarity at C-terminus); and P33108|SECY_MICLU PREPROTEIN TRANSLOCASE SECY SUBUNIT from Micrococcus luteus (Micrococcus lysodeikticus) (436 aa),FASTA scores: opt: 106, E(): 8.2, (29.05% identity in 86 aa overlap). Equivalent to AAK48231 from Mycobacterium tuberculosis strain CDC1551 (117 aa) but shorter 17 aa.	Q7TVR3	No	cell wall and cell processes							IPR010445	Q7TVR3	A0A1R3Y6N8				Rv3760		Rv3760			
NC_002945.3	Mycobrowser_v4	CDS	4135541	4135999	.	-	0	Mb3778c	Mb3778c		POSSIBLE CYTIDINE/DEOXYCYTIDYLATE DEAMINASE	Mb3778c, -, len: 152 aa. Equivalent to Rv3752c,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Probable cytidine/deoxycytidylate deaminase (EC 3.5.4.-),equivalent to Q9CB32|ML2474 POSSIBLE CYTIDINE/DEOXYCYTIDYLATE DEAMINASE from Mycobacterium leprae (171 aa), FASTA scores: opt: 890, E(): 1.6e-50,(88.1% identity in 151 aa overlap). Also highly similar to other deaminases and hypothetical proteins e.g. Q9AK79|2SCD60.04c PUTATIVE DEAMINASE from Streptomyces coelicolor (143 aa), FASTA scores: opt: 559, E(): 2.9e-29,(66.45% identity in 146 aa overlap); Q9F9W7 CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa) FASTA scores: opt: 512, E(): 3.1e-26, (54.85% identity in 144 aa overlap); P21335|YAAJ_BACSU HYPOTHETICAL 17.8 KDA PROTEIN from Bacillus subtilis (161 aa), FASTA scores: opt: 425,E(): 1.4e-20, (47.7% identity in 151 aa overlap); AAK74212|SP0020 CYTIDINE/DEOXYCYTIDYLATE DEAMINASE FAMILY PROTEIN from Streptococcus pneumoniae (155 aa), FASTA scores: opt: 401, E(): 4.7e-19, (46.25% identity in 147 aa overlap); P30134|YFHC_ECOLI|B2559 HYPOTHETICAL 20.0 KDA PROTEIN from Escherichia coli strain K12 (178 aa), FASTA scores: opt: 397, E(): 9.5e-19, (47.0% identity in 149 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY.	Q7TVS1	No	intermediary metabolism and respiration							IPR002125,IPR016192,IPR016193,IPR028883	Q7TVS1	A0A1R3Y550				Rv3752c		Rv3752c			
NC_002945.3	Mycobrowser_v4	CDS	4149290	4150234	.	-	0	Mb3793c	Mb3793c		possible s-adenosylmethionine-dependent methyltransferase	Mb3793c, -, len: 314 aa. Equivalent to Rv3767c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96823|Rv0146|MTCI5.20 HYPOTHETICAL 34.0 KDA PROTEIN (310 aa), FASTA scores: opt: 909, E(): 5.3e-50, (48.1% identity in 316 aa overlap); O53686|Rv0281|MTV035.09 (302 aa),FASTA scores: opt: 802, E(): 2.8e-43, (45.2% identity in 314 aa overlap); Q50726|YX99_MYCTU|Rv3399|MT3507|MTCY78.29c (348 aa), FASTA scores: opt: 796, E(): 7.6e-43, (45.35% identity in 302 aa overlap); MTCY78_30; MTCY31_23; MTCY210_45; MTCY4C12_14; MTY13D12_21, MTCI5_19; MTCY180_22; etc. Contains probable N-terminal signal sequence	X2BPS7,Q7TVQ7	No	lipid metabolism								X2BPS7,Q7TVQ7	Q7TVQ7				Rv3767c		Rv3767c			
NC_002945.3	Mycobrowser_v4	CDS	4137583	4138182	.	-	0	Mb3781c	Mb3781c		conserved protein	Mb3781c, -, len: 199 aa. Equivalent to Rv3755c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Conserved hypothetical protein showing similarity to CAC47343|SMC03980 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (196 aa) FASTA scores: opt: 244, E(): 4.1e-09, (30.9% identity in 191 aa overlap); Q9I2B5|PA1994 from Pseudomonas aeruginosa (187 aa), FASTA scores: opt: 226, E(): 6e-08, (29.9% identity in 194 aa overlap); and Q98N73|MLR0268 HYPOTHETICAL PROTEIN (183 aa), FASTA scores: opt: 234, E(): 1.8e-08,(27.05% identity in 185 aa overlap).	Q7TVR8	No	conserved hypotheticals							IPR009467	Q7TVR8	A0A1R3Y540				Rv3755c		Rv3755c			
NC_002945.3	Mycobrowser_v4	CDS	4150909	4151181	.	+	0	Mb3795	Mb3795		HYPOTHETICAL PROTEIN	Mb3795, -, len: 90 aa. Equivalent to Rv3769, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein, possible coiled-coil protein.	Q7TVQ5	No	conserved hypotheticals								Q7TVQ5	A0A1R3Y558				Rv3769		Rv3769			
NC_002945.3	Mycobrowser_v4	CDS	4154884	4155120	.	-	0	Mb3802c	Mb3802c		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb3802c, -, len: 78 aa. Equivalent to 5' end of Rv3773c, len: 194 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 52 aa overlap). Hypothetical protein, highly similar to C-terminal end of O53773|Rv0576|MTV039.14 POSSIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 575, E(): 8.3e-30, (47.4% identity in 192 aa overlap); and some similarity with other proteins from M. tuberculosis e.g. P71985|Rv1727|MTCY04C12.12 (189 aa) FASTA scores: opt: 176, E(): 0.00022, (31.1% identity in 180 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv3773c into 2 parts,Mb3801c and Mb3802c.	Q7TVP8	No									Q7TVP8	A0A1R3Y571									
NC_002945.3	Mycobrowser_v4	CDS	4152698	4153024	.	-	0	Mb3799c	Mb3799c		CONSERVED HYPOTHETICAL PROTEIN	Mb3799c, -, len: 108 aa. Equivalent to Rv3771c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Hypothetical protein,highly similar, but shorter 81 aa, to P71640|Rv2811|MTCY16B7.32c HYPOTHETICAL 21.1 KDA PROTEIN from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 469, E(): 2.7e-25, (73.15% identity in 108 aa overlap)	Q7TVQ1	No	conserved hypotheticals								Q7TVQ1	A0A1R3Y575				Rv3771c		Rv3771c			
NC_002945.3	Mycobrowser_v4	CDS	4143290	4145170	.	-	0	Mb3788c	Mb3788c		possible hydrolase	Mb3788c, -, len: 626 aa. Equivalent to Rv3762c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 626 aa overlap). Possible hydrolase (EC 3.-.-.-), highly similar to hypothetical proteins and beta-lactamases (EC 3.5.2.6) e.g. Q9RL04|SC5G9.23 HYPOTHETICAL 70.3 KDA PROTEIN from Streptomyces coelicolor (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083 HYPOTHETICAL 73.2 KDA PROTEIN from Escherichia coli strain K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113,(46.9% identity in 631 aa overlap); Q9A824|CC1540 METALLO-BETA-LACTAMASE FAMILY PROTEIN from Caulobacter crescentus (647 aa), FASTA scores: opt: 1891, E(): 1e-111,(48.55% identity in 628 aa overlap); Q08347|YOL164W CHROMOSOME XV READING FRAME ORF from Saccharomyces cerevisiae (Baker's yeast) (646 aa) FASTA scores: opt: 1829, E(): 8.4e-108, (45.7% identity in 615 aa overlap); Q9I5I9|PA0740 PROBABLE BETA-LACTAMASE from Pseudomonas aeruginosa (658 aa), FASTA scores: opt: 1699, E(): 1.4e-99, (43.15% identity in 630 aa overlap); Q52556|SDSA ALKYL SULFATASE (protein involved in the degradation of sulfate esters of long-chain primaryal cohols e.g. SDS sodium dodecyl sulfate) from Pseudomonas sp (528 aa),FASTA scores: opt: 841, E(): 1.7e-45, (33.7% identity in 534 aa overlap); etc. N-terminual end also highly similar to Q48790|SEPA SEPA PROTEIN (protein implicated in cell separation) from Listeria monocytogenes (391 aa), FASTA scores: opt: 1256, E(): 8.3e-72, (49.6% identity in 363 aa overlap). Also slight similarity to P96253|Rv0407|MTCY22G10.03 HYPOTHETICAL 37.0 KDA PROTEIN from Mycobacterium tuberculosis (336 aa).	Q7TVR1	No	intermediary metabolism and respiration							IPR001279,IPR003033	Q7TVR1	A0A1R3Y554				Rv3762c		Rv3762c			
NC_002945.3	Mycobrowser_v4	CDS	4148587	4149276	.	+	0	Mb3792	Mb3792		HYPOTHETICAL PROTEIN	Mb3792, -, len: 229 aa. Equivalent to Rv3766, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Hypothetical unknown protein. Segment 183 to 229 highly similar to C-terminal part of O06288|Rv3594|MTCY07H7B.28c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 128, E(): 0.92, (46.8% identity in 47 aa overlap).	Q7TVQ8	No	conserved hypotheticals							IPR017853	Q7TVQ8	A0A1R3Y559				Rv3766		Rv3766			
NC_002945.3	Mycobrowser_v4	CDS	3303419	3304279	.	-	0	Mb3014c	Mb3014c		HYPOTHETICAL PROTEIN	Mb3014c, -, len: 286 aa. Equivalent to Rv2990c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Hypothetical unknown protein.	Q7TXH4,A0A1R3Y369	No	conserved hypotheticals			A0A1R3Y369					Q7TXH4					Rv2990c		Rv2990c			
NC_002945.3	Mycobrowser_v4	CDS	4154535	4154879	.	-	0	Mb3801c	Mb3801c		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb3801c, -, len: 114 aa. Equivalent to 3' end of Rv3773c, len: 194 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 114 aa overlap). Hypothetical protein, highly similar to C-terminal end of O53773|Rv0576|MTV039.14 POSSIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 575, E(): 8.3e-30, (47.4% identity in 192 aa overlap); and some similarity with other proteins from Mycobacterium tuberculosis e.g. P71985|Rv1727|MTCY04C12.12 (189 aa) FASTA scores: opt: 176, E(): 0.00022, (31.1% identity in 180 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv3773c in two parts, Mb3802c and Mb3801c.	Q7TVP9	No								IPR017517,IPR017520	Q7TVP9	A0A1R3Y567									
NC_002945.3	Mycobrowser_v4	CDS	4199628	4200638	.	-	0	Mb3832c	Mb3832c		probable conserved membrane protein	Mb3832c, -, len: 336 aa. Equivalent to Rv3802c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Conserved hypothetical protein, equivalent to Q9CDB3|ML0099 HYPOTHETICAL PROTEIN from Mycobacterium leprae (336 aa) FASTA scores: opt: 1759, E(): 1.1e-85, (75.5% identity in 335 aa overlap). Contains probable N-terminal signal sequence followed by Pro-rich region.	Q7TVM8	No	cell wall and cell processes							IPR000675	Q7TVM8					Rv3802c		Rv3802c			
NC_002945.3	Mycobrowser_v4	CDS	4157384	4158943	.	+	0	Mb3805	Mb3805		CONSERVED HYPOTHETICAL PROTEIN	Mb3805, -, len: 519 aa. Equivalent to Rv3776, len: 519 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 519 aa overlap). Hypothetical protein,highly similar to Q10709|YL00_MYCTU|Rv2100|MTCY49.40 HYPOTHETICAL 58.9 KDA PROTEIN from Mycobacterium tuberculosis (550 aa) FASTA scores: opt: 1646, E(): 1.2e-83, (77.85% identity in 510 aa overlap) (homology from potential start at 7744); and similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O33266|Rv0336|MTCY279.03 (503 aa) FASTA scores: opt: 682, E(): 2.2e-30, (41.65% identity in 497 aa overlap).	Q7TVP5	No	conserved hypotheticals							IPR003615,IPR003870	Q7TVP5	A0A1R3Y565				Rv3776		Rv3776			
NC_002945.3	Mycobrowser_v4	CDS	4158989	4159975	.	+	0	Mb3806	Mb3806		probable oxidoreductase	Mb3806, -, len: 328 aa. Equivalent to Rv3777, len: 328 aa, from Mycobacterium tuberculosis strain H7Rv,(99.7% identity in 328 aa overlap). Probable oxidoreductase (EC 1.-.-.-), equivalent to Q9CD96|ML0118 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (336 aa) FASTA scores: opt: 1661, E(): 1.1e-87, (76.0% identity in 325 aa overlap). Also highly similar to many e.g. Q9XA55|SCGD3.24c PUTATIVE QUINONE OXIDOREDUCTASE (EC 1.6.5.5) from Streptomyces coelicolor (326 aa) FASTA scores: opt: 1118, E(): 1.3e-64, (59.6% identity in 312 aa overlap); O65423|F18E5.200|F17L22.40|AT4G21580 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Arabidopsis thaliana (Mouse-ear cress) (325 aa), FASTA scores: opt: 1110, E(): 3e-56, (52.15% identity in 326 aa overlap); Q98FI0|MLL3767 NADPH QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 980,E(): 7.9e-49, (47.85% identity in 324 aa overlap); etc.	Q7TVP4	No	intermediary metabolism and respiration							IPR002085,IPR011032,IPR013149,IPR013154,IPR014189,IPR016040	Q7TVP4	A0A1R3Y6Q7				Rv3777		Rv3777			
NC_002945.3	Mycobrowser_v4	CDS	4338393	4339127	.	-	0	Mb3947c	Mb3947c		CONSERVED HYPOTHETICAL PROTEIN	Mb3947c, -, len: 244 aa. Equivalent to Rv3916c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 244 aa overlap). Conserved hypothetical protein, equivalent to Q50200|ML2705|L222-ORF1 HYPOTHETICAL PROTEIN from Mycobacterium leprae (259 aa), FASTA scores: opt: 1266,E(): 2e-74, (76.4% identity in 250 aa overlap). Also highly similar (but with gaps) to Q9R3S2|STH24.10 HYPOTHETICAL 22.6 KDA PROTEIN from Streptomyces coelicolor (205 aa), FASTA scores: opt: 387, E(): 7.5e-18, (40.25% identity in 231 aa overlap).	Q7TVC6	No	conserved hypotheticals								Q7TVC6	A0A1R3Y5M7				Rv3916c		Rv3916c			
NC_002945.3	Mycobrowser_v4	CDS	4163284	4163820	.	+	0	Mb3809	Mb3809		conserved protein	Mb3809, -, len: 178 aa. Equivalent to Rv3780, len: 178 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 178 aa overlap). Conserved hypothetical protein, equivalent to Q9CD99|ML0115 HYPOTHETICAL 19.1 KDA PROTEIN from Mycobacterium leprae (174 aa), FASTA scores: opt: 903, E(): 2.3e-48, (82.95% identity in 170 aa overlap). Also highly similar to Q9XA56|SCGD3.23c HYPOTHETICAL 19.5 KDA PROTEIN from Streptomyces coelicolor (179 aa), FASTA scores: opt: 692,E(): 1.8e-35, (65.9% identity in 170 aa overlap). Note that this putative protein is 4 aa longer at the N-terminus compared to previous annotation (in Nature 393: 537-544 (1998)).	X2BQ23	No	conserved hypotheticals								X2BQ23	P65092				Rv3780		Rv3780			
NC_002945.3	Mycobrowser_v4	CDS	4169905	4170831	.	-	0	Mb3816c	Mb3816c		CONSERVED HYPOTHETICAL PROTEIN	Mb3816c, -, len: 308 aa. Equivalent to Rv3787c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Conserved hypothetical protein, highly similar to several mycobacterial hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c from Mycobacterium tuberculosis (367 aa), FASTA scores: opt: 1038, E(): 1.6e-58, (55.85% identity in 283 aa overlap); O53795|MBE50c|Rv0731c|MTV041.05c from Mycobacterium tuberculosis (318 aa), FASTA scores: opt: 1030,E()|Rv0731c|MTV041.05c from Mycobacterium tuberculosis (318 aa), FASTA scores: opt: 1030, E(): 4.5e-58, (56.15% identity in 292 aa overlap); Q9CCZ4|ML2640 from Mycobacterium leprae (310 aa) FASTA scores: opt: 709, E(): 9.9e-38, (43.75% identity in 279 aa overlap).	X2BPK3,Q7TVN7	No	conserved hypotheticals								X2BPK3,Q7TVN7	Q7TVN7				Rv3787c		Rv3787c			
NC_002945.3	Mycobrowser_v4	CDS	4215503	4216288	.	-	0	Mb3844c	Mb3844c		possible acyltransferase	Mb3844c, -, len: 261 aa. Equivalent to Rv3814c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Possible acyltransferase (EC 2.3.1.-), highly similar to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa), FASTA scores: opt: 753, E(): 7.7e-42,(46.75% identity in 246 aa overlap). Also highly similar to many acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 587, E(): 4.6e-31,(41.95% identity in 243 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 293, E(): 6.6e-12, (29.2% identity in 267 aa overlap); Q9PNZ5|AAS|CJ0938 PUTATIVE 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE / ACYL-ACYL CARRIER PROTEIN SYNTHETASE from Campylobacter jejuni (1170 aa), FASTA scores: opt: 274, E(): 3.9e-10,(29.1% identity in 219 aa overlap) (similarity only with middle section); Q9EY25 PUTATIVE ACETYL TRANSFERASE from Xanthomonas oryzae pv. oryzae (249 aa), FASTA scores: opt: 238, E(): 2.4e-08, (29.2% identity in 209 aa overlap); etc. Also highly similar to downstream ORFs O07808|Rv3815c|MTCY409.15 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (251 aa), FASTA scores: opt: 1069, E(): 2.1e-62, (60.4% identity in 245 aa overlap); and O07807|Rv3816c|MTCY409.14 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (259 aa), FASTA scores: opt: 776, E(): 2.5e-43, (50.9% identity in 228 aa overlap). And similar to O53516|Rv2182c|MTV021.15c HYPOTHETICAL 27.0 KDA PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 239, E(): 2e-08,(30.6% identity in 232 aa overlap).	Q7TVL9	No	intermediary metabolism and respiration							IPR002123	Q7TVL9	A0A1R3Y5D0				Rv3814c		Rv3814c			
NC_002945.3	Mycobrowser_v4	CDS	4167615	4168688	.	+	0	Mb3814	Mb3814		HYPOTHETICAL PROTEIN	Mb3814, -, len: 357 aa. Equivalent to Rv3785, len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). Hypothetical unknown protein. Note that this putative protein is equivalent to AAK48258|MT3893 NAD-DEPENDENT EPIMERASE/DEHYDRATASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (712 aa), but shorter 355 aa.	X2BQ24	No	conserved hypotheticals								X2BQ24	P65094				Rv3785		Rv3785			
NC_002945.3	Mycobrowser_v4	CDS	4168669	4169892	.	-	0	Mb3815c	Mb3815c		unknown protein	Mb3815c, -, len: 407 aa. Equivalent to Rv3786c,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 407 aa overlap). Hypothetical unknown protein. Segment between aa 265-300 (approximatively) is highly similar to part of O03937|RORF1608 MINOR CAPSID PROTEIN from Bacteriophage phig1e (1608 aa), FASTA scores: opt: 242, E(): 8.4e-07, (26.85% identity in 272 aa overlap); Q9ETT9|ORF36 PUTATIVE PEPTIDASE from Corynebacterium equii (Rhodococcus equi) plasmid pREAT701 (p33701) and Plasmid virulence (546 aa), FASTA scores: opt: 231, E(): 1.6e-06, (34.15% identity in 167 aa overlap); O69910|SC2E1.40c HYPOTHETICAL 22.8 KDA PROTEIN. from Streptomyces coelicolor (226 aa) FASTA scores: opt: 218, E(): 4.6e-06, (34.15% identity in 164 aa overlap); and others.	X2BP78	No	conserved hypotheticals								X2BP78	P0A5H2				Rv3786c		Rv3786c			
NC_002945.3	Mycobrowser_v4	CDS	4171075	4171560	.	+	0	Mb3817	Mb3817		HYPOTHETICAL PROTEIN	Mb3817, -, len: 161 aa. Equivalent to Rv3788, len: 161 aa, from Mycobacetrium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Hypothetical unknown protein.	X2BPE5,P65096	No	conserved hypotheticals								X2BPE5,P65096	P65096				Rv3788		Rv3788			
NC_002945.3	Mycobrowser_v4	CDS	4247283	4247981	.	-	0	Mb3867c	Mb3867c		PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) (PHOSPHOGLYCERATE PHOSPHOMUTASE)	Mb3867c, -, len: 232 aa. Equivalent to Rv3837c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 232 aa overlap). Probable phosphoglycerate mutase (EC 5.4.2.-), equivalent to Q9CDC3|ML0079 PUTATIVE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (231 aa), FASTA scores: opt: 1116,E(): 7.3e-66, (71.55% identity in 232 aa overlap). Also similar to others e.g. Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 474, E(): 6.4e-24, (41.85% identity in 203 aa overlap); Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa) FASTA scores: opt: 349, E(): 1e-15, (33.2% identity in 223 aa overlap); Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 256, E(): 1.2e-09, (34.0% identity in 203 aa overlap); Q9RVD2|DR1097 PUTATIVE PHOSPHOGLYCERATE MUTASE from Deinococcus radiodurans (232 aa), FASTA scores: opt: 201, E(): 5.1e-06, (31.45% identity in 175 aa overlap); etc. Also similar to P71724|Rv2419c|MTCY428.28|MTCY253.01 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium tuberculosis (223 aa), FASTA scores: opt: 210, E(): 1.3e-06, (32.0% identity in 172 aa overlap). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature.	Q7TVJ7	No	intermediary metabolism and respiration							IPR013078	Q7TVJ7	A0A1R3Y5N0				Rv3837c		Rv3837c			
NC_002945.3	Mycobrowser_v4	CDS	4245320	4246669	.	+	0	Mb3865	Mb3865		conserved membrane protein	Mb3865, -, len: 449 aa. Equivalent to Rv3835, len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable conserved membrane protein, equivalent to Q9CDC2|ML0081 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (450 aa), FASTA scores: opt: 2079, E(): 1.8e-74, (69.35% identity in 457 aa overlap).	Q7TVJ9	No	cell wall and cell processes							IPR026004	Q7TVJ9	A0A1R3Y5E8				Rv3835		Rv3835			
NC_002945.3	Mycobrowser_v4	CDS	4242509	4243084	.	-	0	Mb3862c	Mb3862c		conserved protein	Mb3862c, -, len: 191 aa. Equivalent to Rv3832c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 191 aa overlap). Conserved hypothetical protein, similar in part to various proteins e.g. Q9XBC9|CZA382.22c PUTATIVE RRNA METHYLASE from Amycolatopsis orientalis (259 aa), FASTA scores: opt: 196,E(): 1.3e-05, (38.2% identity in 110 aa overlap); CAC48459|SMB20059 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (259 aa), FASTA scores: opt: 188, E(): 4.3e-05, (33.8% identity in 136 aa overlap); Q98FP8|MLL3672 METHYL TRANSFERASE-LIKE PROTEIN from Rhizobium loti (Mesorhizobium loti) (264 aa), FASTA scores: opt: 180,E(): 0.00014, (32.05% identity in 156 aa overlap); etc.	Q7TVK1	No	conserved hypotheticals							IPR013216	Q7TVK1					Rv3832c		Rv3832c			
NC_002945.3	Mycobrowser_v4	CDS	4189288	4189905	.	+	0	Mb3827	Mb3827		PUTATIVE TRANSPOSASE [FIRST PART]	Mb3827, -, len: 205 aa. Equivalent to 5' end of Rv3798, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 195 aa overlap). Putative transposase for insertion sequence element IS1557, highly similar to Q60255 SIMILAR TO TRANSPOSASE OF ISAE1 FROM ALCALIGENES EUTROPHUS H1-4 (FRAGMENT) from dibenzofuran-degrading bacterium DPO360 (163 aa) FASTA scores: opt: 767, E(): 3.2e-42, (67.25% identity in 168 aa overlap); and similar to P74920 TRANSPOSASE from Thiobacillus ferrooxidans (404 aa), FASTA scores: opt: 375, E(): 1.1e-16, (27.55% identity in 439 aa overlap); Q48349 TRANSPOSASE from Alcaligenes eutrophus (Ralstonia eutropha) (408 aa), FASTA scores: opt: 324, E(): 2e-13,(3.9% identity in 369 aa overlap); Q9FDC1|TNP TRANSPOSASE from Burkholderia mallei (Pseudomonas mallei) (386 aa) FASTA scores: opt: 282, E(): 9.8e-11, (25.85% identity in 391 aa overlap); etc. C-terminal end identical to O53804|Rv0741|MTV041.15 TRANSPOSASE from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 582, E(): 1.8e-30, (85.6% identity in 104 aa overlap). BELONGS TO THE TRANSPOSASE FAMILY 12. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3798 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828.	Q7TTK1	No								IPR002560	Q7TTK1										
NC_002945.3	Mycobrowser_v4	CDS	4189880	4190611	.	+	0	Mb3828	Mb3828		PUTATIVE TRANSPOSASE [SECOND PART]	Mb3828, -, len: 243 aa. Equivalent to 3' end of Rv3798, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 243 aa overlap). Putative transposase for insertion sequence element IS1557, highly similar to Q60255 SIMILAR TO TRANSPOSASE OF ISAE1 FROM ALCALIGENES EUTROPHUS H1-4 (FRAGMENT) from dibenzofuran-degrading bacterium DPO360 (163 aa) FASTA scores: opt: 767, E(): 3.2e-42, (67.25% identity in 168 aa overlap); and similar to P74920 TRANSPOSASE from Thiobacillus ferrooxidans (404 aa), FASTA scores: opt: 375, E(): 1.1e-16, (27.55% identity in 439 aa overlap); Q48349 TRANSPOSASE from Alcaligenes eutrophus (Ralstonia eutropha) (408 aa), FASTA scores: opt: 324, E(): 2e-13,(3.9% identity in 369 aa overlap); Q9FDC1|TNP TRANSPOSASE from Burkholderia mallei (Pseudomonas mallei) (386 aa) FASTA scores: opt: 282, E(): 9.8e-11, (25.85% identity in 391 aa overlap); etc. C-terminal end identical to O53804|Rv0741|MTV041.15 TRANSPOSASE from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 582, E(): 1.8e-30, (85.6% identity in 104 aa overlap). BELONGS TO THE TRANSPOSASE FAMILY 12. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv3798 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828.	Q7TTF3	No								IPR002560	Q7TTF3										
NC_002945.3	Mycobrowser_v4	CDS	4216306	4217061	.	-	0	Mb3845c	Mb3845c		possible acyltransferase	Mb3845c, -, len: 251 aa. Equivalent to Rv3815c,len: 251 a, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Possible acyltransferase (EC 2.3.1.-), highly similar to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa), FASTA scores: opt: 845, E(): 2.7e-47,(53.25% identity in 246 aa overlap). Also highly similar to Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 656,E(): 3.7e-35, (47.85% identity in 234 aa overlap); and similar to many putative acyltransferases and hypothetical proteins e.g. P74498|SLL1848 HYPOTHETICAL 24.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (225 aa) FASTA scores: opt: 275, E(): 1.2e-10, (34.8% identity in 181 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 266,E(): 5.2e-10, (29.7% identity in 229 aa overlap); Q9PNZ5|AAS|CJ0938 PUTATIVE 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE/ ACYL-ACYL CARRIER PROTEIN SYNTHETASE from Campylobacter jejuni (1170 aa), FASTA scores: opt: 264, E(): 2.3e-09,(23.55% identity in 221 aa overlap) (similarity only with middle section); etc. Also highly similar to upstream ORF O07809|Rv3814c|MTCY409.16 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 1069, E(): 1e-61, (60.4% identity in 245 aa overlap) ; and downstream ORF O07807|Rv3816c|MTCY409.14 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (259 aa) FASTA scores: opt: 847, E(): 2e-47, (55.7% identity in 246 aa overlap). And similar to O53516|Rv2182c|MTV021.15c HYPOTHETICAL 27.0 KDA PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 237, E(): 3.6e-08, (30.9% identity in 233 aa overlap).	Q7TVL8	No	intermediary metabolism and respiration							IPR002123	Q7TVL8					Rv3815c		Rv3815c			
NC_002945.3	Mycobrowser_v4	CDS	4206113	4206610	.	-	0	Mb3837c	Mb3837c		POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3837c, -, len: 165 aa. Equivalent to Rv3807c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Possible conserved transmembrane protein, equivalent to Q9CDB6|ML0094 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (192 aa), FASTA scores: opt: 714, E(): 2.4e-38, (72.85% identity in 151 aa overlap). Also highly similar to Q9KZA3|SC5G8.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 324,E(): 1.1e-13, (41.5% identity in 159 aa overlap); and similar in part to others e.g. Q9K3L3|SCG20A.27 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (230 aa), FASTA scores: opt: 277, E(): 1.3e-10, (41.65% identity in 168 aa overlap); P72269|ORF8 HYPOTHETICAL PROTEIN from Rhodococcus erythropolis (487 aa) FASTA scores: opt: 229, E(): 2.7e-07, (36.25% identity in 149 aa overlap); O86625|SC3A7.24c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (201 aa) FASTA scores: opt: 200, E(): 9.1e-06, (34.95% identity in 146 aa overlap); Q9KYD7|SCD72A.19 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (238 aa) FASTA scores: opt: 178, E(): 0.00026, (35.7% identity in 112 aa overlap); etc.	Q7TVM5	No	cell wall and cell processes							IPR000326	Q7TVM5					Rv3807c		Rv3807c			
NC_002945.3	Mycobrowser_v4	CDS	4222246	4222959	.	+	0	Mb3851	Mb3851		PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN	Mb3851, -, len: 237 aa. Equivalent to Rv3821, len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 237 aa overlap). Probable conserved integral membrane protein, equivalent to Q49630|ML1233|B1170_F2_64 HYPOTHETICAL 24.4 KDA PROTEIN /INTEGRAL MEMBRANE PROTEIN (POTENTIAL) from Mycobacterium leprae (230 aa), FASTA scores: opt: 619, E(): 2.4e-32,(46.65% identity in 240 aa overlap). Shows some similarity to P29466|I1BC_HUMAN|CASP1|IL1BC|IL1BCE (404 aa), FASTA scores: opt: 126, E(): 0.88, (29.05% identity in 155 aa overlap). Also highly similar to P71796|Rv1517|MTCY277.39 HYPOTHETICAL 26.9 KDA PROTEIN from Mycobacterium tuberculosis (254 aa), FASTA scores: opt: 284, E(): 5.4e-11, (36.35% identity in 256 aa overlap). Start site chosen on basis of similarity to LEPB1170_F2_64 and MTCY277.39, but may extend further upstream.	Q7TVL2	No	cell wall and cell processes							IPR021315	Q7TVL2					Rv3821		Rv3821			
NC_002945.3	Mycobrowser_v4	CDS	4211071	4212690	.	+	0	Mb3841	Mb3841		CONSERVED HYPOTHETICAL PROTEIN	Mb3841, -, len: 539 aa. Equivalent to Rv3811, len: 539 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 539 aa overlap). Conserved hypothetical protein, showing some similarity to Q9KZK5|SCE34.21c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 603,E(): 8.1e-26, (34.4% identity in 404 aa overlap); Q9S2P9|SC5F7.14c HYPOTHETICAL 31.9 KDA PROTEIN from Streptomyces coelicolor (308 aa), FASTA scores: opt: 472,E(): 9.5e-19, (37.5% identity in 208 aa overlap). Middle section (approximatively aa 185-350/390) shows some similarity with Q9GK12 PEPTIDOGLYCAN RECOGNITION PROTEIN PRECURSOR from Camelus dromedarius (Dromedary) (Arabian camel) (193 aa) FASTA scores: opt: 274, E(): 4.6e-08,(32.2% identity in 177 aa overlap); O75594|PGLYRP|PGRP from Homo sapiens (Human) (196 aa), FASTA scores: opt: 272, E(): 6e-08, (30.9% identity in 220 aa overlap); Q9JLN4|PGRP PEPTIDOGLYCAN RECOGNITION PROTEIN from Rattus norvegicus (Rat) (182 aa), FASTA scores: opt: 253, E(): 6.2e-07, (32.15% identity in 171 aa overlap); etc. C-terminal end shows similarity with Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (ONE OF THE TWO MAJOR SECRETED PROTEINS) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa), FASTA scores: opt: 250, E(): 2.7e-06, (39.45% identity in 109 aa overlap). Contains PS00687 Aldehydedehydrogenases glutamic acid active site. Note that previously known as csp.	Q7TVM2	No	conserved hypotheticals							IPR002502,IPR006619,IPR013207,IPR015510	Q7TVM2					Rv3811		Rv3811			
NC_002945.3	Mycobrowser_v4	CDS	4214667	4215488	.	-	0	Mb3843c	Mb3843c		conserved protein	Mb3843c, -, len: 273 aa. Equivalent to Rv3813c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 273 aa overlap). Conserved hypothetical protein, equivalent to Q9CDB9|ML0089 HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa) FASTA scores: opt: 1479, E(): 9.6e-81, (80.45% identity in 271 aa overlap); and similar to Q98LI0|MLL1014 from (280 aa) . Also similar to many hypothetical proteins from several organisms e.g. Q9ZBX2|SCD78.27c from Streptomyces coelicolor (280 aa),FASTA scores: opt: 597, E(): 2.2e-28, (43.25% identity in 266 aa overlap); Q9RXR7|DR0240 from Deinococcus radiodurans (284 aa), FASTA scores: opt: 543, E(): 3.5e-25, (38.65% identity in 264 aa overlap); Q99YH5|SPY1700 from Streptococcus pyogenes (274 aa) FASTA scores: opt: 373, E(): 4.3e-15, (30.75% identity in 270 aa overlap); P70947|YITU from Bacillus subtilis (270 aa) FASTA scores: opt: 353, E(): 6.5e-14, (30.0% identity in 280 aa overlap); etc.	Q7TVM0	No	conserved hypotheticals							IPR000150,IPR006379,IPR023214	Q7TVM0					Rv3813c		Rv3813c			
NC_002945.3	Mycobrowser_v4	CDS	4260288	4260944	.	+	0	Mb3880	Mb3880		conserved protein	Mb3880, -, len: 218 aa. Equivalent to Rv3850, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Conserved hypothetical protein, equivalent to Q9CDD0|ML0068 HYPOTHETICAL PROTEIN from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071, E(): 7.2e-55, (78.35% identity in 217 aa overlap).	Q7TVI5	No	conserved hypotheticals								Q7TVI5					Rv3850		Rv3850			
NC_002945.3	Mycobrowser_v4	CDS	4217065	4217844	.	-	0	Mb3846c	Mb3846c		possible acyltransferase	Mb3846c, -, len: 259 aa. Equivalent to Rv3816c,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Possible acyltransferase (EC 2.3.1.-), equivalent to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa) FASTA scores: opt: 1401, E(): 1.5e-80, (81.9% identity in 254 aa overlap). Also highly similar to many putative acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 758, E(): 2.4e-40,(51.7% identity in 234 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 312, E(): 2e-12, (29.55% identity in 237 aa overlap); O67841|AAS|AQ_2058 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE from Aquifex aeolicus (211 aa), FASTA scores: opt: 281, E(): 1.5e-10, (32.7% identity in 162 aa overlap); etc. Also highly similar to upstream ORFs O07808|Rv3815c|MTCY409.15 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (251 aa), FASTA scores: opt: 847, E(): 6.7e-46, (55.7% identity in 246 aa overlap); and O07809|Rv3814c|MTCY409.16 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 776, E(): 1.9e-41, (50.9% identity in 228 aa overlap).	Q7TVL7	No	intermediary metabolism and respiration							IPR002123	Q7TVL7					Rv3816c		Rv3816c			
NC_002945.3	Mycobrowser_v4	CDS	4217920	4218675	.	+	0	Mb3847	Mb3847		possible phosphotransferase	Mb3847, -, len: 251 aa. Equivalent to Rv3817, len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Possible phosphotransferase (EC 2.7.-.-), similar to many phosphotransferases e.g. O53023 KANAMYCIN MARKER from Escherichia coli (264 aa), FASTA scores: opt: 232, E(): 7.5e-08, (32.4% identity in 247 aa overlap); BAA78209|NEO NEOMYCINE PHOSPHOTRANSFERASE from Drosophila melanogaster (Fruit fly) (264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0% identity in 247 aa overlap); AAG09774 AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Vibrio cholerae (264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0% identity in 247 aa overlap); P00552|KKA2_KLEPN|NEO|KAN AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Klebsiella pneumoniae (264 aa), FASTA scores: opt: 227, E(): 1.6e-07,(32.0% identity in 247 aa overlap); etc.	Q7TVL6	No	intermediary metabolism and respiration							IPR002575,IPR011009,IPR024165	Q7TVL6					Rv3817		Rv3817			
NC_002945.3	Mycobrowser_v4	CDS	4218722	4220272	.	+	0	Mb3848	Mb3848		unknown protein	Mb3848, -, len: 516 aa. Equivalent to Rv3818, len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 516 aa overlap). Hypothetical unknown protein.	Q7TVL5	No	conserved hypotheticals							IPR001279,IPR017941	Q7TVL5					Rv3818		Rv3818			
NC_002945.3	Mycobrowser_v4	CDS	4222994	4224208	.	+	0	Mb3852	Mb3852		CONSERVED HYPOTHETICAL PROTEIN	Mb3852, -, len: 404 aa. Equivalent to Rv3822, len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 404 aa overlap). Conserved hypothetical protein, similar in part to hypothetical proteins from Mycobacterium leprae: Q9CC62|ML1232 (358 aa) FASTA scores: opt: 601, E(): 1.1e-25, (36.7% identity in 335 aa overlap); and Q49633|B1170_F3_112 (391 aa) FASTA scores: opt: 601, E(): 1.2e-25, (36.25% identity in 347 aa overlap). Also similar to P71862|Rv3539|MTCY03C7.17c PPE FAMILY PROTEIN from Mycobacterium tuberculosis (479 aa),FASTA scores: opt: 547, E(): 1.3e-22, (38.1% identity in 281 aa overlap); O50440|Rv1184c|MTV005.20c (359 aa); O06828|Rv1430|MTCY493.24c (528 aa); O53642|Rv0159c|MTV032.02c (468 aa); etc.	Q7TVL1	No	conserved hypotheticals							IPR013228	Q7TVL1					Rv3822		Rv3822			
NC_002945.3	Mycobrowser_v4	CDS	4237836	4239062	.	-	0	Mb3857c	Mb3857c		possible transposase	Mb3857c, -, len: 408 aa. Equivalent to Rv3827c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 408 aa overlap). Possible transposase within IS1537 element, similar to several transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|DR1651|DR1933 TRANSPOSASE from Deinococcus radiodurans(408 aa) FASTA scores: opt: 302, E(): 3.9e-12, (30.75% identity in 358 aa overlap); Q9RXX7|DR0178 PUTATIVE TRANSPOSASE from Deinococcus radiodurans (409 aa), FASTA scores: opt: 297,E(): 8.2e-12, (31.1% identity in 360 aa overlap); P73816|SLR2062 TRANSPOSASE from Synechocystis sp. strain PCC 6803 (400 aa), FASTA scores: opt: 296, E(): 9.3e-12,(30.05% identity in 353 aa overlap); etc. Highly similar to proteins from Mycobacterium tuberculosis e.g. O33333|Rv2791c|MTV002.56c TRANSPOSASE (459 aa) FASTA scores: opt: 2211, E(): 9.4e-136, (87.75% identity in 367 aa overlap); P95117|Rv2978c|MTCY349.09 HYPOTHETICAL 51.4 KDA PROTEIN (459 aa), FASTA scores: opt: 2165, E(): 9e-133, (85.85% identity in 367 aa overlap); Q10809|YS85_MYCTU|Rv2885c|MT2953|MTCY274.16c HYPOTHETICAL 51.3 KDA PROTEIN (460 aa), FASTA scores: opt: 2127, E(): 2.6e-130, (83.95% identity in 368 aa overlap); O0777|Rv0606|MTCY19H5.16c PROBABLE TRANSPOSASE (FRAGMENT) (247 aa), FASTA scores: opt: 1405, E(): 9.3e-84, (85.3% identity in 238 aa overlap); etc.	Q7TVK6	No	insertion seqs and phages							IPR001959,IPR021027	Q7TVK6	A0A1R3Y5M6				Rv3827c		Rv3827c			
NC_002945.3	Mycobrowser_v4	CDS	4239059	4239670	.	-	0	Mb3858c	Mb3858c		POSSIBLE RESOLVASE	Mb3858c, -, len: 203 aa. Equivalent to Rv3828c, len 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Possible resolvase within IS1537 element, similar to others e.g. Q97X40|SSO1915 FIRST ORF IN TRANSPOSON ISC1913 from Sulfolobus solfataricus (213 aa), FASTA scores: opt: 275,E(): 1.6e-11, (30.6% identity in 196 aa overlap); Q9V1M0|PAB2076 RESOLVASE RELATED PROTEIN from Pyrococcus abyssi (212 aa), FASTA scores: opt: 254, E(): 4.2e-10,(29.95% identity in 197 aa overlap); Q9RMU7|ORFA PUTATIVE TRANSPOSASE (BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS) from elicobacter pylori (Campylobacter pylori) (217 aa), FASTA scores: opt: 243, E(): 2.3e-09, (31.8% identity in 154 aa overlap); etc. Also highly similar to proteins from Mycobacterium tuberculosis e.g. O33334|Rv2792c|MTV002.57c RESOLVASE (193 aa), FASTA scores: opt: 970, E(): 1.5e-58, (79.25% identity in 193 aa overlap); O07773|Rv0605|MTCY19H5.17c PUTATIVE RESOLVASE (202 aa), FASTA scores: opt: 964, E(): 4e-58, (76.25% identity in 202 aa overlap); P95116|Rv2979c|MTCY349.08 HYPOTHETICAL 21.4 KDA PROTEIN (194 aa), FASTA scores: opt: 895, E(): 1.8e-53, (74.75% identity in 194 aa overlap); Q10831|YS86_MYCTU|Rv2886c|MT2954|MTCY274.17c HYPOTHETICAL 31.9 KDA PROTEIN (295 aa), FASTA scores: opt: 826, E(): 1.1e-48, (66.2% identity in 204 aa overlap) (similarity only at C-terminus); etc. Contains PS00397 Site-specific recombinases active site. Possible helix-turn-helix motif from aa 11-32, Score 1305 (+3.63 SD).	Q7TVK5	No	insertion seqs and phages							IPR006118,IPR006119	Q7TVK5	A0A1R3Y5C9				Rv3828c		Rv3828c			
NC_002945.3	Mycobrowser_v4	CDS	4239671	4241281	.	-	0	Mb3859c	Mb3859c		probable dehydrogenase	Mb3859c, -, len: 536 aa. Equivalent to Rv3829c, len 536 aa, from Mycobacetrium tuberculosis strain H37Rv,(99.8% identity in 536 aa overlap). Probable oxidoreductase dehydrogenase (EC 1.-.-.-), similar to others e.g. Q9A3T1|CC3121 PHYTOENE DEHYDROGENASE-RELATED PROTEIN from Caulobacter crescentus (543 aa), FASTA scores: opt: 607, E(): 9.2e-28, (28.25% identity in 552 aa overlap); Q98FP6|MLR3676 PHYTOENE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (521 aa), FASTA scores: opt: 605, E(): 1.2e-27, (28.2% identity in 546 aa overlap); Q97W24|SSO2422 PHYTOENE DEHYDROGENASE RELATED PROTEIN from Sulfolobus solfataricus (518 aa), FASTA scores: opt: 388, E(): 4.4e-15, (27.35% identity in 530 aa overlap); Q98BS8|MLL5443 PROBABLE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (524 aa), FASTA scores: opt: 374, E(): 2.9e-14, (24.35% identity in aa overlap); etc. Also similar to MTCY493.22c|Rv1432|MTCY493.22c HYPOTHETICAL 50.5 KDA PROTEIN (probable dehydrogenase) from Mycobacterium tuberculosis (25.1% identity in 295 aa overlap).	Q7TVK4	No	intermediary metabolism and respiration								Q7TVK4	A0A1R3Y5D4				Rv3829c		Rv3829c			
NC_002945.3	Mycobrowser_v4	CDS	4257811	4258344	.	+	0	Mb3877	Mb3877		HYPOTHETICAL PROTEIN	Mb3877, -, len: 177 aa. Equivalent to Rv3847, len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). Conserved hypothetical protein, equivalent to Q9CDC7|ML0071 HYPOTHETICAL PROTEIN from Mycobacterium leprae (177 aa) FASTA scores: opt: 1149, E(): 1.6e-64, (96.6% identity in 177 aa overlap); and Q9F9R0 HYPOTHETICAL 18.5 KDA PROTEIN from Mycobacterium paratuberculosis (177 aa), FASTA scores: opt: 1139, E(): 6.8e-64, (96.6% identity in 177 aa overlap).	Q7TVI8	No	conserved hypotheticals								Q7TVI8	A0A1R3Y5E9				Rv3847		Rv3847			
NC_002945.3	Mycobrowser_v4	CDS	4241329	4241958	.	-	0	Mb3860c	Mb3860c		TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)	Mb3860c, -, len: 209 aa. Equivalent to Rv3830c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable transcriptional regulator tetR family, similar to others e.g. P39885|TCMR_STRGA TETRACENOMYCIN C TRANSCRIPTIONAL REPRESSOR from Streptomyces glaucescens (226 aa) FASTA scores: opt: 255, E(): 6.1e-10, (33.65% identity in 202 aa overlap); Q9RDR0|SC4A7.02 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (227 aa) FASTA scores: opt: 230, E(): 2.8e-08, (30.05% identity in 213 aa overlap); Q9EWU3|3SC5B7.06 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 221, E(): 1.2e-07, (32.05% identity in 181 aa overlap); Q9AJ68|BUTR PUTATIVE TRANSCRIPTIONAL REPRESSOR from Streptomyces cinnamonensis (268 aa), FASTA scores: opt: 216, E(): 2.7e-07, (37.8% identity in 119 aa overlap); etc. Contains possible helix-turn-helix motif from aa 33-54, Score 1699 (+4.97 SD). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TVK3	No	regulatory proteins							IPR001647,IPR009057,IPR015893,IPR023772	Q7TVK3	A0A1R3Y5C7				Rv3830c		Rv3830c			
NC_002945.3	Mycobrowser_v4	CDS	4243140	4243931	.	+	0	Mb3863	Mb3863		TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARAC-FAMILY)	Mb3863, -, len: 263 aa. Equivalent to Rv3833, len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Probable transcriptional regulator belonging to araC family,similar to others e.g. Q9KYN4|SC9H11.05 PUTATIVE ARAC-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42,(50.45% identity in 232 aa overlap); Q9HXH2|PA3830 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26,(34.85% identity in 238 aa overlap); Q9HX87|PA3927 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 496, E(): 1.3e-25,(36.45% identity in 266 aa overlap); P76241|YEAM_ECOLI|B1790 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 (273 aa) FASTA scores: opt: 388, E(): 1.9e-18, (30.5% identity in 223 aa overlap); etc. Contains probable helix-turn-helix motif from aa 164-185, Score 2014 (+6.05 SD). SEEMS TO BELONG TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TVK0	No	regulatory proteins							IPR009057,IPR011051,IPR013096,IPR014710,IPR018060	Q7TVK0	A0A1R3Y5E1				Rv3833		Rv3833			
NC_002945.3	Mycobrowser_v4	CDS	4260956	4261240	.	+	0	Mb3881	Mb3881		POSSIBLE MEMBRANE PROTEIN	Mb3881, -, len: 94 aa. Equivalent to Rv3851, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Possible membrane protein.	Q7TVI4	No	cell wall and cell processes								Q7TVI4	A0A1R3Y5G2				Rv3851		Rv3851			
NC_002945.3	Mycobrowser_v4	CDS	4246674	4247024	.	+	0	Mb3866	Mb3866		CONSERVED HYPOTHETICAL PROTEIN	Mb3866, -, len: 116 aa. Similar to Rv3836, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 115 aa overlap). Conserved hypothetical protein, highly similar to Q9RKJ2|SCD25.30 HYPOTHETICAL 13.1 KDA PROTEIN from Streptomyces coelicolor (116 aa),FASTA scores: opt: 395, E(): 3.3e-19, (54.4% identity in 114 aa overlap); and similar to CAC47753|SMC0379 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (144 aa) FASTA scores: opt: 194,E(): 6e-06, (33.05% identity in 109 aa overlap); and Q98E37|MLL4425 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 184,E(): 3.7e-05, (29.75% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa).	Q7TVJ8	No								IPR010428	Q7TVJ8	A0A1R3Y6V4									
NC_002945.3	Mycobrowser_v4	CDS	4249841	4250254	.	+	0	Mb3870	Mb3870		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN	Mb3870, -, len: 137 aa. Equivalent to Rv3840, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Possible transcriptional regulator, highly similar in part to PSR PROTEINS (PENICILLIN BINDING PROTEIN REPRESSORS) e.g. Q47828|PSR PSR PROTEIN from Enterococcus hirae (293 aa) FASTA scores: opt: 221, E(): 2.2e-07, (41.65% identity in 108 aa overlap); O86213|PSRFM PSRFM PROTEIN (FRAGMENT) from Enterococcus hirae (171 aa), FASTA scores: opt: 202,E(): 2.4e-06, (40.75% identity in 108 aa overlap); Q47865|PSR PENICILLIN BINDING PROTEIN REPRESSOR from Enterococcus hirae (148 aa), FASTA scores: opt: 201, E(): 2.5e-06, (51.65% identity in 60 aa overlap); etc. Also highly similar in part to other transcriptional regulators e.g. BAB57524|MSRR PEPTIDE METHIONINE SULFOXIDE REDUCTASE REGULATOR from Staphylococcus aureus subsp. aureus Mu50 (327 aa), FASTA scores: opt: 195, E(): 1.2e-05, (36.7% identity in 109 aa overlap); Q99Q02|MSRR|SA1195 PEPTIDE METHIONINE SULFOXIDE REDUCTASE REGULATOR from Staphylococcus aureus subsp. aureus N315, and Staphylococcus aureus (327 aa), FASTA scores: opt: 192,E(): 1.9e-05, (36.7% identity in 109 aa overlap); Q9K6Q8|LYTR|BH3670 ATTENUATOR FOR LYTABC AND LYTR EXPRESSION from Bacillus halodurans (304 aa), FASTA scores: opt: 171, E(): 0.00041, (34.5% identity in 113 aa overlap); etc.	Q7TVJ4	No	regulatory proteins							IPR004474	Q7TVJ4	A0A1R3Y5D3				Rv3840		Rv3840			
NC_002945.3	Mycobrowser_v4	CDS	4255048	4255539	.	+	0	Mb3874	Mb3874		possible transposase	Mb3874, -, len: 163 aa. Equivalent to Rv3844, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Possible transposase,identical to P96234|Rv3348|MTV004.04 PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis. Also some similarity with others e.g. N-terminal part of P19834|YI11_STRCL INSERTION ELEMENT IS116 HYPOTHETICAL 44.8 KDA PROTEIN from Streptomyces clavuligerus (399 aa) FASTA scores: opt: 146,E(): 0.017, (29.1% identity in 158 aa overlap).	Q7TTJ5	No	insertion seqs and phages							IPR002525	Q7TTJ5	A0A0G2QBZ4				Rv3844		Rv3844			
NC_002945.3	Mycobrowser_v4	CDS	3911032	3912159	.	-	0	Mb3561c	Mb3561c		HYPOTHETICAL PROTEIN	Mb3561c, -, len: 375 aa. Equivalent to Rv3531c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Hypothetical unknown protein.	Q7TWA0,A0A1R3Y4J9	No	conserved hypotheticals			A0A1R3Y4J9				IPR010621	Q7TWA0					Rv3531c		Rv3531c			
NC_002945.3	Mycobrowser_v4	CDS	4258599	4259507	.	+	0	Mb3878	Mb3878		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3878, -, len: 302 aa. Equivalent to Rv3848, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Probable conserved transmembrane protein, similar to hypothetical (transmembrane) proteins e.g. Q9HVG2|PA4629 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (192 aa), FASTA scores: opt: 304, E(): 5.3e-11, (35.05% identity in 174 aa overlap); Q9A5S7|CC2370 HYPOTHETICAL PROTEIN from Caulobacter crescentus (207 aa), FASTA scores: opt: 285,E(): 7.4e-10, (29.9% identity in 184 aa overlap); Q9KY43|SCC8A.05c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (193 aa), FASTA scores: opt: 245,E(): 1.6e-07, (32.8% identity in 195 aa overlap); etc.	Q7TVI7	No	cell wall and cell processes							IPR001727	Q7TVI7	A0A1R3Y5F1				Rv3848		Rv3848			
NC_002945.3	Mycobrowser_v4	CDS	4264674	4265681	.	-	0	Mb3886c	Mb3886c		CONSERVED HYPOTHETICAL PROTEIN	Mb3886c, -, len: 335 aa. Equivalent to Rv3856c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Conserved hypothetical protein, highly similar to various proteins from diverse organisms e.g. Q9EWR3|3SCF60.21 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (372 aa) FASTA scores: opt: 1286, E(): 2.4e-73, (64.0% identity in 336 aa overlap); P72464|ORF1 from Streptomyces lividans (343 aa), FASTA scores: opt: 1275, E(): 1.1e-72, (60.1% identity in 336 aa overlap); Q9K899|BH3107 DNA-DEPENDENT DNA POLYMERASE BETA CHAIN from Bacillus halodurans (571 aa), FASTA scores: opt: 592, E(): 1.2e-29, (39.15% identity in 240 aa overlap); etc.	Q7TVI0	No	conserved hypotheticals							IPR003141,IPR004013,IPR010996,IPR016195,IPR017078,IPR027421	Q7TVI0	A0A1R3Y5G8				Rv3856c		Rv3856c			
NC_002945.3	Mycobrowser_v4	CDS	4265690	4265887	.	-	0	Mb3887c	Mb3887c		POSSIBLE MEMBRANE PROTEIN	Mb3887c, -, len: 65 aa. Equivalent to Rv3857c, len: 65 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 65 aa overlap). Possible membrane protein.	Q7TVH9	No	cell wall and cell processes								Q7TVH9	A0A1R3Y5F2				Rv3857c		Rv3857c			
NC_002945.3	Mycobrowser_v4	CDS	4273050	4274222	.	+	0	Mb3890	Mb3890		conserved protein	Mb3890, -, len: 390 aa. Equivalent to Rv3860, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 390 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 (586 aa),FASTA scores: opt: 484, E(): 5.5e-14, (29.95% identity in 407 aa overlap); O33082|MLCB628.11c (478 aa) FASTA scores: opt: 484, E(): 4.8e-14, (29.95% identity in 407 aa overlap); etc. Also some similarity with O86637|SC3C3.03c HYPOTHETICAL 112.1 KDA PROTEIN from Streptomyces coelicolor(1083 aa), FASTA scores: opt: 483, E(): 9.6e-14,(30.45% identity in 404 aa overlap). And some similarity with other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O05456|Rv3888c|MTCY15F10.24 HYPOTHETICAL 37.7 KDA PROTEIN (341 aa), FASTA scores: opt: 603, E(): 2.8e-19, (35.2% identity in 284 aa overlap); O06396|Rv0530|MTCY25D10.09 HYPOTHETICAL 43.0 KDA PROTEIN (405 aa), FASTA scores: opt: 538, E(): 2e-16, (31.0% identity in 371 aa overlap); O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 475,E(): 1.5e-13, (30.2% identity in 391 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TVH6	No	conserved hypotheticals							IPR025669,IPR027417	Q7TVH6	A0A1R3Y5G0				Rv3860		Rv3860			
NC_002945.3	Mycobrowser_v4	CDS	4275121	4276299	.	+	0	Mb3893	Mb3893		unknown alanine rich protein	Mb3893, -, len: 392 aa. Equivalent to Rv3863, len: 392 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 392 aa overlap). Hypothetical unknown ala-rich protein.	Q7TVH3	No	conserved hypotheticals							IPR008984	Q7TVH3	A0A1R3Y6X7				Rv3863		Rv3863			
NC_002945.3	Mycobrowser_v4	CDS	4315942	4316808	.	-	0	Mb3926c	Mb3926c		CONSERVED HYPOTHETICAL PROTEIN	Mb3926c, -, len: 288 aa. Similar to Rv3896c, len: 302 aa (first GTG taken, although TBparse suggests TTG at 16079), from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 249 aa overlap). Putative conserved ala-rich protein. C-terminus highly similar to C-terminal end of other proteins e.g. Q9XAS4|SC10A7.01 HYPOTHETICAL 17.2 KDA PROTEIN from Streptomyces coelicolor (244 aa),FASTA scores: opt: 255, E(): 1.4e-08, (32.0% identity in 222 aa overlap); CAC44611|STBAC16H6.32 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (172 aa), FASTA scores: opt: 214, E(): 3.4e-06, (42.55% identity in 94 aa overlap); Q38352|ORF360 from Lactococcus delbrueckii bacteriophage LL-H (360 aa), FASTA scores: opt: 211, E(): 9.5e-06, (40.0% identity in 115 aa overlap); P54334|XKDO_BACSU|XKDO PHAGE-LIKE ELEMENT PBSX PROTEIN from Bacillus subtilis (1332 aa), FASTA scores: opt: 209,E(): 3.6e-05, (38.35% identity in 86 aa overlap); etc. Also similar to P71594|P71594|Rv0024|MTCY10H4.24 HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium tuberculosis (281 aa), FASTA scores: opt: 265, E(): 3.9e-09, (29.25% identity in 287 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a product with a different COOH part than in Mycobacterium tuberculosis (288 aa versus 302 aa).	Q7TVE4	No								IPR008258,IPR023346	Q7TVE4	A0A1R3Y5K2									
NC_002945.3	Mycobrowser_v4	CDS	4242030	4242512	.	+	0	Mb3861	Mb3861		HYPOTHETICAL PROTEIN	Mb3861, -, len: 160 aa. Equivalent to Rv3831, len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein.	Q7TVK2,A0A1R3Y5D2	No	conserved hypotheticals			A0A1R3Y5D2				IPR021362	Q7TVK2					Rv3831		Rv3831			
NC_002945.3	Mycobrowser_v4	CDS	4316958	4317947	.	-	0	Mb3927c	Mb3927c		CONSERVED HYPOTHETICAL PROTEIN	Mb3927c, -, len: 329 aa. Equivalent to Rv3898c and Rv3897c, len: 110 aa and 210 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 110 aa overlap and 98.8% identity in 168 aa overlap). Conserved hypothetical proteins. Highly similar, but in part, to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 HYPOTHETICAL 30.8 KDA PROTEIN from Mycobacterium tuberculosis (314 aa) FASTA scores: opt: 204, E(): 0.00042, (50.6% identity in 81 aa overlap) and FASTA scores: opt: 815, E(): 4.7e-26,(73.05% identity in 167 aa overlap). Similarity suggests it should be in frame with next ORF and that the stop codon could be read through, the sequence appears to be correct. Homology lost upstream at 15138 gatc sequence may suggest discontinuity due to chimerism in cY15F10 or cY49. Similarity to MTCY49.22 suggests that this is a continuation of MTCY15F10.14. There is a frameshift mutation near 3'-end with respect to this sequence as well, similarity to MTCY49.22 continues in an overlapping ORF. Sequence appears to be correct. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis, a single base transition (t-c) leads to a single product.	Q7TVE3	No	conserved hypotheticals								Q7TVE3	A0A1R3Y5K4				Rv3898c		Rv3898c			
NC_002945.3	Mycobrowser_v4	CDS	4318109	4318990	.	-	0	Mb3928c	Mb3928c		CONSERVED HYPOTHETICAL PROTEIN	Mb3928c, -, len: 293 aa. Equivalent to 3' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 293 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product.	Q7TVE2	No									Q7TVE2	A0A1R3Y5K1									
NC_002945.3	Mycobrowser_v4	CDS	4318597	4319340	.	-	0	Mb3929c	Mb3929c		CONSERVED HYPOTHETICAL PROTEIN	Mb3929c, -, len: 247 aa. Equivalent to 5' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (90.8% identity in 130 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. In Mycobacterium tuberculosis strain H37Rv,Rv3899c (len: 410 aa) exists as a single gene on a single reading frame. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product.		No																			
NC_002945.3	Mycobrowser_v4	CDS	4319334	4320269	.	-	0	Mb3930c	Mb3930c		CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN	Mb3930c, -, len: 311 aa. Equivalent to Rv3900c,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 311 aa overlap). Conserved hypothetical ala-rich protein, highly similar to N-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN from Mycobacterium tuberculosis (721 aa), FASTA scores: opt: 592, E(): 2.7e-22, (37.15% identity in 280 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct.	Q7TVE1	No	conserved hypotheticals								Q7TVE1	A0A1R3Y5L5				Rv3900c		Rv3900c			
NC_002945.3	Mycobrowser_v4	CDS	4321853	4324393	.	-	0	Mb3933c	Mb3933c		HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN	Mb3933c, -, len: 846 aa. Equivalent to Rv3903c,len: 846 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 846 aa overlap). Hypothetical unknown ala-, pro-rich protein.	Q7TVD8	No	conserved hypotheticals							IPR025331	Q7TVD8	A0A1R3Y6Y7				Rv3903c		Rv3903c			
NC_002945.3	Mycobrowser_v4	CDS	4325058	4325567	.	-	0	Mb3936c	Mb3936c		CONSERVED HYPOTHETICAL PROTEIN	Mb3936c, -, len: 169 aa. Equivalent to Rv3906c,len: 169 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 169 aa overlap). Conserved hypothetical protein, strongly related to Q50578|AT9S (SOD related in Escherichia coli) from Mycobacterium tuberculosis strain AOYAMA B (155 aa), but apparently different as flanking sequences differ and shorter 43 aa,FASTA scores: opt: 548, E(): 1.3e-26, (79.4% identity in 102 aa overlap). Selfmarch results suggest that Rv3906c is not related to any other hypothetical protein from M. tuberculosis strain H37Rv except itself. Shows also similarity with Q9VFR2|CG9297 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (930 aa), FASTA scores: opt: 221, E(): 4.9e-06, (36.95% identity in 157 aa overlap); Q9HQ55|CBP|VNG1320G CALCIUM-BINDING PROTEIN HOMOLOGY from Halobacterium sp. strain NRC-1 (385 aa) FASTA scores: opt: 143, E(): 0.13, (35.65% identity in 160 aa overlap); Q24795 CALCIUM-BINDING PROTEIN (FRAGMENT) from Echinococcus granulosus (338 aa), FASTA scores: opt: 140, E(): 0.17, (33.95% identity in 156 aa overlap).	Q7TVD5	No	conserved hypotheticals								Q7TVD5	A0A1R3Y5L6				Rv3906c		Rv3906c			
NC_002945.3	Mycobrowser_v4	CDS	4328153	4330561	.	+	0	Mb3939	Mb3939		conserved protein	Mb3939, -, len: 802 aa. Equivalent to Rv3909, len: 802 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 802 aa overlap). Conserved hypothetical protein, equivalent to Q9CCY0|ML2699 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (797 aa) FASTA scores: opt: 3777, E(): 8.8e-206, (72.35% identity in 803 aa overlap). Note that the N-terminal end is highly similar to Q50196|L222-ORF7 (286 aa), FASTA scores: opt: 1213,E(): 2.7e-61, (71.75% identity in 255 aa overlap); and the C-terminal end is highly similar to Q50197|L222-ORF8 also from Mycobacterium leprae (512 aa) FASTA scores: opt: 2375, E(): 9.9e-127, (71.8% identity in 518 aa overlap). Shows some similarity with N-terminal end of Q9I2M3|PA1874 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (2468 aa), FASTA scores: opt: 171, E(): 0.13, (22.9% identity in 672 aa overlap).	Q7TVD2	No	conserved hypotheticals								Q7TVD2	A0A1R3Y5N7				Rv3909		Rv3909			
NC_002945.3	Mycobrowser_v4	CDS	4337152	4338372	.	+	0	Mb3946	Mb3946		probable peptidoglycan hydrolase	Mb3946, -, len: 406 aa. Equivalent to Rv3915, len: 406 aa, from Myobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable hydrolase (EC 3.-.-.-), equivalent to Q9CCX8|ML2704 PUTATIVE HYDROLASE from Mycobacterium leprae (406 aa) FASTA scores: opt: 2341, E(): 2.7e-138, (86.95% identity in 406 aa overlap); the N-terminal end is highly similar to Q59535 N-ACETYMURAMYL-L-ALANINE AMIDASE (EC 3.5.1.28) from Mycobacterium leprae (205 aa), FASTA scores: opt: 1046,E(): 5.7e-58, (84.85% identity in 185 aa overlap). Also similar to other hydrolases (especially amidases (EC 3.5.-.-)) e.g. C-terminal end of Q9K6R3|LYTC|BH3665 N-ACETYLMURAMOYL-L-ALANINE AMIDASE (MAJOR AUTOLYSIN) from Bacillus halodurans (588 aa), FASTA scores: opt: 363, E(): 4.3e-15, (33.15% identity in 356 aa overlap); Q9PKC7|TC0539 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE from Chlamydia muridarum (268 aa), FASTA scores: opt: 285,E(): 1.6e-10, (26.05% identity in 242 aa overlap) (RV3915 product appears longer 127 aa); Q9S596|PDCA PENICILLIN-RESISTANT DD-CARBOXYPEPTIDASE (EC 3.4.-.-) from Myxococcus xanthus (302 aa), FASTA scores: opt: 270, E(): 1.5e-09, (39.85% identity in 158 aa overlap); etc. Note that previously known as cwlM.	Q7TVC7	No	intermediary metabolism and respiration							IPR002477,IPR002508	Q7TVC7	A0A1R3Y5M1				Rv3915		Rv3915			
NC_002945.3	Mycobrowser_v4	CDS	4342294	4342857	.	-	0	Mb3951c	Mb3951c		conserved protein similar to jag protein	Mb3951c, -, len: 187 aa. Equivalent to Rv3920c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Hypothetical protein,similar to JAG protein, equivalent to Q9L7M2 HYPOTHETICAL 20.1 KDA PROTEIN from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 HYPOTHETICAL PROTEIN SIMILAR TO JAG PROTEIN SPOIIIJ ASSOCIATED PROTEIN IN BACILLUS SUBTILIS from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44,(73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|JAG JAG-LIKE PROTEIN from Streptomyces coelicolor (170 aa), FASTA scores: opt: 593, E(): 6.7e-28, (62.85% identity in 167 aa overlap); Q9RCA6|JAG|BH4063 JAG PROTEIN HOMOLOG from Bacillus halodurans (207 aa), FASTA scores: opt: 282, E(): 1.1e-09, (35.0% identity in 140 aa overlap); Q9X1H1|TM1460 PUTATIVE JAG PROTEIN, PUTATIVE from Thermotoga maritima (221 aa), FASTA scores: opt: 258, E(): 3e-08, (31.9% identity in 138 aa overlap);Q01620|JAG_BACSU JAG PROTEIN (SPOIIIJ ASSOCIATED PROTEIN) from Bacillus subtilis (208 aa), FASTA scores: opt: 196, E(): 0.00012, (28.05% identity in 139 aa overlap); etc.	Q7TVC4	No	conserved hypotheticals							IPR001374	Q7TVC4	A0A1R3Y5N8				Rv3920c		Rv3920c			
NC_002945.3	Mycobrowser_v4	CDS	4255554	4255913	.	+	0	Mb3875	Mb3875		HYPOTHETICAL PROTEIN	Mb3875, -, len: 119 aa. Equivalent to Rv3845, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical unknown protein. Contains PS01137 Hypothetical YBL055c/yjjV family signature 1.	Q7TVJ0,A0A1R3Y5F9	No	conserved hypotheticals			A0A1R3Y5F9					Q7TVJ0					Rv3845		Rv3845			
NC_002945.3	Mycobrowser_v4	CDS	4321326	4321856	.	-	0	Mb3932c	Mb3932c		HYPOTHETICAL PROTEIN	Mb3932c, -, len: 176 aa. Equivalent to Rv3902c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Hypothetical unknown protein.	Q7TVD9,A0A1R3Y5N5	No	conserved hypotheticals	4O6G		A0A1R3Y5N5					Q7TVD9					Rv3902c		Rv3902c			
NC_002945.3	Mycobrowser_v4	CDS	4342929	4344029	.	-	0	Mb3952c	Mb3952c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb3952c, -, len: 366 aa. Equivalent to Rv3921c,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 366 aa overlap). Probable conserved transmembrane protein, equivalent to Q9L7M1 HYPOTHETICAL 39.2 KDA PROTEIN from Mycobacterium paratuberculosis (353 aa), FASTA scores: opt: 2001, E(): 8.4e-100, (83.05% identity in 366 aa overlap); Q9CCX6|ML2710 PUTATIVE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (380 aa), FASTA scores: opt: 1929, E(): 6.2e-96, (77.1% identity in 380 aa overlap); Q50205 CDS 27 on L222 from Mycobacterium leprae (312 aa) FASTA scores: opt: 1770,E(): 1.6e-87, (88.2% identity in 288 aa overlap). Also similar to other e.g. O54569|STH24.05 INNER MEMBRANE PROTEIN. from Streptomyces coelicolor (431 aa), FASTA scores: opt: 412, E(): 6.5e-15, (33.45% identity in 266 aa overlap); O84253|CT251 60 KDA INNER MEMBRANE PROTEIN from Chlamydia trachomatis (787 aa), FASTA scores: opt: 304,E(): 6e-09, (27.9% identity in 269 aa overlap); P29431|60IM_BUCAP 60 KDA INNER-MEMBRANE PROTEIN HOMOLOG from Buchnera aphidicola (subsp. Schizaphis graminum) (536 aa), FASTA scores: opt: 282, E(): 6.7e-08, (36.1% identity in 108 aa overlap); etc.	X2BPQ9,P65627	No	cell wall and cell processes								X2BPQ9,P65627	P65627				Rv3921c		Rv3921c			
NC_002945.3	Mycobrowser_v4	CDS	4344013	4344375	.	-	0	Mb3953c	Mb3953c		POSSIBLE HEMOLYSIN	Mb3953c, -, len: 120 aa. Equivalent to Rv3922c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). Possible hemolysin,highly similar to Q9L7M0|YIDD_MYCPA HYPOTHETICAL 12.4 KDA PROTEIN from Mycobacterium paratuberculosis (115 aa),FASTA scores: opt: 521, E(): 1.9e-29, (65.2% identity in 112 aa overlap). Also highly similar to Q44066|HLYA_AERHY PUTATIVE ALPHA-HEMOLYSIN from Aeromonas hydrophila (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap); and to many bacterial hypothetical proteins from bacterium e.g. P22847|YIDD_ECOLI|B3704.1 HYPOTHETICAL PROTEIN from Escherichia coli strain K12 (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap).	X2BQ10,P67301	No	virulence, detoxification, adaptation								X2BQ10,P67301	P67301				Rv3922c		Rv3922c			
NC_002945.3	Mycobrowser_v4	CDS	2523243	2523575	.	-	0	Mb2292c	Mb2292c		HYPOTHETICAL PROTEIN	Mb2292c, -, len: 110 aa. Equivalent to Rv2269c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 110 aa overlap). Unknown protein.	X2BKC5,P64966	No	conserved hypotheticals			P64966					X2BKC5					Rv2269c		Rv2269c			
NC_002945.3	Mycobrowser_v4	CDS	1263293	1263529	.	+	0	Mb1165	Mb1165		HYPOTHETICAL PROTEIN	Mb1165, -, len: 78 aa. Equivalent to Rv1134, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 78 aa overlap). Hypothetical unknown protein.	Q7U0K6,A0A1R3XXT7	No	conserved hypotheticals			A0A1R3XXT7					Q7U0K6					Rv1134		Rv1134			
NC_002945.3	Mycobrowser_v4	CDS	3624559	3624936	.	-	0	Mb3317c	Mb3317c		POSSIBLE TRANSMEMBRANE PROTEIN	Mb3317c, -, len: 125 aa. Equivalent to Rv3289c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Possible transmembrane protein, showing slight similarity to other membrane proteins or glycoproteins.	Q7TWT3,A0A1R3Y4E6	No	cell wall and cell processes			A0A1R3Y4E6					Q7TWT3					Rv3289c		Rv3289c			
NC_002945.3	Mycobrowser_v4	CDS	1800619	1801059	.	+	0	Mb1641	Mb1641		probable membrane protein	Mb1641, -, len: 146 aa. Equivalent to Rv1615, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Probable membrane protein.	Q7VEW4,A0A1R3XYU1	No	cell wall and cell processes			A0A1R3XYU1				IPR007829	Q7VEW4					Rv1615		Rv1615			
NC_002945.3	Mycobrowser_v4	CDS	87243	87836	.	-	0	Mb0081c	Mb0081c		HYPOTHETICAL PROTEIN	Mb0081c, -, len: 197 aa. Equivalent to Rv0078A,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Hypothetical unknown protein.	Q7U2W4,A0A1R3XU93	No	conserved hypotheticals			A0A1R3XU93				IPR014942	Q7U2W4					Rv0078A		Rv0078A			
NC_002945.3	Mycobrowser_v4	CDS	238088	238591	.	-	0	Mb0207c	Mb0207c		conserved protein	Mb0207c, -, len: 167 aa. Equivalent to Rv0201c,len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Conserved hypothetical protein, equivalent to Z95398|MLCL622.15c from Mycobacterium leprae (170 aa), FASTA scores: opt: 646, E(): 0, (63.9% identity in 158 aa overlap).	Q7U2K9,A0A1R3XWS9	No	conserved hypotheticals			A0A1R3XWS9					Q7U2K9					Rv0201c		Rv0201c			
NC_002945.3	Mycobrowser_v4	CDS	2049896	2049976	.	+	0	Mb1847	Mb1847		CONSERVED HYPOTHETICAL PROTEIN	Mb1847, -, len: 26 aa. Equivalent to Rv1816A, len: 26 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 26 aa overlap). Conserved hypothetical protein.	Q7TZH2,A0A1R3XZE9	No				A0A1R3XZE9					Q7TZH2					Rv1816A		Rv1816A			
NC_002945.3	Mycobrowser_v4	CDS	2113893	2114579	.	+	0	Mb1905	Mb1905		unknown protein	Mb1905, -, len: 228 aa. Equivalent to Rv1874, len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Hypothetical unknown protein.	Q7TZE2,A0A1R3XZN4	No	conserved hypotheticals			A0A1R3XZN4				IPR009799,IPR011008	Q7TZE2					Rv1874		Rv1874			
NC_002945.3	Mycobrowser_v4	CDS	3807367	3807678	.	-	0	Mb3470c	Mb3470c		HYPOTHETICAL PROTEIN	Mb3470c, -, len: 103 aa. Equivalent to Rv3440c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Hypothetical unknown protein.	Q7TWI0,A0A1R3Y4B8	No	conserved hypotheticals			A0A1R3Y4B8					Q7TWI0					Rv3440c		Rv3440c			
NC_002945.3	Mycobrowser_v4	CDS	3855513	3856091	.	+	0	Mb3521	Mb3521		unknown protein	Mb3521, -, len: 192 aa. Equivalent to Rv3491, len: 192 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 192 aa overlap). Hypothetical unknown protein. No significant homology with other proteins.	Q7TWE0,A0A1R3Y4F8	No	conserved hypotheticals			A0A1R3Y4F8					Q7TWE0					Rv3491		Rv3491			
NC_002945.3	Mycobrowser_v4	CDS	1171487	1172602	.	-	0	Mb1077c	Mb1077c		HYPOTHETICAL PROTEIN	Mb1077c, -, len: 371 aa. Equivalent to Rv1048c,len: 371 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 371 aa overlap). Hypothetical unknown protein.	Q7U0S8,A0A1R3XX74	No	conserved hypotheticals			A0A1R3XX74					Q7U0S8					Rv1048c		Rv1048c			
NC_002945.3	Mycobrowser_v4	CDS	3323259	3323882	.	+	0	Mb3033	Mb3033		HYPOTHETICAL PROTEIN	Mb3033, -, len: 207 aa. Equivalent to Rv3008, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 207 aa overlap). Hypothetical unknown protein. Start uncertain.	Q7TXG3,A0A1R3Y305	No	conserved hypotheticals			A0A1R3Y305					Q7TXG3					Rv3008		Rv3008			
NC_002945.3	Mycobrowser_v4	CDS	262479	263027	.	+	0	Mb0225	Mb0225		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0225, -, len: 182 aa. Equivalent to Rv0219, len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable conserved transmembrane protein, showing similarity with CAB76992.1|AL159178 putative lipoprotein from Streptomyces coelicolor (163 aa).	Q7U2J4,A0A1R3XUQ8	No	cell wall and cell processes			A0A1R3XUQ8					Q7U2J4					Rv0219		Rv0219			
NC_002945.3	Mycobrowser_v4	CDS	330073	330993	.	+	0	Mb0282	Mb0282		CONSERVED HYPOTHETICAL PROTEIN	Mb0282, -, len: 306 aa. Equivalent to Rv0276, len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 306 aa overlap). Conserved hypothetical protein, similar to Rv2237|Z70692|MTCY427.18 from Mycobacterium tuberculosis (296 aa), FASTA scores: opt: 874, E(): 0, (49.6% identity in 282 aa overlap).	Q7U2E0,A0A1R3XUU4	No	conserved hypotheticals			A0A1R3XUU4				IPR018713	Q7U2E0					Rv0276		Rv0276			
NC_002945.3	Mycobrowser_v4	CDS	457932	458840	.	-	0	Mb0388c	Mb0388c		HYPOTHETICAL PROTEIN	Mb0388c, -, len: 302 aa. Equivalent to Rv0381c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Hypothetical unknown protein. Equivalent to AAK44616.1 from Mycobacterium tuberculosis strain CDC1551 (254 aa) but longer 48 aa.	Q7U246,A0A1R3XV47	No	conserved hypotheticals			A0A1R3XV47					Q7U246					Rv0381c		Rv0381c			
NC_002945.3	Mycobrowser_v4	CDS	52815	53228	.	+	0	Mb0050	Mb0050		CONSERVED HYPOTHETICAL PROTEIN	Mb0050, -, len: 137 aa. Equivalent to Rv0049, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein, only equivalent to AL022118|MLCB1913_20 hypothetical protein from Mycobacterium leprae (138 aa), FASTA scores: opt: 768,E(): 0, (83.9% identity in 137 aa overlap).	X2BDV4,P64678	No	conserved hypotheticals			P64678					X2BDV4					Rv0049		Rv0049			
NC_002945.3	Mycobrowser_v4	CDS	85218	85607	.	-	0	Mb0078c	Mb0078c		PROBABLE MEMBRANE PROTEIN	Mb0078c, -, len: 129 aa. Equivalent to Rv0076c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Probable membrane protein, with membrane-spanning domain at C-terminus.	Q7U2W7,A0A1R3XVD6	No	cell wall and cell processes			A0A1R3XVD6					Q7U2W7					Rv0076c		Rv0076c			
NC_002945.3	Mycobrowser_v4	CDS	155858	156637	.	+	0	Mb0133	Mb0133		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	Mb0133, -, len: 259 aa. Equivalent to Rv0128, len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Probable conserved transmembrane protein, with some similarity to Rv3064c and other bacterial proteins e.g. AAK85977.1|AE007957|AGR_C_254p from Agrobacterium tumefaciens (206 aa).	Q7U2S6,A0A1R3XUF7	No	cell wall and cell processes			A0A1R3XUF7				IPR010699	Q7U2S6					Rv0128		Rv0128			
NC_002945.3	Mycobrowser_v4	CDS	843927	844064	.	-	0	Mb0771c	Mb0771c		HYPOTHETICAL PROTEIN (FRAGMENT)	Mb0771c, -, len: 45 aa. Equivalent to Rv0749A, len: 45 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 45 aa overlap). Conserved hypothetical protein (probably gene fragment), similar to part (aa 250-292) of Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 238, E(): 1.9e-13, (79.07% identity in 43 aa overlap).	Q7U1D0,A0A1R3XWA1	No	conserved hypotheticals			A0A1R3XWA1					Q7U1D0					Rv0749A		Rv0749A			
NC_002945.3	Mycobrowser_v4	CDS	2375048	2375635	.	-	0	Mb2158c	Mb2158c		conserved protein	Mb2158c, -, len: 195 aa. Equivalent to Rv2134c,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49789. FASTA best: Q49789 B2126_C3_228, opt: 1192, E( ): 0 (91.1% identity in 192 aa overlap)	Q7TZ01,A0A1R3Y123	No	conserved hypotheticals			A0A1R3Y123				IPR021441	Q7TZ01					Rv2134c		Rv2134c			
NC_002945.3	Mycobrowser_v4	CDS	844223	844468	.	+	0	Mb0772	Mb0772		CONSERVED HYPOTHETICAL PROTEIN	Mb0772, -, len: 81 aa. Equivalent to Rv0750, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing almost perfect overlap with C-terminus of Rv0740|MTV041_14 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (175 aa), FASTA scores: (93.8% identity in 81 aa overlap). Possible duplication.	Q7U1C9,A0A1R3XW98	No	conserved hypotheticals			A0A1R3XW98					Q7U1C9					Rv0750		Rv0750			
NC_002945.3	Mycobrowser_v4	CDS	2507046	2507549	.	+	0	Mb2277	Mb2277		Possible secreted unknown protein	Mb2277, -, len: 167 aa. Equivalent to Rv2253, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 167 aa overlap). Possible secreted protein; has potential N-terminal signal peptide.	Q7VEM9,A0A1R3Y0L7	No	cell wall and cell processes			A0A1R3Y0L7					Q7VEM9					Rv2253		Rv2253			
NC_002945.3	Mycobrowser_v4	CDS	1776936	1777601	.	+	0	Mb1617	Mb1617		PROBABLE TRANSMEMBRANE PROTEIN	Mb1617, -, len: 221 aa. Equivalent to Rv1591, len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 221 aa overlap). Probable transmembrane protein, similar to Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical Mycobacterium leprae protein (198 aa), FASTA results: opt: 802, E(): 0, (63.8% identity in 188 aa overlap).	X2BID8,P0A5F4,P0A5F4	No	cell wall and cell processes			P0A5F4					X2BID8,P0A5F4					Rv1591		Rv1591			
NC_002945.3	Mycobrowser_v4	CDS	1783660	1784418	.	+	0	Mb1623	Mb1623		HYPOTHETICAL PROTEIN	Mb1623, -, len: 252 aa. Equivalent to Rv1597, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 252 aa overlap). Hypothetical unknown protein.	Q7TZW3,A0A1R3XYT4	No	conserved hypotheticals			A0A1R3XYT4				IPR013216	Q7TZW3					Rv1597		Rv1597			
NC_002945.3	Mycobrowser_v4	CDS	2129976	2130383	.	+	0	Mb1924	Mb1924		conserved protein	Mb1924, -, len: 135 aa. Equivalent to Rv1891, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein. Equivalent to MLCB561.09|AL049571 hypothetical protein from Mycobacterium leprae (134 aa),FASTA scores: opt: 800, E(): 0, (79.7% identity in 133 aa overlap).	Q7TZC6,A0A1R3XZL9	No	conserved hypotheticals			A0A1R3XZL9					Q7TZC6					Rv1891		Rv1891			
NC_002945.3	Mycobrowser_v4	CDS	300060	300353	.	-	0	Mb0256c	Mb0256c		conserved protein	Mb0256c, -, len: 97 aa. Equivalent to Rv0250c, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Conserved hypothetical protein, equivalent to MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486 hypothetical protein from Mycobacterium leprae (98 aa),FASTA scores: opt: 478, E(): 4.4e-28, (72.6% identity in 95 aa overlap). Also similar to C-terminus of AC44316.1|AL596043|SCBAC31E11.05c hypothetical protein from Streptomyces coelicolor (146 aa).	Q7U2G4,A0A1R3XUS6	No	conserved hypotheticals			A0A1R3XUS6					Q7U2G4					Rv0250c		Rv0250c			
NC_002945.3	Mycobrowser_v4	CDS	1717129	1717563	.	-	0	Mb1559c	Mb1559c		CONSERVED HYPOTHETICAL PROTEIN	Mb1559c, -, len: 144 aa. Equivalent to Rv1532c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Conserved hypothetical protein, similar to P20378|YPHR_HALHA Hypothetical 15.6 kd protein from Halobacterium halobium (151 aa), FASTA scores: opt: 152, E():4.5e-05, (30.1% identity in 103 aa overlap).	Q7TZX6,A0A1R3XYK8	No	conserved hypotheticals			A0A1R3XYK8				IPR003736,IPR006683	Q7TZX6					Rv1532c		Rv1532c			
NC_002945.3	Mycobrowser_v4	CDS	1784439	1784849	.	-	0	Mb1624c	Mb1624c		conserved protein	Mb1624c, -, len: 136 aa. Equivalent to Rv1598c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Conserved hypothetical protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa).	Q7TZW2,A0A1R3XYT8	No	conserved hypotheticals			A0A1R3XYT8				IPR004378	Q7TZW2					Rv1598c		Rv1598c			
NC_002945.3	Mycobrowser_v4	CDS	2623336	2623653	.	+	0	Mb2396	Mb2396		CONSERVED HYPOTHETICAL PROTEIN	Mb2396, -, len: 105 aa. Equivalent to Rv2375, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Conserved hypothetical protein, highly similar to only CAC32314|2SCD60.09c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (98 aa), FASTA scores: opt: 425,E(): 5.7e-24, (63.25% identity in 98 aa overlap).	Q7TYR0,A0A1R3Y0Z8	No	conserved hypotheticals			A0A1R3Y0Z8				IPR014447	Q7TYR0					Rv2375		Rv2375			
NC_002945.3	Mycobrowser_v4	CDS	1215421	1215741	.	+	0	Mb1116A	Mb1116A		CONSERVED HYPOTHETICAL PROTEIN	Mb1116A, -, len: 106 aa. Equivalent to Rv1087A,len: 106 aa (fragment), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 106 aa overlap). Conserved hypothetical protein, highly similar to C-terminus of near ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE from Mycobacterium tuberculosis (262 aa), FASTA scores: opt: 200, E(): 1.1e-06, (57.9% identity in 76 aa overlap).	Q7U0P6,A0A1R3XXB7	No	cell wall and cell processes			A0A1R3XXB7				IPR001441	Q7U0P6					Rv1087A		Rv1087A			
NC_002945.3	Mycobrowser_v4	CDS	555332	555904	.	-	0	Mb0473c	Mb0473c		conserved protein	Mb0473c, -, len: 190 aa. Equivalent to Rv0464c,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 190 aa overlap). Conserved hypothetical protein, highly similar to CAC31982.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (188 aa). Also some similarity with Rv1531|AL022000|MTV045_5|D70820 hypothetical protein from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 9.6e-10, (30.9% identity in 175 aa overlap).	Q7U1X9,A0A1R3XVF8	No	conserved hypotheticals			A0A1R3XVF8				IPR003779	Q7U1X9					Rv0464c		Rv0464c			
NC_002945.3	Mycobrowser_v4	CDS	1394438	1395226	.	-	0	Mb1281c	Mb1281c		POSSIBLE MEMBRANE PROTEIN	Mb1281c, -, len: 262 aa. Equivalent to Rv1249c,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 262 aa overlap). Possible membrane protein. Start uncertain.	Q7U0A5,A0A1R3XZY1	No	cell wall and cell processes			A0A1R3XZY1					Q7U0A5					Rv1249c		Rv1249c			
NC_002945.3	Mycobrowser_v4	CDS	1443548	1443883	.	-	0	Mb1323c	Mb1323c		CONSERVED HYPOTHETICAL SECRETED PROTEIN	Mb1323c, -, len: 111 aa. Equivalent to Rv1291c,len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 111 aa overlap). Conserved hypothetical secreted protein, similar to others in Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU HYPOTHETICAL 11.6 KD PROTEIN (113 aa), FASTA score: opt: 246, E(): 1.7e-09, (40.0% identity in 110 aa overlap); Rv1804c,Rv1810, Rv0622, etc.	X2BHW7,P0A5E6	No	cell wall and cell processes			P0A5E6					X2BHW7					Rv1291c		Rv1291c			
NC_002945.3	Mycobrowser_v4	CDS	2186978	2187568	.	-	0	Mb1979c	Mb1979c		conserved protein	Mb1979c, -, len: 196 aa. Equivalent to Rv1944c,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Conserved hypothetical protein, similar to C-terminal part of SCE20.29|AL136058|CAB65585.1 hypothetical protein from Streptomyces coelicolor (338 aa), BLASTP scores,Identities = 37/131 (28%), Positives = 51/131 (38%).	Q7TZ88,A0A1R3XZV1	No	conserved hypotheticals			A0A1R3XZV1				IPR004027	Q7TZ88					Rv1944c		Rv1944c			
NC_002945.3	Mycobrowser_v4	CDS	308619	309074	.	-	0	Mb0264c	Mb0264c		CONSERVED HYPOTHETICAL PROTEIN	Mb0264c, -, len: 151 aa. Equivalent to Rv0258c,len: 151 aa (alternative start possible), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 151 aa overlap). Conserved hypothetical protein,showing some similarity to Rv1685c|MTCI125_6 from Mycobacterium tuberculosis (207 aa), FASTA scores: E(): 9.3e-07, (32.1% identity in 140 aa overlap). Also some similarity with AL049819|SCE7_13|T36295 probable transcription regulator from Streptomyces coelicolor (204 aa), FASTA scores: opt: 158, E(): 0.00052, (27.0% identity in 111 aa overlap).	Q7U2F7,A0A1R3XUS5	No	conserved hypotheticals			A0A1R3XUS5				IPR011075,IPR015893	Q7U2F7					Rv0258c		Rv0258c			
NC_002945.3	Mycobrowser_v4	CDS	1815436	1815927	.	-	0	Mb1654c	Mb1654c		conserved protein	Mb1654c, -, len: 163 aa. Equivalent to Rv1628c,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 163 aa overlap). Conserved hypothetical protein, some similarity to others e.g. Q51796 ACAC PROTEIN in Pyrococcus furiosus (136 aa), FASTA scores: opt: 199, E(): 4.6e-06, (34.7% identity in 121 aa overlap).	Q7TZV3,A0A1R3XYW6	No	conserved hypotheticals			A0A1R3XYW6				IPR002878,IPR012340,IPR022002	Q7TZV3					Rv1628c		Rv1628c			
NC_002945.3	Mycobrowser_v4	CDS	2216219	2216491	.	-	0	Mb2016c	Mb2016c		conserved protein	Mb2016c, -, len: 90 aa. Equivalent to Rv1993c, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Conserved hypothetical protein, very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap).	X2BJS9,P64914	No	conserved hypotheticals			P64914					X2BJS9					Rv1993c		Rv1993c			
NC_002945.3	Mycobrowser_v4	CDS	308180	308398	.	+	0	Mb0263	Mb0263		CONSERVED HYPOTHETICAL PROTEIN	Mb0263, -, len: 72 aa. Equivalent to Rv0257, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 72 aa overlap). Hypothetical protein,orthologue of ML1828A conserved hypothetical protein from Mycobacterium leprae. Replaced Rv0257c (older annotation). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa).	Q7U2F8,A0A1R3XUS7	No	conserved hypotheticals			A0A1R3XUS7					Q7U2F8					Rv0257		Rv0257			
NC_002945.3	Mycobrowser_v4	CDS	932959	933681	.	-	0	Mb0859c	Mb0859c		HYPOTHETICAL PROTEIN	Mb0859c, -, len: 240 aa. Equivalent to Rv0836c,len: 217 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 217 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa).	Q7U157,A0A1R3XWJ6	No	conserved hypotheticals			A0A1R3XWJ6				IPR014513	Q7U157					Rv0836c		Rv0836c			
NC_002945.3	Mycobrowser_v4	CDS	1416725	1417099	.	-	0	Mb1300c	Mb1300c		CONSERVED PROBABLE SECRETED PROTEIN	Mb1300c, -, len: 124 aa. Equivalent to Rv1269c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Conserved probable exported protein with putative N-terminal signal sequence. Similar to Mycobacterium tuberculosis protein Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30 (137 aa), FASTA scores: E(): 9e-21, (41.6% identity in 137 aa overlap).	X2BH85,P0A5E2	No	cell wall and cell processes			P0A5E2					X2BH85					Rv1269c		Rv1269c			
NC_002945.3	Mycobrowser_v4	CDS	2426639	2427028	.	-	0	Mb2208c	Mb2208c		CONSERVED HYPOTHETICAL PROTEIN	Mb2208c, -, len: 129 aa. Equivalent to Rv2186c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Conserved hypothetical protein, equivalent to hypothetical Mycobacterium leprae protein ML0888 (135 aa). FASTA scores: ML0888 opt: 704, E(): 2.9e-43; 80.000% identity in 130 aa overlap CAA18694.1| (AL022602).	Q7TYY0,A0A1R3Y0J5	No	conserved hypotheticals			A0A1R3Y0J5					Q7TYY0					Rv2186c		Rv2186c			
NC_002945.3	Mycobrowser_v4	CDS	990413	993061	.	-	0	Mb0914c	Mb0914c		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR-FAMILY)	Mb0914c, -, len: 882 aa. Equivalent to Rv0890c,len: 882 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 882 aa overlap). Probable transcriptional regulatory protein, LuxR family, highly similar (but shorter 238 aa in N-terminus) to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar (generally in part) to others e.g. T50568 probable multi-domain regulatory protein from Streptomyces coelicolor (1334 aa); P10957|NARL_ECOLI nitrate/nitrite response regulator protein from Escherichia coli (216 aa),FASTA scores: opt: 193, E(): 6e-06, (37.4% identity in 99 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. MTCY02B10_22, MTV008_44,MTV036_21, and MTCY31_24. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, and probable helix-turn helix motif from aa 836 to 857 (Score 1559, +4.50 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS.	X2BGB7,P59969,P59969	No	regulatory proteins			P59969					X2BGB7,P59969					Rv0890c		Rv0890c			
NC_002945.3	Mycobrowser_v4	CDS	4152175	4152357	.	-	0	Mb3797c	Mb3797c		PROBABLE REMNANT OF A TRANSPOSASE	Mb3797c, -, len: 60 aa. Equivalent to Rv3770A, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 204, E(): 1e-07, (80.5% identity in 41 aa overlap). Continuation of Rv3770B.	Q7TVQ3,A0A1R3Y5I5	No	insertion seqs and phages			A0A1R3Y5I5					Q7TVQ3					Rv3770A		Rv3770A			
NC_002945.3	Mycobrowser_v4	CDS	1002906	1003169	.	-	0	Mb0922c	Mb0922c		CONSERVED HYPOTHETICAL PROTEIN	Mb0922c, -, len: 87 aa. Equivalent to Rv0898c, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 87 aa overlap). Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap).	X2BGG5,P64754	No	conserved hypotheticals			P64754					X2BGG5					Rv0898c		Rv0898c			
NC_002945.3	Mycobrowser_v4	CDS	3077981	3078307	.	-	0	Mb2839c	Mb2839c		PROBABLE TRANSPOSASE	Mb2839c, -, len: 108 aa. Equivalent to Rv2815c,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Probable transposase,identical from aa 51 with P19772|YIA2_MYCTU PUTATIVE TRANSPOSASE (INSERTION ELEMENT IS986) from Mycobacterium tuberculosis (59 aa), FASTA scores: opt: 365, E(): 1.1e-19, (96.6% identity in 59 aa overlap); and other transposases.	X2BLL3,P59801,P59801	No	insertion seqs and phages			P59801					X2BLL3,P59801					Rv2815c		Rv2815c			
NC_002945.3	Mycobrowser_v4	CDS	1172835	1173281	.	+	0	Mb1078	Mb1078		PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN	Mb1078, -, len: 148 aa. Equivalent to Rv1049, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 148 aa overlap). Probable transcriptional repressor protein, similar to many e.g. P74870 NEGATIVE REGULATOR OF EMR LOCUS EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,(31.6% identity in 95 aa overlap). Contains probable helix-turn -helix motif at aa 58-79 (Score 1495, +4.28 SD).	Q7U0S7,A0A1R3XX75	No	regulatory proteins			A0A1R3XX75				IPR000835,IPR011991	Q7U0S7					Rv1049		Rv1049			
NC_002945.3	Mycobrowser_v4	CDS	1058113	1058430	.	-	0	Mb0973c	Mb0973c		chorismate mutase	Mb0973c, -, len: 105 aa. Equivalent to Rv0948c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 105 aa overlap). Conserved hypothetical protein, equivalent to NP_301237.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (105 aa). Also similar (except in N-terminus) to SCD63.16c|CAB82023.1|AL161755 hypothetical protein from Streptomyces coelicolor (110 aa); and to N-terminus of two chorismate mutase/prephenate dehydratase.	X2BGA2,P64768,P64768	No	intermediary metabolism and respiration			P64768					X2BGA2,P64768					Rv0948c		Rv0948c			
NC_002945.3	Mycobrowser_v4	CDS	3831221	3831889	.	+	0	Mb3495	Mb3495		CONSERVED HYPOTHETICAL PROTEIN	Mb3495, -, len: 222 aa. Equivalent to Rv3466, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(98.2% identity in 222 aa overlap). Conserved hypothetical ORF in REP13E12 repeat, but extending 5' of repeat. Has segment of identity to other REP13E12 ORF's e.g. MTCY336.16, MTCI65.15c, MTCY09F9.19, cMTCY251.14c.	Q7TWG5,A0A1R3Y485	No	insertion seqs and phages			A0A1R3Y485				IPR003870	Q7TWG5					Rv3466		Rv3466			
NC_002945.3	Mycobrowser_v4	CDS	963300	963581	.	+	0	Mb0886	Mb0886		CONSERVED HYPOTHETICAL PROTEIN	Mb0886, -, len: 93 aa. Equivalent to Rv0863, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, highly similar to NP_302418.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (74 aa). Also weakly similar in part to U82598|ECU82598_135 HYPOTHETICAL PROTEIN from Escherichia coli, FASTA scores: (32.4% identity in 71 aa overlap); and M74011|YEPYSCOP_8 HYPOTHETICAL PROTEIN from Yersinia enterocolitica (165 aa), FASTA scores: (38.6 identity in 57 aa overlap).	Q7U130,A0A1R3XX11	No	conserved hypotheticals			A0A1R3XX11					Q7U130					Rv0863		Rv0863			
NC_002945.3	Mycobrowser_v4	CDS	172401	173333	.	+	0	Mb0151	Mb0151		possible s-adenosylmethionine-dependent methyltransferase	Mb0151, -, len: 310 aa. Equivalent to Rv0146, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Conserved hypothetical protein, highly similar to others e.g. AC30975.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (304 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc.	X2BE60,Q7U2R2,Q7U2R2	No	lipid metabolism			Q7U2R2					X2BE60,Q7U2R2					Rv0146		Rv0146			
NC_002945.3	Mycobrowser_v4	CDS	464428	467685	.	+	0	Mb0393	Mb0393		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR/UHPA-FAMILY)	Mb0393, -, len: 1085 aa. Equivalent to Rv0386, len: 1085 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1085 aa overlap). Probable regulatory protein, LuxR/uhpA family, highly similar to CAC30706.1|AL583923 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar in part to other regulatory proteins e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); N-terminus of CAB92369.1|AL356612 putative AfsR-like regulatory protein from Streptomyces coelicolor (1114 aa); N-terminus of NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional regulator from Mesorhizobium loti (952 aa); AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores: opt: 224,E() : 1.1e-06, (26.1% identity in 867 aa overlap); etc. Also similar to many putative Mycobacterium tuberculosis regulatory proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA scores: opt: 3756, E(): 0, (56.7% identity in 1089 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature and probable helix-turn-helix motif at aa 1042-1063 (Score 1025, +2.68 S D). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7U243,A0A1R3XV59	No	regulatory proteins			A0A1R3XV59				IPR000767,IPR000792,IPR001054,IPR002182,IPR011990,IPR011991,IPR016032,IPR027417	Q7U243					Rv0386		Rv0386			
NC_002945.3	Mycobrowser_v4	CDS	2134686	2135117	.	-	0	Mb1932c	Mb1932c		CONSERVED HYPOTHETICAL PROTEIN	Mb1932c, -, len: 143 aa. Equivalent to Rv1897c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein. Some similarity to D63706|Q54235 ORF2 from Streptomyces griseus (149 aa), FASTA results: opt: 509, E(): 1.2e-28, (57.3% identity in 150 aa overlap); and Q45303 ORF1 PROTEIN from Corynebacterium glutamicum (144 aa), FASTA results: opt: 460, E(): 5.5e-23, (49.7% identity in 143 aa overlap).	X2BJL1,P63996,P63996	No	conserved hypotheticals			P63996					X2BJL1,P63996					Rv1897c		Rv1897c			
NC_002945.3	Mycobrowser_v4	CDS	1613289	1613714	.	-	0	Mb1474c	Mb1474c		unknown protein	Mb1474c, -, len: 141 aa. Equivalent to Rv1439c,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 141 aa overlap). Hypothetical unknown protein.	Q7U028,A0A1R3XYD4	No	conserved hypotheticals			A0A1R3XYD4				IPR009959	Q7U028					Rv1439c		Rv1439c			
NC_002945.3	Mycobrowser_v4	CDS	1265977	1266318	.	+	0	Mb1168	Mb1168		POSSIBLE ENOYL-COA HYDRATASE	Mb1168, -, len: 113 aa. Equivalent to Rv1136, len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 113 aa overlap). Probable enoyl-CoA hydratase (possible gene fragment) (EC 5.-.-.-). Some similarity to N-terminus of carnitine racemases and enoyl-CoA hydratases (but much shorter) e.g. I41014 carnitine racemase from Escherichia coli (297 aa), FASTA scores: opt: 258, E(): 2.5e-11, (44.5% identity in 110 aa overlap); and Rv0222 putative enoyl-CoA hydratase from M. tuberculosis (262 aa).	Q7U0K3,A0A1R3XXG3	No	lipid metabolism			A0A1R3XXG3				IPR001753	Q7U0K3					Rv1136		Rv1136			
NC_002945.3	Mycobrowser_v4	CDS	562873	563313	.	-	0	Mb0480c	Mb0480c		HYPOTHETICAL PROTEIN	Mb0480c, -, len: 146 aa. Equivalent to Rv0470A,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein, could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in Mycobacterium bovis and CDC1551. Weak hits to Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: 132, E(): 1.1, (39.35% identity in 61 aa overlap).	Q7U1X3,A0A1R3XVZ6	No	conserved hypotheticals			A0A1R3XVZ6				IPR000537	Q7U1X3					Rv0470A		Rv0470A			
NC_002945.3	Mycobrowser_v4	CDS	563244	563732	.	-	0	Mb0481c	Mb0481c		HYPOTHETICAL PROTEIN	Mb0481c, -, len: 162 aa. Equivalent to Rv0471c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Hypothetical unknown protein.	Q7U1X2,A0A1R3XVE8	No	conserved hypotheticals			A0A1R3XVE8					Q7U1X2					Rv0471c		Rv0471c			
NC_002945.3	Mycobrowser_v4	CDS	592626	592727	.	+	0	Mb0512A	Mb0512A		Conserved hypothetical protein	Mb0512A, len: 33 aa. Equivalent to Rv0500B len: 33 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 33 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Conserved hypothetical protein. Basic protein 18 of the 33 aa are Arg or Lys,with strong similarity to AL079345|SCE68_25 protein from Streptomyces coelicolor cosmid E6 (32 aa), FASTA scores: opt: 176, E(): 1e-06, (93.1% identity in 29 aa overlap). Same gene arrangement in both actinomycetes.	X2BF61,A0A1R3XVJ1	No	conserved hypotheticals			A0A1R3XVJ1					X2BF61					Rv0500B		Rv0500B			
NC_002945.3	Mycobrowser_v4	CDS	1887793	1888695	.	+	0	Mb1705	Mb1705		probable integral membrane protein	Mb1705, -, len: 300 aa. Equivalent to Rv1678, len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 300 aa overlap). Probable integral membrane protein.	Q7TZT2,A0A1R3XZ23	No	cell wall and cell processes			A0A1R3XZ23					Q7TZT2					Rv1678		Rv1678			
NC_002945.3	Mycobrowser_v4	CDS	33208	33537	.	+	0	Mb0031	Mb0031		conserved hypothetical protein	Mb0031, -, len: 109 aa. Equivalent to Rv0030, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Hypothetical unknown protein.	X2BDT4,P64672	No	conserved hypotheticals			P64672					X2BDT4					Rv0030		Rv0030			
NC_002945.3	Mycobrowser_v4	CDS	2939059	2939550	.	-	0	Mb2683c	Mb2683c		CONSERVED HYPOTHETICAL PROTEIN	Mb2683c, -, len: 163 aa. Equivalent to Rv2665A,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). Conserved hypothetical protein; N-terminus highly similar to N-terminus of Rv1046c from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 313, E(): 2.9e-11, (44.7% identity in 159 aa overlap). Alternative to Rv2665.	Q7TY58,A0A1R3Y1U6	No				A0A1R3Y1U6					Q7TY58					Rv2665A		Rv2665A			
NC_002945.3	Mycobrowser_v4	CDS	2893812	2894432	.	+	0	Mb2628	Mb2628		PROBABLE MEMBRANE PROTEIN	Mb2628, -, len: 206 aa. Equivalent to Rv2597, len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 206 aa overlap). Probable membrane protein.	X2BKW7,P65030,P65030	No	cell wall and cell processes			P65030					X2BKW7,P65030					Rv2597		Rv2597			
NC_002945.3	Mycobrowser_v4	CDS	567795	568241	.	+	0	Mb0487	Mb0487		POSSIBLE CONSERVED SECRETED PROTEIN	Mb0487, -, len: 148 aa. Equivalent to Rv0477, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 148 aa overlap). Possible conserved secreted protein, equivalent to CAC31969.1|AL583925 hypothetical protein from Mycobacterium leprae (123 aa). Also similar to G83406|PA1914 conserved hypothetical protein from Pseudomonas aeruginosa (408 aa). Contains possible N-terminal signal sequence.	X2BF58,P64698	No	cell wall and cell processes			P64698					X2BF58					Rv0477		Rv0477			
NC_002945.3	Mycobrowser_v4	CDS	171405	172358	.	+	0	Mb0150	Mb0150		possible s-adenosylmethionine-dependent methyltransferase	Mb0150, -, len: 317 aa. Equivalent to Rv0145, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Conserved hypothetical protein, highly similar to many e.g. CAC32172.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (310 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc.	X2BE73,Q7U2R3,Q7U2R3	No	lipid metabolism			Q7U2R3					X2BE73,Q7U2R3					Rv0145		Rv0145			
NC_002945.3	Mycobrowser_v4	CDS	611339	612034	.	+	0	Mb0531	Mb0531		POSSIBLE EXPORTED PROTEIN	Mb0531, -, len: 231 aa. Equivalent to Rv0518, len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible exported protein; has hydrophobic N-terminus.	Q7U1V5,A0A1R3XVK2	No	cell wall and cell processes			A0A1R3XVK2				IPR013831	Q7U1V5					Rv0518		Rv0518			
NC_002945.3	Mycobrowser_v4	CDS	3395619	3396095	.	+	0	Mb3103	Mb3103		CONSERVED HYPOTHETICAL PROTEIN	Mb3103, -, len: 158 aa. Equivalent to Rv3076, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, weakly similar to Q9AK12|SC8D11.07 HYPOTHETICAL 17.0 KDA PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 110, E(): 1.5, (25.5% identity in 145 aa overlap).	Q7TXB3	No	conserved hypotheticals							IPR019587,IPR023393	Q7TXB3	A0A1R3Y3F1				Rv3076		Rv3076			
NC_002945.3	Mycobrowser_v4	CDS	1265685	1265927	.	+	0	Mb1167	Mb1167		POSSIBLE ACETYL-COA ACETYLTRANSFERASE (ACETOACETYL-COA THIOLASE)	Mb1167, -, len: 80 aa. Equivalent to Rv1135A, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 80 aa overlap). Possible acetyl-CoA acetyltransferase (EC 2.3.1.9) (possible gene fragment),highly similar to other acetyl-CoA acetyltransferases e.g. C-terminal part of Rv3556c|Z92774|MTCY6G11_2|MTCY06G11.03|fadA6 ACETYL-COA ACETYLTRANSFERASE from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 219, E(): 5.7e-09, (63.6% identity in 55 aa overlap).	Q7U0K4,A0A1R3XXG1	No	lipid metabolism			A0A1R3XXG1				IPR002155,IPR016038,IPR016039,IPR020617	Q7U0K4					Rv1135A		Rv1135A			
NC_002945.3	Mycobrowser_v4	CDS	32041	33138	.	+	0	Mb0030	Mb0030		CONSERVED HYPOTHETICAL PROTEIN	Mb0030, -, len: 365 aa. Equivalent to Rv0029, len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 365 aa overlap). Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. C-terminal region of Rv2082|MTCY49_21|E247006 hypothetical 73.6 kDa protein (721 aa), FASTA scores: opt: 453, E(): 1.2e-22, (38.5% identity in 265 aa overlap); Rv3899c|MTY15F10_12 HYPOTHETICAL 40.8 KD PROTEIN (410 aa), FASTA score: (33.7% identity in 252 aa overlap); etc.	Q7U2Z7,A0A1R3XU96	No	conserved hypotheticals			A0A1R3XU96					Q7U2Z7					Rv0029		Rv0029			
NC_002945.3	Mycobrowser_v4	CDS	2043388	2043744	.	+	0	Mb1840	Mb1840		conserved protein	Mb1840, -, len: 118 aa. Equivalent to Rv1810, len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (possible N-terminal signal sequence) e.g. O53953|Rv1804c|MTV049.26c|AL022021 (108 aa), FASTA scores: opt: 361, E(): 9.6e-17, (53.5% identity in 101 aa overlap); Rv0622, and Rv1690, etc.	Q7TZH5,A0A1R3Y1J6	No	conserved hypotheticals			A0A1R3Y1J6				IPR007969	Q7TZH5					Rv1810		Rv1810			
NC_002945.3	Mycobrowser_v4	CDS	84031	85203	.	+	0	Mb0077	Mb0077		PROBABLE AMINOTRANSFERASE	Mb0077, -, len: 390 aa. Equivalent to Rv0075, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Probable aminotransferase (EC 2.6.1.-), similar to many CLASS-II PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES (MALY/PATB SUBFAMILY) e.g. NP_302217.1|NC_002677 aminotransferase from Mycobacterium leprae (402 aa); PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa), FASTA scores: opt: 684, E(): 5.4e-33, (31.3% identity in 384 aa overlap); etc. Also similar to several cystathionine beta-lyase (beta C-S lyase) e.g. AAK69425.1|AF276227_1|AF276227 from Corynebacterium glutamicum (368 aa); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv2294, Rv0858c,etc.	Q7U2W8,A0A1R3XWE7	No	intermediary metabolism and respiration			A0A1R3XWE7				IPR004839,IPR015421,IPR015422,IPR015424	Q7U2W8					Rv0075		Rv0075			
NC_002945.3	Mycobrowser_v4	CDS	222063	222353	.	+	0	Mb0196	Mb0196		conserved protein	Mb0196, -, len: 96 aa. Equivalent to Rv0190, len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Conserved hypothetical protein, highly similar to several hypothetical proteins e.g. SYCSLRA_35|Q55554|SLL0176 hypothetical 18.9 KD protein from Synechocystis (167 aa), FASTA scores: opt: 237, E(): 5.8e-16, (39.4% identity in 94 aa overlap). Also highly similar to Z95398|MLCL622_7|O06070 from Mycobacterium leprae (135 aa), FASTA score: (82.6% identity in 92 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0967,Rv0030, Rv1766 (42.5% identity in 80 aa overlap).	Q7U2M0,A0A1R3XUL8	No	conserved hypotheticals			A0A1R3XUL8				IPR003735	Q7U2M0					Rv0190		Rv0190			
NC_002945.3	Mycobrowser_v4	tRNA	732730	732802	.	+	0	thrT	thrT		tRNA-Thr	thrT, len: 73 nt. Equivalent to thrT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Thr, anticodon ggt.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	852832	852903	.	-	0	thrV	thrV		tRNA-Thr	thrV, len: 72 nt. Equivalent to thrV, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Thr, anticodon tgt.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1372164	1372721	.	+	0	Mb1260	lpqX		probable lipoprotein lpqx	Mb1260, lpqX, len: 185 aa. Equivalent to Rv1228,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 185 aa overlap). Probable lipoprotein LpqX. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U0C3,A0A1R3XXR3	No	cell wall and cell processes			A0A1R3XXR3					Q7U0C3					Rv1228		Rv1228			
NC_002945.3	Mycobrowser_v4	CDS	945098	945490	.	+	0	Mb0870	lpqS		PROBABLE LIPOPROTEIN LPQS	Mb0870, lpqS, len: 130 aa. Equivalent to Rv0847,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 130 aa overlap). Probable lpqS,lipoprotein. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U146,A0A1R3XWL6	No	cell wall and cell processes			A0A1R3XWL6					Q7U146					Rv0847		Rv0847			
NC_002945.3	Mycobrowser_v4	CDS	1737503	1739446	.	+	0	Mb1576	fadD11		probable fatty-acid-coa ligase fadd11 (fatty-acid-coa synthetase) (fatty-acid-coa synthase)	Mb1576, fadD11, len: 647 aa. Equivalent to Rv1549 (fadD11') and Rv1550 (fadD11), len: 175 aa and 571 aa,from Mycobacterium tuberculosis strain H37Rv, (100% identity in 167 aa overlap and 99.8% identity in 470 aa overlap). Possible fadD11', fatty-acid-CoA synthetase (EC 6.2.1.-), similar to the N-terminus of many fatty-acid CoA synthetases e.g. NP_147860.1|NC_000854 long-chain-fatty-acid--CoA ligase from Aeropyrum pernix (651 aa); P31685|4CL2_SOLTU 4-coumarate--CoA ligase 2 (EC 6.2.1.12) from Solanum tuberosum (Potato) (545 aa), FASTA scores: opt: 168, E(): 4.4e-06, (30.4% identity in 112 aa overlap); etc. Possible frameshift with respect to next ORF Rv1550|MTCY48.15c but we can find no sequence error to account for this. Probable fadD11, fatty-acid-CoA synthetase (EC 6.2.1.-), similar, except in N-terminus, to many e.g. SC6A5.39|T35430 probable long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) from Streptomyces coelicolor (612 aa); NP_301672.1|NC_002677 putative long-chain-fatty-acid-CoA ligase from Mycobacterium leprae (600 aa); P44446|LCFH_HAEIN putative long-chain-fatty-acid-CoA ligase from Haemophilus influenzae (607 aa), FASTA scores: opt: 762, E(): 2.3e-38,(34.4% identity in 436 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis, a two single base insertions (*-c and *-c) lead to a single product.	Q7TZX2,A0A1R3XYM2	No	lipid metabolism			A0A1R3XYM2				IPR000873,IPR020845	Q7TZX2					Rv1549		Rv1549			
NC_002945.3	Mycobrowser_v4	tRNA	1931953	1932026	.	+	0	proT	proT		tRNA-Pro	proT, len: 74 nt. Equivalent to proT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro, anticodon ggg.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2954688	2956604	.	-	0	Mb2701c	dxs1		PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS)	Mb2701c, dxs1, len: 638 aa. Equivalent to Rv2682c,len: 638 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 638 aa overlap). Probable dxs1,1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-),equivalent to Q50000|DXS_MYCLE|TKTB|ML1038 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE from Mycobacterium leprae (643 aa), FASTA scores: opt: 3635, E(): 5.6e-209,(86.4% identity in 632 aa overlap). Also highly similar to other Q9X7W3|DXS_STRCO|DXS|SC6A5.17 from Streptomyces coelicolor (656 aa), FASTA scores: opt: 2501, E(): 2e-141,(61.3% identity in 623 aa overlap); Q9K971|DXS_BACHD|DXS|BH2779 from Bacillus halodurans (629 aa), FASTA scores: opt: 1612, E(): 1.8e-88, (41.35% identity in 619 aa overlap); P77488|DXS_ECOLI|DXS|B0420 from Escherichia coli strain K12 (619 aa), FASTA scores: opt: 1511, E(): 1.8e-82, (39.5% identity in 625 aa overlap); etc. Also similar to O50408|Rv3379c|MTV004.37c from Mycobacterium tuberculosis (536 aa). BELONGS TO THE TRANSKETOLASE FAMILY. DXS SUBFAMILY. COFACTOR: THIAMINE PYROPHOSPHATE. Note that previously known as dxs.	X2BLJ2,P0A555,P0A555	No				P0A555					X2BLJ2,P0A555										
NC_002945.3	Mycobrowser_v4	CDS	3134338	3134601	.	+	0	Mb2891	relg		toxin relg	Mb2891, -, len: 87 aa. Equivalent to Rv2866, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Conserved hypothetical protein, similar to O50461|Rv1246c|MTV006.18c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 aa), FASTA scores: opt: 290, E(): 3.6e-16, (54.1% identity in 85 aa overlap).	Q7TXN8,A0A1R3Y2E5	No	virulence, detoxification, adaptation			A0A1R3Y2E5				IPR007712	Q7TXN8					Rv2866		Rv2866			
NC_002945.3	Mycobrowser_v4	CDS	3332373	3333002	.	+	0	Mb3041	lpqA		PROBABLE LIPOPROTEIN LPQA	Mb3041, lpqA, len: 209 aa. Equivalent to Rv3016,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable lpqA,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TXF9,A0A1R3Y4S9	No	cell wall and cell processes			A0A1R3Y4S9				IPR026954	Q7TXF9					Rv3016		Rv3016			
NC_002945.3	Mycobrowser_v4	CDS	3334888	3334974	.	-	0	Mb3044c	PE27A		pe family protein pe27a	Mb3044c, PE27A, len: 28 aa. Equivalent to Rv3018A,len: 28 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 28 aa overlap). Member of M. tuberculosis PE family, most similar to Rv0285 (102 aa),FASTA scores: opt: 147, E(): 3.5e-05, (92.85% identity in 28 aa overlap); etc.	Q7VEL4,A0A1R3Y399	No				A0A1R3Y399					Q7VEL4										
NC_002945.3	Mycobrowser_v4	tRNA	3388387	3388459	.	-	0	alaU	alaU		tRNA-Ala	alaU, len: 73 nt. Equivalent to alaU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon ggc.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	4063888	4063961	.	+	0	proY	proY		tRNA-Pro	proY, len: 74 nt. Equivalent to proY, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro, anticodon cgg.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	4158876	4158962	.	-	0	serU	serU		tRNA-Ser	serU, len: 87 nt. Equivalent to serU, len: 87 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 87 nt overlap). tRNA-Ser, anticodon tga.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1	1524	.	+	0	Mb0001	dnaA		CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA	Mb0001, dnaA, len: 507 aa. Equivalent to Rv0001,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 507 aa overlap). dnaA, chromosomal replication initiator protein (see citations below),equivalent to other Mycobacterial CHROMOSOMAL REPLICATION INITIATOR PROTEINS e.g. P46388|DNAA_MYCLE from Mycobacterium leprae (502 aa); Q9L7L7|DNAA_MYCPA from Mycobacterium paratuberculosis (509 aa); P49990|DNAA_MYCAV from Mycobacterium avium (508 aa); P49992|DNAA_MYCSM from Mycobacterium smegmatis (504 aa); etc. Also highly similar to others except in N-terminus e.g. Q9ZH75|DNAA_STRCH CHROMOSOMAL REPLICATION INITIATOR PROTEIN from Streptomyces chrysomallus (624 aa); Q9ZH76|DNAA_STRRE from Streptomyces reticuli (643 aa); DNAA_ECOLI|P03004|B3702 chromosomal replication initiator protein from Escherichia coli strain K12 (467 aa), FASTA scores: opt: 986, E(): 0,(43.2% identity in 389 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS01008 DnaA protein signature. BELONGS TO THE DNAA FAMILY. Note that the first base of this gene has been taken as base 1 of the Mycobacterium bovis genomic sequence.	X2BDR0,P49991,P49991	No	information pathways			P49991					X2BDR0,P49991					Rv0001		Rv0001			
NC_002945.3	Mycobrowser_v4	CDS	2052	3260	.	+	0	Mb0002	dnaN		DNA POLYMERASE III (BETA CHAIN) DNAN (DNA NUCLEOTIDYLTRANSFERASE)	Mb0002, dnaN, len: 402 aa. Equivalent to Rv0002,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 402 aa overlap). dnaN, DNA polymerase III (beta chain) (EC 2.7.7.7) (see citations below),equivalent to other Mycobacterial DNA POLYMERASES III BETA CHAIN e.g. NP_301130.1|NC_002677 from Mycobacterium leprae (399 aa); Q9L7L6|DP3B_MYCPA from Mycobacterium avium subsp. paratuberculosis (399 aa); P52851|DP3B_MYCSM from Mycobacterium smegmatis (397 aa); etc. Also highly similar to others e.g. P27903|DP3B_STRCO DNA POLYMERASE III BETA CHAIN from Streptomyces coelicolor (376 aa), FASTA scores: opt: 1189, E(): 0, (52.8% identity in 337 aa overlap); P21174|DP3B_MICLU from Micrococcus luteus (310 aa); P52023|DP3B_SYNP7 from Synechococcus sp. strain PCC 7942 (375 aa); etc. Overlaps and extends CDS in neighbouring cosmid MTCY10H4.01.	X2BDQ9,O33914,O33914	No	information pathways			O33914					X2BDQ9,O33914					Rv0002		Rv0002			
NC_002945.3	Mycobrowser_v4	CDS	5123	7267	.	+	0	Mb0005	gyrB		DNA GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE)	Mb0005, gyrB, len: 714 aa. Equivalent to Rv0005,len: 714 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 714 aa overlap). gyrB, DNA gyrase subunit B (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT B e.g. T10005 from Mycobacterium leprae (697 aa); Q9L7L3|GYRB_MYCPA from Mycobacterium avium subsp. paratuberculosis (677 aa) (has its N-terminus shorter); P48355|GYRB_MYCSM from Mycobacterium smegmatis (675 aa); etc. Also highly similar to others e.g. T10969 from Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH from Streptomyces spheroides (684 aa); etc. Contains PS00177 DNA topoisomerase II signature. BELONGS TO THE TYPE II TOPOISOMERASE FAMILY.	Q7U312,A0A1R3XU15	No	information pathways			A0A1R3XU15				IPR001241,IPR002288,IPR003594,IPR006171,IPR011557,IPR013506,IPR013759,IPR013760,IPR014721,IPR018522,IPR020568	Q7U312					Rv0005		Rv0005			
NC_002945.3	Mycobrowser_v4	tRNA	4153159	4153231	.	-	0	argU	argU		tRNA-Arg	argU, len: 73 nt. Equivalent to argU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon acg.		No																			
NC_002945.3	Mycobrowser_v4	CDS	7302	9818	.	+	0	Mb0006	gyrA		DNA GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE)	Mb0006, gyrA, len: 838 aa. Equivalent to Rv0006,len: 838 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 838 aa overlap). gyrA, DNA gyrase subunit A (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from Mycobacterium leprae (1273 aa); P48354|GYRA_MYCSM from Mycobacterium smegmatis (842 aa); etc. Also highly similar to others e.g. P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from Streptomyces coelicolor (864 aa); NP_346654.1|NC_003030 from Clostridium acetobutylicum (830 aa); NP_387888.1|NC_000964 from Bacillus subtilis (821 aa); etc. Contains PS00018 EF-hand calcium-binding domain.	Q7U311,A0A1R3XU07	No	information pathways			A0A1R3XU07				IPR002205,IPR005743,IPR006691,IPR013758,IPR013760,IPR024946	Q7U311					Rv0006		Rv0006			
NC_002945.3	Mycobrowser_v4	CDS	4186173	4187300	.	+	0	Mb3825	Mb3825		conserved protein	Mb3825, -, len: 375 aa. Equivalent to Rv3796, len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 375 aa overlap). Conserved hypothetical protein. C-terminal end similar in part to Q983J3|MLR8305 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (227 aa), FASTA scores: opt: 288, E(): 4e-09,(38.95% identity in 154 aa overlap). Similar to P54548|YQJK_BACSU HYPOTHETICAL PROTEIN (BELONGS TO THE ATSA/ELAC FAMILY) from Bacillus subtilis (307 aa) FASTA scores: opt: 263, E(): 1.3e-07, (26.1% identity in 295 aa overlap); and some similarity to other proteins e.g. AAK46775|MT2479 PUTATIVE ARYLSULFATASE from Mycobacterium tuberculosis strain CDC1551 (224 aa), FASTA scores: opt: 194, E(): 0.00072, (25.85% identity in 259 aa overlap). Equivalent to AAK48269 from Mycobacterium tuberculosis strain CDC1551 (338 aa) but longer 37 aa. SOME SIMILARITY TO THE A. CARRAGEENOVORA ATSA	Q7TVN2	No	conserved hypotheticals							IPR001279	Q7TVN2	A0A1R3Y5A9				Rv3796		Rv3796			
NC_002945.3	Mycobrowser_v4	tRNA	10887	10960	.	+	0	ileT	ileT		tRNA-Ile	ileT, len: 74 nt. Equivalent to ileT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Ile, anticodon gat.		No																			
NC_002945.3	Mycobrowser_v4	CDS	17466	18761	.	-	0	Mb0015c	pknA		TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE A PKNA (PROTEIN KINASE A) (STPK A)	Mb0015c, pknA, len: 431 aa. Equivalent to Rv0015c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). pknA, transmembrane serine/threonine-protein kinase (EC 2.7.1.-),magnesium/manganese dependent (see citations below),equivalent to MLCB1770_10|NP_301143.1|NC_002677 putative serine/threonine protein kinase from Mycobacterium leprae (437 aa), FASTA scores: opt: 1883, E(): 0, (72.1% identity in 434 aa overlap). And also highly similar to other kinases from Mycobacterium leprae e.g. MLCB1770_10 from Mycobacterium leprae (437 aa). Also similar to PKNA_MYCLE protein kinase (253 aa), FASTA scores: opt: 1525, E(): 0,(95.0% identity in 242 aa overlap); etc. Also highly similar in part to others e.g. N-terminus of NP_243370.1|NC_002570 from Bacillus halodurans (664 aa); N-terminus of T36717 from Streptomyces coelicolor (673 aa); etc. Also similar to others from Mycobacterium tuberculosis: MTCY10H4_15, MTV021_9, MTCY28_5,MTCY4C12_28, MTCY50_16, MTCY8D9_8, MTCY49_28, MTCY4C12_30,MTCY28_9, etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. It has been shown that sodium orthovanadate inhibits the activity of the enzyme in vitro.	X2BDS0,P65727,P65727	No				P65727					X2BDS0,P65727										
NC_002945.3	Mycobrowser_v4	CDS	12468	13016	.	+	0	Mb0009	ppiA		PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A)	Mb0009, ppiA, len: 182 aa. Equivalent to Rv0009,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable ppiA (alternate gene name: cfp22), iron-regulated peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8),equivalent to NP_301138.1|NC_002677 putative peptidyl-prolyl cis-trans isomerase from Mycobacterium leprae (182 aa), FASTA score: (90.1% identity in 182 aa overlap). Also highly similar to others e.g. T36725 from Streptomyces coelicolor (177 aa); T43805 from Halobacterium salinarum (180 aa); NP_219383.1|NC_000919 from Treponema pallidum (215 aa); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY. Alternative start codon has been suggested.	X2BDS2,P65763,P65763	No	information pathways			P65763					X2BDS2,P65763					Rv0009		Rv0009			
NC_002945.3	Mycobrowser_v4	CDS	58182	58472	.	+	0	Mb0054	rpsF		30s ribosomal protein s6 rpsf	Mb0054, rpsF, len: 96 aa. Equivalent to Rv0053,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). Probable 30S ribosomal protein S6, equivalent to RS6_MYCLE|P46389 30s ribosomal protein s6 from Mycobacterium leprae (96 aa), FASTA scores: opt: 570, E(): 1.1e-36, (91.7% identity in 96 aa overlap).Also highly similar to many e.g. Q9X8U2|RS6_STRCO 30S RIBOSOMAL PROTEIN S6 from Streptomyces coelicolor (96 aa); etc. Note that the putative product of this CDS corresponds to spot 6_26 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). Contains PS01048 Ribosomal protein S6 signature. BELONGS TO THE S6P FAMILY OF RIBOSOMAL PROTEINS.	X2BDX0,P66592,P66592	No	information pathways			P66592					X2BDX0,P66592					Rv0053		Rv0053			
NC_002945.3	Mycobrowser_v4	CDS	59399	59857	.	+	0	Mb0057	rplI		50s ribosomal protein l9 rpli	Mb0057, rplI, len: 152 aa. Equivalent to Rv0056,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). Probable rplI, 50S ribosomal protein L9, equivalent to RL9_MYCLE|P46385 50s ribosomal protein l9 from Mycobacterium leprae (152 aa),FASTA scores: opt: 847, E(): 0, (88.7% identity in 150 aa overlap). Also highly similar to others e.g. Q9X8U5|RL9_STRCO 50S RIBOSOMAL PROTEIN L9 from Streptomyces coelicolor (148 aa); etc. Contains PS00651 Ribosomal protein L9 signature. BELONGS TO THE L9P FAMILY OF RIBOSOMAL PROTEINS.	X2BDW5,P66316,P66316	No	information pathways			P66316					X2BDW5,P66316					Rv0056		Rv0056			
NC_002945.3	Mycobrowser_v4	CDS	14913	15611	.	+	0	Mb0013	trpG		POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)	Mb0013, trpG, len: 232 aa. Equivalent to Rv0013,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 232 aa overlap). Possible trpG,anthranilate synthase component II (glutamine amidotransferase) (EC 4.1.3.27), equivalent to NP_301141.1|NC_002677 putative p-aminobenzoate synthase glutamine amidotransferase from Mycobacterium leprae (232 aa). Also highly similar to others e.g. P26922|TRPG_AZOBR Anthranilate synthase component II from Azospirillum brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40,(56.7% identity in 187 aa overlap); T36720 probable glutamine amidotransferase from Streptomyces coelicolor (212 aa); T44524 anthranilate synthase from Nitrosomonas europaea (199 aa); etc. Also similar to E235740 para-aminobenzoate synthase (232 aa), FASTA scores: opt: 1273, E(): 0, (79.7% identity in 232 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site; and PS00442 Glutamine amidotransferases class-I active site. SIMILARITY TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAINS. Note that previously known as pabA.	Q7U307,A0A1R3XU22	No	intermediary metabolism and respiration			A0A1R3XU22				IPR006221,IPR017926	Q7U307					Rv0013		Rv0013			
NC_002945.3	Mycobrowser_v4	CDS	15589	17469	.	-	0	Mb0014c	pknB		TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B PKNB (PROTEIN KINASE B) (STPK B)	Mb0014c, pknB, len: 626 aa. Equivalent to Rv0014c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 626 aa overlap). pknB, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to MLCB1770_9|T10009 probable serine/threonine-specific protein kinase from Mycobacterium leprae (622 aa), FASTA scores: opt: 3600,E(): 0, (86.4% identity in 626 aa overlap). Also similar (highly similar in N-terminus) to others e.g. T36717 from Streptomyces coelicolor (673 aa); NP_389459.1|NC_000964 from Bacillus subtilis (648 aa); NP_465345.1|NC_003210 from Listeria monocytogenes (655 aa); E235741 protein kinase pknB (315 aa), FASTA scores: opt: 1839, E(): 0,(90.8 identity in 305 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature, and PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on serine/threonine residues.	X2BDS6,P0A5S5,P0A5S5	No				P0A5S5					X2BDS6,P0A5S5										
NC_002945.3	Mycobrowser_v4	CDS	4344746	4344889	.	-	0	Mb3955c	rpmH		50S RIBOSOMAL PROTEIN L34 RPMH	Mb3955c, rpmH, len: 47 aa. Equivalent to Rv3924c,len: 47 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 47 aa overlap). rpmH, 50s ribosomal protein l34 (see citations below), equivalent to many mycobacterial 50S RIBOSOMAL PROTEIN L34 e.g. P46386|RL34_MYCLE|RPMH|ML2713 from Mycobacterium leprae (47 aa), FASTA scores: opt: 287, E(): 8.5e-17, (91.5% identity in 47 aa overlap); and Q9L7L8|RL34_MYCPA|RPMH from M. paratuberculosis (47 aa), FASTA scores: opt: 281,E(): 2.6e-16, (89.35% identity in 47 aa overlap). Also highly similar to other ribosomal proteins e.g. P27901|RL34_STRCO|RPMH|STH24.02 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 234, E(): 1.4e-12,(79.05% identity in 43 aa overlap); and P05647|RL34_BACSU|RPMH from Bacillus subtilis (44 aa) FASTA scores: opt: 229, E(): 3.7e-12, (72.35% identity in 47 aa overlap); etc. Contains PS00784 Ribosomal protein L34 signature. BELONGS TO THE L34P FAMILY OF RIBOSOMAL PROTEINS.	X2BPR0,P0A5W5,P0A5W5	No				P0A5W5					X2BPR0,P0A5W5										
NC_002945.3	Mycobrowser_v4	CDS	18758	20233	.	-	0	Mb0016c	pbpA		PROBABLE PENICILLIN-BINDING PROTEIN PBPA	Mb0016c, pbpA, len: 491 aa. Equivalent to Rv0016c,len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 491 aa overlap). Probable pbpA,penicillin-binding protein, equivalent to NP_301144.1|NC_002677 putative penicillin-binding protein from Mycobacterium leprae (492 aa); and highly similar to MLCB1770_1 penicillin binding protein from Mycobacterium leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4% identity in 472 aa overlap). Also similar to others e.g. T36716 from Streptomyces coelicolor (490 aa); AAF61246.1|AF241575|PbpA from Streptomyces griseus (485 aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum (482 aa); E235825|pbpA penicillin binding protein (325 aa), FASTA scores: opt: 1618, E(): 0, (78.3% identity in 323 aa overlap); etc. And also similar to MTCY270_5 and MTV003_8 from Mycobacterium tuberculosis.	Q7U306,A0A1R3XU21	No				A0A1R3XU21				IPR001460,IPR012338	Q7U306										
NC_002945.3	Mycobrowser_v4	CDS	20230	21639	.	-	0	Mb0017c	rodA		PROBABLE CELL DIVISION PROTEIN RODA	Mb0017c, rodA, len: 469 aa. Equivalent to Rv0017c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein, equivalent to MLCB1770_12|T10012 probable cell division protein from Mycobacterium leprae (465 aa), FASTA scores: opt: 2475,E(): 0, (81.9% identity in 469 aa overlap). Also highly similar to others e.g. T36715|SCH69.16 from Streptomyces coelicolor (479 aa); NP_243432.1|NC_002570 from Bacillus halodurans (366 aa); NP_347145.1|NC_003030 from Clostridium acetobutylicum (400 aa); etc. Also similar to MTCY270_14 from Mycobacterium tuberculosis FASTA score: (32.2% identity in 369 aa overlap). BELONGS TO THE FTSW/RODA/SPOVE FAMILY.	X2BDS4,P63761,P63761	No				P63761					X2BDS4,P63761										
NC_002945.3	Mycobrowser_v4	CDS	2091231	2091857	.	+	0	Mb1884	ureD		Probable urease accessory protein ureD	Mb1884, ureD, len: 208 aa. Equivalent to Rv1853,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). ureD, probable urease accessory protein. Similar to URED_YEREN|P42868 Urease operon ureD protein from Yersinia enterocolitica (325 aa),Fasta scores: opt: 114, E(): 0.37, (25.2% identity in 119 aa overlap).	Q7VET5,A0A1R3XZI1	No	intermediary metabolism and respiration			A0A1R3XZI1				IPR002669	Q7VET5					Rv1853		Rv1853			
NC_002945.3	Mycobrowser_v4	CDS	21636	23180	.	-	0	Mb0018c	pstp		phosphoserine/threonine phosphatase pstp	Mb0018c, ppp, len: 514 aa. Equivalent to Rv0018c,len: 514 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 514 aa overlap). Possible ppp,serine/threonine phosphatase (EC 3.1.3.16), equivalent to MLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASE from Mycobacterium leprae (509 aa), FASTA scores: opt: 2517, E(): 0. Also highly similar to others e.g. T36714 probable protein phosphatase from Streptomyces coelicolor (515 aa); CAA10712.1|AJ132604 pppL protein from Lactococcus lactis (258 aa); NP_248765.1|NC_002516 probable phosphoprotein phosphatase from Pseudomonas aeruginosa (242 aa); etc. Also similar to BSUB0009_46 YLOO PROTEIN from Bacillus subtilis (254 aa), FASTA score: (34.0% identity in 250 aa overlap).	Q7U305,A0A1R3XV75	No				A0A1R3XV75				IPR001932,IPR015655	Q7U305										
NC_002945.3	Mycobrowser_v4	CDS	23269	23736	.	-	0	Mb0019c	fhab		conserved protein with fha domain, fhab	Mb0019c, -, len: 155 aa. Equivalent to Rv0019c,len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 155 aa overlap). Conserved hypothetical protein, equivalent to MLCB1770_14|NP_301147.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (155 aa), FASTA scores: opt: 902, E(): 0, (91.0% identity in 155 aa overlap). Also highly similar to T36713|AL079308|SCH69_14 from Streptomyces coelicolor (172 aa), FASTA scores: opt: 389,E(): 6e-21, (46.2% identity in 171 aa overlap); and similar in C-terminus to others e.g. NP_342559.1|NC_002754 Conserved hypothetical protein from Sulfolobus solfataricus (209 aa); etc. C-terminus also highly similar to C-terminal part of AAF07901.1|AF173844_2|AF173844 putative signal transduction protein GarA from Mycobacterium smegmatis (158 aa). Also similar to Rv1827|MTCY 1A11.16c from Mycobacterium tuberculosis ( 162 aa), FASTA score: (41.2% identity in 85 aa overlap); MTMOAIS_3; MAU66560_1 and MLCB1788_15.	Q7U304,A0A1R3XU87	No	regulatory proteins			A0A1R3XU87				IPR000253,IPR008984	Q7U304					Rv0019c		Rv0019c			
NC_002945.3	Mycobrowser_v4	CDS	23860	25425	.	-	0	Mb0020c	fhaa		conserved protein with fha domain, fhaa	Mb0020c, TB39.8, len: 521 aa. Equivalent to Rv0020c, len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 527 aa overlap). TB39.8,conserved hypothetical protein, identified by proteomic study by the Statens Serum Institute, Denmark (spot TB39.8) (see citation below). Highly similar to NP_301148.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (488 aa); and Z70722|MLCB1770_15|T10015 hypothetical protein from Mycobacterium leprae (463 aa), FASTA scores: opt: 1213,E(): 2.2e-32, (72.3% identity in 506 aa overlap). Alternative start codon in position 24979 has been suggested. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 18 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (521 aa versus 527 aa).	Q7U303,A0A1R3XUP2	No	regulatory proteins			A0A1R3XUP2				IPR000253,IPR008984,IPR022128	Q7U303					Rv0020c		Rv0020c			
NC_002945.3	Mycobrowser_v4	CDS	36591	36854	.	+	0	Mb0034	acpA		PROBABLE ACYL CARRIER PROTEIN ACPA (ACP)	Mb0034, acpA, len: 87 aa. Equivalent to Rv0033,len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Probable acpA (alternate gene name: acpP), acyl carrier protein, similar to others e.g. ACP_BACSU|P80643 acyl carrier protein (acp) from Bacillus subtilis (77 aa), FASTA scores: opt: 149,E(): 0.00026, (41.4% identity in 70 aa overlap); NP_224500.1|NC_000922 Acyl Carrier Protein from Chlamydophila pneumoniae (79 aa); NP_228471.1|NC_000853 acyl carrier protein from Thermotoga maritima (81 aa); etc. Also similar to proteins of Mycobacterium tuberculosis Rv1344 and Rv2244 (31.5% identity in 73 aa overlap).	Q7U2Z4,A0A1R3XU46	No	lipid metabolism			A0A1R3XU46				IPR003231,IPR009081	Q7U2Z4					Rv0033		Rv0033			
NC_002945.3	Mycobrowser_v4	CDS	59112	59366	.	+	0	Mb0056	rpsR1		30s ribosomal protein s18-1 rpsr1	Mb0056, rpsR1, len: 84 aa. Equivalent to Rv0055,len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Probable rpsR1, 30S ribosomal protein S18-1, equivalent to NP_302711.1|NC_002677|O53125|RS18_MYCLE 30S RIBOSOMAL PROTEIN from Mycobacterium leprae (84 aa). Also highly similar to others e.g. Q9X8U4|R18A_STRCO 30S RIBOSOMAL PROTEIN S18-1 from Streptomyces coelicolor (78 aa); RS18_B|ACST|P10806 30s ribosomal protein s18 (bs21) (77 aa), FASTA scores: opt: 220, E(): 4e-10, (52.2% identity in 67 aa overlap); etc. Also similar to MTCY63A_5 from Mycobacterium tuberculosis. BELONGS TO THE S18P FAMILY OF RIBOSOMAL PROTEINS. Note that previously known as rpsR.	X2BDW2,P69231,P69231	No	information pathways			P69231					X2BDW2,P69231					Rv0055		Rv0055			
NC_002945.3	Mycobrowser_v4	CDS	34279	36594	.	+	0	Mb0033	bioF2		POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE)	Mb0033, bioF2, len: 771 aa. Equivalent to Rv0032,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 771 aa overlap). Probable bioF2,8-amino-7-oxononanoate synthase (EC 2.3.1.47), with its C-terminal similar to others e.g. BIOF_BACSU|P53556 8-amino-7-oxononanoate synthase from Bacillus subtilis (389 aa), FASTA scores: opt: 775, E(): 0, (37.9% identity in 346 aa overlap); P22806|BIOF_BACSH from Bacillus sphaericus (389 aa); etc. Also similar to BIOF1|Rv1569|MTCY336_35 from Mycobacterium tuberculosis (386 aa), AF041819_4 from Mycobacterium bovis, and BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.	Q7U2Z5,A0A1R3XU34	No				A0A1R3XU34				IPR001917,IPR004839,IPR015421,IPR015422,IPR015424,IPR016181	Q7U2Z5										
NC_002945.3	Mycobrowser_v4	CDS	37243	38931	.	+	0	Mb0036	fadD34		PROBABLE FATTY-ACID-COA LIGASE FADD34 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb0036, fadD34, len: 562 aa. Equivalent to Rv0035,len: 562 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 562 aa overlap). Probable fadD34,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. MBU75685_1 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 408, E(): 8.2e-20; etc. Also similar to G1171128 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa),FASTA scores: opt: 445, E(): 1.3e-21, (28.1% identity in 573 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. MTCY02B10.09, FASTA score: (32.3% identity in 468 aa overlap), MTCY349_40,MTCY4D9_17, MTCY338_18, MTV045_3, MTCY409_4, MTCI237_30,MTCY24G1_8, MASC_MYCLE MASC PROTEIN, U00010_6, MTV005_21,MTCY19G5_7, MTCY9F9_39, etc.	Q7U2Z3,A0A1R3XU59	No				A0A1R3XU59				IPR000873	Q7U2Z3										
NC_002945.3	Mycobrowser_v4	CDS	2275182	2275838	.	+	0	Mb2072	lppI		Probable lipoprotein lppI	Mb2072, lppI, len: 218 aa. Equivalent to Rv2046,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Probable lppI,lipoprotein contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7VES3,A0A1R3Y052	No	cell wall and cell processes			A0A1R3Y052					Q7VES3					Rv2046		Rv2046			
NC_002945.3	Mycobrowser_v4	CDS	42417	43349	.	-	0	Mb0041c	mtc28		SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE RICH 28 KDA ANTIGEN)	Mb0041c, mtc28, len: 310 aa. Equivalent to Rv0040c,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). mtc28, secreted proline rich 28 kDa antigen protein (has hydrophobic stretch at N-terminus) (see citation below). Highly similar to O33075|PR28_MYCLE|MT10019 Proline rich 28 kDa antigen from Mycobacterium leprae (278 aa), FASTA scores: opt: 1007, E(): 0, (65.0% identity in 257 aa overlap); and Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 putative lipoprotein from Mycobacterium leprae (218 aa). C-terminal part very similar to lipoprotein Rv1016c from Mycobacterium tuberculosis.	X2BDU6,P0A5Q7	No				P0A5Q7					X2BDU6										
NC_002945.3	Mycobrowser_v4	CDS	58576	59070	.	+	0	Mb0055	ssb		single-strand binding protein ssb (helix-destabilizing protein)	Mb0055, ssb, len: 164 aa. Equivalent to Rv0054,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 164 aa overlap). Probable ssb,single-strand binding protein, equivalent to highly similar to others e.g. SSB_MYCLE|P46390 single-strand binding protein from Mycobacterium leprae (140 aa), FASTA scores: opt: 792, E(): 0, (92.6% identity in 135 aa overlap); and AAK30583.1|AF349434 single-stranded DNA-binding protein from Mycobacterium smegmatis (165 aa). Also highly similar to others e.g. T36594 probable single-strand binding protein from Streptomyces coelicolor (199 aa); etc. Also similar to Rv2478c|MTV008_34c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (161 aa), FASTA score: E (): 1.1e-06. Note that the putative product of this CDS corresponds to spot 3_210 identified in culture supernatant by proteomics at the Max-Planck-Institut fuer Infektionsbiologie (see citations below). BELONGS TO THE SSB FAMILY.	X2BDW1,P0A611,P0A611	No	information pathways			P0A611					X2BDW1,P0A611					Rv0054		Rv0054			
NC_002945.3	Mycobrowser_v4	CDS	43546	46455	.	+	0	Mb0042	leuS		PROBABLE LEUCYL-tRNA SYNTHETASE LEUS (LEUCINE--tRNA LIGASE) (LEURS)	Mb0042, leuS, len: 969 aa. Equivalent to Rv0041,len: 969 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 969 aa overlap). Probable leucyl-tRNA synthetase (EC 6.1.1.4), equivalent to NP_301156.1|NC_002677|MLCB628_3 leucyl-tRNA synthase from Mycobacterium leprae (972 aa), FASTA score: (83.6% identity in 972 aa overlap); and highly similar to MLCB1770_20 from Mycobacterium leprae (824 aa), FASTA score: (82.8% identity in 824 aa overlap). Also highly similar to others e.g. CAB66249.1|AL136518 leucyl-tRNA synthetase from Streptomyces coelicolor (966 aa); NP_244147.1|NC_002570 leucyl-tRNA synthetase from Bacillus halodurans (806 aa); SYL_BACSU|P36430 leucyl-tRNA synthetase from Bacillus subtilis (804 aa), FASTA scores: opt: 714, E(): 3.1e-38, (43.7% identity in 938 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BDV0,P67511,P67511	No	information pathways			P67511					X2BDV0,P67511					Rv0041		Rv0041			
NC_002945.3	Mycobrowser_v4	CDS	137979	138551	.	+	0	Mb0118	gmhb		possible d-alpha,beta-d-heptose-1,7-biphosphate phosphatase gmhb (d-glycero-d-manno-heptose 7-phosphate kinase)	Mb0118, -, len: 190 aa. Equivalent to Rv0114, len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 190 aa overlap). Possible dehydratase (EC 4.-.-.-), similar to several hypothetical proteins and to HIS7_ECOLI|P06987 imidazoleglycerol-phosphate dehydratase (355 aa), FASTA scores: opt: 250, E(): 3.6e-11, (34.0 % identity in 141 aa overlap).	X2BE37,Q7U2U1,Q7U2U1	No	cell wall and cell processes			Q7U2U1					X2BE37,Q7U2U1					Rv0114		Rv0114			
NC_002945.3	Mycobrowser_v4	CDS	4344372	4344749	.	-	0	Mb3954c	rnpA		RIBONUCLEASE P PROTEIN COMPONENT RNPA (RNaseP PROTEIN) (RNase P PROTEIN) (PROTEIN C5)	Mb3954c, rnpA, len: 125 aa. Equivalent to Rv3923c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). rnpA, ribonuclease P protein component (EC 3.1.26.5) (see citations below),equivalent, but longer ~10 aa, to P46610|RNPA_MYCLE|ML2712 RIBONUCLEASE P PROTEIN COMPONENT from Mycobacterium leprae (120 aa), FASTA scores: opt: 456, E(): 3.3e-24, (63.0% identity in 119 aa overlap); and Q9L7L9|RNPA from Mycobacterium paratuberculosis (119 aa), FASTA scores: opt: 426, E(): 3.5e-22, (60.65% identity in 122 aa overlap). Also similar to many e.g. P25817|RNPA_STRBI from Streptomyces bikiniensis (123 aa), FASTA scores: opt: 174,E(): 4.2e-05, (36.8% identity in 125 aa overlap); P25814|RNPA_BACSU from Bacillus subtilis (116 aa) FASTA scores: opt: 168, E(): 0.0001, (26.85% identity in 108 aa overlap); P48206|RNPA_STRCO|STH24.03 from Streptomyces coelicolor (123 aa), FASTA scores: opt: 166, E(): 0.00015,(37.6% identity in 125 aa overlap); etc. Contains PS00648 Bacterial Ribonuclease P protein component signature. BELONGS TO THE RNPA FAMILY.	X2BQ52,P0A5X9,P0A5X9	No				P0A5X9					X2BQ52,P0A5X9										
NC_002945.3	Mycobrowser_v4	CDS	50005	51108	.	-	0	Mb0047c	ino1		MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase)	Mb0047c, ino1, len: 367 aa. Equivalent to Rv0046c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 367 aa overlap). ino1 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below), equivalent to Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity in 366 aa overlap). N-terminus similar to N-terminus of myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 myo-inositol-1-phosphate synthase (510 aa), FASTA scores: opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); CAC21218.1|AJ401007 myo-inositol 1P synthase from Thermotoga sp. SG1 (335 aa); etc. Also highly similar to other hypothetical proteins e.g. AL049826|SCH24_21c hypothetical protein from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1790, E(): 0, (77.8% identity in 360 aa overlap); AE000881_1 conserved protein from M. thermoautotrophicus (368 aa); etc.	X2BDV5,P59967,P59967	No				P59967					X2BDV5,P59967										
NC_002945.3	Mycobrowser_v4	CDS	53221	55689	.	+	0	Mb0051	ponA1		PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)	Mb0051, ponA1, len: 822 aa. Equivalent to penicillin-binding protein, len: 822 aa, from Mycobacterium bovis strain AN5, (99% identity in 821 aa overlap), Equivalent to penicillin-binding protein from Mycobacterium bovis BCG strain Korea 1168P (99% identity in 821 aa overlap), penicillin-binding protein from Mycobacterium tuberculosis strain CDC1551 (99% identity in 817 aa overlap), bifunctional penicillin-binding protein 1A/1B ponA1: penicillin-insensitive transglycosylase + penicillin-sensitive transpeptidase from Mycobacterium tuberculosis strain F11 (99% identity with 819 aa overlap). Probable ponA1, penicillin-binding protein (class A), bienzymatic protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities,highly similar to many e.g. NP_302715.1|NC_002677 penicillin-binding protein from Mycobacterium leprae (708 aa); AAB53123.1|L39923 penicillin binding protein from Mycobacterium leprae (686 aa), FASTA scores: (82.3% identity in 679 aa overlap); Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 penicillin-binding protein 1 from Mycobacterium smegmatis (715 aa) (see citation below); CAB88838.1|AL353832 probable penicillin-binding protein from Streptomyces coelicolor (756 aa); etc. Also similar to ponA2|Rv3682|MTV025.030 BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B from Mycobacterium tuberculosis (810 aa). BELONGS TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION. UPDATE: 5' annotation extension based on de novo proteomics from Mycobacterium tuberculosis strain H37Rv under exponential conditions (See Schubert et al., 2013). Mb0051 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BDV7,A0A1R3XUS2	No				A0A1R3XUS2					X2BDV7										
NC_002945.3	Mycobrowser_v4	CDS	60386	63010	.	+	0	Mb0059	dnaB		PROBABLE REPLICATIVE DNA HELICASE DNAB	Mb0059, dnaB, len: 874 aa. Equivalent to Rv0058,len: 874 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 874 aa overlap). Probable dnaB,replicative DNA helicase (EC 3.6.1.-). Contains an intein (position 61630..62838) similar to, and in the same position as, those in Sycnechocystis and Rhodothermus marinus (see citation below). Highly similar to others e.g. DNAB_SYNY3|Q55418 replicative dna helicase (872 aa),FASTA scores: opt: 533, E(): 0, (32.5% identity in 424 aa overlap). Also similar to intein recA|E1173867|AL008967 RECA INTEIN from Mycobacterium tuberculosis (442 aa),FASTA scores: E(): 3.8e-16, (27.0% identity in 426 aa overlap). C-terminal extein (position 62839..63015) similar to many dnaB proteins e.g. NP_302709.1|NC_002677|P46394|DNAB_MYCLE REPLICATIVE DNA HELICASE from Mycobacterium leprae (604 aa); DNAB_ECOLI|P03005 replicative dna helicase from Escherichia coli (471 aa), FASTA scores: opt: 148, E(): 1.5e-07, (37.9% identity in 58 aa overlap); etc. THIS PROTEIN UNDERGOES A PROTEIN SELF SPLICING THAT INVOLVES A POST-TRANSLATIONAL EXCISION OF THE INTERVENING REGION (INTEIN) FOLLOWED BY PEPTIDE LIGATION. BELONGS TO THE HELICASE FAMILY, DNAB SUBFAMILY. IN THE INTEIN SECTION; BELONGS TO THE HOMING ENDONUCLEASE FAMILY.	X2BDX5,P59966,P59966	No	information pathways			P59966					X2BDX5,P59966					Rv0058		Rv0058			
NC_002945.3	Mycobrowser_v4	CDS	71616	71855	.	+	0	Mb0065A	vapB1		Possible antitoxin VapB1	Mb0065A, len: 79 aa. Equivalent to Rv0064A len: 79 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 79 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB1,antitoxin, part of toxin-antitoxin (TA) operon with Rv0065 (See Arcus et al., 2005; Pandey and Gerdes, 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv0300 (73 aa),Rv1721c (75 aa)	X2BDX1,A0A1R3XU88	No	virulence, detoxification, adaptation			A0A1R3XU88					X2BDX1					Rv0064A		Rv0064A			
NC_002945.3	Mycobrowser_v4	CDS	71848	72249	.	+	0	Mb0066	vapc1		possible toxin vapc1	Mb0066, -, len: 133 aa. Equivalent to Rv0065, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis: Rv0960 (127 aa),Rv1720c (129 aa), and Rv0549c (137 aa).	Q7U2X7,A0A1R3XU79	No	virulence, detoxification, adaptation			A0A1R3XU79				IPR002716,IPR022907	Q7U2X7					Rv0065		Rv0065			
NC_002945.3	Mycobrowser_v4	CDS	72301	74538	.	-	0	Mb0067c	icd2		PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP)	Mb0067c, icd2, len: 745 aa. Equivalent to Rv0066c,len: 745 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 745 aa overlap). Probable icd2,isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42),equivalent to NP_302705.1|NC_002677 isocitrate dehydrogenase [NADP] from Mycobacterium leprae (746 aa). Also highly similar to many members of the monomeric-type family of IDH e.g. NP_251314.1|NC_002516 isocitrate dehydrogenase from Pseudomonas aeruginosa (741 aa); IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106,E(): 0, (61.4% identity in 735 aa overlap); NP_230786.1|NC_002505 isocitrate dehydrogenase [Vibrio cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FAMILY OF IDH.	Q7U2X6,A0A1R3XWE0	No				A0A1R3XWE0				IPR004436,IPR024084	Q7U2X6										
NC_002945.3	Mycobrowser_v4	CDS	76264	77649	.	-	0	Mb0070c	sdaA		PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE DEAMINASE) (SDH) (L-SD)	Mb0070c, sdaA, len: 461 aa. Equivalent to Rv0069c,len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable sdaA,L-serine dehydratase (EC 4.3.1.17), equivalent to NP_302203.1| NC_002677 L-serine dehydratase from Mycobacterium leprae (458 aa). Also highly similar to many e.g. NP_251133.1|NC_002516 L-serine dehydratase from Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO L-SERINE DEHYDRATASE from Streptomyces coelicolor (455 aa); SDHL_ECOLI|P16095 L-serine dehydratase 1 from Escherichia coli (454 aa), FASTA scores: opt: 1381, E(): 0, (51.1% identity in 460 aa overlap); etc. BELONGS TO THE IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE).	X2BDX6,P66774,P66774	No				P66774					X2BDX6,P66774										
NC_002945.3	Mycobrowser_v4	CDS	77646	78923	.	-	0	Mb0071c	glyA2		serine hydroxymethyltransferase glya2 (serine methylase 2) (shmt 2)	Mb0071c, glyA2, len: 425 aa. Equivalent to Rv0070c,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Probable glyA2, serine hydroxymethyltransferase (EC 2.1.2.1), equivalent to NP_302318.1|NC_002677 serine hydroxymethyltransferase from Mycobacterium leprae (426 aa). Also highly similar to many e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE from Streptomyces coelicolor (420 aa); AAK60516.1|AF327063_1|AF327063 serine hydroxymethyltransferase from Corynebacterium glutamicum (434 aa); GLYA_ECOLI|P00477 serine hydroxymethyltransferase from Escherichia coli (417 aa),FASTA scores: opt: 1462, E(): 0, (54.3% identity in 416 aa overlap); etc. Also highly similar to MTV017_46 from Mycobacterium tuberculosis. Contains PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE.	X2BDX9,Q7U2X3,Q7U2X3	No				Q7U2X3					X2BDX9,Q7U2X3										
NC_002945.3	Mycobrowser_v4	CDS	92363	93313	.	+	0	Mb0087	hycD		POSSIBLE FORMATE HYDROGENLYASE HYCD (FHL)	Mb0087, hycD, len: 316 aa. Equivalent to Rv0084,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 316 aa overlap). Possible hycD (alternate gene name: hevD), formate hydrogenlyase (EC 1.-.-.-), integral membrane protein, similar to others e.g. HYCD_ECOLI|P16430 formate hydrogenlyase subunit 4 from Escherichia coli (307 aa), FASTA scores: opt: 570,E(): 2.1e-26, (33.8% identity in 305 aa overlap); AAK06856.1|AF335723_2|AF335723 formate hydrogenlyase subunit 4 from Burkholderia pseudomallei (316 aa); NP_457244.1|NC_003198 formate hydrogenlyase subunit 4 from Salmonella enterica subsp. enterica serovar Typhi (307 aa); etc. Also similar to NUOH_ECOLI|P33603 NADH dehydrogenase I chain H from Escherichia coli (325 aa),FASTA scores: opt: 207, E(): 9.5e-06, (26.5% identity in 260 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY.	Q7U2V8,A0A1R3XVE2	No	intermediary metabolism and respiration			A0A1R3XVE2				IPR001694	Q7U2V8					Rv0084		Rv0084			
NC_002945.3	Mycobrowser_v4	CDS	93324	93986	.	+	0	Mb0088	hycP		POSSIBLE HYDROGENASE HYCP	Mb0088, hycP, len: 220 aa. Equivalent to Rv0085,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Possible hycP,hydrogenase (EC 1.-.-.-), integral membrane protein,weakly similar to P77524|HYFE_ECOLI HYDROGENASE-4 COMPONENT E from Escherichia coli (216 aa), FASTA scores: opt: 204, E():1.2e-07, (25.5% identity in 216 aa overlap).	X2BDZ6,P64682,P64682	No	intermediary metabolism and respiration			P64682					X2BDZ6,P64682					Rv0085		Rv0085			
NC_002945.3	Mycobrowser_v4	CDS	93986	95452	.	+	0	Mb0089	hycQ		POSSIBLE HYDROGENASE HYCQ	Mb0089, hycQ, len: 488 aa. Equivalent to Rv0086,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Possible hycQ,hydrogenase (EC 1.-.-.-), integral membrane protein,weakly similar to P77437|HYFF_ECOLI HYDROGENASE-4 COMPONENT F from Escherichia coli (526 aa), FASTA scores: opt: 948, E(): 0, (35.9% identity in 493 aa overlap); and AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa). Also similar to d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L from Escherichia coli (613 aa), FASTA scores: opt: 360,E():3.2e-13, (27.9% identity in 488 aa overlap); and to NUON_ECOLI|P33608 NADH dehydrogenase I chain N from Escherichia coli (425 aa), FASTA scores: opt: 375, E(): 3.9e-14, (25.0% identity in 432 aa overlap).	Q7U2V7,A0A1R3XUW8	No	intermediary metabolism and respiration			A0A1R3XUW8				IPR001750	Q7U2V7					Rv0086		Rv0086			
NC_002945.3	Mycobrowser_v4	CDS	95449	96927	.	+	0	Mb0090	hycE		possible formate hydrogenase hyce (fhl)	Mb0090, hycE, len: 492 aa. Equivalent to Rv0087,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Possible hycE (alternate gene name: hevE), formate hydrogenlyase (EC 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate hydrogenlyase subunit 5 from Escherichia coli (569 aa),FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in 449 aa overlap); NP_457243.1|NC_003198 formate hydrogenlyase subunit 5 from Salmonella enterica subsp. enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 formate hydrogenlyase subunit 5 from Methanothermobacter thermautotrophicus (370 aa); etc. Also some similarity with NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from Escherichia coli (407 aa), FASTA scores: opt: 245, E(): 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO THE COMPLEX I 49 kDa SUBUNIT FAMILY.	Q7U2V6,A0A1R3XUA2	No	intermediary metabolism and respiration			A0A1R3XUA2				IPR001135,IPR001268,IPR001501,IPR020396	Q7U2V6					Rv0087		Rv0087			
NC_002945.3	Mycobrowser_v4	CDS	99719	100486	.	+	0	Mb0094	mtn		probable bifunctional mta/sah nucleosidase mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + s-adenosylhomocysteine nucleosidase (s-adenosyl-l-homocysteine homocysteinylribohydrolase)	Mb0094, mtn, len: 255 aa. Equivalent to Rv0091,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Probable mtn (alternate gene name: pfs), MTA/SAH nucleosidase,including 5'-methylthioadenosine nucleosidase (EC 3.2.2.16) and S-adenosylhomocysteine nucleosidase (EC 3.2.2.9), similar to others e.g. NP_521493.1|NC_003295 PROBABLE BIFUNCTIONAL PROTEIN (MTA/SAH NUCLEOSIDASE) (P46): 5'-METHYLTHIOADENOSINE NUCLEOSIDASE AND S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from Ralstonia solanacearum (261 aa); AAC45731.1|U55214 Pfs from Treponema pallidum (249 aa); P96122|MTN_TREPA MTA/SAH NUCLEOSIDASE from Treponema pallidum (269 aa); PFS_ECOLI|P24247 pfs protein (p46) from Escherichia coli (232 aa), FASTA scores: opt: 214, E(): 3.8e-08, (30.5% identity in 246 aa overlap); etc. BELONGS TO THE MTN FAMILY.	X2BE00,P67657,P67657	No	intermediary metabolism and respiration			P67657					X2BE00,P67657					Rv0091		Rv0091			
NC_002945.3	Mycobrowser_v4	CDS	100618	102903	.	+	0	Mb0095	ctpA		cation transporter p-type atpase a ctpa	Mb0095, ctpA, len: 761 aa. Equivalent to Rv0092,len: 761 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 761 aa overlap). Probable ctpA,cation-transporting P-type ATPase A (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. CTPA_MYCLE|P46839 cation-transporting P-type ATPase A from Mycobacterium leprae (780 aa), FASTA scores: opt: 3454,E(): 0, (74.4% identity in 741 aa overlap); CAB66270.1|AL136519 probable cation-transporting P-type ATPase from Streptomyces coelicolor (760 aa); NP_391230.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); etc. Also highly similar to MTCY251.22c from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain,and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES),SUBFAMILY IB.	Q7U2V5,A0A1R3XUB5	No	cell wall and cell processes			A0A1R3XUB5				IPR000579,IPR001757,IPR006121,IPR008250,IPR017969,IPR018303,IPR023214,IPR023299,IPR027256	Q7U2V5					Rv0092		Rv0092			
NC_002945.3	Mycobrowser_v4	CDS	105360	106751	.	+	0	Mb0099	PPE1		ppe family protein ppe1	Mb0099, PPE1, len: 463 aa. Equivalent to Rv0096,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 463 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. Z46257|MLACEA_3 aceA gene for isocitrate L from M. leprae (438 aa), FASTA scores: opt: 1207, E(): 0, (55.3% identity in 380 aa overlap). Also similar to Z97559|MTCY261_19 from Mycobacterium tuberculosis (473 aa), FASTA score: (40.2% identity in 478 aa overlap); YHS6_MYCTU|P42611 hypothetical 50.6 kd protein (517 aa),FASTA scores: opt: 365, E(): 4.6e-12, (37.6% identity in 178 aa overlap). Also similar to MTCY274.23c from M. tuberculosis FASTA score: (31.1% identity in 383 overlap). Some similarity also to MTCY31.06c and MTCY48.17 and other mycobacterial PPE family proteins.	Q7U2V1,A0A1R3XUX7	No	PE/PPE			A0A1R3XUX7				IPR000030	Q7U2V1					Rv0096		Rv0096			
NC_002945.3	Mycobrowser_v4	CDS	107636	108187	.	+	0	Mb0101	fcot		probable fatty acyl coa thioesterase type iii fcot	Mb0101, -, len: 183 aa. Equivalent to Rv0098, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, equivalent to CAC30948.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (183 aa). Also some similarity with BAB69378.1|AB070955 hypothetical protein from Streptomyces avermitilis (172 aa).	X2BE08,P64686	No	lipid metabolism			P64686					X2BE08					Rv0098		Rv0098			
NC_002945.3	Mycobrowser_v4	CDS	108192	109814	.	+	0	Mb0102	fadD10		POSSIBLE FATTY-ACID-COA LIGASE FADD10 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb0102, fadD10, len: 540 aa. Equivalent to Rv0099,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). Possible fadD10,fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to MLACEA_4|Q50176 LONG CHAIN FATTY ACID-COA LIGASE from Mycobacterium leprae (532 aa), FASTA scores: opt: 2580,E(): 0, (74.6% identity in 531 aa overlap). Also similar to many e.g. BAB69379.1|AB070955 long-chain fatty acid--CoA ligase from Streptomyces avermitilis (518 aa); NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (530 aa); NP_435326.1|NC_003037 probable long chain fatty acid CoA ligase from Sinorhizobium meliloti (508 aa); etc. Also similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase from Bacillus subtilis (572 aa), FASTA scores: opt: 415,E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains PS00455 putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7U2V0,A0A1R3XUC2	No				A0A1R3XUC2				IPR000873,IPR020845,IPR025110	Q7U2V0										
NC_002945.3	Mycobrowser_v4	CDS	161962	162345	.	+	0	Mb0139-1	ephf		possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase)	Mb0139-1, -, len: 128 aa. Pseudogene part1 of Rv0134/ephF		No																			
NC_002945.3	Mycobrowser_v4	CDS	162345	162452	.	+	0	Mb0139-2	ephf		possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase)	Mb0139-2, -, len: 36 aa. Pseudogene part2 of Rv0134/ephF		No																			
NC_002945.3	Mycobrowser_v4	CDS	110037	117575	.	+	0	Mb0104	nrp		PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE)	Mb0104, nrp, len: 2512 aa. Equivalent to Rv0101,len: 2512 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2512 aa overlap). Probable nrp,peptide synthetase (EC 6.-.-.-), similar to others e.g. AAD44234.1|AF143772_40|PstB peptide synthetase from Mycobacterium avium (2552 aa); 7476034|S77657 cyclic peptide synthetase from Mycobacterium leprae (1401 aa),FASTA scores: opt: 4268, E(): 0, (65.7% identity in 1091 aa overlap); part of CAB55600.1|AJ238027 peptide synthetase from Mycobacterium smegmatis (5990). Also similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF protein from Bacillus subtilis (2378 aa); SRF1_BACSU|P27206 surfactin synthetase subunit 1 (3587 aa), FASTA scores: opt: 1708, E(): 0, (30.6% identity in 1633 aa overlap): etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), 2 x PS00455 Putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. THOUGHT TO BE NOT INVOLVED IN MYCOBACTIN BIOSYNTHESIS (see citation below).	Q7U2U9,A0A1R3XUD7	No	lipid metabolism			A0A1R3XUD7				IPR000873,IPR001242,IPR006162,IPR009081,IPR010071,IPR010080,IPR013120,IPR016040,IPR020845,IPR025110	Q7U2U9					Rv0101		Rv0101			
NC_002945.3	Mycobrowser_v4	CDS	119951	122209	.	-	0	Mb0106c	ctpB		PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB	Mb0106c, ctpB, len: 752 aa. Equivalent to Rv0103c,len: 752 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 752 aa overlap). Probable ctpB,cation-transporting P-type ATPase B (transmembrane protein) (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 cation-transporting P-type ATPase B from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% identity in 752 aa overlap). Also highly similar to others e.g. CAB96031.1|AL360055 putative metal transporter ATPase from Streptomyces coelicolor (753 aa); NP_241423.1|NC_002570 copper-transporting ATPase from Bacillus halodurans (806 aa); etc. Also highly similar to Z46257|MLACEA_7 aceA gene for isocitrate L from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615,E():0, (76.5% identity in 752 aa overlap). And similar to MTCY251.11 from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain, PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.	X2BE13,P59947,P59947	No				P59947					X2BE13,P59947										
NC_002945.3	Mycobrowser_v4	CDS	124016	124300	.	-	0	Mb0108c	rpmB1		50s ribosomal protein l28-1 rpmb1	Mb0108c, rpmB1, len: 94 aa. Equivalent to Rv0105c,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Probable rpmB1, 50S ribosomal protein L28-1, highly similar to others e.g. Q9X8K8|R28B_STRCO 50S RIBOSOMAL PROTEIN L28-2 from Streptomyces coelicolor (78 aa); RL28_ECOLI|P02428 50s ribosomal protein l28 from Escherichia coli (77 aa), FASTA scores: opt: 167, E(): 6.2e-06, (40.7% identity in 59 aa overlap); etc. Also similar to MTCY63A_2 from Mycobacterium tuberculosis. BELONGS TO THE L28P FAMILY OF RIBOSOMAL PROTEINS.	X2BE14,P0A5V7,P0A5V7	No				P0A5V7					X2BE14,P0A5V7										
NC_002945.3	Mycobrowser_v4	CDS	125701	130578	.	-	0	Mb0111c	ctpI		PROBABLE CATION-TRANSPORTER ATPASE I CTPI	Mb0111c, ctpI, len: 1625 aa. Equivalent to 5' end of Rv0107c, len: 1632 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1572 aa overlap). Probable ctpI, cation-transporting ATPase I P-type (EC 3.6.3.-), highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium leprae (1609 aa); and similar to others e.g. CAB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 603, E(): 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium tuberculosis, FASTA score: (34.4% identity in 796 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-t) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U2U7,A0A1R3XUB9	No				A0A1R3XUB9				IPR001757,IPR006068,IPR008250,IPR018303,IPR023214,IPR023298,IPR023299	Q7U2U7										
NC_002945.3	Mycobrowser_v4	CDS	162696	162863	.	+	0	Mb0139-4	ephf		possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase)	Mb0139-4, -, len: 55 aa. Pseudogene part4 of Rv0134/ephF.		No																			
NC_002945.3	Mycobrowser_v4	CDS	131420	132910	.	+	0	Mb0113	PE_PGRS1		pe-pgrs family protein pe_pgrs1	Mb0113, PE_PGRS1, len: 496 aa. Equivalent to Rv0109, len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 496 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. Q50615|Y0DP_MYCTU HYPOTHETICAL GLYCINE-RICH 40.8 KD PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1772, E(): 0, (57.3% identity in 513 aa overlap); etc.	Q7U2U5,A0A1R3XUD2	No	PE/PPE			A0A1R3XUD2				IPR000084	Q7U2U5					Rv0109		Rv0109			
NC_002945.3	Mycobrowser_v4	CDS	136327	137283	.	+	0	Mb0116	gca		POSSIBLE GDP-MANNOSE 4,6-DEHYDRATASE GCA (GDP-D-MANNOSE DEHYDRATASE)	Mb0116, gca, len: 318 aa. Equivalent to Rv0112,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Possible gca,GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21,(27.0% identity in 318 aa overlap). Similar to Rv3634c,Rv3784, etc from Mycobacterium tuberculosis. Contains PS00061 Short-chain dehydrogenases/reductases family signature. SEEMS TO BELONG TO THE GDP-MANNOSE 4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+).	Q7U2U2,A0A1R3XUD5	No	cell wall and cell processes			A0A1R3XUD5				IPR001509,IPR016040,IPR020904	Q7U2U2					Rv0112		Rv0112			
NC_002945.3	Mycobrowser_v4	CDS	138702	139619	.	+	0	Mb0119	hdda		possible d-alpha-d-heptose-7-phosphate kinase hdda	Mb0119, -, len: 305 aa. Equivalent to Rv0115, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(98.5% identity in 275 aa overlap). Possible sugar kinase (EC 2.-.-.-), similar to several hypothetical proteins and sugar kinases e.g. AAK27850.1|AF324836_3 D-glycero-D-manno-heptose 7-phosphate kinase from Aneurinibacillus thermoaerophilus (341 aa); AAK80995.1|AE007802_11 Sugar kinase from Clostridium acetobutylicum (364 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U2U0,A0A1R3XUJ8	No	cell wall and cell processes			A0A1R3XUJ8				IPR001174,IPR006204,IPR013750,IPR014606,IPR014721,IPR020568	Q7U2U0					Rv0115		Rv0115			
NC_002945.3	Mycobrowser_v4	CDS	140307	141062	.	-	0	Mb0120c	ldta		probable l,d-transpeptidase ldta	Mb0120c, -, len: 251 aa. Equivalent to Rv0116c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 251 aa overlap). Possible conserved membrane protein, showing similarity to several hypothetical mycobacterial proteins e.g. Rv1433 from Mycobacterium tuberculosis (271 aa); and Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa); to the C-terminal regions of others like Rv0192 from Mycobacterium tuberculosis (366 aa), FASTA scores: opt: 451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7% identity in 221 aa overlap). TBparse score is 0.932.	Q7U2T9,A0A1R3XUZ1	No	cell wall and cell processes			A0A1R3XUZ1				IPR005490	Q7U2T9					Rv0116c		Rv0116c			
NC_002945.3	Mycobrowser_v4	CDS	141240	142184	.	+	0	Mb0121	oxyS		OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN OXYS	Mb0121, oxyS, len: 314 aa. Equivalent to Rv0117,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). OxyS, oxidative stress response protein regulatory protein, LysR family (see citation below). Similar to many transcription regulators and OxyR, the oxidative stress response protein of many bacteria. Contains LysR family signature at N-terminus. Also contains helix-turn-helix motif at aa 16-37 (Score 1543, +4.44 SD). BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. OXYR IS REQUIRED FOR THE INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES SUCH AS CATALASE, GLUTATHIONE-REDUCTASE, ETC.	Q7U2T8,A0A1R3XUC9	No	regulatory proteins			A0A1R3XUC9				IPR000847,IPR005119,IPR011991	Q7U2T8					Rv0117		Rv0117			
NC_002945.3	Mycobrowser_v4	CDS	142168	143916	.	-	0	Mb0122c	oxcA		PROBABLE OXALYL-COA DECARBOXYLASE OXCA	Mb0122c, oxcA, len: 582 aa. Equivalent to Rv0118c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 582 aa overlap). Probable oxcA,oxalyl-CoA decarboxylase (EC 4.1.1.8), highly similar to many e.g. P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 PROBABLE OXALYL-CoA DECARBOXYLASE from Escherichia coli (564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from Oxalobacter formigenes (568 aa), FASTA scores: opt: 2124,E():0, (55.6% identity in 568 aa overlap). Also similar to mycobacterial IlvB proteins e.g. MLCB1788.46c unknown TPP-requiring enzyme from Mycobacterium leprae (548 aa); and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa),FASTA scores: opt: 831, E(): 0, (33.9% identity in 567 aa overlap).	Q7U2T7,A0A1R3XUD1	No				A0A1R3XUD1				IPR011766,IPR012000,IPR012001,IPR017660	Q7U2T7										
NC_002945.3	Mycobrowser_v4	CDS	1791019	1791366	.	+	0	Mb1632	hisI		Probable phosphoribosyl-AMP 1,6 cyclohydrolase hisI	Mb1632, hisI, len: 115 aa. Equivalent to Rv1606,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 115 aa overlap). Probable hisI,phosphoribosyl-AMP 1,6 cyclohydrolase (EC 3.5.4.19),similar to several e.g. X82010|RSHISI_2 HISI from Rhodobacter sphaeroides (119 aa), FASTA scores: opt: 378,E(): 2.8e-21, (52.3% identity in 109 aa overlap); etc.	X2BIF1,P0A5B4,P0A5B4	No	intermediary metabolism and respiration			P0A5B4					X2BIF1,P0A5B4					Rv1606		Rv1606			
NC_002945.3	Mycobrowser_v4	CDS	144089	145666	.	+	0	Mb0123	fadD7		PROBABLE FATTY-ACID-COA LIGASE FADD7 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb0123, fadD7, len: 525 aa. Equivalent to Rv0119,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable fadD7,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to 4-coumarate:CoA ligase of many organisms e.g. U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus taedaxylem (537 aa), FASTA scores: opt: 483, E(): 8.3e-22,(28.2% identity in 440 aa overlap). Contains PS00455 Putative AMP-binding domain signature. TBscore is 0.896.	Q7U2T6,A0A1R3XUE7	No				A0A1R3XUE7				IPR000873,IPR020845,IPR025110	Q7U2T6										
NC_002945.3	Mycobrowser_v4	CDS	152515	154320	.	+	0	Mb0131	treS		TREHALOSE SYNTHASE TRES	Mb0131, treS, len: 601 aa. Equivalent to Rv0126,len: 601 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 601 aa overlap). treS, trehalose synthase (EC 5.4.99.-) (see citation below), highly similar to others e.g. CAA04601.2|AJ001205 putative trehalose synthase from Streptomyces coelicolor (566 aa); S71450|1536814|BAA11303.1|D78198 trehalose synthase maltose-specific from Pimelobacter sp. strain R48 (573 aa). Also similar to MAL1_DROME|P07191 possible maltase precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7% identity in 504 aa overlap); and similar to proteins associated with amino-acid transport e.g. Q64319 rat protein which stimulates transport of cystine and dibasic and neutral amino acids (683 aa), FASTA scores: opt: 839,E(): 0, (32.0% identity in 531 aa overlap). Also similar to several other Mycobacterium tuberculosis proteins e.g. Rv2471 FASTA score: (31.7% identity in 164 aa overlap).	Q7U2S8,A0A1R3XUD9	No	virulence, detoxification, adaptation			A0A1R3XUD9				IPR006047,IPR006589,IPR012810,IPR013780,IPR013781,IPR015902,IPR017853,IPR022567	Q7U2S8					Rv0126		Rv0126			
NC_002945.3	Mycobrowser_v4	CDS	154423	155790	.	+	0	Mb0132	mak		maltokinase mak	Mb0132, -, len: 455 aa. Equivalent to Rv0127, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 455 aa overlap). Conserved hypothetical protein, highly similar to various proteins e.g. AJ0012|SCJ001205_4 hypothetical protein from Streptomyces coelicolor A3(2) (464 aa), FASTA scores: opt: 412, E(): 1.1e-19, (40.6% identity in 485 aa overlap); AJ0012|SCJ001206_5 hypothetical protein from Streptomyces coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E(): 4.3 e-19, (36.5% identity in 455 aa overlap).	X2BE38,Q7U2S7,Q7U2S7	No	virulence, detoxification, adaptation			Q7U2S7					X2BE38,Q7U2S7					Rv0127		Rv0127			
NC_002945.3	Mycobrowser_v4	CDS	145667	147460	.	-	0	Mb0124c	fusA2b		PROBABLE ELONGATION FACTOR G FUSA2B [SECOND PART] (EF-G)	Mb0124c, fusA2b, len: 597 aa. Equivalent to 3' end of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 597 aa overlap). Probable fusA2 (alternate gene name: fus2), elongation factor G,highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia coli (703 aa), FASTA scores: opt: 1049, E(): 0, (32.5% identity in 717 aa overlap). Also similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FASTA score: (39.1% identity in 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G (EF-G) from Mycobacterium leprae (701 aa), FASTA score: (31.7% identity in 710 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fusA2 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (gc-t), splits fusA2 into 2 parts, fusA2a and fusA2b.	Q7U2T5,A0A1R3XUD3	No				A0A1R3XUD3				IPR000640,IPR000795,IPR004161,IPR005517,IPR009000,IPR009022,IPR014721,IPR020568,IPR027417	Q7U2T5										
NC_002945.3	Mycobrowser_v4	CDS	197852	198721	.	+	0	Mb0174	yrbE1B		conserved integral membrane protein yrbe1b	Mb0174, yrbE1B, len: 289 aa. Equivalent to Rv0168,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). yrbE1B, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 223,E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc.	Q7U2P0,A0A1R3XUI6	No				A0A1R3XUI6				IPR003453	Q7U2P0										
NC_002945.3	Mycobrowser_v4	CDS	158506	159849	.	-	0	Mb0136c	fadE1		PROBABLE ACYL-CoA DEHYDROGENASE FADE1	Mb0136c, fadE1, len: 447 aa. Equivalent to Rv0131c,len: 447 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 447 aa overlap). Probable fadE1,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain specific precursor (412 aa), FASTA scores: opt: 522, E(): 1.4e-23, (30.1% identity in 425 aa overlap). Also highly similar to MTCI5_28 from Mycobacterium tuberculosis.	Q7U2S4,A0A1R3XUG6	No				A0A1R3XUG6				IPR006091,IPR009075,IPR009100,IPR013786	Q7U2S4										
NC_002945.3	Mycobrowser_v4	CDS	147457	147810	.	-	0	Mb0125c	fusA2a		PROBABLE ELONGATION FACTOR G FUSA2A [FIRST PART] (EF-G)	Mb0125c, fusA2a, len: 117 aa. Equivalent to 5' end of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 108 aa overlap). Probable fusA2 (alternate gene name: fus2), elongation factor G,highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia coli (703 aa), FASTA scores: opt: 1049, E(): 0, (32.5% identity in 717 aa overlap). Also similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FASTA score: (39.1% identity in 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G (EF-G) from Mycobacterium leprae (701 aa), FASTA score: (31.7% identity in 710 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fusA2 exists as a single gene. In Mycobacterium bovis, a frameshift due to the substitution of a single base (gc-t), splits fusA2 into 2 parts, fusA2a and fusA2b.	Q7U2T4,A0A1R3XUG5	No				A0A1R3XUG5				IPR000795,IPR027417	Q7U2T4										
NC_002945.3	Mycobrowser_v4	CDS	149571	151187	.	+	0	Mb0129	PE_PGRS2		pe-pgrs family protein pe_pgrs2	Mb0129, PE_PGRS2, len: 538 aa. Similar to Rv0124,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(87.4% identity in 547 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1730, E(): 0, (60.7% identity in 504 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa).	Q7U2T0,A0A1R3XUK9	No				A0A1R3XUK9				IPR000084	Q7U2T0										
NC_002945.3	Mycobrowser_v4	CDS	151339	152406	.	+	0	Mb0130	pepA		probable serine protease pepa (serine proteinase) (mtb32a)	Mb0130, pepA, len: 355 aa. Equivalent to Rv0125,len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 355 aa overlap). Probable pepA, serine protease (EC 3.4.21.-), highly similar to other proteases e.g. HHOB_ECOLI|P31137 protease hhob precursor (355 aa),FASTA scores: opt: 400, E(): 3.8e-14, (32.4% identity in 346 aa overlap). Also similar to Q50320 34 KDA protein precursor from Mycobacterium tuberculosis (361 aa), FASTA scores: opt: 1689, E(): 0, (70.7% identity in 362 aa overlap). Contains PS00135 Serine proteases, trypsin family, serine active site. Has a possible signal sequence at the N-terminus.	Q7U2S9,A0A1R3XV06	No	intermediary metabolism and respiration			A0A1R3XV06				IPR001478,IPR001940,IPR006311,IPR009003	Q7U2S9					Rv0125		Rv0125			
NC_002945.3	Mycobrowser_v4	CDS	156769	157791	.	-	0	Mb0134c	fbpC		SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C)	Mb0134c, fbpC, len: 340 aa. Equivalent to Rv0129c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 340 aa overlap). fbpC (alternate gene names: mpt45, 85C, fbpC2), secreted antigen 85c (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below), also highly similar to other Mycobacterial antigen precursors e.g. A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1937,E(): 0, (81.4% identity in 333 aa overlap); etc.	X2BE42,P0A4V5,P0A4V5	No				P0A4V5					X2BE42,P0A4V5										
NC_002945.3	Mycobrowser_v4	CDS	158038	158493	.	+	0	Mb0135	htdz		probable 3-hydroxyl-thioester dehydratase	Mb0135, -, len: 151 aa. Equivalent to Rv0130, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, most similar to AL096811|SCI30A_19 from Streptomyces coelicolor (153 aa), FASTA scores: opt: 639, E(): 0, (60.8% identity in 148 aa overlap). Also similar to NODN_RHILV|P08634 nodulation protein from Rhizobium leguminosarum bv. viciae plasmid pRL1JI (161 aa), FASTA scores: opt: 406, E(): 1e-21, (43.9% identity in 148 aa overlap; and to O30041 MONOAMINE OXIDASE REGULATORY PROTEIN (146 aa), FASTA scores: opt: 219, E(): 1.1e-08, (30.8% identity in 133 aa overlap).	X2BE39,Q7U2S5,Q7U2S5	No	intermediary metabolism and respiration			Q7U2S5					X2BE39,Q7U2S5					Rv0130		Rv0130			
NC_002945.3	Mycobrowser_v4	CDS	159891	160973	.	-	0	Mb0137c	fgd2		putative f420-dependent glucose-6-phosphate dehydrogenase fgd2	Mb0137c, fgd2, len: 360 aa. Equivalent to Rv0132c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 360 aa overlap). Putative fgd2,F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), highly similar to many from Mycobacteria e.g. AAD38167|g5031431 from Mycobacterium chelonae. Also similar to MJ1534|Q58929 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE from METHANOCOCCUS JANNASCHII (342 aa), FASTA scores: opt: 285, E(): 7.9e-11,(28.4% identity in 292 aa overlap). And also similar to Rv0953c, Rv0791c, etc from Mycobacterium tuberculosis. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U2S3,A0A1R3XWK9	No				A0A1R3XWK9				IPR011251,IPR019945	Q7U2S3										
NC_002945.3	Mycobrowser_v4	CDS	163556	164881	.	+	0	Mb0141	cyp138		PROBABLE CYTOCHROME P450 138 CYP138	Mb0141, cyp138, len: 441 aa. Equivalent to Rv0136,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable cyp138,cytochrome P450 138 (EC 1.14.-.-), similar to others e.g. SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 aa), FASTA scores: opt: 315, E(): 1e-13, (25.7% identity in 416 aa overlap); etc. Also similar to MTV039_6 from Mycobacterium tuberculosis (472 aa), FASTA score: (38.2% identity in 442 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.	X2BE52,P63718,P63718	No				P63718					X2BE52,P63718										
NC_002945.3	Mycobrowser_v4	CDS	164902	165450	.	-	0	Mb0142c	msrA		PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) REDUCTASE)	Mb0142c, msrA, len: 182 aa. Equivalent to Rv0137c,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable msrA,peptide methionine sulfoxide reductase (EC 1.8.4.6),equivalent to CAC32179.1|AL583926 putative peptide methionine sulfoxide from Mycobacterium leprae (177 aa). Highly similar to others e.g. CAC18703.1|AL451182 putative peptide methionine sulfoxide reductase from Streptomyces coelicolor (172 aa); PMSR_SCHPO|Q09859 putative peptide methionine sulfoxide reductase from Streptomyces (187 aa),FASTA scores: opt: 468, E(): 9.9e-26, (45.6% identity in 158 aa overlap); etc. BELONGS TO THE MSRA FAMILY.	X2BE48,P0A5L1,P0A5L1	No				P0A5L1					X2BE48,P0A5L1										
NC_002945.3	Mycobrowser_v4	CDS	209895	211004	.	-	0	Mb0185c	lprO		possible lipoprotein lpro	Mb0185c, lprO, len: 369 aa. Equivalent to Rv0179c,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 369 aa overlap). Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U2M9,A0A1R3XUJ2	No				A0A1R3XUJ2				IPR018711	Q7U2M9										
NC_002945.3	Mycobrowser_v4	CDS	177733	179499	.	-	0	Mb0156c	PE1		pe family protein pe1	Mb0156c, PE1, len: 588 aa. Equivalent to Rv0151c,len: 588 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 588 aa overlap). Member of the Mycobacterium tuberculosis PE family, with N-terminal region similar to others e.g. MTV032_2 PE_PGRS family from Mycobacterium tuberculosis (468 aa), FASTA scores: opt: 1125, E(): 0, (46.3% identity in 456 aa overlap); MTCY493_24 from M. tuberculosis FASTA score: (42.5% identity in 558 aa overlap). Also similar to upstream ORF MTCI5.26c FASTA score: (54.7% identity in 464 aa overlap). Also shows similarity to C-terminal part of some PPE family proteins e.g. MTV049_21 from Mycobacterium tuberculosis FASTA score: (41.5% identity in 591 aa overlap).	Q7U2Q7,A0A1R3XUJ3	No				A0A1R3XUJ3				IPR000084,IPR013228	Q7U2Q7										
NC_002945.3	Mycobrowser_v4	CDS	179509	181086	.	-	0	Mb0157c	PE2		pe family protein pe2	Mb0157c, PE2, len: 525 aa. Equivalent to Rv0152c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to ORF downstream Z92770|MTCI5_25 (588 aa), FASTA scores: opt: 1492, E(): 0, (54.7% identity in 464 aa overlap); and to many other PE family type members.	Q7U2Q6,A0A1R3XUI3	No				A0A1R3XUI3				IPR013228	Q7U2Q6										
NC_002945.3	Mycobrowser_v4	CDS	181345	182175	.	-	0	Mb0158c	ptbB		PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)	Mb0158c, ptbB, len: 276 aa. Equivalent to Rv0153c,len: 276 aa, from Mycobacterium tuberculosis strain H27Rv,(99.6% identity in 276 aa overlap). ptbB (alternate gene name: MPtpB), protein-tyrosine-phosphatase (see citation below) (EC 3.1.3.48), showing some similarity to several protein-tyrosine phosphatases, polyketide synthase and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed a secreted protein.	Q7U2Q5,A0A1R3XWN1	No				A0A1R3XWN1				IPR000387,IPR025163,IPR026893	Q7U2Q5										
NC_002945.3	Mycobrowser_v4	CDS	182177	183388	.	-	0	Mb0159c	fadE2		PROBABLE ACYL-CoA DEHYDROGENASE FADE2	Mb0159c, fadE2, len: 403 aa. Equivalent to Rv0154c,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 403 aa overlap). Probable fadE2,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. C-terminal region of O01590 ACYL-CoA DEHYDROGENASE (974 aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain) (383 aa), FASTA score: (35.0% identity in 306 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7U2Q4,A0A1R3XVL8	No				A0A1R3XVL8				IPR006091,IPR009075,IPR009100,IPR013786	Q7U2Q4										
NC_002945.3	Mycobrowser_v4	CDS	183812	184912	.	+	0	Mb0160	pntAa		PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAa [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA)	Mb0160, pntAa, len: 366 aa. Equivalent to Rv0155,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 366 aa overlap). Probable pntAa, first part of NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2), similar to N-terminus of others e.g. PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase subunit alpha from Escherichia coli strain K12 (510 aa),FASTA scores: opt: 921, E(): 0, (42.1% identity in 361 aa overlap); PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA (EC 1.6.1.1).	Q7U2Q3,A0A1R3XUN9	No				A0A1R3XUN9				IPR007698,IPR007886,IPR026255	Q7U2Q3										
NC_002945.3	Mycobrowser_v4	CDS	184913	185245	.	+	0	Mb0161	pntAb		PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAb [SECOND PART; INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA)	Mb0161, pntAb, len: 110 aa. Equivalent to Rv0156,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 110 aa overlap). Probable pntAb, second part of NAD(P) transhydrogenase subunit alpha, integral membrane protein, similar to C-terminus of others e.g. Q59764 NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAB (139 aa), FASTA scores: opt: 247, E(): 1.9e-11,(45.5% identity in 88 aa overlap).	Q7U2Q2,A0A1R3XV34	No				A0A1R3XV34				IPR024605	Q7U2Q2										
NC_002945.3	Mycobrowser_v4	CDS	185242	186669	.	+	0	Mb0162	pntB		PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA)	Mb0162, pntB, len: 475 aa. Equivalent to Rv0157,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 475 aa overlap). Probable pntB,pyridine nucleotide transhydrogenase (nicotinamide nucleotide transhydrogenase) subunit beta (EC 1.6.1.1),integral membrane protein, similar to others e.g. Q59763 PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity in 472 aa overlap); P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli strains K12 and O157:H7 (462 aa).	Q7U2Q1,A0A1R3XUG9	No	intermediary metabolism and respiration			A0A1R3XUG9				IPR012136	Q7U2Q1					Rv0157		Rv0157			
NC_002945.3	Mycobrowser_v4	CDS	187623	189029	.	-	0	Mb0164c	PE3		pe family protein pe3	Mb0164c, PE3, len: 468 aa. Equivalent to Rv0159c,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 468 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many other PE proteins e.g. O06828 from Mycobacterium tuberculosis (528 aa), FASTA scores: opt: 1163, E(): 0,(45.8% identity in 467 aa overlap). Also highly similar to upstream MTV032_3, and to MTCI5_25, MTCI5_26, MTV049_ 21,MTCY1A10_26, etc.	Q7U2P9,A0A1R3XUH4	No				A0A1R3XUH4				IPR000084,IPR013228	Q7U2P9										
NC_002945.3	Mycobrowser_v4	CDS	189121	190629	.	-	0	Mb0165c	PE4		pe family protein pe4	Mb0165c, PE4, len: 502 aa. Equivalent to Rv0160c,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 502 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many other PE proteins e.g. Z92770|MTCI5_26c from M. tuberculosis (525 aa), FASTA scores: opt: 816, E(): 0,(41.4% identity in 367 aa overlap); C-terminal region of O06801|RV1768|MTCY28.34 from Mycobacterium tuberculosis (618 aa), FASTA scores: opt: 417, E(): 6.7e-18, (53.5% identity in 142 aa overlap). Also highly similar to downstream ORF MTV032_2.	Q7U2P8,A0A1R3XUK0	No				A0A1R3XUK0				IPR000084,IPR013228	Q7U2P8										
NC_002945.3	Mycobrowser_v4	CDS	211084	212442	.	-	0	MbXXXXc	Mb0186c		PROBABLE CONSERVED TRANSMEMBRANE PROTEIN	MbXXXXc -, len: 452 aa. Equivalent to Rv0180c, len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 452 aa overlap). Probable conserved transmembrane protein, equivalent to CAC32132.1|AL583926 probable conserved membrane protein from Mycobacterium leprae (465 aa). Shows some similarity with others membrane proteins e.g. AL096849|SCI11_29 from Streptomyces coelicolor (354 aa), FASTA scores: opt: 190, E(): 0.00067,(25.9% identity in 409 aa overlap).	Q7U2M8,A0A1R3XUM0	No	cell wall and cell processes			A0A1R3XUM0				IPR022703	Q7U2M8					Rv0180c		Rv0180c			
NC_002945.3	Mycobrowser_v4	CDS	192174	193325	.	-	0	Mb0167c	adhE1		probable zinc-type alcohol dehydrogenase (e subunit) adhe1	Mb0167c, adhE1, len: 383 aa. Equivalent to Rv0162c,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Probable adhE1,zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7% identity in 363 aa overlap). Also similar to other alcohol dehydrogenases from Mycobacterium tuberculosis e.g. MTCY369.06c FASTA score: (34.0% identity in 365 aa overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa overlap). Contains PS00059 Zinc-contain ingalcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR: ZINC.	Q7U2P6,A0A1R3XWN8	No				A0A1R3XWN8				IPR002085,IPR002328,IPR011032,IPR013149,IPR013154,IPR016040	Q7U2P6										
NC_002945.3	Mycobrowser_v4	CDS	197053	197850	.	+	0	Mb0173	yrbE1A		conserved integral membrane protein yrbe1a	Mb0173, yrbE1A, len: 265 aa. Equivalent to Rv0167,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). yrbE1A, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar or similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa),FASTA scores: opt: 328, E(): 1.8e-15, (26.6% identity in 244 aa overlap); etc.	Q7U2P1,A0A1R3XUI7	No				A0A1R3XUI7				IPR003453	Q7U2P1										
NC_002945.3	Mycobrowser_v4	CDS	194315	195007	.	-	0	Mb0170c	mce1R		Probable transcriptional regulatory protein Mce1R (probably GntR-family)	Mb0170c, len: 230 aa. Equivalent to Rv0165c len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(81.2% identity in 218 aa overlap). Probable mce1R,transcriptional regulator, GntR family (See Casali et al.,2006), showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI gluconate operon transcriptional repressor from Bacillus licheniformis (243 aa); GNTR_BACSU gluconate operon repressor from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. Seems to belong to the GntR family of transcriptional regulators. Start changed since first submission (-41 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus.	X2BE70,A0A1R3XV40	No	regulatory proteins			A0A1R3XV40					X2BE70					Rv0165c		Rv0165c			
NC_002945.3	Mycobrowser_v4	CDS	194334	194513	.	-	0	Mb0171c	mce1r		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY)	Mb0171c, -, len: 59 aa. Equivalent to 3' end of Rv0165c, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 57 aa overlap). Possible transcriptional regulator, GntR family, showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH part. Mb0171c corresponds to the remnant COOH part of Rv0165c.		No																			
NC_002945.3	Mycobrowser_v4	CDS	195185	196849	.	+	0	Mb0172	fadD5		PROBABLE FATTY-ACID-CoA LIGASE FADD5 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Mb0172, fadD5, len: 554 aa. Equivalent to Rv0166,len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 554 aa overlap). Probable fadD5,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many eg LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in 534 aa overlap). Also similar to many other fatty-acid-CoA ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c FASTA score: (35.3% identity in 487 aa overlap),MTV013_10, MTY25D10_30, etc. Contains PS00455 putative AMP-binding domain signature.	Q7U2P2,A0A1R3XUH8	No				A0A1R3XUH8				IPR000873,IPR020845,IPR025110	Q7U2P2										
NC_002945.3	Mycobrowser_v4	CDS	198726	200090	.	+	0	Mb0175	mce1A		MCE-FAMILY PROTEIN MCE1A	Mb0175, mce1A, len: 454 aa. Equivalent to Rv0169,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 454 aa overlap). mce1A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene product from Mycobacterium avium (88 aa) (similarity on C-terminus); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Note that equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 Mcep protein from Mycobacterium tuberculosis (432 aa). Contains a very hydrophobic region around residues 20-35. Note that previously known as mce1.	Q7U2N9,A0A1R3XUI4	No				A0A1R3XUI4				IPR003399,IPR005693,IPR024516	Q7U2N9										
NC_002945.3	Mycobrowser_v4	CDS	200087	201127	.	+	0	Mb0176	mce1B		MCE-FAMILY PROTEIN MCE1B	Mb0176, mce1B, len: 346 aa. Equivalent to Rv0170,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 346 aa overlap). mce1B (alternate gene name: mceD); belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa); etc. Contains hydrophobic region in N-terminal 30 residues. In Escherichia coli, N-terminal part is functional and directs export of a leaderless beta-lactamase into the periplasm (see seventh citation).	Q7U2N8,A0A1R3XUL1	No				A0A1R3XUL1				IPR003399,IPR005693,IPR024516	Q7U2N8										
NC_002945.3	Mycobrowser_v4	CDS	201124	202671	.	+	0	Mb0177	mce1C		MCE-FAMILY PROTEIN MCE1C	Mb0177, mce1C, len: 515 aa. Equivalent to Rv0171,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). mce1C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Weakly similar to downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA score: (24.6% identity in 552 aa overlap). Contains possible signal sequence and highly proline-rich C-terminus.	Q7U2N7,A0A1R3XUJ9	No				A0A1R3XUJ9				IPR003399,IPR005693,IPR008360	Q7U2N7										
NC_002945.3	Mycobrowser_v4	CDS	202668	204260	.	+	0	Mb0178	mce1D		MCE-FAMILY PROTEIN MCE1D	Mb0178, mce1D, len: 530 aa. Equivalent to Rv0172,len: 530 aa, fromMycobacterium tuberculosis strain H37Rv,(100.0% identity in 530 aa overlap). mce1D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Hydrophobic region at N-terminus.	Q7U2N6,A0A1R3XWP7	No				A0A1R3XWP7				IPR003399,IPR005693	Q7U2N6										
NC_002945.3	Mycobrowser_v4	CDS	204257	205429	.	+	0	Mb0179	lprK		POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E)	Mb0179, lprK, len: 390 aa. Equivalent to Rv0173,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 390 aa overlap). Possible lprK (alternate gene name: mce1E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains PS00013 prokaryotic membrane lipoprotein lipid attachment site.	Q7U2N5,A0A1R3XVP0	No	cell wall and cell processes			A0A1R3XVP0				IPR003399,IPR005693	Q7U2N5					Rv0173		Rv0173			
NC_002945.3	Mycobrowser_v4	CDS	205423	206970	.	+	0	Mb0180	mce1F		MCE-FAMILY PROTEIN MCE1F	Mb0180, mce1F, len: 515 aa. Equivalent to Rv0174,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). mce1F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Has hydrophobic stretch, possibly a signal peptide at the N-terminus.	Q7U2N4,A0A1R3XUQ9	No				A0A1R3XUQ9				IPR003399,IPR005693	Q7U2N4										
NC_002945.3	Mycobrowser_v4	CDS	213220	214332	.	-	0	Mb0188c	sigG		PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR)	Mb0188c, sigG, len: 370 aa. Equivalent to Rv0182c,len: 370 aa (start site uncertain; first of several possibles was chosen, but note that this overlaps the upstream ORF), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 370 aa overlap). Probable sigG,alternative RNA polymerase sigma subunit (see citations below), similar to many e.g. Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FACTOR from Bacillus subtilis (187 aa). Also similar to nine other ECF sigma factors from Mycobacterium tuberculosis e.g. Rv1221, Rv0735, etc. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 205-226 (Score 1181, +3.21 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY,ECF SUBFAMILY.	Q7U2M7,A0A1R3XWR0	No				A0A1R3XWR0				IPR000838,IPR007627,IPR009959,IPR011991,IPR013249,IPR013324,IPR013325,IPR014284,IPR014305	Q7U2M7										
NC_002945.3	Mycobrowser_v4	CDS	216461	218536	.	+	0	Mb0192	bglS		PROBABLE BETA-GLUCOSIDASE BGLS (GENTIOBIASE) (CELLOBIASE) (BETA-D-GLUCOSIDE GLUCOHYDROLASE)	Mb0192, bglS, len: 691 aa. Equivalent to Rv0186,len: 691 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 691 aa overlap). Probable bglS,beta-glucosidase (EC 3.2.1.21), highly similar to many e.g. BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0,(32.5% identity in 842 aa overlap). SEEMS TO BELONG TO FAMILY 3 OF GLYCOSYL HYDROLASES.	Q7U2M3,A0A1R3XUK5	No	intermediary metabolism and respiration			A0A1R3XUK5				IPR001764,IPR002772,IPR017853,IPR026891,IPR026892	Q7U2M3					Rv0186		Rv0186			
NC_002945.3	Mycobrowser_v4	CDS	218582	218743	.	-	0	Mb0192A	mymT		Metallothionein, MymT	Mb0192A, len: 53 aa. Equivalent to Rv0186A len: 53 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 53 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). MymT,metallothionein,equivalent to MAV_4993|A0QMH5 hypothetical protein from Mycobacterium avium (strain 104) (51 aa), and MAP_3626c|Q73TU2 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (51 aa), FASTA scores: opt: 312, E(): 4.6e-17, (81.2% identity in 48 aa overlap).	X2BEB8,A0A1R3XUK6	No	virulence, detoxification, adaptation			A0A1R3XUK6					X2BEB8					Rv0186A		Rv0186A			
NC_002945.3	Mycobrowser_v4	CDS	220188	221915	.	-	0	Mb0195c	ilvD		PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD)	Mb0195c, ilvD, len: 575 aa. Equivalent to Rv0189c,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 575 aa overlap). Probable ilvD,dihydroxy-acid dehydratase (EC 4.2.1.9), similar to many e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (570 aa), FASTA scores: opt: 1605, E(): 0, (46.0% identity in 561 aa overlap). Also similar to ML2608|MLCL622.06c|O06069|ILVD_MYCLE DIHYDROXY-ACID DEHYDRATASE from Mycobacterium leprae (564 aa). Contains PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. BELONGS TO THE ILVD / EDD FAMILY. COFACTOR: BINDS 1 4FE-4S CLUSTER (POTENTIAL).	X2BEA6,P65155,P65155	No				P65155					X2BEA6,P65155										
NC_002945.3	Mycobrowser_v4	CDS	234712	236703	.	-	0	Mb0204c	zmp1		probable zinc metalloprotease zmp1	Mb0204c, -, len: 663 aa. Equivalent to Rv0198c,len: 663 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 663 aa overlap). Probable zinc metalloprotease (EC 3.4.24.-), equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa),FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 aa overlap). Also similar to many other metalloproteases e.g. members of the eukaryotic neprilysin family: P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA scores: opt: 872, E(): 0, (31.1% identity in 692 aa overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): 0, (30.0% identity in 654 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY.	Q7U2L2,A0A1R3XUL2	No	intermediary metabolism and respiration			A0A1R3XUL2				IPR000718,IPR008753,IPR018497,IPR024079	Q7U2L2					Rv0198c		Rv0198c			
NC_002945.3	Mycobrowser_v4	CDS	238588	241488	.	-	0	Mb0208c	mmpL11		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11	Mb0208c, mmpL11, len: 966 aa. Equivalent to Rv0202c, len: 966 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 966 aa overlap). Probable mmpL11, conserved transmembrane transport protein (see citation below), equivalent to Z95398|MLCL622.16c from Mycobacterium leprae (1014 aa), FASTA scores: opt: 4076, E(): 0, (72.8% identity in 1017 aa overlap). Member of RND superfamily, similar to several putative transport proteins e.g. P96687 from Bacillus subtilis (724 aa),FASTA scores: opt: 594, E(): 9.1e-29, (26.9% identity in 717 aa overlap); etc. BELONGS TO THE MMPL FAMILY.	X2BED8,P65375,P65375	No	cell wall and cell processes			P65375					X2BED8,P65375					Rv0202c		Rv0202c			
NC_002945.3	Mycobrowser_v4	CDS	244680	247514	.	-	0	Mb0212c	mmpL3		POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL3	Mb0212c, mmpL3, len: 944 aa. Equivalent to Rv0206c,len: 944 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 944 aa overlap). Possible mmpL3,conserved transmembrane transport protein (see first citation below), equivalent to Z95398|MLCL622.18c from Mycobacterium leprae (955 aa), FASTA scores: opt: 806,E(): 1.8e-21, (57.2% identity in 243 aa overlap). Member of RND superfamily, similar to others. BELONGS TO THE MMPL FAMILY. TBparse score is 0.928.	Q7U2K5,A0A1R3XUM5	No				A0A1R3XUM5				IPR000731,IPR004869	Q7U2K5										
NC_002945.3	Mycobrowser_v4	CDS	251978	253798	.	+	0	Mb0217	pckA		probable iron-regulated phosphoenolpyruvate carboxykinase [gtp] pcka (phosphoenolpyruvate carboxylase) (pepck)(pep carboxykinase)	Mb0217, pckA, len: 606 aa. Equivalent to Rv0211,len: 606 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 606 aa overlap). Probable pckA (alternate gene names: pckG and pck1), phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32), equivalent to Z95398|MLCL622_21 PROBABLE PHOSPHOENOLPYRUVATE CARBOXYKINASE from Mycobacterium leprae (609 aa), FASTA score: (86.1% identity in 605 aa overlap). Also highly similar to others e.g. PPCK_NEOFR|P22130 phosphoenolpyruvate carboxykinase [GTP] (608 aa), FASTA scores: opt: 2287, E(): 0, (55.9% identity in 598 aa overlap). Contains PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. BELONGS TO THE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] FAMILY.	X2BEE3,P65687,P65687	No	intermediary metabolism and respiration			P65687					X2BEE3,P65687					Rv0211		Rv0211			
NC_002945.3	Mycobrowser_v4	CDS	253865	254836	.	-	0	Mb0218c	nadR		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN NADR (PROBABLY ASNC-FAMILY)	Mb0218c, nadR, len: 323 aa. Equivalent to Rv0212c,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Possible nadR (alternate gene name: nadI), transcriptional regulator,similar to others e.g. NADR_ECOLI|P27278 transcriptional regulator from Escherichia coli (410 aa), FASTA scores: opt: 377, E (): 1e-17, (31.1% identity in 347 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U2K1,A0A1R3XVT3	No				A0A1R3XVT3				IPR004821,IPR006417,IPR014729,IPR016429,IPR027417	Q7U2K1										
NC_002945.3	Mycobrowser_v4	CDS	263037	264248	.	+	0	Mb0226	lipC		PROBABLE ESTERASE LIPC	Mb0226, lipC, len: 403 aa. Equivalent to Rv0220,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 403 aa overlap). Probable esterase (EC 3.1.1.-), similar to others proteins and esterases from various organisms and Mycobacterium tuberculosis e.g. Q50681 (431 aa), FASTA scores: opt: 841, E(): 0, (38.2% identity in 408 aa overlap); Rv1426c, Rv1399c, etc. Contains PS00122 Carboxylesterases type-B serine active site.	Q7U2J3,A0A1R3XUP5	No	intermediary metabolism and respiration			A0A1R3XUP5				IPR013094,IPR019826	Q7U2J3					Rv0220		Rv0220			
NC_002945.3	Mycobrowser_v4	CDS	285510	286676	.	+	0	Mb0243	lpqI		PROBABLE CONSERVED LIPOPROTEIN LPQI	Mb0243, lpqI, len: 388 aa. Equivalent to Rv0237,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 388 aa overlap). Probable lpQI,conserved lipoprotein, equivalent to AL022486|MLCB1883_8|T44873 probable secreted hydrolase from Mycobacterium leprae (387 aa), FASTA scores: opt: 1831, E(): 0, (73.3% identity in 390 aa overlap). Also similar to other lipoproteins and various hydrolases e.g. P40406|2126897|YBBD_BACSU|I39839 HYPOTHETICAL 70.6 KDA LIPOPROTEIN from Bacillus subtilis (642 aa); P48823|HEXA_ALTSO BETA-HEXOSAMINIDASE A PRECURSOR from ALTEROMONAS SP. (598 aa), FASTA scores: opt: 415, E(): 5.8e-17, (31.2% identity in 343 aa overlap); PCC6803|P74340 BETA-GLUCOSIDASE from Synechocystis sp. (538 aa), FASTA scores: opt: 414, E(): 6.1e-17, (30.6 identity in 320 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U2H7,A0A1R3XUQ4	No	cell wall and cell processes			A0A1R3XUQ4				IPR001764,IPR017853	Q7U2H7					Rv0237		Rv0237			
NC_002945.3	Mycobrowser_v4	CDS	256260	257873	.	+	0	Mb0220	fadD4		PROBABLE FATTY-ACID-COA LIGASE FADD4 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb0220, fadD4, len: 537 aa. Equivalent to Rv0214,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 537 aa overlap). Probable fadD4,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. 4CL_PINTA|P41636 4-coumarate--coa ligase (EC 6.2.1.12) (537 aa), FASTA scores: opt: 622, E(): 1e-31,(30.0% identity in 514 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY6A4.14 FASTA score: (30.7% identity in 501 aa overlap); MTCY493_27,MTCY07A7_11, MTCI28_6. Contains PS00455 putative AMP-binding domain signature.	Q7U2J9,A0A1R3XV88	No				A0A1R3XV88				IPR000873,IPR020845,IPR025110	Q7U2J9										
NC_002945.3	Mycobrowser_v4	CDS	257915	259081	.	-	0	Mb0221c	fadE3		PROBABLE ACYL-COA DEHYDROGENASE FADE3	Mb0221c, fadE3, len: 388 aa. Equivalent to Rv0215c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Probable fadE3,acyl-dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis (EC 1.3.99.-) (379 aa), FASTA scores: opt: 812, E(): 0,(39.5% identity in 354 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa).	Q7U2J8,A0A1R3XUP0	No				A0A1R3XUP0				IPR006091,IPR009075,IPR009100,IPR013786	Q7U2J8										
NC_002945.3	Mycobrowser_v4	CDS	260148	261056	.	-	0	Mb0223c	lipW		POSSIBLE ESTERASE LIPW	Mb0223c, lipW, len: 302 aa. Equivalent to Rv0217c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Possible esterase (EC 3.1.1.-), showing similarity with others e.g. EST_ACICA|P18773 esterase (303 aa), FASTA scores: opt: 320, E(): 3.2e-13, (29.2% identity in 274 aa overlap).	Q7U2J6,A0A1R3XUN3	No				A0A1R3XUN3				IPR013094	Q7U2J6										
NC_002945.3	Mycobrowser_v4	CDS	287428	287661	.	+	0	Mb0245	vapb24		possible antitoxin vapb24	Mb0245, -, len: 77 aa. Equivalent to Rv0239, len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Conserved hypothetical protein, weakly similar to Rv1839c|Z83859|MTCY359_34 from Mycobacterium tuberculosis (87 aa), FASTA scores: opt: 88,E(): 5, (40.0% identity in 45 aa overlap).	Q7U2H5,A0A1R3XUS9	No	virulence, detoxification, adaptation			A0A1R3XUS9					Q7U2H5					Rv0239		Rv0239			
NC_002945.3	Mycobrowser_v4	CDS	273307	274287	.	-	0	Mb0235c	php		PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE) (ARYLDIALKYLPHOSPHATASE) (PARAOXONASE) (A-ESTERASE) (ARYLTRIPHOSPHATASE) (PARAOXON HYDROLASE)	Mb0235c, php, len: 326 aa. Equivalent to Rv0230c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 326 aa overlap). Probable php,phosphotriesterase (EC 3.1.8.1), similar to others e.g. AAK42653.1|AE006849 putative aryldialkylphosphatase (phosphotriesterase) (paraoxonase) from Sulfolobus solfataricus (314 aa); PHP_ECOLI|P45548 PHOSPHOTRIESTERASE HOMOLOGY PROTEIN from Escherichia coli (292 aa), FASTA scores: opt: 408, E(): 7.1e-20, (31.1% identity in 305 aa overlap ); OPD_FLASP|P16648 parathion hydrolase precursor (365 aa), FASTA scores: opt: 319, E(): 5.1e-14, (34.5% identity in 333 aa overlap); etc. BELONGS TO THE PHOSPHOTRIESTERASE FAMILY. COFACTOR: CONTAINS 2 MOLES OF ZINC PER SUBUNIT.	Q7U2I4,A0A1R3XUR8	No				A0A1R3XUR8				IPR001559,IPR017947	Q7U2I4										
NC_002945.3	Mycobrowser_v4	CDS	274382	276088	.	+	0	Mb0236	fadE4		PROBABLE ACYL-COA DEHYDROGENASE FADE4	Mb0236, fadE4, len: 568 aa. Equivalent to Rv0231,len: 568 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 568 aa overlap). Probable fadE4,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. O29752 ACYL-COA DEHYDROGENASE (ACD-3) from Archaeoglobus fulgidus (576 aa), FASTA scores: opt: 1788, E(): 0, (51.0% identity in 577 aa overlap); ACDB_BACSU|P45857 acyl-coa dehydrogenase from Bacillus subtilis (379 aa), FASTA scores: opt: 232, E(): 2.2e- 08, (21.6% identity in 291 aa overlap).	Q7U2I3,A0A1R3XUQ6	No				A0A1R3XUQ6				IPR006091,IPR009075,IPR009100	Q7U2I3										
NC_002945.3	Mycobrowser_v4	CDS	276909	277853	.	+	0	Mb0238	nrdB		ribonucleoside-diphosphate reductase (beta chain) nrdb (ribonucleotide reductase small chain)	Mb0238, nrdB, len: 314 aa. Equivalent to Rv0233,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 314 aa overlap). Probable nrdB (alternate gene name: rnrS) ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1), similar to others e.g. RIR2_SCHPO|P36603 ribonucleoside-diphosphate reductase (391 aa), FASTA scores: opt: 168, E(): 0.00018,(26.1% identity in 199 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. COFACTOR: BINDS 2 IRON IONS.	X2BEH1,Q7U2I1,Q7U2I1	No	information pathways			Q7U2I1					X2BEH1,Q7U2I1					Rv0233		Rv0233			
NC_002945.3	Mycobrowser_v4	CDS	277929	279464	.	-	0	Mb0239c	gabD1		succinate-semialdehyde dehydrogenase [nadp+] dependent (ssdh) gabd1	Mb0239c, gabD1, len: 511 aa. Equivalent to Rv0234c,len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable gabD1,succinate-semialdehyde dehydrogenase [NADP+] dependent (EC 1.2.1.16), equivalent to AL022486|MLCB1883_6 PROBABLE ALDEHYDE DEHYDROGENASE from Mycobacterium leprae (457 aa),FASTA scores: opt: 2617, E(): 0, (85.7% identity in 455 aa overlap). Also highly similar to Q55585|GABD|SLR0370 PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE from Synechocystis sp. strain PCC 6803 (454 aa), FASTA scores: opt: 1676, E(): 0, (55.8% identity in 455 aa overlap); and similar to others e.g. GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from Escherichia coli (482 aa), FASTA scores: opt: 929, E(): 0, (36.5% identity in 452 aa overlap); etc. Note that similar to other cytosolic aldehyde dehydrogenases with EC number: 1.2.1.3. Also similar to Rv0768|aldA semialdehyde dehydrogenase from Mycobacterium tuberculosis (489 aa); and gabD2|Rv1731|MTCY04C12.16 POSSIBLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDANT from Mycobacterium tuberculosis (518 aa). Contains PS00070 aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Could start at different site by homology. Note that previously known as gabD2.	X2BEB3,Q7U2I0,Q7U2I0	No				Q7U2I0					X2BEB3,Q7U2I0										
NC_002945.3	Mycobrowser_v4	CDS	280973	285175	.	-	0	Mb0241c	aftd		possible arabinofuranosyltransferase aftd	Mb0241c, -, len: 1400 aa. Equivalent to Rv0236c,len: 1400 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1400 aa overlap). Probable conserved transmembrane protein, equivalent to AL022486|CAC32102.1|MLCB1883_7 possible integral membrane protein from Mycobacterium leprae (1440 aa), FASTA scores: opt: 7491, E(): 0, (78.8% identity in 1397 aa overlap).	Q7U2H8,A0A1R3XUR0	No	cell wall and cell processes			A0A1R3XUR0				IPR000421,IPR008979,IPR021798	Q7U2H8					Rv0236c		Rv0236c			
NC_002945.3	Mycobrowser_v4	CDS	704489	704734	.	+	0	Mb0624	vapb28		possible antitoxin vapb28	Mb0624, -, len: 81 aa. Equivalent to Rv0608, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical short proteins e.g. Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores: opt: 159, E(): 1.2e-09, (43.0% identity in 86 aa overlap); Rv2760c (89 aa); Rv1740 (70 aa), etc.	Q7U1M8,A0A1R3XVU9	No	virulence, detoxification, adaptation			A0A1R3XVU9				IPR011660	Q7U1M8					Rv0608		Rv0608			
NC_002945.3	Mycobrowser_v4	CDS	288136	288978	.	-	0	Mb0247c	htdx		probable 3-hydroxyacyl-thioester dehydratase htdx	Mb0247c, -, len: 280 aa. Equivalent to Rv0241c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Conserved hypothetical protein, highly similar to MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical protein from Mycobacterium leprae (280 aa), FASTA scores: opt: 1564, E(): 0, (81.8% identity in 280 aa overlap); and CAC32097.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (300 aa). Also similar to proteins from other organisms e.g. CAB77291.1|AL160312 putative dehydratase from Streptomyces coelicolor (291 aa); part of BAA92930.1|AB032743 fatty acid synthetase beta subunit from Pichia angusta (2060 aa).	Q7U2H3,A0A1R3XWX1	No	intermediary metabolism and respiration			A0A1R3XWX1				IPR002539,IPR003965	Q7U2H3					Rv0241c		Rv0241c			
NC_002945.3	Mycobrowser_v4	CDS	285222	285395	.	-	0	Mb0242c	Mb0242c		SMALL SECRETED PROTEIN	Mb0242c, -, len: 57 aa. Equivalent to Rv0236A, len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). Small secreted protein.	X2BEG4,P0A5C6	No	cell wall and cell processes			P0A5C6					X2BEG4					Rv0236A		Rv0236A			
NC_002945.3	Mycobrowser_v4	CDS	288989	290353	.	-	0	Mb0248c	fabG4		PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG4 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE)	Mb0248c, fabG4, len: 454 aa. Equivalent to Rv0242c,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 454 aa overlap). Probable fabG4,3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100),equivalent to 3063883|CAA18568.1|AL022486|MLCB1883_13|T44878 3-oxoacyl-[acyl-carrier protein] reductase homolog from Mycobacterium leprae (454 aa), FASTA scores: opt: 2486,E(): 0, (84.8% identity in 454 aa overlap). C-terminal part highly similar to many FabG proteins e.g. U39441|VHU3944 1_2 from Vibrio harveyi (244 aa), FASTA scores: opt: 562, E(): 3.4e-28, (40.2% identity in 241 aa overlap); U91631|PAU91631_3 from Pseudomonas aeruginosa (247 aa), FASTA scores: opt: 584, E(): 1.5e-29, (44.4% identity in 241 aa overlap). Has N-terminal extension of ~200 aa and C-terminal part contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7U2H2,A0A1R3XVU6	No				A0A1R3XVU6				IPR002198,IPR002347,IPR016040,IPR020904	Q7U2H2										
NC_002945.3	Mycobrowser_v4	CDS	290495	291817	.	+	0	Mb0249	fadA2		PROBABLE ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)	Mb0249, fadA2, len: 440 aa. Equivalent to Rv0243,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable fadA2,acetyl-CoA acyltransferase (3-acyl-CoA thiolase) (EC 2.3.1.16), equivalent, but shorter 17 aa, to AL022486|MLCB1883_14T44879 acetyltransferase from Mycobacterium leprae (457 aa), FASTA scores: opt: 250 7,E(): 0, (87.6% identity in 435 aa overlap). Also highly similar to many e.g. G83046|PA478 probable acyl-CoA thiolase from Pseudomonas aeruginosa (425 aa); AB77293.1|AL160312 putative ketoacyl CoA thiolase from Streptomyces coelicolor (428 aa); P76503|7449731|YFCY_ECOLI|D65007|B2342 PROBABLE 3-KETOACYL-COA THIOLASE (ACETYL-COA ACYLTRANSFERASE) (BETA-KETOTHIOLASE) from Escherichia coli strain K-12 (436 aa), FASTA scores: opt: 914, E(): 0, (38.2% identity in 434 aa overlap); P55084|ECHB_HUMAN MITOCHONDRIAL TRIFUNCTONAL ENZYME (474 aa), FASTA scores: opt: 881, E(): 0, (37.7 identity in 451 aa overlap). Contains PS00099 Thiolases active site. BELONGS TO THE THIOLASE FAMILY.	Q7U2H1,A0A1R3XUX8	No				A0A1R3XUX8				IPR002155,IPR016038,IPR016039,IPR020610,IPR020616,IPR020617	Q7U2H1										
NC_002945.3	Mycobrowser_v4	CDS	292123	293958	.	-	0	Mb0250c	fadE5		PROBABLE ACYL-COA DEHYDROGENASE FADE5	Mb0250c, fadE5, len: 611 aa. Equivalent to Rv0244c,len: 611 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 611 aa overlap). Probable fadE5,acyl-CoA dehydrogenase (EC 1.3.99.-), equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa),FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa overlap). Also highly similar to AL0211|MTV007.14 from Mycobacterium tuberculosis (609 aa), FASTA scores: opt: 2576, E(): 0, (64.6% identity in 611 aa overlap); and to various other bacterial proteins described as putative acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229,E(): 6.8e-08, (29.8% identity in 409 aa overlap); etc.	Q7U2H0,A0A1R3XVC6	No				A0A1R3XVC6				IPR006091,IPR009075,IPR009100,IPR013786,IPR020953,IPR025878	Q7U2H0										
NC_002945.3	Mycobrowser_v4	CDS	300498	300977	.	-	0	Mb0257c	hsp		HEAT SHOCK PROTEIN HSP (HEAT-STRESS-INDUCED RIBOSOME-BINDING PROTEIN A)	Mb0257c, hsp, len: 159 aa. Equivalent to Rv0251c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). hsp (alternate gene name: hsp20, hrpA, acr2), heat-stress-induced ribosome-binding protein A (see citations below). Highly similar to AAD39038.1|AF072875_1|AF072875 putative HSP20 from Mycobacterium smegmatis (145 aa), FASTA scores: opt: 479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and similar to many bacterial and eukaryotic hsp proteins e.g. P12811|HS2C_CHLRE CHLOROPLAST HEAT SHOCK 22KD PROTEIN from CHLAMYDOMONAS REINHARDTII (157 aa), FASTA scores: opt: 184, E(): 1.2e-05, (32.4% identity in 142 aa overlap). Also similar to PCC6803 Spore protein sp21 from Synechocystis sp. (146 aa), FASTA scores: opt: 213, E(): 1.2e-07, (30.3 identity in 145 aa overlap). Also similar to P30223|14KD_MYCTU 14 KDA ANTIGEN (16 KDA ANTIGEN) 19K major membrane protein (HSP 16.3) from Mycobacterium tuberculosis (144 aa). BELONG TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY.	Q7U2G3,A0A1R3XWY2	No				A0A1R3XWY2				IPR002068,IPR008978	Q7U2G3										
NC_002945.3	Mycobrowser_v4	CDS	301191	303752	.	+	0	Mb0258	nirB		PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB	Mb0258, nirB, len: 853 aa. Equivalent to Rv0252,len: 853 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 853 aa overlap). Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4), flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0,(49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA scores: opt: 2902, E(): 0, (54.2% identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. HOMODIMER WHICH ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron; Siroheme.	Q7U2G2,A0A1R3XVV3	No	intermediary metabolism and respiration			A0A1R3XVV3				IPR001327,IPR005117,IPR006066,IPR006067,IPR007419,IPR012744,IPR013027,IPR017121,IPR023753	Q7U2G2					Rv0252		Rv0252			
NC_002945.3	Mycobrowser_v4	CDS	303778	304134	.	+	0	Mb0259	nirD		PROBABLE NITRITE REDUCTASE [NAD(P)H] SMALL SUBUNIT NIRD	Mb0259, nirD, len: 118 aa. Equivalent to Rv0253,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Probable nirD,nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4),similar to others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia coli strains K12 and O157:H7 (108 aa), FASTA scores: opt: 271, E():1.7e-12, (41.9% identity in 105 aa overlap). ASSOCIATES WITH NIRB|Rv0252.	Q7U2G1,A0A1R3XUY4	No	intermediary metabolism and respiration			A0A1R3XUY4				IPR012748,IPR017881,IPR017941	Q7U2G1					Rv0253		Rv0253			
NC_002945.3	Mycobrowser_v4	CDS	304150	304674	.	-	0	Mb0260c	cobU		probable bifunctional cobalamin biosynthesis protein cobu: cobinamide kinase + cobinamide phosphate guanylyltransferase	Mb0260c, cobU, len: 174 aa. Equivalent to Rv0254c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Probable cobU,cobalamin biosynthesis protein including a cobinamide kinase (EC 2.-.-.-) and cobinamide phosphate guanylyltransferase (EC 2.-.-.-). Highly similar to many e.g. Q05599|COBU_SALTY COBINAMIDE KINASE / COBINAMIDE PHOSPHATE GUANYLYLTRANSFERASE from Salmonella typhimurium (181 aa), FASTA scores: opt: 308, E(): 1.1e-14, (38.7% identity in 181 aa overlap); P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional cobalamin biosynthesis protein cobU from Escherichia coli strains K12 and O157:H7 (181 aa); part of AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa),FASTA scores: opt: 445, E(): 3.6e-23, (46.0% identity in 176 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U2G0,A0A1R3XVD5	No				A0A1R3XVD5				IPR003203,IPR027417	Q7U2G0										
NC_002945.3	Mycobrowser_v4	CDS	304699	306183	.	-	0	Mb0261c	cobQ1		probable cobyric acid synthase cobq1	Mb0261c, cobQ1, len: 494 aa. Equivalent to Rv0255c,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 494 aa overlap). Probable cobQ1,cobyric acid synthase, similar to many e.g. Z46611|RCBLUGNS_8 COBYRIC ACID SYNTHASE from R.capsulatus (483 aa), FASTA scores: opt: 1239, E(): 0, (47.1% identity in 493 aa overlap); P29932|COBQ_PSEDE COBYRIC ACID SYNTHASE from Pseudomonas denitrificans (484 aa), FASTA scores: opt: 1168, E():0, (44.9% identity in 490 aa overlap); etc. BELONGS TO THE COBB/COBQ FAMILY, COBQ SUBFAMILY. Note that previously known as cobQ.	X2BEI1,P0A533,P0A533	No				P0A533					X2BEI1,P0A533										
NC_002945.3	Mycobrowser_v4	CDS	306202	307872	.	-	0	Mb0262c	PPE2		ppe family protein ppe2	Mb0262c, PPE2, len: 556 aa. Equivalent to Rv0256c,len: 556 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 556 aa overlap). Member of the M. tuberculosis PPE family, similar to many e.g. Rv0280,Rv0286, etc. Equivalent to Z98756|MLCB2492.30 from Mycobacterium leprae (572 aa), FASTA scores: opt: 1837,E(): 0, (62.9% identity in 461 aa overlap).	Q7U2F9,A0A1R3XUS4	No				A0A1R3XUS4				IPR000030	Q7U2F9										
NC_002945.3	Mycobrowser_v4	CDS	311084	312493	.	-	0	Mb0267c	narK3		PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION PROTEIN NARK3 (NITRITE FACILITATOR)	Mb0267c, narK3, len: 469 aa. Equivalent to Rv0261c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable nirK3,nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),equivalent to AAB41700.1|U72744 nitrite extrusion protein from Mycobacterium fortuitum (471 aa); and 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein homolog from Mycobacterium leprae (517 aa; longer in N-terminus). Also similar to other nitrite extrusion proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 755, E(): 0, (35.0% identity in 466 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS.	Q7U2F4,A0A1R3XWZ2	No				A0A1R3XWZ2				IPR011701,IPR016196	Q7U2F4										
NC_002945.3	Mycobrowser_v4	CDS	312634	313179	.	-	0	Mb0268c	aac		AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE AAC (AAC(2')-IC)	Mb0268c, aac, len: 181 aa. Equivalent to Rv0262c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). aac, aminoglycoside 2'-N-acetyltransferase (aac(2')-IC) (EC 2.3.1.-) (see citation below), highly similar to NP_302635.1|NC_002677 aminoglycoside 2'-N-acetyltransferase from Mycobacterium leprae (182 aa); Q49157|AAC2_MYCFO|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium fortuitum (195 aa), FASTA scores: opt: 884, E(): 0, (69.1% identity in 181 aa overlap); and P94968|AAC2_MYCSM|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium smegmatis (210 aa) (see also citation below). Also similar to Q52424|AAC2_PROST AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE from Providencia stuartii (178 aa). BELONGS TO THE AAC(2')-I FAMILY OF ACETYLTRANSFERASES. Note that previously known as aac(2')-IC.	X2BEJ5,P0A5N1,P0A5N1	No				P0A5N1					X2BEJ5,P0A5N1										
NC_002945.3	Mycobrowser_v4	CDS	352850	353140	.	+	0	Mb0296	esxH		low molecular weight protein antigen 7 esxh (10 kda antigen) (cfp-7) (protein tb10.4)	Mb0296, esxH, len: 96 aa. Equivalent to Rv0288,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). esxH (alternate gene name: TB10.4), low molecular weight protein antigen 7 (10 kDa antigen) (CFP-7) (Protein TB10.4) (see citations below), ala-rich protein; member of mycobacterial protein family containing ESAT-6, very similar to MTV012_33 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 566, E(): 0, (84.4% identity in 96 aa overlap). Alternative start codon possible position 351878 (see second citation). BELONG TO THE ESAT6 FAMILY (see first,sixth and seventh citations below).	X2BEL4,P0A569	No	cell wall and cell processes			P0A569					X2BEL4					Rv0288		Rv0288			
NC_002945.3	Mycobrowser_v4	CDS	315850	319479	.	-	0	Mb0272c	oplA		PROBABLE 5-OXOPROLINASE OPLA (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE)	Mb0272c, oplA, len: 1209 aa. Equivalent to Rv0266c,len: 1209 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1209 aa overlap). Probable oplA, 5-oxoprolinase (EC 3.5.2.9), highly similar to others or to hypothetical proteins e.g. AAK24340.1|AE005906 hydantoinase/oxoprolinase from Caulobacter crescentus (1196 aa); NP_103129.1|14022305|BAB48915.1|AP002997 5-oxoprolinase from Mesorhizobium loti (1210 aa); CAC48426.1|AL603642 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (1205 aa); S77037|slr0697|1006579|BAA10729.1|D6400 HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC 6803 (1252 aa), FASTA scores: opt: 2016, E(): 0, (51.4% identity in 1247 aa overlap); P97608|OPLA_RAT|T42756|11278797 5-OXOPROLINASE (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) from Rattus norvegicus (1288 aa); etc. BELONGS TO THE OXOPROLINASE FAMILY.	Q7U2F0,A0A1R3XUT4	No				A0A1R3XUT4				IPR002821,IPR003692,IPR008040	Q7U2F0										
NC_002945.3	Mycobrowser_v4	CDS	319656	321047	.	+	0	Mb0273	narU		probable integral membrane nitrite extrusion protein naru (nitrite facilitator)	Mb0273, narU, len: 463 aa. Equivalent to Rv0267,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Probable narU,nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),similar to other nitrite extrusion proteins e.g. NARU_ECOLI|P37758 nitrite extrusion protein 2 from Escherichia coli (462 aa), FASTA scores: opt: 630, E(): 4.4e-33, (38.9% identity in 463 aa overlap); and NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 607, E(): 1.3e-31, (42.0% identity in 457 aa overlap). Also similar to Rv0261c, Rv2329c, Rv1737c, and to MLCB22_25 from Mycobacterium leprae (517 aa), FASTA score: (35.1 identity in 459 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS.	Q7U2E9,A0A1R3XUT8	No	cell wall and cell processes			A0A1R3XUT8				IPR004737,IPR011701,IPR016196	Q7U2E9					Rv0267		Rv0267			
NC_002945.3	Mycobrowser_v4	CDS	353151	354038	.	+	0	Mb0297	espg3		esx-3 secretion-associated protein espg3	Mb0297, -, len: 295 aa. Equivalent to Rv0289, len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Conserved hypothetical protein, equivalent to CAC32061.1|AL583926 possible DNA-binding protein from Mycobacterium leprae (289 aa); and showing some similarity to Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from Mycobacterium tuberculosis (276 aa), FASTA scores: opt: 149, E(): 0.0035, (27.7% identity in 289 aa overlap).	Q7U2C7,A0A1R3XUW9	No	cell wall and cell processes			A0A1R3XUW9				IPR025734	Q7U2C7					Rv0289		Rv0289			
NC_002945.3	Mycobrowser_v4	CDS	322892	324574	.	+	0	Mb0276	fadD2		PROBABLE FATTY-ACID-COA LIGASE FADD2 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb0276, fadD2, len: 560 aa. Equivalent to Rv0270,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable fadD2,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 544,E(): 2.9e-26, (27.7% identity in 535 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY493_2, MTCY8D5_9, MTCY6G11_8, etc. Contains PS00455 Putative AMP-binding domain signature.	Q7U2E6,A0A1R3XUU7	No				A0A1R3XUU7				IPR000873,IPR020845,IPR025110	Q7U2E6										
NC_002945.3	Mycobrowser_v4	CDS	324591	326786	.	-	0	Mb0277c	fadE6		PROBABLE ACYL-COA DEHYDROGENASE FADE6	Mb0277c, fadE6, len: 731 aa. Equivalent to Rv0271c,len: 731 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 731 aa overlap). Probable fadE6,acyl-CoA dehydrogenase (EC 1.3.99.-), with C-terminal half similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase (short-chain) from Homo sapiens (412 aa),FASTA scores: opt: 339, E(): 1.3e-13, (28.1% identity in 288 aa overlap).	Q7U2E5,A0A1R3XX01	No				A0A1R3XX01				IPR006091,IPR009075,IPR009100,IPR013786	Q7U2E5										
NC_002945.3	Mycobrowser_v4	CDS	331762	332004	.	-	0	Mb0284c	PE_PGRS3b		PE-PGRS FAMILY PROTEIN [SECOND PART]	Mb0284c, PE_PGRS3b, len: 80 aa. Equivalent to 3' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 79 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0,(67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b.		No																			
NC_002945.3	Mycobrowser_v4	CDS	331827	334433	.	-	0	Mb0285c	PE_PGRS3a		PE-PGRS FAMILY PROTEIN [FIRST PART]	Mb0285c, PE_PGRS3a, len: 868 aa. Similar to 5' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (80.7% identity in 888 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b.	Q7U2D8,A0A1R3XUU3	No				A0A1R3XUU3				IPR000084	Q7U2D8										
NC_002945.3	Mycobrowser_v4	tRNA	387234	387304	.	-	0	glyU	glyU		tRNA-Gly	glyU, len: 71 nt. Equivalent to glyU, len: 71 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 nt overlap). tRNA-Gly, anticodon ccc.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1074879	1075553	.	-	0	Mb0987c	lprP		POSSIBLE LIPOPROTEIN LPRP	Mb0987c, lprP, len: 224 aa. Equivalent to Rv0962c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Possible lprP,lipoprotein. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	X2BGC0,P59987,P59987	No				P59987					X2BGC0,P59987										
NC_002945.3	Mycobrowser_v4	CDS	334697	337330	.	-	0	Mb0286c	PE_PGRS3		PE-PGRS FAMILY PROTEIN	Mb0286c, PE_PGRS3, len: 877 aa. Equivalent to Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0,(67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa).	Q7U2D7,A0A1R3XUW6	No				A0A1R3XUW6				IPR000084	Q7U2D7										
NC_002945.3	Mycobrowser_v4	CDS	337580	340075	.	-	0	Mb0287c	PE_PGRS4		pe-pgrs family protein pe_pgrs4	Mb0287c, PE_PGRS4, len: 831 aa. Equivalent to Rv0279c, len: 837 aa, from Mycobacterium tuberculosis strain H37Rv, (97.4% identity in 837 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv0278c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 2677, E(): 0, (64.5% identity in 926 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions each of 9 bp (ccgccggcg-* and cccgccggc-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa).	Q7U2D6,A0A1R3XUV9	No				A0A1R3XUV9				IPR000084	Q7U2D6										
NC_002945.3	Mycobrowser_v4	CDS	340366	341976	.	+	0	Mb0288	PPE3		ppe family protein ppe3	Mb0288, PPE3, len: 536 aa. Equivalent to Rv0280,len: 536 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 536 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium tuberculosis (539 aa), FASTA scores: opt: 1131, E(): 0,(51.7% identity in 540 aa overlap).	Q7U2D5,A0A1R3XX13	No	PE/PPE			A0A1R3XX13				IPR000030	Q7U2D5					Rv0280		Rv0280			
NC_002945.3	Mycobrowser_v4	CDS	343132	345027	.	+	0	Mb0290	ecca3		esx conserved component ecca3. esx-3 type vii secretion system protein.	Mb0290, -, len: 631 aa. Equivalent to Rv0282, len: 631 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 631 aa overlap). Conserved hypothetical protein, similar to Y14967|MLCB628.18c hypothetical protein from Mycobacterium leprae (573 aa), FASTA scores: opt: 916, E(): 0, (38.7% identity in 568 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Z94121|MTY15F10.26 (619 aa), FASTA scores: opt: 743, E(): 0, (29.9% identity in 612 aa overlap). Member of CFXQ,CBXP family - 9 members in Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U2D3,A0A1R3XV16	No	cell wall and cell processes			A0A1R3XV16				IPR000641,IPR003593,IPR003959,IPR023835,IPR027417	Q7U2D3					Rv0282		Rv0282			
NC_002945.3	Mycobrowser_v4	CDS	386203	386973	.	-	0	Mb0325c	glpQ2		possible glycerophosphoryl diester phosphodiesterase glpq2 (glycerophosphodiester phosphodiesterase)	Mb0325c, glpQ2, len: 256 aa. Equivalent to Rv0317c,len: 256 aa (start uncertain, chosen by homology), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 256 aa overlap). Possible glpQ2, glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46), similar to others e.g. E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl diester phosphodiesterase from Deinococcus radiodurans (285 aa); P10908|UGPQ_ECOLI from Escherichia coli (247 aa), FASTA scores: opt: 220, E(): 5.2e-07, (28.0% identity in 250 aa overlap). Also similar to MTCY01A6.27 from Mycobacterium tuberculosis FASTA score: (27.5% identity in 247 aa overlap).	Q7U2A0,A0A1R3XUY6	No				A0A1R3XUY6				IPR004129,IPR017946	Q7U2A0										
NC_002945.3	Mycobrowser_v4	CDS	2196500	2196907	.	-	0	Mb1997c	vapc35		possible toxin vapc35. contains pin domain.	Mb1997c, -, len: 135 aa. Equivalent to Rv1962c,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv3408|MTCY78.20c (133 aa) (36.2% identity in 138 aa overlap); and Rv3384c (130 aa) (43.1% identity in 130 aa overlap)	Q7TZ71,A0A1R3XZT9	No	virulence, detoxification, adaptation			A0A1R3XZT9				IPR002716,IPR022907	Q7TZ71					Rv1962c		Rv1962c			
NC_002945.3	Mycobrowser_v4	CDS	345024	346640	.	+	0	Mb0291	eccb3		esx conserved component eccb3. esx-3 type vii secretion system protein. possible membrane protein.	Mb0291, -, len: 538 aa. Equivalent to Rv0283, len: 538 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 538 aa overlap). Possible conserved membrane protein, similar to several hypothetical mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 698, E(): 0, (37.6% identity in 492 aa overlap); Rv1782; Rv3450c; Rv3869; and Y14967|MLCB628_16|MLCB628.17c from Mycobacterium leprae (481 aa), FASTA scores: opt: 672, E(): 1.5e-31, (37.2% identity in 506 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U2D2,A0A1R3XVF7	No	cell wall and cell processes			A0A1R3XVF7				IPR007795	Q7U2D2					Rv0283		Rv0283			
NC_002945.3	Mycobrowser_v4	CDS	346637	350629	.	+	0	Mb0292	eccc3		esx conserved component eccc3. esx-3 type vii secretion system protein. possible membrane protein.	Mb0292, -, len: 1330 aa. Equivalent to Rv0284, len: 1330 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 1330 aa overlap). Possible conserved membrane protein, similar to products of two adjacent Mycobacterium leprae genes, MLCB628.16c (744 aa) and MLCB628.15c (597 aa); and throughout its length to several large Mycobacterium tuberculosis proteins: Rv3447c,Rv3870, Rv1784, etc. Y14967|MLCB628_ 15 (744 aa), FASTA scores: opt: 942, E(): 0, (33.8% identity in 730 aa overlap); Y14967|MLCB628_14 (597 aa), FASTA scores: opt: 613, E(): 3.1e-30, (31.7% identity in 615 aa overlap); Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap); Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap). Contains three PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U2D1,A0A1R3XUW2	No	cell wall and cell processes			A0A1R3XUW2				IPR002543,IPR003593,IPR023836,IPR023837,IPR027417	Q7U2D1					Rv0284		Rv0284			
NC_002945.3	Mycobrowser_v4	CDS	350626	350934	.	+	0	Mb0293	PE5		pe family protein pe5	Mb0293, PE5, len: 102 aa. Equivalent to Rv0285,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below), similar to others e.g. AL0212|MTV012_37 from Mycobacterium tuberculosis (105 aa), FASTA scores: opt: 497, E(): 2.6e-24, (80.4% identity in 102 aa overlap); Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity in 102 aa overlap); etc.	Q7U2D0,A0A1R3XUV2	No	PE/PPE			A0A1R3XUV2				IPR000084	Q7U2D0					Rv0285		Rv0285			
NC_002945.3	Mycobrowser_v4	CDS	350937	352478	.	+	0	Mb0294	PPE4		ppe family protein ppe4	Mb0294, PPE4, len: 513 aa. Equivalent to Rv0286,len: 513 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 513 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 958, E(): 0, (43.5% identity in 522 aa overlap).	Q7U2C9,A0A1R3XUW0	No	PE/PPE			A0A1R3XUW0				IPR000030	Q7U2C9					Rv0286		Rv0286			
NC_002945.3	Mycobrowser_v4	CDS	352527	352820	.	+	0	Mb0295	esxG		esat-6 like protein esxg (conserved protein tb9.8)	Mb0295, esxG, len: 97 aa. Equivalent to Rv0287,len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). esxG, conserved hypothetical protein. PE-family related protein; distant member of the Mycobacterium tuberculosis PE family,similar to Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt: 564, E(): 0, (91.8% identity in 97 aa overlap). Contains probable helix-turn-helix motif at aa 14-35 (Score 144, +4.11 SD). SEEMS TO BELONG TO THE ESAT6 FAMILY (see third citation below).	Q7U2C8,A0A1R3XUV4	No	cell wall and cell processes			A0A1R3XUV4				IPR010310	Q7U2C8					Rv0287		Rv0287			
NC_002945.3	Mycobrowser_v4	CDS	354085	355503	.	+	0	Mb0298	eccd3		esx conserved component eccd3. esx-3 type vii secretion system protein. probable transmembrane protein.	Mb0298, -, len: 472 aa. Equivalent to Rv0290, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable conserved transmembrane protein, similar to several others in mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from Mycobacterium tuberculosis (467 aa), FASTA scores: opt: 429, E(): 5.1e-19, (28. 6% identity in 479 aa overlap); Rv3877; Rv1795; Rv3448; and Y14967|MLCB628_9|MLCB628.10c from Mycobacterium leprae (480 aa), FASTA scores: opt: 269, E(): 3.1e-09, (26.0% identity in 503 aa overlap). TBparse score is 0.892.	Q7U2C6,A0A1R3XX22	No	cell wall and cell processes			A0A1R3XX22				IPR006707,IPR024962	Q7U2C6					Rv0290		Rv0290			
NC_002945.3	Mycobrowser_v4	CDS	355500	356885	.	+	0	Mb0299	mycp3		probable membrane-anchored mycosin mycp3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	Mb0299, -, len: 461 aa. Equivalent to Rv0291, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable protease precursor (EC 3.4.-.-), similar to several others in mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from Mycobacterium leprae (446 aa), FASTA scores: opt: 1159,E(): 0, (43.5 identity in 446 aa overlap). Has signal sequence and hydrophobic stretch at C-terminus, followed by short positively charged segment, that could act as membrane anchor. Shows similarity to several members of the subtilase family and contains PS00137 Serine proteases, subtilase family, histidine active site signature.	Q7U2C5,A0A1R3XVZ9	No	intermediary metabolism and respiration			A0A1R3XVZ9				IPR000209,IPR015500,IPR022398,IPR023834	Q7U2C5					Rv0291		Rv0291			
NC_002945.3	Mycobrowser_v4	CDS	356882	357877	.	+	0	Mb0300	ecce3		esx conserved component ecce3. esx-3 type vii secretion system protein. probable transmembrane protein.	Mb0300, -, len: 331 aa. Equivalent to Rv0292, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 331 aa overlap). Probable conserved transmembrane protein (has two hydrophobic segments at N-terminal end), equivalent to CAC32058.1|AL583926 conserved membrane protein from Mycobacterium leprae (339 aa).	Q7U2C4,A0A1R3XV28	No	cell wall and cell processes			A0A1R3XV28				IPR021368	Q7U2C4					Rv0292		Rv0292			
NC_002945.3	Mycobrowser_v4	CDS	359173	359958	.	+	0	Mb0302	tam		PROBABLE TRANS-ACONITATE METHYLTRANSFERASE TAM	Mb0302, tam, len: 261 aa. Equivalent to Rv0294,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 261 aa overlap). Probable tam,trans-aconitate methyltransferase (EC 2.1.1.-), similar to others e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 TRANS-ACONITATE METHYLTRANSFERASE from Escherichia coli strain K12 (252 aa), FASTA scores: opt: 649, E(): 0, (39.3 identity in 252 aa overlap). BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY.	X2BEL6,P66886,P66886	No	intermediary metabolism and respiration			P66886					X2BEL6,P66886					Rv0294		Rv0294			
NC_002945.3	Mycobrowser_v4	CDS	362336	364156	.	+	0	Mb0305	PE_PGRS5		pe-pgrs family protein pe_pgrs5	Mb0305, PE_PGRS5, len: 606 aa. Equivalent to Rv0297, len: 591 aa, from Mycobacterium tuberculosis strain H37Rv, (97.5% identity in 606 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Y03A_MYCTU|Q10637 from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 1884, E(): 0, (53.7% identity in 635 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa).	Q7U2C0,A0A1R3XUW3	No	PE/PPE			A0A1R3XUW3				IPR000084	Q7U2C0					Rv0297		Rv0297			
NC_002945.3	Mycobrowser_v4	CDS	370784	376741	.	-	0	Mb0313c	PPE6		ppe family protein ppe6	Mb0313c, PPE6, len: 1985 aa. Equivalent to 5' end of Rv0305c, len: 963 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 809 aa overlap). Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Y04H_MYCTU|Q10778 from M. tuberculosis (734 aa), FASTA scores: opt: 1340, E(): 0,(40.9% identity in 815 aa overlap); Z95324|MTY13E10_16 from Mycobacterium tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0, (42.3% identity in 522 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis, a single base deletion (t-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5.	Q7U2B2,A0A1R3XUX5	No				A0A1R3XUX5				IPR000030,IPR002989	Q7U2B2										
NC_002945.3	Mycobrowser_v4	CDS	390290	391621	.	+	0	Mb0330	udgA		PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH)	Mb0330, udgA, len: 443 aa. Equivalent to Rv0322,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 443 aa overlap). Probable udg (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase (EC 1.1.1.22), highly similar to others e.g. CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase from Streptomyces coelicolor (447 aa); Q56812 UDP-GLUCOSE DEHYDROGENASE from Xanthomonas campestris (445 aa), FASTA scores: opt: 713, E(): 0, (41.9% identity in 351 aa overlap); etc. Also similar to several GDP-mannose 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UDP-GLUCOSE/GDP-MANNOSE DEHYDROGENASES FAMILY.	Q7U296,A0A1R3XV64	No	intermediary metabolism and respiration			A0A1R3XV64				IPR001732,IPR008927,IPR014026,IPR014027,IPR016040,IPR017476,IPR028357	Q7U296					Rv0322		Rv0322			
NC_002945.3	Mycobrowser_v4	CDS	388178	388846	.	+	0	Mb0327	pcp		PROBABLE PYRROLIDONE-CARBOXYLATE PEPTIDASE PCP (5-OXOPROLYL-PEPTIDASE) (PYROGLUTAMYL-PEPTIDASE I) (PGP-I) (PYRASE)	Mb0327, pcp, len: 222 aa. Equivalent to Rv0319,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable pcp,pyrrolidone-carboxylate peptidase (EC 3.4.19.3), highly similar to others e.g. PCP_PSEFL|P42673 pyrrolidone-carboxylate peptidase from Pseudomonas fluorescens (213 aa), FASTA scores: opt: 478, E(): 7.5e-25, (40.2% identity in 219 aa overlap). BELONGS TO PEPTIDASE FAMILY C15 (THIOL PROTEASE).	X2BEP1,P0A5R5,P0A5R5	No	intermediary metabolism and respiration			P0A5R5					X2BEP1,P0A5R5					Rv0319		Rv0319			
NC_002945.3	Mycobrowser_v4	CDS	415411	415971	.	-	0	Mb0351c	lpqJ		PROBABLE LIPOPROTEIN LPQJ	Mb0351c, lpqJ, len: 186 aa. Equivalent to Rv0344c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 186 aa overlap). Probable lipoprotein,without homology. Has an appropriately positioned prokaryotic lipoprotein signature (PS00013).	Q7U277,A0A1R3XVL3	No				A0A1R3XVL3					Q7U277										
NC_002945.3	Mycobrowser_v4	CDS	389612	390184	.	+	0	Mb0329	dcd		PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	Mb0329, dcd, len: 190 aa. Equivalent to Rv0321,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 190 aa overlap). Probable dcd (alterrnate gene names: dus or paxA), deoxycytidine triphosphate deaminase (EC 3.5.4.13), equivalent to CAC32024.1|AL583925 probable deoxycytidine triphosphate deaminase from Mycobacterium leprae (190 aa). Also highly similar to others e.g. Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE from Streptomyces coelicolor (191 aa); DCD_ECOLI|P28248|DUS|PAXA|B2065 DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE from Escherichia coli strain K12 (193 aa), FASTA scores: opt: 408, E(): 2.7e-21, (43.1% identity in 188 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE DCTP DEAMINASE FAMILY.	X2BEL5,Q7U297,Q7U297	No	intermediary metabolism and respiration			Q7U297					X2BEL5,Q7U297					Rv0321		Rv0321			
NC_002945.3	Mycobrowser_v4	CDS	393726	395075	.	-	0	Mb0334c	cyp135A1		POSSIBLE CYTOCHROME P450 135A1 CYP135A1	Mb0334c, cyp135A1, len: 449 aa. Equivalent to Rv0327c, len: 449 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 449 aa overlap). Possible cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() : 1.7e-11, (27.9% identity in 433 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in 434 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. Alternative start possible at 33706 but no RBS.	Q7U292,A0A1R3XV04	No				A0A1R3XV04				IPR001128,IPR002401,IPR017972	Q7U292										
NC_002945.3	Mycobrowser_v4	CDS	399688	400554	.	+	0	Mb0341	rmlA		alpha-d-glucose-1-phosphate thymidylyltransferase rmla (dtdp-glucose synthase) (dtdp-glucose pyrophosphorylase)	Mb0341, rmlA, len: 288 aa. Equivalent to Rv0334,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 288 aa overlap). Probable rmlA (alternate gene name: rfbA), glucose-1-phosphate thymidylyl-transferase (EC 2.7.7.24), equivalent to CAC32020.1|AL583925 glucose-1-phosphate thymidyltransferase from Mycobacterium leprae (288 aa). Also highly similar to others e.g. AAG29804.1|AF235050 glucose-1-phosphate thymidylyltransferase from Streptomyces rishiriensis (296 aa); RBA1_ECOLI|P37744 glucose-1-phosphate thymidylyltransferase from Escherichia coli strain K12 (293 aa), FASTA scores: opt: 1199, E(): 0,(62.0% identity in 284 aa overlap). BELONGS TO THE GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE FAMILY.	Q7U285,A0A1R3XVJ8	No	intermediary metabolism and respiration			A0A1R3XVJ8				IPR005835,IPR005907	Q7U285					Rv0334		Rv0334			
NC_002945.3	Mycobrowser_v4	CDS	402903	404192	.	-	0	Mb0344c	aspC		PROBABLE ASPARTATE AMINOTRANSFERASE ASPC (TRANSAMINASE A) (ASPAT)	Mb0344c, aspC, len: 429 aa. Equivalent to Rv0337c,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Probable aspC,aspartate aminotransferase (transaminase A) (EC 2.6.1.1),equivalent to CAC32019.1|AL583925 probable aspartate aminotransferase from Mycobacterium leprae (437 aa). Also highly similar to many e.g. Q48143|U32823 aspartate aminotransferase (404 aa), FASTA scores: opt: 1646, E(): 0, (57.2% identity in 404 aa overlap). Also some similarity to Rv3565|MTCY06G11.12 from Mycobacterium tuberculosis FASTA score: (27.2% identity in 383 aa overlap). BELONGS TO CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE.	X2BEM9,P63499,P63499	No				P63499					X2BEM9,P63499										
NC_002945.3	Mycobrowser_v4	CDS	1021810	1022109	.	-	0	Mb0940c	PE7		pe family protein pe7	Mb0940c, PE7, len: 99 aa. Equivalent to Rv0916c,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many e.g. Rv1788 from Mycobacterium tuberculosis (99 aa), FASTA scores: opt: 321, E(): 1.3e-11, (53.5% identity in 99 aa overlap); etc.	Q7U113,A0A1R3XWS4	No	PE/PPE			A0A1R3XWS4				IPR000084	Q7U113					Rv0916c		Rv0916c			
NC_002945.3	Mycobrowser_v4	CDS	410392	411831	.	+	0	Mb0348	iniB		ISONIAZID INDUCTIBLE GENE PROTEIN INIB	Mb0348, iniB, len: 479 aa. Equivalent to Rv0341,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). iniB,isoniazid-inducible gene, (see citations below). Protein very Gly-, Ala-rich, similar to cell wall proteins e.g. P27483|GRP_ARATH GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN from A.thaliana (338 aa), FASTA scores: opt: 532, E(): 5.2e-13, (39.3% identity in 321 aa overlap). MEME-MAST analysis shows similarity to product of upstream gene,Rv0340.	Q7U280,A0A1R3XX70	No	cell wall and cell processes			A0A1R3XX70					Q7U280					Rv0341		Rv0341			
NC_002945.3	Mycobrowser_v4	CDS	411868	413790	.	+	0	Mb0349	iniA		ISONIAZID INDUCTIBLE GENE PROTEIN INIA	Mb0349, iniA, len: 640 aa. Equivalent to Rv0342,len: 640 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 640 aa overlap). iniA,isoniazid-inducible gene, (see citations below). Shows slight similarity to some hypothetical bacterial proteins e.g. P40983|YOR6_THER hypothetical protein (402 aa), FASTA scores: opt: 242, E(): 1.4e-07, (22.3% identity in 349 aa overlap). Also some similarity to downstream ORF Rv0343|iniC. Possible transmembrane stretch around residue 490. Alternative translational start at 410824. Contains a phosphopantetheine attachment site motif suggestive of an acyl carrier protein. Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.	Q7U279,A0A1R3XW50	No	cell wall and cell processes			A0A1R3XW50				IPR001401,IPR027417	Q7U279					Rv0342		Rv0342			
NC_002945.3	Mycobrowser_v4	CDS	413787	415268	.	+	0	Mb0350	iniC		ISONIAZID INDUCTIBLE GENE PROTEIN INIC	Mb0350, iniC, len: 493 aa. Equivalent to Rv0343,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 493 aa overlap). iniC,isoniazid-inducible gene, (see citations below). Shows slight similarity to P40983|YOR6_THER8 hypothetical protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05,(25.9% identity in 228 aa overlap). Also some similarity to upstream ORF Rv0342|iniA. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.	Q7U278,A0A1R3XV86	No	cell wall and cell processes			A0A1R3XV86				IPR001401,IPR027417	Q7U278					Rv0343		Rv0343			
NC_002945.3	Mycobrowser_v4	CDS	416531	417994	.	-	0	Mb0354c	ansP2		POSSIBLE L-ASPARAGINE PERMEASE ANSP2 (L-ASPARAGINE TRANSPORT PROTEIN)	Mb0354c, ansP2, len: 487 aa. Equivalent to Rv0346c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 487 aa overlap). Possible ansP2,L-asparagine permease, integral membrane protein belonging to family containing many amino acid permeases, highly similar to G467030|B2126_F2_85|NP_301937.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (498 aa); and NP_301938.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (505 aa). Also highly similar to others e.g. P77610|ANSP_ECOLI L-ASPARAGINE PERMEASE from Escherichia coli strain K-12 (499 aa). Also highly similar to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 PROBABLE L-ASPARAGINE PERMEASE from Mycobacterium tuberculosis (489 aa), FASTA score: (72.1% identity in 473 aa overlap). And shows some similarity to MTCY3G12.14 from Mycobacterium tuberculosis. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Note that previously known as aroP2.	X2BES8,P0A4W1,P0A4W1	No				P0A4W1					X2BES8,P0A4W1										
NC_002945.3	Mycobrowser_v4	CDS	420864	422741	.	+	0	Mb0358	dnaK		PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70)	Mb0358, dnaK, len: 625 aa. Equivalent to Rv0350,len: 625 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 625 aa overlap). Probable DnaK (alternate gene name: hsp70), 70 kDa heat shock protein (see citations below), equivalent to AAA25362.1|M95576|1924344A|738248 heat shock protein 70 from Mycobacterium leprae (621 aa); and DNAK_MYCPA|Q00488 (623 aa), FASTA scores: opt: 3678, E(): 0, (92.3% identity in 625 aa overlap). Also highly similar to others e.g. Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 CHAPERONE PROTEIN DNAK from Streptomyces coelicolor (618 aa). Has probably an ATPase activity (EC 3.6.1.-). Note that this sequence differs from DNAK_MYCTU|P32723 (609 aa), due to a frameshift near the N-terminus. BELONGS TO THE HEAT SHOCK PROTEIN 70 FAMILY.	X2BES1,P0A5C0,P0A5C0	No	virulence, detoxification, adaptation			P0A5C0					X2BES1,P0A5C0					Rv0350		Rv0350			
NC_002945.3	Mycobrowser_v4	CDS	422738	423445	.	+	0	Mb0359	grpE		PROBABLE GRPE PROTEIN (HSP-70 COFACTOR)	Mb0359, grpE, len: 235 aa. Equivalent to Rv0351,len: 235 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 235 aa overlap). Probable grpE protein (HSP-70 COFACTOR), equivalent to CAC32012.1|AL583925 Hsp70 cofactor from Mycobacterium leprae (229 aa). Also highly similar to others eg Q05562|GRPE_STRCO|2127521|PN0643 GRPE PROTEIN from Streptomyces coelicolor (225 aa). Contains grpE protein signature (PS01071). BELONGS TO THE GRPE FAMILY.	X2BET3,Q7U272,Q7U272	No	virulence, detoxification, adaptation			Q7U272					X2BET3,Q7U272					Rv0351		Rv0351			
NC_002945.3	Mycobrowser_v4	CDS	423481	424668	.	+	0	Mb0360	dnaJ1		PROBABLE CHAPERONE PROTEIN DNAJ1	Mb0360, dnaJ1, len: 395 aa. Equivalent to Rv0352,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 395 aa overlap). Probable DnaJ1,chaperone protein, equivalent to AAA25363.1|M95576 DNA J heatshock protein from Mycobacterium leprae (389 aa). Also highly similar to others. Contains both DnaJ signatures (PS00636, and PS00637). BELONGS TO THE DNAJ FAMILY. COFACTOR: BINDS TWO ZINC IONS PER MONOMER. Note that sequence differs from DNAJ_MYCTU|P07881 due to a frameshift at the N-terminus. Note that previously known as dnaJ.	X2BEP4,P0A549,P0A549	No				P0A549					X2BEP4,P0A549										
NC_002945.3	Mycobrowser_v4	CDS	424668	425048	.	+	0	Mb0361	hspR		probable heat shock protein transcriptional repressor hspr (merr family)	Mb0361, hspR, len: 126 aa. Equivalent to Rv0353,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Probable hspR, heat shock regulatory protein, merR family, highly similar to others e.g. HspR|P40183 heat shock regulatory protein from Streptomyces coelicolor (151 aa), FASTA scores: E(): 4.9e-22, (55.7% identity in 140 aa overlap), that binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon. Has possible coiled coil region in C-terminal half. BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7U271,A0A1R3XV98	No	virulence, detoxification, adaptation			A0A1R3XV98				IPR000551,IPR009061	Q7U271					Rv0353		Rv0353			
NC_002945.3	Mycobrowser_v4	CDS	425173	435696	.	-	0	Mb0362c	PPE8		ppe family protein ppe7	Mb0362c, PPE8, len: 3507 aa. Equivalent to Rv0355c and Rv0354c, len: 3300 aa and 141 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 3296 aa overlap and 100.0% identity in 125 aa overlap). PPE8,member of the Mycobacterium tuberculosis PPE family,similar to others e.g. AL009198|MTV004_5 from M. tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0,(40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17, E(): 0; MTCY98.0034c,E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; MTCY31.06c, E(): 5.6e-17; MTCY359.33, E(): 2.3e-16. PPE7,member of the Mycobacterium tuberculosis PPE family,similar to others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa), FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa overlap). Possible continuation of ORF upstream, but no sequence error apparent. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis, a 2 bp insertion (*-ta) resulting in the absence of a stop codon between the 2 genes, leads to a single product.	Q7U270,A0A1R3XVM3	No	PE/PPE			A0A1R3XVM3				IPR000030,IPR002989	Q7U270					Rv0355c		Rv0355c			
NC_002945.3	Mycobrowser_v4	CDS	436488	437786	.	-	0	Mb0364c	purA		PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)	Mb0364c, purA, len: 432 aa. Equivalent to Rv0357c,len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Probable purA,adenylosuccinate synthase (EC 6.3.4.4), equivalent to AL023514|MLCB4_13 from ADENYLOSUCCINATE SYNTHETASE Mycobacterium leprae (432 aa), FASTA scores: opt: 2555,E(): 0, (87.9% identity in 431 aa overlap). Also highly similar to many bacterial adenylosuccinates synthetases e.g. P12283|PURA_ECOLI adenylosuccinates synthetase from Escherichia coli (431 aa), FASTA scores: E(): 0, (51.1% identity in 425 aa overlap); etc. BELONGS TO THE ADENYLOSUCCINATE SYNTHETASE FAMILY.	X2BET8,P65881,P65881	No				P65881					X2BET8,P65881										
NC_002945.3	Mycobrowser_v4	CDS	440888	442270	.	+	0	Mb0369	mgtE		POSSIBLE Mg2+ TRANSPORT TRANSMEMBRANE PROTEIN MGTE	Mb0369, mgtE, len: 460 aa. Equivalent to Rv0362,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 460 aa overlap). Possible mgtE,magnesium (Mg2+) transport transmembrane protein; C-terminal region is highly similar to MGTE|G780283 putative Mg2+ transporter from Providencia stuarti (314 aa), FASTA scores: E(): 0, (47.2% identity in 307 aa overlap) (N-terminus extends approx. 150 aa further upstream compared to P. stuarti ORF). Also similar in part to others e.g. AAK20879.1|AF334760_1|AF334760 putative Mg2+ transporter from Aeromonas hydrophila (455 aa); NP_231292.1|NC_002505 magnesium transporter from Vibrio cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport protein from Mesorhizobium loti (454 aa); etc. Also similar to Rv1232c|MTV006.04c from Mycobacterium tuberculosis (435 aa). Extended hydrophobic segment spanning last 130 residues. BELONG TO THE MGTE FAMILY.	Q7U264,A0A1R3XX91	No	cell wall and cell processes			A0A1R3XX91				IPR000644,IPR006667,IPR006668,IPR006669	Q7U264					Rv0362		Rv0362			
NC_002945.3	Mycobrowser_v4	CDS	442282	443316	.	-	0	Mb0370c	fba		PROBABLE FRUCTOSE-BISPHOSPHATE ALDOLASE FBA	Mb0370c, fba, len: 344 aa. Equivalent to Rv0363c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable fba (alternate gene name: fda), fructose bisphosphate aldolase (EC 4.1.2.13), equivalent to AL023514|MLCB4_18|O69600|ALF_MYCLE FRUCTOSE-BISPHOSPHATE ALDOLASE from Mycobacterium leprae (345 aa), FASTA scores: opt: 1995, E(): 0, (87.7% identity in 342 aa overlap). Also highly similar to others. BELONGS TO CLASS II FRUCTOSE-BISPHOSPHATE ALDOLASE FAMILY. COFACTOR: ZINC.	X2BEQ4,P67476,P67476	No				P67476					X2BEQ4,P67476										
NC_002945.3	Mycobrowser_v4	CDS	500732	501385	.	+	0	Mb0421	mutT3		POSSIBLE MUTATOR PROTEIN MUTT3 (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE) (8-OXO-DGTPASE) (DGTP PYROPHOSPHOHYDROLASE)	Mb0421, mutT3, len: 217 aa. Equivalent to Rv0413,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Possible mutT3,mutator protein (EC 3.6.1.-), showing some similarity with e.g. MUTT_PROVU|P32090 mutator mutt protein from Proteus vulgaris (112 aa), FASTA scores: opt: 151, E(): 0.0008,(40.7% identity in 59 aa overlap). SEEMS TO BELONG TO THE NUDIX HYDROLASE FAMILY.	Q7U218,A0A1R3XVU3	No				A0A1R3XVU3				IPR000086,IPR015797,IPR020084,IPR020476	Q7U218										
NC_002945.3	Mycobrowser_v4	CDS	456994	457209	.	+	0	Mb0386	secE2		POSSIBLE PROTEIN TRANSPORT PROTEIN SECE2	Mb0386, secE2, len: 71 aa. Equivalent to Rv0379,len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Possible secE2,protein transport protein, showing similarity with P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: 79, E(): 4.7. (30.3% identity in 66 aa overlap); and hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (71 aa); etc. Also highly similar to U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis protein from a patient isolate (116 aa), FASTA scores: opt: 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). Note that for Rv0379|MTV036.14, a translation initiation region different to the one in U85467|MTU85467_1 was chosen. COULD BE A PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c,SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732.	Q7U248,A0A1R3XV50	No	cell wall and cell processes			A0A1R3XV50				IPR009923,IPR025543	Q7U248					Rv0379		Rv0379			
NC_002945.3	Mycobrowser_v4	CDS	458858	459397	.	-	0	Mb0389c	pyrE		PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	Mb0389c, pyrE, len: 179 aa. Equivalent to Rv0382c,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable pyrE,orotate phosphoribosyltransferase (EC 2.4.2.10),equivalent to CAC32004.1|AL583925 probable purine/pyrimidine phosphoribosyltransferase from Mycobacterium leprae (179 aa). Also highly similar to many others e.g. T36540|4753874|CAB42037.1|AL049754|SCH10.28c probable orotate phosphoribosyltransferase from Streptomyces coelicolor (182 aa); H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable orotate phosphoribosyltransferase from Methanobacterium thermoautotrophicum (180 aa), FASTA scores: opt: 389, E(): 2.7e-20, (40.7% identity in 172 aa overlap); O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 OROTATE PHOSPHORIBOSYLTRANSFERASE from Sulfolobus acidocaldarius (197 aa); etc. Note that also similar to other puridine 5'-monophosphate synthases (umpA genes; UMP synthases),generally in N-terminus that corresponds to orotate phosphoribosyltransferase activity. Contains PS00589 PTS HPR component serine phosphorylation site signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. Note that previously known as umpA.	X2BEW3,P0A5U1,P0A5U1	No				P0A5U1					X2BEW3,P0A5U1										
NC_002945.3	Mycobrowser_v4	CDS	460473	463019	.	-	0	Mb0391c	clpB		PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1)	Mb0391c, clpB, len: 848 aa. Equivalent to Rv0384c,len: 848 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 848 aa overlap). Probable clpB (alternate gene name: htpM), endopeptidase ATP-binding protein, chain B (EC 3.-.-.-), equivalent to AC32007.1|AL583925 heat shock protein from Mycobacterium leprae (848 aa). Also highly similar to others e.g. P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB PROTEIN (heat-inducible expression) from Corynebacterium glutamicum (852 aa), FASTA scores: opt: 4113, E(): 0, (74.5% identity in 846 aa overlap); T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c probable ATP-dependent proteinase ATP-binding chain from Streptomyces coelicolor (853 aa); P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains K12 and O157:H7 (857 aa); etc. Also similar to Rv3596c|ClpC from Mycobacterium tuberculosis. Contains PS00870 and PS00871 Chaperonins clpA/B signatures and two PS000017 ATP/GTP-binding site motives A (P-loop). BELONGS TO THE CLPA/CLPB FAMILY. Contains probable coiled-coil domain from aa 411-503.	X2BEW5,P63287,P63287	No				P63287					X2BEW5,P63287										
NC_002945.3	Mycobrowser_v4	CDS	503186	503392	.	+	0	Mb0424	thiS		POSSIBLE PROTEIN THIS	Mb0424, thiS, len: 68 aa. Equivalent to Rv0416,len: 68 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 68 aa overlap). Possible thiS protein,equivalent to T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 hypothetical protein from Mycobacterium leprae (74 aa),FASTA scores: opt: 303, E(): 2e-18, (71.6% identity in 74 aa overlap). Shows weak similarity with O32583|THIS_ECOLI|THIG1|B3991.1 THIS PROTEIN from Escherichia coli strain K12 (66 aa), FASTA scores: opt: 103, E(): 0.052, (30.9% identity in 68 aa overlap).	Q7U216,A0A1R3XV92	No	intermediary metabolism and respiration			A0A1R3XV92				IPR003749,IPR010035,IPR012675,IPR016155	Q7U216					Rv0416		Rv0416			
NC_002945.3	Mycobrowser_v4	CDS	467689	469020	.	-	0	Mb0394c	PPE9		conserved hypothetical protein	Mb0394c, PPE9, len: 443 aa. Equivalent to Rv0388c and Rv0387c, len: 180 aa and 244 aa, from Mycobacterium tuberculosis strain H37Rv, (95.1% identity in 164 aa overlap and 100.0% identity in 244 aa overlap). Rv0388c: Member of the Mycobacterium tuberculosis PPE family,highly similar to others e.g. MTCY10G2_10|Z92539 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 667, E(): 0, (58.3% identity in 180 aa overlap) but much shorter. Rv0387c: conserved hypothetical protein, showing some similarity to MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon 1, Elastin (687 aa), FASTA scores: opt: 193, E(): 0.35, (34.4% identity in 189 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (tctacagt-gctacagg), and lastly of 28 bases, leads to a longer single product.	Q7U242,A0A1R3XV71	No	PE/PPE			A0A1R3XV71				IPR000030,IPR022171	Q7U242					Rv0388c		Rv0388c			
NC_002945.3	Mycobrowser_v4	CDS	469354	470613	.	+	0	Mb0395	purT		PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) (FORMATE-DEPENDENT GAR TRANSFORMYLASE)	Mb0395, purT, len: 419 aa. Equivalent to Rv0389,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 419 aa overlap). Probable purT,phosphoribosylglycinamide formyltransferase 2 (EC 2.1.2.-), similar to others e.g. P33221|PURT_ECOLI|B1849 phosphoribosylglycinamide formyltransferase 2 from Escherichia coli strain K-12 (391 aa), FASTA scores: opt: 481, E(): 1.3e-22, (40.1% identity in 379 aa overlap); etc. BELONGS TO THE PURK / PURT FAMILY. COFACTOR: MAGNESIUM.	Q7U241,A0A1R3XV63	No	intermediary metabolism and respiration			A0A1R3XV63				IPR003135,IPR005862,IPR011761,IPR013815,IPR013816,IPR016185	Q7U241					Rv0389		Rv0389			
NC_002945.3	Mycobrowser_v4	CDS	471029	472249	.	+	0	Mb0397	metZ		PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ (OSH SULFHYDRYLASE)	Mb0397, metZ, len: 406 aa. Equivalent to Rv0391,len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable metZ,O-succinylhomoserine sulfhydrylase (EC 4.2.99.-),equivalent, but shorter 20 aa in N-terminus, to AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from Mycobacterium leprae (426 aa). Also highly similar to others e.g. METZ_PSEAE|P55218 o-succinylhomoserine sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA scores: opt: 1175, E(): 0, (47.2% identity in 392 aa overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. Could also be a cystathionine gamma-synthase (EC 4.2.99.9).	Q7U239,A0A1R3XV74	No	intermediary metabolism and respiration			A0A1R3XV74				IPR000277,IPR006234,IPR015421,IPR015422,IPR015424	Q7U239					Rv0391		Rv0391			
NC_002945.3	Mycobrowser_v4	CDS	472246	473658	.	-	0	Mb0398c	ndhA		PROBABLE MEMBRANE NADH DEHYDROGENASE NDHA	Mb0398c, ndhA, len: 470 aa. Equivalent to Rv0392c,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 470 aa overlap). Probable ndhA,membrane NADH dehydrogenase (EC 1.6.99.3), equivalent to many e.g. AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium smegmatis (457 aa), FASTA scores: opt: 1991,E(): 0, (67.9% identity in 458 aa overlap); MLCB1788_3 NADH dehydrogenase from Mycobacterium leprae (466 aa),FASTA score: (62.5% identity in 467 aa overlap). Also similar to others from several organisms e.g. P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH DEHYDROGENASE from Escherichia coli (434 aa); and Rv0392c|ndhB from Mycobacterium tuberculosis. Has hydrophobic stretch in C-terminus. BELONGS TO THE NADH DEHYDROGENASE FAMILY.	Q7U238,A0A1R3XV68	No				A0A1R3XV68				IPR001327,IPR013027,IPR023753	Q7U238										
NC_002945.3	Mycobrowser_v4	CDS	478346	479575	.	-	0	Mb0405c	lpqK		POSSIBLE CONSERVED LIPOPROTEIN LPQK	Mb0405c, lpqK, len: 409 aa. Equivalent to Rv0399c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Possible lpqK,conserved lipoprotein, showing some similarity to penicillin binding proteins and various peptidases e.g. DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase protein (406 aa), FASTA scores: opt: 348, E(): 5.6e-16,(29.2% identity in 301 aa overlap). Also similar to other Mycobacterium tuberculosis PBPs and esterases. Has possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).	Q7U231,A0A1R3XV70	No				A0A1R3XV70				IPR001466,IPR012338	Q7U231										
NC_002945.3	Mycobrowser_v4	CDS	479585	480772	.	-	0	Mb0406c	fadE7		acyl-coa dehydrogenase fade7	Mb0406c, fadE7, len: 395 aa. Equivalent to Rv0400c,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 395 aa overlap). Probable fadE7,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. CAC12923.1|AL445403 putative acyl CoA dehydrogenase from Streptomyces coelicolor (397 aa); G624219 GLUTARYL-COA DEHYDROGENASE PRECURSOR (438 aa), FASTA scores: opt: 1161,E(): 0, (48.1% identity in 391 aa overlap); etc.	Q7U230,A0A1R3XV77	No				A0A1R3XV77				IPR006091,IPR009075,IPR009100,IPR013786	Q7U230										
NC_002945.3	Mycobrowser_v4	CDS	481374	482477	.	-	0	Mb0408c	mmpL1b		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL1B [SECOND PART]	Mb0408c, mmpL1b, len: 367 aa. Equivalent to 3' end of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 367 aa overlap). Probable mmpL1, conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kd membrane protein from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0, (55.4% identity in 933aa overlap); YV34_MYCLE|P54881 hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3615,E(): 0, (55.5% identity in 941 aa overlap); etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and M. leprae e.g. Rv0450c,Rv0676c, Rv0507, etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b.	Q7U228,A0A1R3XXE1	No				A0A1R3XXE1				IPR004869	Q7U228										
NC_002945.3	Mycobrowser_v4	CDS	482474	484249	.	-	0	Mb0409c	mmpL1a		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL1A [FIRST PART]	Mb0409c, mmpL1a, len: 591 aa. Equivalent to 5' end of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 568 aa overlap). Probable mmpL1, conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kd membrane protein from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0,(55.4% identity in 933aa overlap); YV34_MYCLE|P54881 hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3615, E(): 0, (55.5% identity in 941 aa overlap); etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and M. leprae e.g. Rv0450c, Rv0676c, Rv0507,etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b.	Q7U227,A0A1R3XWC4	No				A0A1R3XWC4				IPR004869	Q7U227										
NC_002945.3	Mycobrowser_v4	CDS	484246	484674	.	-	0	Mb0410c	mmpS1		PROBABLE CONSERVED MEMBRANE PROTEIN MMPS1	Mb0410c, mmpS1, len: 142 aa. Equivalent to Rv0403c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable mmpS1,conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. YV33_MYCLE|P54880 hypothetical 16.9 kd protein from Mycobacterium leprae (154 aa), FASTA scores: opt: 458,E(): 1.6e-26, (46.9% identity in 143 aa overlap); YV33_MYCTU|Q11170 hypothetical 15 .9 kd protein from M. tuberculosis (147 aa), FASTA scores: opt: 362, E(): 1.1e-19, (42.1% identity in 140 aa overlap); etc. Also similar to other MmpS proteins from Mycobacterium tuberculosis e.g. Rv0677c, Rv0451c, etc. BELONGS TO THE MMPS FAMILY.	X2BEY5,P0A5K1,P0A5K1	No				P0A5K1					X2BEY5,P0A5K1										
NC_002945.3	Mycobrowser_v4	CDS	484995	486752	.	+	0	Mb0411	fadD30		fatty-acid-amp ligase fadd30 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb0411, fadD30, len: 585 aa. Equivalent to Rv0404,len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 585 aa overlap). Probable fadD30,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa); MASC_MYCLE|P54200 masc protein from Mycobacterium leprae (372 aa), FASTA scores: opt: 888, E(): 0, (44.2% identity in 342 aa overlap). Also similar to Y06J_MYCTU|Q10976 hypothetical 67.9 kd protein (626 aa), FASTA scores: opt: 1463, E(): 0, (42.4% identity in 568 aa overlap).	X2BEY1,Q7U226,Q7U226	No				Q7U226					X2BEY1,Q7U226										
NC_002945.3	Mycobrowser_v4	CDS	486749	488131	.	+	0	Mb0412	pks6a		PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6A [FIRST PART]	Mb0412, pks6a, len: 460 aa. Equivalent to 5' end of Rv0405, len: 1402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 456 aa overlap). Probable pks6, membrane-bound polyketide synthase, highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa),FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g) splits pks6 into 2 parts, pks6a and pks6b.	Q7U225,A0A1R3XV79	No				A0A1R3XV79				IPR009081,IPR014030,IPR014031,IPR016038,IPR016039,IPR018201	Q7U225										
NC_002945.3	Mycobrowser_v4	CDS	488118	490958	.	+	0	Mb0413	pks6b		PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6B [SECOND PART]	Mb0413, pks6b, len: 946 aa. Equivalent to 3' end of Rv0405, len: 1402 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 945 aa overlap). Probable pks6, membrane-bound polyketide synthase, highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa),FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g), splits pks6 into 2 parts, pks6a and pks6b.	Q7U224,A0A1R3XV87	No				A0A1R3XV87				IPR001031,IPR001227,IPR006162,IPR009081,IPR014043,IPR016035,IPR016036,IPR016038,IPR016039,IPR020801,IPR020806	Q7U224										
NC_002945.3	Mycobrowser_v4	CDS	491802	492812	.	+	0	Mb0415	fgd1		f420-dependent glucose-6-phosphate dehydrogenase fgd1	Mb0415, fgd1, len: 336 aa. Equivalent to Rv0407,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable fgd1,F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), equivalent to others from Mycobacteria e.g. AAD38165.1|AF152394_3 from M. avium (336 aa), FASTA scores: opt: 2082, E(): 0, (89.9% identity in 336 aa overlap); AL023514|MLCB 4_7 from Mycobacterium leprae (336 aa), FASTA scores: opt: 2069, E(): 0, (89.0% identity in 336 aa overlap). Also similar to other dehydrogenases e.g. CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase from Methanofollis liminatans (330 aa). Also similar to many proteins from Mycobacterium tuberculosis e.g. Rv0953c, Rv0791c, etc. Note that previously known as fgd.	Q7U222,A0A1R3XV82	No	intermediary metabolism and respiration			A0A1R3XV82				IPR011251,IPR019944,IPR019945	Q7U222					Rv0407		Rv0407			
NC_002945.3	Mycobrowser_v4	CDS	492805	494877	.	+	0	Mb0416	pta		PROBABLE PHOSPHATE ACETYLTRANSFERASE PTA (PHOSPHOTRANSACETYLASE)	Mb0416, pta, len: 690 aa. Equivalent to Rv0408,len: 690 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 690 aa overlap). Probable pta,phosphate acetyltransferase (EC 2.3.1.8), highly similar to others e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 phosphate acetyltransferase from Escherichia coli strain K12 (713 aa), FASTA scores: opt: 1303, E(): 0, (38.0% identity in 718 aa overlap); etc. BELONGS TO THE PHOSPHATE ACETYLTRANSFERASE AND BUTYRYLTRANSFERASE FAMILY.	Q7U221,A0A1R3XV90	No	intermediary metabolism and respiration			A0A1R3XV90				IPR002505,IPR004614,IPR010766,IPR016475,IPR027417	Q7U221					Rv0408		Rv0408			
NC_002945.3	Mycobrowser_v4	CDS	494870	496027	.	+	0	Mb0417	ackA		PROBABLE ACETATE KINASE ACKA (ACETOKINASE)	Mb0417, ackA, len: 385 aa. Equivalent to Rv0409,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Probable ackA,acetate kinase (EC 2.7.2.1), highly similar to others e.g. ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis (395 aa), FASTA scores: opt: 974, E(): 0, (43.5% identity in 393 aa overlap); etc. Contains PS01075 Acetate and butyrate kinases family signature 1, PS00758 ArgE / dapE / ACY1/ CPG2 / yscS family signature 1. BELONGS TO THE ACETOKINASE FAMILY.	X2BEY2,P63410,P63410	No	intermediary metabolism and respiration			P63410					X2BEY2,P63410					Rv0409		Rv0409			
NC_002945.3	Mycobrowser_v4	CDS	502167	503189	.	+	0	Mb0423	thiO		POSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO	Mb0423, thiO, len: 340 aa. Equivalent to Rv0415,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). Possible thiO,thiamine biosynthesis oxidoreductase (EC 1.-.-.-),equivalent to T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical protein from Mycobacterium leprae (340 aa),FASTA scores: opt: 1867, E(): 0, (82.0% identity in 338 aa overlap). Shows some similarity to other thiO proteins e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see citation below); AAG31046.1|AF264948_8|THIO putative amino acid oxidase flavoprotein ThiO from Erwinia amylovora (349 aa); NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti (333 aa); etc.	Q7U217,A0A1R3XVA6	No	intermediary metabolism and respiration			A0A1R3XVA6				IPR006076,IPR012727	Q7U217					Rv0415		Rv0415			
NC_002945.3	Mycobrowser_v4	CDS	496081	498333	.	-	0	Mb0418c	pknG		SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G)	Mb0418c, pknG, len: 750 aa. Equivalent to Rv0410c,len: 750 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 750 aa overlap). pknG,serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium leprae (767 aa). Also similar to others e.g. AB76890.1|AL159139 putative serine/threonine protein kinase from Streptomyces coelicolor (774 aa); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.	X2BEZ4,P65729,P65729	No				P65729					X2BEZ4,P65729										
NC_002945.3	Mycobrowser_v4	CDS	498333	499319	.	-	0	Mb0419c	glnH		PROBABLE GLUTAMINE-BINDING LIPOPROTEIN GLNH (GLNBP)	Mb0419c, glnH, len: 328 aa. Equivalent to Rv0411c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 328 aa overlap). Probable glnH,glutamine-binding protein, membrane-bound lipoprotein (see citation below), equivalent to AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 glutamine-binding protein homolog from Mycobacterium leprae (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3% identity in 328 aa overlap). Also similar to others e.g. GLNH_BACST|P27676 glutamine-binding protein precursor from Bacillus stearothermophilus (262 aa), FASTA scores: opt: 493, E(): 7.5e-22, (37.8% identity in 193 aa overlap); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 3. Presumed attached to the membrane by a lipid anchor.	Q7U220,A0A1R3XWC9	No				A0A1R3XWC9				IPR001638	Q7U220										
NC_002945.3	Mycobrowser_v4	CDS	501369	502037	.	-	0	Mb0422c	thiE		thiamine-phosphate pyrophosphorylase thie (tmp pyrophosphorylase) (tmp-ppase) (thiamine-phosphate synthase)	Mb0422c, thiE, len: 222 aa. Equivalent to Rv0414c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable thiE,thiamin phosphate pyrophosphorylase (EC 2.5.1.3),equivalent to Q9ZBL5|AL035159|MLCB1450_17 PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE from Mycobacterium leprae (235 aa), FASTA scores: opt: 1095, E(): 0, (78.0% identity in 223 aa overlap). Also similar to others e.g. T34974|5689976|CAB52013.1|AL109663 probable thiamin phosphate pyrophosphorylase from Streptomyces coelicolor (223 aa); THIE_ECOLI|P30137 thie protein from Escherichia coli strain K12 (211 aa), FASTA scores: opt: 275, E(): 7.8e-12, (37.8% identity in 196 aa overlap); etc. BELONGS TO THE TMP-PPASE FAMILY.	X2BEY7,P66917,P66917	No				P66917					X2BEY7,P66917										
NC_002945.3	Mycobrowser_v4	CDS	503385	504143	.	+	0	Mb0425	thiG		PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG (THIAZOLE BIOSYNTHESIS PROTEIN)	Mb0425, thiG, len: 252 aa. Equivalent to Rv0417,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 252 aa overlap). Probable thiG, thiamin biosynthesis protein, equivalent to AL035159|MLCB1450_20|T44741|THIG probable thiamin biosynthesis protein from Mycobacterium leprae (261 aa),FASTA scores: opt: 1380, E(): 0, (86.8% identity in 250 aa overlap). Also highly similar to others e.g. SCOEDB|SC6E10.03|T35490|THIG probable thiazole biosynthesis protein from Streptomyces coelicolor (264 aa); F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG thiamin biosynthesis protein thiG from Xylella fastidiosa (275 aa); P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089.1|U00006 THIG PROTEIN thiamin biosynthesis protein from Escherichia coli strain K-12 (281 aa); etc. BELONGS TO THE THIG FAMILY.	X2BF00,P59948,P59948	No	intermediary metabolism and respiration			P59948					X2BF00,P59948					Rv0417		Rv0417			
NC_002945.3	Mycobrowser_v4	CDS	504515	506017	.	+	0	Mb0426	lpqL		PROBABLE LIPOPROTEIN AMINOPEPTIDASE LPQL	Mb0426, lpqL, len: 500 aa. Equivalent to Rv0418,len: 500 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 500 aa overlap). Probable lpqL,lipoprotein aminopeptidase (EC 3.4.11.-), similar to others e.g. B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 probable aminopeptidase from Pseudomonas aeruginosa (536 aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase (EC 3.4.11.-) from Streptomyces griseus (284 aa) (homology only with C-terminus of Rv0418); P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y (EC 3.4.11.-) from Saccharomyces cerevisiae (537 aa); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U215,A0A1R3XV97	No	cell wall and cell processes			A0A1R3XV97				IPR003137,IPR007484	Q7U215					Rv0418		Rv0418			
NC_002945.3	Mycobrowser_v4	CDS	506105	507601	.	+	0	Mb0427	lpqM		POSSIBLE LIPOPROTEIN PEPTIDASE LPQM	Mb0427, lpqM, len: 498 aa. Equivalent to Rv0419,len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 498 aa overlap). Possible lpqM,lipoprotein peptidase (EC 3.4.-.-); has potential N-terminal signal peptide and contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.	Q7U214,A0A1R3XVA7	No	cell wall and cell processes			A0A1R3XVA7					Q7U214					Rv0419		Rv0419			
NC_002945.3	Mycobrowser_v4	CDS	517036	517911	.	-	0	Mb0435c	xthA		PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI)	Mb0435c, xthA, len: 291 aa. Equivalent to Rv0427c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (EC 3.1.11.2), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. BELONGS TO THE AP/EXOA FAMILY OF DNA REPAIR ENZYMES.	Q7U208,A0A1R3XVA3	No				A0A1R3XVA3				IPR004808,IPR005135	Q7U208										
NC_002945.3	Mycobrowser_v4	CDS	508777	509574	.	-	0	Mb0430c	thiD		PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE)	Mb0430c, thiD, len: 265 aa. Equivalent to Rv0422c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Probable thiD,phosphomethylpyrimidine kinase (EC 2.7.4.7), equivalent to AL035159|MLCB1450_21 PHOSPHOMETHYLPYRIMIDINE KINASE from Mycobacterium leprae (279 aa), FASTA scores: opt: 1386,E(): 0, (77.8% identity in 266 aa overlap). Also highly similar to others e.g. HIU32725_3|P44697|THID_HAEIN PHOSPHOMETHYLPYRIMIDINE KINASE from Haemophilus influenzae (269 aa), FASTA scores: opt: 605, E(): 0, (42.1% identity in 259 aa overlap). BELONGS TO THE THID FAMILY.	X2BF06,P66914,P66914	No				P66914					X2BF06,P66914										
NC_002945.3	Mycobrowser_v4	CDS	509601	511244	.	-	0	Mb0431c	thiC		PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC	Mb0431c, thiC, len: 547 aa. Equivalent to Rv0423c,len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 547 aa overlap). Probable thiC,thiamin biosynthesis protein, equivalent to Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity in 547 aa overlap). Also highly similar to others e.g. P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E(): 0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI THIC PROTEIN from Escherichia coli strain K12 (631 aa),FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa overlap); etc. BELONGS TO THE THIC FAMILY.	X2BF01,P66912,P66912	No				P66912					X2BF01,P66912										
NC_002945.3	Mycobrowser_v4	CDS	511721	516340	.	-	0	Mb0433c	ctpH		POSSIBLE METAL CATION TRANSPORTING P-TYPE ATPASE CTPH	Mb0433c, ctpH, len: 1539 aa. Equivalent to Rv0425c,len: 1539 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1539 aa overlap). Possible ctpH,metal cation-transporting P-type ATPase (transmembrane protein) (EC 3.6.1.-), showing some similarity with CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative cation-transporting ATPase from Mycobacterium leprae (1609 aa). Also similar to others ATPases e.g. AE000873_1 CATION-TRANSPORTING P-ATPASE from Methanobacterium thermoautotrop (844 aa), FASTA score: (30.5% identity in 827 aa overlap); AB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); etc. C-terminal region similar to other ATPases from Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative cation-transporting ATPase C (855 aa), FASTA scores: opt: 770, E(): 5.3e-32, (44.9% identity in 820 aa overlap).	Q7U210,A0A1R3XVB8	No				A0A1R3XVB8				IPR001757,IPR006068,IPR008250,IPR023214,IPR023298,IPR023299	Q7U210										
NC_002945.3	Mycobrowser_v4	CDS	518822	519415	.	-	0	Mb0437c	def		PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	Mb0437c, def, len: 197 aa. Equivalent to Rv0429c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 197 aa overlap). Probable def,polypeptide deformylase (EC 3.5.1.31), equivalent to CAC30884.1|AL583923 polypeptide deformylase from Mycobacterium leprae (197 aa). Also similar to others e.g. DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from Escherichia coli (169 aa), FASTA scores: opt: 179, E(): 1.8e-05, (34.6% identity in 162 aa overlap); etc. BELONGS TO THE POLYPEPTIDE DEFORMYLASE FAMILY. COFACTOR: BINDS 1 ZINC ION.	X2BF02,Q7U206,Q7U206	No				Q7U206					X2BF02,Q7U206										
NC_002945.3	Mycobrowser_v4	CDS	520619	521341	.	+	0	Mb0440	sodC		periplasmic superoxide dismutase [cu-zn] sodc	Mb0440, sodC, len: 240 aa. Equivalent to Rv0432,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable sodC,periplasmic superoxide dismutase [Cu-Zn] (EC 1.15.1.1),equivalent to CAC30880.1|AL583923 superoxide dismutase precursor (Cu-Zn) from Mycobacterium leprae (240 aa); and AAK20038.1|AF326234_1 copper zinc superoxide dismutase from Mycobacterium avium subsp. paratuberculosis (226 aa). Also similar to others e.g. SODC_PHOLE|P00446 superoxide dismutase precursor (cu-zn) from Photobacterium leiognathi (173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5% identity in 181 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. BELONGS TO THE CU-ZN SUPEROXIDE DISMUTASE FAMILY. Possibly localized in periplasm, membrane-bound.	X2BF16,P0A609,P0A609	No	virulence, detoxification, adaptation			P0A609					X2BF16,P0A609					Rv0432		Rv0432			
NC_002945.3	Mycobrowser_v4	CDS	525549	526409	.	-	0	Mb0444c	pssA		PROBABLE CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE PSSA (PS SYNTHASE) (PHOSPHATIDYLSERINE SYNTHASE)	Mb0444c, pssA, len: 286 aa. Equivalent to Rv0436c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Probable pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (EC 2.7.8.8) (see citation below), integral membrane protein, equivalent to AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in 285 aa overlap). Also highly similar to others e.g. NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine synthase from Mesorhizobium loti (248 aa); PSS_BACSU|P39823 cdp-diacylglycerol--serine o-phosphatidyltransferase from Bacillus subtilis (177 aa),FASTA scores: opt: 277, E(): 9.9e-12, (33.3% identity in 183 aa overlap); etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY.	X2BEX8,P59949,P59949	No				P59949					X2BEX8,P59949										
NC_002945.3	Mycobrowser_v4	CDS	526406	527101	.	-	0	Mb0445c	psd		POSSIBLE PHOSPHATIDYLSERINE DECARBOXYLASE PSD (PS DECARBOXYLASE)	Mb0445c, psd, len: 231 aa. Equivalent to Rv0437c,len: 231 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 231 aa overlap). Possible psd, phosphatidylserine decarboxylase (EC 4.1.1.65), equivalent to CAC29819.1|AL583918 conserved hypothetical protein from Mycobacterium leprae (243 aa); and highly similar to MLCB1450.11|T44729|4154044|CAA22695.1|AL035159 hypothetical protein from Mycobacterium leprae (202 aa),FASTA score: (74.6% identity in 197 aa overlap). Also similar to other phosphatidylserine decarboxylases e.g. NP_108058.1|14027249|BAB54203.1|AP003012 phosphatidylserine decarboxylase from Mesorhizobium loti (232 aa); AAK86872|g15156090|AGR_C_1963 phosphatidylserine decarboxylase from Agrobacterium tumefaciens (244 aa); AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase from Chlorobium tepidum (216 aa); etc.	X2BF21,P67548,P67548	No				P67548					X2BF21,P67548										
NC_002945.3	Mycobrowser_v4	CDS	534110	534808	.	-	0	Mb0452c	rska		anti-sigma factor rska (regulator of sigma k)	Mb0452c, -, len: 232 aa. Equivalent to Rv0444c,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 232 aa overlap). Conserved hypothetical protein; C-terminus similar to P12752|Y24K_STRGR HYPOTHETICAL 24.7 KD PROTEIN from Streptomyces griseus (238 aa), FASTA scores: opt: 207, E(): 2.2e-05, (32.9% identity in 158 aa overlap).	X2BF17,Q7U1Z7,Q7U1Z7	No	information pathways			Q7U1Z7					X2BF17,Q7U1Z7					Rv0444c		Rv0444c			
NC_002945.3	Mycobrowser_v4	CDS	527162	528379	.	-	0	Mb0446c	moeA2		PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA2	Mb0446c, moeA2, len: 405 aa. Equivalent to Rv0438c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 405 aa overlap). Probable moeA2,molybdenum cofactor biosynthesis protein, highly similar to many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 aa), FASTA scores: opt: 786, E(): 0, (39.2% identity in 398 aa overlap); etc. Also similar to MOEA1|Rv0994|MTCI237.08|O05577 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (426 aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity in 425 aa overlap). Note that previously known as moeA3.	Q7U201,A0A1R3XVB3	No				A0A1R3XVB3				IPR001453,IPR005110,IPR005111,IPR020817	Q7U201										
NC_002945.3	Mycobrowser_v4	CDS	529627	531249	.	+	0	Mb0448	groEL2		60 KDA CHAPERONIN 2 GROEL2 (PROTEIN CPN60-2) (GROEL PROTEIN 2) (65 KDA ANTIGEN) (HEAT SHOCK PROTEIN 65) (CELL WALL PROTEIN A) (ANTIGEN A)	Mb0448, groEL2, len: 540 aa. Equivalent to Rv0440,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). groEL2 (alternate gene names: groL2, groEL-2, hsp65, hsp60), 60 kDa chaperonin 2 (see first citation below). PURIFIED 65 kDa ANTIGEN CAN ELICIT A STRONG DELAYED-TYPE HYPERSENSITIVITY REACTION IN EXPERIMENTAL ANIMALS INFECTED WITH M. TUBERCULOSIS. THIS PROTEIN IS ONE OF THE MAJOR IMMUNOREACTIVE PROTEINS OF THE MYCOBACTERIA. THIS ANTIGEN CONTAINS EPITOPES THAT ARE COMMON TO VARIOUS SPECIES OF MYCOBACTERIA. Contains PS00296 Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY.	X2BF25,P0A521,P0A521	No				P0A521					X2BF25,P0A521										
NC_002945.3	Mycobrowser_v4	CDS	531770	533209	.	-	0	Mb0450c	PPE10		ppe family protein ppe10	Mb0450c, PPE10, len: 479 aa. Equivalent to Rv0442c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 479 aa overlap). Member of the Mycobacterium tuberculosis PPE family, nearly identical to hypothetical protein from Mycobacterium tuberculosis (strain Erdman) and to AN5S46909_1 protein fragment from Mycobacterium bovis (302 aa); P42611|YHS6_MYCTU HYPOTHETICAL 50.6 KD PROTEIN (517 aa), FASTA scores: opt: 3144, E(): 0, (98.4 identity in 492 aa overlap); and S46909|S46909_1 (302 aa), FASTA scores: opt: 1897, E(): 0,(98.0% identity in 302 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 5' start due to a single base transition (g-a), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa).	Q7U1Z9,A0A1R3XVH9	No				A0A1R3XVH9				IPR000030,IPR002989	Q7U1Z9										
NC_002945.3	Mycobrowser_v4	CDS	534852	535415	.	-	0	Mb0453c	sigK		alternative rna polymerase sigma factor sigk	Mb0453c, sigK, len: 187 aa. Equivalent to Rv0445c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable sigK,alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. 5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase sigma factor from Streptomyces coelicolor (185 aa); NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase sigma factor from Mesorhizobium loti (179 aa); 1654108|AAB17906.1|U11283|A58883 probable transcription initiation factor sigma E from Rhodobacter phaeroides (168 aa), FASTA scores: opt: 299, E(): 2e-14, (32.7% identity in 168 aa overlap); Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FACTOR SIGW from Bacillus subtilis (187 aa), FASTA scores: opt: 213, E(): 2.9e-08, (26.8% identity in 179 aa overlap); etc.	X2BF30,Q7U1Z6,Q7U1Z6	No				Q7U1Z6					X2BF30,Q7U1Z6										
NC_002945.3	Mycobrowser_v4	CDS	536243	537526	.	-	0	Mb0455c	ufaA1		probable cyclopropane-fatty-acyl-phospholipid synthase ufaa1 (cyclopropane fatty acid synthase) (cfa synthase)	Mb0455c, ufaA1, len: 427 aa. Equivalent to Rv0447c,len: 427 aa (start uncertain), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 427 aa overlap). Probable ufaA1,cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79), similar to others e.g. NP_102178.1|14021351|BAB47964.1|AP002994 cyclopropane-fatty-acyl-phospholipid synthase from Mesorhizobium loti (378 aa); B82240|9655593|AAF94281.1|AE004192 cyclopropane-fatty-acyl-phospholipid synthase from Vibrio cholerae (432 aa); P30010|CFA_ECOLI CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3 LPD-3 from P.putida (394 aa), FASTA scores: opt: 556, E(): 2.8e-30, (33.3% identity in 387 aa overlap); AE0005|HPAE000557_9 from Helicobacter pylori (389 aa),FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity in 382 aa overlap).	Q7U1Z4,A0A1R3XVC3	No				A0A1R3XVC3				IPR003333	Q7U1Z4										
NC_002945.3	Mycobrowser_v4	CDS	539607	542510	.	-	0	Mb0458c	mmpL4		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL4	Mb0458c, mmpL4, len: 967 aa. Equivalent to Rv0450c,len: 967 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 967 aa overlap). Probable mmpL4,conserved transmembrane transport protein (see citations below), member of RND superfamily, equivalent to U1740V|P54881|YV34_MYCLE HYPOTHETICAL 105.2 kDa PROTEIN from Mycobacterium leprae (959 aa), FASTA scores: opt: 5051, E(): 0, (78.4% identity in 962 aa overlap). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores: opt: 3917, E(): 0, (61.3% identity in 950 aa overlap),MTCY20G9.34, etc. Contains PS00211 ABC transporters family signature. BELONGS TO THE MMPL FAMILY. TBparse score is 0.948.	Q7U1Z1,A0A1R3XXJ1	No				A0A1R3XXJ1				IPR004707,IPR004869	Q7U1Z1										
NC_002945.3	Mycobrowser_v4	CDS	542507	542929	.	-	0	Mb0459c	mmpS4		PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4	Mb0459c, mmpS4, len: 140 aa. Equivalent to Rv0451c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable mmpS4,conserved membrane protein (see citations below),equivalent to U1740W|P54880|YV33_MYCLE HYPOTHETICAL 16.9 kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 727, E(): 0, (75.9% identity in 137 aa overlap). Also similar to other Mycobacterial proteins e.g. Z84725|MTCY04D9.16c from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0% identity in 138 aa overlap); etc. BELONGS TO THE MMPS FAMILY. TBparse score is 0.953.	X2BEZ3,P0A5K3,P0A5K3	No				P0A5K3					X2BEZ3,P0A5K3										
NC_002945.3	Mycobrowser_v4	CDS	544193	545749	.	+	0	Mb0461	PPE11		ppe family protein ppe11	Mb0461, PPE11, len: 518 aa. Equivalent to Rv0453,len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 518 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 882, E(): 7e-31, (41.8% identity in 514 aa overlap).	Q7U1Y9,A0A1R3XVY0	No				A0A1R3XVY0				IPR000030	Q7U1Y9										
NC_002945.3	Mycobrowser_v4	CDS	546908	547822	.	-	0	Mb0464c	echA2		ENOYL-COA HYDRATASE ECHA2 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb0464c, echA2, len: 304 aa. Equivalent to Rv0456c,len 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Probable echA2,enoyl-CoA hydratase (EC 4.2.1.17), similar to other enoyl-coA hydratases e.g. Q13011 PEROXISOMAL ENOYL-COA HYDRATASE-LIKE PROTEIN (328 aa), FASTA scores: opt: 209,E(): 5.3e-07, (31.7% identity in 142 aa overlap). Also similar to several other proteins from Mycobacterium tuberculosis e.g. MTCY09F9.29 FASTA score: (32.9% identity in 146 aa overlap); and MTI376.01c.	Q7U1Y6,A0A1R3XVF0	No				A0A1R3XVF0				IPR001753,IPR018376	Q7U1Y6										
NC_002945.3	Mycobrowser_v4	CDS	641576	641884	.	-	0	Mb0564c	vapc3		CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]	Mb0564c, -, len: 102 aa. Similar to 5' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 92 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065,and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c.	Q7U1S9,A0A1R3XVP5	No				A0A1R3XVP5					Q7U1S9										
NC_002945.3	Mycobrowser_v4	CDS	553633	555027	.	+	0	Mb0471	lpd		dihydrolipoamide dehydrogenase lpdc (lipoamide reductase (nadh)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase)	Mb0471, lpd, len: 464 aa. Equivalent to Rv0462,len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 464 aa overlap). lpd (alternate gene name: TB49.2), dihydrolipoamide dehydrogenase (EC 1.8.1.4) (see first citation below), equivalent to AAA63016.1|U15183 lipoamide dehydrogenase from Mycobacterium leprae (467 aa), FASTA scores: opt: 2583,E(): 0, (83.1% identity in 467 aa overlap). Also similar to to many e.g. P50970|DLDH_ZYMMO|X82291|ZMLPD_1 DIHYDROLIPOAMIDE DEHYDROGENASE from Z.mobilis (466 aa),FASTA scores: opt: 1198, E(): 0, (42.4 % identity in 465 aa overlap); etc. BELONG TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I.	X2BF35,P66005,P66005	No	intermediary metabolism and respiration			P66005					X2BF35,P66005					Rv0462		Rv0462			
NC_002945.3	Mycobrowser_v4	CDS	558546	559832	.	+	0	Mb0476	icl		ISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE)	Mb0476, icl, len: 428 aa. Equivalent to Rv0467,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). icl (previously known as aceA), isocitrate lyase (EC 4.1.3.1) (see citations below), highly similar to many, closest to Z29367|RFISCILY_1 from R. fascians (429 aa), FASTA scores: opt: 2359, E(): 0, (80.7% identity in 429 aa overlap). BELONGS TO THE ISOCITRATE LYASE FAMILY.	X2BF40,P0A5H4,P0A5H4	No	intermediary metabolism and respiration			P0A5H4					X2BF40,P0A5H4					Rv0467		Rv0467			
NC_002945.3	Mycobrowser_v4	CDS	559914	560774	.	+	0	Mb0477	fadB2		3-hydroxybutyryl-coa dehydrogenase fadb2 (beta-hydroxybutyryl-coa dehydrogenase) (bhbd)	Mb0477, fadB2, len: 286 aa. Equivalent to Rv0468,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Probable fadB2,3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157),equivalent to CAC31978.1|AL583925 3-hydroxyacyl-CoA dehydrogenase from Mycobacterium leprae (287 aa). Also similar to many 3-hydroxybutyryl-CoA dehydrogenases e.g. U32229|BJU32229_1 beta-hydroxybutyryl coenzyme A dehydrogenase from Bradyrhizobium japonicum (293 aa),FASTA scores: opt: 771, E(): 0, (45.7% identity in 282 aa overlap). BELONGS TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY.	Q7U1X6,A0A1R3XXL1	No				A0A1R3XXL1				IPR006108,IPR006176,IPR008927,IPR013328,IPR016040,IPR022694	Q7U1X6										
NC_002945.3	Mycobrowser_v4	CDS	560907	561767	.	+	0	Mb0478	umaA1		possible mycolic acid synthase umaa	Mb0478, umaA1, len: 286 aa. Equivalent to Rv0469,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible umaA1,mycolic acid synthase (EC 2.-.-.-), highly similar to CAC30854.1|AL583923 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa),FASTA scores: opt: 1402, E(): 0, (69.6% identity in 286 aa overlap). Also very similar to mycobacterial methyltransferases e.g. U77466|CmaD|MBU77466_1 (286 aa); MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar to CFA1_MYCTU|Q11195|U66108|MTU66108_1 cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa),FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa overlap) (see citation below); and very similar also to methoxy mycolic acid synthase 1 from Mycobacterium tuberculosis e.g. MTU66108_1 (286 aa).	Q7U1X5,A0A1R3XWH3	No				A0A1R3XWH3				IPR003333	Q7U1X5										
NC_002945.3	Mycobrowser_v4	CDS	561867	562730	.	-	0	Mb0479c	pcaA		MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE)	Mb0479c, pcaA, len: 287 aa. Equivalent to Rv0470c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). pcaA (previously known as umaA2), mycolic acid synthase (cyclopropane synthase) (EC 2.-.-.-) (see citations below), equivalent to CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa); and highly similar to S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical protein from Mycobacterium leprae (308 aa); Q11195|CFA1_MYCTU CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) (287 aa) (see second citation below); U27357|MTU27357_1 cyclopropane mycolic acid synthase from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 1415, E(): 0,(72.8% identity in 287 aa overlap); and related enzymes e.g. MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA scores: opt: 1387, E(): 0, (72.5% identity in 287 aa overlap).	Q7U1X4,A0A1R3XVK4	No				A0A1R3XVK4				IPR003333	Q7U1X4										
NC_002945.3	Mycobrowser_v4	CDS	566816	567415	.	+	0	Mb0485	hbhA		iron-regulated heparin binding hemagglutinin hbha (adhesin)	Mb0485, hbhA, len: 199 aa. Equivalent to Rv0475,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). hbhA, heparin-binding hemagglutinin (see citations below), equivalent to CAC31971.1|AL583925 possible hemagglutinin from Mycobacterium leprae (188 aa). Contains possible N-terminal signal sequence and K-A-rich region at C-terminus: SUBCELLULAR LOCATION: SURFACE ASSOCIATED.	X2BF49,P0C2T3,P0C2T3	No	cell wall and cell processes			P0C2T3					X2BF49,P0C2T3					Rv0475		Rv0475			
NC_002945.3	Mycobrowser_v4	CDS	568241	568915	.	+	0	Mb0488	deoC		PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE)	Mb0488, deoC, len: 224 aa. Equivalent to Rv0478,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable deoC,deoxyribose-phosphate aldolase (EC 4.1.2.4), equivalent to Q9CB45|DEOC_MYCLE DEOXYRIBOSE-PHOSPHATE ALDOLASE from M. leprae (226 aa). Also highly similar to others e.g. DEOC_BACSU|P39121 from Bacillus subtilis (214 aa), FASTA scores: opt: 543, E(): 1.4e-26, (45.9% identity in 209 aa overlap); etc. BELONGS TO THE DEOC/FBAB FAMILY OF ALDOLASES, DEOC SUBFAMILY.	X2BF23,P63930,P63930	No	intermediary metabolism and respiration			P63930					X2BF23,P63930					Rv0478		Rv0478			
NC_002945.3	Mycobrowser_v4	CDS	595022	595930	.	-	0	Mb0515c	cmaA2		CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID TRANS-CYCLOPROPANE SYNTHETASE)	Mb0515c, cmaA2, len: 302 aa. Equivalent to Rv0503c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). cmaA2 (alternate gene name: cma2), cyclopropane-fatty-acyl-phospholipid synthase 2 (mycolic acid trans-cyclopropane synthetase) (EC 2.1.1.79) (see citations below). Note that this protein has 302 aa and not 322 aa: we have chosen a different initiation codon on the basis of homology). Equivalent to S72886|B2168_F3_130 hypothetical protein from Mycobacterium leprae (308 aa), FASTA score: (78.9% identity in 303 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also similar to other proteins from Mycobacterium tuberculosis and Mycobacterium bovis BCG e.g. MTV038_14|UMAA2|Rv0470c|MTV038.14 PUTATIVE MYCOLIC ACID SYNTHESIS/MODIFICATION PROTEIN (287 aa) (57.2% identity in 297 aa overlap).	X2BFA2,P0A5P1,P0A5P1	No				P0A5P1					X2BFA2,P0A5P1										
NC_002945.3	Mycobrowser_v4	CDS	571502	572611	.	+	0	Mb0492	murB		PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE)	Mb0492, murB, len: 369 aa. Equivalent to Rv0482,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 369 aa overlap). Probable murB,UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158), equivalent to CAC31964.1|AL583925 UDP-N-acetylenolpyruvoylglucosamine reductase from Mycobacterium leprae (367 aa). Also highly similar to others e.g. MURB_ECOLI|P08373 UDP-N-acetylenolpyruvoylglucosamine reductase from Escherichia coli (342 aa), FASTA scores: opt: 292, E(): 6.3e-12, (33.5% identity in 355 aa overlap); etc. BELONGS TO THE MURB FAMILY. COFACTOR: FAD.	X2BF62,P65461,P65461	No	cell wall and cell processes			P65461					X2BF62,P65461					Rv0482		Rv0482			
NC_002945.3	Mycobrowser_v4	CDS	572673	574028	.	+	0	Mb0493	lprQ		PROBABLE CONSERVED LIPOPROTEIN LPRQ	Mb0493, lprQ, len: 451 aa. Equivalent to Rv0483,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). Probable lprQ,conserved lipoprotein, equivalent to CAC31963.1|AL583925|ML2446 possible lipoprotein from Mycobacterium leprae (441 aa); appears longer than ML2446,so start may be further downstream. Shows also similarity with MLCL383_24|O07707 HYPOTHETICAL 43.6 KD PROTEIN from Mycobacterium leprae; and to Q49706|B1496_F2_81 (271 aa). Similar to others lipoproteins from other organisms. Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0116c, Rv0192, Rv1433, Rv2518c. Contains potential N-terminal signal sequence and appropriately positioned PS00013 prokaryotic membrane lipoprotein lipid attachment site.	X2BF28,P64704,P64704	No	cell wall and cell processes			P64704					X2BF28,P64704					Rv0483		Rv0483			
NC_002945.3	Mycobrowser_v4	CDS	576311	577753	.	+	0	Mb0496	msha		glycosyltransferase msha	Mb0496, -, len: 480 aa. Equivalent to Rv0486, len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Mannosyltransferase (EC 2.4.1.-) (see citations below), highly similar to P54138|Y486_MYCLE|ML2443 possible glycosyl transferase from Mycobacterium leprae (428 aa); and S72892|B2168_C2_201 probable hexosyltransferase (EC 2.4.1.-) from Mycobacterium leprae (409 aa), FASTA scores: opt: 2375, E(): 0, (86.4% identity in 413 aa overlap). Also highly similar to CAC04040.1|AL391406 putative transferase from Streptomyces coelicolor (496 aa); and similar to various transferases e.g. NP_437172.1|NC_003078 putative membrane-anchored glycosyltransferase protein from Sinorhizobium meliloti (416 aa); O26550|U67601_1 LPS BIOSYNTHESIS RELATED PROTEIN from Methanococcus jannaschii (411 aa), FASTA score: (25.3% identity in 387 aa overlap); etc. Also similar to CAC87824.1|AJ316594 putative sucrose-phosphate synthase from Nostoc punctiforme (422 aa). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature.	X2BF79,P64708,P64708	No	intermediary metabolism and respiration			P64708					X2BF79,P64708					Rv0486		Rv0486			
NC_002945.3	Mycobrowser_v4	CDS	579447	580196	.	+	0	Mb0499	gpm1		PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	Mb0499, gpm1, len: 249 aa. Equivalent to Rv0489,len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 249 aa overlap). Probable gpm1,phosphoglycerate mutase 1 (EC 5.4.2.1), equivalent to P53531|PMGY_MYCLE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (247 aa). Also highly similar to others e.g. PMG1_ECOLI|P31217 (249 aa), FASTA scores: opt: 805, E(): 0, (51.4% identity in 245 aa overlap); etc. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOSPHOGLYCERATE MUTASE FAMILY. Note that previously known as gpm.	X2BF75,P0A5R7,P0A5R7	No	intermediary metabolism and respiration			P0A5R7					X2BF75,P0A5R7					Rv0489		Rv0489			
NC_002945.3	Mycobrowser_v4	CDS	580370	581602	.	+	0	Mb0500	senX3		PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	Mb0500, senX3, len: 410 aa. Equivalent to Rv0490,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 410 aa overlap). Putative senX3,two-component sensor histidine kinase (EC 2.7.3.-),transmembrane protein (see citations below), equivalent to O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0,(99.5% identity in 410 aa overlap); and highly similar to P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from Mycobacterium leprae (443 aa), FASTA score: (83.8% identity in 408 aa overlap). Also highly similar, except in N-terminus, to CAC31957.1|AL583925 probable two-component system sensor histidine kinase from Mycobacterium leprae (441 aa). Also highly similar to sensor kinase proteins from other organisms e.g. CAB77323.1|AL160331 putative sensor kinase protein from Streptomyces coelicolor (426 aa).	X2BF71,P0A601,P0A601	No				P0A601					X2BF71,P0A601										
NC_002945.3	Mycobrowser_v4	CDS	581960	582643	.	+	0	Mb0501	regX3		TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY)	Mb0501, regX3, len: 227 aa. Equivalent to Rv0491,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). regX3, response regulator protein (sensory transduction protein) (see citations below), equivalent to O07130|RGX3_MYCBO|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium bovis BCG (227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response regulator from Mycobacterium smegmatis (228 aa); equivalent to P54884|RGX3_MYCLE|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium leprae (198 aa), FASTA scores : E(): 0, (95.4% identity in 197 aa overlap). Also highly similar to other response regulators e.g. AAG43239.1|AF123314_2 |AF123314 putative response regulator from Corynebacterium glutamicum (232 aa).	X2BF91,O07130,O07130	No				O07130					X2BF91,O07130										
NC_002945.3	Mycobrowser_v4	CDS	1453212	1453454	.	+	0	Mb1330	rpmE		50s ribosomal protein l31 rpme	Mb1330, rpmE, len: 80 aa. Equivalent to Rv1298,len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 80 aa overlap). Probable rpmE, 50s ribosomal protein L31, highly similar to many e.g. RL31_MYCLE|P45834 50s ribosomal protein L31 from Mycobacterium leprae (84 aa), FASTA scores: opt: 490, E(): 5.5e-28, (89.6% identity in 77 aa overlap). Contains PS01143 Ribosomal protein L31 signature. BELONGS TO THE L31P FAMILY OF RIBOSOMAL PROTEINS.	X2BHB4,P66188,P66188	No	information pathways			P66188					X2BHB4,P66188					Rv1298		Rv1298			
NC_002945.3	Mycobrowser_v4	CDS	621041	622015	.	+	0	Mb0542	ccsA		POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCSA	Mb0542, ccsA, len: 324 aa. Equivalent to Rv0529,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Possible ccsA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to NP_302558.1|NC_002677|B2168_C3_281 possible cytochrome C biogenesis protein from Mycobacterium leprae (327 aa), FASTA scores: opt: 1779,E(): 0, (82.9% identity in 327 aa overlap). Also highly similar to others e.g. CAC08382.1|AL392176 putative cytochrome biogenesis related protein from Streptomyces coelicolor (380 aa); CCSA_CHLRE|P48269 probable cytochrome c biogenesis protein from Chlamydomonas reinhardtii (353 aa), FASTA scores: opt: 449, E(): 1.3e-23, (34.4% identity in 247 aa overlap); etc. BELONGS TO THE CCMF/CYCK/CCL1/NRFE/CCSA FAMILY. Note that previously known as ccsB.	Q7U1U5,A0A1R3XVP8	No	intermediary metabolism and respiration			A0A1R3XVP8				IPR002541,IPR017562	Q7U1U5					Rv0529		Rv0529			
NC_002945.3	Mycobrowser_v4	CDS	591234	592121	.	+	0	Mb0511	proC		PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C REDUCTASE)	Mb0511, proC, len: 295 aa. Equivalent to Rv0500,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 295 aa overlap). Probable proC,Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (see citation below), equivalent to P46725|PROC_MYCLE PYRROLINE-5-CARBOXYLATE REDUCTASE from Mycobacterium leprae (294 aa), FASTA scores: opt: 1473, E(): 0, (82.4% identity in 295 aa overlap). Also similar to others e.g. P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTASE from Corynebacterium glutamicum (270 aa); T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate reductase from Streptomyces coelicolor (284 aa); etc. BELONGS TO THE PYRROLINE-5-CARBOXYLATE REDUCTASE FAMILY.	Q7U1W3,A0A1R3XVG8	No	intermediary metabolism and respiration			A0A1R3XVG8				IPR000304,IPR008927,IPR016040,IPR028939	Q7U1W3					Rv0500		Rv0500			
NC_002945.3	Mycobrowser_v4	CDS	641881	642147	.	-	0	Mb0565c	vapb3		possible antitoxin vapb3	Mb0565c, -, len: 88 aa. Equivalent to Rv0550c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Hypothetical unknown protein.	Q7U1S8,A0A1R3XVP2	No	virulence, detoxification, adaptation			A0A1R3XVP2				IPR009956	Q7U1S8					Rv0550c		Rv0550c			
NC_002945.3	Mycobrowser_v4	CDS	592805	593935	.	+	0	Mb0513	galE2		POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE)	Mb0513, galE2, len: 376 aa. Equivalent to Rv0501,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible galE2,UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar (except in N-terminus) to CAC31944.1|AL583925 possible glucose epimerase/dehydratase from Mycobacterium leprae (364 aa). N-terminus highly similar to S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical protein from Mycobacterium leprae (180 aa), FASTA scores: opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and C-terminus highly similar to S72898|467050|AAA17234.1|U00018 hypothetical protein from Mycobacterium leprae (168 aa), FASTA scores: opt: 928,E(): 0, (82.7% identity in 168 aa overlap). Also highly similar to T36274|5123671|CAB45360.1|AL079345 probable epimerase from Streptomyces coelicolor (353 aa); and similar in part to other epimerases e.g. GALE_ECOLI|P09147 UDP-glucose 4-epimerase from Escherichia coli (338 aa),FASTA scores: opt: 241, E(): 6.7e-09, (28.2% identity in 294 aa overlap); etc. BELONGS TO THE SUGAR EPIMERASE FAMILY. COFACTOR: NAD. Note that previously known as galE1.	X2BF87,P0A5D2,P0A5D2	No				P0A5D2					X2BF87,P0A5D2										
NC_002945.3	Mycobrowser_v4	CDS	596615	597736	.	-	0	Mb0517c	serB1		POSSIBLE PHOSPHOSERINE PHOSPHATASE SERB1 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE)	Mb0517c, serB1, len: 373 aa. Equivalent to Rv0505c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Possible serB1,phosphoserine phosphatase (EC 3.1.3.3), equivalent (but longer ~70 aa in N-terminus) to S72914|serB phosphoserine phosphatase from Mycobacterium leprae (300 aa), FASTA scores: opt: 1570, E(): 0, (83.0% identity in 306 aa overlap). C-terminus highly similar to CAB55344.1|AJ010584 phosphoserine phosphatase from Streptomyces coelicolor (266 aa). Low similarity to SERB_ECOLI|P06862 phosphoserine phosphatase from Escherichia coli strains K12 and O157:H7 (322 aa), FASTA scores: opt: 148, E(): 0.043, (24.0% identity in 150 aa overlap). C-terminus is also similar to O33611|AB004855_1|IMD_STRCN PROTEIN INVOLVED IN INHIBITION OF MORPHOLOGICAL DIFFERENTIATION from Streptomyces cyaneus (277 aa), FASTA score: (37.7% identity in 252 aa overlap). SEEMS TO BELONG TO THE SERB FAMILY. Note that previously known as serB.	X2BF63,P66802,P66802	No				P66802					X2BF63,P66802										
NC_002945.3	Mycobrowser_v4	CDS	597910	598353	.	+	0	Mb0518	mmpS2		PROBABLE CONSERVED MEMBRANE PROTEIN MMPS2	Mb0518, mmpS2, len: 147 aa. Equivalent to Rv0506,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Probable mmpS2,conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. C-terminus of AAD44232.1|AF143772_38|AF143772|TmtpA from M. avium (221 aa); P54880|MMS4_MYCLE|MMPS4 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 392, E(): 1.3e-20, (43.7% identity in 151 aa overlap); and the PUTATIVE MEMBRANE PROTEINS from Mycobacterium tuberculosis MTV040_5, MTCY4D9_16, MTV037_15. BELONGS TO THE MMPS FAMILY.	X2BF92,P65377,P65377	No				P65377					X2BF92,P65377										
NC_002945.3	Mycobrowser_v4	CDS	647541	649205	.	+	0	Mb0570	menD		PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE) (KDC)	Mb0570, menD, len: 554 aa. Equivalent to Rv0555,len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 554 aa overlap). Probable menD,menaquinone biosynthesis protein, including 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.1.3.-) and 2-oxoglutarate decarboxylase (EC 4.1.1.71) activities. Equivalent to NP_302478.1|NC_002677 putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase from Mycobacterium leprae (556 aa). Also similar to others e.g. MEND_BACSU|P23970 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase from Bacillus subtilis (548 aa), FASTA scores: opt: 488, E(): 2.3e-21, (34.3% identity in 545 aa overlap); etc. COFACTOR: THIAMINE PYROPHOSPHATE.	X2BFE4,Q7U1S4,Q7U1S4	No	intermediary metabolism and respiration			Q7U1S4					X2BFE4,Q7U1S4					Rv0555		Rv0555			
NC_002945.3	Mycobrowser_v4	CDS	598350	601256	.	+	0	Mb0519	mmpL2		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL2	Mb0519, mmpL2, len: 968 aa. Equivalent to Rv0507,len: 968 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 968 aa overlap). Probable mmpL2,conserved transmembrane transport protein (see citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCLE from Mycobacterium leprae (959 aa), FASTA scores: opt: 3699, E(): 0, (58.3% identity in 940 aa overlap); and the Mycobacterium tuberculosis proteins MTV037_14, MTV040_4, MTCY98_8,MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc. Also similar to STMACTII_3|SC10A5_9 from Streptomyces coelicolor; and BSUB0|004_12 from Bacillus subtilis. C-terminal half similar to Q50086|U1740AB from Mycobacterium leprae (386 aa), FASTA scores: opt: 1526,E(): 0, (61.5% identity in 371 aa overlap). BELONGS TO THE MMPL FAMILY.	Q7U1W1,A0A1R3XW33	No				A0A1R3XW33				IPR004707,IPR004869	Q7U1W1										
NC_002945.3	Mycobrowser_v4	CDS	601592	602998	.	+	0	Mb0521	hemA		probable glutamyl-trna reductase hema (glutr)	Mb0521, hemA, len: 468 aa. Equivalent to Rv0509,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable hemA,glutamyl-tRNA reductase (EC 1.2.1.-), equivalent to HEM1_MYCLE|P46724 GLUTAMYL-TRNA REDUCTASE from Mycobacterium leprae (467 aa), FASTA scores: opt: 2377,E(): 0, (82.3% identity in 463 aa overlap). Also highly similar (sometimes in part) to others e.g. Q9WX15|HEM1_STRCO GLUTAMYL-TRNA REDUCTASE from Streptomyces coelicolor (581 aa); P16618|HEM1_BACSU|HEMA GLUTAMYL-TRNA REDUCTASE from Bacillus subtilis (455 aa); etc. Contains PS00747 Glutamyl-tRNA reductase signature. BELONGS TO THE GLUTAMYL-TRNA REDUCTASE FAMILY.	X2BFA0,P64329,P64329	No	intermediary metabolism and respiration			P64329					X2BFA0,P64329					Rv0509		Rv0509			
NC_002945.3	Mycobrowser_v4	CDS	603008	603937	.	+	0	Mb0523	hemC		PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE)	Mb0523, hemC, len: 309 aa. Equivalent to Rv0510,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable hemC,hydroxymethylbilane synthase (porphobilinogen deaminase) (EC 4.3.1.8), equivalent to HEM3B|Q49808|HEM3_MYCLE PORPHOBILINOGEN DEAMINASE from Mycobacterium leprae (315 aa), FASTA scores: opt: 889, E(): 0, (88.1% identity in 159 aa overlap). Also highly similar to others e.g. Q9WX16|HE31_STRCO PROBABLE PORPHOBILINOGEN DEAMINASE from Streptomyces coelicolor (319 aa); Q9L6Q2|HEM3_SALTY PORPHOBILINOGEN DEAMINASE from Salmonella typhimurium (313 aa); etc. BELONGS TO THE HMBS FAMILY. COFACTOR: COVALENTLY BINDS A DIPYRROMETHANE COFACTOR TO WHICH THE PORPHOBILINOGEN SUBUNITS ARE ADDED.	X2BF64,P64337,P64337	No	intermediary metabolism and respiration			P64337					X2BF64,P64337					Rv0510		Rv0510			
NC_002945.3	Mycobrowser_v4	CDS	603970	605667	.	+	0	Mb0524	hemD		PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM)	Mb0524, hemD, len: 565 aa. Equivalent to Rv0511,len: 565 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 565 aa overlap). Probable hemD (alternate gene name: cysG), uroporphyrin-III C-methyltransferase (EC 2.1.1.107), highly similar to others e.g. CAC31936.1|AL583925 possible uroporphyrin-III C-methyltransferase from Mycobacterium leprae (563 aa); and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA scores: opt: 1946, E(): 0, (83.3% identity in 472 aa overlap); T36265|5123662|CAB45351.1|AL079345 probable uroporphyrin-III C-methyltransferase from Streptomyces coelicolor (565 aa); and similar to others e.g. AAK00606.1|AF221100_3|AF221100 from Selenomonas ruminantium subsp. ruminantium (505 aa); etc. Also similar to Rv2071c and Rv2847c from Mycobacterium tuberculosis. Note that previously known as cysG.	Q7TTP7,A0A1R3XVK1	No	intermediary metabolism and respiration			A0A1R3XVK1				IPR000878,IPR003754,IPR014776,IPR014777	Q7TTP7					Rv0511		Rv0511			
NC_002945.3	Mycobrowser_v4	CDS	605753	606742	.	+	0	Mb0525	hemB		PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH)	Mb0525, hemB, len: 329 aa. Equivalent to Rv0512,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 329 aa overlap). Probable hemB,delta-aminolevulinic acid dehydratase (EC 4.2.1.24),equivalent to 46723|HEM2_MYCLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE from Mycobacterium leprae (329 aa). Also highly similar to many e.g. P54919|HEM2_STRCO from Streptomyces coelicolor (330 aa); HEM2_ECOLI|P15002 from Escherichia coli (323 aa), FASTA scores: opt: 942, E(): 0,(47.6% identity in 317 aa overlap); etc. Contains PS00169 Delta-aminolevulinic acid dehydratase active site. BELONGS TO THE ALADH FAMILY. COFACTOR: ZINC.	Q7U1W0,A0A1R3XVJ5	No	intermediary metabolism and respiration			A0A1R3XVJ5				IPR001731,IPR013785	Q7U1W0					Rv0512		Rv0512			
NC_002945.3	Mycobrowser_v4	CDS	614188	615492	.	+	0	Mb0535	gabP		PROBABLE GABA PERMEASE GABP (4-AMINO BUTYRATE TRANSPORT CARRIER) (GAMA-AMINOBUTYRATE PERMEASE)	Mb0535, gabP, len: 434 aa. Equivalent to Rv0522,len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 434 aa overlap). Probable gabP, GABA permease (gamma-aminobutyrate permease), integral membrane protein, highly similar to others e.g. GABP_ECOLI|P25527 gaba permease from Escherichia coli (466 aa), FASTA scores: opt: 1218, E(): 0, (44.3% identity in 424 aa overlap); etc. Also similar to other Mycobacterium tuberculosis permeases e.g. MTCY13E10.06c FASTA score: (34.4% identity in 407 aa overlap). Contains PS00218 Amino acid permeases signature. Overlaps and extends Rv0523c|MTCY25D10.01 from overlapping cosmid. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY).	Q7U1V1,A0A1R3XVK8	No	cell wall and cell processes			A0A1R3XVK8				IPR002293,IPR004840,IPR004841	Q7U1V1					Rv0522		Rv0522			
NC_002945.3	Mycobrowser_v4	CDS	615985	617373	.	+	0	Mb0537	hemL		PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	Mb0537, hemL, len: 462 aa. Equivalent to Rv0524,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Probable hemL,glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8),equivalent to P46716|GSA_MYCLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE from Mycobacterium leprae (446 aa), FASTA scores: opt: 1532, E(): 0, (82.6% identity in 460 aa overlap). Also highly similar to others e.g. Q9F2S0|GSA_STRCO from Streptomyces coelicolor (438 aa); Q06774|GSA_PROFR from Propionibacterium freudenreichii (441 aa); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE.	X2BFC4,P63507,P63507	No	intermediary metabolism and respiration			P63507					X2BFC4,P63507					Rv0524		Rv0524			
NC_002945.3	Mycobrowser_v4	CDS	618643	619422	.	+	0	Mb0540	ccdA		POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCDA	Mb0540, ccdA, len: 259 aa. Equivalent to Rv0527,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 259 aa overlap). Possible ccdA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to Q49810|B2168_C1_192|S72890 hypothetical protein from Mycobacterium leprae (262 aa),FASTA scores: opt: 1341, E(): 0, (79.0% identity in 262 aa overlap). Also highly similar to others e.g. CAC08380.1 (253 aa); CCDA_BACSU|P45706 cytochrome C-type biogenesis protein from Bacillus subtilis (235 aa), FASTA scores: opt: 307, E(): 7.4e-13, (30.4% identity in 237 aa overlap); etc. SEEMS TO BELONG TO THE DSBD SUBFAMILY. Note that previously known as ccsA.	Q7U1U7,A0A1R3XW53	No	intermediary metabolism and respiration			A0A1R3XW53				IPR003834	Q7U1U7					Rv0527		Rv0527			
NC_002945.3	Mycobrowser_v4	CDS	623943	625688	.	+	0	Mb0545	PE_PGRS6a		PE-PGRS FAMILY PROTEIN [FIRST PART]	Mb0545, PE_PGRS6a, len: 581 aa. Equivalent to 5' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (92.7% identity in 564 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts,PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a.	Q7U1U2,A0A1R3XVM7	No				A0A1R3XVM7				IPR000084	Q7U1U2										
NC_002945.3	Mycobrowser_v4	CDS	625594	625821	.	+	0	Mb0546	PE_PGRS6b		PE-PGRS FAMILY PROTEIN [SECOND PART]	Mb0546, PE_PGRS6b, len: 75 aa. Equivalent to 3' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b.		No																			
NC_002945.3	Mycobrowser_v4	CDS	736753	737460	.	+	0	Mb0660	rplA		50s ribosomal protein l1 rpla	Mb0660, rplA, len: 235 aa. Equivalent to Rv0641,len: 235 aa, from Mycobacterium tuberculosis strain H37Rv (99.6% identity in 235 aa overlap). Probable rplA, 50S ribosomal protein L1, equivalent to NP_302281.1|NC_002677 50S ribosomal protein L1 from Mycobacterium leprae (235 aa). Also highly similar to others e.g. P3625|RL1_STRGR 50s ribosomal protein L1 from Streptomyces griseus (240 aa), FASTA scores: opt: 1081, E(): 0, (72.2% identity in 230 aa overlap); etc. BELONGS TO THE L1P FAMILY OF RIBOSOMAL PROTEINS.	X2BFN1,P59790,P59790	No	information pathways			P59790					X2BFN1,P59790					Rv0641		Rv0641			
NC_002945.3	Mycobrowser_v4	CDS	625717	626724	.	-	0	Mb0547c	fabH		3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III FABH (BETA-KETOACYL-ACP SYNTHASE III) (KAS III)	Mb0547c, fabH, len: 335 aa. Equivalent to Rv0533c,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). fabH (alternate gene name: mtFabH), 3-oxoacyl-[acyl-carrier protein] synthase III (EC 2.3.1.41) (see citations below), highly similar to others e.g. Q54206|FABH from STREPTOMYCES GLAUCESCENS (333 aa), FASTA scores: opt: 1109, E(): 0, (51.4% identity in 333 aa overlap); FABH_ECOLI|P24249 3-oxoacyl-[acyl-carrier-protein] synthase III (317 aa),FASTA scores: opt: 666, E(): 0, (37.1% identity in 318 aa overlap); etc. BELONGS TO THE FABH FAMILY. Note that previously known as fabH.	X2BF69,P0A575,P0A575	No				P0A575					X2BF69,P0A575										
NC_002945.3	Mycobrowser_v4	CDS	626806	627684	.	-	0	Mb0548c	menA		1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE MENA (DHNA-OCTAPRENYLTRANSFERASE)	Mb0548c, menA, len: 292 aa. Equivalent to Rv0534c,len: 292 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 292 aa overlap). Probable menA,1,4-dihydroxy-2-naphthoate octaprenyltransferase (EC 2.5.1.-), integral membrane protein, equivalent to Y13803|MLB1306_2|NP_302556.1 probable 4-dihydroxy-2-naphthoate octaprenyltransferase from Mycobacterium leprae (294 aa), FASTA scores: opt: 1509,E(): 0, (80.2% identity in 288 aa overlap). Also highly similar to others e.g. MENA_ECOLI|P32166|B3930 from Escherichia coli (308 aa), FASTA scores: opt: 495, E(): 2.9e-25, (36.3 identity in 289 aa overlap); etc. BELONGS TO THE MENA FAMILY.	X2BFB9,P65651,P65651	No				P65651					X2BFB9,P65651										
NC_002945.3	Mycobrowser_v4	CDS	627701	628495	.	+	0	Mb0549	pnp		PROBABLE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE PNP (MTA PHOSPHORYLASE)	Mb0549, pnp, len: 264 aa. Equivalent to Rv0535,len: 264 aa, from Mycobacterium tuberculosis strain H37R,(100.0% identity in 264 aa overlap). Probable pnp,5'-methylthioadenosine phosphorylase (EC 2.4.2.28), highly similar to others e.g. CAB90972.1|AL355832 putative methylthioadenosine phosphorylase from Streptomyces coelicolor (280 aa); etc. Also similar to Rv3307|deoD PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE (EC 2.4.2.1) from Mycobacterium tuberculosis (268 aa). BELONGS TO THE PNP/MTAP FAMILY 2 OF PHOSPHORYLASES. Gene name could be inappropriate.	Q7U1U1,A0A1R3XW63	No	intermediary metabolism and respiration			A0A1R3XW63				IPR000845,IPR001369,IPR010044	Q7U1U1					Rv0535		Rv0535			
NC_002945.3	Mycobrowser_v4	CDS	754753	755136	.	-	0	Mb0675c	vapc6		possible toxin vapc6	Mb0675c, -, len: 127 aa. Equivalent to Rv0656c,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 127 aa overlap). Conserved hypothetical protein, showing similarity with proteins from Mycobacterium tuberculosis e.g. Rv2757c, Rv2546,etc.	Q7U1J1,A0A1R3XX14	No	virulence, detoxification, adaptation			A0A1R3XX14				IPR002716,IPR022907	Q7U1J1					Rv0656c		Rv0656c			
NC_002945.3	Mycobrowser_v4	CDS	628492	629532	.	+	0	Mb0550	galE3		PROBABLE UDP-GLUCOSE 4-EPIMERASE GALE3 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE)	Mb0550, galE3, len: 346 aa. Equivalent to Rv0536,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Possible galE3,UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar to CAB76986.1|AL159178 putative epimerase from Streptomyces coelicolor (334 aa); and similar to other epimerases e.g. NP_436775.1|NC_003078 putative NDP-glucose dehydrataseepimerase protein from Sinorhizobium meliloti (368 aa); AF143772|AF143772_7 GepiA from Mycobacterium avium strain 2151 (353 aa), FASTA scores: opt: 577, E(): 3.9e-29, (36.6% identity in 352 aa overlap); GALE_METJA|Q57664 putative UDP-glucose 4-epimerase (305 aa), FASTA scores: opt: 300, E(): 1.6e-12, (30.9% identity in 343 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3634c, Rv3784, etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY. Note that previously known as galE2.	Q7U1U0,A0A1R3XVM2	No				A0A1R3XVM2				IPR001509,IPR008089,IPR016040	Q7U1U0										
NC_002945.3	Mycobrowser_v4	CDS	635660	636748	.	-	0	Mb0556c	menE		POSSIBLE O-SUCCINYLBENZOIC ACID--COA LIGASE MENE (OSB-COA SYNTHETASE) (O-SUCCINYLBENZOATE-COA SYNTHASE)	Mb0556c, menE, len: 362 aa. Equivalent to Rv0542c,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 362 aa overlap). Possible menE,O-succinylbenzoic acid-CoA ligase (EC 6.2.1.26), highly similar to Q50170|AAA63145.1|U15187|XCLB 4-Coumarate--CoA ligase from Mycobacterium leprae (352 aa), FASTA scores: opt: 1815, E(): 0, (78.9% identity in 351 aa overlap). Also similar to N-terminus of acid-CoA ligases e.g. NP_471116.1|NC_003212 O-succinylbenzoic acid-CoA ligase from Listeria innocua (469 aa); NP_390957.1|NC_000964 O-succinylbenzoic acid-CoA ligase from Bacillus subtilis (486 aa); MENE_HAEIN|P44565 O-succinylbenzoic acid-CoA ligase from Haemophilus influenzae (452 aa), FASTA scores: opt: 307, E(): 4.6e-12, (25.4% identity in 339 aa overlap); etc. Also some similarity with fadD proteins from Mycobacterium tuberculosis. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7U1T5,A0A1R3XXT9	No				A0A1R3XXT9				IPR000873,IPR020845,IPR025110	Q7U1T5										
NC_002945.3	Mycobrowser_v4	CDS	637454	638707	.	-	0	Mb0559c	pitA		PROBABLE LOW-AFFINITY INORGANIC PHOSPHATE TRANSPORTER INTEGRAL MEMBRANE PROTEIN PITA	Mb0559c, pitA, len: 417 aa. Equivalent to Rv0545c,len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 417 aa overlap). Probable pitA,low-affinity inorganic phosphate transporter, integral membrane protein, equivalent to Q50173|NP_302471.1 pitA from Mycobacterium leprae (414 aa), FASTA scores: opt: 2035, E(): 0, (76.3% identity in 418 aa overlap). Also highly similar to others e.g. CAB59461.1|AL132644 putative low-affinity phosphate transport protein from Streptomyces coelicolor (423 aa); PITA_ECOLI|P37308 low-affinity inorganic phosphate transporter from Escherichia coli (499 aa), FASTA scores: opt: 304, E(): 6.9e-10, (32.5 % identity in 234 aa overlap); etc. BELONGS TO THE PHO-4 FAMILY OF TRANSPORTERS, PIT SUBFAMILY.	X2BFE2,P59950,P59950	No				P59950					X2BFE2,P59950										
NC_002945.3	Mycobrowser_v4	CDS	649779	650915	.	+	0	Mb0572	mgta		mannosyltransferase mgta	Mb0572, pimB, len: 378 aa. Equivalent to Rv0557,len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). pimB (alternate gene name: mtfB), mannosyltransferase (EC 2.4.1.-) (see citation below), similar to other various transferases e.g. NP_243554.1|NC_002570 alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans (381 aa); NP_249533.1|NC_002516 probable glycosyl transferase from Pseudomonas aeruginosa (406 aa); NP_419573.1|NC_002696 glycosyl transferase, group 1 family protein, from Caulobacter crescentus (455 aa); etc. Also similar to Q55598 hypothetical 44.9 kDa protein from SYNECHOCYSTIS SP (409 aa), FASTA scores: opt: 703, E(): 0,(33.9% identity in 378 aa overlap); GPI3_YEAST|P32363 n-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (452 aa), FASTA scores: opt: 230, E(): 1.1e-07,(23.5% identity in 328 aa overlap).	Q7U1S2,A0A1R3XVQ4	No	lipid metabolism			A0A1R3XVQ4				IPR001296	Q7U1S2					Rv0557		Rv0557			
NC_002945.3	Mycobrowser_v4	CDS	640256	641200	.	-	0	Mb0562c	menB		naphthoate synthase menb (dihydroxynaphthoic acid synthetase) (dhna synthetase)	Mb0562c, menB, len: 314 aa. Equivalent to Rv0548c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable menB,naphthoate synthase (dihydroxynaphthonic acid synthase) (EC 4.1.3.36), equivalent to NP_302473.1|NC_002677 naphthoate synthase from Mycobacterium leprae (300 aa). Also similar to others e.g. MENB_ECOLI|P27290 naphthoate synthase from Escherichia coli (285 aa), FASTA scores: opt: 599, E(): 9.3e-33, (48.1 identity in 285 aa overlap); etc. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY.	Q7U1T0,A0A1R3XVP6	No				A0A1R3XVP6				IPR001753,IPR010198,IPR014748	Q7U1T0										
NC_002945.3	Mycobrowser_v4	CDS	641472	641609	.	-	0	Mb0563c	vapc3		CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]	Mb0563c, -, len: 45 aa. Similar to 3' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 45 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065,and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c.		No																			
NC_002945.3	Mycobrowser_v4	CDS	693129	693272	.	+	0	Mb0608	mce2Db		MCE-FAMILY PROTEIN MCE2DB [SECOND PART]	Mb0608, mce2Db, len: 47 aa. Equivalent to 3' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (95.7% identity in 47 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db.		No																			
NC_002945.3	Mycobrowser_v4	CDS	642339	644054	.	-	0	Mb0566c	fadD8		PROBABLE FATTY-ACID-COA LIGASE FADD8 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb0566c, fadD8, len: 571 aa. Equivalent to Rv0551c,len: 571 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 571 aa overlap). Probable fadD8,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 585, E(): 9.5e-30, (28.7% identity in 536 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Note other possible start sites exist downstream of this start.	Q7U1S7,A0A1R3XXU8	No				A0A1R3XXU8				IPR000873,IPR020845,IPR025110	Q7U1S7										
NC_002945.3	Mycobrowser_v4	CDS	645733	646713	.	+	0	Mb0568	menC		PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE)	Mb0568, menC, len: 326 aa. Equivalent to Rv0553,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 326 aa overlap). Probable menC,muconate cycloisomerase (EC 5.5.1.1), equivalent to NP_302476.1|NC_002677 putative isomerase/racemase from Mycobacterium leprae (334 aa). Also similar to other muconate cycloisomerases e.g. TCBD_PSESP|P27099 chloromuconate cycloisomerase (370 aa), FASTA scores: opt: 249, E(): 7.8e-09, (32.7% identity in 199 aa overlap). Also similar to O-succinylbenzoate-CoA synthases. BELONGS TO THE MANDELATE RACEMASE / MUCONATE LACTONIZING ENZYME FAMILY.	X2BFD4,P65426,P65426	No	intermediary metabolism and respiration			P65426					X2BFD4,P65426					Rv0553		Rv0553			
NC_002945.3	Mycobrowser_v4	CDS	646710	647498	.	+	0	Mb0569	bpoC		POSSIBLE PEROXIDASE BPOC (NON-HAEM PEROXIDASE)	Mb0569, bpoC, len: 262 aa. Equivalent to Rv0554,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Possible bpoC,peroxidase (non-haem peroxidase) (EC 1.11.1.-), equivalent to NP_302477.1|NC_002677 putative hydrolase from Mycobacterium leprae (265 aa). Also highly similar or similar to various hydrolases and peroxidases e.g. CAB38877.1|AL035707|T36181 probable hydrolase from Streptomyces coelicolor (272 aa); CAC48368.1|Y16952 putative hydrolase from Amycolatopsis mediterranei (284 aa); P29715|BPA2_STRAU non-haem bromoperoxidase bpo-a2 (bromide peroxidase) (EC 1.11.1.-) from Streptomyces aureofaciens (277 aa), FASTA scores: opt: 325, E(): 2.3e-15, (29.5% identity in 268 aa overlap); O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase (chloride peroxidase) (EC 1.11.1.10) from Streptomyces aureofaciens (278 aa); etc. Also similar to M. tuberculosis non-heme haloperoxidases and epoxide hydrolases e.g. Rv1938, Rv3617, etc.	Q7U1S5,A0A1R3XW80	No	virulence, detoxification, adaptation			A0A1R3XW80				IPR000073,IPR000639	Q7U1S5					Rv0554		Rv0554			
NC_002945.3	Mycobrowser_v4	CDS	650932	651636	.	+	0	Mb0573	menH		PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase)	Mb0573, menH, len: 234 aa. Equivalent to Rv0558,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable menH (alternate gene name: menG), ubiquinone/menaquinone biosynthesis methlytransferase (2-heptaprenyl-1,4-naphthoquinone methyltransferase) (EC 2.1.1.-), equivalent to NP_302480.1|NC_002677 putative ubiquinone/menaquinone biosynthesis methyltransferase from Mycobacterium leprae (238 aa). Also highly similar to others e.g. CAB44537.1|AL078618|T34630 from Streptomyces coelicolor (231 aa); UBIE_ECOLI|P27851 from Escherichia coli strain K12 (251 aa), FASTA scores: opt: 421, E(): 1.2e-21, (43.2% identity in 227 aa overlap); GRC2_BACSU|P31113 from Bacillus subtilis (233 aa), FASTA scores: opt: 345, E(): 1.4e-16, (34.6% identity in 231 aa overlap); etc. BELONGS TO THE UBIE FAMILY. Note that previously known as ubiE.	X2BFD8,P0A639,P0A639	No	intermediary metabolism and respiration			P0A639					X2BFD8,P0A639					Rv0558		Rv0558			
NC_002945.3	Mycobrowser_v4	CDS	760301	760573	.	+	0	Mb0683	vapb8		possible antitoxin vapb8	Mb0683, -, len: 90 aa. Equivalent to Rv0664, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein.	Q7U1I3,A0A1R3XW14	No	virulence, detoxification, adaptation			A0A1R3XW14					Q7U1I3					Rv0664		Rv0664			
NC_002945.3	Mycobrowser_v4	CDS	654014	655021	.	+	0	Mb0577	grcC1		PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	Mb0577, grcC1, len: 335 aa. Equivalent to Rv0562,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Probable grcC1,polyprenyl diphosphate synthetase (EC 2.5.1.-), equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (325 aa); Rv3383c,Rv3398c, etc. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY.	Q7U1R8,A0A1R3XWR5	No				A0A1R3XWR5				IPR000092,IPR008949,IPR017446	Q7U1R8										
NC_002945.3	Mycobrowser_v4	CDS	655122	655982	.	+	0	Mb0578	htpX		PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX	Mb0578, htpX, len: 286 aa. Equivalent to Rv0563,len: 286 aa (alternative start at position 654006), from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 286 aa overlap). Probable htpX, protease heat shock protein X (EC 3.4.24.-) (transmembrane protein),equivalent to NP_302484.1|NC_002677 putative peptidase from Mycobacterium leprae (287 aa). Also highly similar to others e.g. CAC08262.1|AL392146 putative peptidase from Streptomyces coelicolor (287 aa); NP_387431.1|NC_003047 PUTATIVE PROTEASE TRANSMEMBRANE PROTEIN from Sinorhizobium meliloti (319 aa); NP_105051.1|NC_002678 heat shock protein (htpX) from Mesorhizobium loti (336 aa); NP_248692.1|NC_000909|U67608|MJU67608_8 heat shock protein HtpX, possibly protease (htpX) from Methanococcus jannaschii (284 aa), FASTA scores: opt: 660, E(): 0, (46.5 identity in 245 aa overlap). Continuation of MTCY25D10.42. TBparse score is 0.887. BELONGS TO PEPTIDASE FAMILY M48 (ZINC METALLOPROTEASE). COFACTOR: Zinc.	X2BFE3,P65816,P65816	No	virulence, detoxification, adaptation			P65816					X2BFE3,P65816					Rv0563		Rv0563			
NC_002945.3	Mycobrowser_v4	CDS	656167	657192	.	-	0	Mb0579c	gpdA1		PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA1 (NAD(P)H-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) (NAD(P)H-DEPENDENT DIHYDROXYACETONE-PHOSPHATE REDUCTASE)	Mb0579c, gpdA1, len: 341 aa. Equivalent to Rv0564c,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 341 aa overlap). Possible gpdA1(alternate gene names: gpsA, glyC),glycerol-3-phosphate dehydrogenase [NAD(P)+] dependant (EC 1.1.1.94), similar to many other glycerol-3-phosphate dehydrogenases e.g. P46919|GPDA_BACSU from Bacillus subtilis (345 aa), FASTA scores: opt: 731, E(): 0, (37.3% identity in 332 aa overlap); etc. Also similar to Rv2982c|gpdA2|MTCY349.05|Z83018|MTCY349_5 from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 740, E(): 0, (40.4% identity in 322 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY.	X2BFG8,P64189,P64189	No				P64189					X2BFG8,P64189										
NC_002945.3	Mycobrowser_v4	CDS	760570	760908	.	+	0	Mb0684	vapc8		possible toxin vapc8	Mb0684, -, len: 112 aa. Equivalent to Rv0665, len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Conserved hypothetical protein, similar to Rv0627 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), and showing similarity with Rv0595c.	Q7U1I2,A0A1R3XY60	No	virulence, detoxification, adaptation			A0A1R3XY60				IPR002716	Q7U1I2					Rv0665		Rv0665			
NC_002945.3	Mycobrowser_v4	tRNA	659352	659432	.	+	0	tyrT	tyrT		tRNA-Tyr	tyrT, len: 81 nt. Equivalent to tyrT, len: 81 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 81 nt overlap). tRNA-Tyr, anticodon gta,length = 81		No																			
NC_002945.3	Mycobrowser_v4	CDS	780246	780674	.	-	0	Mb0696c	mmpS5		POSSIBLE CONSERVED MEMBRANE PROTEIN MMPS5	Mb0696c, mmpS5, len: 142 aa. Equivalent to Rv0677c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Possible mmpS5,conserved membrane protein (see first citation below),highly similar to other Mycobacterial proteins e.g. P54880|MMS4_MYCLE PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 443,E(): 1.4e-23, (47.1% identity in 155 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis. BELONGS TO THE MMPS FAMILY. TBparse score is 0.901.	X2BFV2,P65381,P65381	No				P65381					X2BFV2,P65381										
NC_002945.3	Mycobrowser_v4	CDS	704731	705132	.	+	0	Mb0625	vapc28		possible toxin vapc28. contains pin domain.	Mb0625, -, len: 133 aa. Equivalent to Rv0609, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to several Mycobacterium tuberculosis hypothetical proteins e.g. YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37 CONSERVED HYPOTHETICAL PROTEIN (139 aa), FASTA scores: opt: 262,E(): 8.1e-12, (39.1% identity in 128 aa overlap); MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05 CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA score: (42.9% identity in 126 aa overlap), Rv0565c, Rv3854c, etc.	X2BFL4,P67239,P67239	No	virulence, detoxification, adaptation			P67239					X2BFL4,P67239					Rv0609		Rv0609			
NC_002945.3	Mycobrowser_v4	CDS	660693	662111	.	+	0	Mb0583	cyp135B1		POSSIBLE CYTOCHROME P450 135B1 CYP135B1	Mb0583, cyp135B1, len: 472 aa. Equivalent to Rv0568, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 472 aa overlap). Possible cyp135B1, cytochrome P450 (EC 1.14.-.-), similar to putative cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. P29980|CPXN_ANASP PROBABLE CYTOCHROME P450 from Anabaena sp. strain PCC 7120 (459 aa), FASTA scores: opt: 525, E(): 7.2e-27, (31.9% identity in 417 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0327c|NP_214841.1|NC_000962|CYP135A1|MT0342|MTCY63.32c PUTATIVE CYTOCHROME P450 (449 aa), FASTA scores: opt: 1080, E(): 0, (40.5% identity in 444 aa overlap); Rv3685c|NP_218202.1|NC_000962 PUTATIVE CYTOCHROME P450 (476 aa); Rv0136|NP_214650.1|NC_000962 PUTATIVE CYTOCHROME P450 (441 aa); etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086).	X2BFF0,P63716,P63716	No	intermediary metabolism and respiration			P63716					X2BFF0,P63716					Rv0568		Rv0568			
NC_002945.3	Mycobrowser_v4	CDS	662538	664670	.	+	0	Mb0585	nrdZ		PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (LARGE SUBUNIT) NRDZ (RIBONUCLEOTIDE REDUCTASE)	Mb0585, nrdZ, len: 710 aa. Equivalent to 5' end of Rv0570, len: 692 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 631 aa overlap). Probable nrdZ, ribonucleoside-diphosphate reductase, large subunit (EC 1.17.4.-), highly similar to others e.g. NP_070492.1|NC_000917|NRD|AE000988_11 ribonucleotide reductase from Archaeoglobus fulgidus (752 aa), FASTA scores: opt: 2001, E(): 0, (52.5% identity in 562 aa overlap) (N-terminus shorter); U73619|TAU73619_1|T37459 ribonucleotide reductase from Thermoplasma acidophilum (857 aa), FASTA scores: opt: 1678, E(): 0, (43.7% identity in 723 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE LARGE CHAIN FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U1R4,A0A1R3XVR3	No				A0A1R3XVR3				IPR000788,IPR005144,IPR008926,IPR013344,IPR013509	Q7U1R4										
NC_002945.3	Mycobrowser_v4	CDS	679632	680318	.	-	0	Mb0598c	lpqN		PROBABLE CONSERVED LIPOPROTEIN LPQN	Mb0598c, lpqN, len: 228 aa. Equivalent to Rv0583c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). Probable lpqN,conserved lipoprotein, equivalent to AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein precursor from Mycobacterium kansasii (225 aa), FASTA scores: opt: 945, E(): 0, (62.7% identity in 228 aa overlap); and similar to others from Mycobacteria e.g. Rv0040c and Rv1016c from Mycobacterium tuberculosis. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U1Q2,A0A1R3XW97	No				A0A1R3XW97				IPR019674	Q7U1Q2										
NC_002945.3	Mycobrowser_v4	CDS	667093	668484	.	-	0	Mb0588c	pncb2		nicotinic acid phosphoribosyltransferase pncb2	Mb0588c, -, len: 463 aa. Equivalent to Rv0573c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins and some nicotinate phosphoribosyltransferases e.g. NP_213718.1|NC_000918 hypothetical protein from Aquifex aeolicus (426 aa); AL109962|T36953|SCJ1.20 conserved hypothetical protein from Streptomyces coelicolor (438 aa), FASTA scores: opt: 1089, E(): 0, (49.4% identity in 385 aa overlap); P_391053.1|Z99120|BSUB0017_57|NC_000964 protein similar to nicotinate phosphoribosyltransferase from Bacillus subtilis (490 aa), FASTA scores: opt: 955, E():0, (43.5% identity in 356 aa overlap); etc. Also similar to Q10641|Y03F_MYCTU|MTCY130.15c|Rv1330c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (509 aa), FASTA scores: opt: 761, E(): 0, (38.4% identity in 437 aa overlap).	Q7U1R1,A0A1R3XW93	No	intermediary metabolism and respiration			A0A1R3XW93				IPR002638,IPR006405,IPR007229	Q7U1R1					Rv0573c		Rv0573c			
NC_002945.3	Mycobrowser_v4	CDS	672409	673194	.	+	0	Mb0592	TB27.3		conserved protein tb27.3	Mb0592, TB27.3, len: 261 aa. Equivalent to Rv0577,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). TB27.3, conserved hypothetical protein. Corresponds to O53774|CF30_MYCTU 27 KD ANTIGEN CFP30B from Mycobacterium tuberculosis culture filtrate (260 aa), FASTA scores: opt: 1781, E(): 0,(100.0% identity in 260 aa overlap). Also similar to several hypothetical proteins and hydroxylases from Steptomyces sp. e.g. T35032 probable hydroxylase from Streptomyces coelicolor (263 aa); Q55078 orfA gene product from Streptomyces sp. (275 aa), FASTA scores: E(): 1.5e-1 9, (38.6% identity in 264 aa overlap); D89734_1|P95754 DNA for SgaA SGAA PROTEIN from Streptomyces griseus; and SC9B10_20 from Streptomyces coelicolor (267 aa), FASTA score: (38.9 identity in 252 aa overlap). Also similar to Rv0911|MTCY21C12.05 from Mycobacterium tuberculosis (257 aa), FASTA scores: E(): 1.1e-20, (32.0% identity in 259 aa overlap).	X2BFF7,P0A5N9	No				P0A5N9					X2BFF7										
NC_002945.3	Mycobrowser_v4	CDS	685653	686375	.	+	0	Mb0601	mce2r		probable transcriptional regulatory protein mce2r (gntr-family)	Mb0601, -, len: 240 aa. Equivalent to Rv0586, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable transcriptional regulator, GntR family, similar to many e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase operon regulatory protein from Escherichia coli (258 aa),FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in 232 aa overlap); etc. Also similar to other M. tuberculosis transcriptional regulators GntR proteins e.g. Rv3060c, Rv0792c, etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature and probable helix-turn helix motif from aa 35-56 (Score 1531, +4.40 SD).	X2BFB8,P67742,P67742	No	regulatory proteins			P67742					X2BFB8,P67742					Rv0586		Rv0586			
NC_002945.3	Mycobrowser_v4	CDS	673239	677159	.	-	0	Mb0593c	PE_PGRS7		pe-pgrs family protein pe_pgrs7	Mb0593c, PE_PGRS7, len: 1306 aa. Equivalent to Rv0578c, len: 1306 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1306 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many other PGRS proteins e.g. MTCY493.04|Z95844 from M. tuberculosis (1329 aa), FASTA scores: opt: 3994, E(): 0,(54.6% identity in 1375 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures possibly fortuitously.	Q7U1Q7,A0A1R3XVR5	No				A0A1R3XVR5				IPR000084	Q7U1Q7										
NC_002945.3	Mycobrowser_v4	CDS	678953	679168	.	+	0	Mb0596	vapb26		possible antitoxin vapb26	Mb0596, -, len: 71 aa. Equivalent to Rv0581, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Conserved hypothetical protein, showing weak similarity to several Mycobacterium tuberculosis proteins including P95003|Z83863|Rv2550c|MTCY159_6 CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA scores: opt: 93, E(): 3.2, (25.7% identity in 70 aa overlap); Rv2871; Rv1241; etc. Also shows weak similarity to X05648|SGSPH_1 from Streptomyces glaucescens (77 aa), FASTA scores: opt: 92, E(): 3.6,(35.4% identity in 65 aa overlap).	Q7U1Q4,A0A1R3XWT4	No	virulence, detoxification, adaptation			A0A1R3XWT4				IPR002145,IPR010985,IPR013321	Q7U1Q4					Rv0581		Rv0581			
NC_002945.3	Mycobrowser_v4	CDS	679165	679572	.	+	0	Mb0597	vapc26		possible toxin vapc26. contains pin domain.	Mb0597, -, len: 135 aa. Equivalent to Rv0582, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Hypothetical unknown protein.	Q7U1Q3,A0A1R3XVW6	No	virulence, detoxification, adaptation			A0A1R3XVW6				IPR002716,IPR022907	Q7U1Q3					Rv0582		Rv0582			
NC_002945.3	Mycobrowser_v4	CDS	686372	687169	.	+	0	Mb0602	yrbE2A		CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE2A	Mb0602, yrbE2A, len: 265 aa. Equivalent to Rv0587,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). yrbE2A, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 311, E(): 1.8e-83, (24.2% identity in 265 aa overlap); NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); etc.	Q7U1P9,A0A1R3XVS7	No				A0A1R3XVS7				IPR003453	Q7U1P9										
NC_002945.3	Mycobrowser_v4	CDS	687171	688058	.	+	0	Mb0603	yrbE2B		CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE2B	Mb0603, yrbE2B, len: 295 aa. Equivalent to Rv0588,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). yrbE2B, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kd protein from Escherichia coli (260 aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 % identity in 267 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protei from Haemophilus influenzae (261 aa),FASTA scores: opt: 234, E(): 6.3e-08, (24.2% identity in 215 aa overlap); NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); etc.	Q7U1P8,A0A1R3XVS8	No				A0A1R3XVS8				IPR003453	Q7U1P8										
NC_002945.3	Mycobrowser_v4	CDS	688064	689278	.	+	0	Mb0604	mce2A		MCE-FAMILY PROTEIN MCE2A	Mb0604, mce2A, len: 404 aa. Equivalent to Rv0589,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 404 aa overlap). mce2A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Also highly similar, but longer 21 aa, to P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1324, E(): 0, (62.6% identity in 436 aa overlap). Contains a possible N-terminal signal or anchor sequence. Note that previously known as mce2.	Q7U1P7,A0A1R3XVT2	No				A0A1R3XVT2				IPR003399,IPR005693,IPR024516	Q7U1P7										
NC_002945.3	Mycobrowser_v4	CDS	689275	690306	.	+	0	Mb0605	mce2B		mce-family related protein	Mb0605, mce2B, len: 343 aa. Equivalent to Rv0590 and Rv0590A, len: 275 aa and 84 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 255 aa overlap and 100.0% identity in 84 aa overlap). mce2B: belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); P45391|YRBD_ECOLI hypothetical 19.6 kd protein from Escherichia coli (183 aa), FASTA scores: opt: 160, E(): 0.00099, (28.3% identity in 166 aa overlap); P45029|YRBD_HAEIN|HI1085 hypothetical protein from Haemophilus influenzae (167 aa), FASTA scores: opt: 135,E():0.035, (25.9% identity in 143 aa overlap); etc. Contains possible N-terminal signal or anchor sequence. Rv0590A: probable continuation of mce2B|Rv0590. Can find no frameshift to account for this. Possible nucleotide G missing at 688793 as there are 5 in Mycobacterium bovis but only 4 in CDC1551. Strong similarity to C-terminus of other Mce proteins e.g. AL583926|AL583926_38 from Mycobacterium leprae strain TN (346 aa), FASTA scores: E(): 1.2e-20, (67.85% identity in 84 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes,most likely to be linked. In Mycobacterium bovis, an in-frame insertion of a single base (*-g) leads to a single product.	Q7U1P6,A0A1R3XXY3	No	virulence, detoxification, adaptation			A0A1R3XXY3				IPR003399,IPR005693	Q7U1P6					Rv0590		Rv0590			
NC_002945.3	Mycobrowser_v4	CDS	690303	691748	.	+	0	Mb0606	mce2C		MCE-FAMILY PROTEIN MCE2C	Mb0606, mce2C, len: 481 aa. Equivalent to Rv0591,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 481 aa overlap). mce2C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and may contain N-terminal signal or anchor sequence. Has highly Pro-rich C-terminus.	Q7U1P5,A0A1R3XWU4	No				A0A1R3XWU4				IPR003399,IPR005693,IPR008360	Q7U1P5										
NC_002945.3	Mycobrowser_v4	CDS	691745	693181	.	+	0	Mb0607	mce2Da		MCE-FAMILY PROTEIN MCE2DA [FIRST PART]	Mb0607, mce2Da, len: 478 aa. Equivalent to 5' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 471 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information),highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db.	Q7U1P4,A0A1R3XVX2	No				A0A1R3XVX2				IPR003399,IPR005693	Q7U1P4										
NC_002945.3	Mycobrowser_v4	CDS	693269	693835	.	+	0	Mb0609	lprL		POSSIBLE MCE-FAMILY LIPOPROTEIN LPRL (MCE-FAMILY LIPOPROTEIN MCE2E)	Mb0609, lprL, len: 188 aa. Equivalent to 5' end of Rv0593, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 188 aa overlap). Possible lprL (alternate gene name: mce2E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (c-t) introducing a stop codon,leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (188 aa versus 402 aa).	Q7U1P3,A0A1R3XWA6	No				A0A1R3XWA6				IPR003399,IPR005693	Q7U1P3										
NC_002945.3	Mycobrowser_v4	CDS	694482	696032	.	+	0	Mb0610	mce2F		MCE-FAMILY PROTEIN MCE2F	Mb0610, mce2F, len: 516 aa. Equivalent to Rv0594,len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 516 aa overlap). mce2F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Contains possible N-terminal signal or anchor sequence.	Q7U1P2,A0A1R3XVT6	No				A0A1R3XVT6				IPR003399,IPR005693	Q7U1P2										
NC_002945.3	Mycobrowser_v4	CDS	696084	696476	.	-	0	Mb0611c	vapc4		possible toxin vapc4	Mb0611c, -, len: 130 aa. Equivalent to Rv0595c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Conserved hypothetical protein, similar to other conserved hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112 aa) from Mycobacterium tuberculosis; and STBB_PSESM|Q52562 plasmid stability protein from Pseudomonas syringae (139 aa), FASTA scores: opt: 131, E(): 0.0035, (35.2% identity in 88 aa overlap).	Q7U1P1,A0A1R3XVX0	No	virulence, detoxification, adaptation			A0A1R3XVX0				IPR002716,IPR022907	Q7U1P1					Rv0595c		Rv0595c			
NC_002945.3	Mycobrowser_v4	CDS	696473	696730	.	-	0	Mb0612c	vapb4		possible antitoxin vapb4	Mb0612c, -, len: 85 aa. Equivalent to Rv0596c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, highly similar in part to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv0626, Rv3181c,Rv3385c, Rv3407, etc.	Q7U1P0,A0A1R3XVV0	No	virulence, detoxification, adaptation			A0A1R3XVV0				IPR006442	Q7U1P0					Rv0596c		Rv0596c			
NC_002945.3	Mycobrowser_v4	CDS	698399	698812	.	-	0	Mb0614c	vapc27		possible toxin vapc27. contains pin domain.	Mb0614c, -, len: 137 aa. Equivalent to Rv0598c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein; similar to Rv2596|Y0B5_MYCTU|Q50625 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (134 aa), FASTA scores: opt: 254, E(): 8.2e-12, (41.5% identity in 130 aa overlap).	Q7U1N8,A0A1R3XVT7	No	virulence, detoxification, adaptation			A0A1R3XVT7				IPR002716,IPR022907	Q7U1N8					Rv0598c		Rv0598c			
NC_002945.3	Mycobrowser_v4	CDS	698809	699045	.	-	0	Mb0615c	vapb27		possible antitoxin vapb27	Mb0615c, -, len: 78 aa. Equivalent to Rv0599c, len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Conserved hypothetical protein, similar to Rv2595|Y0B6_MYCTU|Q50626 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (81 aa), FASTA scores: opt: 160, E(): 6.2e-07, (35.8% identity in 81 aa overlap). N-terminus shows stong similarity with N-terminus of NP_104908.1|NC_002678 hypothetical protein from Mesorhizobium loti (89 aa).	Q7U1N7,A0A1R3XVT8	No	virulence, detoxification, adaptation			A0A1R3XVT8				IPR007159	Q7U1N7					Rv0599c		Rv0599c			
NC_002945.3	Mycobrowser_v4	CDS	700283	701044	.	-	0	Mb0618c	tcrA		two component dna binding transcriptional regulatory protein tcra	Mb0618c, tcrA, len: 253 aa. Equivalent to Rv0602c,len: 253 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 253 aa overlap). Probable tcrA,two-component DNA-binding response regulator, highly similar to others e.g. NP_107959.1|NC_002678 two-component response regulator from Mesorhizobium loti (239 aa); etc. Also similar to many other Mycobacterium tuberculosis two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c RESPONSE REGULATOR HOMOLOG TRCR (TCRV) (257 aa), FASTA score: (47.4 identity in 232 aa overlap); etc.	Q7U1N4,A0A1R3XVY5	No				A0A1R3XVY5				IPR001789,IPR001867,IPR011006,IPR011991	Q7U1N4										
NC_002945.3	Mycobrowser_v4	CDS	701484	702434	.	+	0	Mb0620	lpqO		PROBABLE CONSERVED LIPOPROTEIN LPQO	Mb0620, lpqO, len: 316 aa. Equivalent to Rv0604,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 316 aa overlap). Probable lpqO,conserved lipoprotein, highly similar to Rv2999|lppY PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (321 aa), FASTA scores: opt: 1153, E(): 0, (53.2% identity in 312 aa overlap). Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U1N2,A0A1R3XVU5	No	cell wall and cell processes			A0A1R3XVU5				IPR011094	Q7U1N2					Rv0604		Rv0604			
NC_002945.3	Mycobrowser_v4	CDS	712781	713965	.	+	0	Mb0635	galT		probable galactose-1-phosphate uridylyltransferase galtb [second part]	Mb0635, galT, len: 394 aa. Equivalent to Rv0618 and Rv0619, len: 231 aa (probable partial CDS) and 181 aa (probable partial CDS), from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 219 aa overlap and 99.4% identity in 174 aa overlap). Rv0618: Probable galT', first part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), highly similar to N-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa),FASTA scores: opt: 296, E(): 1.4e-11, (50.8% identity in 177 aa overlap); etc. Also highly similar to N-terminal half of some UDP glucose--hexose-1-phosphate uridylyltransferases (EC 2.7.7.12). N-terminal 28 aa similar to MTCY20H11.08|Rv0627|MTCY20H11.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), FASTA score: (71.4% identity in 28 aa overlap). BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE >FAMILY 1. Rv0619: Probable 'galT, second part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10),highly similar to C-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa),FASTA scores: opt: 416, E(): 5.2e-22, (43.0% identity in 186 aa overlap), etc. BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FAMILY 1. Cosmid sequence is correct but there may be a frameshift mutation in this region which would allow the two ORFS to be joined. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts,galT' and 'galT. In Mycobacterium bovis, an in-frame insertion of a single base (*-a) leads to a single product.	Q7U1L8,A0A1R3XWX5	No	intermediary metabolism and respiration			A0A1R3XWX5				IPR001937,IPR005849,IPR005850,IPR011146,IPR019779	Q7U1L8					Rv0618		Rv0618			
NC_002945.3	Mycobrowser_v4	CDS	757104	757541	.	-	0	Mb0680c	vapc7		possible toxin vapc7	Mb0680c, -, len: 145 aa. Equivalent to Rv0661c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2863|MTV003.09|MTV003_7 (126 aa), FASTA scores: E(): 0.00087, (30.4% identity in 125 aa overlap),Rv0749|MTV041.23 (163 aa); Rv0277c, Rv2530c, etc.	Q7U1I6,A0A1R3XW16	No	virulence, detoxification, adaptation			A0A1R3XW16				IPR002716,IPR022907	Q7U1I6					Rv0661c		Rv0661c			
NC_002945.3	Mycobrowser_v4	CDS	713962	715053	.	+	0	Mb0636	galK		PROBABLE GALACTOKINASE GALK (GALACTOSE KINASE)	Mb0636, galK, len: 363 aa. Equivalent to Rv0620,len: 363 aa, from Mycobacterium tuberculosis strain H37RV,(99.7% identity in 362 aa overlap). Probable galK,galactokinase (EC 2.7.1.6), similar to others e.g. P13227|GAL1_STRLI GALACTOKINASE from Streptomyces lividans (397 aa); P06976|GAL1_ECOLI galactokinase from Escherichia coli (381 aa), FASTA scores: opt: 669, E(): 0, (35.9% identity in 365 aa overlap); etc. Contains PS00106 Galactokinase signature and PS00560 Serine carboxypeptidases, histidine active site. BELONGS TO THE GHMP KINASE FAMILY. GALK SUBFAMILY.	X2BFN2,Q7U1L7,Q7U1L7	No	intermediary metabolism and respiration			Q7U1L7					X2BFN2,Q7U1L7					Rv0620		Rv0620			
NC_002945.3	Mycobrowser_v4	CDS	717656	717910	.	+	0	Mb0639	vapb30		possible antitoxin vapb30	Mb0639, -, len: 84 aa. Equivalent to Rv0623, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Conserved hypothetical protein, highly similar to NP_384911.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (84 aa). Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 CONSERVED HYPOTHETICAL PROTEIN (70 aa), FASTA score: (73.5% identity in 68 aa overlap); MTCY4C12_25|Rv0608|MTCY19H5.14c CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA score: (73.5 identity in 68 aa overlap); etc.	Q7U1L4,A0A1R3XW02	No	virulence, detoxification, adaptation			A0A1R3XW02				IPR011660	Q7U1L4					Rv0623		Rv0623			
NC_002945.3	Mycobrowser_v4	CDS	717910	718305	.	+	0	Mb0640	vapc30		possible toxin vapc30. contains pin domain.	Mb0640, -, len: 131 aa. Equivalent to Rv0624, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, highly similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1741, Rv0609,Rv2759c,Rv0565c, Rv3854c, Rv3083, etc.	X2BFK5,P67241,P67241	No	virulence, detoxification, adaptation			P67241					X2BFK5,P67241					Rv0624		Rv0624			
NC_002945.3	Mycobrowser_v4	CDS	757538	757906	.	-	0	Mb0681c	vapb7		possible antitoxin vapb7	Mb0681c, -, len: 122 aa. Equivalent to Rv0662c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Conserved hypothetical protein, showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2871, Rv1241, Rv2550c, etc.	Q7U1I5,A0A1R3XW11	No	virulence, detoxification, adaptation			A0A1R3XW11					Q7U1I5					Rv0662c		Rv0662c			
NC_002945.3	Mycobrowser_v4	CDS	721251	722978	.	-	0	Mb0645c	recD		PROBABLE EXONUCLEASE V (ALPHA CHAIN) RECD (EXODEOXYRIBONUCLEASE V ALPHA CHAIN) (EXODEOXYRIBONUCLEASE V POLYPEPTIDE)	Mb0645c, recD, len: 575 aa. Equivalent to Rv0629c,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 575 aa overlap). Probable recD,exonuclease V, alpha chain (exodeoxyribonuclease V, alpha chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_3|AAD46809.1|recD Escherichia coli RecD protein homolog from Mycobacterium smegmatis (554 aa); P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease v 67kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V ALPHA CHAIN) from Escherichia coli strain K12 (608 aa), FASTA scores: opt: 512, E(): 1.9e-24, (36.9% identity in 582 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). CONSIST OF THREE SUBUNITS; RECB|Rv0630c,RECC|Rv0631c AND RECD.	Q7U1L1,A0A1R3XWY4	No				A0A1R3XWY4				IPR006344,IPR027417,IPR027785	Q7U1L1										
NC_002945.3	Mycobrowser_v4	CDS	722975	723679	.	-	0	Mb0646c	recBb		PROBABLE EXONUCLEASE V (BETA CHAIN) RECBB [SECOND PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE)	Mb0646c, recBb, len: 234 aa. Equivalent to 3' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 234 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V, beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb.		No																			
NC_002945.3	Mycobrowser_v4	CDS	723565	726258	.	-	0	Mb0647c	recBa		PROBABLE EXONUCLEASE V (BETA CHAIN) RECBA [FIRST PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE)	Mb0647c, recBa, len: 897 aa. Equivalent to 5' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 868 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V,beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb.	Q7U1L0,A0A1R3XWD4	No				A0A1R3XWD4				IPR000212,IPR004586,IPR011335,IPR011604,IPR014016,IPR014017,IPR027417	Q7U1L0										
NC_002945.3	Mycobrowser_v4	CDS	726258	729551	.	-	0	Mb0648c	recC		PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC (EXODEOXYRIBONUCLEASE V GAMMA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE)	Mb0648c, recC, len: 1097 aa. Equivalent to Rv0631c,len: 1097 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1097 aa overlap). Probable recC,exonuclease V, gamma chain (exodeoxyribonuclease V, gamma chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein homolog from Mycobacterium smegmatis (1085 aa); P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease v 125 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V GAMMA CHAIN) from Escherichia coli strain K12 (1122 aa), FASTA scores: opt: 954, E(): 0, (29.2% identity in 1109 aa overlap); etc. CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC AND RECD|Rv0629c.	Q7U1K9,A0A1R3XVX6	No				A0A1R3XVX6				IPR006697,IPR011335,IPR013986,IPR027417	Q7U1K9										
NC_002945.3	Mycobrowser_v4	CDS	805511	806104	.	+	0	Mb0726	rplV		50s ribosomal protein l22 rplv	Mb0726, rplV, len: 197 aa. Equivalent to Rv0706,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 197 aa overlap). Probable rplV, 50S ribosomal protein L22, equivalent to O06115|RL22_MYCSM 50S RIBOSOMAL PROTEIN L22 from Mycobacterium smegmatis (153 aa); MBS10OPER_7 50S RIBOSOMAL PROTEIN L22 from Mycobacterium bovis BCG; and MLCB2492_7 50S ribosomal protein L22 from Mycobacterium leprae (175 aa). Also highly similar to others e.g. CAB82075.1|AL161803 50S ribosomal protein L22 from Streptomyces coelicolor (125 aa); P42060|RL22_BACSU 50s ribosomal protein L22 from Bacillus subtilis (113 aa), FASTA scores: opt: 368, E(): 2.4e-13, (52.8% identity in 108 aa overlap); etc. Contains PS00464 Ribosomal protein L22 signature, and contains repetitive sequence at C-terminus. BELONGS TO THE L22P FAMILY OF RIBOSOMAL PROTEINS.	X2BFW8,P61180,P61180	No	information pathways			P61180					X2BFW8,P61180					Rv0706		Rv0706			
NC_002945.3	Mycobrowser_v4	CDS	729828	730523	.	-	0	Mb0649c	echA3		PROBABLE ENOYL-COA HYDRATASE ECHA3 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb0649c, echA3, len: 231 aa. Equivalent to Rv0632c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Probable echA3,enoyl-CoA hydratase (EC 4.2.1.17), almost identical to the MTU88877_1 enoyl-coA hydratase of Mycobacterium tuberculosis field isolate NTI64719, FASTA score: (92.4% identity in 184 aa overlap). Also similar to others e.g. P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores: opt: 206, E(): 6.3e-07, (31.5% identity in 232 aa overlap); etc.	Q7U1K8,A0A1R3XW12	No				A0A1R3XW12				IPR001753	Q7U1K8										
NC_002945.3	Mycobrowser_v4	tRNA	732839	732912	.	+	0	metT	metT		tRNA-Met	metT, len: 74 nt. Equivalent to metT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Met, anticodon cat.		No																			
NC_002945.3	Mycobrowser_v4	CDS	732948	733115	.	+	0	Mb0653	rpmG2		50s ribosomal protein l33 rpmg2	Mb0653, rpmG2, len: 55 aa. Equivalent to Rv0634B,len: 55 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 55 aa overlap). Probable rpmG2, 50S ribosomal protein L33. Note that Mycobacterium tuberculosis has a second rpmG gene: P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1 PUTATIVE 50S RIBOSOMAL PROTEIN L33 (55 aa), FASTA scores: opt: 391,E(): 2.9e-25, (100.0% identity in 55 aa overlap). BELONGS TO THE L33P FAMILY OF RIBOSOMAL PROTEINS.	X2BFN0,P0A5W3,P0A5W3	No				P0A5W3					X2BFN0,P0A5W3										
NC_002945.3	Mycobrowser_v4	CDS	733166	733642	.	+	0	Mb0654	hada		(3r)-hydroxyacyl-acp dehydratase subunit hada	Mb0654, -, len: 158 aa. Equivalent to Rv0635, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Conserved hypothetical protein, equivalent to NP_302287.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (159 aa); and highly similar to YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa), FASTA scores: opt: 387, E(): 5.9e-21, (43.4% identity in 145 aa overlap). Also similar CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). And highly similar to two hypothetical proteins from Mycobacterium tuberculosis: Rv0504c|YV31_MYCTU|Q11168 (166 aa), FASTA scores: opt: 405, E(): 3.2e-22, (45.0% identity in 140 aa overlap); and Rv0637|MTY20H10_19 (2 ORFs downstream) (166 aa), FASTA score: (48.7% identity in 150 aa overlap).	X2BFG4,Q7U1K4	No	intermediary metabolism and respiration			Q7U1K4					X2BFG4					Rv0635		Rv0635			
NC_002945.3	Mycobrowser_v4	CDS	733629	734057	.	+	0	Mb0655	hadb		(3r)-hydroxyacyl-acp dehydratase subunit hadb	Mb0655, -, len: 142 aa. Equivalent to Rv0636, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 142 aa overlap). Conserved hypothetical protein, equivalent to NP_302286.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (142 aa). Also highly similar to CAB77411.1|AL160431|SCD82.08 hypothetical protein from Streptomyces coelicolor (142 aa); and similar to others e.g. U28943|CELE04F6_3 from Caenorhabditis elegans (cosmid E04) (298 aa), FASTA scores: opt: 167, E(): 0.00064, (31.6 identity in 117 aa overlap).	Q7U1K3,A0A1R3XWZ3	No	intermediary metabolism and respiration			A0A1R3XWZ3				IPR002539	Q7U1K3					Rv0636		Rv0636			
NC_002945.3	Mycobrowser_v4	CDS	734061	734561	.	+	0	Mb0656	hadc		(3r)-hydroxyacyl-acp dehydratase subunit hadc	Mb0656, -, len: 166 aa. Equivalent to Rv0637, len: 166 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 166 aa overlap). Conserved hypothetical protein, equivalent to NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa),FASTA scores: opt: 352, E(): 4e-19, (39.2% identity in 148 aa overlap); and highly similar to others from Mycobacterium leprae e.g. NP_302287.1|NC_002677 conserved hypothetical protein (159 aa). Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa); Rv0635|NP_215149.1|NC_000962|MTY20H10_17 conserved hypothetical protein (two ORFs upstream) from Mycobacterium tuberculosis (158 aa), FASTA score: (49.3% identity in 150 aa overlap); and Rv0504c|NP_215018.1|NC_000962|YV31_MYCTU|Q11168 hypothetical protein from Mycobacterium tuberculosis (166 aa), FASTA scores: opt: 380, E(): 3.8e-21, (43.1% identity in 137 aa overlap).	X2BFQ7,Q7U1K2	No	intermediary metabolism and respiration			Q7U1K2					X2BFQ7					Rv0637		Rv0637			
NC_002945.3	Mycobrowser_v4	CDS	734973	735458	.	+	0	Mb0657	secE1		PROBABLE PREPROTEIN TRANSLOCASE SECE1	Mb0657, secE1, len: 161 aa. Equivalent to Rv0638,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Probable secE1,preprotein translocase (tail-anchored membrane protein),highly similar at C-terminal half to others e.g. P36690|SECE_STRGR PREPROTEIN TRANSLOCASE SECE SUBUNIT from Streptomyces griseus (86 aa), FASTA scores: opt: 220, E(): 4.6e-06, (35.4% identity in 96 aa overlap); P16920|SECE_ECOLI preprotein translocase sece subunit from Escherichia coli strains K12 and O157:H7 (127 aa), FASTA scores: opt: 122, E(): 0.34, (37.0% identity in 54 aa overlap); etc. Contains PS01067 Protein secE/sec61-gamma signature. BELONGS TO THE SECE/SEC61-GAMMA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE, SECF|Rv2586c,SECG|Rv1440 AND SECY|Rv0732. Note that previously known as secE.	X2BFN4,P0A5Z1,P0A5Z1	No				P0A5Z1					X2BFN4,P0A5Z1										
NC_002945.3	Mycobrowser_v4	CDS	735490	736206	.	+	0	Mb0658	nusG		PROBABLE TRANSCRIPTION ANTITERMINATION PROTEIN NUSG	Mb0658, nusG, len: 238 aa. Equivalent to Rv0639,len: 238 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 238 aa overlap). Probable nusG,transcription antitermination protein, equivalent to NP_302283.1|NC_002677 transcription antitermination protein nusG from Mycobacterium leprae (228 aa). Also highly similar to others e.g. P36260|NUSG_STRGR from Streptomyces griseus (294 aa), FASTA scores: opt: 845,E(): 0, (55.4% identity in 233 aa overlap); etc. Note that shorter at the N-terminus than other nusG. Contains PS01014 Transcription termination factor nusG signature. BELONGS TO THE NUSG FAMILY.	X2BFN3,P65590,P65590	No	information pathways			P65590					X2BFN3,P65590					Rv0639		Rv0639			
NC_002945.3	Mycobrowser_v4	CDS	736258	736686	.	+	0	Mb0659	rplK		50s ribosomal protein l11 rplk	Mb0659, rplK, len: 142 aa. Equivalent to Rv0640,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable rplK, 50S ribosomal protein L11, equivalent to NP_302282.1|NC_002677 50S ribosomal protein L11 from Mycobacterium leprae (142 aa). Also highly similar to others e.g. P48954|RL11_STRCO|SCD82.19 50s ribosomal protein L11 from Streptomyces coelicolor (144 aa), FASTA scores: opt: 763,E(): 0, (84.6% identity in 143 aa overlap); etc. Contains PS00359 Ribosomal protein L11 signature. BELONGS TO THE L11P FAMILY OF RIBOSOMAL PROTEINS.	X2BFH0,P66057,P66057	No	information pathways			P66057					X2BFH0,P66057					Rv0640		Rv0640			
NC_002945.3	Mycobrowser_v4	CDS	737534	738439	.	-	0	Mb0661c	mmaA4		METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE)	Mb0661c, mmaA4, len: 301 aa. Equivalent to Rv0642c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 301 aa overlap). mmaA4, methoxy mycolic acid synthase 4 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (298 aa); NP_302280.1|NC_002677 methyl mycolic acid synthase 4 from Mycobacterium leprae (298 aa); and highly similar to others from Mycobacteria e.g. downstream ORF P72027|mmaA3|Rv0643c|MTCY20H10.24c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 3 from Mycobacterium tuberculosis (293 aa).	X2BFR1,Q7U1K1,Q7U1K1	No				Q7U1K1					X2BFR1,Q7U1K1										
NC_002945.3	Mycobrowser_v4	CDS	738504	739385	.	-	0	Mb0662c	mmaA3		METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE)	Mb0662c, mmaA3, len: 293 aa. Equivalent to Rv0643c,len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 293 aa overlap). mmaA3, methoxy mycolic acid synthase 3 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (289 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa).	X2BFP0,Q7U1K0,Q7U1K0	No				Q7U1K0					X2BFP0,Q7U1K0										
NC_002945.3	Mycobrowser_v4	CDS	739533	740396	.	-	0	Mb0663c	mmaA2		METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 (METHYL MYCOLIC ACID SYNTHASE 2) (MMA2) (HYDROXY MYCOLIC ACID SYNTHASE)	Mb0663c, mmaA2, len: 287 aa. Equivalent to Rv0644c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). mmaA2, methoxy mycolic acid synthase 2 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (287 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). Note that alternative start is at position 739247.	X2BFN6,Q7U1J9,Q7U1J9	No				Q7U1J9					X2BFN6,Q7U1J9										
NC_002945.3	Mycobrowser_v4	CDS	740563	741423	.	-	0	Mb0664c	mmaA1		METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE)	Mb0664c, mmaA1, len: 286 aa. Equivalent to Rv0645c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). mmaA1, methoxy mycolic acid synthase 1 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to NP_302279.1|NC_002677 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa).	X2BFH5,P0A5Q1,P0A5Q1	No				P0A5Q1					X2BFH5,P0A5Q1										
NC_002945.3	Mycobrowser_v4	CDS	741470	742375	.	-	0	Mb0665c	lipG		PROBABLE LIPASE/ESTERASE LIPG	Mb0665c, lipG, len: 301 aa. Equivalent to Rv0646c,len: 301 aa. from Mtycobacterium tuberculosis strain H37Rv, (100.0% identity in 301 aa overlap). Probable lipG,lipase/esterase (EC 3.1.-.-), equivalent to NP_302278.1|NC_002677 probable hydrolase from Mycobacterium leprae (304 aa). Also highly similar to various hydrolases, especially lipases e.g. AA61351.1|X88895 carboxyl esterase from Acinetobacter calcoaceticus (312 aa), FASTA scores: opt: 867, E(): 0,(50.2% identity in 279 aa overlap); etc. Also similar to transferases e.g. P77026 MACROLIDE 2'-PHOSPHOTRANSFERASE II from Escherichia coli (279 aa), FASTA scores: E(): 1.3e-14, (32.5% identity in 286 aa overlap). Similar to M. tuberculosis non-heme bromoperoxidases and epoxide hydrolases.	Q7U1J8,A0A1R3XX04	No				A0A1R3XX04					Q7U1J8										
NC_002945.3	Mycobrowser_v4	CDS	748132	748806	.	+	0	Mb0668	fabD2		possible malonyl coa-acyl carrier protein transacylase fabd2 (mct)	Mb0668, fabD2, len: 224 aa. Equivalent to Rv0649,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible fabD2,malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39), similar to MTFABD|FABD_MYCTU|Q10501|Rv2243 malonyl CoA-acyl carrier protein transacylase from Mycobacterium tuberculosis (302 aa), FASTA scores: opt: 133, E(): 0.074, (31.3% identity in 147 aa overlap).	Q7U1J5,A0A1R3XVZ5	No				A0A1R3XVZ5				IPR027304	Q7U1J5										
NC_002945.3	Mycobrowser_v4	CDS	750045	750581	.	+	0	Mb0670	rplJ		50s ribosomal protein l10 rplj	Mb0670, rplJ, len: 178 aa. Equivalent to Rv0651,len: 178 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 178 aa overlap). Probable rplJ, 50S ribosomal protein L10, equivalent to NP_302276.1|NC_002677 50S ribosomal protein L10 from Mycobacterium leprae (177 aa). Also highly similar to others e.g. P36257|RL10_STRGR 50s ribosomal protein L10 from Streptomyces griseus (185 aa), FASTA scores: opt: 633, E(): 0, (59.0 % identity in 173 aa overlap); etc. BELONGS TO THE L10P FAMILY OF RIBOSOMAL PROTEINS.	X2BFP4,P66045,P66045	No	information pathways			P66045					X2BFP4,P66045					Rv0651		Rv0651			
NC_002945.3	Mycobrowser_v4	CDS	750618	751010	.	+	0	Mb0671	rplL		50s ribosomal protein l7/l12 rpll (sa1)	Mb0671, rplL, len: 130 aa. Equivalent to Rv0652,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Probable rplL (alternate gene name: L7|L12), 50S ribosomal protein L7/L12, equivalent to NP_302275.1|NC_002677 50S ribosomal protein L7/L12 from Mycobacterium leprae (130 aa); and P37381|RL7_MYCBO 50s ribosomal protein L7/L12 from Mycobacterium bovis (130 aa). Also highly similar to others e.g. P02396|RL7_STRGR 50S RIBOSOMAL PROTEIN L7/L12 from Streptomyces griseus (127 aa); etc. BELONGS TO THE L12P FAMILY OF RIBOSOMAL PROTEINS.	X2BFS4,P0A5V3,P0A5V3	No	information pathways			P0A5V3					X2BFS4,P0A5V3					Rv0652		Rv0652			
NC_002945.3	Mycobrowser_v4	CDS	753286	754365	.	+	0	Mb0674	mkl		POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL	Mb0674, mkl, len: 359 aa. Equivalent to Rv0655,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Possible mkl,ribonucleotide-transport ATP-binding protein ABC transporter (see first citation below), equivalent to P30769|MKL_MYCLE|ML1892 POSSIBLE RIBONUCLEOTIDE TRANSPORT ATP-BINDING PROTEIN from Mycobacterium leprae (347 aa),FASTA scores: opt: 2021, E(): 0, (92.2% identity in 335 aa overlap). Also highly similar to many e.g. AB92896.1|AL356992 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (343 aa); NP_253146.1|NC_002516 probable ATP-binding component of ABC transporter from Pseudomonas aeruginosa (269 aa); P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding protein from Escherichia coli (269 aa), FASTA scores: opt: 644, E(): 3.4e-33, (38.5% identity in 244 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351 aa), FASTA score: (33.6% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	X2BFI5,P63358,P63358	No	cell wall and cell processes			P63358					X2BFI5,P63358					Rv0655		Rv0655			
NC_002945.3	Mycobrowser_v4	CDS	755231	755386	.	-	0	Mb0676c	vapb6		possible antitoxin vapb6	Mb0676c, -, len: 51 aa. Equivalent to Rv0657c, len: 51 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 51 aa overlap). Conserved hypothetical protein, showing similarity with hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa),FASTA scores: opt: 107, E(): 0.0038, (45.8% identity in 48 aa overlap), Rv2871, Rv1560, etc. Also some similarity with AL020958|SC4H8_7 from Streptomyces coelicolor (66 aa), FASTA score: (41.0% identity in 39 aa overlap).	Q7U1J0,A0A1R3XW48	No	virulence, detoxification, adaptation			A0A1R3XW48				IPR019239	Q7U1J0					Rv0657c		Rv0657c			
NC_002945.3	Mycobrowser_v4	CDS	756454	756762	.	-	0	Mb0678c	mazf2		toxin mazf2	Mb0678c, -, len: 102 aa. Equivalent to Rv0659c,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Conserved hypothetical protein, weakly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1942c, Rv1495, etc.	Q7U1I8,A0A1R3XW06	No	virulence, detoxification, adaptation			A0A1R3XW06				IPR003477,IPR011067	Q7U1I8					Rv0659c		Rv0659c			
NC_002945.3	Mycobrowser_v4	CDS	756749	756994	.	-	0	Mb0679c	maze2		possible antitoxin maze2	Mb0679c, -, len: 81 aa. Equivalent to Rv0660c, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing some similarity to AF016485_130 from Halobacterium sp (100 aa), FASTA scores: (32.4% identity in 74 aa overlap).	Q7U1I7,A0A1R3XW41	No	virulence, detoxification, adaptation			A0A1R3XW41					Q7U1I7					Rv0660c		Rv0660c			
NC_002945.3	Mycobrowser_v4	CDS	757906	760269	.	+	0	Mb0682	atsD		POSSIBLE ARYLSULFATASE ATSD (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE)	Mb0682, atsD, len: 787 aa. Equivalent to Rv0663,len: 787 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 787 aa overlap). Possible atsD,arylsulfatase (EC 3.1.6.1), similar to others e.g. P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% identity in 544 aa overlap); etc. Also similar to P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from Mycobacterium tuberculosis (787 aa), FASTA score: (38.9% identity in 769 aa overlap); and other arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa),Rv0711, etc. Contains PS00523 Sulfatases signature 1. BELONGS TO THE SULFATASE FAMILY.	Q7U1I4,A0A1R3XW05	No	intermediary metabolism and respiration			A0A1R3XW05				IPR000917,IPR008985,IPR013320,IPR017849,IPR017850,IPR024607	Q7U1I4					Rv0663		Rv0663			
NC_002945.3	Mycobrowser_v4	CDS	761576	765094	.	+	0	Mb0686	rpoB		DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT)	Mb0686, rpoB, len: 1172 aa. Equivalent to Rv0667,len: 1172 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1172 aa overlap). rpoB,DNA-directed RNA polymerase, beta chain (EC 2.7.7.6) (see first and third citations below), equivalent to P30760|RPOB_MYCLE|ML1891 DNA-directed RNA polymerase beta chain from Mycobacterium leprae (1178 aa). Also highly similar to others e.g. AAF60349.1|AF242549_1|AF242549 DNA-dependent RNA polymerase beta subunit from Amycolatopsis mediterranei (1167 aa); CAB77428.1|AL160431 DNA-directed RNA polymerase beta chain from Streptomyces coelicolor (1161 aa); etc. Start site chosen on basis of RBS but alternative start exists at position 14359. BELONGS TO THE RNA POLYMERASE BETA CHAIN FAMILY.	X2BFU0,P0A681,P0A681	No				P0A681					X2BFU0,P0A681										
NC_002945.3	Mycobrowser_v4	CDS	765139	769089	.	+	0	Mb0687	rpoC		DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT).	Mb0687, rpoC, len: 1316 aa. Equivalent to Rv0668,len: 1316 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1316 aa overlap). rpoC,DNA-directed RNA polymerase, beta' chain (EC 2.7.7.6) (see first citation below), equivalent to P30761|RPOC_MYCLE|ML1890|S31146 DNA-directed RNA polymerase (EC 2.7.7.6) beta' chain from Mycobacterium leprae (1316 aa), FASTA scores: opt: 8295, E(): 0, (95.6% identity in 1316 aa overlap). Also highly similar to others e.g. CAB77429.1|AL160431 DNA-directed RNA polymerase beta' chain (fragment) from Streptomyces coelicolor (1059 aa); P37871|RPOC_BACSU from Bacillus subtilis (1199 aa), FASTA scores: opt: 2367, E(): 0, (52.9 identity in 1317 aa overlap); etc. BELONGS TO THE RNA POLYMERASE BETA' CHAIN FAMILY.	X2BFS1,P0A675,P0A675	No				P0A675					X2BFS1,P0A675										
NC_002945.3	Mycobrowser_v4	CDS	771561	772319	.	+	0	Mb0689	end		PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	Mb0689, end, len: 252 aa. Equivalent to Rv0670,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable end (alternate gene name: nfo), endonuclease IV (apurinase) (EC 3.1.21.2), equivalent to END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV (apurinase) from Mycobacterium leprae (252 aa), FASTA scores: opt: 1463, E(): 0, (85.6% identity in 250 aa overlap). Also similar to others e.g. Q9S2N2|END4_STRCO|NFO|SC6E10.05 PROBABLE ENDONUCLEASE IV from Streptomyces coelicolor (294 aa); etc. Contains PS00729 AP endonucleases family 2 signatures 1 and 2 (PS00729, and PS00730). BELONGS TO THE AP ENDONUCLEASES FAMILY 2. COFACTOR: BINDS 3 ZINC IONS.	X2BFK7,P63536,P63536	No	information pathways			P63536					X2BFK7,P63536					Rv0670		Rv0670			
NC_002945.3	Mycobrowser_v4	CDS	772351	773193	.	+	0	Mb0690	lpqP		POSSIBLE CONSERVED LIPOPROTEIN LPQP	Mb0690, lpqP, len: 280 aa. Equivalent to Rv0671,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Possible lpqP,conserved lipoprotein, similar to U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302 aa), FASTA scores: opt: 449, E(): 2.4e-22, (37.6% identity in 242 aa overlap). Also highly similar to lpqC|Rv3298c|MTCY71.38c PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (304 aa). Also similar to a large variety of proteins including various esterases and poly(3-hydroxyalkanoate) depolymerases, e.g. NP_249234.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (322 aa); C-terminus of AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase EstA from Piromyces equi (536 aa); part of P52090|PHA1_PSELE POLY(3-HYDROXYALKANOATE) DEPOLYMERASE C PRECURSOR from Pseudomonas lemoignei (414 aa); CAC10310.1|AL442629 putative secreted protein from Streptomyces coelicolor (348 aa); etc. Has a 17 aa signal sequence and contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site.	Q7U1H9,A0A1R3XW27	No	cell wall and cell processes			A0A1R3XW27					Q7U1H9					Rv0671		Rv0671			
NC_002945.3	Mycobrowser_v4	CDS	773253	774881	.	+	0	Mb0691	fadE8		PROBABLE ACYL-COA DEHYDROGENASE FADE8	Mb0691, fadE8, len: 542 aa. Equivalent to Rv0672,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 542 aa overlap). Probable fadE8,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAC33951.1|AL589708 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (557 aa); P33224|AIDB_ECOLI|B4187 aidb protein (ACYL-COA DEHYDROGENASES FAMILY) from Escherichia coli strain K12 (546 aa), FASTA scores: opt: 1369, E(): 0, (44.1% identity in 524 aa overlap); etc. Also similar to several other M. tuberculosis proteins e.g. Rv0154cRv0154c|MTCI5.28c FASTA score: (26.3% identity in 342 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073). BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7U1H8,A0A1R3XW22	No				A0A1R3XW22				IPR006089,IPR006091,IPR009075,IPR009100	Q7U1H8										
NC_002945.3	Mycobrowser_v4	CDS	774892	775830	.	+	0	Mb0692	echA4		POSSIBLE ENOYL-COA HYDRATASE ECHA4 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb0692, echA4, len: 312 aa. Equivalent to Rv0673,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 312 aa overlap). Possible echA4,enoyl-CoA hydratase (EC 4.2.1.17), showing similarity with others e.g. NP_419216.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (256 aa); Q52995|ECHH_RHIME PROBABLE ENOYL-COA HYDRATASE from Sinorhizobium meliloti (257 aa), FASTA scores: opt: 210, E(): 1.2e-06, (27.9% identity in 280 aa overlap); etc. Also similar to other enoyl-CoA hydratases from Mycobacterium tuberculosis e.g. P95279|MTCY09F9.29|ECHA13|Rv1935c|MTCY09F9.29 ENOYL-COA HYDRATASE (318 aa), FASTA score: (27.1% identity in 280 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U1H7,A0A1R3XW17	No				A0A1R3XW17				IPR001753	Q7U1H7										
NC_002945.3	Mycobrowser_v4	CDS	776552	777343	.	+	0	Mb0694	echA5		PROBABLE ENOYL-COA HYDRATASE ECHA5 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb0694, echA5, len: 263 aa. Equivalent to Rv0675,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 263 aa overlap). Probable echA5,enoyl-CoA hydratase (EC 4.2.1.17), similar to several e.g. NP_252116.1|NC_002516 probable enoyl CoA-hydratase/isomerase from Pseudomonas aeruginosa (256 aa); Q20376 PROTEIN SIMILAR TO ENOYL-COA HYDRATASE from Caenorhabditis elegans (258 aa), FASTA scores: opt: 697,E(): 0, (47.3% identity in 245 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Z92669|MTCY8D5_17 (262 aa), FASTA scores: opt: 493, E(): 3.6e-25, (39.1% identity in 243 aa overlap); etc.	Q7U1H5,A0A1R3XY72	No				A0A1R3XY72				IPR001753,IPR018376	Q7U1H5										
NC_002945.3	Mycobrowser_v4	CDS	783703	784173	.	+	0	Mb0702	rpsG		30s ribosomal protein s7 rpsg	Mb0702, rpsG, len: 156 aa. Equivalent to Rv0683,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 156 aa overlap). Probable rpsG, 30S ribosomal protein S7 (see citation below), equivalent to others from Mycobacteria e.g. P41193|RS7_MYCSM 30S RIBOSOMAL PROTEIN S7 from Mycobacterium smegmatis (156 aa), FASTA scores: opt: 986, E(): 0, (96.2% identity in 156 aa overlap); Q53539|RS7_MYCBO 30S RIBOSOMAL PROTEIN S7 from Mycobacterium bovis (156 aa); etc. Also highly similar to others e.g. Q9L0K4|RS7_STRCO 30S RIBOSOMAL PROTEIN S7 from Streptomyces coelicolor (156 aa); etc. Contains PS00052 Ribosomal protein S7 signature. BELONGS TO THE S7P FAMILY OF RIBOSOMAL PROTEINS.	X2BFT8,Q53539,Q53539	No	information pathways			Q53539					X2BFT8,Q53539					Rv0683		Rv0683			
NC_002945.3	Mycobrowser_v4	CDS	777355	780249	.	-	0	Mb0695c	mmpL5		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL5	Mb0695c, mmpL5, len: 964 aa. Equivalent to Rv0676c,len: 964 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 964 aa overlap). Probable mmpL5,conserved transmembrane transport protein (see first citation below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. MTV037_14, MTCY98_8,MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19,etc. Also similar to other Mycobacterial mmpl proteins e.g. P54881|MML4_MYCLE PUTATIVE MEMBRANE PROTEIN MMPL4 from Mycobacterium leprae (959 aa), FASTA scores: opt: 3991, E(): 0, (62.8% identity in 933 aa overlap); etc. BELONGS TO THE MMPL FAMILY. TBparse score is 0.884.	Q7U1H4,A0A1R3XX34	No				A0A1R3XX34				IPR004707,IPR004869	Q7U1H4										
NC_002945.3	Mycobrowser_v4	CDS	783329	783703	.	+	0	Mb0701	rpsL		30s ribosomal protein s12 rpsl	Mb0701, rpsL, len: 124 aa. Equivalent to Rv0682,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Probable rpsL, 30S ribosomal protein S12 (see citations below), equivalent to others from Mycobacteria e.g. P41195|RS12_MYCSM 30S RIBOSOMAL PROTEIN S12 from Mycobacterium smegmatis (124 aa); P51999|RS12_MYCAV 30S RIBOSOMAL PROTEIN S12 from Mycobacterium avium (124 aa); etc. Also highly similar to others from other organisms e.g. P97222|RS12_STRCO 30S RIBOSOMAL PROTEIN S12 from Streptomyces roseosporus,lividans and coelicolor (123 aa); etc. Contains PS00055 Ribosomal protein S12 signature. BELONGS TO THE S12P FAMILY OF RIBOSOMAL PROTEINS.	X2BFV8,Q53538,Q53538	No	information pathways			Q53538					X2BFV8,Q53538					Rv0682		Rv0682			
NC_002945.3	Mycobrowser_v4	CDS	784254	786359	.	+	0	Mb0703	fusA1		PROBABLE ELONGATION FACTOR G FUSA1 (EF-G)	Mb0703, fusA1, len: 701 aa. Equivalent to Rv0684,len: 701 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 701 aa overlap). Probable fusA1,elongation factor G, equivalent to P30767|EFG_MYCLE|S31150 translation elongation factor EF-G from Mycobacterium leprae (701 aa), FASTA scores: opt: 2521, E(): 0, (88.2% identity in 432 aa overlap). Also highly similar to others e.g. CAB81852.1|AL161691 elongation factor G from Streptomyces coelicolor (708 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. Note that previously known as fusA.	X2BFQ9,P0A557,P0A557	No				P0A557					X2BFQ9,P0A557										
NC_002945.3	Mycobrowser_v4	CDS	786590	787780	.	+	0	Mb0704	tuf		probable iron-regulated elongation factor tu tuf (ef-tu)	Mb0704, tuf, len: 396 aa. Equivalent to Rv0685,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Probable tuf,elongation factor EF-Tu, equivalent to JC2262 translation elongation factor Tu from Mycobacterium leprae (396 aa). Also highly similar to others e.g. P42439|EFTU_CORGL ELONGATION FACTOR TU (EF-TU) from Corynebacterium glutamicum (396 aa); etc. Contains PS00017 ATP/GTP-binding site motif A, and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, EF-TU/EF-1A SUBFAMILY.	X2BFM6,P0A559,P0A559	No	information pathways			P0A559					X2BFM6,P0A559					Rv0685		Rv0685			
NC_002945.3	Mycobrowser_v4	CDS	793926	795101	.	+	0	Mb0712	pqqE		PROBABLE COENZYME PQQ SYNTHESIS PROTEIN E PQQE (COENZYME PQQ SYNTHESIS PROTEIN III)	Mb0712, pqqE, len: 391 aa. Equivalent to Rv0693,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 391 aa overlap). Probable pqqE (alternate gene name: pqqIII), coenzyme PQQ synthesis protein E, similar to others AE001109_9|O30258|PQQE COENZYME PQQ SYNTHESIS PROTEIN from Archaeoglobus fulgidus (375 aa), FASTA scores: E(): 1.6e-16, (28.1% identity in 377 aa overlap); PQQE_ACICA|P07782 coenzyme pqq synthesis protein e from Acinetobacter calcoaceticus (384 aa), FASTA scores: opt: 302, E(): 1.8e-12, (23.9% identity in 377 aa overlap); etc. Also similar to C-terminus of heme biosynthesis proteins e.g. O28270|AF2009 HEME BIOSYNTHESIS PROTEIN (NIRJ-2) from Archaeoglobus fulgidus (468 aa). Note that also highly similar to U17129|RSU17129_4|AAC77478.1 unknown protein from Rhodococcus erythropolis (405 aa), FASTA scores: opt: 1997, E(): 0, (73.3% identity in 390 aa overlap). COULD BELONG TO THE MOAA / NIFB / PQQE FAMILY.	Q7U1G2,A0A1R3XW47	No	intermediary metabolism and respiration			A0A1R3XW47				IPR006638,IPR007197,IPR013785,IPR017200,IPR023885,IPR023913	Q7U1G2					Rv0693		Rv0693			
NC_002945.3	Mycobrowser_v4	CDS	795104	796294	.	+	0	Mb0713	lldD1		POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD1	Mb0713, lldD1, len: 396 aa. Equivalent to Rv0694,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). Possible lldD1,L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar to NP_302368.1|NC_002677 L-lactate dehydrogenase from Mycobacterium leprae (414 aa). Also similar to others e.g. NP_384560.1|NC_003047 PUTATIVE L-LACTATE DEHYDROGENASE (CYTOCHROME) PROTEIN from Sinorhizobium meliloti (403 aa); NP_251072.1|NC_002516 L-lactate dehydrogenase from Pseudomonas aeruginosa (383 aa); P33232|LLDD_ECOLI L-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa), FASTA scores: opt: 697, E(): 0, (34.5 identity in 380 aa overlap); etc; and also similar to other oxidoreductases. Note that also highly similar to RSU17129_5|AAC77479.1|U17129 unknown protein from Rhodococcus erythropolis (392 aa), FASTA scores: opt: 2006, E(): 0, (74.1% identity in 386 aa overlap). Also similar to lldD2|Rv1872c|MTCY180.46|MTCY359.01 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis (414 aa). BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY.	Q7U1G1,A0A1R3XY91	No				A0A1R3XY91				IPR000262,IPR012133,IPR013785,IPR023989	Q7U1G1										
NC_002945.3	Mycobrowser_v4	CDS	808157	808603	.	+	0	Mb0731	atsAa		POSSIBLE ARYLSULFATASE ATSAa [FIRST PART] (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE)	Mb0731, atsAa, len: 148 aa. Equivalent to 5' end of Rv0711, len: 787 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 148 aa overlap). Possible atsA, arylsulfatase (EC 3.1.6.1), similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439,E(): 2.9e-21, (30.8% identity in 552 aa overlap); etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases signature 1, and PS00149 Sulfatases signature 2. BELONGS TO THE SULFATASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t),introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb.	Q7U1F3,A0A1R3XW61	No				A0A1R3XW61				IPR000917,IPR017849,IPR017850,IPR024607	Q7U1F3										
NC_002945.3	Mycobrowser_v4	CDS	802255	802560	.	+	0	Mb0720	rpsJ		30S RIBOSOMAL PROTEIN S10 RPSJ (TRANSCRIPTION ANTITERMINATION FACTOR NUSE)	Mb0720, rpsJ, len: 101 aa. Equivalent to Rv0700,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). rpsJ (alternate gene name: nusE), 30S ribosomal protein S10 (see first citation below), equivalent to RS10_MYCLE P307653 30S ribosomal protein S10 from Mycobacterium leprae (101 aa), FASTA scores: opt: 645, E(): 0, (97.0% identity in 101 aa overlap). Also highly similar to others e.g. CAB82069.1|AL161803 30S ribosomal protein S10 from Streptomyces coelicolor (102 aa); etc. Contains PS00361 Ribosomal protein S10 signature. BELONGS TO THE S10P FAMILY OF RIBOSOMAL PROTEINS.	X2BFX5,P0A5X1,P0A5X1	No	information pathways			P0A5X1					X2BFX5,P0A5X1					Rv0700		Rv0700			
NC_002945.3	Mycobrowser_v4	CDS	802577	803230	.	+	0	Mb0721	rplC		50s ribosomal protein l3 rplc	Mb0721, rplC, len: 217 aa. Equivalent to Rv0701,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Probable rplC, 50S ribosomal protein L3, equivalent to O06044|RL3_MYCBO 50S RIBOSOMAL PROTEIN L3 from Mycobacterium bovis BCG (217 aa); and P30762|RL3_MYCLE 50S RIBOSOMAL PROTEIN L3 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. CAB82070.1|AL161803 50S ribosomal protein L3 from Streptomyces coelicolor (214 aa); P52860|RL3_THETH ribosomal protein l3 from Thermus aquaticus (206 aa),FASTA scores: opt: 717, E(): 0, (55.2% identity in 210 aa overlap); etc. Contains PS00474 Ribosomal protein L3 signature. BELONGS TO THE L3P FAMILY OF RIBOSOMAL PROTEINS.	X2BFW2,P60441,P60441	No	information pathways			P60441					X2BFW2,P60441					Rv0701		Rv0701			
NC_002945.3	Mycobrowser_v4	CDS	803230	803901	.	+	0	Mb0722	rplD		50s ribosomal protein l4 rpld	Mb0722, rplD, len: 223 aa. Equivalent to Rv0702,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 223 aa overlap). Probable rplD, 50S ribosomal protein L4, equivalent to O06045|RL4_MYCBO 50S RIBOSOMAL PROTEIN L4 from Mycobacterium bovis BCG (223 aa); O06114|RL4_MYCSM 50S RIBOSOMAL PROTEIN L4 from Mycobacterium smegmatis (215 aa); and MLCB2492_3 50S ribosomal protein L4 from Mycobacterium leprae (230 aa). Also highly similar to others e.g. CAB82071.1|AL161803 50S ribosomal protein L4 from Streptomyces coelicolor (219 aa); P28601|RL4_BACST 50s ribosomal protein L4 from Bacillus stearothermophilus (207 aa), FASTA scores: opt: 522, E(): 3.5e-26, (42.4% identity in 198 aa overlap); etc. BELONGS TO THE L4P FAMILY OF RIBOSOMAL PROTEINS.	X2BFS0,P60728,P60728	No	information pathways			P60728					X2BFS0,P60728					Rv0702		Rv0702			
NC_002945.3	Mycobrowser_v4	CDS	803901	804203	.	+	0	Mb0723	rplW		50s ribosomal protein l23 rplw	Mb0723, rplW, len: 100 aa. Equivalent to Rv0703,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). Probable rplW, 50S ribosomal protein L23, equivalent to O06046|RL23_MYCBO 50S RIBOSOMAL PROTEIN L23 from Mycobacterium bovis BCG (100 aa); and MLCB2492_4 50S RIBOSOMAL PROTEIN L23 from Mycobacterium leprae (100 aa). Also highly similar to others e.g. CAB82072.1|AL161803 50S ribosomal protein L23 from Streptomyces coelicolor (139 aa) (N-terminus longer); P04454|RL23_BACST 50s ribosomal protein L23 from Bacillus stearothermophilus (95 aa), FASTA scores: opt: 275, E(): 1.4e-13, (50.5% identity in 95 aa overlap); etc. Contains PS00050 Ribosomal protein L23 signature. BELONGS TO THE L23P FAMILY OF RIBOSOMAL PROTEINS.	X2BFQ3,O06046,O06046	No	information pathways			O06046					X2BFQ3,O06046					Rv0703		Rv0703			
NC_002945.3	Mycobrowser_v4	CDS	814449	814634	.	+	0	Mb0738	rpsN1		30s ribosomal protein s14 rpsn1	Mb0738, rpsN1, len: 61 aa. Equivalent to Rv0717,len: 61 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 61 aa overlap). Probable rpsN1, 30S ribosomal protein S14, equivalent to MLCB2492_17|O32996 RIBOSOMAL PROTEIN S14 from Mycobacterium leprae (61 aa). Also highly similar to others e.g. CAB82083.1|AL161803 30S ribosomal protein S14 from Streptomyces coelicolor (61 aa); P24320|RS14_THETH 30s ribosomal protein S14 from Thermus aquaticus (subsp. thermophilus) (60 aa), FASTA scores: opt: 316, E(): 2e-19,(70.0% identity in 60 aa overlap); etc. Contains PS00527 Ribosomal protein S14 signature. BELONGS TO THE S14P FAMILY OF RIBOSOMAL PROTEINS. Note that previously known as rpsN.	X2BFS2,P0A5X3,P0A5X3	No	information pathways			P0A5X3					X2BFS2,P0A5X3					Rv0717		Rv0717			
NC_002945.3	Mycobrowser_v4	CDS	804350	805192	.	+	0	Mb0724	rplB		50s ribosomal protein l2 rplb	Mb0724, rplB, len: 280 aa. Equivalent to Rv0704,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable rplB, 50S ribosomal protein L2, equivalent to O06047|RL2_MYCBO 50S RIBOSOMAL PROTEIN L2 from Mycobacterium bovis BCG (280 aa); and MLCB2492_5M 50S RIBOSOMAL PROTEIN L2 from Mycobacterium leprae (280 aa). Also highly similar to others e.g. CAB82073.1|AL161803 50S ribosomal protein L2 from Streptomyces coelicolor (278 aa); P42919|RL2_BACSU 50s ribosomal protein l2 (bl2) from Bacillus subtilis (276 aa), FASTA scores: opt: 1179, E(): 0, (61.1% identity in 275 aa overlap); etc. Contains PS00467 Ribosomal protein L2 signature. BELONGS TO THE L2P FAMILY OF RIBOSOMAL PROTEINS.	X2BFW0,O06047,O06047	No	information pathways			O06047					X2BFW0,O06047					Rv0704		Rv0704			
NC_002945.3	Mycobrowser_v4	CDS	805233	805514	.	+	0	Mb0725	rpsS		30s ribosomal protein s19 rpss	Mb0725, rpsS, len: 93 aa. Equivalent to Rv0705,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable rpsS, 30S ribosomal protein S19, equivalent to S36895 ribosomal protein S19 from Mycobacterium bovis (93 aa), FASTA scores: opt: 623, E(): 0, (98.9% identity in 93 aa overlap); and NP_302261.1|NC_002677 30S ribosomal protein S19 from Mycobacterium leprae (93 aa). Also highly similar to others e.g. CAB82074.1|AL161803 30S ribosomal protein S19 from Streptomyces coelicolor (93 aa); etc. Contains PS00323 Ribosomal protein S19 signature. BELONGS TO THE S19P FAMILY OF RIBOSOMAL PROTEINS.	X2BFY0,P0A5X5,P0A5X5	No	information pathways			P0A5X5					X2BFY0,P0A5X5					Rv0705		Rv0705			
NC_002945.3	Mycobrowser_v4	CDS	806104	806928	.	+	0	Mb0727	rpsC		30s ribosomal protein s3 rpsc	Mb0727, rpsC, len: 274 aa. Equivalent to Rv0707,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Probable rpsC, 30S ribosomal protein S3, equivalent to O06048|RS3_MYCBO|MBS10OPER_8 30S RIBOSOMAL PROTEIN S3 from Mycobacterium bovis BCG (274 aa); and MLCB2492_8 30S RIBOSOMAL PROTEIN S3 from Mycobacterium leprae (281 aa). Also highly similar to others e.g. CAB82076.1|AL161803 30S ribosomal protein S3 from Streptomyces coelicolor (277 aa); P21465|RS3_BACSU 30s ribosomal protein s3 (bs3) (bs2) from Bacillus subtilis (217 aa), FASTA scores: opt: 794,E(): 0, (52.8% identity in 212 aa overlap); etc. BELONGS TO THE S3P FAMILY OF RIBOSOMAL PROTEINS.	X2BFS3,P0A5X7,P0A5X7	No	information pathways			P0A5X7					X2BFS3,P0A5X7					Rv0707		Rv0707			
NC_002945.3	Mycobrowser_v4	CDS	806932	807348	.	+	0	Mb0728	rplP		50s ribosomal protein l16 rplp	Mb0728, rplP, len: 138 aa. Equivalent to Rv0708,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Probable rplP, 50S ribosomal protein L16, equivalent to O06049|RL16_MYCBO|MBS10OPER_9 50S RIBOSOMAL PROTEIN L16 from Mycobacterium bovis BCG (138 aa); and MLCB2492_9 50S RIBOSOMAL PROTEIN L16 from Mycobacterium leprae (138 aa). Also highly similar to others e.g. CAB82077.1|AL161803 50S ribosomal protein L16 from Streptomyces coelicolor (139 aa); P14577|RL16_BACSU 50s ribosomal protein l16 from Bacillus subtilis (144 aa), FASTA scores: opt: 600, E(): 0, (63.2% identity in 136 aa overlap); etc. Contains PS00701 Ribosomal protein L16 signature 2. BELONGS TO THE L16P FAMILY OF RIBOSOMAL PROTEINS.	X2BFR0,O06049,O06049	No	information pathways			O06049					X2BFR0,O06049					Rv0708		Rv0708			
NC_002945.3	Mycobrowser_v4	CDS	807348	807581	.	+	0	Mb0729	rpmC		50s ribosomal protein l29 rpmc	Mb0729, rpmC, len: 77 aa. Equivalent to Rv0709,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Probable rpmC, 50S ribosomal protein L29, equivalent to O06050|RL29_MYCBO|MBS10OPER_10 50S RIBOSOMAL PROTEIN L29 from Mycobacterium bovis BCG (75 aa); and O32989|RL29_MYCLE|MLCB2492_10 50S RIBOSOMAL PROTEIN L29 from Mycobacterium leprae (80 aa). Also highly similar to others e.g. Q9L0D2|RL29_STRCO 50S RIBOSOMAL PROTEIN L29 from Streptomyces coelicolor (74 aa); P12873|RL29_BACSU 50s ribosomal protein l29 from Bacillus subtilis (66 aa),FASTA scores: opt: 225, E(): 8.3e-11, (58.6% identity in 58 aa overlap); etc. BELONGS TO THE L29P FAMILY OF RIBOSOMAL PROTEINS.	X2BFW6,O06050,O06050	No	information pathways			O06050					X2BFW6,O06050					Rv0709		Rv0709			
NC_002945.3	Mycobrowser_v4	CDS	807578	807988	.	+	0	Mb0730	rpsQ		30s ribosomal protein s17 rpsq	Mb0730, rpsQ, len: 136 aa. Equivalent to Rv0710,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Probable rpsQ, 30S ribosomal protein S17, equivalent to O06051|RS17_MYCBO 30S|MBS10OPER_11 30S RIBOSOMAL PROTEIN S17 from Mycobacterium bovis BCG (136 aa); and MLCB2492_11 30S RIBOSOMAL PROTEIN S17 from Mycobacterium leprae (126 aa). Also highly similar to others e.g. CAB82079.1|AL161803 30S ribosomal protein S17 from Streptomyces coelicolor (95 aa); P12874|RS17_BACSU 30s ribosomal protein s17 (bs 16) from Bacillus subtilis (86 aa), FASTA scores: opt: 305,E(): 1.6e-11, (60.5% identity in 81 aa overlap); etc. Contains PS00056 Ribosomal protein S17 signature. BELONGS TO THE S17P FAMILY OF RIBOSOMAL PROTEINS.	X2BFY6,O06051,O06051	No	information pathways			O06051					X2BFY6,O06051					Rv0710		Rv0710			
NC_002945.3	Mycobrowser_v4	CDS	808610	810520	.	+	0	Mb0732	atsAb		POSSIBLE ARYLSULFATASE ATSAb [SECOND PART] (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE)	Mb0732, atsAb, len: 636 aa. Equivalent to 3' end of Rv0711, len: 787 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 636 aa overlap). Possible atsA, arylsulfatase (EC 3.1.6.1), similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439,E(): 2.9e-21, (30.8% identity in 552 aa overlap); etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases signature 1, and PS00149 Sulfatases signature 2. BELONGS TO THE SULFATASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t),introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb.	Q7U1F2,A0A1R3XW65	No				A0A1R3XW65				IPR000917,IPR017849,IPR017850	Q7U1F2										
NC_002945.3	Mycobrowser_v4	CDS	813195	813563	.	+	0	Mb0735	rplN		50s ribosomal protein l14 rpln	Mb0735, rplN, len: 122 aa. Equivalent to Rv0714,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable rplN, 50S ribosomal protein L14, equivalent to O32993|MLCB2492_14|ML1849|RL14_MYCLE 50S RIBOSOMAL PROTEIN L14 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82080.1|AL161803 50S ribosomal protein L14 from Streptomyces coelicolor (122 aa); P33100|RL14_MICLU 50s ribosomal protein L14 from Micrococcus luteus (122 aa), FASTA scores: opt: 674, E(): 0, (85.2% identity in 122 aa overlap); etc. Contains PS00049 Ribosomal protein L14 signature. BELONGS TO THE L14P FAMILY OF RIBOSOMAL PROTEINS.	X2BFZ2,P66070,P66070	No	information pathways			P66070					X2BFZ2,P66070					Rv0714		Rv0714			
NC_002945.3	Mycobrowser_v4	CDS	815762	816130	.	+	0	Mb0741	rplR		50s ribosomal protein l18 rplr	Mb0741, rplR, len: 122 aa. Equivalent to Rv0720,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Probable rplR, 50S ribosomal protein L18, equivalent to O32999|MLCB2492_20|RL18_MYCLE 50S RIBOSOMAL PROTEIN L18 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82086.1|AL161803 50S ribosomal protein L18 from Streptomyces coelicolor (127 aa); P33102|RL18_MICLU 50s ribosomal protein L18 from Micrococcus luteus (119 aa), FASTA scores: opt: 447, E(): 8.7e-24, (60.4% identity in 111 aa overlap); etc. BELONGS TO THE L18P FAMILY OF RIBOSOMAL PROTEINS.	X2BFY4,P66077,P66077	No	information pathways			P66077					X2BFY4,P66077					Rv0720		Rv0720			
NC_002945.3	Mycobrowser_v4	CDS	813564	813881	.	+	0	Mb0736	rplX		50s ribosomal protein l24 rplx	Mb0736, rplX, len: 105 aa. Equivalent to Rv0715,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Probable rplX, 50S ribosomal protein L24, equivalent to O32994|MLCB2492_15 50S RIBOSOMAL PROTEIN L24 from Mycobacterium leprae (105 aa). Also highly similar to others e.g. CAB82081.1|AL161803 50S ribosomal protein L24 from Streptomyces coelicolor (107 aa); P12876|RL24_BACSU 50s ribosomal protein L24 (bl23) from Bacillus subtilis (103 aa), FASTA scores: opt: 363, E(): 1.8e-18, (56.7% identity in 104 aa overlap); etc. Contains PS01108 Ribosomal protein L24 signature. BELONGS TO THE L24P FAMILY OF RIBOSOMAL PROTEINS.	X2BFX8,P60628,P60628	No	information pathways			P60628					X2BFX8,P60628					Rv0715		Rv0715			
NC_002945.3	Mycobrowser_v4	CDS	813881	814444	.	+	0	Mb0737	rplE		50s ribosomal protein l5 rple	Mb0737, rplE, len: 187 aa. Equivalent to Rv0716,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable rplE, 50S ribosomal protein L5, equivalent to MLCB2492_16 50S RIBOSOMAL PROTEIN L5 from Mycobacterium leprae (187 aa). Also highly similar to others e.g. CAB82082.1|AL161803 50S ribosomal protein L5 from Streptomyces coelicolor (185 aa); P33098|RL5_MICLU 50S RIBOSOMAL PROTEIN L5 from Micrococcus luteus (191 aa), FASTA scores: opt: 930, E(): 0, (73.8% identity in 183 aa overlap); etc. BELONGS TO THE L5P FAMILY OF RIBOSOMAL PROTEINS.	X2BFT0,P62402,P62402	No	information pathways			P62402					X2BFT0,P62402					Rv0716		Rv0716			
NC_002945.3	Mycobrowser_v4	CDS	814798	815196	.	+	0	Mb0739	rpsH		30s ribosomal protein s8 rpsh	Mb0739, rpsH, len: 132 aa. Equivalent to Rv0718,len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Probable rpsH, 30S ribosomal protein S8, equivalent to O32997|MLCB2492_18 30S RIBOSOMAL PROTEIN S8 from Mycobacterium leprae (132 aa). Also highly similar to others e.g. CAB82084.1|AL161803 30S ribosomal protein S8 from Streptomyces coelicolor (132 aa); P33106|RS8_MICLU 30s ribosomal protein S8 from Micrococcus luteus (132 aa), FASTA scores: opt: 669, E(): 0, (77.3% identity in 132 aa overlap); etc. Contains PS00053 Ribosomal protein S8 signature. BELONGS TO THE S8P FAMILY OF RIBOSOMAL PROTEINS.	X2BFX6,P66626,P66626	No	information pathways			P66626					X2BFX6,P66626					Rv0718		Rv0718			
NC_002945.3	Mycobrowser_v4	CDS	815220	815759	.	+	0	Mb0740	rplF		50s ribosomal protein l6 rplf	Mb0740, rplF, len: 179 aa. Equivalent to Rv0719,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable rplF, 50S ribosomal protein L6, equivalent to O32998|MLCB2492_19 50S RIBOSOMAL PROTEIN L6 from Mycobacterium leprae (179 aa). Also highly similar to others e.g. P46786|RL6_STRCO|CAB82085.1|AL161803|SCD31.42 50S ribosomal protein L6 from Streptomyces coelicolor (179 aa), FASTA scores: opt: 872, E(): 0, (70.4% identity in 179 aa overlap); etc. Contains PS00525 Ribosomal protein L6 signature 1. BELONGS TO THE L6P FAMILY OF RIBOSOMAL PROTEINS.	X2BFZ9,P66312,P66312	No	information pathways			P66312					X2BFZ9,P66312					Rv0719		Rv0719			
NC_002945.3	Mycobrowser_v4	CDS	816150	816812	.	+	0	Mb0742	rpsE		30s ribosomal protein s5 rpse	Mb0742, rpsE, len: 220 aa. Equivalent to Rv0721,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable rpsE, 30S ribosomal protein S5, equivalent to MLCB2492_21 RIBOSOMAL PROTEIN S5 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. P46790|RS5_STRCO 30s ribosomal protein S5 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 889, E(): 0, (82.1% identity in 162 aa overlap); etc. Note N-terminus is extented compared to other rpsE genes. Contains PS00585 Ribosomal protein S5 signature, PTS HPr component phosphorylation sites signature. BELONGS TO THE S5P FAMILY OF RIBOSOMAL PROTEINS.	X2BFT3,P66575,P66575	No	information pathways			P66575					X2BFT3,P66575					Rv0721		Rv0721			
NC_002945.3	Mycobrowser_v4	CDS	816815	817012	.	+	0	Mb0743	rpmD		50s ribosomal protein l30 rpmd	Mb0743, rpmD, len: 65 aa. Equivalent to Rv0722,len: 65 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 65 aa overlap). Probable rpmD, 50S ribosomal protein L30, equivalent to O33001 RIBOSOMAL PROTEIN L30 from Mycobacterium leprae (71 aa). Also highly similar to others e.g. P46789|RL30_STRCO 50S RIBOSOMAL PROTEIN L30 from Streptomyces coelicolor (60 aa); P02430|RL30_ECOLI 50S ribosomal protein L30 from Escherichia coli (58 aa), FASTA scores: opt: 168, E(): 1.5e-13, (53.7% identity in 54 aa overlap); etc. BELONGS TO THE L30P FAMILY OF RIBOSOMAL PROTEINS.	X2BFS7,P66182,P66182	No	information pathways			P66182					X2BFS7,P66182					Rv0722		Rv0722			
NC_002945.3	Mycobrowser_v4	CDS	817012	817452	.	+	0	Mb0744	rplO		50s ribosomal protein l15 rplo	Mb0744, rplO, len: 146 aa. Equivalent to Rv0723,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Probable rplO, 50S ribosomal protein L15, equivalent to MLCB2492_23|O33002 50S RIBOSOMAL PROTEIN L15 from Mycobacterium leprae (146 aa). Also highly similar to others e.g. P46787|RL15_STRCO|SCD31.46 50S RIBOSOMAL PROTEIN L15 from Streptomyces coelicolor (151 aa); P19946|RL15_BACSU 50s ribosomal protein L15 from Bacillus subtilis (146 aa),FASTA scores: opt: 419, E(): 6.5e-20, (51.0% identity in 145 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00475 Ribosomal protein L15 signature. BELONGS TO THE L15P FAMILY OF RIBOSOMAL PROTEINS.	X2BFY2,Q7U1E9,Q7U1E9	No	information pathways			Q7U1E9					X2BFY2,Q7U1E9					Rv0723		Rv0723			
NC_002945.3	Mycobrowser_v4	CDS	817485	819356	.	+	0	Mb0745	sppA		POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) (SIGNAL PEPTIDE PEPTIDASE)	Mb0745, sppA, len: 623 aa. Equivalent to Rv0724,len: 623 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 623 aa overlap). Possible sppA,protease IV (endopeptidase IV) (EC 3.4.21.-), equivalent (but longer 23 aa) to MLCB2492_24|O33003 ENDOPEPTIDASE IV from Mycobacterium leprae (602 aa). Also similar to others e.g. NP_419743.1|NC_002696 signal peptide peptidase SppA from Caulobacter crescentus (594 aa); P08395|SPPA_ECOLI|B1766 protease IV (endopeptidase) from Escherichia coli strain K-12 (618 aa), FASTA scores: opt: 582, E(): 8.9e-27, (34.1% identity in 525 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY S49.	Q7U1E8,A0A1R3XWB3	No	cell wall and cell processes			A0A1R3XWB3				IPR002142,IPR004634,IPR004635	Q7U1E8					Rv0724		Rv0724			
NC_002945.3	Mycobrowser_v4	CDS	821665	822321	.	-	0	Mb0748c	fucA		POSSIBLE L-FUCULOSE PHOSPHATE ALDOLASE FUCA (L-FUCULOSE-1-PHOSPHATE ALDOLASE)	Mb0748c, fucA, len: 218 aa. Equivalent to Rv0727c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 218 aa overlap). Possible fucA,L-fuculose-1-phosphate aldolase (EC 4.1.2.17), similar to many e.g. NP_386339.1|NC_003047 PUTATIVE L-FUCULOSE PHOSPHATE ALDOLASE PROTEIN from Sinorhizobium meliloti (222 aa); P11550|FUCA_ECOLI L-FUCULOSE PHOSPHATE ALDOLASE from Escherichia strain K12 (215 aa), FASTA scores: opt: 372, E(): 4.1e-19, (34.6% identity in 185 aa overlap); etc. BELONGS TO THE ALDOLASE CLASS II FAMILY, ARAD/FUCA SUBFAMILY. COFACTOR: BINDS ONE ZINC ION PER MOLECULE.	Q7U1E5,A0A1R3XWB0	No				A0A1R3XWB0				IPR001303	Q7U1E5										
NC_002945.3	Mycobrowser_v4	CDS	822318	823298	.	-	0	Mb0749c	serA2		POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA2 (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH)	Mb0749c, serA2, len: 326 aa. Equivalent to Rv0728c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 326 aa overlap). Possible serA2,D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95), similar to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (344 aa), FASTA scores: opt: 594, E(): 3.1e-31, (35.9% identity in 309 aa overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1 D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis (528 aa).	Q7U1E4,A0A1R3XW91	No				A0A1R3XW91				IPR006139,IPR006140,IPR006236,IPR016040	Q7U1E4										
NC_002945.3	Mycobrowser_v4	CDS	823329	824675	.	+	0	Mb0750	xylB		POSSIBLE D-XYLULOSE KINASE XYLB (XYLULOKINASE) (XYLULOSE KINASE)	Mb0750, xylB, len: 448 aa. Equivalent to Rv0729,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 448 aa overlap). Possible xylB,D-xylulose-kinase (xylulokinase) (EC 2.7.1.17). C-terminus highly similar to AAD09880.1|U77912 unknown protein from Mycobacterium bovis (102 aa); and N-terminus highly similar to T45387|Z98756|MLCB2492_25 hypothetical protein from Mycobacterium leprae (110 aa), FASTA scores: opt: 427, E(): 1.1e-19, (60.9% identity in 110 aa overlap). Also similar to xylA/xylB genes from various bacterial species e.g. AAC26499.1|AF045245 D-xylulose-kinase from Klebsiella pneumoniae (487 aa); NP_418021.1|NC_000913 xylulokinase from Escherichia coli strain K12 (484 aa),FASTA scores: opt: 260, E(): 7.5e-09, (25.9% identity in 478 aa overlap); etc. Also similar to Rv3696c|glpK PROBABLE GLYCEROL KINASE (EC 2.7.1.30) from Mycobacterium tuberculosis (517 aa). BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY.	Q7U1E3,A0A1R3XW81	No	intermediary metabolism and respiration			A0A1R3XW81				IPR018484,IPR018485	Q7U1E3					Rv0729		Rv0729			
NC_002945.3	Mycobrowser_v4	CDS	1500676	1501116	.	+	0	Mb1369	mec		possible hydrolase	Mb1369, -, len: 146 aa. Equivalent to Rv1334, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Conserved hypothetical protein, similar to AL096852|SCE19A_13 hypothetical protein from Streptomyces coelicolor (140 aa), Fasta scores: opt: 579, E(): 0, (65.0% identity in 140 aa overlap); and Q54330|M29166 MEC+ from Streptomyces kasugaensis (115 aa), FASTA scores; E(): 7.6e-33, (56.9% identity in 109 aa overlap).	X2BHM6,P64814,P64814	No	intermediary metabolism and respiration			P64814					X2BHM6,P64814					Rv1334		Rv1334			
NC_002945.3	Mycobrowser_v4	CDS	826622	827947	.	+	0	Mb0753	secY		PROBABLE PREPROTEIN TRANSLOCASE SECY	Mb0753, secY, len: 441 aa. Equivalent to Rv0732,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 441 aa overlap). Probable SecY,preprotein translocase (integral membrane protein),equivalent to NP_302243.1|NC_002677 SecY subunit of preprotein translocase from Mycobacterium leprae (438 aa); AAC04389.1|AF047021 preprotein translocase subunit from Mycobacterium smegmatis (438 aa); and U77912|MBU77912_1 preprotein translocase subunit from Mycobacterium bovis (441 aa), FASTA scores: opt: 2802, E(): 0, (99.8% identity in 441 aa overlap). Also highly similar to others e.g. P46785|SECY_STRCO PREPROTEIN TRANSLOCASE SECY SUBUNIT from Streptomyces coelicolor (437 aa); etc. Contains PS00755 and PS00756 protein secY signatures 1 and 2. BELONGS TO THE SECE/SEC61-ALPHA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c,SECG|Rv1440 AND SECY.	X2BFT9,P0A5Z3,P0A5Z3	No	cell wall and cell processes			P0A5Z3					X2BFT9,P0A5Z3					Rv0732		Rv0732			
NC_002945.3	Mycobrowser_v4	CDS	827944	828489	.	+	0	Mb0754	adk		adenylate kinase adk (atp-amp transphosphorylase)	Mb0754, adk, len: 181 aa. Equivalent to Rv0733,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Probable adk,adenylate kinase (ATP-AMP transphosphorylase) (EC 2.7.4.3), equivalent to Z98756|MLCB24 92_28 probable adenylate kinase from Mycobacterium leprae (181 aa), FASTA scores: opt: 978, E(): 0, (83.6% identity in 177 aa overlap); and AAF86323.1|AF271342 putative adenylate kinase from Mycobacterium marinum (124 aa) (N-terminus shorter). Also highly similar to others e.g. P43414|KAD_STRCO ADENYLATE KINASE from Streptomyces coelicolor (217 aa), FASTA score: (43.0% identity in 186 aa overlap); etc. Contains PS00113 Adenylate kinase signature. BELONGS TO THE ADENYLATE KINASE FAMILY.	X2BFZ4,P69439,P69439	No	intermediary metabolism and respiration			P69439					X2BFZ4,P69439					Rv0733		Rv0733			
NC_002945.3	Mycobrowser_v4	CDS	828492	829292	.	+	0	Mb0755	mapA		methionine aminopeptidase mapa (map) (peptidase m) (metap)	Mb0755, mapA, len: 266 aa. Equivalent to Rv0734,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable mapA,methionine aminopeptidase (map) (EC 3.4.11.18), equivalent to Z98756|MLCB2492_29 probable methionine aminopeptidase from Mycobacterium leprae (266 aa), FASTA scores: opt: 1717, E(): 0, (83.4% identity in 265 aa overlap). Also highly similar to many e.g. T35553 methionine aminopeptidase from Streptomyces coelicolor (278 aa); etc. Also similar to Rv2861c|MAPB PROBABLE METHIONINE AMINOPEPTIDASE from Mycobacterium tuberculosis (285 aa). BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT.	O53797,A0A1R3XWC1	No	intermediary metabolism and respiration			A0A1R3XWC1				IPR000994,IPR001714,IPR002467	O53797					Rv0734		Rv0734			
NC_002945.3	Mycobrowser_v4	CDS	829365	829898	.	+	0	Mb0756	sigL		PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGL	Mb0756, sigL, len: 177 aa. Equivalent to Rv0735,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). Probable sigL,alternative RNA polymerase sigma factor (rpoE) (see citation below), highly similar to many proteins of the extracytoplasmatic function (ECF) subfamily e.g. CAB72200.1|AL138851 putative RNA polymerase sigma factor from Streptomyces coelicolor (194 aa); Q06909|CARQ_MYXXA RNA POLYMERASE SIGMA FACTOR CARQ from Myxococcus xanthus (174 aa), FASTA scores: opt: 251, E(): 9.6e-11, (32.9% identity in 161 aa overlap); etc. Also similar to MTCI61_4, MTU87242_1, and MLU15180_30 from Mycobacterium tuberculosis. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 139-160 (Score 1134, +3.05 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY.	O53798,A0A1R3XWN4	No	information pathways			A0A1R3XWN4				IPR000838,IPR007627,IPR007630,IPR011991,IPR013324,IPR013325,IPR014284	O53798					Rv0735		Rv0735			
NC_002945.3	Mycobrowser_v4	CDS	829962	830714	.	+	0	Mb0757	rsla		anti-sigma factor rsla	Mb0757, -, len: 250 aa. Equivalent to Rv0736, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Probable conserved membrane protein, showing weak similarity with AL133469|SCM10_32 putative membrane protein from Streptomyces coelicolor (216 aa), FASTA scores: opt: 180,E(): 0.00018, (34.3% identity in 216 aa overlap).	O53799,A0A1R3XW87	No	information pathways			A0A1R3XW87				IPR027383	O53799					Rv0736		Rv0736			
NC_002945.3	Mycobrowser_v4	CDS	834814	835332	.	+	0	Mb0763	PE_PGRS8		pe-pgrs family protein pe_pgrs8	Mb0763, PE_PGRS8, len: 172 aa. Equivalent to Rv0742, len: 172 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 172 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many M. tuberculosis PGRS-type proteins e.g. Z78020|MTCY1A11_25 (498 aa), FASTA scores: opt: 766, E(): 6.1e-25, (73.6% identity in 178 aa overlap). Similarity suggests ORF starts with ATA start codon.	Q7U1D8,A0A1R3XYE7	No	PE/PPE			A0A1R3XYE7				IPR000084	Q7U1D8					Rv0742		Rv0742			
NC_002945.3	Mycobrowser_v4	CDS	837525	839918	.	+	0	Mb0767	PE_PGRS9		pe-pgrs family protein pe_pgrs9	Mb0767, PE_PGRS9, len: 797 aa. Equivalent to Rv0746, len: 783 aa, from Mycobacterium tuberculosis strain H37Rv, (89.7% identity in 829 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2429, E(): 0,(56.9% identity in 873 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. AL0212|MTV008_46 FASTA score: (48.8% identity in 887 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa).	Q7U1D4,A0A1R3XW92	No	PE/PPE			A0A1R3XW92				IPR000084	Q7U1D4					Rv0746		Rv0746			
NC_002945.3	Mycobrowser_v4	CDS	840317	843046	.	+	0	Mb0768	PE_PGRS10		pe-pgrs family protein pe_pgrs10	Mb0768, PE_PGRS10, len: 909 aa. Equivalent to Rv0747, len: 801 aa, from Mycobacterium tuberculosis strain H37Rv, (86.6% identity in 912 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2772, E(): 0,(60.9% identity in 941 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. Z95844|MTCY493_2 FASTA score: (50.2% identity in 815 aa overlap). Contains PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (cggcaacgg-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa versus 801 aa).	Q7U1D3,A0A1R3XWC7	No				A0A1R3XWC7				IPR000084	Q7U1D3										
NC_002945.3	Mycobrowser_v4	CDS	844537	845421	.	-	0	Mb0773c	mmsB		PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH)	Mb0773c, mmsB, len: 294 aa. Equivalent to Rv0751c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 294 aa overlap). Probable mmsB,3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31), highly similar to others e.g. NP_102847.1|NC_002678 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti (294 aa); NP_420167.1|NC_002696 3-hydroxyisobutyrate dehydrogenase from Caulobacter crescentus (298 aa); A32867 3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus (346 aa); etc. Also similar to methylmalonate semialdehyde dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate semialdehyde dehydrogenase from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 786, E(): 0, (45.8% identity in 297 aa overlap). Also similar to 6-phosphogluconate dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. Contains PS00895 3-hydroxyisobutyrate dehydrogenase signature. BELONGS TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY.	X2BFW4,P63936,P63936	No				P63936					X2BFW4,P63936										
NC_002945.3	Mycobrowser_v4	CDS	845432	846604	.	-	0	Mb0774c	fadE9		PROBABLE ACYL-COA DEHYDROGENASE FADE9	Mb0774c, fadE9, len: 390 aa. Equivalent to Rv0752c,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 390 aa overlap). Probable fadE9,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. NP_437985.1|NC_003078 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (380 aa); Z99123|BSUB0020_14 from Bacillus subtilis (379 aa),FASTA scores: opt: 853, E(): 0, (39.8% identity in 384 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, and PS00073 Acyl-Co Adehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7U1C8,A0A1R3XXB2	No				A0A1R3XXB2				IPR006089,IPR006091,IPR009075,IPR009100,IPR013786	Q7U1C8										
NC_002945.3	Mycobrowser_v4	CDS	846611	848143	.	-	0	Mb0775c	mmsA		PROBABLE METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE MMSA (METHYLMALONIC ACID SEMIALDEHYDE DEHYDROGENASE) (MMSDH)	Mb0775c, mmsA, len: 510 aa. Equivalent to Rv0753c,len: 510 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 510 aa overlap). Probable mmsA,methylmalonic acid semialdehyde dehydrogenase (EC 1.2.1.27), highly similar to others e.g. NP_420115.1|NC_002696 putative methylmalonate-semialdehyde dehydrogenase from Caulobacter crescentus (499 aa); L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor (500 aa), FASTA score: (51.6% identity in 498 aa overlap); M84911|PSEMMSRAB_2|NP_252260.1|NC_002516 methylmalonate-semialdehyde dehydrogenase from Pseudomonas aeruginosa (497 aa), FASTA scores: opt: 1127, E(): 0,(47.9% identity in 507 aa overlap); etc. Note that also highly similar to malonic semialdehyde oxidative decarboxylases e.g. NP_104968.1|NC_002678 malonic semialdehyde oxidative decarboxylase from Mesorhizobium loti (498 aa); NP_384832.1|NC_003047 PUTATIVE MALONIC SEMIALDEHYDE OXIDATIVE DECARBOXYLASE PROTEIN from Sinorhizobium meliloti (498 aa); etc. Contains PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.	Q7U1C7,A0A1R3XWE3	No				A0A1R3XWE3				IPR010061,IPR015590,IPR016160,IPR016161,IPR016162,IPR016163	Q7U1C7										
NC_002945.3	Mycobrowser_v4	CDS	854586	856043	.	+	0	Mb0781	phoR		POSSIBLE TWO COMPONENT SYSTEM RESPONSE SENSOR KINASE MEMBRANE ASSOCIATED PHOR	Mb0781, phoR, len: 485 aa. Equivalent to Rv0758,len: 485 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 485 aa overlap). Possible phoR, two component system response phosphate sensor kinase membrane-associated (EC 2.7.-.-), highly similar to various sensor kinases e.g. CAC32361.1|AL583945 putative two component system histidine kinase from Streptomyces coelicolor (524 aa); NP_349365.1|NC_003030 Membrane-associated sensory histidine kinase with HAMP domain from Clostridium acetobutylicum (482 aa); and similar to phoP proteins e.g. NP_372216.1|NC_002758 alkaline phosphatase synthesis sensor protein from Staphylococcus aureus (554 aa); P23545|PHOR_BACSU alkaline phosphatase synthesis sensor from Bacillus subtilis (579 aa), FASTA scores: opt: 515, E(): 1.9e-25, (40.0% identity in 230 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. MTCY20G9.16 FASTA scores: (34.5% identity in 264 aa overlap), MTU88959_2 (509 aa),MTCY10G2_17, etc.	Q7U1C1,A0A1R3XWC2	No	regulatory proteins			A0A1R3XWC2				IPR003594,IPR003660,IPR003661,IPR004358,IPR005467,IPR009082	Q7U1C1					Rv0758		Rv0758			
NC_002945.3	Mycobrowser_v4	CDS	848349	850103	.	+	0	Mb0776	PE_PGRS11		pe-pgrs family protein pe_pgrs11	Mb0776, PE_PGRS11, len: 584 aa. Equivalent to Rv0754, len: 584 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 584 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. AL0212|MTV008_46 from Mycobacterium tuberculosis (1660 aa), FASTA score: (48.7% identity in 345 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa),FASTA score: (41.6% identity in 442 aa overlap); etc.	Q7U1C6,A0A1R3XWQ3	No				A0A1R3XWQ3				IPR000084,IPR013078	Q7U1C6										
NC_002945.3	Mycobrowser_v4	CDS	850293	852230	.	-	0	Mb0777c	PPE12		ppe family protein ppe12	Mb0777c, PPE12, len: 645 aa. Equivalent to Rv0755c,len: 645 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 645 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to others e.g. Z82098|MTCY3C7_23 from Mycobacterium tuberculosis (582 aa), FASTA scores: (56.1% identity in 636 aa overlap); Z92774|MTCY6G11_5 from Mycobacterium tuberculosis (552 aa), FASTA scores: (55.8% identity in 590 aa overlap); etc.	Q7U1C5,A0A1R3XW96	No				A0A1R3XW96				IPR000030,IPR002989	Q7U1C5										
NC_002945.3	Mycobrowser_v4	CDS	1501138	1501419	.	+	0	Mb1370	cyso		sulfur carrier protein cyso	Mb1370, -, len: 93 aa. Equivalent to Rv1335, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 93 aa overlap). 9.5 kDa culture filtrate antigen cfp10A (see citation below). Similar to hypothetical proteins from other organisms e.g. P74060|D90911 Synechocystis (109 aa), FASTA scores: E(): 2.3e-20, (49.5% identity in 93 aa overlap).	X2BHE1,P0A647,P0A647	No	intermediary metabolism and respiration			P0A647					X2BHE1,P0A647					Rv1335		Rv1335			
NC_002945.3	Mycobrowser_v4	CDS	853798	854541	.	+	0	Mb0780	phoP		POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP	Mb0780, phoP, len: 247 aa. Equivalent to Rv0757,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Possible phoP, two component system response phosphate regulon transcriptional regulator, highly similar to various transcriptional regulators e.g. CAC32360.1|AL583945 putative two component system response regulator from Streptomyces coelicolor (271 aa); T45446 probable two-component response regulator from Mycobacterium leprae (253 aa); and similar to phoP proteins e.g. P13792|PHOP_BACSU alkaline phosphatase synthesis transcription regulatory protein from Bacillus subtilis (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, (41.0% identity in 234 aa overlap); etc. Also highly similar to Rv3765c from Mycobacterium tuberculosis (234 aa), Rv1033c (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa), FASTA score: (45.4% identity in 229 aa overlap); MTCY10G2_16 and MTU88959_1.	Q7U1C2,A0A1R3XWA9	No	regulatory proteins			A0A1R3XWA9				IPR001789,IPR001867,IPR011006,IPR011991,IPR016032	Q7U1C2					Rv0757		Rv0757			
NC_002945.3	Mycobrowser_v4	CDS	856888	858015	.	-	0	Mb0784c	adhB		possible zinc-containing alcohol dehydrogenase nad dependent adhb	Mb0784c, adhB, len: 375 aa. Equivalent to Rv0761c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Possible adhB,zinc-containing alcohol dehydrogenase NAD-dependant (EC 1.1.1.1), similar to others e.g. AAC15839.1|AF060871_4 hypothetical alcohol dehydrogenase from Rhodococcus rhodochrous (370 aa), FASTA scores: opt: 1234, E(): 0,(46.8% identity in 370 aa overlap); P80468|ADH2_STRCA ALCOHOL DEHYDROGENASE II from Struthio camelus (Ostrich) (379 aa); Q03505|ADH1_RABIT alcohol dehydrogenase alpha chain from Oryctolagus cuniculus (Rabbit) (374 aa), FASTA scores: opt: 872, E(): 0, (39.1% identity in 379 aa overlap); etc. Also similar to adhD alcohol dehydrogenase from Mycobacterium tuberculosis (368 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY.	X2BG32,Q7U1B9,Q7U1B9	No				Q7U1B9					X2BG32,Q7U1B9										
NC_002945.3	Mycobrowser_v4	CDS	858871	860226	.	-	0	Mb0787c	cyp51		CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM)	Mb0787c, cyp51, len: 451 aa. Equivalent to Rv0764c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). cyp51, cytochrome P450 51 (sterol 14-alpha demethylase) (EC 1.14.14.-),similar to others e.g. Q16850|CP51_HUMAN CYTOCHROME P450 51 (CYPL1) (P450L1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Homo sapiens (509 aa), FASTA scores: opt: 848, E(): 0, (33.9% identity in 439 aa overlap); NP_172633.1|NC_003070 putative obtusifoliol 14-alpha demethylase from Arabidopsis thaliana (488 aa); P93596|CP51_WHEAT CYTOCHROME P450 51 (CYPL1) (P450-L1A1) (OBTUSIFOLIOL 14-ALPHA DEMETHYLASE) from Triticum aestivum (453 aa); etc. Also similar to many other Mycobacterium tuberculosis cytochromes P450 e.g. Rv1394c, FASTA score: (22.5% identity in 444 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.	X2BFW1,P0A513,P0A513	No				P0A513					X2BFW1,P0A513										
NC_002945.3	Mycobrowser_v4	CDS	861053	862261	.	-	0	Mb0789c	cyp123		PROBABLE CYTOCHROME P450 123 CYP123	Mb0789c, cyp123, len: 402 aa. Equivalent to Rv0766c, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 402 aa overlap). Probable cyp123, cytochrome P-450 (EC 1.14.-.-), similar to others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 from Saccharopolyspora erythraea (405 aa), FASTA scores: opt: 770, E(): 0, (36.9% identity in 406 aa overlap); T36526 probable cytochrome P450 hydroxylase from Streptomyces coelicolor (411 aa); P27632|CPXM_BACSU CYTOCHROME P450 109 from Bacillus subtilis (405 aa); etc. Also similar to several other cytochromes P-450 from Mycobacterium tuberculosis e.g. Rv1256c|MTCY50.26 (405 aa), FASTA score: (35.2% identity in 389 aa overlap); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.	X2BG36,P63708,P63708	No	intermediary metabolism and respiration			P63708					X2BG36,P63708					Rv0766c		Rv0766c			
NC_002945.3	Mycobrowser_v4	CDS	863101	864570	.	+	0	Mb0791	aldA		probable aldehyde dehydrogenase nad dependent alda (aldehyde dehydrogenase [nad+])	Mb0791, aldA, len: 489 aa. Equivalent to Rv0768,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 489 aa overlap). Probable aldA,NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid dehydrogenase from Rhodococcus ruber (474 aa); NP_285450.1|NC_001264 aldehyde dehydrogenase from Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570 NADP-dependent aldehyde dehydrogenase from Bacillus halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde dehydrogenase precursor from Atriplex hortensis (Mountain spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6% identity in 486 aa overlap); etc. Also highly similar to Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium tuberculosis (487 aa). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.	Q7TTS0,A0A1R3XWD8	No	intermediary metabolism and respiration			A0A1R3XWD8				IPR015590,IPR016160,IPR016161,IPR016162,IPR016163,IPR026460	Q7TTS0					Rv0768		Rv0768			
NC_002945.3	Mycobrowser_v4	CDS	866775	868043	.	+	0	Mb0795	purD		PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)	Mb0795, purD, len: 422 aa. Equivalent to Rv0772,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Probable purD,phosphoribosylamine--glycine ligase (EC 6.3.4.13),equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08 PHOSPHORIBOSYLAMINE--GLYCINE LIGASE from Mycobacterium leprae (422 aa), FASTA scores: opt: 2272, E(): 0, (81.8% identity in 422 aa overlap). Also highly similar to others e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine ligase from Streptomyces coelicolor (416 aa); P1564|PUR2_ECOLI phosphoribosylamine--glycine ligase from Escherichia coli (429 aa), FASTA scores: opt: 1039, E(): 0, (42.7% identity in 431 aa overlap); etc. BELONGS TO THE GARS FAMILY.	X2BG60,P65894,P65894	No	intermediary metabolism and respiration			P65894					X2BG60,P65894					Rv0772		Rv0772			
NC_002945.3	Mycobrowser_v4	CDS	868040	869578	.	-	0	Mb0796c	ggtA		PROBABLE BIFUNCTIONAL ACYLASE GGTA: CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE) + GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)	Mb0796c, ggtA, len: 512 aa. Equivalent to Rv0773c,len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Probable ggtA,bifunctional acylase including cephalosporin acylase (EC 3.5.1.-), and gamma-glutamyl transpeptidase (EC 2.3.2.2); highly similar to others e.g. NP_295247.1|NC_001263 cephalosporin acylase from Deinococcus radiodurans (535 aa); NP_248854.1|NC_002516 probable gamma-glutamyltranspeptidase from Pseudomonas aeruginosa (538 aa); P15557|PAC1_PSES3 ACYLASE ACY 1 [INCLUDES: CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE); GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)] from Pseudomonas sp. strain SE83 (558 aa), FASTA scores: opt: 784, E(): 0,(34.2% identity in 526 aa overlap); NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein similar to gamma-glutamyltransferase from Bacillus subtilis (525 aa), FASTA scores: opt: 1169, E(): 0, (40.1% identity in 516 aa overlap); etc. Also similar to Rv2394|ggtB from Mycobacterium tuberculosis. Member of GL-7ACA ACYLASES AND TO GGT group.	Q7U1B2,A0A1R3XWS1	No				A0A1R3XWS1				IPR000101	Q7U1B2										
NC_002945.3	Mycobrowser_v4	CDS	892302	893099	.	-	0	Mb0821c	cfp29		29 KDa ANTIGEN CFP29	Mb0821c, cfp29, len: 265 aa. Equivalent to Rv0798c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). cfp29, 29 kDa antigen (see citations below). Highly similar to Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from Brevibacterium linens (266 aa), FASTA scores: (58.5% identity in 265 aa overlap). Also shows similarity with NP_228594.1|NC_000853 bacteriocin from Thermotoga maritima (262 aa).	Q7U190,A0A1R3XWH2	No				A0A1R3XWH2				IPR007544	Q7U190										
NC_002945.3	Mycobrowser_v4	CDS	872197	873615	.	+	0	Mb0800	purB		PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) (ASL) (ASASE)	Mb0800, purB, len: 472 aa. Equivalent to Rv0777,len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable purB,adenylosuccinate lyase (EC 4.3.2.2), equivalent (but shorter 15 aa) to MLCB5.13|Z95151|g2076607|PURB ADENYLOSUCCINATE LYASE from Mycobacterium leprae (487 aa),FASTA scores: opt: 2640, E(): 0, (86.7% identity in 472 aa overlap). More similar to eukaryotic adenylosuccinate lyases than to prokaryotic adenylosuccinate lyases e.g. P54822|PUR8_MOUSE ADENYLOSUCCINATE LYASE from Mus musculus (484 aa), FASTA scores: opt: 762, E(): 0, (32.4% identity in 445 aa overlap); CAB99134.1|AL390188 putative adenylosuccino lyase (fragment) from Streptomyces coelicolor (362 aa); etc. Contains PS00163 Fumarate lyases signature. BELONGS TO THE LYASE 1 FAMILY, ADENYLOSSUCINATE LYASE SUBFAMILY.	Q7U1A8,A0A1R3XWE6	No	intermediary metabolism and respiration			A0A1R3XWE6				IPR000362,IPR004769,IPR008948,IPR019468,IPR020557,IPR022761,IPR024083	Q7U1A8					Rv0777		Rv0777			
NC_002945.3	Mycobrowser_v4	CDS	873620	874864	.	+	0	Mb0801	cyp126		POSSIBLE CYTOCHROME P450 126 CYP126	Mb0801, cyp126, len: 414 aa. Equivalent to Rv0778,len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Possible cyp126,cytochrome P-450 (EC 1.14.-.-), similar to other cytochromes and related proteins e.g. AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1 cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28) (lin C) from Pseudomonas incognita (406 aa), FASTA scores: opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature.	X2BG53,P63712,P63712	No				P63712					X2BG53,P63712										
NC_002945.3	Mycobrowser_v4	CDS	875532	876425	.	+	0	Mb0803	purC		PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE PURC (SAICAR SYNTHETASE)	Mb0803, purC, len: 297 aa. Equivalent to Rv0780,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 297 aa overlap). purC,phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (see citations below), equivalent to MTU34957_1|PURC phosphoribosylaminoimidazole-succinocarboxamide synthase from Mycobacterium leprae (297 aa), FASTA scores: opt: 1986, E(): 0, (99.3% identity in 297 aa overlap). Also similar to others e.g. CAB56351.1|AL118514 phosphoribosylaminoimidazole-succinocarboxamide synthase from Streptomyces coelicolor (299 aa); etc. Contains PS01058 SAICAR synthetase signature 2. BELONGS TO THE SAICAR SYNTHETASE FAMILY.	X2BG03,P0A5T5,P0A5T5	No	intermediary metabolism and respiration			P0A5T5					X2BG03,P0A5T5					Rv0780		Rv0780			
NC_002945.3	Mycobrowser_v4	CDS	876422	878581	.	+	0	Mb0804	ptrB		probable protease ii ptrbb [second part] (oligopeptidase b)	Mb0804, ptrB, len: 719 aa. Equivalent to Rv0781 and Rv0782, len: 236 aa and 552 aa, from Mycobacterium tuberculosis strain H37Rv, (97.6% identity in 206 aa overlap and 100.0% identity in 517 aa overlap). Probable ptrB, protease II (EC 3.4.21.83), equivalent to NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to C-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa),FASTA scores: opt: 204, E(): 7.4e-07, (29.6% identity in 230 aa overlap); etc. Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa), FASTA scores: opt: 1251, E(): 0, (42.7% identity in 489 aa overlap); etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II, but we can find no error in the cosmid sequence to account for this. BELONGS TO PEPTIDASE FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. Note that previously known as ptrBb. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes,ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis, a 2 bp insertion (*-gc) leads to a single product.	Q7U1A6,A0A1R3XXD9	No	intermediary metabolism and respiration			A0A1R3XXD9				IPR001375,IPR002470,IPR023302	Q7U1A6					Rv0781		Rv0781			
NC_002945.3	Mycobrowser_v4	CDS	884950	885624	.	+	0	Mb0812	purQ		PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I PURG (FGAM SYNTHASE I)	Mb0812, purQ, len: 224 aa. Equivalent to Rv0788,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable purQ,phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3),equivalent to MLCB5_24|Z95151|O05756|PURQ PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from Mycobacterium leprae (224 aa), FASTA scores: opt: 1341,E(): 0, (88.7% identity in 222 aa overlap). Also highly similar to others e.g. P12041|PURQ_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from Bacillus subtilis (227 aa), FASTA scores: opt: 691, E(): 8.6e-39,(47.7% identity in 214 aa overlap); etc. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO TYPE-1 GLUTAMINE AMIDOTRANSFERASES.	X2BFY1,P65903,P65903	No	intermediary metabolism and respiration			P65903					X2BFY1,P65903					Rv0788		Rv0788			
NC_002945.3	Mycobrowser_v4	tRNA	924940	925013	.	+	0	aspT	aspT		tRNA-Asp	aspT, len: 74 nt. Equivalent to aspT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Asp, anticodon gtc.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	925043	925116	.	+	0	pheU	pheU		tRNA-Phe	pheU, len: 74 nt. Equivalent to pheU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Phe, anticodon gaa.		No																			
NC_002945.3	Mycobrowser_v4	CDS	879009	880631	.	-	0	Mb0805c	emrB		POSSIBLE MULTIDRUG RESISTANCE INTEGRAL MEMBRANE EFFLUX PROTEIN EMRB	Mb0805c, emrB, len: 540 aa. Equivalent to Rv0783c,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). Possible emrB,integral membrane drug efflux protein, member of major facilitator superfamily (MFS), equivalent to AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from Mycobacterium avium (538 aa). Also similar to other membrane proteins e.g. CAB61606.1|AL133210 putative export protein from Streptomyces coelicolor (496 aa); NP_108371.1|NC_002678 efflux pump protein FarB from Mesorhizobium loti (511 aa); P44927|EMRB_HAEINHI0897| multidrug resistance protein b homologue from Haemophilus influenzae (510 aa), FASTA scores: opt: 706, E(): 1.3e-36,(30.4% identity in 408 aa overlap); etc. Also similar to Rv2333c|MTCY3G12.01 from Mycobacterium tuberculosis (537 aa), FASTA score: (28.2% identity in 408 aa overlap); and Rv1410c|MTCY21B4.27c from Mycobacterium tuberculosis (518 aa), FASTA score: (26.8% identity in 496 aa overlap). BELONGS TO THE MAJOR FACILITATOR FAMILY; ALSO KNOWN AS THE DRUG RESISTANCE TRANSLOCASE FAMILY.	Q7U1A5,A0A1R3XWG7	No				A0A1R3XWG7				IPR004638,IPR011701,IPR016196,IPR020846	Q7U1A5										
NC_002945.3	Mycobrowser_v4	CDS	894148	895449	.	+	0	Mb0823	pepC		PROBABLE AMINOPEPTIDASE PEPC	Mb0823, pepC, len: 433 aa. Equivalent to Rv0800,len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 433 aa overlap). Probable pepC,aminopeptidase I (EC 3.4.11.-), highly similar (but shorter 17 aa) to Q50022|PEPX AMINOPEPTIDASE from Mycobacterium leprae (443 aa), FASTA scores: opt: 2237,E(): 0, (78.3% identity in 433 aa overlap). Also highly similar to others from Eukaryotes and bacteria, e.g. T36482 probable aminopeptidase from Streptomyces coelicolor (432 aa), P14904|AMPL_YEAST vacuolar aminopeptidase I precursor from Saccharomyces cerevisiae (514 aa), FASTA scores: opt: 425, E(): 4.8e-21, (31.0% identity in 445 aa overlap); etc. Also similar to hypothetical proteins e.g. P38821|YHR3_YEAST hypothetical 54.2 kd protein from Saccharomyces cerevisiae (490 aa),FASTA scores: opt: 429, E(): 2.5e-21, (34.8% identity in 443 aa overlap); etc.	X2BG29,P59951,P59951	No	intermediary metabolism and respiration			P59951					X2BG29,P59951					Rv0800		Rv0800			
NC_002945.3	Mycobrowser_v4	CDS	896650	898914	.	+	0	Mb0826	purL		PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II)	Mb0826, purL, len: 754 aa. Equivalent to Rv0803,len: 754 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 754 aa overlap). purL,phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3) (see citations below), equivalent to NP_302451.1|NC_002677 phosphoribosylformylglycinamidine synthase II from Mycobacterium leprae (754 aa). Also highly similar to others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor (752 aa); P12042|PURL_BACSU from Bacillus subtilis (742 aa), FASTA score: (44.7% identity in 716 aa); etc. Start was chosen by similarity. BELONGS TO THE FGAMS FAMILY.	X2BG81,P0A5T9,P0A5T9	No	intermediary metabolism and respiration			P0A5T9					X2BG81,P0A5T9					Rv0803		Rv0803			
NC_002945.3	Mycobrowser_v4	CDS	900562	902160	.	-	0	Mb0829c	cpsY		POSSIBLE UDP-GLUCOSE-4-EPIMERASE CPSY (GALACTOWALDENASE) (UDP-GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE-4-EPIMERASE)	Mb0829c, cpsY, len: 532 aa. Equivalent to Rv0806c,len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 532 aa overlap). Possible cpsY,UDP-glucose-4-epimerase (EC 5.1.3.2), equivalent to Q50025|CPSY probable UDP-glucose-4-epimerase from Mycobacterium leprae (542 aa), FASTA scores: opt: 2964,E(): 0, (82.3% identity in 530 aa overlap). Also similar to AAC38286.1|AF019760|SACB CpsY homolog (involved in meningococcal capsule biosynthesis) from Neisseria meningitidis serogroup A (545 aa); Q51151 CAPSULE GENE COMPLEX UPD-GLUCOSE-4-EPIMERASE (GALE) from Neisseria meningitidis (373 aa), FASTA scores: opt: 496, E(): 9.5e-27, (29.3% identity in 358 aa overlap); C-terminus of CAB75373.1|AL139298 putative transferase from Streptomyces coelicolor (942 aa); and many hypothetical proteins from Streptomyces coelicolor. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY.	X2BG73,Q7U184,Q7U184	No				Q7U184					X2BG73,Q7U184										
NC_002945.3	Mycobrowser_v4	CDS	902941	904524	.	+	0	Mb0831	purF		amidophosphoribosyltransferase purf (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpatase)	Mb0831, purF, len: 527 aa. Equivalent to Rv0808,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 527 aa overlap). Probable purF,amidophosphoribosyltransferase (EC 2.4.2.14), equivalent to MLCB5_32|Q50028|PURF from Mycobacterium leprae (556 aa), FASTA scores: (91.3% identity in 518 aa overlap); and CAB96578.1|AJ278609 phosphoribosyl pyrophosphate amidotransferase from Mycobacterium smegmatis (511 aa). Also highly similar to others e.g. BAA89439.1|AB003158 amidophosphoribosyl transferase from Corynebacterium ammoniagenes (490 aa); P00497|PUR1_BACSU amidophosphoribosyltransferase precursor from Bacillus subtilis (476 aa), FASTA scores: opt: 1412, E(): 0, (46.2% identity in 470 aa overlap); etc. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY.	X2BG87,P65830,P65830	No	intermediary metabolism and respiration			P65830					X2BG87,P65830					Rv0808		Rv0808			
NC_002945.3	Mycobrowser_v4	CDS	904555	905649	.	+	0	Mb0832	purM		PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE)	Mb0832, purM, len: 364 aa. Equivalent to Rv0809,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Probable purM,5'-phosphoribosyl-5-aminoimidazole synthetase (EC 6.3.3.1), equivalent to NP_302446.1|NC_002677 5'-phosphoribosyl-5-aminoimidazole synthase from Mycobacterium leprae (364 aa). Also highly similar to many e.g. P12043|PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE from Bacillus subtilis (346 aa), FASTA scores: opt: 1023, E(): 0, (46.5% identity in 331 aa overlap); U68765|STU68765_2 from Salmonella typhimurium (345 aa), FASTA scores: opt: 1014, E():0, (47.6% identity in 330 aa overlap); etc.	Q7U182,A0A1R3XWH4	No	intermediary metabolism and respiration			A0A1R3XWH4				IPR000728,IPR004733,IPR010918,IPR016188	Q7U182					Rv0809		Rv0809			
NC_002945.3	Mycobrowser_v4	CDS	909011	909313	.	-	0	Mb0837c	sseC2		conserved protein ssec2	Mb0837c, sseC2, len: 100 aa. Equivalent to Rv0814c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). sseC2, conserved hypothetical protein, highly similar to AAA62972.1|U15182|MLU15182_17 hypothetical protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 545,E(): 0, (84.0% identity in 100 aa overlap); and NP_302441.1|NC_002677|Z95150|MTCY164_29 conserved hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 647, E(): 0, (100.0% identity in 100 aa overlap). Also highly similar to M29612|SERCYSA_5 rhodanese-like protein from Saccharopolyspora erythraea (101 aa), FASTA scores: opt: 345, E(): 1.2e-18, (57.1% identity in 98 aa overlap); and similar at the C-terminus to the C-terminus of CAB94069.1|AL358692 conserved hypothetical protein from Streptomyces coelicolor (95 aa). Identical second copy present as Rv3118|MTCY164.28|SSEC1 from Mycobacterium tuberculosis (100 aa) (100.0% identity in 100 aa overlap).	Q7U177,A0A1R3XWI1	No				A0A1R3XWI1				IPR008969,IPR010814,IPR014766	Q7U177										
NC_002945.3	Mycobrowser_v4	CDS	909315	910148	.	-	0	Mb0838c	cysA2		PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)	Mb0838c, cysA2, len: 277 aa. Equivalent to Rv0815c,len: 277 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 277 aa overlap). Probable cysA2,thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER PUTATIVE THIOSULFATE SULFURTRANSFERASE from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa); NP_293941.1|NC_001263 thiosulfate sulfurtransferase from Deinococcus radiodurans (286 aa); etc. Identical second copy present as Rv3117|MTCY164.27|MT3199|O05793|cysA3 (277 aa) (100.0% identity in 277 aa overlap). Contains PS00683 Rhodanese C-terminal signature at C-terminus. BELONGS TO THE RHODANESE FAMILY.	X2BG48,P59989,P59989	No				P59989					X2BG48,P59989										
NC_002945.3	Mycobrowser_v4	CDS	910441	910863	.	-	0	Mb0839c	thiX		PROBABLE THIOREDOXIN THIX	Mb0839c, thiX, len: 140 aa. Equivalent to Rv0816c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap). Probable thiX,thioredoxin (EC 1.-.-.-), equivalent to ThiX|U15182|MLU15182_21 thioredoxin from Mycobacterium leprae (172 aa), FASTA scores: opt: 556, E(): 8.8e-31,(63.8% identity in 141 aa overlap); and similar to AAL08576.1|AF418548_2|AF418548 thioredoxin from Mycobacterium avium subsp. paratuberculosis (117 aa). Also similar to other bacterial thioredoxins e.g. CAB95303.1|AL359779 putative thioredoxin from Streptomyces coelicolor (126 aa); P33791|THIO_STRAU|TRX|TRXA THIOREDOXIN from Streptomyces aureofaciens (106 aa); etc. And similar to Rv3914|MT4033|MTV028.05|NP_218431.1|NC_000962|trxC THIOREDOXIN (TRX) (MPT46) from Mycobacterium tuberculosis (116 aa). Has hydrophobic stretch at N-terminus. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY.	Q7U176,A0A1R3XWH9	No				A0A1R3XWH9				IPR005746,IPR012336,IPR013766	Q7U176										
NC_002945.3	Mycobrowser_v4	CDS	1240787	1240984	.	+	0	Mb1143	vapb32		possible antitoxin vapb32	Mb1143, -, len: 65 aa. Equivalent to Rv1113, len: 65 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 65 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2758c|AL00896 7|MTV002.23 (88 aa) FASTA scores: opt: 97, E(): 0.86, (33.3% identity in 69 aa overlap). Part of family including Rv2871, Rv1241, Rv2132,Rv3321c, etc.	Q7U0M5,A0A1R3XYD1	No	virulence, detoxification, adaptation			A0A1R3XYD1				IPR019239	Q7U0M5					Rv1113		Rv1113			
NC_002945.3	Mycobrowser_v4	CDS	912566	913513	.	+	0	Mb0842	mshd		gcn5-related n-acetyltransferase, mshd	Mb0842, -, len: 315 aa. Equivalent to Rv0819, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 315 aa overlap). Conserved hypothetical protein, equivalent to U2266N|U15182|MLU15182_24 HYPOTHETICAL PROTEIN from Mycobacterium leprae (312 aa), FASTA scores: opt: 1540,E(): 0, (75.2% identity in 314 aa overlap). Also highly similar to CAB88484.1|AL353816 putative acetyltransferase from Streptomyces coelicolor (309 aa).	X2BFZ8,Q7U173,Q7U173	No	intermediary metabolism and respiration			Q7U173					X2BFZ8,Q7U173					Rv0819		Rv0819			
NC_002945.3	Mycobrowser_v4	CDS	913556	914332	.	+	0	Mb0843	phoT		PROBABLE PHOSPHATE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PHOT	Mb0843, phoT, len: 258 aa. Equivalent to Rv0820,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 258 aa overlap). Probable phoT,phosphate-transport ATP-binding protein ABC transporter (see citation below), equivalent to PhoT|MLU15182_28|U15182 phosphate transport system ABC transporter from Mycobacterium leprae (258 aa), FASTA scores: opt: 1556, E(): 0, (91.5% identity in 258 aa overlap). Also highly similar to others e.g. CAB88472.1|AL353816 phosphate ABC transport system ATP-binding protein from Streptomyces coelicolor (258 aa); etc. Note that also highly similar to many PstB proteins e.g. AAC15686.1|AF045938|PstB putative ABC transporter nucleotide binding subunit from Mycobacterium smegmatis (258 aa). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	X2BG54,Q7U172,Q7U172	No	cell wall and cell processes			Q7U172					X2BG54,Q7U172					Rv0820		Rv0820			
NC_002945.3	Mycobrowser_v4	CDS	914388	915029	.	-	0	Mb0844c	phoY2		PROBABLE PHOSPHATE-TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PHOY2	Mb0844c, phoY2, len: 213 aa. Equivalent to Rv0821c,len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Probable phoY2,phosphate-transport system regulatory protein, highly similar to PhoY|MLU15182_29|U15182 phosphate transport system regulator from Mycobacterium leprae (222 aa), FASTA scores: opt: 1268, E(): 0, (93.0% identity in 213 aa overlap). Also similar to others e.g. NP_384620.1|NC_003047 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Sinorhizobium meliloti (237 aa); etc. Also highly similar to MTCI418A.03c|Z96070|PhoY1 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 937, E(): 0, (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY. TBparse score is 0.910.	X2BG89,P65721,P65721	No				P65721					X2BG89,P65721										
NC_002945.3	Mycobrowser_v4	CDS	1751151	1751555	.	+	0	Mb1587	vapc11		possible toxin vapc11	Mb1587, -, len: 134 aa. Equivalent to Rv1561, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 134 aa overlap). Conserved hypothetical protein, similar to others from Mycobacterium tuberculosis e.g. Q10847|Rv2010|MTCY39.07c (132 aa), FASTA scores: (37.0% identity in 127 aa overlap); and O06566|Rv1114|MTCY22G8.03 (124 aa).	X2BIQ3,P64880,P64880	No	virulence, detoxification, adaptation			P64880					X2BIQ3,P64880					Rv1561		Rv1561			
NC_002945.3	Mycobrowser_v4	CDS	918564	919580	.	-	0	Mb0847c	desA1		PROBABLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA1 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) (PROTEIN DES)	Mb0847c, desA1, len: 338 aa. Equivalent to Rv0824c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 338 aa overlap). Probable desA1 (alternate gene name: des), acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.19.2) (see first citation below), equivalent to U15182|MLU15182_32 acyl-[ACP] desaturase from Mycobacterium leprae (338 aa),FASTA scores: opt: 1880, E(): 0, (79.9% identity in 338 aa overlap); and highly similar in part to fragment CAB96061.1|AJ250019 Steroyl-ACP-desaturase from Mycobacterium avium subsp. paratuberculosis (93 aa). Also similar to other fatty acid desaturases e.g. T35035 probable acyl-[acyl-carrier protein] desaturase from Streptomyces coelicolor (328 aa); Q40731|STAD_ORYSA ACYL-[ACYL-CARRIER PROTEIN] DESATURASE PRECURSOR from Oryza sativa (Rice) (390 aa); etc. Also highly similar to desA2|Rv1094 from Mycobacterium tuberculosis (275 aa). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. BELONGS TO THE FATTY ACID DESATURASE FAMILY. COFACTOR: FERREDOXIN, FERREDOXIN NADPH REDUCTASE,AND NADPH.	Q7U169,A0A1R3XWJ1	No				A0A1R3XWJ1				IPR005067,IPR009078,IPR012348	Q7U169										
NC_002945.3	Mycobrowser_v4	CDS	925781	926194	.	+	0	Mb0855	PE_PGRS12		pe-pgrs family protein pe_pgrs12	Mb0855, PE_PGRS12, len: 137 aa. Equivalent to Rv0832, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 137 aa overlap). Member of the Mycobacterium tuberculosis PE family, possibly PGRS subfamily of gly-rich proteins, highly similar to many others e.g. MTCY1A11.25c|Z78020 (498 aa), FASTA scores: opt: 529, E(): 5.2e-22, (61.8% identity in 136 aa overlap); etc. Appears to have incurred frameshift as next ORF should be continuation; sequence has been checked but no error found.	Q7U161,A0A1R3XWM1	No				A0A1R3XWM1				IPR000084	Q7U161										
NC_002945.3	Mycobrowser_v4	CDS	921571	921963	.	-	0	Mb0850c	kmtr		metal sensor transcriptional regulator kmtr (arsr-smtb family)	Mb0850c, -, len: 130 aa. Equivalent to Rv0827c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Probable transcriptional regulator, similar to many e.g. CAC42856.1|AL592292 putative regulatory protein from Streptomyces coelicolor (115 aa); NP_301626.1|NC_002677 putative ArsR-family transcriptional regulator from Mycobacterium leprae (140 aa); BSUB0011_75|O31844|Z99114 YOZA PROTEIN from Bacillus subtilis (107 aa), FASTA scores: opt: 208, E(): 3.2e-08, (35.5% identity in 93 aa overlap); etc. Also similar to MTCY27.22c|Z95208 from Mycobacterium tuberculosis (135 aa), FASTA scores: opt: 201, E(): 1.2e-07, (35.7% identity in 98 aa overlap). Contains probable helix-turn helix motif from aa 42-63 (Score 1300, +3.61 SD).	Q7U166,A0A1R3XWJ7	No	regulatory proteins			A0A1R3XWJ7				IPR001845,IPR011991	Q7U166					Rv0827c		Rv0827c			
NC_002945.3	Mycobrowser_v4	tRNA	924633	924705	.	-	0	lysT	lysT		tRNA-Lys	lysT, len: 73 nt. Equivalent to lysT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Lys, anticodon ttt.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	924829	924902	.	+	0	gluT	gluT		tRNA-Glu	gluT, len: 74 nt. Equivalent to gluT, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Glu, anticodon ttc.		No																			
NC_002945.3	Mycobrowser_v4	CDS	926191	928512	.	+	0	Mb0856	PE_PGRS13		pe-pgrs family protein pe_pgrs13	Mb0856, PE_PGRS13, len: 773 aa. Equivalent to Rv0833, len: 749 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, but lacking N-terminal domain (present in preceding ORF),possibly due to frameshift. Similar in part to many others e.g. MTCY28_25|Z95890 (914 aa), FASTA scores: opt: 2726,E(): 0, (60.1% identity in 776 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 84 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (773 aa versus 749 aa).	Q7U160,A0A1R3XWY6	No				A0A1R3XWY6					Q7U160										
NC_002945.3	Mycobrowser_v4	CDS	928739	931234	.	-	0	Mb0857c	PE_PGRS14		pe-pgrs family protein pe_pgrs14	Mb0857c, PE_PGRS14, len: 831 aa. Equivalent to Rv0834c, len: 882 aa, from Mycobacterium tuberculosis strain H37Rv. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many others e.g. MTCY493_4|Z95844 (1329 aa),FASTA scores: opt: 2577, E(): 0, (52.0% identity in 950 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 882 aa).	Q7U159,A0A1R3XWK0	No				A0A1R3XWK0				IPR000084	Q7U159										
NC_002945.3	Mycobrowser_v4	CDS	931702	932346	.	+	0	Mb0858	lpqQ		POSSIBLE LIPOPROTEIN LPQQ	Mb0858, lpqQ, len: 214 aa. Equivalent to Rv0835,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 214 aa overlap). Possible lpqQ,lipoprotein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U158,A0A1R3XWK8	No	cell wall and cell processes			A0A1R3XWK8				IPR026954	Q7U158					Rv0835		Rv0835			
NC_002945.3	Mycobrowser_v4	CDS	935469	936245	.	+	0	Mb0861	lpqR		PROBABLE CONSERVED LIPOPROTEIN LPQR	Mb0861, lpqR, len: 258 aa. Equivalent to Rv0838,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 258 aa overlap). Probable lpqR,conserved lipoprotein. Similar (except in N-terminus) to hypothetical proteins and D-alanyl-D-alanine dipeptidases e.g. NP_416005.1|NC_000913 hypothetical protein from Escherichia coli strain K12 (193 aa); NP_421076.1|NC_002696 D-alanyl-D-alanine dipeptidase from Caulobacter crescentus (212 aa); Q06241|VANX_ENTFC D-ALANYL-D-ALANINE DIPEPTIDASE from Enterococcus faecium (202 aa), FASTA scores: opt: 198, E(): 1.9e-05, (28.1% identity in 199 aa overlap); etc. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 6bp insertion (*-cggccc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa).	Q7U155,A0A1R3XWL7	No	cell wall and cell processes			A0A1R3XWL7				IPR000755,IPR009045	Q7U155					Rv0838		Rv0838			
NC_002945.3	Mycobrowser_v4	CDS	937212	938072	.	-	0	Mb0863c	pip		PROBABLE PROLINE IMINOPEPTIDASE PIP (PROLYL AMINOPEPTIDASE) (PAP)	Mb0863c, pip, len: 286 aa. Equivalent to Rv0840c,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible pip, proline iminopeptidase (EC 3.4.11.5), similar to many e.g. P46541|PIP_BACCO PROLINE IMINOPEPTIDASE from BACILLUS COAGULANS (288 aa), FASTA scores: opt: 657, E(): 0, (37.6% identity in 282 aa overlap); NP_386922.1|NC_003047 PUTATIVE PROLINE IMINOPEPTIDASE PROTEIN from Sinorhizobium meliloti (296 aa); etc. BELONGS TO PEPTIDASE FAMILY S33.	Q7U153,A0A1R3XYP0	No				A0A1R3XYP0				IPR002410,IPR005945	Q7U153										
NC_002945.3	Mycobrowser_v4	CDS	941211	941861	.	-	0	Mb0867c	narL		POSSIBLE NITRATE/NITRITE RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN NARL	Mb0867c, narL, len: 216 aa. Equivalent to Rv0844c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 216 aa overlap). Possible narL,nitrate/nitrite response regulator protein, similar to many e.g. CAB44989.1|AJ131854 NarL protein from Pseudomonas stutzeri (218 aa); CAA75536.1|Y15252 nitrate/nitrite regulatory protein from Pseudomonas aeruginosa (216 aa); PCC6803|D64005|SYCSLRG_24 NarL protein from Synechocystis sp. (209 aa), FASTA scores: opt: 438, E(): 1.5e-23, (34.6% identity in 208 aa overlap); etc. Also similar to unidentified regulator e.g. CAB76009.1|AL157916 putative two-component system response regulator from Streptomyces coelicolor (224 aa); etc. Contains probable helix-turn helix motif from aa 170-191 (Score 1124, +3.02 SD).	Q7U149,A0A1R3XWL1	No				A0A1R3XWL1				IPR000792,IPR001789,IPR011006,IPR011991,IPR016032	Q7U149										
NC_002945.3	Mycobrowser_v4	CDS	945693	946811	.	+	0	Mb0871	cysK2		POSSIBLE CYSTEINE SYNTHASE A CYSK2 (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE)	Mb0871, cysK2, len: 372 aa. Equivalent to Rv0848,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 372 aa overlap). Possible cysK2,cysteine synthase A (EC 4.2.99.8), but could be also a cysteine synthase B (EC 4.2.99.8) cysM2-product, similar to many e.g. NP_109408.1|NC_002682 cysteine synthase from Mesorhizobium loti (357 aa); Q44004|CYSM_ALCEU CYSTEINE SYNTHASE from Alcaligenes eutrophus strain CH34 (Ralstonia eutropha) (339 aa), FASTA scores: opt: 511, E(): 1.7e-25,(35.0% identity in 314 aa overlap); etc. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE. Note that previously known as cysM3.	Q7U145,A0A1R3XWM7	No				A0A1R3XWM7				IPR001926	Q7U145										
NC_002945.3	Mycobrowser_v4	CDS	949314	950150	.	+	0	Mb0875	fadD16		POSSIBLE FATTY-ACID-COA LIGASE FADD16 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb0875, fadD16, len: 278 aa. Equivalent to Rv0852,len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 278 aa overlap). Possible fadD16,fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to various CoA ligases e.g. P18163|LCFB_RAT LONG-CHAIN-FATTY-ACID--COA LIGASE from Rattus norvegicus (Rat) (699 aa); D49366|LEP4CCOALA_1 4-coumarate:CoA ligase from Lithospermum erythrorhizon (636 aa), FASTA scores: opt: 134, E(): 0.15, (26.8% identity in 213 aa overlap); orgp|L09229|HUMFACAL_1 long-chain acyl-coenzyme A from homo sapiens (human) (699 aa), FASTA score: (50.0% identity in 40 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.	Q7U141,A0A1R3XWN9	No				A0A1R3XWN9					Q7U141										
NC_002945.3	Mycobrowser_v4	CDS	950191	951873	.	-	0	Mb0876c	pdc		PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC	Mb0876c, pdc, len: 560 aa. Equivalent to Rv0853c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable pdc,pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-),equivalent to NP_302424.1|NC_002677 pyruvate (or indolepyruvate) decarboxylase from Mycobacterium leprae (569 aa). Also highly similar to others e.g. AAB06571.1|L80006 indolepyruvate decarboxylase from Pantoea agglomerans (550 aa); Q12629|DCPY_KLULA PYRUVATE DECARBOXYLASE (EC 4.1.1.1) from Kluyveromyces marxianus var. lactis (563 aa); P71323 INDOLEPYRUVATE DECARBOXYLASE (EC 4.1.1.74) from Enterobacter herbicola (550 aa), FASTA scores: opt: 1642, E(): 0, (48.1% identity in 547 aa overlap); P23234|DCIP_ENTCL INDOLE-3-PYRUVATE DECARBOXYLASE (INDOLEPYRUVATE DECARBOXYLASE) from Enterobacter cloacae (552 aa), FASTA scores: opt: 1596,E(): 0, (46.8% identity in 551 aa overlap); etc. Contains PS00187 Thiamine pyrophosphate enzymes signature and PS00017 ATP/GTP-binding site motif A (P-loop). COFACTOR: THIAMINE PYROPHOSPHATE.	X2BGC9,Q7U140,Q7U140	No				Q7U140					X2BGC9,Q7U140										
NC_002945.3	Mycobrowser_v4	CDS	952387	953466	.	+	0	Mb0878	far		PROBABLE FATTY-ACID-COA RACEMASE FAR	Mb0878, far, len: 359 aa. Equivalent to Rv0855,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable far, fatty acid-CoA racemase (EC 5.1.-.-), highly similar to CAB08122.1|Z94723 unknown protein from Mycobacterium leprae (253 aa) (C-terminus shorter). Also similar to many eukaryotic and bacteria racemases e.g. T35425 probable fatty acid CoA racemase from Streptomyces coelicolor (387 aa); P70473|AMAC_RAT ALPHA-METHYLACYL-COA RACEMASE (2-METHYLACYL-COA RACEMASE) (2-ARYLPROPIONYL-COA EPIMERASE) (EC 5.1.99.4) from Rattus norvegicus (Rat) (382 aa); NP_103687.1|NC_002678 probable fatty acid Co-A racemase from Mesorhizobium loti (389 aa); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv1143|MTCI65.10|MCR from Mycobacterium tuberculosis (360 aa), FASTA scores: opt: 1373, E(): 0, (56.8% identity in 359 aa overlap), Rv1866|MTCY359.07 (C-terminal half) (778 aa), Rv3272 (360 aa).	Q7U138,A0A1R3XWM8	No	lipid metabolism			A0A1R3XWM8				IPR003673,IPR023606	Q7U138					Rv0855		Rv0855			
NC_002945.3	Mycobrowser_v4	CDS	954481	955674	.	-	0	Mb0881c	dapc		probable n-succinyldiaminopimelate aminotransferase dapc (dap-at)	Mb0881c, -, len: 397 aa. Equivalent to Rv0858c,len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 397 aa overlap). Probable aminotransferase (EC 2.6.1.-), highly similar to others from Eukaryota and bacteria, especially aspartate aminotransferases (transaminases) (EC 2.6.1.1), e.g. NP_177890.1|NC_003070 putative aminotransferase from Arabidopsis thaliana (440 aa); NP_419555.1|NC_002696 aminotransferase class I from Caulobacter crescentus (385 aa); NP_415133.1|NC_000913|AE0001|ECAE000165_8 putative aminotransferase from Escherichia coli strain K12 (386 aa), FASTA scores: opt: 830, E(): 0, (38.0% identity in 389 aa overlap); X99521|TAX99521_1 aspartate aminotransferase from Thermus aquaticus (383 aa), FASTA scores: opt: 702, E(): 0, (34.9% identity in 393 aa overlap); etc. Also similar to other putative aminotransferases from Mycobacterium tuberculosis e.g. Rv2294, Rv3565, etc.	Q7U135,A0A1R3XWP0	No	intermediary metabolism and respiration			A0A1R3XWP0				IPR004839,IPR015421,IPR015422,IPR015424	Q7U135					Rv0858c		Rv0858c			
NC_002945.3	Mycobrowser_v4	CDS	955831	957042	.	+	0	Mb0882	fadA		POSSIBLE ACYL-COA THIOLASE FADA	Mb0882, fadA, len: 403 aa. Equivalent to Rv0859,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 403 aa overlap). Possible fadA,acyl-CoA thiolase (EC 2.3.1.-), equivalent to NP_302423.1|NC_002677 putative beta-ketoadipyl CoA thiolase from Mycobacterium leprae (403 aa). Also highly similar to acyl/acetyl-CoA thiolases and beta-ketoadipyl CoA thiolases, e.g. T35428 probable acetyl CoA acetyltransferase (thiolase) from Streptomyces coelicolor (404 aa); NP_250427.1|NC_002516 probable acyl-CoA thiolase from Pseudomonas aeruginosa (401 aa); NP_106253.1|NC_002678 probable acyl-CoA thiolase from Mesorhizobium loti (402 aa); NP_248919.1|NC_002516|PcaF beta-ketoadipyl CoA thiolase PcaF from Pseudomonas aeruginosa (401 aa); etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiolases signature 2 and PS00099 Thiolases active site.	Q7U134,A0A1R3XWM6	No	lipid metabolism			A0A1R3XWM6				IPR002155,IPR016038,IPR016039,IPR020610,IPR020613,IPR020615,IPR020616,IPR020617	Q7U134					Rv0859		Rv0859			
NC_002945.3	Mycobrowser_v4	CDS	957047	959209	.	+	0	Mb0883	fadB		PROBABLE FATTY OXIDATION PROTEIN FADB	Mb0883, fadB, len: 720 aa. Equivalent to Rv0860,len: 720 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 720 aa overlap). Probable fadB, fatty oxidation protein, equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Also highly similar to others and various proteins involved in fatty acid metabolism, e.g. T35429 probable fatty oxidation protein from Streptomyces coelicolor (733 aa); NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (714 aa); NP_418895.1|NC_002696 fatty oxidation complex alpha subunit from Caulobacter crescentus (709 aa); P40939|ECHA_HUMAN TRIFUNCTIONAL ENZYME ALPHA SUBUNIT [INCLUDES: LONG-CHAIN ENOYL-COA HYDRATASE (EC 4.2.1.17); LONG CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (EC 1.1.1.35)] from Homo sapiens (763 aa), FASTA scores: opt: 1176, E(): 0, (32.4% identity in 722 aa overlap); P21177|FADB_ECOLI FATTY OXIDATION COMPLEX ALPHA SUBUNIT [INCLUDES: ENOYL-COA HYDRATASE (EC 4.2.1.17); DELTA(3)-CIS-DELTA(2)-TRANS-ENOYL-COA ISOMERASE (EC 5.3.3.8); 3-HYDROXYACYL-COA DEHYDROGENASE (EC 1.1.1.35); 3-HYDROXYBUTYRYL-COA EPIMERASE (EC 5.1.2.3)] from Escherichia coli strain K12 (729 aa), FASTA scores: opt: 873, E(): 0, (33.6% identity in 693 aa overlap); etc.	Q7U133,A0A1R3XYQ9	No	lipid metabolism			A0A1R3XYQ9				IPR001753,IPR006108,IPR006176,IPR008927,IPR013328,IPR016040	Q7U133					Rv0860		Rv0860			
NC_002945.3	Mycobrowser_v4	CDS	959277	960905	.	-	0	Mb0884c	ercc3		dna helicase ercc3	Mb0884c, -, len: 542 aa. Equivalent to Rv0861c,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 542 aa overlap). Probable DNA helicase (EC 3.6.1.-), equivalent to NP_302420.1|NC_002677 probable DNA helicase from Mycobacterium leprae (549 aa). Also highly similar to others (shorter than several eukaryotic enzymes) e.g. NP_218820.1|NC_000919|AE001217|AE0 01217_6 putative DNA repair helicase from Treponema pallidum (606 aa), FASTA scores: opt: 1275, E(): 0, (47.5% identity in 592 aa overlap); Q00578|RA25_YEAST DNA REPAIR HELICASE from Saccharomyces cerevisiae (843 aa), FASTA scores: opt: 777, E(): 0, (30.4% identity in 605 aa overlap); P49135|XPB_MOUSE DNA-REPAIR PROTEIN COMPLEMENTING XP-B CELLS from Mus musculus (Mouse) (783 aa), FASTA scores: opt: 761, E(): 0, (36.3% identity in 375 aa overlap); etc. SEEMS TO BELONG TO THE HELICASE FAMILY.	Q7U132,A0A1R3XXL8	No	information pathways			A0A1R3XXL8				IPR001161,IPR001650,IPR006935,IPR014001,IPR027417	Q7U132					Rv0861c		Rv0861c			
NC_002945.3	Mycobrowser_v4	CDS	963665	964093	.	+	0	Mb0888	moaC2		probable molybdenum cofactor biosynthesis protein c 2 moac2	Mb0888, moaC2, len: 142 aa. Similar to Rv0864, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Probable moaC2,molybdopterin cofactor biosynthesis protein, highly similar to others e.g. CAB59676.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (170 aa); NP_418834.1|NC_002696 molybdenum cofactor biosynthesis protein C from Caulobacter crescentus (186 aa); Y10817|ANY10817_3|T44852 molybdopterin co-factor synthesis protein moaC from Arthrobacter nicotinovorans plasmid pAO1 (169 aa), FASTA scores: opt: 491, E(): 2.4e-29, (51.0% identity in 151 aa overlap); etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 491, E(): 2.4e-29, (54.9% identity in 153 aa overlap); and O53376|Rv3324c|MOAC3|MTV016.24c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C3 (177 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	X2BG23,P0A5K7,P0A5K7	No				P0A5K7					X2BG23,P0A5K7										
NC_002945.3	Mycobrowser_v4	CDS	964090	964572	.	+	0	Mb0889	mog		probable molybdopterin biosynthesis mog protein	Mb0889, mog, len: 160 aa. Equivalent to Rv0865,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Probable mog,molybdopterin biosynthesis MOG protein, highly similar or similar to other molybdenum cofactor biosynthesis proteins e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa); CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa); P44645|MOG_HAEIN|MOGA|HI0336 MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Haemophilus influenzae (197 aa), FASTA scores: opt: 306, E(): 9e-13,(39.6% identity in 139 aa overlap); P28694|MOG_ECOLI MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Escherichia coli (195 aa), FASTA scores: opt: 265, E(): 3.6e-10, (34.2 identity in 146 aa overlap); etc. Also highly similar to Rv0984|MTV044.12|MOAB2 POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis (181 aa).	Q7U129,A0A1R3XWN7	No	intermediary metabolism and respiration			A0A1R3XWN7				IPR001453,IPR020817	Q7U129					Rv0865		Rv0865			
NC_002945.3	Mycobrowser_v4	CDS	964569	964994	.	+	0	Mb0890	moaE2		probable molybdenum cofactor biosynthesis protein e2 moae2 (molybdopterin converting factor large subunit) (molybdopterin [mpt] converting factor, subunit 2)	Mb0890, moaE2, len: 141 aa. Equivalent to Rv0866,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Probable moaE2,molybdopterin converting factor E (molybdopterin converting factor (subunit 2)), similar to others e.g. Y10817|ANY10817_4|T44853 molybdopterin biosynthesis protein E chain from Arthrobacter nicotinovorans plasmid pAO1 (155 aa), FASTA scores: opt: 460, E(): 3.5e-27, (49.3 identity in 146 aa overlap); CAC01331.1|AL390968 moaE-like protein from Streptomyces coelicolor (152 aa); NP_389313.1|NC_000964 molybdopterin converting factor (subunit 2) from Bacillus subtilis (157 aa); etc. Also highly similar to Rv3119|MOAE1|Z95150|MTCY164_30 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 321, E(): 5.9e-17, (40.9% identity in 132 aa overlap); and O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa).	Q7TTR9,A0A1R3XWM2	No				A0A1R3XWM2				IPR003448	Q7TTR9										
NC_002945.3	Mycobrowser_v4	CDS	965012	965995	.	-	0	Mb0891c	rpfA		POSSIBLE RESUSCITATION-PROMOTING FACTOR RPFA	Mb0891c, rpfA, len: 327 aa. Equivalent to Rv0867c,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(). Possible rpfA, resuscitation-promoting factor (see citation below). N-terminus highly similar to N-terminal part (1-125 aa) of Z99494|MLCB57_3|NP_302417.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (174 aa), FASTA scores: opt: 785, E(): 1.8e-18, (63.0% identity in 200 aa overlap); and highly similar to C-terminus of NP_301299.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (375 aa); and middle part of NP_302360.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (157 aa). N-terminus also highly similar in part of three secreted proteins from Streptomyces coelicolor e.g. CAC09538.1|AL442120 putative secreted protein (244 aa). Regions highly similar to CAB76321.1|AL158060 putative membrane protein from Streptomyces coelicolor (121 aa); and middle part of CAB09664.1|Z96935 rpf from Micrococcus luteus (220 aa). Also highly similar in part to four resuscitation-promoting factors from Mycobacterium tuberculosis: Rv2450 (172 aa), Rv1009 (362 aa), Rv1884c (176 aa), and Rv2389c (154 aa). Contains a probable secretory signal sequence in N-terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (327 aa versus 407 aa).	Q7U128,A0A1R3XWP1	No				A0A1R3XWP1				IPR010618,IPR023346	Q7U128										
NC_002945.3	Mycobrowser_v4	CDS	966443	966721	.	-	0	Mb0892c	moaD2		probable molybdenum cofactor biosynthesis protein d 2 moad2 (molybdopterin converting factor small subunit) (molybdopterin [mpt] converting factor, subunit 1)	Mb0892c, moaD2, len: 92 aa. Equivalent to Rv0868c,len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Probable moaD2,molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to CAB88494.1|AL353816 putative molybdopterin converting factor from Streptomyces coelicolor (84 aa); and weakly similar to others MoaD proteins e.g. Z99111|BSUB0008_103 from Bacillus subtilis (77 aa), FASTA scores: opt: 86,E(): 2.8, (22.9% identity in 83 aa overlap); etc. Also some similarity with Rv3112|MOAD1|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 113, E(): 0.024, (31.3% identity in 83 aa overlap).	Q7TTR8,A0A1R3XWP9	No				A0A1R3XWP9				IPR003749,IPR012675,IPR016155	Q7TTR8										
NC_002945.3	Mycobrowser_v4	CDS	966725	967807	.	-	0	Mb0893c	moaA2		probable molybdenum cofactor biosynthesis protein a2 moaa2	Mb0893c, moaA2, len: 360 aa. Equivalent to Rv0869c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 360 aa overlap). Probable moaA2,molybdenum cofactor biosynthesis protein, highly similar to others e.g. CAB59437.1|AL132644|SCI8_6 molybdenum cofactor biosynthesis protein A from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1336, E(): 0,(61.7% identity in 332 aa overlap); S57490|X78980|ANMOAA_1 molybdopterin cofactor synthesis protein from Arthrobacter nicotinovorans (fragment) (374 aa), FASTA scores: opt: 1059, E(): 0, (49.9% identity in 369 aa overlap); Q44118|MOAA_ARTNI PROBABLE MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A from Arthrobacter nicotinovorans plasmid pAO1 (355 aa); etc. Also similar to Rv3109|MTCY164.19|Z95150|MOAA1 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 657, E(): 0,(36.6% identity in 309 aa overlap). BELONGS TO THE MOAA / NIFB / PQQE FAMILY.	X2BG27,P65385,P65385	No				P65385					X2BG27,P65385										
NC_002945.3	Mycobrowser_v4	CDS	968358	968765	.	+	0	Mb0895	cspB		PROBABLE COLD SHOCK-LIKE PROTEIN B CSPB	Mb0895, cspB, len: 135 aa. Equivalent to Rv0871,len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Probable cspB, cold shock-like protein B, equivalent to Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from Mycobacterium leprae (136 aa), FASTA scores: opt: 787,E(): 0, (86.0% identity in 136 aa overlap). Also highly similar (but often longer than) to others e.g. CAB93399.1|AL357524 cold shock protein B from Streptomyces coelicolor (127 aa); Q45099|CSPD_BACCE COLD SHOCK-LIKE PROTEIN CSPD from Bacillus cereus (66 aa); Y101 81|LLCSPB_1 cold shock protein from Lactococcus lactis (66 aa), FASTA scores: opt: 220, E(): 2.5e-07, (48.3% identity in 60 aa overlap); etc. SEEMS TO BELONG TO THE COLD-SHOCK DOMAIN (CSD) FAMILY.	Q7U126,A0A1R3XXM9	No	virulence, detoxification, adaptation			A0A1R3XXM9				IPR002059,IPR011129,IPR012340	Q7U126					Rv0871		Rv0871			
NC_002945.3	Mycobrowser_v4	CDS	968884	970710	.	-	0	Mb0896c	PE_PGRS15		pe-pgrs family protein pe_pgrs15	Mb0896c, PE_PGRS15, len: 608 aa. Equivalent to Rv0872c, len: 606 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 606 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see first citation below),similar to many e.g. MTCY24A1.04c|Z95207 (615 aa), FASTA scores: opt: 2636, E(): 0, (64.6% identity in 619 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp in-frame deletion and a 9 bp in-frame insertion leads to a lightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (608 aa versus 606 aa).	Q7U125,A0A1R3XWQ7	No				A0A1R3XWQ7				IPR000084	Q7U125										
NC_002945.3	Mycobrowser_v4	CDS	970971	972923	.	+	0	Mb0897	fadE10		PROBABLE ACYL-COA DEHYDROGENASE FADE10	Mb0897, fadE10, len: 650 aa. Equivalent to Rv0873,len: 650 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 650 aa overlap). Probable fadE10,acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB91129.1|AL355913 putative acyl CoA dehydrogenase from Streptomyces coelicolor (658 aa); P50544|ACDV_MOUSE ACYL-COA DEHYDROGENASE from Mus musculus (656 aa); D30647|RATVLCAD_1 very-long-chain Acyl-CoA dehydrogenase from Rattus norvegicus (655 aa), FASTA scores: opt: 675, E(): 0, (33.9% identity in 380 aa overlap); etc.	X2BGE3,P63430,P63430	No				P63430					X2BGE3,P63430										
NC_002945.3	Mycobrowser_v4	CDS	977352	978668	.	-	0	Mb0902c	PPE13		ppe family protein ppe13	Mb0902c, PPE13, len: 438 aa. Equivalent to Rv0878c,len: 443 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. P4261|YHS6_MYCTU (517 aa), FASTA scores: opt: 1044, E(): 0, (47.4% identity in 397 aa overlap); MTV014_3, MTCI65_2, MTCY98_24, MTCY3C7_23, MTCY48_17,MTV004_5, MTV004_3, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (a-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa).	Q7U123,A0A1R3XWQ8	No				A0A1R3XWQ8				IPR000030,IPR002989	Q7U123										
NC_002945.3	Mycobrowser_v4	CDS	981889	983019	.	-	0	Mb0908c	serC		POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC (PSAT)	Mb0908c, serC, len: 376 aa. Equivalent to Rv0884c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible serC,phosphoserine aminotransferase (EC 2.6.1.52), equivalent to MLCB57_17 putative phosphoserine aminotransferase from Mycobacterium leprae (376 aa), FASTA scores: E(): 0, (87.5 identity in 376 aa overlap). Also highly similar to CAC08322.1|AL392149 putative aminotransferase from Streptomyces coelicolor (363 aa); and similar to other phosphoserine aminotransferases e.g. NP_386837.1|NC_003047 PUTATIVE PHOSPHOSERINE AMINOTRANSFERASE PROTEIN from Sinorhizobium meliloti (392 aa); P52878|SERC_METBA PHOSPHOSERINE AMINOTRANSFERASE from Methanosarcina barkeri (370 aa); P10658|SERC_RABIT|RABEPIP_1 PHOSPHOSERINE AMINOTRANSFERASE from Rabbit (370 aa), FASTA scores: opt: 271, E(): 3.5e-11, (24.5% identity in 368 aa overlap); etc. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE.	X2BG34,P63515,P63515	No				P63515					X2BG34,P63515										
NC_002945.3	Mycobrowser_v4	CDS	1240981	1241355	.	+	0	Mb1144	vapc32		possible toxin vapc32. contains pin domain.	Mb1144, -, len: 124 aa. Equivalent to Rv1114, len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Conserved hypothetical protein, slight similarity to Mycobacterium tuberculosis hypothetical proteins MTCY159.08c (33.0% identity in 115 aa overlap); Rv1561 and Rv2010.	Q7U0M4,A0A1R3XXF6	No	virulence, detoxification, adaptation			A0A1R3XXF6				IPR002716,IPR022907	Q7U0M4					Rv1114		Rv1114			
NC_002945.3	Mycobrowser_v4	CDS	984268	985995	.	+	0	Mb0910	fprB		PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	Mb0910, fprB, len: 575 aa. Equivalent to Rv0886,len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 575 aa overlap). Probable fprB,ferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin oxidoreductase) (EC 1.18.1.2), equivalent to O3306|MLCB57_19 FERREDOXIN/FERREDOXIN--NADP REDUCTASE from Mycobacterium leprae (555 aa), FASTA scores: E(): 0, (76.6 identity in 560 aa overlap). Also highly similar or similar to others e.g. NP_294219.1|NC_001263 putative ferredoxin/ferredoxin--NADP reductase from Deinococcus radiodurans (479 aa) (N-terminus shorter); P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from homo sapiens (497 aa), FASTA scores: opt: 624, E(): 3e-30,(39.7% identity in 484 aa overlap); P08165|ADRO_BOVIN NADPH:ADRENODOXIN OXIDOREDUCTASE from Bos taurus (492 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv3106, Rv3858c, etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.	X2BGE5,P65529,P65529	No	intermediary metabolism and respiration			P65529					X2BGE5,P65529					Rv0886		Rv0886			
NC_002945.3	Mycobrowser_v4	CDS	989205	990326	.	-	0	Mb0913c	citA		PROBABLE CITRATE SYNTHASE II CITA	Mb0913c, citA, len: 373 aa. Equivalent to Rv0889c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 373 aa overlap). Probable citA (alternate gene name: gltA), citrate synthase 2 (EC 4.1.3.7), highly similar to others e.g. CAB95899.1|AL359988 putative citrate synthase from Streptomyces coelicolor (387 aa); P39119|CISY_BACSU citrate synthase II from Bacillus subtilis (366 aa), FASTA scores: opt: 586, E(): 5.8e-30, (33.8% identity in 367 aa overlap); etc. Also similar to Rv0896|MTCY31.24 from Mycobacterium tuberculosis (29.2% identity in 274 aa overlap) and Rv1131. Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY.	X2BG39,P63778,P63778	No				P63778					X2BG39,P63778										
NC_002945.3	Mycobrowser_v4	CDS	2078001	2078264	.	-	0	Mb1870c	vapb13		possible antitoxin vapb13	Mb1870c, -, len: 87 aa. Equivalent to Rv1839c, len: 87 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 87 aa overlap). Conserved hypothetical protein. Some similarity to G217008 CHO-ORF1 (279 aa),FASTA scores: opt: 86, E(): 13, (38.7% identity in 62 aa overlap).	Q7TZG5,A0A1R3Y1M5	No	virulence, detoxification, adaptation			A0A1R3Y1M5					Q7TZG5					Rv1839c		Rv1839c			
NC_002945.3	Mycobrowser_v4	CDS	999937	1001232	.	+	0	Mb0920	gltA2		PROBABLE CITRATE SYNTHASE I GLTA2	Mb0920, gltA2, len: 431 aa. Equivalent to Rv0896,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8%% identity in 431 aa overlap). Probable gltA2,citrate synthase 1 (EC 4.1.3.7), highly similar to O33066|NP_302405.1|NC_002677 citrate synthase 1 from Mycobacterium leprae (431 aa), FASTA scores: E(): 0, (91.0 identity in 431 aa overlap); and AAF04133.1|AF191033_1|AF191033 citrate synthase from Mycobacterium smegmatis (441 aa). Also highly similar to others e.g. AAF14286.1|AF181118_1|AF181118 citrate synthase from Streptomyces coelicolor (429 aa); P42457|CISY_CORGL CITRATE SYNTHASE from Corynebacterium glutamicum (437 aa), FASTA scores: opt: 1847, E(): 0,(63.0% identity in 433 aa overlap); etc. Also similar to two other Mycobacterium tuberculosis citrate synthases,Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (29.2% identity in 274 aa overlap) and Rv1131|MTCY22G8.20|gltA1 (393 aa). Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY.	Q7U122,A0A1R3XWQ4	No				A0A1R3XWQ4				IPR002020,IPR010953,IPR016141,IPR016142,IPR016143,IPR019810,IPR024176	Q7U122										
NC_002945.3	Mycobrowser_v4	CDS	1003277	1004257	.	+	0	Mb0923	ompA		outer membrane protein a ompa	Mb0923, ompA, len: 326 aa. Equivalent to Rv0899,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable ompA, outer membrane protein A, C-terminal region similar to C-terminus of many members of the OMPA family of outer membrane proteins e.g. NP_458280.1|NC_003198 putative outer membrane protein from Salmonella enterica subsp. enterica serovar Typhi (220); NP_418008.1|NC_000913 putative outer membrane protein from Escherichia coli strain K12 (219 aa), FASTA scores: opt: 296, E(): 2.2e-11,(45.3% identity in 117 aa overlap); NP_231844.1|NC_002505 outer membrane protein OmpA from Vibrio cholerae (321 aa); Q05146|OMPA_BORAV OUTER MEMBRANE PROTEIN A PRECURSOR from Bordetella avium (194 aa); etc. A signal peptide sequence probably exists at the N-terminus. Contains PS00044 Bacterial regulatory proteins, lysR family signature. BELONGS TO THE OMPA FAMILY.	X2BG45,P65594,P65594	No	cell wall and cell processes			P65594					X2BG45,P65594					Rv0899		Rv0899			
NC_002945.3	Mycobrowser_v4	CDS	1216207	1216512	.	+	0	Mb1118	PE10		pe family protein pe10	Mb1118, PE10, len: 101 aa. Equivalent to Rv1089,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 101 aa overlap). Member of the Mycobacterium tuberculosis PE family of glycine-rich proteins. Partial ORF that appears to be frameshifted,continuation of Rv1088|MTV017.41. Sequence has been checked and appears correct. Similar to Z95555|MTCY06F7_4 Mycobacterium tuberculosis cosmid (401 aa), FASTA scores: opt: 126, E(): 2, (29.6% identity in 125 aa overlap).	Q7U0P4,A0A1R3XXB4	No	PE/PPE			A0A1R3XXB4				IPR008965	Q7U0P4					Rv1089		Rv1089			
NC_002945.3	Mycobrowser_v4	CDS	1004966	1006306	.	-	0	Mb0926c	prrB		TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	Mb0926c, prrB, len: 446 aa. Equivalent to Rv0902c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 446 aa overlap). prrB, two-component sensor histidine kinase (EC 2.7.3.-) (see citations below), transmembrane protein, equivalent to MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase from Mycobacterium leprae (446 aa); and similar at C-termini to NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa). C-terminus also similar to the C-termini of many sensor-like histidine kinase proteins e.g. P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor protein from Escherichia coli strain K12 (457 aa), FASTA scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa overlap); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (483 aa); CAB82845.1|AJ277081 putative histidine kinase from Amycolatopsis mediterranei (472 aa); etc. Also similar in part to Mycobacterium tuberculosis proteins Rv3764c (475 aa); and Rv0982 (504 aa). Thought to be induced at phagocytosis (see second citation below).	X2BGH8,P0A5Z9,P0A5Z9	No				P0A5Z9					X2BGH8,P0A5Z9										
NC_002945.3	Mycobrowser_v4	CDS	1006317	1007027	.	-	0	Mb0927c	prrA		TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA	Mb0927c, prrA, len: 236 aa. Equivalent to Rv0903c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). prrA, two-component response regulator (see citations below), equivalent to Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component response regulator from Mycobacterium leprae (233 aa),FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa overlap); and similar to T45446 probable two-component response regulator from Mycobacterium leprae (253 aa). Also similar to many sensor-like histidine kinase proteins e.g. CAB88489.1|AL353816 putative two-component systen response regulator from Streptomyces coelicolor (248 aa); AAG36759.1|AF119221_1 |AF119221 response regulator from Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM transcriptional activator protein COPR from Pseudomonas syringae (pv. tomato) (227 aa), FASTA scores: opt: 600,E(): 0, (44.4% identity in 225 aa overlap); etc. Also similar to Rv0981 from Mycobacterium tuberculosis (230 aa), Rv3765c (234 aa), phoP (247 aa), etc. Thought to be induced at phagocytosis (see second citation below).	X2BGG9,P0A5Z7,P0A5Z7	No				P0A5Z7					X2BGG9,P0A5Z7										
NC_002945.3	Mycobrowser_v4	CDS	1242374	1242559	.	+	0	Mb1146	Mb1146		HYPOTHETICAL PROTEIN	Mb1146, -, len: 61 aa. Equivalent to Rv1116, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 61 aa overlap). Hypothetical unknown protein.	Q7U0M2,A0A1R3XXE7	No	conserved hypotheticals			A0A1R3XXE7					Q7U0M2					Rv1116		Rv1116			
NC_002945.3	Mycobrowser_v4	CDS	1007158	1008645	.	-	0	Mb0928c	accD3		PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE (SUBUNIT BETA) ACCD3 (ACCASE BETA CHAIN)	Mb0928c, accD3, len: 495 aa. Equivalent to Rv0904c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 495 aa overlap). Putative accD3,acetyl-CoA carboxylase carboxyl transferase, beta subunit (carboxyltransferase subunit of acetyl-CoA carboxylase) (EC 6.4.1.2), highly similar in part to AAA63045.1|U15184 zinc finger protein from Mycobacterium leprae (201 aa). Also highly similar to others e.g. CAC42827.1|Y17592 putative carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum (491 aa); CAB86110.1|AL163003 putative acetyl CoA carboxylase (alpha and beta subunits) from Streptomyces coelicolor (458 aa); Q54776|ACCD_SYNP7 ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Synechococcus sp. (305 aa); P12217|ACCD_MARPO ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Marchantia polymorpha (316 aa), FASTA scores: opt: 519, E():1.6e-24, (40.2% identity in 219 aa overlap); etc. Also similar to Rv3280, Rv2502c,etc from Mycobacterium tuberculosis. BELONGS TO THE ACCD/PCCB FAMILY.	X2BG50,P63406,P63406	No				P63406					X2BG50,P63406										
NC_002945.3	Mycobrowser_v4	CDS	1008672	1009403	.	+	0	Mb0929	echA6		POSSIBLE ENOYL-COA HYDRATASE ECHA6 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb0929, echA6, len: 243 aa. Equivalent to Rv0905,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 243 aa overlap). Possible echA6,enoyl-CoA hydratase (EC 4.2.1.17), highly similar to ML15184|U15184 enoyl-CoA hydratase from Mycobacterium leprae (247 aa), FASTA score: (85.8% identity in 247 aa overlap). Also similar to many e.g. NP_250320.1|NC_002516 probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa (261 aa); NP_415911.1|NC_000913 putative enzyme from Escherichia coli strain K12 (255 aa); P24162 ECHH_RHOCA|FADB1 enoyl-CoA hydratase homolog from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores: opt: 404, E():7.8e-21, (37.3% identity in 249 aa overlap); etc.	X2BGD6,P64015,P64015	No				P64015					X2BGD6,P64015										
NC_002945.3	Mycobrowser_v4	CDS	1012197	1014590	.	+	0	Mb0932	ctpE		PROBABLE METAL CATION TRANSPORTER ATPASE P-TYPE CTPE	Mb0932, ctpE, len: 797 aa. Equivalent to Rv0908,len: 797 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 797 aa overlap). Probable ctpE, metal cation-transporting ATPase P-type, transmembrane protein,E1-E2 family, highly similar to many e.g. AB93406.1|AL357524 putative integral membrane ATPase from Streptomyces coelicolor (802 aa); NP_346063.1|NC_003028 cation-transporting ATPase (E1-E2 family) from Streptococcus pneumoniae (778 aa); P37278|ATCL_SYNP7|PACL cation-transporting atpase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (926 aa), FASTA scores: opt: 257, E(): 4.8e-33, (27.7% identity in 905 aa overlap); etc. Contains E1-E2 ATPases phosphorylation site (PS00154). BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES).	X2BGH4,P0A505,P0A505	No	cell wall and cell processes			P0A505					X2BGH4,P0A505					Rv0908		Rv0908			
NC_002945.3	Mycobrowser_v4	tRNA	1025787	1025859	.	-	0	argT	argT		tRNA-Arg	argT, len: 73 nt. Equivalent to argT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon cct.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1020524	1021795	.	-	0	Mb0939c	PPE14		ppe family protein ppe14	Mb0939c, PPE14, len: 423 aa. Equivalent to Rv0915c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 423 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. Rv1807 from Mycobacterium tuberculosis (403 aa),FASTA scores: opt: 966, E(): 4.4e-30, (45.7% identity in 392 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.	Q7U114,A0A1R3XWT8	No				A0A1R3XWT8				IPR000030,IPR022171	Q7U114										
NC_002945.3	Mycobrowser_v4	CDS	1022553	1024334	.	+	0	Mb0941	betP		POSSIBLE GLYCINE BETAINE TRANSPORT INTEGRAL MEMBRANE PROTEIN BETP	Mb0941, betP, len: 593 aa. Equivalent to Rv0917,len: 593 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 593 aa overlap). Possible betP, glycine betaine transporter, integral membrane protein, highly similar to many transporters, mainly glycine betaine transporters, e.g. P54582|BETP_CORGL glycine betaine transporter from Corynebacterium glutamicum (Brevibacterium flavum) (595 aa), FASTA scores: opt: 1367,E(): 0, (42.7% identity in 504 aa overlap); T35264 probable BCCT family transporter from Streptomyces coelicolor (578 aa); NP_243511.1|NC_002570 glycine betaine transporter from Bacillus halodurans (504 aa); NP_439848.1|NC_000907 high-affinity choline transport protein (betT) from Haemophilus influenzae (669 aa); etc. SEEMS TO BELONG TO THE BCCT (TC 2.33) FAMILY OF TRANSPORTERS.	X2BGK1,P63696,P63696	No	cell wall and cell processes			P63696					X2BGK1,P63696					Rv0917		Rv0917			
NC_002945.3	Mycobrowser_v4	CDS	1031044	1033098	.	-	0	Mb0948c	mntH		conserved protein	Mb0948c, mntH, len: 685 aa. Similar to Rv0924c (mntH) and Rv0925c, len: 428 aa and 245 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 428 aa overlap and 93.2% identity in 237 aa overlap). mntH (alternative gene name: Nramp, Mramp), H+-dependent divalent cation-transport integral membrane protein (see citations below), equivalent to O69443|MNTH_MYCBO PROBABLE MANGANESE TRANSPORT PROTEIN MNTH (BRAMP) from Mycobacterium bovis (415 aa); and NP_302396.1|NC_002677 probable manganese transport protein from Mycobacterium leprae (426 aa). Also similar (but longer 51 aa in N-terminus) to AAA63075.1|U15184 SMF2 protein from Mycobacterium leprae (377 aa), FASTA scores: opt: 1780,E(): 0, (74.5% identity in 376 aa overlap). Also similar to many orthologues of the eukaryotic Nramp (natural resistance-associated macrophage protein), also known as mntH, e.g. NP_456951.1|NC_003198 manganese transport protein MntH from Salmonella enterica subsp. enterica serovar Typhi (413 aa); etc. BELONGS TO THE NRAMP FAMILY. And Conserved hypothetical protein, similar to AL132991|SCF55_19 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (197 aa), FASTA scores: opt: 459, E(): 1.2e-23,(39.3% identity in 201 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product.	X2BG74,O69443,O69443	No				O69443					X2BG74,O69443										
NC_002945.3	Mycobrowser_v4	CDS	1035368	1036480	.	+	0	Mb0951	pstS3		PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS3 (PBP-3) (PSTS3) (PHOS1)	Mb0951, pstS3, len: 370 aa. Equivalent to Rv0928,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 370 aa overlap). pstS3 (previously known as phoS2), phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to others from Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1 phosphate-binding protein 3 precursor (328 aa), FASTA scores: opt: 1772, E(): 0,(79.6% identity in 328 aa overlap); and highly similar to others e.g. AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa). Also highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (370 aa); and Rv0934|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (374 aa) from Mycobacterium tuberculosis (Mycobacterium tuberculosis seems to have three PstS-like proteins,others being Rv0932c and Rv0934c). Contains lipoprotein signature (PS00013) at N-terminus. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS.	X2BGL4,P0A5Y3,P0A5Y3	No				P0A5Y3					X2BGL4,P0A5Y3										
NC_002945.3	Mycobrowser_v4	CDS	1036493	1037467	.	+	0	Mb0952	pstC2		PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTC2	Mb0952, pstC2, len: 324 aa. Equivalent to Rv0929,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 324 aa overlap). pstC2,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_302394.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (319 aa); CAB88474.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (336 aa); NP_290359.1| NC_002655 high-affinity phosphate-specific transport system (cytoplasmic membrane component) from Escherichia coli strain O157:H7 (319 aa); etc. Also similar to Rv935|MTCY08D9.04c|PSTC1 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (338 aa). Contains binding-protein-dependent transport systems inner membrane component signature (PS00402).	X2BGK2,P0A631,P0A631	No				P0A631					X2BGK2,P0A631										
NC_002945.3	Mycobrowser_v4	CDS	1037464	1038378	.	+	0	Mb0953	pstA1		PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA1	Mb0953, pstA1, len: 304 aa. Equivalent to Rv0930,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Probable pstA1,phosphate-transport integral membrane ABC transporter (see citation below), highly similar to others e.g. NP_302393.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (304 aa); CAB88473.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (354 aa) (N-terminus longer); NP_312689.1|NC_002695 phosphate transport system permease protein PstA from Escherichia coli strain O157:H7 (296 aa); etc. Also similar to Rv0936|MTCY08D9.03c|PSTA2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa).	Q7U103,A0A1R3XWV3	No				A0A1R3XWV3				IPR000515,IPR005672	Q7U103										
NC_002945.3	Mycobrowser_v4	CDS	1038385	1039494	.	-	0	Mb0954c	pknDb		TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D PKNDb [SECOND PART](PROTEIN KINASE D) (STPK D)	Mb0954c, pknDb, len: 369 aa. Equivalent to 3' end of Rv0931c, len: 664 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 369 aa overlap). pknD (alternate gene name: mbk), transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citations below),equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa); and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 aa). Also highly similar to others, particularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa); NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa); etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase subdomain. Contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb.	Q7U102,A0A1R3XYY6	No				A0A1R3XYY6				IPR001258,IPR011042,IPR013017	Q7U102										
NC_002945.3	Mycobrowser_v4	CDS	1039505	1040380	.	-	0	Mb0955c	pknDa		TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D PKNDa [FIRST PART] (PROTEIN KINASE D) (STPK D)	Mb0955c, pknDa, len: 291 aa. Equivalent to 5' end of Rv0931c, len: 664 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 276 aa overlap). pknD (alternate gene name: mbk), transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citations below),equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa); and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 aa). Also highly similar to others, particularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa); NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa); etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase subdomain. Contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb.	Q79IB8,A0A1R3XXU1	No				A0A1R3XXU1				IPR000719,IPR008271,IPR011009,IPR017441	Q79IB8										
NC_002945.3	Mycobrowser_v4	CDS	1043766	1044782	.	+	0	Mb0960	pstC1		PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTC1	Mb0960, pstC1, len: 338 aa. Equivalent to Rv0935,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 338 aa overlap). pstC1,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_104768.1|NC_002678|pstC phosphate ABC transporter permease protein from Mesorhizobium loti (327 aa); NP_245372.1|NC_002663|PstC PstC protein from Pasteurella multocida (320 aa); P45191|PSTC_HAEIN PHOSPHATE TRANSPORT SYSTEM PERMEASE from Haemophilus influenza (315 aa), FASTA scores: opt: 667, E(): 0, (36.2% identity in 309 aa overlap); etc. Also similar to Rv0929|MTCY21C12.23|PSTC2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (324 aa), FASTA scores: opt: 487, E(): 4.1e-21, (32.3% identity in 303 aa overlap); and shows slight similarity to MTCY08D9.03c|PSTA2|Rv0936 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402).	X2BGK3,P0A629,P0A629	No				P0A629					X2BGK3,P0A629										
NC_002945.3	Mycobrowser_v4	CDS	1040402	1041514	.	-	0	Mb0956c	pstS2		PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS2 (PBP-2) (PSTS2)	Mb0956c, pstS2, len: 370 aa. Equivalent to Rv0932c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 370 aa overlap). pstS2,phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa); Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa),FASTA scores: opt: 1601, E(): 0, (64.5% identity in 372 aa overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa) (M. tuberculosis seems to have three PstS-like proteins, others being Rv0928 and Rv0934c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 460, E(): 2.7e-20, (31.2% identity in 375 aa overlap). Contains prokaryotic membrane lipoprotein lipid attachment site (PS00013) at N-terminus so the leader peptide of 22 aa is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. Appears to be co-transcribed with Rv0931c|pknD|mbk.	Q7U101,A0A1R3XWW7	No				A0A1R3XWW7				IPR005673,IPR024370	Q7U101										
NC_002945.3	Mycobrowser_v4	CDS	1041730	1041945	.	+	0	Mb0957	pstBa		PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBa [FIRST PART]	Mb0957, pstBa, len: 71 aa. Equivalent to the 5' end of Rv0933, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv (98.4% identity in 64 aa overlap). pstB,phosphate-transport ATP-binding protein ABC transporter (see citations below), thermostable ATPase, highly similar to others e.g. NP_348334.1|NC_003030 ATPase component of ABC-type phosphate transport system from Clostridium acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate ABC transporter ATP-binding protein (pstB) from Borrelia burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC transporter (ATP-binding protein) from Bacillus subtilis (269 aa), FASTA scores: opt: 762, E(): 0, (47.7% identity in 243 aa overlap); etc. Also similar to other M. tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC transporters family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium seem to have no influence on the functionality of this enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pstB into 2 parts, pstBa and pstBb.	Q7U100,Q7U0Z9,Q7U0Z9	No				Q7U0Z9				IPR027417	Q7U100,Q7U0Z9										
NC_002945.3	Mycobrowser_v4	CDS	1041920	1042561	.	+	0	Mb0958	pstBb		PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBb [SECOND PART]	Mb0958, pstBb, len: 213 aa. Equivalent to the 3' end of Rv0933, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 213 aa overlap). pstB, phosphate-transport ATP-binding protein ABC transporter (see citations below), thermostable ATPase, highly similar to others e.g. NP_348334.1|NC_003030 ATPase component of ABC-type phosphate transport system from Clostridium acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate ABC transporter ATP-binding protein (pstB) from Borrelia burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC transporter (ATP-binding protein) from Bacillus subtilis (269 aa),FASTA scores: opt: 762, E(): 0, (47.7% identity in 243 aa overlap); etc. Also similar to other M. tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC transporters family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium seem to have no influence on the functionality of this enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits pstB into 2 parts,pstBa and pstBb.	X2BG85,Q7U0Z9,Q7U0Z9	No				Q7U0Z9					X2BG85,Q7U0Z9										
NC_002945.3	Mycobrowser_v4	CDS	1042582	1043706	.	+	0	Mb0959	pstS1		PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS1 (PBP-1) (PSTS1)	Mb0959, pstS1, len: 374 aa. Equivalent to Rv0934,len: 374 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 374 aa overlap). pstS1 (previously known as phoS1 or phoS), phosphate-binding lipoprotein component of inorganic phosphate transport system (see first, fourth, fifth and sixth citations below), highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA scores: opt: 460, E(): 5.9e-19, (31.2% identity in 375 aa overlap); and Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 435, E():1.1e-17, (30.0% identity in 380 aa overlap) (Mycobacterium tuberculosis seems to have three PstS-like proteins, others being Rv0932c and Rv0928c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 2459, E(): 0, (100% identity in 374 aa overlap). Contains a prokaryotic membrane lipoprotein lipid attachment site (PS00013) at the N-terminus so the 23 aa leader peptide sequence is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS.	Q7U0Z8,A0A1R3XWV8	No				A0A1R3XWV8				IPR005673,IPR024370	Q7U0Z8										
NC_002945.3	Mycobrowser_v4	CDS	1044784	1045689	.	+	0	Mb0961	pstA2		PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA2	Mb0961, pstA2, len: 301 aa. Equivalent to Rv0936,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 301 aa overlap). pstA2,phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_442269.1|NC_000911|PstA phosphate transport system permease protein from Synechocystis sp. strain PCC 6803 (287 aa); NP_232473.1|NC_002506 phosphate ABC transporter permease protein from Vibrio cholerae (289 aa); P07654|PSTA_ECOLI PHOSPHATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (296 aa), FASTA scores: opt: 464, E(): 6.7e-24, (30.5% identity in 282 aa overlap); etc. Also similar to O86345|MTCY21C12.24|PSTA1|Rv0930 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (304 aa),FASTA scores: opt: 369, E(): 6.1e-15, (32.7% identity in 248 aa overlap). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402).	X2BGM5,P0A627,P0A627	No				P0A627					X2BGM5,P0A627										
NC_002945.3	Mycobrowser_v4	CDS	1045666	1046487	.	-	0	Mb0962c	mku		dna end-binding protein, mku	Mb0962c, -, len: 273 aa. Equivalent to Rv0937c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 273 aa overlap). Conserved hypothetical protein, highly similar to others e.g. SC6G9.24c|T35620|AL079356 hypothetical protein from Streptomyces coelicolor (365 aa), FASTA scores: opt: 648,E(): 0, (36.5% identity in 274 aa overlap); Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical proteins from Bacillus subtilis (311 aa), FASTA scores: opt: 623, E(): 1.1e-31, (33.9% identity in 274 aa overlap); O28548|AE000984|AF1726|NP_070554.1|NC_000917 conserved hypothetical protein from Archaeoglobus fulgidus (286 aa), FASTA scores: opt: 583, E(): 0, (36.6% identity in 262 aa overlap); etc.	Q7U0Z7,A0A1R3XWW4	No	information pathways			A0A1R3XWW4				IPR006164,IPR009187,IPR016194	Q7U0Z7					Rv0937c		Rv0937c			
NC_002945.3	Mycobrowser_v4	CDS	1046603	1048882	.	+	0	Mb0963	ligd		atp dependent dna ligase ligd (atp dependent polydeoxyribonucleotide synthase) (thermostable dna ligase) (atp dependent polynucleotide ligase) (sealase) (dna repair enzyme) (dna joinase)	Mb0963, -, len: 759 aa. Equivalent to Rv0938, len: 759 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 759 aa overlap). Possible ATP-dependent DNA ligase (EC 6.5.1.1), with its C-terminus similar to N-terminal parts of many ATP-dependent DNA ligases e.g. NP_250828.1|NC_002516 probable ATP-dependent DNA ligase from Pseudomonas aeruginosa (840 aa); NP_105436.1|NC_002678 ATP-dependent DNA ligase from Mesorhizobium loti (829 aa); CAB92891.1|AL356932 probable ATP-dependent DNA ligase from Streptomyces coelicolor (326 aa); etc. The N-terminal half shows similarity with hypothetical proteins from Mycobacterium tuberculosis Rv0269c and Rv3730c; and the C-terminal half with the DNA ligases Rv3731 and Rv3062.	X2BG90,P59971,P59971	No	information pathways			P59971					X2BG90,P59971					Rv0938		Rv0938			
NC_002945.3	Mycobrowser_v4	tRNA	1113962	1114034	.	+	0	alaV	alaV		tRNA-Ala	alaV, len: 73 nt. Equivalent to alaV, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon cgc.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1068000	1068647	.	+	0	Mb0981	purN		PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN (GART) (GAR TRANSFORMYLASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE)	Mb0981, purN, len: 215 aa. Equivalent to Rv0956,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Probable purN,5'-phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), equivalent to AAF05726.1|AF191543_1|AF191543|PurN phosphoribosylglycinamide formyltransferase from Mycobacterium avium subsp. paratuberculosis (209 aa); and AL035500|MLCL373_7 from Mycobacterium leprae (215 aa),FASTA score: (79.4% identity in 214 aa overlap). Also highly similar to others e.g. BAA89443.1|AB003159 from Corynebacterium ammoniagenes (199 aa); NP_241498.1|NC_002570 from Bacillus halodurans (188 aa); P08179|PUR3_ECOLI|B2500 from Escherichia coli strain K12 (212 aa), FASTA scores: opt: 380, E(): 2.4e-18, (36.6% identity in 183 aa overlap); C-terminus of P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 from Drosophila pseudoobscura (Fruit fly) (1364 aa); etc.	Q7U0Y9,A0A1R3XWY5	No	intermediary metabolism and respiration			A0A1R3XWY5				IPR002376,IPR004607	Q7U0Y9					Rv0956		Rv0956			
NC_002945.3	Mycobrowser_v4	CDS	1055491	1057152	.	-	0	Mb0971c	pgi		PROBABLE GLUCOSE-6-PHOSPHATE ISOMERASE PGI (GPI) (PHOSPHOGLUCOSE ISOMERASE) (PHOSPHOHEXOSE ISOMERASE) (PHI)	Mb0971c, pgi, len: 553 aa. Equivalent to Rv0946c,len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 553 aa overlap). Probable pgi,glucose-6-phosphate isomerase (EC 5.3.1.9), equivalent to NP_301236.1|NC_002677 glucose-6-phosphate isomerase from Mycobacterium leprae (554 aa); and P96803|G6PI_MYCSM GLUCOSE-6-PHOSPHATE ISOMERASE from Mycobacterium smegmatis (442 aa). Also highly similar to others e.g. T36015 glucose-6-phosphate isomerase from Streptomyces coelicolor (551 aa); P11537|G6PI_ECOLI|GPI glucose-6-phosphate isomerase from Escherichia coli strains K12 and O157:H7 (549 aa), FASTA scores: opt: 1779, E(): 0, (51.4% identity in 554 aa overlap); etc. Contains PS00765 Phosphoglucose isomerase signature 1, and PS00174 Phosphoglucose isomerase signature 2. BELONGS TO THE GPI FAMILY.	X2BGN2,P64193,P64193	No				P64193					X2BGN2,P64193										
NC_002945.3	Mycobrowser_v4	CDS	1058727	1061042	.	+	0	Mb0974	uvrD1		probable atp-dependent dna helicase ii uvrd1	Mb0974, uvrD1, len: 771 aa. Equivalent to Rv0949,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 771 aa overlap). Probable uvrD1, ATP dependent DNA helicase (EC 3.6.1.-), equivalent to P_301239.1|NC_002677 putative ATP-dependent DNA helicase from Mycobacterium leprae (778 aa). Also highly similar to others e.g. CAB92660.1|AL356832 from Streptomyces coelicolor (831 aa) (N-terminus longer); P56255|PCRA_BACST from Bacillus stearothermophilus (724 aa); Q10213|YAY5_SCHPO from Schizosaccharomyces pombe (Fission yeast) (887 aa), FASTA scores: opt: 927, E(): 0, (33.5% identity in 659 aa overlap); etc. Also similar to several other UvrD-like proteins in Mycobacterium tuberculosis e.g. Rv3201c, Rv3198c, Rv3202c. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. Note that previously known as uvrD.	X2BGI2,P0A5A4,P0A5A4	No				P0A5A4					X2BGI2,P0A5A4										
NC_002945.3	Mycobrowser_v4	CDS	1068644	1070215	.	+	0	Mb0982	purH		PROBABLE BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH: PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE (AICAR TRANSFORMYLASE) (5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE-4-CARBOXAMIDE FORMYLTRANSFERASE) + INOSINEMONOPHOSPHATE CYCLOHYDROLASE (IMP CYCLOHYDROLASE) (INOSINICASE) (IMP SYNTHETASE) (ATIC)	Mb0982, purH, len: 523 aa. Equivalent to Rv0957,len: 523 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 523 aa overlap). Probable purH,bifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase (EC 2.1.2.3) and inosine-monophosphate (IMP) cyclohydrolase (EC 3.5.4.10), equivalent to AL035500|MLCL373_8 putative phosphoribosylaminoimidazolecarboxamide formyltransferase from Mycobacterium leprae (527 aa), FASTA score: (88.1% identity in 520 aa overlap); and AF05727.1|AF191543_2|AF191543|PurH from Mycobacterium avium subsp. paratuberculosis (527 aa). Also highly similar to others e.g. CAB92677.1|AL356832 bifunctional purine biosynthesis protein from Streptomyces coelicolor (523 aa); NP_388534.1|NC_000964 phosphoribosylaminoimidazole carboxy formyl formyltransferase + inosine-monophosphate cyclohydrolase from Bacillus subtilis (512 aa); P15639|PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase from Escherichia coli (529 aa), FASTA scores: opt: 1147,E(): 0, (44.8% identity in 533 aa overlap); etc. BELONGS TO THE PURH FAMILY.	X2BGN4,P67542,P67542	No	intermediary metabolism and respiration			P67542					X2BGN4,P67542					Rv0957		Rv0957			
NC_002945.3	Mycobrowser_v4	CDS	1062431	1063594	.	+	0	Mb0976	sucC		PROBABLE SUCCINYL-COA SYNTHETASE (BETA CHAIN) SUCC (SCS-BETA)	Mb0976, sucC, len: 387 aa. Equivalent to Rv0951,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Probable sucC,succinyl-Coa synthetase, beta chain (EC 6.2.1.5),equivalent to AL035500|MLCL373_3|NP_301241.1|NC_002677 succinyl-CoA synthase [beta] chain from Mycobacterium leprae (393 aa), FASTA score: (86.7% identity in 391 aa overlap). Also highly similar to others e.g. AB92671.1|AL356832 succinyl-CoA synthetase beta chain from Streptomyces coelicolor (394 aa); P25126|SUCC_THEFL SUCCINYL-COA SYNTHETASE BETA CHAIN from Thermus aquaticus (378 aa); P07460|SUCC_ECOLI succinyl-CoA synthetase beta chain from Escherichia coli (388 aa), FASTA scores: opt: 933, E(): 0, (41.0% identity in 390 aa overlap); etc.	X2BGN9,Q7U0Z1,Q7U0Z1	No	intermediary metabolism and respiration			Q7U0Z1					X2BGN9,Q7U0Z1					Rv0951		Rv0951			
NC_002945.3	Mycobrowser_v4	CDS	1063607	1064518	.	+	0	Mb0977	sucD		PROBABLE SUCCINYL-COA SYNTHETASE (ALPHA CHAIN) SUCD (SCS-ALPHA)	Mb0977, sucD, len: 303 aa. Equivalent to Rv0952,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Probable sucD,succinyl-CoA synthetase, alpha chain (EC 6.2.1.5),equivalent to AL035500|MLCL373_4|NP_301242.1|NC_002677 succinyl-CoA synthase [alpha] chain from Mycobacterium leprae (300 aa), FASTA score: (86.3% identity in 300 aa overlap). Also highly similar to others e.g. CAB92672.1|AL356832 from Streptomyces coelicolor (294 aa); P53591|SUCD_COXBU from Escherichia coli (288 aa), FASTA scores: opt: 855, E(): 0, (53.8% identity in 286 aa overlap); etc. Contains PS00399 ATP-citrate lyase and succinyl-CoA ligases active site, and PS00017 ATP/GTP-binding site motif A (P-loop).	X2BGN0,Q7U0Z0,Q7U0Z0	No	intermediary metabolism and respiration			Q7U0Z0					X2BGN0,Q7U0Z0					Rv0952		Rv0952			
NC_002945.3	Mycobrowser_v4	CDS	1073766	1073987	.	+	0	Mb0984A	vapB9		Possible antitoxin VapB9	Mb0984A, len: 73 aa. Equivalent to Rv0959A len: 73 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB9,antitoxin, part of toxin-antitoxin (TA) operon with Rv0960 (See Arcus et al., 2005; Pandey and Gerdes, 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv1721c	X2BGM8,A0A1R3XXX2	No	virulence, detoxification, adaptation			A0A1R3XXX2					X2BGM8					Rv0959A		Rv0959A			
NC_002945.3	Mycobrowser_v4	CDS	1073984	1074367	.	+	0	Mb0985	vapc9		possible toxin vapc9	Mb0985, -, len: 127 aa. Equivalent to Rv0960, len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 127 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv0065|MTV030.08 (133 aa),FASTA scores: E(): 1.5e-14, (38.3% identity in 128 aa overlap), Rv1720c (129 aa), and Rv0549c (137 aa).	X2BGP9,P64774,P64774	No	virulence, detoxification, adaptation			P64774					X2BGP9,P64774					Rv0960		Rv0960			
NC_002945.3	Mycobrowser_v4	CDS	1078414	1078773	.	+	0	Mb0992	csor		copper-sensitive operon repressor csor	Mb0992, -, len: 119 aa. Equivalent to Rv0967, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 119 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. AE002074|AE002074_11 from Deinococcus radiodurans (102 aa), FASTA scores: opt: 233, E(): 8.6e-10, (47.0% identity in 83 aa overlap); O32222|Z99121|YVGZ from Bacillus subtilis (101 aa), FASTA scores: opt:228, E(): 3.2e-15, (38.0% identity in 92 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0190, and Rv1766.	X2BGF2,Q7U0Y5,Q7U0Y5	No	regulatory proteins			Q7U0Y5					X2BGF2,Q7U0Y5					Rv0967		Rv0967			
NC_002945.3	Mycobrowser_v4	CDS	1079182	1081494	.	+	0	Mb0994	ctpV		PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE CTPV	Mb0994, ctpV, len: 770 aa. Equivalent to Rv0969,len: 770 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 770 aa overlap). Probable ctpV, metal cation transporter P-type ATPase (transmembrane protein) (EC 3.6.3.-), highly similar (except in N-terminus) to others e.g. NP_391230.1|NC_000964 similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); P37279|ATCS_SYNP7|PACS cation-transporting ATPase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (747 aa), FASTA scores: opt: 1851, E(): 0, (52.1% identity in 664 aa overlap); etc. Equivalent to AAK45246.1 from Mycobacterium tuberculosis strain CDC1551 (792 aa) but shorter 22 aa. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES).	Q7U0Y4,A0A1R3XXY2	No	cell wall and cell processes			A0A1R3XXY2				IPR001757,IPR008250,IPR018303,IPR023214,IPR023299,IPR027256	Q7U0Y4					Rv0969		Rv0969			
NC_002945.3	Mycobrowser_v4	CDS	1082214	1083023	.	-	0	Mb0996c	echA7		PROBABLE ENOYL-COA HYDRATASE ECHA7 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb0996c, echA7, len: 269 aa. Equivalent to Rv0971c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 269 aa overlap). Probable echA7,enoyl-CoA hydratase (EC 4.2.1.17), similar to many e.g. CAB95895.1|AL359988 putative enoyl CoA hydratase from Streptomyces coelicolor (247 aa); P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (257 aa),FASTA scores: opt: 369, E(): 2.6e-15, (33.7% identity in 246 aa overlap); etc.	Q7U0Y3,A0A1R3XXB6	No				A0A1R3XXB6				IPR001753,IPR014748	Q7U0Y3										
NC_002945.3	Mycobrowser_v4	CDS	1083023	1084189	.	-	0	Mb0997c	fadE12		acyl-coa dehydrogenase fade12	Mb0997c, fadE12, len: 388 aa. Equivalent to Rv0972c, len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 388 aa overlap). Probable fadE12, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB95893.1|AL359988 putative acyl CoA dehydrogenase from Streptomyces coelicolor (382 aa); P45857|ACDB_BACSU from Bacillus subtilis (379 aa), FASTA scores: opt: 576, E(): 2.3e-26, (29.7% identity in 381 aa overlap); etc.	X2BGF7,Q7U0Y2,Q7U0Y2	No	lipid metabolism			Q7U0Y2					X2BGF7,Q7U0Y2					Rv0972c		Rv0972c			
NC_002945.3	Mycobrowser_v4	CDS	1084186	1086189	.	-	0	Mb0998c	accA2		PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) ACCA2: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)	Mb0998c, accA2, len: 667 aa. Equivalent to Rv0973c,len: 667 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 667 aa overlap). Probable accA2 (alternate gene name: bccA), acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)],highly similar to others e.g. CAB95892.1|AL359988 putative acetyl/propionyl CoA carboxylase alpha subunit from Streptomyces coelicolor (614 aa); NP_250702.1|NC_002516 probable acyl-CoA carboxylase alpha chain from Pseudomonas aeruginosa (655 aa); NP_420971.1|NC_002696 acetyl/propionyl-CoA carboxylase alpha subunit from Caulobacter crescentus ( 654 aa); NP_251581.1|NC_002516 probable biotin carboxylase/biotin carboxyl carrier protein from Pseudomonas aeruginosa (661 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) (654 aa), FASTA scores, opt: 250, E(): 4e-09, (28.6% identity in 182 aa overlap); and Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127 aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in 500 aa overlap). Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site.	Q7U0Y1,A0A1R3XWZ8	No				A0A1R3XWZ8				IPR000089,IPR001882,IPR005479,IPR005481,IPR005482,IPR011053,IPR011054,IPR011761,IPR011764,IPR013815,IPR013816,IPR016185	Q7U0Y1										
NC_002945.3	Mycobrowser_v4	CDS	1086195	1087784	.	-	0	Mb0999c	accD2		PROBABLE ACETYL-/PROPIONYL-COA CARBOXYLASE (BETA SUBUNIT) ACCD2	Mb0999c, accD2, len: 529 aa. Equivalent to Rv0974c,len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 529 aa overlap). Probable accD2,acetyl-/propionyl-CoA carboxylase (beta subunit) (EC 6.4.1.-), highly similar to many e.g. CAB95891.1|AL35998 putative acetyl/propionyl CoA carboxylase beta subunit from Streptomyces coelicolor (532 aa); NP_250704.1|NC_002516 probable acyl-CoA carboxyltransferase beta chain from Pseudomonas aeruginosa (535 aa); BAB16296.1|AB039884 acetyl-CoA carboxylase carboxyltransferase from Myxococcus xanthus (538 aa); NP_420973.1|NC_002696 putative propionyl-CoA carboxylase beta subunit from Caulobacter crescentus (530 aa); etc. Also similar to other from Mycobacterium tuberculosis: Rv2502c|ACCD1, Rv3799c|ACCD4, etc. COULD BELONG TO THE ACCD/PCCB FAMILY.	Q7U0Y0,A0A1R3XWX8	No				A0A1R3XWX8				IPR000022,IPR011762,IPR011763	Q7U0Y0										
NC_002945.3	Mycobrowser_v4	CDS	1087825	1088934	.	-	0	Mb1000c	fadE13		PROBABLE ACYL-COA DEHYDROGENASE FADE13	Mb1000c, fadE13, len: 369 aa. Equivalent to the 5' end of Rv0975c, len: 382 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 349 aa overlap). Probable fadE13, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. T35427 probable acyl-CoA dehydrogenase from Streptomyces coelicolor (382 aa); M74096|HUMACADL_1 Human long chain acyl-CoA dehydrogenase from Homo sapiens (430 aa), FASTA scores: opt: 819, E(): 0, (37.0% identity in 376 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa), FASTA scores: (40.3% identity in 375 aa overlap). Contains PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7U0X9,A0A1R3XX05	No				A0A1R3XX05				IPR006091,IPR009075,IPR009100,IPR013786	Q7U0X9										
NC_002945.3	Mycobrowser_v4	CDS	1216898	1217002	.	+	0	Mb1119	celA2a		PROBABLE CELLULASE CELA2A (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE)	Mb1119, celA2a, len: 34 aa. Equivalent to Rv1089A,len: 34 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 34 aa overlap). Probable celA2a, first part of cellulase (endoglucanase) (EC 3.2.1.4), similar to N-terminus of others.	Q7U0P3,A0A1R3XXC8	No				A0A1R3XXC8					Q7U0P3										
NC_002945.3	Mycobrowser_v4	CDS	1148874	1149554	.	-	0	Mb1055c	kdpE		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN KDPE	Mb1055c, kdpE, len: 226 aa. Equivalent to Rv1027c,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 226 aa overlap). Probable KdpE,transcriptional regulatory protein, similar to others e.g. KDPE_ECOLI|P21866 kdp operon transcriptional regulatory protein from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 691, E(): 0, (47.8% identity in 224 aa overlap); AL021530|SC2E9.13 from Streptomyces coelicolor (227 aa), FASTA scores: opt: 981, E(): 0, (66.4% identity in 226 aa overlap); etc.	Q7U0U2,A0A1R3XX67	No				A0A1R3XX67				IPR001789,IPR001867,IPR011006,IPR011991	Q7U0U2										
NC_002945.3	Mycobrowser_v4	CDS	1097273	1097959	.	+	0	Mb1007	mprA		Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein)	Mb1007, len: 228 aa. Equivalent to Rv0981 len: 228 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 228 aa overlap). MprA,mycobacterial persistence regulator, a two-component response regulator whose expression is required for entrance into and maintenance of persistent infection (see citation below),equivalent to NP_301250.1|NC_002677 putative two-component response regulator from Mycobacterium leprae (228 aa); and highly similar to others from Mycobacterium leprae. Also highly similar to others e.g. AAG36759.1|AF119221_1|AF119221 response regulator from Corynebacterium glutamicum (232 aa); CAB88489.1|AL353816 putative two-component system response regulator from Streptomyces coelicolor (248 aa); BJY09666_1 two-component response regulator (ragA, ragB and rpoH3) from B.japonicum (226 aa), FASTA score: (43.8% identity in 224 aa overlap); BSAJ2571_44 two-component response regulator from Bacillus subtilis (228 aa), FASTA score: (46.4% identity in 224 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv1033c (257 aa); Rv0903c (236 aa), FASTA score: (50.7 identity in 225 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2. Start changed since first submission (-2 aa). MprAB is involved in the regulation of genes in response to environmental stress (See He et al., 2006).	X2BGG7,Q7U0X4,Q7U0X4	No	regulatory proteins			Q7U0X4					X2BGG7,Q7U0X4					Rv0981		Rv0981			
NC_002945.3	Mycobrowser_v4	CDS	1090812	1093583	.	+	0	Mb1002	PE_PGRS16		pe-pgrs family protein pe_pgrs16	Mb1002, PE_PGRS16, len: 923 aa. Equivalent to Rv0977, len: 923 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 923 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to other PGRS-type sequences e.g. AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa), FASTA score: (45.4% identity in 959 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FASTA score: (51.5% identity in 750 aa overlap); etc.	Q7U0X8,A0A1R3XWZ9	No				A0A1R3XWZ9				IPR000084	Q7U0X8										
NC_002945.3	Mycobrowser_v4	CDS	1093800	1094807	.	-	0	Mb1003c	PE_PGRS17		pe-pgrs family protein pe_pgrs17	Mb1003c, PE_PGRS17, len: 335 aa. Similar to Rv0978c, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv, (93.7% identity in 335 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (73.6% identity in 277 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 115 bp to 127 bp substitution leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331 aa).	Q7U0X7,A0A1R3XZ35	No				A0A1R3XZ35				IPR000084,IPR001258,IPR011964,IPR013017,IPR015943	Q7U0X7										
NC_002945.3	Mycobrowser_v4	CDS	1095337	1095510	.	+	0	Mb1005	rpmF		50s ribosomal protein l32 rpmf	Mb1005, rpmF, len: 57 aa. Equivalent to Rv0979A,len: 57 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 57 aa overlap). Probable rpmF, 50S ribosomal protein L32, similar to others e.g. rpmF|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN from Streptomyces coelicolor (56 aa), FASTA scores: E(): 5.1e-09, (63.45% identity in 52 aa overlap); etc. BELONGS TO THE L32P FAMILY OF RIBOSOMAL PROTEINS.	X2BGV8,P0A5V9,P0A5V9	No	information pathways			P0A5V9					X2BGV8,P0A5V9					Rv0979A		Rv0979A			
NC_002945.3	Mycobrowser_v4	CDS	1095529	1096902	.	-	0	Mb1006c	PE_PGRS18		pe-pgrs family protein pe_pgrs18	Mb1006c, PE_PGRS18, len: 457 aa. Equivalent to Rv0980c, len: 457 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 457 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (66.7% identity in 405 aa overlap); Z95844|MTCY493_2 from Mycobacterium tuberculosis (741 aa),FASTA score: (53.0% identity in 394 aa overlap); etc.	Q7U0X5,A0A1R3XXC5	No				A0A1R3XXC5				IPR000084,IPR001258,IPR011045,IPR011964,IPR013017,IPR015943	Q7U0X5										
NC_002945.3	Mycobrowser_v4	CDS	1097959	1099473	.	+	0	Mb1008	mprB		two component sensor kinase mprb	Mb1008, mprB, len: 504 aa. Equivalent to Rv0982,len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 504 aa overlap). Probable mprB, two component sensor kinase, transmembrane protein (EC 2.7.3.-) (see citation below), equivalent to AL035500|MLCL373_16|NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa), FASTA score: (81.0% identity in 521 aa overlap). Also highly similar to others (especially in C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221 sensor kinase from Corynebacterium glutamicum (455 aa); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (481 aa); X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa),FASTA scores: opt: 451, E(): 4.2e-21, (36.0% identity in 303 aa overlap); P30847|BAES_ECOLI SENSOR PROTEIN (EC 2.7.3.-) from Escherichia coli (467 aa), FASTA scores: opt: 412, E(): 1.3e-18, (30.4% identity in 336 aa overlap); etc. Also similar in C-terminal region to C-terminus of Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4 identity in 462 aa overlap).	X2BGP2,Q7U0X3,Q7U0X3	No	regulatory proteins			Q7U0X3					X2BGP2,Q7U0X3					Rv0982		Rv0982			
NC_002945.3	Mycobrowser_v4	CDS	1099517	1100911	.	+	0	Mb1009	pepd		probable serine protease pepd (serine proteinase) (mtb32b)	Mb1009, -, len: 464 aa. Equivalent to Rv0983, len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 464 aa overlap). Probable secreted or membrane serine protease (EC 3.4.21.-), equivalent (but longer 18 aa in N-terminus) to AL035500|MLCL373_17|T45448 probable serine proteinase (EC 3.4.21.-) from Mycobacterium leprae (452 aa), FASTA score: (74.2% identity in 466 aa overlap); and highly similar to others from Mycobacterium leprae. Also highly similar (except in N-terminus) to other proteases e.g. CAC01350.1|AL390975 putative protease from Streptomyces coelicolor (542 aa); NP_440705.1|NC_000911|HtrA serine protease from Synechocystis sp. (452 aa); NP_346646.1|NC_003028 serine protease from Streptococcus pneumoniae (393 aa); etc. Also similar in part to members of the htrA-antigen family e.g. U87242|MTU87242_3|HtrA serine protease from M. tuberculosis (542 aa), FASTA scores: opt: 846, E(): 2e-28,(40.6% identity in 392 aa overlap); and similar to other hypothetical serine proteases e.g. Rv0983, Rv0125, etc.	Q7U0X2,A0A1R3XWZ0	No	intermediary metabolism and respiration			A0A1R3XWZ0				IPR001478,IPR001940,IPR009003	Q7U0X2					Rv0983		Rv0983			
NC_002945.3	Mycobrowser_v4	CDS	1100911	1101456	.	+	0	Mb1010	moaB2		POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB2 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD)	Mb1010, moaB2, len: 181 aa. Equivalent to Rv0984,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 181 aa overlap). Possible moaB2,pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),highly similar to NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa), FASTA score: (92.3% identity in 181 aa overlap). Also similar to others e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); Q56208|MOCB_SYNP7 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN CB from Synechococcus sp. (319 aa), FASTA score: (37.3% identity in 142 aa overlap); C-terminus of NP_197599.1|NC_003076 MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN from Arabidopsis thaliana (670 aa); etc. Also similar to Rv0865|MOG from Mycobacterium tuberculosis (160 aa); and other mog proteins e.g. CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa). COULD BELONG TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Alternative start codon has been suggested in position 1100508.	Q7TTP6,A0A1R3XX15	No				A0A1R3XX15				IPR001453,IPR020817	Q7TTP6										
NC_002945.3	Mycobrowser_v4	CDS	1101476	1101931	.	-	0	Mb1011c	mscL		POSSIBLE LARGE-CONDUCTANCE ION MECHANOSENSITIVE CHANNEL MSCL	Mb1011c, mscL, len: 151 aa. Equivalent to Rv0985c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 151 aa overlap). Possible mscL, large conductance mechanosensitive ion channel (integral membrane protein), equivalent to AL035500|MLCL373_19|NP_301254.1|NC_002677 putative mechanosensitive channel protein from Mycobacterium leprae (154 aa), FASTA score: (71.0% identity in 155 aa overlap). Also highly similar to others e.g. NP_268999.1|NC_002737 putative large conductance mechanosensitive channel from Streptococcus pyogenes (120 aa); CAB90974.1|AL355832 putative mechanosensitive channel from Streptomyces coelicolor (156 aa); Q9X722|MSCL_CLOHI LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL from Clostridium histolyticum (133 aa); Z83337|BSZ83337_6 large conductance mechanosensitive channel from Bacillus subtilis (130 aa),FASTA scores: opt: 248, E(): 8.4e-10, (39.0% identity in 136 aa overlap); U08371|ECU08371_1 large conductance mechanosensitive channel from Escherichia coli strain K-12 (136 aa), FASTA score: (36.6% identity in 134 aa overlap); etc. BELONGS TO THE MSCL FAMILY.	X2BGR4,P0A5K9,P0A5K9	No				P0A5K9					X2BGR4,P0A5K9										
NC_002945.3	Mycobrowser_v4	CDS	1112063	1112674	.	+	0	Mb1022	rimJ		ribosomal-protein-alanine acetyltransferase rimj (acetylating enzyme for n-terminal of ribosomal protein s5)	Mb1022, rimJ, len: 203 aa. Equivalent to Rv0995,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 203 aa overlap). Possible rimJ,ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), equivalent to AL035500|MLCL373_24 probable acyltransferase from Mycobacterium leprae (218 aa), FASTA scores: (86.0% identity in 200 aa overlap). Also similar to others and many acyltransferases e.g. BAB69252.1|AB070946 possible acyltransferase from Streptomyces avermitilis (156 aa); NP_385025.1|NC_003047 PROBABLE RIBOSOMAL-PROTEIN-ALANINE ACETYLTRANSFERASE from Sinorhizobium meliloti (203 aa); P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444 ribosomal-protein-alanine acetyltransferase from Escherichia coli strains K12 and O157:H7 (194 aa), FASTA scores: opt: 247, E(): 1.5e-10, (26.9% identity in 186 aa overlap). SEEMS TO BELONG TO THE ACETYLTRANSFERASE FAMILY,RIMJ SUBFAMILY.	Q7U0W1,A0A1R3XX19	No	information pathways			A0A1R3XX19				IPR000182,IPR016181	Q7U0W1					Rv0995		Rv0995			
NC_002945.3	Mycobrowser_v4	CDS	1117636	1118844	.	+	0	Mb1028	arcA		PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD) (ARGININE DIHYDROLASE)	Mb1028, arcA, len: 402 aa. Equivalent to Rv1001,len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 402 aa overlap). Probable arcA, arginine deiminase (EC 3.5.3.6), similar to e.g. ARCA_PSEAE|P13981 arginine deiminase (417 aa), fasta scores: opt: 581, E(): 1.4e-31, (39.4% identity in 411 aa overlap); also similar to SAGP_STRPY|P16962 streptococcal acid glycoprotein (410 aa), FASTA scores, opt: 823, E():0, (38.3% identity in 402 aa overlap). BELONGS TO THE ARGININE DEIMINASE FAMILY.	X2BGU7,P63552,P63552	No	intermediary metabolism and respiration			P63552					X2BGU7,P63552					Rv1001		Rv1001			
NC_002945.3	Mycobrowser_v4	CDS	1106856	1107833	.	-	0	Mb1016c	grcC2		PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	Mb1016c, grcC2, len: 325 aa. Equivalent to Rv0989c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). Probable grcC2,polyprenyl diphosphate synthetase (EC 2.5.1.-), highly similar to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to heptaprenyl diphosphate synthase component II (menaquinone biosynthesis) from Listeria innocua (321 aa); NP_371994.1|NC_002758 heptaprenyl diphosphate syntase component II from Staphylococcus aureus subsp. aureus Mu50 (319 aa); P55785|HEP2_BACST heptaprenyl diphosphate synthase component from Bacillus subtilis (323 aa), FASTA scores: opt: 496, E(): 1.4e-24, (31.4% identity in 306 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins e.g. Rv0562|grcC1|NP_215076.1|MTCY25D10.41 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (335 aa); Rv3383, Rv3398c,Rv2173, etc. SEEMS TO BELONG TO THE FPP/GGPP SYNTHETASES FAMILY.	Q7U0W7,A0A1R3XXD6	No				A0A1R3XXD6				IPR000092,IPR008949,IPR017446	Q7U0W7										
NC_002945.3	Mycobrowser_v4	CDS	1109723	1110643	.	+	0	Mb1020	galU		utp--glucose-1-phosphate uridylyltransferase galu (udp-glucose pyrophosphorylase) (udpgp) (alpha-d-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase)	Mb1020, galU, len: 306 aa. Equivalent to Rv0993,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 306 aa overlap). Probable galU,UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9),equivalent to AL035500|MLCL373_22 putative UTP-glucose-1-phosphate uridylyltransferase from Mycobacterium leprae (306 aa), FASTA score: (89.7% identity in 302 aa overlap). Also highly similar to others e.g. AB59678.1|AL132674 UTP-glucose-1-phosphate uridylyltransferase from Streptomyces coelicolor (303 aa); NP_244519.1|NC_002570 UTP-glucose-1-phosphate uridylyltransferase from Bacillus halodurans (297 aa); P25520|GALU_ECOLI|B1236|Z2012|ECS17 UTP--glucose-1-phosphate uridylyltransferase from Escherichia coli strains K12 and O157:H7 (301 aa), FASTA scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa overlap); etc. BELONGS TO THE PROKARYOTIC UDPGP FAMILY.	Q7U0W3,A0A1R3XX25	No	intermediary metabolism and respiration			A0A1R3XX25				IPR005835	Q7U0W3					Rv0993		Rv0993			
NC_002945.3	Mycobrowser_v4	CDS	1110720	1112000	.	+	0	Mb1021	moeA1		PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA1	Mb1021, moeA1, len: 426 aa. Equivalent to Rv0994,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 426 aa overlap). Probable moeA1,molybdenum cofactor biosynthesis protein, equivalent to AL035500|MLCL373_23 putative molybdopterin biosynthesis protein from Mycobacterium leprae (424 aa), FASTA score: (88.3% identity in 426 aa overlap). Also highly similar to many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis protein from Streptomyces coelicolor (424 aa); NP_385769.1|NC_003047 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Sinorhizobium meliloti (406 aa); P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein from Escherichia coli (411 aa), FASTA scores: opt: 519,E(): 1.3e-24, (32.3% identity in 402 aa overlap); etc. Also similar to MOEA2|Rv0438c|MTV037.02c PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (405 aa). Note that previously known as moeA.	Q7U0W2,A0A1R3XX20	No				A0A1R3XX20				IPR001453,IPR005110,IPR005111,IPR020817	Q7U0W2										
NC_002945.3	Mycobrowser_v4	CDS	1133785	1134360	.	-	0	Mb1042c	pth		PROBABLE PEPTIDYL-TRNA HYDROLASE PTH	Mb1042c, pth, len: 191 aa. Equivalent to Rv1014c,len: 191 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 191 aa overlap). Probable pth,peptidyl-tRNA hydrolase (EC 3.1.1.29), similar to PTH_ECOLI|P23932 peptidy l-trna hydrolase from Escherichia coli (194 aa), FASTA scores: opt: 472, E(): 2.3e-25,(39.6% identity in 187 aa overlap). BELONGS TO THE PTH FAMILY.	X2BGI9,P65866,P65866	No				P65866					X2BGI9,P65866										
NC_002945.3	Mycobrowser_v4	CDS	1122673	1124109	.	-	0	Mb1032c	pabB		Probable para-aminobenzoate synthase component I PABD	Mb1032c, pabB, len: 478 aa. Similar to Rv1005c,len: 458 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 457 aa overlap). Probable PabD,para-aminobenzoate synthase component I (EC 4.1.3.-). Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase component I from Escherichia coli (453 aa), FASTA scores: opt: 589, E(): 1.8e-27, (40.7% identity in 268 aa overlap). Similar to Mycobacterium tuberculosis Rv1609,Rv3215, Rv2386c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (g-a) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (478 aa versus 458 aa).	Q7VF03,A0A1R3XZ71	No				A0A1R3XZ71				IPR005801,IPR005802,IPR015890,IPR019999	Q7VF03										
NC_002945.3	Mycobrowser_v4	CDS	1125895	1127454	.	-	0	Mb1034c	metS		methionyl-trna synthetase mets (metrs) (methionine--trna ligase)	Mb1034c, metS, len: 519 aa. Equivalent to Rv1007c,len: 519 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 519 aa overlap). Probable metS (MetG),methionyl-tRNA synthetase (EC 6.1.1.10), similar to many e.g. SYM_BACSU|P37465 methionyl-tRNA synthetase from Bacillus subtilus (664 aa), FASTA scores: opt: 1506, E(): 0, (44.9% identity in 492 aa overlap); similar to other M. tuberculosis tRNA synthases e.g. Rv2448c, Rv1536, Rv0041. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. STRONG, TO CYSTEINYL-TRNA SYNTHETASE.	X2BGZ0,P59952,P59952	No				P59952					X2BGZ0,P59952										
NC_002945.3	Mycobrowser_v4	CDS	1127540	1128334	.	+	0	Mb1035	tatD		Probable deoxyribonuclease TatD (YjjV protein)	Mb1035, tatD, len: 264 aa. Equivalent to Rv1008,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable tatD (alternate gene name: yjjV), deoxyribonuclease (EC 3.1.21.-), component of twin arginine translocation protein export system (see citation below for more information). Similar to many members of the YBL055C/YJJV family e.g. YCFH_ECOLI|P37346 Putative deoxyribonuclease ycfH (EC 3.1.21.-) (265 aa), fasta scores: opt: 487, E(): 1.4e-24, (36.7% identity in 270 aa overlap). Also similar to P37545|YABD_BACSU Putative deoxyribonuclease yabD (255 aa), FASTA scores: opt: 599, E(): 7.7e-33, (40.1% identity in 262 aa overlap). Contains PS01137 Hypothetical YBL055c/yjjV family signature 1, and PS01091 Hypothetical YBL055c/yjjV family signature 3.	Q7VF02,A0A1R3XXF5	No	cell wall and cell processes			A0A1R3XXF5				IPR001130,IPR015991,IPR018228	Q7VF02					Rv1008		Rv1008			
NC_002945.3	Mycobrowser_v4	CDS	1128542	1129630	.	+	0	Mb1036	rpfB		Probable resuscitation-promoting factor rpfB	Mb1036, rpfB, len: 362 aa. Equivalent to Rv1009,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 362 aa overlap). Probable rpfB,resuscitation-promoting factor (see citation below),similar to others from Mycobacterium tuberculosis: Rv2450c|MTV008.06c|RPFE PROBABLE RESUSCITATION-PROMOTING FACTOR (172 aa), FASTA scores: E(): 1.9e-19, (42.9% identity in 147 aa overlap); Rv0867c|RPFA, Rv1884c|RPFC,and Rv2389c|RPFD. Possible lipoprotein; contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7VF01,A0A1R3XX37	No	cell wall and cell processes			A0A1R3XX37				IPR007137,IPR010618,IPR011098,IPR023346	Q7VF01					Rv1009		Rv1009			
NC_002945.3	Mycobrowser_v4	CDS	1129603	1130556	.	+	0	Mb1037	ksgA		PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase)	Mb1037, ksgA, len: 317 aa. Equivalent to Rv1010,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 317 aa overlap). Probable ksgA,dimethyladenosine transferase (EC 2.1.1.-), similar to many e.g. KSGA_BACSU|P37468 dimethyladenosine transferase from Bacillus subtilus (292 aa), FASTA scores: opt: 524,E(): 1.5e-28, (37.2% identity in 274 aa overlap); similar to Mycobacterium tuberculosis hypothetical protein Rv1988. Contains PS01131 Ribosomal RNA adenine dimethylases signature.	X2BGQ3,P66661,P66661	No	information pathways			P66661					X2BGQ3,P66661					Rv1010		Rv1010			
NC_002945.3	Mycobrowser_v4	CDS	1130642	1131562	.	+	0	Mb1038	ispE		Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ISPE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)	Mb1038, ispE, len: 306 aa. Equivalent to Rv1011,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 306 aa overlap). Probable ispE,4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.-), similar to others e.g. Q9K3R6|ISPE_STRCO Streptomyces coelicolor (299 aa), FASTA scores: opt: 925,E(): 2.7e-49, (54.5% identity in 297 overlap); etc. BELONGS TO THE ISPE FAMILY.	X2BGV6,P65179,P65179	No	intermediary metabolism and respiration			P65179					X2BGV6,P65179					Rv1011		Rv1011			
NC_002945.3	Mycobrowser_v4	CDS	1132077	1133711	.	+	0	Mb1041	pks16		PUTATIVE POLYKETIDE SYNTHASE PKS16	Mb1041, pks16, len: 544 aa. Equivalent to Rv1013,len: 544 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 544 aa overlap). Putative pks16,polyketide synthase, similar to many e.g. N-terminus of Q50857|U24657 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa), FASTA scores: opt: 526, E(): 1.4e-25, (29.3% identity in 542 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7U0V1,A0A1R3XX39	No				A0A1R3XX39				IPR000873,IPR020845,IPR028154	Q7U0V1										
NC_002945.3	Mycobrowser_v4	CDS	1134373	1135020	.	-	0	Mb1043c	rplY		50s ribosomal protein l25 rply	Mb1043c, rplY, len: 215 aa. Equivalent to Rv1015c,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 215 aa overlap). Probable rplY, 50s ribosomal protein L25, similar to RL25_ECOLI|P02426 50s ribosomal protein L25 from Escherichia coli (94 aa), FASTA scores: opt: 182, E(): 2.5e-05, (38.4% identity in 86 aa overlap) and to CTC_BACSU|P14194 general stress protein from Bacillus subtilis (203 aa), FASTA scores: opt: 260,E(): 1.4e-09, (28.4% identity in 201 aa overlap). BELONGS TO THE L25P FAMILY OF RIBOSOMAL PROTEINS.	X2BGQ7,P66122,P66122	No				P66122					X2BGQ7,P66122										
NC_002945.3	Mycobrowser_v4	CDS	1135154	1135912	.	-	0	Mb1044c	lpqT		probable conserved lipoprotein lpqt	Mb1044c, lpqT, len: 252 aa. Equivalent to 5' end of Rv1016c, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv, (98.9% identity in 190 aa overlap). Probable lpqT, conserved lipoprotein. Similar to several M. tuberculosis hypothetical proteins e.g. Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310 aa), FASTA scores: opt: 329, E(): 2e-17, (32.3% identity in 229 aa overlap); Rv0583c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cacgc-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	X2BGW0,Q7U0V0,Q7U0V0	No				Q7U0V0					X2BGW0,Q7U0V0										
NC_002945.3	Mycobrowser_v4	CDS	1135948	1136928	.	-	0	Mb1045c	prsA		PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE PRSA (Phosphoribosyl pyrophosphate synthetase) (PRPP synthetase)	Mb1045c, prsA, len: 326 aa. Equivalent to Rv1017c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable prsA,ribose-phosphate pyrophosphokinase (EC 2.7.6.1), highly similar to others e.g. KPRS_ECOLI|P08330 ribose-phosphate pyrophosphokinase from Escherichia coli (314 aa), FASTA scores: opt: 826, E(): 0, (43.8% identity in 317 aa overlap). Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature; contains PS00144 Asparaginase / glutaminase active site signature 1. BELONGS TO THE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE FAMILY. COFACTOR: BOTH INORGANIC PHOSPHATE AND MAGNESIUM ION ARE REQUIRED FOR ENZYME STABILITY AND ACTIVITY (by similarity).	X2BH02,P65233,P65233	No				P65233					X2BH02,P65233										
NC_002945.3	Mycobrowser_v4	CDS	1137020	1138507	.	-	0	Mb1046c	glmU		Probable UDP-N-acetylglucosamine pyrophosphorylase glmU	Mb1046c, glmU, len: 495 aa. Equivalent to Rv1018c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 495 aa overlap). Probable glmU,UDP-n-acetylglucosamine pyrophosphorylase (EC 2.7.7.23),similar to GCAD_BACSU|P14192 UDP-n-acetylglucosamine pyrophosphorylase (456 aa), FASTA scores: opt: 1150, E(): 0, (40.0% identity in 453 aa overlap). Similar to various Mycobacterium tuberculosis sugar-phosphate transferases e.g. Rv0334, Rv1213, Rv3264c, etc.	X2BGT8,Q7VF00,Q7VF00	No				Q7VF00					X2BGT8,Q7VF00										
NC_002945.3	Mycobrowser_v4	tRNA	1138523	1138594	.	-	0	glnT	glnT		tRNA-Gln	glnT, len: 72 nt. Equivalent to glnT, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Gln, anticodon ttg.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1139414	1143118	.	+	0	Mb1048	mfd		PROBABLE TRANSCRIPTION-REPAIR COUPLING FACTOR MFD (TRCF)	Mb1048, mfd, len: 1234 aa. Equivalent to Rv1020,len: 1234 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1234 aa overlap). Probable mfd,transcription-repair coupling factor, similar to many e.g. MFD_ECOLI|P30958 transcription-repair coupling factor from Escherichia coli (1148 aa), FASTA scores: opt: 1900, E(): 0, (37.9% identity in 1107 aa overlap). Also similar to M. tuberculosis Rv2973c and Rv1633. Contains PS00017 ATP/GTP-binding site motif A (P-loop). IN THE N-TERMINAL SECTION; BELONGS TO THE UVRB FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HELICASE FAMILY. RECG SUBFAMILY.	X2BGR0,P64327,P64327	No	information pathways			P64327					X2BGR0,P64327					Rv1020		Rv1020			
NC_002945.3	Mycobrowser_v4	CDS	1144183	1144914	.	+	0	Mb1050	lpqU		probable conserved lipoprotein lpqu	Mb1050, lpqU, len: 243 aa. Equivalent to Rv1022,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 243 aa overlap). Probable lpqU conserved lipoprotein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1230c|MTV006.02C,FASTA scores: E(): 2.8e-18, (37.9% identity in 240 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa), FASTA scores: opt: 474, E(): 2.7e-21, (42.2% identity in 211 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U0U7,A0A1R3XX58	No	cell wall and cell processes			A0A1R3XX58				IPR023346	Q7U0U7					Rv1022		Rv1022			
NC_002945.3	Mycobrowser_v4	CDS	1145011	1146300	.	+	0	Mb1051	eno		PROBABLE ENOLASE ENO	Mb1051, eno, len: 429 aa. Equivalent to Rv1023,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 429 aa overlap). Probable eno, enolase (EC 4.2.1.11), highly similar to others e.g. ENO_ECOLI|P08324 enolase from Escherichia coli (431 aa),FASTA scores: opt: 1487, E(): 0, (55.5% identity in 422 aa overlap); etc. MAGNESIUM IS REQUIRED FOR CATALYSIS AND FOR STABILIZING THE DIMER. BELONGS TO THE ENOLASE FAMILY.	X2BGU2,Q7U0U6,Q7U0U6	No	intermediary metabolism and respiration			Q7U0U6					X2BGU2,Q7U0U6					Rv1023		Rv1023			
NC_002945.3	Mycobrowser_v4	CDS	1149551	1152133	.	-	0	Mb1056c	kdpD		PROBABLE SENSOR PROTEIN KDPD	Mb1056c, kdpD, len: 860 aa. Equivalent to Rv1028c,len: 860 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 860 aa overlap). Probable kdpD, sensor protein (EC 2.7.3.-), similar to others e.g. KDPD_ECOLI|P21865 sensor protein from Escherichia coli strain K12 (894 aa), FASTA scores: opt: 1041, E(): 0,(32.3% identity in 888 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7U0U1,A0A1R3XXH9	No				A0A1R3XXH9				IPR003594,IPR003661,IPR003852,IPR004358,IPR005467,IPR006016,IPR009082,IPR014729,IPR027417	Q7U0U1										
NC_002945.3	Mycobrowser_v4	CDS	1152367	1152459	.	+	0	Mb1057	kdpF		Probable membrane protein kdpF	Mb1057, kdpF, len: 30 aa. Equivalent to Rv1028A,len: 30 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 30 aa overlap). Probable kdpF, membrane protein, showing similarity with P36937|KDPF_ECOLI|B0698.1 PROTEIN KDPF from Escherichia coli strain K12 (see citation below) (27% identity); and KdpF protein from Streptomyces coelicolor (51% identity).	Q7VEZ9,A0A1R3XX55	No	cell wall and cell processes			A0A1R3XX55				IPR011726	Q7VEZ9					Rv1028A		Rv1028A			
NC_002945.3	Mycobrowser_v4	CDS	1152459	1154174	.	+	0	Mb1058	kdpA		Probable Potassium-transporting ATPase A chain KDPA (Potassium-translocating ATPase A chain) (ATP phosphohydrolase [potassium-transporting] A chain) (Potassium binding and translocating subunit A)	Mb1058, kdpA, len: 571 aa. Equivalent to Rv1029,len: 571 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 571 aa overlap). Probable kdpA,potassium-transporting ATPase A chain (transmembrane protein) (EC 3.6.3.12), similar to others e.g. ATKA_ECOLI|P03959|KDPA|B0698 potassium-transporting ATPase A chain from Escherichia coli strain K12 (557 aa), FASTA scores: opt: 1763, E(): 0, (50.4% identity in 569 aa overlap); etc. BELONGS TO THE KDPA FAMILY.	X2BGR6,P65210,P65210	No	cell wall and cell processes			P65210					X2BGR6,P65210					Rv1029		Rv1029			
NC_002945.3	Mycobrowser_v4	CDS	1154171	1156300	.	+	0	Mb1059	kdpB		Probable Potassium-transporting P-type ATPase B chain KDPB (Potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium binding and translocating subunit B)	Mb1059, kdpB, len: 709 aa. Equivalent to Rv1030,len: 709 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 709 aa overlap). Probable kdpB,potassium-transporting P-type ATPase B chain (transmembrane protein) (EC 3.6.3.12), similar to others e.g. ATKB_ECOLI|P03960 potassium-transporting ATPase B chain from Escherichia coli strain K12 (682 aa), FASTA scores: opt: 1481, E(): 0, (63.4% identity in 686 aa overlap); etc. Very similar to AL078610|SCH35.47 H+/K+-exchanging ATPase (EC 3.6.1.36) chain B from Streptomyces coelicolor (707 aa), FASTA scores: opt: 2731,E(): 0, (71.6% identity in 676 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site.	X2BGX3,P63682,P63682	No	cell wall and cell processes			P63682					X2BGX3,P63682					Rv1030		Rv1030			
NC_002945.3	Mycobrowser_v4	CDS	1156300	1156869	.	+	0	Mb1060	kdpC		Probable Potassium-transporting ATPase C chain KDPC (Potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (Potassium binding and translocating subunit C)	Mb1060, kdpC, len: 189 aa. Equivalent to Rv1031,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 189 aa overlap). Probable kdpC,potassium-transporting ATPase C chain (membrane protein) (EC 3.6.3.12), similar to others e.g. ATKC_ECOLI|P03961 potassium-transporting ATPase C chain from Escherichia coli strain K12 (190 aa), FASTA scores: opt: 475, E(): 3.1e-24, (45.7% identity in 186 aa overlap); etc. BELONGS TO THE KDPC FAMILY.	X2BH18,P65212,P65212	No	cell wall and cell processes			P65212					X2BH18,P65212					Rv1031		Rv1031			
NC_002945.3	Mycobrowser_v4	CDS	1156873	1158402	.	-	0	Mb1061c	trcS		TWO COMPONENT SENSOR HISTIDINE KINASE TRCS	Mb1061c, trcS, len: 509 aa. Equivalent to Rv1032c,len: 509 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 509 aa overlap). trcS, two component sensor histidine kinase protein (EC 2.7.3.-) (see citations below), similar to YV16_MYCLE|P54883 probable sensor-like histidine kinase from Mycobacterium leprae (443 aa), FASTA scores: opt: 392, E(): 3.8e-18, (31.7% identity in 334 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.	Q7U0U0,A0A1R3XX59	No				A0A1R3XX59				IPR003594,IPR003660,IPR003661,IPR004358,IPR005467,IPR009082	Q7U0U0										
NC_002945.3	Mycobrowser_v4	CDS	1158410	1159183	.	-	0	Mb1062c	trcR		TWO COMPONENT TRANSCRIPTIONAL REGULATOR TRCR	Mb1062c, trcR, len: 257 aa. Equivalent to Rv1033c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). trcR, two-component regulatory protein (see citations below), similar to Q50825 TWO COMPONENT RESPONSE REGULATOR from Mycobacterium tuberculosis (234 aa), FASTA scores: opt: 628, E(): 0,(46.0% identity in 226 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.	Q7U0T9,A0A1R3XX60	No				A0A1R3XX60				IPR001789,IPR001867,IPR011006,IPR011991,IPR016032	Q7U0T9										
NC_002945.3	Mycobrowser_v4	CDS	1160991	1161275	.	-	0	Mb1066c	esxI		putative esat-6 like protein esxi (esat-6 like protein 1)	Mb1066c, esxI, len: 94 aa. Equivalent to Rv1037c,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 94 aa overlap). esxI, conserved hypothetical protein, member of ESAT-6 family, highly similar to many Mycobacterial hypothetical proteins e.g. Q49946|ES6X_MYCLE|U1756D PUTATIVE ESAT-6 LIKE PROTEIN X from Mycobacterium leprae (95 aa), FASTA scores: opt: 409,E(): 6.3e-23, (64.15% identity in 92 aa overlap); Rv3619c,Rv1198, Rv2346c, etc from Mycobacterium tuberculosis. Strictly identical to P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT3721 PUTATIVE ESAT-6 LIKE PROTEIN 1 (94 aa). BELONGS TO THE ESAT6 FAMILY.	X2BGV7,P59802	No				P59802					X2BGV7										
NC_002945.3	Mycobrowser_v4	CDS	1161302	1161598	.	-	0	Mb1067c	esxJ		esat-6 like protein esxj (esat-6 like protein 2)	Mb1067c, esxJ, len: 98 aa. Equivalent to Rv1038c,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 98 aa overlap). esxJ, putative ESAT-6 like protein 2, similar to Q49945|U1756C, Mycobacterium leprae (100 aa), FASTA scores: opt: 375, E(): 7.7e-21,(58.3% identity in 96 aa overlap), almost identical to Rv1197, Rv1792, Rv2347c and Rv3620c. BELONGS TO THE ESAT6 FAMILY.	X2BGJ8,P0DOB0	No				P0DOB0					X2BGJ8										
NC_002945.3	Mycobrowser_v4	CDS	1161744	1162919	.	-	0	Mb1068c	PPE15		ppe family protein ppe15	Mb1068c, PPE15, len: 391 aa. Equivalent to Rv1039c,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 391 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv2768c|AL008967|MTV002_33 Mycobacterium tuberculosis H37Rv (394 aa), FASTA scores: opt: 1721, E(): 0, (70.4% identity in 398 aa overlap).	Q7U0T5,A0A1R3XX65	No				A0A1R3XX65				IPR000030,IPR022171	Q7U0T5										
NC_002945.3	Mycobrowser_v4	CDS	1162996	1163823	.	-	0	Mb1069c	PE8		pe family protein pe8	Mb1069c, PE8, len: 275 aa. Equivalent to Rv1040c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Member of the Mycobacterium tuberculosis PE family, most similar to AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 aa), FASTA scores: opt: 1111, E(): 0, (68.6% identity in 283 aa overlap).	Q7U0T4,A0A1R3XX54	No				A0A1R3XX54				IPR000084,IPR022171	Q7U0T4										
NC_002945.3	Mycobrowser_v4	CDS	1181132	1182763	.	+	0	Mb1087	fadD14		PROBABLE MEDIUM CHAIN FATTY-ACID-COA LIGASE FADD14 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb1087, fadD14, len: 543 aa. Equivalent to Rv1058,len: 543 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 543 aa overlap). Probable fadD14,medium-chain fatty-acid-CoA synthetase (EC 6.2.1.-),highly similar to many e.g. CAC32346.1|AL583945 putative fatty acid CoA ligase from Streptomyces coelicolor (558 aa); N-terminus of NP_419738.1|NC_002696 medium-chain-fatty-acid--CoA ligase from Caulobacter crescentus (1006 aa); Q00594|ALKK_PSEOL MEDIUM-CHAIN-FATTY-ACID--COA LIGASE (EC 6.2.1.-) from Pseudomonas oleovorans (546 aa), FASTA scores: opt: 1468,E(): 0, (41.1% identity in 538 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7U0R8,A0A1R3XX85	No				A0A1R3XX85				IPR000873,IPR020845,IPR025110	Q7U0R8										
NC_002945.3	Mycobrowser_v4	CDS	1187352	1187771	.	-	0	Mb1093c	lpqV		possible lipoprotein lpqv	Mb1093c, lpqV, len: 139 aa. Equivalent to Rv1064c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 139 aa overlap). Putative lipoprotein LpqV. Has N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	X2BGU0,P65311,P65311	No				P65311					X2BGU0,P65311										
NC_002945.3	Mycobrowser_v4	CDS	1188869	1190884	.	-	0	Mb1096c	PE_PGRS19		pe-pgrs family protein pe_pgrs19	Mb1096c, PE_PGRS19, len: 671 aa. Equivalent to Rv1067c, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (98.5% identity in 673 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv3388|MTV004.46 from Mycobacterium tuberculosis (731 aa),FASTA scores: opt: 2227, E(): 0, (55.6% identity in 710 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1, probably fortuitous. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, 2 deletions each of 3 bp (ccg-* and cgc-*) and a 18 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa).	Q7U0R1,A0A1R3XXL9	No				A0A1R3XXL9				IPR000084	Q7U0R1										
NC_002945.3	Mycobrowser_v4	CDS	1191217	1193508	.	-	0	Mb1097c	PE_PGRS20		pe-pgrs family protein pe_pgrs20	Mb1097c, PE_PGRS20, len: 763 aa. Similar to Rv1068c, len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, (59.8% identity in 766 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AL021897|MTV017_19 M. tuberculosis H37Rv (667 aa), FASTA scores: opt: 1875, E(): 0, (55.0% identity in 667 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa).	Q7U0R0,A0A1R3XX95	No				A0A1R3XX95				IPR000084	Q7U0R0										
NC_002945.3	Mycobrowser_v4	CDS	1216980	1217435	.	+	0	Mb1120	celA2b		PROBABLE CELLULASE CELA2B (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE)	Mb1120, celA2b, len: 151 aa. Equivalent to Rv1090,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 151 aa overlap). Probable celA2b, second part of cellulase (endoglucanase) (EC 3.2.1.4), similar to C-terminus of others e.g. O08468 cellulase CEL2 from Streptomyces halstedi (377 aa), FASTA scores: opt: 554,E(): 1.2e-30, (52.0% identity in 152 aa overlap); etc. Gene appears to have been inactivated by frameshift mutations but no errors could be found that would account for this.	Q7U0P2,A0A1R3XXB8	No				A0A1R3XXB8				IPR002594,IPR008985,IPR013319	Q7U0P2										
NC_002945.3	Mycobrowser_v4	CDS	1202127	1203020	.	+	0	Mb1105	lipU		possible lipase lipu	Mb1105, lipU, len: 297 aa. Equivalent to Rv1076,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 297 aa overlap). Putative lipU, lipase (EC 3.1.-.-), very similar to several Mycobacterium tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c (277 aa), FASTA scores: opt: 1225, E(): 0, (76.0% identity in 246 aa overlap); Rv1426c, etc. Also similar to esterases and lipases of around 300 aa e.g. Q44087 ESTERASE PRECURSOR from Acinetobacter lwoffii esterase (303), FASTA scores: opt: 427, E(): 1.9e-21, (32.5% identity in 280 aa overlap). Equivalent to AL035159|MLCB1450 _7 Mycobacterium leprae (335 aa), FASTA scores: opt: 1588, E(): 0, (79.7% identity in 296 aa overlap).	Q7U0Q3,A0A1R3XXB5	No	intermediary metabolism and respiration			A0A1R3XXB5				IPR002168,IPR013094	Q7U0Q3					Rv1076		Rv1076			
NC_002945.3	Mycobrowser_v4	CDS	1199516	1200733	.	-	0	Mb1103c	fadA3		PROBABLE BETA-KETOACYL CoA THIOLASE FADA3	Mb1103c, fadA3, len: 405 aa. Equivalent to Rv1074c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 405 aa overlap). Probable fadA3,beta-ketoacyl CoA thiolase (EC 2.3.1.-), highly similar to many involved in beta-oxidation e.g. CAB89028.1|AL353870 beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor (395 aa); P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA thiolase from Escherichia coli (401 aa), FASTA scores: opt: 1034, E(): 5.4e-56, (43.5% identity in 416 aa overlap) and X97452 acetyl-CoA acetyltransferase (thiolase) from Escherichia coli (401 aa), FASTA scores: opt: 1043, E(): 0, (43.4% identity in 415 aa overlap); Q43935|CATF_ACICA beta-ketoadipyl CoA thiolase from Acinetobacter calcoaceticus (401 aa), FASTA scores: opt: 992, E(): 0, (41.5% identity in 415 aa overlap); etc. Contains PS00737 Thiolases signature 2, and PS00445 FGGY family of carbohydrate kinases signature 2, although this is probably fortuitous. BELONGS TO THE THIOLASE FAMILY.	Q7U0Q5,A0A1R3XZD9	No				A0A1R3XZD9				IPR002155,IPR016038,IPR016039,IPR020613,IPR020616,IPR020617	Q7U0Q5										
NC_002945.3	Mycobrowser_v4	CDS	1195630	1196403	.	-	0	Mb1099c	echA8		PROBABLE ENOYL-CoA HYDRATASE ECHA8 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)	Mb1099c, echA8, len: 257 aa. Equivalent to Rv1070c,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). Probable echA8,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to O07137|B1306.05c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (257 aa), FASTA scores: opt: 1417, E(): 0, (86.4% identity in 257 aa overlap). Also highly similar to others e.g. NP_106219.1|NC_002678 enoyl CoA hydratase from Mesorhizobium loti (257 aa); L39265|RHMRPST_2 enoyl-CoA hydratase from Rhizobium melilotii (257 aa), FASTA scores: opt: 1100, E(): 0,(66.9% identity in 257 aa overlap); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa); etc. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-CoA HYDRATASE/ISOMERASE FAMILY. TBparse score is 0.881.	X2BGZ4,P64017,P64017	No				P64017					X2BGZ4,P64017										
NC_002945.3	Mycobrowser_v4	CDS	1196415	1197452	.	-	0	Mb1100c	echA9		POSSIBLE ENOYL-COA HYDRATASE ECHA9 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb1100c, echA9, len: 345 aa. Equivalent to Rv1071c,len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 345 aa overlap). Possible echA9,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7% identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa); NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (350 aa); Q19278 PROTEIN SIMILAR TO ENOYL-COA HYDRATASES from Caenorhabditis elegans (386), FASTA scores: opt: 787, E(): 0, (38.5% identity in 348 aa overlap); etc.	Q7U0Q8,A0A1R3XXA9	No				A0A1R3XXA9				IPR001753,IPR014748	Q7U0Q8										
NC_002945.3	Mycobrowser_v4	CDS	1203077	1204471	.	+	0	Mb1106	cbs		Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450)	Mb1106, cbs, len: 464 aa. Equivalent to Rv1077,len: 464 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 464 aa overlap). Probable cbs (previously cysM2), cystathionine beta-synthase (EC 4.2.1.22), similar throughout its length to many eukaryotic cystathionine beta-synthases e.g. P32232|CBS_RAT CYSTATHIONINE BETA-SYNTHASE (560 aa), FASTA scores: opt: 951, E(): 0, (40.2% identity in 450 aa overlap); also similar in N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 855, E(): 0, (46.8% identity in 314 overlap); and other cysteine synthase proteins e.g. Rv1336, Rv0848, etc. Contains PS00217 Sugar transport proteins signature 2 probably spurious. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY.	Q7VEZ8,A0A1R3XXM8	No	intermediary metabolism and respiration			A0A1R3XXM8				IPR000644,IPR001926,IPR005857	Q7VEZ8					Rv1077		Rv1077			
NC_002945.3	Mycobrowser_v4	CDS	1204673	1205395	.	+	0	Mb1107	pra		Probable Proline-rich antigen homolog pra	Mb1107, pra, len: 240 aa. Equivalent to Rv1078,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 240 aa overlap). Probable pra,Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1 proline rich antigen from Mycobacterium leprae (249 aa), FASTA scores: opt: 1162, E(): 3.3e-30,(64.8% identity in 253 aa overlap). Has potential hydrophobic domains.	Q7U0Q2,A0A1R3XXA6	No	conserved hypotheticals			A0A1R3XXA6				IPR010432	Q7U0Q2					Rv1078		Rv1078			
NC_002945.3	Mycobrowser_v4	CDS	1215894	1216328	.	+	0	Mb1117	PE9		pe family protein pe9	Mb1117, PE9, len: 144 aa. Equivalent to Rv1088,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 144 aa overlap). Member of Mycobacterium tuberculosis PE family, similar to many others e.g. Z96071|MTCI418B_6 Mycobacterium tuberculosis cosmid (487 aa), FASTA scores: opt: 318, E(): 7.3e-14, (60.9% identity in 87 aa overlap) - except it appears to be frameshifted around codon 84. No error to account for frameshift could be found.	Q7U0P5,A0A1R3XXB3	No	PE/PPE			A0A1R3XXB3				IPR000084	Q7U0P5					Rv1088		Rv1088			
NC_002945.3	Mycobrowser_v4	CDS	1205427	1206593	.	+	0	Mb1108	metB		cystathionine gamma-synthase metb (cgs) (o-succinylhomoserine [thiol]-lyase)	Mb1108, metB, len: 388 aa. Equivalent to Rv1079,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 388 aa overlap). Probable metB,cystathionine gamma-synthase (EC 4.2.99.9) (see citation below). P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE from Mycobacterium leprae (EC 4.2.1.22) (388 aa), FASTA scores: opt: 2220, E(): 0, (87.3% identity in 387 aa overlap). Also similar to other Mycobacterium tuberculosis enzymes involved in methionine synthesis e.g. Rv0391 and Rv3340. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY.	X2BGV2,P66876,P66876	No	intermediary metabolism and respiration			P66876					X2BGV2,P66876					Rv1079		Rv1079			
NC_002945.3	Mycobrowser_v4	CDS	1206664	1207158	.	-	0	Mb1109c	greA		PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA (Transcript cleavage factor greA)	Mb1109c, greA, len: 164 aa. Equivalent to Rv1080c,len: 164 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 164 aa overlap). Probable greA,transcription elongation factor G, closest to P46808|GREA_MYCLE TRANSCRIPTION ELONGATION FACTOR G from Mycobacterium leprae (202 aa), FASTA scores: opt: 1005,E(): 0, (94.5% identity in 164 aa overlap); and similar to many e.g. P21346|GREA_ECOLI from Escherichia coli (158 aa), FASTA scores: opt: 257, E(): 5.7e-10, (37.2% identity in 148 aa overlap); etc. Contains two PS00829 and one PS00830 Prokaryotic transcription elongation factors signatures 1 and 2, respectively. BELONGS TO THE GREA/GREB FAMILY.	X2BH00,P64280,P64280	No				P64280					X2BH00,P64280										
NC_002945.3	Mycobrowser_v4	CDS	1207880	1208746	.	+	0	Mb1111	mca		Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase)	Mb1111, mca, len: 288 aa. Equivalent to Rv1082,len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 288 aa overlap). mca, mycothiol conjugate amidase (see citation below), equivalent to NP_302547.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (290 aa), FASTA scores: opt: 1737,E(): 0, (86.4% identity in 287 aa overlap); and similar to Q54358|X79146 lmbE protein from Streptomyces lincolnensis (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins deacetylase from Mycobacterium tuberculosis (303 aa),FASTA scores: opt: 411, E(): 9.4e-20, (35.8% identity in 299 aa overlap).	Q7VEZ7,A0A1R3XXA8	No	virulence, detoxification, adaptation			A0A1R3XXA8				IPR003737,IPR017811,IPR024078	Q7VEZ7					Rv1082		Rv1082			
NC_002945.3	Mycobrowser_v4	CDS	1212920	1215244	.	+	0	Mb1116	PE_PGRS21		pe-pgrs family protein pe_pgrs21	Mb1116, PE_PGRS21, len: 774 aa. Similar to Rv1087,len: 767 aa, from Mycobacterium tuberculosis strain H37Rv,(96.8% identity in 783 aa overlap). Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv1090|AL021897|MTV017_43 Mycobacterium tuberculosis H37Rv (853 aa), FASTA scores: opt: 2819, E(): 0, (59.8% identity in 860 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1 near C -terminus. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 3 bp (*-gcg) and 45 bp, and deletions of 18 bp and 9 bp (ggtggggcc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa).	Q7U0P7,A0A1R3XXN8	No				A0A1R3XXN8				IPR000084	Q7U0P7										
NC_002945.3	Mycobrowser_v4	CDS	1217850	1220402	.	+	0	Mb1121	PE_PGRS22		pe-pgrs family protein pe_pgrs22	Mb1121, PE_PGRS22, len: 850 aa. Equivalent to Rv1091, len: 853 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 853 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to Rv1087|AL021897|MTV017_39 Mycobacterium tuberculosis H37Rv (767 aa), FASTA scores: opt: 2819, E(): 0, (60.0% identity in 860 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (ccggcggca-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa).	Q7U0P1,A0A1R3XXC0	No				A0A1R3XXC0				IPR000084	Q7U0P1										
NC_002945.3	Mycobrowser_v4	CDS	1220620	1221558	.	-	0	Mb1122c	coaA		Probable pantothenate kinase coaA (Pantothenic acid kinase)	Mb1122c, coaA, len: 312 aa. Equivalent to Rv1092c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 312 aa overlap). Probable coaA,pantothenate kinase (EC 2.7.1.33), similar to many e.g. P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores :opt: 1079, E(): 0, (52.7% identity in 311 aa overlap). Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae (312 aa) (93.6% identity in 312 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.912. BELONGS TO THE PANTOTHENATE KINASE FAMILY.	X2BGW8,P63811,P63811	No				P63811					X2BGW8,P63811										
NC_002945.3	Mycobrowser_v4	CDS	1221946	1223226	.	+	0	Mb1123	glyA1		serine hydroxymethyltransferase 1 glya1	Mb1123, glyA1, len: 426 aa. Equivalent to Rv1093,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 426 aa overlap). Probable glyA1, serine hydroxymethyltransferase 1 (EC 2.1.2.1), equivalent to AL049491|MLCB1222_16 from Mycobacterium leprae (426 aa),FASTA score: (89.9 % identity in 426 aa overlap). Also similar to many e.g. P34895|GLYA_HYPME HYPHOMICROBIUM METHYLOVORUM (434 aa), FASTA scores: opt: 1492, E(): 0,(56.8% identity in 419 aa overlap); etc. BELONGS TO THE SHMT FAMILY. Note that previously known as glyA.	X2BH08,P59953,P59953	No				P59953					X2BH08,P59953										
NC_002945.3	Mycobrowser_v4	CDS	1223331	1224158	.	+	0	Mb1124	desA2		POSSIBLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA2 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE)	Mb1124, desA2, len: 275 aa. Equivalent to Rv1094,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 275 aa overlap). Possible desA2,acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.19.2), equivalent to AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa),FASTA score: (78.1% identity in 274 aa overlap). Also weakly similar to plant stearoyl-acyl carrier protein desaturases, and very similar to U49839|MTV043.16C|Rv0824c enzyme desA1 from Mycobacterium tuberculosis (338 aa),FASTA scores: opt: 525, E(): 8.5e-30, (32.2% identity in 270 aa overlap); and to U15182|MLU15182_32 acyl-carrier protein desaturase precursor from Mycobacterium leprae (338 aa), FASTA scores: opt: 506, E(): 1.9e-28, (34.1% identity in 261 aa overlap). TBparse score is 0.894.	Q7U0P0,A0A1R3XXD5	No				A0A1R3XXD5				IPR005067,IPR009078,IPR012348	Q7U0P0										
NC_002945.3	Mycobrowser_v4	CDS	1224369	1225670	.	+	0	Mb1125	phoH2		PROBABLE PHOH-LIKE PROTEIN PHOH2 (PHOSPHATE STARVATION-INDUCIBLE PROTEIN PSIH)	Mb1125, phoH2, len: 433 aa. Equivalent to Rv1095,len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 433 aa overlap). Probable phoH2,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein. Equivalent to AL049491 MLCB1222_14 Mycobacterium leprae (433 aa) (92.8% identity in 432 aa overlap). Similar to many proteins described as PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442 aa), FASTA scores: opt: 605, E(): 0, (40.1% identity in 444 aa overlap); or Mycobacterium tuberculosis Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352 aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOH FAMILY.	Q7U0N9,A0A1R3XXP8	No				A0A1R3XXP8				IPR002716,IPR003714,IPR027417	Q7U0N9										
NC_002945.3	Mycobrowser_v4	CDS	1227513	1228937	.	-	0	Mb1128c	fum		PROBABLE FUMARASE FUM (Fumarate hydratase)	Mb1128c, fum, len: 474 aa. Equivalent to Rv1098c,len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 474 aa overlap). Probable fum, fumarase (EC 4.2.1.2). Equivalent to AL049491|MLCB1222_11 Mycobacterium leprae (474 aa) (89.5 % identity in 467 aa overlap). Similar to many e.g. P14408|FUMH_RAT FUMARATE HYDRATASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus (507 aa), FASTA scores: opt: 1427, E(): 0, (52.3% identity in 461 aa overlap); and P05042|FUMC_ECOLI Fumarate hydratase class II from Escherichia coli (467 aa), FASTA scores: opt: 1355, E(): 0, (50.2% identity in 444 aa overlap). Contains PS00163 Fumarate lyases signature. TBparse score is 0.886.	X2BH10,Q7U0N6,Q7U0N6	No				Q7U0N6					X2BH10,Q7U0N6										
NC_002945.3	Mycobrowser_v4	CDS	1228968	1229954	.	-	0	Mb1129c	glpx		fructose 1,6-bisphosphatase glpx	Mb1129c, -, len: 328 aa. Equivalent to Rv1099c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 328 aa overlap). Conserved hypothetical protein, highly similar to P44811|GLPX_HAEIN GLPX PROTEIN HOMOLOG (believed to be involved in glycerol metabolism) (333 aa), FASTA scores: opt: 763, E():0, (46.2% identity in 327 aa overlap); and Q03224|YWJI_BACSU hypothetical protein from Bacillus subtilis (321aa ), FASTA scores: opt: 1092, E(): 0, (52.1% identity in 313 aa overlap). Equivalent to AL049491|MLCB1222_10 Mycobacterium leprae (355 aa), (93.0% identity in 328 aa overlap).	X2BHA1,Q7U0N5,Q7U0N5	No	intermediary metabolism and respiration			Q7U0N5					X2BHA1,Q7U0N5					Rv1099c		Rv1099c			
NC_002945.3	Mycobrowser_v4	CDS	1232031	1232342	.	-	0	Mb1132c	mazf3		toxin mazf3	Mb1132c, -, len: 103 aa. Equivalent to Rv1102c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 103 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protens e.g. Rv1942c|MTCY9F9_22 (109 aa),FASTA scores: opt: 158, E(): 3.6e-05, (33.3% identity in 93 aa overlap); Rv0659c|MTCI376_17 (102aa), opt: 140, E(): 0.00072, (40.6% identity in 69aa overlap); and Rv1495.	Q7U0N2,A0A1R3XZG6	No	virulence, detoxification, adaptation			A0A1R3XZG6				IPR003477,IPR011067	Q7U0N2					Rv1102c		Rv1102c			
NC_002945.3	Mycobrowser_v4	CDS	1232342	1232662	.	-	0	Mb1133c	maze3		possible antitoxin maze3	Mb1133c, -, len: 106 aa. Equivalent to Rv1103c,len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 106 aa overlap). Conserved hypothetical protein, similar to part of Mycobacterium tuberculosis hypothetical protein Rv2472|AL021246|MTV008_27 Mycobacterium tuberculosis (97 aa), FASTA score: opt: 135,E(): 0.0091, (45.8% identity in 72 aa overlap). TBparse score is 0.916.	Q7U0N1,A0A1R3XYC0	No	virulence, detoxification, adaptation			A0A1R3XYC0					Q7U0N1					Rv1103c		Rv1103c			
NC_002945.3	Mycobrowser_v4	CDS	1235337	1235594	.	-	0	Mb1137c	xseB		Probable exodeoxyribonuclease VII (small subunit) xseB (Exonuclease VII small subunit)	Mb1137c, xseB, len: 85 aa. Equivalent to Rv1107c,len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 85 aa overlap). Probable xseB,exonuclease VII small subunit (EC 3.1.11.6). Equivalent to AL049491|MLCB1222_6 Mycobacterium leprae (87 aa) (77.9% identity in 68 aa overlap). Similar to P43914|EX7S_HAEIN EXODEOXYRIBONUCLEASE SMALL SUBUNIT from H. influenzae (84 aa), FASTA scores: opt: 126, E(): 0.006, (37.3% identity in 67 aa overlap); and P22938|EX7S_ECOLI EXODEOXYRIBONUCLEASE SMALL SUBUNIT from Escherichia coli (79 aa), FASTA scores: opt: 125, E(): 0.0067, (39.7% identity in 58 aa overlap). BELONGS TO THE XSEB FAMILY.	X2BGY7,P67457,P67457	No				P67457					X2BGY7,P67457										
NC_002945.3	Mycobrowser_v4	CDS	1235584	1236831	.	-	0	Mb1138c	xseA		PROBABLE EXODEOXYRIBONUCLEASE VII (LARGE SUBUNIT) XSEA (EXONUCLEASE VII LARGE SUBUNIT)	Mb1138c, xseA, len: 415 aa. Equivalent to Rv1108c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 415 aa overlap). Probable xseA,exodeoxyribonuclease VII large subunit (EC 3.1.11.6) (see first citation below). Equivalent to AL049491|MLCB1222_5 Mycobacterium leprae (428 aa) (81.5% identity in 411 aa overlap). Similar to many e.g. P04994|EX7L_ECOLI exodeoxyribonuclease large subunit from Escherichia coli (456 aa), FASTA scores: opt: 581, E(): 1.6 e-30, (30.8% identity in 425 aa overlap); also similar to the exodeoxyribonuclease in Bacillus subtilis, H. influenzae and H. pylori. TBparse score is 0.890. BELONGS TO THE XSEA FAMILY.	X2BH15,P67448,P67448	No				P67448					X2BH15,P67448										
NC_002945.3	Mycobrowser_v4	CDS	1237556	1238563	.	+	0	Mb1140	lytB2		PROBABLE LYTB-RELATED PROTEIN LYTB2	Mb1140, lytB2, len: 335 aa. Equivalent to Rv1110,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 335 aa overlap). Probable lytB2,LytB-related protein, equivalent to AL049491|MLCB1222_3 from Mycobacterium leprae (335 aa), FASTA score: (82.9% identity in 333 aa overlap). Also similar to LytB proteins from many bacteria (appears to have N-terminal extension) e.g. P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB PROTEIN from Escherichia coli strains K12 and O157:H7 (316 aa),FASTA scores: opt: 1041, E():0, (52.4% identity in 309 aa overlap); etc. Also very similar to another LytB-related protein from Mycobacterium tuberculosis: LytB1|Rv3382c|MTV004.40c (329 aa), FASTA scores: opt: 975,E(): 0, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY.	X2BH45,P0A5I1,P0A5I1	No				P0A5I1					X2BH45,P0A5I1										
NC_002945.3	Mycobrowser_v4	CDS	2186604	2186981	.	-	0	Mb1978c	maze5		possible antitoxin maze5	Mb1978c, -, len: 125 aa. Equivalent to Rv1943c,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Conserved hypothetical protein, showing some similarity with Rv1946c|MTCY09F9.18|lppG possible conserved lipoprotein from Mycobacterium tuberculosis (150 aa), FASTA score: (71.4% identity in 28 aa overlap).	Q7TZ89,A0A1R3XZS3	No	virulence, detoxification, adaptation			A0A1R3XZS3					Q7TZ89					Rv1943c		Rv1943c			
NC_002945.3	Mycobrowser_v4	CDS	1245078	1246478	.	+	0	Mb1152	zwf1		PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF1 (G6PD)	Mb1152, zwf1, len: 466 aa. Equivalent to Rv1121,len: 466 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 466 aa overlap). Probable zwf1,glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), highly similar to many e.g. G6PD_E COLI|P22992 Escherichia coli (491 aa), FASTA scores: opt: 642, E(): 0, (35.8% identity in 478 aa overlap). Mycobacterium tuberculosis has two genes for ZWF, this one is highly divergent. BELONGS TO THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY. Note that previously known as zwf.	X2BH05,P0A587,P0A587	No	intermediary metabolism and respiration			P0A587					X2BH05,P0A587					Rv1121		Rv1121			
NC_002945.3	Mycobrowser_v4	CDS	1266458	1266826	.	-	0	Mb1169c	Mb1169c		HYPOTHETICAL PROTEIN	Mb1169c, -, len: 122 aa. Equivalent to Rv1137c,len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 122 aa overlap). Hypothetical unknown protein.	Q7U0K2,A0A1R3XXH5	No	conserved hypotheticals			A0A1R3XXH5					Q7U0K2					Rv1137c		Rv1137c			
NC_002945.3	Mycobrowser_v4	CDS	1246500	1247522	.	+	0	Mb1153	gnd2		probable 6-phosphogluconate dehydrogenase,decarboxylating gnd2	Mb1153, gnd2, len: 340 aa. Equivalent to Rv1122,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 340 aa overlap). Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44), highly similar to Q53917 6-PHOSPHOGLUCONATE DEHYDROGENASE from Streptomyces coelicolor (291 aa), fasta scores: opt: 431, E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive organisms. BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY.	Q7U0L7,A0A1R3XYE0	No	intermediary metabolism and respiration			A0A1R3XYE0				IPR004849,IPR006114,IPR006115,IPR008927,IPR013328,IPR016040	Q7U0L7					Rv1122		Rv1122			
NC_002945.3	Mycobrowser_v4	CDS	1247515	1248423	.	-	0	Mb1154c	bpoB		POSSIBLE PEROXIDASE BPOB (NON-HAEM PEROXIDASE)	Mb1154c, bpoB, len: 302 aa. Equivalent to Rv1123c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 302 aa overlap). Possible bpoB,peroxidase (non-haem peroxidase) (EC 1.11.1.-), with some similarity to a range of enzymes from several organisms including: DEH1_MORSP|Q01398 haloacetate dehalogenase (EC 3.8.1.3) from Moraxella sp. (294 aa), FASTA scores: opt: 201, E(): 2.1e-06, (35.8% identity in 134 aa overlap); and BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 (EC 1.11.1.-) from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 187, E(): 1.6e-05, (23.1% identity in 281 aa overlap). Similar to several other Mycobacterium tuberculosis proteins, probable epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c,Rv3171c, etc. Contains PS00216 Sugar transport proteins signature 1.	Q7U0L6,A0A1R3XXG7	No				A0A1R3XXG7					Q7U0L6										
NC_002945.3	Mycobrowser_v4	CDS	1248498	1249448	.	+	0	Mb1155	ephC		PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE)	Mb1155, ephC, len: 316 aa. Equivalent to Rv1124,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 316 aa overlap). Probable ephC, epoxide hydrolase (EC 3.3.2.3) (see citation below), similar to Q42566 epoxide hydrolase from Arabidopsis thaliana (321 aa), FASTA scores: opt: 298, E(): 8.2e-13, (27.6% identity in 333 aa overlap). Similar to other Mycobacterium tuberculosis epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3670, Rv3473c,etc.	Q7U0L5,A0A1R3XXS8	No	virulence, detoxification, adaptation			A0A1R3XXS8				IPR000639	Q7U0L5					Rv1124		Rv1124			
NC_002945.3	Mycobrowser_v4	CDS	1251303	1252775	.	-	0	Mb1158c	ppdK		PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK	Mb1158c, ppdK, len: 490 aa. Equivalent to Rv1127c,len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 490 aa overlap). Probable ppdK,Pyruvate, phosphate dikinase (EC 2.7.9.1). Equivalent (but shorter) to Z94723|MLCB33_16 ppdK from Mycobacterium leprae (601 aa) (71.8% identity in 478 aa overlap). Highly similar to N-terminus of PODK_CLOSY|P22983 pyruvate,phosphate dikinase from Clostridium symbiosum (873 aa),FASTA scores: opt: 786, E(): 0, (37.4% identity in 514 aa overlap).	Q7U0L2,A0A1R3XXF3	No				A0A1R3XXF3				IPR002192,IPR008279,IPR010121,IPR013815,IPR013816	Q7U0L2										
NC_002945.3	Mycobrowser_v4	CDS	1255926	1257506	.	+	0	Mb1161	prpd		possible methylcitrate dehydratase prpd	Mb1161, -, len: 526 aa. Equivalent to Rv1130, len: 526 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 526 aa overlap). Conserved hypothetical protein, some similarity to AP000063|AP000063_192 hypothetical protein from Aeropyrum pernix (479 aa), FASTA scores: opt: 717, E(): 0, (34.3% identity in 443 a a overlap), and to PRPD_ECOLI|P77243 prpd protein from Escherichia coli (483aa), FASTA scores: opt: 234, E(): 3.3e-08, (27.0% identity in 429 aa overlap).	Q7U0K9,A0A1R3XXG0	No	intermediary metabolism and respiration			A0A1R3XXG0				IPR005656	Q7U0K9					Rv1130		Rv1130			
NC_002945.3	Mycobrowser_v4	CDS	1257503	1258684	.	+	0	Mb1162	prpc		probable methylcitrate synthase prpc	Mb1162, gltA1, len: 393 aa. Equivalent to Rv1131,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Probable gltA1, citrate synthase 1 (EC 4.1.3.7), highly similar to CISY_MYCSM|P26491 citrate synthase from Mycobacterium smegmatis (375 aa), FASTA scores: opt:1942, E(): 0, (80.0% identity in 375 aa overlap). Also similar to two other M. tuberculosis citrate synthases, Rv0896c|MTCY31.24|gltA2 (431 aa), FASTA score: (33.1% identity in 381 aa overlap) and Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (31.8% identity in 371 aa overlap). Contains PS00480 Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FAMILY.	Q7U0K8,A0A1R3XZI5	No				A0A1R3XZI5				IPR002020,IPR011278,IPR016141,IPR016142,IPR016143,IPR019810,IPR024176	Q7U0K8										
NC_002945.3	Mycobrowser_v4	CDS	1269574	1270380	.	-	0	Mb1173c	echA11		PROBABLE ENOYL-COA HYDRATASE ECHA11 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb1173c, echA11, len: 268 aa. Equivalent to Rv1141c, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 268 aa overlap). Probable echA11, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. P24162|ECHH_RHOCA PROBABLE ENOYL-COA HYDRATASE from Rhodobacter capsulatus (257 aa); CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa), FASTA scores: opt: 513, E(): 1e-25, (36.1% identity in 249 aa overlap); etc. Also similarity with naphthoate synthases. Also highly similar to downstream ORF Rv1142c|MTCI65.09|echA10 PROBABLE ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (268 aa), FASTA scores: opt: 1225, E(): 0, (72.3% identity in 267 aa overlap).	Q7U0J8,A0A1R3XYF7	No	lipid metabolism			A0A1R3XYF7				IPR001753,IPR014748	Q7U0J8					Rv1141c		Rv1141c			
NC_002945.3	Mycobrowser_v4	CDS	1260438	1262717	.	-	0	Mb1164c	metE		PROBABLE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE METE (methionine synthase, vitamin-B12 independent isozyme)	Mb1164c, metE, len: 759 aa. Equivalent to Rv1133c,len: 759 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 759 aa overlap). Probable metE,5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14), highly similar to others e.g. METE_ECOLI|P25665 Escherichia coli (752 aa), FASTA scores: opt: 2251, E(): 0, (48.1% identity in 756 aa overlap). Equivalent to Z94723|MLCB33_14 metE from M. leprae (760 aa) (85.3% identity in 755 aa overlap). BELONGS TO THE VITAMIN-B12 INDEPENDENT METHIONINE SYNTHASE FAMILY.	X2BHF0,P65341,P65341	No				P65341					X2BHF0,P65341										
NC_002945.3	Mycobrowser_v4	CDS	1263643	1265499	.	-	0	Mb1166c	PPE16		ppe family protein ppe16	Mb1166c, PPE16, len: 618 aa. Equivalent to Rv1135c,len: 618 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 618 aa overlap). Member of the M. tuberculosis PPE family of glycine-rich proteins. Similar to Rv2356c (59.6% identity in 627 aa overlap); etc.	Q7U0K5,A0A1R3XXG8	No				A0A1R3XXG8				IPR000030,IPR002989	Q7U0K5										
NC_002945.3	Mycobrowser_v4	CDS	2193772	2194221	.	+	0	Mb1991	higa		possible antitoxin higa	Mb1991, -, len: 149 aa. Equivalent to Rv1956, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Possible transcriptional regulatory protein, contains probable helix-turn-helix motif at aa 52-73 (+4.78 SD).	Q7TZ76,A0A1R3Y0L8	No	virulence, detoxification, adaptation			A0A1R3Y0L8				IPR001387,IPR010982	Q7TZ76					Rv1956		Rv1956			
NC_002945.3	Mycobrowser_v4	CDS	1270523	1271329	.	-	0	Mb1174c	echA10		PROBABLE ENOYL-CoA HYDRATASE ECHA10 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)	Mb1174c, echA10, len: 268 aa. Equivalent to Rv1142c, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 268 aa overlap). Probable echA10, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa), FASTA scores: opt: 525, E(): 1.3e-26, (35.1% identity in 251 aa overlap); NP_420658.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (267 aa); NP_438092.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (263 aa); etc. Also similarity with naphthoate synthases. Also highly similar to upstream ORF Rv1141c|MTCI65.08c|echA11 PROBABLE ENOYL-CoA HYDRATASE from Mycobacterium tuberculosis (268 aa), FASTA score: opt: 1225, E(): 0, (72.3% identity in 267 aa overlap). TBparse score is 0.891.	Q7U0J7,A0A1R3XXI6	No	lipid metabolism			A0A1R3XXI6				IPR001753,IPR014748	Q7U0J7					Rv1142c		Rv1142c			
NC_002945.3	Mycobrowser_v4	CDS	1271433	1272515	.	+	0	Mb1175	mcr		PROBABLE ALPHA-METHYLACYL-COA RACEMASE MCR (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )	Mb1175, mcr, len: 360 aa. Equivalent to Rv1143,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable mcr,alpha-methylacyl-CoA racemase (EC 5.1.99.4). Strong similarity to other alpha-methylacyl-CoA racemases and also some similarity to L-carnitine dehydratase (EC 4.2.1.89) e.g. U89905|g1552373 methylacyl-CoA racemase alpha from Norway rat (361 aa), FASTA scores: opt: 1035,E():0, (47.2% identity in 339 aa overlap). Equivalent to (but longer than) Z94723|MLCB33_13 Mycobacterium leprae (253 aa) (85.3% identity in 245 aa overlap). Also similar to Mycobacterium tuberculosis putative racemases Rv0855,Rv1866, Rv3272.	Q7U0J6,A0A1R3XXU6	No	lipid metabolism			A0A1R3XXU6				IPR003673,IPR023606	Q7U0J6					Rv1143		Rv1143			
NC_002945.3	Mycobrowser_v4	CDS	2196911	2197183	.	-	0	Mb1997A	vapB35		Possible antitoxin VapB35	Mb1997A, len: 90 aa. Equivalent to Rv1962A len: 90 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB35,antitoxin,part of toxin-antitoxin (TA) operon with Rv1962c, see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. Rv3385c, Rv3407, Rv0626	X2BJ65,A0A1R3XZW6	No	virulence, detoxification, adaptation			A0A1R3XZW6					X2BJ65					Rv1962A		Rv1962A			
NC_002945.3	Mycobrowser_v4	CDS	1273794	1276139	.	+	0	Mb1177	mmpL13		probable conserved transmembrane transport protein mmpl13b	Mb1177, mmpL13, len: 781 aa. Equivalent to Rv1145 and Rv1146, len: 303 aa and 470 aa, from Mycobacterium tuberculosis strain H37Rv, (97.9% identity in 284 aa overlap and 100% identity in 470 aa overlap). Probable mmpL13A, conserved transmembrane transport protein (see citation below), member of RND superfamily, showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. MTCY987|g1781238 from Mycobacterium tuberculosis (962 aa), FASTA scores: opt: 213, E(): 1.9e-06, (28.0% identity in 296 aa overlap); etc. Strong similarity to U92075|MMU92075_5 hypothetical protein from Mycobacterium marinum (256 aa), FASTA scores: opt: 957,E(): 0, (57.6% identity in 257 aa overlap). Should continue as mmpL13B|Rv1146, but frameshift required. Sequence has been checked and is identical in M. tuberculosis strain CDC1551, and Mycobacterium bovis strain AF2122/97 ????. BELONGS TO THE MMPL FAMILY. Probable mmpL13B, conserved transmembrane transport protein (see citation below), member of RND superfamily,showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. Q53902|C40046 antibiotic transport-associated protein from Streptomyces coelicolor (711 aa), FASTA scores: opt: 193, E(): 2.1e-05,(28.9% identity in 394 aa overlap); etc. Could be in frame with previous ORF mmpL13A|Rv1145, but no sequence error apparent to account for this; sequence is identical in Mycobacterium tuberculosis strain CDC1551. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-a) leads to a single product.	Q7U0J4,A0A1R3XXH2	No	cell wall and cell processes			A0A1R3XXH2				IPR000731,IPR004869	Q7U0J4					Rv1145		Rv1145			
NC_002945.3	Mycobrowser_v4	CDS	1281370	1282218	.	-	0	Mb1184c	omt		PROBABLE O-METHYLTRANSFERASE OMT	Mb1184c, omt, len: 282 aa. Equivalent to Rv1153c,len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 282 aa overlap). Probable omt,O-methyltransferase (EC 2.1.1-), similar to TCMP_STRGA|P39887 Tetracenomycin polyketide synthesis O-methyltransferase tcmP (EC 2.1.1.-) from Streptomyces glaucescens (270 aa), FASTA scores: opt: 368, E(): 1.7e-17, (31.3% identity in 233 aa overlap).	Q7U0I9,A0A1R3XXJ6	No				A0A1R3XXJ6				IPR007213,IPR016874	Q7U0I9										
NC_002945.3	Mycobrowser_v4	CDS	1300139	1300681	.	-	0	Mb1200c	PPE17b		PPE FAMILY PROTEIN [SECOND PART]	Mb1200c, PPE17b, len: 181 aa. Equivalent to 3' end of Rv1168c, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1286364	1287659	.	+	0	Mb1190	pime		mannosyltransferase pime	Mb1190, -, len: 431 aa. Equivalent to Rv1159, len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 431 aa overlap). Conserved transmembrane protein, similar to others in Mycobacterium tuberculosis e.g. Rv2181|MTCY21D4.13 (560 aa), FASTA scores: opt: 172; E(): 0.00035, (25.0% identity in 332 aa overlap).	Q7U0I3,A0A1R3XXJ0	No	cell wall and cell processes			A0A1R3XXJ0				IPR018584	Q7U0I3					Rv1159		Rv1159			
NC_002945.3	Mycobrowser_v4	CDS	1287967	1288392	.	+	0	Mb1192	mutT2		PROBABLE MUTATOR PROTEIN MUTT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-OXO-DGTPASE)	Mb1192, mutT2, len: 141 aa. Equivalent to Rv1160,len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 141 aa overlap). Probable mutT, mutator protein or homolog (EC 3.6.1.-). More similar to D908197|g1742860 MutT homolog from Escherichia coli (135 aa), FASTA scores: opt: 226, E():1.1e-08, (39.7% identity in 116 aa overlap); than to MUTT_ECOLI|P08337 MUTATOR MUTT PROTEIN from Escherichia coli (129 aa), FASTA scores: opt: 180, E(): 1.2e-05, (27.1% identity in 129 aa overlap). Contains PS00893 mutT domain signature.	Q7U0I2,A0A1R3XYH8	No				A0A1R3XYH8				IPR000086,IPR015797,IPR020084,IPR020476	Q7U0I2										
NC_002945.3	Mycobrowser_v4	CDS	1288700	1292398	.	+	0	Mb1193	narG		respiratory nitrate reductase (alpha chain) narg	Mb1193, narG, len: 1232 aa. Equivalent to Rv1161,len: 1232 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1232 aa overlap). Probable narG,respiratory nitrate reductase alpha chain (EC 1.7.99.4). Similar to others e.g. NARG_BACSU NITRATEREDUCTASE ALPHA CHAIN from Bacillus subtilis (1228 aa), FASTA scores: opt: 4218, E(): 0, (50.3% identity in 1229 aa overlap); etc. Also highly similar to N-terminal part of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE from Mycobacterium tuberculosis (85.1% identity in 281 aa overlap). Contains prokaryotic molybdopterin oxidoreductase signatures 1 and 2 (PS00551, PS00490). BELONGS TO THE PROKARYOTIC MOLYBDOPTERIN-CONTAINING OXIDOREDUCTASE FAMILY.	Q7U0I1,A0A1R3XXK6	No				A0A1R3XXK6				IPR006468,IPR006655,IPR006656,IPR006657,IPR006963,IPR009010,IPR027467	Q7U0I1										
NC_002945.3	Mycobrowser_v4	CDS	1292437	1294113	.	+	0	Mb1194	narH		PROBABLE RESPIRATORY NITRATE REDUCTASE (BETA CHAIN) NARH	Mb1194, narH, len: 558 aa. Equivalent to Rv1162,len: 558 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 558 aa overlap). Probable narH,respiratory nitrate reductase beta chain (EC 1.7.99.4). Similar to others e.g. NARH_BACSU|P42176 NITRATE REDUCTASE BETA CHAIN from Bacillus subtilis (487 aa), FASTA scores: opt: 2049, E(): 0, (56.8% identity in 488 aa overlap); etc. Contains PS00190 cytochrome c family heme-binding site signature.	Q7U0I0,A0A1R3XXW6	No	intermediary metabolism and respiration			A0A1R3XXW6				IPR006547,IPR017896	Q7U0I0					Rv1162		Rv1162			
NC_002945.3	Mycobrowser_v4	CDS	1294170	1294775	.	+	0	Mb1195	narJ		PROBABLE RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) NARJ	Mb1195, narJ, len: 201 aa. Equivalent to Rv1163,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Probable narJ,respiratory nitrate reductase delta chain (EC 1.7.99.4). Similar to others e.g. P42178|NARJ_BACSU NITRATE REDUCTASE DELTA CHAIN from Bacillus subtilis (184 aa), FASTA scores: opt: 254, E(): 1.9e-10, (31.8% identity in 179 aa overlap); etc. Strong similarity to region from aa 260 -410 of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE from Mycobacterium tuberculosis (64.8% identity in 159 aa overlap).	Q7U0H9,A0A1R3XXJ7	No	intermediary metabolism and respiration			A0A1R3XXJ7				IPR003765,IPR020945	Q7U0H9					Rv1163		Rv1163			
NC_002945.3	Mycobrowser_v4	CDS	1294778	1295518	.	+	0	Mb1196	narI		PROBABLE RESPIRATORY NITRATE REDUCTASE (GAMMA CHAIN) NARI	Mb1196, narI, len: 246 aa. Equivalent to Rv1164,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 246 aa overlap). Probable narI,respiratory nitrate reductase gamma chain (EC 1.7.99.4). Similar to others e.g. NARI_BACSU|P42177 NITRATE REDUCTASE GAMMA CHAIN from Bacillus subtilis (223 aa), FASTA scores: opt: 652, E(): 0; (41.6% identity in 221 aa overlap); etc. Highly similar to C-terminal part of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE (GAMMA CHAIN) from Mycobacterium tuberculosis (68.6% identity in 239 aa overlap).	Q7U0H8,A0A1R3XXJ3	No	intermediary metabolism and respiration			A0A1R3XXJ3				IPR003816,IPR023234	Q7U0H8					Rv1164		Rv1164			
NC_002945.3	Mycobrowser_v4	CDS	1295540	1297426	.	+	0	Mb1197	typA		POSSIBLE GTP-BINDING TRANSLATION ELONGATION FACTOR TYPA (TYROSINE PHOSPHORYLATED PROTEIN A) (GTP-BINDING PROTEIN)	Mb1197, typA, len: 628 aa. Equivalent to Rv1165,len: 628 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 628 aa overlap). Possible typA (alternate gene name: bipA), GTP-binding translation elongation factor, similar to several e.g. P32132|TYPA_ECOLI|BIPA|B387 Escherichia coli (591 aa); YIHK_SYNY3|P72749 GTP-binding protein TYPA/BIPA homolog from synechocystis sp. (597 aa), FASTA scores: E(): 0,(46.9% identity in 610 aa overlap); and to elongation factor EF-G from many organims e.g. EFG_MICLU|P09952 micrococcus luteus (701 aa), FASTA scores: E(): 3e-24,(29.8% identity in 500 aa overlap). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, TYPA SUBFAMILY.	Q7U0H7,A0A1R3XXJ4	No	information pathways			A0A1R3XXJ4				IPR000640,IPR000795,IPR004161,IPR005225,IPR006298,IPR009000,IPR009022,IPR027417	Q7U0H7					Rv1165		Rv1165			
NC_002945.3	Mycobrowser_v4	CDS	1368707	1369102	.	+	0	Mb1256	tatB		Probable protein TatB	Mb1256, tatB, len: 131 aa. Equivalent to Rv1224,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 131 aa overlap). Probable tatB,component of twin-arginine translocation protein export system (see citation below for more information). Possible exported protein with hydrophobic stretch at N-terminus. Highly similar to Q49973|U15180 hypothetical protein U1756Y from Mycobacterium leprae (120 aa), FASTA scores: opt: 601, E(): 0, (73.3% identity in 131 aa overlap).	X2BHF1,Q7VEZ5,Q7VEZ5	No	cell wall and cell processes			Q7VEZ5					X2BHF1,Q7VEZ5					Rv1224		Rv1224			
NC_002945.3	Mycobrowser_v4	CDS	1297524	1299431	.	+	0	Mb1198	lpqW		probable conserved lipoprotein lpqw	Mb1198, lpqW, len: 635 aa. Equivalent to Rv1166,len: 635 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 635 aa overlap). Probable Lipoprotein LpqW, almost identical in part to G2384665|AF009358 Mycobacterium tuberculosis gene fragment ORFA2-898 (FRAGMENT) (59 aa) (93.9% identity in 49 aa overlap) (see citation below). Also similar to Rv1280c and Rv2585c. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U0H6,A0A1R3XXK3	No	cell wall and cell processes			A0A1R3XXK3				IPR000914	Q7U0H6					Rv1166		Rv1166			
NC_002945.3	Mycobrowser_v4	CDS	1300635	1301177	.	-	0	Mb1201c	PPE17a		PPE FAMILY PROTEIN [FIRST PART]	Mb1201c, PPE17a, len: 180 aa. Similar to 5' end of Rv1168c, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, (97.1% identity in 174 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b.	Q7U0H4,A0A1R3XZN0	No				A0A1R3XZN0				IPR000030	Q7U0H4										
NC_002945.3	Mycobrowser_v4	CDS	1301195	1301497	.	-	0	Mb1202c	lipx		pe family protein. possible lipase lipx.	Mb1202c, PE11, len: 100 aa. Equivalent to Rv1169c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 100 aa overlap). Member of the Mycobacterium tuberculosis PE family of proteins (see second citation below), e.g. O05297|Z93777|MTCI364.07 (99 aa), FASTA scores: opt: 209, E(): 1.6e-15, (37.4% identity in 99 aa overlap). Also simlar to the N-terminus of P77909|U76006 ESTERASE/LIPASE (EC 3.1.1.3) from Mycobacterium tuberculosis (437 aa), FASTA scores: opt: 193, E(): 4.4e-14, (37.2% identity in 94 aa overlap). Contains a helix-turn-helix motif from aa 88-109 (+2.76 SD).	Q7U0H3,A0A1R3XYI5	No				A0A1R3XYI5				IPR000084	Q7U0H3										
NC_002945.3	Mycobrowser_v4	CDS	1301677	1302588	.	+	0	Mb1203	mshB		N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase mshB (GlcNAc-Ins deacetylase)	Mb1203, mshB, len: 303 aa. Equivalent to Rv1170,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 303 aa overlap). mshB,N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyra noside Deacetylase (GlcNAc-Ins deacetylase) (see citation below), similar to Q54358|X79146 lmbE gene from Streptomyces lincolnensis (270 aa), FASTA scores: opt: 308, E(): 1.2e-15, (32.0% identity in 278 aa overlap). Also similar to Rv1082|MCA Mycothiol conjugate amidase from Mycobacterium tuberculosis (288 aa).	X2BHK1,Q7U0H2,Q7U0H2	No	intermediary metabolism and respiration			Q7U0H2					X2BHK1,Q7U0H2					Rv1170		Rv1170			
NC_002945.3	Mycobrowser_v4	CDS	1304304	1306874	.	+	0	Mb1206	fbiC		PROBABLE F420 BIOSYNTHESIS PROTEIN FBIC	Mb1206, fbiC, len: 856 aa. Equivalent to Rv1173,len: 856 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 856 aa overlap). Probable fbiC, F420 biosynthesis protein, equivalent to AAL91922|FBIC F420 biosynthesis protein fbiC from Mycobacterium bovis BCG (856 aa) (see citation below). The N-terminus (aa 80-420) is similar to Y446_METJA|Q57888 hypothetical protein mj0446 from methanococcus jannaschii (361 aa), FASTA scores: opt: 801, E(): 0, (41.2% identity in 337 aa overlap); and the C-terminus region (aa 530-856) is similar to e.g. YE31_METJA|Q58826 hypothetical protein mj1431 from methanococcus jannaschii (359 aa), FASTA scores: opt: 1089, E(): 0, (48.7% identity in 337 aa overlap).	X2BH81,Q7U0G9,Q7U0G9	No	intermediary metabolism and respiration			Q7U0G9					X2BH81,Q7U0G9					Rv1173		Rv1173			
NC_002945.3	Mycobrowser_v4	CDS	1306918	1307250	.	-	0	Mb1207c	tb8.4		low molecular weight t-cell antigen tb8.4	Mb1207c, -, len: 110 aa. Equivalent to Rv1174c,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Hypothetical unknown protein.	Q7U0G8,A0A1R3XXK5	No	cell wall and cell processes			A0A1R3XXK5				IPR016572	Q7U0G8					Rv1174c		Rv1174c			
NC_002945.3	Mycobrowser_v4	CDS	2235000	2235344	.	-	0	Mb2030c	fdxA		ferredoxin fdxa	Mb2030c, fdxA, len: 114 aa. Equivalent to Rv2007c,len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Probable fdxA,ferredoxin, similar to e.g. FER_MYCSM P00215 ferredoxin,Mycobacterium smegmatis (106 aa), FASTA scores, opt: 448,E(): 1 .6e-21, (58.7% identity in 109 aa overlap), also similar to Rv0886|MTCY31.14, (34.2% identity in 117 aa overlap) and fdxC|Rv1177.	X2BJ89,P64123,P64123	No				P64123					X2BJ89,P64123										
NC_002945.3	Mycobrowser_v4	CDS	1307451	1309475	.	-	0	Mb1208c	fadH		PROBABLE NADPH DEPENDENT 2,4-DIENOYL-COA REDUCTASE FADH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	Mb1208c, fadH, len: 674 aa. Equivalent to Rv1175c,len: 674 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 674 aa overlap). Probable fadH,NADPH-dependent 2,4-dienoyl-CoA reductase (EC 1.3.1.34),highly similar to others e.g. NP_251782.1|NC_002516 2,4-dienoyl-CoA reductase FadH1 from Pseudomonas aeruginosa (679 aa); CAC01564.1|AL391039 2,4-dienoyl-CoA reductase [NADPH] from Streptomyces coelicolor (671 aa); P42593|FADH_ECOLI 2,4-dienoyl-CoA reductase from Escherichia coli (671 aa), FASTA scores: opt: 2344, E(): 0, (53.1% identity in 671 aa overlap); etc. Also similar to Rv3359|MTV004.16 PUTATIVE OXIDOREDUCTASE from Mycobacterium tuberculosis (396 aa).	Q7U0G7,A0A1R3XXL3	No				A0A1R3XXL3				IPR001155,IPR001327,IPR013027,IPR013785,IPR023753	Q7U0G7										
NC_002945.3	Mycobrowser_v4	CDS	1310254	1310580	.	+	0	Mb1210	fdxC		PROBABLE FERREDOXIN FDXC	Mb1210, fdxC, len: 108 aa. Equivalent to Rv1177,len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 108 aa overlap). Probable fdxC,ferredoxin (EC 1.-.-.-), equivalent to NP_302047.1|NC_002677 ferredoxin from Mycobacterium leprae (108 aa); P00215|FER_MYCSM FERREDOXIN from Mycobacterium smegmatis (106 aa), FASTA scores: opt: 705, E(): 0, (87.7% identity in 106 aa overlap). Also highly similar to many e.g. JH0239 ferredoxin precursor from Saccharopolyspora erythraea (105 aa); P24496|FER_SACER FERREDOXIN from Saccharopolyspora erythraea (106 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. BELONGS TO THE BACTERIAL TYPE FERREDOXIN FAMILY. COFACTOR: BINDS 1 4FE-4S CLUSTER AND A 3FE-4S CLUSTER.	Q7U0G5,A0A1R3XXL0	No	intermediary metabolism and respiration			A0A1R3XXL0				IPR000813,IPR001450,IPR017896,IPR017900	Q7U0G5					Rv1177		Rv1177			
NC_002945.3	Mycobrowser_v4	CDS	445861	446250	.	-	0	Mb0374c	Mb0374c		HYPOTHETICAL PROTEIN	Mb0374c, -, len: 129 aa. Equivalent to Rv0367c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 129 aa overlap). Hypothetical unknown protein.	Q7U260,A0A1R3XV52	No	conserved hypotheticals			A0A1R3XV52				IPR021831	Q7U260					Rv0367c		Rv0367c			
NC_002945.3	Mycobrowser_v4	CDS	1314975	1321232	.	+	0	Mb1213	pks3		probable polyketide beta-ketoacyl synthase pks4	Mb1213, pks3, len: 2085 aa. Equivalent to Rv1180 and Rv1181, len: 488 aa and 1582 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 488 aa overlap and 99.9% identity in 1582 aa overlap). Probable polyketide beta-ketoacyl synthase (EC 2.3.1.-), similar to the N-terminus of many polyketide synthases e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from mycobacterium bovis (2110 aa), FASTA scores: opt: 2115,E(): 0, (66.5% identity in 472 aa overlap). Also similar to, and same length as P96284|Z83858|MTCY24G1.02 M. tuberculosis (496 aa), FASTA scores: opt: 1424, E(): 0,(50.9% identity in 444 aa overlap). Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site, also PS00606 Beta-ketoacyl synthases active site. BELONGS TO THE BETA-KETOACYL-ACP SYNTHASES FAMILY. Probable polyketide synthase, similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from mycobacterium bovis (2110 aa), FASTA scores: opt: 3518, E(): 0, (59.7% identity in 1614 aa overlap). Note that this similarity extends upstream of the first initiation codon into the upstream MTV005.16; however the stop codon at the end of MTV005.16 is present in at least 4 independent clones (BAC, cosmid and pUC) from the genome. The two CDS's may represent separate modules of the polyketide synthase. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis, a single base transversion (a-c) leads to a single product (similar to other organisms).	Q7U0G2,A0A1R3XXM6	No	lipid metabolism			A0A1R3XXM6				IPR001227,IPR009081,IPR011032,IPR013149,IPR013154,IPR013968,IPR014030,IPR014031,IPR014043,IPR016035,IPR016036,IPR016038,IPR016039,IPR016040,IPR018201,IPR020801,IPR020807,IPR020841,IPR020842,IPR020843	Q7U0G2					Rv1180		Rv1180			
NC_002945.3	Mycobrowser_v4	CDS	1321285	1322703	.	+	0	Mb1214	papA3		PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3	Mb1214, papA3, len: 472 aa. Equivalent to Rv1182,len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 472 aa overlap). Probable papA3,conserved polyketide synthase (PKS) associated protein,similar to other Mycobacterial hypothetical proteins e.g. Q49618|U00010 B1170_C1_180 from Mycobacterium leprae (471 aa), FASTA scores: opt: 2526, E(): 0, (75.6% identity in 471 aa overlap). Similar to other Mycobacterium tuberculosis hypothetical papA proteins; Rv3824c, Rv3820c,Rv1528c.	Q7U0G1,A0A1R3XXY4	No				A0A1R3XXY4				IPR001242	Q7U0G1										
NC_002945.3	Mycobrowser_v4	CDS	1322770	1325778	.	+	0	Mb1215	mmpL10		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL10	Mb1215, mmpL10, len: 1002 aa. Equivalent to Rv1183,len: 1002 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1002 aa overlap). Probable mmpL10, conserved transmembrane transport protein (see first citation below), member of RND superfamily, similar to many Mycobacterial hypothetical membrane proteins e.g. Q49619|U00010 from Mycobacterium leprae (1008 aa), FASTA scores: opt: 4545, E(): 0, (70.6% identity in 978 aa overlap); etc. BELONGS TO THE MMPL FAMILY.	X2BGW1,P65373,P65373	No				P65373					X2BGW1,P65373										
NC_002945.3	Mycobrowser_v4	CDS	1327026	1328762	.	-	0	Mb1217c	fadD21		probable fatty-acid-amp ligase fadd21 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb1217c, fadD21, len: 578 aa. Equivalent to Rv1185c, len: 578 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 578 aa overlap). Probable fadD21, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to several from Mycobacteria e.g. NP_301895.1|NC_002677 possible acyl-CoA synthase from Mycobacterium leprae (579 aa); P71495|U75685 ACYL-COA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8% identity in 579 aa overlap); etc. SEEMS TO BELONG TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	X2BH57,P63524,P63524	No	lipid metabolism			P63524					X2BH57,P63524					Rv1185c		Rv1185c			
NC_002945.3	Mycobrowser_v4	CDS	1330640	1332271	.	+	0	Mb1219	rocA		PROBABLE PYRROLINE-5-CARBOXYLATE DEHYDROGENASE ROCA	Mb1219, rocA, len: 543 aa. Equivalent to Rv1187,len: 543 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 543 aa overlap). Probable rocA,pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12),similar to many e.g. PUT2_HUMAN|P30038 human delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa),FASTA scores: opt: 1596, E():0, (46.0% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site.	Q7U0F8,A0A1R3XXL2	No	intermediary metabolism and respiration			A0A1R3XXL2				IPR005931,IPR015590,IPR016160,IPR016161,IPR016162,IPR016163	Q7U0F8					Rv1187		Rv1187			
NC_002945.3	Mycobrowser_v4	CDS	1342253	1342537	.	+	0	Mb1230	esxL		putative esat-6 like protein esxl (esat-6 like protein 4)	Mb1230, esxL, len: 94 aa. Equivalent to Rv1198,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 94 aa overlap). esxL, putative ESAT-6 likeprotein 4. Member of the ESAT-6 family with Rv3619c,Rv1037c, etc. Almost identical to MTCY10G2.12 (94 aa) (97.9% identity in 94 aa overlap) and MTCY98.022c (94 aa) (94.7% identity in 94 aa overlap). Highly similar to Q49946|U1756D Mycobacterium leprae (95 aa), FASTA scores: opt: 403, E(): 1.1e-22, (64.1% identity in 92 aa overlap).	X2BGY3,P59804	No	cell wall and cell processes			P59804					X2BGY3					Rv1198		Rv1198			
NC_002945.3	Mycobrowser_v4	CDS	1507003	1507323	.	+	0	Mb1379	mbtl		acyl carrier protein (acp) mbtl	Mb1379, -, len: 106 aa. Equivalent to Rv1344, len: 106 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 106 aa overlap). Possible acyl carrier protein, similar to others e.g. ACP_RHIME|P19372 Rhizobium meliloti (77 aa), FASTA scores: opt: 117, E(): 0.03,(29.9% identity in 67 aa overlap) and ACP_SYNY3|P20804 acyl carrier protein (acp) from Synechocystis sp (77 aa),FASTA scores: E(): 7.1e-05, (34.8% identity in 66 aa overlap). Also similar to Rv2244 and Rv0033 from Mycobacterium tuberculosis.	X2BHN6,P63453,P63453	No	lipid metabolism			P63453					X2BHN6,P63453					Rv1344		Rv1344			
NC_002945.3	Mycobrowser_v4	CDS	1333342	1334214	.	+	0	Mb1221	sigI		POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGI	Mb1221, sigI, len: 290 aa. Equivalent to Rv1189,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 290 aa overlap). Possible sigI,alternative RNA polymerase sigma factor (see citation below), similar to several e.g. O05767|U87307 extracytoplasmic function alternative sigma factor (sigE) from M. smegmatis (204 aa), FASTA scores: opt: 239, E(): 1.3e-09, (32.9% identity in 167 aa overlap).	Q7U0F6,A0A1R3XZQ9	No	information pathways			A0A1R3XZQ9				IPR007627,IPR011991,IPR013249,IPR013324,IPR013325,IPR014284	Q7U0F6					Rv1189		Rv1189			
NC_002945.3	Mycobrowser_v4	CDS	1337044	1338465	.	+	0	Mb1225	fadD36		PROBABLE FATTY-ACID-COA LIGASE FADD36 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb1225, fadD36, len: 473 aa. Equivalent to Rv1193,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 473 aa overlap). Probable fadD36,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa), FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7U0F2,A0A1R3XXM7	No				A0A1R3XXM7				IPR000873,IPR020845,IPR025110	Q7U0F2										
NC_002945.3	Mycobrowser_v4	CDS	1340253	1340552	.	+	0	Mb1227	PE13		pe family protein pe13	Mb1227, PE13, len: 99 aa. Equivalent to Rv1195,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 99 aa overlap). Member of Mycobacterium tuberculosis PE family (see first citation below), e.g. Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kd protein (498 aa), FASTA scores: opt: 307, E(): 1.4e-12,(56.3% identity in 96 aa overlap), similar to MTCY21C12.10c (99 aa), FASTA scores: opt:295, E(): 1.9e-11, (51.5% identity in 97 aa overlap).	Q7U0F0,A0A1R3XXM5	No	PE/PPE			A0A1R3XXM5				IPR000084	Q7U0F0					Rv1195		Rv1195			
NC_002945.3	Mycobrowser_v4	CDS	1340599	1341771	.	+	0	Mb1228	PPE18		ppe family protein ppe18	Mb1228, PPE18, len: 390 aa. Equivalent to Rv1196,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 391 aa overlap). PPE18 (alternate gene name: mtb39a). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to others e.g. Y07P_MYCTU|Q11031 hypothetical 40.0 kDa protein cy02b10.25c (396 aa), FASTA scores: opt: 2124,E(): 0, (85.1% identity in 397 aa overlap). Note that expression of Rv1196 was demonstrated in lysates by immunodetection (see first citation below). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa).	Q7U0E9,A0A1R3XXN5	No				A0A1R3XXN5				IPR000030,IPR022171	Q7U0E9										
NC_002945.3	Mycobrowser_v4	CDS	1341906	1342202	.	+	0	Mb1229	esxK		esat-6 like protein esxk (esat-6 like protein 3)	Mb1229, esxK, len: 98 aa. Equivalent to Rv1197,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 98 aa overlap). esxK, putative ESAT-6 like protein 3. Member of M. tuberculosis hypothetical QILSS protein family with Rv1038c, etc. Almost identical to MTCY98.023c (98 aa) (99.0% identity in 98 aa overlap) and MTCY10G2.11 (98 aa), FASTA scores: opt: 643, E(): 0,(99.0% identity in 98 aa overlap); highly similar to Q49945|U1756C from Mycobacterium leprae (100 aa), FASTA scores: opt: 377, E(): 8e-21, (58.3% identity in 96 aa overlap). BELONGS TO THE ESAT6 FAMILY.	X2BGJ8,P0DOB1	No	cell wall and cell processes			P0DOB1					X2BGJ8					Rv1197		Rv1197			
NC_002945.3	Mycobrowser_v4	CDS	1345463	1346416	.	-	0	Mb1233c	dapd		tetrahydrodipicolinate n-succinyltransferase dapd	Mb1233c, -, len: 317 aa. Equivalent to Rv1201c,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 317 aa overlap). Probable transferase (EC 2.-.-.-). Highly similar to Q49948|U1756F Mycobacterium leprae (317 aa), FASTA scores: opt: 1776,E(): 0, (84.9% identity in 317 aa overlap), also Q46064 ORF3 protein from CORYNEBACTERIUM GLUTAMICUM (316 aa),FASTA scores: opt: 864, E(): 0, (44.1% identity in 311 aa overlap).	X2BHN4,Q7U0E7,Q7U0E7	No	intermediary metabolism and respiration			Q7U0E7					X2BHN4,Q7U0E7					Rv1201c		Rv1201c			
NC_002945.3	Mycobrowser_v4	CDS	1346507	1347571	.	+	0	Mb1234	dapE		PROBABLE SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE DAPE	Mb1234, dapE, len: 354 aa. Equivalent to Rv1202,len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 354 aa overlap). Probable dapE,succinyl-diaminopimelate desuccinylase (EC 3.5.1.18),similar to DAPE_CORGL|Q59284 succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum (369 aa),FASTA scores: opt: 1301, E(): 0, (55.7% identity in 359 aa overlap), highly similar to Q49949|U1756G (400 aa), FASTA scores: opt: 2045, E(): 0, (87.0% identity in 354 aa overlap).	Q7U0E6,A0A1R3XXZ9	No	intermediary metabolism and respiration			A0A1R3XXZ9				IPR001261,IPR002933,IPR010174,IPR011650	Q7U0E6					Rv1202		Rv1202			
NC_002945.3	Mycobrowser_v4	CDS	1385522	1385782	.	+	0	Mb1273	vapb33		possible antitoxin vapb33	Mb1273, -, len: 86 aa. Equivalent to Rv1241, len: 86 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 86 aa overlap). Conserved hypothetical protein, member of family of 16 hypothetical M. tuberculosis proteins including: Rv2871|Q10799|YS71_MYCTU HYPOTHETICAL 13.2 KD PROTEIN CY2 (124 aa), FASTA scores: opt: 172, E(): 9.5e-06, (37.2% identity in 86 aa overlap); Rv2132, Rv3321c, etc.	Q7U0B3,A0A1R3XXT0	No	virulence, detoxification, adaptation			A0A1R3XXT0					Q7U0B3					Rv1241		Rv1241			
NC_002945.3	Mycobrowser_v4	CDS	1350579	1352372	.	+	0	Mb1238	fadD6		PROBABLE FATTY-ACID-COA LIGASE FADD6 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb1238, fadD6, len: 597 aa. Equivalent to Rv1206,len: 597 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 597 aa overlap). Probable fadD6,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); Q60714 mouse fatty acid transport protein fatp (646 aa), FASTA scores: opt:712, E(): 0,(36.8% identity in 600 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7U0E2,A0A1R3XXP6	No				A0A1R3XXP6				IPR000873,IPR020845,IPR025110	Q7U0E2										
NC_002945.3	Mycobrowser_v4	CDS	1352438	1353394	.	+	0	Mb1239	folP2		dihydropteroate synthase 2 folp2 (dhps 2) (dihydropteroate pyrophosphorylase 2)	Mb1239, folP2, len: 318 aa. Equivalent to Rv1207,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 318 aa overlap). Probable folP2,Dihydropteroate synthase 2 (EC 2.5.1.15), similar to many e.g. DHPS_ECOLI|P26282 Escherichia coli (282 aa), FASTA scores: opt: 480, E(): 1.9e-22, (34.4% identity in 270 aa overlap). Contains PS00792 dihydropteroate synthase signature 1, PS00793 dihydropteroate synthase signature 2.	X2BHD4,P64140,P64140	No				P64140					X2BHD4,P64140										
NC_002945.3	Mycobrowser_v4	CDS	1353391	1354365	.	+	0	Mb1240	gpgs		probable glucosyl-3-phosphoglycerate synthase gpgs	Mb1240, -, len: 324 aa. Equivalent to Rv1208, len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 324 aa overlap). Conserved hypothetical protein, similar to Q49955|U1756L Mycobacterium leprae (318 aa), FASTA scores, opt: 1621, E(): 0, (80.5% identity in 318 aa overlap).	X2BGZ8,Q7U0E1,Q7U0E1	No	intermediary metabolism and respiration			Q7U0E1					X2BGZ8,Q7U0E1					Rv1208		Rv1208			
NC_002945.3	Mycobrowser_v4	CDS	1354769	1355383	.	+	0	Mb1242	tagA		probable dna-3-methyladenine glycosylase i taga (tag i) (3-methyladenine-dna glycosylase i, constitutive) (dna-3-methyladenine glycosidase i)	Mb1242, tagA, len: 204 aa. Equivalent to Rv1210,len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 204 aa overlap). Probable tagA,DNA-3-methyladenine glycosidase I (EC 3.2.2.20), similar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichia coli (187 aa), FASTA scores: opt: 530, E(): 1.3e-27, (44.2% identity in 190 aa overlap). Also similar to Q49957 Mycobacterium leprae cosmid B1756 (192 aa), FASTA scores: opt: 1042, E(): 0,(80.2% identity in 192 aa overlap).	Q7U0D9,A0A1R3XYM7	No	information pathways			A0A1R3XYM7				IPR004597,IPR005019,IPR011257	Q7U0D9					Rv1210		Rv1210			
NC_002945.3	Mycobrowser_v4	CDS	1355745	1356908	.	-	0	Mb1244c	glga		putative glycosyl transferase glga	Mb1244c, -, len: 387 aa. Equivalent to Rv1212c,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Putative glycosyl transferase (EC 2.-.-.-), highly similar to AJ243803|SCO243803_2 Putative glycosyl transferase from Streptomyces coelicolor (387 aa), FASTA scores: opt: 1344,E(): 0, (54.9% identity in 388 aa overlap). Also similar to MJ1607 probable hexosyltransferase (EC 2.4.1.-) from Methanococcus jannaschii (390 aa), FASTA scores: opt: 445,E(): 7.8e-23, (27.9% identity in 401 aa overlap). The region from aa 267-355 highly similar to Q49959 COSMID B1756 from Mycobacterium leprae (91 aa), FASTA scores,opt: 471, E(): 4.8e-25, (80.9% identity in 89 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein, Rv3032.	Q7U0D7,A0A1R3XY10	No	intermediary metabolism and respiration			A0A1R3XY10				IPR001296,IPR011875	Q7U0D7					Rv1212c		Rv1212c			
NC_002945.3	Mycobrowser_v4	CDS	1357083	1358297	.	+	0	Mb1245	glgC		glucose-1-phosphate adenylyltransferase glgc (adp-glucose synthase) (adp-glucose pyrophosphorylase)	Mb1245, glgC, len: 404 aa. Equivalent to Rv1213,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 404 aa overlap). Probable glgC,glucose-1-phosphate adenylyltransferase (EC 2.7.7.27),similar to many e.g. GLGC_ECOLI|P00584 Escherichia coli (430 aa), FASTA scores: opt: 1075, E(): 0, (40.3% identity in 407 aa overlap); highly similar to Q49961 GLGC from Mycobacterium leprae (419 aa), FASTA scores: opt: 2532,E(): 0, (92.6% identity in 404 aa overlap). BELONGS TO THE BACTERIAL AND PLANTS GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE FAMILY.	X2BH06,P64242,P64242	No	intermediary metabolism and respiration			P64242					X2BH06,P64242					Rv1213		Rv1213			
NC_002945.3	Mycobrowser_v4	CDS	1358493	1358867	.	-	0	Mb1246c	PE14		pe family protein pe14	Mb1246c, PE14, len: 124 aa. Equivalent to 5' end of Rv1214c, len: 110 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 68 aa overlap). Member of Mycobacterium tuberculosis PE family, appears to be frameshifted but sequence appears to be correct. The 5'-end is atypical as first 9 aa appear to be missing. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus.	Q7U0D6,A0A1R3XXP3	No				A0A1R3XXP3				IPR000084	Q7U0D6										
NC_002945.3	Mycobrowser_v4	CDS	1365655	1366428	.	+	0	Mb1253	sigE		ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGE	Mb1253, sigE, len: 257 aa. Equivalent to Rv1221,len: 257 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 257 aa overlap). sigE, alternative sigma factor of extracytoplasmic function (ECF) family (see citations below). Similar to many e.g. RPOE_HAEIN|P44790 RNA polymerase sigma-e factor from Haemophilus influenzae (189 aa), FASTA scores: opt: 247, E(): 3.4e-06, (28.5% identity in 186 aa overlap); etc. Also similar to MTCY07D11.03 rpoE from Mycobacterium tuberculosis (35.2% identity in 159 aa overlap). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Note that in Mycobacterium bovis BCG, the sigE gene is transcribed from two promoters, P1 and P2, and that these promoters were expressed at temperatures from 30-50 C.	Q7U0C9,A0A1R3XXR2	No	information pathways			A0A1R3XXR2				IPR007627,IPR011991,IPR013249,IPR013324,IPR013325,IPR014284	Q7U0C9					Rv1221		Rv1221			
NC_002945.3	Mycobrowser_v4	CDS	1366586	1367050	.	+	0	Mb1254	rsea		anti-sigma factor rsea	Mb1254, -, len: 154 aa. Equivalent to Rv1222, len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Conserved hypothetical protein. Identical to O06290|MTU87242 (but shorter due to different start site chosen by proximity of RBS). Equivalent to O05736|U87308|MAU87308_2 hypothetical protein from Mycobacterium avium (133 aa), FASTA scores: opt: 644, E(): 7e-32, (86.2% identity in 109 aa overlap).	Q7U0C8,A0A1R3XY24	No	information pathways			A0A1R3XY24					Q7U0C8					Rv1222		Rv1222			
NC_002945.3	Mycobrowser_v4	CDS	1367119	1368705	.	+	0	Mb1255	htrA		PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN)	Mb1255, htrA, len: 528 aa. Equivalent to Rv1223,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 528 aa overlap). Probable htrA (alternate gene name: degP), serine protease precursor (EC 3.4.21.-), equivalent to U15180|MLU15180_31|Q49972|ML1078|HTRA POSSIBLE SERINE PROTEASE from Mycobacterium leprae (533 aa), FASTA scores: opt: 2777, E(): 4.1e-141, (81.6% identity in 533 aa overlap). Also similar to many others e.g. HTRA_ECOLI|P09376 protease do precursor from Escherichia coli (EC 3.4.21.-) (474 aa), FASTA scores: opt: 581, E(): 9.1e-27, (36.3% identity in 278 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Start changed since first submission (-21 aa).	Q7U0C7,A0A1R3XXQ7	No	intermediary metabolism and respiration			A0A1R3XXQ7				IPR001478,IPR001940,IPR009003	Q7U0C7					Rv1223		Rv1223			
NC_002945.3	Mycobrowser_v4	CDS	1373021	1374193	.	-	0	Mb1261c	mrp		PROBABLE MRP-RELATED PROTEIN MRP	Mb1261c, mrp, len: 390 aa. Equivalent to Rv1229c,len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 390 aa overlap). Probable Mrp protein,similar to others e.g. MRP_ECOLI|P21590 mrp protein from Escherichia coli (379 aa), FASTA scores: E(): 0, (34.1% identity in 355 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS01215 MRP Prosite domain. BELONGS TO THE MRP/NBP35 FAMILY OF ATP-BINDING PROTEINS.	X2BHF8,P65442,P65442	No				P65442					X2BHF8,P65442										
NC_002945.3	Mycobrowser_v4	CDS	2489863	2490324	.	-	0	Mb2262c	ahpE		probable peroxiredoxin ahpe	Mb2262c, ahpE, len: 153 aa. Equivalent to Rv2238c,len: 153 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 153 aa overlap). ahpE, peroxiredoxin. Similarity to many members of AHPC/TSA family e.g. sp|Q96291|BAS1_ARATH 2-CYS PEROXIREDOXIN BAS1 PRECURSOR (265 aa). FASTA score: opt: 275, E(): 2.7e-12; 35.0% identity in 143 aa overlap	X2BK87,P65689,P65689	No				P65689					X2BK87,P65689										
NC_002945.3	Mycobrowser_v4	CDS	1378768	1380174	.	+	0	Mb1267	lpqY		PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY	Mb1267, lpqY, len: 468 aa. Equivalent to Rv1235,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 468 aa overlap). Probable lpqY,sugar-binding lipoprotein component of sugar transport system (see citation below), equivalent to MLU1518034 protein u1756v from Mycobacterium leprae (469 aa), FASTA scores: opt: 2442, E(): 0, (77.4% identity in 470 aa overlap). Also similar to P18815|MALE_ENTAE MALTOSE-BINDING PERIPLASMIC PROTEIN from Enterobacter aerogenes (396 aa), FASTA scores: opt: 193, E(): 2.3e-05,(24.2% identity in 297 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	I3NIF6,A0A1R3XXR4	No	cell wall and cell processes			A0A1R3XXR4				IPR006059	I3NIF6					Rv1235		Rv1235			
NC_002945.3	Mycobrowser_v4	CDS	1380171	1381094	.	+	0	Mb1268	sugA		PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA	Mb1268, sugA, len: 307 aa. Equivalent to Rv1236,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Probable sugA,sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to U15180|MLU1518035 protein malFM from Mycobacterium leprae (310 aa), FASTA scores: opt: 1566, E(): 0, (81.8% identity in 292 aa overlap). Also similar to numerous bacterial sugar transport system components. Also similar to Rv2316|MTCY3G12.18c from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 514, E(): 7.3e-27, (33.2% identity in 283 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.	Q7U0B7,A0A1R3XXS7	No	cell wall and cell processes			A0A1R3XXS7				IPR000515	Q7U0B7					Rv1236		Rv1236			
NC_002945.3	Mycobrowser_v4	CDS	1381099	1381923	.	+	0	Mb1269	sugB		PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB	Mb1269, sugB, len: 274 aa. Equivalent to Rv1237,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Probable sugB,sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to U15180|MLU1518036 protein MalGM from Mycobacterium leprae (296 aa), FASTA scores: opt: 1571, E(): 0, (89.8% identity in 274 aa overlap). Also similar to numerous bacterial sugar transport protein. Related to Rv2834c|MTCY16B7.08 from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 370, E(): 2.4e-17, (26.8% identity in 269 aa overlap).	Q7U0B6,A0A1R3XXR5	No	cell wall and cell processes			A0A1R3XXR5				IPR000515	Q7U0B6					Rv1237		Rv1237			
NC_002945.3	Mycobrowser_v4	CDS	1381928	1383109	.	+	0	Mb1270	sugC		PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC	Mb1270, sugC, len: 393 aa. Equivalent to Rv1238,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 393 aa overlap). Probable sugC,sugar-transport ATP-binding protein ABC transporter (see citation below). Highly similar to U15180 protein ugpC from Mycobacterium leprae (392 aa), FASTA score: opt: 2007, E(): 0, (79.9% identity in 389 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7U0B5,A0A1R3XXS2	No	cell wall and cell processes			A0A1R3XXS2				IPR003439,IPR003593,IPR008995,IPR012340,IPR017871,IPR027417	Q7U0B5					Rv1238		Rv1238			
NC_002945.3	Mycobrowser_v4	CDS	1383186	1384286	.	-	0	Mb1271c	corA		POSSIBLE MAGNESIUM AND COBALT TRANSPORT TRANSMEMBRANE PROTEIN CORA	Mb1271c, corA, len: 366 aa. Equivalent to Rv1239c,len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 366 aa overlap). Possible corA,magnesium and cobalt transport transmembrane protein,highly similar to U15180 corA protein from Mycobacterium leprae (373 aa), FASTA scores: opt: 1985, E(): 0, (79.1% identity in 369 aa overlap). Also similar to various CorA proteins of Gram negative bacteria e.g. P27841|CORA_ECOLI|B3816|Z5333|ECS4746 Magnesium and cobalt transport protein from Escherichia coli strains K12 and O157:H7 (316 aa), FASTA scores: opt: 236, E(): 8e-08,(24.5% identity in 306 aa overlap); etc. SEEMS TO BELONG TO THE MIT FAMILY.	Q7U0B4,A0A1R3XZW9	No				A0A1R3XZW9				IPR002523,IPR004488	Q7U0B4										
NC_002945.3	Mycobrowser_v4	CDS	1384457	1385446	.	+	0	Mb1272	mdh		PROBABLE MALATE DEHYDROGENASE MDH	Mb1272, mdh, len: 329 aa. Equivalent to Rv1240,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 329 aa overlap). Probable mdh, Malate dehydrogenase (EC 1.1.1.37). Most similar to P50917|MDH_MYCLE MALATE DEHYDROGENASE from Mycobacterium leprae (329 aa), FASTA scores: opt: 1887, E(): 0, (89.1% identity in 329 aa overlap). Contains PS00068 Malate dehydrogenase active site signature. BELONGS TO THE LDH FAMILY. MDH SUBFAMILY.	X2BH84,P0A5J7,P0A5J7	No	intermediary metabolism and respiration			P0A5J7					X2BH84,P0A5J7					Rv1240		Rv1240			
NC_002945.3	Mycobrowser_v4	CDS	1386233	1387921	.	-	0	Mb1275c	PE_PGRS23		pe-pgrs family protein pe_pgrs23	Mb1275c, PE_PGRS23, len: 562 aa. Equivalent to Rv1243c, len: 562 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 562 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins.	Q7U0B1,A0A1R3XXS6	No				A0A1R3XXS6				IPR000084	Q7U0B1										
NC_002945.3	Mycobrowser_v4	CDS	1390601	1394296	.	-	0	Mb1280c	sucA		Multifunctional alpha-ketoglutarate metabolic enzyme	Mb1280c, len: 1231 aa. Equivalent to Rv1248c len: 1231 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 1231 aa overlap). Multifunctional alpha-ketoglutarate metabolic enzyme, highly similar to D84102 Corynebacterium glutamicum (1257 aa), FASTA scores: opt: 4418, E(): 0, (59.4% identity in 1223 aa overlap). Cofactor: thiamine diphosphate. Start changed since first submission (+17 aa).	X2BH56,Q7U0A6,Q7U0A6	No	intermediary metabolism and respiration			Q7U0A6					X2BH56,Q7U0A6					Rv1248c		Rv1248c			
NC_002945.3	Mycobrowser_v4	CDS	1388101	1388961	.	+	0	Mb1276	lpqZ		probable lipoprotein lpqz	Mb1276, lpqZ, len: 286 aa. Equivalent to Rv1244,len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 286 aa overlap). Probable lipoprotein lpqZ, equivalent to U15180|MLU1518042 protein u1756x from Mycobacterium leprae (228 aa), FASTA scores: opt: 1039,E(): 0, (72.5% identity in 229 aa overlap). Similar to M. tuberculosis hypothetical protein Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U0B0,A0A1R3XXS3	No	cell wall and cell processes			A0A1R3XXS3				IPR007210	Q7U0B0					Rv1244		Rv1244			
NC_002945.3	Mycobrowser_v4	CDS	1446077	1447420	.	+	0	Mb1325	lysA		diaminopimelate decarboxylase lysa (dap decarboxylase)	Mb1325, lysA, len: 447 aa. Equivalent to Rv1293,len: 447 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 447 aa overlap). Probable lysA,diaminopimelate decarboxylase (EC 4.1.1.20) (see citation below), almost identical to DCDA_MYCTU|P31848. Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site, PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. BELONGS TO FAMILY 2 OF ORNITHINE, DAP, AND ARGININE DECARBOXYLASES.	X2BHB0,P0A5M5,P0A5M5	No	intermediary metabolism and respiration			P0A5M5					X2BHB0,P0A5M5					Rv1293		Rv1293			
NC_002945.3	Mycobrowser_v4	CDS	1389929	1390222	.	-	0	Mb1278c	rele		toxin rele	Mb1278c, -, len: 97 aa. Equivalent to Rv1246c, len: 97 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 97 aa overlap). Conserved hypothetical protein, highly similar to Rv2866|MTV003.12 hypothetical Mycobacterium tuberculosis protein (87 aa), FASTA scores: opt: 290, E(): 3.9e-24, (54.1% identity in 85 aa overlap).	Q7U0A8,A0A1R3XXT8	No	virulence, detoxification, adaptation			A0A1R3XXT8				IPR007712	Q7U0A8					Rv1246c		Rv1246c			
NC_002945.3	Mycobrowser_v4	CDS	1390219	1390488	.	-	0	Mb1279c	relb		antitoxin relb	Mb1279c, -, len: 89 aa. Equivalent to Rv1247c, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 89 aa overlap). Conserved hypothetical protein, some similarity to hypothetical proteins including Mycobacterium tuberculosis proteins Rv2865|MTV003.11 (93 aa), FASTA scores: opt: 249, E(): 5.4e-13, (44.2% identity in 86 aa overlap); Rv0268|Z86089|P95225 (169 aa) opt: 125, E(): 0.0089,(41.8% identity in 55 aa overlap); etc. and AE000293|ECAE0002933 from Escherichia coli (92 aa), FASTA scores: opt: 127, E(): 0.0038, (29.3% identity in 82 aa overlap).	Q7U0A7,A0A1R3XXS5	No	virulence, detoxification, adaptation			A0A1R3XXS5				IPR006442	Q7U0A7					Rv1247c		Rv1247c			
NC_002945.3	Mycobrowser_v4	CDS	1400540	1401148	.	-	0	Mb1284c	lprE		PROBABLE LIPOPROTEIN LPRE	Mb1284c, lprE, len: 202 aa. Equivalent to Rv1252c,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 202 aa overlap). Probable lipoprotein lprE, some similarity to Mycobacterium tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA scores: E(): 7e-05, (29.5% identity in 200 aa overlap). Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).	X2BHG1,P65313,P65313	No				P65313					X2BHG1,P65313										
NC_002945.3	Mycobrowser_v4	CDS	1401214	1402905	.	+	0	Mb1285	deaD		PROBABLE COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG DEAD (ATP-dependent RNA helicase deaD homolog)	Mb1285, deaD, len: 563 aa. Equivalent to Rv1253,len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 563 aa overlap). Probable Dead,Cold-shock DEAD-box protein A homolog, similar to many e.g. DEAD_ECOLI|P23304 Escherichia coli (646 aa), FASTA scores: opt: 1490, E(): 0, (46.7% identity in 578 aa overlap); similar to Mycobacterium tuberculosis Rv3211. Contains PS00017 ATP/GTP-binding site motif A, PS00039 DEAD-box subfamily ATP-dependent helicases signature. BELONGS TO THE DEAD BOX FAMILY HELICASE.	Q7U0A2,A0A1R3XXT6	No	information pathways			A0A1R3XXT6				IPR000629,IPR001650,IPR005580,IPR011545,IPR014001,IPR014014,IPR027417,IPR028618	Q7U0A2					Rv1253		Rv1253			
NC_002945.3	Mycobrowser_v4	CDS	2193218	2193730	.	+	0	Mb1990	higb		possible toxin higb	Mb1990, -, len: 170 aa. Equivalent to Rv1955, len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 170 aa overlap). Hypothetical unknown protein, start overlaps another ORF, Rv1954c (MTCY09F9.10).	Q7TZ77,A0A1R3Y1X7	No	virulence, detoxification, adaptation			A0A1R3Y1X7				IPR009241	Q7TZ77					Rv1955		Rv1955			
NC_002945.3	Mycobrowser_v4	CDS	1408667	1410055	.	+	0	Mb1294	amiB2		PROBABLE AMIDASE AMIB2 (AMINOHYDROLASE)	Mb1294, amiB2, len: 462 aa. Equivalent to Rv1263,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 462 aa overlap). Probable amiB2, amidase (EC 3.5.1.4). Similar to G1001278 hypothetical 54.3 kDa protein (506 aa), FASTA scores: opt: 767, E(): 7.6e-40,(32.8% identity in 461 aa overlap), also similar to G580673 rhodococcus enantiose lective amidase gene (462 aa), FASTA scores, opt: 668, E(): 7.4e-34, (33.5% identity in 484 aa overlap); and to NYLA_PSES8|P13398 6-aminohexanoate-cyclic-dimer hydrolase (492 aa), FASTA scores opt: 543, E(): 3.1e-26, (33.5% identity in 493 aa overlap). Also similar to MTCY274.19c (33.5% identity in 427 aa overlap). Similar to other putative amidases in M. tuberculosis e.g. Rv2363, Rv2888c, etc. Contains PS00017 ATP/GTP-binding site motif A. BELONGS TO THE AMIDASE FAMILY.	X2BHG8,P63493,P63493	No				P63493					X2BHG8,P63493										
NC_002945.3	Mycobrowser_v4	CDS	607300	607599	.	+	0	Mb0527	Mb0527		POSSIBLE TRANSMEMBRANE PROTEIN	Mb0527, -, len: 99 aa. Equivalent to Rv0514, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Possible transmembrane protein.	Q7U1V8,A0A1R3XXQ9	No	cell wall and cell processes			A0A1R3XXQ9					Q7U1V8					Rv0514		Rv0514			
NC_002945.3	Mycobrowser_v4	CDS	1412196	1413986	.	-	0	Mb1297c	pknH		PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKNH (PROTEIN KINASE H) (STPK H)	Mb1297c, pknH, len: 596 aa. Similar to Rv1266c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(93.0% identity in 627 aa overlap). Probable pknH,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to many e.g. PKN1_MYXXA|P33973 pkn1 (693 aa), FASTA scores: opt: 611,E(): 1.4e- 14, (29.7% identity in 492 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature; PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa).	X2BH99,Q7U095,Q7U095	No				Q7U095					X2BH99,Q7U095										
NC_002945.3	Mycobrowser_v4	CDS	1414327	1415493	.	-	0	Mb1298c	embR		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR	Mb1298c, embR, len: 388 aa. Equivalent to Rv1267c,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 388 aa overlap). Probable embR,regulatory protein (see citation below), similar to many e.g. AFSR_STRCO|P25941 regulatory protein AfsR from Streptomyces coelicolor (993 aa), FASTA scores: opt: 489,E(): 1e-25, (33.5% identity in 361 aa overlap); etc. BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS.	X2BHV0,P66800,P66800	No				P66800					X2BHV0,P66800										
NC_002945.3	Mycobrowser_v4	CDS	1417160	1417894	.	-	0	Mb1301c	lprA		possible lipoprotein lpra	Mb1301c, lprA, len: 244 aa. Equivalent to Rv1270c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 244 aa overlap). Putative lipoprotein lprA (Precursor). Similar to O32852|AJ000500 lipoprotein from Mycobacterium bovis (236 aa), fasta scores: E(): 5.2e-23, (35.1% identity in 245 aa overlap). Similar to M. tuberculosis lipoproteins: Rv1368, Rv1411c, Rv2945c. Contains probable N-terminal signal sequence.	X2BHL0,Q7U094,Q7U094	No				Q7U094					X2BHL0,Q7U094										
NC_002945.3	Mycobrowser_v4	CDS	1422343	1422900	.	+	0	Mb1305	lprB		possible lipoprotein lprb	Mb1305, lprB, len: 185 aa. Equivalent to Rv1274,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 185 aa overlap). Possible lipoprotein lprB, contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013) . Some similarity to Rv1275.	X2BH93,Q7U093,Q7U093	No	cell wall and cell processes			Q7U093					X2BH93,Q7U093					Rv1274		Rv1274			
NC_002945.3	Mycobrowser_v4	CDS	1422897	1423439	.	+	0	Mb1306	lprC		possible lipoprotein lprc	Mb1306, lprC, len: 180 aa. Equivalent to Rv1275,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 180 aa overlap). Possible lipoprotein lprC, contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Some similarity to Rv1274.	Q7U092,A0A1R3XXW9	No	cell wall and cell processes			A0A1R3XXW9				IPR024520	Q7U092					Rv1275		Rv1275			
NC_002945.3	Mycobrowser_v4	CDS	1503110	1503925	.	+	0	Mb1373	murI		PROBABLE GLUTAMATE RACEMASE MURI	Mb1373, murI, len: 271 aa. Equivalent to Rv1338,len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 271 aa overlap). Probable murI,glutamate racemase (EC 5.1.1.3), highly similar to many e.g. MURI_MYCLE|P46705 (272 aa), FASTA scores: opt: 1559,E(): 0, (88.9% identity in 271 aa overlap). Contains PS00924 Aspartate and glutamate racemases signature 2.	X2BI28,P63636,P63636	No	cell wall and cell processes			P63636					X2BI28,P63636					Rv1338		Rv1338			
NC_002945.3	Mycobrowser_v4	CDS	1429811	1431586	.	-	0	Mb1311c	oppA		PROBABLE PERIPLASMIC OLIGOPEPTIDE-BINDING LIPOPROTEIN OPPA	Mb1311c, oppA, len: 591 aa. Equivalent to Rv1280c,len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 591 aa overlap). Probable oppA,oligopeptide-binding lipoprotein component of peptide transport system (see citation below), sharing some similarity to other periplasmic solute binding proteins e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding protein from Salmonella typhimurium (542 aa), FASTA scores: E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also similar to Rv1166 and Rv2585c from Mycobacterium tuberculosis. Has possible N-terminal signal sequence and prokaryotic lipoprotein lipid attachment site (PS00013). BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 5.	X2BHM1,P66772,P66772	No				P66772					X2BHM1,P66772										
NC_002945.3	Mycobrowser_v4	CDS	1431579	1433417	.	-	0	Mb1312c	oppD		PROBABLE OLIGOPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER OPPD	Mb1312c, oppD, len: 612 aa. Equivalent to Rv1281c,len: 612 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 612 aa overlap). Probable oppD,oligopeptide-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. DPPD_BACSU|P26905 dipeptide transport ATP-binding protein from Bacillus subtilis (335 aa), FASTA scores: opt: 983,E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	X2BHC0,P63396,P63396	No				P63396					X2BHC0,P63396										
NC_002945.3	Mycobrowser_v4	CDS	1433414	1434289	.	-	0	Mb1313c	oppC		PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER OPPC	Mb1313c, oppC, len: 291 aa. Equivalent to Rv1282c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 291 aa overlap). Probable oppC,oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. OPPC_ECOLI|P77664 oligopeptide transport system permease from Escherichia coli (302 aa), FASTA scores: E(): 4.6e-33, (40.7% identity in 275 aa overlap); etc. Also similar to Rv3664c|DPPC probable peptide-transport integral membrane protein from Mycobacterium tuberculosis.	X2BHW2,P66965,P66965	No				P66965					X2BHW2,P66965										
NC_002945.3	Mycobrowser_v4	CDS	1434286	1435263	.	-	0	Mb1314c	oppB		PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER OPPB	Mb1314c, oppB, len: 325 aa. Equivalent to Rv1283c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 325 aa overlap). Probable oppB,oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide transport system permease protein from Escherichia coli (339 aa), FASTA scores: opt: 402, E(): 3.4e-20, (31.0% identity in 345 aa overlap); etc. Also similar to Rv3665c|DppB probable peptide-transport integral membrane protein from Mycobacterium tuberculosis. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.	X2BHI0,P66967,P66967	No				P66967					X2BHI0,P66967										
NC_002945.3	Mycobrowser_v4	CDS	1435470	1435961	.	+	0	Mb1315	cana		beta-carbonic anhydrase	Mb1315, -, len: 163 aa. Equivalent to Rv1284, len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 163 aa overlap). Conserved hypothetical protein, similar to AL109663|SC4A10.26 hypothetical protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 567, E(): 1.5e-32, (53.4% identity in 163 aa overla); shows some similarity to hypothetical protein from Methanobacterium thermoautotrophicum. Weak similarity to carbonic anhydrases e.g. U51624|MTU516242|P17582 Methanothermobacter thermautotrophicus (171 aa), FASTA score: opt: 305, E(): 1 .2e-14, (35.2% identity in 165 aa overlap).	X2BHA3,P64798,P64798	No	intermediary metabolism and respiration			P64798					X2BHA3,P64798					Rv1284		Rv1284			
NC_002945.3	Mycobrowser_v4	CDS	1436055	1437053	.	+	0	Mb1316	cysD		PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2 CYSD	Mb1316, cysD, len: 332 aa. Equivalent to Rv1285,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 332 aa overlap). Probable cysD, sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (see first citation below), homology suggests start site at aa 24 or 28, similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate transferase subunit 2 from Escherichia coli (302 aa),FASTA score: opt: 973, E():0, (52.5% identity in 303 aa overlap). Also similar to Mycobacterium tuberculosis Rv2392, 3'-phosphoadenylylsulfate reductase. BELONGS TO THE PAPS REDUCTASE FAMILY. CYSD SUBFAMILY. Thought to be differentially expressed within host cells (see third citation below).	X2BHM7,P65671,P65671	No	intermediary metabolism and respiration			P65671					X2BHM7,P65671					Rv1285		Rv1285			
NC_002945.3	Mycobrowser_v4	tRNA	1510763	1510846	.	+	0	leuW	leuW		tRNA-Leu	leuW, len: 84 nt. Equivalent to leuW, len: 84 nt,from Mycobacterium tuberculosis strain H37RV, (100.0% identity in 84 nt overlap). tRNA-Leu, anticodon tag.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1437053	1438897	.	+	0	Mb1317	cysN		PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC: SULFATE ADENYLTRANSFERASE (SUBUNIT 1) + ADENYLYLSULFATE KINASE	Mb1317, cysN, len: 614 aa. Equivalent to Rv1286,len: 614 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 614 aa overlap). Probable cysN/cysC bifunctional enzyme, sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) and Adenylylsulfate kinase (EC 2.7.1.25) (see first citation below), similar to CYSN_ECOLI|P23845 sulfate adenylate transferase subunit 1 from Escherichia coli (475 aa), FASTA scores: opt: 1291, E():0, (50.2% identity in 428 aa overlap). Contains 2 x PS00017 ATP/GTP-binding site motif A, PS00301 GTP-binding elongation factors signature.	Q7U089,A0A1R3XXW4	No	intermediary metabolism and respiration			A0A1R3XXW4				IPR000795,IPR002891,IPR004161,IPR009000,IPR009001,IPR011779,IPR027417	Q7U089					Rv1286		Rv1286			
NC_002945.3	Mycobrowser_v4	CDS	1459370	1459885	.	+	0	Mb1338	atpF		PROBABLE ATP SYNTHASE B CHAIN ATPF	Mb1338, atpF, len: 171 aa. Equivalent to Rv1306,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 171 aa overlap). Probable atpF, ATP synthase B chain (EC 3.6.3.14), highly similar to ATPF_MYCLE P45827 (170 aa), FASTA scores, opt: 802, E(): 0, (79.5% identity in 171 aa overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE -AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE B CHAIN FAMILY.	X2BHY3,P63657,P63657	No	intermediary metabolism and respiration			P63657					X2BHY3,P63657					Rv1306		Rv1306			
NC_002945.3	Mycobrowser_v4	CDS	1444428	1446080	.	+	0	Mb1324	argS		PROBABLE ARGINYL-TRNA SYNTHETASE ARGS (ARGRS) (Arginine--tRNA ligase)	Mb1324, argS, len: 550 aa. Equivalent to Rv1292,len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 550 aa overlap). Probable argS,Arginyl-tRNA synthetase (EC 6.1.1.19), highly similar to SYR_MYCLE|P45840 Mycobacterium leprae (550 aa), FASTA scores: opt: 3115, E(): 0, (84.9% identity in 550 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BHI6,P67570,P67570	No	information pathways			P67570					X2BHI6,P67570					Rv1292		Rv1292			
NC_002945.3	Mycobrowser_v4	CDS	1447424	1448749	.	+	0	Mb1326	thrA		PROBABLE HOMOSERINE DEHYDROGENASE THRA	Mb1326, thrA, len: 441 aa. Equivalent to Rv1294,len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 441 aa overlap). Probable thrA (hom),homoserine dehydrogenase (EC 1.1.1.3), highly similar to DHOM_MYCLE|P46806 from Mycobacterium leprae (441 aa),FASTA scores: opt: 2437, E():0, (89.5% identity in 438 aa overlap). Contains PS00017 ATP/GTP-binding site motif A; PS01042 Homoserine dehydrogenase signature. BELONGS TO THE HOMOSERINE DEHYDROGENASE FAMILY.	X2BHN7,P63630,P63630	No	intermediary metabolism and respiration			P63630					X2BHN7,P63630					Rv1294		Rv1294			
NC_002945.3	Mycobrowser_v4	CDS	1448746	1449828	.	+	0	Mb1327	thrC		threonine synthase thrc (ts)	Mb1327, thrC, len: 360 aa. Equivalent to Rv1295,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable thrC,threonine synthase (EC 4.2.3.1) (see first citation below), highly similar to THRC_MYCLE|P45837 Mycobacterium leprae (360 aa), FASTA scores: opt: 2202, E(): 0, (93.9% identity in 359 aa overlap). Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.	X2BHF4,P66903,P66903	No	intermediary metabolism and respiration			P66903					X2BHF4,P66903					Rv1295		Rv1295			
NC_002945.3	Mycobrowser_v4	CDS	1450046	1450996	.	+	0	Mb1328	thrB		PROBABLE HOMOSERINE KINASE THRB	Mb1328, thrB, len: 316 aa. Equivalent to Rv1296,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 316 aa overlap). Probable thrB,homoserine kinase (EC 2.7.1.39) (see citation below),highly similar to KHSE_MYCLE|P45836 from Mycobacterium leprae (314 aa), FASTA scores, opt: 1657, E(): 0, (82.0% identity in 311 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, and PS00627 GHMP kinases putative ATP-binding domain.	X2BHX2,P65225,P65225	No	intermediary metabolism and respiration			P65225					X2BHX2,P65225					Rv1296		Rv1296			
NC_002945.3	Mycobrowser_v4	CDS	1451253	1453061	.	+	0	Mb1329	rho		PROBABLE TRANSCRIPTION TERMINATION FACTOR RHO HOMOLOG	Mb1329, rho, len: 602 aa. Equivalent to Rv1297,len: 602 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 602 aa overlap). Probable rho,transcription termination factor homolog, highly similar to many e.g. RHO_MYCLE|P45835 Mycobacterium leprae (610 aa), FASTA scores: (81.5% identity in 612 aa overlap). CONTAINS 1 RNA RECOGNITION MOTIF (RRM).	X2BHJ0,P66029,P66029	No	information pathways			P66029					X2BHJ0,P66029					Rv1297		Rv1297			
NC_002945.3	Mycobrowser_v4	CDS	1453544	1454617	.	+	0	Mb1331	prfA		PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA (RF-1)	Mb1331, prfA, len: 357 aa. Equivalent to Rv1299,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 357 aa overlap). Probable prfA, peptide chain release factor 1 (rf-1), highly similar to many e.g. RF1_MYCLE|P45833 peptide chain release factor 1 (rf-1) from Mycobacterium leprae (357 aa), FASTA scores: opt: 2047, E(): 0, (89.3% identity in 356 aa overlap); also similar to Mycobacterium tuberculosis Rv3105c, prfB peptide chain release factor 2. Contains PS00745 Prokaryotic-type class I peptide chain release factors signature. BELONGS TO THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY.	X2BHP1,P66017,P66017	No	information pathways			P66017					X2BHP1,P66017					Rv1299		Rv1299			
NC_002945.3	Mycobrowser_v4	CDS	1454614	1455591	.	+	0	Mb1332	hemK		PROBABLE HEMK PROTEIN HOMOLOG HEMK	Mb1332, hemK, len: 325 aa. Equivalent to Rv1300,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). Probable hemK protein homolog (EC 2.1.1.-), homology suggests translation may start at aa 22, highly similar to many e.g. HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa), FASTA scores: opt: 936, E(): 0, (76.7% identity in 189 aa overlap). BELONGS TO THE HEMK FAMILY OF MODIFICATION METHYLASES.	Q7U086,A0A1R3XYA7	No	intermediary metabolism and respiration			A0A1R3XYA7				IPR002052,IPR004556,IPR019874	Q7U086					Rv1300		Rv1300			
NC_002945.3	Mycobrowser_v4	CDS	1456344	1457558	.	+	0	Mb1334	rfe		probable undecapaprenyl-phosphate alpha-n-acetylglucosaminyltransferase rfe (udp-glcnac transferase)	Mb1334, rfe, len: 404 aa. Equivalent to Rv1302,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 404 aa overlap). Putative rfe,undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-),equivalent to RFE_MYCLE|P45830 Mycobacterium leprae (398 aa), FASTA scores, opt: 2285, E(): 0, (89.2% identity in 398 aa overlap).	Q7U084,A0A1R3XXY8	No	cell wall and cell processes			A0A1R3XXY8				IPR000715,IPR003524	Q7U084					Rv1302		Rv1302			
NC_002945.3	Mycobrowser_v4	CDS	1458293	1459045	.	+	0	Mb1336	atpB		PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6)	Mb1336, atpB, len: 250 aa. Equivalent to Rv1304,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 250 aa overlap). Probable atpB, ATP synthase A chain (EC 3.6.3.14), highly similar to ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa), FASTA scores: opt: 1382, E(): 0, (84.0% identity in 250 aa overlap). Contains PS00449 ATP synthase A subunit signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS,CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3),BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE A CHAIN FAMILY.	X2BHP5,P63655,P63655	No	intermediary metabolism and respiration			P63655					X2BHP5,P63655					Rv1304		Rv1304			
NC_002945.3	Mycobrowser_v4	CDS	1459094	1459339	.	+	0	Mb1337	atpE		PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN)	Mb1337, atpE, len: 81 aa. Equivalent to Rv1305,len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 81 aa overlap). Probable atpE, ATP synthase C chain (EC 3.6.3.14), highly similar to P45828|ATPL_MYCLE Mycobacterium leprae (92.6% identity in 81 aa overlap). Contains PS00605 ATP synthase C subunit signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS,CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3),BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE C CHAIN FAMILY.	X2BHH4,P63692,P63692	No	intermediary metabolism and respiration			P63692					X2BHH4,P63692					Rv1305		Rv1305			
NC_002945.3	Mycobrowser_v4	CDS	1459892	1461232	.	+	0	Mb1339	atpH		PROBABLE ATP SYNTHASE DELTA CHAIN ATPH	Mb1339, atpH, len: 446 aa. Equivalent to Rv1307,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 446 aa overlap). Probable atpH, ATP synthase delta chain (EC 3.6.3.14). This protein is much longer than that of other bacterial delta chains, the C-terminal region is homologous to delta chains while the N-terminal region is similar to B/B' subunits e.g. ATPD_STRLI|P50008 ATP synthase delta chain from Streptomyces lividans (273 aa), FASTA scores: opt: 505,E(): 5.4e-23, (35.0% identity in 277 aa overlap); and ATPF_HAEIN|P43720 ATP synthase B chain (EC 3.6.1.34) from Haemophilus influenzae (156 aa), FASTA scores: opt: 216,E(): 1.2e-06, (26.1% identity in 153 aa overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE DELTA CHAIN FAMILY.	X2BHK0,P0A501,P0A501	No	intermediary metabolism and respiration			P0A501					X2BHK0,P0A501					Rv1307		Rv1307			
NC_002945.3	Mycobrowser_v4	CDS	1461277	1462926	.	+	0	Mb1340	atpA		PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA	Mb1340, atpA, len: 549 aa. Equivalent to Rv1308,len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 549 aa overlap). Probable atpA, ATP synthase alpha chain (EC 3.6.3.14), highly similar to ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa),FASTA scores: opt: 3233, E(): 0, (90.3% identity in 547 aa overlap). Contains PS00017 ATP/GTP-binding site motif A,PS00152 ATP synthase alpha and beta subunits signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY.	X2BHC1,P63674,P63674	No	intermediary metabolism and respiration			P63674					X2BHC1,P63674					Rv1308		Rv1308			
NC_002945.3	Mycobrowser_v4	CDS	1462933	1463850	.	+	0	Mb1341	atpG		PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG	Mb1341, atpG, len: 305 aa. Equivalent to Rv1309,len: 305 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 305 aa overlap). Probable atpG, ATP synthase gamma chain (EC 3.6.3.14), highly similar to ATPG_MYCLE|P45824 ATP synthase gamma chain from Mycobacterium leprae (298 aa), FASTA scores: opt: 1579,E():0, (83.9% identity in 305 aa overlap). Contains PS00153 ATP synthase gamma subunit signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE GAMMA CHAIN FAMILY.	X2BHP9,P63672,P63672	No	intermediary metabolism and respiration			P63672					X2BHP9,P63672					Rv1309		Rv1309			
NC_002945.3	Mycobrowser_v4	CDS	1463890	1465350	.	+	0	Mb1342	atpD		PROBABLE ATP SYNTHASE BETA CHAIN ATPD	Mb1342, atpD, len: 486 aa. Equivalent to Rv1310,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 486 aa overlap). Probable atpD, ATP synthase beta chain (EC 3.6.3.14), highly similar to ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA score: opt: 2916, E(): 0, (92.6% identity in 484 aa overlap). Contains PS00017 ATP/GTP-binding site motif A,PS00152 ATP synthase alpha and beta subunits signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY.	X2BHI4,P63678,P63678	No	intermediary metabolism and respiration			P63678					X2BHI4,P63678					Rv1310		Rv1310			
NC_002945.3	Mycobrowser_v4	CDS	1465364	1465729	.	+	0	Mb1343	atpC		PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC	Mb1343, atpC, len: 121 aa. Equivalent to Rv1311,len: 121 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 121 aa overlap). Probable atpC, ATP synthase epsilon chain (EC 3.6.3.14), highly similar to ATPE_MYCLE|P45822 Mycobacterium leprae (124 aa), FASTA scores: opt: 682, E(): 5.4e-40, (87.6% identity in 121 aa overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3),GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE EPSILON CHAIN FAMILY.	X2BHY8,P63663,P63663	No	intermediary metabolism and respiration			P63663					X2BHY8,P63663					Rv1311		Rv1311			
NC_002945.3	Mycobrowser_v4	CDS	732349	732600	.	+	0	Mb0652	Mb0652		unknown protein	Mb0652, -, len: 83 aa. Equivalent to Rv0634A, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Hypothetical unknown protein.	Q7U1K5,A0A1R3XVX5	No	conserved hypotheticals			A0A1R3XVX5				IPR019239	Q7U1K5					Rv0634A		Rv0634A			
NC_002945.3	Mycobrowser_v4	CDS	1468357	1469613	.	+	0	Mb1348	murA		PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA	Mb1348, murA, len: 418 aa. Equivalent to Rv1315,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 418 aa overlap). Probable murA,UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7), highly similar to many e.g. MURA_MYCLE|P45821 (418 aa), FASTA scores: opt: 2495, E(): 0, (96.2% identity in 396 aa overlap). BELONGS TO THE EPSP SYNTHASE FAMILY. MURA SUBFAMILY.	X2BHZ4,P0A5L3,P0A5L3	No	cell wall and cell processes			P0A5L3					X2BHZ4,P0A5L3					Rv1315		Rv1315			
NC_002945.3	Mycobrowser_v4	rRNA	1469882	1471418	.	+	0	rrs	rrs		ribosomal RNA 16S	rrs, len: 1537 nt. Equivalent to rrs, len: 1537 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1537 nt overlap). 16s rRNA gene.		No																			
NC_002945.3	Mycobrowser_v4	rRNA	1471694	1474831	.	+	0	rrl	rrl		ribosomal RNA 23S	rrl, len: 3138 nt. Equivalent to rrl, len: 3138 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 3138 nt overlap). 23S rRNA gene (approximate coordinates).		No																			
NC_002945.3	Mycobrowser_v4	rRNA	1474935	1475049	.	+	0	rrf	rrf		ribosomal RNA 5S	rrf, len: 115 nt. Equivalent to rrf, len: 115 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 115 nt overlap). 5S rRNA gene. Identical to Em_ba:MT5SRR, D10035 M.tuberculosis 5S rRNA, len: 116 nt.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1475169	1475666	.	-	0	Mb1349c	ogt		methylated-dna--protein-cysteine methyltransferase ogt (6-o-methylguanine-dna methyltransferase) (o-6-methylguanine-dna-alkyltransferase)	Mb1349c, ogt, len: 165 aa. Equivalent to Rv1316c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Probable ogt,methylated-dna--protein-cysteine methytransferase (EC 2.1.1.63), similar to many e.g. OGT_HAEIN|P44687 Haemophilus influenzae (190 aa), FASTA scores: opt: 405,E(): 6.5e-20, (41.9% identity in 155 aa overlap). Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.	X2BHK8,P0A697,P0A697	No				P0A697					X2BHK8,P0A697										
NC_002945.3	Mycobrowser_v4	CDS	1483897	1485066	.	+	0	Mb1358	fadA4		PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA4 (ACETOACETYL-COA THIOLASE)	Mb1358, fadA4, len: 389 aa. Equivalent to Rv1323,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 389 aa overlap). Probable fadA4,acetyl-CoA acetyltransferase (EC 2.3.1.9), equivalent to THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase from Mycobacterium leprae (393 aa), FASTA scores: opt: 2218, E(): 0, (87.0% identity in 392 aa overlap). Also highly similar to others e.g. CAB70629.1|AL137242 probable acetoacetyl-coA thiolase from Streptomyces coelicolor (401 aa); T51772 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) [validated] from Alcaligenes latus (392 aa); etc. Some homologies indicate ATA start codon. Contains PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiolases signature 2, and PS00099 Thiolases active site. BELONGS TO THE THIOLASE FAMILY.	X2BI07,P66927,P66927	No				P66927					X2BI07,P66927										
NC_002945.3	Mycobrowser_v4	CDS	1506578	1506958	.	-	0	Mb1378c	lprD		PROBABLE CONSERVED LIPOPROTEIN LPRD	Mb1378c, lprD, len: 126 aa. Equivalent to Rv1343c,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 126 aa overlap). Probable lprD,conserved lipoprotein, highly similar to G466928 Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA scores, opt: 704, E(): 7.5e-36, (78.4 % identity in 125 aa overlap). Has N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7U075,A0A1R3XY27	No				A0A1R3XY27					Q7U075										
NC_002945.3	Mycobrowser_v4	CDS	1614165	1614398	.	+	0	Mb1475	secG		probable protein-export membrane protein (translocase subunit) secg	Mb1475, secG, len: 77 aa. Equivalent to Rv1440,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 77 aa overlap). Probable protein-export membrane protein secG, similar to many e.g. P38388|SECG_MYCLE PROBABLE PROTEIN-EXPORT MEMBRANE (77 aa), FASTA scores: opt: 450, E(): 6.7e-24, (96.1% identity in 77 aa overlap). Start changed since original submission (-40 aa). PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c,SECE|Rv0638, SECF|Rv2586c, SECG AND SECY|Rv0732.	X2BI51,P66792,P66792	No	cell wall and cell processes			P66792					X2BI51,P66792					Rv1440		Rv1440			
NC_002945.3	Mycobrowser_v4	CDS	1475663	1476913	.	-	0	Mb1350c	alkAb		PUTATIVE ADA REGULATORY PROTEIN ALKAb [SECOND PART] (Regulatory protein of adaptative response) : Methylated-DNA--protein-cysteine methyltransferase (O-6-methylguanine-DNA alkyltransferase)	Mb1350c, alkAb, len: 416 aa. Equivalent to the 3' end of Rv1317c, len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 416 aa overlap). Putative alkA (alternate gene name: ada),regulatory protein (EC 2.1.1.63), similar to 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from Escherichia coli (282 aa), FASTA scores, opt: 437, E(): 8.6e-22, (32.8% identity in 293 aa overlap), also similar to other ada proteins e.g. ADA_SALTY|P26189 Salmonella typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9% identity in 156 aa overlap). Contains PS00041 Bacterial regulatory proteins, araC family signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb.	Q7U082,A0A1R3Y043	No				A0A1R3Y043				IPR003265,IPR003583,IPR009057,IPR010316,IPR011257,IPR018060,IPR018062,IPR023170	Q7U082										
NC_002945.3	Mycobrowser_v4	CDS	1476917	1477153	.	-	0	Mb1351c	alkAa		PUTATIVE ADA REGULATORY PROTEIN ALKAa [FIRST PART] (Regulatory protein of adaptative response) : Methylated-DNA--protein-cysteine methyltransferase (O-6-methylguanine-DNA alkyltransferase)	Mb1351c, alkAa, len: 78 aa. Equivalent to the 5' end of Rv1317c, len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 78 aa overlap). Putative alkA (alternate gene name: ada),regulatory protein (EC 2.1.1.63), similar to 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from Escherichia coli (282 aa), FASTA scores, opt: 437, E(): 8.6e-22, (32.8% identity in 293 aa overlap), also similar to other ada proteins e.g. ADA_SALTY|P26189 Salmonella typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9% identity in 156 aa overlap). Contains PS00041 Bacterial regulatory proteins, araC family signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb.	Q7U081,A0A1R3XYZ1	No				A0A1R3XYZ1				IPR004026	Q7U081										
NC_002945.3	Mycobrowser_v4	CDS	1549333	1549914	.	+	0	Mb1414	pyrR		PROBABLE PYRIMIDINE OPERON REGULATORY PROTEIN PYRR	Mb1414, pyrR, len: 193 aa. Equivalent to Rv1379,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 193 aa overlap). Probable pyrR,pyrimidine operon regulatory protein, similar to PYRR_BACCL|P41007 pyrimidine operon regulatory protein from Bacillus caldolyticus (179 aa), FASTA scores: opt: 544, E(): 1.1e-30, (54.2% identity in 179 aa overlap).	X2BHH2,P65942,P65942	No	regulatory proteins			P65942					X2BHH2,P65942					Rv1379		Rv1379			
NC_002945.3	Mycobrowser_v4	CDS	1486189	1488000	.	-	0	Mb1360c	PE_PGRS24		pe-pgrs family protein pe_pgrs24	Mb1360c, PE_PGRS24, len: 603 aa. Equivalent to Rv1325c, len: 603 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 603 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of ala-, gly-rich proteins, similar to many e.g. YQ04_MYCTU|P71933 hypothetical 63.1 kd glycine-rich protein (778 aa), FASTA scores: E(): 0, (52.3% identity in 724 aa overlap).	Q7U079,A0A1R3Y056	No				A0A1R3Y056				IPR000084	Q7U079										
NC_002945.3	Mycobrowser_v4	CDS	1488152	1490347	.	-	0	Mb1361c	glgB		1,4-alpha-glucan branching enzyme glgb (glycogen branching enzyme)	Mb1361c, glgB, len: 731 aa. Equivalent to Rv1326c,len: 731 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 731 aa overlap). Probable glgB,1,4-alpha-glucan branching enzyme (EC 2.4.1.18), similar to others e.g. GLGB_ECOLI|P07762 Escherichia coli (728 aa), FASTA scores: opt: 2330, E(): 0, (48.7% identity in 719 aa overlap). Similar to other Mycobacterium tuberculosis putative alpha-glucan branching enzymes Rv1562c, Rv1563c. BELONGS TO FAMILY OF 13 GLYCOSYL HYDROLASES, ALSO KNOWN AS THE ALPHA-AMYLASE FAMILY.	X2BHS4,P59816,P59816	No				P59816					X2BHS4,P59816										
NC_002945.3	Mycobrowser_v4	CDS	1490355	1492460	.	-	0	Mb1362c	glgE		PROBABLE GLUCANASE GLGE	Mb1362c, glgE, len: 701 aa. Equivalent to Rv1327c,len: 701 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 701 aa overlap). Probable glgE,glucanase, similar to AF172946|AF172946_2 putative glucanase GlgE from Mycobacterium smegmatis (697 aa),FASTA scores: opt: 3816, E(): 0, (78.5% identity in 692 aa overlap). Similar to putative alpha-amylases e.g. Q9L1K2 Streptomyces coelicolor (675 aa), FASTA scores: opt: 2243,E(): 7.4e-132, (54.2% identity in 684 aa overlap). Start changed since original submission (-36) based on similarity to GlgE of Mycobacterium smegmatis; previous start at position 1494531.	X2BHK7,P63532,P63532	No				P63532					X2BHK7,P63532										
NC_002945.3	Mycobrowser_v4	CDS	1492599	1495190	.	+	0	Mb1363	glgP		PROBABLE GLYCOGEN PHOSPHORYLASE GLGP	Mb1363, glgP, len: 863 aa. Equivalent to Rv1328,len: 863 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 863 aa overlap). Probable glgP,glycogen phosphorylase (EC 2.4.1.1), similar to many e.g. PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus influenzae (821 aa), FASTA scores: E(): 6.9e-08, (25.6% identity in 675 aa overlap). BELONGS TO THE GLYCOGEN PHOSPHORYLASE FAMILY.	X2BI15,Q7U078,Q7U078	No	intermediary metabolism and respiration			Q7U078					X2BI15,Q7U078					Rv1328		Rv1328			
NC_002945.3	Mycobrowser_v4	CDS	1495230	1497224	.	-	0	Mb1364c	dinG		probable atp-dependent helicase ding	Mb1364c, dinG, len: 664 aa. Equivalent to Rv1329c,len: 664 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 664 aa overlap). Probable dinG,ATP-dependent helicase homolog, similar to several e.g. DING_HAEIN|P44680 probable ATP-dependent helicase ding from Haemophilus influenzae (640 aa), FASTA scores: opt: 685, E(): 2.3e-38, (32.8% identity in 644 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.	X2BHM2,P64315,P64315	No				P64315					X2BHM2,P64315										
NC_002945.3	Mycobrowser_v4	CDS	1497248	1498594	.	-	0	Mb1365c	pncb1		nicotinic acid phosphoribosyltransferase pncb1	Mb1365c, -, len: 448 aa. Equivalent to Rv1330c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 448 aa overlap). Conserved hypothetical protein, similar to others and also several nicotinate phosphoribosyltransferases e.g. O32090 YUEK PROTEIN from Bacillus subtilis (490 aa), FASTA scores: E(): 8.6e-22,(37.9% identity in 369 aa overlap). Also similar to M. tuberculosis Rv0573c|MTV039.11c (38.0% identity in 437 aa overlap). Start changed since original submission based on similarity; previous start at position 1500740 (-61 aa).	Q7U077,A0A1R3XY18	No	intermediary metabolism and respiration			A0A1R3XY18				IPR002638,IPR006405,IPR007229	Q7U077					Rv1330c		Rv1330c			
NC_002945.3	Mycobrowser_v4	CDS	1501429	1502400	.	+	0	Mb1371	cysM		cysteine synthase b cysm (csase b) (o-phosphoserine sulfhydrylase b) (o-phosphoserine (thiol)-lyase b)	Mb1371, cysM, len: 323 aa. Equivalent to Rv1336,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 323 aa overlap). Probable cysM, cysteine synthase B (EC 4.2.99.8), similar to many e.g. CYSM_ECOLI|P16703 Escherichia coli (303 aa), FASTA scores: opt: 720, E(): 4.6e-40, (41.1% identity in 302 aa overlap). Also similar to other Mycobacterium tuberculosis cysteine synthase subunits e.g. Rv1077, Rv2334, Rv0848,etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY.	X2BHT6,P63874,P63874	No	intermediary metabolism and respiration			P63874					X2BHT6,P63874					Rv1336		Rv1336			
NC_002945.3	Mycobrowser_v4	CDS	1504790	1505569	.	+	0	Mb1375	rphA		PROBABLE RIBONUCLEASE RPHA (RNase PH) (tRNA nucleotidyltransferase)	Mb1375, rphA, len: 259 aa. Equivalent to Rv1340,len: 259 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 259 aa overlap). Probable rphA,Ribonuclease ph (EC 2.7.7.56), highly similar to others e.g. RNPH_MYCLE|P37939 from Mycobacterium leprae (259 aa),FASTA scores: opt: 1524, E(): 0, (88.8% identity in 259 aa overlap). BELONGS TO THE RNASE PH FAMILY.	X2BHE6,Q7U076,Q7U076	No	information pathways			Q7U076					X2BHE6,Q7U076					Rv1340		Rv1340			
NC_002945.3	Mycobrowser_v4	CDS	1507316	1508881	.	+	0	Mb1380	mbtm		probable fatty acyl-amp ligase mbtm	Mb1380, fadD33, len: 521 aa. Equivalent to Rv1345,len: 521 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 521 aa overlap). Possible fadD33,polyketide synthase, similar to N-terminus of T34918 polyketide synthase from Streptomyces coelicolor (2297 aa); and PKSJ_BACSU|P40806 putative polyketide biosynthesis protein from Bacillus subtilis (557 aa),FASTA scores: opt: 537, E(): 8.2e-27, (27.1% identity in 468 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis eg Rv1013|MTCI237.30|MTCY10G2.36c|pks16 PUTATIVE POLYKETIDE SYNTHASE (544 aa); etc.	X2BHE8,P0A4X9,P0A4X9	No				P0A4X9					X2BHE8,P0A4X9										
NC_002945.3	Mycobrowser_v4	CDS	1508881	1510041	.	+	0	Mb1381	mbtn		acyl-coa dehydrogenase mbtn	Mb1381, fadE14, len: 386 aa. Equivalent to Rv1346,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 386 aa overlap). Possible fadE14,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. NP_251579.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (386 aa); NP_036951.1|NM_012819|ACDL_RAT|P15650 acyl Coenzyme A dehydrogenase (long chain) from Rattus norvegicus (430 aa), FASTA scores: opt: 414, E(): 1.2e-18, (26.1% identity in 376 aa overlap); etc.	X2BHU7,P63432,P63432	No				P63432					X2BHU7,P63432										
NC_002945.3	Mycobrowser_v4	CDS	1510008	1510640	.	-	0	Mb1382c	mbtk		lysine n-acetyltransferase mbtk	Mb1382c, -, len: 210 aa. Equivalent to Rv1347c,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Conserved hypothetical protein, some similarity to the C-terminus of malonyl-coenzyme A carboxylases e.g. G545170 malonyl-coenzyme A carboxylase (417 aa), FASTA scores: opt: 392, E(): 4.9 e-20, (35.6% identity in 174 aa overlap).	X2BHM4,P64820,P64820	No	lipid metabolism			P64820					X2BHM4,P64820					Rv1347c		Rv1347c			
NC_002945.3	Mycobrowser_v4	CDS	1511082	1513661	.	+	0	Mb1383	irta		iron-regulated transporter irta	Mb1383, -, len: 859 aa. Equivalent to Rv1348, len: 859 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 859 aa overlap). Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), similar to HMT1_SCHPO|Q02592 heavy metal tolerance protein precursor from Schizosaccharomyces pombe (830 aa), FASTA scores: opt: 806, E(): 5.1e-39, (32.9% identity in 504 aa overlap); etc. Also similar to MTCY02B10.13 from Mycobacterium tuberculosis, FASTA score: (31.9% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	X2BI38,P63392,P63392	No	cell wall and cell processes			P63392					X2BI38,P63392					Rv1348		Rv1348			
NC_002945.3	Mycobrowser_v4	CDS	1513658	1515397	.	+	0	Mb1384	irtb		iron-regulated transporter irtb	Mb1384, -, len: 579 aa. Equivalent to Rv1349, len: 579 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 579 aa overlap). Probable drugs-transport transmembrane ATP binding protein ABC transporter (see citation below), most similar to YWJA_BACSU|P45861 hypothetical ABC transporter from Bacillus subtilis (575 aa), FASTA scores: opt: 721, E(): 1.8e-35, (28.9% identity in 567 aa overlap); etc. Also similar to MTCY02B10.12 from Mycobacterium tuberculosis,FASTA score: (31.9% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	X2BHN8,P63394,P63394	No	cell wall and cell processes			P63394					X2BHN8,P63394					Rv1349		Rv1349			
NC_002945.3	Mycobrowser_v4	CDS	1515526	1516269	.	+	0	Mb1385	fabG2		probable 3-oxoacyl-[acyl-carrier protein] reductase fabg2 (3-ketoacyl-acyl carrier protein reductase)	Mb1385, fabG2, len: 247 aa. Equivalent to Rv1350,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 247 aa overlap). Probable fabG2,3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100),highly similar to many e.g. NP_350157.1|NC_003030 3-ketoacyl-acyl carrier protein reductase from Clostridium acetobutylicum (249 aa); NP_229523.1|NC_000853 3-oxoacyl-(acyl carrier protein) reductase from Thermotoga maritima (246 aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	X2BHF2,P66782,P66782	No				P66782					X2BHF2,P66782										
NC_002945.3	Mycobrowser_v4	CDS	1519920	1522067	.	-	0	Mb1390c	moeY		POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY	Mb1390c, moeY, len: 715 aa. Equivalent to Rv1355c,len: 715 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 715 aa overlap). Possible moeY,Molybdopterin biosynthesis protein, very weak similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis moeb protein (249 aa), FASTA scores, opt: 180, E(): 8.5e-05,(29.3% identity in 174 aa overlap).	Q7U074,A0A1R3Y090	No				A0A1R3Y090				IPR000415,IPR000594,IPR009036,IPR016040	Q7U074										
NC_002945.3	Mycobrowser_v4	CDS	1530478	1531668	.	-	0	Mb1396c	PPE19		ppe family protein ppe19	Mb1396c, PPE19, len: 396 aa. Similar to Rv1361c,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(92.9% identity in 396 aa overlap). PPE19 (alternate gene name: mtb39b). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to many e.g. Rv1196|MTCI364.08|PPE18, FASTA scores: E(): 0,(84.9% identity in 397 aa overlap); MTCY274.23c (42.3% identity in 416 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site. Note that expression of Rv1361c was demonstrated in lysates by immunodetection (see first citation below). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the PPE19 gene contains nine substitutions compared to Mycobacterium tuberculosis strain H37Rv.	Q7U071,A0A1R3XY45	No				A0A1R3XY45				IPR000030,IPR022171	Q7U071										
NC_002945.3	Mycobrowser_v4	CDS	1535818	1536204	.	-	0	Mb1400c	rsfa		anti-anti-sigma factor rsfa (anti-sigma factor antagonist) (regulator of sigma f a)	Mb1400c, -, len: 128 aa. Equivalent to Rv1365c,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 128 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08 (148 aa), FASTA scores: E(): 0, (53.6% identity in 125 aa overlap); Rv1904,Rv3687c. Weak similarity to putative anti-anti-sigma factors e.g. AF134889|AF134889_1 Streptomyces coelicolor (113 aa), FASTA scores: opt: 137, E(): 0.004, (26.0% identity in 100 aa overlap).	Q7U067,A0A1R3Y099	No	information pathways			A0A1R3Y099				IPR002645,IPR003658	Q7U067					Rv1365c		Rv1365c			
NC_002945.3	Mycobrowser_v4	CDS	1539055	1539840	.	+	0	Mb1403	lprF		probable conserved lipoprotein lprf	Mb1403, lprF, len: 261 aa. Equivalent to Rv1368,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Probable lipoprotein lprF, similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|Y08C_MYCTU|Q11049 hypothetical 26.4 kd protein cy50.12. (257 aa), FASTA scores: opt: 286,E(): 5.3e-11, (26.3% identity in 270 aa overlap), also Rv1411c|MTCY21B4.28c, (32.8% identity in 253 aa overlap) and Rv2945c. Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). BELONGS TO THE LPPX/LPRAFG FAMILY OF LIPOPROTEINS.	X2BHQ5,P65315,P65315	No	cell wall and cell processes			P65315					X2BHQ5,P65315					Rv1368		Rv1368			
NC_002945.3	Mycobrowser_v4	CDS	1561080	1561706	.	+	0	Mb1424	gmk		PROBABLE GUANYLATE KINASE GMK	Mb1424, gmk, len: 208 aa. Equivalent to Rv1389,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 208 aa overlap). Probable gmk, guanylate kinase (EC 2.7.4.8), similar to e.g. KGUA_ECOLI|P24234 guanylate kinase from Escherichia coli (207 aa), FASTA scores: opt: 424, E(): 6.6e-20, (35.9% identity in 184 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00856 Guanylate kinase signature. BELONGS TO THE GUANYLATE KINASE FAMILY.	X2BHH9,P0A5I5,P0A5I5	No	intermediary metabolism and respiration			P0A5I5					X2BHH9,P0A5I5					Rv1389		Rv1389			
NC_002945.3	Mycobrowser_v4	CDS	1571157	1572116	.	-	0	Mb1434c	nlhh		probable non lipolytic carboxylesterase nlhh	Mb1434c, lipH, len: 319 aa. Equivalent to Rv1399c,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 319 aa overlap). Possible LipH, lipase (EC 3.1.-.-), most similar to G695278 lipase like enzyme from Ralstonia eutropha (364 aa), FASTA scores: opt: 648,E(): 4.4e-34, (37.3% identity in 327 aa ov erlap), similar to Mycobacterium tuberculosis hypothetical lipases e.g. Rv2284, Rv2485c, Rv1426c, etc.	Q7U047,A0A1R3XY93	No				A0A1R3XY93				IPR013094	Q7U047										
NC_002945.3	Mycobrowser_v4	CDS	1549911	1550870	.	+	0	Mb1415	pyrB		PROBABLE ASPARTATE CARBAMOYLTRANSFERASE PYRB (ATCase) (Aspartate transcarbamylase)	Mb1415, pyrB, len: 319 aa. Equivalent to Rv1380,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 319 aa overlap). Probable pyrB,aspartate carbamoyltransferase (EC 2.1.3.2), similar to many e.g. PYRB_BACCL|P41008 aspartate carbamoyltransferase from Bacillus caldolyticus (308 aa), FASTA scores, opt: 639, E(): 7.3e-36, (39.5% identity in 311 aa overlap). Contains PS00097 Aspartate and ornithine carbamoyltransferases signature. BELONGS TO THE ATCASES/OTCASES FAMILY.	X2BHX3,P65614,P65614	No	intermediary metabolism and respiration			P65614					X2BHX3,P65614					Rv1380		Rv1380			
NC_002945.3	Mycobrowser_v4	CDS	1550867	1552159	.	+	0	Mb1416	pyrC		PROBABLE DIHYDROOROTASE PYRC (DHOase)	Mb1416, pyrC, len: 430 aa. Equivalent to Rv1381,len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 430 aa overlap). Probable pyrC,dihydroorotase (EC 3.5.2.3), similar to many e.g. PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap). Contains PS00483 Dihydroorotase signature 2. BELONGS TO THE DHOASE FAMILY. SUBFAMILY 2.	X2BHQ7,Q7U057,Q7U057	No	intermediary metabolism and respiration			Q7U057					X2BHQ7,Q7U057					Rv1381		Rv1381			
NC_002945.3	Mycobrowser_v4	CDS	1552650	1553780	.	+	0	Mb1418	carA		PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN CARA (Carbamoyl-phosphate synthetase glutamine chain)	Mb1418, carA, len: 376 aa. Equivalent to Rv1383,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 376 aa overlap). Probable carA,Carbamoyl-phosphate synthase small chain (EC 6.3.5.5),similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate synthase small chain from Escherichia coli (382 aa), FASTA scores: opt: 796, E(): 0, (45.5% identity in 382 aa overlap). Contains PS00442 Glutamine amidotransferases class-I active site. THE GATASE DOMAIN BELONGS TO TYPE-1 GLUTAMINE AMIDOTRANSFERASES. SUBUNIT: COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE.	X2BHS1,Q7U055,Q7U055	No	intermediary metabolism and respiration			Q7U055					X2BHS1,Q7U055					Rv1383		Rv1383			
NC_002945.3	Mycobrowser_v4	CDS	1568806	1570164	.	-	0	Mb1431c	PE_PGRS25		pe-pgrs family protein pe_pgrs25	Mb1431c, PE_PGRS25, len: 452 aa. Similar to Rv1396c, len: 576 aa, from Mycobacterium tuberculosis strain H37Rv, (78.1% identity in 576 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, strong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa),FASTA scores: opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A,similar to other PGRS-type sequences. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa).	Q7U049,A0A1R3XZ81	No				A0A1R3XZ81				IPR000084	Q7U049										
NC_002945.3	Mycobrowser_v4	CDS	1553780	1557127	.	+	0	Mb1419	carB		PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN CARB (Carbamoyl-phosphate synthetase ammonia chain)	Mb1419, carB, len: 1115 aa. Equivalent to Rv1384,len: 1115 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1115 aa overlap). Probable carB,Carbamoyl-phosphate synthase large chain (EC 6.3.5.5),similar to many e.g. CARB_ECOLI|P00968 E. coli (1072 aa),FASTA scores: E(): 0, (52.3% identity in 1118 aa overlap). Contains two PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00866 Carbamoyl-phosphatesynthase subdomain signature 1. SUBUNIT: COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA,WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE.	X2BHH6,Q7U054,Q7U054	No				Q7U054					X2BHH6,Q7U054										
NC_002945.3	Mycobrowser_v4	CDS	1557124	1557948	.	+	0	Mb1420	pyrF		PROBABLE OROTIDINE 5'-PHOSPHATE DECARBOXYLASE PYRF (OMP decarboxylase) (OMPdecase)	Mb1420, pyrF, len: 274 aa. Equivalent to Rv1385,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 274 aa overlap). Probable pyrF,orotidine 5'-phosphate decarboxylase (EC 4.1.1.23),identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. BELONGS TO THE OMP DECARBOXYLASE FAMILY.	X2BHX9,P0A5M7,P0A5M7	No	intermediary metabolism and respiration			P0A5M7					X2BHX9,P0A5M7					Rv1385		Rv1385			
NC_002945.3	Mycobrowser_v4	CDS	1558143	1558451	.	+	0	Mb1421	PE15		pe family protein pe15	Mb1421, PE15, len: 102 aa. Equivalent to Rv1386,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 102 aa overlap). Member of Mycobacterium tuberculosis PE family (see first citation below), similar to many e.g. G913039 ORF 3' OF PGRS TANDEM REPEAT (polymorphic GC-rich sequence) (100 aa), FASTA scores: opt: 149, E(): 0.0013, (31.5% identity in 92 aa overlap); also similar to Q49943|U1756A (99 aa) (34.7% identity in 95 aa overlap) and G466937|U1620K (100 aa) (36.2% identity in 69 aa overlap).	X2BHR2,P0A683	No	PE/PPE			P0A683					X2BHR2					Rv1386		Rv1386			
NC_002945.3	Mycobrowser_v4	CDS	1558448	1560067	.	+	0	Mb1422	PPE20		ppe family protein ppe20	Mb1422, PPE20, len: 539 aa. Equivalent to Rv1387,len: 539 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 539 aa overlap). Member of Mycobacterium tuberculosis PPE family of proteins, similar to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein cy251.15 (463 aa), FASTA scores: E(): 4.2e-26,(37.7% identity in 531 aa overlap); similar also to MTCY274.23c (37.5% identity in 168 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.	Q7U053,A0A1R3XY78	No				A0A1R3XY78				IPR000030	Q7U053										
NC_002945.3	Mycobrowser_v4	CDS	1562120	1563376	.	+	0	Mb1426	dfp		PROBABLE DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN HOMOLOG DFP	Mb1426, dfp, len: 418 aa. Equivalent to Rv1391,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 418 aa overlap). Probable dfp,DNA/pantothenate metabolism flavoprotein homolog, similar to many e.g. DFP_ECOLI|P24285 Escherichia coli (430 aa),FASTA scores: opt: 763, E(): 0, (40.2% identity in 408 aa overlap).	X2BHR8,P67734,P67734	No	intermediary metabolism and respiration			P67734					X2BHR8,P67734					Rv1391		Rv1391			
NC_002945.3	Mycobrowser_v4	CDS	1563504	1564715	.	+	0	Mb1427	metK		PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE METK (MAT) (AdoMet synthetase) (Methionine adenosyltransferase)	Mb1427, metK, len: 403 aa. Equivalent to Rv1392,len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 403 aa overlap). Probable metK,S-adenosylmethionine synthetase (EC 2.5.1.6), similar to many e.g. METK_STAAU|P50307 Staphylococcus aureus (397 aa), FASTA scores: opt: 1484, E(): 0, (58.0% identity in 400 aa overlap). Contains PS00376 S-adenosylmethionine synthetase signature 1, PS00377 S-adenosylmethionine synthetase signature 2. BELONGS TO THE ADOMET SYNTHETASE FAMILY.	X2BI76,Q7U051,Q7U051	No	intermediary metabolism and respiration			Q7U051					X2BI76,Q7U051					Rv1392		Rv1392			
NC_002945.3	Mycobrowser_v4	CDS	1566263	1567648	.	-	0	Mb1429c	cyp132		PROBABLE CYTOCHROME P450 132 CYP132	Mb1429c, cyp132, len: 461 aa. Equivalent to Rv1394c, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 461 aa overlap). Probable cyp132, cytochrome P450 132 (EC 1.14.-.- ). Some similarity to others e.g. CP4B_HUMAN|P13584 human cytochrome p450 (511 aa), FASTA scores: opt: 486, E(): 7.4e-21, (28.6% identity in 423 aa overlap); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. MAY BELONG TO THE CYTOCHROME P450 FAMILY.	X2BHI2,P59954,P59954	No	intermediary metabolism and respiration			P59954					X2BHI2,P59954					Rv1394c		Rv1394c			
NC_002945.3	Mycobrowser_v4	CDS	1572141	1573103	.	-	0	Mb1435c	lipI		PROBABLE LIPASE LIPH	Mb1435c, lipI, len: 320 aa. Equivalent to Rv1400c,len: 320 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 320 aa overlap). Possible lipI, lipase (EC 3.1.-.-), most similar to G695278 lipase like enzyme (364 aa), FASTA sscores: opt: 611, E(): 3.5e-30, (36.6% identity in 352 aa overlap); similar to Mycobacterium tuberculosis hypothetical lipases e.g. Rv1399c|MTCY21B4.16c (58.1% identical in 315 aa overlap); Rv1426c, Rv2284, etc.	Q7U046,A0A1R3XY96	No				A0A1R3XY96				IPR002168,IPR013094	Q7U046										
NC_002945.3	Mycobrowser_v4	CDS	1932370	1932759	.	-	0	Mb1749c	vapc12		possible toxin vapc12	Mb1749c, -, len: 129 aa. Equivalent to Rv1720c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53610|Rv0065|MTV030.08 (133 aa), FASTA scores: E(): 1.5e-10, (39.1% identity in 128 aa overlap); P71550|Rv0960|MTCY10D7.14C (129 aa) and O06415|Rv0549c|MTCY25D10.28C (137 aa).	Q7TZQ4,A0A1R3XZ41	No	virulence, detoxification, adaptation			A0A1R3XZ41				IPR002716,IPR022907	Q7TZQ4					Rv1720c		Rv1720c			
NC_002945.3	Mycobrowser_v4	CDS	1573920	1575887	.	+	0	Mb1437	priA		PUTATIVE PRIMOSOMAL PROTEIN N' PRIA (Replication factor Y)	Mb1437, priA, len: 655 aa. Equivalent to Rv1402,len: 655 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 655 aa overlap). Putative priA,primosomal protein N'. Similar to e.g. PRIA_ECOLI|P17888 primosomal protein N' (replication factor Y) (732 aa),FASTA scores, opt: 386, E(): 1.3e-16, (27.6% identity in 711 aa overlap). Compared to other bacterial priA, it has a very divergent helicase domain. BELONGS TO THE HELICASE FAMILY. PRIA SUBFAMILY.	X2BI84,P0A5A6,P0A5A6	No	information pathways			P0A5A6					X2BI84,P0A5A6					Rv1402		Rv1402			
NC_002945.3	Mycobrowser_v4	CDS	1578473	1579411	.	+	0	Mb1441	fmt		PROBABLE METHIONYL-TRNA FORMYLTRANSFERASE FMT	Mb1441, fmt, len: 312 aa. Equivalent to Rv1406,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 312 aa overlap). Probable fmt,methionyl-tRNA formyltransferase (EC 2.1.2.9), similar to many e.g. FMT_ECOLI|P23882 Escherichia coli (314 aa),FASTA scores: opt: 616, E(): 6.7e-31, (39.3% identity in 303 aa overlap). BELONGS TO THE FMT FAMILY.	X2BHT2,P64135,P64135	No	information pathways			P64135					X2BHT2,P64135					Rv1406		Rv1406			
NC_002945.3	Mycobrowser_v4	CDS	1579408	1580781	.	+	0	Mb1442	fmu		PROBABLE FMU PROTEIN (SUN PROTEIN)	Mb1442, fmu, len: 457 aa. Equivalent to Rv1407,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 457 aa overlap). Probable fmu protein,similar to SUN_ECOLI|P36929 sun protein (fmu protein) from Escherichia coli (429 aa), FASTA scores: E(): 2.5e-20,(30.6% identity in 451 aa overlap).	Q7U044,A0A1R3XY95	No	information pathways			A0A1R3XY95				IPR001678,IPR006027,IPR018314,IPR023267	Q7U044					Rv1407		Rv1407			
NC_002945.3	Mycobrowser_v4	CDS	1580806	1581504	.	+	0	Mb1443	rpe		PROBABLE RIBULOSE-PHOSPHATE 3-EPIMERASE RPE (PPE) (R5P3E) (Pentose-5-phosphate 3-epimerase)	Mb1443, rpe, len: 232 aa. Equivalent to Rv1408,len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 232 aa overlap). Probable rpe,ribulose-phosphate 3-epimerase (EC 5.1.3.1), similar to many e.g. CXEC_ALCEU|P40117 (241 aa), FASTA scores: opt: 638, E(): 1.5e-34, (48.3% identity in 234 aa overlap); and RPE_ECOLI|P32661 ribulose-phosphate 3-epimerase (225 aa),FASTA scores: E(): 0, (46.2% identity in 221 aa overlap). Contains PS01085 Ribulose-phosphate 3-epimerase family signature 1. BELONGS TO THE RIBULOSE-PHOSPHATE 3-EPIMERASE FAMILY.	X2BHU6,P65761,P65761	No	intermediary metabolism and respiration			P65761					X2BHU6,P65761					Rv1408		Rv1408			
NC_002945.3	Mycobrowser_v4	CDS	1581501	1582520	.	+	0	Mb1444	ribG		PROBABLE BIFUNCTIONAL riboflavin biosynthesis protein RIBG : Diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase)	Mb1444, ribG, len: 339 aa. Equivalent to Rv1409,len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 339 aa overlap). Probable ribG (alternate gene name: ribD), bifunctional riboflavin biosynthesis protein, including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), similar to many e.g. RIBD_ECOLI|P25539 riboflavin-specific deaminase from Escherichia coli (367 aa), FASTA scores: E(): 0, (39.8% identity in 364 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. IN THE N-TERMINAL SECTION; BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HTP REDUCTASE FAMILY.	Q7U043,A0A1R3XYA3	No	intermediary metabolism and respiration			A0A1R3XYA3				IPR002125,IPR002734,IPR004794,IPR016192,IPR016193,IPR024072	Q7U043					Rv1409		Rv1409			
NC_002945.3	Mycobrowser_v4	CDS	1584079	1584789	.	-	0	Mb1446c	lprG		conserved lipoprotein lprg	Mb1446c, lprG, len: 236 aa. Equivalent to Rv1411c,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 236 aa overlap). Probable lprG (alternate gene name: P27), conserved lipoprotein, similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|MTCY50.12 (35.1% identity in 245 aa overlap); Rv1368, Rv2945c. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in M. bovis BCG (see second citation).	X2BHT9,P0A5I9,P0A5I9	No				P0A5I9					X2BHT9,P0A5I9										
NC_002945.3	Mycobrowser_v4	CDS	1584874	1585479	.	+	0	Mb1447	ribC		PROBABLE RIBOFLAVIN SYNTHASE ALPHA CHAIN RIBC (RIBE)	Mb1447, ribC, len: 201 aa. Equivalent to Rv1412,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 201 aa overlap). Probable ribC (ribE),Riboflavin synthase alpha chain (EC 2.5.1.9), strong similarity to others e.g. RISA_ACTPL|P50854 (215 aa),FASTA scores: opt: 586, E(): 1.8e-33, (50.8% identity in 197 aa overlap). Contains 2 x PS00693 Riboflavin synthase alpha chain family signature.	X2BI92,P65328,P65328	No	intermediary metabolism and respiration			P65328					X2BI92,P65328					Rv1412		Rv1412			
NC_002945.3	Mycobrowser_v4	CDS	1932756	1932983	.	-	0	Mb1750c	vapb12		possible antitoxin vapb12	Mb1750c, -, len: 75 aa. Equivalent to Rv1721c, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 75 aa overlap). Conserved hypothetical protein, similar to Rv0300|MTCY63.05|O07227 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (73 aa). Start changed since original submission.	Q7TZQ3,A0A1R3Y196	No	virulence, detoxification, adaptation			A0A1R3Y196				IPR010985	Q7TZQ3					Rv1721c		Rv1721c			
NC_002945.3	Mycobrowser_v4	CDS	1586704	1587981	.	+	0	Mb1450	ribA2		PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)	Mb1450, ribA2, len: 425 aa. Equivalent to Rv1415,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 425 aa overlap). Probable ribA2,Riboflavin biosynthesis protein (EC 3.5.4.25), similar to many e.g. GCH2_BACSU|P17620 from Bacillus subtilis (398 aa), FASTA scores: opt: 1388, E(): 0, (55.4% identity in 399 aa overlap). Also similar to second Mycobacterium tuberculosis gtp cyclohydrolase Rv1940|ribA1 (353 aa). IN THE N-TERMINAL SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II FAMILY.	X2BI18,P0A5V1,P0A5V1	No				P0A5V1					X2BI18,P0A5V1										
NC_002945.3	Mycobrowser_v4	CDS	1587996	1588460	.	+	0	Mb1451	ribH		PROBABLE RIBOFLAVIN SYNTHASE BETA CHAIN RIBH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (Lumazine synthase)	Mb1451, ribH, len: 154 aa. Equivalent to Rv1416,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Probable ribH,riboflavin synthase beta chain (EC 2.5.1.9), similar to many e.g. RISB_ECOLI|P25540 Escherichia coli (156 aa),FASTA scores: opt: 330, E(): 1.8e-15, (44.1% identity in 145 aa overlap). Note alternative GTG start possible overlapping the stop codon of Rv1415|MTCY21B4.33. BELONGS TO THE DMRL SYNTHASE FAMILY.	X2BHU4,P66035,P66035	No	intermediary metabolism and respiration			P66035					X2BHU4,P66035					Rv1416		Rv1416			
NC_002945.3	Mycobrowser_v4	CDS	1588946	1589632	.	+	0	Mb1453	lprH		PROBABLE LIPOPROTEIN LPRH	Mb1453, lprH, len: 228 aa. Equivalent to Rv1418,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 228 aa overlap). Probable lprH,lipoprotein. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).	X2BHV9,P65317,P65317	No	cell wall and cell processes			P65317					X2BHV9,P65317					Rv1418		Rv1418			
NC_002945.3	Mycobrowser_v4	CDS	1590349	1592289	.	+	0	Mb1455	uvrC		probable excinuclease abc (subunit c-nuclease) uvrc	Mb1455, uvrC, len: 646 aa. Equivalent to Rv1420,len: 646 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 646 aa overlap). Probable uvrC,excinuclease ABC subunit C, similar to many e.g. UVRC_PSEFL|P32966 Pseudomonas fluorescens (607 aa), fasta scores: opt: 738, E(): 8.4e-39, (36.6% identity in 629 aa overlap). BELONGS TO THE UVRC FAMILY.	X2BI25,P67427,P67427	No	information pathways			P67427					X2BI25,P67427					Rv1420		Rv1420			
NC_002945.3	Mycobrowser_v4	CDS	1594213	1595190	.	+	0	Mb1458	whiA		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIA	Mb1458, whiA, len: 325 aa. Equivalent to Rv1423,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 325 aa overlap). Putative whiA,transcriptional regulator, probably equivalent to AL035591|SCC54.10 whiA protein from Streptomyces coelicolor (328 aa), FASTA scores: opt: 1505, E(): 0,(70.4% identity in 324 aa overlap). Also some similarity to O06975|YVCL hypothetical protein from Bacillus subtilis (316 aa), FASTA scores: E(): 1.8e-0 8, (25.7% identity in 304 aa overlap).	X2BHW9,Q7U040,Q7U040	No	regulatory proteins			Q7U040					X2BHW9,Q7U040					Rv1423		Rv1423			
NC_002945.3	Mycobrowser_v4	CDS	1597366	1598628	.	-	0	Mb1461c	lipO		PROBABLE ESTERASE LIPO	Mb1461c, lipO, len: 420 aa. Equivalent to Rv1426c,len: 420 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 420 aa overlap). Possible Lipo, esterase (EC 3.1.-.-), similar to several Mycobacterium tuberculosis hypothetical lipases and esterases e.g. Rv1399c, Rv2284, etc. Also similar in central region to AAAD_HUMAN|P22760 human arylacetamide deacetylase (398 aa), FASTA scores: opt:210, E(): 7.6e-07, (29.3% identity in 191 aa overlap).	Q7U038,A0A1R3XZA8	No				A0A1R3XZA8				IPR013094	Q7U038										
NC_002945.3	Mycobrowser_v4	CDS	1598628	1600235	.	-	0	Mb1462c	fadD12		POSSIBLE LONG-CHAIN-FATTY-ACID--COA LIGASE FADD12 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb1462c, fadD12, len: 535 aa. Equivalent to Rv1427c, len: 535 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 535 aa overlap). Possible fadD12, long-chain-fatty-acid-CoA synthetase (EC 6.2.1.-),similar to many e.g. NP_302632.1|NC_002677 acyl-CoA synthase from Mycobacterium leprae (548 aa); AAD01929.2|AF031419 putative long-chain-fatty-acid--CoA ligase from Pseudomonas putida (565 aa); NP_419782.1|NC_002696 putative long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (530 aa); PC60_YEAST|P38137 yeast peroxisomal-coenzyme A synthetase (543 aa), FASTA scores: opt: 507, E(): 2.9e-25, (30.4% identity in 365 aa overlap). Also similar to many M. tuberculosis proteins e.g. MTCY06A4.14 (44.8% identity in 525 aa overlap). Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7U037,A0A1R3XYB5	No	lipid metabolism			A0A1R3XYB5				IPR000873,IPR020845,IPR025110	Q7U037					Rv1427c		Rv1427c			
NC_002945.3	Mycobrowser_v4	CDS	1602693	1604279	.	+	0	Mb1465	PE16		pe family protein pe16	Mb1465, PE16, len: 528 aa. Equivalent to Rv1430,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 528 aa overlap). Member of the M. tuberculosis PE family of proteins e.g. Y0D4_MYCTU|Q50594 (55.9% identity in 127 aa overlap). The C-terminus shows similarity to Q49633|LEPB1170_F3_112 hypothetical Mycobacterium leprae protein (391 aa), FASTA scores: opt: 342, E(): 1.2e-13, (29.8% identity in 292 aa overlap). Possible TMhelix aa 500-522.	Q7U034,A0A1R3XYC9	No	PE/PPE			A0A1R3XYC9				IPR000084,IPR013228	Q7U034					Rv1430		Rv1430			
NC_002945.3	Mycobrowser_v4	CDS	1655726	1656100	.	+	0	Mb1505	trxA		PROBABLE THIOREDOXIN TRXA	Mb1505, trxA, len: 124 aa. Equivalent to Rv1470,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Probable trxA,thioredoxin (EC 1.-.-.-), similar to many e.g. P12243|THI1_SYNP7 THIOREDOXIN 1 from Synechococcus sp. (106 aa), FASTA scores: opt: 201, E(): 9.2e-08, (35.4% identity in 99 aa overlap); etc. Highly similar to downstream ORF Rv1471|trxB1 probable thioredoxin from M. tuberculosis (123 aa), FASTA scores: opt: 402, E(): 0,(54.4% identity in 114 aa overlap). Warning: note that Rv3914|MT4033|MTV028.05|trxC can be alternatively named trxA.	Q7U006,A0A1R3XYG2	No	intermediary metabolism and respiration			A0A1R3XYG2				IPR005746,IPR012336,IPR013766	Q7U006					Rv1470		Rv1470			
NC_002945.3	Mycobrowser_v4	CDS	1609635	1610654	.	+	0	Mb1471	gap		PROBABLE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GAP (GAPDH)	Mb1471, gap, len: 339 aa. Equivalent to Rv1436,len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 339 aa overlap). Probable gap,Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12),highly similar to many e.g. G3P_MYCLE|P46713 Mycobacterium leprae (339 aa), FASTA scores: opt: 1933, E():0, (89.1% identity in 339 aa overlap). Contains PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. BELONGS TO THE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FAMILY.	X2BHX4,P64179,P64179	No	intermediary metabolism and respiration			P64179					X2BHX4,P64179					Rv1436		Rv1436			
NC_002945.3	Mycobrowser_v4	CDS	1610657	1611895	.	+	0	Mb1472	pgk		PROBABLE PHOSPHOGLYCERATE KINASE PGK	Mb1472, pgk, len: 412 aa. Equivalent to Rv1437,len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 412 aa overlap). Probable pgk,Phosphoglycerate kinase (EC 2.7.2.3), highly similar to many e.g. PGK_MYCLE|P46712 Mycobacterium leprae (416 aa),FASTA scores: opt: 2153, E(): 0, (80.4% identity in 414 aa overlap). Contains PS00111 Phosphoglycerate kinase signature. BELONGS TO THE PHOSPHOGLYCERATE KINASE FAMILY.	X2BIC0,P65701,P65701	No	intermediary metabolism and respiration			P65701					X2BIC0,P65701					Rv1437		Rv1437			
NC_002945.3	Mycobrowser_v4	CDS	1611892	1612677	.	+	0	Mb1473	tpi		PROBABLE TRIOSEPHOSPHATE ISOMERASE TPI (TIM)	Mb1473, tpi, len: 261 aa. Equivalent to Rv1438,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Probable tpi (tpiA),Triosephosphate isomerase (EC 5.3.1.1), highly similar to many e.g. TPIS_MYCLE|P46711 Mycobacterium leprae (261 aa),FASTA scores: opt: 1456, E(): 0, (83.9% identity in 261 aa overlap). Contains PS00171 Triosephosphate isomerase active site. BELONGS TO THE TRIOSEPHOSPHATE ISOMERASE FAMILY.	X2BHY6,P66941,P66941	No	intermediary metabolism and respiration			P66941					X2BHY6,P66941					Rv1438		Rv1438			
NC_002945.3	Mycobrowser_v4	CDS	1614537	1616012	.	-	0	Mb1476c	PE_PGRS26		pe-pgrs family protein pe_pgrs26	Mb1476c, PE_PGRS26, len: 491 aa. Equivalent to Rv1441c, len: 491 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 491 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kd protein (498 aa), fasta scores: opt: 1625, E(): 0, (55.2% identity in 518 aa overlap).	Q7U027,A0A1R3XYC1	No				A0A1R3XYC1				IPR000084	Q7U027										
NC_002945.3	Mycobrowser_v4	CDS	1616119	1618419	.	+	0	Mb1477	bisC		PROBABLE BIOTIN SULFOXIDE REDUCTASE BISC (BDS reductase) (BSO reductase)	Mb1477, bisC, len: 766 aa. Equivalent to Rv1442,len: 766 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 766 aa overlap). Probable bisC, Biotin sulfoxide reductase (EC 1.-.-.-), similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa), FASTA scores: opt: 1271, E():0,(40.2% identity in 744 aa overlap).	Q7U026,A0A1R3XYD3	No	intermediary metabolism and respiration			A0A1R3XYD3				IPR006656,IPR006657,IPR006658,IPR009010	Q7U026					Rv1442		Rv1442			
NC_002945.3	Mycobrowser_v4	CDS	1620061	1620804	.	-	0	Mb1480c	devB		PROBABLE 6-PHOSPHOGLUCONOLACTONASE DEVB (6PGL)	Mb1480c, devB, len: 247 aa. Equivalent to Rv1445c,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 247 aa overlap). Possible devB (PGL),6-phosphogluconolactonase (EC 3.1.1.31), belongs to a different family to the upstream gene zwf2. Similar to e.g. DEVB_ANASP|P46016 putative glucose-6-phosphate 1-dehydrogenase (239 aa), FASTA scores: opt: 439, E(): 2.6e-20, (34.0% identity in 247 aa overlap). BELONGS TO THE GLUCOSAMINE/GALACTOSAMINE-6-PHOSPHATE ISOMERASE FAMILY. 6-PHOSPHOGLUCONOLACTONASE SUBFAMILY.	X2BI57,P63339,P63339	No				P63339					X2BI57,P63339										
NC_002945.3	Mycobrowser_v4	CDS	1620801	1621712	.	-	0	Mb1481c	opcA		PUTATIVE OXPP CYCLE PROTEIN OPCA	Mb1481c, opcA, len: 303 aa. Equivalent to Rv1446c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 303 aa overlap). Putative opcA, OxPP cycle protein. Highly similar to S72774 B1496_F1_30 protein from Mycobacterium leprae (265 aa), FASTA scores: opt: 1056, E(): 0, (70.3% identity in 239 aa overlap). Also similar to OPCA_NOSS2|P48971 putative oxppcycle protein opca from Nostoc punctiforme (465 aa), fasta scores: opt: 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). AIDS IN G6PD ACTIVITY.	Q7U023,A0A1R3XZC7	No				A0A1R3XZC7				IPR004555	Q7U023										
NC_002945.3	Mycobrowser_v4	CDS	1621765	1623309	.	-	0	Mb1482c	zwf2		PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD)	Mb1482c, zwf2, len: 514 aa. Equivalent to Rv1447c,len: 514 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 514 aa overlap). Probable zwf2 (ZWF),Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), highly similar to many e.g. G6PD_SYNY3|P73411 Synechocystis sp. (509 aa), FASTA scores: opt: 1578, E(): 0, (46.8% identity in 509 aa overlap). Also similar to Mycobacterium tuberculosis Rv1121, zwf glucose-6-phosphate 1-dehydrogenase. Contains PS00069 Glucose-6-phosphate dehydrogenase active site. M. tuberculosis has two genes for ZWF. This one looks like a classical ZWF. BELONGS TO THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY.	X2BID3,P0A585,P0A585	No				P0A585					X2BID3,P0A585										
NC_002945.3	Mycobrowser_v4	CDS	1623306	1624427	.	-	0	Mb1483c	tal		PROBABLE TRANSALDOLASE TAL	Mb1483c, tal, len: 373 aa. Equivalent to Rv1448c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 373 aa overlap). Probable tal,Transaldolase (EC 2.2.1.2), highly similar to many e.g. TAL_MYCLE|P55193 transaldolase from Mycobacterium leprae (375 aa), FASTA scores: opt: 1891, E(): 0, (78.6% identity in 370 aa overlap). BELONGS TO THE TRANSALDOLASE FAMILY.	X2BI00,P59955,P59955	No				P59955					X2BI00,P59955										
NC_002945.3	Mycobrowser_v4	CDS	1624444	1626546	.	-	0	Mb1484c	tkt		transketolase tkt (tk)	Mb1484c, tkt, len: 700 aa. Equivalent to Rv1449c,len: 700 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 700 aa overlap). Probable tkt,Transketolase (EC 2.2.1.1). Highly similar to several e.g. TKT_MYCLE|P46708 transketolase (tk) from Mycobacterium leprae (699 aa), FASTA scores: opt: 4216, E(): 0, (89.1% identity in 700 aa overlap). Start site chosen by homology. Contains PS00801 Transketolase signature 1. BELONGS TO THE TRANSKETOLASE FAMILY.	X2BHN3,P59956,P59956	No				P59956					X2BHN3,P59956										
NC_002945.3	Mycobrowser_v4	CDS	1626985	1631211	.	-	0	Mb1485c	PE_PGRS27		pe-pgrs family protein pe_pgrs27	Mb1485c, PE_PGRS27, len: 1408 aa. Similar to Rv1450c, len: 1329 aa, from Mycobacterium tuberculosis strain H37Rv, (92.1% identity in 1417 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), fasta scores: opt: 2112, E(): 0, (56.5% identity in 630 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 27 bp, 207 bp and 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa).	Q7U022,A0A1R3XYE8	No				A0A1R3XYE8				IPR000084	Q7U022										
NC_002945.3	Mycobrowser_v4	CDS	1631613	1632539	.	+	0	Mb1486	ctaB		PROBABLE CYTOCHROME C OXIDASE ASSEMBLY FACTOR CTAB	Mb1486, ctaB, len: 308 aa. Equivalent to Rv1451,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 308 aa overlap). Probable ctaB,cytochrome C oxidase assembly factor, and integral membrane protein. Highly similar to several Mycobacterium leprae proteins e.g. Q49685 CYOE cytochrome O ubiquinol oxidase assembly factor (300 aa), FASTA scores: opt: 1636,E(): 0, (82.7% identity in 307 aa overlap); NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa); NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa).	X2BI03,Q7U021,Q7U021	No	intermediary metabolism and respiration			Q7U021					X2BI03,Q7U021					Rv1451		Rv1451			
NC_002945.3	Mycobrowser_v4	CDS	1632588	1634975	.	-	0	Mb1487c	PE_PGRS28		pe-pgrs family protein pe_pgrs28	Mb1487c, PE_PGRS28, len: 795 aa. Highly similar to Rv1452c, len: 741 aa, from Mycobacterium tuberculosis strain H37Rv, (89.1% identity in 795 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), fasta scores: opt: 2090, E(): 0, (56.3% identity in 641 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,substitutions of 3 bp to 144 bp, 40 bp to 49 bp, 31 bp to 31 bp, 4 bp to 4 bp (gggc-ttgg), 12 bp to 12 bp, 11 bp to 11 bp, 60 bp to 63 bp, 13 bp to 13 bp and 2 bp to 2 bp (tt-cc), and a 9 bp insertion (*-cccgccggc), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (795 aa versus 741 aa).	Q7U020,A0A1R3XYE4	No				A0A1R3XYE4				IPR000084	Q7U020										
NC_002945.3	Mycobrowser_v4	CDS	1727791	1728384	.	-	0	Mb1568c	lprI		Possible lipoprotein lprI	Mb1568c, lprI, len: 197 aa. Equivalent to Rv1541c,len: 197 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 197 aa overlap). Possible lipoprotein lprI, contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS0013).	X2BI97,P65319,P65319	No				P65319					X2BI97,P65319										
NC_002945.3	Mycobrowser_v4	CDS	1636420	1637406	.	-	0	Mb1489c	qor		PROBABLE QUINONE REDUCTASE QOR (NADPH:quinone reductase) (Zeta-crystallin homolog protein)	Mb1489c, qor, len: 328 aa. Equivalent to Rv1454c,len: 328 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 328 aa overlap). Probable qor, quinone oxidoreductase (EC 1.6.5.5), simiar to U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter capsulatus (323 aa), FASTA scores: opt: 849, E(): 0, (44.7% identity in 329 aa overlap). Also similar to MTCY180.06 Hypothetical protein from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 430, E(): 2e-14, (32.3% identity in 350 aa overlap). Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature.	Q7U018,A0A1R3XYD6	No				A0A1R3XYD6				IPR002085,IPR011032,IPR013149,IPR013154,IPR016040	Q7U018										
NC_002945.3	Mycobrowser_v4	CDS	1648264	1649517	.	+	0	Mb1499	csd		PROBABLE CYSTEINE DESULFURASE CSD	Mb1499, csd, len: 417 aa. Equivalent to Rv1464,len: 417 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 417 aa overlap). Probable csd, cysteine desulfurase (EC 4.4.1.- ). Equivalent to Q49690|MLCL536.25C cysteine desulfurase from Mycobacterium leprae (418 aa), FASTA scores: opt: 2333, E(): 0, (85.4% identity in 417 aa overlap); and similar to cysteine desulfurase from other organisms. Also similar to M. tuberculosis proteins Rv3025c|ISCS and Rv3778c. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. CSD SUBFAMILY.	X2BHR0,P63517,P63517	No	intermediary metabolism and respiration			P63517					X2BHR0,P63517					Rv1464		Rv1464			
NC_002945.3	Mycobrowser_v4	CDS	1650419	1652248	.	-	0	Mb1502c	fadE15		PROBABLE ACYL-COA DEHYDROGENASE FADE15	Mb1502c, fadE15, len: 609 aa. Equivalent to Rv1467c, len: 609 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 609 aa overlap). Probable fadE15, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to NP_302639.1|NC_002677 acyl-CoA dehydrogenase from Mycobacterium leprae (611 aa). Also highly similar to many e.g. T36481 probable acyl-CoA dehydrogenase (fragment) from Streptomyces coelicolor (491 aa) (has its N-terminus very shorter); NP_384640.1|NC_003047 PUTATIVE ACYL-COA DEHYDROGENASE PROTEIN from Sinorhizobium meliloti (598 aa); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain specific) from Megasphaera elsdenii (383 aa),FASTA scores: E(): 2e-12, (25.4% identity in 410 aa overlap); etc. Also highly similar to fadE5|Rv0244c|MTV034.10c ACYL-COA DEHYDROGENASE from M. tuberculosis (611 aa); and similar to other proteins from Mycobacterium tuberculosis.	Q7U008,A0A1R3XYF3	No	lipid metabolism			A0A1R3XYF3				IPR006091,IPR009075,IPR009100,IPR013786,IPR020953,IPR025878	Q7U008					Rv1467c		Rv1467c			
NC_002945.3	Mycobrowser_v4	CDS	1652355	1653467	.	-	0	Mb1503c	PE_PGRS29		pe-pgrs family protein pe_pgrs29	Mb1503c, PE_PGRS29, len: 370 aa. Equivalent to Rv1468c, len: 370 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 370 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins.	Q7U007,A0A1R3XYU6	No				A0A1R3XYU6				IPR000084	Q7U007										
NC_002945.3	Mycobrowser_v4	CDS	1653709	1655682	.	+	0	Mb1504	ctpD		PROBABLE CATION TRANSPORTER P-TYPE ATPASE D CTPD	Mb1504, ctpD, len: 657 aa. Equivalent to Rv1469,len: 657 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 657 aa overlap). Probable ctpD,cation-transporting P-type ATPase D (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. T35947 probable cation-transporting ATPase from Streptomyces coelicolor (638 aa); NP_442633.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (642 aa), FASTA scores: opt: 1438, E(): 0, (41.9% identity in 592 aa overlap); NP_389268.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (637 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3743c|MTV025.091c|CTPJ (660 aa). Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.	X2BHR4,P63686,P63686	No	cell wall and cell processes			P63686					X2BHR4,P63686					Rv1469		Rv1469			
NC_002945.3	Mycobrowser_v4	CDS	1656116	1656487	.	+	0	Mb1506	trxB1		PROBABLE THIOREDOXIN TRXB1	Mb1506, trxB1, len: 123 aa. Equivalent to Rv1471,len: 123 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 123 aa overlap). Probable trxB1,thioredoxin (EC 1.-.-.-), similar to many bacterial thioredoxins e.g. P33636|THI2_ECOLI from Escherichia coli (139 aa), FASTA scores: opt: 290, E(): 1.8e-13, (44.3% identity in 97 aa overlap); etc. Highly similar to Rv1470|TrxA probable thioredoxin from Mycobacterium tuberculosis (124 aa), FASTA scores: opt: 402, E(): 1.2e-32, (54.4% identity in 114 aa overlap). Contains PS00194 Thioredoxin family active site. BELONGS TO THE THIOREDOXIN FAMILY. Note that previously known as trxB.	Q7U005,A0A1R3XYF1	No				A0A1R3XYF1				IPR005746,IPR012336,IPR013766,IPR017937	Q7U005										
NC_002945.3	Mycobrowser_v4	CDS	1656509	1657366	.	+	0	Mb1507	echA12		POSSIBLE ENOYL-CoA HYDRATASE ECHA12 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)	Mb1507, echA12, len: 285 aa. Equivalent to Rv1472,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Possible echA12,enoyl-CoA hydratase (EC 4.2.1.17), highly similar to P53526|ECHH_MYCLE|NP_301896.1|NC_002677 possible enoyl-CoA hydratase/isomerase from Mycobacterium leprae (294 aa),FASTA scores: opt: 1265, E(): 0, (72.0% identity in 271 aa overlap). Also similar to others e.g. CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli strain K12 (262 aa); CAC44593.1|AL596162 putative enoyl-CoA hydratase from Streptomyces coelicolor (275 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. ECHA16|Rv2831|MTCY16B7.11c (249 aa), FASTA scores: opt: 232, E(): 1.3e-15, (33.8% identity in 204 aa overlap); etc. TBparse score is 0.916.	X2BIH9,Q7U004,Q7U004	No				Q7U004					X2BIH9,Q7U004										
NC_002945.3	Mycobrowser_v4	CDS	1659961	1662792	.	-	0	Mb1511c	acn		probable iron-regulated aconitate hydratase acn (citrate hydro-lyase) (aconitase)	Mb1511c, acn, len: 943 aa. Equivalent to Rv1475c,len: 943 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 943 aa overlap). Probable acn, aconitate hydratase (EC 4.2.1.3), similar to many e.g. P70920|ACON_BRAJA ACONITATE HYDRATASE from Bradyrhizobium japonicum (906 aa), FASTA scores: opt:1912, E(): 0, (54.8% identity in 958 aa overlap); closest to AF0021|AF002133_2 Mycobacterium avium strain GIR10 (961 aa), FASTA scores: opt: 5072, E(): 0, (82.8% identity in 943 aa overlap). NOTE ACONITASE HAS AN ACTIVE (4FE-4S) AND AN INACTIVE (3FE-4S) FORMS. THE ACTIVE (4FE-4S) CLUSTER IS PART OF THE CATALYTIC SITE THAT INTERCONVERTS CITRATE, CIS-ACONITASE,AND ISOCITRATE.	Q7U000,A0A1R3XZG0	No				A0A1R3XZG0				IPR000573,IPR001030,IPR015928,IPR015931,IPR015932,IPR015934,IPR015937,IPR018136	Q7U000										
NC_002945.3	Mycobrowser_v4	CDS	1728439	1728849	.	-	0	Mb1569c	glbN		hemoglobin glbn	Mb1569c, glbN, len: 136 aa. Equivalent to Rv1542c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 136 aa overlap). Probable glbN,hemoglobin. Belongs to the protozoan/cyanobacterial globin family. Similar to myoglobins e.g. GLB_PARCA|P15160 myoglobin (hemoglobin) paramecium (116 aa), FASTA scores,opt: 284, E(): 2.1e -13, (35.7% identity in 115 aa overlap). Similar to Mycobacterium tuberculosis hypothetical globin, Rv2470.	X2BHW6,P0A593,P0A593	No				P0A593					X2BHW6,P0A593										
NC_002945.3	Mycobrowser_v4	CDS	1663736	1665154	.	+	0	Mb1513	ripa		peptidoglycan hydrolase	Mb1513, -, len: 472 aa. Equivalent to Rv1477, len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 472 aa overlap). Hypothetical Invasion protein. Possibly exported protein with unusually long signal sequence. The last 277 residues are nearly identical to those of AF0060|AF006054_1 hypothetical invasion protein INV1 from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 1833, E(): 0, (98.2% identity in 277 aa overlap); also very similar to AF0021|AF002133_4 invasin 1 protein from Mycobacterium avium (273 aa), FASTA scores: opt: 1452, E(): 0, (78.1% identity in 279 aa overlap). Similar to Rv1566c|MTCY336.37|Z95586 Mycobacterium tuberculosis cosmid (230 aa), FASTA scores: opt: 528, E(): 4.4e-20, (52.0% identity in 150 aa overlap); and weakly similar to p60 proteins of Listeria spp throughout its length e.g. M80351|LISIAPB_1 Listeria monocytogenes iap-related protein (478 aa), FASTA scores: opt: 251, E(): 8e-06, (24.4% identity in 487 aa overlap). C-terminal domain highly similar to next ORF Rv1478|MTV007.25.	Q7TZZ8,A0A1R3XYV5	No	virulence, detoxification, adaptation			A0A1R3XYV5				IPR000064	Q7TZZ8					Rv1477		Rv1477			
NC_002945.3	Mycobrowser_v4	CDS	1720532	1723657	.	+	0	Mb1563	ileS		isoleucyl-tRNA synthetase ileS	Mb1563, ileS, len: 1041 aa. Equivalent to Rv1536,len: 1041 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1041 aa overlap). ileS,Isoleucyl-tRNA synthetase (EC 6.1.1.5) , similar to several e.g. SYIC_YEAST P09436 isoleucyl-tRNA synthetase (1072 aa), FASTA scores: opt: 1447, E(): 0, (37.8% identity in 1072 aa overlap); contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BI93,Q7VEZ0,Q7VEZ0	No				Q7VEZ0					X2BI93,Q7VEZ0										
NC_002945.3	Mycobrowser_v4	CDS	1666029	1667162	.	+	0	Mb1515	moxR1		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN MOXR1	Mb1515, moxR1, len: 377 aa. Equivalent to Rv1479,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 377 aa overlap). Probable moxR1,transcriptional regulatory protein, similar to X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi (329 aa), FASTA scores: opt: 850, E():0,(43.5% identity in 317 aa overlap); and P. denitrificans. Highly similar to MoxR homologs of Mycobacterium tuberculosis and M. avium (but these both differ at C-terminus) e.g. Rv3692, Rv3164c, and AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309 aa), FASTA scores: opt: 1181, E(): 0, (83.7% identity in 227 aa overlap). Also similar to O33173|AF006054 MoxR fragment from Mycobacterium tuberculosis (211 aa), FASTA scores: opt: 1305, E(): 0, (94.3% identity in 212 aa overlap). Note that previously known as moxR.	Q7TZZ6,A0A1R3XYH3	No				A0A1R3XYH3				IPR003593,IPR011703,IPR016366,IPR027417	Q7TZZ6										
NC_002945.3	Mycobrowser_v4	CDS	1670186	1670929	.	+	0	Mb1519	fabG1		3-oxoacyl-[acyl-carrier protein] reductase fabg1 (3-ketoacyl-acyl carrier protein reductase) (mycolic acid biosynthesis a protein)	Mb1519, fabG1, len: 247 aa. Equivalent to Rv1483,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 247 aa overlap). Probable fabG1 (alternate gene name: mabA), 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100), equivalent to O07399|FABG_MYCAV 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Mycobacterium avium (255 aa); P71534|FABG_MYCSM 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Mycobacterium smegmatis (255 aa); and NP_302228.1|NC_002677 3-oxoacyl-[ACP] reductase (aka MabA) from Mycobacterium leprae (253 aa). Also highly similar to many e.g. T36779 probable 3-oxacyl-(acyl-carrier-protein) reductase from Streptomyces coelicolor (234 aa); FABG_ECOLI|P25716|NP_415611.1|NC_000913 3-oxoacyl-[acyl-carrier-protein] reductase from Escherichia coli strain K12 (244 aa), FASTA scores: opt: 664, E(): 6.8e-35, (44.4% identity in 241 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	X2BHS3,P0A5Y5,P0A5Y5	No				P0A5Y5					X2BHS3,P0A5Y5										
NC_002945.3	Mycobrowser_v4	CDS	1670948	1671757	.	+	0	Mb1520	inhA		NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	Mb1520, inhA, len: 269 aa. Equivalent to Rv1484,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 269 aa overlap). inhA, NADH-dependent enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.9) (see citations below). Identical to INHA_MYCTU|P46533 enoyl-[acyl-carrier-protein] reductase from Mycobacterium tuberculosis and G1155270 Mycobacterium bovis enoyl acp reductase. SOME SIMILARITY TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	X2BIC8,P0A5Y7,P0A5Y7	No	lipid metabolism			P0A5Y7					X2BIC8,P0A5Y7					Rv1484		Rv1484			
NC_002945.3	Mycobrowser_v4	CDS	1671763	1672797	.	+	0	Mb1521	hemZ		FERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME SYNTHETASE)	Mb1521, hemZ, len: 344 aa. Equivalent to Rv1485,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 344 aa overlap). hemZ, ferrochelatase (EC 4.99.1.1) (see citation below), similar to many e.g. HEMZ_BACSU|P32396 ferrochelatase from Bacillus subtilus (310 aa), FASTA scores: opt:490, E(): 2e-24, (30.2% identity in 295 aa overlap); etc. BELONGS TO THE FERROCHELATASE FAMILY.	X2BI24,P0A577,P0A577	No	intermediary metabolism and respiration			P0A577					X2BI24,P0A577					Rv1485		Rv1485			
NC_002945.3	Mycobrowser_v4	CDS	1678903	1680750	.	+	0	Mb1529	mutA		PROBABLE METHYLMALONYL-COA MUTASE SMALL SUBUNIT MUTA (MCM)	Mb1529, mutA, len: 615 aa. Equivalent to Rv1492,len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 615 aa overlap). Probable mutA,Methylmalonyl-coa mutase small-subunit (EC 5.4.99.2),strong similarity to e.g. MUTA_STRCM|Q05064 methylmalonyl-coa mutase beta-subunit from Streptomyces cinnamonensis (616 aa), FASTA scores: opt: 1512, E(): 0,(45.9% identity in 628 aa overlap). Contains PS00213 Lipocalin signature, PS00544 Methylmalonyl-CoA mutase signature. BELONGS TO THE METHYLMALONYL-COA MUTASE FAMILY.	X2BHS9,P65486,P65486	No	lipid metabolism			P65486					X2BHS9,P65486					Rv1492		Rv1492			
NC_002945.3	Mycobrowser_v4	CDS	1680751	1683003	.	+	0	Mb1530	mutB		PROBABLE METHYLMALONYL-COA MUTASE LARGE SUBUNIT MUTB (MCM)	Mb1530, mutB, len: 750 aa. Equivalent to Rv1493,len: 750 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 750 aa overlap). Probable mutB,Methylmalonyl-coa mutase large-subunit (EC 5.4.99.2),strong similarity to e.g. MUTB_STRCM|Q05065 methylmalonyl-coa mutase alpha-subunit from Streptomyces cinnamonensis (733 aa), FASTA scores: opt: 3562, E(): 0,(75.8% identity in 730 aa overlap). Contains PS00544 Methylmalonyl-CoA mutase signature. BELONGS TO THE METHYLMALONYL-COA MUTASE FAMILY.	X2BID6,P65488,P65488	No	lipid metabolism			P65488					X2BID6,P65488					Rv1493		Rv1493			
NC_002945.3	Mycobrowser_v4	CDS	1683017	1683319	.	+	0	Mb1531	maze4		possible antitoxin maze4	Mb1531, -, len: 100 aa. Equivalent to Rv1494, len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 100 aa overlap). Hypothetical unknown protein.	X2BI30,P0A5F0	No	virulence, detoxification, adaptation			P0A5F0					X2BI30					Rv1494		Rv1494			
NC_002945.3	Mycobrowser_v4	CDS	1683316	1683633	.	+	0	Mb1532	mazf4		possible toxin mazf4	Mb1532, -, len: 105 aa. Equivalent to Rv1495, len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 105 aa overlap). Conserved hypothetical protein, some similarity to Rv1942c|MTCY09F9.22 hypothetical protein from Mycobacterium tuberculosis (109 aa) (0.7% identity in 101 aa overlap) and Rv0659c,Rv1102c.	X2BIK0,P64860,P64860	No	virulence, detoxification, adaptation			P64860					X2BIK0,P64860					Rv1495		Rv1495			
NC_002945.3	Mycobrowser_v4	CDS	1801555	1802973	.	+	0	Mb1643	pykA		Probable pyruvate kinase pykA	Mb1643, pykA, len: 472 aa. Equivalent to Rv1617,len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 472 aa overlap). Probable pykA,pyruvate kinase (EC 2.7.1.40). FASTA best: Q46078 PYRUVATE KINASE from CORYNEBACTERIUM GLUTAMICUM (475 aa), opt: 2221, E(): 0, (72.2% identity in 468 aa overlap). BELONGS TO THE PYRUVATE KINASE FAMILY.	Q7VEW3,A0A1R3XYV1	No	intermediary metabolism and respiration			A0A1R3XYV1				IPR001697,IPR011037,IPR015793,IPR015794,IPR015795,IPR015806,IPR015813	Q7VEW3					Rv1617		Rv1617			
NC_002945.3	Mycobrowser_v4	CDS	1763225	1763905	.	+	0	Mb1597	bioD		dethiobiotin synthetase biod	Mb1597, bioD, len: 226 aa. Equivalent to Rv1570,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 226 aa overlap). Probable bioD,dethiobiotin synthetase (EC 6.3.3.3). Similar to many e.g. BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa),FASTA results: opt: 1059, E(): 0, (74.8% identity in 222 aa overlap). BELONGS TO THE DETHIOBIOTIN SYNTHETASE FAMILY.	X2BIR2,O52587,O52587	No	intermediary metabolism and respiration			O52587					X2BIR2,O52587					Rv1570		Rv1570			
NC_002945.3	Mycobrowser_v4	CDS	1684687	1685976	.	+	0	Mb1534	lipL		PROBABLE ESTERASE LIPL	Mb1534, lipL, len: 429 aa. Equivalent to Rv1497,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 429 aa overlap). Probable LipL, esterase (EC 3.1.-.-), very similar to Mycobacterium tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923, Rv2463, Rv3775, etc. Also similar to G151214|M68491 esterase estA from Pseudomonas sp (389 aa),FASTA scores: opt: 604, E(): 1e-31, (34.4% identity in 389 aa overlap).	Q7TZZ1,A0A1R3XYJ7	No	intermediary metabolism and respiration			A0A1R3XYJ7				IPR001466,IPR012338	Q7TZZ1					Rv1497		Rv1497			
NC_002945.3	Mycobrowser_v4	CDS	1751572	1753314	.	-	0	Mb1588c	treZ		Maltooligosyltrehalose trehalohydrolase TreZ	Mb1588c, treZ, len: 580 aa. Equivalent to Rv1562c,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 580 aa overlap). treZ (previously called glgZ), Maltooligosyltrehalose trehalohydrolase,confirmed biochemically (see citation below). Similar to Q44316|D63343 TREZ MALTOOLIGOSYL TREHALOSE TREHALOHYDROLASE from ARTHROBACTER SP (598 aa), FASTA scores: opt: 2071, E(): 0, (52.2% identity in 582 aa overlap); also similar to 1,4-alpha-glucan branching enzymes e.g. GLGB_BACST|P30538 (639 aa), FASTA scores: opt: 313, E(): 3.8e-13, (27.5% identity in 462 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv1326c|glgB, and Rv1563c treY (previously glgY).	Q7VEY8,A0A1R3XYM9	No				A0A1R3XYM9				IPR006047,IPR012768,IPR013781,IPR013783,IPR014756,IPR015902,IPR017853,IPR022567	Q7VEY8										
NC_002945.3	Mycobrowser_v4	CDS	1698302	1701625	.	-	0	Mb1549c	mmpL12		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL12	Mb1549c, mmpL12, len: 1107 aa. Equivalent to Rv1522c, len: 1146 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1107 aa overlap). Probable mmpL12, conserved transmembrane transport protein (see first citation below), member of RND superfamily. Strong similarity to many Mycobacterial membrane proteins e.g. Q49619|G466786 putative transport protein B1170_C1_181 from Mycobacterium leprae (1008 aa), FASTA scores: opt: 2418, E(): 0, (51.0% identity in 1006 aa overlap); etc. Also highly similar to MmpL8|MTCY48.08c|Rv3823c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis, FASTA score: (34.3% identity in 376 aa overlap); and some similarity to MmpL10|MTCY20G9|Rv1183 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN, FASTA score: (27.2% identity in 1011 aa overlap). BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (c-a) omitting a stop codon,leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa).	Q7TZY0,A0A1R3XYJ9	No				A0A1R3XYJ9				IPR000731,IPR004707,IPR004869	Q7TZY0										
NC_002945.3	Mycobrowser_v4	CDS	1750927	1751145	.	+	0	Mb1586	vapb11		possible antitoxin vapb11	Mb1586, -, len: 72 aa. Equivalent to Rv1560, len: 72 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 72 aa overlap). Conserved hypothetical protein, part of a Mycobacterial tuberculosis family of proteins e.g. Q10848|Rv2009|MTCY39.08c (80 aa), FASTA score: (54.4% identity in 68 aa overlap); Q10799|Rv2871|MTCY274.02 (85 aa); O50456|Rv1241|MTV006.13 (86 aa), O06243|Rv2132|MTCY270.36C (76 aa); etc.	X2BI78,P64878	No	virulence, detoxification, adaptation			P64878					X2BI78					Rv1560		Rv1560			
NC_002945.3	Mycobrowser_v4	CDS	1696315	1698066	.	+	0	Mb1548	fadD25		probable fatty-acid-amp ligase fadd25 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb1548, fadD25, len: 583 aa. Equivalent to Rv1521,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 583 aa overlap). Probable fadD25,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to many e.g. P71495|U75685 ACYL-CoA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486,E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc.	Q7TZY1,A0A1R3XYJ1	No				A0A1R3XYJ1				IPR000873	Q7TZY1										
NC_002945.3	Mycobrowser_v4	CDS	1725225	1726205	.	-	0	Mb1565c	ansA		Probable L-aparaginase ansA	Mb1565c, ansA, len: 326 aa. Equivalent to Rv1538c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 326 aa overlap). Probable ansA,L-aparaginase, most similar to ASPG_BACLI|P30363 L-asparaginase (322 aa), FASTA scores: opt: 417, E(): 8.8e-19, (30.9% identity in 314 aa overlap). Contains PS00917 Asparaginase / glutaminase active site signature 2.	X2BIG6,P63628,P63628	No				P63628					X2BIG6,P63628										
NC_002945.3	Mycobrowser_v4	CDS	1704030	1704815	.	+	0	Mb1552	wbbL2		POSSIBLE RHAMNOSYL TRANSFERASE WBBL2	Mb1552, wbbL2, len: 261 aa. Equivalent to Rv1525,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 261 aa overlap). Possible wbbL2,rhamnosyl transferase (EC 2.-.-.-), showing weak similarity to several rhamnosyl transferases. Similar to AF105060|AF105060_1 Riftia pachyptila endosymbiont (746 aa), FASTA scores: opt: 183, E(): 0.00013, (35.2% identity in 105 aa overlap).	X2BIL7,P64868	No				P64868					X2BIL7										
NC_002945.3	Mycobrowser_v4	CDS	1706096	1712422	.	-	0	Mb1554c	pks5		Probable polyketide synthase pks5	Mb1554c, pks5, len: 2108 aa. Equivalent to Rv1527c,len: 2108 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 2108 aa overlap). Probable pks5,polyketide synthase, highly similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from Mycobacterium bovis (2110 aa), FASTA scores: opt: 6270,E(): 0, (63.6% identity in 2126 aa overlap).	Q7VEZ3,A0A1R3XYL5	No				A0A1R3XYL5				IPR001227,IPR009081,IPR011032,IPR013149,IPR013154,IPR013968,IPR014030,IPR014031,IPR014043,IPR016035,IPR016036,IPR016038,IPR016039,IPR016040,IPR018201,IPR020801,IPR020807,IPR020842,IPR020843	Q7VEZ3										
NC_002945.3	Mycobrowser_v4	CDS	1712966	1713463	.	-	0	Mb1555c	papA4		PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA4	Mb1555c, papA4, len: 165 aa. Equivalent to Rv1528c,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 165 aa overlap). Probable papA4,conserved polyketide synthase (PKS) associated protein; shows some similarity to C-terminal part of hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. Z97188|MTCY409_10 Mycobacterium tuberculosis cosmid (468) (37.9% identity in 66 aa overlap); or U00010_11 Mycobacterium leprae cosmid B1170 (35.7% identity in 84 aa overlap). Also similar to Mycobacterium tuberculosis PKS-associated proteins Rv1182, Rv3824c,Rv3820c.	Q7TZX9,A0A1R3XYL0	No				A0A1R3XYL0					Q7TZX9										
NC_002945.3	Mycobrowser_v4	CDS	1713515	1715269	.	+	0	Mb1556	fadD24		probable fatty-acid-amp ligase fadd24 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb1556, fadD24, len: 584 aa. Equivalent to Rv1529,len: 584 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 584 aa overlap). Probable fadD24,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA score: (65.6% identity in 582 aa overlap); and many other fatty-acid-CoA synthetases from Mycobacteria e.g. fadD25|MTCY19G5_7 from Mycobacterium tuberculosis (583 aa), FASTA score: (68.7% identity in 584 aa overlap); fadD28|MTCY24G1_8 from Mycobacterium tuberculosis (580 aa), FASTA score: (66.0% identity in 582 aa overlap); NP_301232.1|NC_002677|U00010_6 from Mycobacterium leprae (372 aa), FASTA score: (57.6% identity in 342 aa overlap); FADD23|Rv3826|MTCY409.04c from Mycobacterium tuberculosis (584 aa), FASTA score: (63.2% identity in 584 aa overlap); etc.	Q7TZX8,A0A1R3XYJ8	No				A0A1R3XYJ8				IPR000873	Q7TZX8										
NC_002945.3	Mycobrowser_v4	CDS	1715386	1716489	.	+	0	Mb1557	adh		Probable alcohol dehydrogenase adh	Mb1557, adh, len: 367 aa. Equivalent to Rv1530,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 367 aa overlap). Probable adh, alcohol dehydrogenase (EC 1.1.1.1), zinc-dependent, similar to many e.g. AE0009|AE000958_23 Archaeoglobus fulgidus section 1 (402 aa), FASTA scores: opt: 423, E(): 1.8e-19,(31.7% identity in 341 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature.	Q7VEZ2,A0A1R3XYL6	No	intermediary metabolism and respiration			A0A1R3XYL6				IPR002085,IPR002328,IPR011032,IPR013149,IPR013154,IPR016040	Q7VEZ2					Rv1530		Rv1530			
NC_002945.3	Mycobrowser_v4	CDS	1723869	1725260	.	+	0	Mb1564	dinX		probable dna polymerase iv dinx (pol iv 1) (dna nucleotidyltransferase (dna-directed))	Mb1564, dinX, len: 463 aa. Equivalent to Rv1537,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 463 aa overlap). Probable dinX, DNA polymerase IV. Similar to umuC, mucB, samb, and impb (uv protection and mutation) e.g. IMPB_SALTY|P18642 impb protein from Salmonella typhimurium (424 aa), FASTA scores, opt: 386, E(): 1.7e-17, (27.5% identity in 415 aa overlap). Also similar to Mycobacterium tuberculosis Rv3056.	X2BHV7,P63986,P63986	No	information pathways			P63986					X2BHV7,P63986					Rv1537		Rv1537			
NC_002945.3	Mycobrowser_v4	CDS	1726257	1726865	.	+	0	Mb1566	lspA		Probable lipoprotein signal peptidase lspA	Mb1566, lspA, len: 202 aa. Equivalent to Rv1539,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 202 aa overlap). Probable lspA,lipoprotein signal peptidase (EC 3.4.23.36), similar to several e.g. LSPA_PSEFL|P17942 (170 aa), FASTA scores: opt: 299, E(): 2.6e-12, (38.3% identity in 167 aa overlap).	X2BI59,P65263,P65263	No	cell wall and cell processes			P65263					X2BI59,P65263					Rv1539		Rv1539			
NC_002945.3	Mycobrowser_v4	CDS	2086393	2086809	.	-	0	Mb1877c	blai		transcriptional repressor blai	Mb1877c, -, len: 138 aa. Equivalent to Rv1846c,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 138 aa overlap). Possible transcriptional regulatory protein. Equivalent to MLCB1788.17|AL008609 hypothetical protein from Mycobacterium leprae (142 aa), FASTA scores: opt: 736 E(): 0, (95.1% identity in 123 aa overlap). Also similar to BLAI_BACLI|P06555 penicillinase repressor (128 aa), fasta scores: opt: 114, E(): 0.12, (23.7% identity in 131 aa overlap).	Q7TZF9,A0A1R3XZH1	No	regulatory proteins			A0A1R3XZH1				IPR005650,IPR011991	Q7TZF9					Rv1846c		Rv1846c			
NC_002945.3	Mycobrowser_v4	CDS	1731707	1735261	.	+	0	Mb1574	dnaE1		probable dna polymerase iii (alpha chain) dnae1 (dna nucleotidyltransferase)	Mb1574, dnaE1, len: 1184 aa. Equivalent to Rv1547,len: 1184 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 1184 aa overlap). Probable dnaE1,DNA polymerase III, alpha chain (EC 2.7.7.7), similar to e.g. DP3A_ECOLI|P10443 dna polymerase III, alpha chain (1160 aa), FASTA scores: opt: 1789, E(): 0, (36.5% identity in 1193 aa overlap). Also similar to M. tuberculosis, DnaE2|Rv3370c.	X2BHX1,P63978,P63978	No				P63978					X2BHX1,P63978										
NC_002945.3	Mycobrowser_v4	CDS	1735310	1737346	.	-	0	Mb1575c	PPE21		ppe family protein ppe21	Mb1575c, PPE21, len: 678 aa. Equivalent to Rv1548c,len: 678 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 678 aa overlap). Member of the M. tuberculosis PPE family, similar to several e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kd protein in hsp65 3' region (517 aa), FASTA scores: opt:1142, E(): 0, (40.6% identity in 616 aa overlap); also similar to MTCY31.06c (54.9% identity in 381 aa overlap).	Q7TZX3,A0A1R3XYN6	No				A0A1R3XYN6				IPR000030,IPR002989	Q7TZX3										
NC_002945.3	Mycobrowser_v4	CDS	1739460	1741325	.	+	0	Mb1577	plsB1		Possible acyltransferase plsB1	Mb1577, plsB1, len: 621 aa. Equivalent to Rv1551,len: 621 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 621 aa overlap). Possible plsB1,acyltransferase (EC 2.-.-.-), similar to PLSB_HAEIN|P44857 glycerol-3-phosphate acyltransferase from Haemophilus influenzae (810 aa), FASTA scores: opt: 434, E(): 6.2e-22,(27.6% identity in 395 aa overlap). Also similar to Rv2482c|plsB2 Probable glycerol-3-phosphate acyltransferase from M.tuberculosis (789 aa).	X2BIP2,P65735,P65735	No				P65735					X2BIP2,P65735										
NC_002945.3	Mycobrowser_v4	CDS	1741696	1743447	.	+	0	Mb1578	frdA		PROBABLE FUMARATE REDUCTASE [FLAVOPROTEIN SUBUNIT] FRDA (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)	Mb1578, frdA, len: 583 aa. Equivalent to Rv1552,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 583 aa overlap). Probable frdA, fumarate reductase, flavoprotein subunit (EC 1.3.99.1), highly similar to others e.g. P00363|FRDA_ECOLI fumarate reductase flavoprotein subunit from Escherichia coli strain K12 (601 aa), FASTA scores: opt: 2102, E(): 0,(54.7% identity in 585 aa overlap); NP_232284.1|NC_002505 fumarate reductase, flavoprotein subunit from Vibrio cholerae (602 aa); frdA|NP_438995.1|NC_000907 fumarate reductase, flavoprotein subunit from Haemophilus influenzae (599 aa); etc. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD).	X2BIA5,P64175,P64175	No	intermediary metabolism and respiration			P64175					X2BIA5,P64175					Rv1552		Rv1552			
NC_002945.3	Mycobrowser_v4	CDS	1749600	1750889	.	+	0	Mb1585	ilvA		Probable threonine dehydratase ilvA	Mb1585, ilvA, len: 429 aa. Equivalent to Rv1559,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 429 aa overlap). Probable ilvA,threonine dehydratase (EC 4.3.1.19), biosynthetic protein,similar to several e.g. THD1_CORGL|Q04513 threonine dehydratase biosynthetic (436 aa), FASTA scores: opt: 1694, E(): 0, (61.9% identity in 415 aa overlap). Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.	X2BII6,P66898,P66898	No	intermediary metabolism and respiration			P66898					X2BII6,P66898					Rv1559		Rv1559			
NC_002945.3	Mycobrowser_v4	CDS	1743450	1744574	.	+	0	Mb1579	frdBC		probable fumarate reductase [membrane anchor subunit] frdc (fumarate dehydrogenase) (fumaric hydrogenase)	Mb1579, frdBC, len: 374 aa. Equivalent to Rv1553 (frdB) and Rv1554 (frdC), len: 247 aa and len: 126 aa,from Mycobacterium tuberculosis strain H37Rv, (100% identity in 247 aa overlap and 99.2% identity in 126 aa overlap). Probable frdB, fumarate reductase, iron-sulfur subunit (EC 1.3.99.1), highly similar to others e.g. P00364|FRDB_ECOLI fumarate reductase iron-sulfur protein from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 846, E(): 0, (50.0% identity in 242 aa overlap); P20921|FRDB_PROVU FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Proteus vulgaris (245 aa); G64097 fumarate reductase (EC 1.3.99.1) iron-sulfur protein from Haemophilus influenzae (276 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. And probable frdC, fumarate reductase, membrane-anchor subunit (EC 1.3.99.1), highly similar to others e.g. P03805|FRDC_ECOLI fumarate reductase 15 kDa hydrophobic protein from Escherichia coli strain K12 (131 aa), FASTA scores, opt: 268, E(): 3.9e-10, (31.1% identity in 122 aa overlap); NP_458780.1|NC_003198 fumarate reductase complex subunit C; membrane anchor polypeptide from Salmonella enterica subsp. enterica serovar Typhi (131 aa); P20923|FRDC_PROVU FUMARATE REDUCTASE 15 KD HYDROPHOBIC PROTEIN from Proteus vulgaris (131 aa); etc. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg) leads to a single product.	Q7TZX1,A0A1R3XYM8	No	intermediary metabolism and respiration			A0A1R3XYM8				IPR001041,IPR003510,IPR004489,IPR009051,IPR012675,IPR017896,IPR017900,IPR025192	Q7TZX1					Rv1553		Rv1553			
NC_002945.3	Mycobrowser_v4	CDS	1744571	1744948	.	+	0	Mb1580	frdD		PROBABLE FUMARATE REDUCTASE [MEMBRANE ANCHOR SUBUNIT] FRDD (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)	Mb1580, frdD, len: 125 aa. Equivalent to Rv1555,len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 125 aa overlap). Probable frdD, fumarate reductase, membrane-anchor subunit (EC 1.3.99.1), similar to others e.g. P03806|FRDD_ECOLI fumarate reductase 13 kDa hydrophobic protein from Escherichia coli strain K12 (119 aa), FASTA scores: opt: 212, E(): 4.4e-08, (36.8% identity in 106 aa overlap); etc. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD).	X2BII1,P67644,P67644	No	intermediary metabolism and respiration			P67644					X2BII1,P67644					Rv1555		Rv1555			
NC_002945.3	Mycobrowser_v4	CDS	1745763	1746209	.	+	0	Mb1582	mmpS6		PROBABLE CONSERVED MEMBRANE PROTEIN MMPS6	Mb1582, mmpS6, len: 148 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv. Probable mmpS6,conserved membrane protein (see citations below), highly similar to other Mycobacterial proteins e.g. P54880|MMS4_MYCLE|ML2377|U1740W|MMPS4 Putative membrane protein from Mycobacterium leprae (154 aa), FASTA scores: opt: 521, E(): 4.7e-29, (53.06% identity in 147 aa overlap); P95212|MMPS1|MMS1_MYCTU|Rv0403c|MT0415|MTCY04D9.16c PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 518, E(): 7.2e-29, (56.75% identity in 141 aa overlap); O53736|MMS4_MYCTU|MMPS4|Rv0451c|MT0467|MTV037.15c PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium tuberculosis (140 aa), FASTA scores: opt: 498, E(): 1.8e-27, (52.85% identity in 140 aa overlap); etc. BELONGS TO THE MMPS FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region.	Q7TZX0,A0A1R3XYN3	No				A0A1R3XYN3				IPR008693	Q7TZX0										
NC_002945.3	Mycobrowser_v4	CDS	1746206	1749109	.	+	0	Mb1583	mmpL6		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL6	Mb1583, mmpL6, len: 967 aa. Equivalent to 3' end of Rv1557, len: 397 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 384 aa overlap). Probable mmpL6, conserved transmembrane transport protein (see citations below). Member of RND superfamily, with strong similarity to other members of large Mycobacterial membrane protein family belonging to RND superfamily e.g. Q11171|MML2_MYCTU|MMPL2|Rv0507|MT0528|MTCY20G9.34 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 4142, E(): 0, (64.4% identity in 947 aa overlap); O53735|MML4_MYCTU|MMPL4|Rv0450c|MT0466|MTV037.14c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis (967 aa), FASTA scores: opt: 4035, E(): 0, (61.5% identity in 948 aa overlap); P54881|MML4_MYCLE|MMPL4|ML2378|U1740V Putative membrane protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3961, E(): 0, (60.95% identity in 945 aa overlap); etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region.	Q7TZW9,A0A1R3XZ18	No				A0A1R3XZ18				IPR000731,IPR004707,IPR004869	Q7TZW9										
NC_002945.3	Mycobrowser_v4	CDS	1753307	1754041	.	-	0	Mb1589c	treYb		Maltooligosyltrehalose synthase TreYb [SECOND PART]	Mb1589c, treYb, len: 244 aa. Equivalent to the 3' end of Rv1563c, len: 765 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 244 aa overlap). treY (previously called glgY), maltooligosyl trehalose synthase, confirmed biochemically (see citation below). Strong similarity to Q44315|63343 TREY MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775 aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in 789 aa overlap). Some similarity to alpha-amylases and to MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse conversion of maltodextrins to maltooligosyl trehaloses. Also similar to Mycobacterium tuberculosis glgB (Rv1326c),treZ (Rv1562c). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1563c/treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp splits Rv1563c into two parts, treYa and treYb.	Q7VEY7,A0A1R3XYN8	No				A0A1R3XYN8				IPR013781,IPR013797,IPR015902,IPR017853	Q7VEY7										
NC_002945.3	Mycobrowser_v4	CDS	1754046	1754798	.	-	0	Mb1590c	treYa		Maltooligosyltrehalose synthase TreYa [FIRST PART]	Mb1590c, treYa, len: 250 aa. Equivalent to the 5' end of Rv1563c, len: 765 aa, from Mycobacterium tuberculosis strain H37Rv, (97.4% identity in 191 aa overlap). treY (previously called glgY), maltooligosyl trehalose synthase, confirmed biochemically (see citation below). Strong similarity to Q44315|63343 TREY MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775 aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in 789 aa overlap). Some similarity to alpha-amylases and to MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse conversion of maltodextrins to maltooligosyl trehaloses. Also similar to Mycobacterium tuberculosis glgB (Rv1326c),treZ (Rv1562c). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1563c/treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp splits Rv1563c in two parts, treYa and treYb.	Q7VEY6,A0A1R3Y0U5	No				A0A1R3Y0U5				IPR006047,IPR013781,IPR015902,IPR017853	Q7VEY6										
NC_002945.3	Mycobrowser_v4	CDS	1754802	1756967	.	-	0	Mb1591c	treX		probable maltooligosyltrehalose synthase trex	Mb1591c, treX, len: 721 aa. Equivalent to Rv1564c,len: 721 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 721 aa overlap). Probable treX (previously called glgX), Maltooligosyltrehalose synthase. Strong similarity to D83245|g1890053 treX, glycogen debranching enzyme (glgX) from Sulfolobus acidocaldarius (713 aa), FASTA score: opt: 2396, E(): 0, (48.4% identity in 709 aa overlap); similar to GLGX_HAEIN|P45178 glycogen operon protein glgx (659 aa), FASTA scores: opt: 1512,E(): 0, (42.3% identity in 645 aa overlap).	X2BI83,P0A4Y5,P0A4Y5	No				P0A4Y5					X2BI83,P0A4Y5										
NC_002945.3	Mycobrowser_v4	CDS	1788030	1788650	.	+	0	Mb1628	hisH		Probable amidotransferase hisH	Mb1628, hisH, len: 206 aa. Equivalent to Rv1602,len: 206 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 206 aa overlap). Probable hisH,amidotransferase (EC 2.4.2.-). Similar to many e.g. HIS5_STRCO|P16249 from Streptomyces coelicolor (222 aa),FASTA results: opt: 872, E():0, (61.0% identity in 210 aa overlap). Contains glutamine amidotransferases class-I active site (PS00442). BELONGS TO THE HISH FAMILY.	X2BHZ9,P59957,P59957	No	intermediary metabolism and respiration			P59957					X2BHZ9,P59957					Rv1602		Rv1602			
NC_002945.3	Mycobrowser_v4	CDS	1760758	1762071	.	+	0	Mb1595	bioA		adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioa	Mb1595, bioA, len: 437 aa. Equivalent to Rv1568,len: 437 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 437 aa overlap). Probable bioA,adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62). Highly similar to BIOA_MYCLE|P4548 from M. leprae (436 aa), FASTA results: opt: 2534, E(): 0, (85.1% identity in 436 aa overlap). Also similar to other M. tuberculosis proteins e.g. MTCY227.12c (449 aa), FASTA score: E(): 3.5e-16, (29.5% identity in 421 aa overlap). Contains aminotransferases class-III pyridoxal-phosphate attachment site (PS00600). BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.	X2BIJ6,P0A4X7,P0A4X7	No	intermediary metabolism and respiration			P0A4X7					X2BIJ6,P0A4X7					Rv1568		Rv1568			
NC_002945.3	Mycobrowser_v4	CDS	1762068	1763228	.	+	0	Mb1596	bioF1		PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF1 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE)	Mb1596, bioF1, len: 386 aa. Equivalent to Rv1569,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 386 aa overlap). Probable bioF1,8-amino-7-oxononanoate synthase (EC 2.3.1.47), highly similar to BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa), FASTA results: opt: 1971, E(): 0, (80.1% identity in 381 aa overlap). Also similar to BIOF2|Rv0032|MTCY10H4.32 POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE from Mycobacterium tuberculosis (771 aa), FASTA score: E(): 5.5e-29, (37.4% identity in 393 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.	X2BI87,P0A4X5,P0A4X5	No				P0A4X5					X2BI87,P0A4X5										
NC_002945.3	Mycobrowser_v4	CDS	1775650	1776699	.	+	0	Mb1615	bioB		probable biotin synthetase biob	Mb1615, bioB, len: 349 aa. Equivalent to Rv1589,len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 349 aa overlap). bioB, biotin synthetase (EC 2.8.1.-) O06601. Highly similar to BIOB_MYCLE|P46715 BioB from Mycobacterium leprae (345 aa), FASTA results: opt: 1982, E(): 0, (86.5% identity in 349 aa overlap).	X2BIA2,P0A507,P0A507	No	intermediary metabolism and respiration			P0A507					X2BIA2,P0A507					Rv1589		Rv1589			
NC_002945.3	Mycobrowser_v4	CDS	2525442	2525759	.	-	0	Mb2297c	mazf8		possible toxin mazf8	Mb2297c, -, len: 105 aa. Equivalent to Rv2274c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 105 aa overlap). Unknown protein; questionable ORF	Q7TYV8,A0A1R3Y0N0	No	virulence, detoxification, adaptation			A0A1R3Y0N0					Q7TYV8					Rv2274c		Rv2274c			
NC_002945.3	Mycobrowser_v4	CDS	1780122	1781171	.	+	0	Mb1620	nadA		Probable quinolinate synthetase nadA	Mb1620, nadA, len: 349 aa. Equivalent to Rv1594,len: 349 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 349 aa overlap). Probable nadA,quinolinate synthetase. Similar to many e.g. Q49622 NADA from Mycobacterium leprae (368 aa), FASTA results: opt: 1994, E(): 0, (84.4% identity in 352 aa overlap).	X2BIA6,P65498,P65498	No	intermediary metabolism and respiration			P65498					X2BIA6,P65498					Rv1594		Rv1594			
NC_002945.3	Mycobrowser_v4	CDS	1781171	1782754	.	+	0	Mb1621	nadB		Probable L-aspartate oxidase nadB	Mb1621, nadB, len: 527 aa. Equivalent to Rv1595,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 527 aa overlap). Probable nadB,L-aspartate oxidase (EC 1.4.3.16). Similar to many e.g. Q49617 L-ASPARTATE OXIDASE (QUINOLINATE SYNTHETASE) from Mycobacterium leprae (424 aa), FASTA results: opt: 2152,E(): 0, (82.0% identity in 400 aa overlap). Also shows some similarity to Rv1552 frdA from Mycobacterium tuberculosis (583 aa), FASTA results: E(): 1e-10, (35.3% identity in 566 aa overlap). HETERODIMER. THE QUINOLINATE SYNTHETASE COMPLEX CONSISTS OF THE TWO ENZYMES QUINOLINATE SYNTHETASE A AND B. TBparse score is 0.896.	X2BIT0,P65500,P65500	No	intermediary metabolism and respiration			P65500					X2BIT0,P65500					Rv1595		Rv1595			
NC_002945.3	Mycobrowser_v4	CDS	1782754	1783611	.	+	0	Mb1622	nadC		Probable nicotinate-nucleotide pyrophosphatase nadC	Mb1622, nadC, len: 285 aa. Equivalent to Rv1596,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 285 aa overlap). Probable nadC,nicotinate-nucleotide pyrophosphatase (EC 2.4.2.19) O06594. Similar to many e.g. ADC_MYCLE|P46714 from Mycobacterium leprae (284 aa), FASTA results: opt: 1418,E(): 0,(79.2% identity in 283 aa overlap). BELONGS TO THE NADC/MODD FAMILY.	Q7VEW9,A0A1R3XZ55	No	intermediary metabolism and respiration			A0A1R3XZ55				IPR002638,IPR004393,IPR013785,IPR022412,IPR027277	Q7VEW9					Rv1596		Rv1596			
NC_002945.3	Mycobrowser_v4	CDS	1784949	1786265	.	+	0	Mb1625	hisD		Probable histidinol dehydrogenase HisD (HDH)	Mb1625, hisD, len: 438 aa. Equivalent to Rv1599,len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 438 aa overlap). Probable hisD,histidinol dehydrogenase (EC 1.1.1.23) (see citation below) O08396. Similar to many e.g. HISX_MYCSM|P28736 from Mycobacterium smegmatis (445 aa), FASTA results: opt: 2356, E(): 0, (83.1% identity in 437 aa overlap). Contains histidinol dehydrogenase signature (PS00611).	X2BIB0,P63951,P63951	No	intermediary metabolism and respiration			P63951					X2BIB0,P63951					Rv1599		Rv1599			
NC_002945.3	Mycobrowser_v4	CDS	1786262	1787404	.	+	0	Mb1626	hisC1		Probable histidinol-phosphate aminotransferase hisC1	Mb1626, hisC1, len: 380 aa. Equivalent to Rv1600,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 380 aa overlap). Probable hisC1,histidinol-phosphate aminotransferase (EC 2.6.1.9) O06591. Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces coelicolor (369 aa), FASTA results: opt: 1353, E(): 0,(59.0% identity in 356 aa overlap). Some similarity to other Mycobacterium tuberculosis aminotransferases e.g. Rv3772|MTCY13D12.06, FASTA results: E(): 7.4e-25, (33.7% identity in 365 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Note that previously known as hisC.	X2BIT4,P0A679,P0A679	No				P0A679					X2BIT4,P0A679										
NC_002945.3	Mycobrowser_v4	CDS	1787401	1788033	.	+	0	Mb1627	hisB		Probable imidazole glycerol-phosphate dehydratase hisB	Mb1627, hisB, len: 210 aa. Equivalent to Rv1601,len: 210 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 210 aa overlap). Probable hisB,imidazole glycerol-phosphate dehydratase (EC 4.2.1.19). Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0,(57.4% identity in 202 aa overlap). BELONGS TO THE IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE FAMILY.	X2BIE6,P64369,P64369	No	intermediary metabolism and respiration			P64369					X2BIE6,P64369					Rv1601		Rv1601			
NC_002945.3	Mycobrowser_v4	CDS	1788660	1789397	.	+	0	Mb1629	hisA		PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE HISA	Mb1629, hisA, len: 245 aa. Equivalent to Rv1603,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 245 aa overlap). Probable hisA,PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE (EC 5.3.1.16), similar to many e.g. HIS4_STRCO|P16250 phosphoribosylformimino-5-aminoimidaz from Streptomyces coelicolor (240 aa), FASTA scores: opt: 1081, E(): 0, (69.0% identity in 239 aa overlap).	X2BIN3,P60579,P60579	No	intermediary metabolism and respiration			P60579					X2BIN3,P60579					Rv1603		Rv1603			
NC_002945.3	Mycobrowser_v4	CDS	1789405	1790217	.	+	0	Mb1630	impA		PROBABLE INOSITOL-MONOPHOSPHATASE IMPA (IMP)	Mb1630, impA, len: 270 aa. Equivalent to Rv1604,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 270 aa overlap). Probable impA,inositol monophosphatase (EC 3.1.3.25), similar to many e.g. AF0059|AF005905_2 inositol monophosphate phosphatase from Mycobacterium smegmatis (276 aa), FASTA scores: opt: 1241, E(): 0, (70.5% identity in 261 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv3137 and Rv2701c.	Q7TZW1,A0A1R3XZP5	No	intermediary metabolism and respiration			A0A1R3XZP5				IPR000760,IPR020550	Q7TZW1					Rv1604		Rv1604			
NC_002945.3	Mycobrowser_v4	CDS	1790219	1791022	.	+	0	Mb1631	hisF		Probable cyclase hisF	Mb1631, hisF, len: 267 aa. Equivalent to Rv1605,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 267 aa overlap). Probable hisF, cyclase involved in histidine biosynthetic pathway, similar to many e.g. AF0304|AF030405_1 Corynebacterium glutamicum cyclase (257 aa), FASTA scores: opt: 1201, E(): 0, (71.9% identity in 256 aa overlap). BELONGS TO THE HISA / HISF FAMILY.	X2BIT7,Q7VEW8,Q7VEW8	No	intermediary metabolism and respiration			Q7VEW8					X2BIT7,Q7VEW8					Rv1605		Rv1605			
NC_002945.3	Mycobrowser_v4	CDS	1791547	1792629	.	+	0	Mb1633	chaA		Probable ionic transporter integral membrane protein chaA	Mb1633, chaA, len: 360 aa. Equivalent to Rv1607,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable chaA, ionic transporter integral membrane protein, putative calcium/proton antiporter, similar to many e.g. P31801|CHAA_ECOLI CALCIUM/PROTON ANTIPORTER from Escherichia coli (366 aa), FASTA scores: opt: 736, E(): 0,(35.9% identity in 351 aa overlap). Equivalent to Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity in 364 aa overlap). SEEMS TO BELONG TO THE CaCA FAMILY.	Q7VEW7,A0A1R3XYU2	No	cell wall and cell processes			A0A1R3XYU2				IPR004837	Q7VEW7					Rv1607		Rv1607			
NC_002945.3	Mycobrowser_v4	CDS	1792664	1793128	.	-	0	Mb1634c	bcpB		Probable peroxidoxin bcpB	Mb1634c, bcpB, len: 154 aa. Equivalent to Rv1608c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 154 aa overlap). Probable bcpB,peroxidoxin or bacterioferritin comigratory protein,similar to many, e.g. AE0003|ECAE000335_4 bacterioferritin comigratory protein from Escherichia coli K-12 MG1655 (156 aa), FASTA scores: opt: 329, E(): 1.2e-16, (38.2% identity in 152 aa overlap); Z97179|MLCL383_22 Mycobacterium leprae cosmid L383 (161 aa) (40.2% identity in 132 aa overlap). Also similar to Rv2428 AhpC, alkyl hydroperoxide reductase from Mycobacterium tuberculosis; and other Mycobacterium tuberculosis putative peroxidoxins Rv2521, Rv2238c,Rv1932.	Q7VEW6,A0A1R3XYU8	No				A0A1R3XYU8				IPR000866,IPR012336	Q7VEW6										
NC_002945.3	Mycobrowser_v4	CDS	1793269	1794819	.	+	0	Mb1635	trpE		anthranilate synthase component i trpe (glutamine amidotransferase)	Mb1635, trpE, len: 516 aa. Equivalent to Rv1609,len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 516 aa overlap). Probable trpE,anthranilate synthase component I (EC 4.1.3.27). FASTA best: TRPE_CLOTM|P14953 anthranilate synthase component I from Clostridium thermocellum (494 aa), E(): 0, (42.6% identity in 498 aa overlap). Some similarity to Rv2386c|MTCY253.35, E(): 6.3e-17; and Rv3215|MTCY07D11.11c, E(): 5.7e-15. BELONGS TO THE ANTHRANILATE SYNTHASE COMPONENT I FAMILY.	X2BIC2,P67002,P67002	No	intermediary metabolism and respiration			P67002					X2BIC2,P67002					Rv1609		Rv1609			
NC_002945.3	Mycobrowser_v4	CDS	1860690	1867070	.	+	0	Mb1689	pks7		Probable polyketide synthase pks7	Mb1689, pks7, len: 2126 aa. Equivalent to Rv1661,len: 2126 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 2126 aa overlap). Probable pks7,polyketide synthase, similar to many e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa), FASTA scores: E(): 0, (48.8% identity in 2131 aa overlap); also similar to Mycobacterium tuberculosis pks12. Contains PS00606 Beta-ketoacyl synthases active site, PS00012 Phosphopantetheine attachment site.	Q7VEV1,A0A1R3XYY8	No				A0A1R3XYY8				IPR001227,IPR006162,IPR009081,IPR011032,IPR013149,IPR013154,IPR013968,IPR014030,IPR014031,IPR014043,IPR016035,IPR016036,IPR016038,IPR016039,IPR016040,IPR018201,IPR020801,IPR020806,IPR020807,IPR020841,IPR020842,IPR020843	Q7VEV1										
NC_002945.3	Mycobrowser_v4	CDS	1795606	1796424	.	+	0	Mb1637	trpC		Probable indole-3-glycerol phosphate synthase trpC	Mb1637, trpC, len: 272 aa. Equivalent to Rv1611,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 272 aa overlap). Probable trpC,indole-3-glycerol phosphate synthase (EC 4.1.1.48). Similar to Q55508|SLR0546 HYPOTHETICAL 33.0 KD PROTEIN from SYNECHOCYSTIS SP (295 aa), FASTA score: opt: 26, E(): 7.6e-32, (44.2% identity in 265 aa overlap); also similar to TRPC_AZOBR|P26938 indole-3-glycerol-phosphate synthaseindole-3-glycerol-phosphate synthase from Azospirillum brasilense (262 aa), FASTA score: opt: 596,E(): 4.8e-30, (43.8% identity in 258 aa overlap). Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium leprae (272 aa) (90.8% identity in 272 aa overlap). Contains indole-3-glycerol phosphate synthase signature (PS00614). BELONGS TO THE TRPC FAMILY.	X2BIF5,P0A633,P0A633	No	intermediary metabolism and respiration			P0A633					X2BIF5,P0A633					Rv1611		Rv1611			
NC_002945.3	Mycobrowser_v4	CDS	1796493	1797725	.	+	0	Mb1638	trpB		tryptophan synthase, beta subunit trpb	Mb1638, trpB, len: 410 aa. Equivalent to Rv1612,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 410 aa overlap). Probable trpB,tryptophan synthase beta chain (EC 4.2.1.20). Equivalent to AL049913|MLCB1610_25 from Mycobacterium leprae (340 aa) (88.5% identity in 331 aa overlap). Similar to others e.g. TRPB_CAUCR|P12290 tryptophan synthase beta chain from Caulobacter crescentus (406 aa), FASTA scores: opt: 1662,E(): 0, (60.6% identity in 404 aa overlap). BELONGS TO THE TRPB FAMILY. TETRAMER OF TWO ALPHA AND TWO BETA CHAINS.	X2BI05,P66985,P66985	No	intermediary metabolism and respiration			P66985					X2BI05,P66985					Rv1612		Rv1612			
NC_002945.3	Mycobrowser_v4	CDS	1797725	1798537	.	+	0	Mb1639	trpA		Probable tryptophan synthase, alpha subunit trpA	Mb1639, trpA, len: 270 aa. Equivalent to Rv1613,len: 270 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 270 aa overlap). Probable trpA,tryptophan synthase alpha chain (EC 4.2.1.20). FASTA best: O68906|TRPA_MYCIT TRYPTOPHAN SYNTHASE ALPHA CHAIN from Mycobacterium intracellulare (271 aa), opt: 1442, E(): 0,(85.3% identity in 265 aa overlap).	X2BIP3,P66981,P66981	No	intermediary metabolism and respiration			P66981					X2BIP3,P66981					Rv1613		Rv1613			
NC_002945.3	Mycobrowser_v4	CDS	1798537	1799943	.	+	0	Mb1640	lgt		Possible prolipoprotein diacylglyceryl transferases Lgt	Mb1640, lgt, len: 468 aa. Equivalent to Rv1614,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 468 aa overlap). Possible lgt,prolipoprotein diacylglyceryl transferases (EC 2.4.99.-),similar to many prolipoprotein diacylglyceryl transferases. FASTA scores: LGT_STAAU|P52282 prolipoprotein diacylglyceryl transferase from Staphylococcus aureus subsp. (279 aa), opt: 289, E():3.6e-09, (31.5% identity in 257 aa overlap); AL096884|SC4G6_3 cosmid 4G6 from Streptomyces coelicolor (343 aa), opt: 735, E(): 4e-32, (46.5% identity in 391 aa overlap).	X2BIC7,Q7VEW5,Q7VEW5	No	cell wall and cell processes			Q7VEW5					X2BIC7,Q7VEW5					Rv1614		Rv1614			
NC_002945.3	Mycobrowser_v4	CDS	1802981	1803883	.	+	0	Mb1644	tesB1		Probable acyl-CoA thioesterase II tesB1	Mb1644, tesB1, len: 300 aa. Equivalent to Rv1618,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 300 aa overlap). Probable tesB1,acyl-CoA thioesterase II (EC 3.1.2.-), similar to other acyl-CoA thioesterases e.g. TESB_ECOLI|P23911 acyl-coa thioesterase II from Escherichia coli (285 aa), FASTA scores: opt: 495, E(): 2.9e-27, (32.5% identity in 283 aa overlap); etc. Also similar to Rv2605c|tesB2 from M. tuberculosis.	Q7VEW2,A0A1R3XYV7	No				A0A1R3XYV7				IPR003703,IPR025652	Q7VEW2										
NC_002945.3	Mycobrowser_v4	CDS	1805329	1807059	.	-	0	Mb1646c	cydC		PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER CYDC	Mb1646c, cydC, len: 576 aa. Equivalent to Rv1620c,len: 576 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 576 aa overlap). Probable cydC,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. CYDC_ECOLI|P23886 transport ATP-binding protein from Escherichia coli (573 aa), FASTA scores: opt: 631, E(): 1.6e-30, (28.5% identity in 569 aa overlap); C-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FASTA scores: opt: 956, E(): 0, (38.8% identity in 554 aa overlap); etc. Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TZV7,A0A1R3XYV3	No				A0A1R3XYV3				IPR003439,IPR003593,IPR011527,IPR014223,IPR017871,IPR027417	Q7TZV7										
NC_002945.3	Mycobrowser_v4	CDS	1807056	1808639	.	-	0	Mb1647c	cydD		PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER CYDD	Mb1647c, cydD, len: 527 aa. Equivalent to Rv1621c,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 527 aa overlap). Probable cydD,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. P94366|CYDC_BACSU TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (567 aa), FASTA scores: opt: 784, E(): 0, (30.1% identity in 535 aa overlap); N-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa),FASTA scores: opt: 1295, E(): 0, (44.6% identity in 534 aa overlap); etc. Also similar to Q11019|Y07D_MYCTU from Mycobacterium tuberculosis (579 aa), FASTA scores: opt: 530, E(): 6.9e-25, (29.1% identity in 530 aa overlap). Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TZV6,A0A1R3XYT5	No				A0A1R3XYT5				IPR001140,IPR003439,IPR003593,IPR011527,IPR014216,IPR017871,IPR027417	Q7TZV6										
NC_002945.3	Mycobrowser_v4	CDS	1885637	1886371	.	-	0	Mb1702c	cmr		probable transcriptional regulatory protein cmr	Mb1702c, -, len: 244 aa. Equivalent to Rv1675c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 244 aa overlap). Probable transcriptional regulatory protein, weak similarity to D00496|LBATRP_7 trp operon from Lactobacillus casei (219 aa), FASTA scores: opt: 172, E(): 0.00011, (26.9% identity in 186 aa overlap).	Q7TZT5,A0A1R3XZ04	No	regulatory proteins			A0A1R3XZ04				IPR000595,IPR001808,IPR011991,IPR012318,IPR014710,IPR018490	Q7TZT5					Rv1675c		Rv1675c			
NC_002945.3	Mycobrowser_v4	CDS	1808726	1809766	.	-	0	Mb1648c	cydB		Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB (Cytochrome BD-I oxidase subunit II)	Mb1648c, cydB, len: 346 aa. Equivalent to Rv1622c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 346 aa overlap). Probable cydB,cytochrome D ubiquinol oxidase subunit II (EC 1.10.3.-),integral membrane protein, similar to others e.g. P11027|CYDB_ECOLI CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II from Escherichia coli strain K12 (379 aa), FASTA scores: opt: 519, E(): 0, (32.3% identity in 372 aa overlap); P94365|CYDB_BACSU CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II from Bacillus subtilis (338 aa), FASTA scores: opt: 824, E(): 0, (39.5% identity in 337 aa overlap); etc.	Q7TZV5,A0A1R3XYU5	No				A0A1R3XYU5				IPR003317	Q7TZV5										
NC_002945.3	Mycobrowser_v4	CDS	1809796	1811253	.	-	0	Mb1649c	cydA		Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA (Cytochrome BD-I oxidase subunit I)	Mb1649c, cydA, len: 485 aa. Equivalent to Rv1623c,len: 485 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 485 aa overlap). Probable cydA (previously known as appC, but renamed cydA to conform with Mycobacterium smegmatis nomenclature), cytochrome D ubiquinol oxidase subunit I (EC 1.10.3.-), integral membrane protein, similar to others e.g. P26459|APPC_ECOLI|CYXA|CBDA|B0978 CYTOCHROME BD-II OXIDASE SUBUNIT I from Escherichia coli strain K12 (514 aa), FASTA scores: opt: 870, E(): 0, (35.9% identity in 485 aa overlap); AL034355|SCD78_12 from Streptomyces coelicolor (501 aa), FASTA scores: opt: 1099, E(): 0, (48.6% identity in 510 aa overlap); etc.	Q7TZV4,A0A1R3Y0Z3	No				A0A1R3Y0Z3				IPR002585	Q7TZV4										
NC_002945.3	Mycobrowser_v4	CDS	1811980	1813236	.	-	0	Mb1651c	cya		MEMBRANE-ANCHORED ADENYLYL CYCLASE CYA (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE)	Mb1651c, cya, len: 418 aa. Equivalent to Rv1625c,len: 418 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 418 aa overlap). cya, membrane-anchored adenylyl cyclase (EC 4.6.1.1) (see citations below). C-terminal half is similar to region in numerous eukaryotic adenylate and guanylate cyclases. N-terminal half hydrophobic. FASTA score: CYG2_RAT|P22717 guanylate cyclase soluble, beta-2 chain (682 aa), FASTA scores: opt: 552, E(): 2.7e-26, (40.3% identity in 226 aa overlap). Some similarity to Rv2435c|MTCY428.11 from Mycobacterium tuberculosis (730 aa), E(): 7e-19. Start changed since first submission (+25 aa). BELONGS TO ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY.	X2BIV0,P0A4Y1,P0A4Y1	No				P0A4Y1					X2BIV0,P0A4Y1										
NC_002945.3	Mycobrowser_v4	CDS	1816031	1818745	.	+	0	Mb1655	polA		probable dna polymerase i pola	Mb1655, polA, len: 904 aa. Equivalent to Rv1629,len: 904 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 904 aa overlap). polA, DNA polymerase I (EC 2.7.7.7). Has DNA polymerase family A signature (PS00447) at C-terminal end. FASTA best: DPO1_MYCTU|Q07700 DNA polymerase I from Mycobacterium tuberculosis (904 aa). Some similarity to Rv2090|MTCY49.30 (393 aa), E(): 2.2e-18, (38.7% identity in 292 aa overlap). BELONGS TO DNA POLYMERASE TYPE-A FAMILY.	X2BIE3,P0A551,P0A551	No	information pathways			P0A551					X2BIE3,P0A551					Rv1629		Rv1629			
NC_002945.3	Mycobrowser_v4	CDS	1818908	1820353	.	+	0	Mb1656	rpsA		30s ribosomal protein s1 rpsa	Mb1656, rpsA, len: 481 aa. Equivalent to Rv1630,len: 481 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 481 aa overlap). Probable rpsA,ribosomal protein S1. FASTA best: RS1_MYCLE|P46836 30s ribosomal protein S1 from Mycobacterium leprae (482 aa),opt: 2655, E(): 0, (87.2% identity in 483 aa overlap).	Q7TZV2,A0A1R3XYW3	No	information pathways			A0A1R3XYW3				IPR000110,IPR003029,IPR012340,IPR022967	Q7TZV2					Rv1630		Rv1630			
NC_002945.3	Mycobrowser_v4	CDS	1820379	1821602	.	+	0	Mb1657	coaE		Probable dephospho-CoA kinase coaE (dephosphocoenzyme A kinase)	Mb1657, coaE, len: 407 aa. Equivalent to Rv1631,len: 407 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 407 aa overlap). Probable coaE,dephospho-CoA kinase (EC 2.7.1.24), similar to many e.g. Q50178|ML1383|COAE_MYCLE DEPHOSPHO-COA KINASE from Mycobacterium leprae (410 aa), FASTA scores: E(): 0,(77.5% identity in 409 aa overlap). Has ATP/GTP-binding site motif A (P-loop, PS00017) at N-terminus. IN THE N-TERMINAL SECTION; BELONGS TO THE COAE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE UPF0157 (GRPB) FAMILY.	X2BIH7,P63827,P63827	No	intermediary metabolism and respiration			P63827					X2BIH7,P63827					Rv1631		Rv1631			
NC_002945.3	Mycobrowser_v4	CDS	1822441	1824537	.	+	0	Mb1659	uvrB		probable excinuclease abc (subunit b-helicase) uvrb	Mb1659, uvrB, len: 698 aa. Equivalent to Rv1633,len: 698 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 698 aa overlap). uvrB, Excinuclease abc subunit B, has ATP/GTP-binding site motif A (P-loop; PS00017) near N-terminus. FASTA best: UVRB_MICLU|P10125 from Micrococcus luteus (709 aa), opt: 3268, E(): 0,(71.3% identity in 704 aa overlap). Also similar to M. tuberculosis Rv2973c (recG); and Rv1020 (mfd). BELONGS TO THE UVRB FAMILY.	X2BIR5,P67423,P67423	No	information pathways			P67423					X2BIR5,P67423					Rv1633		Rv1633			
NC_002945.3	Mycobrowser_v4	CDS	1827817	1828257	.	+	0	Mb1662	TB15.3		iron-regulated universal stress protein family protein tb15.3	Mb1662, TB15.3, len: 146 aa. Equivalent to Rv1636,len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). TB15.3, conserved hypothetical protein (see citations below), similar to other hypothetical proteins from diverse organisms e.g. Q57951|MJ0531|Y531_METJA from Methanococcus jannaschii (170 aa), FASTA scores: opt: 188, E(): 6e-06, (32.2% identity in 149 aa overlap); also P42297|YXIE_BACSU hypothetical 15.9 kd protein in bglh-wapa intergenic region precursor from Bacillus subtilis (148 aa), FASTA scores: opt: 162, E(): 0.00025, (30.8% identity in 156 aa overlap). Part of family of Mycobacterium tuberculosis hypothetical proteins (but lacks C-terminal region) including Rv2005c, Rv2623, Rv2026c, Rv1996, etc.	Q7TZU9,A0A1R3XZ92	No				A0A1R3XZ92				IPR006015,IPR006016,IPR014729	Q7TZU9										
NC_002945.3	Mycobrowser_v4	CDS	2525793	2526041	.	-	0	Mb2297A	mazE8		Possible antitoxin MazE8	Mb2297A, len: 82 aa. Equivalent to Rv2274A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazE8,antitoxin, part of toxin-antitoxin (TA) operon with Rv2274c (See Pandey and Gerdes, 2005).	X2BK86,A0A1R3Y0R0	No	virulence, detoxification, adaptation			A0A1R3Y0R0					X2BK86					Rv2274A		Rv2274A			
NC_002945.3	Mycobrowser_v4	CDS	1841129	1842061	.	+	0	Mb1673	PE17		pe family protein pe17	Mb1673, PE17, len: 310 aa. Equivalent to Rv1646,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 310 aa overlap). Member of the M. tuberculosis PE family of proteins, similar to many e.g. YW36_MYCTU|Q10873 hypothetical 53.7 kd protein cy39.36c (558 aa), FASTA scores, opt: 411, E(): 1.3e-15, (34.4% identity in 320 aa overlap).	Q7TZU5,A0A1R3XYX8	No	PE/PPE			A0A1R3XYX8				IPR000084	Q7TZU5					Rv1646		Rv1646			
NC_002945.3	Mycobrowser_v4	CDS	1829107	1832025	.	+	0	Mb1664	uvrA		probable excinuclease abc (subunit a-dna-binding atpase) uvra	Mb1664, uvrA, len: 972 aa. Equivalent to Rv1638,len: 972 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 972 aa overlap). uvrA, Excinuclease ABC subunit A, similar to many e.g. UVRA_ECOLI|P07671 excinuclease abc subunit a from Escherichia coli (940 aa),FASTA scores: opt: 2573, E(): 0, (56.2% identity in 951 aa overlap). Contains 2x PS00017 ATP/GTP-binding site motif A, PS00211 ABC transporters family signature, PS00211 ABC transporters family signature. CONSISTS OF THREE SUBUNITS; UVRA, UVRB AND UVRC. BELONGS TO THE ABC TRANSPORTER FAMILY. UVRA SUBFAMILY.	X2BIR9,P63381,P63381	No	information pathways			P63381					X2BIR9,P63381					Rv1638		Rv1638			
NC_002945.3	Mycobrowser_v4	CDS	1833883	1837401	.	-	0	Mb1667c	lysX		lysyl-trna synthetase 2 lysx	Mb1667c, lysX, len: 1172 aa. Equivalent to Rv1640c,len: 1172 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1172 aa overlap). Probable two domain protein, possible lysyl-tRNA synthetase 2 (EC 6.1.1.6). N-terminal part (bases 1850153 to 1852033) is similar to AL023861|SC3C8_3 hypothetical membrane protein from Streptomyces coelicolor (589 aa), Fasta scores: opt: 1426, E(): 0, (44.6% identity in 585 aa overlap). The C-terminal part is similar to SYK_CRILO|P37879 lysyl-tRNA synthetases (EC 6.1.1.6) from Cricetulus longicaudatus (Long-tailed hamster) (597 aa), Fasta scores, opt: 985,E(): 0, (36.8% identity in 524 aa overlap ). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1, PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. This may indicate a frame shift but sequence has been checked and no error found. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BII9,Q7VEV7,Q7VEV7	No				Q7VEV7					X2BII9,Q7VEV7										
NC_002945.3	Mycobrowser_v4	CDS	1837638	1838243	.	+	0	Mb1668	infC		PROBABLE INITIATION FACTOR IF-3 INFC	Mb1668, infC, len: 201 aa. Equivalent to Rv1641,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 201 aa overlap). Probable infC,initiation factor IF-3, similar to many e.g. IF3_BACST|P03000 initiation factor IF-3 from Bacillus stearothermophilus (171 aa), FASTA scores: opt: 560, E(): 1.9e-27, (50.6% identity in 166 aa overlap). Note that an AUC initiation codon has been used, the Bacillus (IF3_BACSU) and Escherichia coli (IF3_ECOLI) proteins use an AUU initiation codon, and the Myxococcus xanthus (DSG_MYXXA) homolog uses a AUC. BELONGS TO THE IF-3 FAMILY.	X2BI20,P65136,P65136	No	information pathways			P65136					X2BI20,P65136					Rv1641		Rv1641			
NC_002945.3	Mycobrowser_v4	CDS	1838293	1838487	.	+	0	Mb1669	rpmI		50S ribosomal protein L35 rpmI	Mb1669, rpmI, len: 64 aa. Equivalent to Rv1642,len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 64 aa overlap). rpmI, 50S ribosomal protein L35, similar to several e.g. RL35_SYNY3|P48959 from Synechocystis sp. (67 aa), fasta scores: opt: 179,E(): 2.7e-08, (51.6% identity in 64 aa overlap). BELONGS TO THE L35P FAMILY OF RIBOSOMAL PROTEINS.	X2BIS3,P66272,P66272	No	information pathways			P66272					X2BIS3,P66272					Rv1642		Rv1642			
NC_002945.3	Mycobrowser_v4	CDS	1838549	1838938	.	+	0	Mb1670	rplT		50S ribosomal protein L20 rplT	Mb1670, rplT, len: 129 aa. Equivalent to Rv1643,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). rplT, 50S ribosomal protein L20, similar to several e.g. RL20_ECOLI|P02421 from Escherichia coli (117 aa), FASTA scores: opt: 438,E(): 5.8e-24, (60.3% identity in 116 aa overlap). Contains PS00937 Ribosomal protein L20 signature.	X2BIF3,P66106,P66106	No	information pathways			P66106					X2BIF3,P66106					Rv1643		Rv1643			
NC_002945.3	Mycobrowser_v4	CDS	1838971	1839753	.	+	0	Mb1671	tsnR		Possible 23S rRNA methyltransferase tsnR	Mb1671, tsnR, len: 260 aa. Equivalent to Rv1644,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 260 aa overlap). Possible tsnR, 23S rRNA methyltransferase (EC 2.1.1.-), similar to several e.g. TSNR_STRLU|P52393 from Streptomyces laurentii (270 aa), FASTA scores: opt: 276, E(): 3.6e-11, (27.6% identity in 261 aa overlap). Also similar to M. tuberculosis hypothetical proteins Rv0881, Rv3579c, and Rv0380c.	Q7VEV6,A0A1R3XYX1	No	information pathways			A0A1R3XYX1				IPR001537,IPR013123	Q7VEV6					Rv1644		Rv1644			
NC_002945.3	Mycobrowser_v4	CDS	1844098	1845123	.	+	0	Mb1676	pheS		probable phenylalanyl-trna synthetase, alpha chain phes	Mb1676, pheS, len: 341 aa. Equivalent to Rv1649,len: 341 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 341 aa overlap). pheS,Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20),similar to several e.g. SYFA_ECOLI|P08312 from Escherichia coli (327 aa), FASTA scores: opt: 978, E(): 0, (46.5% identity in 331 aa overlap). Homology suggests this start site, but there is a potential rbs upstream of a gtg 30 bp upstream; contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. PHE-TRNA SYNTHETASE ALPHA CHAIN SUBFAMILY 1.	X2BIW8,Q7VEV4,Q7VEV4	No	information pathways			Q7VEV4					X2BIW8,Q7VEV4					Rv1649		Rv1649			
NC_002945.3	Mycobrowser_v4	CDS	1845123	1847618	.	+	0	Mb1677	pheT		probable phenylalanyl-trna synthetase, beta chain phet	Mb1677, pheT, len: 831 aa. Equivalent to Rv1650,len: 831 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 831 aa overlap). pheT,Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20),similar to several e.g. SYFB_ECOLI|P07395 from Escherichia coli (795 aa), FASTA scores: opt: 995, E(): 0, (31.8% identity in 847 aa overlap). BELONGS TO THE PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN FAMILY - SUBFAMILY 1.	X2BIJ8,Q7VEV3,Q7VEV3	No	information pathways			Q7VEV3					X2BIJ8,Q7VEV3					Rv1650		Rv1650			
NC_002945.3	Mycobrowser_v4	CDS	1847712	1850768	.	-	0	Mb1679c	PE_PGRS30		pe-pgrs family protein pe_pgrs30	Mb1679c, PE_PGRS30, len: 1018 aa. Equivalent to Rv1651c, len: 1011 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 1018 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 1757, E(): 0, (50.8% identity in 714aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa).	Q7TZU3,A0A1R3XYX7	No				A0A1R3XYX7				IPR000084	Q7TZU3										
NC_002945.3	Mycobrowser_v4	CDS	1850962	1852020	.	+	0	Mb1680	argC		probable n-acetyl-gamma-glutamyl-phoshate reductase argc	Mb1680, argC, len: 352 aa. Equivalent to Rv1652,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 352 aa overlap). Probable argC,N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38),similar to many e.g. ARGC_STRCL|P54896 from Streptomyces clavuligerus (340 aa) , FASTA scores: opt: 1119, E(): 0,(56.9% identity in 350 aa overlap); etc. BELONGS TO THE NAGSA DEHYDROGENASE FAMILY.	X2BIT1,P63563,P63563	No	intermediary metabolism and respiration			P63563					X2BIT1,P63563					Rv1652		Rv1652			
NC_002945.3	Mycobrowser_v4	CDS	1852017	1853231	.	+	0	Mb1681	argJ		Probable Glutamate n-acetyltransferase argJ	Mb1681, argJ, len: 404 aa. Equivalent to Rv1653,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 404 aa overlap). Probable argJ,Glutamate n-acetyltransferase (EC 2.3.1.35), similar to ARGJ_BACSU|P36843 from Bacillus subtilis (406 aa), fasta scores: opt: 727, E(): 0, (36.3% identity in 410 a a overlap).	X2BIF9,P63572,P63572	No	intermediary metabolism and respiration			P63572					X2BIF9,P63572					Rv1653		Rv1653			
NC_002945.3	Mycobrowser_v4	CDS	1853228	1854112	.	+	0	Mb1682	argB		Probable Acetylglutamate kinase argB	Mb1682, argB, len: 294 aa. Equivalent to Rv1654,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 294 aa overlap). Probable argB,Acetylglutamate kinase (EC 2.7.2.8), similar to ARGB_CORGL|Q59281 (294 aa), FASTA scores: opt: 1209, E(): 0, (64.4% identity in 270 aa overlap). BELONGS TO THE ACETYLGLUTAMATE KINASE FAMILY.	X2BIX2,P0A4Y7,P0A4Y7	No	intermediary metabolism and respiration			P0A4Y7					X2BIX2,P0A4Y7					Rv1654		Rv1654			
NC_002945.3	Mycobrowser_v4	CDS	1854109	1855311	.	+	0	Mb1683	argD		Probable Acetylornithine aminotransferase argD	Mb1683, argD, len: 400 aa. Equivalent to Rv1655,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 400 aa overlap). Probable argD,Acetylornithine aminotransferase (EC 2.6.1.11), similar to ARGD_ECOLI|P18335 (406 aa), FASTA scores: opt: 958, E(): 0, (38.6% identity in 404 aa overlap), contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.	X2BIK4,P63569,P63569	No	intermediary metabolism and respiration			P63569					X2BIK4,P63569					Rv1655		Rv1655			
NC_002945.3	Mycobrowser_v4	CDS	1855308	1856231	.	+	0	Mb1684	argF		Probable Ornithine carbamoyltransferase,anabolic ArgF	Mb1684, argF, len: 307 aa. Equivalent to Rv1656,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Probable argF,ornithine carbamoyltransferase, anabolic (EC 2.1.3.3) (see citation below), almost identical to OTCA_MYCBO|Q02095 ornithine carbamoyltransferase, anabolic from Mycobacterium bovis (307 aa), FASTA scores: opt: 1980,E(): 0, (99.0% identity in 307 aa overlap); contains PS00097 Aspartate and ornithine carbamoyltransferases signature. BELONGS TO THE ATCASES/OTCASES FAMILY.	X2BI29,P0A5M9,P0A5M9	No	intermediary metabolism and respiration			P0A5M9					X2BI29,P0A5M9					Rv1656		Rv1656			
NC_002945.3	Mycobrowser_v4	CDS	1856228	1856740	.	+	0	Mb1685	argR		Probable Arginine repressor argR (AHRC)	Mb1685, argR, len: 170 aa. Equivalent to Rv1657,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 170 aa overlap). Probable argR, Arginine repressor (alternate gene name: ahrC). Similar to AHRC_BACSU|P17893 arginine hydroximate resistance protein from Bacillus subtilis (149 aa), FASTA scores: opt: 283,E(): 1.8e-11, (34.5% identity in 142 aa overlap); and ARGR_ECOLI|P15282 arginine repressor from Escherichia coli ( 156 aa), FASTA scores: opt: 194, E(): 6.4e-06, (30.8% identity in 146 aa overlap). BELONGS TO THE ARGR FAMILY.	X2BIT5,P0A4Y9,P0A4Y9	No	regulatory proteins			P0A4Y9					X2BIT5,P0A4Y9					Rv1657		Rv1657			
NC_002945.3	Mycobrowser_v4	CDS	1856749	1857945	.	+	0	Mb1686	argG		Probable Argininosuccinate synthase argG	Mb1686, argG, len: 398 aa. Equivalent to Rv1658,len: 398 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 398 aa overlap). Probable argG,Argininosuccinate synthase (EC 6.3.4.5), similar to ASSY_STRCL|P50986 argininosuccinate synthase from Streptomyces clavuligerus (397 aa), FASTA scores: opt: 1873, E(): 0, (67.8% identity in 397 aa overlap); contains PS00564 Argininosuccinate synthase signature 1, PS00565 Argininosuccinate synthase signature 2. BELONGS TO THE ARGININOSUCCINATE SYNTHASE FAMILY.	X2BIG1,P63643,P63643	No	intermediary metabolism and respiration			P63643					X2BIG1,P63643					Rv1658		Rv1658			
NC_002945.3	Mycobrowser_v4	CDS	1858025	1859437	.	+	0	Mb1687	argH		Probable Argininosuccinate lyase argH	Mb1687, argH, len: 470 aa. Equivalent to Rv1659,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 470 aa overlap). Probable argH,argininosuccinate lyase (EC 4.3.2.1), similar to ARLY_ECOLI|P11447 argininosuccinate lyase from Escherichia coli (457 aa), FASTA scores: opt: 1091, E(): 0, (42.5% identity in 461 aa overlap); contains PS00017 ATP/GTP-binding site motif A, PS00163 Fumarate lyases signature. BELONGS TO THE LYASE 1 FAMILY. ARGININOSUCCINATE LYASE SUBFAMILY.	X2BIX5,P0A4Z1,P0A4Z1	No	intermediary metabolism and respiration			P0A4Z1					X2BIX5,P0A4Z1					Rv1659		Rv1659			
NC_002945.3	Mycobrowser_v4	CDS	1859546	1860607	.	+	0	Mb1688	pks10		chalcone synthase pks10	Mb1688, pks10, len: 353 aa. Equivalent to Rv1660,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 353 aa overlap). Possible pks10,chalcone synthase (EC 2.3.1.74), similar to BCSA_BACSU|P54157 putative chalcone synthase from B. subtilis (365 aa), FASTA scores: opt: 701, E(): 0, (33.1% identity in 362 aa overlap). Also similar to M. tuberculosis Rv1665|pks11 polyketide synthase (chalcone synthase); and Rv1372|pks18 polyketide synthase. Other upstream initiation sites are possible but homology suggests this start.	X2BIL0,Q7VEV2,Q7VEV2	No				Q7VEV2					X2BIL0,Q7VEV2										
NC_002945.3	Mycobrowser_v4	CDS	1867090	1871898	.	+	0	Mb1690	pks8		Probable polyketide synthase pks8	Mb1690, pks8, len: 1602 aa. Equivalent to Rv1662,len: 1602 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1602 aa overlap). Probable pks8,polyketide synthase, similar to many polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa), FASTA scores: opt: 3319, E(): 0,(45.8% identity in 1619 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks12. Contains PS00606 Beta-ketoacyl synthases active site and PS01162 Quinone oxidoreductase/zeta-crystallin signature. Note that the similarity extends into the downstream ORF Rv1663 (MTCY275.02), and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found.	Q7VEV0,A0A1R3Y136	No				A0A1R3Y136				IPR001227,IPR002364,IPR011032,IPR013149,IPR013154,IPR014030,IPR014031,IPR014043,IPR015083,IPR016035,IPR016036,IPR016038,IPR016039,IPR016040,IPR018201,IPR020801,IPR020807,IPR020841,IPR020843	Q7VEV0										
NC_002945.3	Mycobrowser_v4	CDS	1890646	1891638	.	+	0	Mb1708	moeX		POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEX	Mb1708, moeX, len: 330 aa. Equivalent to Rv1681,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 330 aa overlap). Possible moeX,Molybdopterin biosynthesis protein, has weak similarity to MOAA_ECOLI|P30745 molybdenum cofactor biosynthesis protein (329 aa), FASTA scores: opt: 162, E(): 0.00081, (27.7% identity in 224 aa overlap) and to Rv3109|MTCY164.19 MoaA from Mycobacterium tuberculosis (28.5% identity in 165 aa overlap).	Q7TZS9,A0A1R3XYY9	No	intermediary metabolism and respiration			A0A1R3XYY9				IPR007197,IPR013785	Q7TZS9					Rv1681		Rv1681			
NC_002945.3	Mycobrowser_v4	CDS	1871898	1873406	.	+	0	Mb1691	pks17		Probable polyketide synthase pks17	Mb1691, pks17, len: 502 aa. Equivalent to Rv1663,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 502 aa overlap). Probable pks17,polyketide synthase, similar to other polyketide synthases e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa) from Saccharopolyspora erythraea (Streptomyces erythraeus), FASTA scores: opt: 1207, E(): 0, (43.9% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks1. Note that the similarity extends into the upstream ORF Rv1662 (MTCY275.01) and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found. Contains PS00012 Phosphopantetheine attachment site.	Q7VEU9,A0A1R3XZU8	No				A0A1R3XZU8				IPR002198,IPR006162,IPR009081,IPR016040,IPR020806,IPR020842	Q7VEU9										
NC_002945.3	Mycobrowser_v4	CDS	1873412	1876465	.	+	0	Mb1692	pks9		Probable polyketide synthase pks9	Mb1692, pks9, len: 1017 aa. Equivalent to Rv1664,len: 1017 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1017 aa overlap). Probable pks9,polyketide synthase, similar to OL56_STRAT|Q07017 oleandomycin polyketide synthase, modules 5 and 6 from Streptomyces antibioticus (3519 aa), FASTA scores: opt: 1767, E(): 0, (41.6% identity in 919 aa overlap). Similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks6, pks8, etc. Contains PS00012 Phosphopantetheine attachment site.	Q7VEU8,A0A1R3XYZ5	No				A0A1R3XYZ5				IPR001227,IPR006162,IPR009081,IPR014030,IPR014031,IPR014043,IPR016035,IPR016036,IPR016038,IPR016039,IPR020801,IPR020806	Q7VEU8										
NC_002945.3	Mycobrowser_v4	CDS	1876612	1877673	.	+	0	Mb1693	pks11		chalcone synthase pks11	Mb1693, pks11, len: 353 aa. Equivalent to Rv1665,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 353 aa overlap). Probable pks11,chalcone synthase (EC 2.3.1.74), some similarity to BCSA_BACSU|P54157 putative chalcone synthase from Bacillus subtilis (365 aa), FASTA scores: opt: 615, E(): 6.2e-32,(33.4% identity in 308 aa overlap); and to many plant chalcone synthases e.g. CHS_VIGUN|P51089 chalcone synthase (EC 2.3.1.74) (388 aa), FASTA scores: opt: 391, E(): 7.8e-18, (27.2% identity in 349 aa overlap). Highly similar to upstream ORF Rv1660|MTCY06H11.25 pks10 (72.7% identity in 308 aa overlap); and Rv1372 pks18.	X2BIL5,Q7VEU7,Q7VEU7	No				Q7VEU7					X2BIL5,Q7VEU7										
NC_002945.3	Mycobrowser_v4	CDS	1877656	1878948	.	-	0	Mb1694c	cyp139		Probable cytochrome P450 139 CYP139	Mb1694c, cyp139, len: 430 aa. Equivalent to Rv1666c, len: 430 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 430 aa overlap). Probable cyp139, cytochrome P450 (EC 1.14.-.-), similar to many e.g. U38537|APU38537_7 from Anabaena sp. (459 aa), FASTA scores: opt: 516, E(): 1.7e-26, (25.8% identity in 418 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.	X2BI36,P63720,P63720	No	intermediary metabolism and respiration			P63720					X2BI36,P63720					Rv1666c		Rv1666c			
NC_002945.3	Mycobrowser_v4	CDS	1888695	1889816	.	+	0	Mb1706	fadE16		POSSIBLE ACYL-COA DEHYDROGENASE FADE16	Mb1706, fadE16, len: 373 aa. Equivalent to Rv1679,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 373 aa overlap). Possible fadE16,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to acyl/butyryl-CoA dehydrogenases e.g. NP_244665.1|NC_002570 acyl-CoA dehydrogenase from Bacillus halodurans (380 aa); NP_000008.1|NM_000017 acyl-Coenzyme A dehydrogenase from Homo sapiens (412 aa); Z99113|BSUB0010_119 from Bacillus subtilis (380 aa), FASTA scores: opt: 439, E(): 3.4e-20,(29.6% identity in 287 aa overlap); etc. Weakly similar to many dehydrogenases and to P31571|CAIA_ECOLI probable carnitine operon oxidoreductase from Escherichia coli (380 aa), FASTA scores: opt: 109, E(): 0.0066, (28.6% identity in 98 aa overlap).	Q7TZT1,A0A1R3XZ09	No				A0A1R3XZ09				IPR006091,IPR009075,IPR009100,IPR013786	Q7TZT1										
NC_002945.3	Mycobrowser_v4	CDS	2922521	2922883	.	+	0	Mb2661	Mb2661		HYPOTHETICAL PROTEIN	Mb2661, -, len: 120 aa. Equivalent to Rv2628, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(98.3% identity in 120 aa overlap). Hypothetical unknown protein.	Q7TY70,A0A1R3Y1R8	No	conserved hypotheticals			A0A1R3Y1R8					Q7TY70					Rv2628		Rv2628			
NC_002945.3	Mycobrowser_v4	CDS	1887144	1887692	.	+	0	Mb1704	dsbF		PROBABLE CONSERVED LIPOPROTEIN DSBF	Mb1704, dsbF, len: 182 aa. Equivalent to Rv1677,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 182 aa overlap). Probable dsbF,conserved lipoprotein possibly involved in thiol:disulfide interchange. Highly similar to C-terminus of Z74024|MTCY274.09 mpt53 soluble secreted antigen precursor from Mycobacterium tuberculosis (173 aa), FASTA scores: opt: 482, E(): 3.6e-23, (52.8% identity in 142 aa overlap) . Also some similarity to P52237|TIPB_PSEFL THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR from Pseudomonas fluorescens (178 aa), FASTA scores: opt: 190,E(): 4.4e-05, (28.5% identity in 151 aa overlap); and P33926|DSBE_ECOLI THIOL:DISULFIDE INTERCHANGE PROTEIN from Escherichia coli (185 aa), FASTA scores: opt: 194, E(): 2.6e-05, (29.1% identity in 175 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00194 Thioredoxin family active site.	Q7TZT3,A0A1R3XZ07	No	cell wall and cell processes			A0A1R3XZ07				IPR012336,IPR013740,IPR017937	Q7TZT3					Rv1677		Rv1677			
NC_002945.3	Mycobrowser_v4	CDS	1898319	1898930	.	+	0	Mb1714	mpg		possible 3-methyladenine dna glycosylase mpg	Mb1714, -, len: 203 aa. Equivalent to Rv1688, len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 203 aa overlap). Possible 3-methyladenine DNA glycosylase (EC 3.2.2.-), similar to several eukaryotic 3-methylpurine DNA glycosylases and 3-methyladenine DNA glycosylases e.g. Q39147|X76169 3-METHYLADENINE GLYCOSYLASE from Arabidobsis thaliana (254 aa), FASTA scores: opt: 297, E(): 8.3e-15, (31.8% identity in 198 aa overlap) and P29372|3MG_HUMAN dna-3-methyladenine glycosidase (298 aa), FASTA scores: opt: 220, E(): 7.2e-05, (36.4% identity in 184 aa overlap). BELONGS TO THE MPG FAMILY OF DNA GLYCOSYLASES.	X2BIV6,P65413,P65413	No	information pathways			P65413					X2BIV6,P65413					Rv1688		Rv1688			
NC_002945.3	Mycobrowser_v4	CDS	1898942	1900216	.	+	0	Mb1715	tyrS		Probable Tyrosyl-tRNA synthase tyrS (TYRRS)	Mb1715, tyrS, len: 424 aa. Equivalent to Rv1689,len: 424 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 424 aa overlap). Probable tyrS,Tyrosyl-tRNA synthase (EC 6.1.1.1), highly similar to many e.g. SYY_ECOLI|P00951 Escherichia coli (EC 6.1.1.1) (423 aa), FASTA scores: opt: 1271, E(): 0, (47.3% identity in 419 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BII5,P67612,P67612	No	information pathways			P67612					X2BII5,P67612					Rv1689		Rv1689			
NC_002945.3	Mycobrowser_v4	CDS	1900833	1901252	.	+	0	Mb1716	lprJ		PROBABLE LIPOPROTEIN LPRJ	Mb1716, lprJ, len: 139 aa. Equivalent to Rv1690,len: 127 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 124 aa overlap). Probable lprJ,lipoprotein, contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Weakly similar to other Mycobacterium tuberculosis hypothetical proteins with conserved cysteines e.g. Rv1804c, Rv1810, Rv3354, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 2 bp insertion (*-ac) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (139 aa versus 127 aa).	Q7TZS4,A0A1R3XZ22	No	cell wall and cell processes			A0A1R3XZ22				IPR007969	Q7TZS4					Rv1690		Rv1690			
NC_002945.3	Mycobrowser_v4	CDS	1903282	1904088	.	+	0	Mb1720	tlyA		2'-o-methyltransferase tlya	Mb1720, tlyA, len: 268 aa. Equivalent to Rv1694,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 268 aa overlap). tlyA,cytotoxin/haemolysin homologue (see citations below),almost identical to NP_301968.1|NC_002677 cytotoxin/haemolysin homologue TlyA from Mycobacterium leprae (269 aa). TlyA homologues were also identified by PCR in M. avium, M. bovis BCG, but appeared absent in M. smegmatis, M. vaccae, M. kansasii, M. chelonae and M. phlei (see first citation below). Also highly similar to CAB83047.1|AJ271681 putative haemolysin from Mycobacterium ulcerans (281 aa); and similar to HLYA_TREHY|Q06803 pore-forming haemolysin/cytotoxin virulence determinant from Treponema hyodysenteriae (240 aa), FASTA scores: opt: 514, E():3e-30, (37.3% identity in 236 aa overlap).	Q7VEU4,A0A1R3XZV6	No	virulence, detoxification, adaptation			A0A1R3XZV6				IPR002877,IPR002942,IPR004538	Q7VEU4					Rv1694		Rv1694			
NC_002945.3	Mycobrowser_v4	CDS	1904088	1905011	.	+	0	Mb1721	ppnK		inorganic polyphosphate/atp-nad kinase ppnk (poly(p)/atp nad kinase)	Mb1721, ppnK, len: 307 aa. Equivalent to Rv1695,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 307 aa overlap). Probable ppnK,inorganic polyphosphate/ATP-NAD kinase (EC 2.7.1.23),equivalent to Q49897|MLC1351.13C|Z95117|PPNK_MYCLE INORGANIC POLYPHOSPHATE/ATP-NAD KINASE from Mycobacterium leprae (311 aa) (87.9% identity in 305 aa overlap). Also similar to many e.g. P37768|PPNK_ECOLI PROBABLE INORGANIC POLYPHOSPHATE/ATP-NAD KINASE (292 aa), FASTA scores: opt: 384, E(): 1.7e-23, (33.5% identity in 233 aa overlap); etc. BELONGS TO THE NAD KINASE FAMILY.	X2BIZ9,P0A5S7,P0A5S7	No	intermediary metabolism and respiration			P0A5S7					X2BIZ9,P0A5S7					Rv1695		Rv1695			
NC_002945.3	Mycobrowser_v4	CDS	1905025	1906788	.	+	0	Mb1722	recN		Probable DNA repair protein recN (Recombination protein N)	Mb1722, recN, len: 587 aa. Equivalent to Rv1696,len: 587 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 587 aa overlap). Probable recN, DNA repair protein, similar to many e.g. RECN_ECOLI|P05824 dna repair protein recN (553 aa), FASTA scores: opt: 508, E(): 1.9e-33, (31.5% identity in 587 aa overlap). Equivalent to Z95117|MLCB1351_12 recN from Mycobacterium leprae (587 aa), FASTA scores: (76.1% identit y in 589 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	X2BIP1,P0A5U7,P0A5U7	No	information pathways			P0A5U7					X2BIP1,P0A5U7					Rv1696		Rv1696			
NC_002945.3	Mycobrowser_v4	CDS	1908087	1909031	.	+	0	Mb1724	mctb		outer membrane protein mctb	Mb1724, -, len: 314 aa. Equivalent to Rv1698, len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 314 aa overlap). Conserved hypothetical protein, possibly exported protein with potential N-terminal signal sequence. Equivalent to Q49894|MLC1351.10C|Z95117 Hypothetical protein from Mycobacterium leprae (317 aa), FASTA scores: (77.0% identity in 317 aa overlap). Probable coiled-coil from aa 31 to 67.	X2BIW3,P64884,P64884	No	cell wall and cell processes			P64884					X2BIW3,P64884					Rv1698		Rv1698			
NC_002945.3	Mycobrowser_v4	CDS	1909171	1910931	.	+	0	Mb1725	pyrG		probable ctp synthase pyrg	Mb1725, pyrG, len: 586 aa. Equivalent to Rv1699,len: 586 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 586 aa overlap). pyrG, CTP synthase (EC 6.3.4.2) highly similar to many e.g. PYRG_ECOLI|P08398 ctp synthase from Escherichia coli (544 aa), FASTA scores: opt: 1786, E():0, (51.8% identity in 548 aa overlap). Contains PS00442 Glutamine amidotransferases class-I active site.	X2BIJ7,P0A5U3,P0A5U3	No	intermediary metabolism and respiration			P0A5U3					X2BIJ7,P0A5U3					Rv1699		Rv1699			
NC_002945.3	Mycobrowser_v4	CDS	1915127	1916797	.	-	0	Mb1730c	cycA		PROBABLE D-SERINE/ALANINE/GLYCINE TRANSPORTER PROTEIN CYCA	Mb1730c, cycA, len: 556 aa. Equivalent to Rv1704c,len: 556 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 556 aa overlap). Probable cycA,D-serine/D-alanine/glycine transporter, highly similar to P39312|CYCA_ECOLI d-serine/d-alanine/glycine transporter from Escherichia coli (470 aa), FASTA scores: opt: 1906,E(): 0, (59.3% identity in 459 aa overlap); etc. Also similar to other Mycobacterium tuberculosis amino-acid permeases e.g. Rv2127, Rv0346c, etc. Contains PS00218 amino acid permeases signature. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY).	Q7TZR8,A0A1R3XZW7	No				A0A1R3XZW7				IPR002293,IPR004840,IPR004841	Q7TZR8										
NC_002945.3	Mycobrowser_v4	CDS	1916838	1917995	.	-	0	Mb1731c	PPE22		ppe family protein ppe22	Mb1731c, PPE22, len: 385 aa. Equivalent to Rv1705c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 385 aa overlap). Member of the M. tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kd protein cy274.2 3 (404 aa), fasta scores: opt: 819, E(): 0, (46.2% identity in 413 aa overlap).	Q7TZR7,A0A1R3XZ34	No				A0A1R3XZ34				IPR000030,IPR022171	Q7TZR7										
NC_002945.3	Mycobrowser_v4	CDS	1918035	1919219	.	-	0	Mb1732c	PPE23		ppe family protein ppe23	Mb1732c, PPE23, len: 394 aa. Equivalent to Rv1706c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 394 aa overlap). Member of the M. tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kd protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap).	Q7TZR6,A0A1R3XZG1	No				A0A1R3XZG1				IPR000030,IPR022171	Q7TZR6										
NC_002945.3	Mycobrowser_v4	CDS	1928000	1928563	.	+	0	Mb1742	fadB3a		PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FADB3a [FIRST PART] (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) (BHBD)	Mb1742, fadB3a, len: 187 aa. Equivalent to the 5' end of Rv1715, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 187 aa overlap). Probable fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa); P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b.	Q7TZR0,A0A1R3XZG8	No				A0A1R3XZG8				IPR006176,IPR016040	Q7TZR0										
NC_002945.3	Mycobrowser_v4	CDS	1922654	1923490	.	+	0	Mb1736	scpa		possible segregation and condensation protein scpa	Mb1736, -, len: 278 aa. Equivalent to Rv1709, len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 278 aa overlap). Conserved hypothetical protein, similar to others e.g. P35154|YPUG_BACSU from Bacillus subtilis (251 aa), FASTA scores: opt: 271, E(): 8.2e-10, (27.0% identity in 248 aa overlap); Q9S230|SCI51.10C|AL109848 from Streptomyces coelicolor (264 aa), FASTA scores: opt: 855, E(): 0, (56.8% identity in 257 aa overlap). Equivalent to Q49888|MLC1351.05C|Z95117 from Mycobacterium leprae (268 aa), FASTA scores: (78.9% identity in 251 aa overlap).	Q7TZR2,A0A1R3XZ42	No	cell wall and cell processes			A0A1R3XZ42				IPR003768	Q7TZR2					Rv1709		Rv1709			
NC_002945.3	Mycobrowser_v4	CDS	1923487	1924182	.	+	0	Mb1737	scpb		possible segregation and condensation protein scpb	Mb1737, -, len: 231 aa. Equivalent to Rv1710, len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 231 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins e.g. P35155|YPUH_BACSU from Bacillus subtilis (197 aa), FASTA scores: opt: 339, E(): 1.3e-09, (36.0% identity in 186 aa overlap); Q9S231|SCI51.09C|AL109848 from Streptomyces coelicolor (223 aa), FASTA scores: opt: 626, E(): 0,(51.0% identity in 192 aa overlap). Equivalent to O05669|MLC1351.04C|Z95117 Hypothetical protein from Mycobacterium leprae (231 aa), FASTA scores: (77.9% identity in 231 aa overlap).	Q7TZR1,A0A1R3XZ21	No	cell wall and cell processes			A0A1R3XZ21				IPR005234,IPR011991	Q7TZR1					Rv1710		Rv1710			
NC_002945.3	Mycobrowser_v4	CDS	1924940	1925632	.	+	0	Mb1739	cmk		cytidylate kinase cmk (cmp kinase) (cytidine monophosphate kinase) (ck)	Mb1739, cmk, len: 230 aa. Equivalent to Rv1712,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 230 aa overlap). Probable cmk,cytidylate kinase (EC 2.7.4.14), highly similar to many e.g. KCY_ECOLI|P23863 cytidylate kinase from Escherichia coli (227 aa), FASTA scores: opt: 534, E (): 0, (40.3% identity in 221 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Equivalent to Z95117|MLCB1351_2 from Mycobacterium leprae (223 aa) (73.5% identity in 226 aa overlap). BELONGS TO THE CYTIDYLATE KINASE FAMILY, SUBFAMILY 1.	X2BIX3,P63804,P63804	No	intermediary metabolism and respiration			P63804					X2BIX3,P63804					Rv1712		Rv1712			
NC_002945.3	Mycobrowser_v4	CDS	1925629	1927020	.	+	0	Mb1740	engA		PROBABLE GTP-BINDING PROTEIN ENGA	Mb1740, engA, len: 463 aa. Equivalent to Rv1713,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 463 aa overlap). Probable engA,GTP-binding protein. Equivalent to Q49884|MLCB1351.01|U00021_5 PROBABLE GTP-BINDING PROTEIN ENGA from Mycobacterium leprae (461 aa), (88.6% identity in 463 aa overlap). And similar to many e.g. P50743|ENGA_BACSU PROBABLE GTP-BINDING PROTEIN ENGA from Bacillus subtilus (436 aa), FASTA scores: opt: 1077, E(): 0, (40.6% identity in 434 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ERA/TRME FAMILY OF GTP-BINDING PROTEINS. ENGA SUBFAMILY.	X2BIL4,P64058,P64058	No	intermediary metabolism and respiration			P64058					X2BIL4,P64058					Rv1713		Rv1713			
NC_002945.3	Mycobrowser_v4	CDS	1928621	1928914	.	+	0	Mb1743	fadB3b		PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FADB3b [SECOND PART] (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) (BHBD)	Mb1743, fadB3b, len: 97 aa. Equivalent to the 3' end of Rv1715, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 97 aa overlap). Probable fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa); P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b.	Q7TZQ9,A0A1R3XZ49	No				A0A1R3XZ49				IPR006108,IPR008927,IPR013328	Q7TZQ9										
NC_002945.3	Mycobrowser_v4	CDS	2195608	2195859	.	-	0	Mb1995c	pard1		possible antitoxin pard1	Mb1995c, -, len: 83 aa. Equivalent to Rv1960c, len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Conserved hypothetical protein, similar to O85269|AF102990|AF102990_51 hypothetical protein of Yersinia enterocolitica (80 aa),FASTA scores: opt: 149, E(): 0.00037, (42 .1% identity in 57 aa overlap).	X2BJG7,P67299,P67299	No	virulence, detoxification, adaptation			P67299					X2BJG7,P67299					Rv1960c		Rv1960c			
NC_002945.3	Mycobrowser_v4	CDS	2976836	2977093	.	-	0	Mb2725c	Mb2725c		HYPOTHETICAL PROTEIN	Mb2725c, -, len: 85 aa. Equivalent to Rv2706c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Hypothetical unknown protein.	Q7TY24,A0A1R3Y1X8	No	conserved hypotheticals			A0A1R3Y1X8					Q7TY24					Rv2706c		Rv2706c			
NC_002945.3	Mycobrowser_v4	CDS	1943074	1944630	.	+	0	Mb1760	gabD2		possible succinate-semialdehyde dehydrogenase [nadp+] dependent (ssdh) gabd2	Mb1760, gabD2, len: 518 aa. Equivalent to Rv1731,len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 518 aa overlap). Possible gabD2,succinate-semialdehyde dehydrogenase [NADP+] dependent (EC 1.2.1.16), similar to others e.g. GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from Escherichia coli (482 aa), FASTA scores: opt: 870, E(): 0, (34.7% identity in 449 aa overlap); etc. Also similar to gabD1|Rv0234c|MTCY08D5.30c PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDANT from Mycobacterium tuberculosis (511 aa); and other semialdehyde dehydrogenases e.g. Rv0768|aldA (489 aa), Rv2858c|aldC (455 aa), etc. Contains PS00216 Sugar transport proteins signature 1, PS00687 Aldehyde dehydrogenases glutamic acid active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Note that previously known as gabD1.	X2BIY8,Q7TZP3,Q7TZP3	No				Q7TZP3					X2BIY8,Q7TZP3										
NC_002945.3	Mycobrowser_v4	CDS	1947625	1949583	.	-	0	Mb1765c	narX		Probable nitrate reductase NarX	Mb1765c, narX, len: 652 aa. Equivalent to Rv1736c,len: 652 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 652 aa overlap). Probable narX, nitrate reductase (EC 1.7.99.4). Contains three domains: N-terminus (250 aa) is similar to e.g. N-terminus of NARG_ECOLI|P09152 respiratory nitrate reductase 1 alpha chain from Escherichia coli (1246 aa), FASTA scores: E(): 0, (58.6% identity in 251 aa overlap); and Rv1161|MTCI65.28|NARG PROBABLE RESPIRATORY NITRATE REDUCTASE (ALPHA CHAIN) from Mycobacterium tuberculosis (1232 aa). Central region (260-410 aa) is similar to Rv1163|O06561|NARJ PROBABLE RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) from Mycobacterium tuberculosis (201 aa),FASTA scores: E(): 0, (64.2% identity in 159 aa overlap). C-terminus (420 aa-) is similar to Rv1164|O06562|NARI PROBABLE RESPIRATORY NITRATE REDUCTASE (GAMMA CHAIN) from M. tuberculosis (246 aa), FASTA scores: E(): 0, (68.6% identity in 239 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.	Q7VEU1,A0A1R3XZ78	No				A0A1R3XZ78				IPR003765,IPR003816,IPR006656,IPR006963,IPR020945,IPR023234,IPR027467	Q7VEU1										
NC_002945.3	Mycobrowser_v4	CDS	1949580	1950767	.	-	0	Mb1766c	narK2		POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2	Mb1766c, narK2, len: 395 aa. Equivalent to Rv1737c,len: 395 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 395 aa overlap). Possible narK2,nitrate/nitrite-transport integral membrane protein (see first citation below), possibly member of major facilitator superfamily (MFS), similar to P46907|NARK_BACSU nitrite extrusion protein from Bacillus subtilis (395 aa), FASTA scores: opt: 742, E(): 0, (33.6% identity in 375 aa overlap); and to AL109989|SCJ12.23 hypothetical nitrate/nitrite transporter from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1181, E(): 0,(49.4% identity in 389 aa overlap).	Q7TZN8,A0A1R3XZ73	No				A0A1R3XZ73				IPR011701,IPR016196,IPR020846	Q7TZN8										
NC_002945.3	Mycobrowser_v4	CDS	1954402	1956102	.	+	0	Mb1772	pknE		PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE E PKNE (PROTEIN KINASE E) (STPK E)	Mb1772, pknE, len: 566 aa. Equivalent to Rv1743,len: 566 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 566 aa overlap). Probable pknE,transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citation below), similar to PKN1_MYXXA|P33973 serine/threonine-protein kinase pkn1 (693 aa), fasta scores: opt: 542, E(): 1.1e-19, (35.8% identity in 302 aa overlap). Also highly similar to K08G_MYCTU|Q11053 probable serine/threonine-protein kinase (626 aa) (59.8% identity in 381 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.	X2BJ35,Q7TZN3,Q7TZN3	No	regulatory proteins			Q7TZN3					X2BJ35,Q7TZN3					Rv1743		Rv1743			
NC_002945.3	Mycobrowser_v4	CDS	1956859	1957389	.	-	0	Mb1774c	idi		Probable isopentenyl-diphosphate delta-isomerase IDI (IPP isomerase) (Isopentenyl pyrophosphate isomerase)	Mb1774c, idi, len: 176 aa. Equivalent to Rv1745c,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 176 aa overlap). Probable idi,isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2),similar to Q46822|ORF_O182 from Escherichia coli (182 aa),FASTA scores: opt: 465, E(): 4.7e-25, (46.9% identity in 162 aa overlap), and to IPPI_SCHPO|Q10132 isopentenyl-diphosphate delta-isomerase from Schizosaccharomyces pombe (227 aa), FASTA scores: opt: 185, E(): 5.4e-06, (30.3% identity in 152 aa overlap). BELONGS TO THE IPP ISOMERASE TYPE 1 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 3' end due to a single base tranversion (g-t), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (176 aa versus 203 aa).	X2BIB8,Q7VEU0,Q7VEU0	No				Q7VEU0					X2BIB8,Q7VEU0										
NC_002945.3	Mycobrowser_v4	CDS	1957536	1958966	.	+	0	Mb1775	pknF		ANCHORED-MEMBRANE SERINE/THREONINE-PROTEIN KINASE PKNF (PROTEIN KINASE F) (STPK F)	Mb1775, pknF, len: 476 aa. Equivalent to Rv1746,len: 476 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 476 aa overlap). pknF, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to KY28_MYCTU|Q10697 probable serine/threonine-protein kinase from Mycobacterium tuberculosis (589 aa), FASTA scores: opt: 870, E(): 0, (41.6% identity in 406 aa overlap). Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. Start site chosen by homology, may extend further upstream.	X2BJ00,Q7TZN1,Q7TZN1	No	regulatory proteins			Q7TZN1					X2BJ00,Q7TZN1					Rv1746		Rv1746			
NC_002945.3	Mycobrowser_v4	CDS	1963367	1964965	.	-	0	Mb1779c	fadD1		POSSIBLE FATTY-ACID-COA LIGASE FADD1 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb1779c, fadD1, len: 532 aa. Equivalent to Rv1750c,len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 532 aa overlap). Possible fadD1,fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to others e.g. O35488|VLCS_MOUSE VERY-LONG-CHAIN ACYL-COA SYNTHETASE from Mus musculus (620 aa); NP_113924.1|NM_031736 solute carrier family 27 (fatty acid transporter) member 2 from Rattus norvegicus (620 aa); NP_459076.1|NC_003197 crotonobetaine/carnitine-CoA ligase from Salmonella typhimurium (517 aa); CAIC_ECOLI|P31552 probable crotonobetaine/carnitine-coa ligase from Escherichia coli (522 aa), FASTA scores: opt: 448, E(): 1.9e-21, (25.1% identity in 502 aa overlap); etc. Also highly similar to fadD17|Rv3506|MTV023.13 PROBABLE FATTY-ACID-COA LIGASE from Mycobacterium tuberculosis (502 aa); and similar to others from Mycobacterium tuberculosis e.g. fadD6|MTCI364.18|Rv1206|O05307 PROBABLE FATTY-ACID-COA LIGASE (597 aa), FASTA score: (28.3% identity in 519 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7TZM7,A0A1R3XZ72	No				A0A1R3XZ72				IPR000873,IPR020845,IPR025110	Q7TZM7										
NC_002945.3	Mycobrowser_v4	CDS	1980674	1983136	.	-	0	Mb1789c	wag22b		PE-PGRS FAMILY PROTEIN WAG22B [SECOND PART]	Mb1789c, wag22b, len: 820 aa. Equivalent to 3' end of Rv1759c, len: 914 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 820 aa overlap). wag22,antigen member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kd protein from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 2010, E(): 0,(53.0% identity in 724 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b.	X2BID9,P0A687	No				P0A687					X2BID9										
NC_002945.3	Mycobrowser_v4	CDS	1967012	1970167	.	-	0	Mb1782c	PPE24		ppe family protein ppe24	Mb1782c, PPE24, len: 1051 aa. Similar to Rv1753c,len: 1053 aa, from Mycobacterium tuberculosis strain H37Rv, (90.7% identity in 1103 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Asn-rich proteins, similar to many e.g. YF48_MYCTU|Q10778 hypothetical protein cy48.17 (678 aa), FASTA scores: opt: 1360, E(): 0, (48.9% identity in 550 aa overlap). Note that the Gly-, Asn-rich sequence is interrupted by six near-perfect 26 aa repeats, a unique region, and another,more degenerate region of five 25 aa repeats before resuming at the C-terminus. The end of the first Gly-,Asn-rich region and the start of the first set of repeats shows some similarity to Q50577|AT10S from Mycobacterium tuberculosis (170 aa) (40.2% identity in 189 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 150 bp insertion and a 156 bp deletion, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1051 aa versus 1053 aa).	Q7TZM4,A0A1R3XZ91	No				A0A1R3XZ91				IPR000030,IPR002989	Q7TZM4										
NC_002945.3	Mycobrowser_v4	CDS	2013905	2015086	.	-	0	Mb1813c	cyp143		PROBABLE CYTOCHROME P450 143 CYP143	Mb1813c, cyp143, len: 393 aa. Equivalent to Rv1785c, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 393 aa overlap). Probable cyp143, cytochrome P450 (1.14.-.-), similar to many e.g. AE0001|RZAE000101_4 Rhizobium sp. NGR234 (414 aa), FASTA scores: opt: 663, E(): 0, (32.4% identity in 413 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.	X2BIG2,P63724,P63724	No	intermediary metabolism and respiration			P63724					X2BIG2,P63724					Rv1785c		Rv1785c			
NC_002945.3	Mycobrowser_v4	CDS	1972246	1973790	.	-	0	Mb1784c	plcD		PROBABLE PHOSPHOLIPASE C 4 PLCD	Mb1784c, plcD, len: 514 aa. Equivalent to MT1799,len: 514 aa, from Mycobacterium tuberculosis strain CDC1551, (100% identity in 514 aa overlap). Probable plcD,phospholipase C 4 (EC 3.1.4.3) (see citation below),highly similar to other phospholipases e.g. Q04001|PHLA_MYCTU|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA from Mycobacterium tuberculosis (512 aa), FASTA score: opt: 2657, E(): 4.9e-156, (71.1% identity in 512 aa overlap); P95246|PHLB_MYCTU|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB from Mycobacterium tuberculosis (512 aa), FASTA score: opt: 2638, E(): 7.3e-155, (70.9% identity in 512 aa overlap); etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 region.	X2BID1,P0A5R9,P0A5R9	No				P0A5R9					X2BID1,P0A5R9										
NC_002945.3	Mycobrowser_v4	CDS	2216544	2216900	.	-	0	Mb2017c	cmtr		metal sensor transcriptional regulator cmtr (arsr-smtb family)	Mb2017c, -, len: 118 aa. Equivalent to Rv1994c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 118 aa overlap). Probable transcription regulator, similar to MERR_STRLI|P30346 probable mercury resistance operon repressor (125 aa),FASTA scores: opt: 199, E(): 3e-08, (36.3% identity in 102 aa overlap). Contains probable helix-turn-helix motif at aa 36-57 (+3.78 SD).	X2BJI3,P67732,P67732	No	regulatory proteins			P67732					X2BJI3,P67732					Rv1994c		Rv1994c			
NC_002945.3	Mycobrowser_v4	CDS	1976593	1979430	.	+	0	Mb1787	mmpL14		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL14	Mb1787, mmpL14, len: 945 aa. Equivalent to MT1802 (also known as RVD2-ORF3), len: 945 aa, from Mycobacterium tuberculosis strain CDC1551, (99.7% identity in 945 aa overlap). Probable mmpL14, conserved transmembrane transport protein (see citation below). Member of RND superfamily, similar to several putative transport proteins e.g. O53784|MML5_MYCTU|MMPL5|Rv0676c|MT0705|MTV040.04c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (964 aa), FASTA scores: opt: 1171, E(): 2.5e-61, (32.10% identity in 947 aa overlap); P95211|MML1_MYCTU|MMPL1|Rv0402c|MT0412|MTCY04D9.15c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (958 aa), FASTA scores: opt: 1170, E(): 2.8e-61, (33.1% identity in 940 aa overlap); etc. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 region.	Q7TZM0,A0A1R3XZ87	No				A0A1R3XZ87				IPR004707,IPR004869	Q7TZM0										
NC_002945.3	Mycobrowser_v4	CDS	1979751	1980407	.	+	0	Mb1788	cut1		PROBABLE CUTINASE CUT1	Mb1788, -, len: 218 aa. Similar to Rv1758, len: 174 aa, from Mycobacterium tuberculosis strain H37Rv, (98.25% identity in 172 aa overlap). Probable cut1, serine esterase, cutinase family (EC 3.1.1.-), similar to Rv2301|CUT2_MYCTU|Q50664 probable cutinase cy339.08c precursor from Mycobacterium tuberculosis (219 aa), FASTA scores: opt: 369, E(): 1. 1e-16, (39.1% identity in 179 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical cutinases Rv3452, Rv1984c, Rv3451 and Rv3724. CDS has been interrupted by IS6110 insertion element and 5'-end deleted. BELONGS TO THE CUTINASE FAMILY. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted.	Q7TZL9,A0A1R3XZ70	No				A0A1R3XZ70				IPR000675	Q7TZL9										
NC_002945.3	Mycobrowser_v4	CDS	1983133	1983417	.	-	0	Mb1790c	wag22a		PE-PGRS FAMILY PROTEIN WAG22A [FIRST PART]	Mb1790c, wag22a, len: 94 aa. Equivalent to 5' end of Rv1759c, len: 914 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 84 aa overlap). wag22,antigen member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kd protein from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 2010, E(): 0,(53.0% identity in 724 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b.	Q7TZL8,P0A687	No				P0A687				IPR000084	Q7TZL8										
NC_002945.3	Mycobrowser_v4	CDS	1991054	1992928	.	+	0	Mb1797	PE_PGRS31		pe-pgrs family protein pe_pgrs31	Mb1797, PE_PGRS31, len: 624 aa. Equivalent to Rv1768, len: 618 aa, from Mycobacterium tuberculosis strain H37Rv, (98.88% identity in 624 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to Q50615 HYPOTHETICAL 40.8 KD PROTEIN (498 aa), FASTA scores: opt: 1703, E(): 0, (57.4% identity in 566 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 18 bp insertion, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (624 aa versus 618 aa).	Q7TZL0,A0A1R3XZ75	No				A0A1R3XZ75				IPR000084	Q7TZL0										
NC_002945.3	Mycobrowser_v4	CDS	2001114	2002418	.	+	0	Mb1806	cyp144		Probable cytochrome p450 144 CYP144	Mb1806, cyp144, len: 434 aa. Equivalent to Rv1777,len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 434 aa overlap). Probable cyp144,cytochrome p450 (EC 1.14.-.-), similar to CPXM_BACME|Q06069 cytochrome p450 (meg) (EC 1.14.99.-) (410 aa), FASTA scores: opt: 435 E(): 2.3e-16, (28.8% identity in 372 aa overlap). Also similar to several other Mycobacterium tuberculosis p450 genes including Rv0766c,Rv2266, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.	Q7VET9,A0A1R3XZA3	No				A0A1R3XZA3				IPR001128,IPR002397,IPR017972	Q7VET9										
NC_002945.3	Mycobrowser_v4	CDS	2005760	2007934	.	-	0	Mb1810c	malQ		PROBABLE 4-ALPHA-GLUCANOTRANSFERASE MALQ (Amylomaltase) (Disproportionating enzyme) (D-enzyme)	Mb1810c, malQ, len: 724 aa. Equivalent to Rv1781c,len: 724 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 724 aa overlap). Probable malQ,4-ALPHA-GLUCANOTRANSFERASE (EC 2.4.1.25), similar to many,e.g. P15977|MALQ_ECOLI 4-ALPHA-GLUCANOTRANSFERASE (694 aa), FASTA scores: opt: 964, E(): 0, (31.8% identity in 694 aa overlap). BELONGS TO THE DISPROPORTIONATING ENZYME FAMILY.	X2BIU5,P65337,P65337	No				P65337					X2BIU5,P65337										
NC_002945.3	Mycobrowser_v4	CDS	2008198	2009718	.	+	0	Mb1811	eccb5		esx conserved component eccb5. esx-5 type vii secretion system protein. probable membrane protein.	Mb1811, -, len: 506 aa. Equivalent to Rv1782, len: 506 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 506 aa overlap). Probable conserved membrane protein, similar to four other Mycobacterium tuberculosis hypothetical membrane proteins e.g. O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa), FASTA scores: opt: 1106, E(): 0, (41.2% identity in 485 aa overlap); Rv0283, Rv3450c, and Rv3869, all located near ESAT-6 family genes. Also similar to O33088|MLCB628.17C|Y14967 cosmid B628 from Mycobacterium leprae (481 aa), (32.7% identity in 486 aa overlap); and equivalent to Q9Z5I3|MLCB596.27|AL035472 hypothetical protein from Mycobacterium leprae (506 aa) (82.6% identity in 506 aa overlap). Has hydrophobic stretch from aa 54-76.	Q7TZJ8,A0A1R3XZC8	No	cell wall and cell processes			A0A1R3XZC8				IPR007795	Q7TZJ8					Rv1782		Rv1782			
NC_002945.3	Mycobrowser_v4	CDS	2009715	2013890	.	+	0	Mb1812	eccc5		esx conserved component eccc5. esx-5 type vii secretion system protein.	Mb1812, -, len: 1391 aa. Similar to Rv1783 and Rv1784, len: 435 aa and 932 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 435 aa overlap and 99.9% identity in 932 aa overlap). Rv1783: Probable conserved membrane protein. Member of family of Mycobacterium tuberculosis hypothetical proteins including O05450|Rv3894c|MTY15F10.18|Z94121 (1396 aa), FASTA scores: opt: 542, E(): 1.5e-26, (31.4% identity in 440 aa overlap); Rv3447c, Rv0284, Rv3870, Rv1784, and Rv3871, all linked to ESAT-6 family gene. Similar to N-terminal part of Rv3894c (1396 aa), Rv1784 is similar to remainder of Rv3894c. Also similar to O33087|MLCB628.16C|Y14967 Hypothetical protein from Mycobacterium leprae (744 aa),(30.0% identity in 437 aa overlap) and equivalent to N-terminal part of Q9Z5I2|MLCB596.28|AL035472 hypothetical protein from Mycobacterium leprae (1345 aa), (86.4% identity in 397 aa overlap). Rv1784: Conserved hypothetical protein, member of family of Mycobacterium tuberculosis hypothetical proteins including Rv3447c,Rv0284, Rv3870, Rv1783, Rv3871, Rv3894c, all linked to ESAT-6 family genes. Probably ATP-binding membrane proteins. Similar to C-terminal region of 006264|Rv3447c (1236 aa), (36.2% identity in 930 aa overlap). Equivalent to C-terminal region of Mycobacterium leprae hypothetical protein Q9Z512|MLCB596.28|AL035472 (1345 aa), (87.8% identity in 932 aa overlap); also similar to other hypothetical proteins e.g. MLCB628.14 from Mycobacterium leprae, (32.0% identity in 600 aa overlap); MLCB628.15 from Mycobacterium leprae, (35.0% identity in 280 aa overlap); and O86653|SC3C3.20|AL031231 ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 618, E(): 4.6e-30, (34.3% identity in 937 aa overlap). Contains two times PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis, a single base transversion (a-t) leads to a single product.	Q7TZJ7,A0A1R3XZN3	No				A0A1R3XZN3				IPR002543,IPR003593,IPR023836,IPR023837,IPR027417	Q7TZJ7										
NC_002945.3	Mycobrowser_v4	CDS	2015759	2016853	.	+	0	Mb1815	PPE25		ppe family protein ppe25	Mb1815, PPE25, len: 364 aa. Equivalent to Rv1787,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 365 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FASTA scores: opt: 837, E(): 0, (52.0% identity in 406 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 8 bp to 5 bp substitution (agcccggt-ccggg), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa).	Q7TZJ5,A0A1R3XZC3	No				A0A1R3XZC3				IPR000030,IPR022171	Q7TZJ5										
NC_002945.3	Mycobrowser_v4	CDS	2017245	2018426	.	+	0	Mb1817	PPE26		ppe family protein ppe26	Mb1817, PPE26, len: 393 aa. Equivalent to Rv1789,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 393 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to others e.g.Z98268|MTCI125.26 Mycobacterium tuberculosis cosmid (385 aa), FASTA score: opt: 1283, E(): 0, (62.7% identity in 408 aa overlap).	Q7TZJ3,A0A1R3XZ96	No				A0A1R3XZ96				IPR000030,IPR022171	Q7TZJ3										
NC_002945.3	Mycobrowser_v4	CDS	2018880	2019932	.	+	0	Mb1818	PPE27		ppe family protein ppe27	Mb1818, PPE27, len: 350 aa. Equivalent to Rv1790,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 350 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich protein, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FASTA scores: opt: 849, E(): 0, (50.0% identity in 406 aa overlap).	Q7TZJ2,A0A1R3XZB1	No				A0A1R3XZB1				IPR000030,IPR022171	Q7TZJ2										
NC_002945.3	Mycobrowser_v4	CDS	2020359	2020658	.	+	0	Mb1819	PE19		pe family protein pe19	Mb1819, PE19, len: 99 aa. Equivalent to Rv1791,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family, but no glycine rich C-terminus, highly similar to Z93777|MTCI364.07 M.tuberculosis cosmid (99 aa) opt: 430 E(): 2.4e-21,(75.5% identity in 98 aa overlap).	Q7TZJ1,A0A1R3Y1H4	No	PE/PPE			A0A1R3Y1H4				IPR000084	Q7TZJ1					Rv1791		Rv1791			
NC_002945.3	Mycobrowser_v4	CDS	2020802	2021098	.	+	0	Mb1820	esxM		esat-6 like protein esxm	Mb1820, esxM, len: 98 aa. Equivalent to Rv1792,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(98.0% identity in 98 aa overlap). esxM, conserved hypothetical protein, member of Mycobacterium tuberculosis QILSS familyof proteins, genes linked to those of ESAT-6 family. Has in-frame stop codon at 18074, no error could be found to account for this. Identical (apart from stop codon) to P96363|Rv1038c|MTCY10G2.11 PUTATIVE ESAT-6 LIKE PROTEIN 2 (98 aa), FASTA scores: opt: 389, E(): 5.8e-26,(100.0% identity in 58 aa overlap). Also identical to Rv1038c, Rv1197, and almost identical to Rv3620c and Rv2347c. Similar protein present in Mycobacterium leprae e.g. Q49946|MLCB1701.06C|AL049191 PUTATIVE ESAT-6 LIKE PROTEIN X (95 aa), FASTA scores: opt: 343, E(): 1.6e-17,(57.6% identity in 92 aa overlap).	X2BIW1,P59805	No	cell wall and cell processes			P59805					X2BIW1					Rv1792		Rv1792			
NC_002945.3	Mycobrowser_v4	CDS	2021149	2021433	.	+	0	Mb1821	esxN		putative esat-6 like protein esxn (esat-6 like protein 5)	Mb1821, esxN, len: 94 aa. Equivalent to Rv1793,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). esxN, putative ESAT-6 like protein, conserved hypothetical protein, almost identical to several hypothetical mycobacterial proteins of the ESAT-6-like family including P95242|Rv2346c|MTCY98.15C|Z83860 PUTATIVE ESAT-6 LIKE PROTEIN 6 (94 aa), FASTA scores: opt: 610, E(): 0, (97.9 % identity in 94 aa overlap); Rv3619c, Rv1037c, and Rv1198,etc. Also present in Mycobacterium leprae.	X2BJ78,P0A571	No	cell wall and cell processes			P0A571					X2BJ78					Rv1793		Rv1793			
NC_002945.3	Mycobrowser_v4	CDS	2032456	2033727	.	+	0	Mb1829	PPE29		ppe family protein ppe29	Mb1829, PPE29, len: 423 aa. Equivalent to Rv1801,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 423 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to AL022021|MTV049.29|Rv1808 (409 aa), FASTA scores: opt: 1229, E(): 0, (55.2% identity in 422 aa overlap). TBparse score is 0.927.	Q7TZI4,A0A1R3Y1I6	No				A0A1R3Y1I6				IPR000030,IPR022171	Q7TZI4										
NC_002945.3	Mycobrowser_v4	CDS	2033839	2035230	.	+	0	Mb1830	PPE30		ppe family protein ppe30	Mb1830, PPE30, len: 463 aa. Equivalent to Rv1802,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to AL022021|MTV049.30|Rv1809 (468 aa), FASTA scores: opt: 1238, E(): 0, (51.0% identity in 471 aa overlap).	X2BIX6,P0A693	No				P0A693					X2BIX6										
NC_002945.3	Mycobrowser_v4	CDS	2022695	2024206	.	+	0	Mb1823	eccd5		esx conserved component eccd5. esx-5 type vii secretion system protein. probable membrane protein.	Mb1823, -, len: 503 aa. Equivalent to Rv1795, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 503 aa overlap). Conserved hypothetical membrane protein, has a hydrophilic stretch from ~1-130 then very hydrophobic. Similar to several other mycobacterial proteins, all linked to ESAT-6 family e.g. Rv3887c|MTY15F10.24|Z94121 (509 aa), FASTA scores: opt: 360, E(): 1.6e-15, (26.7% identity in 514 aa overlap); Rv3448, and Rv0290.	Q7TZI9,A0A1R3XZC1	No	cell wall and cell processes			A0A1R3XZC1				IPR006707,IPR024962	Q7TZI9					Rv1795		Rv1795			
NC_002945.3	Mycobrowser_v4	CDS	2024184	2025941	.	+	0	Mb1824	mycp5		probable proline rich membrane-anchored mycosin mycp5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	Mb1824, -, len: 585 aa. Equivalent to Rv1796, len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 585 aa overlap). Conserved hypothetical Pro-rich protease. Member of family with four other Mycobacterium tuberculosis hypothetical proteases including Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa),FASTA scores: opt: 1173, E(): 0, (47.9% identity in 578 aa overlap); Rv0291, Rv3883c, and Rv3449. Genes all linked to those of ESAT-6 family. Has possible N-terminal signal peptide and hydrophobic anchor-like stretch at C-terminus. Contains two serine protease, subtilase family active site motifs: a aspartic acid active site motif (PS00136); and a histidine active site motif (PS00137).	Q7TZI8,A0A1R3XZD8	No	intermediary metabolism and respiration			A0A1R3XZD8				IPR000209,IPR015500,IPR023827,IPR023834	Q7TZI8					Rv1796		Rv1796			
NC_002945.3	Mycobrowser_v4	CDS	2025938	2027158	.	+	0	Mb1825	ecce5		esx conserved component ecce5. esx-5 type vii secretion system protein. probable membrane protein.	Mb1825, -, len: 406 aa. Equivalent to Rv1797, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Conserved hypothetical protein, some similarity to Mycobacterium tuberculosis O05462|Rv3882c|MTCY15F10.30|Z94121 (462 aa),FASTA scores: opt: 181, E(): 9.2e-05, (25.4% identity in 283 aa overlap). Has hydrophobic stretch near N-terminus.	Q7TZI7,A0A1R3XZD1	No	cell wall and cell processes			A0A1R3XZD1				IPR021368	Q7TZI7					Rv1797		Rv1797			
NC_002945.3	Mycobrowser_v4	CDS	2027155	2028987	.	+	0	Mb1826	ecca5		esx conserved component ecca5. esx-5 type vii secretion system protein.	Mb1826, -, len: 610 aa. Equivalent to Rv1798, len: 610 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 610 aa overlap). Conserved hypothetical protein, similar to several mycobacterial proteins e.g. O05460|MTCY15F10.28|Rv3884c|Z94121 from M. tuberculosis (619 aa), FASTA scores: opt: 669, E(): 0,(31.0% identity in 549 aa overlap); and O33089|MLCB628.18c|Y14967 from Mycobacterium leprae (573 aa), FASTA scores: opt: 723, E(): 0, (32.4% identity in 568 aa overlap). Also very similar to Rv0282. May belong to the CBXX/CFQX family as last ~320 aa domain very similar to several family members. Contains ATP/GTP-binding site motif A (P-loop; PS00017).	X2BJ83,P63745,P63745	No	cell wall and cell processes			P63745					X2BJ83,P63745					Rv1798		Rv1798			
NC_002945.3	Mycobrowser_v4	CDS	2029614	2029805	.	+	0	Mb1827	lppT		PROBABLE LIPOPROTEIN LPPT	Mb1827, lppT, len: 63 aa. Equivalent to Rv1799,len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Probable lppT lipoprotein, has possible signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TZI6,A0A1R3XZB0	No	cell wall and cell processes			A0A1R3XZB0					Q7TZI6					Rv1799		Rv1799			
NC_002945.3	Mycobrowser_v4	CDS	2029908	2031875	.	+	0	Mb1828	PPE28		ppe family protein ppe28	Mb1828, PPE28, len: 655 aa. Equivalent to Rv1800,len: 655 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 655 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, C-terminal very similar to parts of PE proteins e.g. Z92770|MTCI5.25|Rv0151c (588 aa), FASTA scores: opt: 1269, E(): 0, (41.5% identity in 591 aa overlap).	Q7TZI5,A0A1R3XZC0	No				A0A1R3XZC0				IPR000030,IPR013228	Q7TZI5										
NC_002945.3	Mycobrowser_v4	CDS	2038527	2038826	.	+	0	Mb1835	PE20		pe family protein pe20	Mb1835, PE20, len: 99 aa. Equivalent to Rv1806,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins, most similar to Rv1788|MTV049.10|AL022021 (99 aa), FASTA scores: opt: 334, E(): 4.7 e-15, (59.8% identity in 97 aa overlap).	Q7TZH9,A0A1R3XZE2	No	PE/PPE			A0A1R3XZE2				IPR000084	Q7TZH9					Rv1806		Rv1806			
NC_002945.3	Mycobrowser_v4	CDS	2035378	2037000	.	-	0	Mb1831c	PE_PGRS32b		PE-PGRS FAMILY PROTEIN [SECOND PART]	Mb1831c, PE_PGRS32b, len: 540 aa. Equivalent to 3' end of Rv1803c, len: 639 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 540 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Most similar to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt: 1827, E( ): 0, (53.5% identity in 664 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b, with PE_PGRS32a being truncated.	Q7TZI3,A0A1R3XZE5	No				A0A1R3XZE5					Q7TZI3										
NC_002945.3	Mycobrowser_v4	CDS	2037034	2037297	.	-	0	Mb1832c	PE_PGRS32a		PE-PGRS FAMILY PROTEIN [FIRST PART]	Mb1832c, PE_PGRS32a, len: 87 aa. Equivalent to 5' end of Rv1803c, len: 639 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 87 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Most similar to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt: 1827, E( ): 0, (53.5% identity in 664 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b, with PE_PGRS32a being truncated.	Q7TZI2,A0A1R3XZQ3	No				A0A1R3XZQ3				IPR000084	Q7TZI2										
NC_002945.3	Mycobrowser_v4	CDS	2038853	2040052	.	+	0	Mb1836	PPE31		ppe family protein ppe31	Mb1836, PPE31, len: 399 aa. Equivalent to Rv1807,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 399 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1789|MTV049.11|AL022021 (393 aa), FASTA scores: opt: 1169, E(): 0, (49.5% identity in 399 aa overlap). Start changed since original submission.	Q7TZH8,A0A1R3XZE3	No				A0A1R3XZE3				IPR000030,IPR022171	Q7TZH8										
NC_002945.3	Mycobrowser_v4	CDS	2040376	2041605	.	+	0	Mb1837	PPE32		ppe family protein ppe32	Mb1837, PPE32, len: 409 aa. Equivalent to Rv1808,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 409 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1800|MTV049.22|AL022021 (655 aa), FASTA scores: opt: 1225, E(): 0, (55.1% identity in 423 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. TBparse score is 0.919.	Q7TZH7,A0A1R3XZC6	No				A0A1R3XZC6				IPR000030,IPR022171	Q7TZH7										
NC_002945.3	Mycobrowser_v4	CDS	2041737	2042300	.	+	0	Mb1838	PPE33a		PPE FAMILY PROTEIN [FIRST PART]	Mb1838, PPE33a, len: 187 aa. Equivalent to 5' end of Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 187 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in 471 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits PPE33 into 2 parts, PPE33a and PPE33b, with PPE33a being truncated.	Q7TZH6,A0A1R3XZD0	No				A0A1R3XZD0				IPR000030	Q7TZH6										
NC_002945.3	Mycobrowser_v4	CDS	2043898	2044602	.	+	0	Mb1841	mgtC		POSSIBLE Mg2+ TRANSPORT P-TYPE ATPASE C MGTC	Mb1841, -, len: 234 aa. Equivalent to Rv1811, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Possible mgtC,magnesium (Mg2+) transport P-type ATPase C (transmembrane protein) (EC 3.6.3.1), highly similar to many e.g. NP_442124.1|NC_000911 Mg2+ transport ATPase from Synechocystis sp. strain PCC 6803 (234 aa); NP_251248.1|NC_002516 probable transport protein from Pseudomonas aeruginosa (230 aa); P22037|ATMC_SALTY|STM3764 magnesium transport ATPase protein C from Salmonella typhimurium (231 aa), FASTA scores: opt: 545, E(): 4.1e-30, (42.3% identity in 220 aa overlap); N-terminus of NP_213315.1|NC_000918 Mg(2+) transport ATPase from Aquifex aeolicus (225 aa); etc. BELONGS TO THE MGTC / SAPB FAMILY	Q7TZH4,A0A1R3Y076	No	cell wall and cell processes			A0A1R3Y076				IPR003416	Q7TZH4					Rv1811		Rv1811			
NC_002945.3	Mycobrowser_v4	CDS	2046976	2047878	.	+	0	Mb1844	erg3		MEMBRANE-BOUND C-5 STEROL DESATURASE ERG3 (STEROL-C5-DESATURASE)	Mb1844, erg3, len: 300 aa. Equivalent to Rv1814,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). erg3, transmembrane C-5 sterol desaturase (EC 1.3.-.-) (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). BELONGS TO THE STEROL DESATURASE FAMILY. [* note work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases].	X2BJ51,P68434,P68434	No	lipid metabolism			P68434					X2BJ51,P68434					Rv1814		Rv1814			
NC_002945.3	Mycobrowser_v4	CDS	2051633	2053138	.	-	0	Mb1849c	PE_PGRS33		pe-pgrs family protein pe_pgrs33	Mb1849c, PE_PGRS33, len: 501 aa. Equivalent to Rv1818c, len: 498 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 501 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see first citation),similar to many. Contains 2 x PS00583 pfkB family of carbohydrate kinases signature 1. Supposed localised to the cell surface. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp insertion (*-gccgccggc), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa).	Q7TZH0,A0A1R3XZD5	No				A0A1R3XZD5				IPR000084	Q7TZH0										
NC_002945.3	Mycobrowser_v4	CDS	2053273	2055192	.	-	0	Mb1850c	baca		probable drug-transport transmembrane atp-binding protein abc transporter baca	Mb1850c, -, len: 639 aa. Equivalent to Rv1819c,len: 639 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 639 aa overlap). Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), equivalent to AL008609|MLCB1788.47 hypothetical ABC transporter from Mycobacterium leprae (638 aa), (74.9% identity in 634 aa overlap). Also similar to other transmembrane ATP-binding proteins e.g. Q57335|Y036_HAEIN hypothetical ABC transporter ATP-binding protein from Haemophilus influenzae (592 aa), FASTA scores: opt: 1235, E(): 2.8e-61, (40.8% identity in 623 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TZG9,A0A1R3Y1K9	No	cell wall and cell processes			A0A1R3Y1K9				IPR003439,IPR003593,IPR010509,IPR011527,IPR017871,IPR027417	Q7TZG9					Rv1819c		Rv1819c			
NC_002945.3	Mycobrowser_v4	CDS	2055263	2056906	.	+	0	Mb1851	ilvG		Probable Acetolactate synthase ilvG (Acetohydroxy-acid synthase)(ALS)	Mb1851, ilvG, len: 547 aa. Equivalent to Rv1820,len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 547 aa overlap). Probable ilvG,acetolactate synthase (EC 4.1.3.18). Equivalent to AL008609|MLCB1788.46c ilvG from Mycobacterium leprae (548 aa) (86.1% identity in 548 aa overlap). Similar to ILVB_KLEPN|P27696 (559 aa), FASTA scores: opt: 660, E(): 2.9e-34, (29.1% identity in 549 aa overlap). Also similar to other Mycobacterium tuberculosis Ilv proteins e.g. Rv3003c (ilvB), etc. Contains PS00187 Thiamine pyrophosphate enzymes signature.	X2BJA5,P66947,P66947	No	intermediary metabolism and respiration			P66947					X2BJA5,P66947					Rv1820		Rv1820			
NC_002945.3	Mycobrowser_v4	CDS	2056921	2059347	.	+	0	Mb1852	secA2		possible preprotein translocase atpase seca2	Mb1852, secA2, len: 808 aa. Equivalent to Rv1821,len: 808 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 808 aa overlap). Possible secA2,preprotein translocase, component of secretion apparatus,similar to several preprotein translocases e.g. P28366|SECA_BACSU preprotein translocase secA subunit from Bacillus subtilis (841 aa), FASTA scores: opt: 1424, E(): 0, (35.9% identity in 786 aa overlap). Equivalent to AL008609|MLCB1788.45 Preprotein translocase SecA 2 from Mycobacterium leprae (778 aa) (87.1% identity in 780 aa overlap). Also similar to Rv3240c|MTCY20B11.15c secA preprotein translocase from Mycobacterium tuberculosis (949 aa). COULD BE PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c,SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732.	X2BJ36,P66786,P66786	No				P66786					X2BJ36,P66786										
NC_002945.3	Mycobrowser_v4	CDS	2059544	2060173	.	+	0	Mb1853	pgsA2		PROBABLE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE)	Mb1853, pgsA2, len: 209 aa. Equivalent to Rv1822,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable pgsA2,CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase (EC 2.7.8.5) (see citation below), integral membrane protein, equivalent to AL008609|MLCB1788_17 phosphatidyltransferase from Mycobacterium leprae (206 aa), FASTA score: (76.6% identity in 205 aa overlap). Also highly similar or similar to others e.g. CAB88885.1|AL353861 putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Streptomyces coelicolor (215 aa); AAC44003.1|U29587 phosphatidylglycerol phosphate synthase from Rhodobacter sphaeroides (227 aa); NP_405431.1|NC_003143 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Yersinia pestis (182 aa); P06978|PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (181 aa),FASTA scores: opt: 252, E(): 2.8e-09, (29.7% identity in 175 aa overlap); etc. Also similar to Rv2746c|PGSA3|MTV002.11c CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE (PGP SYNTHASE) from Mycobacterium tuberculosis (209 aa). Contains PS00379 CDP-alcohol phosphatidyltransferases signature; and PS00075 Dihydrofolate reductase signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY.	X2BIK7,P63754,P63754	No				P63754					X2BIK7,P63754										
NC_002945.3	Mycobrowser_v4	CDS	2062416	2062820	.	+	0	Mb1857	gcvH		PROBABLE GLYCINE CLEAVAGE SYSTEM H PROTEIN GCVH	Mb1857, gcvH, len: 134 aa. Equivalent to Rv1826,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Probable gcvH, glycine cleavage system H protein, highly similar to GCSH_ECOLI|P23884 glycine cleavage system H protein from Escherichia coli (129 aa), FASTA scores: opt: 428, E(): 2.2e-22, (47.8% identity in 134 aa overlap). Equivalent to MLCB1788.37c gcvH from Mycobacterium leprae (78.4% identity in 134 aa overlap). Contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. BELONGS TO THE GCVH FAMILY.	X2BJ41,Q7TZG8,Q7TZG8	No	intermediary metabolism and respiration			Q7TZG8					X2BJ41,Q7TZG8					Rv1826		Rv1826			
NC_002945.3	Mycobrowser_v4	CDS	2063060	2063548	.	+	0	Mb1858	gara		conserved protein with fha domain, gara	Mb1858, cfp17, len: 162 aa. Equivalent to Rv1827,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). cfp17, conserved hypothetical protein (see citation below), equivalent to O32919|MLCB1788.36c hypothetical protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 888,E(): 0, (87.0% identity in 161 aa overlap).	X2BIL3,P64898	No				P64898					X2BIL3										
NC_002945.3	Mycobrowser_v4	CDS	2066229	2069054	.	+	0	Mb1863	gcvB		Probable glycine dehydrogenase gcvB (Glycine decarboxylase) (Glycine cleavage system P-protein)	Mb1863, gcvB, len: 941 aa. Equivalent to Rv1832,len: 941 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 941 aa overlap). Probable gcvB, glycine dehydrogenase [decarboxylating] (EC 1.4.4.2), highly similar to GCSP_ECOLI|P33195 glycine dehydrogenase (decarboxylating) from Escherichia coli (957 aa), FASTA scores: opt: 2194, E(): 0, (55.4% identity in 961 aa overlap). THE GLYCINE CLEAVAGE SYSTEM IS COMPOSED OF FOUR PROTEINS: P, T, L, AND H.	X2BIL8,Q7VET8,Q7VET8	No	intermediary metabolism and respiration			Q7VET8					X2BIL8,Q7VET8					Rv1832		Rv1832			
NC_002945.3	Mycobrowser_v4	CDS	2087856	2088170	.	+	0	Mb1880	ureB		urease beta subunit ureb (urea amidohydrolase)	Mb1880, ureB, len: 104 aa. Equivalent to Rv1849,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). ureB, urease beta subunit (EC 3.5.1.5). Identical to URE2_MYCTU|P50048 urease beta subunit from Mycobacterium tuberculosis (100 aa). BELONGS TO THE UREASE GAMMA SUBUNIT FAMILY.	X2BJ38,P0A663,P0A663	No	intermediary metabolism and respiration			P0A663					X2BJ38,P0A663					Rv1849		Rv1849			
NC_002945.3	Mycobrowser_v4	CDS	2070182	2071048	.	+	0	Mb1865	lipz		Probable hydrolase	Mb1865, -, len: 288 aa. Equivalent to Rv1834, len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 288 aa overlap). Probable hydrolase (EC 3.-.-.-), some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kd protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap).	Q7VET7,A0A1R3XZJ0	No	intermediary metabolism and respiration			A0A1R3XZJ0				IPR000639	Q7VET7					Rv1834		Rv1834			
NC_002945.3	Mycobrowser_v4	CDS	2096782	2097891	.	+	0	Mb1890	modC		PROBABLE MOLYBDENUM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MODC	Mb1890, modC, len: 369 aa. Equivalent to Rv1859,len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 369 aa overlap). Probable modC,molybdenum-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. Y10817|ANY108176 ModC from Arthrobacter (349 aa), FASTA scores: opt: 895, E(): 0, (46.0% identity in 361 aa overlap); etc. Shows similarity to other Mycobacterium tuberculosis ABC-transporter proteins e.g. Rv0073, Rv1238,Rv2564, etc. Contains both PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signatures involved in molybdate uptake. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TZF4,A0A1R3Y1P5	No	cell wall and cell processes			A0A1R3Y1P5				IPR003439,IPR003593,IPR005116,IPR008995,IPR015852,IPR017871,IPR027417	Q7TZF4					Rv1859		Rv1859			
NC_002945.3	Mycobrowser_v4	CDS	2075108	2077333	.	-	0	Mb1868c	glcB		malate synthase g glcb	Mb1868c, glcB, len: 741 aa. Equivalent to Rv1837c,len: 741 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 741 aa overlap). Probable glcB, malate synthase G (EC 4.1.3.2) (see citations below), highly similar to MASY_CORGL|P42450 malate synthase (738 aa),FASTA score: opt: 2961, E(): 0, (61.3% identity in 724 aa overlap). BELONGS TO THE MALATE SYNTHASE G FAMILY.	X2BIM5,P0A5J5,P0A5J5	No				P0A5J5					X2BIM5,P0A5J5										
NC_002945.3	Mycobrowser_v4	CDS	2077609	2078004	.	-	0	Mb1869c	vapc13		possible toxin vapc13	Mb1869c, -, len: 131 aa. Equivalent to Rv1838c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein. Part of 14-membered Mycobacterium tuberculosis protein family with Rv2863|MTV003.09|AL008883 (126 aa), FASTA scores: opt: 293, E(): 1.5e-14, (38.2% identity in 123 aa overlap); Rv0749, Rv0277c, Rv2530c,etc. Also similar to AJ248288|CNSPAX06_181 Pyrococcus abyssi complete genome (136 aa), FASTA scores: opt: 197,E(): 2.2e-07, (33. 1% identity in 133 aa overlap).	X2BJ75,P64902,P64902	No	virulence, detoxification, adaptation			P64902					X2BJ75,P64902					Rv1838c		Rv1838c			
NC_002945.3	Mycobrowser_v4	CDS	2078323	2079723	.	-	0	Mb1871c	PE_PGRS34		pe-pgrs family protein pe_pgrs34	Mb1871c, PE_PGRS34, len: 466 aa. Similar to Rv1840c, len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, (90.485% identity in 515 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to many e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 1693, E(): 0, (53.1% identity in 612 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 147 bp leads to a longer protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa).	Q7TZG4,A0A1R3Y0B4	No				A0A1R3Y0B4				IPR000084	Q7TZG4										
NC_002945.3	Mycobrowser_v4	CDS	2088170	2089903	.	+	0	Mb1881	ureC		Urease alpha subunit ureC (Urea amidohydrolase)	Mb1881, ureC, len: 577 aa. Equivalent to Rv1850,len: 577 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 577 aa overlap). ureC, urease alpha subunit (EC 3.5.1.5). Similar to URE1_MYCTU|P50042 from M. tuberculosis (577 aa), FASTA scores: opt: 3794, E(): 0,(98.3% identity in 577 aa overlap). Contains PS00145 Urease active site motif. BELONGS TO THE UREASE FAMILY.	X2BJE0,P0A661,P0A661	No	intermediary metabolism and respiration			P0A661					X2BJE0,P0A661					Rv1850		Rv1850			
NC_002945.3	Mycobrowser_v4	CDS	2082476	2083915	.	-	0	Mb1874c	guaB1		PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	Mb1874c, guaB1, len: 479 aa. Equivalent to Rv1843c,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Probable guaB1,inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). Similar to others e.g. IMDH_BACSU|P21879 from Bacillus subtilis (513 aa), FASTA score: opt: 904, E(): 0, (37.8% identity in 471 aa overlap). Similar to other Mycobacterium tuberculosis proteins e.g. guaB2, Rv3411c.	X2BJ81,P65173,P65173	No				P65173					X2BJ81,P65173										
NC_002945.3	Mycobrowser_v4	CDS	2083281	2085338	.	-	0	Mb1875c	gnd1		PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1	Mb1875c, gnd1, len: 705 aa. Similar to 5' end of Rv1844c, len: 485 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 404 aa overlap). Probable gnd1, 6-phosphogluconate dehydrogenase (EC 1.1.1.44). Similar to others e.g. 6PGD_ECOLI|P00350 from Escherichia coli (468 aa), FASTA scores: opt: 1661, E(): 0, (53.6% identity in 466 aa overlap); etc. Also similar to Rv1122|MTCY22G8.11|gnd2 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING from Mycobacterium tuberculosis (340 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c is most similar to gnd's from Gram negative organisms, while Rv1122|MTCY22G8.11|gnd2 is most similar to gnd's from Gram positive organisms. BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (705 aa versus 485 aa).	Q7TZG1,A0A1R3XZK7	No				A0A1R3XZK7				IPR006113,IPR006114,IPR006115,IPR006184,IPR008927,IPR013328,IPR016040	Q7TZG1										
NC_002945.3	Mycobrowser_v4	CDS	2085428	2086378	.	-	0	Mb1876c	blar		possible sensor-transducer protein blar	Mb1876c, -, len: 316 aa. Equivalent to Rv1845c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 316 aa overlap). Conserved hypothetical transmembrane protein. Equivalent to MLCB1788.18|AL008609 Hypothetical protein from Mycobacterium leprae (316 aa), FASTA scores: opt: 1762,E(): 0, (87.6% identity in 314 aa overlap). Similar to proteins in Streptomyces coelicolor e.g. SC10A7.04|AL078618.1.	Q7TZG0,A0A1R3XZH7	No	cell wall and cell processes			A0A1R3XZH7				IPR001915	Q7TZG0					Rv1845c		Rv1845c			
NC_002945.3	Mycobrowser_v4	CDS	2087557	2087859	.	+	0	Mb1879	ureA		Urease gamma subunit ureA (Urea amidohydrolase)	Mb1879, ureA, len: 100 aa. Equivalent to Rv1848,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). ureA, urease gamma subunit (EC 3.5.1.5). Similar to URE3_MYCTU|P50043 from Mycobacterium tuberculosis (100 aa), FASTA scores: opt: 630, E(): 1.3e-36, (99.0% identity in 100 aa overlap). BELONGS TO THE UREASE GAMMA SUBUNIT FAMILY.	X2BJ86,P0A677,P0A677	No	intermediary metabolism and respiration			P0A677					X2BJ86,P0A677					Rv1848		Rv1848			
NC_002945.3	Mycobrowser_v4	CDS	2091860	2093251	.	-	0	Mb1885c	ndh		PROBABLE NADH DEHYDROGENASE NDH	Mb1885c, ndh, len: 463 aa. Equivalent to Rv1854c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 463 aa overlap). Probable ndh, NADH dehydrogenase (EC 1.6.99.3) (see citations below), similar to several e.g. S74826 NADH dehydrogenase from Synechocystis sp. (445 aa), FASTA score: opt: 1228, E(): 0, (46.3% identity in 432 aa overlap). Highly similar to Rv0392c|Z84725|g1817703 from Mycobacterium tuberculosis (470 aa), FASTA scores: opt: 1911, E(): 0, (64.7% identity in 459 aa overlap); and Rv1812c.	Q7TZF7,A0A1R3XZL7	No				A0A1R3XZL7				IPR001327,IPR013027,IPR023753	Q7TZF7										
NC_002945.3	Mycobrowser_v4	CDS	2095193	2095978	.	+	0	Mb1888	modA		PROBABLE MOLYBDATE-BINDING LIPOPROTEIN MODA	Mb1888, modA, len: 261 aa. Equivalent to Rv1857,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable modA,molybdate-binding protein attached to membrane by lipid-modified N-terminal cysteine (contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site),component of molybdate transport system (see citation below). Shows strong similarity to precursors of periplasmic molybdate/sulphate binding proteins e.g. O31229|Y10817|ANY108174 ModA from Arthrobacter nicotinovorans (260 aa), FASTA score: opt: 725, E(): 0,(47.8% identity in 249 aa overlap).	X2BIP4,P0A5Y1,P0A5Y1	No	cell wall and cell processes			P0A5Y1					X2BIP4,P0A5Y1					Rv1857		Rv1857			
NC_002945.3	Mycobrowser_v4	CDS	2095981	2096775	.	+	0	Mb1889	modB		probable molybdenum-transport integral membrane protein abc transporter modb	Mb1889, modB, len: 264 aa. Equivalent to Rv1858,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 264 aa overlap). Probable modB,molybdenum-transport integral membrane protein ABC transporter (see citation below), similar to others e.g. Y10817|ANY108175 ModB from Arthrobacter (239 aa), FASTA scores: opt: 937, E(): 0, (67.8% identity in 230 aa overlap); etc. Similar to other Mycobacterium tuberculosis transport proteins e.g. Rv2039c, Rv2316, etc.	X2BJ95,P0A625,P0A625	No	cell wall and cell processes			P0A625					X2BJ95,P0A625					Rv1858		Rv1858			
NC_002945.3	Mycobrowser_v4	CDS	2097944	2098921	.	+	0	Mb1891	apa		ALANINE AND PROLINE RICH SECRETED PROTEIN APA (FIBRONECTIN ATTACHMENT PROTEIN) (Immunogenic protein MPT32) (Antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)	Mb1891, apa, len: 325 aa. Equivalent to Rv1860,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 325 aa overlap). apa (alternate gene names: mpt32, modD), Ala-, Pro-rich 45/47 kDa secreted protein, very similar to P46842|N43L_MYCLE from Mycobacterium leprae (287 aa), FASTA scores: opt: 1166,E(): 0, (66.4% identity in 298 aa overlap). Known to be glycosylated fibronectin-binding protein (see some citations). TBparse score is 0.924.	X2BJF2,O30620,O30620	No	cell wall and cell processes			O30620					X2BJF2,O30620					Rv1860		Rv1860			
NC_002945.3	Mycobrowser_v4	CDS	2099753	2100793	.	+	0	Mb1893	adhA		Probable alcohol dehydrogenase adhA	Mb1893, adhA, len: 346 aa. Equivalent to Rv1862,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap=. Probable adhA,alcohol dehydrogenase (EC 1.1.1.1), similar to ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature.	Q7VET4,A0A1R3XZX7	No	intermediary metabolism and respiration			A0A1R3XZX7				IPR002085,IPR002328,IPR011032,IPR013149,IPR013154,IPR014187,IPR016040	Q7VET4					Rv1862		Rv1862			
NC_002945.3	Mycobrowser_v4	CDS	2112116	2113360	.	-	0	Mb1903c	lldD2		POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2	Mb1903c, lldD2, len: 414 aa (start uncertain). Equivalent to Rv1872c, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 414 aa overlap). Possible lldD2, L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar to other lactate dehydrogenases and other oxidases e.g. LLDD_ECOLI|P33232 l-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa), FASTA results: opt: 674, E(): 1.1e-37, (40.5% identity in 279 aa overlap); Q51135 LACTATE DEHYDROGENASE from Neisseria meningitidis (390 aa), FASTA results: opt: 309, E(): 4.1e-15, (42.5% identity in 113 aa overlap); etc. Also shows similarity with Rv0694|lldD1|MTCY210.11 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis (396 aa). Contains PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY.	Q7TZE4,A0A1R3XZY8	No	intermediary metabolism and respiration			A0A1R3XZY8				IPR000262,IPR008259,IPR012133,IPR013785	Q7TZE4					Rv1872c		Rv1872c			
NC_002945.3	Mycobrowser_v4	CDS	2115549	2116028	.	+	0	Mb1907	bfrA		PROBABLE BACTERIOFERRITIN BFRA	Mb1907, bfrA, len: 159 aa. Equivalent to Rv1876,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable bfrA,bacterioferritin, similar to BFR_MYCLE|P43315 bacterioferritin (bfr) from Mycobacterium leprae (159 aa),FASTA results: opt: 958, E(): 0, (90.6% identity in 159 aa overlap). Also similar to Rv3841|MTCY01A6.28c|bfrB POSSIBLE BACTERIOFERRITIN from Mycobacterium tuberculosis (181 aa). BELONGS TO THE BACTERIOFERRITIN FAMILY.	X2BJ97,P63698,P63698	No	intermediary metabolism and respiration			P63698					X2BJ97,P63698					Rv1876		Rv1876			
NC_002945.3	Mycobrowser_v4	CDS	2118232	2119584	.	+	0	Mb1910	glnA3		PROBABLE GLUTAMINE SYNTHETASE GLNA3 (GLUTAMINE SYNTHASE) (GS-I)	Mb1910, glnA3, len: 450 aa. Equivalent to Rv1878,len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 450 aa overlap). Probable glnA3,glutamine synthetase class I (EC 6.3.1.2), similar to many e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa),FASTA results: opt: 497, E(): 5.2e-23, (29.0% identity in 331 aa overlap); etc. Also similar to C-terminus of FLUG_EMENI|P38094 flug protein from emericella nidulans (865 aa), FASTA scores: opt: 227, E (): 6.4e-13, (29.9% identity in 394 aa overlap). Note that the downstream ORF MTCY180.39c is similar to the N-terminus. Also similar to three other potential glutamine synthases in M. tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427 .03c; Rv2860c|MTV003.06c|glnA4 and Rv2220|glnA1. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY.	Q7TZD8,A0A1R3Y1R5	No				A0A1R3Y1R5				IPR008146,IPR014746	Q7TZD8										
NC_002945.3	Mycobrowser_v4	CDS	2120751	2122067	.	-	0	Mb1912c	cyp140		Probable cytochrome p450 140 CYP140	Mb1912c, cyp140, len: 438 aa. Equivalent to Rv1880c, len: 438 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 438 aa overlap). Probable cyp140, cytochrome p450 (EC 1.14.-.-). Similar to Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase (404 aa), FASTA scores: opt: 775, E(): 0, (44.2% identity in 319 aa overlap); and other members of the cytochrome P450 family. Related to Mycobacterium tuberculosis proteins include: Rv0766c, Rv2266, Rv0778, etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY.	X2BJA3,P63722,P63722	No	intermediary metabolism and respiration			P63722					X2BJA3,P63722					Rv1880c		Rv1880c			
NC_002945.3	Mycobrowser_v4	CDS	2122117	2122539	.	-	0	Mb1913c	lppE		POSSIBLE CONSERVED LIPOPROTEIN LPPE	Mb1913c, lppE, len: 140 aa. Equivalent to Rv1881c,len: 140 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 140 aa overlap=. Possible lppE,lipoprotein, showing some similarity to L12238|MSG18S19K_1 19K antigen from Mycobacterium intracellulare (162 aa),FASTA scores: opt: 137, E(): 0.0069, (27.6% identity in 156 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TZD6,A0A1R3XZZ9	No				A0A1R3XZZ9					Q7TZD6										
NC_002945.3	Mycobrowser_v4	CDS	2123956	2124486	.	-	0	Mb1916c	rpfC		PROBABLE RESUSCITATION-PROMOTING FACTOR RPFC	Mb1916c, rpfC, len: 176 aa. Equivalent to Rv1884c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Probable rpfC,resuscitation promoting factor (see citation below),similar to Z96935|MLRPF_1 resusicitation-promoting factor from Micrococcus luteus (220 aa), FASTA score: opt: 287,E() : 3.3e-11, (40.0% identity in 120 aa overlap). Also similar to others from Mycobacterium tuberculosis: Rv2389c|MTCY253.32|RPFD PROBABLE RESUSCITATION-PROMOTING FACTOR (154 aa), FASTA score: opt: 382, E(): 7.1e-17,(55.4% identity in 101 aa overlap); Rv0867c|RPFA (N-terminal part), Rv2450c|RPFE, and Rv1009|RPFB (C-terminal part).	Q7TZD3,A0A1R3XZM2	No				A0A1R3XZM2				IPR010618,IPR023346	Q7TZD3										
NC_002945.3	Mycobrowser_v4	CDS	2125115	2126092	.	-	0	Mb1918c	fbpB		secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (Fibronectin-binding protein B) (Extracellular alpha-antigen)	Mb1918c, fbpB, len: 325 aa. Equivalent to Rv1886c,len: 325 aa, from Mycobacterium tuberculosis strain H37Rv (100.0% identity in 325 aa overlap). fbpB (alternate gene names: mpt59, 85B), precursor of the 85-B antigen (fibronectin-binding protein B) (mycolyl transferase 85B) (EC 2.3.1.-) (see citations below), highly similar to other Mycobacterial antigen precursors e.g. P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from Mycobacterium bovis (323 aa); P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR from Mycobacterium kansasii (325 aa); etc. Also highly similar to Mycobacterium tuberculosis antigen precursors: Rv3804c|fbpA (338 aa), Rv0129c|fbpC2 (340 aa),and Rv3803c|fbpC1 (299 aa).	X2BIS9,P0C2T2,P0C2T2	No				P0C2T2					X2BIS9,P0C2T2										
NC_002945.3	Mycobrowser_v4	CDS	2135449	2136525	.	-	0	Mb1934c	lppD		POSSIBLE LIPOPROTEIN LPPD	Mb1934c, lppD, len: 358 aa. Similar to Rv1899c,len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(95.5% identity in 358 aa overlap). Possible lipoprotein; contains appropriately localized lipoprotein lipid attachment site (PS00013). Some similarity to C-terminal part of AE000717|AE000717_4 hypothetical protein from Aquifex aeolicus section 49 (165 aa), FASTA results: opt: 372, E(): 2.3e-14, (43.5% identity in 147 aa overlap); and Q44020 4-hydroxybutyrate dehydrogenase (173 aa), FASTA results: opt: 272, E(): 4.7e-09, (35.8% identity in 165 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa).	X2BIV1,Q7TZB9	No				Q7TZB9					X2BIV1										
NC_002945.3	Mycobrowser_v4	CDS	2136525	2137913	.	-	0	Mb1935c	lipJ		PROBABLE LIGNIN PEROXIDASE LIPJ	Mb1935c, lipJ, len: 462 aa. Equivalent to Rv1900c,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 462 aa overlap). Probable lipJ, lignin peroxidase, with some similarity to esterases, hydrolases and hypothetical Mycobacterium tuberculosis proteins e.g. Q43936 BETA-KETOADIPATE ENOL-LACTONE HYDROLASE from Acinetobacter calcoaceticus (267 aa), FASTA results: opt: 217, E(): 1.7e-07, (29.2% identity in 260 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv2212|Q10400|YM12_MYCTU (378 aa), FASTA results: opt: 216, E(): 6.7e-07, (27.7% identity in 285 aa overlap).	Q7TZB8,A0A1R3XZM9	No				A0A1R3XZM9				IPR001054	Q7TZB8										
NC_002945.3	Mycobrowser_v4	CDS	2137942	2139234	.	+	0	Mb1936	cinA		PROBABLE CINA-LIKE PROTEIN CINA	Mb1936, cinA, len: 430 aa. Equivalent to Rv1901,len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 430 aa overlap). Probable cinA-like protein, strong similarity to competence damage proteins CinA of Bacillus subtilis and S. pneumoniae. FASTA results: Q55760 HYPOTHETICAL 44.7 KD PROTEIN (416 aa) opt: 755, E(): 0, (36.0% identity in 433 aa overlap).	X2BJ98,P63776,P63776	No	virulence, detoxification, adaptation			P63776					X2BJ98,P63776					Rv1901		Rv1901			
NC_002945.3	Mycobrowser_v4	CDS	2139286	2140554	.	-	0	Mb1937c	nanT		PROBABLE SIALIC ACID-TRANSPORT INTEGRAL MEMBRANE PROTEIN NANT	Mb1937c, nanT, len: 422 aa. Equivalent to Rv1902c,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Probable nanT, sialic acid-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. Q48076 SIALIC ACID TRANSPORTER (407 aa), FASTA results: opt: 443, E(): 5.4e-22, (26.7% identity in 389 aa overlap); etc. Some similarity to MTCI364.12|O05301 conserved hypothetical protein from Mycobacterium tuberculosis (425 aa), FASTA results: opt: 251, E(): 1.1e-09, (23.5% identity in 417 aa overlap). Contains sugar transport proteins signature 2 (PS00217).	Q7TZB7,A0A1R3XZN8	No				A0A1R3XZN8				IPR004742,IPR005828,IPR005829,IPR016196,IPR020846	Q7TZB7										
NC_002945.3	Mycobrowser_v4	CDS	2141713	2142675	.	-	0	Mb1940c	aao		probable d-amino acid oxidase aao	Mb1940c, aao, len: 320 aa. Equivalent to Rv1905c,len: 320 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 320 aa overlap). Probable aao, D-amino acid oxidase (EC 1.4.3.3), similar to many. Equivalent to AJ000521|MLCOSL672.02|O33145 Mycobacterium leprae (320 aa), FASTA results: opt: 1541, E(): 0, (71.7% identity in 315 aa overlap); also similar to OXDD_BOVIN|P31228 d-aspartate oxidase (EC 1.4.3.1) from bos taurus (338 aa),FASTA results: opt: 461, E(): 1.1e-21, (31.8% identity in 321 aa overlap).	Q7TZB4,A0A1R3XZP0	No				A0A1R3XZP0				IPR006076,IPR016040,IPR023209	Q7TZB4										
NC_002945.3	Mycobrowser_v4	CDS	2144169	2146391	.	-	0	Mb1943c	katG		CATALASE-PEROXIDASE-PEROXYNITRITASE T KATG	Mb1943c, katG, len: 740 aa. Equivalent to Rv1908c,len: 740 aa, from Mycobacterium tuberculosis strain H37Rv (99.9% identity in 740 aa overlap). katG,catalase-peroxidase-peroxynitritase T (EC 1.11.1.6) (see citations below), HPI. FASTA results: Q57215 CATALASE-PEROXIDASE from Mycobacterium tuberculosis (740 aa) opt: 5081, E(): 0, (100% identity in 740 aa overlap). Contains peroxidases active site signature (PS00436) and ATP/GTP-binding site motif A (P-loop; PS00017). Cosmid sequence was corrected to agree with a sequencing read from the H37Rv genome. DELETIONS OR DEFECTS IN KATG GENE CAUSE ISONIAZID (INH) RESISTANCE. BELONGS TO THE PEROXIDASE FAMILY. BACTERIAL PEROXIDASE/CATALASE SUBFAMILY. KATG TRANSCRIPTION SEEMS TO BE REGULATED BY FURA|Rv1909c PRODUCT. The catalase-peroxidase activity is associated with the amino-terminal domain but no definite function has been assigned to the carboxy-terminal domain.	X2BJE1,P46817,P46817	No				P46817					X2BJE1,P46817										
NC_002945.3	Mycobrowser_v4	CDS	2146429	2146872	.	-	0	Mb1944c	furA		Ferric uptake regulation protein FurA (fur)	Mb1944c, len: 147 aa. Equivalent to Rv1909c len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). FurA, Ferric uptake regulation protein, similar to Q48835 legionella pneumophila 130B (wadsworth) ferric uptake regulation (136 aa), FASTA results: opt: 230, E(): 2.5e-09, (32.3% identity in 133 aa overlap). Also similar to Mycobacterium tuberculosis zur zinc uptake regulatory protein, Rv2359. Belongs to the fur family. Start changed since original submission (-3 aa).	X2BIW7,P0A583,P0A583	No	regulatory proteins			P0A583					X2BIW7,P0A583					Rv1909c		Rv1909c			
NC_002945.3	Mycobrowser_v4	CDS	2147662	2148267	.	-	0	Mb1946c	lppC		PROBABLE LIPOPROTEIN LPPC	Mb1946c, lppC, len: 201 aa. Equivalent to Rv1911c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable lipoprotein lppC, contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS00013). Very similar to downstream ORF MTCY180.08 (204 aa) (although this lacks lipoprotein motif), FASTA score: opt: 831, E(): 0, (64.0% identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN HYPOTHETICAL PROTEIN CPN0877 from Chlamydia pneumoniae (strain CWL029) (150 aa).	X2BJB0,P67225	No				P67225					X2BJB0										
NC_002945.3	Mycobrowser_v4	CDS	2148367	2149371	.	-	0	Mb1947c	fadB5		POSSIBLE OXIDOREDUCTASE FADB5	Mb1947c, fadB5, len: 334 aa. Equivalent to Rv1912c,len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 334 aa overlap). Possible fadB5,oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35), quinone oxidoreductases (EC 1.6.5.5), and polyketide synthases, e.g. NP_104067.1|NC_002678 probable oxidoreductase from Mesorhizobium loti (308 aa); NP_464140.1|NC_003210 protein similar to oxidoreductase from Listeria monocytogenes (313 aa); NP_193889.1|NC_003075 putative NADPH quinone oxidoreductase from Arabidopsis thaliana (325 aa); NP_001880.2|NM_001889 crystallin, zeta; quinone oxidoreductase; NADPH:quinone reductase from Homo sapiens (329 aa); part 2983 to 3197 of T17410 polyketide synthase type I from Streptomyces venezuelae (3739 aa); Q53927|SCBAC20F6.16 HYDROXYACYL-COA DEHYDROGENASE from Streptomyces coelicolor (329 aa), FASTA scores: opt: 621,E(): 2e-30, (39.5% identity in 349 aa overlap); etc. Also similar to many hypothetical Mycobacterium tuberculosis proteins including: MTCY24G1.09, MTCY13D12.11,MTCY19H9.01, MTCY24G1.03, MTCY03A2.17c, etc. Contains quinone oxidoreductase/zeta-crystallin signature (PS01162).	Q7TZB1,A0A1R3XZP6	No				A0A1R3XZP6				IPR002085,IPR002364,IPR011032,IPR013154,IPR016040	Q7TZB1										
NC_002945.3	Mycobrowser_v4	CDS	2150743	2153043	.	+	0	Mb1950	aceA		probable isocitrate lyase aceab [second part] (isocitrase) (isocitratase) (icl)	Mb1950, aceA, len: 766 aa. Similar to Rv1915 and Rv1916, len: 367 aa and 398 aa, from Mycobacterium tuberculosis strain H37Rv, (89.1% identity in 339 aa overlap and 100.0% identity in 398 aa overlap). Probable aceA, isocitrate lyase (EC 4.1.3.1). Contains PS00161 Isocitrate lyase signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-t) leads to a single product.	Q7TZA8,Q7TZA8	No				Q7TZA8				IPR006254,IPR015813,IPR018523	Q7TZA8										
NC_002945.3	Mycobrowser_v4	CDS	2153213	2158945	.	-	0	Mb1951c	PPE34		ppe family protein ppe34	Mb1951c, PPE34, len: 1910 aa. Similar to Rv1917c,len: 1459 aa, from Mycobacterium tuberculosis strain H37Rv. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, MPTR subfamily (see citation below). Similar to MTCY28.16, MTCY13E10.17, MTCY63.10,MTV004.05 , MTCY98.24, MTCY6G11.05, etc. C-terminus is identical to Q50471. Unknown Mycobacterium tuberculosis protein (693 aa), FASTA results: opt: 2635, E(): 0, (99.7% identity in 391 aa overlap). Start changed since original submission (+23 aa). Thougth to be surface exposed,cell-wall associated. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, deletions of 12 bp and 69 bp,insertions of 483 bp and 375 bp, and a large substitution of 52 bp to 628 bp, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1910 aa versus 1459 aa).	Q7TZA7,A0A1R3Y1U1	No				A0A1R3Y1U1				IPR000030,IPR002989	Q7TZA7										
NC_002945.3	Mycobrowser_v4	CDS	2159283	2160287	.	-	0	Mb1952c	PPE35b		PPE FAMILY PROTEIN	Mb1952c, PPE35b, len: 334 aa. Equivalent to 3' end of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis strain H37Rv, (99.1% identity in 334 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 M. tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404,E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23,MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36,MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts,PPE35a and PPE35b.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2160370	2162247	.	-	0	Mb1953c	PPE35a		PPE FAMILY PROTEIN	Mb1953c, PPE35a, len: 625 aa. Equivalent to 5'end of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 599 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 M. tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404,E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23,MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36,MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts,PPE35a and PPE35b.	Q7TZA6,A0A1R3XZR2	No				A0A1R3XZR2				IPR000030,IPR002989	Q7TZA6										
NC_002945.3	Mycobrowser_v4	CDS	2164159	2165430	.	-	0	Mb1956c	lppF		PROBABLE CONSERVED LIPOPROTEIN LPPF	Mb1956c, lppF, len: 423 aa. Equivalent to Rv1921c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 423 aa overlap). Probable lppF,conserved lipoprotein, similar to G403173 lipoprotein precursor (fragment) from Rhodococcus erythropolis (225 aa), fasta scores: opt: 364, E(): 9.2e-19, (41.9% identity in 148 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TZA3,A0A1R3XZS0	No				A0A1R3XZS0				IPR023214	Q7TZA3										
NC_002945.3	Mycobrowser_v4	CDS	2166808	2168148	.	+	0	Mb1958	lipD		PROBABLE LIPASE LIPD	Mb1958, lipD, len: 446 aa. Equivalent to Rv1923,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 446 aa overlap). Probable lipD,hydrolase lipase (EC 3.1.-.-), similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569, E(): 5.4e-29, (33.7% identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc.	Q7TZA1,A0A1R3XZP8	No	intermediary metabolism and respiration			A0A1R3XZP8				IPR001466,IPR012338	Q7TZA1					Rv1923		Rv1923			
NC_002945.3	Mycobrowser_v4	CDS	2168722	2170584	.	+	0	Mb1960	fadD31		PROBABLE ACYL-COA LIGASE FADD31 (ACYL-COA SYNTHETASE) (ACYL-COA SYNTHASE)	Mb1960, fadD31, len: 620 aa. Equivalent to Rv1925,len: 620 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 620 aa overlap). Probable fadD31,acyl-CoA synthetase (EC 6.2.1.-), highly similar to others from Mycobacterium leprae e.g. NP_301198.1|NC_002677 putative acyl-CoA synthetase (635 aa); NP_302537.1|NC_002677 probable acyl-CoA synthase (583 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD32 (637 aa); fadD21 (578 aa); fadD29 (619 aa); fadD26|FD26_MYCTU|Q10976 (626 aa), FASTA scores: opt: 945, E(): 0, (39.8% identity in 598 aa overlap); etc. Also similar to N-terminus of G1171128 SAFRAMYCIN MX1 SYNTHETASE B from Myxococcus xanthus (1770 aa), FASTA scores: opt: 845, E(): 0, (37.4% identity in 593 aa overlap); N-terminus of T34918 polyketide synthase from Streptomyces coelicolor (2297 aa); etc.	Q7TZ99,A0A1R3XZQ8	No				A0A1R3XZQ8				IPR000873	Q7TZ99										
NC_002945.3	Mycobrowser_v4	CDS	2298267	2298572	.	-	0	Mb2082c	rpsN2		30s ribosomal protein s14 rpsn2	Mb2082c, rpsN2, len: 101 aa. Equivalent to Rv2056c,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Probable rpsN2,ribosomal protein S14, similar to others e.g. RS14_ECOLI|P02370 30S ribosomal protein S14 from Escherichia coli (100 aa), FASTA scores: opt: 290; E(): 1.7e- 13; (46.0% identity in 100 aa overlap); etc. Also similar to rpsN|Rv0717|MTCY210.36 from Mycobacterium tuberculosis, (50.0% identity in 62 aa overlap).	X2BJM0,P66406,P66406	No				P66406					X2BJM0,P66406										
NC_002945.3	Mycobrowser_v4	CDS	2170592	2171071	.	-	0	Mb1961c	mpt63		immunogenic protein mpt63 (antigen mpt63/mpb63) (16 kda immunoprotective extracellular protein)	Mb1961c, mpt63, len: 159 aa. Equivalent to Rv1926c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). mpt63 (alternate gene name: mpb63), immunogenic protein (see citations below),identical to MPT63|MPB63 from Mycobacterium bovis (159 aa). Exported protein containing a N-terminal signal sequence: see notes below about proteomics.	X2BJC5,P0A5Q3,P0A5Q3	No				P0A5Q3					X2BJC5,P0A5Q3										
NC_002945.3	Mycobrowser_v4	CDS	2298574	2298738	.	-	0	Mb2083c	rpmG1		50s ribosomal protein l33 rpmg1	Mb2083c, rpmG1, len: 54 aa. Equivalent to Rv2057c,len: 54 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 54 aa overlap). Probable rpmG1,ribosomal protein L33. FASTA results: RL33_ECOLI P02436 50S ribosomal protein L33 (54 aa) opt: 183; E(): 1.6e-09; 51.0% identity in 49 aa overlap. Note that previously known as rpmG.	X2BJX5,P0A5W1,P0A5W1	No				P0A5W1					X2BJX5,P0A5W1										
NC_002945.3	Mycobrowser_v4	CDS	2175007	2175504	.	+	0	Mb1967	tpx		PROBABLE THIOL PEROXIDASE TPX	Mb1967, tpx, len: 165 aa. Equivalent to Rv1932,len: 165 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 165 aa overlap). Probable tpx (alternate gene name: cfp20), thiol peroxidase (EC 1.11.1.-) similar to TPX_ECOLI|P37901 thiol peroxidase (EC 1.11.1.-) (p20) from Escherichia coli (167 aa), fasta scores: opt: 535, E(): 7.3e-25, (52.4% identity in 164 aa overlap). There are four other related enzymes in M. tuberculosis: Rv2428, Rv2521, Rv2238c, Rv1608c.	X2BJP5,P66953,P66953	No	virulence, detoxification, adaptation			P66953					X2BJP5,P66953					Rv1932		Rv1932			
NC_002945.3	Mycobrowser_v4	CDS	2175501	2176592	.	-	0	Mb1968c	fadE18		PROBABLE ACYL-COA DEHYDROGENASE FADE18	Mb1968c, fadE18, len: 363 aa. Equivalent to Rv1933c, len: 363 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 363 aa overlap). Probable fadE18, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (362 aa); NP_421282.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (344 aa); ACDS_RAT|P15651 short-chain specific acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 aa), fasta scores: opt: 239, E(): 2.1e-08, (28.4% identity in 331 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. N-terminus of fadE22 (721 aa); fadE33 (318 aa); N-terminus of fadE34 (711 aa); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	I3NIG1,A0A1R3XZR1	No	lipid metabolism			A0A1R3XZR1				IPR006091,IPR009075,IPR009100,IPR013786	I3NIG1					Rv1933c		Rv1933c			
NC_002945.3	Mycobrowser_v4	CDS	2176594	2177823	.	-	0	Mb1969c	fadE17		PROBABLE ACYL-COA DEHYDROGENASE FADE17	Mb1969c, fadE17, len: 409 aa. Equivalent to Rv1934c, len: 409 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 409 aa overlap). Probable fadE17, acyl-CoA dehydrogenase (EC 1.3.99.-),highly similar to ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium leprae (389 aa), FASTA scores: opt: 414, E(): 2.6e-19, (28.3% identity in 407 aa overlap). Also similar to many e.g. NP_249713.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (381 aa); NP_420614.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (355 aa); CAB61610.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (393 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE30 (385 aa); fadE31 (377 aa); C-terminus of fadE34 (711 aa); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	I3NIG0,A0A1R3XZU2	No	lipid metabolism			A0A1R3XZU2				IPR006091,IPR009075,IPR009100,IPR013786	I3NIG0					Rv1934c		Rv1934c			
NC_002945.3	Mycobrowser_v4	CDS	2177838	2178794	.	-	0	Mb1970c	echA13		POSSIBLE ENOYL-COA HYDRATASE ECHA13 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb1970c, echA13, len: 318 aa. Equivalent to Rv1935c, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 318 aa overlap). Possible echA13, enoyl-CoA hydratase (EC 4.2.1.17),similar to others and various enzymes e.g. CAC48381.1|Y16952 putative enoyl-CoA-isomerase from Amycolatopsis mediterranei (269 aa); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa); AAF78820.1|AF042490 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. TM1 (276 aa); ECHM_RAT|P14604 enoyl-coa hydratase mitochondrial precursor from Rattus norvegicus (Rat) (290 aa), FASTA scores: opt: 228, E( ): 1.2e-08, (31.0% identity in 258 aa overlap); etc.	I3NIF9,A0A1R3XZR7	No	lipid metabolism			A0A1R3XZR7				IPR001753	I3NIF9					Rv1935c		Rv1935c			
NC_002945.3	Mycobrowser_v4	CDS	2195315	2195611	.	-	0	Mb1994c	pare1		possible toxin pare1	Mb1994c, -, len: 98 aa. Equivalent to Rv1959c, len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Conserved hypothetical protein, similar to other hypothetical plasmid proteins e.g. AL117189|YPCD1.08 from Yersinia pestis (99 aa), FASTA scores: opt: 162, E(): 7.3e-05, (33.0% identity in 91 aa overlap); also some similarity to E145339 hypothetical protein (103 aa), FASTA scores: opt: 142, E(): 0.0003,(33.0% identity in 91 aa overlap).	Q7TZ73,A0A1R3XZU3	No	virulence, detoxification, adaptation			A0A1R3XZU3				IPR007712,IPR028344	Q7TZ73					Rv1959c		Rv1959c			
NC_002945.3	Mycobrowser_v4	CDS	2182662	2183732	.	+	0	Mb1973	ephB		PROBABLE EPOXIDE HYDROLASE EPHB (EPOXIDE HYDRATASE)	Mb1973, ephB, len: 356 aa. Equivalent to Rv1938,len: 356 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Probable ephB,epoxide hydrolase (EC 3.3.2.3) (see citation below),similar to many e.g. G1109600 ATSEH (EC 3.3.2.3) (321 aa),FASTA scores: opt: 442, E(): 1.2e-21 (33.1% identity in 356 aa overlap); etc. Also similar to many other M. tuberculosis hypothetical epoxide hydrolases e.g. Rv3617,Rv3670, Rv0134, etc.	Q7TZ94,A0A1R3XZT6	No	virulence, detoxification, adaptation			A0A1R3XZT6				IPR000073,IPR000639	Q7TZ94					Rv1938		Rv1938			
NC_002945.3	Mycobrowser_v4	CDS	2184240	2185301	.	+	0	Mb1975	ribA1		Probable Riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II)	Mb1975, ribA1, len: 353 aa. Equivalent to Rv1940,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 353 aa overlap). Probable ribA1,Riboflavin biosynthesis protein (EC 3.5.4.25), similar to GCH2_BACSU|P17620 gtp cyclohydrolase ii (EC 3.5.4.25) (398 aa), FASTA scores: opt: 682, E(): 0, (37.7% identity in 363 aa overlap), also similar to Rv1415|MTCY21B4.33|ribA2 (428 aa) (45.4% identity in 368 aa overlap). Note that previously known as ribA.	Q7TZ92,A0A1R3XZS4	No				A0A1R3XZS4				IPR000422,IPR000926,IPR016299,IPR017945	Q7TZ92										
NC_002945.3	Mycobrowser_v4	CDS	2186278	2186607	.	-	0	Mb1977c	mazf5		possible toxin mazf5	Mb1977c, -, len: 109 aa. Equivalent to Rv1942c,len: 109 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 109 aa overlap). Conserved hypothetical protein, shows some similarity to Q10867|MTCY39.28|Rv1991 hypothetical 12.3 kd protein (114 aa), FASTA scores: opt: 117, E(): 0.021, (24. 5% identity in 110 aa overlap) also P33645|CHPA_ECOLI pemk-like protein 1 (mazf protein) from Escherichia coli (111 aa),FASTA scores: opt: 104, E(): 0.18, (29.1% identity in 110 aa overlap). Also similar to Mycobacterium tuberculosis Rv0659c (102 aa) (32.7% identity in 101 aa overlap); Rv1102c (33.3% identity in 93 aa overlap) and Rv1495.	Q7TZ90,A0A1R3XZS9	No	virulence, detoxification, adaptation			A0A1R3XZS9				IPR003477,IPR011067	Q7TZ90					Rv1942c		Rv1942c			
NC_002945.3	Mycobrowser_v4	CDS	2189142	2189594	.	-	0	Mb1981c	lppG		POSSIBLE LIPOPROTEIN	Mb1981c, lppG, len: 150 aa. Equivalent to Rv1946c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TZ86,A0A1R3Y1W8	No				A0A1R3Y1W8					Q7TZ86										
NC_002945.3	Mycobrowser_v4	CDS	2192360	2192575	.	+	0	Mb1987	vapb14		possible antitoxin vapb14	Mb1987, -, len: 71 aa. Equivalent to Rv1952, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Conserved hypothetical protein. Some similarity to P55510|Y4JJ_RHISN PUTATIVE PLASMID STABILITY PROTEIN (85 aa), FASTA scores: opt: 127,E(): 0.00096, (42.5% identity in 73 aa overlap).	Q7TZ80,A0A1R3XZT8	No	virulence, detoxification, adaptation			A0A1R3XZT8				IPR010985	Q7TZ80					Rv1952		Rv1952			
NC_002945.3	Mycobrowser_v4	CDS	2192572	2192883	.	+	0	Mb1988	vapc14		possible toxin vapc14	Mb1988, -, len: 103 aa. Equivalent to Rv1953, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Conserved hypothetical protein. Some similarity to O33827 PLASMID STABILITY-LIKE PROTEIN from Thiobacillus ferrooxidans (143 aa), FASTA scores: opt: 170, E(): 3.5e-06, (45.3% identity in 75 aa overlap).	Q7TZ79,A0A1R3XZT3	No	virulence, detoxification, adaptation			A0A1R3XZT3					Q7TZ79					Rv1953		Rv1953			
NC_002945.3	Mycobrowser_v4	CDS	2213221	2213565	.	-	0	Mb2014c	mazf6		toxin mazf6	Mb2014c, -, len: 114 aa. Equivalent to Rv1991c,len: 114 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 114 aa overlap). Conserved hypothetical protein, showing some similarity to P13976|PEMK_ECOLI pemk protein (133 aa), FASTA scores: opt: 113, E(): 0.043, (29.2% identity in 113 aa overlap); and P96622|YDCE PROTEIN from Bacillus subtilis (116 aa),FASTA scores: opt: 227, E(): 6.9e-09, (37.4% identity in 115 aa overlap). Also similar to Mycobacterium tuberculosis Rv2801c, and Rv0659c.	X2BJU0,P64912,P64912	No	virulence, detoxification, adaptation			P64912					X2BJU0,P64912					Rv1991c		Rv1991c			
NC_002945.3	Mycobrowser_v4	CDS	2197216	2198436	.	-	0	Mb1998c	mce3r		probable transcriptional repressor (probably tetr-family) mce3r	Mb1998c, -, len: 406 aa. Equivalent to Rv1963c,len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable transcriptional regulatory protein, similar to several e.g. AL049485|SC6A5.30 Streptomyces coelicolor cosmid 6 A (404 aa), FASTA scores: opt: 319, E(): 6.4e-13, (29.5% identity in 373 aa overlap); and Z84498|MTCY9F9_1 (259 aa), FASTA scores: opt: 208, E(): 1.6e-07, (100.0% identity in 32 aa overlap). Contains probable helix-turn-helix at aa 36-57 (+4.23 SD).	Q7TZ70,A0A1R3XZU1	No	regulatory proteins			A0A1R3XZU1				IPR001647,IPR009057,IPR015893	Q7TZ70					Rv1963c		Rv1963c			
NC_002945.3	Mycobrowser_v4	CDS	2199335	2199739	.	+	0	Mb1999	yrbE3A		CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE3A	Mb1999, yrbE3A, len: 134 aa. Similar to 5' end of Rv1964, len: 265 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 102 aa overlap). yrbE3A,hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa), O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa),Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from Escherichia coli (260 aa), FASTA scores: opt: 893, E(): 0,(51.4% identity in 253 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of yrbE3A, the entire mce3 operon and the following genes up to Mb2000 compared to Mycobacterium tuberculosis strain H37Rv.	Q7TZ69,A0A1R3Y1Y6	No				A0A1R3Y1Y6					Q7TZ69										
NC_002945.3	Mycobrowser_v4	CDS	2202259	2202945	.	-	0	Mb2002c	mpt64		IMMUNOGENIC PROTEIN MPT64 (ANTIGEN MPT64/MPB64)	Mb2002c, -, len: 228 aa. Equivalent to Rv1980c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). mpt64 (alternate gene name: mpb64), immunogenic protein (alternate gene name: mpb64) (see citations below), identical to MPT64|MPB64 from Mycobacterium bovis (228 aa). Similar to Rv3036c|MTV012.51c from Mycobacterium tuberculosis. Exported protein containing a N-terminal signal sequence: see notes below about proteomics.	X2BJ68,P0A5Q5,P0A5Q5	No	cell wall and cell processes			P0A5Q5					X2BJ68,P0A5Q5					Rv1980c		Rv1980c			
NC_002945.3	Mycobrowser_v4	CDS	2203136	2204104	.	-	0	Mb2003c	nrdF1		RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF1 (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN)	Mb2003c, nrdF1, len: 322 aa. Equivalent to Rv1981c,len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 322 aa overlap). nrdF1,ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1) (see citation below), highly similar to others e.g. RIR4_SALTY|P17424 ribonucleoside-diphosphate reductase (319 aa), FASTA scores: opt: 1402, E(): 0,(66.0% identity in 315 aa overlap); etc. Also similar to Rv3048c|MTV012.63c from Mycobacterium tuberculosis. Contains PS00368 Ribonucleotide reductase small subunit signature. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. COFACTOR: BINDS 2 IRON IONS (BY SIMILARITY). Note that previously known as nrdF.	Q7TZ66,A0A1R3XZV2	No				A0A1R3XZV2				IPR000358,IPR009078,IPR012348,IPR026023,IPR026494	Q7TZ66										
NC_002945.3	Mycobrowser_v4	CDS	2204329	2204748	.	-	0	Mb2004c	vapc36		possible toxin vapc36. contains pin domain.	Mb2004c, -, len: 139 aa. Equivalent to Rv1982c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein. BELONGS TO THE UPF0110 FAMILY. Similar to Rv0624|Z92772|MTY20H10.05 from Mycobacterium tuberculosis (131 aa), FASTA scores: opt: 288, E(): 4.1e-14, (40.2% identity in 127 aa overlap); also similar to Rv0624, Rv2759c, and Rv0609	X2BJH4,P0A653,P0A653	No	virulence, detoxification, adaptation			P0A653					X2BJH4,P0A653					Rv1982c		Rv1982c			
NC_002945.3	Mycobrowser_v4	CDS	2204757	2205017	.	-	0	Mb2004A	vapB36		Possible antitoxin VapB36	Mb2004A, len: 86 aa. Equivalent to Rv1982A len: 86 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 86 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB36,antitoxin,part of toxin-antitoxin (TA) operon with Rv1982c, see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv0623, Rv2760c, Rv0608	X2BJT5,A0A1R3XZX5	No	virulence, detoxification, adaptation			A0A1R3XZX5					X2BJT5					Rv1982A		Rv1982A			
NC_002945.3	Mycobrowser_v4	CDS	2205160	2206836	.	+	0	Mb2005	PE_PGRS35		pe-pgrs family protein pe_pgrs35	Mb2005, PE_PGRS35, len: 558 aa. Equivalent to Rv1983, len: 558 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 558 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site.	Q7TZ65,A0A1R3XZU6	No				A0A1R3XZU6				IPR000084	Q7TZ65										
NC_002945.3	Mycobrowser_v4	CDS	2206824	2207477	.	-	0	Mb2006c	cfp21		PROBABLE CUTINASE PRECURSOR CFP21	Mb2006c, cfp21, len: 217 aa. Equivalent to Rv1984c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). cfp21, probable cutinase precursor with N-terminal signal sequence (EC 3.1.1.-), similar to P41744|CUTI_ALTBR cutinase precursor from Alternaria brassicicola (209 aa), FASTA scores: opt: 283, E(): 2.2e-11, (32.6% identity in 193 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Rv3452, Rv3451, Rv2301, Rv1758, Rv3724. BELONGS TO THE CUTINASE FAMILY.	X2BJ73,P63880,P63880	No				P63880					X2BJ73,P63880										
NC_002945.3	Mycobrowser_v4	CDS	2213559	2213807	.	-	0	Mb2014A	mazE6		Antitoxin MazE6	Mb2014A, len: 82 aa. Equivalent to Rv1991A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 82 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). MazE6, antitoxin, part of toxin-antitoxin (TA) operon with Rv1991c. Similar to ChpI of L. interrogans, FASTA scores: opt: 134, E(): 0.024,29.762% identity (65.476% similar) in 84 aa overlap. Note that Pandey and Gerdes, 2005 predicts a different N-terminus, adding 10 amino acids.	X2BJQ6,P0CL58,P0CL58	No	virulence, detoxification, adaptation			P0CL58					X2BJQ6,P0CL58					Rv1991A		Rv1991A			
NC_002945.3	Mycobrowser_v4	CDS	2210596	2211135	.	+	0	Mb2010	erm(37)		probable 23s rrna methyltransferase erm(37)	Mb2010, -, len: 179 aa. Equivalent to Rv1988, len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 179 aa overlap). Probable methyltransferase (EC 2.1.1.-), similar to ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 aa), FASTA scores: opt: 259, E(): 2e-11, (35.1% identity in 171 aa overlap); contains PS00092 N-6 Adenine-specific DNA methylases signature. Also similar to Mycobacterium tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase.	Q7TZ64,A0A1R3XZX2	No	intermediary metabolism and respiration			A0A1R3XZX2				IPR001737,IPR020598	Q7TZ64					Rv1988		Rv1988			
NC_002945.3	Mycobrowser_v4	CDS	2219075	2221792	.	+	0	Mb2020	ctpF		PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE A CTPF	Mb2020, ctpF, len: 905 aa. Equivalent to Rv1997,len: 905 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 905 aa overlap). Probable ctpF, metal cation-transporting P-type ATPase F (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. NP_250120.1|NC_002516 probable cation-transporting P-type ATPase from Pseudomonas aeruginosa (902 aa); NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (905 aa); NP_404093.1|NC_003143 putative cation-transporting P-type ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 2392, E(): 0, (46.5% identity in 852 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Was frame-shifted in original cosmid sequence.	X2BJ82,P63688,P63688	No	cell wall and cell processes			P63688					X2BJ82,P63688					Rv1997		Rv1997			
NC_002945.3	Mycobrowser_v4	CDS	2298000	2298266	.	-	0	Mb2081c	rpsR2		30s ribosomal protein s18 rpsr2	Mb2081c, rpsR2, len: 88 aa. Equivalent to Rv2055c,len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Probable rpsR2,ribosomal protein S18, similar to others e.g. RR18_ODOSI|P49505 chloroplast 30S ribosomal protein S18 (72 aa), FASTA scores: opt: 209, E(): 4.7e-09, (51.6% identity in 64 aa overlap); etc. Also similar to rpsR|Rv0055|MTCY21D4.18 from Mycobacterium tuberculosis (50.0% identity in 84 aa overlap).	X2BJZ9,P66466,P66466	No				P66466					X2BJZ9,P66466										
NC_002945.3	Mycobrowser_v4	CDS	2226576	2227358	.	+	0	Mb2025	fabG3		POSSIBLE 20-BETA-HYDROXYSTEROID DEHYDROGENASE FABG3 (Cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	Mb2025, fabG3, len: 260 aa. Equivalent to Rv2002,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Possible fabG3,20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53),similar to e.g. 2BHD_STREX|P19992 20-beta-hydroxysteroid dehydrogenase (255 aa), FASTA scores: opt: 718, E(): 2e-38, (49.8% identity in 243 aa overlap), and many mycobacterial proteins. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	X2BJ87,P69166,P69166	No				P69166					X2BJ87,P69166										
NC_002945.3	Mycobrowser_v4	CDS	2230918	2234901	.	+	0	Mb2029	otsB1		PROBABLE TREHALOSE-6-PHOSPHATE PHOSPHATASE OTSB1 (TREHALOSE-PHOSPHATASE) (TPP)	Mb2029, otsB1, len: 1327 aa. Equivalent to Rv2006,len: 1327 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1327 aa overlap). Probable otsB1, trehalose-6-phosphate phosphatase (EC 3.1.3.12) (see citations below); strong similarity in central domain to OTSB_ECOLI P31678 trehalose-phosphatase (266 aa) and M. leprae TREHALOSE-PHOSPHATASE Q49734 (429 aa). Belongs to Glycosyl hydrolases family 65 (http://www.expasy.ch/cgi-bin/lists?glycosid.txt). FASTA scores, sp|Q49734|Q49734 PUTATIVE TREHALOSE-PHOSPHATASE (429 aa) opt: 1283 E(): 0; 51.7% identity in 420 aa overlap opt: 278, E(): 3.6e-11, (29.4% identity in 255 aa overlap). Note that previously known as otsB.	Q7TZ61,A0A1R3XZZ3	No				A0A1R3XZZ3				IPR003337,IPR005194,IPR005195,IPR005196,IPR006379,IPR008928,IPR011013,IPR012341,IPR023214	Q7TZ61										
NC_002945.3	Mycobrowser_v4	CDS	2236946	2237188	.	+	0	Mb2032	vapb15		antitoxin vapb15	Mb2032, -, len: 80 aa. Equivalent to Rv2009, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 80 aa overlap). Conserved hypothetical protein, very similar to Rv1560|MTCY48.05c (54.4% identity in 68 aa overlap).	Q7TZ60,A0A1R3Y019	No	virulence, detoxification, adaptation			A0A1R3Y019				IPR019239	Q7TZ60					Rv2009		Rv2009			
NC_002945.3	Mycobrowser_v4	CDS	2237189	2237587	.	+	0	Mb2033	vapc15		toxin vapc15	Mb2033, -, len: 132 aa. Equivalent to Rv2010, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Conserved hypothetical protein, similar to Rv1561|MTCY48.04c, (38.1% identity in 126 aa overlap)	X2BJV0,P64926,P64926	No	virulence, detoxification, adaptation			P64926					X2BJV0,P64926					Rv2010		Rv2010			
NC_002945.3	Mycobrowser_v4	CDS	2256701	2258422	.	-	0	Mb2052c	dost		two component sensor histidine kinase dost	Mb2052c, -, len: 573 aa. Equivalent to Rv2027c,len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 573 aa overlap). Membrane protein related to histidine kinase response regulators. Highly similar to Mycobacterium tuberculosis protein Rv3132c,MTCY03A2.2 6. FASTA scores: Z83867|MTCY3A2_26 (578 aa) opt: 2330, E(): 0; 62.5% identity in 560 aa overlap.	Q7VET1,A0A1R3Y037	No	regulatory proteins			A0A1R3Y037				IPR003018,IPR003594,IPR011712	Q7VET1					Rv2027c		Rv2027c			
NC_002945.3	Mycobrowser_v4	CDS	2259319	2260338	.	-	0	Mb2054c	pfkB		6-phosphofructokinase pfkb (phosphohexokinase) (phosphofructokinase)	Mb2054c, pfkB, len: 339 aa. Equivalent to Rv2029c,len: 339 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 339 aa overlap). Probable pfkB,phosphofructokinase (EC 2.7.1.-), similar to others eg P06999|K6P2_ECOLI 6-PHOSPHOFRUCTOKINASE I SOZYME 2 from E. coli (309 aa), FASTA scores: opt: 705, E(): 0; (41.4% identity in 304 aa overlap); and LACC_STRMU phosphotagatosekinase (310 aa); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1.	Q7TZ43,A0A1R3XZZ1	No				A0A1R3XZZ1				IPR002173,IPR011611,IPR017583	Q7TZ43										
NC_002945.3	Mycobrowser_v4	CDS	2273598	2275133	.	-	0	Mb2071c	lipT		carboxylesterase lipt	Mb2071c, lipT, len: 511 aa. Equivalent to Rv2045c,len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable lipT,carboxylesterase similar to many e.g. O08472 (489 aa) and P37967|PNBA_ BACSU (489 aa). PARA-NITROBENZYL ESTERASE (EC 3.1.1.-). Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site. FASTA scores: sptr|O08472|O08472 INTRACELLULAR ESTERASE B (489 aa) opt: 849, E(): 0, (36.2% identity in 489 aa overlap) and sp|P37967|PNBA_BACSU PARA-NITROBENZYL ESTERASE (489 aa) opt: 838, E(): 0,(36.0% identity in 489 aa overlap). TBparse score is 0 .918	Q7VES4,A0A1R3Y007	No				A0A1R3Y007				IPR002018,IPR002168,IPR019819,IPR019826	Q7VES4										
NC_002945.3	Mycobrowser_v4	CDS	2298738	2298974	.	-	0	Mb2084c	rpmB2		50s ribosomal protein l28 rpmb2	Mb2084c, rpmB2, len: 78 aa. Equivalent to Rv2058c,len: 78 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 78 aa overlap). Probable rpmB2,ribosomal protein L28, very similar to rL28 of M. tuberculosis. FASTA results: RL28_MYCTU Q10879 50S ribosomal protein L28. mycobacter (94 aa) opt: 338; E(): 9.8e-19; 64.9% identity in 77 aa overlap. Also similar to rpmB (Rv0105c) of Mycobacterium tuberculosis.	X2BJX7,P66149,P66149	No				P66149					X2BJX7,P66149										
NC_002945.3	Mycobrowser_v4	CDS	2262411	2262845	.	-	0	Mb2057c	hspX		heat shock protein hspx (alpha-crystallin homolog) (14 kda antigen) (hsp16.3)	Mb2057c, hspX, len: 144 aa. Equivalent to Rv2031c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). hspX, heat shock protein localized in the inner membrane (see citations below). Identical to P30223|14KD_MYCTU 14 KD ANTIGEN (16 kDa ANTIGEN) (HSP 16.3) of Mycobacterium tuberculosis (143 aa), FASTA scores: opt: 933, E(): 0, (100.0% identity in 143 aa overlap). BELONGS TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY. Also known as alpha-crystallin and gene as acr (see some citations below). TBparse score is 0.897.	X2BJK6,P0A5B8,P0A5B8	No				P0A5B8					X2BJK6,P0A5B8										
NC_002945.3	Mycobrowser_v4	CDS	2263042	2264037	.	+	0	Mb2058	acg		conserved protein acg	Mb2058, -, len: 331 aa. Equivalent to Rv2032, len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 331 aa overlap). acg (for acr-coregulated gene), conserved hypothetical protein possibly member of a superfamily of classical nitroreductases (see first citation below), similar to hypothetical mycobacterial proteins Rv3127|MTCY164.37 (344 aa) and Rv3131|MTCY03A2.27c (332 aa). FASTA scores: Z95150|MTCY164_38 Mycobacterium tuberculosis cosmid (344 aa) opt: 1208, E(): 0, (56.4% identity in 321 aa overlap); Z83867| MTCY3A2_27 Mycobacterium tuberculosis cosmid (332 aa) opt: 568, E(): 8.6e-30, (36.8% identity in 321 aa overlap). Similar to proteins SCJ1.11 (330 aa; AL109962) and SCJ12.27c (335 aa; AL109989) in Streptomyces coelicolor.	Q7VET0,A0A1R3Y0T1	No	conserved hypotheticals			A0A1R3Y0T1				IPR000415	Q7VET0					Rv2032		Rv2032			
NC_002945.3	Mycobrowser_v4	CDS	2272594	2273154	.	-	0	Mb2069c	pncA		pyrazinamidase/nicotinamidase pnca (pzase)	Mb2069c, pncA, len: 186 aa. Equivalent to Rv2043c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 186 aa overlap). pncA,pyrazinamidase/nicotinamidase (EC 3.5.1.-) (see citations below). Identical to PYRAZINAMIDASE/NICOTINAMIDASE involved in susceptibility or resistance to antituberculous drug pyrazinamide. FASTA scores: sptr|Q50575|Q50575 PYRAZINAMIDASE/NICOTINAMIDASE. (186 aa) opt: 1236, E(): 0; 100.0% identity in 186 aa overlap.	I3NIF8,A0A1R3Y026	No				A0A1R3Y026				IPR000868	I3NIF8										
NC_002945.3	Mycobrowser_v4	CDS	2278444	2290899	.	-	0	Mb2074c	pks12		polyketide synthase pks12	Mb2074c, pks12, len: 4151 aa. Equivalent to Rv2048c, len: 4151 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 4151 aa overlap). Probable pks12, polyketide synthase similar to many polyketide synthases e.g. the second and third modules of polyketide synthase from S. erythraea (3567 aa), many other Streptomyces enzymes and putative Mycobacterium tuberculosis polyketide synthases, e.g. Z85982|MTCY06H11.26 (2126 aa), FASTA scores: opt: 6668,E(): 0 (61.2% identity in 2058 aa overlap); and Q03132|ERY2_SACER ERYTHRONOLIDE SYNTHASE, MODULES 3 from S. erythraea (3567 aa), FASTA scores: opt: 5309, E(): 0,(40.5% identity in 4141 aa overlap). Contains 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 Beta-ketoacyl synthases active site, and PS00343 Gram-positive cocci surface proteins 'anchor ing' hexapeptide.	Q7VES2,A0A1R3Y009	No	lipid metabolism			A0A1R3Y009				IPR001227,IPR006162,IPR009081,IPR011032,IPR013149,IPR013154,IPR013968,IPR014030,IPR014031,IPR014043,IPR016035,IPR016036,IPR016038,IPR016039,IPR016040,IPR018201,IPR020801,IPR020806,IPR020807,IPR020841,IPR020842,IPR020843	Q7VES2					Rv2048c		Rv2048c			
NC_002945.3	Mycobrowser_v4	CDS	2296435	2296962	.	-	0	Mb2079c	fxsa		probable transmembrane protein fxsa	Mb2079c, -, len: 175 aa. Equivalent to Rv2053c,len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Probable transmembrane protein	Q7VES0,A0A1R3Y030	No	cell wall and cell processes			A0A1R3Y030				IPR007313	Q7VES0					Rv2053c		Rv2053c			
NC_002945.3	Mycobrowser_v4	CDS	2346368	2346622	.	-	0	Mb2130c	vapb37		possible antitoxin vapb37	Mb2130c, -, len: 84 aa. Equivalent to Rv2104c, len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Conserved hypothetical protein, similar to members of a family of hypothetical mycobacterial proteins including Rv2871, Rv1241, Rv2132,Rv3321c, Rv1113, Rv0657, Rv1560, etc. FASTA scores: sptr|Q49787|Q49787 B2126_C2_217 (97 aa) opt: 197, E(): 2e-07; 57.1% identity in 56 aa overlap and Z95388|MTCY270_36 Mycobacterium tuberculosis cosmid (76 aa ) opt: 142, E(): 0.0011; 41.8% identity in 55 aa overlap.	Q7TZ15,A0A1R3Y0M6	No	virulence, detoxification, adaptation			A0A1R3Y0M6					Q7TZ15					Rv2104c		Rv2104c			
NC_002945.3	Mycobrowser_v4	CDS	2301082	2304666	.	-	0	Mb2088c	cobN		cobalamin biosynthesis protein cobn	Mb2088c, cobN, len: 1194 aa. Equivalent to Rv2062c,len: 1194 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1194 aa overlap). Probable cobN,cobalamin biosynthesis protein - very similar to COBN_PSEDE P29929 cobn protein. Pseudomonas denitrifica (1275 aa), FASTA scores, opt: 831, E(): 0, (37.5% identity in 983 aa overlap). Also similar to several Mg2+-chelatases e.g. H64479 magnesium chelatase subunit homolog (1226 aa )opt: 962 E(): 0; (27.3% identity in 846 aa overlap)	Q7VER8,A0A1R3Y298	No				A0A1R3Y298				IPR003672,IPR011953	Q7VER8										
NC_002945.3	Mycobrowser_v4	CDS	2304744	2304977	.	+	0	Mb2089	maze7		antitoxin maze7	Mb2089, -, len: 77 aa. Equivalent to Rv2063, len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Conserved hypothetical protein, showing some similarity to other conserved hypothetical proteins e.g. AL109974_2|SCF34.02c hypothetical protein from Streptomyces coelicolor (133 aa), FASTA scores: opt: 102, E(): 1.7, (34.35% identity in 67 aa overlap); and AE005182_1 from Escherichia coli strain O157:H7 (77 aa), FASTA scores: opt: 95, E(): 3.3,(34.85% identity in 66 aa overlap). This ORF replaces previous Rv2063c on other strand.	Q7TZ28,A0A1R3Y0V7	No	virulence, detoxification, adaptation			A0A1R3Y0V7				IPR002145	Q7TZ28					Rv2063		Rv2063			
NC_002945.3	Mycobrowser_v4	CDS	2304970	2305380	.	+	0	Mb2089A	mazF7		Possible toxin MazF7	Mb2089A, len: 136 aa. Equivalent to Rv2063A len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazF7 toxin, part of toxin-antitoxin (TA) operon with Rv2063 (See Pandey and Gerdes, 2005).	X2BJD2,A0A1R3Y048	No	virulence, detoxification, adaptation			A0A1R3Y048					X2BJD2					Rv2063A		Rv2063A			
NC_002945.3	Mycobrowser_v4	CDS	2305364	2306455	.	+	0	Mb2090	cobG		precorrin-3b synthase cobg	Mb2090, cobG, len: 363 aa. Equivalent to Rv2064,len: 363 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 363 aa overlap). Possible cobG,cobalamin biosynthesis protein. Some similarity to COBG_PSEDE P21637 cobg protein. pseudomonas (459 aa) FASTA scores, opt: 240, E(): 1.3e-08, (27.5% identity in 407 aa overlap); contains PS01156 TonB-dependent receptor proteins signature 2	Q7VER7,A0A1R3Y0G9	No	intermediary metabolism and respiration			A0A1R3Y0G9				IPR005117,IPR012798	Q7VER7					Rv2064		Rv2064			
NC_002945.3	Mycobrowser_v4	CDS	2306465	2307091	.	+	0	Mb2091	cobH		precorrin-8x methylmutase cobh (aka precorrin isomerase)	Mb2091, cobH, len: 208 aa. Equivalent to Rv2065,len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 208 aa overlap). Probable cobH,precorrin-8X methylmutase (aka precorrin isomerase) (EC 5.4.1.2), similar to COBH_PSEDE P21638 precorrin isomerase (210 aa), FASTA scores: opt: 750, E(): 0, (55.4% identity in 202 aa overlap).	X2BJM5,P63840,P63840	No	intermediary metabolism and respiration			P63840					X2BJM5,P63840					Rv2065		Rv2065			
NC_002945.3	Mycobrowser_v4	CDS	2307088	2308614	.	+	0	Mb2092	cobI		Probable bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase	Mb2092, cobI, len: 508 aa. Equivalent to Rv2066,len: 508 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 508 aa overlap). Probable CobI-CobJ fusion protein, S-adenosyl-L-methionine-precorrin-2 methyl transferase and precorrin-3 methylase (EC 2.1.1.-). Similar in N-terminal half (aa 1-240) to COBI_PSEDE|P21639, S-adenosyl-L-methionine-precorrin-2 methyl transferase (244 aa), FASTA scores: opt: 759, E(): 4.4e-34, (49.2% identity in 238 aa overlap); and in C-terminal half (aa 240-508) to P21640|COBJ_PSEDE PRECORRIN-3 METHYLASE (EC 2.1.1.-) (254 aa), FASTA scores: opt: 695, E(): 0, (45.3% identity in 258 aa overlap).	X2BJX9,P66878,P66878	No	intermediary metabolism and respiration			P66878					X2BJX9,P66878					Rv2066		Rv2066			
NC_002945.3	Mycobrowser_v4	CDS	2309799	2310722	.	-	0	Mb2094c	blaC		CLASS A BETA-LACTAMASE BLAC	Mb2094c, blaC, len: 307 aa. Equivalent to Rv2068c,len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 307 aa overlap). blaC, class A beta-lactamase (EC 3.5.2.6) (see citation below), similar to e.g. BLAC_NOCLA Q06316 beta-lactamase precursor (302 aa), FASTA scores, opt: 860, E(): 0, (50.2% identity in 283 aa overlap); eyc. Contains PS00013 Prokaryotic lipid attachment site near N-terminus, and PS00146 Beta-lactamase class-A active site. BELONGS TO THE CLASS-C BETA-LACTAMASE FAMILY.	X2BJD5,P0A5I7,P0A5I7	No				P0A5I7					X2BJD5,P0A5I7										
NC_002945.3	Mycobrowser_v4	CDS	2310857	2311414	.	+	0	Mb2095	sigC		rna polymerase sigma factor, ecf subfamily,sigc	Mb2095, sigC, len: 185 aa. Equivalent to Rv2069,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Probable sigC, RNA polymerase sigma factor (see citation below), with similarity to SIGX_BACSU|P35165 probable RNA polymerase sigma factor from Bacillus subtilis (194 aa), FASTA scores: opt: 218, E(): 4.1e-07, (32.6% identity in 129 aa overlap). Belongs to ECF subfamily.	X2BK16,P66810,P66810	No	information pathways			P66810					X2BK16,P66810					Rv2069		Rv2069			
NC_002945.3	Mycobrowser_v4	CDS	2311404	2312099	.	-	0	Mb2096c	cobK		precorrin-6x reductase cobk	Mb2096c, cobK, len: 231 aa. Similar to Rv2070c,len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 227 aa overlap). Probable cobK,precorrin-6x reductase (EC 1.3.1.54), similar to e.g. L21196|g347169|RERCOBLMK3 RERCOBLMKN from Rhodococcus sp. NI86/21 (248 aa), FASTA scores: opt: 792, E(): 0, (53.6% identity in 250 aa overlap). Also similarity to CBIJ_SALTY|Q05591 cbij protein from Salmonella typhimurium (263 aa), FASTA scores: opt: 166, E(): 9e-0 5, (26.7% identity in 258 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-a) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (231 aa versus 244 aa).	Q7VER6,A0A1R3Y042	No				A0A1R3Y042				IPR003723	Q7VER6										
NC_002945.3	Mycobrowser_v4	CDS	2312136	2312891	.	-	0	Mb2097c	cobM		precorrin-3 methylase cobm (precorrin-4 c11-methyltransferase)	Mb2097c, cobM, len: 251 aa. Equivalent to Rv2071c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Probable cobM,precorrin-3 methylase (EC 2.1.1.133), similar to e.g. L21196|g347169|RERCOBLMK2 RERCOBLMK from Rhodococococcus sp. NI86/21 (249 aa), FASTA scores: opt: 992, E(): 0,(62.4% identity in 245 aa overlap) and to COBM_ PSEDE|P21922 precorrin-3 methylase (253 aa), FASTA scores: opt: 863, E(): 0, (54.6% identity in 249 aa overlap). Contains PS00839 Uroporphyrin-III C-methyltransferase signature 1, and PS00840 Uroporphyrin-III C-methyltransferase signature 2.	Q7VER5,A0A1R3Y2A3	No				A0A1R3Y2A3				IPR000878,IPR003043,IPR006362,IPR014776,IPR014777	Q7VER5										
NC_002945.3	Mycobrowser_v4	CDS	2312888	2313772	.	-	0	Mb2098c	cobLb		Probable precorrin-6y methyltransferase CobLb [SECOND PART]	Mb2098c, cobLb, len: 294 aa. Equivalent to 3' end of Rv2072c, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 294 aa overlap). Probable cobL, methyl transferase (EC 2.1.1.132), similar to L21196|g347169|RERCOBLMK1 from Rhodocococcus sp. NI86/21 (447 aa), FASTA scores: opt: 892; E(): 0; (50.1% identity in 369 aa overlap), and to COBL_PSEDE|P21921 precorrin-6y methylase (413 aa), FASTA scores: opt: 830, E(): 0, (40.6% identity in 404 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 2029 bp deletion (H37Rv2.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb.	Q7VER4,A0A1R3Y0W7	No				A0A1R3Y0W7				IPR000878,IPR014008,IPR014776	Q7VER4										
NC_002945.3	Mycobrowser_v4	CDS	2313714	2313902	.	-	0	Mb2099c	cobLa		Probable precorrin-6y methyltransferase CobLa [FIRST PART]	Mb2099c, cobLa, len: 62 aa. Similar to 5' end of Rv2072c, len: 390 aa, from Mycobacterium tuberculosis strain H37Rv, (97.727% identity in 44 aa overlap). Probable cobL, methyl transferase (EC 2.1.1.132), similar to L21196|g347169|RERCOBLMK1 from Rhodocococcus sp. NI86/21 (447 aa), FASTA scores: opt: 892; E(): 0; (50.1% identity in 369 aa overlap), and to COBL_PSEDE|P21921 precorrin-6y methylase (413 aa), FASTA scores: opt: 830,E(): 0, (40.6% identity in 404 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 2029 bp (H37Rv2.2330073-2332101-*) (RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb.	Q7VER3,A0A1R3Y058	No				A0A1R3Y058				IPR000878,IPR014777	Q7VER3										
NC_002945.3	Mycobrowser_v4	CDS	2319192	2319755	.	+	0	Mb2106	lppJ		lipoprotein lppj	Mb2106, lppJ, len: 187 aa. Equivalent to Rv2080,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Possible lppJ,lipoprotein; contains prokayotic lipoprotein modification site (PS00013) and signal sequence at N-terminus.	X2BJN3,Q7VER1,Q7VER1	No	cell wall and cell processes			Q7VER1					X2BJN3,Q7VER1					Rv2080		Rv2080			
NC_002945.3	Mycobrowser_v4	CDS	2347842	2348138	.	+	0	Mb2131	PE22		pe family protein pe22	Mb2131, PE22, len: 98 aa. Equivalent to Rv2107,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Member of mycobacterial PE family e.g. Y03A_MYCTU Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores; opt: 214 E(): 1.3e-14, 39.8% identity in 93 aa overlap	Q7VEQ9,A0A1R3Y062	No	PE/PPE			A0A1R3Y062				IPR000084	Q7VEQ9					Rv2107		Rv2107			
NC_002945.3	Mycobrowser_v4	CDS	2326311	2328080	.	+	0	Mb2115	pknJ		transmembrane serine/threonine-protein kinase j pknj (protein kinase j) (stpk j)	Mb2115, pknJ, len: 589 aa. Equivalent to Rv2088,len: 589 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 589 aa overlap). Probable pknJ,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to other serine/threonine-protein kinases e.g. PKWA_THECU|P49695 putative serine/threonine-protein kinase (742 aa), FASTA scores: opt: 457, E(): 2.7e-15, (26.0% identity in 578 aa overlap); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation.	X2BK37,P65733,P65733	No	regulatory proteins			P65733					X2BK37,P65733					Rv2088		Rv2088			
NC_002945.3	Mycobrowser_v4	CDS	2348194	2348925	.	+	0	Mb2132	PPE36		ppe family protein ppe36	Mb2132, PPE36, len: 243 aa. Equivalent to Rv2108,len: 243 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 243 aa overlap). N-terminus is similar to N-terminal region of Mycobacterium tuberculosis PPE family proteins eg. YX23_MYCTU Q10813 hypothetical 41.1 kd protein cy274.23 (404 aa), FASTA scores; opt: 431, E(): 3.9e-32, 44.0% identity in 166 aa overlap	Q7VEQ8,A0A1R3Y0A7	No				A0A1R3Y0A7				IPR000030	Q7VEQ8										
NC_002945.3	Mycobrowser_v4	CDS	2328097	2329224	.	-	0	Mb2116c	pepE		dipeptidase pepe	Mb2116c, pepE, len: 375 aa. Equivalent to Rv2089c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Probable pepE,dipeptidase, similar to e.g. PEPQ_LACDL P46545, xaa-pro dipeptidase (368 aa), FASTA scores, opt: 617, E(): 5.1 e-32, (34.7% identity in 363 aa overlap); contains PS00491 Aminopeptidase P and proline dipeptidase signature. Also similar to Mycobacterium tuberculosis peptidases Rv2861c,Rv0734, Rv2535c.	X2BJP1,P65811,P65811	No				P65811					X2BJP1,P65811										
NC_002945.3	Mycobrowser_v4	CDS	2379118	2380191	.	+	0	Mb2163	pyrD		probable dihydroorotate dehydrogenase pyrd	Mb2163, pyrD, len: 357 aa. Equivalent to Rv2139,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). Probable pyrD,dihydroorotate dehydrogenase (EC 1.3.3.1); contains dihydroorotate dehydrogenase signatures 1 and 2 (PS00911,PS00912). FASTA best: PYRD_MYCLE P46727 dihydroorotate dehydrogenase (309 aa) opt: 1653, E(): 0; (82.6% identity in 304 aa overlap)	X2BK73,P65909,P65909	No	intermediary metabolism and respiration			P65909					X2BK73,P65909					Rv2139		Rv2139			
NC_002945.3	Mycobrowser_v4	CDS	2331177	2333897	.	-	0	Mb2119c	helY		atp-dependent dna helicase hely	Mb2119c, helY, len: 906 aa. Equivalent to Rv2092c,len: 906 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 906 aa overlap). Probable helY, DNA helicase (EC 3.6.1.-), with similarity to YJF0_YEAST P47047 hypothetical helicase in tdh1-gyp6 intergenic region, (1073 aa), FASTA scores, opt: 1004, E(): 0, (29.0% identity in 970 aa o verlap); contains PS00017 ATP/GTP-binding site motif A, PS00402 Binding-protein-dependent transport systems inner membrane comp signature. BELONGS TO THE SKI2 SUBFAMILY OF HELICASES.	Q7TZ20,A0A1R3Y080	No				A0A1R3Y080				IPR001650,IPR011545,IPR012961,IPR014001,IPR027417	Q7TZ20										
NC_002945.3	Mycobrowser_v4	CDS	2484884	2485309	.	-	0	Mb2256A	vapC16		Possible toxin VapC16	Mb2256A, len: 141 aa. Equivalent to Rv2231A len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapC16, toxin, part of toxin-antitoxin (TA) operon with Rv2231B (See Pandey and Gerdes, 2005). Nucleotide position 2505919 in the genome sequence has been corrected, A:G resulting in A81A.	X2BKH1,A0A1R3Y1C4	No	virulence, detoxification, adaptation			A0A1R3Y1C4					X2BKH1					Rv2231A		Rv2231A			
NC_002945.3	Mycobrowser_v4	CDS	2333946	2334872	.	-	0	Mb2120c	tatC		sec-independent protein translocase transmembrane protein tatc	Mb2120c, tatC, len: 308 aa. Equivalent to Rv2093c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable tatC,transmembrane protein, component of twin-arginine translocation protein export system (see citation below for more information), equivalent to U00017|U00017_1 from Mycobacterium leprae (317 aa), FASTA scores: opt: 1722,E(): 0, (84.5% identity in 310 aa overlap). Similarity to others e.g. P27857|TATC_ECOLI|MTTB|B3839|Z5360|ECS4768 Sec-independent protein translocase protein from E. coli strain K12 and O157:H7 (258 aa), FASTA scores: opt: 344,E(): 6e-16, (32.5% identity in 265 aa overlap). BELONGS TO THE TATC FAMILY.	X2BK44,P66896,P66896	No				P66896					X2BK44,P66896										
NC_002945.3	Mycobrowser_v4	CDS	2334889	2335140	.	-	0	Mb2121c	tatA		sec-independent protein translocase membrane-bound protein tata	Mb2121c, tatA, len: 83 aa. Equivalent to Rv2094c,len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Probable tatA,membrane-bound protein, component of twin-arginine translocation protein export system (see citation below for more information), equivalent to U00017_2 from Mycobacterium leprae (88 aa), FASTA scores: opt: 392, E(): 2e-20, (68.2% identity in 88 aa overlap). Similarity to others e.g. P27856|O65938|TATA_ECOLI SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN from E. coli strains K12 and O157:H7 (261 aa), FASTA scores: opt: 111, E(): 0.25, (28.0 % identity in 75 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE TATA/E FAMILY.	X2BJP6,P66890,P66890	No				P66890					X2BJP6,P66890										
NC_002945.3	Mycobrowser_v4	CDS	2335208	2336158	.	-	0	Mb2122c	pafc		proteasome accessory factor c pafc	Mb2122c, -, len: 316 aa. Equivalent to Rv2095c,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 316 aa overlap). Conserved hypothetical protein. Highly similar to ML1330 P54075|YY35_MYCLE HYPOTHETICAL 27.0 KD PROTEIN (247 aa) opt: 1127 E(): 0,(78.4% identity in 227 aa overlap). Also similar to ORF11(1) of Rhodococcus erythropolis. FASTA score: Z82004|REZ820043 REZ82004 NID: g1666179 - Rhodococcus (326 aa) opt: 624 E(): 1.1e-30; (56.7% identity in 319 aa overlap). Contains possible helix-turn-helix motif at aa 25-46, ( +2.92 SD)	Q7TZ19,A0A1R3Y0A3	No	intermediary metabolism and respiration			A0A1R3Y0A3				IPR026881,IPR028349	Q7TZ19					Rv2095c		Rv2095c			
NC_002945.3	Mycobrowser_v4	CDS	2336155	2337153	.	-	0	Mb2123c	pafb		proteasome accessory factor b pafb	Mb2123c, -, len: 332 aa. Equivalent to Rv2096c,len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 332 aa overlap). Conserved hypothetical protein. Highly similar to ML1329,P54076|YY36_MYCLE HYPOTHETICAL 35.4 KD PROTEIN B21 (331 aa) opt: 1676 E(): 0; (80.2% identity in 329 aa overlap) and to ORF10(1) of Rhodococcus erythropolis,Z82004|REZ820042 REZ 82004 NID: g1666179 (330 aa) opt: 1232, E(): 0; 59.9% identity in 332 aa overlap	X2BK22,P64942	No	intermediary metabolism and respiration			P64942					X2BK22					Rv2096c		Rv2096c			
NC_002945.3	Mycobrowser_v4	CDS	3111224	3112441	.	-	0	Mb2872c	cysG		POSSIBLE MULTIFUNCTIONAL ENZYME SIROHEME SYNTHASE CYSG: UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN III METHYLASE) (SUMT) (UROPORPHYRINOGEN III METHYLASE) (UROM) + PRECORRIN-2 OXIDASE + FERROCHELATASE	Mb2872c, cysG, len: 405 aa. Equivalent to Rv2847c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Possible cysG,multifunctional enzyme, siroheme synthase containing uroporphyrin-iii c-methyltransferase (EC 2.1.1.107),precorrin-2 oxidase (EC 1.-.-.-) and ferrochelatase (EC 4.99.1.-). C-terminus highly similar to many uroporphyrin-iii c-methyltransferases e.g. Q51720|COBA UROPORPHYRINOGEN III METHYLTRANSFERASE from Propionibacterium freudenreichii (257 aa), FASTA scores: opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa overlap); Q9HMY4|UROM|VNG2331G S-ADENOSYL-L-METHIONINE:UROPORPHYRINOGEN III METHYLTRANSFERASE from Halobacterium sp. strain NRC-1 (246 aa), FASTA scores: opt: 704, E(): 3.1e-35, (49.4% identity in 245 aa overlap); P42437|NASF_BACSU|NASBE UROPORPHYRIN-III C-METHYLTRANSFERASE from Bacillus subtilis (483 aa), FASTA scores: opt: 610, E(): 2.4e-29,(42.1% identity in 240 aa overlap); etc. And highly similar over entire length to other proteins e.g. Q9L1C9|SCL11.09c UROPORPHYRINOGEN III METHYLTRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1481, E(): 5.6e-82, (58.45% identity in 409 aa overlap); Q9I0M7|CYSG|PA2611 SIROHEME SYNTHASE from Pseudomonas aeruginosa (465 aa), FASTA scores: opt: 609, E(): 2.7e-29,(34.7% identity in 444 aa overlap); P11098|CYSG_ECOLI|B3368|Z4729|ECS4219 SIROHEME SYNTHASE from Escherichia coli stains O157:H7 and K12 (457 aa),FASTA scores: opt: 543, E(): 9.1e-27, (31.3% identity in 450 aa overlap); etc. BELONGS TO A FAMILY THAT GROUPS SUMT, CYSG, CBIF/COBM AND CBIL/COBI. Note that previously known as cysG2.	Q7TXQ3,A0A1R3Y2D0	No				A0A1R3Y2D0				IPR000878,IPR006366,IPR006367,IPR012409,IPR014776,IPR014777,IPR016040	Q7TXQ3										
NC_002945.3	Mycobrowser_v4	CDS	2337162	2338520	.	-	0	Mb2124c	pafa		proteasome accessory factor a pafa	Mb2124c, -, len: 452 aa. Equivalent to Rv2097c,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 452 aa overlap). Conserved hypothetical protein. Similarity to YTH6_ RHOSO P43484 hypothetical protein in thcr 5' region (333 aa), FASTA scores opt: 738, E(): 0, (38.5% identity in 330 aa overlap). Also highly similar to Mycobacterium leprae protein ML1328, P54077|YY37_MYCLE HYPOTHETICAL 38.1 KD PROTEIN (336 aa) opt: 1985 E(): 0; (96.4% identity in 307 aa overlap)	X2BJF1,P64944,P64944	No	intermediary metabolism and respiration			P64944					X2BJF1,P64944					Rv2097c		Rv2097c			
NC_002945.3	Mycobrowser_v4	CDS	2338572	2340047	.	-	0	Mb2125c	pe21		pe-pgrs family protein pe_pgrs36	Mb2125c, PE_PGRS36, len: 491 aa. Equivalent to Rv2099c (PE21) and Rv2098c (PE_PGRS36), len: 58 aa and 433 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 58 aa overlap and 99.8% identity in 433 aa overlap). Rv2098c|PE_PGRS36: Member of Mycobacterium tuberculosis PE-family, PGRS sub-family. Frameshifted near N-terminus. Rv2099c|PE21: 5'-end of Rv2098c (MTCY49.38c),then frameshifts. Sequence has been checked, no errors found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (ggc-*).	X2BK49,P0A689	No				P0A689					X2BK49										
NC_002945.3	Mycobrowser_v4	CDS	2342081	2345122	.	+	0	Mb2127	helZ		PROBABLE HELICASE HELZ	Mb2127, helZ, len: 1013 aa. Equivalent to Rv2101,len: 1013 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1013 aa overlap). Probable helZ,helicase (EC 3.6.-.-), similar to many e.g. PCC6803|P74552|SLL1366 HELICASE OF THE SNF2/RAD54 FAMILY from Synechocystis sp. strain PCC 6803 (1039 aa), FASTA scores: opt: 2015, E(): 0, (38.4% identity in 1063 aa overlap); etc.	Q7TZ18,A0A1R3Y2C1	No				A0A1R3Y2C1				IPR000330,IPR001650,IPR014001,IPR022138,IPR027417	Q7TZ18										
NC_002945.3	Mycobrowser_v4	CDS	2345927	2346361	.	-	0	Mb2129c	vapc37		possible toxin vapc37. contains pin domain.	Mb2129c, -, len: 144 aa. Equivalent to Rv2103c,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Conserved hypothetical protein, similar to hypothetical mycobacterial proteins belonging to family, includes Rv0749, Rv0277c, Rv2530c, Rv3320c, Rv2494, Rv2872, Rv0617,Rv1242 etc. FASTA scores: sptr|Q49793|Q49793 B2126_C3_261 (97 aa) opt: 331, E(): 4.8e-18; 59.4% identity in 96 aa overlap and gp|Z74024|MTCY274_3 Mycobacterium tuberculosis cosmid (147 aa) opt: 234, E(): 1.2e-10; 34.8% identity in 141 aa overlap.	Q7TZ16,A0A1R3Y089	No	virulence, detoxification, adaptation			A0A1R3Y089				IPR002716,IPR006226,IPR022907	Q7TZ16					Rv2103c		Rv2103c			
NC_002945.3	Mycobrowser_v4	CDS	2349465	2350211	.	-	0	Mb2133c	prcA		proteasome alpha subunit prca; assembles with beta subunit prcb.	Mb2133c, prcA, len: 248 aa. Equivalent to Rv2109c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 248 aa overlap). prcA, proteasome alpha-type subunit 1, highly similar to TR:Q53080 (EMBL:U26421 ) proteasome alpha-type subunit 1 from Rhodococcus (259 aa), FASTA scores; opt: 1035, E(): 0,67.2% identity in 247 aa overlap.	X2BK34,Q7TZ14,Q7TZ14	No				Q7TZ14					X2BK34,Q7TZ14										
NC_002945.3	Mycobrowser_v4	CDS	2350208	2351083	.	-	0	Mb2134c	prcB		proteasome beta subunit prcb; assembles with alpha subunit prca.	Mb2134c, prcB, len: 291 aa. Equivalent to Rv2110c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). prcB, proteasome beta-type subunit 2, highly similar to eg. TR:Q53083 (EMBL:U264 22) proteasome beta-type subunit 2 from Rhodococcus (292 aa), FASTA scores; opt: 1103, E(): 0,64.5% identity in 262 aa overlap.	X2BJF5,Q7TZ13,Q7TZ13	No				Q7TZ13					X2BJF5,Q7TZ13										
NC_002945.3	Mycobrowser_v4	CDS	2351387	2352994	.	-	0	Mb2136c	dop		deamidase of pup dop	Mb2136c, -, len: 535 aa. Similar to Rv2112c, len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 532 aa overlap). Conserved hypothetical protein. Highly similar to a hypothetical protein TR:Q53081 (EMBL:U26422) (499 aa) upstream of Rhodococcus proteasome beta-type subunit 1, FASTA scores opt: 2832 E(): 0, 85.3% identity in 502 aa overlap. Also some similarity to Mycobacterium tuberculosis hypothetical protein Rv2097c (MTCY49.37c, 38.2% identity in 419 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa).	Q7TZ11,A0A1R3Y085	No				A0A1R3Y085				IPR004347,IPR022366	Q7TZ11										
NC_002945.3	Mycobrowser_v4	CDS	2354886	2356715	.	-	0	Mb2139c	mpa		mycobacterial proteasome atpase mpa	Mb2139c, -, len: 609 aa. Equivalent to Rv2115c,len: 609 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 609 aa overlap). Probable ATPase (EC 3.6.1.-), similar to e.g. YB56_METJA Q58556 cell division cycle protein 48 homolog (903 aa), FASTA scores; opt: 423,E(): 8.1e-32, 45.8% identity in 249 aa overlap. Contains PS00674 AAA-protein family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also some similarity to other Mycobacterium tuberculosis ATPases eg. Rv0435c and Rv3610c. Equivalent to Mycobacterium leprae U00 017|U00017_18 (609 aa), FASTA scores; opt: 3670 E(): 0; 92.9% identity in 609 aa overlap.	X2BJF7,P63346,P63346	No	cell wall and cell processes			P63346					X2BJF7,P63346					Rv2115c		Rv2115c			
NC_002945.3	Mycobrowser_v4	CDS	2356996	2357565	.	+	0	Mb2140	lppK		conserved lipoprotein lppk	Mb2140, lppK, len: 189 aa. Equivalent to Rv2116,len: 189 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 189 aa overlap). Probable lppK,conserved lipoprotein, similar to Mycobacterium leprae B2126_F3_115 TR:Q49803 (194 aa), FASTA scores; opt: 624,E(): 3.1e-31, 51.6% identity in 190 aa overlap. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to Rv2376c.	X2BK65,P65301,P65301	No	cell wall and cell processes			P65301					X2BK65,P65301					Rv2116		Rv2116			
NC_002945.3	Mycobrowser_v4	CDS	2360231	2361085	.	-	0	Mb2145c	hisG		atp phosphoribosyltransferase hisg	Mb2145c, hisG, len: 284 aa. Equivalent to Rv2121c,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). Probable hisG, ATP phosphoribosyltransferase (EC 2.4.2.17) (see citation below), similar to others e.g. HIS1_ECOLI|P10366 ATP phosphoribosyltransferase from Escherichia coli (299 aa),FASTA scores: opt: 351, E(): 4.5e-20, (31.8% identity in 289 aa overlap); etc.	X2BK72,P60760,P60760	No				P60760					X2BK72,P60760										
NC_002945.3	Mycobrowser_v4	CDS	2361088	2361369	.	-	0	Mb2146c	hisE		phosphoribosyl-amp pyrophosphatase hise	Mb2146c, hisE, len: 93 aa. Equivalent to Rv2122c,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable hisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (EC 3.6.1.31) (see citation below), similar to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): 4e-08, (37.9% identity in 87 aa overlap); etc. Note that previously misnamed hisI.	X2BJR8,P0A5B2,P0A5B2	No				P0A5B2					X2BJR8,P0A5B2										
NC_002945.3	Mycobrowser_v4	CDS	2361496	2362890	.	+	0	Mb2147	PPE37		ppe family protein ppe37	Mb2147, PPE37, len: 464 aa. Equivalent to Rv2123,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(97.9% identity in 473 aa overlap). PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa).	Q7VEQ6,A0A1R3Y2D4	No				A0A1R3Y2D4				IPR000030	Q7VEQ6										
NC_002945.3	Mycobrowser_v4	CDS	2362887	2366465	.	-	0	Mb2148c	metH		5-methyltetrahydrofolate--homocystein methyltransferase meth (methionine synthase, vitamin-b12 dependent isozyme) (ms)	Mb2148c, metH, len: 1192 aa. Equivalent to Rv2124c,len: 1192 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1192 aa overlap). Probable metH,methionine synthase (EC 2.1.1.13), similar to many e.g. METH_ECOLI|P13009 5-methyltetrahydrofolate--homocystein methyltransferase from Escherichia coli (1226 aa), FASTA scores: opt: 1446, E(): 0, (32.1% identity in 1223 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO THE VITAMIN-B12 DEPENDENT METHIONINE SYNTHASE FAMILY.	Q7VEQ5,A0A1R3Y112	No				A0A1R3Y112				IPR000489,IPR003726,IPR003759,IPR004223,IPR006158,IPR011005,IPR011822	Q7VEQ5										
NC_002945.3	Mycobrowser_v4	CDS	2367600	2368667	.	-	0	Mb2150c	PE_PGRS37		pe-pgrs family protein pe_pgrs37	Mb2150c, -, len: 256 aa. Equivalent to Rv2126c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 256 aa overlap). Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family e.g. MTCY441.04c (778 aa), FASTA scores; opt: 935, E(): 4.4e-18, 56.1% identity in 271 aa overlap	Q7VEL2,A0A1R3Y0P0	No	PE/PPE			A0A1R3Y0P0					Q7VEL2					Rv2126c		Rv2126c			
NC_002945.3	Mycobrowser_v4	CDS	2369014	2370483	.	+	0	Mb2151	ansP1		l-asparagine permease ansp1	Mb2151, ansP1, len: 489 aa. Equivalent to Rv2127,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 489 aa overlap). Probable ansP1,L-asparagine permease, integral membrane protein highly similar to many eg. ANSP_ECOLI P77610 L-asparagine permease (L-asparagine transport protein) (516 aa), FASTA scores: opt: 1880, E(): 0, (60.3% identity in 463 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis permeases Rv0346c|MTCY13E10.06c, (72.1% identity in 473 aa overlap) and Rv1704c|MTCI125.26c|cycA. Contains PS00218 Amino acid permeases signature. SEEMS TO BELONG TO THE APC FAMILY.	X2BJS3,Q7VEQ4,Q7VEQ4	No				Q7VEQ4					X2BJS3,Q7VEQ4										
NC_002945.3	Mycobrowser_v4	CDS	2380196	2380726	.	-	0	Mb2164c	TB18.6		conserved protein tb18.6	Mb2164c, TB18.6, len: 176 aa. Equivalent to Rv2140c, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 176 aa overlap). TB18.6,conserved hypothetical protein; shows good similarity to hypothetical proteins from Streptomyces coelicolor (177 aa; 58% identity) >emb|CAC32358.1| (AL583945) and to 17.1 kd Escherichia coli protein YbhB. FASTA best: YBHB_ECOLI P12994 hypothetical 17.1 kd protein (158 aa) opt: 465 E( ): 2e-23; (46.2% identity in 156 aa overlap).	X2BJH2,P67227	No	conserved hypotheticals			P67227					X2BJH2					Rv2140c		Rv2140c			
NC_002945.3	Mycobrowser_v4	CDS	2371613	2372857	.	-	0	Mb2154c	mshc		cysteine:1d-myo-inosityl 2-amino-2-deoxy--d-glucopyranoside ligase mshc	Mb2154c, cysS2, len: 414 aa. Equivalent to Rv2130c,len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 414 aa overlap). Probable cysS2,cysteinyl-tRNA synthetase, similar to many e.g. SYC_ECOLI|P21888 cysteinyl-tRNA synthetase from Escherichia coli (461 aa), FASTA scores: opt: 535, E(): 0,(37.0% identity in 370 aa overlap); etc. Also similar to Mycobacterium tuberculosis cysS|Rv3580c|MTCY06G11.27c,(35.8% identity in 372 aa overlap).	X2BJG6,P67018,P67018	No				P67018					X2BJG6,P67018										
NC_002945.3	Mycobrowser_v4	CDS	2372915	2373718	.	-	0	Mb2155c	cysQ		monophosphatase cysq	Mb2155c, cysQ, len: 267 aa. Equivalent to Rv2131c,len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 267 aa overlap). cysQ, equivalent to Mycobacterium leprae CYSQ_MYCLE P46726 cysQ protein homolog (289 aa). Contains inositol monophosphatase family signature 1 (PS00629), significance uncertain. FASTA best: CYSQ_MYCLE P4672 6 cysq protein homolog (289 aa) opt: 1374, E(): 0; (77.3% identity in 264 aa overlap)	X2BK83,P65164,P65164	No				P65164					X2BK83,P65164										
NC_002945.3	Mycobrowser_v4	CDS	2377728	2378804	.	+	0	Mb2162	lppL		Probable conserved lipoprotein LppL	Mb2162, lppL, len: 358 aa. Equivalent to Rv2138,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 358 aa overlap). Probable lppL,conserved lipoprotein, with appropriately placed lipoprotein signature (PS00013) strongly similar to hypothetical Mycobacterium leprae protein, Q49806. FASTA best: Q49806 B2126_F3_142. (298 aa) opt: 1495, E(): 0; (75.3% identity in 300 aa overlap).	Q7VEQ1,A0A1R3Y0D3	No	cell wall and cell processes			A0A1R3Y0D3				IPR011042	Q7VEQ1					Rv2138		Rv2138			
NC_002945.3	Mycobrowser_v4	tRNA	2382501	2382586	.	+	0	leuU	leuU		tRNA-Leu	leuU, len: 86 nt. Equivalent to leuU, len: 86 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 86 nt overlap). leu-tRNA, anticodon gag.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2382707	2383024	.	-	0	Mb2166c	pare2		possible toxin pare2	Mb2166c, -, len: 105 aa. Equivalent to Rv2142c,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). Hypothetical unknown protein.	Q7TYZ7,A0A1R3Y0A6	No	virulence, detoxification, adaptation			A0A1R3Y0A6				IPR007712	Q7TYZ7					Rv2142c		Rv2142c			
NC_002945.3	Mycobrowser_v4	CDS	2385130	2385912	.	-	0	Mb2169c	wag31		diviva family protein wag31	Mb2169c, wag31, len: 260 aa. Equivalent to Rv2145c,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). wag31 (alternate gene name: ag84). Function unknown but corresponds to antigen 84 of Mycobacterium tuberculosis (wag31) (see first citation below). Predicted to contain significant amount of coiled coil structure. Some similarity to Rv1682 and Rv2927c. FASTA best: AG84_MYCTU P46816 antigen 84.	X2BKA1,P0A5N3,P0A5N3	No				P0A5N3					X2BKA1,P0A5N3										
NC_002945.3	Mycobrowser_v4	CDS	2388136	2388888	.	-	0	Mb2173c	yfiH		conserved protein yfih	Mb2173c, yfiH, len: 250 aa. Equivalent to Rv2149c,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). yfiH; corresponds to hypothetical 25.3 kDa YfiH protein in ftsZ 3' region of Streptomyces griseus, and to YfiH proteins in other bacteria. Belongs to UPF0124 Family. FASTA best: YFIH_STRGR P45496, (246 aa) opt: 722, E(): 1.9e-37; (49.4% identity in 245 aa overlap)	X2BJI0,P67257	No				P67257					X2BJI0										
NC_002945.3	Mycobrowser_v4	CDS	2388899	2390038	.	-	0	Mb2174c	ftsZ		cell division protein FtsZ	Mb2174c, ftsZ, len: 379 aa. Equivalent to Rv2150c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). ftsZ, cell division protein (see first citation below). Contains FtsZ protein signature 2 (PS01135). FASTA best: FTSZ_STRCO P45500 cell division protein FtsZ (399 aa) opt: 1674, E(): 0; (77.3% identity in 339 aa overlap).	X2BKA6,P64171,P64171	No				P64171					X2BKA6,P64171										
NC_002945.3	Mycobrowser_v4	CDS	2390211	2391155	.	-	0	Mb2175c	ftsQ		POSSIBLE CELL DIVISION PROTEIN FTSQ	Mb2175c, ftsQ, len: 314 aa. Equivalent to Rv2151c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Possible ftsQ, cell division protein, with some homology to FTSQ_STRGR|P45503 cell division protein ftsq homolog from Streptomyces griseus (208 aa), FASTA scores: opt: 204, E(): 4e-05; (30.6% identity in 193 aa overlap).	X2BJV8,P64169,P64169	No				P64169					X2BJV8,P64169										
NC_002945.3	Mycobrowser_v4	CDS	2391152	2392636	.	-	0	Mb2176c	murC		probable udp-n-acetylmuramate-alanine ligase murc	Mb2176c, murC, len: 494 aa. Equivalent to Rv2152c,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 494 aa overlap). Probable murC,UDP-N-acetylmuramate-alanine ligase (EC 6.3.2.8). FASTA best: MURC_ECOLI P17952 (491 aa) opt: 764, E(): 0; (36.9% identity in 474 aa overlap)	X2BK24,P65473,P65473	No				P65473					X2BK24,P65473										
NC_002945.3	Mycobrowser_v4	CDS	2392633	2393865	.	-	0	Mb2177c	murG		probable upd-n-acetylglucosamine-n-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-n-acetylglucosamine transferase murg	Mb2177c, murG, len: 410 aa. Equivalent to Rv2153c,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 410 aa overlap). Probable MURG PROTEIN (UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase. FASTA score: MURG_BACSU P37585 murg protein (363 aa) opt: 494, E(): 1.1e-20; (27.9% identity in 365 aa overlap)	X2BK91,Q7VEP8,Q7VEP8	No				Q7VEP8					X2BK91,Q7VEP8										
NC_002945.3	Mycobrowser_v4	CDS	2393862	2395436	.	-	0	Mb2178c	ftsW		FtsW-like protein FtsW	Mb2178c, ftsW, len: 524 aa. Equivalent to Rv2154c,len: 524 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 524 aa overlap). Probable ftsW, cell division protein, related to MTCY10H4.17c, 3.2e-17. FASTA best: SP5E_BACSU P07373 stage V sporulation protein E (366 aa) opt: 755, E(): 1.6e-33; (38.4% identity in 357 aa overlap)	X2BJI2,P63763,P63763	No				P63763					X2BJI2,P63763										
NC_002945.3	Mycobrowser_v4	CDS	2395448	2396908	.	-	0	Mb2179c	murD		probable udp-n-acetylmuramoylalanine-d-glutamate ligase murd	Mb2179c, -, len: 486 aa. Equivalent to Rv2155c,len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 486 aa overlap). Probable murD,UDP-N-acetylmuramoylalanine-D-glutamate ligase (EC 6.3.2.9). FASTA best: MURD_BACSU Q03522 (451 aa) opt: 534,E(): 2.7e-25; (28.8% identity in 483 aa overlap); contains PS01011 Folylpolyglutamate synthase signature 1	X2BKB2,Q7VEP7,Q7VEP7	No	cell wall and cell processes			Q7VEP7					X2BKB2,Q7VEP7					Rv2155c		Rv2155c			
NC_002945.3	Mycobrowser_v4	CDS	2396910	2397989	.	-	0	Mb2180c	murX		probable phospho-n-acetylmuramoyl-pentappeptidetransferase murx	Mb2180c, murX, len: 359 aa. Equivalent to Rv2156c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable murX,phospho-N-acetylmuramoyl-pentappeptidetransferase (EC 2.7.8 .13). FASTA best: MRAY_ECOLI P15876 (360 aa) opt: 572 z-sco re: 651.6 E(): 2.7e-29; (35.8% identity in 344 aa overlap)	X2BJW5,P64260,P64260	No				P64260					X2BJW5,P64260										
NC_002945.3	Mycobrowser_v4	CDS	2397986	2399518	.	-	0	Mb2181c	murF		probable udp-n-acetylmuramoylalanyl-d-glutamyl-2,6-diaminopimelate-d-alanyl-d-alanyl ligase murf	Mb2181c, murF, len: 510 aa. Equivalent to Rv2157c,len: 510 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 510 aa overlap). Probable murF,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D -alanyl-D-alanyl ligase (EC 6.3.2.15) (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE) also related to other Mycobacterium tuberculosis mur gene products. FASTA best: MURF_ECOLI P11880 (452 aa) opt: 515, E(): 2.6e-24, (31.9% identity in 511 aa overlap); deleted EC number 6.3.2.15	X2BK26,P0A5L5,P0A5L5	No				P0A5L5					X2BK26,P0A5L5										
NC_002945.3	Mycobrowser_v4	CDS	2399515	2401122	.	-	0	Mb2182c	murE		Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE	Mb2182c, murE, len: 535 aa. Equivalent to Rv2158c,len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 535 aa overlap). Probable murE,UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (EC 6.3.2.13; UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE) also related to other Mycobacterium tuberculosis mur gene products. FASTA best: MURE_BACSU Q03523 (494 aa) opt: 1020 z- score: 1110.1 E(): 0; (40.1% identity in 476 aa overlap)	X2BK97,P65478,P65478	No				P65478					X2BK97,P65478										
NC_002945.3	Mycobrowser_v4	CDS	2403758	2405230	.	-	0	Mb2186c	PE_PGRS38		pe-pgrs family protein pe_pgrs38	Mb2186c, PE_PGRS38, len: 490 aa. Similar to Rv2162c, len: 532 aa, from Mycobacterium tuberculosis strain H37Rv, (92.105% identity in 532 aa overlap). Member of Mycobacterium tuberculosis PE_PGRS family. FASTA score: Y03A_MYCTU Q 10637 hypothetical glycine-rich 49.6 kd protein (603 aa) op t: 1798 z-score: 1220.0 E(): 0; (55.4% identity in 590 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa).	Q7VEP6,A0A1R3Y2H6	No				A0A1R3Y2H6				IPR000084	Q7VEP6										
NC_002945.3	Mycobrowser_v4	CDS	2405440	2407479	.	-	0	Mb2187c	pbpB		Probable penicillin-binding membrane protein pbpB	Mb2187c, pbpB, len: 679 aa. Equivalent to Rv2163c,len: 679 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 679 aa overlap). Probable pbpB,penicillin-binding membrane protein, similar to many bacterial PBP2 proteins e.g. P11882|PBP2_NEIME|PENA|NMA2072|NMB0413 penicillin-binding protein 2 (pbp-2) from Neisseria meningitidis (serogroups A and B) (581 aa), FASTA scores: opt: 665, E(): 1.6e-31,(33.2% identity in 591 aa overlap); etc. Also similar to Rv0016c and Rv2864c from Mycobacterium tuberculosis (2.8e-10). Contains PS00017 possible ATP/GTP-binding site motif A (P-loop) near C-terminus. FASTA best: PBP2_NEIME P11882 penicillin-binding protein 2 (pbp-2). (581 aa) opt: 665, E(): 1.6e-31; (33 .2% identity in 591 aa overlap)	Q7VEP5,A0A1R3Y155	No				A0A1R3Y155				IPR001460,IPR005311,IPR012338	Q7VEP5										
NC_002945.3	Mycobrowser_v4	CDS	2435934	2436545	.	+	0	Mb2216	ctaE		PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE	Mb2216, ctaE, len: 203 aa. Equivalent to Rv2193,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Probable ctaE,cytochrome c oxidase polypeptide III (cox3) (EC 1.9.3.1),with strong similarity to others e.g. COX3_SYNY3|Q06475 (29.8% identity in 225 aa overlap).	X2BK43,P63857,P63857	No	intermediary metabolism and respiration			P63857					X2BK43,P63857					Rv2193		Rv2193			
NC_002945.3	Mycobrowser_v4	CDS	2411985	2412668	.	+	0	Mb2193	lppM		Probable conserved lipoprotein lppM	Mb2193, lppM, len: 227 aa. Equivalent to Rv2171,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). Probable lppM,conserved lipoprotein; contains putative signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Has hydrophobic stretch at C-terminus and also contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. Unknown but equivalent to Mycobacterium leprae lipoprotein ML0902 (239 aa). FASTA scores: opt: 1083, E(): 2.4e-56; 75.446% identity in 224 aa overlap (5-227:16-239) >emb|CAA18680.1| (AL022602) >gi|13092972|emb|CAC31283.1| (AL583920).	Q7VEP4,A0A1R3Y0D8	No	cell wall and cell processes			A0A1R3Y0D8				IPR021499	Q7VEP4					Rv2171		Rv2171			
NC_002945.3	Mycobrowser_v4	CDS	2413881	2414939	.	+	0	Mb2195	idsA2		PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE)	Mb2195, idsA2, len: 352 aa. Equivalent to Rv2173,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Probable idsA2,geranylgeranyl pyrophosphate synthase (EC 2.5.1.-),similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Contains PS00723 and PS00444Polyprenyl synthetases signature 1 and 2. FASTA scores: sptr|Q54193|Q54193 GERANYLGERANYL PYROPHOSPHATE SYNTHASE (425 aa) opt: 744, E(): 0; 39.2% identity in 352 aa overlap.	Q7TYY7,A0A1R3Y0E9	No				A0A1R3Y0E9				IPR000092,IPR008949,IPR017446	Q7TYY7										
NC_002945.3	Mycobrowser_v4	CDS	2414943	2416493	.	+	0	Mb2196	mpta		alpha(1->6)mannosyltransferase. possible conserved integral membrane protein.	Mb2196, -, len: 516 aa. Equivalent to Rv2174, len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 516 aa overlap). Possible conserved integral membrane protein, similar to some hypothetical mycobacterial proteins e.g. Mycobacterium leprae ML0899 probable integral-membrane protein (505 aa) and MLCL536_26 (593 aa). FASTA scores: ML0899 opt: 2715; 78.884% identity in 502 aa overlap and gp|Z99125|MLCL536_26 Mycobacterium leprae cosmid L536. (593 aa) opt: 552, E(): 7.1e-30; 31.6% identity in 513 aa overlap. Also similar to Rv1459c.	Q7VEP3,A0A1R3Y2J0	No	cell wall and cell processes			A0A1R3Y2J0				IPR017822	Q7VEP3					Rv2174		Rv2174			
NC_002945.3	Mycobrowser_v4	CDS	2416975	2418174	.	+	0	Mb2198	pknL		PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	Mb2198, pknL, len: 399 aa. Equivalent to Rv2176,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 399 aa overlap). Probable pknL,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to many e.g. MLCB1770_9 (622 aa). Lacks C-terminal domain and ends with putative transmembrane segment. Contains PS00108 Serine/Threonine protein kinases active-site signature. FASTA scores: Z70722|MLC B1770_9 Mycobacterium leprae cosmid B1770 (622 aa) opt: 732, E(): 5.9e-23; 44.4% identity in 266 aa overlap. Also similar to several Mycobacterium tuberculosis STPK proteins e.g. Rv0014c|PKNB,Rv0015c|PKNA, Rv1743|PKNE, Rv1266c|PKNH etc. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.	X2BJJ4,Q7TYY6,Q7TYY6	No	regulatory proteins			Q7TYY6					X2BJJ4,Q7TYY6					Rv2176		Rv2176			
NC_002945.3	Mycobrowser_v4	CDS	2419366	2420754	.	-	0	Mb2200c	aroG		3-deoxy-d-arabino-heptulosonate 7-phosphate synthase arog (dahp synthetase,phenylalanine-repressible)	Mb2200c, aroG, len: 462 aa. Equivalent to Rv2178c,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 462 aa overlap). Probable aroG,3-deoxy-D-arabino-heptulosonate 7-phosphate synthase similar to many, especially those from plants. FASTA scores: Y15113|M C3DDAH7P_1Morinda citrifolia mRNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (535 aa) opt: 1421, E(): 0; 48.3% identity in 443 aa overlap.	Q7VEP1,A0A1R3Y0C5	No				A0A1R3Y0C5				IPR002480	Q7VEP1										
NC_002945.3	Mycobrowser_v4	CDS	2426100	2426534	.	-	0	Mb2207c	TB16.3		conserved protein tb16.3	Mb2207c, TB16.3, len: 144 aa. Equivalent to Rv2185c, len: 144 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 144 aa overlap). TB16.3,conserved hypothetical protein, similar to other hypothetical actinomycete proteins and equivalent to Mycobacterium leprae ML0889 (144 aa). Some similarity to Mycobacterium tuberculosis Rv0854, Rv0856, Rv0857, Rv0164 and other Mycobacterium leprae proteins. FASTA scores : ML0889 opt: 811; 85.417% identity in 144 aa overlap (AL022602).	Q7TYY1,A0A1R3Y175	No	conserved hypotheticals			A0A1R3Y175				IPR005031,IPR023393	Q7TYY1					Rv2185c		Rv2185c			
NC_002945.3	Mycobrowser_v4	CDS	2427194	2427706	.	+	0	Mb2209	fadd15		HYPOTHETICAL PROTEIN	Mb2209, -, len: 170 aa. Equivalent to 5' end of Rv2187, len: 600 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 90 aa overlap). Probable fadD15, long-chain-fatty-acid-CoA ligase (EC 6.2.1.3),similar to several e.g. P44446|LCFH_HAEIN PUTATIVE LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): 0, (31.5% identity in 578 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts, Mb2209 and fadD15.	Q7TYX9,UPI00001A90B9	No				UPI00001A90B9				IPR000873	Q7TYX9										
NC_002945.3	Mycobrowser_v4	CDS	2427469	2428995	.	+	0	Mb2210	fadD15		Probable long-chain-fatty-acid-CoA ligase fadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Mb2210, fadD15, len: 508 aa. Equivalent to 3' end of Rv2187, len: 600 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 508 aa overlap). Probable fadD15, long-chain-fatty-acid-CoA ligase (EC 6.2.1.3),similar to several e.g. P44446|LCFH_HAEIN PUTATIVE LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): 0, (31.5% identity in 578 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. TBparse score is 0.902. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to single base deletion (t-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	X2BK09,Q7TYX8,Q7TYX8	No				Q7TYX8					X2BK09,Q7TYX8										
NC_002945.3	Mycobrowser_v4	CDS	2437425	2438714	.	+	0	Mb2218	qcrA		Probable Rieske iron-sulfur protein QcrA	Mb2218, qcrA, len: 429 aa. Equivalent to Rv2195,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 429 aa overlap). Probable qcrA,Ubiquinol-cytochrome C reductase iron-sulfur subunit (cyoB), shows some similarity to cytochrome B6-F complex iron-sulphur subunits (Rieske iron-sulfur protein); contains PS00200 Rieske iron-sulfur protein signature 2	X2BJK9,Q7TYX4,Q7TYX4	No	intermediary metabolism and respiration			Q7TYX4					X2BJK9,Q7TYX4					Rv2195		Rv2195			
NC_002945.3	Mycobrowser_v4	CDS	2429026	2430183	.	-	0	Mb2211c	pimb		mannosyltransferase pimb	Mb2211c, -, len: 385 aa. Equivalent to Rv2188c,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 385 aa overlap). Conserved hypothetical protein, possibly glycosyl transferase similar to several putative glycosyl transferases and hypothetical proteins e.g. P73369. Equivalent to Mycobacterium leprae ML0886 putative glycosyl transferase (384 aa). FASTA scores: ML0886 (CAA18697.1| (AL022602) ) opt: 2113, E(): 1.8e-106; 81.462% identity in 383 aa overlap; sptr|P73369|P73369 HYPOTHETICAL 46.2 KD PROTEIN (404 aa) opt: 379, E(): 2.2e-18; 27.5% identity in 397 aa overlap. Start changed since first submission, now 14 aa shorter.	Q7TYX7,A0A1R3Y0H8	No	lipid metabolism			A0A1R3Y0H8				IPR001296	Q7TYX7					Rv2188c		Rv2188c			
NC_002945.3	Mycobrowser_v4	CDS	2436586	2437428	.	+	0	Mb2217	qcrC		Probable Ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit)	Mb2217, qcrC, len: 280 aa. Equivalent to Rv2194,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable qcrC,Ubiquinol-cytochrome C reductase cytochrome C subunit (cyoA), shows similarity to cytochrome c family; contains 2 X PS00190 Cytochrome c family heme-binding site signature.	X2BKD0,P63888,P63888	No	intermediary metabolism and respiration			P63888					X2BKD0,P63888					Rv2194		Rv2194			
NC_002945.3	Mycobrowser_v4	CDS	2442807	2443898	.	-	0	Mb2223c	ctaC		PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC	Mb2223c, ctaC, len: 363 aa. Equivalent to Rv2200c,len: 363 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 363 aa overlap). Probable ctaC,transmembrane cytochrome C oxidase (subunit II), COX2,similar e.g. to JT0964 cytochrome-c oxidase chain II (23.0% identity in 317 aa overlap); etc. Contains PS00078 Cytochrome c oxidase subunit II, copper A binding region signature. BELONGS TO THE CYTOCHROME C OXIDASE SUBUNIT 2 FAMILY.	X2BJL3,P63855,P63855	No				P63855					X2BJL3,P63855										
NC_002945.3	Mycobrowser_v4	CDS	2434664	2435776	.	-	0	Mb2215c	trpD		Probable anthranilate phosphoribosyltransferase TrpD	Mb2215c, trpD, len: 370 aa. Equivalent to Rv2192c,len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 370 aa overlap). Probable trpD,anthranilate phosphoribosyltransferase (EC 2.4.2.18) (see citation below), similar to e.g. TRPD_LACCA|P17170, (43.2% identity in 308 aa overlap). Initiation codon uncertain,gtg at 4086 in MTCY190 favoured by homology but this has no clear ribosome binding site.	X2BK14,P66993,P66993	No				P66993					X2BK14,P66993										
NC_002945.3	Mycobrowser_v4	CDS	2438711	2440360	.	+	0	Mb2219	qcrB		Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit)	Mb2219, qcrB, len: 549 aa. Equivalent to Rv2196,len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 549 aa overlap). Probable qcrB,Ubiquinol-cytochrome C reductase cytochrome B subunit (cytB), integral membrane protein, low similarity in amino-terminal half to cytochrome b subunits, highly similar at C-terminus to SW:12KD_MYCLE P15878 12 KD protein PIR:S08427 (86.9% identity in 153 aa overlap). FASTA scores: sp|Q45658|QCRB_BACST MENAQUINOL-CYTOCHROME C REDUCTASE (224 aa) opt: 341, E(): 6.8e-15; 28.0% identity in 207 aa overlap	X2BKE6,P63886,P63886	No	intermediary metabolism and respiration			P63886					X2BKE6,P63886					Rv2196		Rv2196			
NC_002945.3	Mycobrowser_v4	CDS	2441295	2442194	.	-	0	Mb2221c	mmpS3		PROBABLE CONSERVED MEMBRANE PROTEIN MMPS3	Mb2221c, mmpS3, len: 299 aa. Equivalent to Rv2198c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Probable mmpS3,conserved membrane protein (see citation below),equivalent to ML0877|mmpS3 putative membrane protein from Mycobacterium leprae (293 aa), FASTA scores: opt: 1089,E(): 1.2e-43, (69.80% identity in 308 aa overlap). Also similar to other proteins e.g. Rv3209 from Mycobacterium tuberculosis. Contains PS00499 C2 domain signature, a hydrophobic region, and a repetitive proline and threonine rich region. BELONGS TO THE MMPS FAMILY.	X2BK45,P65379,P65379	No				P65379					X2BK45,P65379										
NC_002945.3	Mycobrowser_v4	CDS	2444144	2446102	.	+	0	Mb2224	asnB		Probable asparagine synthetase AsnB	Mb2224, asnB, len: 652 aa. Equivalent to Rv2201,len: 652 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 652 aa overlap). Probable asnB,asparagine synthetase, similar to e.g. SW:ASNH_BACSU P42113 putative asparagine synthetase (26.0% identity in 438 aa overlap)	X2BKF1,P64248,P64248	No	intermediary metabolism and respiration			P64248					X2BKF1,P64248					Rv2201		Rv2201			
NC_002945.3	Mycobrowser_v4	CDS	2446200	2447174	.	-	0	Mb2225c	adok		adenosine kinase	Mb2225c, cbhK, len: 324 aa. Equivalent to Rv2202c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). Probable cbhK,carbohydrate kinase (but not ribose) (EC 2.7.-.-), similar to several e.g. AE000915_1 Methanobacterium thermoautotrop (309 aa) FASTA score: opt: 370, E(): 3.3e-18; 31.2% identity in 276 aa overlap. Low similarity to carbohydrate kinases, e.g. SW:RBSK_BACSU P36945 ribokinase (23.9% identity in 272 aa overlap); contains PS00583 pfkB family of carbohydrate kinases signature 1	X2BK30,P83736,P83736	No				P83736					X2BK30,P83736										
NC_002945.3	Mycobrowser_v4	CDS	2450558	2451643	.	+	0	Mb2230	cobT		Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT	Mb2230, cobT, len: 361 aa. Equivalent to Rv2207,len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 361 aa overlap). Probable cobT,phosphoribosyltransferase, similar to many e.g. SW:COBT_ECOLI P36562 nicotinate-nucleotide--dimethylbenzimidazol phosphoribosyltransferase (34.6% identity in 341 aa overlap)	X2BK38,P63842,P63842	No	intermediary metabolism and respiration			P63842					X2BK38,P63842					Rv2207		Rv2207			
NC_002945.3	Mycobrowser_v4	CDS	2451640	2452389	.	+	0	Mb2231	cobS		Probable cobalamin 5'-phosphate synthase CobS	Mb2231, cobS, len: 249 aa. Equivalent to Rv2208,len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 249 aa overlap). Probable cobS,cobalamin 5'-phosphate synthase; similarity to SW:COBS_ECOLI P36561 cobalamin (5'-phosphate) synthase (28.0% identity in 243 aa overlap)	X2BK50,Q7VEN6,Q7VEN6	No	intermediary metabolism and respiration			Q7VEN6					X2BK50,Q7VEN6					Rv2208		Rv2208			
NC_002945.3	Mycobrowser_v4	CDS	2454011	2455117	.	-	0	Mb2233c	ilvE		branched-chain amino acid transaminase ilve	Mb2233c, ilvE, len: 368 aa. Equivalent to Rv2210c,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 368 aa overlap). Probable ilvE,Branched-chain-amino-acid transaminase, highly similar to many e.g. YWAA_BACSU|P39576 from Bacillus subtilis (48.4% identity in 339 aa overlap); etc.	Q7TYX3,A0A1R3Y0I1	No				A0A1R3Y0I1				IPR001544,IPR005786,IPR018300	Q7TYX3										
NC_002945.3	Mycobrowser_v4	CDS	2455189	2456328	.	-	0	Mb2234c	gcvT		Probable aminomethyltransferase GcvT (Glycine cleavage system T protein)	Mb2234c, gcvT, len: 379 aa. Equivalent to Rv2211c,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Probable gcvT,aminomethyltransferase (EC 2.1.2.10), similar to many e.g. GCST_ECOLI|P27248 for Escherichia coli (38.2% identity in 364 aa overlap); etc. BELONGS TO THE GCVT FAMILY.	X2BKG2,P64221,P64221	No				P64221					X2BKG2,P64221										
NC_002945.3	Mycobrowser_v4	CDS	2457485	2459032	.	+	0	Mb2236	pepB		Probable aminopeptidase PepB	Mb2236, pepB, len: 515 aa. Equivalent to Rv2213,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 515 aa overlap). Probable pepB, leucine aminopeptidase, similar to many e.g. SW:AMPA_ECOLI P11648 aminopeptidase A/I, (41.4% identity in 309 aa overlap). Equivalent to Z98741|MLCB22_6 Mycobacterium leprae cosmid B22; Am (524 aa), FASTA scores: opt: 2793, E(): 0; 83.1% identity in 522 aa overlap. Contains PS00631 Cytosol aminopeptidase signature, NTDAEGRL	X2BK52,Q7VEN5,Q7VEN5	No	intermediary metabolism and respiration			Q7VEN5					X2BK52,Q7VEN5					Rv2213		Rv2213			
NC_002945.3	Mycobrowser_v4	CDS	2459070	2460848	.	-	0	Mb2237c	ephD		Possible short-chain dehydrogenase EphD	Mb2237c, ephD, len: 592 aa. Equivalent to Rv2214c,len: 592 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 592 aa overlap). Possible ephD,short-chain dehydrogenase (EC 1.-.-.-) (see citation below), equivalent to Z98741|MLCB22_8 Mycobacterium leprae cosmid B22; (596 aa), FASTA score: opt: 3262, E(): 0; 80.4% identity in 596 aa overlap. C-terminus similar to short-chain alcohol dehydrogenase family, similar to SW:LIGD_PSEPA Q01198 c alpha-dehydrogenase (30.7% identity in 241 aa overlap); contains PS00061 Short-chain alcohol dehydrogenase family signature, PS00697 ATP-dependent DNA ligase AMP-binding site. N-terminus corresponds to several epoxide hydrolases of plants and Mycobacterium tuberculosis e.g. MTCY9F925	X2BKF0,P66778,P66778	No				P66778					X2BKF0,P66778										
NC_002945.3	Mycobrowser_v4	CDS	2461112	2462773	.	+	0	Mb2238	dlat		dlat, dihydrolipoamide acyltransferase, e2 component of pyruvate dehydrogenase	Mb2238, sucB, len: 553 aa. Equivalent to Rv2215,len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 553 aa overlap). Probable sucB,dihydrolipoamide acetyltransferase component (E2), similar to e.g. SW:O PD2_ACHLA P35489 dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex (35.3% identity in 552 aa overlap); contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.	X2BJM2,P65634,P65634	No	intermediary metabolism and respiration			P65634					X2BJM2,P65634					Rv2215		Rv2215			
NC_002945.3	Mycobrowser_v4	CDS	2463731	2464423	.	+	0	Mb2240	lipB		Probable lipoate biosynthesis protein B LipB	Mb2240, lipB, len: 230 aa. Equivalent to Rv2217,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 230 aa overlap). Probable lipB, similar to SW:LIPB_ECOLI P30976 liopate biosynthesis protein B ( 33.8% identity in 160 aa overlap). Equivalent to gp|Z98741| MLCB22_11 Mycobacterium leprae (235 aa). FASTA score: opt: 1124, E(): 0; 78.4% identity in 218 aa overlap	X2BK54,Q7VEN4,Q7VEN4	No	intermediary metabolism and respiration			Q7VEN4					X2BK54,Q7VEN4					Rv2217		Rv2217			
NC_002945.3	Mycobrowser_v4	CDS	2464420	2465355	.	+	0	Mb2241	lipA		Probable lipoate biosynthesis protein A LipA	Mb2241, lipA, len: 311 aa. Equivalent to Rv2218,len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 311 aa overlap). Probable lipA, lipoic acid synthetase, similar to e.g. SW:LIPA_HAEIN P44463 (42 .6% identity in 291 aa overlap). Equivalent to Z98741|MLCB2 2_12 Mycobacterium leprae cosmid B22; (314 aa). FASTA score : opt: 1836, E(): 0; 86.8% identity in 310 aa overlap	X2BK56,P65284,P65284	No	intermediary metabolism and respiration			P65284					X2BK56,P65284					Rv2218		Rv2218			
NC_002945.3	Mycobrowser_v4	CDS	2466762	2468198	.	+	0	Mb2244	glnA1		GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (GS-I)	Mb2244, glnA1, len: 478 aa. Equivalent to Rv2220,len: 478 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 478 aa overlap). glnA1, glutamine synthetase class I (EC 6.3.1.2) (see first citation below), similar to many e.g. GLNA_STRCO|P15106 from Streptomyces coelicolor, FASTA score: (71.4% identity in 475 aa overlap); etc. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2222c|glnA2, Rv2860c|glnA4, and Rv1878|glnA3. Contains PS00180 Glutamine synthetase signature 1, PS00181 Glutamine synthetase putative ATP-binding region signature, and PS00182 Glutamine synthetase class-I adenylation site. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY.	X2BKH2,P0A591,P0A591	No				P0A591					X2BKH2,P0A591										
NC_002945.3	Mycobrowser_v4	CDS	2468516	2471500	.	-	0	Mb2245c	glnE		GLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE (Glutamine-synthetase adenylyltransferase)	Mb2245c, glnE, len: 994 aa. Equivalent to Rv2221c,len: 994 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 994 aa overlap). glnE,glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) (see citations below), similar to others e.g. GLNE_ECOLI|P30870 glutamate-ammonia-ligase adenylyltransferase from Escherichia coli, FASTA score: (24.4% identity in 721 aa overlap); GLNE_HAEIN|P44419 Glutamate-ammonia-ligase adenylyltransferase from Haemophilus influenzae (981 aa), FASTA score: (28.1% identity in 199 aa overlap); etc. Note that initiation codon uncertain.	X2BK61,P69941,P69941	No				P69941					X2BK61,P69941										
NC_002945.3	Mycobrowser_v4	CDS	2471549	2472889	.	-	0	Mb2246c	glnA2		PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II)	Mb2246c, glnA2, len: 446 aa. Equivalent to Rv2222c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 446 aa overlap). Probable glnA2,glutamine synthetase class II (EC 6.3.1.2), similar to others. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2220|glnA1,Rv2860c|glnA4, and Rv1878|glnA3. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY.	X2BK57,P64246,P64246	No				P64246					X2BK57,P64246										
NC_002945.3	Mycobrowser_v4	CDS	2897527	2897814	.	+	0	Mb2633	vapb41		possible antitoxin vapb41	Mb2633, -, len: 95 aa. Equivalent to Rv2601A, len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.000% identity in 95 aa overlap).	Q7TY94,A0A1R3Y1N9	No	virulence, detoxification, adaptation			A0A1R3Y1N9				IPR010985,IPR013321	Q7TY94					Rv2601A		Rv2601A			
NC_002945.3	Mycobrowser_v4	CDS	2487582	2488523	.	-	0	Mb2260c	cobD		probable cobalamin biosynthesis transmembrane protein cobd	Mb2260c, cobD, len: 313 aa. Equivalent to Rv2236c,len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 313 aa overlap). Probable cobD,conserved membrane protein, similar to PIR:S52223 Rhodobacter capsulatus 945 protein BluD (39.0% identity in 287 aa overlap) involved in cobinamide synthesis, and to SW:COBD_PSEDE Pseudomonas dentrificans cobD protein (37.5% identity in 269 aa overlap), also SW:CBIB_SALTY Salmonella typhimurum cbiB protein (35.5% identity in 304 aa overlap)	X2BKH6,Q7VEN1,Q7VEN1	No				Q7VEN1					X2BKH6,Q7VEN1										
NC_002945.3	Mycobrowser_v4	CDS	2474608	2476170	.	-	0	Mb2248c	caea		probable carboxylesterase caea	Mb2248c, -, len: 520 aa. Equivalent to Rv2224c,len: 520 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 520 aa overlap). Probable exported protease (EC 3.4.-.-); has signal sequence and lipoprotein motif at N-terminal end. Very similar to three proteases/peptidases from Streptomyces spp.: L42758,L42759, L27466. FASTA score: L4 2758|STMSLPD STMSLPD NID: g940302 -Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% identity in 533 aa overlap). Similar to hypothetical protein SW:YZZE_ECOLI P34211 (27.7% identity in 412 aa overlap) and highly similar to Rv2224c and Rv2672 (49.3% identity in 507 aa overlap); contains PS00013, Prokaryotic membrane lipoprotein lipid attachment site, and PS00120 Lipases, serine active site.	X2BJM9,P65824,P65824	No	cell wall and cell processes			P65824					X2BJM9,P65824					Rv2224c		Rv2224c			
NC_002945.3	Mycobrowser_v4	CDS	2476889	2477734	.	+	0	Mb2249	panB		3-methyl-2-oxobutanoate hydroxymethyltransferase panb	Mb2249, panB, len: 281 aa. Equivalent to Rv2225,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Probable panB,3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11), similar to PANB_ECOLI|P31057 3-methyl-2-oxobutanoate hydroxymethyltransferase from Escherichia coli (45.9% identity in 257 aa overlap).	X2BKH7,P0C2T4,P0C2T4	No	intermediary metabolism and respiration			P0C2T4					X2BKH7,P0C2T4					Rv2225		Rv2225			
NC_002945.3	Mycobrowser_v4	misc_RNA	2479592	2479898	.	-	0	rnpB	rnpB		ribonuclease P RNA	rnpB, len: 307 nt. Equivalent to rnpB, len: 307 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 307 nt overlap). rna component of RNase P.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2483753	2484847	.	-	0	Mb2256c	cobC		Possible aminotransferase CobC	Mb2256c, cobC, len: 364 aa. Equivalent to Rv2231c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Possible cobC,aminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC PROTEIN (333 aa) opt: 277, E(): 1.7e-11; 28.8% identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase (27.0% identity in 289 aa overlap), contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site. Real Mycobacterium tuberculosis histidinol-phosphate aminotransferase, hisC, is Rv1600 (MTCY336.04c).	X2BK63,P63501,P63501	No				P63501					X2BK63,P63501										
NC_002945.3	Mycobrowser_v4	CDS	2485426	2486301	.	+	0	Mb2257	ptka		protein tyrosine kinase transcriptional regulatory protein ptka	Mb2257, -, len: 291 aa. Equivalent to Rv2232, len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Conserved hypothetical protein, similar to members of haloacid dehalogenase-like family from several bacteria and to putative phosphatases e.g. Q9I767 and AAK78398. Contains N-terminal extension. FASTA scores: Q9I767 HYPOTHETICAL PROTEIN PA0065 (221 aa) opt: 439 E(): 3.2e-18; 38.679% identity (40.196% ungapped) in 212 aa overlap; >>tr|AAK78398 Predicted phosphatase, HAD family (216 aa) opt: 427, E(): 1.5e-17; 34.762% identity (35.437% ungapped) in 210 aa overlap. Replaces previous Rv2232 and Rv2233.	X2BKI8,P68910	No	regulatory proteins			P68910					X2BKI8					Rv2232		Rv2232			
NC_002945.3	Mycobrowser_v4	CDS	2486294	2486785	.	+	0	Mb2258	ptpA		PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPA (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) (LMW PHOSPHATASE)	Mb2258, ptpA, len: 163 aa. Equivalent to Rv2234,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). ptpA (alternate gene name: MPtpA), low molecular weight protein-tyrosine-phosphatase (see citations below) (EC 3.1.3.48), similar to other phosphotyrosine protein phosphatases e.g. P53433|PTPA_STRCO LOW MOLECULAR WEIGHT PROTEIN-TYROSINE PHOSPHATASE from Streptomyces coelicolor (164 aa), FASTA scores: opt: 455, E(): 3.3e -25, (49.7% identity in 155 aa overlap); PA1S_HUMAN|P24667 red cell acid phosphatase 1, FASTA score: (37.7% identity in 138 aa overlap); etc. Contains a phosphatase catalytic site domain located in N-terminal part. Activity proven biochemically. Supposed a secreted protein.	X2BK81,P65717,P65717	No	regulatory proteins			P65717					X2BK81,P65717					Rv2234		Rv2234			
NC_002945.3	Mycobrowser_v4	CDS	2533741	2535036	.	+	0	Mb2305	lipM		Probable esterase LipM	Mb2305, lipM, len: 431 aa. Equivalent to Rv2284,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). Probable lipM,esterase (EC 3.1.-.-), similar to others e.g. gp|Z95844|MTCY493_28 from Mycobacterium tuberculosis cosmid (420 aa), FASTA scores: opt: 1266, E(): 0, (50.1% identity in 411 aa overlap). Some similarity to G537514 arylacetamide deacetylase (399 aa), FASTA scores: opt: 190, E(): 5.9e-05, (30.4% identity in 138 aa overlap).	Q7VEM0,A0A1R3Y144	No	intermediary metabolism and respiration			A0A1R3Y144				IPR013094	Q7VEM0					Rv2284		Rv2284			
NC_002945.3	Mycobrowser_v4	CDS	2491687	2494392	.	+	0	Mb2265	aceE		pyruvate dehydrogenase e1 component acee (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase)	Mb2265, aceE, len: 901 aa. Equivalent to Rv2241,len: 901 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 901 aa overlap). Probable aceE,pyruvate dehydrogenase E1 component (EC 1.2.4.1), similar to others e.g. ODP1_ECOLI|P06958 pyruvate dehydrogenase E1 component from Escherichia coli, FASTA score: (51.2% identity in 891 aa overlap); etc.	Q7TYW7,A0A1R3Y0S8	No	intermediary metabolism and respiration			A0A1R3Y0S8				IPR004660,IPR005474,IPR009014	Q7TYW7					Rv2241		Rv2241			
NC_002945.3	Mycobrowser_v4	CDS	2495935	2496843	.	+	0	Mb2267	fabD		MALONYL CoA-ACYL CARRIER PROTEIN TRANSACYLASE FABD (Malonyl CoA:AcpM acyltransferase) (MCT)	Mb2267, fabD, len: 302 aa. Equivalent to Rv2243,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). fabD (alternate gene name: mtFabD), malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (see citations below), highly similar to e.g. A57356 acyl-CoA carrier protein malonyltransferase from Streptomyces coelicolor (316 aa),FASTA score: opt: 955, E(): 0, (52.6% identity in 304 aa overlap); FABD_HAEIN|P43712 malonyl CoA-acyl carrier protein transacylase from Haemophilus influenzae, FASTA score: (30.5% identity in 308 aa overlap); and FABD_ECOLI|P25715 from Escherichia coli, FASTA score: (31.4% identity in 309 aa overlap).	X2BK93,P63459,P63459	No	lipid metabolism			P63459					X2BK93,P63459					Rv2243		Rv2243			
NC_002945.3	Mycobrowser_v4	CDS	2496919	2497266	.	+	0	Mb2268	acpM		MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM	Mb2268, acpM, len: 115 aa. Equivalent to Rv2244,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). acpM, acyl carrier protein, meromycolate precursor transport, involved in meromycolate extension (see citations below). Highly similar to others e.g. L43074|STMFABD2|STMFABD|g870805 acyl carrier protein from Streptomyces glaucescens (82 aa), FASTA scores: opt: 298, E(): 8.4e-13, (56.6% identity in 76 aa overlap); and ACP_ECOLI|P02901 acyl carrier protein from Escherichia coli, FASTA score: (37.3% identity in 67 aa overlap); etc.	X2BK70,P0A4W7,P0A4W7	No	lipid metabolism			P0A4W7					X2BK70,P0A4W7					Rv2244		Rv2244			
NC_002945.3	Mycobrowser_v4	CDS	2497263	2498513	.	+	0	Mb2269	kasA		3-OXOACYL-[ACYL-CARRIER PROTEIN] SYNTHASE 1 KASA (BETA-KETOACYL-ACP SYNTHASE) (KAS I)	Mb2269, kasA, len: 416 aa. Equivalent to Rv2245,len: 416 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 416 aa overlap). kasA,beta-ketoacyl-ACP synthase (EC 2.3.1.41), involved in meromycolate extension (see citations below): belongs to the FAS-II system, which utilizes primarily palmitoyl-ACP rather than short-chain acyl-ACP primers. Highly similar to others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP synthase from Streptomyces glaucescens (423 aa), FASTA scores: opt: 1105, E(): 0, (44.6% identity in 417 aa overlap); FABF_ECOLI|P39435 3-oxoacyl-[acyl-carrier-protein] synthase II from Escherichia coli, FASTA score: (39.4% identity in 254 aa overlap); FABB_HORVU|P23902 3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score: (33.4% identity in 413 aa overlap); etc. Strongest similarity to downstream ORF kasB|Rv2246|MTCY427.27 3-oxoacyl-[acyl-carrier-protein] synthase 2 from Mycobacterium tuberculosis (438 aa), FASTA score: (66.3% identity in 409 aa overlap). BELONGS TO THE BETA-KETOACYL-ACP SYNTHASES FAMILY.	X2BKI6,P63455,P63455	No	lipid metabolism			P63455					X2BKI6,P63455					Rv2245		Rv2245			
NC_002945.3	Mycobrowser_v4	CDS	2498544	2499860	.	+	0	Mb2270	kasB		3-OXOACYL-[ACYL-CARRIER PROTEIN] SYNTHASE 2 KASB (BETA-KETOACYL-ACP SYNTHASE) (KAS I)	Mb2270, kasB, len: 438 aa. Equivalent to Rv2246,len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). kasB,beta-ketoacyl-ACP synthase (EC 2.3.1.41), involved in meromycolate extension (see citations below). Highly similar or similar to others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP synthase from Streptomyces glaucescens (423 aa), FASTA scores: opt: 1091, E(): 0, (44.7% identity in 416 aa overlap); FABF_ECOLI|P39435 3-oxoacyl-[acyl-carrier-protein] synthase II from Escherichia coli, FASTA score: (37.0% identity in 411 aa overlap); FABB_HORVU|P23902 3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score: (32.5% identity in 415 aa overlap); etc. Strongest similarity to upstream ORF Rv2245|kasA|MTCY427.26 3-oxoacyl-[acyl-carrier-protein] synthase 1 from Mycobacterium tuberculosis (416 aa), FASTA score: (66.3% identity in 409 aa overlap). BELONGS TO THE BETA-KETOACYL-ACP SYNTHASES FAMILY.	X2BJP8,P63457,P63457	No	lipid metabolism			P63457					X2BJP8,P63457					Rv2246		Rv2246			
NC_002945.3	Mycobrowser_v4	CDS	2499891	2501312	.	+	0	Mb2271	accD6		ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6	Mb2271, accD6, len: 473 aa. Equivalent to Rv2247,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 473 aa overlap). accD6,Acetyl/Propionyl CoA Carboxylase, beta subunit (EC 6.4.1.3) (see citations below), highly similar to e.g. PCCB_RHOSO|Q06101 propionyl-CoA carboxylase beta chain,FASTA score: (75.1% identity in 437 aa overlap). Similar to many other Acetyl/Propionyl CoA Carboxylases from Mycobacterium tuberculosis. BELONGS TO THE ACCD / PCCB FAMILY.	X2BKK0,P63408,P63408	No				P63408					X2BKK0,P63408										
NC_002945.3	Mycobrowser_v4	CDS	2502304	2503854	.	-	0	Mb2273c	glpD1		PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLPD1	Mb2273c, glpD1, len: 516 aa. Equivalent to Rv2249c,len: 516 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 516 aa overlap). Probable glpD1,glycerol-3-phosphate dehydrogenase, similar to SW:GLPD_ECOLI P13035 aerobic glycerol-3-phosphate dehydrogenase (30.0% identity in 486 aa overlap) and SW:GLPA_ECOLI P13032 anaerobic glycerol-3-phosphate dehydrogenase (28.2% identity in 504 aa overlap). Also similar to Rv3302c|glpD2 glycerol-3-phosphate dehydrogenase. COFACTOR: FAD (BY SIMILARITY). BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY.	X2BK71,P64183,P64183	No				P64183					X2BK71,P64183										
NC_002945.3	Mycobrowser_v4	CDS	2526703	2527893	.	+	0	Mb2299	cyp121		Cytochrome P450 121 CYP121	Mb2299, cyp121, len: 396 aa. Equivalent to Rv2276,len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 396 aa overlap). cyp121, cytochrome P450 (EC 1.14.-.-) (see citation below), similar to e.g. G303644 (397 aa) opt: 675, z-score: 776.4, E(): 2.7e-36,(33.7% identity in 407 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY339.42, 29.2% identity in 298 aa overlap.	X2BJT7,P0A515,P0A515	No				P0A515					X2BJT7,P0A515										
NC_002945.3	Mycobrowser_v4	CDS	2511201	2512286	.	+	0	Mb2283	mscr		s-nitrosomycothiol reductase mscr	Mb2283, adhE2, len: 361 aa. Equivalent to Rv2259,len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 361 aa overlap). Probable adhE2,zinc-containing alcohol dehydrogenase, similar to several,especially mycothiol-dependent formaldehyde dehydrogenase from Amycolatopsis methanolica P80094 (360 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. FASTA scores: >sp|P80094|FADH_AMYME NAD/MYCOTHIOL-DEPENDENT FORMALDEHYDE DEHYDROGENASE (MD-FALDH) Length = 360, Expect = e-156, Identities = 268/358 (74%). Also similar to Rv0162c, (MTCI28.02c, 35.0% identity in 371 aa overlap).	Q7VEM6,A0A1R3Y2U2	No				A0A1R3Y2U2				IPR002085,IPR002328,IPR011032,IPR013149,IPR013154,IPR016040,IPR017816	Q7VEM6										
NC_002945.3	Mycobrowser_v4	CDS	2521761	2523230	.	-	0	Mb2291c	cyp128		PROBABLE CYTOCHROME P450 128 CYP128	Mb2291c, cyp128, len: 489 aa. Equivalent to Rv2268c, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 489 aa overlap). Probable cyp128, cytochrome P450 (EC 1.14.-.-), similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620,E(): 8.3e-33, (31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature, similar to MTCY50.26, 32.7% identity in 382 aa overlap	X2BKL8,P63714,P63714	No	intermediary metabolism and respiration			P63714					X2BKL8,P63714					Rv2268c		Rv2268c			
NC_002945.3	Mycobrowser_v4	CDS	2519058	2520344	.	+	0	Mb2289	cyp124		Probable cytochrome P450 124 CYP124	Mb2289, cyp124, len: 428 aa. Equivalent to Rv2266,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). Probable cyp124,cytochrome P450 (EC 1.14.-.-), similar to e.g. G405543 cytochrome P450 (406 aa), FASTA scores, opt: 763,E(): 0,(35.4% identity in 393 aa overlap), similar to e.g. MTCY50.26, 33.8% identity in 370 aa overlap	X2BKK6,P0A517,P0A517	No				P0A517					X2BKK6,P0A517										
NC_002945.3	Mycobrowser_v4	CDS	2530769	2532427	.	+	0	Mb2302	pitB		Putative phosphate-transport permease PitB	Mb2302, pitB, len: 552 aa. Equivalent to Rv2281,len: 552 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 552 aa overlap). Putative pitB,phosphate-transport permease, integral membrane protein,similar to YG04_HAEIN P45268 putative phosphate permease hi1604 (420 aa). FASTA scores, opt: 484, E(): 5e-23,(33.5% identity in 498 aa overlap) also to G399598 amphotropic murine retrovirus receptor (656 aa) FASTA scores, opt: 453, E(): 5.8e-21, (26.8% identity in 645 aa overlap). Also similar to Rv0545c|pitA from M. tuberculosis. BELONGS TO THE PIT SUBFAMILY.	X2BK88,P65713,P65713	No	cell wall and cell processes			P65713					X2BK88,P65713					Rv2281		Rv2281			
NC_002945.3	Mycobrowser_v4	CDS	2537299	2538927	.	+	0	Mb2309	yjcE		Probable conserved integral membrane transport protein YjcE	Mb2309, yjcE, len: 542 aa. Equivalent to Rv2287,len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 542 aa overlap). Probable yjcE,conserved integral membrane transport protein, similar to eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065 Putative Na(+)/H(+) exchanger from Escherichia coli (549 aa), FASTA scores: opt: 436, E(): 5.6e-21, (29.4% identity in 555 aa overlap); etc. SEEMS TO BELONG TO CPA1 FAMILY (NA(+)/H(+) EXCHANGER FAMILY).	X2BJV4,P65527,P65527	No	cell wall and cell processes			P65527					X2BJV4,P65527					Rv2287		Rv2287			
NC_002945.3	Mycobrowser_v4	CDS	2539271	2540053	.	+	0	Mb2311	cdh		Probable CDP-diacylglycerol pyrophosphatase Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase)	Mb2311, cdh, len: 260 aa. Equivalent to Rv2289,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Probable cdh,CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26), similar to CDH_SALTY|P26219 cdp-diacylglycerol pyrophosphatase (251 aa), FASTA scores: opt: 395, E(): 5.9e-20, (33.5% identity in 221 aa overlap).	X2BKE3,P63752,P63752	No	lipid metabolism			P63752					X2BKE3,P63752					Rv2289		Rv2289			
NC_002945.3	Mycobrowser_v4	CDS	2540195	2540350	.	+	0	Mb2312	lppOa		Probable conserved lipoprotein lppOa	Mb2312, lppOa, len: 51 aa. Equivalent to 5' end of Rv2290, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 39 aa overlap). Probable lppO, conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kd lipoprotein antigen precursor (159 aa) FASTA scores, opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). ???Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, lppO exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb.	Q7VEL7,A0A1R3Y2X6	No				A0A1R3Y2X6					Q7VEL7										
NC_002945.3	Mycobrowser_v4	CDS	2540344	2540709	.	+	0	Mb2313	lppOb		Probable conserved lipoprotein lppOb	Mb2313, lppOb, len: 121 aa. Equivalent to 3' end of Rv2290, len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 121 aa overlap). Probable lppO, conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kd lipoprotein antigen precursor (159 aa) FASTA scores, opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, lppO exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb.	Q7VEL6,A0A1R3Y1J8	No				A0A1R3Y1J8					Q7VEL6										
NC_002945.3	Mycobrowser_v4	CDS	2540851	2541621	.	+	0	Mb2314	sseB		Probable thiosulfate sulfurtransferase SseB	Mb2314, sseB, len: 256 aa. Equivalent to 3' end of Rv2291, len: 284 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 256 aa overlap). Probable sseB, thiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0; Smith-Waterman score: 765; 46.9% identity in 286 aa overlap, similar to THTR_ECOLI P31142 putative thiosulfate sulfurtransferase (280 aa), FASTA scores, opt: 478, E(): 1e-23, (35.1% identity in 265 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 5' start due to a 2 bp deletion (tg-*),leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (256 aa versus 284 aa).	Q7VEL5,A0A1R3Y0Y9	No				A0A1R3Y0Y9				IPR001307,IPR001763	Q7VEL5										
NC_002945.3	Mycobrowser_v4	CDS	2594783	2595178	.	+	0	Mb2368	mmpL9b		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL9B [SECOND PART]	Mb2368, mmpL9b, len: 131 aa. Equivalent to 3' end of Rv2339, len: 962 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 131 aa overlap). Probable mmpL9, conserved transmembrane transport protein (see citation below), with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity in 937 aa overlap); G699237|U1740AB from Mycobacterium leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from M. tuberculosis. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, truncation due to a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b.	Q7TYS5,A0A1R3Y0Y1	No				A0A1R3Y0Y1				IPR004869	Q7TYS5										
NC_002945.3	Mycobrowser_v4	CDS	2547654	2549597	.	-	0	Mb2321c	htpG		PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	Mb2321c, htpG, len: 647 aa. Equivalent to Rv2299c,len: 647 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 647 aa overlap). htpG, probable chaperone, HSP90 familyHEAT SHOCK PROTEIN HSP90 FAMILY. Similar to HTPG_BACSU|P46208 heat shock protein htpG homologue from Bacillus subtilis (626 aa), FASTA scores: opt: 1551, E(): 0, (39.6% identity in 631 aa overlap). Contains possible helix-turn-helix motif at aa 519-540 (+3.77 SD). BELONGS TO THE HEAT SHOCK PROTEIN 90 FAMILY.	X2BKF3,P64412,P64412	No				P64412					X2BKF3,P64412										
NC_002945.3	Mycobrowser_v4	CDS	2550610	2551302	.	+	0	Mb2323	cut2		PROBABLE CUTINASE CUT2	Mb2323, cut2, len: 230 aa. Equivalent to Rv2301,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Probable cut2 (alternate gene name: cfp25), cutinase (EC 3.1.1.-),highly similar to others from Mycobacteria tuberculosis e.g. MTCY13E12.04|Rv3451|O06318|CUT3_MYCTU (247 aa), FASTA scores: opt: 569, E(): 2.3e-27, (45.3% identity in 223 aa overlap); MT2037|MTCY39.35|RV1984C|Q10837|CUT1_MYCTU (217 aa), FASTA scores: opt: 383, E(): 3.4e-16 (42.9% identity in 217 aa overlap); O69691|Rv3724|MTV025.072 PUTATIVE CUTINASE PRECURSOR (187 aa), FASTA scores: opt: 248, E(): 4.3e-08, (41.85% identity in 172 aa overlap); etc. Also similar to few others from other organisms e.g. Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 391, E(): 1.1e-16, (39.15% identity in 235 aa overlap); etc. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. BELONGS TO THE CUTINASE FAMILY. Start changed since first submission (+11 aa).	X2BKP1,P63882,P63882	No	cell wall and cell processes			P63882					X2BKP1,P63882					Rv2301		Rv2301			
NC_002945.3	Mycobrowser_v4	CDS	2835607	2836020	.	+	0	Mb2576	vapc18		possible toxin vapc18	Mb2576, -, len: 137 aa. Equivalent to Rv2546, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). Conserved hypothetical protein. Some similarity to several HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. P96411|Rv0229c|MTCY08D5.24c (226 aa), FASTA scores: opt: 272, E(): 1.3e-11, (39.7% identity in 136 aa overlap); O33299|Rv2757c|MTV002.22c (138 aa), FASTA scores: opt: 265, E(): 2.5e-11, (38.5% identity in 135 aa overlap); P95026|Rv2527|MTCY159.29c (133 aa), FASTA scores: opt: 206, E(): 2.6e-07, (38.0% identity in 100 aa overlap); etc.	Q7TYB9	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TYB9	A0A1R3Y1I5				Rv2546		Rv2546			
NC_002945.3	Mycobrowser_v4	CDS	2581290	2581817	.	-	0	Mb2357c	lppP		PROBABLE LIPOPROTEIN LPPP	Mb2357c, lppP, len: 175 aa. Equivalent to Rv2330c,len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 175 aa overlap). Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	X2BKC1,P65303,P65303	No				P65303					X2BKC1,P65303										
NC_002945.3	Mycobrowser_v4	CDS	2566433	2567305	.	+	0	Mb2343	uspA		PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPA	Mb2343, uspA, len: 290 aa. Equivalent to Rv2316,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 290 aa overlap). Probable uspA,sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN8|USPA|ML1768 SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (328 aa), FASTA scores: opt: 1593,E(): 1.9e-93, (82.35% identity in 289 aa overlap); and similar to O32940|ML1426|MLCB2052.28 POSSIBLE SUGAR TRANSPORT PROTEIN (PROBABLE ABC-TRANSPORT PROTEIN, INNER MEMBRANE COMPONENT) from Mycobacterium leprae (319 aa),FASTA scores: opt: 600, E(): 9.2e-31, (34.25% identity in 295 aa overlap). Also similar to other proteins involved in transport e.g. Q9X860|SCE134.05c PUTATIVE BINDING PROTEIN DEPENDENT TRANSPORT PROTEIN from Streptomyces coelicolor (327 aa), FASTA scores: opt: 639, E(): 3.2e-33,(40.45% identity in 272 aa overlap); Q9K6N9|BH3689 SUGAR TRANSPORT SYSTEM (PERMEASE) from Bacillus halodurans (300 aa), FASTA scores: opt: 590, E(): 3.7e-30, (35.65% identity in 289 aa overlap); etc.	Q7TYU3,A0A1R3Y1M8	No	cell wall and cell processes			A0A1R3Y1M8				IPR000515	Q7TYU3					Rv2316		Rv2316			
NC_002945.3	Mycobrowser_v4	CDS	2572294	2572959	.	-	0	Mb2349c	rocD1		PROBABLE ORNITHINE AMINOTRANSFERASE (N-terminus part) ROCD1 (ORNITHINE--OXO-ACID AMINOTRANSFERASE)	Mb2349c, rocD1, len: 221 aa. Equivalent to Rv2322c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable rocD1,ornithine aminotransferase (EC: 2.6.1.13), highly similar to N-terminal region of other ornithine aminotransferases,e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa),FASTA scores: opt: 770, E(): 8.7e-40, (55.7% identity in 201 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa) FASTA scores: opt: 632,E(): 2.2e-31, (46.1% identity in 208 aa overlap); P38021|OAT_BACSU|ROCD from Bacillus subtilis (401 aa),FASTA scores: opt: 626, E(): 5.1e-31, (43.1% identity in 218 aa overlap); etc. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Rv2322c|MTCY3G12.12 and Rv2321c|MTCY3G12.13 (upstream ORF) appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this.	Q7TYT8,A0A1R3Y0W6	No				A0A1R3Y0W6				IPR005814,IPR010164,IPR015421,IPR015422,IPR015424	Q7TYT8										
NC_002945.3	Mycobrowser_v4	CDS	2567292	2568116	.	+	0	Mb2344	uspB		PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPB	Mb2344, uspB, len: 274 aa. Equivalent to Rv2317,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Probable uspB,sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN7|USPE|ML1769 SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (274 aa), FASTA scores: opt: 1522,E(): 3.4e-89, (85.0% identity in 274 aa overlap); and similar to O32941|ML1425|MLCB2052.29 PROBABLE ABC-TRANSPORT PROTEIN, INNER MEMBRANE COMPONENT from Mycobacterium leprae (283 aa), FASTA scores: opt: 630,E(): 8.4e-33, (36.55% identity in 268 aa overlap). Also similar to other integral membrane proteins e.g. P73854|LACG|SLR1723 LACTOSE TRANSPORT SYSTEM PERMEASE PROTEIN from Synechocystis sp. strain PCC 6803 (270 aa),FASTA scores: opt: 605, E(): 3.1e-31, (36.0% identity in 264 aa overlap); Q9F3B8|SC5F1.11 PUTATIVE SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (307 aa), FASTA scores: opt: 582, E(): 9.7e-30, (34.45% identity in 264 aa overlap); etc. Also similar to O53483|Rv2039c|MTV018.26c SUGAR TRANSPORT PROTEIN from Mycobacterium tuberculosis (280 aa), FASTA scores: opt: 630, E(): 8.3e-89, (37.7% identity in 268 aa overlap).	Q7TYU2,A0A1R3Y122	No	cell wall and cell processes			A0A1R3Y122				IPR000515	Q7TYU2					Rv2317		Rv2317			
NC_002945.3	Mycobrowser_v4	CDS	2568113	2569435	.	+	0	Mb2345	uspC		PROBABLE PERIPLASMIC SUGAR-BINDING LIPOPROTEIN USPC	Mb2345, uspC, len: 440 aa. Equivalent to Rv2318,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 440 aa overlap). Probable uspC,sugar-binding lipoprotein component of sugar transport system (see citation below), most similar to Q9CBN6|USPC|ML1770 SUGAR TRANSPORT PERIPLASMIC BINDING PROTEIN from Mycobacterium leprae (446 aa), FASTA scores: opt: 2294, E(): 8.1e-135, (74.7% identity in 446 aa overlap). Also similar to other substrate-binding proteins e.g. Q9RK89|SCF1.15 PUTATIVE SUBSTRATE BINDING PROTEIN (EXTRACELLULAR) (BINDING-PROTEIN-DEPENDENT TRANSPORT) (FRAGMENT) from Streptomyces coelicolor (221 aa), FASTA scores: opt: 377, E(): 3e-16, (32.25% identity in 217 aa overlap); Q9K6N8|BH3690 SUGAR TRANSPORT SYSTEM (SUGAR-BINDING PROTEIN) from Bacillus halodurans (420 aa),FASTA scores: opt: 227, E(): 1e-06, (25.00% identity in 452 aa overlap); etc. Also similar to O53485|Rv2041c|MTV018.28C LIPOPROTEIN COMPONENT OF SUGAR TRANSPORT SYSTEM from Mycobacterium tuberculosis (439 aa),FASTA scores: opt: 246, E(): 7e-08, (26.75% identity in 325 aa overlap). Contains a hydrophobic stretch (possible signal peptide) at N-terminal end.	Q7TYU1,A0A1R3Y187	No	cell wall and cell processes			A0A1R3Y187				IPR006059	Q7TYU1					Rv2318		Rv2318			
NC_002945.3	Mycobrowser_v4	CDS	2570318	2571748	.	-	0	Mb2347c	rocE		PROBABLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN ROCE	Mb2347c, rocE, len: 476 aa. Equivalent to Rv2320c,len: 476 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 476 aa overlap). Probable rocE,cationic amino acid (especially arginine and ornithine) transporter (permease), highly similar to other amino acid transporters e.g. Q9L100|SCL6.16C PUTATIVE AMINO ACID TRANSPORTER from Streptomyces coelicolor (496 aa), FASTA scores: opt: 1485, E(): 9.4e-82, (48.4% identity in 477 aa overlap); O06479|YFNA PUTATIVE AMINO ACID TRANSPORTER from Bacillus subtilis (462 aa), FASTA scores: opt: 1271, E(): 6.1e-69, (41.9% identity in 463 aa overlap); Q9PG94|XF0408 AMINO ACID TRANSPORTER from Xylella fastidiosa (509 aa),FASTA scores: opt: 1128, E(): 2.5e-60, (39.5% identity in 481 aa overlap); etc. Also some similarity with Z99108.1|BSUB0005 from Bacillus subtilis (461 aa), FASTA scores: opt: 1271, E(): 0, (41.9% identity in 463 aa overlap); and G403170 ETHANOLAMINE PERMEASE (488 aa),FASTA scores: opt: 468, E(): 1e-23, (28.1% identity in 462 aa overlap). SEEMS TO BELONG TO THE APC FAMILY.	Q7TYU0,A0A1R3Y0V6	No				A0A1R3Y0V6				IPR002293	Q7TYU0										
NC_002945.3	Mycobrowser_v4	CDS	2571749	2572294	.	-	0	Mb2348c	rocD2		PROBABLE ORNITHINE AMINOTRANSFERASE (C-terminus part) ROCD2 (ORNITHINE--OXO-ACID AMINOTRANSFERASE)	Mb2348c, rocD2, len: 181 aa. Equivalent to Rv2321c,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Probable rocD2,ornithine aminotransferase (EC: 2.6.1.13), highly similar to C-terminal region of other ornithine aminotransferases,e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa),FASTA scores: opt: 628, E(): 1.2e-32, (55.35% identity in 168 aa overlap); P3802|OAT_BACSU|ROCD from Bacillus subtilis (401 aa), FASTA scores: opt: 477, E(): 4.3e-23,(42.1% identity in 178 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa),FASTA scores: opt: 437, E(): 1.5e-20, (41.3% identity in 170 aa overlap); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Rv2322c|MTCY3G12.12 (upstream ORF) and Rv2321c|MTCY3G12.13 appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this.	Q7TYT9,A0A1R3Y0W4	No				A0A1R3Y0W4				IPR005814,IPR010164,IPR015421,IPR015422,IPR015424	Q7TYT9										
NC_002945.3	Mycobrowser_v4	CDS	2578326	2579474	.	+	0	Mb2355	PE23		pe family protein pe23	Mb2355, PE23, len: 382 aa. Equivalent to Rv2328,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 382 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS HOMOLOG from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18,(34.65% identity in 401 aa overlap); etc.	X2BKT3,P0A685,P0A685	No	PE/PPE			P0A685					X2BKT3,P0A685					Rv2328		Rv2328			
NC_002945.3	Mycobrowser_v4	CDS	2579509	2581056	.	-	0	Mb2356c	narK1		PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK1 (NITRITE FACILITATOR 1)	Mb2356c, narK1, len: 515 aa. Equivalent to Rv2329c,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 515 aa overlap). Probable narK1,nitrite extrusion protein, possibly member of major facilitator superfamily (MFS). Equivalent to O32974|MLCB22.41c|NARK|ML0844 PUTATIVE NITRITE EXTRUSION PROTEIN from Mycobacterium leprae (517 aa), FASTA scores: opt: 2224, E(): 1.9e-129, (69.3% identity in 488 aa overlap). Also highly similar to others e.g. P94933 NITRITE EXTRUSION PROTEIN from Mycobacterium fortuitum (471 aa), FASTA scores: opt: 1969, E(): 8.6e-114, (62.1% identity in 459 aa overlap); P37758|NARU_ECOLI NITRITE EXTRUSION PROTEIN 2 from Escherichia coli strain K12 (462 aa), FASTA scores: opt: 792, E(): 2.3e-41, (36.95% identity in 476 aa overlap); P10903|NARK_ECOLI nitrite extrusion protein (nitrite facilitator 1) from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 784, E(): 7e-41, (35.3% identity in 468 aa overlap); etc. Also similar to RV0261c|Z86089|MTCY6A4_5 from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 2000, E(): 1.1e-115, (62.6% identity in 470 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS.	Q7TYT4,A0A1R3Y0T4	No				A0A1R3Y0T4				IPR011701,IPR016196	Q7TYT4										
NC_002945.3	Mycobrowser_v4	CDS	2582703	2584349	.	+	0	Mb2360	mez		PROBABLE [NAD] DEPENDENT MALATE OXIDOREDUCTASE MEZ (MALIC ENZYME) (NAD-MALIC ENZYME) (MALATE DEHYDROGENASE (OXALOACETATE DECARBOXYLATING)) (PYRUVIC-MALIC CARBOXYLASE) (NAD-ME)	Mb2360, mez, len: 548 aa. Equivalent to Rv2332,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 548 aa overlap). Probable mez, malate oxidoreductase [NAD] dependant (EC 1.1.1.38) (malic enzyme), highly similar to others e.g. O34389|MALS PUTATIVE MALOLACTIC ENZYME [INCLUDES: MALIC ENZYME (EC 1.1.1.-); L-LACTATE DEHYDROGENASE (EC 1.1.1.27)] from Bacillus subtilis (566 aa), FASTA scores: opt: 1927, E(): 5.5e-111, (52.9% identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA PROBABLE NAD-DEPENDENT MALIC ENZYME from Bacillus subtilis (582 aa), FASTA scores: opt: 1849,E(): 3.6e-106, (50.45% identity in 543 aa overlap); Q48796|MLES_OENOE MALOLACTIC ENZYME from Oenococcus oeni (541 aa), FASTA scores: opt: 1540, E(): 3.6e-87, (44.2% identity in 536 aa overlap); etc. BELONGS TO THE MALIC ENZYMES FAMILY. N-terminus shortened since first submission (previously 652 aa).	Q7TYT2,A0A1R3Y0Y2	No	intermediary metabolism and respiration			A0A1R3Y0Y2				IPR001891,IPR012301,IPR012302,IPR015884,IPR016040	Q7TYT2					Rv2332		Rv2332			
NC_002945.3	Mycobrowser_v4	CDS	2584346	2585917	.	-	0	Mb2361c	stp		integral membrane drug efflux protein stp	Mb2361c, -, len: 523 aa. Equivalent to Rv2333c,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 508 aa overlap). Probable conserved integral membrane transport protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug, highly similar to many e.g. Q9RL22|C5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 1031,E(): 4e-55, (37.4% identity in 412 aa overlap); Q9L0L9|SCD82.12 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (490 aa), FASTA scores: opt: 883,E(): 3.8e-46, (36.35% identity in 407 aa overlap); Q9ZBW5|SC4B5.03c PUTATIVE INTEGRAL MEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (504 aa), FASTA scores: opt: 899, E(): 4.1e-47, (37.4% identity in 415 aa overlap); P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa), FASTA scores: opt: 839, E(): 1.9e-43, (32.3% identity in 489 aa overlap); etc. Also highly similar to Rv2459|O53186|MTV008.15 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (508 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.05% identity in 504 aa overlap); and AAK46834|MT2534 DRUG TRANSPORTER from Mycobacterium tuberculosis strain CDC1551 (523 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.4% identity in 504 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa).	Q7TYT1,A0A1R3Y0V9	No	cell wall and cell processes			A0A1R3Y0V9				IPR001411,IPR004638,IPR005829,IPR011701,IPR016196,IPR020846	Q7TYT1					Rv2333c		Rv2333c			
NC_002945.3	Mycobrowser_v4	CDS	2605762	2607606	.	-	0	Mb2377c	PPE40		ppe family protein ppe40	Mb2377c, PPE40, len: 614 aa. Equivalent to Rv2356c,len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 615 aa overlap). Member of Mycobacterium tuberculosis PPE_family, highly similar to others e.g. Q10778|MTCY48.17|YF48_MYCTU HYPOTHETICAL PPE-FAMILY PROTEIN (678 aa), FASTA scores: opt: 1888, E(): 1.9e-78, (54.4% identity in 667 aa overlap); Q10540|MTCY31.06c, E241779|MTCY98, P42611|MTV037.06c,Q10813|MTCY274.23c, P71657|MTCY02B10.25c, MTCY03C7.23,P71869|MTCY03C7.24c, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (gcg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (614 aa versus 615 aa).	Q7TYR8,A0A1R3Y0Z4	No				A0A1R3Y0Z4				IPR000030,IPR002989	Q7TYR8										
NC_002945.3	Mycobrowser_v4	CDS	2586392	2587324	.	+	0	Mb2362	cysK1		cysteine synthase a cysk1 (o-acetylserine sulfhydrylase a) (o-acetylserine (thiol)-lyase a) (csase a)	Mb2362, cysK1, len: 310 aa. Equivalent to Rv2334,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Probable cysK1,cysteine synthase A (EC 4.2.99.8), equivalent to O32978|CYSK_MYCLE|ML0839|MLCB22.47 CYSTEINE SYNTHASE A from Mycobacterium leprae (310 aa), FASTA scores: opt: 1756, E(): 8.6e-96, (85.8% identity in 310 aa overlap). Also highly similar to other CYSTEINE SYNTHASES e.g. Q9JQL6|CYSK|NMA0974|NMB0763 PUTATIVE CYSTEINE SYNTHASE from Neisseria meningitidis (serogroup A and B) (310 aa),FASTA scores: opt: 1368, E(): 4.6e-73, (66.45% identity in 310 aa overlap); P73410|CYSK_SYNY3|SLR1842 from Synechocystis sp (312 aa), FASTA scores: opt: 1310, E(): 1.2e-69, (64.65% identity in 311 aa overlap); Q43725|CYSM_ARATH|OASC|ACS1|AT3G59760|F24G16.30 CYSTEINE SYNTHASE (MITOCHONDRIAL PRECURSOR) from Arabidopsis thaliana (Mouse-ear cress) (424 aa), FASTA scores: opt: 1253, E(): 3.2e-66, (59.2% identity in 309 aa overlap) (has its N-terminus longer 104 aa); etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Note that previously known as cysK.	X2BKC8,P0A535,P0A535	No				P0A535					X2BKC8,P0A535										
NC_002945.3	Mycobrowser_v4	CDS	3093580	3093795	.	-	0	Mb2854c	vapb22		possible antitoxin vapb22	Mb2854c, -, len: 71 aa. Equivalent to Rv2830c, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 71 aa overlap). Hypothetical protein,some similarity to Z97182|MTCY19H5.26|Rv0596c Hypothetical protein from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 88, E(): 1.3, (41.7% identity in 36 aa overlap); and to PHD_BPP1|Q06253 bacteriophage P1 phd gene (73 aa), FASTA scores: opt: 79, E(): 3.8, (35.9% identity in 39 aa overlap).	Q7TXR7,A0A1R3Y2D2	No	virulence, detoxification, adaptation			A0A1R3Y2D2				IPR006442	Q7TXR7					Rv2830c		Rv2830c			
NC_002945.3	Mycobrowser_v4	CDS	2587328	2588017	.	+	0	Mb2363	cysE		PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT)	Mb2363, -, len: 229 aa. Equivalent to Rv2335, len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Probable cysE, serine acetyltransferase (EC 2.3.1.30), equivalent to O32979|CYSE|ML0838 SERINE ACETYLTRANSFERASE from Mycobacterium leprae (227 aa), FASTA scores: opt: 1152,E(): 9.6e-62, (76.4% identity in 229 aa overlap). Also highly similar, except in C-terminal part, to others e.g. Q9HXI6|CYSE|PA3816 O-ACETYLSERINE SYNTHASE from Pseudomonas aeruginosa (258 aa), FASTA scores: opt: 737,E(): 6e-37, (61.3% identity in 168 aa overlap); P23145|NIFP_AZOCH PROBABLE SERINE ACETYLTRANSFERASE from Azotobacter chroococcum mcd 1 (269 aa), FASTA scores: opt: 718, E(): 8.4e-36, (55.45% identity in 220 aa overlap); Q06750|CYSE_BACSU SERINE ACETYLTRANSFERASE from Bacillus subtilis (217 aa), FASTA scores: opt: 640, E(): 3.1e-31,(48.0% identity in 200 aa overlap); etc. Contains PS00101 Bacterial hexapeptide-repeat containing-transferases signature. BELONGS TO THE CYSE/LACA/LPXA/NODL FAMILY OF ACETYLTRANSFERASES. COMPOSED OF MULTIPLE REPEATS OF [LIV]-G-X(4).	Q7TYT0,A0A1R3Y1P8	No	intermediary metabolism and respiration			A0A1R3Y1P8				IPR001451,IPR005881,IPR011004,IPR018357	Q7TYT0					Rv2335		Rv2335			
NC_002945.3	Mycobrowser_v4	CDS	2590703	2591659	.	-	0	Mb2366c	moeW		POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEW	Mb2366c, moeW, len: 318 aa. Equivalent to Rv2338c,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Possible moeW,molybdoptenum biosynthesis protein, showing some similarity to several molybdopterin biosynthesis proteins e.g. O27613|MTH1571 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEB HOMOLOG from Methanobacterium thermoautotrophicum (251 aa), FASTA scores: opt: 309, E(): 4.7e-14; (30.7% identity in 254 aa overlap); Q9KPQ5|VC2311 HESA/MOEB/THIF FAMILY PROTEIN from Vibrio cholerae (273 aa), FASTA scores: opt: 255, E(): 4e-09, (36.25% identity in 149 aa overlap); Q9PD34|XF1545 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Xylella fastidiosa (276 aa), FASTA scores: opt: 233,E(): 1e-07, (33.6% identity in 128 aa overlap); etc. SEEMS TO BELONG TO THE HESA/MOEB/THIF FAMILY.	Q7TYS7,A0A1R3Y0U6	No				A0A1R3Y0U6				IPR000594,IPR009036,IPR016040	Q7TYS7										
NC_002945.3	Mycobrowser_v4	CDS	2592290	2594770	.	+	0	Mb2367	mmpL9a		PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL9A [FIRST PART]	Mb2367, mmpL9a, len: 826 aa. Equivalent to 5' end of Rv2339, len: 962 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 826 aa overlap). Probable mmpL9, conserved transmembrane transport protein (see citation below), with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity in 937 aa overlap); G699237|U1740AB from Mycobacterium leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from M. tuberculosis. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, truncation due to a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b, resulting in a shorter mmpL9a product.	Q7TYS6,A0A1R3Y0X6	No				A0A1R3Y0X6				IPR004869	Q7TYS6										
NC_002945.3	Mycobrowser_v4	CDS	2595264	2596505	.	-	0	Mb2369c	PE_PGRS39		pe-pgrs family protein pe_pgrs39	Mb2369c, PE_PGRS39, len: 413 aa. Equivalent to Rv2340c, len: 413 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 413 aa overlap). Member of the Mycobacterium tuberculosis PE_family, PGRS subfamily of gly-rich proteins, similar to others eg YI18_MYCTU|Q50615|Rv1818c|MTCY1A11.25 PE-PGRS FAMILY PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 710, E(): 1.4e-22, (41.0% identity in 368 aa overlap); O53884|Rv0872v|MTV043.65c PGRS-FAMILY PROTEIN from Mycobacterium tuberculosis (606 aa), FASTA scores: opt: 708, E(): 1.9e-22, (42.4% identity in 389 aa overlap); etc.	Q7TYS4,A0A1R3Y0X9	No				A0A1R3Y0X9				IPR000084	Q7TYS4										
NC_002945.3	Mycobrowser_v4	CDS	2597194	2597613	.	+	0	Mb2370	lppQ		PROBABLE CONSERVED LIPOPROTEIN LPPQ	Mb2370, lppQ, len: 139 aa. Equivalent to Rv2341,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable lppQ,conserved lipoprotein, showing some similarity with Rv1228|O33224|LPQX|MTCI61.11 from Mycobacterium tuberculosis (185 aa), FASTA scores: opt: 155; E(): 0.0073; (31.9% identity in 116 aa overlap). Also shows few similarity with P29228|VLPA_MYCHR variant surface antigen A precursor from Mycoplasma hyorhinis (157 aa), FASTA scores: opt: 96, E(): 7.3, (23.1% identity in 143 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TYS3,A0A1R3Y0Y8	No	cell wall and cell processes			A0A1R3Y0Y8					Q7TYS3					Rv2341		Rv2341			
NC_002945.3	Mycobrowser_v4	CDS	2611532	2612329	.	-	0	Mb2383c	reco		possible dna repair protein reco	Mb2383c, -, len: 265 aa. Equivalent to Rv2362c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Conserved hypothetical protein, equivalent to the Mycobacterium leprae proteins Q49754|B1937_F1_25 Hypothetical protein (269 aa), FASTA scores: opt: 1561, E(): 8.5e-93, (86.6% identity in 268 aa overlap); and Q9CCN0|ML0633 Hypothetical protein (268 aa), FASTA scores: opt: 1560,E(): 8.5e-93, (86.6% identity in 268 aa overlap). Also highly similar to Q9L2H3|SCC121.13c HYPOTHETICAL 27.1 KDA PROTEIN from Streptomyces coelicolor (251 aa), FASTA scores: opt: 843, E(): 6.9e-47, (52.2% identity in 249 aa overlap); ans similar to other hypothetical proteins. Weak similarity with P42095|RECO_BACSU DNA REPAIR PROTEIN RECOMBINASE from Bacillus subtilis (255 aa), FASTA scores: opt: 270, E(): 3.6e-10, (26.4% identity in 182 aa overlap).	X2BKV0,P65984,P65984	No	information pathways			P65984					X2BKV0,P65984					Rv2362c		Rv2362c			
NC_002945.3	Mycobrowser_v4	CDS	2598130	2600049	.	-	0	Mb2372c	dnaG		PROBABLE DNA PRIMASE DNAG	Mb2372c, dnaG, len: 639 aa. Equivalent to Rv2343c,len: 639 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 639 aa overlap). Probable dnaG, DNA primase (EC 2.7.7.-), equivalent to O52200|PRIM_MYCSM|DNAG DNA PRIMASE from Mycobacterium smegmatis (636 aa), FASTA scores: opt: 3504, E(): 5.5e-202, (81.55% identity in 639 aa overlap); and Q9CCG2|DNAG|ML0833 DNA PRIMASE from Mycobacterium leprae (642 aa), FASTA scores: opt: 3443,E(): 2.5e-198, (80.4% identity in 642 aa overlap). Also highly similar to many DNA primases e.g. Q9S1N4|PRIM_STRCO|DNAG|SC7A8.07c from Streptomyces coelicolor (641 aa), FASTA scores: opt: 1899, E(): 5.1e-106, (47.9% identity in 643 aa overlap); P74893|PRIM_SYNP7|DNAG from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (616 aa), FASTA scores: opt: 860, E(): 6.6e-44, (35.3% identity in 513 aa overlap); P05096|PRIM_BACSU from Bacillus subtilis (603 aa) FASTA scores: opt: 800, E(): 2.5e-40, (33.7% identity in 430 aa overlap); etc.	X2BKE2,P63963,P63963	No				P63963					X2BKE2,P63963										
NC_002945.3	Mycobrowser_v4	CDS	2600054	2601349	.	-	0	Mb2373c	dgt		PROBABLE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DGT (DGTPASE) (DGTP TRIPHOSPHOHYDROLASE)	Mb2373c, dgt, len: 431 aa. Equivalent to Rv2344c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). Probable dgt,deoxyguanosine triphosphate triphosphohydrolase (EC 3.1.5.1), equivalent to Q9CCG3|DGT|ML0831 PUTATIVE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 2316,E(): 1.6e-137, (83.85% identity in 421 aa overlap); and O52199|DGTP_MYCSM|AF027507_2 DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium smegmatis (428 aa),FASTA scores: opt: 1991, E(): 3.4e-117, (73.5% identity in 422 aa overlap). Also highly similar or similar to several deoxyguanosine triphosphate hydrolases e.g. Q9L2E9|SC7A8.09c PUTATIVE DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Streptomyces coelicolor (424 aa),FASTA scores: opt: 1216, E(): 1e-68, (51.05% identity in 425 aa overlap); BAB48544|MLL1093 DGTP TRIPHOSPHOHYDROLASE from Rhizobium loti (Mesorhizobium loti) (404 aa), FASTA scores: opt: 489, E(): 3.1e-23, (33.85% identity in 387 aa overlap); P15723|DGTP_ECOLI|DGT|B0160 from Escherichia coli strain K12 (504 aa), FASTA scores: opt: 173, E(): 0.0022, (31.65% identity in 259 aa overlap); etc. BELONGS TO THE DGTPASE FAMILY.	X2BKT4,P0A541,P0A541	No				P0A541					X2BKT4,P0A541										
NC_002945.3	Mycobrowser_v4	CDS	2613842	2614744	.	-	0	Mb2385c	era		PROBABLE GTP-BINDING PROTEIN ERA	Mb2385c, era, len: 300 aa. Equivalent to Rv2364c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable era,GTP-binding protein, equivalent to Q49768|ERA_MYCLE|ML0631|B1937_F3_102 GTP-BINDING PROTEIN ERA HOMOLOG from Mycobacterium leprae (300 aa) FASTA scores: opt: 1589, E(): 3.4e-88, (81.4% identity in 301 aa overlap). Also highly similar to other GTP-binding proteins e.g. Q9RDF2|ERA_STRCO|SCC77.06 from Streptomyces coelicolor (317 aa), FASTA scores: opt: 1264, E(): 1.1e-68, (64.0% identity in 306 aa overlap); Q9KD52|ERA_BACHD|BH1367|BEX from Bacillus halodurans (304 aa), FASTA scores: opt: 869, (44.8% identity in 297 aa overlap); Q9KIH7|ERA_LACLA|ERAL from Lactococcus lactis (subsp. lactis) (Streptococcus lactis), and Lactococcus lactis (subsp. cremoris) (Streptococcus cremoris) (303 aa), FASTA scores: opt: 781, E(): 9.4e-40, (40.25% identity in 298 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ERA/TRME FAMILY OF GTP-BINDING PROTEINS, ERA SUBFAMILY. Note that previously known as bex.	X2BKV8,P0A563,P0A563	No				P0A563					X2BKV8,P0A563										
NC_002945.3	Mycobrowser_v4	CDS	2603485	2603667	.	-	0	Mb2375c	esxO		putative esat-6 like protein esxo (esat-6 like protein 6)	Mb2375c, esxO, len: 60 aa. Equivalent to 3' end of Rv2346c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 60 aa overlap). esxO,putative ESAT-6 like protein 6, conserved hypotheticalprotein, member of proteins family from Mycobacterium tuberculosis, with O53942|Rv1793|MTV049.15,O05300|Rv1198|MTCI364.10, MTCY15C10.33,P96364|MTCY07H7B.03|Rv1037c|MTCY10G2.12, MTCI364.10, etc. BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Mb2375c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv.	Q7TYS0,A0A1R3Y1C7	No				A0A1R3Y1C7				IPR010310	Q7TYS0										
NC_002945.3	Mycobrowser_v4	CDS	2603651	2605024	.	-	0	Mb2376c	PPE71		PPE FAMILY PROTEIN	Mb2376c, PPE71, len: 457 aa. Equivalent to 5' end of MT2423, len: 621 aa, from Mycobacterium tuberculosis strain CDC1551, (98.475% identity in 459 aa overlap). PPE FAMILY PROTEIN. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, there is a large 8963 bp deletion (RD5) in between Mb2375c and Mb2377c compared to Mycobacterium tuberculosis strain H37Rv. In this region of Mycobacterium bovis two substitutions are present that encode a CDS, Mb2376c, equivalent to that found in Mycobacterium tuberculosis strain CDC1551. The first substitution is of 1218 bp to 350 bp and the second is of 123 bp to 431 bp.	Q7TYR9,A0A1R3Y0W9	No				A0A1R3Y0W9				IPR000030,IPR002989	Q7TYR9										
NC_002945.3	Mycobrowser_v4	CDS	2607744	2609135	.	-	0	Mb2378c	glyS		PROBABLE GLYCYL-tRNA SYNTHETASE GLYS (GLYCINE--tRNA LIGASE) (GLYRS)	Mb2378c, glyS, len: 463 aa. Equivalent to Rv2357c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Probable glyS,glycyl-tRNA synthetase (EC 6.1.1.14), equivalent to Q9CCG4|GLYS|ML0826 PUTATIVE GLYCYL-TRNA SYNTHASE from Mycobacterium leprae (463 aa), FASTA scores: opt: 2898,E(): 1e-179, (90.2% identity in 459 aa overlap). Also highly similar to others e.g. Q9L2H9|SYG_STRCO|SCC121.07c from Streptomyces coelicolor (460 aa), FASTA scores: opt: 2210, E(): 2.9e-135, (68.3% identity in 457 aa overlap); Q9PPZ7|SYG_UREPA|GLYS|UU493 GLYCYL-TRNA SYNTHETASE from Ureaplasma parvum (Ureaplasma urealyticum biotype 1) (473 aa), FASTA scores: opt: 1254, E(): 1.7e-73, (45.25% identity in 462 aa overlap); P75425|SYG_MYCPN|GLYS|MPN354|MP482 GLYCYL-TRNA SYNTHETASE from Mycoplasma pneumoniae (449 aa), FASTA scores: opt: 1074, E(): 6.9e-62, (39.45% identity in 454 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BKU2,P67033,P67033	No				P67033					X2BKU2,P67033										
NC_002945.3	Mycobrowser_v4	CDS	2609317	2609724	.	+	0	Mb2379	smtb		probable transcriptional regulatory protein smtb (probably arsr-family)	Mb2379, -, len: 135 aa. Equivalent to Rv2358, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Probable transcriptional regulator, arsR family, equivalent to Q9CCG5|ML0825 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (140 aa), FASTA scores: opt: 647, E(): 2e-34, (72.9% identity in 140 aa overlap). Also similar to others e.g. BAB48273|MLR0745 Transcriptional regulator from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 185,E(): 3.4e-05, (43.25% identity in 74 aa overlap) (has its N-terminus shorter); P15905|ARR1_ECOLI arsenical resistance operon repressor from Escherichia coli (117 aa), FASTA scores: opt: 164, E(): 8.1e-05, (39.1% identity in 69 aa overlap); etc. Also similar to O53838|Rv0827|MTV043.19c PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 201, E(): 4e-06, (35.7% identity in 98 aa overlap); and O69711|Rv3744|MTV025.092 PUTATIVE REGULATORY PROTEIN from Mycobacterium tuberculosis (120 aa), FASTA scores: opt: 209, E(): 1.2e-06, (35.5 % identity in 93 aa overlap). Contains possible helix-turn-helix motif at aa 72-93 (Score 1103, +2.94 SD). Belongs to the ARSR family of transciptional regulators.	Q7TYR7,A0A1R3Y102	No	regulatory proteins			A0A1R3Y102				IPR001845,IPR011991	Q7TYR7					Rv2358		Rv2358			
NC_002945.3	Mycobrowser_v4	CDS	2609721	2610113	.	+	0	Mb2380	zur		probable zinc uptake regulation protein zur	Mb2380, furB, len: 130 aa. Equivalent to Rv2359,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 130 aa overlap). Probable furB, ferric uptake regulation protein, equivalent to FURB|ML0824|Q9CCG6 PUTATIVE FERRIC UPTAKE REGULATORY PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: opt: 765, E(): 1.7e-43, (86.9% identity in 130 aa overlap). Also highly similar to FERRIC UPTAKE REGULATION PROTEINS e.g. Q9L2H5|SCC121.11 PUTATIVE METAL UPTAKE REGULATION PROTEIN from Streptomyces coelicolor (139 aa),FASTA scores: opt: 547, E(): 3.4e-29, (59.4% identity in 133 aa overlap); P06975|FUR_ECOLI from Escherichia coli (148 aa), FASTA scores: opt: 322, E(): 1.9e-14, (37.9% identity in 132 aa overlap); P45599|FUR_KLEPN FERRIC UPTAKE REGULATION PROTEIN from Klebsiella pneumoniae (155 aa), FASTA scores: opt: 314, E(): 6.7e-14, (36.35% identity in 132 aa overlap); etc. BELONGS TO THE FUR FAMILY.	Q7TYR6,A0A1R3Y106	No	regulatory proteins			A0A1R3Y106				IPR002481,IPR011991	Q7TYR6					Rv2359		Rv2359			
NC_002945.3	Mycobrowser_v4	CDS	2612391	2613845	.	+	0	Mb2384	amiA2		PROBABLE AMIDASE AMIA2 (AMINOHYDROLASE)	Mb2384, amiA2, len: 484 aa. Equivalent to Rv2363,len: 484 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 484 aa overlap). Probable amiA2,amidase (EC 3.5.1.4), highly similar or similar to others e.g. O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 777,E(): 1.1e-38, (35.0% identity in 474 aa overlap); Q55424|AMID_SYNY3|SLL0828 PUTATIVE AMIDASE from Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores: opt: 770, E(): 3e-38, (36.4% identity in 456 aa overlap); Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from Rhodococcus sp. (462 aa), FASTA scores: opt: 701, E(): 3.5e-34, (32.7% identity in 468 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. AMI2_MYCTU|AMIB2|Q11056|Rv1263|MT1301|MTCY50.19c|cy50.19c AMIDASE (462 aa), FASTA scores: opt: 1141, E(): 2.9e-60,(45.4% identity in 454 aa overlap); etc. Contains PS00571 Amidases signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE AMIDASE FAMILY.	X2BK85,P63491,P63491	No				P63491					X2BK85,P63491										
NC_002945.3	Mycobrowser_v4	CDS	2630138	2635186	.	-	0	Mb2401c	mbtE		PEPTIDE SYNTHETASE MBTE (PEPTIDE SYNTHASE)	Mb2401c, mbtE, len: 1682 aa. Equivalent to Rv2380c,len: 1682 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1682 aa overlap). mbtE, peptide synthetase (see citations below), similar in part to several synthases e.g. O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 2635, E(): 1.9e-146, (36.8% identity in 1657 aa overlap); O05647|SNBDE VIRGINIAMYCIN S SYNTHETASE (FRAGMENT) from Streptomyces virginiae (1997 aa) FASTA scores: opt: 2580, E(): 1.6e-143, (40.65% identity in 1163 aa overlap); Q9R9I2|DHBF PROTEIN INVOLVED IN SIDEROPHORE PRODUCTION from Bacillus subtilis (2378 aa), FASTA scores: opt: 2388, E(): 3.6e-132, (33.9% identity in 1579 aa overlap); O68487|ACMB ACTINOMYCIN SYNTHETASE II from Streptomyces chrysomallus (2611 aa),FASTA scores: opt: 2165, E(): 4.9e-119, (35.0% identity in 1634 aa overlap); etc. Equivalent to AAK46743 from Mycobacterium tuberculosis strain CDC1551 (1787 aa) but shorter 105 aa. Contains PS00455 putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7TYQ7	No								IPR000873,IPR001242,IPR006162,IPR009081,IPR010071,IPR020845,IPR025110	Q7TYQ7	A0A1R3Y0Z1									
NC_002945.3	Mycobrowser_v4	CDS	2775107	2775532	.	+	0	Mb2522	vapc38		possible toxin vapc38. contains pin domain.	Mb2522, -, len: 141 aa. Equivalent to Rv2494, len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P95023|EMBL:Z83863|MTCY159.26|Rv2530c (139 aa) FASTA scores: opt: 380 E(): 6.6e-19, (48.0% identity in 125 aa overlap); O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: 287, E(): 1.3e-12, (41.6% identity in 125 aa overlap); AAK46915|MT2605 (strain CDC1551) (139 aa) FASTA scores: opt: 380, E(): 6.6e-19 (48.0% identity in 125 aa overlap); etc.	Q7TYG3	No	virulence, detoxification, adaptation							IPR006226,IPR022907	Q7TYG3	A0A1R3Y1R4				Rv2494		Rv2494			
NC_002945.3	Mycobrowser_v4	CDS	2616987	2618045	.	-	0	Mb2389c	phoH1		PROBABLE PHOH-LIKE PROTEIN PHOH1 (PHOSPHATE STARVATION-INDUCIBLE PROTEIN PSIH)	Mb2389c, phoH1, len: 352 aa. Equivalent to Rv2368c,len: 352 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 352 aa overlap). Probable phoH1,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein, equivalent to Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-LIKE PROTEIN from Mycobacterium leprae (349 aa), FASTA scores: opt: 1952, E(): 4.7e-107, (88.9% identity in 352 aa overlap). Also highly similar to Q9L2L5|SCC117.05 PHOH-LIKE PROTEIN from Streptomyces coelicolor (359 aa), FASTA scores: opt: 1407, E(): 3.6e-75, (63.6% identity in 349 aa overlap); Q9RSY1|DR1988 PHOH-RELATED PROTEIN from Deinococcus radiodurans (380 aa), FASTA scores: opt: 1053, E(): 1.9e-54, (53.3% identity in 349 aa overlap); Q9KD58|PHOH|BH1361 PHOSPHATE STARVATION-INDUCED PROTEIN from Bacillus halodurans (320 aa), FASTA scores: opt: 1019, E(): 1.6e-52, (54.35% identity in 300 aa overlap); P46343|PHOL_BACSU PHOH-LIKE PROTEIN from Bacillus subtilis (319 aa), FASTA scores: opt: 1014, E(): 3.2e-52, (50.8% identity in 303 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOH FAMILY. Note that previously known as phoH.	X2BK92,P0A5S1	No									X2BK92,P0A5S1	P0A5S1									
NC_002945.3	Mycobrowser_v4	CDS	2619824	2620009	.	+	0	Mb2392	PE_PGRS40		pe-pgrs family protein pe_pgrs40	Mb2392, PE_PGRS40, len: 61 aa. Equivalent to Rv2371, len: 61 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 61 aa overlap). Short protein,member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to N-terminal part of others e.g. AAK44356|MT0132 PE_PGRS FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (561 aa), FASTA scores: opt: 217, E( ): 4.9e-08,(69.65% identity in 56 aa overlap); etc.	Q7TYR1	No	PE/PPE							IPR000084	Q7TYR1	A0A1R3Y370				Rv2371		Rv2371			
NC_002945.3	Mycobrowser_v4	CDS	2620910	2622058	.	-	0	Mb2394c	dnaJ2		PROBABLE CHAPERONE PROTEIN DNAJ2	Mb2394c, dnaJ2, len: 382 aa. Equivalent to Rv2373c,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 382 aa overlap). Probable dnaJ2,chaperone protein, equivalent to Q49762|DNJ2_MYCLE|ML0625|B1937_F2_56 CHAPERONE PROTEIN from Mycobacterium leprae (378 aa), FASTA scores: opt: 2301, E(): 1.7e-120, (87.5% identity in 382 aa overlap). Also highly similar to OTHER CHAPERONE PROTEINS DNAJ/DNAJ2 e.g. Q9RDD7|DNJ2_STRCO|SCC77.21c from Streptomyces coelicolor (378 aa), FASTA scores: opt: 1456, E(): 1.2e-73, (54.8% identity in 385 aa overlap); O52164|DNJ2_STRAL from Streptomyces albus (379 aa) FASTA scores: opt: 1378, E(): 2.6e-69, (52.2% identity in 385 aa overlap); Q9S5A3|DNAJ_LISMO from Listeria monocytogenes (377 aa), FASTA scores: opt: 1013, E(): 4.6e-49, (41.3% identity in 385 aa overlap); etc. Also similar to Rv0352|MTCY13E10.12 from Mycobacterium tuberculosis. Contains 1 J domain and 1 CR domain. BELONGS TO THE DNAJ FAMILY.	X2BKA0,P63967	No									X2BKA0,P63967	P63967									
NC_002945.3	Mycobrowser_v4	CDS	2622133	2623164	.	-	0	Mb2395c	hrcA		probable heat shock protein transcriptional repressor hrca	Mb2395c, hrcA, len: 343 aa. Equivalent to Rv2374c,len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 343 aa overlap). Probable hrcA,heat-inducible transcriptional repressor, equivalent to Q9CCN2|HRCA|ML0624 PUTATIVE HEAT-INDUCIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (343 aa), FASTA scores: opt: 1926, E(): 3.9e-107, (89.8% identity in 343 aa overlap). Also highly similar to other heat-inducible transcription repressor proteins e.g. Q9RDD6|HRCA|SCC77.22c from Streptomyces coelicolor (338 aa), FASTA scores: opt: 1227, E(): 1.1e-65, (58.8% identity in 335 aa overlap); O52163|HRCA_STRAL from Streptomyces albus (338 aa), FASTA scores: opt: 1196, E(): 7.7e-64, (56.1% identity in 335 aa overlap); P25499|HRCA_BACSU HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR from Bacillus subtilis (343 aa), FASTA scores: opt: 538,E(): 8.4e-25, (28.9% identity in 325 aa overlap); etc. Almost identical, but conflict at C-terminus, to Q49749|YGRP|B1937_F1_18 PUTATIVE HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR from Mycobacterium leprae (197 aa) FASTA scores: opt: 1126, E(): 6.9e-60, (91.8% identity in 195 aa overlap). BELONGS TO THE HRCA FAMILY.	X2BKW5,P64399	No									X2BKW5,P64399	P64399									
NC_002945.3	Mycobrowser_v4	CDS	2623680	2624186	.	-	0	Mb2397c	cfp2		LOW MOLECULAR WEIGHT ANTIGEN CFP2 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 2) (CFP-2)	Mb2397c, cfp2, len: 168 aa. Equivalent to Rv2376c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). cfp2 (alternate gene name: mtb12), low molecular weight antigen, secreted protein similar to Q49771|MB12_MYCLE|ML0620|B1937_F3_91 LOW MOLECULAR WEIGHT ANTIGEN MTB12 HOMOLOG PRECURSOR from Mycobacterium leprae (167 aa), FASTA scores: opt: 682,E(): 1.7e-32, (65.5% identity in 165 aa overlap). BELONGS TO THE MTB12 FAMILY.	X2BKH3,P0A5P9	No									X2BKH3,P0A5P9	P0A5P9									
NC_002945.3	Mycobrowser_v4	CDS	2624286	2624501	.	-	0	Mb2398c	mbtH		PUTATIVE CONSERVED PROTEIN MBTH	Mb2398c, mbtH, len: 71 aa. Equivalent to Rv2377c,len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 71 aa overlap). Putative mbtH,conserved protein with no function assigned (see first and second citation), similar to hypothetical proteins or proteins found in several gene clusters for biosynthesis or transport of siderophores and other nonribosomally synthesized peptides e.g. Q9Z388|SCE8.11c PUTATIVE SMALL CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (71 aa), FASTA scores: opt: 345, E(): 1.4e-19,(68.2% identity in 66 aa overlap); Q9F8V3|CUMB COUY PROTEIN (probably involved in the biosynthesis of aminocoumarin antibiotic coumermycin A(1)) (see third citation below) from Streptomyces rishiriensis (71 aa),FASTA scores: opt: 329, E(): 2.2e-18, (63.2% identity in 68 aa overlap); Q9F5J2|SIM-CB MBTH-LIKE PROTEIN (probably protein involved in the biosynthesis of aminocoumarin antibiotic coumermycin A(1)) from Streptomyces antibioticus (70 aa), FASTA scores: opt: 308, E(): 8.4e-17, (65.6% identity in 64 aa overlap); Q9FB14 MBTH-LIKE PROTEIN (involved in the biosynthesis of the antitumor drug bleomycin) (see fourth citation below) from Streptomyces verticillus FASTA scores: opt: 220, E(): 8.8e-10, (41.2% identity in 68 aa overlap); etc.	X2BKW6	No									X2BKW6	P59965									
NC_002945.3	Mycobrowser_v4	CDS	2624479	2625774	.	-	0	Mb2399c	mbtG		LYSINE-N-OXYGENASE MBTG (L-LYSINE 6-MONOOXYGENASE) (LYSINE N6-HYDROXYLASE)	Mb2399c, mbtG, len: 431 aa. Equivalent to Rv2378c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). mbtG, lysine-N -oxygenase (hydroxylase) (EC 1.14.13.59) showing some similarity with various proteins including ornithine and lysine-N-oxygenases, e.g. Q9K6Q1|TRKA|BH3677 POTASSIUM UPTAKE PROTEIN from Bacillus halodurans (350 aa), FASTA scores: opt: 153, E(): 0.016, (25.2% identity in 246 aa overlap); P56584|SID1_USTMA L-ORNITHINE 5-MONOOXYGENASE (EC 1.13.12.-) from Ustilago maydis (Smut fungus) (570 aa), FASTA scores: opt: 136, E(): 0.31, (22.85% identity in 127 aa overlap); Q9HHV0|HXYA|VNG6214G MONOOXYGENASE from Halobacterium sp. strain NRC-1 (477 aa), FASTA scores: opt: 119, E(): 3.4, (40.0% identity in 70 aa overlap); O69828|SC1A6.23 PUTATIVE LYSINE N-HYDROXLASE (FRAGMENT) from Streptomyces coelicolor (134 aa), BLAST score: 76 (similarity in part for this one); etc. COFACTORS: FAD (BY SIMILARITY).	X2BKA8,Q7TYQ9	No									X2BKA8,Q7TYQ9	Q7TYQ9									
NC_002945.3	Mycobrowser_v4	CDS	2625771	2630156	.	-	0	Mb2400c	mbtF		PEPTIDE SYNTHETASE MBTF (PEPTIDE SYNTHASE)	Mb2400c, mbtF, len: 1461 aa. Equivalent to Rv2379c,len: 1461 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1461 aa overlap). mbtF, peptide synthetase (see citations below), similar in part to several synthases e.g. O52820|PCZA363.4 PROTEIN from Amycolatopsis orientalis (4077 aa), FASTA scores: opt: 1873, E(): 1.1e-99, (35.55% identity in 1522 aa overlap); O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 1817, E(): 2.1e-96, (33.65% identity in 1463 aa overlap); O52821 PROTEIN SIMILAR TO PEPTIDE SYNTHETASE from Amycolatopsis orientalis (1860 aa) FASTA scores: opt: 1705, E(): 2.9e-90, (34.75% identity in 1344 aa overlap); Q9XCF2|PSTB PUTATIVE PEPTIDE SYNTHETASE (similar to Mycobacterium tuberculosis nrp protein) from Mycobacterium avium (2552 aa), FASTA scores: opt: 1687, E(): 4e-89,(35.45% identity in 1058 aa overlap); Q9ZET7 PEPTIDE SYNTHETASE (FRAGMENT) from Mycobacterium smegmatis (1438 aa), FASTA scores: opt: 1479, E(): 2.5e-77, (30.45% identity in 1507 aa overlap); etc. Contains PS00455 putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7TYQ8	No								IPR000873,IPR001242,IPR009081,IPR010071,IPR020845,IPR025110	Q7TYQ8	A0A1R3Y126									
NC_002945.3	Mycobrowser_v4	CDS	2635326	2638340	.	-	0	Mb2402c	mbtD		POLYKETIDE SYNTHETASE MBTD (POLYKETIDE SYNTHASE)	Mb2402c, mbtD, len: 1004 aa. Equivalent to Rv2381c,len: 1004 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1004 aa overlap). mbtD,polyketide synthase (see citations below), similar in part to several synthases e.g. Q03132|ERY2_SACER|ERYA ERYTHRONOLIDE SYNTHASE, MODULES 3 AND 4 (EC 2.3.1.94) from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa), FASTA scores: opt: 971, E(): 1e-46, (29.35% identity in 1043 aa overlap); Q9F829|MEGAII MEGALOMICIN 6-DEOXYERYTHRONOLIDE B SYNTHASE 2 from Micromonospora megalomicea subsp. nigra (3562 aa), FASTA scores: opt: 787, E(): 2.4e-36, (29.35% identity in 1032 aa overlap); Q9L4W4|NYSB POLYKETIDE SYNTHASE from Streptomyces noursei (3192 aa), FASTA scores: opt: 761, E(): 6.6e-35, (29.55% identity in 1086 aa overlap); O30764|NIDA1 POLYKETIDE SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 aa), FASTA scores: opt: 726, E(): 7.8e-33, (27.3% identity in 1052 aa overlap); etc. Contains PS00012 Phosphopantetheine attachment site.	Q7TYQ6	No								IPR001227,IPR006162,IPR009081,IPR013968,IPR014043,IPR016035,IPR016036,IPR016040,IPR020801	Q7TYQ6	A0A1R3Y380									
NC_002945.3	Mycobrowser_v4	CDS	2638340	2639674	.	-	0	Mb2403c	mbtC		POLYKETIDE SYNTHETASE MBTC (POLYKETIDE SYNTHASE)	Mb2403c, mbtC, len: 444 aa. Equivalent to Rv2382c,len: 444 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 444 aa overlap). mbtC, polyketide synthase (see citations below), similar in part to several synthases e.g. Q9F7T9 AVERMECTIN POLYKETIDE SYNTHASE (FRAGMENT) from Streptomyces avermitilis (3626 aa), FASTA scores: opt: 1458, E(): 7e-82, (50.65% identity in 446 aa overlap); AAG23264|SPNA POLYKETIDE SYNTHASE LOADING AND EXTENDER MODULE 1 from Saccharopolyspora spinosa (2595 aa) FASTA scores: opt: 1441, E(): 6e-81, (49.1% identity in 446 aa overlap); O33954|TYLG TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 from Streptomyces fradiae (4472 aa) FASTA scores: opt: 1439, E(): 1.2e-80, (51.0% identity in 447 aa overlap); O30764|NIDA1 POLYKETIDE SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 aa) FASTA scores: opt: 1432, E(): 3.3e-80, (50.9% identity in 442 aa overlap); etc.	Q7TYQ5	No								IPR014030,IPR014031,IPR016038,IPR016039	Q7TYQ5	A0A1R3Y1U7									
NC_002945.3	Mycobrowser_v4	CDS	2639664	2643908	.	-	0	Mb2404c	mbtB		PHENYLOXAZOLINE SYNTHASE MBTB (PHENYLOXAZOLINE SYNTHETASE)	Mb2404c, mbtB, len: 1414 aa. Equivalent to Rv2383c,len: 1414 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1414 aa overlap). mbtB,phenyloxazoline synthase (see citations below), similar to the N-terminal region of several synthetases e.g. Q9EWP5|SC4C2.17 PUTATIVE NON-RIBOSOMAL PEPTIDE SYNTHASE from Streptomyces coelicolor (2229 aa), FASTA scores: opt: 2878, E(): 4.1e-156, (46.85% identity in 1138 aa overlap); Q9Z399|IRP2 YERSINIABACTIN BIOSYNTHETIC from Yersinia pestis (2041 aa), FASTA scores: opt: 2297, E(): 5.3e-123,(38.55% identity in 1069 aa overlap); P48633|HMP2_YEREN|IRP2 HIGH-MOLECULAR-WEIGHT PROTEIN 2 (MAY BE INVOLVED IN THE NONRIBOSOMAL SYNTHESIS OF SMALL PEPTIDES) from Yersinia enterocolitica (2035 aa), FASTA scores: opt: 2275, E(): 9.4e-122, (38.45% identity in 1069 aa overlap); O85739|PCHE|PA4226 DIHYDROAERUGINOIC ACID SYNTHETASE from Pseudomonas aeruginosa (1438 aa) FASTA scores: opt: 2236, E(): 1.2e-119, (38.2% identity in 1330 aa overlap); Q9RFM8|PCHE PYOCHELIN SYNTHETASE from Pseudomonas aeruginosa (1438 aa), FASTA scores: opt: 2229,E(): 3e-119, (38.0% identity in 1329 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature,and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	X2BKB5,Q7TYQ4	No									X2BKB5,Q7TYQ4	Q7TYQ4									
NC_002945.3	Mycobrowser_v4	CDS	2644007	2645704	.	+	0	Mb2405	mbtA		BIFUNCTIONAL ENZYME MBTA: SALICYL-AMP LIGASE (SAL-AMP LIGASE) + SALICYL-S-ArCP SYNTHETASE	Mb2405, mbtA, len: 565 aa. Equivalent to Rv2384,len: 565 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 565 aa overlap). mbtA, bifunctional enzyme, including salicyl-AMP ligase (Sal-AMP ligase) (EC 6.-.-.-) and salicyl-S-ArCP synthetase (see first and second citations below), highly similar to other ligases e.g. Q9F638|MXCE from Stigmatella aurantiaca 2,3-DHBA-AMP ligase (protein involved in the biosynthesis of 2,3-dihydroxybenzoic acid, contains the AMP binding signature) (543 aa), FASTA scores: opt: 1683, E(): 2.8e-90, (48.25% identity in 545 aa overlap) (see third citation below); P40871|DHBE_BACSU|ENTE 2,3-DIHYDROXYBENZOATE-AMP LIGASE (EC 6.3.2.-) from Bacillus subtilis (539 aa), FASTA scores: opt: 1569, E(): 1.2e-83, (44.9% identity in 532 aa overlap); O07899|VIBE_VIBCHVC0772 VIBRIOBACTIN-SPECIFIC 2,3-DIHYDROXYBENZOATE-AMP LIGASE from Vibrio cholerae (543 aa), FASTA scores: opt: 1457, E(): 3.7e-77, (44.6% identity in 545 aa overlap); etc. Also similar to P95819|SNBA PRISTINAMYCIN I SYNTHETASE I from Streptomyces pristinaespiralis (582 aa), FASTA scores: opt: 1532, E(): 1.7e-81, (46.35% identity in 548 aa overlap); and Q9RFM9|PCHD SALICYL-AMP LIGASE from Pseudomonas aeruginosa (547 aa), FASTA scores: opt: 1415, E(): 1e-74, (45.95% identity in 533 aa overlap). Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	Q7TYQ3	No	lipid metabolism							IPR000873,IPR025110	Q7TYQ3	A0A1R3Y1F4				Rv2384		Rv2384			
NC_002945.3	Mycobrowser_v4	CDS	2645800	2646720	.	+	0	Mb2406	mbtJ		PUTATIVE ACETYL HYDROLASE MBTJ	Mb2406, mbtJ, len: 306 aa. Equivalent to Rv2385,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 306 aa overlap). Putative mbtJ, acetyl hydrolase (EC 3.1.1.-) (see citations below), showing some similarity with various hydrolases including acetyl hydrolases e.g. Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE/ESTERASE from Mycobacterium leprae (335 aa),FASTA scores: opt: 449, E(): 6.7e-21, (33.85% identity in 313 aa overlap); AAK47950|MT3591 Esterase from M. tuberculosis strain CDC1551 (327 aa), FASTA scores: opt: 469, E(): 3.6e-22, (35% identity in 283 aa overlap); Q9X8J4|SCE9.22 PUTATIVE ESTERASE from Streptomyces coelicolor (266 aa), FASTA scores: opt: 430,E(): 8.5e-20,(38% identity in 245 aa overlap); Q01109|BAH_STRHY ACETYL-HYDROLASE (EC 3.1.1.-) from Streptomyces hygroscopicus (299 aa), FASTA scores: opt: 420, E(): 4e-19, (35.1% identity in 265 aa overlap). Equivalent to AAK46748 from Mycobacterium tuberculosis strain CDC1551 (327 aa) but shorter 21 aa. Note that previously known as lipK.	Q7TYQ2	No	lipid metabolism							IPR013094	Q7TYQ2	A0A1R3Y107				Rv2385		Rv2385			
NC_002945.3	Mycobrowser_v4	CDS	2646724	2648076	.	-	0	Mb2407c	mbtI		isochorismate synthase mbti	Mb2407c, mbtI, len: 450 aa. Equivalent to Rv2386c,len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 450 aa overlap). Putative mbtI,isochorismate synthase (see citations below), similar to Q9X9I8|IRP9 SALICYLATE SYNTHETASE from Yersinia enterocolitica (434 aa), FASTA scores: opt: 887, E(): 7.5e-48, (37.45% identity in 422 aa overlap); and similar in C-terminal region to many anthranilate synthases component I (EC 4.1.3.27) e.g. Q9Z4W7|TRPE_STRCO|SCE8.07c from Streptomyces coelicolor (511 aa), FASTA scores: opt: 509, E(): 3e-24, (40.4% identity in 255 aa overlap); P33975|TRPE_HALVO from Halobacterium volcanii (Haloferax volcanii) (523 aa) FASTA scores: opt: 488, E(): 6.2e-23,(34.2% identity in 298 aa overlap); and similar to Q08653|TRPE_THEMA|TM0142 ANTHRANILATE SYNTHASE COMPONENT I from Thermotoga maritima (461 aa), FASTA scores: opt: 478,E(): 2.3e-22, (28.4% identity in 440 aa overlap); etc. COULD BE BELONG TO THE ANTHRANILATE SYNTHASE COMPONENT I FAMILY. Note that previously known as trpE2, an anthranilate synthase component I (EC 4.1.3.27).	X2BKI5,Q7TYQ1	No									X2BKI5,Q7TYQ1	Q7TYQ1									
NC_002945.3	Mycobrowser_v4	CDS	2650086	2651213	.	-	0	Mb2409c	hemN		PROBABLE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE HEMN (COPROPORPHYRINOGENASE) (COPROGEN OXIDASE)	Mb2409c, hemN, len: 375 aa. Equivalent to Rv2388c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 375 aa overlap). Probable hemN,oxygen-independent coproporphyrinogen III oxidases (EC 1.3.3.-), highly similar to many PUTATIVE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASES e.g. Q9RDD2|SCC77.26 from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1358, E(): 1.5e-76, (56.55% identity in 382 aa overlap); BAB51237|MLR4627 from Rhizobium loti (Mesorhizobium loti) (392 aa), FASTA scores: opt: 696,E(): 1.1e-35, (36.8% identity in 383 aa overlap); Q9KUR0|VC0455 from Vibrio cholerae (391 aa), FASTA scores: opt: 691, 2.2e-35, (32.65% identity in 386 aa overlap); P54304|HEMN_BACSU from Bacillus subtilis (366 aa), FASTA scores: opt: 668 , E(): 5.6e-34; (34.9% identity in 327 aa overlap); etc. Equivalent to AAK46752 from Mycobacterium tuberculosis strain CDC1551 (390 aa) but shorter 375 aa. BELONGS TO THE ANAEROBIC COPROPORPHYRINOGEN III OXIDASE FAMILY.	Q7TYP9	No								IPR004559,IPR006638,IPR007197,IPR023404	Q7TYP9	A0A1R3Y134									
NC_002945.3	Mycobrowser_v4	CDS	2651319	2651783	.	-	0	Mb2410c	rpfD		PROBABLE RESUSCITATION-PROMOTING FACTOR RPFD	Mb2410c, rpfD, len: 154 aa. Equivalent to Rv2389c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Probable rpfD,resuscitation-promoting factor. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citation below). Similar to others from Mycobacterium tuberculosis e.g. O07747|Rv1884c|MTCY180.34|RPFC PROBABLE RESUSCITATION-PROMOTING FACTOR from Mycobacterium tuberculosis (176 aa), FASTA scores: opt: 382, E(): 2.3e-17, (55.45% identity in 101 aa overlap); etc. Also similarity with Q9CBF8|ML2030 HYPOTHETICAL PROTEIN from Mycobacterium leprae (157 aa), FASTA scores: opt: 397,E(): 2.4e-18, (47.95% identity in 121 aa overlap); Q9F2Q2|SCE41.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 341,E(): 1.1e-14, (40.45% identity in 131 aa overlap); and O86308|Z96935|MLRPF_1 RPF PROTEIN PRECURSOR from Micrococcus luteus (220 aa), FASTA scores: opt: 301, E(): 3.6e-12, (39.4% identity in 132 aa overlap). Contains a secretory signal sequence in N-terminus. Supposed acts at very low concentration.	Q7TYP8	No								IPR010618,IPR023346	Q7TYP8	A0A1R3Y0Z9									
NC_002945.3	Mycobrowser_v4	CDS	2652750	2654441	.	+	0	Mb2412	sira		ferredoxin-dependent sulfite reductase sira	Mb2412, nirA, len: 563 aa. Equivalent to Rv2391,len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 563 aa overlap). Probable nirA,ferredoxin-dependant nitrite reductase (EC 1.7.7.1),similar to many nitrate reductases e.g. CAC33947|SCBAC1A6.26c Putative nitrite/sulphite reductase from Streptomyces coelicolor (565 aa), FASTA scores: opt: 2335, E(): 1.2e-137, (60.1% identity in 567 aa overlap); Q9RZD6|DRA0013 FERREDOXIN-NITRITE REDUCTASE from Deinococcus radiodurans (563 aa), FASTA scores: opt: 1141,E(): 2.2e-63, (39.6% identity in 533 aa overlap); Q59656|NIRA (D31732|PEENIRNRT_1) ferredoxin-dependant* NITRITE REDUCTASE (*: see citation below) from Plectonema boryanum (654 aa), FASTA scores: opt: 805, E(): 1.9e-42,(31.7% identity in 517 aa overlap); Q55366|NIRA|SLR0898 FERREDOXIN-NITRITE REDUCTASE from Synechocystis sp. strain PCC 6803 (502 aa), FASTA scores: opt: 799, E(): 3.7e-42,(32.3% identity in 517 aa overlap). Highly similar (only in N-terminal part because shortened protein (fragment) owing to an IS900 insertion) to Q9K541|NIRA NITRATE REDUCTASE (FRAGMENT) from Mycobacterium paratuberculosis (198 aa), FASTA scores: opt: 798, E(): 2.1e-42, (65.4% identity in 182 aa overlap).	X2BKZ0,Q7TYP6	No	intermediary metabolism and respiration								X2BKZ0,Q7TYP6	Q7TYP6				Rv2391		Rv2391			
NC_002945.3	Mycobrowser_v4	CDS	2654438	2655202	.	+	0	Mb2413	cysH		probable 3'-phosphoadenosine 5'-phosphosulfate reductase cysh (paps reductase, thioredoxin dep.) (padops reductase) (3'-phosphoadenylylsulfate reductase) (paps sulfotransferase)	Mb2413, cysH, len: 254 aa. Equivalent to Rv2392,len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Probable cysH,3'-phosphoadenosine 5'-phosphosulfate reductase (EC 1.8.4.8), similar to many e.g. P94498|O34620|CYH1_BACSU|CYSH from Bacillus subtilis (233 aa), FASTA scores: opt: 618, E(): 8.1e-32, (46.5% identity in 202 aa overlap); Q9KCT3|CYSH|BH1486 from Bacillus halodurans (231 aa), FASTA scores: opt: 560, E(): 3.6e-28,(41.3% identity in 230 aa overlap); P56860|CYSH_DEIRA from Deinococcus radiodurans (255 aa), FASTA scores: opt: 489,E(): 1.1e-23, (44.7% identity in 190 aa overlap); etc. BELONGS TO THE PAPS REDUCTASE FAMILY and CYSH SUBFAMILY. Note that operon cysA-cysW-cysT-subI, probably involved in sulfate transport, is near this putative ORF.	X2BKC9,P65669	No	intermediary metabolism and respiration								X2BKC9,P65669	P65669				Rv2392		Rv2392			
NC_002945.3	Mycobrowser_v4	CDS	2802582	2804060	.	+	0	Mb2548	PE26		pe family protein pe26	Mb2548, PE26, len: 492 aa. Equivalent to Rv2519,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Member of the M. tuberculosis PE family, highly similar to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543 aa),FASTA scores: opt: 848, E(): 3e-30, (39.55% identity in 445 aa overlap).	Q7TYE2	No	PE/PPE							IPR000084,IPR001969	Q7TYE2	A0A1R3Y1E2				Rv2519		Rv2519			
NC_002945.3	Mycobrowser_v4	CDS	2655199	2656044	.	+	0	Mb2414	che1		ferrochelatase che1	Mb2414, -, len: 281 aa. Equivalent to Rv2393, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 281 aa overlap). Conserved hypothetical protein, with some similarity to Q9L2E8|SC7A8.10c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (274 aa), FASTA scores: opt: 407,E(): 2.8e-18, (37% identity in 246 aa overlap); CAC38793|SCI39.05 Conserved hypothetical protein from Streptomyces coelicolor (305 aa), FASTA scores: opt: 394,E(): 2e-17, (35.0% identity in 251 aa overlap); AAK44492|MT0272 Chalcone/stilbene synthase family protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 350, E(): 9.2e-15, (34.0% identity in 235 aa overlap); P95216|Rv0259c|MTCY06A4.03c|Z86089 hypothetical protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 345, E(): 1.9e-14,(33.6% identity in 235 aa overlap).	Q7TYP5	No	intermediary metabolism and respiration							IPR002762	Q7TYP5	A0A1R3Y1G4				Rv2393		Rv2393			
NC_002945.3	Mycobrowser_v4	CDS	2656081	2658012	.	+	0	Mb2415	ggtB		PROBABLE GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR GGTB (GAMMA-GLUTAMYLTRANSFERASE) (GLUTAMYL TRANSPEPTIDASE)	Mb2415, ggtB, len: 643 aa. Equivalent to Rv2394,len: 643 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 643 aa overlap). Probable ggtB,gamma-glutamyltranspeptidase precursor (EC 2.3.2.2),similar to many e.g. Q9KVF2|VC0194 from Vibrio cholerae (588 aa), FASTA scores: opt: 943, E(): 7.5e-47, (40.0% identity in 597 aa overlap); O69935|SC3C8.26 from Streptomyces coelicolor (603 aa), FASTA scores: opt: 822,E(): 7.2e-40, (33.6% identity in 622 aa overlap); P54422|GGT_BACSU from Bacillus subtilis (587 aa) FASTA scores: opt: 491, E(): 8.2e-21, (33.4% identity in 574 aa overlap); etc. Has potential signal peptide and appropriately positioned prokaryotic lipoprotein attachment site (PS00013).	Q7TYP4	No	intermediary metabolism and respiration							IPR000101	Q7TYP4	A0A1R3Y119				Rv2394		Rv2394			
NC_002945.3	Mycobrowser_v4	CDS	2660296	2660511	.	+	0	Mb2417A	aprA		Acid and phagosome regulated protein A AprA	Mb2417A, len: 71 aa. Equivalent to Rv2395A len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). AprA, acid and phagosome regulated protein A, restricted to M. tuberculosis complex. Note completely overlapped by sRNA mcr7.	X2BKD5	No	conserved hypotheticals								X2BKD5	A0A1R3Y138				Rv2395A		Rv2395A			
NC_002945.3	Mycobrowser_v4	CDS	2660623	2660787	.	+	0	Mb2417B	aprB		Acid and phagosome regulated protein B AprB	Mb2417B, len: 54 aa. Equivalent to Rv2395B len: 54 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 54 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). AprB, acid and phagosome regulated protein B, restricted to M. tuberculosis complex.	X2BKY6	No	conserved hypotheticals								X2BKY6	A0A1R3Y143				Rv2395B		Rv2395B			
NC_002945.3	Mycobrowser_v4	CDS	2660871	2661953	.	+	0	Mb2418	PE_PGRS41		pe-pgrs family protein pe_pgrs41	Mb2418, PE_PGRS41, len: 360 aa. Equivalent to Rv2396, len: 361 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 361 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. AAK47132|MT2812 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (454 aa), FASTA scores: opt: 1256, E(): 2.4e-44, (56.0% identity in 377 aa overlap); AAK46139|MT1866 PE_PGRS FAMILY PROTEIN from M. tuberculosis strain CDC1551 (491 aa), FASTA scores: opt: 1250, E(): 4.4e-44, (57.8% identity in 372 aa overlap); Y278_MYCTU|Rv0278C|MTV035.06c HYPOTHETICAL PE-PGRS FAMILY PROTEIN (957 aa), FASTA scores: opt: 1253, E(): 5.2e-44,(55.5% identity in 400 aa overlap); P71664|Rv1396c|MTCY21B4.13c HYPOTHETICAL GLYCINE-RICH 47.9 KDA PROTEIN (576 aa), FASTA scores: opt: 1236, E(): 1.8e-43, (55.55% identity in 402 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (gcc-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa).	Q7TYP1	No								IPR000084	Q7TYP1	A0A1R3Y109									
NC_002945.3	Mycobrowser_v4	CDS	2661978	2663033	.	-	0	Mb2419c	cysA1		sulfate-transport atp-binding protein abc transporter cysa1	Mb2419c, cysA1, len: 351 aa. Equivalent to Rv2397c,len: 351 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 351 aa overlap). Probable cysA1,sulfate-transport ATP-binding protein ABC transporter (see citations below), similar to OTHER SULFATE ABC TRANSPORTER ATP-BINDING PROTEINS e.g. P14788|CYSA_SYNP7 from Synechococcus sp. (344 aa), FASTA scores: opt: 1112, E(): 2.6e-56, (54.6% identity in 328 aa overlap); P74548|CYSA_SYNY3 from Synechocystis sp. (355 aa), FASTA scores: opt: 1063, E(): 1.7e-53, (51.9% identity in 343 aa overlap); Q9I6L0|CYSA|PA0280 from Pseudomonas aeruginosa (329 aa), FASTA scores: opt: 987, E(): 3.3e-49, (49.2% identity in 339 aa overlap); etc. Also similar to many ATP-binding proteins from Mycobacterium tuberculosis e.g. Rv2038c, Rv1238, Rv2832c, etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that previously known as cysA.	X2BKK1,P0A4W3	No									X2BKK1,P0A4W3	P0A4W3									
NC_002945.3	Mycobrowser_v4	CDS	2663050	2663868	.	-	0	Mb2420c	cysW		PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYSW	Mb2420c, cysW, len: 272 aa. Equivalent to Rv2398c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 272 aa overlap). Probable cysW,sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. Q9K877|CYSW|BH3129 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (287 aa), FASTA scores: opt: 765, E(): 4.1e-40, (43.8% identity in 249 aa overlap); P27370|CYSW_SYNP7 sulfate transport system (permease) protein from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (286 aa), FASTA scores: opt: 757, E(): 1.3e-39, (44.3% identity in 264 aa overlap); Q9I6K9|CYSW|PA0281 SULFATE TRANSPORT PROTEIN from Pseudomonas aeruginosa (289 aa), FASTA scores: opt: 753,E(): 2.3e-39, (44.4% identity in 250 aa overlap); P16702|P76534|CYSW_ECOLI SULFATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (291 aa), FASTA scores: opt: 633,E(): 5.7e-32, (38.2% identity in 267 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature. SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS and BELONGS TO THE CYSTW SUBFAMILY.	Q7TYP0	No								IPR000515,IPR005667,IPR011866	Q7TYP0	A0A1R3Y1W5									
NC_002945.3	Mycobrowser_v4	CDS	2663865	2664716	.	-	0	Mb2421c	cysT		PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYST	Mb2421c, cysT, len: 283 aa. Equivalent to Rv2399c,len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Probable cysT,sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. BAB48989|MLR1667 PERMEASE PROTEIN OF SULFATE ABC TRANSPORTER from Rhizobium loti (283 aa), FASTA scores: opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa overlap); Q9K878|CYST|BH3128 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (279 aa), FASTA scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa overlap); P16701|CYST_ECOLI|CYSU|CYST|B2424 from Escherichia coli (277 aa), FASTA scores: opt: 669, E(): 1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CYSTW SUBFAMILY.	Q7TYN9	No								IPR000515,IPR005667,IPR011865	Q7TYN9	A0A1R3Y1B0									
NC_002945.3	Mycobrowser_v4	CDS	2664713	2665783	.	-	0	Mb2422c	subI		PROBABLE SULFATE-BINDING LIPOPROTEIN SUBI	Mb2422c, subI, len: 356 aa. Equivalent to Rv2400c,len: 356 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 356 aa overlap). Probable subI,sulfate-binding lipoprotein component of sulfate transport system (see citations below), equivalent to Q9CCN3|SUBI|ML0615 (alias Q49748|B1937_F1_11, 358 aa) PUTATIVE SULPHATE-BINDING PROTEIN from Mycobacterium leprae (348 aa), FASTA scores: opt: 1775, E(): 2.3e-102,(76.45% identity in 340 aa overlap). Also similar to others and other substrate-binding proteins e.g. P27366|SUBI_SYNP7|SBPA SULFATE-BINDING PROTEIN PRECURSOR from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (350 aa), FASTA scores: opt: 703, E(): 4.6e-36, (35.6% identity in 351 aa overlap); Q9I6K7|SBP|PA0283 SULFATE-BINDING PROTEIN PRECURSOR from Pseudomonas aeruginosa (332 aa), FASTA scores: opt: 591, E(): 3.7e-29,(36.9% identity in 317 aa overlap); CAC49112|SMB21133 PUTATIVE SULFATE UPTAKE ABC TRANSPORTER PERIPLASMIC SOLUTE-BINDING PROTEIN PRECURSOR from Rhizobium meliloti (Sinorhizobium meliloti) (341 aa), FASTA scores: opt: 569,E(): 8.8e-28, (36.15% identity in 321 aa overlap); etc. BELONGS TO THE PROKARYOTIC SULFATE BINDING PROTEIN FAMILY.	Q7TYN8	No								IPR005669	Q7TYN8	A0A1R3Y1G6									
NC_002945.3	Mycobrowser_v4	CDS	4282801	4285044	.	+	0	Mb3900	eccca1		esx conserved component eccca1. esx-1 type vii secretion system protein. possible transmembrane protein.	Mb3900, -, len: 747 aa. Equivalent to Rv3870, len: 747 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 747 aa overlap). Possible conserved membrane protein, equivalent to O33087|ML0053|MLCB628.16c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (744 aa), FASTA scores: opt: 4333, E(): 0, (85.4% identity in 746 aa overlap); and similar to N-terminal end of others e.g. Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 1003, E(): 1e-52,(33.65% identity in 725 aa overlap); O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1078, E(): 3e-57, (35.4% identity in 774 aa overlap); P71068|YUKA YUKA PROTEIN from Bacillus subtilis (1207 aa) FASTA scores: opt: 529, E(): 4.3e-24,(26.1% identity in 636 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),FASTA scores: opt: 455, E(): 1.5e-19, (27.1% identity in 734 aa overlap); etc. Also similar to N-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 982,E(): 1.9e-51, (33.8% identity in 719 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 761, E(): 4.1e-38, (38.2% identity in 746 aa overlap); O53935|Rv1784|MTV049.06 (932 aa), FASTA scores: opt: 547,E(): 2.8e-25, (36.25% identity in 276 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in downstream ORF MTV027.06.	Q7TVG6	No	cell wall and cell processes							IPR002543,IPR023836,IPR027417	Q7TVG6	A0A1R3Y5H3				Rv3870		Rv3870			
NC_002945.3	Mycobrowser_v4	CDS	2668604	2669359	.	-	0	Mb2426c	lppR		PROBABLE CONSERVED LIPOPROTEIN LPPR	Mb2426c, lppR, len: 251 aa. Equivalent to Rv2403c,len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 251 aa overlap). Probable lppR,conserved lipoprotein, with weak similarity with MYCOBACTERIAL SERINE/THREONINE PROTEIN KINASES (EC 2.7.1.-) e.g. AAK45563|MT1304 from Mycobacterium tuberculosis strain CDC1551 (626 aa), FASTA scores: opt: 186, E(): 0.00023, (24.4% identity in 238 aa overlap), and the C-terminal part of Q11053|Rv1266c|MTCY50.16|PKNH_MYCTU from Mycobacterium tuberculosis (626 aa), FASTA scores: opt: 185, E()= 0.00027, (24.35% identity in 238 aa overlap). Has signal peptide and appropriate positioned prokaryotic lipoprotein attachment site (PS00013). Could belong to the SER/THR FAMILY of protein kinases.	Q7TYN4	No								IPR026954	Q7TYN4	A0A1R3Y147									
NC_002945.3	Mycobrowser_v4	CDS	2669356	2671317	.	-	0	Mb2427c	lepA		PROBABLE GTP-BINDING PROTEIN LEPA (GTP-BINDING ELONGATION FACTOR)	Mb2427c, lepA, len: 653 aa. Equivalent to Rv2404c,len: 653 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 653 aa overlap). Probable lepA,GTP-binding protein (a protein of unknown function, but apparently with membrane-related functions and very similar to protein synthesis elongation factors; see citations below). Equivalent to P53530|LEPA_MYCLE|ML0611|B1937_F3_81 GTP-BINDING PROTEIN from Mycobacterium leprae (646 aa), FASTA scores: opt: 3610, E(): 1.2e-205, (88.0% identity in 649 aa overlap). Also highly similar to many GTP-BINDING PROTEINS LEPA e.g. Q9RDC9|LEPA_STRCO|SCC77.29c from Streptomyces coelicolor (622 aa), FASTA scores: opt: 3046, E(): 2.3e-172, (74.3% identity in 626 aa overlap); P37949|LEPA_BACSU from B. subtilis (612 aa), FASTA scores: opt: 2430, E(): 5.3e-136,(58.7% identity in 610 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00301 GTP-binding elongation factors signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, LEPA SUBFAMILY.	X2BKZ6,P65270	No									X2BKZ6,P65270	P65270									
NC_002945.3	Mycobrowser_v4	CDS	2674201	2674920	.	+	0	Mb2431	PE24		possible pe family-related protein pe24	Mb2431, PE24, len: 239 aa. Equivalent to Rv2408,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possibly a member of PE family, similar to AAK46440|MT2159 from Mycobacterium tuberculosis strain CDC1551 (491 aa) FASTA scores: opt: 269, E(): 5.4e-08, (38.45% identity in 156 aa overlap) and AAK45466|MT1209 from Mycobacterium tuberculosis strain CDC1551 (308 aa), FASTA scores: opt: 265, E(): 6.3e-08,(36.0% identity in 197 aa overlap).	Q7TYN0	No	PE/PPE							IPR000084	Q7TYN0	A0A1R3Y1C0				Rv2408		Rv2408			
NC_002945.3	Mycobrowser_v4	CDS	2678259	2678519	.	+	0	Mb2435	rpsT		30s ribosomal protein s20 rpst	Mb2435, rpsT, len: 86 aa. Equivalent to Rv2412,len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Probable rpsT, 30s ribosomal protein s20, equivalent to O33132|RS20_MYCLE|L0604|MLCL536.06 30S RIBOSOMAL PROTEIN S20 from Mycobacterium leprae (86 aa), FASTA scores: opt: 456, E(): 4.6e-24, (87.20% identity in 86 aa overlap). Also highly similar or similar to others e.g. Q9RDM3|RPST|SCC123.01 30S RIBOSOMAL PROTEIN S20 from Streptomyces coelicolor (88 aa), FASTA scores: opt: 363,E(): 7.1e-18, (70.95% identity in 86 aa overlap); Q9KD79|RPST|BH1339 RIBOSOMAL PROTEIN S20 (BS20) from Bacillus halodurans (91 aa), FASTA scores: opt: 252, E(): 1.8e-10, (49.4% identity in 85 aa overlap); P02378|RS20_ECOLI 30s ribosomal protein s20 from Escherichia coli (86 aa), FASTA scores: opt: 210, E(): 1e-07, (42.4% identity in 85 aa overlap); etc. BELONGS TO THE S20P FAMILY OF RIBOSOMAL PROTEINS.	X2BL34,P66506	No	information pathways								X2BL34,P66506	P66506				Rv2412		Rv2412			
NC_002945.3	Mycobrowser_v4	CDS	2696130	2696429	.	-	0	Mb2457c	PE25		pe family protein pe25	Mb2457c, PE25, len: 99 aa. Equivalent to Rv2431c,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below), similar to others e.g. AAK47158|MT2839 from Mycobacterium tuberculosis (275 aa) FASTA scores: opt: 194, E(): 2.5e-06, (40.0% identity in 95 aa overlap); etc.	Q7TYL3	No								IPR000084	Q7TYL3	A0A1R3Y179									
NC_002945.3	Mycobrowser_v4	CDS	2682309	2683535	.	-	0	Mb2439c	eis		enhanced intracellular survival protein eis,gcn5-related n-acetyltransferase	Mb2439c, -, len: 408 aa. Equivalent to Rv2416c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 408 aa overlap). Conserved hypothetical protein, sharing similarity with Q9F309|SCC80.10 HYPOTHETICAL 44.7 KDA PROTEIN from Streptomyces coelicolor (413 aa), FASTA scores: opt: 382, E(): 1e-16, (31.45% identity in 407 aa overlap); Q9K4F4|SCD66.23 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (418 aa), FASTA scores: opt: 238, E(): 1.3e-07, (36.5% identity in 364 aa overlap): and Q54238|G1139577|ORF5 hypothetical protein from Streptomyces griseus (416 aa), FASTA scores: opt: 237, E(): 1.5e-07, (34.0 identity in 423 aa overlap).	X2BKM2,P59772	No	virulence, detoxification, adaptation								X2BKM2,P59772	P59772				Rv2416c		Rv2416c			
NC_002945.3	Mycobrowser_v4	CDS	2706410	2707849	.	-	0	Mb2467c	obg		PROBABLE GTP1/OBG-FAMILY GTP-BINDING PROTEIN OBG	Mb2467c, obg, len: 479 aa. Equivalent to Rv2440c,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Probable obg,nucleotide-binding protein, equivalent to Q9CBZ4|ML1465 GTP1/OBG-FAMILY GTP-BINDING PROTEIN from Mycobacterium leprae (478 aa), FASTA scores: opt: 1328, E(): 8.4e-70,(58.9% identity in 479 aa overlap). Also highly similar to others e.g. P95722|OBG GTP-BINDING PROTEIN from Streptomyces coelicolor (478 aa), FASTA scores: opt: 1311,E(): 8.2e-69, (60.7% identity in 476 aa overlap); P20964|OBG_BACSU SPO0B-ASSOCIATED GTP-BINDING PROTEIN from Bacillus subtilis (428 aa), FASTA scores: opt: 1006, E(): 3.9e-51, (42.9% identity in 436 aa overlap); Q9KDK0|OBG|BH1213 GTP-BINDING PROTEIN INVOLVED IN INITIATION OF SPORULATION from Bacillus halodurans (427 aa), FASTA scores: opt: 978, E(): 1.7e-49, (41.95% identity in 436 aa overlap); etc. Highly similar (identical but shorter 5 aa) to AAK46813|MT2516 GTP-BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551 (484 aa), FASTA scores: opt: 3205, E(): 7.9e-179,(100% identity in 479 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE GTP1/OBG FAMILY.	X2BL33,Q7TYK5	No									X2BL33,Q7TYK5	Q7TYK5									
NC_002945.3	Mycobrowser_v4	CDS	2687268	2687540	.	+	0	Mb2445	Mb2445		HYPOTHETICAL PROTEIN	Mb2445, -, len: 90 aa. Equivalent to Rv2422, len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). Hypothetical unknown protein.	Q7TYM0	No	conserved hypotheticals								Q7TYM0	A0A1R3Y160				Rv2422		Rv2422			
NC_002945.3	Mycobrowser_v4	CDS	2685313	2685984	.	-	0	Mb2442c	gpgp		glucosyl-3-phosphoglycerate phosphatase gpgp	Mb2442c, -, len: 223 aa. Equivalent to Rv2419c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 223 aa overlap). Probable phosphoglycerate mutase (EC 5.4.2.1), equivalent to Q9CC00|ML1452 POSSIBLE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (224 aa), FASTA scores: opt: 1206,E(): 8.8e-68, (80.35% identity in 224 aa overlap). Also highly similar to Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 431, E(): 9.4e-20, (40.85% identity in 213 aa overlap); and similar to others e.g. Q9RVD2|DR1097 from Deinococcus radiodurans (232 aa), FASTA scores: opt: 291, E(): 4.6e-11, (39.3% identity in 173 aa overlap); etc. Some similarity to Q10512|Rv2228c|Y019_MYCTU|MT2287|MTcy427.09c hypothetical 39.2 kd protein from Mycobacterium tuberculosis (364 aa) FASTA scores: opt: 196, E(): 2.8e-06, (45.6% identity in 79 aa overlap). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. BELONGS TO THE PHOSPHOGLYCERATE MUTASE FAMILY.	Q7TYM3	No	intermediary metabolism and respiration							IPR001345,IPR013078	Q7TYM3	A0A1R3Y1I3				Rv2419c		Rv2419c			
NC_002945.3	Mycobrowser_v4	CDS	2686358	2686993	.	-	0	Mb2444c	nadD		PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NICOTINATE MONONUCLEOTIDE ADENYLYLTRANSFERASE) (NAMN ADENYLYLTRANSFERASE)	Mb2444c, nadD, len: 211 aa. Equivalent to Rv2421c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). Probable nadD,nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18),equivalent to Q9CBZ8|NADD_MYCLE|ML1454 PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from Mycobacterium leprae (214 aa), FASTA scores: opt: 1125,E(): 2.7e-66, (80.2% identity in 212 aa overlap). Also highly similar to Q9RDK7|NADD_STRCO PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from Streptomyces coelicolor (188 aa), FASTA scores: opt: 855,E(): 9.8e-49, (66.5% identity in 194 aa overlap); and similar to others e.g. P54455|NADD_BACSU from Bacillus subtilis (189 aa), FASTA scores: opt: 351, E(): 7e-16,(36.1% identity in 191 aa overlap); etc. BELONGS TO THE NADD FAMILY.	X2BKM6,Q7TYM1	No									X2BKM6,Q7TYM1	Q7TYM1									
NC_002945.3	Mycobrowser_v4	CDS	2692393	2693640	.	-	0	Mb2451c	proA		PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDEHYDE DEHYDROGENASE)	Mb2451c, proA, len: 415 aa. Equivalent to Rv2427c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Probable proA,gamma-glutamyl phosphate reductase protein (EC 1.2.1.41),equivalent to Q9CBZ7|ML1458|PROA [GAMMA]-GLUTAMYL PHOSPHATE REDUCTASE from Mycobacterium leprae (409 aa),FASTA scores: opt: 2120, E(): 7.4e-118, (81.9% identity in 409 aa overlap). Also highly similar or similar to other GAMMA-GLUTAMYL PHOSPHATE REDUCTASES PROTEINS (GPR) e.g. Q9RDK1|PROA from Streptomyces coelicolor (428 aa), FASTA scores: opt: 1073, E(): 4.6e-56, (60.4% identity in 429 aa overlap); P45638|PROA_CORGL from Corynebacterium glutamicum (432 aa), FASTA scores: opt: 993, E(): 2.4e-51,(58.5% identity in 417 aa overlap); P96489|PROA_STRTR GAMMA-GLUTAMYL PHOSPHATE REDUCTASE from Streptococcus thermophilus (416 aa), FASTA scores: opt: 863, E(): 1.1e-43, (49.15% identity in 413 aa overlap); etc. BELONGS TO THE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE FAMILY.	X2BKG4,P65789	No									X2BKG4,P65789	P65789									
NC_002945.3	Mycobrowser_v4	CDS	2707935	2708195	.	-	0	Mb2468c	rpmA		50s ribosomal protein l27 rpma	Mb2468c, rpmA, len: 86 aa. Equivalent to Rv2441c,len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Probable rpmA, 50S RIBOSOMAL PROTEINS L27, equivalent to Q9CBZ3|RL27_MYCLE from Mycobacterium leprae (88 aa), FASTA scores: opt: 504,E(): 7.6e-28, (93.2% identity in 81 aa overlap). Also highly similar to others e.g. P95757|RL27_STRGR from Streptomyces griseus (85 aa), FASTA scores: opt: 442, E(): 1.2e-23, (81.5% identity in 81 aa overlap); etc. Contains PS00831 Ribosomal protein L27 signature. BELONGS TO THE L27P FAMILY OF RIBOSOMAL PROTEINS.	X2BKU6,P66128	No									X2BKU6,P66128	P66128									
NC_002945.3	Mycobrowser_v4	CDS	2694356	2694943	.	+	0	Mb2454	ahpC		ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C)	Mb2454, ahpC, len: 195 aa. Equivalent to Rv2428,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 195 aa overlap). ahpC, alkyl hydroperoxide reductase C (EC 1.-.-.-) (see citations below), equivalent to other alkyl hydroperoxide reductases C mycobacterial proteins e.g. Q9CBF5|AHPC|ML2042 ALKYL HYDROPEROXIDE REDUCTASE from Mycobacterium leprae (195 aa) FASTA scores: opt: 1183, E(): 2.6e-72, (88.20% identity in 195 aa overlap); O87323|AHPC from Mycobacterium marinum (195 aa), FASTA scores: opt: 1215, E(): 1.9e-74, (90.8% identity in 195 aa overlap); Q57413|AHPC|AVI-3 from Mycobacterium avium (195 aa), FASTA scores: opt: 1201,E(): 1.6e-73, (90.25% identity in 195 aa overlap). Also highly similar to others from other organisms e.g. Q9FBP5|AHPC ALKYL HYDROPEROXIDE REDUCTASE from Streptomyces coelicolor (184 aa), FASTA scores: opt: 768,E(): 1.7e-44, (62.45% identity in 189 aa overlap); etc.	I3NIF4	No	virulence, detoxification, adaptation							IPR000866,IPR012336,IPR024706	I3NIF4	A0A1R3Y168				Rv2428		Rv2428			
NC_002945.3	Mycobrowser_v4	CDS	2694969	2695502	.	+	0	Mb2455	ahpD		ALKYL HYDROPEROXIDE REDUCTASE D PROTEIN AHPD (ALKYL HYDROPEROXIDASE D)	Mb2455, ahpD, len: 177 aa. Equivalent to Rv2429,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). ahpD, alkyl hydroperoxide reductase (EC 1.-.-.-), similar to other alkyl hydroperoxide reductases D proteins e.g. Q9RN73|AHPD from Streptomyces coelicolor (178 aa), FASTA scores: opt: 611, E(): 1.4e-33, (57.4% identity in 169 aa overlap); Q50441|AHPD_MYCSM AHPD PROTEIN (FRAGMENT) from Mycobacterium smegmatis (52 aa), FASTA score: opt:196.	X2BL65,P0A5N5	No	virulence, detoxification, adaptation								X2BL65,P0A5N5	P0A5N5				Rv2429		Rv2429			
NC_002945.3	Mycobrowser_v4	CDS	2695499	2696083	.	-	0	Mb2456c	PPE41		ppe family protein ppe41	Mb2456c, PPE41, len: 194 aa. Equivalent to Rv2430c,len: 194 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 194 aa overlap). Member of the Mycobacterium tuberculosis PPE family similar to others e.g. AAK46014|Rv1745|MT1745 from Mycobacterium tuberculosis (385 aa) FASTA scores: opt: 389, E(): 1.2e-17, (35.95% identity in 192 aa overlap); etc.	Q7TYL4	No								IPR000030	Q7TYL4	A0A1R3Y173									
NC_002945.3	Mycobrowser_v4	CDS	2708210	2708524	.	-	0	Mb2469c	rplU		50s ribosomal protein l21 rplu	Mb2469c, rplU, len: 104 aa. Equivalent to Rv2442c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Probable rplU, 50S RIBOSOMAL PROTEIN L21, equivalent to Q9CBZ2|RL21_MYCLE from Mycobacterium leprae (103 aa), FASTA scores: opt: 579, E(): 4.8e-31, (91.1% identity in 102 aa overlap). Also highly similar to others e.g. P95756|RL21_STRGR from Streptomyces griseus (106 aa), FASTA scores: opt: 362,E(): 5.4e-17, (56.0% identity in 100 aa overlap); etc.	X2BKR3,P66118	No									X2BKR3,P66118	P66118									
NC_002945.3	Mycobrowser_v4	CDS	2701393	2702307	.	+	0	Mb2462	rbsK		RIBOKINASE RBSK	Mb2462, rbsK, len: 304 aa. Equivalent to Rv2436,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 304 aa overlap). Probable rbsK,ribokinase (EC 2.7.1.15), similar to others e.g. Q9RZ99|DRA0055 from Deinococcus radiodurans (300 aa) FASTA scores: opt: 485, E(): 9.1e-21, (44.55% identity in 301 aa overlap); P36945|P96733|RBSK_BACSU from Bacillus subtilis (293 aa), FASTA scores: opt: 398, E(): 8.5e-16, (36.35% identity in 297 aa overlap); P05054|RBSK_ECOLI|B3752|Z5253|ECS4694 from Escherichia coli strain K12 (309 aa), FASTA scores: opt: 387, E(): 3.8e-15, (34.7% identity in 314 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. BELONGS TO THE PFKB FAMILY OF CARBOHYDRATE KINASES.	Q7TYK8	No	intermediary metabolism and respiration							IPR002139,IPR011611	Q7TYK8	A0A1R3Y1K3				Rv2436		Rv2436			
NC_002945.3	Mycobrowser_v4	CDS	2726371	2727651	.	-	0	Mb2484c	clpX		PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX	Mb2484c, clpX, len: 426 aa. Equivalent to Rv2457c,len: 426 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 426 aa overlap). Probable clpX,ATP-dependent clp protease ATP-binding subunit clpX (EC 3.4.-.-), equivalent to Q9CBY6|CLPX|ML1477 ATP-DEPENDENT CLP PROTEASE ATP-BINDING PROTEIN from Mycobacterium leprae (426 aa), FASTA scores: opt: 2652, E(): 1.4e-142, (96.0% identity in 426 aa overlap). Also highly similar to others e.g. Q9F316|CLPX from Streptomyces coelicolor (428 aa) FASTA scores: opt: 2178, E(): 8.2e-116, (77.8% identity in 428 aa overlap); P50866|CLPX_BACSU from Bacillus subtilis (420 aa), FASTA scores: opt: 1788, E(): 8.5e-94, (63.6% identity in 426 aa overlap); P33138|CLPX_ECOLI from Escherichia coli (423 aa), FASTA scores: opt: 1694, E(): 1.7e-88, (62.4% identity in 415 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CLPX CHAPERONE FAMILY.	X2BKU9,P0A529	No									X2BKU9,P0A529	P0A529									
NC_002945.3	Mycobrowser_v4	CDS	2702955	2704994	.	-	0	Mb2464c	nadE		GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING])	Mb2464c, nadE, len: 679 aa. Equivalent to Rv2438c,len: 679 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 679 aa overlap). nadE,glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (see citation below), equivalent to Q9CBZ6|NADE_MYCLE|ML1463 Glutamine-dependent NAD(+) synthetase from Mycobacterium leprae (680 aa), FASTA scores: opt: 3877, E(): 0. Also similar to others e.g. O83759|NADE_TREPA|TP0780 from Treponema pallidum (679 aa), FASTA scores: opt: 543, E(): 1.1e-25; O74940|NADE_SCHPO|SPCC553.02 from Schizosaccharomyces pombe (Fission yeast) (700 aa), FASTA scores: opt: 354, E(): 4.7e-14 ; P38795|NADE_YEAST|YHR074W from Saccharomyces cerevisiae (Baker's yeast) (714 aa),FASTA scores: opt: 339, E(): 4e-13; etc. Contains PS00591 Glycosyl hydrolases family 10 active site. BELONGS TO THE NAD SYNTHETASE FAMILY IN THE C-TERMINAL SECTION. N-terminus shorter since first submission.	X2BKQ4,P0A5L7	No									X2BKQ4,P0A5L7	P0A5L7									
NC_002945.3	Mycobrowser_v4	CDS	2705280	2706410	.	-	0	Mb2466c	proB		PROBABLE GLUTAMATE 5-KINASE PROTEIN PROB (GAMMA-GLUTAMYL KINASE) (GK)	Mb2466c, proB, len: 376 aa. Equivalent to Rv2439c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 376 aa overlap). Probable proB,glutamate 5-kinase protein (GK) (EC 2.7.2.11), equivalent to Q9CBZ5|PROB|ML1464 from Mycobacterium leprae (367 aa) FASTA scores: opt: 1937, E(): 1.1e-102, (84.4% identity in 366 aa overlap). Also highly similar to other glutamate 5-kinase proteins e.g. P46546|PROB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (369 aa), FASTA scores: opt: 1241, E(): 3e-63, (54.35% identity in 368 aa overlap); Q9ZG98|PROB_MEIRU GLUTAMATE 5-KINASE from Meiothermus ruber (390 aa), FASTA scores: opt: 825,E(): 1.2e-39, (45.05% identity in 353 aa overlap); Q9RDJ9|PROB|SCC123.25c from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1193, E(): 1.6e-60, (55.85% identity in 367 aa overlap); etc. Contains PS00902 Glutamate 5-kinase signature. BELONGS TO THE GLUTAMATE 5-KINASE FAMILY.	X2BKI0,P59958	No									X2BKI0,P59958	P59958									
NC_002945.3	Mycobrowser_v4	tRNA	2733704	2733774	.	+	0	glyV	glyV		tRNA-Gly	glyV, len: 71 nt. Equivalent to glyV, len: 71 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 nt overlap). tRNA-Gly; anticodon tcc.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2708872	2710347	.	+	0	Mb2470	dctA		PROBABLE C4-DICARBOXYLATE-TRANSPORT TRANSMEMBRANE PROTEIN DCTA	Mb2470, dctA, len: 491 aa. Equivalent to Rv2443,len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 491 aa overlap). Probable dctA,C4-dicarboxylate-transport transmembrane protein, similar to other C4-DICARBOXYLATE TRANSPORT PROTEINS e.g. AAK46817|MT2519 from Mycobacterium tuberculosis strain CDC1551 (491 aa); Q9L1K8|SC6A11.12 PUTATIVE SODIUM:DICARBOXYLATE SYMPORTER from Streptomyces coelicolor (466 aa), FASTA scores: opt: 1797, E(): 2.9e-98, (61.3% identity in 452 aa overlap); Q9RRG7|DR2525 from Deinococcus radiodurans (463 aa); P50334|DCTA_SALTY from Salmonella typhimurium (428 aa) FASTA scores: opt: 1241, E(): 1.3e-65, (47.2% identity in 415 aa overlap); etc. BELONGS TO THE SODIUM DICARBOXYLATE SYMPORTER FAMILY (SDF) (DAACS FAMILY).	Q7TYK4	No	cell wall and cell processes							IPR001991	Q7TYK4	A0A1R3Y209				Rv2443		Rv2443			
NC_002945.3	Mycobrowser_v4	CDS	2999178	2999654	.	+	0	Mb2749	Mb2749		HYPOTHETICAL PROTEIN	Mb2749, -, len: 158 aa. Equivalent to Rv2730, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Hypothetical unknown protein.	Q7TY08,A0A1R3Y275	No	conserved hypotheticals			A0A1R3Y275					Q7TY08					Rv2730		Rv2730			
NC_002945.3	Mycobrowser_v4	CDS	2731335	2731937	.	-	0	Mb2488c	clpP1		PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Mb2488c, clpP1, len: 200 aa. Equivalent to Rv2461c,len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 200 aa overlap). Probable clpP1,ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92), equivalent to Q9CBY3|CLP1_MYCLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT from Mycobacterium leprae (224 aa), FASTA scores: opt: 1226, E(): 1.3e-71, (95.0% identity in 200 aa overlap). Also highly similar to others e.g. Q9F315|CLPP1 from Streptomyces coelicolor (219 aa),FASTA scores: opt: 713, E(): 9.3e-39, (61.75% identity in 183 aa overlap); P80244|CLPP_BACSU from Bacillus subtilis (197 aa), FASTA scores: opt: 658, E(): 2.8e-35, (54% identity in 187 aa overlap); Q9WZF9|CLPP_THEMA|TM0695 from Thermotoga maritima (203 aa), FASTA scores: opt: 653, E(): 6.1e-35, (55.25% identity in 172 aa overlap); etc. Also similar to downstream ORF Rv2460c|MTV008.16c|clpP2 (214 aa), FASTA score: (48.3% identity in 172 aa overlap). BELONGS TO PEPTIDASE FAMILY S14, ALSO KNOWN AS CLPP FAMILY. Note that previously known as clp.	X2BKX6,P0A527	No									X2BKX6,P0A527	P0A527									
NC_002945.3	Mycobrowser_v4	CDS	2710286	2713147	.	-	0	Mb2471c	rne		POSSIBLE RIBONUCLEASE E RNE	Mb2471c, rne, len: 953 aa. Equivalent to Rv2444c,len: 953 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 953 aa overlap). Possible rne,ribonuclease E (EC 3.1.-.-), highly similar to others e.g. Q9CBZ1|ML1468 POSSIBLE RIBONUCLEASE from Mycobacterium leprae (924 aa), FASTA scores: opt: 3713, E(): 2.4e-174,(74.2% identity in 966 aa overlap); Q9SI08|AT2G04270 PUTATIVE RIBONUCLEASE E from Arabidopsis thaliana (502 aa), FASTA scores: opt: 674, E(): 7.5e-26, (31.2% identity in 410 aa overlap); etc. Similar at C-terminal end to P21513|RNE_ECOLI|AMS|HMP1|B1084 ribonuclease E (EC 3.1.4.-) (RNASE E) from Escherichia coli strain K12 (1061 aa), FASTA scores: opt: 554, E(): 9.9e-20, (37.8% identity in 386 aa overlap). Also similar in medium part to several cytoplasmic axial filament proteins e.g. Q9HVU4|CAFA|PA4477 from Pseudomonas aeruginosa (485 aa),FASTA scores: opt: 664, E(): 2.3e-25, (42.8% identity in 418 aa overlap); etc. Equivalent to AAK46818 from Mycobacterium tuberculosis strain CDC1551 (621 aa) but longer 332 aa in N-terminal part. SEEMS TO BELONG TO THE RNE FAMILY.	Q7TYK3	No								IPR003029,IPR004659,IPR012340,IPR019307,IPR022967	Q7TYK3	A0A1R3Y1F2									
NC_002945.3	Mycobrowser_v4	CDS	2761152	2761922	.	+	0	Mb2511	echA14		PROBABLE ENOYL-COA HYDRATASE ECHA14 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb2511, echA14, len: 256 aa. Equivalent to Rv2486,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable echA14,enoyl-coA hydratase (EC 4.2.1.17), similar to others e.g. P24162|ECHH_RHOCA2|FADB1 from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores; opt: 453, E(): 3.8e-23, (39.4% identity in 259 aa overlap); Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa), FASTA scores: opt: 404, E(): 5.7e-17, (37.5% identity in 224 aa overlap); P77467|PAAG_ECOLI from Escherichia coli (262 aa), FASTA scores: opt: 401, E(): 8.3e-17, (36.3% identity in 259 aa overlap); etc. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY.	X2BL76,P64019	No									X2BL76,P64019	P64019									
NC_002945.3	Mycobrowser_v4	CDS	2713477	2713887	.	-	0	Mb2472c	ndkA		PROBABLE NUCLEOSIDE DIPHOSPHATE KINASE NDKA (NDK) (NDP KINASE) (NUCLEOSIDE-2-P KINASE)	Mb2472c, ndkA, len: 136 aa. Equivalent to Rv2445c,len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Probable ndkA (alternate gene name: ndk), nucleoside diphosphate kinase (EC 2.7.4.6), equivalent to Q9CBZ0|NDK|ML1469 from Mycobacterium leprae (136 aa), FASTA scores: opt: 762,E(): 1.5e-42, (87.4% identity in 135 aa overlap); and O85501|NDK from Mycobacterium smegmatis (139 aa), FASTA scores: opt: 714, E(): 1.9e-39, (80.7% identity in 135 aa overlap). Also highly similar to others e.g. P50589|NDK_STRCO from Streptomyces coelicolor (137 aa),FASTA scores: opt: 535, 6.8e-28, (60.3% identity in 136 aa overlap); O29491|NDK_ARCFU|AF0767 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 521, E(): 5.9e-27,(58.0% identity in 131 aa overlap); P31103|NDK_BACSU from Bacillus subtilis (151 aa), FASTA scores: opt: 515, E(): 1.4e-26, (56.5% identity in 131 aa overlap); etc. BELONGS TO THE NDK FAMILY.	X2BL38,P84283	No									X2BL38,P84283	P84283									
NC_002945.3	Mycobrowser_v4	tRNA	2937404	2937475	.	+	0	valU	valU		tRNA-Val	valU, len: 72 nt. Equivalent to valU, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Val, anticodon gac.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3085535	3085909	.	-	0	Mb2846c	Mb2846c		HYPOTHETICAL PROTEIN	Mb2846c, -, len: 124 aa. Equivalent to Rv2822c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Hypothetical unknown protein.	Q7TXS5,A0A1R3Y492	No	conserved hypotheticals			A0A1R3Y492				IPR010149	Q7TXS5					Rv2822c		Rv2822c			
NC_002945.3	Mycobrowser_v4	CDS	2714298	2715761	.	-	0	Mb2474c	folC		PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS)	Mb2474c, folC, len: 487 aa. Equivalent to Rv2447c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 487 aa overlap). Probable folC,folylpolyglutamate synthase (EC 6.3.2.17), equivalent to Q9CBY8|FOLC|ML1471 from Mycobacterium leprae (485 aa),FASTA scores: opt: 2425, E(): 2.2e-134, (78.7% identity in 483 aa overlap). Also highly similar to others e.g. Q9L1G4|FPGS|O08416|Y13070 from Streptomyces coelicolor (444 aa), FASTA scores: opt: 774, E(): 6.3e-38, (53.9% identity in 462 aa overlap); P15925|FOLC_LACCA|FGS from Lactobacillus casei (428 aa), FASTA scores: opt: 631, E(): 1.4e-29, (34.55% identity in 437 aa overlap); Q05865|FOLC_BACSU from Bacillus subtilis (430 aa), FASTA scores: opt: 421, E(): 2.6e-17, (32.9% identity in 383 aa overlap); etc. Contains PS01012 Folylpolyglutamate synthase signature 2. BELONGS TO THE FOLYLPOLYGLUTAMATE SYNTHASE FAMILY.	Q7TYK1	No								IPR001645,IPR004101,IPR013221,IPR018109	Q7TYK1	A0A1R3Y188									
NC_002945.3	Mycobrowser_v4	CDS	2715758	2718388	.	-	0	Mb2475c	valS		PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE)	Mb2475c, valS, len: 876 aa. Equivalent to Rv2448c,len: 876 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 876 aa overlap). Probable valS,valyl-tRNA synthetases (EC 6.1.1.9), equivalent to Q9CBY7|VALS|ML1472 VALYL-TRNA SYNTHASE from Mycobacterium leprae (886 aa), FASTA scores: opt: 5181,E(): 0, (85.4% identity in 876 aa overlap). Also highly similar to others e.g. O06851|SYV_STRCO from Streptomyces coelicolor (874 aa), FASTA scores: opt: 2470, E(): 1.6e-143, (60.45% identity in 880 aa overlap); Q9X2D7|SYV_THEMA|VALS|TM1817 from Thermotoga maritima (865 aa), FASTA scores: opt: 2418, E(): 2.4e-140, (44.2% identity in 891 aa overlap); Q05873|SYV_BACSU|VALS from Bacillus subtilis (880 aa),FASTA scores: opt: 2063, E(): 1.4e-118, (46.08% identity in 894 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Contains probable coiled-coil from aa 810 to 846. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BLE0,P67600	No									X2BLE0,P67600	P67600									
NC_002945.3	Mycobrowser_v4	CDS	2719825	2720343	.	-	0	Mb2477c	rpfE		PROBABLE RESUSCITATION-PROMOTING FACTOR RPFE	Mb2477c, rpfE, len: 172 aa. Equivalent to Rv2450c,len: 172 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 172 aa overlap). Probable rpfE,resuscitation-promoting factor (see first citation below),similar to O86308|Z96935|MLRPF_1 RPF PROTEIN PRECURSOR from Micrococcus luteus (220 aa), FASTA scores: opt: 291,E(): 3e-7, (48.75% identity in 80 aa overlap). C-terminus is similar to other Mycobacterial rpf proteins e.g. O05594|Rv1009|MTCI237.26|RPFB PROBABLE RESUSCITATION-PROMOTING FACTOR from Mycobacterium tuberculosis (362 aa), FASTA scores: opt: 344, E(): 1.4e-09, (42.85% identity in 147 aa overlap); etc. C-terminal region similar to N-terminal region of Q9F2Q2|SCE41.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 355,E(): 3.1e-10, (56.65% identity in 90 aa overlap). Also similar to Q9F2Q1|SCE41.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (near Q9F2Q2|SCE41.06c) (341 aa) FASTA scores: opt: 317, E(): 2.5e-08, (51.7% identity in 87 aa overlap). With Mycobacterium leprae, high similarity between the two corresponding C-terminal regions of two HYPOTHETICAL PROTEINS, Q9CD53|ML0240 (375 aa), FASTA scores: opt: 339, E(): 2.5e-09, (59.15% identity in 93 aa overlap) and O33049|MLCB57.05c|ML2151 (174 aa), FASTA scores: opt: 329, E(): 4e-09, (58.14% identity in 86 aa overlap). Contains a possible secretory signal sequence in N-terminus. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citation below).	Q7TYJ9	No								IPR010618,IPR023346	Q7TYJ9	A0A1R3Y199									
NC_002945.3	Mycobrowser_v4	CDS	3433608	3434048	.	+	0	Mb3135	Mb3135		HYPOTHETICAL PROTEIN	Mb3135, -, len: 146 aa. Equivalent to Rv3108, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 146 aa overlap). Hypothetical unknown protein.	Q7TX85,A0A1R3Y351	No	conserved hypotheticals			A0A1R3Y351					Q7TX85					Rv3108		Rv3108			
NC_002945.3	Mycobrowser_v4	CDS	2721181	2721786	.	-	0	Mb2480c	mobA		PROBABLE MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A MOBA	Mb2480c, mobA, len: 201 aa. Equivalent to Rv2453c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable mobA,molybdopterin-guanine dinucleotide biosynthesis protein A,similar to others e.g. Q9F8G7 from Carboxydothermus hydrogenoformans (224 aa), FASTA scores: opt: 249, E(): 3.9e-08, (30.6% identity in 173 aa overlap); P95645|MOBA_RHOSH|MOB|Y09560 from Rhodobacter sphaeroides (199 aa), FASTA scores: opt: 240, E(): 1.2e-07, (33.9% identity in 186 aa overlap); Q9X7K0|MOBA_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (191 aa), FASTA scores: opt: 217, E(): 2.9e-06, (37.4% identity in 123 aa overlap); etc. BELONGS TO THE MOBA FAMILY.	X2BLF3,P65403	No									X2BLF3,P65403	P65403									
NC_002945.3	Mycobrowser_v4	CDS	2727942	2728850	.	+	0	Mb2485	mmuM		PROBABLE HOMOCYSTEINE S-METHYLTRANSFERASE MMUM (S-METHYLMETHIONINE:HOMOCYSTEINE METHYLTRANSFERASE) (CYSTEINE METHYLTRANSFERASE)	Mb2485, mmuM, len: 302 aa. Equivalent to Rv2458,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Probable mmuM,homocysteine S-methyltransferase (EC 2.1.1.10), equivalent to Q9CBY5|ML1478 POSSIBLE TRANSFERASE from Mycobacterium leprae (293 aa), FASTA scores: opt: 1507, E(): 2.7e-86,(78.85% identity in 293 aa overlap). Also similar to others e.g. Q47690|MMUM_ECOLI|B0261 HOMOCYSTEINE S-METHYLTRANSFERASE from Escherichia coli strain K12 (310 aa), FASTA scores: opt: 863, E(): 2.4e-46, (47.65% identity in 298 aa overlap); Q9FUM7 HOMOCYSTEINE S-METHYLTRANSFERASE-4 from Zea mays (Maize) (342 aa),FASTA scores: opt: 324, E(): 6.8e-13, (44.45% identity in 306 aa overlap); Q9LUI7|HMT3 CYSTEINE METHYLTRANSFERASE from Arabidopsis thaliana (Mouse-ear cress) (347 aa),FASTA scores: opt: 312, E(): 3.8e-12, (41.85% identity in 313 aa overlap); etc. Identical to AAK46833|MT2533 HOMOCYSTEINE S-METHYLTRANSFERASE from Mycobacterium tuberculosis strain CDC1551 (302 aa).	Q7TYJ3	No	intermediary metabolism and respiration							IPR003726	Q7TYJ3	A0A1R3Y1A0				Rv2458		Rv2458			
NC_002945.3	Mycobrowser_v4	CDS	2730694	2731338	.	-	0	Mb2487c	clpP2		PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Mb2487c, clpP2, len: 214 aa. Equivalent to Rv2460c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable clpP2,ATP-dependent clp protease proteolytic subunit 2 (EC 3.4.21.92), equivalent to Q9CBY4|CLP2_MYCLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT from Mycobacterium leprae (214 aa). Also highly similar to others e.g. Q9ZH58|CLPP2 from Streptomyces coelicolor (236 aa), FASTA scores: opt: 918, E(): 2.1e-50, (66.35% identity in 214 aa overlap); O67357|CLPP_AQUAE|AQ_1339 from Aquifex aeolicus (201 aa),FASTA scores: opt: 680, E(): 1.4e-35, (52.0% identity in 194 aa overlap); P43867|CLPP_HAEIN from Haemophilus influenzae (193 aa), FASTA scores: opt: 662, E(): 1.8e-34,(53.35% identity in 193 aa overlap); etc. Contains PS00381 Endopeptidase Clp serine active site. Also similar to upstream ORF Rv2461c|MTV008.17c|clpP1 (200 aa), FASTA score: (48.3% identity in 172 aa overlap). BELONGS TO PEPTIDASE FAMILY S14, ALSO KNOWN AS CLPP FAMILY.	X2BL63,P63784	No									X2BL63,P63784	P63784									
NC_002945.3	Mycobrowser_v4	CDS	2737149	2739734	.	+	0	Mb2494	pepN		PROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE)	Mb2494, pepN, len: 861 aa. Equivalent to Rv2467,len: 861 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 861 aa overlap). Probable pepN,aminopeptidase N (EC 3.4.11.2), equivalent to Q9CBX9|ML1486 PROBABLE AMINOPEPTIDASE from Mycobacterium leprae (862 aa), FASTA scores: opt: 4751,E(): 0, (83.3% identity in 862 aa overlap). Also highly similar to others e.g. Q11010|AMPN_STRLI|PEPN from Streptomyces lividans (857 aa), FASTA scores: opt: 2839, E(): 1.8e-170, (53.25% identity in 864 aa overlap); Q9L1Z2|PEPN from Streptomyces coelicolor (857 aa), FASTA scores: opt: 2834, E(): 3.8e-170, (53.1% identity in 864 aa overlap); P37896|AMPN_LACDL|PEPN from Lactobacillus delbrueckii (subsp. lactis) (842 aa), FASTA scores: opt: 719, E(): 2.4e-37, (31.65% identity in 439 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M1 (ZINC METALLOPROTEASE), ALSO KNOWN AS THE PEPN SUBFAMILY. Note that previously known as pepD.	Q7TYI7	No	intermediary metabolism and respiration							IPR001930,IPR012778,IPR014782,IPR024571	Q7TYI7	A0A1R3Y1B2				Rv2467		Rv2467			
NC_002945.3	Mycobrowser_v4	CDS	2732054	2733454	.	-	0	Mb2489c	tig		PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	Mb2489c, tig, len: 466 aa. Equivalent to Rv2462c,len: 466 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 466 aa overlap). Probable tig, trigger factor (TF), a chaperone protein, equivalent to Q9CBY2|ML1481 POSSIBLE MOLECULAR CHAPERONE from Mycobacterium leprae (469 aa), FASTA scores: opt: 2171,E(): 7.2e-113, (70.1% identity in 468 aa overlap). Also similar to oyher trigger factors from several organisms e.g. Q9F314|SCC80.05c from Streptomyces coelicolor (468 aa), FASTA scores: opt: 1224, E(): 1.7e-60, (41.8% identity in 469 aa overlap); Q9K8F3|TIG_BACHD from Bacillus halodurans (431 aa), FASTA scores: opt: 675, E(): 3.6e-30, (28.5% identity in 421 aa overlap); P22257|TIG_ECOLI from Escherichia coli (432 aa), FASTA scores: opt: 493, E(): 4.2e-20, (23.35% identity in 433 aa overlap); etc. BELONGS TO THE FKBP-TYPE PPIASE FAMILY, TIG SUBFAMILY.	X2BKV3,Q7TYJ1	No									X2BKV3,Q7TYJ1	Q7TYJ1									
NC_002945.3	Mycobrowser_v4	CDS	2733818	2735002	.	+	0	Mb2490	lipP		PROBABLE ESTERASE/LIPASE LIPP	Mb2490, lipP, len: 394 aa. Equivalent to Rv2463,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 394 aa overlap). Probable lipP,esterase (EC 3.1.-.-), lipase similar to others eg O87861|ESTA ESTERASE A from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 964, E(): 1.9e-53, (44.35% identity in 399 aa overlap); Q9I4S7|PA1047 PROBABLE ESTERASE from Pseudomonas aeruginosa (392 aa), FASTA scores: opt: 863, E(): 4.6e-47, (40.05% identity in 377 aa overlap); Q53403|ESTC ESTERASE III from Pseudomonas fluorescens (382 aa), FASTA scores: opt: 753, E(): 3.9e-40, (36.3% identity in 380 aa overlap); etc.	Q7TYJ0	No	intermediary metabolism and respiration							IPR001466,IPR012338	Q7TYJ0	A0A1R3Y234				Rv2463		Rv2463			
NC_002945.3	Mycobrowser_v4	CDS	2735834	2736322	.	-	0	Mb2492c	rpib		ribose-5-phosphate isomerase	Mb2492c, -, len: 162 aa. Equivalent to Rv2465c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Probable isomerase (EC 5.-.-.-), equivalent to AAK46840|MT2540 PUTATIVE CARBOHYDRATE-PHOSPHATE ISOMERASE from Mycobacterium tuberculosis strain CDC1551 (159 aa). Equivalent to Q9CBY1|ML1484 POSSIBLE PHOSPHOPENTOSE ISOMERASE from M. leprae (162 aa), FASTA scores: opt: 992, E(): 7.1e-59,(89.5% identity in 162 aa overlap). Also highly similar or similar to several diverse isomerases e.g. Q9L206|SC8E4.02c PUTATIVE ISOMERASE from Streptomyces coelicolor (159 aa), FASTA scores: opt: 661, E(): 6.1e-37,(61.45% identity in 153 aa overlap); P47636|Y396_MYCGE|MG396 HYPOTHETICAL LACA/RPIB FAMILY PROTEIN from Mycoplasma genitalium (152 aa), FASTA scores: opt: 357, E(): 8.2e-17, (42% identity in 150 aa overlap); P53527|Y396_MYCPN|MPN595|MP247 HYPOTHETICAL LACA/RPIB FAMILY PROTEIN from Mycoplasma pneumoniae (152 aa), FASTA scores: opt: 340, E(): 1.1e-15, (38.6% identity in 145 aa overlap); P26592|LACB_STAAU galactose-6-phosphate isomerase from Staphylococcus aureus (171 aa), FASTA scores: opt: 296, E(): 1e-12, (35.4% identity in 158 aa overlap) and P37351|RPIB_ECOLI ribose 5-phosphate isomerase b from Escherichia coli (149 aa), FASTA scores: opt: 262, E(): 1.6e-10, (32.2% identity in 146 aa overlap); etc. COULD BELONG TO THE LACA/RPIB FAMILY.	X2BL66,Q7TYI9	No	intermediary metabolism and respiration								X2BL66,Q7TYI9	Q7TYI9				Rv2465c		Rv2465c			
NC_002945.3	Mycobrowser_v4	CDS	2741341	2741727	.	+	0	Mb2497	glbO		globin (oxygen-binding protein) glbo	Mb2497, glbO, len: 128 aa. Equivalent to Rv2470,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Possible glbO,globin-like protein, highly similar to Q9CC59|GLBO|ML1253 HEMOGLOBIN-LIKE (OXYGEN CARRIER) from Mycobacterium leprae (128 aa), FASTA scores: opt: 767, E(): 4e-47, (88.1% identity in 126 aa overlap); Q9X7B3|MLCB1610.14c PUTATIVE GLOBIN from Mycobacterium leprae (131 aa); Q9L250|SC6D10.14 PUTATIVE GLOBIN from Streptomyces coelicolor (137 aa), FASTA scores: opt: 466, E(): 5.7e-26,(53.6% identity in 125 aa overlap). Also similar to O31607 YJBI PROTEIN from Bacillus subtilis (132 aa), FASTA scores: opt: 294, E(): 6.6e-14; (39.85% identity in 128 aa overlap). COULD BELONG TO PROTOZOAN/CYANOBACTERIAL GLOBIN FAMILY PROTEIN.	X2BKY2,P0A596	No	intermediary metabolism and respiration								X2BKY2,P0A596	P0A596				Rv2470		Rv2470			
NC_002945.3	Mycobrowser_v4	CDS	2741727	2743367	.	+	0	Mb2498	aglA		PROBABLE ALPHA-GLUCOSIDASE AGLA (MALTASE) (GLUCOINVERTASE) (GLUCOSIDOSUCRASE) (MALTASE-GLUCOAMYLASE) (LYSOSOMAL ALPHA-GLUCOSIDASE) (ACID MALTASE)	Mb2498, aglA, len: 546 aa. Equivalent to Rv2471,len: 546 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 546 aa overlap). Probable aglA, maltase (alpha-glucosidase) (EC 3.2.1.20), highly similar or similar to several e.g. Q60027|AGLA from Thermomonospora curvata (544 aa), FASTA scores: opt: 2071, E(): 4e-116,(57.7% identity in 525 aa overlap); Q9KZE3|AGLAE from Streptomyces coelicolor (534 aa), FASTA scores: opt: 1475,E(): 1.5e-80, (50.1% identity in 537 aa overlap); O86874|AGLA from Streptomyces lividans (534 aa), FASTA scores: opt: 1473, E(): 2e-80, (50.1% identity in 537 aa overlap); etc. SEEMS TO BELONG TO FAMILY 13 OF GLYCOSYL HYDROLASES, ALSO KNOWN AS THE ALPHA-AMYLASE FAMILY.	Q7TYI4	No	intermediary metabolism and respiration							IPR006047,IPR006589,IPR013781,IPR015902,IPR017853	Q7TYI4	A0A1R3Y3F9				Rv2471		Rv2471			
NC_002945.3	Mycobrowser_v4	CDS	2836059	2836316	.	+	0	Mb2577	vapb19		possible antitoxin vapb19	Mb2577, -, len: 85 aa. Equivalent to Rv2547, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein. Some similarity to P71666|YD98_MYCTU|Rv1398c|MT1442|MTCY21B4.15c HYPOTHETICAL 9.4 KDA PROTEIN from Mycobacterium tuberculosis (85 aa),FASTA scores: opt: 108, E(): 0.33, (37.1% identity in 62 aa overlap); CAC45864|SMC01933 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (71 aa), FASTA scores: opt: 105, E(): 0.46, (28.4% identity in 74 aa overlap); Q97W38|SSO10342 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (58 aa), FASTA scores: opt: 94, E(): 2.3, (46.95% identity in 49 aa overlap).	Q7TYB8	No	virulence, detoxification, adaptation							IPR002145,IPR010985	Q7TYB8	A0A1R3Y1I0				Rv2547		Rv2547			
NC_002945.3	Mycobrowser_v4	CDS	2745551	2750422	.	-	0	Mb2503c	gdh		PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE)	Mb2503c, gdh, len: 1623 aa. Equivalent to Rv2476c,len: 1624 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1624 aa overlap). Probable gdh,glutamate dehydrogenase (EC 1.4.1.2). Highly similar to Q9X7B2|MLCB1610.10|ML1249 HYPOTHETICAL 177.9 KDA PROTEIN from Mycobacterium leprae (1622 aa), FASTA scores: opt: 8630,E(): 0, (81.45% identity in 1634 aa overlap). But highly similar to Q9F0J1|GDH NAD-GLUTAMATE DEHYDROGENASE from Streptomyces clavuligerus (1651 aa), FASTA scores: opt: 3833, E(): 0, (45.8% identity in 1600 aa overlap); (see first citation). Also similar with others e.g. AAG53963|PA3068|GDHB HYPOTHETICAL (NAD(+)-DEPENDENT GLUTAMATE DEHYDROGENASE from Pseudomonas aeruginosa (1620 aa), FASTA scores: opt: 2214, E(): 1e-124, (40.1% identity in 1561 aa overlap) (see second citation); and Q9Y8G5|GDHB NAD-SPECIFIC GLUTAMATE DEHYDROGENASE from Agaricus bisporus (1029 aa), FASTA scores: opt: 194, E(): 0.00099,(22.7% identity in 647 aa overlap) (see third citation); etc. Contains possible Helix-turn-helix motif at aa 1568 to 1589 (score 1098, +2.93 SD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa).	Q7TYH9	No								IPR007780,IPR016040	Q7TYH9	A0A1R3Y1C3									
NC_002945.3	Mycobrowser_v4	CDS	2775555	2776736	.	-	0	Mb2523c	bkdc		probable branched-chain keto acid dehydrogenase e2 component bkdc	Mb2523c, pdhC, len: 393 aa. Equivalent to Rv2495c,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 393 aa overlap). Probable pdhC,dihydrolipoamide S-acetyltransferase, e2 component (EC 2.3.1.12), similar to others e.g. Q9XA49|SCGD3.30c from Streptomyces coelicolor (491 aa) FASTA scores: opt: 615,E(): 1.2e-28, (36.45% identity in 491 aa overlap; several gaps); P19262|ODO2_YEAST|KGD2|YDR148C|YD8358.05c from Saccharomyces cerevisiae (Baker's yeast) (463 aa) FASTA scores: opt: 533, E(): 7.1e-24, (28.55% identity in 396 aa overlap); Q9HN75|DSA|VNG2219G from Halobacterium sp. strain NRC-1 (478 aa), FASTA scores: opt: 521, E(): E(): 3.7e-23, (30.25% identity in 486 aa overlap; in part); etc. BELONGS TO THE 2-OXOACID DEHYDROGENASE FAMILY.	Q7TYG2	No								IPR000089,IPR001078,IPR004167,IPR011053,IPR023213	Q7TYG2	A0A1R3Y1B8									
NC_002945.3	Mycobrowser_v4	CDS	2753716	2756085	.	-	0	Mb2507c	plsB2		PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE PLSB2 (GPAT)	Mb2507c, plsB2, len: 789 aa. Equivalent to Rv2482c,len: 789 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 789 aa overlap). Probable plsB2,glycerol-3-phosphate acyltransferase (EC 2.3.1.15), highly similar to Q9X7B0|PLSB_MYCLE PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE from Mycobacterium leprae (775 aa), FASTA scores: opt: 4210, E(): 0, (80.7% identity in 783 aa overlap). Also similar to others e.g. P00482|PLSB_ECOLI from Escherichia coli (806 aa), FASTA scores: opt: 521,E(): 3e-24, (24.35 identity in 612 aa overlap); Q9CLN7|PLSB_PASMU from Pasteurella multocida (809 aa),FASTA scores: opt: 529, E(): 9.7e-25, (27.05% identity in 540 aa overlap); Q9KVP8|PLSB_VIBCH from Vibrio cholerae (811 aa), FASTA scores: opt: 510, E(): 1.4e-23, (26.0% identity in 639 aa overlap); etc. Also highly similar to Q10775|PLSB1|Rv1551|MTCY48.14c from Mycobacterium tuberculosis (621 aa), FASTA scores: opt: 1013, E(): 1.5e-54, (34.65% identity in 586 aa overlap). BELONGS TO THE GPAT/DAPAT FAMILY.	X2BKY7,Q7TYH5	No									X2BKY7,Q7TYH5	Q7TYH5									
NC_002945.3	Mycobrowser_v4	CDS	2756082	2757824	.	-	0	Mb2508c	plsC		possible transmembrane phospholipid biosynthesis bifunctional enzyme plsc: putative l-3-phosphoserine phosphatase (o-phosphoserine phosphohydrolase) (psp) (pspase) + 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-agp acyltransferase) (1-agpat) (lysophosphatidic acid acyltransferase) (lpaat)	Mb2508c, plsC, len: 580 aa. Equivalent to Rv2483c,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 580 aa overlap). Possible plsC, a transmembrane phospholipid biosynthesis bifunctionnal enzyme, including L-3-phosphoserine phosphatase (EC 3.1.3.3) and 1-acyl-Sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51), equivalent to Q9X7A9|PLSC|ML1245 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (579 aa), FASTA scores: opt: 2835,E(): 9.2e-153, (77.15% identity in 573 aa overlap). C-terminal end is similar to many 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASES (LYSOPHOSPHATIDIC ACIDACYLTRANSFERASES) e.g. Q9SDQ2 from Limnanthes floccosa (281 aa), FASTA scores: opt: 378, E(): 3.1e-14, (30.0% identity in 230 aa overlap) and Q42868|PLSC_LIMAL from Limnanthes alba (White meadowfoam) (281 aa), FASTA scores: opt: 374, E(): 5.2e-14, (30.55% identity in 221 aa overlap); and the N-terminal end is similar to many SERB FAMILY PROTEINS e.g. AAK44749|MT0526 from Mycobacterium tuberculosis strain CDC1551 (308 aa),FASTA scores: opt: 356, E(): 5.8e-13, (32.5% identity in 298 aa overlap) and Q49823|ML2424 from Mycobacterium leprae (300 aa), FASTA scores: opt: 346, E(): 2.1e-12,(32.0% identity in 278 aa overlap). So belongs to the 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE FAMILY and may belong to the SERB FAMILY.	Q7TYH4	No								IPR002123,IPR006383,IPR006385,IPR023214	Q7TYH4	A0A1R3Y3G3									
NC_002945.3	Mycobrowser_v4	CDS	2759525	2760790	.	-	0	Mb2510c	lipQ		PROBABLE CARBOXYLESTERASE LIPQ	Mb2510c, lipQ, len: 421 aa. Equivalent to Rv2485c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 421 aa overlap). Probable lipQ,carboxylesterase protein (lipase) (EC 3.1.-.-). Similar (greater at the C-terminal end) to AAK46626|MT2342 PUTATIVE CARBOXYLESTERASE from Mycobacterium tuberculosis strain CDC1551 (431 aa), FASTA scores: opt: 1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap); and Q50681|Rv2284|MTCY339.26c HYPOTHETICAL PROTEIN from M. tuberculosis strain H37Rv (431 aa), FASTA scores: opt: 1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap). Also similar in part to other putative lipases/esterases e.g. AAK44451|MT0230 from Mycobacterium tuberculosis strain CDC1551 (403 aa), FASTA scores: opt: 763, E(): 4.6e-38, (37.95% identity in 390 aa overlap); Q9RY19|DR0133 from Deinococcus radiodurans (296 aa), FASTA scores: opt: 392, E(): 4e-16, (33.7% identity in 276 aa overlap); Q9Z545|SC9B2.14 from Streptomyces coelicolor (502 aa) FASTA scores: opt: 279, E(): 3.2e-09, (31.15% identity in 292 aa overlap); etc.	Q7TYH2	No								IPR013094	Q7TYH2	A0A1R3Y1K5									
NC_002945.3	Mycobrowser_v4	tRNA	2760978	2761051	.	+	0	argW	argW		tRNA-Arg	argW, len: 74 nt. Equivalent to argW, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Arg; anticodon tct.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2762102	2762926	.	-	0	Mb2512c	PE_PGRS42d		PE-PGRS FAMILY PROTEIN [THIRD PART]	Mb2512c, PE_PGRS42d, len: 274 aa. Similar to 3' end of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 274 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts,PE_PGRS42a and PE_PGRS42b and PE_PGRS42d.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2762605	2763777	.	-	0	Mb2513c	PE_PGRS42b		PE-PGRS FAMILY PROTEIN [SECOND PART]	Mb2513c, PE_PGRS42b, len: 284 aa. Similar to middle section of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 284 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts,the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2763566	2764186	.	-	0	Mb2514c	PE_PGRS42a		PE-PGRS FAMILY PROTEIN [FIRST PART]	Mb2514c, PE_PGRS42a, len: 206 aa. Similar to 5' end of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 136 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from M. tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts,PE_PGRS42a and PE_PGRS42b and PE_PGRS42d.	Q7TYH1	No								IPR000084	Q7TYH1	A0A1R3Y1D3									
NC_002945.3	Mycobrowser_v4	CDS	2768055	2771507	.	-	0	Mb2517c	PE_PGRS43b		PE-PGRS FAMILY PROTEIN [SECOND PART]	Mb2517c, PE_PGRS43b, len: 1150 aa. Similar to 3' end of Rv2490c, len: 1660 aa, from Mycobacterium tuberculosis strain H37Rv, (98.0% identity in 1150 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS-subfamily of Gly-rich proteins, similar to many e.g. AAK47971|MT3612.1 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (1715 aa), FASTA scores: opt: 5161, E(): 1.5e-187, (51.7% identity in 1752 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b.	Q7TYG8	No									Q7TYG8	A0A1R3Y1D6									
NC_002945.3	Mycobrowser_v4	CDS	2771504	2773033	.	-	0	Mb2518c	PE_PGRS43a		PE-PGRS FAMILY PROTEIN [FIRST PART]	Mb2518c, PE_PGRS43a, len: 509 aa. Similar to 5' end of Rv2490c, len: 1660 aa, from Mycobacterium tuberculosis strain H37Rv, (98.0% identity in 444 aa overlap). Member of the Mycobacterium tuberculosis PE family,PGRS-subfamily of Gly-rich proteins, similar to many e.g. AAK47971|MT3612.1 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (1715 aa), FASTA scores: opt: 5161, E(): 1.5e-187, (51.7% identity in 1752 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b.	Q7TYG7	No								IPR000084	Q7TYG7	A0A1R3Y1B4									
NC_002945.3	Mycobrowser_v4	CDS	2774880	2775101	.	+	0	Mb2521	vapb38		possible antitoxin vapb38	Mb2521, -, len: 73 aa. Equivalent to Rv2493, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical protein, highly similar to AAK46916|MT2606 HYPOTHETICAL 8.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (74 aa), FASTA scores: opt: 234, E(): 4e-09,(56.95% identity in 74 aa overlap); and similar to O53373|Rv3321c|MTV016.21c HYPOTHETICAL 8.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (80 aa),FASTA scores: opt: 126, E(): 0.055, (30.75% identity in 78 aa overlap); and with weak similarity with other Mycobacterial hypothetical proteins e.g. Q9CCR7|ML0525 from Mycobacterium leprae (58 aa), FASTA scores: opt: 115,E(): 0.22, (47.75% identity in 44 aa overlap); etc.	Q7TYG4	No	virulence, detoxification, adaptation								Q7TYG4	A0A1R3Y1L5				Rv2493		Rv2493			
NC_002945.3	Mycobrowser_v4	CDS	2776733	2777779	.	-	0	Mb2524c	bkdb		probable branched-chain keto acid dehydrogenase e1 component, beta subunit bkdb	Mb2524c, pdhB, len: 348 aa. Equivalent to Rv2496c,len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 348 aa overlap). Probable pdhB,pyruvate dehydrogenase e1 component, beta subunit (EC 1.2.4.1), similar to others e.g. Q9Y8I6||PDHB from Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA scores: opt: 1050, E(): 6.4e-60, (49.7% identity in 324 aa overlap); Q9KG98|BH0214 from Bacillus halodurans (328 aa),FASTA scores: opt: 987, E(): 6.9e-56, (45.7% identity in 324 aa overlap); Q9HN76|PDHB|VNG2218G from Halobacterium sp. strain NRC-1 (297 aa), FASTA scores: opt: 968, E(): 1.1e-54, (51.2% identity in 297 aa overlap); P21874|ODPB_BACST|PDHB PYRUVATE DEHYDROGENASE E1 COMPONENT from Bacillus stearothermophilus (324 aa), FASTA scores: opt: 951, E(): 1.4e-53, (47.6% identity in 321 aa overlap); etc. Also similar to Q9XA61|SCGD3.17c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1, BETA SUBUNIT (2-oxoisovalerate dehydrogenase) (EC 1.2.4.4) from Streptomyces coelicolor, (326 aa), FASTA scores: opt: 1178, E(): 4.1e-68, (55.0% identity in 322 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT from Streptomyces coelicolor (334 aa), FASTA scores: opt: 1173, E(): 8.8e-68, (55.6% identity in 320 aa overlap); Q53593|BKDB E1-BETA BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE from Streptomyces avermitilis (334 aa), FASTA scores: opt: 1132, E(): 3.7e-65, (55.0% identity in 320 aa overlap); etc.	Q7TYG1	No								IPR005475,IPR005476,IPR009014	Q7TYG1	A0A1R3Y1E4									
NC_002945.3	Mycobrowser_v4	CDS	2767647	2767946	.	-	0	Mb2516c	Mb2516c		HYPOTHETICAL ALANINE RICH PROTEIN	Mb2516c, -, len: 99 aa. Equivalent to Rv2489c, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Hypothetical unknown ala-rich protein.	Q7TYG9	No	conserved hypotheticals								Q7TYG9	A0A1R3Y1D1				Rv2489c		Rv2489c			
NC_002945.3	Mycobrowser_v4	CDS	2818112	2818513	.	+	0	Mb2556	vapc17		possible toxin vapc17	Mb2556, -, len: 133 aa. Equivalent to Rv2527, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Hypothetical protein,showing some similarity to hypothetical proteins from Mycobacterium tuberculosis e.g. P95007|MTCY159.10c|Rv2546 (137 aa), FASTA scores: opt: 206, E(): 1.4e-07, (38.0% identity in 100 aa overlap); O33299|MTV002.22c|Rv2757c (138 aa), FASTA scores: opt: 201, E(): 3.1e-07, (35.7% identity in 126 aa overlap); and P96411|MTCY08D5.24c|Rv0229c (226 aa), FASTA scores: opt: 153, E(): 0.0011, (32.8% identity in 128 aa overlap).	Q7TYD5	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TYD5	A0A1R3Y1G9				Rv2527		Rv2527			
NC_002945.3	Mycobrowser_v4	CDS	2777790	2778893	.	-	0	Mb2525c	bkda		probable branched-chain keto acid dehydrogenase e1 component, alpha subunit bkda	Mb2525c, pdhA, len: 367 aa. Equivalent to Rv2497c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 367 aa overlap). Probable pdhA,pyruvate dehydrogenase e1 component, alpha subunit (EC 1.2.4.1), similar to many e.g. Q9Y8I5|PDHA from Halobacterium volcanii (Haloferax volcanii) (368 aa) FASTA scores: opt: 961, E(): 1.3e-52, (45.6% identity in 351 aa overlap); BAB40585 from Bacillus sp. UTB2301 (356 aa) FASTA scores: opt: 947, E(): 9.1e-52, (43.1% identity in 355 aa overlap); Q9KG99|BH0213 from Bacillus halodurans (367 aa), FASTA scores: opt: 896, E(): 1.4e-48, (42.65% identity in 340 aa overlap); etc. Also similar to several PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASES E1,BETA SUBUNIT (EC 1.2.4.4), alternate name : 2-oxoisovalerate dehydrogenase, e.g. Q53592|BKDA from Streptomyces avermitilis (381 aa), FASTA scores: opt: 980,E(): 8.5e-54, (45.65% identity in 370 aa overlap); etc.	Q7TYG0	No								IPR001017,IPR017596	Q7TYG0	A0A1R3Y1D9									
NC_002945.3	Mycobrowser_v4	CDS	2779152	2779973	.	-	0	Mb2526c	citE		PROBABLE CITRATE (PRO-3S)-LYASE (BETA SUBUNIT) CITE (CITRASE) (CITRATASE) (CITRITASE) (CITRIDESMOLASE) (CITRASE ALDOLASE)	Mb2526c, citE, len: 273 aa. Equivalent to Rv2498c,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Probable citE,citrate lyase, beta subunit (EC 4.1.3.6), similar to others e.g. Q9S3L3|CITE from Corynebacterium glutamicum (Brevibacterium flavum) (217 aa), FASTA scores: opt: 565,E(): 1.5e-28, (41.85% identity in 215 aa overlap); Q9HRM8|CITE|VNG0627G from Halobacterium sp. strain NRC-1 (303 aa), FASTA scores: opt: 535, E(): 1.5e-26, (41.65% identity in 276 aa overlap); Q9S2U9|SC4G6.02 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 426,E(): 1e-19, (37.6% identity in 274 aa overlap); P77770|CILB_ECOLI from Escherichia coli (307 aa), FASTA scores: opt: 265, E(): 1.5e-10, (32.8% identity in 265 aa overlap); etc. Also similar to Rv3075c|MTCY22D7.06 from Mycobacterium tuberculosis, FASTA score: (35.2% identity in 264 aa overlap).	Q7TYF9	No								IPR005000,IPR011206,IPR015813	Q7TYF9	A0A1R3Y1E1									
NC_002945.3	Mycobrowser_v4	CDS	2818548	2819468	.	-	0	Mb2557c	mrr		PROBABLE RESTRICTION SYSTEM PROTEIN MRR	Mb2557c, mrr, len: 306 aa. Equivalent to Rv2528c,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 306 aa overlap). Probable mrr,restriction system protein, similar to other mrr proteins e.g. Q9RWS8|DR0587|MRR from Deinococcus radiodurans (306 aa), FASTA scores: opt: 776, E(): 4.2e-40, (40.45% identity in 309 aa overlap); P24202|MRR_ECOLI|B4351 from Escherichia coli strain K12 (304 aa), FASTA scores: opt: 647, E(): 2.9e-32, (35.25% identity in 309 aa overlap); Q9RX07|DR0508 from Deinococcus radiodurans (336 aa), FASTA scores: opt: 456, E(): 1.3e-20, (37.3% identity in 319 aa overlap); etc.	Q7TYD4	No								IPR007560,IPR011335,IPR011856,IPR025745	Q7TYD4	A0A1R3Y1G5									
NC_002945.3	Mycobrowser_v4	CDS	2780524	2781708	.	-	0	Mb2528c	fadE19		POSSIBLE ACYL-COA DEHYDROGENASE FADE19 (MMGC)	Mb2528c, fadE19, len: 394 aa. Equivalent to Rv2500c, len: 394 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 394 aa overlap). Possible fadE19 (alternate gene name: mmgC), acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9XCG6|ACDH from Streptomyces coelicolor (386 aa), FASTA scores: opt: 1714, E(): 1.1e-98, (69.45% identity in 383 aa overlap); Q9XCG5|ACDH from Streptomyces avermitilis (386 aa), FASTA scores: opt: 1713, E(): 1.3e-98, (70.0% identity in 383 aa overlap); Q9L7W5|FENK from Bacillus subtilis (370 aa), FASTA scores: opt: 1094, E(): 2.3e-60,(48.4% identity in 372 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TYF7	No	lipid metabolism							IPR006089,IPR006091,IPR009075,IPR009100,IPR013786	Q7TYF7	A0A1R3Y1C1				Rv2500c		Rv2500c			
NC_002945.3	Mycobrowser_v4	CDS	2781713	2783677	.	-	0	Mb2529c	accA1		PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) ACCA1: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)	Mb2529c, accA1, len: 654 aa. Equivalent to Rv2501c,len: 654 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 654 aa overlap). Probable accA1 (alternate gene name: bccA), acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)],similar to others eg Q9L076|FABG from Streptomyces coelicolor (646 aa), FASTA scores: opt: 2071, E(): 1e-113,(57.8% identity in 659 aa overlap); AAK24139|Q9A6C6|CC2168 from Caulobacter crescentus (654 aa), FASTA scores: opt: 1754, E(): 3.7e-95, (47.2% identity in 661 aa overlap); etc. Contains PS00188 Biotin-requiring enzymes attachment site, PS00866 Carbamoyl-phosphate synthase subdomain signature 1, and PS00867 Carbamoyl-phosphate synthase subdomain signature 2.	X2BLJ9,P0A509	No									X2BLJ9,P0A509	P0A509									
NC_002945.3	Mycobrowser_v4	CDS	2783682	2785271	.	-	0	Mb2530c	accD1		PROBABLE ACETYL-/PROPIONYL-COA CARBOXYLASE (BETA SUBUNIT) ACCD1	Mb2530c, accD1, len: 529 aa. Equivalent to Rv2502c,len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 529 aa overlap). Probable accD1,acetyl-/propionyl-CoA carboxylase (beta subunit) (EC 6.4.1.-), similar, but with N-terminus shorter, to Q9L077|ACCD1 from Streptomyces coelicolor (538 aa), FASTA scores: opt: 2747, E(): 1.9e-159, (77.9% identity in 516 aa overlap). Also similar to others e.g. AAK24141 CC2170 from Caulobacter crescentus (530 aa), FASTA scores: opt: 2413, E(): 3.8e-139, (69.4% identity in 529 aa overlap); BAB54131|MLL7731 from Rhizobium loti (537 aa), FASTA scores: opt: 2399, E(): 2.7e-138, (67.4% identity in 527 aa overlap); etc. COULD BELONG TO THE ACCD/PCCB FAMILY.	Q7TYF6	No								IPR000022,IPR011762,IPR011763	Q7TYF6	A0A1R3Y277									
NC_002945.3	Mycobrowser_v4	CDS	2785268	2785924	.	-	0	Mb2531c	scoB		PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE (BETA SUBUNIT) SCOB (3-OXO-ACID:COA TRANSFERASE) (OXCT B) (SUCCINYL CoA:3-OXOACID CoA-TRANSFERASE)	Mb2531c, scoB, len: 218 aa. Equivalent to Rv2503c,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Probable scoB, 3-oxo acid:CoA transferase, beta subunit (succinyl-CoA:3-ketoacid-CoA transferase) (EC 2.8.3.5). Highly similar to others e.g. Q9XAM8|SC4C6.12c from Streptomyces coelicolor (217 aa), FASTA scores: opt: 1048,E(): 2.6e-60, (73.9% identity in 207 aa overlap); Q9XD82|PCAJ from Streptomyces sp. 2065 (214 aa), FASTA scores: opt: 1031, E(): 3.2e-59, (70.8% identity in 209 aa overlap); AAK53493|LPSJ from Xanthomonas campestris (pv. campestris) (212 aa), FASTA scores: opt: 886, E(): 6.6e-50, (62.5% identity in 208 aa overlap); P42316|SCOB_BACSU from Bacillus subtilis (216 aa), FASTA scores: opt: 820, E(): 1.2e-45, (58.2% identity in 201 aa overlap); etc. BELONGS TO THE 3-OXOACID COA-TRANSFERASE SUBUNIT B FAMILY.	X2BL86,P63651	No									X2BL86,P63651	P63651									
NC_002945.3	Mycobrowser_v4	CDS	2785921	2786667	.	-	0	Mb2532c	scoA		PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE (ALPHA SUBUNIT) SCOA (3-OXO ACID:CoA TRANSFERASE) (OXCT A) (SUCCINYL-COA:3-OXOACID-COENZYME A TRANSFERASE)	Mb2532c, scoA, len: 248 aa. Equivalent to Rv2504c,len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Probable scoA,succinyl-CoA:3-ketoacid-Coenzyme A transferase, alpha subunit (3-oxo acid:CoA transferase) (EC 2.8.3.6). Highly similar to others e.g. Q9XAM7|SC4C6.13c from Streptomyces coelicolor (260 aa), FASTA scores: opt: 1130, E(): 2.2e-64, (69.9% identity in 249 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA scores: opt: 1121, E(): 8.1e-64, (69.5% identity in 249 aa overlap); etc. BELONGS TO THE 3-OXOACID COA-TRANSFERASE SUBUNIT A FAMILY.	X2BKZ9,P63649	No									X2BKZ9,P63649	P63649									
NC_002945.3	Mycobrowser_v4	CDS	2786750	2788393	.	-	0	Mb2533c	fadD35		PROBABLE FATTY-ACID-COA LIGASE FADD35 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb2533c, fadD35, len: 547 aa. Equivalent to Rv2505c, len: 547 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 547 aa overlap). Probable fadD35, fatty-acid-CoA synthetase (EC 6.2.1.-),highly similar to many e.g. Q9Z5A6|SC2G5.17 from Streptomyces coelicolor (541 aa), FASTA scores: opt: 2202,E(): 8e-131, (61.55% identity in 528 aa overlap); Q9F9U4|FADD from Pseudomonas stutzeri (Pseudomonas perfectomarina), FASTA scores: opt: 1551, E(): 7.3e-90,(55.55% identity in 551 aa overlap); Q987S7|MLR6932 from Rhizobium loti (Mesorhizobium loti) (590 aa), FASTA scores: opt: 1453, E(): 1.1e-83, (50.7% identity in 564 aa overlap); etc.	Q7TYF5	No	lipid metabolism							IPR000873,IPR025110	Q7TYF5	A0A1R3Y1C6				Rv2505c		Rv2505c			
NC_002945.3	Mycobrowser_v4	CDS	3445580	3445894	.	-	0	Mb3149c	Mb3149c		HYPOTHETICAL PROTEIN	Mb3149c, -, len: 104 aa. Equivalent to Rv3126c,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Hypothetical unknown protein. Shortened version of MTCY164.36c, avoiding overlap.	Q7TX75,A0A1R3Y521	No	conserved hypotheticals			A0A1R3Y521					Q7TX75					Rv3126c		Rv3126c			
NC_002945.3	Mycobrowser_v4	CDS	2793954	2794601	.	+	0	Mb2539	orn		oligoribonuclease orn	Mb2539, orn, len: 215 aa. Equivalent to Rv2511,len: 215 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 215 aa overlap). Probable orn,oligoribonuclease (EC 3.1.-.-), equivalent to O07708|ORN_MYCLE|ORN|ML0427|MLCL383.34c OLIGORIBONUCLEASE from Mycobacterium leprae (215 aa), FASTA scores: opt: 1170, E(): 3.5e-65, (84.5% identity in 213 aa overlap). Also highly similar to many e.g. P57667|ORN_STRGR|ORNA from Streptomyces griseus (201 aa), FASTA scores: opt: 807, E(): 7.7e-43, (59.0% identity in 200 aa overlap); ORN_STRCO|ORNA|2SC13.01 from Streptomyces coelicolor (200 aa), FASTA scores: opt: 799, E(): 2.4e-42, (59.7% identity in 201 aa overlap); P39287|ORN_ECOLI|B4162 from Escherichia coli strain K12 (180 aa), FASTA scores: opt: 519, E(): 3.9e-25, (47.4% identity in 173 aa overlap); etc. BELONGS TO THE OLIGORIBONUCLEASE FAMILY.	X2BLK7,P65598	No	intermediary metabolism and respiration								X2BLK7,P65598	P65598				Rv2511		Rv2511			
NC_002945.3	Mycobrowser_v4	tRNA	2794651	2794723	.	+	0	hisT	hisT		tRNA-His	hisT, len: 73 nt. Equivalent to hisT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-His, anticodon gtg.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2800906	2802132	.	-	0	Mb2547c	ldtb		probable l,d-transpeptidase ldtb	Mb2547c, lppS, len: 408 aa. Equivalent to Rv2518c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Probable lppS,conserved lipoprotein, highly similar to O07707|MLCL383.3 HYPOTHETICAL 43.6 KDA PROTEIN from Mycobacterium leprae (407 aa), FASTA scores: opt: 2300, E(): 1.2e-130, (82.5% identity in 406 aa overlap); Q9CCU5|LPPS|ML0426 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (404 aa), FASTA scores: opt: 2279, E(): 2.3e-129, (82.4% identity in 403 aa overlap); and Q9CB49|ML2446 POSSIBLE LIPOPROTEIN from Mycobacterium leprae (441 aa), FASTA scores: opt: 736,E(): 8.4e-37, (35.6% identity in 399 aa overlap). Also similar to other proteins from several organisms e.g. Q9X811|SC6G10.26c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (424 aa), FASTA scores: opt: 867,E(): 1.1e-44, (32.25% identity in 403 aa overlap); Q9L1E8|SC3D11.14 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 737, E(): 7e-37,(32.95% identity in 413 aa overlap); Q9KYV1|SCE22.11 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (407 aa), FASTA scores: opt: 721, E(): 6.2e-36, (33.5% identity in 400 aa overlap). And similar to several hypothetical mycobacterial proteins e.g. Q11149|Y483_MYCTU|Rv0483|MT0501|MTCY20G9.09 (451 aa),FASTA scores: opt: 763, E(): 2.1e-38, (34.85% identity in 402 aa overlap). Has very long signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TYE3	No								IPR005490	Q7TYE3	A0A1R3Y1G0									
NC_002945.3	Mycobrowser_v4	tRNA	2802291	2802363	.	+	0	lysU	lysU		tRNA-Lys	lysU, len: 73 nt. Equivalent to lysU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Lys, anticodon ctt.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2804481	2804954	.	+	0	Mb2550	bcp		PROBABLE BACTERIOFERRITIN COMIGRATORY PROTEIN BCP	Mb2550, bcp, len: 157 aa. Equivalent to Rv2521,len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 157 aa overlap). Probable bcp,bacterioferritin comigratory protein, equivalent to O07705|BCP|ML0424 from Mycobacterium leprae (161 aa),FASTA scores: opt: 829, E(): 6.8e-46, (79.6% identity in 157 aa overlap). Also highly similar to Q9KZQ2|SCE6.38 HYPOTHETICAL 16.8 KDA PROTEIN Streptomyces coelicolor (155 aa), FASTA scores: opt: 727, E(): 2e-39, (69.5% identity in 154 aa overlap); P23480|AAG57590|BCP_ECOLI|B2480|BAB36765|Z3739|ECS3342 BACTERIOFERRITIN COMIGRATORY PROTEIN from Escherichia coli strain K12 (156 aa), FASTA scores: opt: 513, E(): 8.3e-26,(48.3% identity in 149 aa overlap); Q9RW23|DR0846 BACTERIOFERRITIN COMIGRATORY PROTEIN from Deinococcus radiodurans (175 aa), FASTA scores: opt: 465, E(): 1e-22,(46.5% identity in 157 aa overlap); P44411|BCP_HAEIN|HI0254 BACTERIOFERRITIN COMIGRATORY PROTEIN from Haemophilus influenzae (155 aa), FASTA scores: opt: 453, E(): 5.3e-22, (47.5% identity in 139 aa overlap); etc. Also similar to Mycobacterium tuberculosis Rv1608c|MTV046.06|bcpB and Rv2238c|MTCY427.19c|hpE.	Q7TYE0	No	virulence, detoxification, adaptation							IPR000866,IPR012336	Q7TYE0	A0A1R3Y297				Rv2521		Rv2521			
NC_002945.3	Mycobrowser_v4	CDS	2836313	2836690	.	+	0	Mb2578	vapc19		possible toxin vapc19	Mb2578, -, len: 125 aa. Equivalent to Rv2548, len: 125 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 125 aa overlap). Conserved hypothetical protein. Some similarity to various proteins e.g. P71665|Rv1397c|MTCY21B4.14c HYPOTHETICAL 15.0 KDA PROTEIN from Mycobacterium tuberculosis (133 aa), FASTA scores: opt: 265, E(): 7.1e-12, (42.3% identity in 123 aa overlap); Q97WY5|SSO1975 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (125 aa), FASTA scores: opt: 131,E(): 0.018, (30.0% identity in 110 aa overlap); O52285|YLE HYPOTHETICAL 14.9 KDA PROTEIN from Agrobacterium radiobacter (133 aa), FASTA scores: opt: 128, E(): 0.03,(32.8% identity in 125 aa overlap); etc.	Q7TYB7	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TYB7	A0A1R3Y3N1				Rv2548		Rv2548			
NC_002945.3	Mycobrowser_v4	CDS	2806335	2806727	.	-	0	Mb2552c	acpS		HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIER PROTEIN]PANTETHEINEPHOSPHOTRANSFERASE)	Mb2552c, acpS, len: 130 aa. Equivalent to Rv2523c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). acpS, holo-[Acyl Carrier Protein] synthase (EC 2.7.8.7) (see citation below), equivalent to Q9X7E3|ACPS_MYCLE|ML1192|MLCB458.07 HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE from Mycobacterium leprae (130 aa), FASTA scores: opt: 732, E(): 5.5e-42,(87.5% identity in 128 aa overlap). Also similar to others e.g. O86785|ACPS_STRCO|SC6G4.22c from Streptomyces coelicolor (123 aa), FASTA scores: opt: 204, E(): 6.6e-07,(36.7% identity in 139 aa overlap); Q9KPB6|VC2457 from Vibrio cholerae (126 aa), FASTA scores: opt: 163, E(): 0.00036, (32.55% identity in 129 aa overlap); P24224|ACPS_ECOLI|DPJ|B2563 from Escherichia coli strain K12 (125 aa), FASTA scores: opt: 151, E(): 0.0022, (30.55% identity in 131 aa overlap); etc. BELONGS TO THE ACPS FAMILY.	X2BL12,P0A4W9	No									X2BL12,P0A4W9	P0A4W9									
NC_002945.3	Mycobrowser_v4	CDS	2806920	2816129	.	-	0	Mb2553c	fas		PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	Mb2553c, fas, len: 3069 aa. Equivalent to Rv2524c,len: 3069 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 3069 aa overlap). Probable fas,Fatty Acid Synthase (EC 2.3.1.-), equivalent to Q9X7E2|FAS|ML1191 PUTATIVE TYPE I FATTY ACID SYNTHASE from Mycobacterium leprae (3076 aa), FASTA scores: opt: 17484,E(): 0, (85.8% identity in 3081 aa overlap). Also similar to others e.g. Q04846|FAS|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa),FASTA scores: opt: 3981, E(): 5.5e-203, (49.8% identity in 3099 aa overlap); Q48926|FAS from Mycobacterium bovis (2796 aa), FASTA scores: opt: 2098, E(): 3.9e-103, (59.7% identity in 2862 aa overlap) (see first citation below); P34731|FAS1_CANAL FATTY ACID SYNTHASE SUBUNIT BETA from Candida albicans (Yeast) (2037 aa), FASTA scores: opt: 955, E(): 1.3e-42, (27.4% identity in 1926 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00606 Beta-ketoacyl synthases active site.	Q7TYD8	No								IPR001227,IPR002539,IPR003965,IPR013565,IPR013785,IPR014030,IPR014031,IPR014043,IPR016035,IPR016038,IPR016039,IPR016040	Q7TYD8	A0A1R3Y1F3									
NC_002945.3	Mycobrowser_v4	CDS	2838659	2839441	.	-	0	Mb2582c	aroE		PROBABLE SHIKIMATE 5-DEHYDROGENASE AROE (5-DEHYDROSHIKIMATE REDUCTASE)	Mb2582c, aroE, len: 260 aa. Equivalent to Rv2552c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 260 aa overlap). Probable aroE,shikimate 5-dehydrogenase (EC 1.1.1.25), equivalent to Q9CCS7|AROE|ML0515 PUTATIVE SHIKIMATE 5-DEHYDROGENASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1452,E(): 1.8e-77, (81.5% identity in 270 aa overlap). Also highly similar, but longer 101 aa, to Q9KH59|AROE PUTATIVE SHIKIMATE DEHYDROGENASE (FRAGMENT) from Mycobacterium marinum (148 aa), FASTA scores: opt: 729, E(): 1.3e-35,(76.35% identity in 148 overlap); Q9F7W3|AROE from Mycobacterium ulcerans (148 aa), FASTA scores: opt: 718,E(): 5.9e-35, (75.7% identity in 148 aa overlap). And also similar to to others e.g. Q9KXQ2|AROE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 572, E(): 2.8e-26,(43.4% identity in 251 aa overlap); Q98DY3|MLR4492 from Rhizobium loti (Mesorhizobium loti) (280 aa), FASTA scores: opt: 385, E(): 2.2e-15, (34.85% identity in 284 aa overlap); P74591|AROE_SYNY3|SLR1559 from Synechocystis sp. strain PCC 6803 (290 aa), FASTA scores: opt: 347, E(): 3.7e-13, (30.9% identity in 275 aa overlap); P15770|AROE_ECOLI|B3281 from Escherichia coli strain K12 (272 aa), FASTA scores: opt: 230, E(): 7.7e-08, (29.5% identity in 251 aa overlap); etc. BELONGS TO THE SHIKIMATE DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (t-*) leads to a shorter product compared to Mycobacterium tuberculosis strain H37Rv (260 aa versus 269 aa).	Q7TYB3	No								IPR006151,IPR010110,IPR013708,IPR016040	Q7TYB3	A0A1R3Y1J1									
NC_002945.3	Mycobrowser_v4	CDS	2821064	2821483	.	-	0	Mb2559c	vapc39		possible toxin vapc39. contains pin domain.	Mb2559c, -, len: 139 aa. Equivalent to Rv2530c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Conserved hypothetical protein, highly similar to two HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis (strains H37Rv and CDC1551): O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 380, E(): 3.6e-19, (48.0% identity in 125 aa overlap); and O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: 286, E(): 9.3e-13, (41.35% identity in 133 aa overlap); and similar to others e.g. O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 158, E(): 0.00048, (39.55% identity in 129 aa overlap). Also some similarity with CAC48798|SMB20412 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (54 aa), FASTA scores: opt: 184, E(): 3.7e-06, (53.85% identity in 52 aa overlap); and CAC48797|SMB20411 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (82 aa), FASTA scores: opt: 170, E(): 4.8e-05, (44.45% identity in 63 aa overlap).	Q7TYD2	No	virulence, detoxification, adaptation							IPR002716,IPR006226,IPR022907	Q7TYD2	A0A1R3Y3K9				Rv2530c		Rv2530c			
NC_002945.3	Mycobrowser_v4	CDS	2821480	2821704	.	-	0	Mb2559Ac	vapb39		possible antitoxin vapb39	Mb2559Ac, -, len: 74 aa. Equivalent to Rv2530A,len: 74 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 74 aa overlap). Conserved hypothetical protein, similar to Q9CCR7|ML0525 HYPOTHETICAL PROTEIN from Mycobacterium leprae (58 aa), FASTA scores: opt: 179,E(): 1.8e-06, (63.65% identity in 44 aa overlap). Highly similar to O53218|Rv2493 from Mycobacterium tuberculosis (73 aa), FASTA scores: opt: 240, E(): 5.7e-11, (56.75% identity in 74 aa overlap); and Q92WE1|RB0399|SMB20413 HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti)p lasmid pSymB (megaplasmid 2) (75 aa), FASTA scores: opt: 226, E(): 6.5e-10, (56.00% identity in 75 aa overlap).	Q7TYD1	No	virulence, detoxification, adaptation								Q7TYD1	A0A1R3Y2A5				Rv2530A		Rv2530A			
NC_002945.3	Mycobrowser_v4	CDS	2825051	2825521	.	-	0	Mb2562c	nusB		N UTILIZATION SUBSTANCE PROTEIN NUSB (NUSB PROTEIN)	Mb2562c, nusB, len: 156 aa. Equivalent to Rv2533c,len: 156 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 156 aa overlap). nusB, N utilization substance protein (see citation below), equivalent to Q9CCR9|NUSB_MYCLE|ML0523 N UTILIZATION SUBSTANCE PROTEIN B from Mycobacterium leprae (190 aa), FASTA scores: opt: 749, E(): 2.6e-41, (75.7% identity in 148 aa overlap). Also highly similar to others e.g. Q9KXR0|SC9C5.14 from Streptomyces coelicolor (142 aa), FASTA scores: opt: 358,E(): 2.7e-16, (45.0% identity in 140 aa overlap); P54520|NUSB_BACSU from Bacillus subtilis (131 aa), FASTA scores: opt: 315, E(): 1.5e-13, (39.55% identity in 129 aa overlap); O83979|NUSB_TREPA|TP1015 from Treponema pallidum (141 aa), FASTA scores: opt: 268, E(): 1.6e-10, (36.95% identity in 138 aa overlap); etc. BELONGS TO THE NUSB FAMILY.	X2BL35,Q7TYC8	No									X2BL35,Q7TYC8	Q7TYC8									
NC_002945.3	Mycobrowser_v4	CDS	2825524	2826087	.	-	0	Mb2563c	efp		PROBABLE ELONGATION FACTOR P EFP	Mb2563c, efp, len: 187 aa. Equivalent to Rv2534c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 187 aa overlap). Probable efp,elongation factor P, equivalent to Q9CCS0|EFP|ML0522 ELONGATION FACTOR P from Mycobacterium leprae (187 aa),FASTA scores: opt: 1158, E(): 2.1e-67, (94.1% identity in 186 aa overlap). Also highly similar to many e.g. Q45288|EFP_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (187 aa), FASTA scores: opt: 843,E(): 3.4e-47, (69.5% identity in 187 aa overlap); Q9KXQ9|EFP from Streptomyces coelicolor (188 aa), FASTA scores: opt: 833, E(): 1.5e-46, (67.0% identity in 188 aa overlap); P49778|EFP_BACSU from Bacillus subtilis (185 aa), FASTA scores: opt: 607, E(): 4.6e-32, (47.8% identity in 182 aa overlap); P33398|EFP_ECOLI|B4147 from Escherichia coli strain K12 (187 aa), FASTA scores: opt: 503, E(): 1.8e-27, (42.3% identity in 182 aa overlap); etc. BELONGS TO THE ELONGATION FACTOR P FAMILY.	X2BLM5,P64035	No									X2BLM5,P64035	P64035									
NC_002945.3	Mycobrowser_v4	CDS	2826097	2827215	.	-	0	Mb2564c	pepQ		probable cytoplasmic peptidase pepq	Mb2564c, pepQ, len: 372 aa. Equivalent to Rv2535c,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 372 aa overlap). Probable pepQ,cytoplasmic peptidase (EC 3.4.-.-), equivalent to Q9CCS1|PEPQ|ML0521 PUTATIVE CYTOPLASMIC PEPTIDASE from Mycobacterium leprae (376 aa), FASTA scores: opt: 1954,E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also similar to other peptidases e.g. P54518|YQHT_BACSU PUTATIVE PEPTIDASE (BELONGS TO PEPTIDASE FAMILY M24B) from Bacillus subtilis (353 aa), FASTA scores: opt: 808, E(): 1.6e-39, (39.65% identity in 368 aa overlap); Q9KXQ8|SC9C5.16c PUTATIVE PEPTIDASE from Streptomyces coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39,(43.15% identity in 380 aa overlap); Q9K950|BH2800 XAA-PRO DIPEPTIDASE from Bacillus halodurans (355 aa), FASTA scores: opt: 801, E(): 4.1e-39, (39.45% identity in 365 aa overlap); etc. Note that second part of protein is similar to second part of MTCY49.29c|Rv2089c|MT2150|MTCY49.29c PROBABLE DIPEPTIDASE (EC 3.4.13.-; BELONGS TO PEPTIDASE FAMILY M24B) from Mycobacterium tuberculosis (375 aa) (33.9% identity in 354 aa overlap) BLAST RESULTS: Score: 142 bits (359), E: 4e-33, Identities: 86/224 (38%),Positives: 119/224 (52%), Gaps: 4/224 (1%). COULD BE BELONG TO PEPTIDASE FAMILY M24B.	Q7TYC7	No								IPR000587,IPR000994,IPR001131,IPR001714	Q7TYC7	A0A1R3Y1H0									
NC_002945.3	Mycobrowser_v4	CDS	2834577	2835239	.	+	0	Mb2574	lppB		PROBABLE CONSERVED LIPOPROTEIN LPPB	Mb2574, lppB, len: 220 aa. Equivalent to Rv2544,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). Probable lppB,conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 PUTATIVE LIPOPROTEIN LPPA from Mycobacterium tuberculosis (219 aa),FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TYC1	No	cell wall and cell processes								Q7TYC1	A0A1R3Y1H9				Rv2544		Rv2544			
NC_002945.3	Mycobrowser_v4	CDS	2827945	2828388	.	-	0	Mb2566c	aroD		3-dehydroquinate dehydratase arod (aroq) (3-dehydroquinase) (type ii dhqase)	Mb2566c, aroD, len: 147 aa. Equivalent to Rv2537c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). aroD (alternate gene name: aroQ), 3-dehydroquinate dehydratase (EC 4.2.1.10) (see citation below), equivalent to Q9CCS3|AROD|ML0519 3-DEHYDROQUINATE DEHYDRATASE from Mycobacterium leprae (145 aa), FASTA scores: opt: 803, E(): 3.4e-46, (85.9% identity in 142 aa overlap). Also highly similar to many e.g. P96750|AROQ_CORPS from Corynebacterium pseudotuberculosis (146 aa), FASTA scores: opt: 559, E(): 4.1e-30, (61.05% identity in 136 aa overlap); Q9K949|BH2801 from Bacillus halodurans (145 aa), FASTA scores: opt: 453, E(): 4e-23, (52.15% identity in 138 aa overlap); P54517|AROQ_BACSU|YQHS from Bacillus subtilis (148 aa), FASTA scores: opt: 419, E(): 7.1e-21, (45.3% identity in 139 aa overlap); etc. Contains PS01029 Dehydroquinase class II signature. BELONGS TO THE TYPE-II 3-DEHYDROQUINASE FAMILY.	X2BL19,P0A4Z7	No									X2BL19,P0A4Z7	P0A4Z7									
NC_002945.3	Mycobrowser_v4	CDS	2828385	2829473	.	-	0	Mb2567c	aroB		3-DEHYDROQUINATE SYNTHASE AROB	Mb2567c, aroB, len: 362 aa. Equivalent to Rv2538c,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 362 aa overlap). aroB,3-dehydroquinate synthase (EC 4.2.3.4) (see citation below), equivalent to Q9CCS4|AROB_MYCLE|ML0518 3-DEHYDROQUINATE SYNTHASE from Mycobacterium leprae (361 aa), FASTA scores: opt: 2059, E(): 3.3e-117, (87.25% identity in 361 aa overlap). Also highly similar to many e.g. Q9KXQ6|AROB from Streptomyces coelicolor (363 aa),FASTA scores: opt: 1363, E(): 4e-75, (60.05% identity in 358 aa overlap); Q9X5D2|AROB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (366 aa), FASTA scores: opt: 1154, E(): 1.7e-62, (50.95% identity in 359 aa overlap); P07639|AROB_ECOLI|B3389 from Escherichia coli strain K12 (362 aa), FASTA scores: opt: 771, E(): 2.4e-39,(40.6% identity in 345 aa overlap); etc. BELONGS TO THE DEHYDROQUINATE SYNTHASE FAMILY.	X2BL40,P0A4Z5	No									X2BL40,P0A4Z5	P0A4Z5									
NC_002945.3	Mycobrowser_v4	CDS	2829470	2830000	.	-	0	Mb2568c	aroK		shikimate kinase arok (sk)	Mb2568c, aroK, len: 176 aa. Equivalent to Rv2539c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Probable aroK,shikimate kinase (EC 2.7.1.71) (see citation below),equivalent to Q9CCS5|AROK|ML0517 PUTATIVE SHIKIMATE KINASE from Mycobacterium leprae (199 aa), FASTA scores: opt: 852, E(): 1.3e-42, (79.65% identity in 167 aa overlap). Also highly similar to many e.g. Q9X5D1|AROK_CORG from Corynebacterium glutamicum (Brevibacterium flavum) (169 aa), FASTA scores: opt: 478, E(): 5.4e-21, (47.0% identity in 168 aa overlap); Q9KXQ5|AROK from Streptomyces coelicolor (171 aa), FASTA scores: opt: 465, E(): 3.1e-20,(49.1% identity in 167 aa overlap); P24167|AROK_ECOLI from Escherichia coli strain K12 (172 aa), FASTA scores: opt: 316, E(): 1.3e-11, (38.4% identity in 164 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A, and PS01128 Shikimate kinase signature. BELONGS TO THE SHIKIMATE KINASE FAMILY.	X2BLN0,P0A4Z3	No									X2BLN0,P0A4Z3	P0A4Z3									
NC_002945.3	Mycobrowser_v4	CDS	2837180	2837575	.	-	0	Mb2579c	vapc20		possible toxin vapc20	Mb2579c, -, len:131 aa. Equivalent to Rv2549c, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, showing some similarity to P73415|SLL1715 from Synechocystis sp. strain PCC 6803 (157 aa), FASTA scores: opt: 167, E(): 4.2e-05, (29.45% identity in 129 aa overlap); Q9HHY6|VNG6166H from Halobacterium sp. plasmid pNRC200 strain NRC-1 (144 aa),FASTA scores: opt: 133, E(): 0.011, (29.6% identity in 125 aa overlap); and Q9HSU3|VNG0072H from Halobacterium sp. strain NRC-1 (144 aa), FASTA scores: opt: 113, E(): 0.29,(25.75% identity in 136 aa overlap).	Q7TYB6	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TYB6	A0A1R3Y1S7				Rv2549c		Rv2549c			
NC_002945.3	Mycobrowser_v4	CDS	2830004	2831209	.	-	0	Mb2569c	aroF		PROBABLE CHORISMATE SYNTHASE AROF (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE PHOSPHOLYASE)	Mb2569c, aroF, len: 401 aa. Equivalent to Rv2540c,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Probable aroF (alternate gene name: aroC), chorismate synthase (EC 4.2.3.5), equivalent to Q9CCS6|AROF|ML0516 PUTATIVE CHORISMATE SYNTHASE from Mycobacterium leprae (407 aa),FASTA scores: opt: 2278, E(): 6.2e-123, (88.05% identity in 401 aa overlap). Also highly similar to many e.g. Q9X5D0|AROC_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (410 aa), FASTA scores: opt: 1811,E(): 3e-96, (70.3% identity in 397 aa overlap); Q9KXQ4|AROC_STRCO|AROF|SC9C5.20c from Streptomyces coelicolor (394 aa), FASTA scores: opt: 1710, E(): 1.7e-90, (67.0% identity in 385 aa overlap); Q9KCB7|AROC_BACHD|AROF|BH1656 from Bacillus halodurans (390 aa), FASTA scores: opt: 1196, E(): 3.9e-61, (48.7% identity in 386 aa overlap); etc. Contains PS00788 Chorismate synthase signature 2. BELONGS TO THE CHORISMATE SYNTHASE FAMILY. COFACTOR: REDUCED FLAVIN.	X2BKS6,P63612	No									X2BKS6,P63612	P63612									
NC_002945.3	Mycobrowser_v4	CDS	2833265	2833924	.	+	0	Mb2572	lppA		PROBABLE CONSERVED LIPOPROTEIN LPPA	Mb2572, lppA, len: 219 aa. Equivalent to Rv2543,len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Probable lppA,conserved lipoprotein, highly similar to upstream orf P95009|LPPB|Rv2544|MTCY159.12 PUTATIVE LIPOPROTEIN LPPB from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 1240, E(): 1.1e-73, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TYC3	No	cell wall and cell processes								Q7TYC3	A0A1R3Y1H8				Rv2543		Rv2543			
NC_002945.3	Mycobrowser_v4	CDS	2833921	2834580	.	+	0	Mb2573	lprR		PROBABLE CONSERVED LIPOPROTEIN LPRR	Mb2573, lprR, len: 219 aa. Equivalent to MT2619,len: 219 aa, from Mycobacterium tuberculosis strain CDC1551, (99.55% identity in 219 aa overlap). Also similar to Rv2543 and Rv2544, len: 219 aa and 220 aa, from Mycobacterium tuberculosis strain H37Rv, (88.15% identity in 219 aa overlap and 84.40% identity in 218 aa overlap). See citation below. Rv2543: Probable lppA, conserved lipoprotein, highly similar to upstream ORF P95009|LPPB|Rv2544|MTCY159.12 PUTATIVE LIPOPROTEIN LPPB from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 1240, E(): 1.1e-73, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Rv2544: Probable lppB,conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 PUTATIVE LIPOPROTEIN LPPA from Mycobacterium tuberculosis (219 aa),FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,there is a 656 bp insertion relative to Mycobacterium tuberculosis strain H37Rv.	Q7TYC2	No									Q7TYC2	A0A1R3Y1I1									
NC_002945.3	Mycobrowser_v4	CDS	2835236	2835514	.	+	0	Mb2575	vapb18		possible antitoxin vapb18	Mb2575, -, len: 92 aa. Equivalent to Rv2545, len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Conserved hypothetical protein. C-terminus highly similar to O33300|Rv2758c|MTV002.23c PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: 151, E(): 9.8e-05, (66.65% identity in 45 aa overlap); and Q10771|Rv1560|MT1611|MTCY48.05 PROTEIN from Mycobacterium tuberculosis (72 aa), FASTA scores: opt: 84, E(): 8.2,(46.5% identity in 43 aa overlap).	Q7TYC0	No	virulence, detoxification, adaptation							IPR019239	Q7TYC0	A0A1R3Y1J0				Rv2545		Rv2545			
NC_002945.3	Mycobrowser_v4	CDS	2841223	2843937	.	-	0	Mb2585c	alaS		PROBABLE ALANYL-TRNA SYNTHETASE ALAS (ALANINE--TRNA LIGASE) (ALANINE TRANSLASE) (ALARS)	Mb2585c, alaS, len: 904 aa. Equivalent to Rv2555c,len: 904 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 904 aa overlap). Probable alaS,alanyl-tRNA synthetase (EC 6.1.1.7), equivalent to Q9CCT0|ALAS|ML0512 ALANYL-TRNA SYNTHETASE from Mycobacterium leprae (908 aa), FASTA scores: opt: 5013,E(): 0, (84.65% identity in 907 aa overlap). Also highly similar to many e.g. Q9KXP9|ALAS from Streptomyces coelicolor (890 aa), FASTA scores: opt: 2159, E(): 3.8e-118, (53.45% identity in 907 aa overlap); Q9FFC7 Arabidopsis thaliana (Mouse-ear cress) (954 aa), FASTA scores: opt: 1963, E(): 1.1e-106, (41.1% identity in 925 aa overlap); Q9RS27|DR2300 from Deinococcus radiodurans (890 aa), FASTA scores: opt: 1352, E(): 4.1e-71, (38.05% identity in 915 aa overlap); etc. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BL31,Q7TYB1	No									X2BL31,Q7TYB1	Q7TYB1									
NC_002945.3	Mycobrowser_v4	CDS	2863416	2865251	.	-	0	Mb2602c	aspS		probable aspartyl-trna synthetase asps (aspartate--trna ligase) (asprs) (aspartic acid translase)	Mb2602c, aspS, len: 611 aa. Equivalent to Rv2572c,len: 596 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 595 aa overlap). Probable aspS,aspartyl-tRNA synthetase (EC 6.1.1.12), equivalent to P36429|SYD_MYCLE|ML0501|MLCB1259.19 ASPARTYL-TRNA SYNTHETASE from Mycobacterium leprae (589 aa), FASTA scores: opt: 3534, E(): 1.8e-215, (87.85% identity in 592 aa overlap). Also highly similar to many e.g. O67589|SYD_AQUAE|AQ_1677 from Aquifex aeolicus (603 aa),FASTA scores: opt: 1829, E(): 8.2e-108, (47.5% identity in 598 aa overlap); O32038|SYD_BACSU from Bacillus subtilis (592 aa), FASTA scores: opt: 1732, E(): 1.1e-101, (46.25% identity in 597 aa overlap); P21889|SYD_ECOLI|TLS|B1866 from Escherichia coli strain K12 (590 aa), FASTA scores: opt: 1588, E(): 1.3e-92, (47.35% identity in 581 aa overlap); etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (t-*) omitting a stop codon, leads to a longer protein with a different COOH end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (611 aa versus 596 aa).	X2BLQ7,Q7TYA6	No									X2BLQ7,Q7TYA6	Q7TYA6									
NC_002945.3	Mycobrowser_v4	CDS	2850793	2851785	.	+	0	Mb2593	glnQ		PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER GLNQ	Mb2593, glnQ, len: 330 aa. Equivalent to Rv2564,len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 330 aa overlap). Probable glnQ,glutamine-transport ATP-binding protein ABC transporter (see citation below), highly similar to many e.g. Q9L0J9|SCD40A.12c PUTATIVE ABC-TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (246 aa), FASTA scores: opt: 598, E(): 2.5e-26, (46.35% identity in 218 aa overlap); O54136|SC2E9.11 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 592, E(): 5.1e-26, (46.55% identity in 219 aa overlap); O29244|AF1018 from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 580,E(): 2.4e-25, (42.4% identity in 210 aa overlap); P75831|YBJZ_ECOLI|B0879 from Escherichia coli strain K12 (648 aa), FASTA scores: opt: 555, E(): 1.3e-23, (39.65% identity in 232 aa overlap); etc. Also highly similar to O53618|Rv0073|MTV030.17 ABC-TRANSPORTER ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (330 aa), FASTA scores: opt: 1782, E(): 4.7e-92, (83.65% identity in 330 aa overlap); etc. Shows some similarity to Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium tuberculosis (612 aa) (32.9 % identity in 234 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	X2BKU1,P63402	No	cell wall and cell processes								X2BKU1,P63402	P63402				Rv2564		Rv2564			
NC_002945.3	Mycobrowser_v4	CDS	2871087	2871989	.	+	0	Mb2610	dhaA		POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE HALIDOHYDROLASE)	Mb2610, dhaA, len: 300 aa. Equivalent to Rv2579,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 300 aa overlap). Possible dhaA,haloalkane dehalogenase (EC 3.8.1.5), strictly equivalent to Q9XB14|ISO-RV2579 HALOALKANE DEHALOGENASE (1-chlorohexane halidohydrolase) (EC 3.8.1.5) from Mycobacterium bovis (300 aa), FASTA scores: opt: 2075,E(): 7.1e-125, (99.35% identity in 300 aa overlap); note that only two residues, 120 and 293 are different. Also highly similar to others e.g. Q9ZER0|DHAAF HALOALKANE DEHALOGENASE from Mycobacterium sp strain GP1 (307 aa),FASTA scores: opt: 842, E(): 2.3e-46, (44.95% identity in 298 aa overlap); Q53042|DHAA HALOALKANE DEHALOGENASE from Rhodococcus rhodochrous, and Pseudomonas pavonaceae (293 aa), FASTA scores: opt: 837, E(): 4.5e-46, (44.6% identity in 298 aa overlap); etc. Note that this protein may also be a 1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase (EC 3.8.1.-), because also highly similar to P51698|LINB_PSEPA 1,3,4,6-TETRACHLORO-1,4-CYCLOHEXADIENE HYDROLASE from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (see first citation below) (296 aa), FASTA scores: opt: 1494,E(): 6.8e-88, (69.5% identity in 295 aa overlap). Also shows some similarity with proteins from Mycobacterium tuberculosis e.g. Q50670|YM96_MYCTU|Rv2296|MT2353|MTCY339.14c PUTATIVE HALOALKANE DEHALOGENASE (300 aa), FASTA scores: opt: 302,E(): 5.3e-12, (30.85% identity in 295 aa overlap); and Q50600|YJ33_MYCTU|Rv1833c|MT1881|MTCY1A11.10 HYPOTHETICAL 32.2 KDA PROTEIN (286 aa), FASTA scores: opt: 286, E(): 5.3e-11, (29.85% identity in 288 aa overlap). MAY BE BELONG TO ALPHA/BETA HYDROLASE FOLD FAMILY. Note that previously known as linB.	X2BL44,Q9XB14	No	intermediary metabolism and respiration								X2BL44,Q9XB14	Q9XB14				Rv2579		Rv2579			
NC_002945.3	Mycobrowser_v4	CDS	2872269	2873540	.	-	0	Mb2611c	hisS		probable histidyl-trna synthetase hiss (histidine--trna ligase) (hisrs) (histidine--translase)	Mb2611c, hisS, len: 423 aa. Equivalent to Rv2580c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 423 aa overlap). Probable hisS,histidyl-tRNA synthetase (EC 6.1.1.21), equivalent to P46696|SYH_MYCLE|HISS|ML0494|MLCB1259.12|B1177_C3_248 HISTIDYL-TRNA SYNTHETASE from Mycobacterium leprae (427 aa), FASTA scores: opt: 2380, E(): 2.1e-131, (85.85% identity in 417 aa overlap). Also highly similar to many e.g. Q9KXP2|HISS from Streptomyces coelicolor (425 aa),FASTA scores: opt: 1542, E(): 1.4e-82, (56.0% identity in 418 aa overlap); O32422|SYH_STAAU|HISS from Staphylococcus aureus (420 aa), FASTA scores: opt: 1135, E(): 7.4e-59,(44.9% identity in 412 aa overlap); P04804|SYH_ECOLI|HISS|B2514 from Escherichia coli strain K12 (423 aa), FASTA scores: opt: 1099, E(): 9.4e-57,(43.9% identity in 417 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BL97,P67484	No									X2BL97,P67484	P67484									
NC_002945.3	Mycobrowser_v4	CDS	2874262	2875188	.	+	0	Mb2613	ppiB		PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B PPIB (CYCLOPHILIN) (PPIASE) (ROTAMASE) (PEPTIDYLPROLYL ISOMERASE)	Mb2613, ppiB, len: 308 aa. Equivalent to Rv2582,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 308 aa overlap). Probable ppiB (alternate gene name: ppi), cyclophilin (peptidyl-prolyl cis-trans isomerase) (EC 5.2.1.8), equivalent to P46697|PPIB_MYCLE|PPI|ML0492|MLCB1259.10c|B1177_F3_97 PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B from Mycobacterium leprae (295 aa), FASTA scores: opt: 1423,E(): 1.3e-66, (72.2% identity in 295 aa overlap). Aldo similar to others e.g. Q9KJG8|PPIB PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces lividans (277 aa),FASTA scores: opt: 485, E(): 3.2e-18, (38.35% identity in 292 aa overlap); Q9KXP0|SC9C5.34 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 483, E(): 4.1e-18, (38.35% identity in 292 aa overlap); Q9RT72|DR1893 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Deinococcus radiodurans (350 aa), FASTA scores: opt: 296, E(): 2.2e-08, (29.0% identity in 276 aa overlap); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY.	Q7TYA2	No	information pathways							IPR002130	Q7TYA2	A0A1R3Y1L9				Rv2582		Rv2582			
NC_002945.3	Mycobrowser_v4	CDS	2875274	2877646	.	-	0	Mb2614c	relA		PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'-PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE)	Mb2614c, relA, len: 790 aa. Equivalent to Rv2583c,len: 790 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 790 aa overlap). Probable relA, GTP pyrophosphokinase (EC 2.7.6.5), equivalent to Q49640|RELA_MYCLE|ML0491|MLCB1259.09|B1177_C1_168 PROBABLE GTP PYROPHOSPHOKINASE from Mycobacterium leprae (787 aa),FASTA scores: opt: 4834, E(): 0, (93.4% identity in 790 aa overlap). Also highly similar to others e.g. O87331|RELA_CORGL|RELA|REL from Corynebacterium glutamicum (Brevibacterium flavum) (760 aa), FASTA scores: opt: 3375,E(): 1.6e-196, (67.0% identity in 758 aa overlap); O85709|RELA_STRAT from Streptomyces antibioticus (841 aa),FASTA scores: opt: 3209, E(): 1.9e-186, (63.85% identity in 786 aa overlap); Q9KDH1|RELA|BH1242 from Bacillus halodurans (728 aa), FASTA scores: opt: 2195,E(): 3.8e-125, (45.65% identity in 714 aa overlap); etc. BELONGS TO THE RELA / SPOT FAMILY.	X2BLD0,P66015	No									X2BLD0,P66015	P66015									
NC_002945.3	Mycobrowser_v4	CDS	2877677	2878348	.	-	0	Mb2615c	apt		ADENINE PHOSPHORIBOSYLTRANSFERASE APT (APRT) (AMP DIPHOSPHORYLASE) (AMP PYROPHOSPHORYLASE) (TRANSPHOSPHORIBOSIDASE)	Mb2615c, apt, len: 223 aa. Equivalent to Rv2584c,len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 223 aa overlap). Probable apt, adenine phosphoribosyltransferase (EC 2.4.2.7), similar, but longer in N-terminus, to others e.g. O87330|APT_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (185 aa), FASTA scores: opt: 524, E(): 1.3e-24, (50.95% identity in 159 aa overlap); P52561|APT_STRCO from Streptomyces coelicolor (182 aa), FASTA scores: opt: 503,E(): 2.3e-23, (51.85% identity in 164 aa overlap); P47956|APT_MUSPA|APRT from Mus pahari (Shrew mouse) (180 aa), FASTA scores: opt: 419, E(): 2.5e-18, (44.7% identity in 170 aa overlap); P07672|P09993|P77121|APT_ECOLI|B0469 from Escherichia coli strain K12 (183 aa), FASTA scores: opt: 393, E(): 1.9e-18, (42.6% identity in 162 aa overlap); etc. Contains PS00103 Purine/ pyrimidine phosphoribosyl transferases signature, and PS00144 Asparaginase / glutaminase active site signature 1. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. Nearest initiation codon indicated by homology is TTG at 17426 or GTG at 17465.	X2BL45,P59959	No									X2BL45,P59959	P59959									
NC_002945.3	Mycobrowser_v4	CDS	2880131	2881459	.	-	0	Mb2617c	secF		PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN SECF	Mb2617c, secF, len: 442 aa. Equivalent to Rv2586c,len: 442 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 442 aa overlap). Probable secF,protein-export membrane protein (integral membrane protein), equivalent to P38386|SECF_MYCLE|SECF|ML0488|MLCB1259.06|B1177_C3_239 PROTEIN-EXPORT MEMBRANE PROTEIN from Mycobacterium leprae (471 aa), FASTA scores: opt: 1910, E(): 2.9e-104, (72.15% identity in 456 aa overlap). Also similar to others e.g. Q9AE06|SECF from Corynebacterium glutamicum (Brevibacterium flavum) (403 aa), FASTA scores: opt: 1198,E(): 9.8e-63, (47.1% identity in 399 aa overlap); Q53956|SECF_STRCO|SCL2.05c from Streptomyces coelicolor (373 aa), FASTA scores: opt: 670, E(): 6.4e-32, (39.25% identity in 400 aa overlap); Q55611|SECF_SYNY3|SLR0775 from Synechocystis sp. strain PCC 6803 (315 aa), FASTA scores: opt: 416, E(): 3.8e-17, (33.8% identity in 296 aa overlap); etc. BELONGS TO THE SECD/SECF FAMILY, SECF FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c,SECE|Rv0638, SECF, SECG|Rv1440 AND SECY|Rv0732.	Q7TYA1	No								IPR005665,IPR022645,IPR022646,IPR022813	Q7TYA1	A0A1R3Y3Q8									
NC_002945.3	Mycobrowser_v4	CDS	2888999	2890639	.	+	0	Mb2622	PE_PGRS44		pe-pgrs family protein pe_pgrs44	Mb2622, PE_PGRS44, len: 546 aa. Equivalent to Rv2591, len: 543 aa, from Mycobacterium tuberculosis strain H37Rv, (99.1% identity in 546 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. O53845|Rv0834c|MTV043.26c from Mycobacterium tuberculosis (882 aa), FASTA scores: opt: 1813, E(): 5.8e-66, (55.3% identity in 568 aa overlap). Equivalent to AAK46982 from Mycobacterium tuberculosis strain CDC1551 (505 aa) but longer 38 aa. Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp in-frame insertion (*-ggcggcacc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (546 aa versus 543 aa).	Q7TY98	No								IPR000084	Q7TY98	A0A1R3Y1N3									
NC_002945.3	Mycobrowser_v4	CDS	2881463	2883184	.	-	0	Mb2618c	secD		probable protein-export membrane protein secd	Mb2618c, secD, len: 573 aa. Equivalent to Rv2587c,len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 573 aa overlap).Probable secD,protein-export membrane protein (integral membrane protein), equivalent to P38387|SECD_MYCLE|ML0487|MLCB1259.05|B1177_C1_164 PROTEIN-EXPORT MEMBRANE PROTEIN from Mycobacterium leprae (571 aa), FASTA scores: opt: 2948, E(): 2.6e-97, (80.6% identity in 583 aa overlap). Also similar to others e.g. Q9AE07|SECD from Corynebacterium glutamicum (Brevibacterium flavum) (637 aa), FASTA scores: opt: 1023,E(): 1.9e-29, (44.95% identity in 596 aa overlap); Q53955|SECD_STRCO from Streptomyces coelicolor (570 aa),FASTA scores: opt: 864, E(): 7.2e-24, (38.0% identity in 584 aa overlap); O33517|SECD_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (554 aa), FASTA scores: opt: 551, E(): 7.6e-13, (32.25% identity in 304 aa overlap); etc. Equivalent to AAK46977 from Mycobacterium tuberculosis strain CDC1551 (554 aa) but longer 19 aa. BELONGS TO THE SECD/SECF FAMILY, SECD FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732.	Q7TYA0	No								IPR005791,IPR022645,IPR022646,IPR022813	Q7TYA0	A0A1R3Y2G6									
NC_002945.3	Mycobrowser_v4	CDS	2883294	2883641	.	-	0	Mb2619c	yajC		PROBABLE CONSERVED MEMBRANE PROTEIN SECRETION FACTOR YAJC	Mb2619c, -, len: 115 aa. Equivalent to Rv2588c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Probable yajC,secretion factor, a conserved membrane protein (see first citation below), equivalent to Q49647|YP88_MYCLE|ML0486|MLCB1259.04|B1177_C3_235 HYPOTHETICAL 12.8 KDA PROTEIN from Mycobacterium leprae (114 aa), FASTA scores: opt: 499, E(): 2.7e-26, (77.0% identity in 100 aa overlap). Also similar to other proteins e.g. Q9AE08 HYPOTHETICAL 13.5 KDA PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (121 aa), FASTA scores: opt: 222, E(): 5e-08, (39.8% identity in 103 aa overlap); Q9L292|SCL2.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 203, E(): 1.2e-06, (32.05% identity in 106 aa overlap); Q9CDT0|YWAB UNKNOWN PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (110 aa),FASTA scores: opt: 150, E(): 0.0026, (30.85% identity in 94 aa overlap); etc.	X2BLD3,P65026	No	cell wall and cell processes								X2BLD3,P65026	P65026				Rv2588c		Rv2588c			
NC_002945.3	Mycobrowser_v4	CDS	2883808	2885157	.	+	0	Mb2620	gabT		4-AMINOBUTYRATE AMINOTRANSFERASE GABT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEMIALDEHYDE TRANSAMINASE) (GABA AMINOTRANSFERASE) (GABA-AT)	Mb2620, gabT, len: 449 aa. Equivalent to Rv2589,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable gabT,4-aminobutyrate aminotransferase (EC 2.6.1.9), equivalent to P40829|GABT_MYCLE|ML0485|MLCB1259.03c|B1177_F2_67 4-AMINOBUTYRATE AMINOTRANSFERASE (446 aa), FASTA scores: opt: 2468, E(): 4.5e-141, (83.75% identity in 449 aa overlap). Also highly similar to others e.g. O86823|GABT from Streptomyces coelicolor (444 aa), FASTA scores: opt: 1832, E(): 8e-103, (63.9% identity in 443 aa overlap); AAK79395|CAC1427 from Clostridium acetobutylicum (445 aa),FASTA scores: opt: 1283, E(): 8.4e-70, (45.75% identity in 433 aa overlap); Q9KE66|BH0991 from Bacillus halodurans (443 aa), FASTA scores: opt: 1224, E(): 2.9e-66, (44.55% identity in 431 aa overlap); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE.	X2BL48,P63505	No	intermediary metabolism and respiration								X2BL48,P63505	P63505				Rv2589		Rv2589			
NC_002945.3	Mycobrowser_v4	CDS	2885319	2888825	.	+	0	Mb2621	fadD9		PROBABLE FATTY-ACID-CoA LIGASE FADD9 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb2621, fadD9, len: 1168 aa. Equivalent to Rv2590,len: 1168 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1168 aa overlap). Probable fadD9, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to O69484|FADD9 (alias Q9CCT4|FADD9|ML0484 but longer 14 aa) PUTATIVE ACYL-COA SYNTHETASE from Mycobacterium leprae (1174 aa), FASTA scores: opt: 5247,E(): 0, (68.0% identity in 1178 aa overlap); Q49651|LCLA|B1177_F1_23 PUTATIVE LONG-CHAIN-FATTY-ACID--COA LIGASE from Mycobacterium leprae (827 aa), FASTA scores: opt: 3170, E(): 7.1e-181,(63.9% identity in 770 aa overlap). N-terminal (700 residues) similar to other long chain fatty acid ligases. And C-terminus highly similar to C-terminus of Q9XCF2|PSTB PSTB PROTEIN from Mycobacterium avium (2552 aa), FASTA scores: opt: 2083, E(): 8.4e-116, (40.8% identity in 1150 aa overlap) (and weak similarity on N-terminus); Q49653|POL1|B1177_F2_70 POL1 PROTEIN from Mycobacterium leprae (400 aa), FASTA scores: opt: 2066, E(): 2e-115,(76.25% identity in 404 aa overlap). C-terminal part highly similar to polyketide synthases and peptides synthases (weak similarity on N-terminus) e.g. Q10896|Rv0101|MTCY251.20|NRP PROBABLE PEPTIDE SYNTHETASE from Mycobacterium tuberculosis (2512 aa), FASTA scores: opt: 1988, E(): 3.7e-110, (40.2% identity in 1181 aa overlap); etc. Contains PS00455 putative AMP-binding domain signature, and PS00061 Short-chain alcohol dehydrogenase family signature. SEEMS TO BELONG TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY, AND TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TY99	No								IPR000873,IPR009081,IPR010080,IPR013120,IPR016040,IPR020845	Q7TY99	A0A1R3Y1N0									
NC_002945.3	Mycobrowser_v4	CDS	2890656	2891690	.	-	0	Mb2623c	ruvB		PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVB	Mb2623c, ruvB, len: 344 aa. Equivalent to Rv2592c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable ruvB,Holliday junction binding protein (EC 3.6.1.-) (see first citation below), equivalent to P40833|RUVB_MYCLE|ML0483|B1177_C3_227 HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium leprae (349 aa), FASTA scores: opt: 2059, E(): 2.1e-106, (94.45% identity in 342 aa overlap). Also highly similar to others e.g. Q9AE09|RUVB from Corynebacterium glutamicum (Brevibacterium flavum) (363 aa), FASTA scores: opt: 1651,E(): 6.5e-84, (75.6% identity in 332 aa overlap); Q9L291|RUVB from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1530, E(): 3e-77, (68.2% identity in 343 aa overlap); P08577|RUVB_ECOLI|B1860|Z2912|ECS2570 from Escherichia coli strains K12 and O157:H7 (336 aa), FASTA scores: opt: 1284, E(): 1e-63, (55.45% identity in 330 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE RUVB FAMILY.	X2BKW1,P66754	No									X2BKW1,P66754	P66754									
NC_002945.3	Mycobrowser_v4	CDS	2891687	2892277	.	-	0	Mb2624c	ruvA		PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVA	Mb2624c, ruvA, len: 196 aa. Equivalent to Rv2593c,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable ruvA,Holliday junction binding protein (see citations below),equivalent to P40832|RUVA_MYCLE|ML0482|B1177_C2_188 HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium leprae (203 aa), FASTA scores: opt: 923, E(): 9.9e-50, (76.85% identity in 203 aa overlap). Also highly similar to others e.g. Q9L290|RUVA from Streptomyces coelicolor (201 aa) (201 aa), FASTA scores: opt: 549, E(): 8.2e-27, (47.55% identity in 204 aa overlap); Q9AE10|RUVA from Corynebacterium glutamicum (Brevibacterium flavum) (206 aa), FASTA scores: opt: 440, E(): 4e-20, (47.1% identity in 206 aa overlap); P08576|RUVA_ECOLI|B1861|Z2913|ECS2571 from Escherichia coli strains K12 and O157:H7 (203 aa),FASTA scores: opt: 312, E(): 2.8e-12, (34.85% identity in 201 aa overlap); etc. BELONGS TO THE RUVA FAMILY.	X2BLD5,P66745	No									X2BLD5,P66745	P66745									
NC_002945.3	Mycobrowser_v4	CDS	2892274	2892840	.	-	0	Mb2625c	ruvC		PROBABLE CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE RUVC (HOLLIDAY JUNCTION NUCLEASE) (HOLLIDAY JUNCTION RESOLVASE)	Mb2625c, ruvC, len: 188 aa. Equivalent to Rv2594c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Probable ruvC,Holliday junction resolvase (EC 3.1.22.4) (see citations below), equivalent to P40834|RUVC_MYCLE|ML0481|B1177_C3_226 CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE from Mycobacterium leprae (188 aa),FASTA scores: opt: 984, E(): 2.3e-55, (81.0% identity in 184 aa overlap). Also highly similar to others e.g. Q9AE11|RUVC from Corynebacterium glutamicum (Brevibacterium flavum) (221 aa), FASTA scores: opt: 713,E(): 3.6e-38, (56.9% identity in 188 aa overlap); Q9L289|RUVC_STRCO|SCL2.10c from Streptomyces coelicolor (188 aa), FASTA scores: opt: 704, E(): 1.2e-37, (60.65% identity in 178 aa overlap); P24239|RUVC_ECOLI|B1863 from Escherichia coli strain K12 (172 aa), FASTA scores: opt: 322, E(): 1.6e-13, (38.65% identity in 163 aa overlap); etc. BELONGS TO THE RUVC FAMILY. COFACTOR: MAGNESIUM.	X2BL50,P66761	No									X2BL50,P66761	P66761									
NC_002945.3	Mycobrowser_v4	CDS	2892949	2893194	.	+	0	Mb2626	vapb40		possible antitoxin vapb40	Mb2626, -, len: 81 aa. Equivalent to Rv2595, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Conserved hypothetical protein, showing similarity with various bacterial proteins e.g. O28268|AF2011 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (86 aa), FASTA scores: opt: 120, E(): 0.13, (34.35% identity in 67 aa overlap); CAC46196|SMC01176 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (79 aa), FASTA scores: opt: 119, E(): 0.14, (33.35% identity in 63 aa overlap); P37554|SP5T_BACSU|SPOVT STAGE V SPORULATION PROTEIN T from Bacillus subtilis (178 aa), FASTA scores: opt: 104, E(): 2.9, (51.45% identity in 35 aa overlap); etc. Also similar to O07779|Rv0599c|MTCY19H5.23 hypothetical protein from Mycobacterium tuberculosis (78 aa), FASTA scores: opt: 160, E(): 0.00026, (35.8% identity in 81 aa overlap).	X2BLB8	No	virulence, detoxification, adaptation								X2BLB8	P65028				Rv2595		Rv2595			
NC_002945.3	Mycobrowser_v4	CDS	2931048	2931704	.	+	0	Mb2670	dedA		POSSIBLE TRANSMEMBRANE PROTEIN DEDA	Mb2670, dedA, len: 218 aa. Equivalent to Rv2637,len: 218 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 218 aa overlap). Possible dedA,transmembrane protein, equivalent to Q49642|YQ37_MYCLE|ML0467|MLCL581.27|B1177_C2_172/B1177_C1_ 140 HYPOTHETICAL 23.1 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN, BELONGS TO THE DEDA FAMILY) from Mycobacterium leprae (214 aa), FASTA scores: opt: 1160,E(): 4.4e-64, (82.75% identity in 209 aa overlap); and O69601|Y364_MYCLE|ML0287|MLCB4.30 HYPOTHETICAL PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) (222 aa), FASTA scores: opt: 292, E(): 6.6e-11, (32.25% identity in 189 aa overlap). Also highly similar to other membrane proteins e.g. CAC42863|SCBAC36F5.27c PUTATIVE INTEGRAL MEMBRANE from Streptomyces coelicolor (211 aa), FASTA scores: opt: 837, E(): 2.6e-44, (59.2% identity in 201 aa overlap); Q55705|Y232_SYNY3|SLR0232 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (218 aa),FASTA scores: opt: 415, E(): 1.9e-18, (37.85% identity in 206 aa overlap); Q9RV63|DR1167 DEDA PROTEIN from Deinococcus radiodurans (200 aa); P09548|DEDA_ECOLI|B2317|Z3579|ECS3201 DEDA PROTEIN (DSG-1 PROTEIN) from Escherichia coli strains K12 and O157:H7 (219 aa), BLAST scores: 178, E(): 1.8e-13, Identities = 53/175 (30%); etc. Also similar to O06314|Y364_MYCTU|Rv0364|MT0380|MTCY13E10.26 HYPOTHETICAL 24.5 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Mycobacterium tuberculosis (227 aa), FASTA scores: opt: 293, E(): 5.8e-11, (35.85% identity in 184 aa overlap). BELONGS TO THE DEDA FAMILY.	X2BL80,P63912	No	cell wall and cell processes								X2BL80,P63912	P63912				Rv2637		Rv2637			
NC_002945.3	Mycobrowser_v4	CDS	2895845	2897416	.	+	0	Mb2632	speE		probable spermidine synthase spee (putrescine aminopropyltransferase) (aminopropyltransferase) (spdsy)	Mb2632, speE, len: 523 aa. Equivalent to Rv2601,len: 523 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 523 aa overlap). Probable speE,spermidine synthase (EC 2.5.1.16), highly similar to many e.g. Q9L091|SCC24.26c from Streptomyces coelicolor (531 aa), FASTA scores: opt: 1493, E(): 1.3e-79, (48.45% identity in 514 aa overlap); Q9X8S2|SCH10.33c from Streptomyces coelicolor (554 aa), FASTA scores: opt: 1045,E(): 1.7e-53, (40.55% identity in 525 aa overlap); P09158|SPEE_ECOLI|B0121 from Escherichia coli strain K12 (287 aa), FASTA scores: opt: 368, E(): 2.9e-14, (30.5% identity in 272 aa overlap); etc.	X2BLT1,Q7TY95	No	intermediary metabolism and respiration								X2BLT1,Q7TY95	Q7TY95				Rv2601		Rv2601			
NC_002945.3	Mycobrowser_v4	CDS	2897801	2898241	.	+	0	Mb2634	vapc41		possible toxin vapc41. contains pin domain.	Mb2634, -, len: 146 aa. Equivalent to Rv2602, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 146 aa overlap). Conserved hypothetical protein, some weak similarity with proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O50457|Rv1242|MTV006.14 (143 aa), FASTA scores: opt: 147, E(): 0.0021, (26.25% identity in 141 aa overlap); P95023|Rv2530c|MTCY159.26 (139 aa), FASTA scores: opt: 131, E(): 0.027, (33.35% identity in 135 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 125, E(): 0.072, (26.45% identity in 140 aa overlap).	Q7TY93	No	virulence, detoxification, adaptation							IPR002716,IPR006226,IPR022907	Q7TY93	A0A1R3Y1P7				Rv2602		Rv2602			
NC_002945.3	Mycobrowser_v4	CDS	2899150	2899746	.	-	0	Mb2636c	snop		probable glutamine amidotransferase snop	Mb2636c, -, len: 198 aa. Equivalent to Rv2604c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 198 aa overlap). Conserved hypothetical protein, equivalent (but shorter 21 aa) to Q49637|HISH|B1177_C1_149 HISH PROTEIN (BELONGS TO THE YFL060C/YAAE/HI1648 FAMILY) (alias Q9CCT5|ML0474 HYPOTHETICAL PROTEIN 223 aa) from Mycobacterium leprae (219 aa), FASTA scores: opt: 1069, E(): 1.7e-60, (83.35% identity in 198 aa overlap). Also highly similar to hypothetical proteins or amidotransferases e.g. Q9L287|SCL2.12c HYPOTHETICAL 21.5 KDA PROTEIN from Streptomyces coelicolor (202 aa), FASTA scores: opt: 702,E(): 2.3e-37, (56.75% identity in 192 aa overlap); P37528|YAAE_BACSU HYPOTHETICAL 21.4 KDA PROTEIN from Bacillus subtilis (196 aa), FASTA scores: opt: 608, E(): 1.9e-31, (48.7% identity in 189 aa overlap); Q9KGN5|BH0023 AMIDOTRANSFERASE from Bacillus halodurans (196 aa), FASTA scores: opt: 583, E(): 7.4e-30, (48.7% identity in 195 aa overlap); etc. Also some similarity with several proteins from Mycobacterium tuberculosis e.g. O06589|HIS5_MYCTU|Rv1602|MT1638|MTCY336.02c AMIDOTRANSFERASE (EC 2.4.2.-) (206 aa), FASTA scores: opt: 154, E(): 0.00036, (30.6% identity in 193 aa overlap).	X2BLD1,Q7TY92	No	intermediary metabolism and respiration								X2BLD1,Q7TY92	Q7TY92				Rv2604c		Rv2604c			
NC_002945.3	Mycobrowser_v4	CDS	2907416	2908069	.	-	0	Mb2644c	pgsA1		pi synthase pgsa1 (phosphatidylinositol synthase) (cdp-diacylglycerol--inositol-3-phosphatidyltransferase)	Mb2644c, pgsA1, len: 217 aa. Equivalent to Rv2612c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). Probable pgsA1 (previously known as pgsA), PI synthase/CDP-diacylglyceride--inositol phosphatidyltransferase (EC 2.7.8.11), transmembrane protein, equivalent to O07149|MLCL581.16c|PGSA|ML0454 PUTATIVE PHOSPHATIDYLTRANSFERASE from Mycobacterium leprae (239 aa), FASTA scores: opt: 1141, E(): 4.1e-70, (79.35% identity in 213 aa overlap); and Q9F7Y9|PGSA PHOSPHATIDYLINOSITOL SYNTHASE from Mycobacterium smegmatis (222 aa), FASTA scores: opt: 981, E(): 2.7e-59, (67.3% identity in 217 aa overlap) (see citation below). Also similar to other proteins e.g. Q9L282|SCL2.17c PUTATIVE MEMBRANE TRANSFERASE from Streptomyces coelicolor (241 aa), FASTA scores: opt: 564, E(): 4.9e-31, (43.4% identity in 212 aa overlap); Q9UYD0|PGSA-LIKE|PAB1041 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Pyrococcus abyssi (186 aa),FASTA scores: opt: 264, E(): 8.4e-11, (33.15% identity in 190 aa overlap); Q9HQS2|PGSA|VNG1030G CDP-DIACYLGLYCEROL-GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Halobacterium sp. strain NRC-1 (199 aa), FASTA scores: opt: 249, E(): 9.1e-10,(32.1% identity in 193 aa overlap); etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. Note that in M. smegmatis, the psgA homolog is essential to the survival of the bacteria and seems cannot be compensated by any other enzyme of M. smegmatis.	Q7TY86	No								IPR000462	Q7TY86	A0A1R3Y1Q7									
NC_002945.3	Mycobrowser_v4	CDS	2899754	2900599	.	-	0	Mb2637c	tesB2		PROBABLE ACYL-COA THIOESTERASE II TESB2 (TEII)	Mb2637c, tesB2, len: 281 aa. Equivalent to Rv2605c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 281 aa overlap). Probable tesB2,acyl-CoA thioesterase II (EC 3.1.2.-), highly similar to others e.g. Q98EG9|MLL4250 from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 563,E(): 3.9e-29, (47.75% identity in 287 aa overlap); CAC47767 from Rhizobium meliloti (Sinorhizobium meliloti) (294 aa), FASTA scores: opt: 553, E(): 1.8e-28, (49.3% identity in 280 aa overlap); P23911|TESB_ECOLI|B0452 from Escherichia coli strain K12 (285 aa), FASTA scores: opt: 487, E(): 3.1e-24, (41.9% identity in 277 aa overlap); etc. Also similar to O06135|TESB1|Rv1618|MTCY01B2.10 ACYL-COA THIOESTERASE II from Mycobacterium tuberculosis (300 aa), FASTA scores: opt: 425, E(): 1.1e-21, (34.9% identity in 278 aa overlap). BELONGS TO THE C/M/P THIOESTER HYDROLASE FAMILY.	Q7TY91	No								IPR003703,IPR025652	Q7TY91	A0A1R3Y3T0									
NC_002945.3	Mycobrowser_v4	CDS	2933401	2933859	.	+	0	Mb2674	cadI		CADMIUM INDUCIBLE PROTEIN CADI	Mb2674, cadI, len: 152 aa. Equivalent to Rv2641,len: 152 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 152 aa overlap). cadI, conserved hypothetical protein. Gene induced by cadmium (see first citation below), highly similar to hypothetical proteins e.g. Q9L222|SC1A2.19c from Streptomyces coelicolor (152 aa), FASTA scores: opt: 509, E(): 2.3e-27, (55.05% identity in 149 aa overlap); P45945|YQCK_BACSU from Bacillus subtilis (146 aa), FASTA scores: opt: 295, E(): 5.4e-13, (33.55% identity in 146 aa overlap); and Q98CF8|MLL5167 from Rhizobium loti (Mesorhizobium loti) (124 aa), FASTA scores: opt: 110, E(): 1.3, (31.4% identity in 121 aa overlap). Some similarity with Q10548|Y887_MYCTU|Rv0887c|MT0910|MTCY31.15c from Mycobacterium tuberculosis (152 aa), FASTA scores: opt: 108, E(): 2.1, (25.7% identity in 148 aa overlap).	X2BLI3	No	conserved hypotheticals								X2BLI3	P0A5N7				Rv2641		Rv2641			
NC_002945.3	Mycobrowser_v4	CDS	2900628	2901527	.	-	0	Mb2638c	snzp		possible pyridoxine biosynthesis protein snzp	Mb2638c, -, len: 299 aa. Equivalent to Rv2606c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). Conserved hypothetical protein, equivalent to O07145|YQ06_MYCLE|ML0450|MLCL581.12c HYPOTHETICAL 35.6 KDA PROTEIN from Mycobacterium leprae (307 aa), FASTA scores: opt: 1686, E(): 1.5e-95, (89.7% identity in 291 aa overlap). Also highly similar to other hypothetical proteins (or product of pyroA gene) e.g. Q9L286|SCL2.13c HYPOTHETICAL 32.2 KDA PROTEIN from Streptomyces coelicolor (303 aa), FASTA scores: opt: 1461, E(): 7.6e-82, (76.8% identity in 293 aa overlap); O14027|YEM4_SCHPO|SPAC29B12.04 HYPOTHETICAL 31.4 KDA PROTEIN from Schizosaccharomyces pombe (Fission yeast) (296 aa), FASTA scores: opt: 1318, E(): 3.8e-73, (70.35% identity in 290 aa overlap); Q9UW83|PYROA PROTEIN INVOLVED IN PYRIDOXINE BIOSYNTHESIS from Emericella nidulans (Aspergillus nidulans) (see citation below) (304 aa),FASTA scores: opt: 1288, E(): 2.6e-71, (67.9% identity in 302 aa overlap); etc.	X2BKX8,P60795	No	intermediary metabolism and respiration								X2BKX8,P60795	P60795				Rv2606c		Rv2606c			
NC_002945.3	Mycobrowser_v4	CDS	2901655	2902329	.	+	0	Mb2639	pdxH		PROBABLE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE PDXH (PNP/PMP OXIDASE) (PYRIDOXINEPHOSPHATE OXIDASE) (PNPOX) (PYRIDOXINE 5'-PHOSPHATE OXIDASE)	Mb2639, pdxH, len: 224 aa. Equivalent to Rv2607,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable pdxH,pyridoxinephosphate oxidase (EC 1.4.3.5), equivalent to O33065|PDXH_MYCLE|ML2131|MLCB57.46 PYRIDOXAMINE 5'-PHOSPHATE OXIDASE from Mycobacterium leprae (219 aa),FASTA scores: opt: 1038, E(): 8.3e-61, (67.1% identity in 219 aa overlap). Also similar to others e.g. Q9I4S5|PDXH|PA1049 from Pseudomonas aeruginosa (215 aa),FASTA scores: opt: 608, E(): 1.1e-32, (49.55% identity in 218 aa overlap); Q9K3V7|SCD10.19c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 600, E(): 3.9e-32,(42.3% identity in 234 aa overlap); P28225|PDXH_ECOLI|B1638 from Escherichia coli strain K12 (217 aa), FASTA scores: opt: 533, E(): 8.9e-28, (40.3% identity in 216 aa overlap); etc. BELONGS TO THE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE FAMILY. COFACTOR: FMN.	X2BLE9,P65683	No	intermediary metabolism and respiration								X2BLE9,P65683	P65683				Rv2607		Rv2607			
NC_002945.3	Mycobrowser_v4	CDS	2902503	2904245	.	+	0	Mb2640	PPE42		ppe family protein ppe42	Mb2640, PPE42, len: 580 aa. Equivalent to Rv2608,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 580 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O06828|Rv1430|MTCY493.24c from Mycobacterium tuberculosis (528 aa), FASTA scores: opt: 1004, E(): 5.9e-48, (56.05% identity in 307 aa overlap).	Q7TY90	No								IPR000030,IPR002989,IPR013228	Q7TY90	A0A1R3Y246									
NC_002945.3	Mycobrowser_v4	CDS	2905322	2906458	.	-	0	Mb2642c	pimA		ALPHA-MANNOSYLTRANSFERASE PIMA	Mb2642c, pimA, len: 378 aa. Equivalent to Rv2610c,len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). pimA,alpha-mannosyltransferase (EC 2.4.1.-) (see citations below), equivalent to O07147|MLCL581.14c|ML0452 PUTATIVE GLYCOSYLTRANSFERASE from Mycobacterium leprae (374 aa),FASTA scores: opt: 2044, E(): 8.8e-118, (82.25% identity in 378 aa overlap). N-terminus (from aa 1 to 27) equivalent to Q9FY7 PUTATIVE ALPHA-MANNOSYL TRANSFERASE (FRAGMENT) from Mycobacterium smegmatis (27 aa), BLASTP scores: 57.4 bits (137), E(): 3e-8, Identities = 25/27 (92%), Positives = 27/27 (99%) (see citation below). Also highly similar to Q9L284|SCL2.15c PUTATIVE SUGAR TRANSFERASE from Streptomyces coelicolor (387 aa), FASTA scores: opt: 1222, E(): 1.8e-67, (52.95% identity in 376 aa overlap); and similar in part to various proteins e.g. Q9YA73|APE2066 LONG HYPOTHETICAL N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN from Aeropyrum pernix (392 aa), FASTA scores: opt: 434, E(): 3e-19, (31.5% identity in 378 aa overlap); Q9UZA1|PAB0827 GALACTOSYLTRANSFERASE OR LPS BIOSYNTHESIS RFBU RELATED PROTEIN from Pyrococcus abyssi (371 aa),FASTA scores: opt: 382, E(): 4.3e-16, (28.2% identity in 383 aa overlap); O26275|MTH173 LPS BIOSYNTHESIS RFBU RELATED PROTEIN from Methanothermobacter thermautotrophicus (382 aa), FASTA scores: opt: 372, E(): 1.8e-15, (28.4% identity in 391 aa overlap); etc. Shows also some similarity with O05313|Rv1212c|MTCI364.24c HYPOTHETICAL 41.5 KDA PROTEIN from Mycobacterium tuberculosis (387 aa), FASTA scores: opt: 232, E(): 1.1e -07, (28.4% identity in 402 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	X2BLU2,Q7TY88	No									X2BLU2,Q7TY88	Q7TY88									
NC_002945.3	Mycobrowser_v4	CDS	2908646	2910724	.	-	0	Mb2646c	thrS		PROBABLE THREONYL-TRNA SYNTHETASE THRS (THREONINE-TRNA SYNTHETASE)(ThrRS) (THREONINE-TRNA LIGASE)	Mb2646c, thrS, len: 692 aa. Equivalent to Rv2614c,len: 692 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 692 aa overlap). Probable thrS,threonyl-tRNA synthetase (Threonine--tRNA ligase) (EC 6.1.1.3), equivalent to O07151|SYT_MYCLE|THRS|ML0456|MLCL581.18c THREONYL-TRNA SYNTHETASE from Mycobacterium leprae (702 aa), FASTA scores: opt: 3988, E(): 0, (84.05% identity in 702 aa overlap). Also highly similar to others e.g. Q9L278|THRS from Streptomyces coelicolor (658 aa), FASTA scores: opt: 1982, E(): 5.1e-114, (65.1% identity in 659 aa overlap); P56881|SYT_THETH|THRS from Thermus aquaticus (subsp. thermophilus) (659 aa), FASTA scores: opt: 1551, E(): 1.5e-87, (46.5% identity in 650 aa overlap); P00955|SYT_ECOLI from Escherichia coli (642 aa), FASTA scores: opt: 946, E(): 0, (40.7% identity in 612 aa overl ap); etc. Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. COFACTOR: BINDS 1 ZINC ION (BY SIMILARITY).	X2BLE2,P67583	No									X2BLE2,P67583	P67583									
NC_002945.3	Mycobrowser_v4	CDS	2911057	2912451	.	-	0	Mb2648c	PE_PGRS45		pe-pgrs family protein pe_pgrs45	Mb2648c, PE_PGRS45, len: 464 aa. Equivalent to Rv2615c, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 464 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. P71664|Rv1396c|MTCY21B4.13c from Mycobacterium tuberculosis (576 aa), FASTA scores: opt: 1629, E(): 4.8e-58, (56.65% identity in 482 aa overlap). Equivalent to AAK47006 from Mycobacterium tuberculosis strain CDC1551 (476 aa) but shorter 15 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa).	Q7TY83	No								IPR000084	Q7TY83	A0A1R3Y2J2									
NC_002945.3	Mycobrowser_v4	CDS	3288299	3288505	.	-	0	Mb2999A	Mb2999A		HYPOTHETICAL PROTEIN	Mb2999A, -, len: 68 aa. Identified by de novo proteomics from Mycobacterium bovis strain 2212/97 under exponential conditions. Mb2999A transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BM20	No									X2BM20	UPI0004381ED3									
NC_002945.3	Mycobrowser_v4	CDS	2917056	2917949	.	+	0	Mb2656	TB31.7		universal stress protein family protein tb31.7	Mb2656, TB31.7, len: 297 aa. Equivalent to Rv2623,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 297 aa overlap). TB31.7, conserved hypothetical protein, highly similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA scores: opt: 1076, E(): 1.4e-60, (55.25% identity in 295 aa overlap); O53472|Rv2026c|MTV018.13c (294 aa), FASTA scores: opt: 988, E(): 4.8e-55, (51.5% identity in 295 aa overlap); Q10862|YJ96_MYCTU|Rv1996|MT2052|MTCY39.23c (317 aa), FASTA scores: opt: 688, E(): 4.1e-36, (45.1% identity in 315 aa overlap); etc. Also similar to several Streptomyces proteins e.g. Q9RIZ8|SCJ1.16c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (294 aa), FASTA scores: opt: 407, E(): 2e-18, (32.65% identity in 303 aa overlap); and other bacterial hypothetical proteins e.g. Q9HPP5|VNG1536 from Halobacterium sp (147 aa), FASTA scores: opt: 180, E(): 0.00022, (31.65% identity in 139 aa overlap).	Q7TY75	No								IPR006015,IPR006016,IPR014729	Q7TY75	A0A1R3Y1R2									
NC_002945.3	Mycobrowser_v4	CDS	2920025	2920456	.	-	0	Mb2659c	hrp1		hypoxic response protein 1 hrp1	Mb2659c, -, len: 143 aa. Equivalent to Rv2626c,len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 143 aa overlap). Conserved hypothetical protein, similar to CAC49670|SMB21441 PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE PROTEIN (EC 1.1.1.205) from Rhizobium meliloti (Sinorhizobium meliloti) (120 aa), FASTA scores: opt: 287, E(): 6.6e-12,(43.75% identity in 112 aa overlap) (has its N-terminus shorter 27 aa); AAK78655|CAC0678 CBS DOMAINS from Clostridium acetobutylicum (142 aa), FASTA scores: opt: 276, E(): 3.9e-11, (35.65% identity in 115 aa overlap); Q9K9P0|BH2605 BH2605 PROTEIN from Bacillus halodurans (142 aa), FASTA scores: opt: 276, E(): 3.9e-11, (35.65% identity in 115 aa overlap); etc. Also some similarity to P71737|Rv2406c|MTCY253.14 HYPOTHETICAL 15.1 KDA PROTEIN from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 145, E(): 0.00012, (22.3% identity in 112 aa overlap).	Q7TY72	No	conserved hypotheticals							IPR000644	Q7TY72	A0A1R3Y200				Rv2626c		Rv2626c			
NC_002945.3	Mycobrowser_v4	CDS	2927567	2929903	.	-	0	Mb2667c	PE_PGRS46		pe-pgrs family protein pe_pgrs46	Mb2667c, PE_PGRS46, len: 778 aa. Equivalent to Rv2634c, len: 778 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 778 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. O53553|YZ08_MYCTU|Rv3508|MTV023.15 from Mycobacterium tuberculosis (1901 aa), FASTA scores: opt: 2553, E(): 2.2e-93, (53.8% identity in 866 aa overlap). Equivalent to AAK47026 from Mycobacterium tuberculosis strain CDC1551 (788 aa) but shorter 10 aa.	X2BLW7	No									X2BLW7	P0A691									
NC_002945.3	Mycobrowser_v4	CDS	2934372	2935868	.	+	0	Mb2676	arsC		PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSC	Mb2676, arsC, len: 498 aa. Equivalent to Rv2643,len: 498 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 498 aa overlap). Probable arsC,arsenical resistance transport integral membrane protein,highly similar or similar to others e.g. Q9L1X4|SC3D9.05 POSSIBLE ARSENIC RESISTANCE MEMBRANE TRANSPORT PROTEIN from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (74.3% identity in 358 aa overlap); Q9X8Y0|SCH35.26 PUTATIVE HEAVY METAL RESISTANCE MEMBRANE PROTEIN from Streptomyces coelicolor (369 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (73.8% identity in 359 aa overlap); Q06598|ACR3_YEAST|ACR3|YPR201W|P9677.2 ARSENICAL-RESISTANCE PROTEIN from Saccharomyces cerevisiae (Baker's yeast) (404 aa), FASTA scores: opt: 591, E(): 4e-28, (36.6% identity in 380 aa overlap); etc. BELONGS TO THE ACR3 FAMILY.	Q7TY64	No	cell wall and cell processes							IPR002657,IPR004706,IPR023485	Q7TY64	A0A1R3Y1T7				Rv2643		Rv2643			
NC_002945.3	Mycobrowser_v4	tRNA	2936959	2937030	.	-	0	valT	valT		tRNA-Val	valT, len: 72 nt. Equivalent to valT, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Val, anticodon cac.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	2937215	2937287	.	+	0	glyT	glyT		tRNA-Gly	glyT, len: 73 nt. Equivalent to glyT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Gly, anticodon gcc.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	2937317	2937387	.	+	0	cysU	cysU		tRNA-Cys	cysU, len: 71 nt. Equivalent to cysU, len: 71 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 nt overlap). tRNA-Cys, anticodon gca.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3034732	3035559	.	-	0	Mb2791c	PE27		pe family protein pe27	Mb2791c, PE27, len: 275 aa. Equivalent to Rv2769c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 275 aa overlap). Member of the Mycobacterium tuberculosis PE family, highly similar to many (notably in N-terminal part) e.g. P96361|Rv1040c|MTCY10G2.09 from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 1111, E(): 5.9e-52, (68.55% identity in 283 aa overlap).	Q7TXX4	No								IPR000084,IPR022171	Q7TXX4	A0A1R3Y255									
NC_002945.3	Mycobrowser_v4	CDS	2940375	2941133	.	+	0	Mb2686	clpX'		possible atp-dependent protease atp-binding subunit clpc2	Mb2686, clpX', len: 252 aa. Equivalent to Rv2667,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Possible clpX',ATP-dependent protease atp-binding subunit (EC 3.4.-.-),highly similar to Q9X8L2|SCE9.40 HYPOTHETICAL 27.3 KDA PROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 877, E(): 2.2e-46, (57.25% identity in 255 aa overlap). The second half of the protein is highly similar to N-terminal of several CLP-FAMILY proteins e.g. P24428|CLPC_MYCLE|ML0235 PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium leprae (848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); O06286|CLPC_MYCTU|Rv3596c|MT3703|MTCY07H7B.26 PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); Q9S6T8|SCE94.24c PUTATIVE CLP-FAMILY ATP-BINDING PROTEASE from Streptomyces coelicolor (841 aa), FASTA scores: opt: 303, E(): 5.6e-11, (38.8% identity in 152 aa overlap); etc. Some weak similarity to nearby P71961|MTCY441.33|Rv2664 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (83 aa).	X2BLH2,P0A525	No									X2BLH2,P0A525	P0A525									
NC_002945.3	Mycobrowser_v4	CDS	2945770	2947071	.	+	0	Mb2692	aftc		possible arabinofuranosyltransferase aftc	Mb2692, -, len: 433 aa. Equivalent to Rv2673, len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 433 aa overlap). Possible conserved integral membrane protein, equivalent to MLC1351.25|ML1338 POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (440 aa), FASTA scores: opt: 2410,E(): 5.3e-143, (82.05% identity in 434 aa overlap); and showing some similarity with Q9CBX0|ML1504 PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (430 aa), FASTA scores: opt: 159, E(): 0.014, (24.4% identity in 340 aa overlap). Also similar to Q53873|SC6G4.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (411 aa), FASTA scores: opt: 383, E(): 1.4e-16,(29.6% identity in 422 aa overlap); and with weak similarity with P71061|YVFB HYPOTHETICAL PROTEIN from Bacillus subtilis (396 aa), FASTA scores: opt: 136, E(): 0.36, (24.35% identity in 279 aa overlap); and BAB60134|TVG1014811 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (695 aa), FASTA scores: opt: 133, E(): 0.85,(26.45% identity in 280 aa overlap). Shows also some similarity with O06557|Rv1159|MTCI65.26 HYPOTHETICAL 47.1 KDA PROTEIN from Mycobacterium tuberculosis (431 aa),FASTA scores: opt: 149, E(): 0.059, (22.45% identity in 410 aa overlap); and O53515|Rv2181|MTV021.14 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis (427 aa),FASTA scores: opt: 129, E(): 1, (24.8% identity in 367 aa overlap).	Q7TY51	No	cell wall and cell processes							IPR018584	Q7TY51	A0A1R3Y1U8				Rv2673		Rv2673			
NC_002945.3	Mycobrowser_v4	CDS	2947240	2947650	.	+	0	Mb2693	msrb		probable peptide methionine sulfoxide reductase msrb (protein-methionine-r-oxide reductase) (peptide met(o) reductase)	Mb2693, -, len: 136 aa. Equivalent to Rv2674, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 136 aa overlap). Conserved hypothetical protein, highly similar to various proteins e.g. Q9X828|SC9B1.08 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (135 aa), FASTA scores: opt: 653,E(): 1.8e-37, (71.1% identity in 128 aa overlap); O26807|MTH711 TRANSCRIPTIONAL REGULATOR from Methanothermobacter thermautotrophicus (151 aa), FASTA scores: opt: 533, E(): 2.7e-29, (58.15% identity in 129 aa overlap); Q9C5C8|AT4G21860 HYPOTHETICAL 22.0 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (202 aa),FASTA scores: opt: 490, E(): 2.8e-26, (54.05% identity in 124 aa overlap); P39903|YEAA_ECOLI|B1778|Z2817|ECS2487 HYPOTHETICAL PROTEIN from Escherichia coli strains K12 and O157:H7 (137 aa), FASTA scores: opt: 426, E(): 4.4e-22,(46.8% identity in 126 aa overlap).	Q7TY50	No	intermediary metabolism and respiration							IPR002579,IPR011057,IPR028427	Q7TY50	A0A1R3Y1V0				Rv2674		Rv2674			
NC_002945.3	Mycobrowser_v4	CDS	3005688	3008060	.	-	0	Mb2756c	recA		RECA PROTEIN (RECOMBINASE A) [CONTAINS: ENDONUCLEASE PI-MTUI (MTU RECA INTEIN)].	Mb2756c, recA, len: 790 aa. Equivalent to Rv2737c,len: 790 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 790 aa overlap). recA, recombinase A (EC 3.1.-.-), (see citations below), equivalent to Q59560|RECA_MYCSM RECA PROTEIN from Mycobacterium smegmatis (349 aa), FASTA scores: opt: 1495, E(): 1.9e-79,(93.15% identity in 249 aa overlap); and P35901|RECA_MYCLE|ML0987 RECA PROTEIN from Mycobacterium leprae (711 aa), FASTA scores: opt: 1217, E(): 4.5e-63,(46.7% identity in 814 aa overlap). Also highly similar to many e.g. Q9REV6|RECA_AMYMD from Amycolatopsis mediterranei (Nocardia mediterranei) (348 aa), FASTA scores: opt: 1450, E(): 7.6e-77, (89.25% identity in 251 aa overlap); P42442|RECA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (376 aa), FASTA scores: opt: 1355, E(): 2.6e-71, (76.55% identity in 273 aa overlap); P41054|RECA_STRAM from Streptomyces ambofaciens (372 aa), FASTA scores: opt: 1347, E(): 7.6e-71, (82.1% identity in 246 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00321 recA signature, and PS00881 Protein splicing signature. BELONGS TO THE RECA FAMILY. THIS PROTEIN UNDERGOES A PROTEIN SELF SPLICING THAT INVOLVES A POST-TRANSLATIONAL EXCISION OF THE INTERVENING REGION (INTEIN) FOLLOWED BY PEPTIDE LIGATION. BELONGS TO THE HOMING ENDONUCLEASE FAMILY IN THE INTEIN SECTION.	X2BLS4,P0A5U5	No									X2BLS4,P0A5U5	P0A5U5									
NC_002945.3	Mycobrowser_v4	CDS	2949168	2950526	.	-	0	Mb2696c	hemY		PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	Mb2696c, hemY, len: 452 aa. Equivalent to Rv2677c,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 452 aa overlap). Probable hemY,protoporphyrinogen oxidase (EC 1.3.3.4), equivalent to Q50008|PPOX_MYCLE|HEMY|ML1044 PROTOPORPHYRINOGEN OXIDASE from Mycobacterium leprae (451 aa), FASTA scores: opt: 2211, E(): 8.8e-118, (75.4% identity in 455 aa overlap). Also similar to others e.g. Q9RV99|DR1130 from Deinococcus radiodurans (462 aa), FASTA scores: opt: 523, E(): 2.7e-22, (29.8% identity in 453 aa overlap); O32434|PPOX_PROFR|HEMY from Propionibacterium freudenreichii shermanii (527 aa), FASTA scores: opt: 344,E(): 4e-12, (32.1% identity in 495 aa overlap); P32397|PPOX_BACSU|HEMY|HEMG from Bacillus subtilis (470 aa), FASTA scores: opt: 305, E(): 5.9e-10, (26.8% identity in 463 aa overlap); etc. BELONGS TO THE PROTOPORPHYRINOGEN OXIDASE FAMILY. COFACTOR: CONTAINS ONE FAD PER HOMODIMER.	X2BLI7,P0A5A8	No									X2BLI7,P0A5A8	P0A5A8									
NC_002945.3	Mycobrowser_v4	CDS	2950523	2951596	.	-	0	Mb2697c	hemE		probable uroporphyrinogen decarboxylase heme (uroporphyrinogen iii decarboxylase) (uro-d) (upd)	Mb2697c, hemE, len: 357 aa. Equivalent to Rv2678c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 357 aa overlap). Probable hemE,uroporphyrinogen decarboxylase (EC 4.1.1.37), equivalent to P46809|DCUP_MYCLE|HEME|ML1043 UROPORPHYRINOGEN DECARBOXYLASE from Mycobacterium leprae (357 aa), FASTA scores: opt: 2017, E(): 8.2e-111, (83.75% identity in 357 aa overlap). Also highly similar to many e.g. O69861|DCUP_STRCO|HEME|SC1C3.19 from Streptomyces coelicolor (355 aa), FASTA scores: opt: 1165, E(): 5.6e-61, (58.15% identity in 349 aa overlap); P32395|DCUP_BACSU|HEME from Bacillus subtilis (353 aa),FASTA scores: opt: 859, E(): 4.5e-43, (44.1% identity in 356 aa overlap); Q9RV96|DCUP_DEIRA|HEME|DR1133 from Deinococcus radiodurans (344 aa), FASTA scores: opt: 850,E(): 1.5e-42, (43.0% identity in 349 aa overlap); etc. Equivalent to AAK47067 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but shorter 15 aa. Contains PS00907 Uroporphyrinogen decarboxylase signature 2. BELONGS TO THE UROPORPHYRINOGEN DECARBOXYLASE FAMILY.	X2BLZ0,Q7TY47	No									X2BLZ0,Q7TY47	Q7TY47									
NC_002945.3	Mycobrowser_v4	CDS	2951649	2952479	.	+	0	Mb2698	echA15		PROBABLE ENOYL-COA HYDRATASE ECHA15 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb2698, -, len: 276 aa. Equivalent to Rv2679, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Probable echA15,enoyl-CoA hydratase (EC 4.2.1.17), similar to P53526|ECHC_MYCLE|ECHA12|ML1241|MLCB1610.01|B1170_C2_224 PROBABLE ENOYL-COA HYDRATASE from Mycobacterium leprae (294 aa), FASTA scores: opt: 368, E(): 2.5e-16, (32.15% identity in 277 aa overlap). Also highly similar to Q9RXX1|DR0184 from Deinococcus radiodurans (273 aa), FASTA scores: opt: 993, E(): 2.2e-56, (58.15% identity in 263 aa overlap); and similar to many e.g. Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa), FASTA scores: opt: 396, E(): 3.8e-18, (34.9% identity in 258 aa overlap); O29299|AF0963|FAD-3 from Archaeoglobus fulgidus (259 aa),FASTA scores: opt: 363, E(): 4.7e-16, (30.4% identity in 250 aa overlap); P77467|PAAG_ECOLI|B1394 from Escherichia coli strain W (262 aa), FASTA scores: opt: 357, E(): 1.1e-15, (31.75% identity in 252 aa overlap); etc. Also similar to O53163|ECHC_MYCTU|ECHA12|FADB2|Rv1472|MT1518|MTV007.19 ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (285 aa), FASTA scores: opt: 355, E(): 1.6e-15, (31.3% identity in 265 aa overlap); and O06542|ECHA10|Rv1142c|MTCI65.09c|Z95584 ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (268 aa). Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY.	Q7TY46	No	lipid metabolism							IPR001753,IPR018376	Q7TY46	A0A1R3Y2P7				Rv2679		Rv2679			
NC_002945.3	Mycobrowser_v4	CDS	2957250	2958539	.	+	0	Mb2703	arsA		PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSA	Mb2703, arsA, len: 429 aa. Equivalent to Rv2684,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Probable arsA,arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA PROBABLE INTEGRAL MEMBRANE PROTEIN (antigen 45, a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa), FASTA scores: opt: 2067, E(): 9.9e-118, (74.05% identity in 428 aa overlap); and upstream orf O07187|YQ85_MYCTU|ARSB|Rv2685|MT2759|MTCY05A6.06 PROBABLE INTEGRAL MEMBRANE 45.2 KDA PROTEIN ARSB from Mycobacterium tuberculosis (428 aa), FASTA scores: opt: 2148, E(): 1.3e-122, (76.58% identity in 427 aa overlap). Also highly similar to other proteins e.g. Q9UY19|PAB1107 TRANSPORT PROTEIN from Pyrococcus abyssi (425 aa), FASTA scores: opt: 1109, E(): 8.3e-60, (41.45% identity in 427 aa overlap); O59575|PH1912 HYPOTHETICAL 46.0 KDA PROTEIN from Pyrococcus horikoshii (424 aa), FASTA scores: opt: 1101,E(): 2.5e-59, (41.95% identity in 429 aa overlap); Q9KDI2|BH1231 HYPOTHETICAL 46.0 KDA PROTEIN from Bacillus halodurans (428 aa), FASTA scores: opt: 1018, E(): 2.7e-54, (38.9% identity in 427 aa overlap); etc. BELONGS TO THE NADC/P/PHO87 FAMILY OF TRANSPORTERS, P SUBFAMILY (ARS FAMILY).	X2BL67,P0A607	No	cell wall and cell processes								X2BL67,P0A607	P0A607				Rv2684		Rv2684			
NC_002945.3	Mycobrowser_v4	CDS	2958619	2959905	.	+	0	Mb2704	arsB1		PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSB1	Mb2704, arsB1, len: 428 aa. Equivalent to Rv2685,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 428 aa overlap). Probable arsB1,arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA PROBABLE INTEGRAL MEMBRANE PROTEIN (antigen 45, a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa), FASTA scores: opt: 2048, E(): 7.3e-120, (74.25% identity in 427 aa overlap); and downstream ORF O07186|YQ84_MYCTU|ARSA|Rv2684|MT2758|MTCY05A6.05 PROBABLE INTEGRAL MEMBRANE PROTEIN ARSA from Mycobacterium tuberculosis (429 aa), FASTA scores: opt: 2154, E(): 1.9e-126, (76.8% identity in 427 aa overlap). Also highly similar to other proteins e.g. O59575|PH1912 HYPOTHETICAL 46.0 KDA PROTEIN from Pyrococcus horikoshii (424 aa),FASTA scores: opt: 1075, E(): 1.9e-59, (43.55% identity in 427 aa overlap); Q9UY19|PAB1107 TRANSPORT PROTEIN from Pyrococcus abyssi (425 aa), FASTA scores: opt: 1062, E(): 1.3e-58, (41.8% identity in 428 aa overlap); Q9KDI2|BH1231 HYPOTHETICAL 46.0 KDA PROTEIN from Bacillus halodurans (428 aa), FASTA scores: opt: 993, E(): 2.4e-54, (39.55% identity in 430 aa overlap); etc. BELONGS TO THE NADC/P/PHO87 FAMILY OF TRANSPORTERS, P SUBFAMILY. Note that previously known as arsB.	Q7TY42	No								IPR000802,IPR004680	Q7TY42	A0A1R3Y1W7									
NC_002945.3	Mycobrowser_v4	CDS	2965980	2966663	.	+	0	Mb2710	ceoB		TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOB	Mb2710, ceoB, len: 227 aa. Equivalent to Rv2691,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 227 aa overlap). ceoB (alternate gene name: trkA), TRK system potassium uptake protein (see citation below), highly similar to others e.g. Q53949|TRKA_STRCO|SC2E9.17c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 781, E(): 5.8e-42, (53.2% identity in 220 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 287, E(): 5.3e-11, (27.0% identity in 211 aa overlap); O54141|SC2E9.16c from Streptomyces coelicolor (226 aa), FASTA scores: opt: 269, E(): 7.3e-10, (29.9% identity in 214 aa overlap); etc. Also similar to upstream orf O07194|CEOC|TRKA_MYCTU|TRKA|TRKB|Rv2692|MT2766|MTCY05A6.13 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 259, E(): 3e-09,(26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY.	Q7TY36	No	cell wall and cell processes							IPR003148,IPR006036,IPR006037,IPR016040	Q7TY36	A0A1R3Y2B8				Rv2691		Rv2691			
NC_002945.3	Mycobrowser_v4	CDS	3049500	3050015	.	-	0	Mb2807c	lppU		PROBABLE LIPOPROTEIN LPPU	Mb2807c, lppU, len: 171 aa. Equivalent to Rv2784c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Probable lppU,lipoprotein, sharing no homology with other proteins. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TXV9	No									Q7TXV9	A0A1R3Y465									
NC_002945.3	Mycobrowser_v4	CDS	2966660	2967322	.	+	0	Mb2711	ceoC		TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOC	Mb2711, ceoC, len: 220 aa. Equivalent to Rv2692,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 220 aa overlap). ceoC (alternate gene names: trkA and trkB), TRK system potassium uptake protein (see citation below), highly similar to others e.g. O54141|SC2E9.16c from Streptomyces coelicolor (226 aa),FASTA scores: opt: 870, E(): 9.4e-48, (58.8% identity in 216 aa overlap); Q58505|TRKA_METJA|MJ1105 from Methanococcus jannaschii (218 aa), FASTA scores: opt: 361,E(): 9.7e-16, (29.8% identity in 218 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 326, E(): 1.5e-13, (30.1% identity in 216 aa overlap); etc. Also similar to downstream orf O07193|CEOB|TRKA|Rv2691|MTCY05A6.12 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (227 aa),FASTA scores: opt: 259, E(): 2.6e-09, (26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY.	Q7TY35	No	cell wall and cell processes							IPR003148,IPR006036,IPR006037,IPR016040	Q7TY35	A0A1R3Y1X0				Rv2692		Rv2692			
NC_002945.3	Mycobrowser_v4	CDS	2970319	2970783	.	-	0	Mb2716c	dut		probable deoxyuridine 5'-triphosphate nucleotidohydrolase dut (dutpase) (dutp pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dutp diphosphatase) (deoxyuridine-triphosphatase)	Mb2716c, dut, len: 154 aa. Equivalent to Rv2697c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Probable dut,deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23), equivalent to Q49992|DUT_MYCLE|ML1028 DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE from Mycobacterium leprae (154 aa), FASTA scores: opt: 928,E(): 2.1e-51, (90.25% identity in 154 aa overlap). Also highly similar to others e.g. O54134|DUT_STRCO|SC2E9.09 from Streptomyces coelicolor (183 aa), FASTA scores: opt: 534, E(): 1.2e-26, (56.1% identity in 148 aa overlap); O66592|DUT_AQUAE|AQ_220 from Aquifex aeolicus (150 aa),FASTA scores: opt: 398, E(): 3.3e-18, (48.05% identity in 152 aa overlap); Q9X3X5|DUT_ZYMMO from Zymomonas mobilis (146 aa), FASTA scores: opt: 396, E(): 4.4e-18, (49.0% identity in 147 aa overlap); etc. BELONGS TO THE DUTPASE FAMILY.	X2BLL2,P0A553	No									X2BLL2,P0A553	P0A553									
NC_002945.3	Mycobrowser_v4	CDS	2972499	2973371	.	-	0	Mb2720c	suhB		inositol-1-monophosphatase suhb	Mb2720c, suhB, len: 290 aa. Equivalent to Rv2701c,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 290 aa overlap). Possible suhB,extragenic suppressor protein, equivalent to P46813|SUHB_MYCLE|SUHB|SSYA|ML1024 EXTRAGENIC SUPPRESSOR PROTEIN from Mycobacterium leprae (291 aa), FASTA scores: opt: 1424, E(): 4.9e-78, (77.55% identity in 294 aa overlap). Similar (except at N-terminus) to others e.g. O54128|SUHB from Streptomyces coelicolor (209 aa), FASTA scores: opt: 560, E(): 1.7e-26, (46.95% identity in 213 aa overlap); Q9CNV8|SUHB|PM0315 from Pasteurella multocida (267 aa), FASTA scores: opt: 479, E(): 1.5e-21, (39.3% identity in 234 aa overlap); P44333|SUHB_HAEIN|HI0937 from Haemophilus influenzae (267 aa), FASTA scores: opt: 438,E(): 4.1e-19, (34.7% identity in 248 aa overlap); P22783|SUHB_ECOLI|SSYA|B2533 from Escherichia coli strain K12 (267 aa), FASTA scores: opt: 419, E(): 5.7e-18,(34.45% identity in 267 aa overlap); etc. And also similar to putative myo-inositol-1(or 4)-monophosphatases e.g. Q9S1M1|SPCA from Streptoverticillium netropsis (Streptoverticillium flavopersicus) (266 aa), FASTA scores: opt: 556, E(): 3.6e-26, (45.4% identity in 240 aa overlap); Q9S3X5|SPCA from Streptomyces spectabilis (264 aa), FASTA scores: opt: 502, E(): 6.1e-23, (46.05% identity in 265 aa overlap); CAC47357 from Rhizobium meliloti (Sinorhizobium meliloti) (266 aa), FASTA scores: opt: 452, E(): 6e-20, (38.5% identity in 244 aa overlap); etc. Equivalent to AAK47090 from Mycobacterium tuberculosis strain CDC1551 (277 aa) but longer 13 aa. Contains PS00630 Inositol monophosphatase family signatures 1 and 2 (PS00629 and PS00630). BELONGS TO THE INOSITOL MONOPHOSPHATASE FAMILY.	X2BLB6,P65166	No									X2BLB6,P65166	P65166									
NC_002945.3	Mycobrowser_v4	CDS	2973494	2974291	.	+	0	Mb2721	ppgK		POLYPHOSPHATE GLUCOKINASE PPGK (POLYPHOSPHATE-GLUCOSE PHOSPHOTRANSFERASE)	Mb2721, ppgK, len: 265 aa. Equivalent to Rv2702,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 265 aa overlap). ppgK, polyphosphate glucokinase (EC 2.7.1.2) (see citation below), equivalent,but shorter 60 aa, to Q49988|PPGK_MYCLE|ML1023|U1764FG POLYPHOSPHATE GLUCOKINASE from Mycobacterium leprae (324 aa), FASTA scores: opt: 1411, E(): 5.6e-80, (82.8% identity in 262 aa overlap). Also highly similar (or just similar) to others e.g. Q9ADE8|PPGK from Streptomyces coelicolor (246 aa), FASTA scores: opt: 912, E(): 3e-49,(57.3% identity in 239 aa overlap); Q9AGV8|PPGK from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (277 aa), FASTA scores: opt: 890, E(): 7.5e-48, (57.75% identity in 239 aa overlap); P40184|GLK_STRCO|SC6E10.20c from Streptomyces coelicolor (317 aa), FASTA scores: opt: 233, E(): 3.2e-07, (31.3% identity in 163 aa overlap); etc.	Q7TY27	No	intermediary metabolism and respiration							IPR000600	Q7TY27	A0A1R3Y1Y1				Rv2702		Rv2702			
NC_002945.3	Mycobrowser_v4	CDS	2982077	2983483	.	+	0	Mb2732	sthA		PROBABLE SOLUBLE PYRIDINE NUCLEOTIDE TRANSHYDROGENASE STHA (STH) (NAD(P)(+) TRANSHYDROGENASE [B-SPECIFIC]) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE)	Mb2732, sthA, len: 468 aa. Equivalent to Rv2713,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable sthA,soluble pyridine nucleotide transhydrogenase (EC 1.6.1.1),highly similar to others e.g. Q983E2|MLR8366 from Rhizobium loti (Mesorhizobium loti) (481 aa), FASTA scores: opt: 1447, E(): 4.1e-78, (49.55% identity in 460 aa overlap); P27306|STHA_ECOLI|STH|UDHA|B3962 from Escherichia coli strain K12 (465 aa), FASTA scores: opt: 1267, E(): 1.7e-67, (43.05% identity in 462 aa overlap); O05139|STHA_PSEFL|STH from Pseudomonas fluorescens (463 aa), FASTA scores: opt: 1257, E(): 6.6e-67, (43.8% identity in 461 aa overlap); etc. Also highly similar to CAC46308|SMC00300 PUTATIVE OXIDOREDUCTASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (467 aa),FASTA scores: opt: 1466, E(): 3e-79, (49.55% identity in 462 aa overlap). Shows some similarity to MTCY359.04, E(): 3.1e-08; MTCY210.05, E(): 3.4e-08. Contains ATP/GTP-binding site motif A (P-loop; PS00017). BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD (BY SIMILARITY).	X2BM22,P66007	No	intermediary metabolism and respiration								X2BM22,P66007	P66007				Rv2713		Rv2713			
NC_002945.3	Mycobrowser_v4	CDS	2974471	2976057	.	+	0	Mb2722	sigA		RNA POLYMERASE SIGMA FACTOR SIGA (SIGMA-A)	Mb2722, sigA, len: 528 aa. Equivalent to Rv2703,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 528 aa overlap). sigA (formerly named mysA, and also known as rpoV or rpoD), RNA polymerase sigma factor (see citations below), equivalent (but shorter 55 aa) to Q9S5K3|RPOT (alias Q59532) RNA POLYMERASE SIGMA FACTOR from Mycobacterium leprae (576 aa), FASTA scores: opt: 2638, E(): 8.6e-115, (80.35% identity in 535 aa overlap). Also similar to others e.g. Q59552|MYSA from Mycobacterium smegmatis (466 aa), FASTA scores: opt: 2259, E(): 2.3e-97, (76.5% identity in 528 aa overlap); Q45302|SIGA from Corynebacterium glutamicum (Brevibacterium flavum) (497 aa), FASTA scores: opt: 1972,E(): 4.3e-84, (67.35% identity in 505 aa overlap); Q59813|HRDB from Streptomyces aureofaciens (525 aa), FASTA scores: opt: 1654, E(): 2.1e-69, (67.5% identity in 468 aa overlap); etc. Contains sigma-70 family signatures 1 and 2 (PS00715 and PS00716). BELONGS TO THE SIGMA-70 FACTOR FAMILY.	X2BM11,P0A603	No	information pathways								X2BM11,P0A603	P0A603				Rv2703		Rv2703			
NC_002945.3	Mycobrowser_v4	CDS	2979097	2980068	.	+	0	Mb2729	sigB		RNA POLYMERASE SIGMA FACTOR SIGB	Mb2729, sigB, len: 323 aa. Equivalent to Rv2710,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). sigB (formerly known as mysB), RNA polymerase sigma factor (see citations below), equivalent to Q59531|ML1014 RNA POLYMERASE SIGMA FACTOR from Mycobacterium leprae (319 aa), FASTA scores: opt: 1935, E(): 1.9e-109, (96.2% identity in 316 aa overlap). Also highly similar to others e.g. Q59553|MYSB from Mycobacterium smegmatis (319 aa), FASTA scores: opt: 1874, E(): 9.1e-106, (92.4% identity in 316 aa overlap); Q9ANT6|SIGB from Brevibacterium flavum (331 aa), FASTA scores: opt: 1525, E(): 9.9e-85, (78.9% identity in 303 aa overlap); Q60158|RPOV from Mycobacterium bovis (528 aa),FASTA scores: opt: 1246, E(): 9.3e-68, (62.85% identity in 315 aa overlap); etc. Contains sigma-70 factors family signatures 1 and 2 (PS00715 and PS00716). And contains possible helix-turn-helix motif at aa 282-303 (Score 1887,+5.61 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY.	Q7TY20	No	information pathways							IPR000943,IPR007624,IPR007627,IPR007630,IPR009042,IPR011991,IPR013324,IPR013325,IPR014284	Q7TY20	A0A1R3Y258				Rv2710		Rv2710			
NC_002945.3	Mycobrowser_v4	CDS	2980201	2980893	.	+	0	Mb2730	ideR		IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER	Mb2730, ideR, len: 230 aa. Equivalent to Rv2711,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). ideR (formerly known as dtxR), iron dependent repressor and activator (see citations below), equivalent to Q9CCB5|ML1013 IRON DEPENDENT REPRESSOR from Mycobacterium leprae (230 aa),FASTA scores: opt: 1365, E(): 3.8e-77, (90.0% identity in 230 aa overlap). Also highly similar to others e.g. Q50379|DTXR from Mycobacterium smegmatis (233 aa), FASTA scores: opt: 1291, E(): 1.4e-72, (86.1% identity in 230 aa overlap); Q9F7T3|IDER from Corynebacterium equii (Rhodococcus equi) (230 aa), FASTA scores: opt: 1130, E(): 1.2e-62, (74.8% identity in 230 aa overlap); P33120|DTXR_CORDI from Corynebacterium diphtheriae (226 aa), FASTA scores: opt: 803, E(): 1.6e-42, (57.85% identity in 230 aa overlap); etc. BELONGS TO THE FUR FAMILY.	X2BLC3,P0A673	No	regulatory proteins								X2BLC3,P0A673	P0A673				Rv2711		Rv2711			
NC_002945.3	Mycobrowser_v4	CDS	2987049	2987513	.	-	0	Mb2737c	nrdr		probable transcriptional regulatory protein nrdr	Mb2737c, -, len: 154 aa. Equivalent to Rv2718c,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Conserved hypothetical protein, equivalent to Q49844|ML1005|U2235A|B2235_C2_209 HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 937, E(): 1.5e-52, (92.7% identity in 151 aa overlap). Highly similar to O86848|NRDR_STRCL PUTATIVE REGULATORY PROTEIN from Streptomyces clavuligerus (172 aa), FASTA scores: opt: 750, E(): 1.1e-40, (73.65% identity in 148 aa overlap); O69980|SC4H2.25 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (182 aa), FASTA scores: opt: 725, E(): 4.6e-39, (73.1% identity in 145 aa overlap); Q9KPU0|VC2272 HYPOTHETICAL PROTEIN from Vibrio cholerae (156 aa), FASTA scores: opt: 462, E(): 1.8e-22,(47.3% identity in 148 aa overlap); etc.	X2BM29,P67314	No	regulatory proteins								X2BM29,P67314	P67314				Rv2718c		Rv2718c			
NC_002945.3	Mycobrowser_v4	CDS	2988481	2989134	.	+	0	Mb2739	lexA		REPRESSOR LEXA	Mb2739, lexA, len: 217 aa. Equivalent to Rv2720,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 217 aa overlap). LexA repressor (EC 3.4.21.88) (see citations below), equivalent to Q49848|LEXA_MYCLE|ML1003|B2235_F2_55 LEXA REPRESSOR from Mycobacterium leprae (217 aa), FASTA scores: opt: 1255,E(): 7.1e-70, (89.8% identity in 216 aa overlap). Also highly similar to others e.g. O69979|LEXA_STRCO|SC4H2.24c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 1034, E(): 2.6e-56, (70.5% identity in 217 aa overlap); O86847|LEXA_STRCL from Streptomyces clavuligerus (239 aa),FASTA scores: opt: 1021, E(): 1.6e-55, (69.1% identity in 217 aa overlap); Q9KAD3|LEXA_BACHD from Bacillus halodurans (207 aa), FASTA scores: opt: 645, E(): 1.5e-32,(47.9% identity in 213 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY S24; ALSO KNOWN AS THE UMUD/LEXA FAMILY.	X2BLP2,Q7TY15	No	regulatory proteins								X2BLP2,Q7TY15	Q7TY15				Rv2720		Rv2720			
NC_002945.3	Mycobrowser_v4	CDS	3015836	3016360	.	+	0	Mb2768	arga		probable l-glutamate alpha-n-acetyltranferase arga (alpha-n-acetylglutamate synthase)	Mb2768, -, len: 174 aa. Equivalent to Rv2747, len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Possible transferase (EC 2.-.-.-), equivalent to O05559|ML0978|MLCB33.08 PUTATIVE ACETYLTRANSFERASE from Mycobacterium leprae (180 aa), FASTA scores: opt: 997, E(): 1.2e-57, (86.8% identity in 174 aa overlap). Also similar to various transferases e.g. Q9X8N2|SCE94.27c PUTATIVE ACETYLTRANSFERASE from Streptomyces coelicolor (169 aa), FASTA scores: opt: 656,E(): 1.3e-35, (60.35% identity in 164 aa overlap); C-terminus of Q9K3D6|ARGH(A) ARGININOSUCCINASE AND N-ACETYLGLUTAMATE SYNTHASE from Moritella sp. 2693 (629 aa), FASTA scores: opt: 243, E(): 2e-08, (31.95% identity in 144 aa overlap); C-terminus of Q9JW21|ARGA OR NMA0580 PUTATIVE ACETYLGLUTAMATE SYNTHASE from Neisseria meningitidis serogroup A (436 aa), FASTA scores: opt: 201,E(): 7.8e-06, (32.75% identity in 119 aa overlap); etc. Also similar to hypothetical proteins e.g. O67372|AQ_1359 HYPOTHETICAL 21.1 KDA PROTEIN from Aquifex aeolicus (181 aa), FASTA scores: opt: 348, E(): 1.2e-15, (42.35% identity in 137 aa overlap).	Q7TXZ2	No	intermediary metabolism and respiration							IPR000182,IPR016181	Q7TXZ2	A0A1R3Y2W2				Rv2747		Rv2747			
NC_002945.3	Mycobrowser_v4	CDS	3023767	3024519	.	-	0	Mb2775c	thyx		probable thymidylate synthase thyx (ts) (tsase)	Mb2775c, -, len: 250 aa. Equivalent to Rv2754c,len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 250 aa overlap). Conserved hypothetical ala-rich protein, equivalent to Q9CBW3|YF14_MYCLE|ML1514 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium leprae (254 aa), FASTA scores: opt: 1351, E(): 1e-84, (81.5% identity in 254 aa overlap). Also highly similar to 40111|YDAP_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (250 aa), FASTA scores: opt: 1071, E(): 1.2e-65, (62.85% identity in 245 aa overlap); Q05259|VG48_BPML5 GENE 48 PROTEIN (GP48) from Mycobacteriophage L5 (243 aa),, FASTA scores: opt: 610,E(): 3.2e-34, (49.55% identity in 220 aa overlap); O64238|VG48_BPMD2 GENE 48 PROTEIN (GP48) from Mycobacteriophage D29 (235 aa), FASTA scores: opt: 593,E(): 4.5e-33, (46.95% identity in 245 aa overlap); etc. BELONGS TO THE THY1 FAMILY.	X2BLF4,P66931	No	intermediary metabolism and respiration								X2BLF4,P66931	P66931				Rv2754c		Rv2754c			
NC_002945.3	Mycobrowser_v4	CDS	2996461	2997405	.	-	0	Mb2746c	miaA		PROBABLE TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE MIAA (IPP TRANSFERASE) (ISOPENTENYL-DIPHOSPHATE:TRNA ISOPENTENYLTRANSFERASE) (IPTASE) (IPPT)	Mb2746c, miaA, len: 314 aa. Equivalent to Rv2727c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable miaA, tRNA delta(2)-isopentenylpyrophosphate transferase (EC 2.5.1.8), equivalent to P46811|MIAA_MYCLE|ML0995|B2235_C3_232 TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE from Mycobacterium leprae (311 aa), FASTA scores: opt: 1679,E(): 3.2e-89, (81.85% identity in 314 aa overlap). Also highly similar to many e.g. O69967|MIAA_STRCO|SC4H2.12 from Streptomyces coelicolor (312 aa), FASTA scores: opt: 1006, E(): 1.2e-50, (55.5% identity in 301 aa overlap); O31795|MIAA_BACSU from Bacillus subtilis (314 aa), FASTA scores: opt: 671, E(): 1.9e-31, (38.55% identity in 293 aa overlap);P16384|MIAA_ECOLI|TRPX|B4171 from Escherichia coli strain K12 and Shigella flexneri (316 aa), FASTA scores: opt: 565, E(): 2.3e-25, (35.2% identity in 307 aa overlap);etc. Contains PS00017 ATP/GTP-binding site motif A (P -loop). BELONGS TO THE IPP TRANSFERASE FAMILY.	X2BLQ5,P65353	No									X2BLQ5,P65353	P65353									
NC_002945.3	Mycobrowser_v4	CDS	2992767	2993927	.	-	0	Mb2743c	fadE20		PROBABLE ACYL-CoA DEHYDROGENASE FADE20	Mb2743c, fadE20, len: 386 aa. Equivalent to Rv2724c, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 386 aa overlap). Probable fadE20, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. Q9X7Y2|SC6A5.36 from Streptomyces coelicolor (382 aa), FASTA scores: opt: 1583, E(): 6.9e-94, (62.7% identity in 378 aa overlap); Q9HVY0|PA4435 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 1468, E(): 1.6e-86, (57.65% identity in 380 aa overlap); Q9ABZ1|CC0079 from Caulobacter crescentus (391 aa), FASTA scores: opt: 1298, E(): 1.2e-75, (51.9% identity in 391 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis proteins e.g. O06164|FADE19|Rv2500c|MTCY07A7.06c ACYL-CoA DEHYDROGENASE (394 aa) (34.3% identity in 382 aa overlap). Contains acyl-CoA dehydrogenases signature 2 (PS00073). BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY.	Q7TY12	No	lipid metabolism							IPR006089,IPR006091,IPR009075,IPR009100,IPR013786	Q7TY12	A0A1R3Y203				Rv2724c		Rv2724c			
NC_002945.3	Mycobrowser_v4	CDS	2994063	2995550	.	-	0	Mb2744c	hflX		PROBABLE GTP-BINDING PROTEIN HFLX	Mb2744c, hflX, len: 495 aa. Equivalent to Rv2725c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 495 aa overlap). Probable hflX (hfl for high frequency of lysogenization), GTP-binding protein (EC 3.1.5.-),equivalent to Q9CCC0|ML0997 (alias Q49843|HFLX but longer) POSSIBLE ATP/GTP-BINDING PROTEIN from Mycobacterium leprae (488 aa), FASTA scores: opt: 2562, E(): 1.1e-133, (84.55% identity in 485 aa overlap). Also highly similar to many e.g. Q9XCC1 from Streptomyces fradiae (425 aa), FASTA scores: opt: 1280, E(): 3.2e-63,(57.7% identity in 423 aa overlap); P73965|HFLX|SLR1521 from Synechocystis sp. strain PCC 6803 (534 aa), FASTA scores: opt: 1028, E(): 2.8e-49, (44.7% identity in 414 aa overlap); P25519|HFLX_ECOLI|B4173 from Escherichia coli strain K12 (426 aa), FASTA scores: opt: 916, E(): 3.4e-43,(40.1% identity in 414 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TY11	No								IPR006073,IPR016496,IPR025121,IPR027417	Q7TY11	A0A1R3Y218									
NC_002945.3	Mycobrowser_v4	CDS	2995567	2996436	.	-	0	Mb2745c	dapF		PROBABLE DIAMINOPIMELATE EPIMERASE DAPF (DAP EPIMERASE)	Mb2745c, dapF, len: 289 aa. Equivalent to Rv2726c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable dapF,diaminopimelate epimerase (EC 5.1.1.7), equivalent to P46814|DAPF_MYCLE|ML0996|B2235_C3_233 DIAMINOPIMELATE EPIMERASE from Mycobacterium leprae (296 aa), FASTA scores: opt: 1488, E(): 2.1e-83, (76.05% identity in 292 aa overlap). Also highly similar to O69969|DAPF_STRCO|SC4H2.14 from Streptomyces coelicolor (289 aa), FASTA scores: opt: 439, E(): 1.4e-19, (45.6% identity in 296 aa overlap); and similar to many e.g. O29511|DAPF_ARCFU|AF0747 from Archaeoglobus fulgidus (280 aa), FASTA scores: opt: 310, E(): 9.7e-12, (33.8% identity in 296 aa overlap); Q51564|DAPF_PSEAE|PA5278 from Pseudomonas aeruginosa (276 aa), FASTA scores: opt: 272,E(): 2e-09, (30.15% identity in 292 aa overlap); P08885|DAPF_ECOLI|B3809 from Escherichia coli strain K12 (274 aa), FASTA scores: opt: 266, E(): 4.5e-09, (30.4% identity in 296 aa overlap); etc. BELONGS TO THE DIAMINOPIMELATE EPIMERASE FAMILY.	X2BLD2,P63898	No									X2BLD2,P63898	P63898									
NC_002945.3	Mycobrowser_v4	CDS	3024763	3025038	.	-	0	Mb2776c	hsdS'		possible type i restriction/modification system specificity determinant (fragment) hsds.1 (s protein)	Mb2776c, hsdS', len: 91 aa. Equivalent to Rv2755c,len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Possible hsdS',fragment of type I restriction/modification system specificity determinant (S protein), similar to the N-terminus of other hsdS proteins e.g. O34140|HSDS from Klebsiella pneumoniae (439 aa), FASTA scores: opt: 303,E(): 2.1e-13, (46.65% identity in 90 aa overlap); P72419|STY|SBLI from Salmonella typhimurium (434 aa),FASTA scores: opt: 278, E(): 1.1e-11, (47.65% identity in 86 aa overlap); and Q9P9X9|XF2741 from Xylella fastidiosa (412 aa), FASTA scores: opt: 144, E(): 0.015, (31.7% identity in 82 aa overlap). Also some similarity with O33303|Rv2761c|MTV002.26c|HSDS POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM SPECIFICITY DETERMINANT from Mycobacterium tuberculosis (364 aa), FASTA scores: opt: 145, E(): 0.012, (29.9% identity in 87 aa overlap).	Q7TXY6	No									Q7TXY6	A0A1R3Y254									
NC_002945.3	Mycobrowser_v4	CDS	3140421	3141083	.	+	0	Mb2898	mpt83		cell surface lipoprotein mpt83 (lipoprotein p23)	Mb2898, mpb83, len: 220 aa. Equivalent to Rv2873,len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 220 aa overlap). mpt83 (alternate gene name: mpb83), cell surface lipoprotein (see citations below). Also similar to upstream ORF Q50769|MP70_MYCTU|MPT70|MPB70|Rv2875|MT2943|MTCY274.06 which is also known as MAJOR SECRETED IMMUNOGENIC PROTEIN MPT70 PRECURSOR from Mycobacterium tuberculosis (193 aa),FASTA scores: opt: 806, E(): 2.7e-38, (70.25% identity in 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FAMILY. ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR.	X2BM94,P0CAX7	No									X2BM94,P0CAX7	P0CAX7									
NC_002945.3	Mycobrowser_v4	CDS	3005198	3005722	.	-	0	Mb2755c	recX		REGULATORY PROTEIN RECX	Mb2755c, recX, len: 174 aa. Equivalent to Rv2736c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 174 aa overlap). Probable recX,regulatory protein (see citation below), equivalent to P37859|RECX_MYCLE|ML0988|U2235B REGULATORY PROTEIN RECX from Mycobacterium leprae (171 aa), FASTA scores: opt: 848, E(): 2e-46, (77.0% identity in 174 aa overlap); and CAA67596|RECX|P94965|RECX_MYCSM REGULATORY PROTEIN RECX from Mycobacterium smegmatis (188 aa), FASTA scores: opt: 679, E(): 8.8e-36, (66.45% identity in 164 aa overlap). Also similar (or highly similar to) others e.g. O50488|RECX_STRCO|SC4H8.09 from Streptomyces coelicolor (188 aa), FASTA scores: opt: 371, E(): 1.9e-16, (42.7% identity in 164 aa overlap); Q9LCZ3|RECX from Xanthomonas campestris pv. citri (162 aa), FASTA scores: opt: 189,E(): 4.4e-05, (32.45% identity in 151 aa overlap); P37860|RECX_PSEAE|PA3616 from Pseudomonas aeruginosa (153 aa), FASTA scores: opt: 159, E(): 0.0032, (30.65% identity in 137 aa overlap); etc. BELONGS TO THE RECX FAMILY.	X2BLD9,P0A5U9	No									X2BLD9,P0A5U9	P0A5U9									
NC_002945.3	Mycobrowser_v4	CDS	3009869	3010318	.	+	0	Mb2760	ephg		epoxide hydrolase	Mb2760, -, len: 149 aa. Equivalent to Rv2740, len: 149 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 149 aa overlap). Conserved hypothetical protein, equivalent, but shorter 17 aa, to Q9CCC2|ML0984 (alias Q49850 but longer) HYPOTHETICAL PROTEIN from Mycobacterium leprae (164 aa), FASTA scores: opt: 481, E(): 9.7e-26, (52.0% identity in 150 aa overlap).	Q7TY00	No	virulence, detoxification, adaptation							IPR013100	Q7TY00	A0A1R3Y2H1				Rv2740		Rv2740			
NC_002945.3	Mycobrowser_v4	CDS	3010528	3012042	.	+	0	Mb2761	PE_PGRS47		pe-pgrs family protein pe_pgrs47	Mb2761, PE_PGRS47, len: 504 aa. Equivalent to Rv2741, len: 525 aa, from Mycobacterium tuberculosis strain H37Rv, (94.37% identity in 515 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. Q10637|YD25_MYCTU|Rv1325c|MT1367|MTCY130.10c HYPOTHETICAL PE-PGRS FAMILY PROTEIN (603 aa), FASTA scores: opt: 1936, E(): 1.1e-71, (56.95% identity in 611 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a diferent 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv (504 aa versus 525 aa). NO PE motif.	Q7TXZ9	No								IPR000084	Q7TXZ9	A0A1R3Y222									
NC_002945.3	Mycobrowser_v4	CDS	3013825	3014637	.	-	0	Mb2765c	35kd_ag		CONSERVED 35 KDA ALANINE RICH PROTEIN	Mb2765c, 35kd_ag, len: 270 aa. Equivalent to Rv2744c, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 270 aa overlap). 35kd_ag,conserved ala-rich protein 35-kd antigen (see citation below). N-terminal part is equivalent to Q49840|MLCB33.06c|B2235_C2_187 HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FASTA scores: opt: 789,E(): 3.4e-35, (85.05% identity in 147 aa overlap); and C-terminal part equivalent to Q49845|MLCB33.05c|B2235_C3_214 HYPOTHETICAL PROTEIN from Mycobacterium leprae (114 aa), FASTA scores: opt: 465,E(): 3.6e-18, (65.8% identity in 114 aa overlap); note that these two proteins from Mycobacterium leprae are adjacent. Shows some similarity with Q55707||Y617_SYNY3|SLL0617 HYPOTHETICAL 28.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (267 aa), FASTA scores: opt: 155, E(): 0.19, (23.4% identity in 252 aa overlap); and C-terminus of Q9L4N1|EMM M PROTEIN from Streptococcus equisimilis (592 aa), FASTA scores: opt: 165, E(): 0.11, (23.45% identity in 260 aa overlap). C-terminus also similar to AAK45945|MT1676 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (85 aa), FASTA scores: opt: 159, E(): 0.047, (50.9% identity in 55 aa overlap).	Q7TXZ5	No								IPR007157	Q7TXZ5	A0A1R3Y211									
NC_002945.3	Mycobrowser_v4	CDS	3014767	3015105	.	-	0	Mb2766c	clgr		transcriptional regulatory protein clgr	Mb2766c, -, len: 112 aa. Equivalent to Rv2745c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Possible transcriptional regulatory protein, highly similar to O86815|SC7C7.10 HYPOTHETICAL 13.6 KDA PROTEIN from Streptomyces coelicolor (126 aa), FASTA scores: opt: 300,E(): 2.4e-13, (60.45% identity in 86 aa overlap); and highly similar to other transcriptional regulators e.g. Q9X7S1|SC5H1.13c POSSIBLE DNA-BINDING PROTEIN from Streptomyces coelicolor (157 aa), FASTA scores: opt: 254,E(): 3.3e-10, (50.0% identity in 94 aa overlap) (N-terminus longer); Q9F885|POPR TRANSCRIPTIONAL REGULATOR from Streptomyces lividans (148 aa), FASTA scores: opt: 248, E(): 7.8e-10, (53.6% identity in 97 aa overlap) (N-terminus longer); Q9FCH1|2SCD46.12 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (141 aa), FASTA scores: opt: 162, E(): 0.00038, (33.0% identity in 106 aa overlap); etc.	Q7TXZ4	No	regulatory proteins							IPR001387,IPR010982	Q7TXZ4	A0A1R3Y247				Rv2745c		Rv2745c			
NC_002945.3	Mycobrowser_v4	CDS	3015176	3015805	.	-	0	Mb2767c	pgsA3		PROBABLE PGP SYNTHASE PGSA3 (CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE)	Mb2767c, pgsA3, len: 209 aa. Equivalent to Rv2746c,len: 209 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 209 aa overlap). Probable pgsA3, PGP synthase (EC 2.7.8.5) (see citation below), transmembrane protein, equivalent, but longer 19 aa, to Q49839|O08087|PGSA|ML0979 PGSA from Mycobacterium leprae (193 aa), FASTA scores: opt: 925, E(): 3.7e-53, (77.15% identity in 188 aa overlap). Also highly similar to O86813|PGSA PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE from Streptomyces coelicolor (263 aa), FASTA scores: opt: 692,E(): 6.6e-38, (57.85% identity in 185 aa overlap) (has its N-terminus longer); and similar to others (generally with N-terminus shorter) e.g. Q99XI0|PGSA|SPY2196 PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE from Streptococcus pyogenes (180 aa), FASTA scores: opt: 368, E(): 5.4e-17,(39.9% identity in 168 aa overlap); Q9ZE96|PGSA_RICPR|PGSA|RP049 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Rickettsia prowazekii (181 aa), FASTA scores: opt: 343, E(): 2.3e-15, (40.1% identity in 172 aa overlap); P06978|PGSA_ECOLI|PGSA|B1912|Z3000|ECS2650 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Escherichia coli strains K12 and O157:H7 (181 aa), FASTA scores: opt: 322, E(): 5.3e-14, (34.45% identity in 180 aa overlap); etc. Also some similarity to PGSA2|Rv1822|MTCY1A11.21c PROBABLE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Mycobacterium tuberculosis (209 aa), FASTA score: (27.1% identity in 166 aa overlap). Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY.	Q7TXZ3	No								IPR000462,IPR004570	Q7TXZ3	A0A1R3Y425									
NC_002945.3	Mycobrowser_v4	CDS	3022796	3023698	.	-	0	Mb2774c	dapA		PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) (DIHYDRODIPICOLINATE SYNTHETASE)	Mb2774c, dapA, len: 300 aa. Equivalent to Rv2753c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). Probable dapA,dihydrodipicolinate synthase (EC 4.2.1.52), equivalent to Q9CBW4|DAPA_MYCLE|ML1513 DIHYDRODIPICOLINATE SYNTHASE from Mycobacterium leprae (300 aa), FASTA scores: opt: 1699,E(): 2.2e-98, (86.65% identity in 300 aa overlap). Also highly similar to many e.g. P19808|DAPA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (301 aa), FASTA scores: opt: 1089, E(): 2e-60, (58.7% identity in 288 aa overlap); O86841|DAPA_STRCO|SC9A10.08 from Streptomyces coelicolor (299 aa), FASTA scores: opt: 1044,E(): 1.3e-57, (55.75% identity in 287 aa overlap); P05640|DAPA_ECOLI (292 aa), FASTA scores: opt: 515, E(): 0, (33.8% identity in 287 aa overlap); etc. Contains PS00665 and PS00666 Dihydrodipicolinate synthetase signatures 1 and 2. BELONGS TO THE DHDPS FAMILY.	X2BLS1,P63946	No									X2BLS1,P63946	P63946									
NC_002945.3	Mycobrowser_v4	CDS	3016429	3019080	.	-	0	Mb2769c	ftsK		POSSIBLE CELL DIVISION TRANSMEMBRANE PROTEIN FTSK	Mb2769c, ftsK, len: 883 aa. Equivalent to Rv2748c,len: 883 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 883 aa overlap). Possible ftsK, cell division transmembrane protein, equivalent to O05560|ML0977|FTSK|MLCB33.09c CELL DIVISION PROTEIN from Mycobacterium leprae (886 aa), FASTA scores: opt: 3147,E(): 7.9e-175, (78.1% identity in 885 aa overlap). Also similar to other members of the spoIIIE/ftsK family e.g. O86810|SC7C7.05 FTSK HOMOLOG from Streptomyces coelicolor (929 aa), FASTA scores: opt: 2256, E(): 3.8e-123, (49.05% identity in 924 aa overlap); Q9CF25|FTSK CELL DIVISION PROTEIN FTSK from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (763 aa), FASTA scores: opt: 1438,E(): 9.1e-76, (37.7% identity in 751 aa overlap); AAK75005|Q97RE4|SP0878 SPOE FAMILY PROTEIN from Streptococcus pneumoniae (767 aa), FASTA scores: opt: 1405, E(): 7.5e-74, (48.0% identity in 477 aa overlap); P46889|FTSK_ECOLI|B0890 from Escherichia coli strain K12 (1329 aa), FASTA scores: opt: 759, E(): 0, (44.5% identity in 537 aa overlap) (similarity in C-terminal half); etc. Equivalent to AAK47139 from Mycobacterium tuberculosis strain CDC1551 (968 aa) but shorter 85 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FTSK/SPOIIIE FAMILY.	Q7TXZ1	No								IPR002543,IPR003593,IPR018541,IPR027417	Q7TXZ1	A0A1R3Y287									
NC_002945.3	Mycobrowser_v4	CDS	3025035	3026657	.	-	0	Mb2777c	hsdM		POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM DNA METHYLASE HSDM (M PROTEIN) (DNA METHYLTRANSFERASE)	Mb2777c, hsdM, len: 540 aa. Equivalent to Rv2756c,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 540 aa overlap). Possible hsdM, type I restriction/modification system DNA methylase (M protein) (EC 2.1.1.-), highly similar to others e.g. Q9P9X8|XF2742 from Xylella fastidiosa (519 aa), FASTA scores: opt: 1613,E(): 1.9e-96, (52.3% identity in 543 aa overlap); O34139|HSDM from Klebsiella pneumoniae (539 aa), FASTA scores: opt: 1267, E(): 4.4e-74, (45.9% identity in 549 aa overlap); P72418|STY|SBLI|HSDM from Salmonella typhimurium (539 aa), FASTA scores: opt: 1263, E(): 8e-74, (45.7% identity in 549 aa overlap); etc. Possible alternative start site (GTG) overlapping with termination codon of previous ORF 90 bp upstream. Note that the corresponding endonuclease (M protein) does not appear to be present in Mycobacterium tuberculosis.	Q7TXY5	No								IPR002296,IPR003356,IPR022749	Q7TXY5	A0A1R3Y434									
NC_002945.3	Mycobrowser_v4	CDS	3026744	3027160	.	-	0	Mb2778c	vapc21		possible toxin vapc21	Mb2778c, -, len: 138 aa. Equivalent to Rv2757c,len: 138 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 138 aa overlap). Conserved hypothetical protein, similar to several other M. tuberculosis hypothetical proteins e.g. P96411|Rv0229c| MTCY08D5.24c (226 aa), FASTA scores: opt: 354, E(): 4.6e-18, (45.25% identity in 137 aa overlap) (N-terminus longer 89 aa); P95007|RV2546|MTCY159.10c (137 aa), FASTA scores: opt: 265, E(): 7.5e-12, (38.5% identity in 135 aa overlap); O07228|Rv0301|MTCY63.06 (141 aa), FASTA scores: opt: 259, E(): 2.1e-11, (42.4% identity in 132 aa overlap); etc.	Q7TXY4	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TXY4	A0A1R3Y2X2				Rv2757c		Rv2757c			
NC_002945.3	Mycobrowser_v4	CDS	3027157	3027423	.	-	0	Mb2779c	vapb21		possible antitoxin vapb21	Mb2779c, -, len: 88 aa. Equivalent to Rv2758c, len: 88 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 88 aa overlap). Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. P95008|Rv2545 (92 aa), FASTA scores: opt: 151, E(): 0.00028, (66.65% identity in 45 aa overlap); Q10771|YF60_MYCTU|RV1560|MT1611|MTCY48.05c (72 aa), FASTA scores: opt: 106, E(): 0.52, (39.15% identity in 46 aa overlap); O06565|Rv1113|MTCY22G8.02 (65 aa), FASTA scores: opt: 97, E(): 2.2, (33.35% identity in 69 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.	Q7TXY3	No	virulence, detoxification, adaptation							IPR019239	Q7TXY3	A0A1R3Y296				Rv2758c		Rv2758c			
NC_002945.3	Mycobrowser_v4	CDS	3027449	3027844	.	-	0	Mb2780c	vapc42		possible toxin vapc42. contains pin domain.	Mb2780c, -, len: 131 aa. Equivalent to Rv2759c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Conserved hypothetical protein, highly similar to three M. tuberculosis hypothetical proteins O07769|Y609_MYCTU|Rv0609|MT0638|MTCY19H5.13c (133 aa),FASTA scores: opt: 364, E(): 5.1e-18, (49.6% identity in 131 aa overlap); P96914|Y624_MYCTU|Rv0624|MT0652|MTCY20H10.05 (131 aa),FASTA scores: opt: 324, E(): 2.9e-15, (42.85% identity in 126 aa overlap); and Q10874|YJ82_MYCTU|Rv1982c|MT2034|MTCY39.37 (139 aa), FASTA scores: opt: 271, E(): 1.4e-11, (38.6% identity in 127 aa overlap). Also similar to other hypothetical proteins from other bacteria e.g. CAC45376|SMC00900 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (128 aa), FASTA scores: opt: 286,E(): 1.2e-12, (39.55% identity in 129 aa overlap); Q981I7|MLL9357 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (131 aa), FASTA scores: opt: 257,E(): 1.2e-10, (36.35% identity in 132 aa overlap); Q9AAG1|CC0639 HYPOTHETICAL PROTEIN from Caulobacter crescentus (131 aa), FASTA scores: opt: 217, E(): 6.9e-08,(33.35% identity in 132 aa overlap); etc.	X2BLF7,P67243	No	virulence, detoxification, adaptation								X2BLF7,P67243	P67243				Rv2759c		Rv2759c			
NC_002945.3	Mycobrowser_v4	CDS	3027841	3028110	.	-	0	Mb2781c	vapb42		possible antitoxin vapb42	Mb2781c, -, len: 89 aa. Equivalent to Rv2760c, len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Conserved hypothetical protein, showing some similarity with two hypothetical proteins from Mycobacterium tuberculosis O07770|Rv0608|MTCY19H5.14c (81 aa), FASTA scores: opt: 128, E(): 0.057, (37.5% identity in 88 aa overlap); and P96913|Rv0623|MTCY20H10.04 (84 aa), FASTA scores: opt: 99,E(): 5.5, (37.1% identity in 89 aa overlap). Also showing some similarity with CAC45377|SMC00899 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (84 aa), FASTA scores: opt: 116,E(): 0.38, (36.25% identity in 91 aa overlap).	Q7TXY2	No	virulence, detoxification, adaptation							IPR011660	Q7TXY2	A0A1R3Y243				Rv2760c		Rv2760c			
NC_002945.3	Mycobrowser_v4	CDS	3028120	3029214	.	-	0	Mb2782c	hsdS		POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM SPECIFICITY DETERMINANT HSDS (S PROTEIN)	Mb2782c, hsdS, len: 364 aa. Equivalent to Rv2761c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 364 aa overlap). Possible hsdS, type I restriction/modification system specificity determinant (S protein), similar in part to other hsdS protein (S PROTEINS) e.g. Q9P9X9|XF2741 from Xylella fastidiosa (412 aa), FASTA scores: opt: 252, E(): 7.4e-09, (24.95% identity in 401 aa overlap); N-terminus of Q9RC12 TYPE I S-SUBUNIT from Lactobacillus delbrueckii (subsp. lactis) (389 aa), FASTA scores: opt: 232, E(): 1.4e-07, (28.1% identity in 185 aa overlap); N-terminus of P72419|STY|SBLI from Salmonella typhimurium (434 aa), FASTA scores: opt: 221, E(): 8e-07, (28.45% identity in 130 aa overlap); C-terminus of P17222|PRRB_ECOLI from Escherichia coli strain CTR5X (401 aa), FASTA scores: opt: 197, E(): 2.8e-05, (27.05% identity in 148 aa overlap); etc. SEEMS TO BELONG TO TYPE-I RESTRICTION SYSTEM S METHYLASE FAMILY.	Q7TXY1	No								IPR000055	Q7TXY1	A0A1R3Y232									
NC_002945.3	Mycobrowser_v4	CDS	3029704	3030183	.	-	0	Mb2785c	dfrA		dihydrofolate reductase dfra (dhfr) (tetrahydrofolate dehydrogenase)	Mb2785c, dfrA, len: 159 aa. Equivalent to Rv2763c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable dfrA (alternate gene name: folA), dihydrofolate reductase (EC 1.5.1.3), equivalent to O30463|FOLA DIHYDROFOLATE REDUCTASE from Mycobacterium avium (see citation below) (181 aa), FASTA scores: opt: 802, E(): 4.5e-48, (70.2% identity in 161 aa overlap); and Q9CBW1|FOLA|ML1518 DIHYDROFOLATE REDUCTASE from Mycobacterium leprae (165 aa), FASTA scores: opt: 782, E(): 1e-46, (70.55% identity in 163 aa overlap). Also highly similar to many e.g. Q9K168|DYR_NEIMB|FOLA|NMB0308 from Neisseria meningitidis (serogroup B) (162 aa), FASTA scores: opt: 469, E(): 3.8e-25, (46.65% identity in 163 aa overlap); P12833|DYR3_SALTY|DHFRIII from Salmonella typhimurium (162 aa), FASTA scores: opt: 367, E(): 4e-18, (45.4% identity in 141 aa overlap); Q59408|DYRC_ECOLI|DHFRXIII from Escherichia coli strain RA33.2 (165 aa), FASTA scores: opt: 313, E(): 2.2e-14, (41.9% identity in 136 aa overlap); etc. Contains PS00075 Dihydrofolate reductase signature. BELONGS TO THE DIHYDROFOLATE REDUCTASE FAMILY.	X2BLG2,P0A547	No									X2BLG2,P0A547	P0A547									
NC_002945.3	Mycobrowser_v4	CDS	3030254	3031045	.	-	0	Mb2786c	thyA		PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	Mb2786c, thyA, len: 263 aa. Equivalent to Rv2764c,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 263 aa overlap). Probable thyA,thymidylate synthase (EC 2.1.1.45), equivalent to Q9CBW0|TYSY_MYCLE|THYA|ML1519 THYMIDYLATE SYNTHASE from Mycobacterium leprae (266 aa), FASTA scores: opt: 1602,E(): 5.9e-102, (85.5% identity in 262 aa overlap). Also highly similar to many e.g. P00470|TYSY_ECOLI|B2827|Z4144|ECS3684|BAB37107|AAG57938 from Escherichia coli strains K12 and O157:H7 (264 aa),FASTA scores: opt: 1309, E(): 5.9e-82, (66.65% identity in 261 aa overlap); P48464|TYSY_SHIFL|THYA from Shigella flexneri (264 aa), FASTA scores: opt: 1303, E(): 1.5e-81,(65.9% identity in 261 aa overlap); P54081|TYSB_BACAM|THYB|THYBA from Bacillus amyloliquefaciens (264 aa), FASTA scores: opt: 1235, E(): 6.7e-77, (66.65% identity in 261 aa overlap); etc. Contains PS00091 Thymidylate synthase active site. BELONGS TO THE THYMIDYLATE SYNTHASE FAMILY.	X2BLW1,P67045	No									X2BLW1,P67045	P67045									
NC_002945.3	Mycobrowser_v4	CDS	3033468	3034652	.	-	0	Mb2790c	PPE43		ppe family protein ppe43	Mb2790c, PPE43, len: 394 aa. Equivalent to Rv2768c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 394 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. upstream ORF O33312|Rv2770c|MTV002.35c (402 aa),FASTA scores: opt: 1135, E(): 6.1e-51, (62.15% identity in 391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from M. tuberculosis (391 aa), FASTA scores: opt: 1721, E(): 6.8e-81, (70.35% identity in 398 aa overlap). Equivalent to AAK47157 from Mycobacterium tuberculosis strain CDC1551 (462 aa) but shorter 68 aa.	Q7TXX5	No								IPR000030,IPR022171	Q7TXX5	A0A1R3Y2K0									
NC_002945.3	Mycobrowser_v4	CDS	3035883	3037031	.	-	0	Mb2792c	PPE44		ppe family protein ppe44	Mb2792c, PPE44, len: 382 aa. Equivalent to Rv2770c,len: 382 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 382 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. downstream ORF O33310|Rv2768c|MTV002.33c from M. tuberculosis (394 aa), FASTA scores: opt: 1135, E(): 2.2e-53, (62.15% identity in 391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 1010, E(): 1e-46, (55.95% identity in 395 aa overlap). Equivalent to AAK47159 from M. tuberculosis strain CDC1551 (402 aa) but shorter 20 aa. Start changed since first submission (-20 aa).	Q7TXX3	No								IPR000030,IPR022171	Q7TXX3	A0A1R3Y245									
NC_002945.3	Mycobrowser_v4	CDS	3038178	3038915	.	-	0	Mb2795c	dapB		DIHYDRODIPICOLINATE REDUCTASE DAPB (DHPR)	Mb2795c, dapB, len: 245 aa. Equivalent to Rv2773c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 245 aa overlap). dapB,dihydrodipicolinate reductase (EC 1.3.1.26) (see first citation below), highly similar to many e.g. P40110|DAPB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (248 aa), FASTA scores: opt: 1030,E(): 1.8e-58, (65.45% identity in 246 aa overlap); O86836|DAPB_STRCO|SC9A10.03 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 997, E(): 2.3e-56, (61.15% identity in 247 aa overlap); P42976|DAPB_BACSU from Bacillus subtilis (267 aa), FASTA scores: opt: 608, E(): 1.7e-31, (45.95% identity in 209 aa overlap); P46829|DAPB_MYCBO from Mycobacterium bovis (see second citation below) (271 aa), FASTA scores: opt: 505, E(): 6.3e-25, (36.2% identity in 246 aa overlap); etc. BELONGS TO THE DIHYDRODIPICOLINATE REDUCTASE FAMILY.	X2BLH0,Q7TXX0	No									X2BLH0,Q7TXX0	Q7TXX0									
NC_002945.3	Mycobrowser_v4	CDS	3043370	3043768	.	+	0	Mb2802	alda		SECRETED L-ALANINE DEHYDROGENASE ALDa [FIRST PART] (40 KDA ANTIGEN) (TB43)	Mb2802, alda, len: 132 aa. Similar to 5' end of Rv2780, len: 371 aa, from Mycobacterium tuberculosis strain H37Rv, (98.9% identity in 89 aa overlap). ald,secreted L-alanine dehydrogenase (EC 1.4.1.1) (40 kd antigen) (see first citations below); equivalent to Q9CBV6|ALD|ML1532 L-ALANINE DEHYDROGENASE from Mycobacterium leprae (371 aa), FASTA scores: opt: 2081,E(): 4e-115, (85.45% identity in 371 aa overlap). Also highly similar to others e.g. Q9S227|SCI51.13c from Streptomyces coelicolor (371 aa), FASTA scores: opt: 1575,E(): 2.3e-85, (66.05% identity in 371 aa overlap); Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372 aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans (390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2% identity in 371 aa overlap); etc. Contains PS00836 and PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 and 2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, alda and aldb.	Q7TXW3	No								IPR007886,IPR008142	Q7TXW3	A0A1R3Y257									
NC_002945.3	Mycobrowser_v4	CDS	3050028	3050297	.	-	0	Mb2808c	rpsO		30s ribosomal protein s15 rpso	Mb2808c, rpsO, len: 89 aa. Equivalent to Rv2785c,len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Probable rpsO, 30s ribosomal protein S15, equivalent to O32967|RS15_MYCLE|RPSO|ML0853|MLCB22.28c 30S RIBOSOMAL PROTEIN S15 from Mycobacterium leprae (89 aa), FASTA scores: opt: 522, E(): 7.4e-34, (92.15% identity in 89 aa overlap). Also highly similar to many e.g. O86655|RS15_STRCO|RPSO|SC3C3.22 from Streptomyces coelicolor (95 aa), FASTA scores: opt: 408, E(): 6.7e-25,(62.9% identity in 89 aa overlap); P05766|RS15_BACST|RPSO from Bacillus stearothermophilus (88 aa), FASTA scores: opt: 385, E(): 4e-23, (62.5% identity in 88 aa overlap); P21473|RS15_BACSU|RPSO from Bacillus subtilis (88 aa),FASTA scores: opt: 351, E(): 1.9e-20, (57.95% identity in 88 aa overlap); P02371|RS15_ECOLI|RPSO|SEC|B3165 from Escherichia coli strain K12 (88 aa), FASTA scores: opt: 295, E(): 4.5e-22, (52.3% identity in 88 aa overlap); etc. Contains PS00362 Ribosomal protein S15 signature. BELONGS TO THE S15P FAMILY OF RIBOSOMAL PROTEINS.	X2BLL1,P66430	No									X2BLL1,P66430	P66430									
NC_002945.3	Mycobrowser_v4	CDS	3043765	3044484	.	+	0	Mb2803	aldb		SECRETED L-ALANINE DEHYDROGENASE ALDb [SECOND PART] (40 KDA ANTIGEN) (TB43)	Mb2803, aldb, len: 239 aa. Equivalent to 3' end of Rv2780, len: 371 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 239 aa overlap). ald,secreted L-alanine dehydrogenase (EC 1.4.1.1) (40 kd antigen) (see first citations below); equivalent to Q9CBV6|ALD|ML1532 L-ALANINE DEHYDROGENASE from Mycobacterium leprae (371 aa), FASTA scores: opt: 2081,E(): 4e-115, (85.45% identity in 371 aa overlap). Also highly similar to others e.g. Q9S227|SCI51.13c from Streptomyces coelicolor (371 aa), FASTA scores: opt: 1575,E(): 2.3e-85, (66.05% identity in 371 aa overlap); Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372 aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans (390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2% identity in 371 aa overlap); etc. Contains PS00836 and PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 and 2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, alda and aldb.	Q7TXW2	No								IPR007698,IPR008141,IPR008143,IPR016040	Q7TXW2	A0A1R3Y259									
NC_002945.3	Mycobrowser_v4	CDS	3050454	3051449	.	-	0	Mb2809c	ribF		probable bifunctional fad synthetase/riboflavin biosynthesis protein ribf: riboflavin kinase (flavokinase) + fmn adenylyltransferase (fad pyrophosphorylase) (fad synthetase)(fad diphosphorylase) (flavin adenine dinucleotide synthetase)	Mb2809c, ribF, len: 331 aa. Equivalent to Rv2786c,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 331 aa overlap). Probable ribF, FAD synthetase/riboflavin biosynthesis protein, bifunctional enzyme (EC 2.7.1.26; 2.7.7.2), equivalent to O32968|RIBF|ML0852 RIBOFLAVIN KINASE from Mycobacterium leprae (331 aa), FASTA scores: opt: 1923, E(): 2.3e-115,(87.45% identity in 327 aa overlap). Also highly similar to many e.g. Q59263|RIBF_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (338 aa), FASTA scores: opt: 899, E(): 5.7e-50, (45.8% identity in 321 aa overlap); Q9Z530|SC9F2.05c from Streptomyces coelicolor (318 aa), FASTA scores: opt: 862, E(): 1.3e-47, (52.45% identity in 324 aa overlap); P08391|RIBF_ECOLI|B0025|Z0029ECS0028 from Escherichia coli strains K12 and O157:H7 (313 aa), FASTA scores: opt: 517, E(): 1.3e-25, (36.05% identity in 305 aa overlap); etc.	Q7TXV8	No								IPR002606,IPR014729,IPR015864,IPR015865,IPR023465,IPR023468	Q7TXV8	A0A1R3Y2C3									
NC_002945.3	Mycobrowser_v4	CDS	3045594	3046910	.	-	0	Mb2805c	pepR		PROBABLE ZINC PROTEASE PEPR	Mb2805c, pepR, len: 438 aa. Equivalent to Rv2782c,len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 438 aa overlap). Probable pepR,protease/peptidase (EC 3.4.99.-), equivalent to O32965|YR82_MYCLE|ML0855|MLCB22.26c HYPOTHETICAL ZINC PROTEASE from Mycobacterium leprae (445 aa), FASTA scores: opt: 2346, E(): 4.3e-146, (84.3% identity in 421 aa overlap). Also highly similar to others e.g. O86835|YA12_STRCO|SC9A10.02 from Streptomyces coelicolor (459 aa), FASTA scores: opt: 1394, E(): 1.1e-83, (51.9% identity in 416 aa overlap); Q04805|YMXG_BACSU|YMXG from Bacillus subtilis (409 aa), FASTA scores: opt: 1014, E(): 7.9e-59, (37.55% identity in 410 aa overlap); Q9KA85|BH2405 from Bacillus halodurans (413 aa), FASTA scores: opt: 967, E(): 9.6e-56, (38.6% identity in 417 aa overlap); etc. Contains PS00143 Insulinase family,zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M16, ALSO KNOWN AS THE INSULINASE FAMILY. COFACTOR: REQUIRES DIVALENT CATIONS FOR ACTIVITY. BINDS ZINC.	X2BLH9,P0A5S9	No									X2BLH9,P0A5S9	P0A5S9									
NC_002945.3	Mycobrowser_v4	CDS	3046888	3049146	.	-	0	Mb2806c	gpsI		BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (POLYNUCLEOTIDE PHOSPHORYLASE) (PNPASE)	Mb2806c, gpsI, len: 752 aa. Equivalent to Rv2783c,len: 752 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 752 aa overlap). Probable gpsI,polyribonucleotide nucleotidyltransferase (EC 2.7.7.8; 2.7.6.-), equivalent to Q9CCF8|GPSI|ML0854 (alias O32966) PUTATIVE POLYRIBONUCLEOTIDE PHOSPHORYLASE / GUANOSINE PENTAPHOSPHATE SYNTHETASE from Mycobacterium leprae (773 aa), FASTA scores: opt: 4304, E(): 0, (89.95% identity in 757 aa overlap). Also highly similar to others e.g. O86656|GPSI GUANOSINE PENTAPHOSPHATE SYNTHETASE/ POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (FRAGMENT) from Streptomyces coelicolor (716 aa), FASTA scores: opt: 3393,E(): 5.8e-192, (72.77% identity in 718 aa overlap); Q53597|GPSI GUANOSINE PENTAPHOSPHATE SYNTHETASE from Streptomyces antibioticus (740 aa), FASTA scores: opt: 3314, E(): 2.6e-187, (70.55% identity in 733 aa overlap); P72659|PNP|SLL1043 POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE from Synechocystis sp. strain PCC 6803 (718 aa), FASTA scores: opt: 1244, E(): 1.7e-65,(45.05% identity in 750 aa overlap); etc. Note that S. antibioticus guanosine pentaphosphate synthetase is a multifunctional enzyme that also acts as a polyribonucleotide nucleotidyltransferase. Start site chosen by homology from several alternatives.	X2BLY3,Q7TXW0	No									X2BLY3,Q7TXW0	Q7TXW0									
NC_002945.3	Mycobrowser_v4	CDS	3053508	3054194	.	+	0	Mb2811	sirR		PROBABLE TRANSCRIPTIONAL REPRESSOR SIRR	Mb2811, sirR, len: 228 aa. Equivalent to Rv2788,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 228 aa overlap). Probable sirR,transcriptional repressor, highly similar to others e.g. Q9RRF3|DR2539 PUTATIVE IRON DEPENDENT REPRESSOR from Deinococcus radiodurans (232 aa), FASTA scores: opt: 518,E(): 4.5e-26, (41.2% identity in 221 aa overlap); Q9HRU8|SIRR|VNG0536G from Halobacterium sp. strain NRC-1 (233 aa), FASTA scores: opt: 516, E(): 6.1e-26, (40.45% identity in 220 aa overlap); Q9KIJ2|SLOR REGULATOR SLOR from Streptococcus mutans (217 aa), FASTA scores: opt: 418, E(): 1.2e-19, (36.15% identity in 213 aa overlap); etc. Also some similarity to Q50495|IDER_MYCTU|MTCY05A6.32|IDER|DTXR|Rv2711|MT2784|MTCY 05A6.32 IRON-DEPENDENT REPRESSOR from Mycobacterium tuberculosis (230 aa), FASTA scores: opt: 266, E(): 7.1e-10, (27.6% identity in 221 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1327, +3.71 SD). COULD BELONG TO THE CRP/FNR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TXV6	No	regulatory proteins							IPR000485,IPR001367,IPR007167,IPR008988,IPR011991,IPR022687,IPR022689	Q7TXV6	A0A1R3Y267				Rv2788		Rv2788			
NC_002945.3	Mycobrowser_v4	CDS	3594472	3594741	.	-	0	Mb3288c	whiB2		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB2	Mb3288c, whiB2, len: 89 aa. Equivalent to Rv3260c,len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 89 aa overlap). Probable whiB2,WhiB-like regulatory protein (see first citation below),similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q9CCK0|WHIB2|ML0760 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (89 aa), FASTA scores: opt: 550, E(): 6.1e-31,(85.4% identity in 89 aa overlap). Also similar to others e.g. Q9S426 WHMD REGULATORY PROTEIN (see second citation below) from Mycobacterium smegmatis (129 aa), FASTA scores: opt: 488, E(): 1.4e-26, (83.55% identity in 85 aa overlap); Q06387|WHIB-STV WHIB-STV PROTEIN from Streptomyces griseocarneus (87 aa), FASTA scores: opt: 443, E(): 1.2e-23, (74.7% identity in 83 aa overlap); Q05429|WHIB|WHIB1 TRANSCRIPTION-LIKE FACTOR WHIB from Streptomyces aureofaciens (87 aa), FASTA scores: opt: 442,E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc. Equivalent to AAK47700 WhiB-related protein from Mycobacterium tuberculosis strain CDC1551 (123 aa) but shorter 34 aa. Also similar to other Mycobacterium tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71 aa overlap) and MTCY78.13c (37.4% identity in 91 aa overlap). Start chosen by homology but ORF continues to ATG upstream at 3754.	Q7TWV5	No								IPR003482	Q7TWV5	A0A1R3Y3S0									
NC_002945.3	Mycobrowser_v4	CDS	3054255	3055487	.	-	0	Mb2812c	fadE21		PROBABLE ACYL-CoA DEHYDROGENASE FADE21	Mb2812c, fadE21, len: 410 aa. Equivalent to Rv2789c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 410 aa overlap). Probable fadE21, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 689, E(): 9.3e-37,(35.75% identity in 400 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 679,E(): 4.1e-36, (37.3% identity in 405 aa overlap); Q06319|ACDS_MEGEL from Megasphaera elsdenii (383 aa),FASTA scores: opt: 650, E(): 3e-34, (37.7% identity in 334 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 1 (PS00072). BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TXV5	No	lipid metabolism							IPR006089,IPR006091,IPR009075,IPR009100,IPR013786	Q7TXV5	A0A1R3Y270				Rv2789c		Rv2789c			
NC_002945.3	Mycobrowser_v4	CDS	3055513	3056718	.	-	0	Mb2813c	ltp1		PROBABLE LIPID-TRANSFER PROTEIN LTP1	Mb2813c, ltp1, len: 401 aa. Equivalent to Rv2790c,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Probable ltp1,lipid-transfer protein, highly similar to many eukaryotic sterol-carrier proteins/lipid-transfer protein precursors (see first citation below) e.g. O62742|SCP2 STEROL CARRIER PROTEIN X from Oryctolagus cuniculus (Rabbit) (547 aa),FASTA scores: opt: 1710, E(): 6e-102, (63.7% identity in 394 aa overlap); Q9QW19 3-OXOACYL-CoA THIOLASE HOMOLOG (FRAGMENT) (see citation below) from Rattus sp. (405 aa),FASTA scores: opt: 1696, E(): 3.8e-101, (63.2% identity in 394 aa overlap); P11915|NLTP_RAT|SCP2|SCP-2 NONSPECIFIC LIPID-TRANSFER PROTEIN PRECURSOR from Rattus norvegicus (Rat) (547 aa), FASTA scores: opt: 1696, E(): 4.8e-101,(63.2% identity in 394 aa overlap); P32020|NLTP_MOUSE|SCP2|SCP-2 NONSPECIFIC LIPID-TRANSFER PROTEIN PRECURSOR from Mus musculus (Mouse) (547 aa),FASTA scores: opt: 1681, E(): 4.3e-100, (62.7% identity in 394 aa overlap); etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature and PS00737 Thiolases signature 2. Also similar to other M. tuberculosis proteins e.g. O06144|Rv1627c|MTCY01B2.19c (402 aa) (35.8% identity in 413 aa overlap).	Q7TXV4	No								IPR002155,IPR016038,IPR016039,IPR020613,IPR020615,IPR020616,IPR020617	Q7TXV4	A0A1R3Y282									
NC_002945.3	Mycobrowser_v4	CDS	3058913	3059809	.	-	0	Mb2816c	truB		PROBABLE TRNA PSEUDOURIDINE SYNTHASE B TRUB (TRNA PSEUDOURIDINE 55 SYNTHASE) (PSI55 SYNTHASE) (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE)	Mb2816c, truB, len: 298 aa. Equivalent to Rv2793c,len: 298 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 298 aa overlap). Probable truB, tRNA pseudouridine synthase (EC 4.2.1.70), equivalent to Q9Z5I4|TRUB_MYCLE|ML1546 OR MLCB596.24 TRNA PSEUDOURIDINE SYNTHASE B from Mycobacterium leprae (320 aa), FASTA scores: opt: 1403, E(): 2.9e-83, (74.05% identity in 293 aa overlap). Also highly similar to many e.g. Q9Z528|TRUB_STRCO|SC9F2.07c from Streptomyces coelicolor (301 aa), FASTA scores: opt: 870, E(): 7.6e-49, (50.7% identity in 296 aa overlap); P09171|TRUB_ECOLI|P35|B3166|Z4527|ECS4047 from Escherichia coli strains K12 and O157:H7 (314 aa), FASTA scores: opt: 574, E(): 1e-29, (42.5% identity in 214 aa overlap); Q9PGR1|TRUB_XYLFA|XF0237 from Xylella fastidiosa (302 aa),FASTA scores: opt: 569, E(): 2.1e-29, (41.05% identity in 285 aa overlap); etc. BELONGS TO THE TRUB FAMILY OF PSEUDOURIDINE SYNTHASES.	X2BLZ2,P62189	No									X2BLZ2,P62189	P62189									
NC_002945.3	Mycobrowser_v4	CDS	3059806	3060489	.	-	0	Mb2817c	pptt		phosphopantetheinyl transferase pptt (coa:apo-[acp]pantetheinephosphotransferase) (coa:apo-[acyl-carrier protein]pantetheinephosphotransferase)	Mb2817c, -, len: 227 aa. Equivalent to Rv2794c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 227 aa overlap). Conserved hypothetical protein, equivalent to Q9Z5I5|ML1547|MLCB596.23 PUTATIVE IRON-CHELATING COMPLEX SUBUNIT from Mycobacterium leprae (227 aa), FASTA scores: opt: 1248, E(): 9.1e-77, (79.75% identity in 227 aa overlap). Also highly similar to various proteins e.g. Q9F0Q6|PPTA PHOSPHOPANTETHEINYL TRANSFERASE from Streptomyces verticillus (246 aa), FASTA scores: opt: 692, E(): 2.8e-39, (46.65% identity in 225 aa overlap); O88029|SC5A7.23 HYPOTHETICAL 24.5 KDA PROTEIN from Streptomyces coelicolor (226 aa), FASTA scores: opt: 679, E(): 2e-38, (46.9% identity in 226 aa overlap); O24813 DNA FOR L-PROLINE 3-HYDROXYLASE from Streptomyces sp. (208 aa), FASTA scores: opt: 631, E(): 3.2e-35, (48.1% identity in 208 aa overlap); etc.	Q7TXV1	No	lipid metabolism							IPR003542,IPR008278	Q7TXV1	A0A1R3Y471				Rv2794c		Rv2794c			
NC_002945.3	Mycobrowser_v4	CDS	3061605	3062168	.	-	0	Mb2819c	lppV		PROBABLE CONSERVED LIPOPROTEIN LPPV	Mb2819c, lppV, len: 187 aa. Equivalent to Rv2796c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Probable lppV,conserved lipoprotein, similar to others from Mycobacterium tuberculosis e.g. P95009|LPPB|Rv2544|MTCY159.12c PROBABLE CONSERVED LIPOPROTEIN (220 aa), FASTA scores: opt: 168, E(): 0.00066, (22.45% identity in 196 aa overlap); and P95010|LPPA|RV2543|MTCY159.13c PROBABLE CONSERVED LIPOPROTEIN (219 aa), FASTA scores: opt: 165, E(): 0.001,(23.1% identity in 199 aa overlap).	Q7TXU9	No									Q7TXU9	A0A1R3Y2D7									
NC_002945.3	Mycobrowser_v4	CDS	3101741	3104443	.	-	0	Mb2864c	infB		PROBABLE TRANSLATION INITIATION FACTOR IF-2 INFB	Mb2864c, infB, len: 900 aa. Equivalent to Rv2839c,len: 900 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 900 aa overlap). Probable infB,translation initiation factor IF-2, highly similar, but in part, to Q9Z5I9|IF2_MYCLE|ML1556|MLCB596.14 TRANSLATION INITIATION FACTOR IF-2 from Mycobacterium leprae (924 aa),FASTA scores: opt: 4548, E(): 2.4e-132, (83.6% identity in 933 aa overlap). Also similar in part to others e.g. Q9K3E2|SC5H4.30 from Streptomyces coelicolor (835 aa),FASTA scores: opt: 2559, E(): 1.3e-71, (59.9% identity in 833 aa overlap); P17889|IF2_BACSU|INFB from Bacillus subtilis (716 aa), FASTA scores: opt: 1782, E(): 6.6e-48,(46.65% identity in 686 aa overlap); P02995|IF2_ECOLI|INFB|SSYG|B3168|Z4529|ECS4049 from Escherichia coli strains O157:H7 and K12 (890 aa), FASTA scores: opt: 1708, E(): 1.3e-45, (46.2% identity in 662 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE IF-2 FAMILY.	X2BM52,P65132	No									X2BM52,P65132	P65132									
NC_002945.3	Mycobrowser_v4	CDS	3066719	3067075	.	-	0	Mb2824c	mazf9		toxin mazf9	Mb2824c, -, len: 118 aa. Equivalent to Rv2801c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Conserved hypothetical protein, highly similar to Q9RWK4|DR0662 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (115 aa), FASTA scores: opt: 306, E(): 2e-15,(43.95% identity in 116 aa overlap); and similar to AAK78474|CAC0494 PEMK FAMILY OF DNA-BINDING PROTEINS from Clostridium acetobutylicum (122 aa), FASTA scores: opt: 217, E(): 7.3e-09, (33.35% identity in 117 aa overlap); P96622|YDCE YDCE PROTEIN from Bacillus subtilis (116 aa),FASTA scores: opt: 194, E(): 3.5e-07, (33.35% identity in 117 aa overlap); Q9PHH8|XFA0027 PLASMID MAINTENANCE PROTEIN from Xylella fastidiosa (108 aa), FASTA scores: opt: 188, E(): 9.1e-07, (40.85% identity in 115 aa overlap); etc. Also similar to Q10867|YJ91_MYCTU|Rv1991c|MT2046|MTCY39.28 HYPOTHETICAL 12.3 KDA PROTEIN from Mycobacterium tuberculosis (114 aa),FASTA scores: opt: 190, E(): 6.8e-07, (36.75% identity in 117 aa overlap).	Q7TXU4	No	virulence, detoxification, adaptation							IPR003477,IPR011067	Q7TXU4	A0A1R3Y286				Rv2801c		Rv2801c			
NC_002945.3	Mycobrowser_v4	CDS	3067059	3067289	.	-	0	Mb2824A	mazE9		Possible antitoxin MazE9	Mb2824A, len: 76 aa. Equivalent to Rv2801A len: 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 76 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazE9,antitoxin, part of toxin-antitoxin (TA) operon with Rv2801c (See Pandey and Gerdes, 2005; Zhu et al., 2006). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).	X2BLJ6	No	virulence, detoxification, adaptation								X2BLJ6	A0A1R3Y280				Rv2801A		Rv2801A			
NC_002945.3	Mycobrowser_v4	CDS	3071598	3071855	.	+	0	Mb2831	Mb2831		HYPOTHETICAL PROTEIN	Mb2831, -, len: 85 aa. Equivalent to Rv2808, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Hypothetical unknown protein.	Q7TXT7	No	conserved hypotheticals								Q7TXT7	A0A1R3Y283				Rv2808		Rv2808			
NC_002945.3	Mycobrowser_v4	CDS	3097058	3097885	.	-	0	Mb2858c	ugpE		PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPE	Mb2858c, ugpE, len: 275 aa. Equivalent to Rv2834c,len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 275 aa overlap). Probable ugpE,Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9KDY3|BH1078 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER from Bacillus halodurans (270 aa), FASTA scores: opt: 620, E(): 4.3e-32, (34.7% identity in 268 aa overlap); Q9X0K6|TM1122 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER PERMEASE PROTEIN from Thermotoga maritima (276 aa), FASTA scores: opt: 605, E(): 3.9e-31, (32.5% identity in 274 aa overlap); AAG58557|UGPE SN-GLYCEROL 3-PHOSPHATE TRANSPORT SYSTEM (INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain O157:H7 and EDL933 (281 aa), FASTA scores: opt: 574, E(): 3.7e-29, (32.95% identity in 264 aa overlap); P10906|UGPE_ECOLI|B3451 SN-GLYCEROL-3-PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN from Escherichia coli strain K12 (281 aa), FASTA scores: opt: 569, E(): 7.6e-29,(32.6% identity in 264 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.	Q7TXR3	No								IPR000515	Q7TXR3	A0A1R3Y2R8									
NC_002945.3	Mycobrowser_v4	CDS	3095745	3097055	.	-	0	Mb2857c	ugpB		PROBABLE Sn-GLYCEROL-3-PHOSPHATE-BINDING LIPOPROTEIN UGPB	Mb2857c, ugpB, len: 436 aa. Equivalent to Rv2833c,len: 436 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 436 aa overlap). Probable ugpB,Sn-glycerol-3-phosphate binding lipoprotein component of Sn-glycerol-3-phosphate transport system (see citation below), similar to various transporters substrate-binding periplasmic proteins e.g. Q9KDY2|BH1079 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (GLYCEROL-3-PHOSPHATE BINDING PROTEIN) from Bacillus halodurans (459 aa), FASTA scores: opt: 357, E(): 3.1e-14, (23.4% identity in 406 aa overlap); P72397|MALE PUTATIVE MALTOSE-BINDING PROTEIN from Streptomyces coelicolor (423 aa), FASTA scores: opt: 318, E(): 7e-12, (23.7% identity in 430 aa overlap); AAK78409|CAC0429 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER PERIPLASMIC COMPONENT from Clostridium acetobutylicum (447 aa), FASTA scores: opt: 305, E(): 4.5e-11, (27.15% identity in 438 aa overlap); P10904|UGPB_ECOLI|B3453 GLYCEROL-3-PHOSPHATE-BINDING PERIPLASMIC PROTEIN PRECURSOR from Escherichia coli strain K12 (438 aa); etc. Contains signal sequence and appropriately positioned prokaryotic lipoprotein attachment site (PS00013).	Q7TXR4	No								IPR006311	Q7TXR4	A0A1R3Y2H5									
NC_002945.3	Mycobrowser_v4	CDS	3093191	3093583	.	-	0	Mb2853c	vapc22		possible toxin vapc22	Mb2853c, -, len: 130 aa. Equivalent to Rv2829c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Conserved hypothetical protein similar to AAK65872|SMA2253 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (125 aa), FASTA scores: opt: 171,E(): 7.7e-05, (34.9% identity in 129 aa overlap); and shows some similarity with other proteins e.g. Q9AH69 HYPOTHETICAL 14.7 KDA PROTEIN from Neisseria meningitidis (128 aa), FASTA scores: opt: 148, E(): 0.0031, (28.1% identity in 121 aa overlap).	Q7TXR8	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TXR8	A0A1R3Y2A9				Rv2829c		Rv2829c			
NC_002945.3	Mycobrowser_v4	CDS	3276352	3279735	.	-	0	Mb2991c	pca		PROBABLE PYRUVATE CARBOXYLASE PCA (PYRUVIC CARBOXYLASE)	Mb2991c, pca, len: 1127 aa. Equivalent to Rv2967c,len: 1127 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1127 aa overlap). Probable pca,pyruvate carboxylase (ala-rich protein) (EC 6.4.1.1),equivalent to Q9F843|PYC PYRUVATE CARBOXYLASE from Mycobacterium smegmatis (1127 aa), FASTA scores: opt: 6232, E(): 0, (83.3% identity in 1127 aa overlap). Also highly similar to others e.g. Q9RK64|SCF11.26c PYRUVATE CARBOXYLASE from Streptomyces coelicolor (1124 aa), FASTA scores: opt: 5526, E(): 0, (74.65% identity in 1125 aa overlap); O54587|PYC PYRUVATE CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (1140 aa), FASTA scores: opt: 4811, E(): 0, (64.5% identity in 1132 aa overlap); Q9DDT1 PYRUVATE CARBOXYLASE from Brachydanio rerio (Zebrafish) (1180 aa), FASTA scores: opt: 3133, E(): 1.1e-171, (47.8% identity in 1142 aa overlap); etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2, PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site, and PS00188 Biotin-requiring enzymes attachment site.	Q7TXJ1	No								IPR000089,IPR000891,IPR001882,IPR003379,IPR005479,IPR005481,IPR005482,IPR005930,IPR011053,IPR011054,IPR011761,IPR011764,IPR013785,IPR013815,IPR013816,IPR016185	Q7TXJ1	A0A1R3Y2R6									
NC_002945.3	Mycobrowser_v4	CDS	3117096	3118577	.	-	0	Mb2877c	mqo		PROBABLE MALATE:QUINONE OXIDOREDUCTASE MQO (MALATE DEHYDROGENASE [ACCEPTOR])	Mb2877c, mqo, len: 493 aa. Equivalent to Rv2852c,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 493 aa overlap). Probable mqo,malate:quinone oxidoreductase (EC 1.1.99.16), highly similar to others e.g. O69282|MQO_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (499 aa), FASTA scores: opt: 1701, E(): 1.2e-101, (50.7% identity in 495 aa overlap); Q9Z9Q7|BH3960 from Bacillus halodurans (500 aa), FASTA scores: opt: 1632, E(): 3.3e-97, (48.55% identity in 486 aa overlap); Q9HYF4|MQOA|PA3452 from Pseudomonas aeruginosa (523 aa),FASTA scores: opt: 1604, E(): 2.1e-95, (49.1% identity in 487 aa overlap) (N-terminus longer); P33940|MQO_ECOLI|B2210 from Escherichia coli strain K12 (548 aa), FASTA scores: opt: 1525, E(): 2.7e-90, (48.15% identity in 492 aa overlap); etc. BELONGS TO THE MQO FAMILY. COFACTORS: FAD.	X2BM23,P65420	No									X2BM23,P65420	P65420									
NC_002945.3	Mycobrowser_v4	CDS	3093842	3094591	.	+	0	Mb2855	echA16		PROBABLE ENOYL-COA HYDRATASE ECHA16 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb2855, echA16, len: 249 aa. Equivalent to Rv2831,len: 249 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 249 aa overlap). Probable echA16,enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. O23468|AT4G16210 from Arabidopsis thaliana (Mouse-ear cress) (244 aa), FASTA scores: opt: 491, E(): 7.3e-25,(42.1% identity in 190 aa overlap); Q98LI4|MLL1009 from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 491, E(): 7.6e-25, (40.75% identity in 248 aa overlap); O07137|ECH8_MYCLE|ML2402|MLCB1306.05c from Mycobacterium leprae (257 aa), FASTA scores: opt: 478,E(): 5.3e-24, (38.05% identity in 226 aa overlap); P76082|PAAF_ECOLI|B1393 from scherichia coli strain K12 (255 aa), FASTA scores: opt: 439, E(): 1.9e-21, (37.55% identity in 221 aa overlap); etc. Also similar to O53418|ECH8_MYCTU|ECHA8|Rv1070c|MT1100|MTV017.23c from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 471, E(): 1.5e-23, (38.05% identity in 226 aa overlap).	Q7TXR6	No								IPR001753	Q7TXR6	A0A1R3Y498									
NC_002945.3	Mycobrowser_v4	CDS	3094670	3095752	.	-	0	Mb2856c	ugpC		PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER UGPC	Mb2856c, ugpC, len: 360 aa. Equivalent to Rv2832c,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 360 aa overlap). Probable ugpC,Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter (see first citation below), similar to others: CAC48805 PROBABLE GLYCEROL-3-PHOSPHATE ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (349 aa), FASTA scores: opt: 1018,E(): 4.1e-53, (48.6% identity in 356 aa overlap); Q98G42|MLL3499|UGPC SN-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN from Rhizobium loti (Mesorhizobium loti) (366 aa), FASTA scores: opt: 1016, E(): 5.6e-53,(48.5% identity in 367 aa overlap). But also highly similar to many msiK proteins, ABC transporter ATP-binding proteins possibly involved in transport of cellolbiose and maltose (see second citation below) e.g. P96483|MSIK MSIK PROTEIN from Streptomyces reticuli (see citation below) (377 aa), FASTA scores: opt: 1277, E(): 1.9e-68, (58.05% identity in 379 aa overlap); Q9L0Q1|MSIK ABC TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (378 aa),FASTA scores: opt: 1276, E(): 2.1e-68, (57.65% identity in 380 aa overlap); Q54333|MSIK from Streptomyces lividans (314 aa), FASTA scores: opt: 1217, E(): 5.9e-65, (63.7% identity in 292 aa overlap); and other ABC-TYPE SUGAR TRANSPORT PROTEINS. Also highly similar to O53482|Rv2038c|MTV018.25c ABC-TYPE SUGAR TRANSPORT PROTEIN from Mycobacterium tuberculosis (357 aa), FASTA scores: opt: 1248, E(): 9.4e-67, (56.8% identity in 354 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TXR5	No								IPR003439,IPR003593,IPR008995,IPR012340,IPR017871,IPR027417	Q7TXR5	A0A1R3Y349									
NC_002945.3	Mycobrowser_v4	CDS	3097882	3098424	.	-	0	Mb2859c	ugpAb		PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPAB [SECOND PART]	Mb2859c, ugpAb, len: 180 aa. Equivalent to 3' end of Rv2835c, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 180 aa overlap). Probable ugpA, Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below),similar to various permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR TRANSPORTER INNER MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35,(38.85% identity in 291 aa overlap); Q9KDY4|BH1077 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (315 aa), FASTA scores: opt: 548, E(): 6.2e-29, (31.5% identity in 295 aa overlap); AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER,PERMEASE COMPONENT from Clostridium acetobutylicum (304 aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity in 292 aa overlap); etc. Contains PS00062 Aldo/keto reductase family signature 2, and PS00402 Binding-protein-dependent transport systems inner membrane comp signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb.	Q7TXR2	No								IPR000515	Q7TXR2	A0A1R3Y2B5									
NC_002945.3	Mycobrowser_v4	CDS	3098421	3098792	.	-	0	Mb2860c	ugpAa		PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPAA [FIRST PART]	Mb2860c, ugpAa, len: 123 aa. Similar to 5' end of Rv2835c, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 85 aa overlap). Probable ugpA, Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR TRANSPORTER INNER MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35,(38.85% identity in 291 aa overlap); Q9KDY4|BH1077 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (315 aa), FASTA scores: opt: 548, E(): 6.2e-29, (31.5% identity in 295 aa overlap); AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER,PERMEASE COMPONENT from Clostridium acetobutylicum (304 aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity in 292 aa overlap); etc. Contains PS00062 Aldo/keto reductase family signature 2, and PS00402 Binding-protein-dependent transport systems inner membrane comp signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb.	Q7TXR1	No								IPR000515	Q7TXR1	A0A1R3Y2B6									
NC_002945.3	Mycobrowser_v4	CDS	3098879	3100198	.	-	0	Mb2861c	dinF		POSSIBLE DNA-DAMAGE-INDUCIBLE PROTEIN F DINF	Mb2861c, dinF, len: 439 aa. Equivalent to Rv2836c,len: 439 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 439 aa overlap). Possible dinF,DNA-damage-inducible protein F, integral membrane protein,similar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 (459 aa), FASTA scores: opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli strain K12 (459 aa), FASTA scores: opt: 491, E(): 1e-20,(29.35% identity in 443 aa overlap); Q98B90|MLR5680 from Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA scores: opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa overlap); etc. But also similar or highly similar to other hypothetical proteins e.g. Q9X8U6|SCH24.32c HYPOTHETICAL 46.3 KDA PROTEIN from Streptomyces coelicolor (448 aa),FASTA scores: opt: 981, E(): 1.1e-48, (42.35% identity in 437 aa overlap). Contains PS00213 Lipocalin signature.	Q7TXR0	No								IPR002528	Q7TXR0	A0A1R3Y2D3									
NC_002945.3	Mycobrowser_v4	CDS	3101190	3101741	.	-	0	Mb2863c	rbfA		PROBABLE RIBOSOME-BINDING FACTOR A RBFA (P15B PROTEIN)	Mb2863c, rbfA, len: 183 aa. Equivalent to Rv2838c,len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Probable rbfA,ribosome-binding factor A, equivalent to Q9Z5I8|RBFA_MYCLE|ML1555|MLCB596.15 PROBABLE RIBOSOME-BINDING FACTOR A from Mycobacterium leprae (164 aa), FASTA scores: opt: 739, E(): 1.8e-40, (75.6% identity in 160 aa overlap). Also highly similar or similar to others e.g. Q9Z527|RBFA_STRCO|SC9F2.08c from Streptomyces coelicolor (160 aa), FASTA scores: opt: 425, E(): 2.8e-20,(50.35% identity in 141 aa overlap); P32731|RBFA_BACSU from Bacillus subtilis (117 aa), FASTA scores: opt: 199,E(): 7.8e-06, (32.4% identity in 108 aa overlap); P09170|RBFA_ECOLI|P15B|B3167 from Escherichia coli strain K12 (132 aa), FASTA scores: opt: 166, E(): 0.0011, (29.65% identity in 118 aa overlap); etc. BELONGS TO THE RBFA FAMILY. Note that appears to be longer in C-terminus than other RbfA proteins.	X2BLP7,P65965	No									X2BLP7,P65965	P65965									
NC_002945.3	Mycobrowser_v4	CDS	3104955	3105998	.	-	0	Mb2866c	nusA		PROBABLE N UTILIZATION SUBSTANCE PROTEIN A NUSA	Mb2866c, nusA, len: 347 aa. Equivalent to Rv2841c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Probable nusA,N-utilization substance protein A, equivalent to Q9Z5J1|NUSA|ML1558 PROBABLE TRANSCRIPTION TERMINATION/ANTITERMINATION FACTOR from Mycobacterium leprae (347 aa), FASTA scores: opt: 2054, E(): 5.4e-120,(91.95% identity in 347 aa overlap). Also highly similar to others e.g. Q9KYR1|SC5H4.28 PUTATIVE TRANSCRIPTIONAL TERMINATION/ANTITERMINATION FACTOR from Streptomyces coelicolor (340 aa), FASTA scores: opt: 1346, E(): 4.3e-76, (63.35% identity in 341 aa overlap); P32727|NUSA_BACSU N UTILIZATION SUBSTANCE PROTEIN A (371 aa), FASTA scores: opt: 847, E(): 4.1e-45, (43.95% identity in 346 aa overlap); Q9KA74|NUSA|BH2416 TRANSCRIPTIONAL TERMINATOR from Bacillus halodurans (382 aa), FASTA scores: opt: 846, E(): 4.8e-45, (43.15% identity in 373 aa overlap); etc. BELONGS TO THE NUSA FAMILY.	X2BLQ9,P0A5M3	No									X2BLQ9,P0A5M3	P0A5M3									
NC_002945.3	Mycobrowser_v4	CDS	3128143	3129516	.	-	0	Mb2885c	glnA4		PROBABLE GLUTAMINE SYNTHETASE GLNA4 (GLUTAMINE SYNTHASE) (GS-II)	Mb2885c, glnA4, len: 457 aa. Equivalent to Rv2860c,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 457 aa overlap). Probable glnA4,glutamine synthetase class II (EC 6.3.1.2), similar to many glutamine synthases e.g. O88070|SCI35.35c from Streptomyces coelicolor (462 aa), FASTA scores: opt: 1947,E(): 8.2e-120, (64.15% identity in 452 aa overlap); Q98H15|MLL3074 from Rhizobium loti (Mesorhizobium loti) (465 aa), FASTA scores: opt: 1321, E(): 7.8e-79, (46.7% identity in 452 aa overlap); Q98EM0|MLL4187 from Rhizobium loti (Mesorhizobium loti) (456 aa), FASTA scores: opt: 698, E(): 4.6e-38, (33.5% identity in 454 aa overlap); Q9CDL9|GLNA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (446 aa), FASTA scores: opt: 633,E(): 8.2e-34, (32.45% identity in 456 aa overlap); etc. Also similar to three other potential glutamine synthases in Mycobacterium tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427 .03c PROBABLE GLUTAMINE SYNTHETASE (446 aa), FASTA score: (31.1% identity in 453 aa overlap); Rv1878|glnA3 and Rv2220|glnA1. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY.	Q7TXP3	No								IPR008146,IPR008147,IPR014746	Q7TXP3	A0A1R3Y4D4									
NC_002945.3	Mycobrowser_v4	CDS	3107772	3109520	.	-	0	Mb2870c	proS		probable prolyl-trna synthetase pros (proline--trna ligase) (prors) (global rna synthesis factor) (proline translase)	Mb2870c, proS, len: 582 aa. Equivalent to Rv2845c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 582 aa overlap). Probable proS,prolyl-tRNA synthetase (EC 6.1.1.15), highly similar to others e.g. Q9KYR6|SYP_STRCO|PROS|SC5H4.23 from Streptomyces coelicolor (567 aa), FASTA scores: opt: 1161,E(): 9e-64, (57.15% identity in 574 aa overlap); P56124|SYP_HELPY|PROS|HP0238 from Helicobacter pylori (Campylobacter pylori) (577 aa), FASTA scores: opt: 1082,E(): 6.6e-59, (37.8% identity in 553 aa overlap); P16659|SYP_ECOLI|PROS|DRPA|B0194 from Escherichia coli strain K12 (572 aa), FASTA scores: opt: 926, E(): 2.6e-49,(39.85% identity in 587 aa overlap); etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BMK4,Q7TXQ5	No									X2BMK4,Q7TXQ5	Q7TXQ5									
NC_002945.3	Mycobrowser_v4	CDS	3109609	3111201	.	-	0	Mb2871c	efpA		POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA	Mb2871c, efpA, len: 530 aa. Equivalent to Rv2846c,len: 530 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 530 aa overlap). Possible efpA,integral membrane efflux protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug (see citations below), equivalent to Q9Z5J5|ML1562|MLCB596.08 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Mycobacterium leprae (534 aa), FASTA scores: opt: 2881, E(): 4.1e-160, (86.55% identity in 535 aa overlap). Also highly similar to several membrane proteins e.g. O69986|SC4H2.31c TRANSMEMBRANE EFFLUX PROTEIN (515 aa), FASTA scores: opt: 1063, E(): 2.2e-54, (39.65% identity in 406 aa overlap); Q9FBQ5|SCD86A.02c PUTATIVE TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (503 aa), FASTA scores: opt: 918, E(): 5.8e-46,(33.7% identity in 469 aa overlap); Q9KYU0|SCE22.23c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (514 aa), FASTA scores: opt: 888, E(): 3.3e-44,(32.85% identity in 469 aa overlap); etc.	Q7TXQ4	No								IPR011701,IPR016196,IPR020846	Q7TXQ4	A0A1R3Y2D5									
NC_002945.3	Mycobrowser_v4	CDS	3112664	3114037	.	-	0	Mb2873c	cobB		PROBABLE COBYRINIC ACID A,C-DIAMIDE SYNTHASE COBB	Mb2873c, cobB, len: 457 aa. Equivalent to Rv2848c,len: 457 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 457 aa overlap). Probable cobB,cobyrinic acid A,C-diamide synthase, highly similar to others e.g. O27509|COBB_METTH|MTH1460 from Methanobacterium thermoautotrophicum (447 aa), FASTA scores: opt: 980, E(): 1.3e-49, (39.65% identity in 454 aa overlap); Q9KBM8|BH1898 from Bacillus halodurans (465 aa),FASTA scores: opt: 928, E(): 1.4e-46, (37.0% identity in 457 aa overlap); O68108|COBB_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (435 aa), FASTA scores: opt: 921, E(): 3.3e-46, (39.35% identity in 437 aa overlap); etc. BELONGS TO THE COBB/COBQ FAMILY, COBB SUBFAMILY.	X2BLS0,P63836	No									X2BLS0,P63836	P63836									
NC_002945.3	Mycobrowser_v4	CDS	3114037	3114660	.	-	0	Mb2874c	cobO		PROBABLE COB(I)ALAMIN ADENOSYLTRANSFERASE COBO (CORRINOID ADENOSYLTRANSFERASE) (CORRINOID ADOTRANSFERASE ACTIVITY)	Mb2874c, cobO, len: 207 aa. Equivalent to Rv2849c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 207 aa overlap). Probable cobO,cob(I)alamin adenosyltransferase (EC 2.5.1.17), highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75% identity in 207 aa overlap); and similar to others e.g. O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212 aa), FASTA scores: opt: 329, E(): 2.8e-15,(44.3% identity in 185 aa overlap); P29930|COBO_PSEDE from Pseudomonas denitrificans (213 aa), FASTA scores: opt: 280, E(): 6.5e-12, (38.9% identity in 185 aa overlap); P31570|BTUR_SALTY|COBA from Salmonella typhimurium (196 aa), FASTA scores: opt: 278, E(): 8.4e-12, (39.8% identity in 196 aa overlap); etc. COFACTOR: MANGANESE. Note that previously known as cobA.	Q7TXQ2	No								IPR003724,IPR027417	Q7TXQ2	A0A1R3Y2E7									
NC_002945.3	Mycobrowser_v4	CDS	3143546	3144127	.	+	0	Mb2900	mpt70		major secreted immunogenic protein mpt70	Mb2900, mpb70, len: 193 aa. Equivalent to Rv2875,len: 193 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 193 aa overlap). mpt70 (alternate gene name: mpb70), major secreted immunogenic protein MPT70 precursor (see citations below). Also similar to downstream ORF Q10790|MP83_MYCTU|MPT83|MPB83|Rv2873|MT2940|MTCY274.04 CELL SURFACE LIPOPROTEIN MPT83 PRECURSOR (LIPOPROTEIN P23) (220 aa), FASTA scores: opt: 806, E(): 1.2e-40, (70.25% identity in 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FAMILY. GENERALLY FOUND AS A MONOMER; HOMODIMER IN CULTURE FLUIDS.	X2BLT4,P0A669	No									X2BLT4,P0A669	P0A669									
NC_002945.3	Mycobrowser_v4	CDS	3139654	3139911	.	+	0	Mb2896	vapb43		possible antitoxin vapb43	Mb2896, -, len: 85 aa. Equivalent to Rv2871, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein (see citation below), similar to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50456|Rv1241|MTV006.13 (86 aa), FASTA scores: opt: 172, E(): 2.9e-05, (37.2% identity in 86 aa overlap); O53811|Rv0748|MTV041.22 (85 aa), FASTA scores: opt: 170, E(): 4e-05, (35.3% identity in 85 aa overlap); etc.	X2BM36,P0A5H0	No	virulence, detoxification, adaptation								X2BM36,P0A5H0	P0A5H0				Rv2871		Rv2871			
NC_002945.3	Mycobrowser_v4	CDS	3118784	3120631	.	+	0	Mb2878	PE_PGRS48		pe-pgrs family protein pe_pgrs48	Mb2878, PE_PGRS48, len: 615 aa. Equivalent to Rv2853, len: 615 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 615 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to many e.g. O53884|Rv0872c|MTV043.65c from Mycobacterium tuberculosis (606 aa), FASTA scores: opt: 1405, E(): 1.4e-97, (64.6% identity in 619 aa overlap). Equivalent to AAK47245 from Mycobacterium tuberculosis strain CDC1551 (663 aa) but shorter 48 aa.	Q7TXQ0	No								IPR000084	Q7TXQ0	A0A1R3Y2T7									
NC_002945.3	Mycobrowser_v4	CDS	3121721	3123100	.	+	0	Mb2880	mtr		nadph-dependent mycothiol reductase mtr	Mb2880, mtr, len: 459 aa. Equivalent to Rv2855,len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable mtr,mycothiol reductase (EC 1.-.-.-), proven enzymatically but previously described as glutathione reductase homolog (gene name: gorA) (see citation below). Similar to others e.g. Q9L7K8|MERA MERCURIC REDUCTASE from Streptomyces sp. CHR28 (474 aa), FASTA scores: opt: 719, E(): 9e-38, (35.2% identity in 460 aa overlap); P30341|MERA_STRLI MERCURIC REDUCTASE (EC 1.16.1.1) from Streptomyces lividans (474 aa), FASTA scores: opt: 712, E(): 2.5e-37, (34.95% identity in 455 aa overlap); Q98ED5|MLL4296 FERRIC LEGHEMOGLOBIN REDUCTASE-2 PRECURSOR, DIHYDROLIPOAMIDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (468 aa), FASTA scores: opt: 670, E(): 1.1e-34, (30.8% identity in 471 aa overlap); etc. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD.	Q7TXP8	No	intermediary metabolism and respiration							IPR001327,IPR004099,IPR012999,IPR013027,IPR016156,IPR017817,IPR023753	Q7TXP8	A0A1R3Y2E2				Rv2855		Rv2855			
NC_002945.3	Mycobrowser_v4	CDS	3123200	3124318	.	+	0	Mb2881	nicT		POSSIBLE NICKEL-TRANSPORT INTEGRAL MEMBRANE PROTEIN NICT	Mb2881, nicT, len: 372 aa. Equivalent to Rv2856,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 372 aa overlap). Possible nicT,nickel-transport integral membrane protein, similar to transport proteins and hydrogenase cluster proteins e.g. BAB58860|SAV2698 HYPOTHETICAL 37.9 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (338 aa), FASTA scores: opt: 1082, E(): 7.1e-60, (48.05% identity in 335 aa overlap); Q97ZB2|HOXN HIGH-AFFINITY NICKEL-TRANSPORT PROTEIN from Sulfolobus solfataricus (373 aa), FASTA scores: opt: 922, E(): 6.6e-50, (42.2% identity in 372 aa overlap); P23516|HOXN_ALCEU HIGH-AFFINITY NICKEL TRANSPORT PROTEIN (INTEGRAL MEMBRANE PROTEIN) from Alcaligenes eutrophus (Ralstonia eutropha) (351 aa), FASTA scores: opt: 904, E(): 8.3e-49, (41.9% identity in 339 aa overlap); Q45247|HUPN_BRAJA HYDROGENASE NICKEL INCORPORATION PROTEIN from Bradyrhizobium japonicum (381 aa), FASTA scores: opt: 853, E(): 1.3e-45, (41.65% identity in 329 aa overlap); etc. SEEMS TO BELONG TO THE HOXN/HUPN/NIXA FAMILY OF NICKEL TRANSPORTERS (NiCoT FAMILY).	Q7TXP7	No	cell wall and cell processes							IPR004688,IPR011541	Q7TXP7	A0A1R3Y2E6				Rv2856		Rv2856			
NC_002945.3	Mycobrowser_v4	CDS	3125872	3127239	.	-	0	Mb2883c	aldC		PROBABLE ALDEHYDE DEHYDROGENASE ALDC	Mb2883c, aldC, len: 455 aa. Equivalent to Rv2858c,len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 455 aa overlap). Probable aldC,aldehyde dehydrogenase (EC 1.2.1.3), similar to many e.g. O88069|SCI35.34c PUTATIVE ALDEHYDE DEHYDROGENASE from Streptomyces coelicolor (483 aa), FASTA scores: opt: 1872,E(): 6.4e-109, (64.5% identity in 448 aa overlap); Q9FAB1|ALDH|BT-ALDH ALDEHYDE DEHYDROGENASE from Bacillus thermoleovorans (497 aa), FASTA scores: opt: 1157, E(): 2.1e-64, (44.3% identity in 458 aa overlap); O33455|CYMC P-CUMIC ALDEHYDE DEHYDROGENASE from Pseudomonas putida (494 aa), FASTA scores: opt: 1149, E(): 6.5e-64, (43.15% identity in 452 aa overlap); P40047|DHA5_YEAST|ALD5|ALDH5|ALD3|YER073W ALDEHYDE DEHYDROGENASE from Saccharomyces cerevisiae (Baker's yeast) (519 aa), FASTA scores: opt: 1091, E(): 2.7e-60,(38.55% identity in 459 aa overlap); P80668|FEAB_ECOLI|PADA|MAOB|B1385 PHENYLACETALDEHYDE DEHYDROGENASE (EC 1.2.1.39) from Escherichia coli strain K12 (499 aa), FASTA scores: opt: 1074, E(): 3e-59, (42.2% identity in 462 aa overlap); etc. Also similar to many M. tuberculosis dehydrogenases e.g. P71823|Rv0768|MTCY369.13 (489 aa), FASTA score: (38.1% identity in 467 aa overlap). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.	Q7TXP5	No								IPR015590,IPR016160,IPR016161,IPR016162,IPR016163	Q7TXP5	A0A1R3Y2F3									
NC_002945.3	Mycobrowser_v4	CDS	3135884	3137047	.	-	0	Mb2893c	gcpE		PROBABLE GCPE PROTEIN	Mb2893c, gcpE, len: 387 aa. Equivalent to Rv2868c,len: 387 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 387 aa overlap). Probable gcpE protein (protein e), equivalent to Q9CBU5|GCPE|ML1581 HYPOTHETICAL PROTEIN GCPE from Mycobacterium leprae (392 aa), FASTA scores: opt: 2247, E(): 6.8e-134, (87.65% identity in 388 aa overlap). Highly similar to essential gene of unknown function from Escherichia coli and other prokaryotes e.g. Q9X7W2|GCPE_STRCO|SC6A5.16 GCPE PROTEIN HOMOLOG from Streptomyces coelicolor (384 aa), FASTA scores: opt: 1965,E(): 3.8e-116, (78.2% identity in 385 aa overlap); P54482|GCPE_BACSU GCPE PROTEIN HOMOLOG from Bacillus subtilis (377 aa), FASTA scores: opt: 1157, E(): 2.6e-65,(49.55% identity in 351 aa overlap); P27433|GCPE_ECOLI|B2515|Z3778|ECS3377 GCPE PROTEIN (PROTEIN E) from Escherichia coli strains K12 and O157:H7 (372 aa), FASTA scores: opt: 984, E(): 2e-54, (44.15% identity in 360 aa overlap); etc. BELONGS TO THE GCPE FAMILY.	X2BM90,Q7TXN6	No									X2BM90,Q7TXN6	Q7TXN6									
NC_002945.3	Mycobrowser_v4	CDS	3137064	3138278	.	-	0	Mb2894c	rip		membrane bound metalloprotease	Mb2894c, -, len: 404 aa. Equivalent to Rv2869c,len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 404 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CBU4|ML1582 PROBABLE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (404 aa), FASTA scores: opt: 2250, E(): 1.1e-128,(82.2% identity in 404 aa overlap). Also weakly similar to other membrane proteins or hypothetical proteins e.g. Q9A710|CC1916 PUTATIVE MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE from Caulobacter crescentus (398 aa),FASTA scores: opt: 368, E(): 7.8e-15, (28.1% identity in 427 aa overlap).	Q7TXN5	No	cell wall and cell processes							IPR001478,IPR008915	Q7TXN5	A0A1R3Y4F1				Rv2869c		Rv2869c			
NC_002945.3	Mycobrowser_v4	CDS	3129676	3130533	.	-	0	Mb2886c	mapB		methionine aminopeptidase mapb (map) (peptidase m)	Mb2886c, mapB, len: 285 aa. Equivalent to Rv2861c,len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 285 aa overlap). Probable mapB (alternate gene name: map), methionine aminopeptidase (EC 3.4.11.18), equivalent to Q9CBU7|MAPB|ML1576 METHIONINE AMINOPEPTIDASE from Mycobacterium leprae (285 aa), FASTA scores: opt: 1729, E(): 1e-99, (89.75% identity in 283 aa overlap). Also highly similar to many e.g. Q9RKR2|MAP3 from Streptomyces coelicolor (285 aa), FASTA scores: opt: 1385, E(): 2e-78, (70.65% identity in 283 aa overlap); Q9SW64|C7A10.320|AT4G37040 from Arabidopsis thaliana (Mouse-ear cress) (305 aa), FASTA scores: opt: 914, E(): 3e-49, (50.35% identity in 286 aa overlap); P07906|AMPM_ECOLI|MAP|B0168|Z0178|ECS0170 from Escherichia coli strains K12 and O157:H7 (264 aa), FASTA scores: opt: 793, E(): 8.5e-42, (51.0% identity in 245 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT. Note that this gene has an N-terminal extension present in the human map, but not in the prokaryotic map's. An alternative start, with RBS, will give a protein equivalent to the shorter prokaryotic map's.	X2BLS3,P0A5J3	No									X2BLS3,P0A5J3	P0A5J3									
NC_002945.3	Mycobrowser_v4	CDS	3131317	3131511	.	+	0	Mb2887A	vapB23		Possible antitoxin VapB23	Mb2887A, len: 64 aa. Equivalent to Rv2862A len: 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 64 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB23,antitoxin,part of toxin-antitoxin (TA) operon with Rv2863 (See Pandey and Gerdes, 2005).	X2BLT8	No	virulence, detoxification, adaptation								X2BLT8	A0A1R3Y2U8				Rv2862A		Rv2862A			
NC_002945.3	Mycobrowser_v4	CDS	3131508	3131888	.	+	0	Mb2888	vapc23		possible toxin vapc23	Mb2888, -, len: 126 aa. Equivalent to Rv2863, len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Q50595|YI38_MYCTU|Rv1838c|MT1886|MTCY1A11.05|MTCY359.35 CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA scores: opt: 299, E(): 6.5e-15, (39.0% identity in 123 aa overlap).	Q7TXP1	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TXP1	A0A1R3Y2E4				Rv2863		Rv2863			
NC_002945.3	Mycobrowser_v4	CDS	3134053	3134334	.	+	0	Mb2890	relf		antitoxin relf	Mb2890, -, len: 93 aa. Equivalent to Rv2865, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein, showing weak similarity with P58235|YR54_SYNY3|SSR2754 HYPOTHETICAL 9.7 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (87 aa), FASTA scores: opt: 134, E(): 0.007, (30.65% identity in 75 aa overlap); BAB58570|SAV2408 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (83 aa),FASTA scores: opt: 124, E(): 0.037, (27.5% identity in 80 aa overlap). Also similar to Rv1247|MTV006.19c HYPOTHETICAL 9.8 KDA PROTEIN from Mycobacterium tuberculosis (89 aa), FASTA scores: opt: 249, E(): 2.6e-11, (44.2% identity in 86 aa overlap).	Q7TXN9	No	virulence, detoxification, adaptation							IPR006442	Q7TXN9	A0A1R3Y2G0				Rv2865		Rv2865			
NC_002945.3	Mycobrowser_v4	CDS	3138286	3139527	.	-	0	Mb2895c	dxr		PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE)	Mb2895c, dxr, len: 413 aa. Equivalent to Rv2870c,len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable dxr,1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.-), equivalent to Q9CBU3|DXR|ML1583 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE from Mycobacterium leprae (406 aa), FASTA scores: opt: 2145,E(): 1e-124, (84.05% identity in 395 aa overlap). Also highly similar to others e.g. Q9AJD7|DXR from Kitasatospora griseola (Streptomyces griseolosporeus) (386 aa), FASTA scores: opt: 1176, E(): 5.2e-65, (56.45% identity in 388 aa overlap); Q9KYS1|DXR_STRCO|SC5H4.18 from Streptomyces coelicolor (401 aa), FASTA scores: opt: 1079, E(): 5.1e-59, (52.25% identity in 396 aa overlap); P45568|DXR|B0173 from Escherichia coli strain K12 (398 aa), FASTA scores: opt: 120, E(): 0.032, (52.9% identity in 34 aa overlap); etc. Contains PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. BELONGS TO THE DXR FAMILY. N-terminus shortened since first submission.	X2BLS9,P64013	No									X2BLS9,P64013	P64013									
NC_002945.3	Mycobrowser_v4	CDS	3139898	3140341	.	+	0	Mb2897	vapc43		possible toxin vapc43. contains pin domain.	Mb2897, -, len: 147 aa. Equivalent to Rv2872, len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Conserved hypothetical protein (see citation below), similar to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53683|Rv0277c|MTV035.05c (142 aa), FASTA scores: opt: 357, E(): 1.4e-17, (41.45% identity in 140 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 350,E(): 4.3e-17, (41.55% identity in 142 aa overlap); etc.	X2BLV0,P65044	No	virulence, detoxification, adaptation								X2BLV0,P65044	P65044				Rv2872		Rv2872			
NC_002945.3	Mycobrowser_v4	CDS	3141363	3143450	.	+	0	Mb2899	dipZ		POSSIBLE INTEGRAL MEMBRANE C-TYPE CYTOCHROME BIOGENESIS PROTEIN DIPZ	Mb2899, dipZ, len: 695 aa. Equivalent to Rv2874,len: 695 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 695 aa overlap). Possible dipZ,cytochrome c-type biogenesis protein (see citation below),probable integral membrane protein, similar in part to others or hypothetical proteins e.g. CAC48606|SMB20213 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (627 aa), FASTA scores: opt: 844,E(): 7.3e-43, (32.65% identity in 643 aa overlap); Q9ZMH0|CCDA OR JHP0250 PUTATIVE CYTOCHROME C-TYPE BIOGENESIS PROTEIN from Helicobacter pylori J99 (Campylobacter pylori J99) (239 aa), FASTA scores: opt: 250, E(): 1.4e-07, (27.3% identity in 227 aa overlap); Q9LA04|CCDA C-TYPE CYTOCHROME BIOGENESIS PROTEIN from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (252 aa), FASTA scores: opt: 245, E(): 2.9e-07, (27.85% identity in 244 aa overlap); etc. Also similar to O06393|CCSA|Rv0527|MTCY25D10.06 CYTOCHROME C-TYPE BIOGENESIS PROTEIN from Mycobacterium tuberculosis (259 aa), FASTA scores: opt: 280, E(): 2.4e-09, (29.3% identity in 239 aa overlap).	X2BMN3,P59960	No	intermediary metabolism and respiration								X2BMN3,P59960	P59960				Rv2874		Rv2874			
NC_002945.3	Mycobrowser_v4	CDS	3207645	3212261	.	+	0	Mb2957	ppsB		PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Mb2957, ppsB, len: 1538 aa. Equivalent to Rv2932,len: 1538 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1538 aa overlap). ppsB, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE (1540 aa), FASTA scores: opt: 7284, E(): 0, (76.3% identity in 1561 aa overlap); Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE SYNTHASE (1446 aa), FASTA scores: opt: 6811, E(): 0, (76.2% identity in 1462 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. Q9KIZ6|EPOE EPOE PROTEIN from Polyangium cellulosum (3798 aa), FASTA scores: opt: 3052, E(): 3.3e-165, (38.35% identity in 1538 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10977|PPSA_MYCTU|RV2931 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FASTA scores: opt: 4227,E(): 0, (46.9% identity in 1810 aa overlap); P96203|PPSD|Rv2934|MTCY19H9.02 PKSE PROTEIN (1827 aa),FASTA scores: opt: 3756, E(): 1.8e-205, (42.9% identity in 1808 aa overlap); etc. Overlaps and extends CDS from neighbouring cosmid MTCY338.21. Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2932|ppsB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	X2BM25,Q7TXL9	No									X2BM25,Q7TXL9	Q7TXL9									
NC_002945.3	Mycobrowser_v4	CDS	3145392	3145913	.	-	0	Mb2903c	mpt53		soluble secreted antigen mpt53 precursor	Mb2903c, mpb53, len: 173 aa. Equivalent to Rv2878c,len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 173 aa overlap). mpt53, secreted protein (contains N-terminal signal sequence) (see citations below). Shows some similarity with several disulfide bond interchange proteins e.g. P43787|THIX_HAEIN THIOREDOXIN-LIKE PROTEIN HI1115 from Haemophilus influenzae (167 aa), FASTA scores: opt: 200, E(): 1.4e-06,(28.9% identity in 135 aa overlap); P52237|TIPB_PSEFL THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR (CYTOCHROME C BIOGENESIS PROTEIN TIPB) (178 aa), FASTA scores: opt: 184, E(): 1.8e-05, (26.3% identity in 171 aa overlap); etc. Also highly similar to O53924|DSBF|Rv1677|MTV047.12 PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (182 aa), FASTA scores: opt: 482, E(): 5.7e-26, (52.8% identity in 142 aa overlap). COULD BE BELONG TO THE THIOREDOXIN FAMILY. Note that also previously known as dsbE.	X2BMA0,P0A619	No									X2BMA0,P0A619	P0A619									
NC_002945.3	Mycobrowser_v4	CDS	3147216	3148136	.	-	0	Mb2905c	cdsA		PROBABLE INTEGRAL MEMBRANE PHOSPHATIDATE CYTIDYLYLTRANSFERASE CDSA (CDP-DIGLYCERIDE SYNTHETASE) (CDP-DIGLYCERIDE PYROPHOSPHORYLASE) (CDP-DIACYLGLYCEROL SYNTHASE) (CDS) (CTP:PHOSPHATIDATE CYTIDYLYLTRANSFERASE) (CDP-DAG SYNTHASE) (CDP-DG SYNTHETASE)	Mb2905c, cdsA, len: 306 aa. Equivalent to Rv2881c,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 306 aa overlap). Probable cdsA,phosphatidate cytidylyltransferase (EC 2.7.7.41), integral membrane protein, equivalent to Q9CBU1|CDSA_MYCLE|ML1589 PHOSPHATIDATE CYTIDYLYLTRANSFERASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 1470, E(): 1.1e-84,(70.3% identity in 313 aa overlap). Also similar to others e.g. Q9KPV7|VC2255 from Vibrio cholerae (280 aa), FASTA scores: opt: 383, E(): 1.1e-16, (29.3% identity in 280 aa overlap); Q9CDT2|CDSA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (267 aa), FASTA scores: opt: 361, E(): 2.6e-15, (29.05% identity in 265 aa overlap); P06466|CDSA_ECOLI|CDS|B0175|Z0186|ECS0177 from Escherichia coli strains K12 and O157:H7 (249 aa), FASTA scores: opt: 352, E(): 9.2e-15, (40.4% identity in 156 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CDS FAMILY.	X2BLT6,P63759	No									X2BLT6,P63759	P63759									
NC_002945.3	Mycobrowser_v4	CDS	3148159	3148716	.	-	0	Mb2906c	frr		RIBOSOME RECYCLING FACTOR FRR (RIBOSOME RELEASING FACTOR) (RRF)	Mb2906c, frr, len: 185 aa. Equivalent to Rv2882c,len: 185 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 185 aa overlap). Probable frr,ribosome recycling factor, equivalent to O33046|RRF_MYCLE|FRR|ML1590|MLCB250.76 RIBOSOME RECYCLING FACTOR from Mycobacterium leprae (185 aa), FASTA scores: opt: 1063, E(): 2.6e-60, (90.8% identity in 185 aa overlap). Also highly similar to others e.g. O86770|RRF_STRCO|FRR|SC6A9.40c from Streptomyces coelicolor (185 aa), FASTA scores: opt: 783, E(): 1.5e-42,(63.25% identity in 185 aa overlap); P81101|RRF_BACSU|FRR from Bacillus subtilis (184 aa), FASTA scores: opt: 640,E(): 1.7e-33, (51.65% identity in 182 aa overlap); P16174|RRF_ECOLI|FRR|B0172|Z0183|ECS0174 from Escherichia coli strains K12 and O157:H7 (185 aa), FASTA scores: opt: 473, E(): 1.4e-23, (40.2% identity in 184 aa overlap); etc. BELONGS TO THE RRF FAMILY.	X2BM41,P66735	No									X2BM41,P66735	P66735									
NC_002945.3	Mycobrowser_v4	CDS	3148888	3149673	.	-	0	Mb2907c	pyrH		PROBABLE URIDYLATE KINASE PYRH (UK) (URIDINE MONOPHOSPHATE KINASE) (UMP KINASE)	Mb2907c, pyrH, len: 261 aa. Equivalent to Rv2883c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable pyrH,uridylate kinase (EC 2.7.4.-), equivalent to O33045|PYRH_MYCLE|ML1591|MLCB250.75 URIDYLATE KINASE from Mycobacterium leprae (279 aa), FASTA scores: opt: 1437,E(): 3.8e-81, (85.05% identity in 274 aa overlap). Also highly similar to others e.g. O69913|PYRH from Streptomyces coelicolor (253 aa), FASTA scores: opt: 1086,E(): 1.4e-59, (68.9% identity in 251 aa overlap); P74457|PYRH_SYNY3|SLL0144 from Synechocystis sp. strain PCC 6803 (260 aa), FASTA scores: opt: 851, E(): 4.1e-45,(55.85% identity in 231 aa overlap); P29464|PYRH_ECOLI|SMBA|B0171|Z0182|ECS0173 from strains K12 and O157:H7 (240 aa), FASTA scores: opt: 666, E(): 1.1e-35, (45.7% identity in 232 aa overlap); etc.	X2BLW4,P65930	No									X2BLW4,P65930	P65930									
NC_002945.3	Mycobrowser_v4	CDS	3153380	3154801	.	-	0	Mb2912c	amiC		PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	Mb2912c, amiC, len: 473 aa. Equivalent to Rv2888c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 473 aa overlap). Probable amiC,amidase (EC 3.5.1.4), equivalent to O33040|AMI3_MYCLE|AMIC|ML1596|MLCB250.65 PUTATIVE AMIDASE AMIC from Mycobacterium leprae (468 aa), FASTA scores: opt: 2361, E(): 4.2e-139, (76.7% identity in 468 aa overlap). Also similar to others e.g. Q9A8N0|CC1323 PUTATIVE 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE from Caulobacter crescentus (521 aa), FASTA scores: opt: 925,E(): 7.4e-50, (36.55% identity in 465 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC 3.5.1.4) from Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 659, E(): 2.2e-33, (31.1% identity in 460 aa overlap); Q55424|AMID_SYNY3|SLL0828 PUTATIVE AMIDASE from Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores: opt: 643, E(): 2.4e-32, (30.7% identity in 466 aa overlap); etc. Also similar to O05835|AMI1_MYCTU|AMIA2|Rv2363|MT2432|MTCY27.17c PUTATIVE AMIDASE AMIA2 (484 aa), FASTA scores: opt: 656, E(): 3.6e-33, (35.9% identity in 465 aa overlap); and Q11056|AMI2_MYCTU|AMIB2|Rv1263|MT1301|MTCY50.19c PUTATIVE AMIDASE from Mycobacterium tuberculosis (462 aa), FASTA scores: opt: 650, E(): 8.2e-33, (33.45% identity in 472 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-poop). BELONGS TO THE AMIDASE FAMILY.	X2BLX1,P63495	No									X2BLX1,P63495	P63495									
NC_002945.3	Mycobrowser_v4	CDS	3154808	3155623	.	-	0	Mb2913c	tsf		PROBABLE ELONGATION FACTOR TSF (EF-TS)	Mb2913c, tsf, len: 271 aa. Equivalent to Rv2889c,len: 271 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 271 aa overlap). Probable tsf,elongation factor, equivalent to O33039|EFTS_MYCLE|TSF|ML1597|MLCB250.64 ELONGATION FACTOR from Mycobacterium leprae (276 aa), FASTA scores: opt: 1430, E(): 1.9e-80, (83.7% identity in 276 aa overlap). Also highly similar to others e.g. Q9X5Z9|EFTS_STRRA|TSF from Streptomyces ramocissimus (278 aa), FASTA scores: opt: 928, E(): 1.1e-49, (57.05% identity in 277 aa overlap); O31213|EFTS_STRCO|TSF|SC2E1.42 from Streptomyces coelicolor (278 aa), FASTA scores: opt: 927, E(): 1.3e-49,(56.3% identity in 277 aa overlap); P80700|EFTS_BACSU|TSF from Bacillus subtilis (292 aa), FASTA scores: opt: 650,E(): 1.3e-32, (43.85% identity in 276 aa overlap); etc. Contains PS01127 Elongation factor Ts signature 2. BELONGS TO THE EF-TS FAMILY.	X2BMB3,Q7TXN0	No									X2BMB3,Q7TXN0	Q7TXN0									
NC_002945.3	Mycobrowser_v4	CDS	3155635	3156498	.	-	0	Mb2914c	rpsB		30s ribosomal protein s2 rpsb	Mb2914c, rpsB, len: 287 aa. Equivalent to Rv2890c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 287 aa overlap). Probable rpsB, 30s ribosomal protein s2, equivalent to O33038|RS2_MYCLE|RPSB|ML1598|MLCB250.63 30S RIBOSOMAL PROTEIN S2 from Mycobacterium leprae (277 aa), FASTA scores: opt: 1593, E(): 2.3e-93, (91.5% identity in 270 aa overlap). Also highly similar to others e.g. O31212|RS2_STRCO|RPSB|SC2E1.41 from Streptomyces coelicolor (310 aa), FASTA scores: opt: 1302, E(): 6.1e-75, (70.6% identity in 289 aa overlap); Q9KA63|RPSB|BH2427 from Bacillus halodurans (244 aa),FASTA scores: opt: 991, E(): 2.3e-55, (59.6% identity in 255 aa overlap); P21464|RS2_BACSU|RPSB from Bacillus subtilis (245 aa), FASTA scores: opt: 959, E(): 2.4e-53,(58.55% identity in 246 aa overlap); etc. Contains PS00962 Ribosomal protein S2 signature 1. BELONGS TO THE S2P FAMILY OF RIBOSOMAL PROTEINS.	X2BMP8,P66538	No									X2BMP8,P66538	P66538									
NC_002945.3	Mycobrowser_v4	CDS	3157310	3158536	.	-	0	Mb2916c	PPE45		ppe family protein ppe45	Mb2916c, PPE45, len: 408 aa. Equivalent to Rv2892c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O06386|Rv3621c|MTCY15C10.31|MTCY07H7B.01 from M. tuberculosis (413 aa), FASTA scores: opt: 957, E(): 6.2e-46, (44.7% identity in 423 aa overlap).	X2BM47,P0A695	No									X2BM47,P0A695	P0A695									
NC_002945.3	Mycobrowser_v4	CDS	3159910	3160806	.	-	0	Mb2918c	xerC		PROBABLE INTEGRASE/RECOMBINASE XERC	Mb2918c, xerC, len: 298 aa. Equivalent to Rv2894c,len: 298 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 298 aa overlap). Probable xerC,integrase/recombinase, equivalent to Q9CBU0|XERC|ML1600|MLCB250.62 INTEGRASE/RECOMBINASE from Mycobacterium leprae (297 aa), FASTA scores: opt: 1624,E(): 2e-97, (85.15% identity in 296 aa overlap). Also highly similar to others integrases/recombinases (generally xerC and xerD) e.g. Q9HTS4|SSS|PA5280 SITE-SPECIFIC RECOMBINASE from Pseudomonas aeruginosa (303 aa), FASTA scores: opt: 660, E(): 3.2e-35, (41.8% identity in 299 aa overlap); Q9HXQ6|XERD|PA3738 INTEGRASE/RECOMBINASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 656, E(): 5.7e-35, (40.05% identity in 297 aa overlap); Q9KCP0|BH1529 INTEGRASE/RECOMBINASE from Bacillus halodurans (299 aa),FASTA scores: opt: 645, E(): 2.9e-34, (37.35% identity in 300 aa overlap); etc. Also similar to O33200|Rv1701|MTCI125.23 INTEGRASE/RECOMBINASE from Mycobacterium tuberculosis (311 aa), FASTA scores: opt: 646, E(): 2.6e-34, (43.1% identity in 304 aa overlap). BELONGS TO THE 'PHAGE' INTEGRASE FAMILY.	X2BMB9,P67629	No									X2BMB9,P67629	P67629									
NC_002945.3	Mycobrowser_v4	CDS	3160897	3161748	.	-	0	Mb2919c	viuB		POSSIBLE MYCOBACTIN UTILIZATION PROTEIN VIUB	Mb2919c, viuB, len: 283 aa. Equivalent to Rv2895c,len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Possible viuB,mycobactin utilization protein, highly similar to Q9RJ78|SCI41.06 HYPOTHETICAL 31.5 KDA PROTEIN from Streptomyces coelicolor (280 aa), FASTA scores: opt: 639,E(): 5.1e-32, (46.3% identity in 285 aa overlap); and similar to other proteins e.g. Q9F641|MXCB protein of the biosynthetic gene cluster of the myxochelin-type iron chelator from Stigmatella aurantiaca (270 aa), FASTA scores: opt: 417, E(): 2.2e-18, (34.2% identity in 263 aa overlap); Q56646|VIUB_VIBCH|VC2210 VIBRIOBACTIN UTILIZATION PROTEIN from Vibrio cholerae (271 aa), FASTA scores: opt: 395, E(): 5.1e-17, (31.0% identity in 274 aa overlap); Q56743|VIUB_VIBVU VULNIBACTIN UTILIZATION PROTEIN V from Vibrio vulnificus (271 aa), FASTA scores: opt: 390, E(): 1e-16, (33.95% identity in 274 aa overlap); etc. Equivalent to AAK47289 from Mycobacterium tuberculosis strain CDC1551 (321 aa) but shorter 38 aa.	X2BMQ4,P65050	No									X2BMQ4,P65050	P65050									
NC_002945.3	Mycobrowser_v4	CDS	3187254	3187592	.	-	0	Mb2943c	glnB		PROBABLE NITROGEN REGULATORY PROTEIN P-II GLNB	Mb2943c, glnB, len: 112 aa. Equivalent to Rv2919c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Probable glnB,nitrogen regulatory protein, highly similar to others e.g. Q9X705|GLNB PII PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (112 aa), FASTA scores: opt: 531,E(): 4.5e-30, (68.75% identity in 112 aa overlap); P21193|GLNB_AZOBR NITROGEN REGULATORY PROTEIN P-II from Azospirillum brasilense (112 aa), FASTA scores: opt: 496,E(): 1.2e-27, (60.7% identity in 112 aa overlap); P05826|GLNB_ECOLI|B2553|Z3829|ECS3419|STY2808 NITROGEN REGULATORY PROTEIN P-II from Escherichia coli strains K12 and O157:H7 (112 aa), FASTA scores: opt: 487, E(): 5.3e-27, (61.6% identity in 112 aa overlap); etc. Contains PS00496 P-II protein urydylation site. BELONGS TO THE P(II) PROTEIN FAMILY.	X2BMG6,P64250	No									X2BMG6,P64250	P64250									
NC_002945.3	Mycobrowser_v4	CDS	3165092	3165922	.	-	0	Mb2923c	fdhD		possible fdhd protein homolog	Mb2923c, fdhD, len: 276 aa. Equivalent to Rv2899c,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Possible fdhD protein, highly similar to other bacterial fdhd proteins e.g. Q9ZBW0|FDHD_STRCO|SC4B5.08c from Streptomyces coelicolor (282 aa), FASTA scores: opt: 1032, E(): 3.6e-59, (59.0% identity in 278 aa overlap); BAB59387|TVG0258796 from Thermoplasma volcanium (279 aa),FASTA scores: opt: 536, E(): 3.4e-27, (38.65% identity in 282 aa overlap); Q9HL17|FDHD_THEAC|TA0423 from Thermoplasma acidophilum (282 aa), FASTA scores: opt: 529,E(): 9.6e-27, (38.8% identity in 281 aa overlap); P32177|FDHD_ECOLI FDHD PROTEIN from Escherichia coli strain K12 (277 aa), FASTA scores: opt: 297, E(): 8.6e-12,(33.35% identity in 261 aa overlap); etc. BELONGS TO THE FDHD FAMILY.	X2BMC9,P64119	No									X2BMC9,P64119	P64119									
NC_002945.3	Mycobrowser_v4	CDS	3165922	3168261	.	-	0	Mb2924c	fdhF		POSSIBLE FORMATE DEHYDROGENASE H FDHF (FORMATE-HYDROGEN-LYASE-LINKED, SELENOCYSTEINE-CONTAINING POLYPEPTIDE) (FORMATE DEHYDROGENASE-H ALPHA SUBUNIT) (FDH-H)	Mb2924c, fdhF, len: 779 aa. Equivalent to Rv2900c,len: 779 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 779 aa overlap). Possible fdhF,formate dehydrogenase (EC 1.2.1.2), highly similar to others formate dehydrogenases and prokaryotic molybdopterin-containing oxidoreductases e.g. Q9S2J9|SC7H2.18 PUTATIVE FORMATE DEHYDROGENASE from Streptomyces coelicolor (759 aa), FASTA scores: opt: 3038,E(): 2.7e-180, (59.7% identity in 767 aa overlap); Q9HU08|PA5181 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (773 aa), FASTA scores: opt: 2560, E(): 1.1e-150, (53.2% identity in 761 aa overlap); P78160 FORMATE DEHYDROGENASE A CHAIN (EC 1.2.1.2) (FRAGMENT) from Escherichia coli strain K12 (740 aa), FASTA scores: opt: 2002, E(): 3.7e-116, (43.1% identity in 733 aa overlap); P07658|FDHF_ECOLI|P78137|B4079 FORMATE DEHYDROGENASE from Escherichia coli strain K12 (715 aa), FASTA scores: opt: 305, E(): 5.6e-13, (25.5% identity in 748 aa overlap); etc. BELONGS TO THE PROKARYOTIC MOLYBDOPTERIN-CONTAINING OXIDOREDUCTASE FAMILY.	X2BMQ9,P65409	No									X2BMQ9,P65409	P65409									
NC_002945.3	Mycobrowser_v4	CDS	3168678	3169472	.	-	0	Mb2926c	rnhB		PROBABLE RIBONUCLEASE HII PROTEIN RNHB (RNASE HII)	Mb2926c, rnhB, len: 264 aa. Equivalent to Rv2902c,len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 264 aa overlap). Probable rnhB,ribonuclease HII (EC 3.1.26.4), equivalent to O33022|RNH2_MYCLE|RNHB|ML1611|MLCB250.40 RIBONUCLEASE HII from Mycobacterium leprae (240 aa), FASTA scores: opt: 1242, E(): 6.9e-72, (76.75% identity in 245 aa overlap). Also similar (but longer ~20 aa) to others e.g. Q9HXY9|RNHB|PA3642 RIBONUCLEASE HII from Pseudomonas aeruginosa (201 aa), FASTA scores: opt: 572, E(): 3.1e-29,(52.7% identity in 184 aa overlap); Q9PEI7|RNH2_XYLFA|RNHB|XF1041 RIBONUCLEASE HII from Xylella fastidiosa (234 aa), FASTA scores: opt: 556, E(): 3.6e-28, (50.25% identity in 185 aa overlap); P10442|RNH2_ECOLI|RNHB|B0183 RIBONUCLEASE HII from Escherichia coli strain K-12 (213 aa), FASTA scores: opt: 519, E(): 7.4e-26, (48.65% identity in 183 aa overlap); etc. BELONGS TO THE RNASE HII FAMILY. COFACTOR: MANGANESE (BY SIMILARITY).	X2BM53,Q7TXM7	No									X2BM53,Q7TXM7	Q7TXM7									
NC_002945.3	Mycobrowser_v4	CDS	3171144	3172088	.	+	0	Mb2929	lppW		PROBABLE CONSERVED ALANINE RICH LIPOPROTEIN LPPW	Mb2929, lppW, len: 314 aa. Equivalent to Rv2905,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). Probable lppW,conserved ala-rich lipoprotein, with slight similarity to beta-lactamases and hypothetical proteins e.g. Q9S1P7|SCJ9A.23 HYPOTHETICAL 36.3 KDA PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 222,E(): 2.8e-06, (25.5% identity in 298 aa overlap); O69914|SC3C8.01 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (302 aa), FASTA scores: opt: 201,E(): 5.1e-05, (24.9% identity in 257 aa overlap); P14559|BLAC_STRAL BETA-LACTAMASE PRECURSOR from Streptomyces albus G (314 aa), FASTA scores: opt: 113,E(): 3.3, (25.2% identity in 278 aa overlap); etc. Has signal peptide and appropriately positioned prokaryotic lipoprotein lipid attachment site: ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR (POTENTIAL).	X2BMR5,P65305	No	cell wall and cell processes								X2BMR5,P65305	P65305				Rv2905		Rv2905			
NC_002945.3	Mycobrowser_v4	CDS	3169486	3170370	.	-	0	Mb2927c	lepB		PROBABLE SIGNAL PEPTIDASE I LEPB (SPASE I) (LEADER PEPTIDASE I).	Mb2927c, lepB, len: 294 aa. Equivalent to Rv2903c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 294 aa overlap). Probable lepB, signal peptidase I (EC 3.4.21.89) (TYPE II MEMBRANE PROTEIN) (see first citation below), equivalent to O33021|LEP_MYCLE|ML1612|MLCB250.39 PROBABLE SIGNAL PEPTIDASE I from Mycobacterium leprae (289 aa), FASTA scores: opt: 1335, E(): 1.8e-77, (69.75% identity in 301 aa overlap). Also similar to many e.g. O86869|SIPX SIGNAL PEPTIDASE I from Streptomyces lividans (320 aa), FASTA scores: opt: 474, E(): 1e-22, (43.55% identity in 248 aa overlap); O69884|SIP1|SIPW PUTATIVE SIGNAL PEPTIDASE I from Streptomyces coelicolor and Streptomyces lividans (259 aa), FASTA scores: opt: 226, E(): 5e-07, (36.0% identity in 214 aa overlap); P42668|LEP_BACLI|SIP SIGNAL PEPTIDASE I from Bacillus licheniformis (186 aa), FASTA scores: opt: 218, E(): 1.3e-06, (34.5% identity in 194 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site,and PS00761 Signal peptidases I signature 3. BELONGS TO PEPTIDASE FAMILY S26; ALSO KNOWN AS TYPE I LEADER PEPTIDASE FAMILY.	Q7TXM6	No								IPR000223,IPR015927,IPR019533,IPR019756,IPR019758,IPR019759,IPR028360	Q7TXM6	A0A1R3Y2Y2									
NC_002945.3	Mycobrowser_v4	CDS	3172181	3172873	.	-	0	Mb2930c	trmD		PROBABLE TRNA (GUANINE-N1)-METHYLTRANSFERASE TRMD (M1G-METHYLTRANSFERASE) (TRNA [GM37] METHYLTRANSFERASE)	Mb2930c, trmD, len: 230 aa. Equivalent to Rv2906c,len: 230 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 230 aa overlap). Probable trmD, tRNA m1G methyltransferase (EC 2.1.1.31), equivalent to O33017|TRMD_MYCLE from Mycobacterium leprae (238 aa),FASTA scores: opt: 1363, E(): 8.1e-86, (87.2% identity in 227 aa overlap). Also highly similar to others e.g. O69882|TRMD_STRCO from Streptomyces coelicolor and S. lividans (277 aa), FASTA scores: opt: 841, E(): 4.5e-50,(55.55% identity in 234 aa overlap); Q9A0B6 from Streptococcus pyogenes (243 aa), FASTA scores: opt: 698,E(): 2.5e-40, (47.6% identity in 227 aa overlap); P07020|TRMD_ECOLI|TRMD|B2607|Z3901|ECS3470 from Escherichia coli strain O157:H7 (255 aa), FASTA scores: opt: 573, E(): 3.8e-33, (42.1% identity in 228 aa overlap); etc. BELONGS TO THE RNA METHYLTRANSFERASE TRMD FAMILY.	X2BLV2,P66969	No									X2BLV2,P66969	P66969									
NC_002945.3	Mycobrowser_v4	CDS	3170428	3170769	.	-	0	Mb2928c	rplS		50s ribosomal protein l19 rpls	Mb2928c, rplS, len: 113 aa. Equivalent to Rv2904c,len: 113 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 113 aa overlap). Probable rplS, 50S ribosomal protein L19, equivalent to O33020|RL19_MYCLE 50S RIBOSOMAL PROTEIN L19 from Mycobacterium leprae (113 aa),FASTA scores: opt: 702, E(): 1.4e-45, (93.8% identity in 113 aa overlap). Also highly similar to others e.g. O69883|RL19_STRCO from Streptomyces coelicolor (116 aa),FASTA scores: opt: 571, E(): 9.5e-36, (77.25% identity in 110 aa overlap); O31742|RL19_BACSU from Bacillus subtilis (115 aa), FASTA scores: opt: 523, E(): 3.8e-32, (72.9% identity in 107 aa overlap); RL19_BACST|P30529 from Bacillus stearothermophilus (116 aa), FASTA scores: opt: 518, E(): 9.1e-32, (71.7% identity in 106 aa overlap); etc. BELONGS TO THE L19P FAMILY OF RIBOSOMAL PROTEINS.	X2BMD7,P66081	No									X2BMD7,P66081	P66081									
NC_002945.3	Mycobrowser_v4	CDS	3172877	3173407	.	-	0	Mb2931c	rimM		PROBABLE 16S RRNA PROCESSING PROTEIN RIMM	Mb2931c, rimM, len: 176 aa. Equivalent to Rv2907c,len: 176 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 176 aa overlap). Probable rimM, 16S rRNA processing protein, equivalent to O33016|RIMM_MYCLE PROBABLE 16S RRNA PROCESSING protein from Mycobacterium leprae (179 aa), FASTA scores: opt: 797, E(): 2.4e-46,(73.15% identity in 175 aa overlap). Also highly similar to others e.g. O69881|RIMM_STRCO from Streptomyces coelicolor (188 aa), FASTA scores: opt: 485, E(): 2.3e-25,(48.85% identity in 176 aa overlap); Q9KA14|RIMM_BACHD from Bacillus halodurans (173 aa), FASTA scores: opt: 289,E(): 3.2e-12, (30.65% identity in 173 aa overlap); P21504|RIMM_ECOLI|RIMM|B2608 from Escherichia coli strain K12 (182 aa), FASTA scores: opt: 237, E(): 1e-08, (29.4% identity in 177 aa overlap). BELONGS TO THE RIMM FAMILY.	X2BM56,P66654	No									X2BM56,P66654	P66654									
NC_002945.3	Mycobrowser_v4	CDS	3173671	3174159	.	-	0	Mb2933c	rpsP		30s ribosomal protein s16 rpsp	Mb2933c, rpsP, len: 162 aa. Equivalent to Rv2909c,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). Probable rpsP, 30S ribosomal protein S16, equivalent to O33014|RS16_MYCLE 30S RIBOSOMAL PROTEIN S16 from Mycobacterium leprae (160 aa),FASTA scores: opt: 828, E(): 1.6e-39, (82.5% identity in 160 aa overlap). Also highly similar to others e.g. O69879|RS16_STRCO 30S RIBOSOMAL PROTEIN S16 from Streptomyces coelicolor (139 aa), FASTA scores: opt: 486,E(): 1.9e-20, (56.95% identity in 144 aa overlap); P80379|RS16_THETH 30S RIBOSOMAL PROTEIN S16 from Thermus Thermophilus (88 aa), FASTA scores: opt: 280, E(): 4.8e-09, (53.25% identity in 77 aa overlap) (C-terminus shorter); P21474|RS16_BACSU|RPSP 30S RIBOSOMAL PROTEIN S16 (BS17) from Bacillus subtilis (89 aa,), FASTA scores: opt: 258, E(): 8.2e-08, (42.85% identity in 91 aa overlap) (C-terminus shorter); etc. BELONGS TO THE S16P FAMILY OF RIBOSOMAL PROTEINS.	X2BME7,P66436	No									X2BME7,P66436	P66436									
NC_002945.3	Mycobrowser_v4	CDS	3174855	3175730	.	+	0	Mb2935	dacB2		probable penicillin-binding protein dacb2 (d-alanyl-d-alanine carboxypeptidase) (dd-peptidase) (dd-carboxypeptidase) (pbp) (dd-transpeptidase) (serine-type d-ala-d-ala carboxypeptidase) (d-amino acid hydrolase)	Mb2935, dacB2, len: 291 aa. Equivalent to Rv2911,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Probable dacB2,D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), an ala-rich protein. Highly similar (except in N-terminus) to Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 749, E(): 9.3e-39,(46.75% identity in 276 aa overlap). Also similar to penicillin binding proteins / D-alanyl-D-alanine carboxypeptidases e.g. Q9KCJ8|SC4G1.16c D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (382 aa),FASTA scores: opt: 386, E(): 2.1e-16, (31.25% identity in 285 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR from Bacillus subtilis (382 aa),FASTA scores: opt: 384, E(): 3.6e-17, (30.7% identity in 244 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN 5) from Bacillus halodurans (395 aa), FASTA scores: opt: 359, E(): 9.7e-15, (30.3% identity in 241 aa overlap); P33364|PBP7_ECOLI|PBPG|B2134 penicillin-binding protein 7 precursor from Escherichia coli strain K12 (313 aa), FASTA scores: opt: 273, E(): 7.5e-10, (27.8% identity in 263 aa overlap); etc. Also similar to O53380|Rv3330|MTV016.30 PENICILLIN-BINDING PROTEIN from Mycobacterium tuberculosis (405 aa), FASTA scores: opt: 746, E(): 1.4e-38, (47.0% identity in 266 aa overlap). Seems to contain PF00768 Peptidase_S11 domain PFAM. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY. Thought to be a membrane-bound protein. Note that previously known as dacB.	Q7TXM5	No								IPR001967,IPR012338,IPR018044	Q7TXM5	A0A1R3Y3C8									
NC_002945.3	Mycobrowser_v4	CDS	3218821	3224304	.	+	0	Mb2959	ppsD		PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Mb2959, ppsD, len: 1827 aa. Equivalent to Rv2934,len: 1827 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1827 aa overlap). ppsD, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9CB70|ML2354 POLYKETIDE SYNTHASE (1822 aa), FASTA scores: opt: 9779,E(): 0, (80.35% identity in 1836 aa overlap); Q49940|L518_F3_67|PFSE (1815 aa), FASTA scores: opt: 9658,E(): 0, (79.85% identity in 1831 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9RNB2|MCYD|Q9FDU1 POLYKETIDE SYNTHASE (MCYD PROTEIN) from Microcystis aeruginosa (3906 aa), FASTA scores: opt: 2961, E(): 6e-159, (32.15% identity in 1827 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1538 aa),FASTA scores: opt: 3756, E(): 3.8e-204, (42.85% identity in 1808 aa overlap) (gaps in middle); P96202|PPSC|RV2933 POLYKETIDE SYNTHASE (2188 aa), FASTA scores: opt: 3463,E(): 1.7e-187, (39.2% identity in 2165 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site,PS00017 ATP/GTP-binding site motif A, PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS00012 Phosphopantetheine attachment site. Note that Rv2934|ppsD belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	X2BMU6,Q7TXL7	No									X2BMU6,Q7TXL7	Q7TXL7									
NC_002945.3	Mycobrowser_v4	CDS	3178283	3180040	.	-	0	Mb2938c	pknI		PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKNI (PROTEIN KINASE I) (STPK I) (PHOSPHORYLASE B KINASE KINASE) (HYDROXYALKYL-PROTEIN KINASE)	Mb2938c, pknI, len: 585 aa. Equivalent to Rv2914c,len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 585 aa overlap). Probable pknI,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), ala-rich protein, highly similar to many in Mycobacterium tuberculosis and other bacteria e.g. Q9RLQ7|MBK PUTATIVE SERINE/THREONINE PROTEIN KINASE from Mycobacterium bovis BCG (291 aa), FASTA scores: opt: 376,E(): 1.1e-10, (36.95% identity in 287 aa overlap); P33973|PKN1_MYXXA serine/threonine-protein kinase from Myxococcus xanthus (693 aa), FASTA scores: opt: 286, E(): 5.4e-10, (29.9% identity in 374 aa overlap); P72003|PKNF_MYCTU|Rv1746|MT1788|MTCY28.09 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis (476 aa), FASTA scores: opt: 675, E(): 1.7e-24, (39.75% identity in 468 aa overlap); Q10697|PKNJ_MYCTU|Rv2088|MT2149|MTCY49.28 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis (589 aa), FASTA scores: opt: 574, E(): 1e-19,(34.85% identity in 479 aa overlap); etc. Equivalent to AAK47308 from Mycobacterium tuberculosis strain CDC1551 (603 aa) but shorter 18 aa. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.	X2BMF5,P65731	No									X2BMF5,P65731	P65731									
NC_002945.3	Mycobrowser_v4	CDS	3196402	3197124	.	-	0	Mb2950c	rnc		PROBABLE RIBONUCLEASE III RNC (RNASE III)	Mb2950c, rnc, len: 240 aa. Equivalent to Rv2925c,len: 240 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 240 aa overlap). Probable rnc,ribonuclease III (RNase III) (EC 3.1.26.3), equivalent to O69469|RNC_MYCLE RIBONUCLEASE III from Mycobacterium leprae (238 aa). Also highly similar to other ribonucleases III e.g. Q9ZBQ7|RNC_STRCO from Streptomyces coelicolor (272 aa), FASTA scores: opt: 889, E(): 5.4e-51,(62.2% identity in 225 aa overlap) (N-terminus longer 21 aa); P51833|RNC_BACSU from Bacillus subtilis (249 aa),FASTA scores: opt: 493, E(): 5e-25, (43.25% identity in 215 aa overlap); P05797|RNC_ECOLI|RNC|B2567|Z3848|ECS3433 from Escherichia coli strain O157:H7 and K12 (226 aa),FASTA scores: opt: 459, E(): 7.9e-23, (41.8% identity in 213 aa overlap); etc. Contains PS00517 Ribonuclease III family signature.	X2BLW8,P66667	No									X2BLW8,P66667	P66667									
NC_002945.3	Mycobrowser_v4	CDS	3181224	3182801	.	-	0	Mb2940c	ffh		probable signal recognition particle protein ffh (fifty-four homolog) (srp protein)	Mb2940c, ffh, len: 525 aa. Equivalent to Rv2916c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable ffh, signal recognition particle protein (ala-, gly-, leu-rich protein), equivalent to O33013|SR54_MYCLE SIGNAL RECOGNITION PARTICLE from Mycobacterium leprae (521 aa),FASTA scores: opt: 2968, E(): 1.6e-145, (87.85% identity in 526 aa overlap). Also highly similar to others e.g. O69874|FFH from Streptomyces coelicolor (550 aa), FASTA scores: opt: 2025, E(): 6e-97, (63.8% identity in 519 aa overlap) (N-terminus longer 34 aa); P37105|SR54_BACSU from Bacillus subtilis (446 aa), FASTA scores: opt: 1451, E(): 1.9e-67, (51.5% identity in 435 aa overlap); BAB57399|FFH from Staphylococcus aureus subsp. aureus Mu50 (455 aa),FASTA scores: opt: 1418, E(): 9.4e-66, (48.65% identity in 448 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SRP FAMILY OF GTP-BINDING PROTEINS. NOTE THAT SIGNAL RECOGNITION PARTICLE CONSISTS OF A SMALL CYTOPLASMIC RNA (SC-RNA) MOLECULE AND PROTEIN FFH. THE PROTEIN HAS A TWO DOMAIN STRUCTURE: THE G-DOMAIN BINDS GTP; THE M-DOMAIN BINDS THE RNA AND ALSO BINDS THE SIGNAL SEQUENCE.	X2BLW0,P66845	No									X2BLW0,P66845	P66845									
NC_002945.3	Mycobrowser_v4	CDS	3184770	3187196	.	-	0	Mb2942c	glnD		PROBABLE [PROTEIN-PII] URIDYLYLTRANSFERASE GLND (PII URIDYLYL-TRANSFERASE) (URIDYLYL REMOVING ENZYME) (UTASE)	Mb2942c, glnD, len: 808 aa. Equivalent to Rv2918c,len: 808 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 808 aa overlap). Probable glnD,uridylyltransferase (ala-rich protein) (EC 2.7.7.59),similar to other uridylyltransferases e.g. O69873||SC2E1.02 from Streptomyces coelicolor (835 aa),FASTA scores: opt: 1473, E(): 2.8e-81, (41.03% identity in 858 aa overlap); P43919|GLND_HAEIN from Haemophilus influenzae (863 aa), FASTA scores: opt: 333, E(): 2.5e-12,(25.4% identity in 819 aa overlap); P27249|GLND_ECOLI|GLND|B0167 from Escherichia coli strain K12 (890 aa), FASTA scores: opt: 306, E(): 1.1e-10,(27.75% identity in 858 aa overlap); etc. BELONGS TO THE GLND FAMILY.	Q7TXM3	No								IPR002912,IPR003607,IPR006674,IPR010043,IPR013546	Q7TXM3	A0A1R3Y2L8									
NC_002945.3	Mycobrowser_v4	CDS	3187589	3189022	.	-	0	Mb2944c	amt		PROBABLE AMMONIUM-TRANSPORT INTEGRAL MEMBRANE PROTEIN AMT	Mb2944c, amt, len: 477 aa. Equivalent to Rv2920c,len: 477 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 477 aa overlap). Probable amt,ammonium-transport integral membrane protein (ala-, gly-,leu-, val-rich protein), highly similar to others e.g. Q9ZBP6|SC7A1.27 AMMONIUM TRANSPORTER from Streptomyces coelicolor (448 aa), FASTA scores: opt: 1246, E(): 7.3e-67, (54.1% identity in 462 aa overlap); P54146|AMT_CORGL AMMONIUM TRANSPORT SYSTEM from Corynebacterium glutamicum (452 aa), FASTA scores: opt: 953, E(): 2.1e-49, (41.45% identity in 475 aa overlap); Q07429|NRGA_BACSU PROBABLE AMMONIUM TRANSPORTER (MEMBRANE PROTEIN NRGA) from Bacillus subtilis (404 aa), FASTA scores: opt: 721, E(): 0, (44.4% identity in 430 aa overlap); etc. BELONGS TO THE AMT1/MEP/NRGA FAMILY OF AMMONIUM TRANSPORTERS (TC 2.49).	X2BMS9,P63520	No									X2BMS9,P63520	P63520									
NC_002945.3	Mycobrowser_v4	CDS	3189499	3190767	.	-	0	Mb2945c	ftsY		probable cell division protein ftsy (srp receptor) (signal recognition particle receptor)	Mb2945c, ftsY, len: 422 aa. Equivalent to Rv2921c,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Probable ftsY,membrane-associated cell division protein, equivalent to O33010|FTSY_MYCLE CELL DIVISION PROTEIN FTSY HOMOLOG from Mycobacterium leprae (430 aa), FASTA scores: opt: 1760,E(): 1.1e-108, (81.35% identity in 429 aa overlap). Also similar to others e.g. Q9I6C1|FTSY|PA0373 SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY from Pseudomonas aeruginosa (455 aa), FASTA scores: opt: 882, E(): 5.1e-40,(42.08% identity in 385 aa overlap); Q9KVJ6|FTSY CELL DIVISION PROTEIN from Vibrio cholerae (391 aa), FASTA scores: opt: 837, E(): 1.2e-37, (36.3% identity in 394 aa overlap); P10121|FTSY_ECOLI|FTSY|B3464 CELL DIVISION PROTEIN from Escherichia coli strain K12 (497 aa), FASTA scores: opt: 800, E(): 1.3e-35, (39.75% identity in 327 aa overlap); etc. Also similar to Q9ZBP9|SC7A1.24 PUTATIVE PROKARYOTIC DOCKING PROTEIN from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1461, E(): 4.3e-71, (60.3% identity in 423 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00300 SRP54-type proteins GTP-binding domain signature. BELONGS TO THE SRP FAMILY OF GTP-BINDING PROTEINS.	X2BLW3,P66843	No									X2BLW3,P66843	P66843									
NC_002945.3	Mycobrowser_v4	CDS	3662164	3662592	.	-	0	Mb3349c	vapc44		possible toxin vapc44. contains pin domain.	Mb3349c, -, len: 142 aa. Equivalent to Rv3320c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P95023|Rv2530c|MTCY159.26 (139 aa),FASTA scores: opt: 292, E(): 4.8e-14, (41.5% identity in 135 aa overlap); O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 287, E(): 1.1e-13, (41.6% identity in 125 aa overlap); O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 252, E(): 3.3e-11, (37.8% identity in 127 aa overlap); etc.	Q7TWQ9	No	virulence, detoxification, adaptation							IPR002716,IPR006226,IPR022907	Q7TWQ9	A0A1R3Y419				Rv3320c		Rv3320c			
NC_002945.3	Mycobrowser_v4	CDS	3190817	3194434	.	-	0	Mb2946c	smc		PROBABLE CHROMOSOME PARTITION PROTEIN SMC	Mb2946c, smc, len: 1205 aa. Equivalent to Rv2922c,len: 1205 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1205 aa overlap). Probable smc,chromosome partition protein (ala-, arg-, leu-, glu-rich protein, possibly coiled-coil protein) (see * below),equivalent (but longer 84 aa) to Q9CBT5|SMC|ML1629|MLCB250.01 POSSIBLE CELL DIVISION PROTEIN from Mycobacterium leprae (1203 aa), FASTA scores: opt: 5957, E(): 0, (79.15% identity in 1205 aa overlap). Also highly similar to other chromosome segregation proteins e.g. Q9ZBQ2|SC7A1.21 PUTATIVE CHROMOSOME ASSOCIATED PROTEIN from Streptomyces coelicolor (1186 aa),FASTA scores: opt: 2633, E(): 4.1e-120, (53.03% identity in 1205 aa overlap); P51834|SMC_BACSU CHROMOSOME PARTITION PROTEIN from Bacillus subtilis (1186 aa), FASTA scores: opt: 1009, E(): 2.1e-41, (30.75% identity in 1205 aa overlap); Q9CHC9|SMC CHROMOSOME SEGREGATION PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (924 aa), FASTA scores: opt: 996, E(): 7.5e-41, (29.75% identity in 874 aa overlap); etc. Equivalent to AAK47317 from Mycobacterium tuberculosis strain CDC1551 (1205 aa) but longer 84 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SMC FAMILY. N-terminus shortened since first submission. [*Note: Cobbe N., Heck M.M.S.- Phylogenetic analysis of SMC proteins (OCT-2001)].	Q7TXM2	No								IPR003395,IPR010935,IPR011890,IPR024704,IPR027417	Q7TXM2	A0A1R3Y2R1									
NC_002945.3	Mycobrowser_v4	CDS	3194446	3194727	.	-	0	Mb2947c	acyP		PROBABLE ACYLPHOSPHATASE ACYP (ACYLPHOSPHATE PHOSPHOHYDROLASE)	Mb2947c, acyP, len: 93 aa. Equivalent to Rv2922A,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable acyP,acylphosphatase (acylphosphate phosphohydrolase) (EC 3.6.1.7), highly similar to others e.g. Q9ZBQ3|SC7A1.20 PUTATIVE ACYLPHOSPHATASE from Streptomyces coelicolor (93 aa), FASTA scores: opt: 345, E(): 9.5e-19, (58.9% identity in 90 aa overlap); P75877|ACYP_ECOLI|YCCX|B0968|Z1320|ECS1052 PUTATIVE ACYLPHOSPHATASE from Escherichia coli strains K12 and O157:H7 (92 aa), FASTA scores: opt: 220, E(): 2e-09,(44.95% identity in 89 aa overlap); Q9RVU3|DR0929 PUTATIVE ACYLPHOSPHATASE from Deinococcus radiodurans (87 aa),FASTA scores: opt: 193, E(): 2.1e-07, (44.3% identity in 79 aa overlap); etc. BELONGS TO THE ACYLPHOSPHATASE FAMILY.	X2BM09,P69418	No									X2BM09,P69418	P69418									
NC_002945.3	Mycobrowser_v4	CDS	3195229	3196098	.	-	0	Mb2949c	fpg		PROBABLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE FPG (FAPY-DNA GLYCOSYLASE)	Mb2949c, fpg, len: 289 aa. Equivalent to Rv2924c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable fpg (alternate gene name: mutM), formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), equivalent to O69470|FPG_MYCLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium leprae (282 aa), FASTA scores: opt: 1563, E(): 1.3e-96,(80.6% identity in 289 aa overlap). Also highly similar to other formamidopyrimidine-DNA glycosylases e.g. Q9ZBQ6|FPG_STRCO from Streptomyces coelicolor (286 aa),FASTA scores: opt: 1047, E(): 2.9e-62, (57.55% identity in 292 aa overlap); P95744|FPG_SYNEN from Synechococcus elongatus naegeli (284 aa), FASTA scores: opt: 569, E(): 1.9e-30, (37.95% identity in 290 aa overlap); P05523|FPG_ECOLI|MUTM|FPG|B3635 from Escherichia coli strain K12 (269 aa), FASTA scores: opt: 424, E(): 8.2e-21,(33.9% identity in 289 aa overlap); etc. BELONGS TO THE FPG FAMILY. COFACTOR: BINDS 1 ZINC ION.	X2BMT5,P64151	No									X2BMT5,P64151	P64151									
NC_002945.3	Mycobrowser_v4	CDS	3198771	3199556	.	+	0	Mb2953	tesA		PROBABLE THIOESTERASE TESA	Mb2953, tesA, len: 261 aa. Equivalent to Rv2928,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable tesA,thioesterase (EC 3.1.2.-), equivalent to Q9Z5K4|ML2359|MLCB12.04c PUTATIVE THIOESTERASE from Mycobacterium leprae (261 aa), FASTA scores: opt: 1326,E(): 3.7e-80, (73.2% identity in 261 aa overlap). Also similar to others e.g. Q9ZGI1 THIOESTERASE II PIKAV from Streptomyces venezuelae (281 aa), FASTA scores: opt: 535,E(): 6.6e-28, (38.05% identity in 234 aa overlap); Q9L4W2|NYSE thioesterase involved in synthesis of the polyene antifungal antibiotic nystatin from Streptomyces noursei (see citation below) (251 aa), FASTA scores: opt: 523, E(): 3.8e-27, (34.53% identity in 223 aa overlap); Q54145 THIOESTERASE from Streptomyces fradiae (253 aa),FASTA scores: opt: 495, E(): 2.7e-25, (37.85% identity in 230 aa overlap); etc.	X2BMI2,P63461	No	lipid metabolism								X2BMI2,P63461	P63461				Rv2928		Rv2928			
NC_002945.3	Mycobrowser_v4	CDS	3200270	3202021	.	+	0	Mb2955	fadD26		fatty-acid-amp ligase fadd26 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb2955, fadD26, len: 583 aa. Equivalent to Rv2930,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 583 aa overlap). fadD26, fatty-acid-CoA synthetase (EC 6.2.1.-) (see first and third citations below), equivalent to Q9Z5K5|FADD26|ML2358|MLCB12.03c PROBABLE ACYL-CoA SYNTHASE from Mycobacterium leprae (583 aa), FASTA scores: opt: 3026, E(): 9.2e-180, (76.85% identity in 583 aa overlap). Also highly similar to many e.g. Q9CD84|ML0132 PUTATIVE ACYL-CoA SYNTHETASE from Mycobacterium leprae (680 aa), FASTA scores: opt: 2324,E(): 3.2e-136, (61.35% identity in 572 aa overlap); P71495 ACYL-CoA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2304, E(): 5e-135, (59.85% identity in 583 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50586|FD25_MYCTU|RV1521|MTCY19G5.07 PUTATIVE FATTY-ACID--CoA LIGASE (583 aa), FASTA scores: opt: 2188,E(): 7.6e-128, (57.55% identity in 584 aa overlap); etc. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. N-terminus shortened since first submission. Note that Rv2930|fadD26 belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	X2BLX3,Q7TXM1	No									X2BLX3,Q7TXM1	Q7TXM1									
NC_002945.3	Mycobrowser_v4	CDS	3202018	3207648	.	+	0	Mb2956	ppsA		PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Mb2956, ppsA, len: 1876 aa. Equivalent to Rv2931,len: 1876 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 1876 aa overlap). ppsA, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9Z5K6|ML2357|MLCB12.02c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1871 aa), FASTA scores: opt: 7566,E(): 0, (76.1% identity in 1888 aa overlap); Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1540 aa), FASTA scores: opt: 4026,E(): 9.8e-212, (45.7% identity in 1811 aa overlap); Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE SYNTHASE (1446 aa), FASTA scores: opt: 4026, E(): 9.4e-212, (70.6% identity in 885 aa overlap). Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 2592, E(): 5.2e-133, (32.55% identity in 2245 aa overlap); P22367|MSAS_PENPA 6-methylsalicylic acid synthase from Penicillium patulum (Penicillium griseofulvum) (1774 aa), FASTA scores: opt: 2391, E(): 0, (34.2% identity in 1815 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1538 aa),FASTA scores: opt: 4227, E(): 0, (46.8% identity in 1810 aa overlap) (gap in middle); etc. Contains PS00606 Beta-ketoacyl synthases active site, and PS00012 Phosphopantetheine attachment site. Note that Rv2931|ppsA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	X2BM73,Q7TXM0	No									X2BM73,Q7TXM0	Q7TXM0									
NC_002945.3	Mycobrowser_v4	CDS	3212258	3218824	.	+	0	Mb2958	ppsC		PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Mb2958, ppsC, len: 2188 aa. Equivalent to Rv2933,len: 2188 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2188 aa overlap). ppsC, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q49933|PKSD|ML2355|L518_F1_3 PUTATIVE POLYKETIDE SYNTHASE (2201 aa), FASTA scores: opt: 6973, E(): 0, (82.32% identity in 2217 aa overlap); Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE (2118 aa), FASTA scores: opt: 4015, E(): 2.9e-208, (36.6% identity in 2184 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7 POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 3909, E(): 3.6e-202, (40.15% identity in 2220 aa overlap); Q9KIZ7|EPOD EPOD PROTEIN from Polyangium cellulosum (7257 aa), FASTA scores: opt: 3886, E(): 6.2e-201, (40.05% identity in 2220 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. P96291|Rv2940c (2111 aa), FASTA scores: opt: 4204, E(): 0,(39.1% identity in 2176 aa overlap); Q10977|PPSA_MYCTU|RV2931 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FASTA scores: opt: 3793,E(): 2.4e-196, (46.65% identity in 1612 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, and PS00012 Phosphopantetheine attachment site. Note that Rv2933|ppsC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	X2BMJ1,Q7TXL8	No									X2BMJ1,Q7TXL8	Q7TXL8									
NC_002945.3	Mycobrowser_v4	CDS	3224310	3228776	.	+	0	Mb2960	ppsE		PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Mb2960, ppsE, len: 1488 aa. Equivalent to Rv2935,len: 1488 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1488 aa overlap). ppsE, type-I polyketide synthase (see citations below), equivalent to Q49934|PKSF|ML2353|L518_F1_8 PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1489 aa), FASTA scores: opt: 8156, E(): 0, (82.05% identity in 1493 aa overlap). Also similar to polyketide synthases from other bacteria e.g. Q9RAH3|NOSB NOSB PROTEIN from Nostoc sp. GSV224 (1244 aa),FASTA scores: opt: 2438, E(): 8.8e-137, (43.75% identity in 969 aa overlap); Q9KIZ8|EPOC EPOC PROTEIN from Polyangium cellulosum (1832 aa), FASTA scores: opt: 2272,E(): 8.6e-127, (39.95% identity in 1061 aa overlap); O54155|SC3F7.12 POLYKETIDE SYNTHASE from Streptomyces coelicolor (2297 aa), FASTA scores: opt: 1522, E(): 3.6e-82, (36.35% identity in 1057 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2935|ppsE belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	X2BLX7,Q7TXL6	No									X2BLX7,Q7TXL6	Q7TXL6									
NC_002945.3	Mycobrowser_v4	CDS	3228787	3229782	.	+	0	Mb2961	drrA		daunorubicin-dim-transport atp-binding protein abc transporter drra	Mb2961, drrA, len: 331 aa. Equivalent to Rv2936,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 331 aa overlap). Probable drrA,daunorubicin-DIM-transport resistance ATP-binding protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q49938|DRRA|ML2352|L518_F2_43|DRRA PROBABLE DAUNORUBICIN RESISTANCE ATP-BINDING PROTEIN from Mycobacterium leprae (331 aa), FASTA scores: opt: 1842, E(): 4.2e-103, (85.2% identity in 331 aa overlap). Also highly similar to others e.g. Q9XCF7 DRRA from Mycobacterium avium (315 aa), FASTA scores: opt: 1040, E(): 4.7e-55, (54.35% identity in 309 aa overlap); Q9X5J8 DAUNORUBICIN RESISTANCE PROTEIN A from Mycobacterium avium (315 aa), FASTA scores: opt: 1030,E(): 1.9e-54, (53.7% identity in 309 aa overlap); P32010|DRRA_STRPE DAUNORUBICIN RESISTANCE ATP-BINDING PROTEIN from Streptomyces peucetius (330 aa), FASTA scores: opt: 852, E(): 9e-44, (47.15% identity in 318 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that Rv2936|drrA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	Q7TXL5	No	cell wall and cell processes							IPR003439,IPR003593,IPR005894,IPR017871,IPR027417	Q7TXL5	A0A1R3Y2L1				Rv2936		Rv2936			
NC_002945.3	Mycobrowser_v4	CDS	3229779	3230648	.	+	0	Mb2962	drrB		daunorubicin-dim-transport integral membrane protein abc transporter drrb	Mb2962, drrB, len: 289 aa. Equivalent to Rv2937,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable drrB,daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q49935|DRRB|ML2351|L518_F1_9 DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (288 aa), FASTA scores: opt: 1252,E(): 5.3e-72, (64.0% identity in 289 aa overlap). Also similar to others e.g. Q9XCF8 DRRB PROTEIN from Mycobacterium avium (246 aa), FASTA scores: opt: 423, E(): 1.5e-19, (30.85% identity in 243 aa overlap); Q9S6H4 DAUNORUBICIN RESISTANCE PROTEIN B from Mycobacterium avium (246 aa), FASTA scores: opt: 420, E(): 2.3e-19, (30.85% identity in 243 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces peucetius (283 aa), FASTA scores: opt: 242,E(): 4.7e-08, (27.85% identity in 219 aa overlap); etc. Note that Rv293|drrB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	Q7TXL4	No	cell wall and cell processes							IPR000412,IPR004377	Q7TXL4	A0A1R3Y2N5				Rv2937		Rv2937			
NC_002945.3	Mycobrowser_v4	CDS	3230645	3231475	.	+	0	Mb2963	drrC		PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC	Mb2963, drrC, len: 276 aa. Equivalent to Rv2938,len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Probable drrC,daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q9CB71|ML2350 PROBABLE ANTIBIOTIC RESISTANCE MEMBRANE PROTEIN from Mycobacterium leprae (276 aa), FASTA scores: opt: 1434, E(): 1.2e-81, (79.0% identity in 276 aa overlap); and Q49941|DRRC|L518_F3_76 PUTATIVE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (244 aa), FASTA scores: opt: 1194, E(): 8.3e-67, (76.85% identity in 242 aa overlap). Also similar to others e.g. Q9XCF9 DRRC PROTEIN from Mycobacterium avium (263 aa), FASTA scores: opt: 538, E(): 3.7e-26, (32.65% identity in 251 aa overlap); Q9S6H3 DAUNORUBICIN RESISTANCE PROTEIN C from Mycobacterium avium (263 aa), FASTA scores: opt: 533, E(): 7.6e-26, (32.25% identity in 251 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces peucetius (283 aa), FASTA scores: opt: 276,E(): 6.6e-10, (21.07% identity in 261 aa overlap); etc. Note that Rv2938|drrC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	Q7TXL3	No	cell wall and cell processes							IPR000412,IPR004377,IPR005943,IPR013525	Q7TXL3	A0A1R3Y2N4				Rv2938		Rv2938			
NC_002945.3	Mycobrowser_v4	CDS	3231522	3232790	.	+	0	Mb2964	papA5		POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5	Mb2964, papA5, len: 422 aa. Equivalent to Rv2939,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Possible papA5,conserved polyketide synthase (PKS) associated protein (see first citation below), equivalent to Q49939 HYPOTHETICAL 45.6 KDA PROTEIN from Mycobacterium leprae (423 aa), FASTA scores: opt: 2398, E(): 4.5e-144, (84.05% identity in 426 aa overlap); and Q02279|YMA3_MYCBO HYPOTHETICAL 38.1 KDA PROTEIN from Mycobacterium bovis (354 aa), FASTA scores: opt: 2193, E(): 3.6e-131, (97.4% identity in 343 aa overlap). And C-terminus highly similar to to Q9S381 HYPOTHETICAL 5.0 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (44 aa), FASTA scores: opt: 275, E(): 1.4e-10, (88.65% identity in 44 aa overlap). Also similar in part to various synthetases e.g. Q9AE01|RIF20 RIF20 PROTEIN from Amycolatopsis mediterranei (Nocardia mediterranei) (403 aa), FASTA scores: opt: 282, E(): 2.7e-10, (30.3% identity in 393 aa overlap); middle part of Q00869|ESYN1 ENNIATIN SYNTHETASE (FRAGMENT) (N-methyl peptide synthetase) from Fusarium equiseti (3131 aa),FASTA scores: opt: 180, E(): 0.0036, (26.85% identity in 242 aa overlap); N-terminus of Q9FB18 PEPTIDE SYNTHETASE NRPS2-1 from Streptomyces verticillus (2626 aa), FASTA scores: opt: 159, E(): 0.068, (23.65% identity in 351 aa overlap); etc. Note that Rv2939|papA5 belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).	X2BMV2,Q02279	No									X2BMV2,Q02279	Q02279									
NC_002945.3	Mycobrowser_v4	CDS	3232953	3239288	.	-	0	Mb2965c	mas		PROBABLE MULTIFUNCTIONAL MYCOCEROSIC ACID SYNTHASE MEMBRANE-ASSOCIATED MAS	Mb2965c, mas, len: 2111 aa. Equivalent to Rv2940c,len: 2111 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2111 aa overlap). Probable mas,mycocerosic acid synthase membrane associated,multifunctional enzyme (see citations below), almost identical to Q02251|MCAS_MYCBO|MAS MYCOCEROSIC ACID SYNTHASE from Mycobacterium bovis (2110 aa), FASTA scores: opt: 13226, E(): 0, (95.8% identity in 2115 aa overlap) (see first citation below); and equivalent to Q9CD78|MAS|ML0139 PUTATIVE MYCOCEROSIC SYNTHASE from Mycobacterium leprae (2116 aa), FASTA scores: opt: 12142,E(): 0, (87.95% identity in 2119 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE from Mycobacterium leprae (2118 aa), FASTA scores: opt: 8421, E(): 0, (60.8% identity in 2127 aa overlap). Also similar to other synthases e.g. C-terminus of Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 4332, E(): 0,(40.85% identity in 2149 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 POLYKETIDE SYNTHASE (2108 aa), FASTA scores: opt: 5059, E(): 0,(65.9% identity in 2121 aa overlap); etc. Contains several domains, organized in the following order: beta-ketoacyl synthase (PS00606), acyl transferase, dehydratase-enoyl reductase, beta-ketoreductase, acyl carrier protein. Contains PS00012 Phosphopantetheine attachment site.	X2BLY1,Q02251	No									X2BLY1,Q02251	Q02251									
NC_002945.3	Mycobrowser_v4	CDS	3254525	3256642	.	-	0	Mb2972c	fadD22		p-hydroxybenzoyl-amp ligase fadd22	Mb2972c, fadD22, len: 705 aa. Equivalent to Rv2948c, len: 705 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 705 aa overlap). Probable fadD22, fatty-acid-CoA synthetase (EC 6.2.1.-). Highly similar to many e.g. Q9CD82|ML0134 putative acyl-CoA synthetase from Mycobacterium leprae (707 aa),fasta scores: opt: 3554, E(): 6.4e-209, (75.9% identity in 705 aa overlap). Almost identical to G560509|Q50468 PKS002A protein from Mycobacterium tuberculosis (705 aa),fasta scores: opt: 4647, E(): 0, (99.7% identity in 705 aa overlap).	X2BM70,Q7TXK7	No	lipid metabolism								X2BM70,Q7TXK7	Q7TXK7				Rv2948c		Rv2948c			
NC_002945.3	Mycobrowser_v4	CDS	3239908	3241650	.	+	0	Mb2966	fadD28		fatty-acid-amp ligase fadd28 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb2966, fadD28, len: 580 aa. Equivalent to Rv2941,len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 580 aa overlap). fadD28 (alternate gene name: acoas), fatty-acid-CoA synthetase (EC 6.2.1.-) (see citations below), almost identical to P71495 ACYL-COA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 3828, E(): 0, (99.15% identity in 580 aa overlap); and equivalent to Q9CD79|FADD28|ML0138 ACYL-COA SYNTHETASE from Mycobacterium leprae (579 aa), FASTA scores: opt: 3183, E(): 8.8e-186, (81.9% identity in 580 aa overlap). And also highly similar to others Mycobacteria proteins e.g. O07797|FADD23|Rv3826|MTCY409.04c PUTATIVE FATTY-ACID-COA SYNTHETASE from Mycobacterium tuberculosis (584 aa); etc. Contains PS00018 EF-hand calcium-binding domain. Note that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally coupled (proven experimentaly).	X2BM82,Q02278	No									X2BM82,Q02278	Q02278									
NC_002945.3	Mycobrowser_v4	CDS	3241643	3244405	.	+	0	Mb2967	mmpL7		CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL7	Mb2967, mmpL7, len: 920 aa. Equivalent to Rv2942,len: 920 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 920 aa overlap). mmpL7, conserved transmembrane transport protein (see citations below),member of RND superfamily, highly similar to Q9XB10 HYPOTHETICAL 99.5 KDA PROTEIN from Mycobacterium bovis BCG (945 aa), FASTA scores: opt: 488, E(): 4.9e-20, (29.5% identity in 918 aa overlap); and to others from Mycobacteria e.g. O53735|MML4_MYCTU from Mycobacterium tuberculosis (945 aa), FASTA scores: opt: 481, E(): 1.2e-19, (25.9% identity in 922 aa overlap); etc. Also similar to other membrane proteins e.g. O54101|MMLB_STRCO|SC10A5.10c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (847 aa), FASTA scores: opt: 256, E(): 7.2e-07, (25.15% identity in 545 aa overlap); etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, PS00079 Multicopper oxidases signature 1, and PS00044 Bacterial regulatory proteins, lysR family signature. BELONGS TO THE MMPL FAMILY. Note that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally coupled (proven experimentaly).	X2BM63,P65371	No									X2BM63,P65371	P65371									
NC_002945.3	Mycobrowser_v4	CDS	3247197	3247898	.	-	0	Mb2970c	lppX		PROBABLE CONSERVED LIPOPROTEIN LPPX	Mb2970c, lppX, len: 233 aa. Equivalent to Rv2945c,len: 233 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 233 aa overlap). Probable lppX,conserved lipoprotein, equivalent to Q9CD80 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (233 aa), FASTA scores: opt: 1165, E(): 2.1e-65, (76.4% identity in 233 aa overlap); and similar to Q9CCP6|ML0557 from Mycobacterium leprae (238 aa), FASTA scores: opt: 338, E(): 7.4e-14,(30.75% identity in 231 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. P71679|LPRG_MYCTU LIPOPROTEIN (236 aa), FASTA scores: opt: 342, E(): 4.1e-14, (32.05% identity in 231 aa overlap); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and has in its N-terminal a signal peptide. BELONGS TO THE LPPX/LPRAFG FAMILY OF LIPOPROTEINS.	X2BLZ5,P65307	No									X2BLZ5,P65307	P65307									
NC_002945.3	Mycobrowser_v4	CDS	3248190	3254528	.	-	0	Mb2971c	pks1		probable polyketide synthase pks15	Mb2971c, pks1, len: 2112 aa. Equivalent to Rv2947c and Rv2946c, len: 496 aa and 1616 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 488 aa overlap and 99.9% identity in 1616 aa overlap). Rv2947c: Probable pks15, polyketide synthase. Almost identical to G560508|Q50469 PKS002B protein from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 3270, E(): 0,(99.6% identity in 496 a a overlap). Similar to Mycobacterium tuberculosis proteins MTCY338.20|RV2931|PPSA_MYCTU ppsA phenolpthiocerol synthesis (1876 aa) (49.9% identity in 465 aa overlap); MTCY24G1.09|RV2940C|P96291 Putative mas, mycocerosic acid synthase (2111 aa) (50.2% identity in 454 aa overlap); and MTCY22H8.03|RV2382C|P71718 hypothetical protein (444 aa) (47.6% identity in 437 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site. Rv2946c: Probable pks1, polyketide synthase, similar to many e.g. ML035|AL583917|Q9CD81 putative polyketide synthase from Mycobacterium leprae (2103 aa), Fasta scores: opt: 8761,E(): 0, (82.6% identity in 1620 aa overlap); etc. Almost identical in part to G560507|Q50470 PKS002C protein from Mycobacterium tuberculosis (fragment) (950 aa), Fasta scores: opt: 5685, E(): 0, (95.3% identity in 927 aa overlap). Also similar to Mycobacterium tuberculosis polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6% identity in 1632 aa); pks12|Rv2048c|O53490 (4151 aa) (58.0% identity in 1606 aa); pks8|rv1662|O65933 (1602 aa) (59.7% identity in 1144 aa). Contains a PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-g) results in a single product that is more similar to pks1.	X2BMA9,Q7TXK8	No	lipid metabolism								X2BMA9,Q7TXK8	Q7TXK8				Rv2947c		Rv2947c			
NC_002945.3	Mycobrowser_v4	CDS	3257284	3259143	.	-	0	Mb2974c	fadD29		fatty-acid-amp ligase fadd29 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb2974c, fadD29, len: 619 aa. Equivalent to Rv2950c, len: 619 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 619 aa overlap). Probable fadD29, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to various mycobacterial enzymes believed to be involved in polyketide or fatty acid synthesis. Equivalent (but shorter 61 aa) to Q9CD84 from Mycobacterium leprae (680 aa), FASTA scores: opt: 3280, E(): 2.2e-192, (80.15% identity in 620 aa overlap); and highly similar to others from Mycobacterium leprae e.g. Q9Z5K5 PROBABLE ACYL-COA SYNTHASE (583 aa), FASTA scores: opt: 2358, E(): 3.4e-136,(62.35% identity in 579 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. Q10976|FD26_MYCTU PUTATIVE FATTY-ACID--CoA LIGASE (583 aa), FASTA scores: opt: 2416, E(): 1e-139, (63.15% identity in 581 aa overlap) (N-terminus shorter); etc. Equivalent to AAK47349 from Mycobacterium tuberculosis strain CDC1551 (582 aa) but longer 37 aa.	X2BMY4,Q7TXK5	No	lipid metabolism								X2BMY4,Q7TXK5	Q7TXK5				Rv2950c		Rv2950c			
NC_002945.3	Mycobrowser_v4	CDS	3273218	3274150	.	+	0	Mb2988	purU		PROBABLE FORMYLTETRAHYDROFOLATE DEFORMYLASE PURU (FORMYL-FH(4) HYDROLASE)	Mb2988, purU, len: 310 aa. Equivalent to Rv2964,len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 310 aa overlap). Probable purU,formyltetrahydrofolate deformylase (EC 3.5.1.10), highly similar to others e.g. Q9RWT1|DR0584 FORMYLTETRAHYDROFOLATE DEFORMYLASE from Deinococcus radiodurans (298 aa), FASTA scores: opt: 1005, E(): 4.9e-52, (52.25% identity in 297 aa overlap); Q9K7U4 FORMYLTETRAHYDROFOLATE DEFORMYLASE from Bacillus halodurans (289 aa), FASTA scores: opt: 982, E(): 1.1e-50,(51.8% identity in 280 aa overlap); Q55135|PURU_SYNY3|SLL0070 FORMYLTETRAHYDROFOLATE DEFORMYLASE from Synechocystis sp. strain PCC 6803 (284 aa), FASTA scores: opt: 839, E(): 2.9e-42, (48.2% identity in 280 aa overlap); etc.	X2BMP9,P0A5T7	No	intermediary metabolism and respiration								X2BMP9,P0A5T7	P0A5T7				Rv2964		Rv2964			
NC_002945.3	Mycobrowser_v4	CDS	3275019	3275504	.	-	0	Mb2989c	kdtB		PROBABLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE KDTB (PANTETHEINE-PHOSPHATE ADENYLYLTRANSFERASE) (PPAT) (DEPHOSPHO-COA PYROPHOSPHORYLASE)	Mb2989c, kdtB, len: 161 aa. Equivalent to Rv2965c,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). Probable kdtB (alternate gene name: coaD), phosphopantetheine adenylyltransferase (EC 2.7.7.3), equivalent to O69466|COAD_MYCLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE from Mycobacterium leprae (160 aa), FASTA scores: opt: 881, E(): 2.5e-54, (84.1% identity in 157 aa overlap). Also highly similar to others e.g. Q9ZBR1|COAD_STRCO from Streptomyces coelicolor (159 aa), FASTA scores: opt: 575,E(): 5.8e-33, (54.1% identity in 159 aa overlap); Q9WZK0|COAD_THEMA from Thermotoga maritima (161 aa), FASTA scores: opt: 509, E(): 2.4e-28, (50.0% identity in 154 aa overlap); P23875|COAD_ECOLICOAD|KDTB|B3634|Z5058|ECS4509 from Escherichia coli strain O157:H7 and K12 (159 aa),FASTA scores: opt: 459, E(): 7.3e-25, (45.15% identity in 155 aa overlap); etc. BELONGS TO THE COAD FAMILY.	X2BMZ6,P0A531	No									X2BMZ6,P0A531	P0A531									
NC_002945.3	Mycobrowser_v4	CDS	3293365	3294477	.	-	0	Mb3005c	ddlA		PROBABLE D-ALANINE--D-ALANINE LIGASE DDLA (D-ALANYLALANINE SYNTHETASE) (D-ALA-D-ALA LIGASE)	Mb3005c, ddlA, len: 370 aa. Equivalent to Rv2981c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 373 aa overlap). Probable ddlA (alternate gene name: ddl), D-alanine--D-alanine ligase A (EC 6.3.2.4), equivalent to Q9CBS0|Q9CBS0 D-ALANINE-D-ALANINE LIGASE A from Mycobacterium leprae (384 aa), FASTA scores: opt: 2001, E(): 2.4e-115, (81.75% identity in 367 aa overlap); and Q9ZGN0|DDL_MYCSM D-ALANINE--D-ALANINE LIGASE from Mycobacterium smegmatis (373 aa), FASTA scores: opt: 1934, E(): 3.1e-111, (77.95% identity in 372 aa overlap). Also highly similar to others e.g. Q9ZBR9|DDL_STRCO from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1187, E(): 2.2e-65, (52.0% identity in 379 aa overlap); P15051|DDLA_SALTY from Salmonella typhimurium and Salmonella typhi (363 aa),FASTA scores: opt: 946, E(): 1.3e-50, (44.5% identity in 364 aa overlap); P23844|DDLA_ECOLI|DDLA|B0381|Z0477|ECS0431 from Escherichia coli strain O157:H7 and K12 (364 aa), FASTA scores: opt: 938, E(): 3.9e-50, (43.55% identity in 363 aa overlap); etc. Contains PS00843 D-alanine--D-alanine ligase signature 1. BELONGS TO THE D-ALANINE--D-ALANINE LIGASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (acgccggtc-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (370 aa versus 373 aa).	X2BMD9,Q7TXH9	No									X2BMD9,Q7TXH9	Q7TXH9									
NC_002945.3	Mycobrowser_v4	CDS	3281262	3282392	.	-	0	Mb2994c	lipN		PROBABLE LIPASE/ESTERASE LIPN	Mb2994c, lipN, len: 376 aa. Equivalent to Rv2970c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Probable lipN,lipase/esterase (EC 3.1.1.-), similar to others e.g. Q9AA37|CC0771 PUTATIVE ESTERASE from Caulobacter crescentus (380 aa), FASTA scores: opt: 822, E(): 8e-46,(42.15% identity in 318 aa overlap); Q9XDR4 ESTERASE HDE from petroleum-degrading bacterium HD-1 (317 aa), FASTA scores: opt: 738, E(): 2e-40, (48.85% identity in 262 aa overlap); O52270 LIPASE from Pseudomonas sp. (strain B11-1) (308 aa), FASTA scores: opt: 683, E(): 7.3e-37,(41.3% identity in 288 aa overlap); etc. Also similar to P71668 HYPOTHETICAL 34.1 KDA PROTEIN from Mycobacterium tuberculosis (320 aa), FASTA scores: opt: 715, E(): 6.3e-39, (42.3% identity in 298 aa overlap). Equivalent to AAK47374 from Mycobacterium tuberculosis strain CDC1551 (309 aa) but longer 67 aa.	Q7TXI8	No								IPR013094	Q7TXI8	A0A1R3Y2W7									
NC_002945.3	Mycobrowser_v4	CDS	3288758	3289441	.	-	0	Mb3000c	ung		PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG)	Mb3000c, ung, len: 227 aa. Equivalent to Rv2976c,len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 227 aa overlap). Probable ung,uracil-DNA glycosylase (EC 3.2.2.-), equivalent to Q9CBS3 URACIL-DNA GLYCOSYLASE from Mycobacterium leprae (227 aa),FASTA scores: opt: 1394, E(): 8.8e-85, (88.1% identity in 227 aa overlap). Also highly similar to others e.g. Q9EX12 from Streptomyces coelicolor (225 aa), FASTA scores: opt: 1134, E(): 1.3e-67, (72.75% identity in 224 aa overlap); Q9K682|UNG_BACHD from Bacillus halodurans (224 aa), FASTA scores: opt: 652, E(): 8.9e-36, (45.5% identity in 222 aa overlap); P39615|UNG_BACSU from Bacillus subtilis (225 aa), FASTA scores: opt: 625, E(): 5.4e-34, (45.5% identity in 222 aa overlap); etc. BELONGS TO THE URACIL-DNA GLYCOSYLASE FAMILY.	X2BMD5,P67072	No									X2BMD5,P67072										
NC_002945.3	Mycobrowser_v4	CDS	3284422	3286635	.	-	0	Mb2998c	recG		PROBABLE ATP-DEPENDENT DNA HELICASE RECG	Mb2998c, recG, len: 737 aa. Equivalent to Rv2973c,len: 737 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 737 aa overlap). Probable recG,ATP-dependent DNA helicase (EC 3.6.1.-), equivalent to O69460|RECG_MYCLE ATP-DEPENDENT DNA HELICASE from Mycobacterium leprae (743 aa), FASTA scores: opt: 3846,E(): 0, (79.3% identity in 744 aa overlap). Also highly similar to others e.g. Q9ZBR3|SC7A1.10 PUTATIVE ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor (742 aa), FASTA scores: opt: 1249, E(): 1.1e-67, (46.2% identity in 758 aa overlap); Q9PGE8 ATP-DEPENDENT DNA HELICASE from Xylella fastidiosa (718 aa), FASTA scores: opt: 1174, E(): 3.5e-63, (42.1% identity in 539 aa overlap); P24230|RECG_ECOLI|RECG|B3652 from Escherichia coli strain K12 (693 aa), FASTA scores: opt: 457, E(): 7.3e-22, (35.2% identity in 733 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, RECG SUBFAMILY.	X2BMQ8,P64323	No									X2BMQ8,P64323										
NC_002945.3	Mycobrowser_v4	CDS	3321324	3322445	.	+	0	Mb3031	lppZ		PROBABLE CONSERVED LIPOPROTEIN LPPZ	Mb3031, lppZ, len: 373 aa. Equivalent to Rv3006,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 373 aa overlap). Probable lppZ,conserved lipoprotein, equivalent to O33109|MLCB637.17C|ML1699 putative lipoprotein from M. leprae (372 aa), FASTA scores: opt: 2211, E(): 4.3e-100,(87.1% identity in 373 aa overlap). Shows also similarity (in part) with Q9Z571|SC8D9.20c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (447 aa), FASTA scores: opt: 185, E(): 0.051, (31.6% identity in 300 aa overlap); Q9Z9R3|BH2090 GLUCOSE DEHYDROGENASE-B from Bacillus halodurans (371 aa), FASTA scores: opt: 206, E(): 0.0043,(28.3% identity in 205 aa overlap); and other GLUCOSE DEHYDROGENASES B. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, followed by a proline-rich domain.	Q7TXG5	No	cell wall and cell processes							IPR011041,IPR011042,IPR012938	Q7TXG5					Rv3006		Rv3006			
NC_002945.3	Mycobrowser_v4	CDS	3337239	3337553	.	-	0	Mb3048c	PE29		pe family protein pe29	Mb3048c, PE29, len: 104 aa. Equivalent to Rv3022A,len: 104 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 104 aa overlap). Member of the Mycobacterium tuberculosis PE family, similar to many others e.g. Rv0285|AL021930_12 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 497, E(): 3e-21,(80.39% identity in 102 aa overlap); etc.	Q7TXF5	No								IPR000084	Q7TXF5										
NC_002945.3	Mycobrowser_v4	CDS	3289474	3290475	.	-	0	Mb3001c	thiL		PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE)	Mb3001c, thiL, len: 333 aa. Equivalent to Rv2977c,len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 333 aa overlap). Possible thiL,thiamin-monophosphate kinase (EC ), equivalent to Q9CBS2 PROBABLE THIAMINE-MONOPHOSPHATE KINASE from Mycobacterium leprae (325 aa), FASTA scores: opt: 1738, E(): 4.5e-98,(80.9% identity in 314 aa overlap). Also highly similar to others e.g. Q9ZBR7|SC7A1.06 PUTATIVE THIAMINE MONPHOSPHATE KINASE from Streptomyces coelicolor (322 aa), FASTA scores: opt: 959, E(): 7.8e-51, (51.1% identity in 319 aa overlap); O05514|THIL_BACSU THIAMINE-MONOPHOSPHATE KINASE from Bacillus subtilis (325 aa), FASTA scores: opt: 476,E(): 1.5e-21, (35.15% identity in 273 aa overlap); P77785|THIL_ECOLI|THIL|B0417 THIAMINE-MONOPHOSPHATE KINASE from Escherichia coli strain K12 (325 aa), FASTA scores: opt: 418, E(): 5e-18, (36.9% identity in 282 aa overlap); etc. BELONGS TO THE THIAMINE-MONOPHOSPHATE KINASE FAMILY. Note that the start, as given, is in IS1538.	Q7TXI3	No								IPR000728,IPR006283,IPR010918,IPR016188	Q7TXI3										
NC_002945.3	Mycobrowser_v4	CDS	3294555	3295559	.	-	0	Mb3006c	gpdA2		PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA2 (NAD(P)H-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE)	Mb3006c, gpdA2, len: 334 aa. Equivalent to Rv2982c,len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 334 aa overlap). Probable gpdA2 (alternate gene name: gpsA), glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94), equivalent to Q9CBR9|GPDA_MYCLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] from Mycobacterium leprae (349 aa), FASTA scores: opt: 1686, E(): 1.7e-95, (77.95% identity in 349 aa overlap). Also highly similar to others e.g. Q9ZBS0|GPDA_STRCO from Streptomyces coelicolor (336 aa),FASTA scores: opt: 1165, E(): 9.8e-64, (56.25% identity in 327 aa overlap); P46919|GPDA_BACSU from Bacillus subtilis (345 aa), FASTA scores: opt: 872, E(): 7.5e-46, (44.9% identity in 325 aa overlap); P37606|GPDA_ECOLI|GPSA|B3608|Z5035|ECS4486. from Escherichia coli strain O157:H7 and K12 (339 aa), FASTA scores: opt: 799, E(): 2.1e-41, (42.9% identity in 331 aa overlap); etc. Also highly similar to O53761|GPD2_MYCTU PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE from Mycobacterium tuberculosis (341 aa), FASTA scores: opt: 740, E(): 8.4e-38, (40.35% identity in 322 aa overlap). BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY.	X2BM95,P59961	No									X2BM95,P59961										
NC_002945.3	Mycobrowser_v4	CDS	3296414	3298642	.	+	0	Mb3008	ppk		polyphosphate kinase ppk (polyphosphoric acid kinase) (atp-polyphosphate phosphotransferase)	Mb3008, ppk, len: 742 aa. Equivalent to Rv2984,len: 742 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 742 aa overlap). Probable ppk,polyphosphate kinase (EC 2.7.4.1), equivalent to O33127|PPK_MYCLE POLYPHOSPHATE KINASE from Mycobacterium leprae (739 aa), FASTA scores: opt: 4264, E(): 0, (87.85% identity in 742 aa overlap). Also highly similar to others e.g. Q9KZV6|PPK_STRCO from Streptomyces coelicolor (746 aa), FASTA scores: opt: 1979, E(): 2.6e-117, (59.9% identity in 701 aa overlap); Q9KD27|PPK_BACHD from Bacillus halodurans (705 aa), FASTA scores: opt: 1319,E(): 1.4e-75, (45.55% identity in 674 aa overlap); Q9PAC7|PPK_XYLFA from Xylella fastidiosa (698 aa), FASTA scores: opt: 1300, E(): 2.2e-74, (43.3% identity in 693 aa overlap); etc. BELONGS TO THE POLYPHOSPHATE KINASE FAMILY.	X2BN16,P65769	No	intermediary metabolism and respiration								X2BN16,P65769					Rv2984		Rv2984			
NC_002945.3	Mycobrowser_v4	CDS	3301214	3302635	.	-	0	Mb3012c	leuC		PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI)	Mb3012c, leuC, len: 473 aa. Equivalent to Rv2988c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 473 aa overlap). Probable leuC,3-isopropylmalate dehydratase, large subunit (EC 4.2.1.33), equivalent to O33123|LEU2_MYCLE 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT from Mycobacterium leprae (476 aa), FASTA scores: opt: 2818,E(): 1.3e-171, (88.75% identity in 471 aa overlap). Also highly similar to many e.g. Q44427|LEU2_ACTTI from Actinoplanes teichomyceticus (485 aa), FASTA scores: opt: 1958, E(): 6.5e-117, (71.0% identity in 479 aa overlap); P55251|LEU2_RHIPU from Rhizomucor pusillus (755 aa), FASTA scores: opt: 1937, E(): 1.9e-115, (61.25% identity in 467 aa overlap) (C-terminus longer); P30127|LEU2_ECOLI|LEUC|B0072 from Escherichia coli strain K12 (465 aa), FASTA scores: opt: 1896, E(): 5.5e-113,(61.6% identity in 456 aa overlap); etc. Contains PS00450 Aconitase family signature. BELONGS TO THE ACONITASE/IPM ISOMERASE FAMILY. TBparse score is 0.895.	X2BMS1,Q7TXH6	No									X2BMS1,Q7TXH6										
NC_002945.3	Mycobrowser_v4	CDS	3314217	3315182	.	+	0	Mb3024	lppY		PROBABLE CONSERVED LIPOPROTEIN LPPY	Mb3024, lppY, len: 321 aa. Equivalent to Rv2999,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 321 aa overlap). Probable lppY,conserved lipoprotein, highly similar to O07774|LPQO|Rv0604|MTCY19H5.18c PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (316 aa), FASTA scores: opt: 1153, E(): 5e-62, (53.2% identity in 312 aa overlap); and showing similarity with AAK80743|CAC2799 UNCHARACTERIZED CONSERVED PROTEIN SIMILAR TO LPPY/LPQO OF Mycobacterium tuberculosis from Clostridium acetobutylicum (152 aa),FASTA scores: opt: 165, E(): 0.0077, (26.08% identity in 138 aa overlap); and Q9F2T1|SCD65.01c PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (146 aa), FASTA scores: opt: 126, E(): 1.6, (% identity in aa overlap). Equivalent to AAK47407 from Mycobacterium tuberculosis strain CDC1551 (329 aa) but shorter 8 aa. Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TXG8	No	cell wall and cell processes							IPR011094	Q7TXG8					Rv2999		Rv2999			
NC_002945.3	Mycobrowser_v4	CDS	3298725	3299678	.	+	0	Mb3009	mutT1		POSSIBLE HYDROLASE MUTT1	Mb3009, mutT1, len: 317 aa. Equivalent to Rv2985,len: 317 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 317 aa overlap). Possible mutT1, long mutt protein (hydrolase) (EC 3.-.-.-), highly similar to O33126|MLCB637.35 HYPOTHETICAL 34.5 KDA PROTEIN from Mycobacterium leprae (312 aa), FASTA scores: opt: 1514,E(): 5.1e-91, (71.85% identity in 316 aa overlap); and Q9CBR8|ML1682 HYPOTHETICAL PROTEIN from Mycobacterium leprae (311 aa), FASTA scores: opt: 1510, E(): 9.2e-91,(71.5% identity in 316 aa overlap). Also similar to Q50195|L222-ORF6|ML2698 HYPOTHETICAL PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 231,E(): 1.1e-07, (36.7% identity in 128 aa overlap). Also similar to shorter mutt proteins and related hypothetical protein e.g. Q9EUS6 HYPOTHETICAL 16.6 KDA PROTEIN from Streptomyces griseus subsp. griseus (152 aa), FASTA scores: opt: 380, E(): 1.7e-17, (50.75% identity in 130 aa overlap); Q9KZV8|SCD84.10C PUTATIVE MUTT-LIKE PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 376,E(): 2.9e-17, (46.1% identity in 128 aa overlap); P96590|MUTT MUTT PROTEIN from Bacillus subtilis (149 aa),FASTA scores: opt: 180, E(): 0.00017, (35.25% identity in 122 aa overlap); etc. Also similar to O05437 HYPOTHETICAL 27.1 KDA PROTEIN from Mycobacterium tuberculosis (248 aa),FASTA scores: opt: 224, E(): 3.2e-07, (34.03% identity in 144 aa overlap). Contains PS00893 mutT domain signature. SEEMS TO BELONG TO THE MUTT/NUDIX FAMILY PROTEIN.	Q7TXH7	No								IPR000086,IPR013078,IPR015797,IPR020084,IPR020476	Q7TXH7										
NC_002945.3	Mycobrowser_v4	CDS	3299736	3300380	.	-	0	Mb3010c	hupB		dna-binding protein hu homolog hupb (histone-like protein) (hlp) (21-kda laminin-2-binding protein)	Mb3010c, hupB, len: 214 aa. Equivalent to Rv2986c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable hupB (alternate gene names: hup, hlp, lbp21), DNA-binding protein HU homolog (resembles fusion between HU and histone) (see first citation below), equivalent to others from Mycobacteria e.g. Q9XB18|DBH_MYCBO from Mycobacterium bovis (205 aa), FASTA scores: opt: 1050, E(): 5.6e-45,(95.35% identity in 214 aa overlap); Q9ZHC5|DBH_MYCSM from Mycobacterium smegmatis (208 aa), FASTA scores: opt: 1035,E(): 3.1e-44, (80.2% identity in 217 aa overlap); and O33125|DBH_MYCLE from Mycobacterium leprae (200 aa), FASTA scores: opt: 914, E(): 2.7e-38, (80.1% identity in 216 aa overlap). Also highly similar to others from other organisms e.g. O86537|DBH2_STRCO from Streptomyces coelicolor (218 aa), FASTA scores: opt: 569, E(): 2.6e-21,(51.35% identity in 220 aa overlap); P08821|DBH1_BACSU from Bacillus subtilis (92 aa), FASTA scores: opt: 280,E(): 2.5e-07, (45.05% identity in 91 aa overlap) (C-terminus shorter); etc. Contains PS00045 Bacterial histone-like DNA-binding proteins signature. BELONGS TO THE BACTERIAL HISTONE-LIKE PROTEIN FAMILY. Note that its C-terminal domain is very rich in lysine and alanine.	X2BME1,Q9XB18	No									X2BME1,Q9XB18										
NC_002945.3	Mycobrowser_v4	CDS	3300593	3301189	.	-	0	Mb3011c	leuD		PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) LEUD (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI)	Mb3011c, leuD, len: 198 aa. Equivalent to Rv2987c,len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 198 aa overlap). Probable leuD,3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33), equivalent to O33124|LEUD_MYCLE 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT from Mycobacterium leprae (198 aa), FASTA scores: opt: 1155,E(): 4.2e-72, (87.75% identity in 196 aa overlap). Also highly similar to many e.g. O86535|LEUD_STRCO from Streptomyces coelicolor (197 aa), FASTA scores: opt: 765,E(): 2.6e-45, (59.0% identity in 195 aa overlap); P04787|LEUD_SALTY from Salmonella typhimurium (201 aa),FASTA scores: opt: 528, E(): 5.2e-29, (45.05% identity in 191 aa overlap); P30126|LEUD_ECOLI|LEUD|B0071 from Escherichia coli strain K12 (201 aa), FASTA scores: opt: 498, E(): 6e-27, (43.45% identity in 191 aa overlap); etc. TBparse score is 0.939.	X2BM97,P65278	No									X2BM97,P65278										
NC_002945.3	Mycobrowser_v4	CDS	3353018	3353701	.	-	0	Mb3062c	TB22.2		PROBABLE CONSERVED SECRETED PROTEIN TB22.2	Mb3062c, TB22.2, len: 227 aa. Equivalent to Rv3036c, len: 227 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 227 aa overlap). Probable TB22.2, conserved secreted protein, with putative N-terminal signal peptide, highly similar to secreted immunogenic protein MPT64/MPB64 P19996|Rv1980c|MTCY39.39 from Mycobacterium tuberculosis and Mycobacterium bovis (228 aa), FASTA scores: opt: 681, E(): 2.5e-35, (45.8% identity in 227 aa overlap).	Q7TXE4	No	cell wall and cell processes							IPR021729	Q7TXE4					Rv3036c		Rv3036c			
NC_002945.3	Mycobrowser_v4	tRNA	3305107	3305179	.	-	0	gluU	gluU		tRNA-Glu	gluU, len: 73 nt. Equivalent to gluU, len: 73 nt,from Mycobacterrium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Glu; anticodon ctc.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	3305219	3305290	.	-	0	glnU	glnU		tRNA-Gln	glnU, len: 72 nt. Equivalent to glnU, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Gln; anticodon ctg.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3305365	3306837	.	-	0	Mb3016c	gltS		glutamyl-trna synthetase glts (glutamate--trna ligase) (glutamyl-trna synthase) (glurs)	Mb3016c, gltS, len: 490 aa. Equivalent to Rv2992c,len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 490 aa overlap). Probable gltS (alternate gene name: gltX), glutamyl-tRNA synthase (EC 6.1.1.17), equivalent to O33120|SYE_MYCLE GLUTAMYL-TRNA SYNTHETASE from Mycobacterium leprae (502 aa), FASTA scores: opt: 2660, E(): 2.3e-163, (81.35% identity in 488 aa overlap). Also highly similar to others e.g. O86528|SYE_STRCO from Streptomyces coelicolor (494 aa),FASTA scores: opt: 1777, E(): 1.4e-106, (57.45% identity in 484 aa overlap); P22250|SYE_BACSU from Bacillus subtilis (483 aa), FASTA scores: opt: 1099, E(): 5.4e-63,(38.45% identity in 489 aa overlap); O51345|SYE_BORBU|GLTX|BB0372 from Borrelia burgdorferi (Lyme disease spirochete) (490 aa), FASTA scores: opt: 1009, E(): 3.3e-57, (34.85% identity in 491 aa overlap); etc. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. TBparse score is 0.891.	X2BMA1,P0A637	No									X2BMA1,P0A637										
NC_002945.3	Mycobrowser_v4	CDS	3309074	3310084	.	-	0	Mb3019c	leuB		probable 3-isopropylmalate dehydrogenase leub (beta-ipm dehydrogenase) (imdh) (3-ipm-dh)	Mb3019c, leuB, len: 336 aa. Equivalent to Rv2995c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 336 aa overlap). leuB,3-isopropylmalate dehydrogenase (EC 1.1.1.85) (see citation below), identical except one bp to P94929|LEU3_MYCBO 3-ISOPROPYLMALATE DEHYDROGENASE from Mycobacterium bovis (336 aa), FASTA scores: opt: 2168,E(): 5.1e-132, (99.7% identity in 336 aa overlap); and equivalent to O33117|LEU3_MYCLE 3-ISOPROPYLMALATE DEHYDROGENASE from Mycobacterium leprae (336 aa), FASTA scores: opt: 1864, E(): 1.8e-112, (83.95% identity in 336 aa overlap). Also highly similar to others e.g. P94631|LEU3_CORGL from Corynebacterium glutamicum (340 aa), FASTA scores: opt: 1526, E(): 1e-90, (69.9% identity in 339 aa overlap); O86504 from Streptomyces coelicolor (347 aa), FASTA scores: opt: 1470, E(): 4.2e-87, (67.85% identity in 339 aa overlap); Q9UZ05|PAB2424 from Pyrococcus abyssi (354 aa), FASTA scores: opt: 998, E(): 1e-56, (50.0% identity in 322 aa overlap); etc. Note that also shows high similarity with many tartrate dehydrogenases (EC 1.1.1.93). BELONGS TO THE ISOCITRATE AND ISOPROPYLMALATE DEHYDROGENASES FAMILY.	X2BM37,P94929	No									X2BM37,P94929										
NC_002945.3	Mycobrowser_v4	CDS	3310099	3311685	.	-	0	Mb3020c	serA1		PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH)	Mb3020c, serA1, len: 528 aa. Equivalent to Rv2996c,len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 528 aa overlap). Probable serA1,D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95),equivalent to SERA_MYCLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE from Mycobacterium leprae (528 aa), FASTA scores: opt: 2974, E(): 1.9e-166, (89.6% identity in 528 aa overlap). Also highly similar to many e.g. Q9Z564 from Streptomyces coelicolor (529 aa), FASTA scores: opt: 1879,E(): 2.1e-102, (57.6% identity in 526 aa overlap); O29445|SERA_ARCFU from Archaeoglobus fulgidus (527 aa),FASTA scores: opt: 1252, E(): 9.6e-66, (41.3% identity in 530 aa overlap); P35136|SERA_BACSU from Bacillus subtilis (525 aa), FASTA scores: opt: 1172, E(): 4.5e-61, (37.9% identity in 528 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature, and PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. BELONGS TO THE D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASES FAMILY. Note that previously known as serA.	X2BME8,P0A545	No									X2BME8,P0A545										
NC_002945.3	Mycobrowser_v4	CDS	3316200	3317201	.	-	0	Mb3026c	ilvC		PROBABLE KETOL-ACID REDUCTOISOMERASE ILVC (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)	Mb3026c, ilvC, len: 333 aa. Equivalent to Rv3001c,len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 333 aa overlap). Probable ilvC,ketol-acid reductoisomerase (EC 1.1.1.86), equivalent or highly similar to others e.g. Q59500|ILVC_MYCAV from Mycobacterium avium (333 aa), FASTA scores: opt: 1977,E(): 3.2e-113, (87.7% identity in 333 aa overlap); O33114|ILVC_MYCLE from Mycobacterium leprae (333 aa),FASTA scores: opt: 1924, E(): 5.3e-110, (86.5% identity in 333 aa overlap); Q9Z565|ILVC_STRCO|SC8D9.26 from Streptomyces coelicolor (332 aa), FASTA scores: opt: 1494,E(): 8.3e-84, (67.5% identity in 326 aa overlap); Q59818|ILVC_STRAW from Streptomyces avermitilis (333 aa) FASTA scores: opt: 1487, E(): 2.2e-83, (66.8% identity in 326 aa overlap); etc. BELONGS TO THE KETOL-ACID REDUCTOISOMERASES FAMILY.	X2BMA8,P65150	No									X2BMA8,P65150										
NC_002945.3	Mycobrowser_v4	CDS	3317239	3317745	.	-	0	Mb3027c	ilvN		PROBABLE ACETOLACTATE SYNTHASE (SMALL SUBUNIT) ILVN (ACETOHYDROXY-ACID SYNTHASE) (AHAS) (ALS)	Mb3027c, ilvN, len: 168 aa. Equivalent to Rv3002c,len: 168 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 168 aa overlap). Probable ilvN (alternate gene name: ilvH), acetolactate synthase, small subunit (EC 4.1.3.18), equivalent or highly similar to others e.g. O33113|ILVH_MYCLE|MLCB637.21 from Mycobacterium leprae (169 aa), FASTA scores: opt: 843,E(): 5.1e-47, (83.5% identity in 164 aa overlap); Q59499|ILVH_MYCAV|ILVN from Mycobacterium avium (167 aa),FASTA scores: opt: 798, E(): 3.7e-44, (81.05% identity in 169 aa overlap); Q9Z566|ILVN from Streptomyces coelicolor (174 aa), FASTA scores: opt: 678, E(): 1.7e-36, (64.8% identity in 159 aa overlap); etc. BELONGS TO THE ACETOLACTATE SYNTHASE SMALL SUBUNIT FAMILY.	X2BMT4,P65162	No									X2BMT4,P65162	P65162									
NC_002945.3	Mycobrowser_v4	CDS	3317745	3319601	.	-	0	Mb3028c	ilvB1		acetolactate synthase (large subunit) ilvb1 (acetohydroxy-acid synthase)	Mb3028c, ilvB1, len: 618 aa. Equivalent to Rv3003c,len: 618 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 618 aa overlap). Probable ilvB1,acetolactate synthase, large subunit (EC 4.1.3.18),equivalent or highly similar to others e.g. O33112|ILVB_MYCLE|MLCB637.20|ML1696 from Mycobacterium leprae (625 aa), FASTA scores: opt: 3653, E(): 5.4e-208,(87.1% identity in 627 aa overlap); Q59498|ILVB_MYCAV from Mycobacterium avium (621 aa), FASTA scores: opt: 3473,E(): 2.3e-197, (84.7% identity in 614 aa overlap); P42463|ILVB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (626 aa), FASTA scores: opt: 2754,E(): 5.9e-155, (65.8% identity in 589 aa overlap); etc. Contains PS00187 Thiamine pyrophosphate enzymes signature. COFACTOR: THIAMINE PYROPHOSPHATE, AND MAGNESIUM (BY SIMILARITY). Note that previously known as ilvB.	X2BN34,P0A623	No									X2BN34,P0A623	P0A623									
NC_002945.3	Mycobrowser_v4	CDS	3319963	3320301	.	+	0	Mb3029	cfp6		LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 6 (CFP-6)	Mb3029, cfp6, len: 112 aa. Equivalent to Rv3004,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). cfp6, low molecular weight protein antigen 6 (CFP-6) (cf note * below). Weak homology with Q9RKZ5|SC6D7.02 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (156 aa), FASTA scores: opt: 109, E(): 0.78, (39.4% identity in 122 aa overlap). CAUTION: THE INITIATOR METHIONINE MAY BE FURTHER UPSTREAM MAKING THE SEQUENCE A PRECURSOR. [* Note: Bhaskar S.,Mukherjee R.: Isolation, purification and immunological characterization of low molecular weight protein antigens from culture filtrate of Mycobacterium tuberculosis H37Rv. Unpublished. Submitted (NOV-1998) to the SWISS-PROT data bank].	X2BM45,P0A5P3	No	cell wall and cell processes								X2BM45,P0A5P3	P0A5P3				Rv3004		Rv3004			
NC_002945.3	Mycobrowser_v4	CDS	3323879	3325408	.	-	0	Mb3034c	gatB		PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT B) GATB (Glu-ADT SUBUNIT B)	Mb3034c, gatB, len: 509 aa. Equivalent to Rv3009c,len: 509 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 509 aa overlap). Probable gatB,Glu-tRNA-Gln amidotransferase, subunit B (EC 6.3.5.-),equivalent to O33107|GATB_MYCLE|MLCB637_15 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Mycobacterium leprae (509 aa), FASTA scores: opt: 2973, E(): 2.9e-173,(88.4% identity in 509 aa overlap). Also highly similar to other Glu- tRNA-Gln amidotransferases e.g. Q9Z578|GATB|SC8D9.13 from Streptomyces coelicolor (504 aa), FASTA scores: opt: 2264, E(): 3.6e-130, (66.0% identity in 495 aa overlap); P74215|GATB_SYNY3|SLL1435 from Synechocystis sp. strain PCC 6803 (519 aa), FASTA scores: opt: 1289, E(): 6.7e-71, (42.0% identity in 485 aa overlap); Q9X100|GATB_THEMA|TM1273 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Thermotoga maritima (482 aa), FASTA scores: opt: 1165, E(): 2.2e-63, (40.05% identity in 487 aa overlap); etc. For more information about function, see citation below. Similar to many members of the pet112 family. BELONGS TO THE GATB FAMILY.	X2BM48,P64200	No									X2BM48,P64200	P64200									
NC_002945.3	Mycobrowser_v4	CDS	3325438	3326469	.	-	0	Mb3035c	pfkA		PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	Mb3035c, pfkA, len: 343 aa. Equivalent to Rv3010c,len: 343 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 343 aa overlap). Probable pfkA,phosphofructokinase (EC 2.7.1.11), equivalent to O33106|K6PF_MYCLE|MLCB637.14 6-PHOSPHOFRUCTOKINASE from Mycobacterium leprae (343 aa), FASTA scores: opt: 2099,E(): 4.1e-122, (90.4% identity in 343 aa overlap). Also highly similar to others e.g. Q9FC99|K6P3_STRCO from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1329,E(): 1.1e-74, (58.9% identity in 338 aa overlap); Q9L1L8|K6P2_STRCO|PFKA2|PFK2|SC6A11.02 6-PHOSPHOFRUCTOKINASE 2 from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1303, E(): 4.5e-73, (56.7% identity in 342 aa overlap); Q9KH71|PFP PPI-DEPENDENT PHOSPHOFRUCTOKINASE from Dictyoglomus thermophilum (346 aa), FASTA scores: opt: 893, E(): 8.4e-48, (41.85% identity in 344 aa overlap); etc. Contains PS00433 Phosphofructokinase signature. BELONGS TO THE PHOSPHOFRUCTOKINASE FAMILY.	X2BMF7,P65691	No									X2BMF7,P65691	P65691									
NC_002945.3	Mycobrowser_v4	CDS	3326565	3328049	.	-	0	Mb3036c	gatA		PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	Mb3036c, gatA, len: 494 aa. Equivalent to Rv3011c,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 494 aa overlap). Probable gatA,Glu-tRNA-Gln amidotransferase, subunit A (EC 6.3.5.-),equivalent to O33105|GATA|ML1702|MLCB637.13 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Mycobacterium leprae (497 aa), FASTA scores: opt: 2839, E(): 3.5e-161,(88.8% identity in 492 aa overlap). Also highly similar to other Glu-tRNA-Gln amidotransferases e.g. Q9Z580|GATA_STRCO from Streptomyces coelicolor (497 aa),FASTA scores: opt: 2231, E(): 4.5e-125, (70.3% identity in 486 aa overlap); P73558|GATA_SYNY3|SLR0877 from Synechocystis sp. strain PCC 6803 (483 aa), FASTA scores: opt: 1593, E(): 3.3e-87, (55.85% identity in 487 aa overlap); O06491|GATA_BACSU GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Bacillus subtilis (485 aa), FASTA scores: opt: 1389, E(): 4.3e-75, (51.7% identity in 468 aa overlap); etc. For more information about function, see citation below. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE AMIDASE FAMILY.	X2BMB5,Q7TXG2	No									X2BMB5,Q7TXG2	Q7TXG2									
NC_002945.3	Mycobrowser_v4	CDS	3328046	3328345	.	-	0	Mb3037c	gatC		PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT C) GATC (Glu-ADT SUBUNIT C)	Mb3037c, gatC, len: 99 aa. Equivalent to Rv3012c,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Probable gatC,Glu-tRNA-Gln amidotransferase, subunit C (EC 6.3.5.-),equivalent to O33104|GATC_MYCLE|MLCB637.12 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE from Mycobacterium leprae (99 aa), FASTA scores: opt: 483, E(): 3.1e-25,(74.75% identity in 99 aa overlap). Also highly similar to other Glu-tRNA-Gln amidotransferases e.g. Q9Z581|GATC_STRCO|SC8D9.10 from Streptomyces coelicolor (98 aa), FASTA scores: opt: 298, E(): 4e-13, (53.7% identity in 95 aa overlap); O06492|GATC_BACSU from B. subtilis (96 aa), FASTA scores: opt: 222, E(): 3.7e-08,(43.15% identity in 95 aa overlap); Q9KF29|BH0665 from Bacillus halodurans (96 aa), FASTA scores: opt: 211, E(): 1.9e-07, (41.05% identity in 95 aa overlap); etc. For more information about function, see citation below. BELONGS TO THE GATC FAMILY.	X2BMU2,P64206	No									X2BMU2,P64206	P64206									
NC_002945.3	Mycobrowser_v4	CDS	3329160	3331235	.	-	0	Mb3039c	ligA		dna ligase [nad dependent] liga (polydeoxyribonucleotide synthase [nad+])	Mb3039c, ligA, len: 691 aa. Equivalent to Rv3014c,len: 691 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 691 aa overlap). Probable ligA (alternate gene name: lig), DNA ligase NAD-dependent (EC 6.5.1.2), equivalent to O33102|DNLJ_MYCLE|LIGA|LIG|ML1705|MLCB637.10 DNA LIGASE from Mycobacterium leprae (694 aa), FASTA scores: opt: 3844, E(): 0, (84.7% identity in 687 aa overlap). Also highly similar to many prokaryotic and eukaryotic ligases e.g. Q9Z585|LIGA|SC8D9.06 from Streptomyces coelicolor (735 aa), FASTA scores: opt: 2002, E(): 4e-113, (59.4% identity in 714 aa overlap); P49421|DNLJ_RHOMR|LIGA|LIG from Rhodothermus marinus (712 aa), FASTA scores: opt: 1835, E(): 4.6e-103, (45.55% identity in 685 aa overlap); P15042|DNLJ_ECOLI|LIGA|LIG|DNAL|PDEC|LOP|B2411 from Escherichia coli strain K12 (671 aa), FASTA scores: opt: 1696, E(): 1.1e-94, (43.8% identity in 680 aa overlap); etc. BELONGS TO THE NAD-DEPENDENT DNA LIGASE FAMILY.	X2BM51,P63974	No									X2BM51,P63974	P63974									
NC_002945.3	Mycobrowser_v4	CDS	3686614	3690630	.	-	0	Mb3375c	PPE54		ppe family protein ppe54	Mb3375c, PPE54, len: 1338 aa. Similar to 3' end of Rv3343c, len: 2523 aa, from Mycobacterium tuberculosis strain H37Rv, (98.6% identity in 1151 aa overlap). Member of the Mycobacterium tuberculosis PPE family, MPTR subgroup of Gly-, Asn-rich proteins. Most similar to O50379|Rv3350c|MTV004.07c|MTV004_5 from Mycobacterium tuberculosis strain H37Rv (3716 aa), FASTA scores: opt: 4672, E(): 4e-211, (44.2% identity in 3174 aa overlap); and also similar to MTV004_3, MTCY63_9, MTY13E10_17,MTY13E10_16, MTCY180_1, MTV050_1, MTCY3C7_23, MTV014_3,MTCY63_10; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3555 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TWP0	No								IPR000030,IPR002989	Q7TWP0	A0A1R3Y3X3									
NC_002945.3	Mycobrowser_v4	CDS	3333105	3333467	.	-	0	Mb3042c	esxQ		esat-6 like protein esxq (tb12.9) (esat-6 like protein 8)	Mb3042c, esxQ, len: 120 aa. Equivalent to Rv3017c,len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). esxQ, putative ESAT-6 like protein 8, possibly secreted protein, very similar to AAK47433|MT3104 PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis strain CDC1551 (96 aa),FASTA scores: opt: 315, E(): 1.2e-14, (65.7% identity in 70 aa overlap); Rv3019c|O53266|MTV012.33c PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 315, E(): 1.2e-14, (65.7% identity in 70 aa overlap) and Rv0288|O53693|CFP7|MT0301|MTV035.16 10 KDA ANTIGEN CFP7 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7) (CFP-7) from Mycobacterium tuberculosis (95 aa), FASTA scores: opt: 303, E(): 7.4e-14, (66.2% identity in 68 aa overlap). BELONGS TO THE ESAT6 FAMILY.	X2BMU7	No									X2BMU7	P64092									
NC_002945.3	Mycobrowser_v4	misc_RNA	3424360	3424966	.	-	0	ssr	ssr		10Sa RNA	ssr, len: 607 nt. Equivalent to ssr, len: 607 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 607 nt overlap). Match to EM_BA:MT10SARNA X60301 M.tuberculosis gene for 10Sa RNA.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3333554	3334867	.	-	0	Mb3043c	PPE46		ppe family protein ppe46	Mb3043c, PPE46, len: 437 aa. Equivalent to Rv3018c,len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 431 aa overlap). Member of PPE family but lacks Gly, Ala rich repeats at C-terminal domain,closest to MTCY261.19. Also very similar to following ORF MTV012.35c. Nearly identical in parts to Mycobacterium tuberculosis protein erroneously described as DIHYDROFOLATE REDUCTASE (X59271|MTFOLA_1) P31500|DYR_MYCTU (214 aa), FASTA scores: opt: 972, E(): 4.4e-42, (80.0% identity in 195 aa overlap); and Z97559|MTCY261_19 from M. tuberculosis cosmid (473 aa), FASTA scores: opt: 806, E(): 0; (38.8% identity in 479 aa overlap); and O53268|MTV012.35c from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 1714, E(): 3.3e-79, (78.3% identity in 355 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 56 bp deletion leads to a product slightly different at the Nh2-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa).	Q7TXF8	No								IPR000030	Q7TXF8	A0A1R3Y315									
NC_002945.3	Mycobrowser_v4	CDS	3335270	3335560	.	-	0	Mb3045c	esxR		secreted esat-6 like protein esxr (tb10.3) (esat-6 like protein 9)	Mb3045c, esxR, len: 96 aa. Equivalent to Rv3019c,len: 96 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 96 aa overlap). esxR, putative secreted ESAT-6 like protein 9 (see citations below), most similar to O53693|AAK44525|Rv0288|CFP7|MT0301|MTV035.16 10 KDA ANTIGEN CFP7 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7) (CFP-7) from Mycobacterium tuberculosis (95 aa), FASTA scores: opt: 566, E(): 5.1e-31, (84.3% identity in 95 aa overlap). Also similar to Q9CD33|ML2531 POSSIBLE CELL SURFACE PROTEIN from Mycobacterium leprae (96 aa), FASTA scores: opt: 472, E(): 8.3e-25, (66.6% identity in 96 aa overlap); O53264|Rv3017c|MTV012.31c PUTATIVE SECRETED ANTIGEN from Mycobacterium tuberculosis (120 aa), FASTA scores: opt: 321, E(): 9.6e-15, (67.15% identity in 70 aa overlap); Q57165|AAK48357|O84901|X79562|ESAT6|Rv3875|MT3989|MTV027.1 0esat6 gene from Mycobacterium tuberculosis strain Erdman (94 aa), FASTA scores: opt: 131, E(): 0.028, (26.1% identity in 88 aa overlap). BELONGS TO THE ESAT6 FAMILY. TBparse score is 0.906.	X2BMG4	No									X2BMG4	P64094									
NC_002945.3	Mycobrowser_v4	CDS	3335595	3335888	.	-	0	Mb3046c	esxS		esat-6 like protein esxs	Mb3046c, esxS, len: 97 aa. Equivalent to Rv3020c,len: 97 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 97 aa overlap). Member of Mycobacterium tuberculosis PE family (see first citation below), similar to others e.g. AAK44524|MT0300 PE FAMILY PROTEIN from M. tuberculosis strain CDC1551 (97 aa), FASTA scores: opt: 564, E(): 5.9e-30, (91.75% identity in 97 aa overlap). Has potential helix-turn-helix motif at positions 14-35. TBparse score is 0.912. SEEMS TO BELONG TO THE ESAT6 FAMILY (see second citation below).	Q7TXF7	No								IPR010310	Q7TXF7	A0A1R3Y2X0									
NC_002945.3	Mycobrowser_v4	CDS	3335935	3337242	.	-	0	Mb3047c	PPE47		ppe family protein ppe47	Mb3047c, PPE47, len: 435 aa. Equivalent to Rv3022c (PPE48) and Rv3021c (PPE47), len: 81 aa and 358 aa, from Mycobacterium tuberculosis strain H37Rv, (98.8% identity in 81 aa overlap and 98.6% identity in 354 aa overlap). Member of Mycobacterium tuberculosis PPE family. Should be continuation of upstream ORF MTV012.36c but is frameshifted due to missing base at 36448 in v012. Sequence has been checked but no error apparent. Very similar to neighbouring ORF O53265|MTV012.32c|Rv3018c from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 1714, E(): 6.6e-770, (78.3% identity in 355 aa overlap) and AAK47430|MT3101 (strongly in the N-terminal part) (310 aa), FASTA scores: opt: 897, E(): 4.5e-37, (66.95% identity in 227 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis, a single base insertion (*-g) leads to a single product.	Q7TXF6	No	PE/PPE							IPR000030	Q7TXF6	A0A1R3Y2W1				Rv3022c		Rv3022c			
NC_002945.3	Mycobrowser_v4	CDS	3339345	3340448	.	-	0	Mb3050c	trmU		PROBABLE tRNA (5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE TRMU	Mb3050c, trmU, len: 367 aa. Equivalent to Rv3024c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 367 aa overlap). Probable trmU, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61), equivalent to O33099|TRMU_MYCLE|ML1707|MLCB637.07 PROBABLE tRNA (5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE from Mycobacterium leprae (358 aa), FASTA scores: opt: 2033, E(): 5.5e-116, (85.45% identity in 357 aa overlap). Also highly similar to others e.g. O86583|TRMU_STRCO|SC2A11.22 from Streptomyces coelicolor (376 aa), FASTA scores: opt: 1336, E(): 1e-73, (56.9% identity in 369 aa overlap); BAB49856|MLR2824 from Rhizobium loti (378 aa), FASTA scores: opt: 826, E(): 8.3e-43, (42.35% identity in 359 aa overlap); Q9ZDM1|TRMU_RICPR|RP306 from Rickettsia prowazekii (358 aa), FASTA scores: opt: 800, E(): 3e-41, (40.1% identity in 359 aa overlap); etc. BELONGS TO THE TRMU FAMILY.	X2BMG7,P66977	No									X2BMG7,P66977	P66977									
NC_002945.3	Mycobrowser_v4	CDS	3340445	3341626	.	-	0	Mb3051c	iscS		cysteine desulfurase iscs (nifs protein homolog) (nitrogenase metalloclusters biosynthesis protein nifs)	Mb3051c, iscS, len: 393 aa. Equivalent to Rv3025c,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Probable iscS (alternate gene name: nifS), cysteine desulfurase (NifS-like protein) (EC 4.4.1.-), equivalent to MLCB637.06|O33098 NIFS-LIKE PROTEIN from Mycobacterium leprae (396 aa), FASTA scores: opt: 2186, E(): 2.7e-122,(84.9% identity in 391 aa overlap). Also highly similar to many e.g. O86581|SC2A11.20 PUTATIVE PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASE from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1568,E(): 1.1e-85, (61.7% identity in 389 aa overlap); P57795|ISCS|NIFS CYSTEINE DESULFURASE (NIFS PROTEIN HOMOLOG) from Methanosarcina thermophila (404 aa), FASTA scores: opt: 1059, E(): 1.6e-55, (46.2% identity in 381 aa overlap); O54055|ISCS_RUMFL|ISCS|NIFS CYSTEINE DESULFURASE from Ruminococcus flavefaciens (396 aa), FASTA scores: opt: 973, E(): 2e-50, (43.3% identity in 381 aa overlap); P57794|NIFS_ACEDI CYSTEINE DESULFURASE from Acetobacter diazotrophicus (400 aa), FASTA scores: opt: 958, E(): 1.6e-49, (41.1% identity in 392 aa overlap); etc. Also similar to Rv1464|MTV007.11 from Mycobacterium tuberculosis. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, NIFS/ISCS SUBFAMILY. COFACTOR: PYRIDOXAL PHOSPHATE (BY SIMILARITY).	Q7TXF4	No								IPR000192,IPR015421,IPR015422,IPR015424,IPR016454	Q7TXF4	A0A1R3Y4T3									
NC_002945.3	Mycobrowser_v4	CDS	3358493	3359722	.	-	0	Mb3068c	serB2		PROBABLE PHOSPHOSERINE PHOSPHATASE SERB2 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE)	Mb3068c, serB2, len: 409 aa. Equivalent to Rv3042c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 409 aa overlap). Probable serB2,Phosphoserine phosphatase (EC 3.1.3.3), equivalent to Q9CBQ6|ML1727 PUTATIVE PHOSPHOSERINE PHOSPHATASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 2173,E(): 1.3e-117, (86.3% identity in 408 aa overlap). Also similar to other e.g. Q9S281|SCI28.02 from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1209, E(): 3e-62,(51.75% identity in 400 aa overlap); Q9HUK|PA4960 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 704,E(): 3.1e-33, (40.95% identity in 393 aa overlap); O28142|SERB_ARCTU|AF2138 from Archaeoglobus fulgidus (344 aa), FASTA scores: opt: 671, E(): 2e-31, (37.25% identity in 325 aa overlap); and P06862|SERB_ECOLI (322 aa), FASTA scores: opt: 628, E(): 5.7e-29, (46.8% identity in 235 aa overlap). BELONGS TO THE SERB FAMILY.	Q7TXD8	No								IPR002912,IPR004469,IPR006383,IPR023190,IPR023214	Q7TXD8	A0A1R3Y2Y9									
NC_002945.3	Mycobrowser_v4	CDS	3343635	3344591	.	-	0	Mb3054c	fixB		PROBABLE ELECTRON TRANSFER FLAVOPROTEIN (ALPHA-SUBUNIT) FIXB (ALPHA-ETF) (ELECTRON TRANSFER FLAVOPROTEIN LARGE SUBUNIT) (ETFLS)	Mb3054c, fixB, len: 318 aa. Equivalent to Rv3028c,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 318 aa overlap). Probable fixB (alternate gene name: etfA), electron transfer flavoprotein (alpha subunit) for various dehydrogenases. Equivalent to O33096|ETFA_MYCLE|FIXB|ML1711|MLCB637.04 ELECTRON TRANSFER FLAVOPROTEIN from Mycobacterium leprae (318 aa), FASTA scores: opt: 1788, E(): 1.1e-87, (89.3% identity in 318 aa overlap). Also highly similar to many e.g. Q9K418|SCG22.27c from Streptomyces coelicolor (320 aa), FASTA scores: opt: 1161, E(): 1.6e-54, (59.45% identity in 323 aa overlap); AAK08137|etfa from Rhodobacter sphaeroides (308 aa), FASTA scores: opt: 792,E(): 5.1e-35, (45.95% identity in 309 aa overlap); P38974|ETFA_PARDE ELECTRON TRANSFER FLAVOPROTEIN from Paracoccus denitrificans (307 aa), FASTA scores: opt: 789,E(): 7.4e-35, (45.95% identity in 309 aa overlap); etc. BELONGS TO THE ETF ALPHA-SUBUNIT / FIXB FAMILY.	Q7TXF1	No								IPR001308,IPR014729,IPR014730,IPR014731,IPR018206	Q7TXF1	A0A1R3Y3A9									
NC_002945.3	Mycobrowser_v4	CDS	3344630	3345430	.	-	0	Mb3055c	fixA		PROBABLE ELECTRON TRANSFER FLAVOPROTEIN (BETA-SUBUNIT) FIXA (BETA-ETF) (ELECTRON TRANSFER FLAVOPROTEIN SMALL SUBUNIT) (ETFSS)	Mb3055c, fixA, len: 266 aa. Equivalent to Rv3029c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable fixA (alternate gene name: etfB), electron transfer flavoprotein (beta-subunit). Equivalent of O33095|ETFB_MYCLE|FixA|MLCB637.03 ELECTRON TRANSFER FLAVOPROTEIN from Mycobacterium leprae (266 aa), FASTA scores: opt: 1603, E(): 7.6e-87, (95.1% identity in 266 aa overlap). Also highly similar to others e.g. Q9K417|SCG22.28c from Streptomyces coelicolor (262 aa),FASTA scores: opt: 860, E(): 2.3e-43, (52.4% identity in 263 aa overlap); O85691|ETFB_MEGEL from Megasphaera elsdenii (270 aa), FASTA scores: opt: 548, E(): 4.2e-25,(35.15% identity in 273 aa overlap); etc. Also highly similar in particular to Q9KHD0|NONH FLAVOPROTEIN REDUCTASE from Streptomyces griseus subsp. griseus (this one is required for macrotetrolide biosynthesis in Streptomyces griseus) (261 aa), FASTA scores: opt: 867,E(): 8.8e-44, (54.0% identity in 263 aa overlap). BELONGS TO THE ETF BETA-SUBUNIT / FIXA FAMILY.	X2BMG9,P64098	No									X2BMG9,P64098	P64098									
NC_002945.3	Mycobrowser_v4	CDS	3355979	3356743	.	-	0	Mb3065c	echA17		PROBABLE ENOYL-COA HYDRATASE ECHA17 (CROTONASE) (UNSATURED ACYL-CoA HYDRATASE) (ENOYL HYDRASE)	Mb3065c, echA17, len: 254 aa. Equivalent to Rv3039c, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 254 aa overlap). Probable echA17, Enoyl-CoA Hydratase/Isomerase Superfamily member (crotonase) (EC 4.2.1.17). Similar to many e.g. Q9L1E6|SC3D11.16 PUTATIVE ENOYL-COA HYDRATASE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 625,E(): 1.5e-30, (45.55% identity in 224 aa overlap); O07137||ECH8_MYCLE|ML2402|MLCB1306.05c PROBABLE ENOYL-COA HYDRATASE ECHA8 from Mycobacterium leprae (257 aa), FASTA scores: opt: 448, E(): 6.4e-20, (35.3% identity in 235 aa overlap), P97087|CRT CROTONASE / ENOYL-COA HYDRATASE from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 420,E(): 3.1e-18, (31.2% identity in 234 aa overlap). Also similar to Mycobacterium tuberculosis AAK45356|O53418|Rv1070c|ECHA8|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE ECHA8 (257 aa), FASTA scores: opt: 450, E(): 4.9e-20, (36.4% identity in 226 aa overlap). BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY.	X2BMF2,Q7TXE1	No	lipid metabolism								X2BMF2,Q7TXE1	Q7TXE1				Rv3039c		Rv3039c			
NC_002945.3	Mycobrowser_v4	CDS	3373251	3374291	.	+	0	Mb3082	dinP		possible dna-damage-inducible protein p dinp (dna polymerase v) (pol iv 2) (dna nucleotidyltransferase (dna-directed))	Mb3082, dinP, len: 346 aa. Equivalent to Rv3056,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Possible dinP,DNA-damage-inducible protein, similar to other e.g. AAK45855|MT1589 from Mycobacterium tuberculosis strain CDC1551 (485 aa), FASTA scores: opt: 620, E(): 6.1e-32,(37.2% identity in 344 aa overlap); BAB49140|MLR1877 from Rhizobium loti (Mesorhizobium loti) (415 aa), FASTA scores: opt: 533, E(): 1.8e-26, (34.35% identity in 358 aa overlap); and BAB54888|MLL9709 from Rhizobium loti (Mesorhizobium loti) (361 aa), FASTA scores: opt: 532,E(): 1.8e-26, (35.35% identity in 348 aa overlap). Extensive similarity to proteins induced by DNA damage such as dinP, mucB, umuC.	X2BN83,P63988	No	information pathways								X2BN83,P63988	P63988				Rv3056		Rv3056			
NC_002945.3	Mycobrowser_v4	CDS	3359760	3361481	.	-	0	Mb3069c	ctaD		PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1)	Mb3069c, ctaD, len: 573 aa. Equivalent to Rv3043c,len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 573 aa overlap). Probable ctaD,integral membrane cytochrome C oxidase polypeptide I (EC 1.9.3.1), equivalent to Q9CBQ5|ML1728 from Mycobacterium leprae (574 aa), FASTA scores: opt: 3738, E(): 3.8e-216,(95.4% identity in 566 aa overlap). Also similar to other CYTOCHROME C OXIDASES POLYPEPTIDE I e.g. Q9AEL9|CTAD from Corynebacterium glutamicum (Brevibacterium flavum) (584 aa), FASTA scores: opt: 3065, E(): 6.8e-176, (72.65% identity in 567 aa overlap); Q9X813|SC6G10.28c from Streptomyces coelicolor (578 aa), FASTA scores: opt: 2888,E(): 2.6e-165, (71.7% identity in 544 aa overlap); Q9K451|CTAD from Streptomyces coelicolor (573 aa), FASTA scores: opt: 2757, E(): 1.8e-157, (70.2% identity in 537 aa overlap). Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature. BELONGS TO THE HEME-COPPER RESPIRATORY OXIDASE FAMILY.	X2BMH9,P63853	No									X2BMH9,P63853	P63853									
NC_002945.3	Mycobrowser_v4	CDS	3361696	3362775	.	+	0	Mb3070	fecB		PROBABLE FEIII-DICITRATE-BINDING PERIPLASMIC LIPOPROTEIN FECB	Mb3070, fecB, len: 359 aa. Equivalent to Rv3044,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable fecB, FeIII dicitrate-binding periplasmic lipoprotein (see citation below), equivalent to Q9CBQ4|FECB|ML1729 PUTATIVE FEIII-DICITRATE TRANSPORTER LIPOPROTEIN from Mycobacterium leprae (364 aa), FASTA scores: opt: 1816, E(): 1.1e-96,(75.65% identity in 357 aa overlap); and Q9LA57|FECB from M. avium (364 aa), FASTA scores: opt: 1769, E(): 5.1e-94. Similar to many periplasmic FeIII-dicitrate transporters e.g. P72593|FECB|SLR1319 from Synechocystis sp. strain PCC 6803 (315 aa), FASTA scores: opt: 459, E(): 3.6e-19,(31.35% identity in 303 aa overlap); and P72611|FECB|SLR1492 from Synechocystis sp. strain PCC 6803. N-terminus longer (approximatively 30 aa) to AAK47459 from Mycobacterium tuberculosis strain CDC1551 (327 aa). Has signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TXD7	No	cell wall and cell processes							IPR002491	Q7TXD7	A0A1R3Y4V9				Rv3044		Rv3044			
NC_002945.3	Mycobrowser_v4	CDS	3436248	3436499	.	+	0	Mb3139	moaD1		PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D MOAD1 (MOLYBDOPTERIN CONVERTING FACTOR SMALL SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 1)	Mb3139, moaD1, len: 83 aa. Equivalent to Rv3112,len: 83 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 83 aa overlap). Probable moaD1,molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to others e.g. Q9HJF0|TA1019 from Thermoplasma acidophilum (85 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); BAB59710|TVG0556526 from Thermoplasma volcanium (90 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); P30748|MOAD_ECOLI|CHLA4|CHLM|B0784 from Escherichia coli strain K12 (81 aa), FASTA scores: opt: 116, E(): 0.11,(36.9% identity in 84 aa overlap); etc. N-terminus also highly similar to to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 333, E(): 2e-16, (65.05% identity in 83 aa overlap); and some similarity with Rv0868c|MTV043.61c|MOAD2 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D 2 (92 aa). Note that previously known as moaD.	Q7TTR6	No	intermediary metabolism and respiration							IPR003749,IPR010034,IPR012675,IPR016155	Q7TTR6	A0A1R3Y520				Rv3112		Rv3112			
NC_002945.3	Mycobrowser_v4	CDS	3362845	3363885	.	+	0	Mb3071	adhC		PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC	Mb3071, adhC, len: 346 aa. Equivalent to Rv3045,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Probable adhC,NADP-dependent alcohol dehydrogenase (EC 1.1.1.2),equivalent to Q9CBQ3|ADHA|ML1730 ALCOHOL DEHYDROGENASES from Mycobacterium leprae (362 aa), FASTA scores: opt: 1982, E(): 1.3e-111, (85.85% identity in 346 aa overlap); Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347 aa overlap); Q9EWF1|SCK13.33c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (346 aa), FASTA scores: opt: 1508,E(): 3.3e-83, (64.45% identity in 346 aa overlap); O06007|ADHA from Bacillus subtilis (349 aa), FASTA scores: opt: 1412, E(): 1.9e-77, (61.8% identity in 335 aa overlap); etc. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY. HIGH SIMILARITY WITH OTHER BACTERIAL ADH'S.	X2BMX0,P0A4X1	No	intermediary metabolism and respiration								X2BMX0,P0A4X1	P0A4X1				Rv3045		Rv3045			
NC_002945.3	Mycobrowser_v4	CDS	3364964	3365938	.	-	0	Mb3074c	nrdF2		RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF2 (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN)	Mb3074c, nrdF2, len: 324 aa. Equivalent to Rv3048c,len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 324 aa overlap). nrdF2,ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1) (see citation below), equivalent to Q9CBQ2|RIR2_MYCL|NRDF|ML1731 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN from Mycobacterium leprae (325 aa),FASTA scores: opt: 2009, E(): 1.3e-123, (93.5% identity in 324 aa overlap). Also similar to other ribonucleoside-diphosphate reductases e.g. Q9XD62|NRDF from Corynebacterium glutamicum (Brevibacterium flavum) (334 aa), FASTA scores: opt: 1648, E(): 4.2e-100, (78.35% identity in 314 aa overlap); O69274|NRDF from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (329 aa), FASTA scores: opt: 1626, E(): 1.1e-98, (75.3% identity in 320 aa overlap); P37146|NRDF|B2676 from Escherichia coli (319 aa), FASTA scores: opt: 1569, E(): 5.7e-95, (71.3% identity in 317 aa overlap). Contains PS00368 Ribonucleotide reductase small subunit signature. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. COFACTOR: BINDS 2 IRON IONS (BY SIMILARITY). Note that previously known as nrdG.	Q7TXD4	No								IPR000358,IPR009078,IPR012348,IPR026023,IPR026494	Q7TXD4	A0A1R3Y2Y4									
NC_002945.3	Mycobrowser_v4	CDS	3368645	3370726	.	-	0	Mb3077c	nrdE		ribonucleoside-diphosphate reductase (alpha chain) nrde (ribonucleotide reductase small subunit) (r1f protein)	Mb3077c, nrdE, len: 693 aa. Equivalent to Rv3051c,len: 693 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 693 aa overlap). nrdE,ribonucleotide-diphosphate reductase, alpha chain (EC 1.17.4.1) (see citations below), equivalent to Q9CBQ0|NRDE|ML1734 from Mycobacterium leprae (693 aa),FASTA scores: opt: 4259,E(): 0, (93.2% identity in 693 aa overlap). Similar to other Ribonucleoside-diphosphate reductases e.g. Q9XD63|NRDE from Corynebacterium glutamicum (Brevibacterium flavum) (707 aa), FASTA scores: opt: 3683,E(): 0, (79.35% identity in 693 aa overlap); O69273|NRDE from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (720 aa), FASTA scores: opt: 3555, E(): 1.7e-214, (76.1% identity in 694 aa overlap); P39452|NRDE|B2675 from Escherichia coli (713 aa), FASTA scores: opt: 3430, E(): 1.1e-206, (73.6% identity in 693 aa overlap); etc. Equivalent to AAK47468|MT3137 from Mycobacterium tuberculosis strain CDC1551 (725 aa) but shorter in N-terminus. Contains PS00089 Ribonucleotide reductase large subunit signature. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE LARGE CHAIN FAMILY.	X2BN79,P0A5W9	No									X2BN79,P0A5W9	P0A5W9									
NC_002945.3	Mycobrowser_v4	CDS	3370792	3371244	.	-	0	Mb3078c	nrdI		PROBABLE NRDI PROTEIN	Mb3078c, nrdI, len: 150 aa. Equivalent to Rv3052c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 150 aa overlap). Probable nrdI,equivalent to Q9CBP9|NRDI|ML1735 from Mycobacterium leprae (138 aa), FASTA scores: opt: 765, E(): 3.8e-44, (79.7% identity in 138 aa overlap), and similar to many NRDI PROTEINS e.g. Q47415|NRDI_ECOLI|B2674 from Escherichia coli (136 aa), FASTA scores: opt: 574, E(): 1.9e-31,(62.2% identity in 135 aa overlap). BELONGS TO THE NRDI FAMILY.	X2BM85	No									X2BM85	P65549									
NC_002945.3	Mycobrowser_v4	CDS	3371279	3371518	.	-	0	Mb3079c	nrdH		PROBABLE GLUTAREDOXIN ELECTRON TRANSPORT COMPONENT OF NRDEF (GLUTAREDOXIN-LIKE PROTEIN) NRDH	Mb3079c, nrdH, len: 79 aa. Equivalent to Rv3053c,len: 79 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 79 aa overlap). Probable nrdH,glutaredoxin-like protein, equivalent to Q9CBP8|NRDH|ML1736 from Mycobacterium leprae (80 aa),FASTA scores: opt: 478, E(): 2.7e-27, (91.15% identity in 79 aa overlap), and similar to many glutaredoxin-like proteins e.g. Q9XD65|NRDH from Corynebacterium glutamicum (Brevibacterium flavum) (77 aa), FASTA scores: opt: 382,E(): 1.5e-20, (72.35% identity in 76 aa overlap); and Q56108|NRDH_SALTY from Salmonella typhimurium (81 aa),FASTA scores: opt: 243, E(): 9.9e-11, (45.85% identity in 72 aa overlap). BELONGS TO THE GLUTAREDOXIN FAMILY.	Q7TXD1	No								IPR002109,IPR011909,IPR012336	Q7TXD1	A0A1R3Y306									
NC_002945.3	Mycobrowser_v4	CDS	3376038	3377516	.	+	0	Mb3085	cyp136		PROBABLE CYTOCHROME P450 136 CYP136	Mb3085, cyp136, len: 492 aa. Equivalent to Rv3059,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Probable cyp136,cytochrome P450 136 (EC 1.14.-.-), similar to other cytochrome P450-dependent oxidases e.g. Q59990|CYP120|CYP|SLR0574 PUTATIVE CYTOCHROME P450 120 from Synechocystis sp. strain PCC 6803 (444 aa), FASTA scores: opt: 579, E(): 1.5e-29, (27.3% identity in 443 aa overlap); Q64654|CYP51|CP51_RAT CYTOCHROME P450 51 (EC 1.14.14.-) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Rattus norvegicus (Rat) (503 aa), FASTA scores: opt: 549, E(): 1.4e-27, (26.2% identity in 458 aa overlap); Q9JIY3|CYP51 LANOSTEROL 14-ALPHA-DEMETHYLASE from Mus musculus (Mouse) (486 aa), FASTA scores: opt: 546, E(): 2.1e-27, (25.75% identity in 458 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY.	Q7TXC6	No								IPR001128,IPR002403,IPR017972	Q7TXC6	A0A1R3Y314									
NC_002945.3	Mycobrowser_v4	CDS	3382131	3383654	.	+	0	Mb3089	ligB		probable atp-dependent dna ligase ligb (polydeoxyribonucleotide synthase [atp]) (polynucleotide ligase [atp]) (sealase) (dna repair protein) (dna joinase)	Mb3089, ligB, len: 507 aa. Equivalent to Rv3062,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 507 aa overlap). Probable ligB, DNA ligase ATP-dependent (EC 6.5.1.1), highly similar to numerous archaebacterial and eukaryotic polynucleotide DNA ligases, e.g. Q9FCB1|DNLI_STRCO|LIG|2SCG58.02 from Streptomyces coelicolor (512 aa), FASTA scores: opt: 1677,E(): 2.5e-90, (55.65% identity in 512 aa overlap); Q9HR35|DNLI_HALN1|LIG|VNG0881G from Halobacterium sp. strain NRC-1 (561 aa), FASTA scores: opt: 985, E(): 5.6e-50, (42.25% identity in 440 aa overlap); Q9V185|DNLI_PYRAB|LIG|PAB2002 from Pyrococcus abyssi (559 aa), FASTA scores: opt: 978, E(): 1.4e-49, (39.05% identity in 443 aa overlap); etc. Also similar to Rv3731|MTV025.079|LIGC POSSIBLE DNA LIGASE from M. tuberculosis (358 aa). Similarity at N-terminus is poor so first start codon was taken. Contains (PS00697) ATP-dependent DNA ligase AMP-binding site signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-DEPENDENT DNA LIGASE FAMILY.	X2BMJ3,Q7TTR7	No	information pathways								X2BMJ3,Q7TTR7	Q7TTR7				Rv3062		Rv3062			
NC_002945.3	Mycobrowser_v4	CDS	3379808	3381610	.	-	0	Mb3087c	fadE22b		PROBABLE ACYL-COA DEHYDROGENASE FADE22b [SECOND PART]	Mb3087c, fadE22b, len: 600 aa. Equivalent to 3' end of Rv3061c, len: 721 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 600 aa overlap). Probable fadE22, Acyl-CoA Dehydrogenase (EC 1.3.99.-),similar to many e.g. AAK44503|MT0284 from Mycobacterium tuberculosis strain CDC1551 (731 aa), FASTA scores: opt: 1804, E(): 1.1e-101, (43.45% identity in 743 aa overlap); AAK48037|MT3678 from Mycobacterium tuberculosis strain CDC1551 (711 aa), FASTA scores: opt: 1630, E(): 3.9e-91,(42.55% identity in 733 aa overlap); and extensive similarity in C-terminal part to many acyl-CoA dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 767, E(): 4.8e-39,(36.7% identity in 376 aa overlap). Also similar to many hypothetical proteins. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits fadE22 into 2 parts,fadE22a and fadE22b.	Q7TXC4	No								IPR006091,IPR009075,IPR009100,IPR013786	Q7TXC4	A0A1R3Y2Z8									
NC_002945.3	Mycobrowser_v4	CDS	3381630	3381974	.	-	0	Mb3088c	fadE22a		PROBABLE ACYL-COA DEHYDROGENASE FADE22a [FIRST PART]	Mb3088c, fadE22a, len: 114 aa. Equivalent to 5' end of Rv3061c, len: 721 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 111 aa overlap). Probable fadE22, Acyl-CoA Dehydrogenase (EC 1.3.99.-),similar to many e.g. AAK44503|MT0284 from Mycobacterium tuberculosis strain CDC1551 (731 aa), FASTA scores: opt: 1804, E(): 1.1e-101, (43.45% identity in 743 aa overlap); AAK48037|MT3678 from Mycobacterium tuberculosis strain CDC1551 (711 aa), FASTA scores: opt: 1630, E(): 3.9e-91,(42.55% identity in 733 aa overlap); and extensive similarity in C-terminal part to many acyl-CoA dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 767, E(): 4.8e-39,(36.7% identity in 376 aa overlap). Also similar to many hypothetical proteins. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits fadE22 into 2 parts,fadE22a and fadE22b.	Q7TXC3	No								IPR009100,IPR013786	Q7TXC3	A0A1R3Y307									
NC_002945.3	Mycobrowser_v4	CDS	3425848	3426330	.	-	0	Mb3127c	smpB		PROBABLE SSRA-BINDING PROTEIN SMPB	Mb3127c, smpB, len: 160 aa. Equivalent to Rv3100c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Probable smpB, small protein b related to several bacterial small protein b homologs e.g. O32881|SSRP_MYCLE|ML0671|MLCB1779.19c from Mycobacterium leprae (160 aa), FASTA scores: opt: 914,E(): 1.1e-52, (84.9% identity in 159 aa overlap); Q9L1S9|SMPB from Streptomyces coelicolor (159 aa), FASTA scores: opt: 568, E(): 3.3e-30, (55.15% identity in 145 aa overlap); O32230|SSRP_BACSU from Bacillus subtilis (156 aa), FASTA scores: opt: 511, E(): 1.7e-26, (47.05% identity in 153 aa overlap); etc. BELONGS TO THE SSRP FAMILY.	X2BMB6,P0A613	No									X2BMB6,P0A613	P0A613									
NC_002945.3	Mycobrowser_v4	CDS	3383790	3386066	.	+	0	Mb3090	cstA		PROBABLE CARBON STARVATION PROTEIN A HOMOLOG CSTA	Mb3090, cstA, len: 758 aa. Equivalent to Rv3063,len: 758 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 758 aa overlap). Probable cstA,integral membrane starvation-induced stress response protein, similar to other e.g. P15078|CSTA_ECOLI|B0598 from Escherichia coli strain K12 (701 aa), FASTA scores: opt: 2357, E(): 9.5e-137, (51.25% identity in 712 aa overlap); AAG54933|CSTA from Escherichia coli strain O157:H7 EDL933 (701 aa), FASTA scores: opt: 2356, E(): 1.1e-136, (51.1% identity in 712 aa overlap); etc. Predicted to be membrane associated. Similarity suggests start at GTG at 16801 in Y22D7 but no RBS obvious so TBparse-predicted start at 16881 taken. BELONGS TO THE CSTA FAMILY.	Q7TXC2	No	virulence, detoxification, adaptation							IPR003706,IPR025299	Q7TXC2	A0A1R3Y4W9				Rv3063		Rv3063			
NC_002945.3	Mycobrowser_v4	CDS	3386934	3387257	.	+	0	Mb3092	mmr		MULTIDRUGS-TRANSPORT INTEGRAL MEMBRANE PROTEIN MMR	Mb3092, mmr, len: 107 aa. Equivalent to Rv3065,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 107 aa overlap). mmr, integral membrane multidrugs resistance transporter (see citation below), equivalent to Q9CBP1|ML1756 PROBABLE MULTIDRUG RESISTANCE PROTEIN from Mycobacterium leprae (107 aa),FASTA scores: opt: 534, E(): 3.3e-28, (77.55% identity in 107 aa overlap). Also highly similar to bacterial proteins involved in resistance to ethidium bromide or methyl viologen e.g. O87866|QACG_STASP QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACG (QUARTERNARY AMMONIUM DETERMINANT G) from Staphylococcus sp. strain ST94 (107 aa), FASTA scores: opt: 307, E(): 1.8e-13, (39.8% identity in 103 aa overlap); P96460|QAC QUATERNARY AMMONIUM COMPOUNDS RESISTANCE PROTEIN QAC from Staphylococcus aureus (107 aa), FASTA scores: opt: 304, E(): 2.8e-13,(40.4% identity in 104 aa overlap); Q57225|QACE_ECOLI QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACE (QUARTERNARY AMMONIUM DETERMINANT E) from Escherichia coli (110 aa), FASTA scores: opt: 300, E(): 5.2e-13, (48.15% identity in 108 aa overlap); AAG55967|Z1870 METHYLVIOLOGEN RESISTANCE PROTEIN ENCODED WITHIN PROPHAGE CP-933X from Escherichia coli strain O157:H7 EDL933 (110 aa); P23895|EMRE|MVRC|EB|B0543 EMRE PROTEIN from Escherichia coli (110 aa), FASTA scores: opt: 290, E(): 2.3e-12,(43.55% identity in 101 aa overlap); etc. Also similar to the SugE protein of enteric bacteria. BELONGS TO THE SMALL MULTIDRUG RESISTANCE (SMR) PROTEIN FAMILY. Note that previously known as emrE.	X2BN92,P69927	No	cell wall and cell processes								X2BN92,P69927	P69927				Rv3065		Rv3065			
NC_002945.3	Mycobrowser_v4	CDS	3388526	3390169	.	-	0	Mb3095c	pgmA		PROBABLE PHOSPHOGLUCOMUTASE PGMA (GLUCOSE PHOSPHOMUTASE) (PGM)	Mb3095c, pgmA, len: 547 aa. Equivalent to Rv3068c,len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 547 aa overlap). Probable pgmA,phosphoglucomutase (EC 5.4.2.2), highly similar to other phosphoglucomutases e.g. Q9L117|PGM from Streptomyces coelicolor (546 aa), FASTA scores: opt: 2569, E(): 2.8e-149, (71.4% identity in 545 aa overlap); Q9ABY5|CC0085 from Caulobacter crescentus (545 aa), FASTA scores: opt: 2465, E(): 6.2e-143, (70.4% identity in 541 aa overlap); P38569|PGMU_ACEXY|CELB from Acetobacter xylinum (555 aa), FASTA scores: opt: 2206, E(): 4e-127,(62.25% identity in 543 aa overlap); P74643|PGM|SLL0726 from Synechocystis sp. strain PCC 6803 (567 aa), FASTA scores: opt: 2168, E(): 8.5e-125, (60.0% identity in 550 aa overlap); P36938|PGMU_ECOLI|PGM|B0688 from Escherichia coli (546 aa), FASTA scores: opt: 2111, E(): 2.5e-121,(58.2% identity in 550 aa overlap). Also similar to other phosphomannomutases. Has phosphoglucomutase and phosphomannomutase signature (PS00710) and ATP/GTP-binding site motif A (P-loop) (PS00017). BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY.	Q7TXB8	No								IPR005843,IPR005844,IPR005845,IPR005846,IPR005852,IPR016055,IPR016066	Q7TXB8	A0A1R3Y324									
NC_002945.3	Mycobrowser_v4	CDS	3397900	3398301	.	+	0	Mb3105	hab		PROBABLE HYDROXYLAMINOBENZENE MUTASE HAB	Mb3105, hab, len: 133 aa. Equivalent to Rv3078,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable hab,hydroxylaminobenzene mutase (5.-.-.-) (see experiments in first citation), highly similar to two hydroxylaminobenzene mutases from Pseudomonas pseudoalcaligenes O52214|HABA (135 aa), FASTA scores: opt: 495, E(): 6.8e-25, (51.1% identity in 133 aa overlap); and O52216|HABB (164 aa), FASTA scores: opt: 479, E(): 8.2e-24, (51.9% identity in 133 aa overlap) (see first citation); and to Q9AH35|NBZB HYDROXYLAMINOBENZENE MUTASE from Pseudomonas putida (164 aa), FASTA scores: opt: 476,E(): 1.3e-23, (51.8% identity in 133 aa overlap) (see second citation). Gene name according to Pseudomonas pseudoalcaligenes nomenclature. Also similarity with putative different membrane proteins involved in transport (protein predicted to be a transmembrane protein).	Q7TXB1	No	intermediary metabolism and respiration								Q7TXB1					Rv3078		Rv3078			
NC_002945.3	Mycobrowser_v4	CDS	3399203	3402535	.	-	0	Mb3107c	pknK		serine/threonine-protein kinase transcriptional regulatory protein pknk (protein kinase k) (stpk k)	Mb3107c, pknK, len: 1110 aa. Equivalent to Rv3080c,len: 1110 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1110 aa overlap). Probable pknK,serine/threonine protein kinase involved in transcriptional regulatory function (EC 2.7.1.-) (see citation below). Similar but shorter in N-terminus (approximatively 300 residues) to others e.g. Q48411|ACOK TRANSCRIPTIONAL REGULATORY PROTEIN OF aco ABCD operon from Klebsiella pneumoniae (921 aa), FASTA scores: opt: 886,E(): 7.6e-37, (27.75% identity in 829 aa overlap); Q9HX92|PA3921 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (906 aa), FASTA scores: opt: 760, E(): 1.5e-30, (29.55% identity in 822 aa overlap); Q9I2X9|PA1760 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (907 aa), FASTA scores: opt: 696, E(): 2.3e-27, (25.85% identity in 685 aa overlap); P06993|MALT (alias BAB37683|ECS4260 and AAG58520|MALT) POSITIVE REGULATOR OF MAL REGULON from Escherichia coli strain O157:H7 (901 aa), FASTA scores: opt: 660, E(): 1.4e-25, (29.25% identity in 530 aa overlap); Q9KNF3|VCA0011 MALT REGULATORY PROTEIN from Vibrio cholerae (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (921 aa), FASTA scores: opt: 626, E(): 7.2e-24, (25.8% identity in 659 aa overlap); etc. N-terminal region similar to N-terminus of serine/threonine kinases e.g. Q9KK90|PKMA SERINE/THREONINE KINASE (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (589 aa), FASTA scores: opt: 545, E(): 5.7e-20, (34.45% identity in 334 aa overlap); Q9RPT5|AMK SERINE/THREONINE PROTEIN KINASE HOMOLOG (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (606 aa), FASTA scores: opt: 537, E(): 1.5e-19, (35.55% identity in 346 aa overlap); Q9L0I0|PKAD PROTEIN SERINE/THREONINE KINASE from Streptomyces coelicolor (599 aa), FASTA scores: opt: 520,E(): 1e-18, (36.1% identity in 324 aa overlap); etc. N-terminal part also similar to O53510|PKNL_MYCTU|Rv2176|MT2232|MTV021.09 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis strain H37Rv (399 aa), FASTA scores: opt: 511, E(): 2.1e-18, (35.15% identity in 313 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains Hank's kinase subdomain. FIRST PART OF THE PROTEIN SEEMS BELONG TO THE SER/THR FAMILY OF PROTEIN KINASES, AND SECOND PARTS SEEMS BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS.	X2BNB1,Q7TXA9	No									X2BNB1,Q7TXA9										
NC_002945.3	Mycobrowser_v4	CDS	3403951	3404973	.	-	0	Mb3109c	virS		VIRULENCE-REGULATING TRANSCRIPTIONAL REGULATOR VIRS (ARAC/XYLS FAMILY)	Mb3109c, virS, len: 340 aa. Equivalent to Rv3082c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). virS, transcriptional regulatory protein araC/xylS family, probably involved in virulence (see citation below). Similar to many transcriptional regulators araC/xylS family e.g. Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR (ARAC/XYLS FAMILY) from Pseudomonas aeruginosa (337 aa),FASTA scores: opt: 379, E(): 3e-17, (30.4% identity in 306 aa overlap); Q9Z3Y6|PHBR POLYHYDROXYBUTYRATE TRANSCRIPTIONAL ACTIVATOR from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 336, E(): 2e-14, (26.35% identity in 334 aa overlap); P72171|ORUR|PA0831 ORNITHINE UTILIZATION TRANSCRIPTIONAL REGULATOR oruR from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 274,E(): 1.9e-10, (23.7% identity in 321 aa overlap); Q9ZFW7 VIRULENCE REGULATING HOMOLOG from Pseudomonas alcaligenes (346 aa), FASTA scores: opt: 262, E(): 1.2e-09, (24.5% identity in 339 aa overlap); etc. Also similar to O69703|Rv3736|MTV025.084 PUTATIVE REGULATORY PROTEIN (ARAC/XYLS FAMILY) from Mycobacterium tuberculosis strain H37Rv (353 aa), FASTA scores: opt: 656, E(): 3.5e-35,(36.95% identity in 333 aa overlap). Has potential helix-turn-helix motif at positions 252-273. BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TXA7	No								IPR009057,IPR018060	Q7TXA7										
NC_002945.3	Mycobrowser_v4	CDS	3406544	3407470	.	+	0	Mb3111	lipR		PROBABLE ACETYL-HYDROLASE/ESTERASE LIPR	Mb3111, lipR, len: 308 aa. Equivalent to Rv3084,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable lipR,N-Acetyl-hydrolase/esterase (EC 3.1.1.-), similar to other e.g. Q01109|BAH_STRH from Streptomyces hygroscopicus (299 aa), FASTA scores: opt: 558, E(): 4.1e-26, (40.25% identity in 246 aa overlap); Q9X8J4|SCE9.22 from Streptomyces coelicolor (266 aa), FASTA scores: opt: 544,E(): 2.5e-25, (36.95% identity in 257 aa overlap); Q56171|DEA from Streptomyces viridochromogenes (299 aa),FASTA scores: opt: 532, E(): 1.4e-24, (38.6% identity in 254 aa overlap); etc. Also similar to O06350|LIPF|Rv3487c|MTCY13E12.41c (277 aa), FASTA score: opt: 291, E(): 8.5e-10, (28.5% identity in 239 aa overlap). MAY BE BELONG TO THE 'GDXG' FAMILY OF LIPOLYTIC ENZYMES.	Q7TXA5	No	intermediary metabolism and respiration							IPR013094	Q7TXA5					Rv3084		Rv3084			
NC_002945.3	Mycobrowser_v4	CDS	3408328	3409434	.	+	0	Mb3113	adhD		PROBABLE ZINC-TYPE ALCOHOL DEHYDROGENASE ADHD (ALDEHYDE REDUCTASE)	Mb3113, adhD, len: 368 aa. Equivalent to Rv3086,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 368 aa overlap). Probable adhD,zinc-type alcohol dehydrogenase (EC 1.1.1.-), highly similar to many e.g. O69045 HYPOTHETICAL ALCOHOL DEHYDROGENASE from Rhodococcus rhodochrous (370 aa), FASTA scores: opt: 1255, E(): 8.7e-68, (50.4% identity in 367 aa overlap); P25406|ADHB_UROHA ALCOHOL DEHYDROGENASE I-B from Uromastyx hardwickii (Indian spiny-tailed lizard) (375 aa), FASTA scores: opt: 787, E(): 8.2e-40, (35.9% identity in 373 aa overlap); P72324||ADHI_RHOSH ALCOHOL DEHYDROGENASE CLASS III from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (376 aa), FASTA scores: opt: 787, E(): 8.3e-40, (35.1% identity in 379 aa overlap). Also highly similar to P71818|Rv0761c|MTCY369.06c HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN from Mycobacterium tuberculosis strain H37Rv (375 aa), FASTA scores: opt: 1186, E(): 1.2e-63, (47.3% identity in 368 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE. POSSIBLY REQUIRES ZINC FOR ITS ACTIVITY.	Q7TXA3	No	intermediary metabolism and respiration							IPR002085,IPR002328,IPR011032,IPR013149,IPR013154,IPR016040,IPR023921	Q7TXA3					Rv3086		Rv3086			
NC_002945.3	Mycobrowser_v4	CDS	3410887	3412311	.	+	0	Mb3115	tgs4		putative triacylglycerol synthase (diacylglycerol acyltransferase) tgs4	Mb3115, -, len: 474 aa. Equivalent to Rv3088, len: 474 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 474 aa overlap). Hypothetical protein,similar to several Mycobacterium tuberculosis proteins e.g. MTCY31.23 (505 aa), MTCY13E12.34c (497 aa) and MTCY493.29c (459 aa). Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa).	X2BML1,P67209	No	lipid metabolism								X2BML1,P67209					Rv3088		Rv3088			
NC_002945.3	Mycobrowser_v4	CDS	3412308	3413819	.	+	0	Mb3116	fadD13		PROBABLE CHAIN-FATTY-ACID-CoA LIGASE FADD13 (FATTY-ACYL-CoA SYNTHETASE)	Mb3116, fadD13, len: 503 aa. Equivalent to Rv3089,len: 503 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 503 aa overlap). Probable fadD13,Acyl-CoA Synthetase (EC 6.2.1.-), similar to many e.g. MTCI28.06, MTCY08D5.09, MTCY06G11.08 from Mycobacterium tuberculosis strain H37Rv; and to Q9F7P5 PREDICTED ACID--CoA LIGASE FADD13 from uncultured proteobacterium EBAC31A08 (504 aa), FASTA scores: opt: 1126, E(): 2.4e-62,(38.85% identity in 502 aa overlap); Q9EY88|FCS FERULOYL-CoA SYNTHETASE from Amycolatopsis sp. strain HR167 (491 aa), FASTA scores: opt: 1073, E(): 4.5e-59,(38.5% identity in 504 aa overlap); BAB49118|MLR1843 PROBABLE ACID-CoA LIGASE from Rhizobium loti (Mesorhizobium loti) (495 aa), FASTA scores: opt: 937,E(): 1.2e-50, (36.2% identity in 503 aa overlap); Q9KZC1|SC6F7.21 PROBABLE LONG-CHAIN-FATTY-ACID-CoA LIGASE from Streptomyces coelicolor (511 aa), FASTA scores: opt: 899, E(): 2.8e-48, (36.1% identity in 510 aa overlap); Q9A5P7|CC2400 PUTATIVE ACID-CoA LIGASE from Caulobacter crescentus (496 aa), FASTA scores: opt: 874, E(): 9.8e-47,(35.1% identity in 507 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature and PS00061 Short-chain alcohol dehydrogenase family signature. TBparse score is 0.877.	Q7TXA1	No								IPR000873,IPR020845,IPR025110	Q7TXA1										
NC_002945.3	Mycobrowser_v4	CDS	3427227	3427916	.	-	0	Mb3129c	ftsE		PUTATIVE CELL DIVISION ATP-BINDING PROTEIN FTSE (SEPTATION COMPONENT-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER)	Mb3129c, ftsE, len: 229 aa. Equivalent to Rv3102c,len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Putative ftsE, cell division protein, septation component transport ATP-binding protein ABC transporter (see citations below),equivalent to O32883|FTSE|ML0669 CELL DIVISION ATP-BINDING PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1384, E(): 2.4e-74, (91.7% identity in 229 aa overlap); and similar to Q9L1S6|FTSE from Streptomyces coelicolor (229 aa), FASTA scores: opt: 914, E(): 8.7e-47,(62.85% identity in 226 aa overlap); Q9A0S4|FTSE|SPY0644 from Streptococcus pyogenes (230 aa), FASTA scores: opt: 866, E(): 5.7e-44, (57.9% identity in 228 aa overlap); Q9CGX0|FTSE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (230 aa), FASTA scores: opt: 792,E(): 1.3e-39, (52.2% identity in 228 aa overlap); etc. Other relatives from Mycobacterium tuberculosis include: MTCY253.24; MTCY16B7.10; MTCY9C4.04c; MTCY50.01; MTCY05A6.09c; MTCY04C12.31. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and ABC transporters family signature (PS00211). BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TX90	No								IPR003439,IPR003593,IPR005286,IPR017871,IPR027417	Q7TX90										
NC_002945.3	Mycobrowser_v4	CDS	3422325	3423638	.	-	0	Mb3124c	lipy		pe-pgrs family protein, triacylglycerol lipase lipy (esterase/lipase) (triglyceride lipase) (tributyrase)	Mb3124c, PE_PGRS63, len: 437 aa. Equivalent to Rv3097c, len: 437 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 437 aa overlap). Probable Triacylglycerol lipase (EC 3.1.1.3), and member of the M. tuberculosis PE-family PGRS subfamily of gly-rich proteins; N-terminal part similar to N-terminus of M. tuberculosis PE-PGRS family members e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd protein (603 aa). Other relatives include MTCY1A11.25c; MTCY21B4.13c; MTCY270.06; MTCY359.33; MTC1A11.04.	Q7TX94	No								IPR000084,IPR013094	Q7TX94										
NC_002945.3	Mycobrowser_v4	CDS	3426333	3427226	.	-	0	Mb3128c	ftsX		PUTATIVE CELL DIVISION PROTEIN FTSX (SEPTATION COMPONENT-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER)	Mb3128c, ftsX, len: 297 aa. Equivalent to Rv3101c,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 297 aa overlap). Putative ftsX, cell division protein, septation component transport integral membrane protein ABC transporter (see citations below),equivalent to O32882|FTSX_MYCLE|ML0670|MLCB1779.20c CELL DIVISION PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1597, E(): 9.2e-93, (80.8% identity in 297 aa overlap); and similar to others e.g. Q9L1S7|SCE59.27c from Streptomyces coelicolor (305 aa), FASTA scores: opt: 585,E(): 1.9e-29, (34.55% identity in 304 aa overlap); O34876|FTSX_BACSU from Bacillus subtilis (296 aa), FASTA scores: opt: 318, E(): 9.1e-13, (24.65% identity in 300 aa overlap); Q9K6X3|FTSX|BH3601 from Bacillus halodurans (298 aa), FASTA scores: opt: 290, E(): 5.2e-11, (22.75% identity in 299 aa overlap); etc. BELONGS TO THE FTSX FAMILY.	X2BMM1,Q7TX91	No									X2BMM1,Q7TX91										
NC_002945.3	Mycobrowser_v4	CDS	3429315	3430451	.	-	0	Mb3132c	prfB		PROBABLE PEPTIDE CHAIN RELEASE FACTOR 2 PRFB (RF-2)	Mb3132c, prfB, len: 378 aa. Equivalent to Rv3105c,len: 378 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 378 aa overlap). Probable prfB,peptide chain release factor 2, equivalent to O32885|RF2_MYCLE|ML0667|MLCB1779.24c from Mycobacterium leprae, FASTA scores: opt: 2197, E(): 1.8e-126, (90.05% identity in 372 aa overlap); and also similar to other peptide chain release factors e.g. Q9L1S3|PRFB from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1674,E(): 1.2e-94, (69.3% identity in 365 aa overlap); O67695|RF2_AQUAE|PRFB|AQ_1840 from Aquifex aeolicus (373 aa), FASTA scores: opt: 1082, E(): 1.3e-58, (44.45% identity in 369 aa overlap); P28367|RF2_BACSU from B. subtilis (366 aa), FASTA scores: opt: 1030, E(): 1.9e-55,(44.0% identity in 359 aa overlap); etc. Also related to Q10605|MTCY373.19|RF1_MYCTU|Rv1299|MT1338 peptide chain release factor 1 (rf-1) (357 aa), FASTA scores: opt: 646,E(): 1.1e-34, (38.6% identity in 350 aa overlap). Contains prokaryotic-type class I peptide chain release factors signature (PS00745). BELONGS TO THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY.	X2BMC1,P66027	No									X2BMC1,P66027										
NC_002945.3	Mycobrowser_v4	CDS	3448747	3450138	.	-	0	Mb3154c	tgs1		triacylglycerol synthase (diacylglycerol acyltransferase) tgs1	Mb3154c, -, len: 463 aa. Equivalent to Rv3130c,len: 463 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 463 aa overlap). Conserved hypothetical protein, similar to several other hypothetical Mycobacterium tuberculosis strain H37Rv proteins e.g. O06795|YH60_MYCTU|Rv1760|MTCY28.26 HYPOTHETICAL 54.1 KDA PROTEIN (502 aa), FASTA scores: opt: 586, E(): 9.8e-29, (28.95% identity in 463 aa overlap).	X2BMP4,P0A651	No	lipid metabolism								X2BMP4,P0A651					Rv3130c		Rv3130c			
NC_002945.3	Mycobrowser_v4	CDS	3435719	3436231	.	+	0	Mb3138	moaC1		PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C MOAC1	Mb3138, moaC1, len: 170 aa. Equivalent to Rv3111,len: 170 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 170 aa overlap). Probable moaC1,molybdopterin cofactor biosynthesis protein, highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa), FASTA scores: opt: 576, E(): 2.2e-29,(62.1% identity in 153 aa overlap); Q9ZFA6|MOAC from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (159 aa), FASTA scores: opt: 541, E(): 3.4e-27, (59.85% identity in 157 aa overlap); BAB48171|MLR0616 from Rhizobium loti (Mesorhizobium loti) (160 aa), FASTA scores: opt: 531, E(): 1.5e-26, (58.75% identity in 160 aa overlap); P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa), FASTA scores: opt: 527, E(): 2.6e-26, (58.5% identity in 159 aa overlap); etc. Also highly similar to O53376|MOAC3|Rv3324c|MTV016.24c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 3 from Mycobacterium tuberculosis (177 aa), FASTA scores: opt: 738, E(): 1.7e-39, (71.5% identity in 165 aa overlap); AAK47767|MT3425 MOLYBDOPTERIN COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis strain CDC1551 (184 aa), FASTA scores: opt: 734, E(): 3.1e-39, (71.8% identity in 163 aa overlap); and Rv0864|MOAC2|MTV043.57 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 2 (167 aa). Note that previously known as moaC.	X2BMM8,P0A5K5	No									X2BMM8,P0A5K5	P0A5K5									
NC_002945.3	Mycobrowser_v4	CDS	3430555	3431925	.	+	0	Mb3133	fprA		nadph:adrenodoxin oxidoreductase fpra (nadph-ferredoxin reductase)	Mb3133, fprA, len: 456 aa. Equivalent to Rv3106,len: 456 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 456 aa overlap). Probable fprA,NADPH:adrenodoxin oxidoreductase (EC 1.18.1.2), equivalent to O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae (456 aa), FASTA scores: opt: 2505, E(): 1.2e-142,(81,05% identity in 459 aa overlap); also similar to other NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from Deinococcus radiodurans (479 aa), FASTA scores: opt: 1331,E(): 2.6e-72, (48.9% identity in 454 aa overlap); Q9RK35|SCF15.02 from Streptomyces coelicolor (454 aa),FASTA scores: opt: 1102, E(): 1.3e-58, (41.35% identity in 462 aa overlap); P82861 from Salvelinus fontinalis (Brook trout) (498 aa), FASTA scores: opt: 827, E(): 4e-42,(41.3% identity in 460 aa overlap); Q9V3T9|ADRO_DROME from Drosophila melanogaster (Fruit fly) (466 aa), FASTA scores: opt: 790, E(): 6.3e-40, (39.45% identity in 459 aa overlap); etc. Also similar to Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium tuberculosis strain H37Rv (575 aa), FASTA scores: opt: 894, E(): 4.4e-46, (42.05% identity in 459 aa overlap).	Q7TX87	No	intermediary metabolism and respiration							IPR016040,IPR021163	Q7TX87	A0A1R3Y343				Rv3106		Rv3106			
NC_002945.3	Mycobrowser_v4	CDS	3431926	3433509	.	-	0	Mb3134c	agpS		POSSIBLE ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE AGPS (ALKYL-DHAP SYNTHASE) (ALKYLGLYCERONE-PHOSPHATE SYNTHASE)	Mb3134c, agpS, len: 527 aa. Equivalent to Rv3107c,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 527 aa overlap). Possible agpS,alkyl-dihydroxyacetonephosphate synthase (EC 2.5.1.26),similar to others and some various enzymes e.g. AAK46595|MT2311 PUTATIVE ALKYL-DIHYDROXYACETONEPHOSPHATE SYNTHASE from Mycobacterium tuberculosis strain CDC1551 (529 aa), FASTA scores: opt: 1052, E(): 2.1e-58, (37.1% identity in 542 aa overlap); Q9RJ97|SCF91.28c PUTATIVE FLAVOPROTEIN from Streptomyces coelicolor (530 aa), FASTA scores: opt: 972, E(): 2.2e-53, (36.2% identity in 544 aa overlap); O96759|ADAS_DICDI ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE (EC 2.5.1.26) from Dictyostelium discoideum (Slime mold) (611 aa), FASTA scores: opt: 617, E(): 4.5e-31, (33.95% identity in 480 aa overlap); O97157|ADAS_TRYBB ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE from Trypanosoma brucei (613 aa), FASTA scores: opt: 567,E(): 6.2e-28, (29.15% identity in 521 aa overlap); etc. Also similar to O53525|Rv2251|MTV022.01 HYPOTHETICAL 49.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (475 aa), FASTA scores: opt: 1019, E(): 2.3e-56, (38.6% identity in 487 aa overlap). BELONGS TO THE FAD-BINDING OXIDOREDUCTASE/TRANSFERASE FAMILY 4. COFACTOR: FAD (BY SIMILARITY).	Q7TX86	No								IPR004113,IPR006094,IPR016164,IPR016166,IPR016167,IPR016169,IPR016171,IPR025650	Q7TX86	A0A1R3Y363									
NC_002945.3	Mycobrowser_v4	CDS	3434197	3435276	.	+	0	Mb3136	moaA1		PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1	Mb3136, moaA1, len: 359 aa. Equivalent to Rv3109,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 359 aa overlap). Probable moaA1,molybdenum cofactor biosynthesis protein, highly similar to others e.g. P39757|MOAA_BACSU|NARA|NARAB from Bacillus subtilis (341 aa), FASTA scores: opt: 810, E(): 6.2e-44,(39.75% identity in 327 aa overlap); O67929|MOAA_AQUAE|AQ_2183 from Aquifex aeolicus (320 aa),FASTA scores: opt: 794, E(): 6e-43, (40.55% identity in 323 aa overlap); Q9ZIM6|MOAA_STACA from Staphylococcus carnosus (340 aa), FASTA scores: opt: 783, E(): 3.2e-42,(38.65% identity in 326 aa overlap); etc. Also highly similar to O53143|MOAA3|MOA3_MYCTU|MT3427 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 3 from Mycobacterium tuberculosis strain F4 (378 aa), FASTA scores: opt: 1762,E(): 4.7e-104, (74.3% identity in 350 aa overlap); and similar to O53881|MOA2_MYCTU|MOAA2|Rv0869c|MT0892|MTV043.62 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 2 from Mycobacterium tuberculosis strain H37Rv (360 aa), FASTA scores: opt: 657, E(): 3e-34, (36.55% identity in 309 aa overlap). BELONGS TO THE MOAA / NIFB / PQQE FAMILY. Note that previously known as moaA.	X2BNE4,Q7TX84	No									X2BNE4,Q7TX84	Q7TX84									
NC_002945.3	Mycobrowser_v4	CDS	3435327	3435722	.	+	0	Mb3137	moaB1		PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB1 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD)	Mb3137, moaB1, len: 131 aa. Equivalent to Rv3110,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Probable moaB1,pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),similar to others e.g. P73790|SSL2296 from Synechocystis sp. strain PCC 6803 (96 aa), FASTA scores: opt: 195, E(): 6.2e-07, (35.4% identity in 96 aa overlap); Q9PAB4|PHS_XYLFA|XF2604 from Xylella fastidiosa (116 aa),FASTA scores: opt: 187, E(): 2.6e-06, (36.25% identity in 102 aa overlap); AAK42360|Q97WM6|PHS_SULSO|SSO2187 from Sulfolobus solfataricus (114 aa), FASTA scores: opt: 177,E(): 1.3e-05, (34.6% identity in 78 aa overlap); etc. Also highly similar to AAK47768|MT3426 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis CDC1551 (124 aa), FASTA scores: opt: 383, E(): 7.7e-20, (50.0% identity in 110 aa overlap). BELONGS TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Note that previously known as moaB.	Q7TTP4	No								IPR001533	Q7TTP4	A0A1R3Y357									
NC_002945.3	Mycobrowser_v4	CDS	3439323	3440492	.	+	0	Mb3143	moeB2		PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB2 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE)	Mb3143, moeB2, len: 389 aa. Equivalent to Rv3116,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 389 aa overlap). Probable moeB2,molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 1433, E(): 8e-80, (57.8% identity in 384 aa overlap). Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1562, E(): 1.1e-87, (58.15% identity in 380 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1311, E(): 2.1e-72, (52.4% identity in 395 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1238, E(): 5.7e-68, (51.4% identity in 393 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1212,E(): 2.2e-66, (46.5% identity in 398 aa overlap); etc. Also highly similar to O05860|MTCY07D11.20|MOEB1|Rv3206c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis strain H37Rv (392 aa), FASTA scores: opt: 1445, E(): 1.5e-80, (56.25% identity in 400 aa overlap). BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeB.	Q7TX81	No								IPR000594,IPR001763,IPR007901,IPR009036,IPR016040	Q7TX81	A0A1R3Y352									
NC_002945.3	Mycobrowser_v4	CDS	3456903	3458045	.	+	0	Mb3160	PPE51		ppe family protein ppe51	Mb3160, PPE51, len: 380 aa. Equivalent to Rv3136,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 380 aa overlap). Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family,similar to Q9AGF0|Ov2770c Rv2770c-LIKE PROTEIN from M. microti (397 aa), FASTA scores: opt: 917, E(): 9e-41,(46.15% identity in 388 aa overlap); O33312|Rv2770c|MTV002.35c, MTV002_36, MTCI125_26,MTCY10G2_10, MTCI364_8, MTV049_28, MTV049_29, etc. TBparse score is 0.923.	Q7TX66	No								IPR000030,IPR022171	Q7TX66	A0A1R3Y3W9									
NC_002945.3	Mycobrowser_v4	CDS	3440521	3441483	.	+	0	Mb3144	cyp141		probable cytochrome p450 141 cyp141	Mb3144, cysA3, len: 320 aa. Equivalent to 5' end of Rv3117 and 3' end of Rv3121, len: 277 aa and 400 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 255 aa overlap and 56.7% identity in 150 aa overlap). Probable cysA3, thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1442, E(): 1.7e-84, (75.55% identity in 274 aa overlap); Q9RXT9DR0217|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1046,E(): 2.6e-59, (53.8% identity in 275 aa overlap); Q9HMT7|TSSA|VNG2393G from Halobacterium sp. strain NRC-1 (293 aa), FASTA scores: opt: 1030, E(): 2.7e-58, (56.1% identity in 278 aa overlap); Q9Y8N8|APE2595 from Aeropyrum pernix (218 aa), FASTA scores: opt: 808, E(): 2.7e-44,(53.5% identity in 215 aa overlap); etc. Identical second copy present as Rv0815c|AL022004|MTV043.07c|MT0837|O05793|cysA2 (277 aa) (100.0% identity in 277 aa overlap). Also shows some similarity to P96888|THT2_MYCTU|SSEA|Rv3283|MT3382|MTCY71.23 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (297 aa), FASTA scores: opt: 955, E(): 1.6e-53, (50.2% identity in 271 aa overlap); and Q59570|THT3_MYCTU|SSEB|Rv2291|MT2348|MTCY339.19c PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (284 aa), FASTA scores: E(): 1.4e-14, (26.7% identity in 292 aa overlap). Contains rhodanese active site and C-terminal signatures (PS00380, PS00683). BELONGS TO THE RHODANESE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv.	X2BMN5,Q7TX80	No									X2BMN5,Q7TX80	Q7TX80									
NC_002945.3	Mycobrowser_v4	CDS	3443278	3444147	.	+	0	Mb3147	moar1		transcriptional regulatory protein moar1	Mb3147, -, len: 289 aa. Equivalent to Rv3124, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable transcriptional regulatory protein, similar to many Streptomyces and Mycobacterium tuberculosis regulatory proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15 from Mycobacterium tuberculosis strain H37Rv (388 aa),FASTA scores: opt: 963, E(): 2e-56, (55.15% identity in 252 aa overlap); O53145 from Mycobacterium tuberculosis (381 aa); P71484|EMBR from Mycobacterium avium (384 aa),FASTA scores: opt: 859, E(): 1.5e-49, (52.2% identity in 249 aa overlap); Q9XCC3|TYLT from Streptomyces fradiae (404 aa), FASTA scores: opt: 462, E(): 3.1e-23, (35.05% identity in 254 aa overlap); Q9XCC4|TYLS from Streptomyces fradiae (277 aa), FASTA scores: opt: 456, E(): 5.6e-23,(33.45% identity in 269 aa overlap); etc. Start chosen by similarity, alternative possible (see AAK47548 from Mycobacterium tuberculosis strain CDC1551, longer N-terminus (311 aa)).	Q7TX77	No	regulatory proteins							IPR001867,IPR005158,IPR011990,IPR011991,IPR016032	Q7TX77	A0A1R3Y367				Rv3124		Rv3124			
NC_002945.3	Mycobrowser_v4	CDS	3444248	3445423	.	-	0	Mb3148c	PPE49		ppe family protein ppe49	Mb3148c, PPE49, len: 391 aa. Equivalent to Rv3125c,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 391 aa overlap). Member of the M. tuberculosis PPE family, similar to other e.g. P95247|Rv2352c|MTCY98.21c (391 aa), FASTA scores: opt: 1576, E(): 3.8e-72, (62.55% identity in 398 aa overlap),MTCY98.0029c, MTCY03A2.22c, MTCY10G2.10, MTCY02B10.25c,MTCI364.08, M TCY21C12.09c, MTCY48.17.	Q7TX76	No								IPR000030,IPR022171	Q7TX76	A0A1R3Y376									
NC_002945.3	Mycobrowser_v4	CDS	3451301	3453037	.	-	0	Mb3156c	devS		TWO COMPONENT SENSOR HISTIDINE KINASE DEVS	Mb3156c, devS, len: 578 aa. Equivalent to Rv3132c,len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 578 aa overlap). devS, membrane-bound two component sensor histidine kinase (EC 2.7.3.-) (see citations below; dev for Differentially Expressed in Virulent strain), similar to others two component sensors e.g. Q9RI43|SCJ12.15c PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (585 aa), FASTA scores: opt: 1305,E(): 2.5e-69, (41.35% identity in 573 aa overlap); Q9ZBY4|SCD78.15 PUTATIVE TWO COMPONENT SENSOR from Streptomyces coelicolor (560 aa), FASTA scores: opt: 1194,E(): 8.1e-63, (41.05% identity in 558 aa overlap); O85371|CPRS TWO COMPONENT REGULATOR from Rhodococcus sp (563 aa), FASTA scores: opt: 803, E(): 8.3e-40, (38.4% identity in 552 aa overlap); Q9L094|SCC24.23 PUTATIVE TWO-COMPONENT SENSOR HISTIDINE KINASE from Streptomyces coelicolor (similarity only in C-terminus for this one); etc. Also highly similar to mycobacterium O53473|Rv2027c|MTV018.14c PUTATIVE MEMBRANE PROTEIN (573 aa), FASTA scores: opt: 2333, E(): 7.6e-130, (61.45% identity in 576 aa overlap).	Q7TX69	No								IPR003018,IPR003594,IPR005467,IPR011712	Q7TX69	A0A1R3Y364									
NC_002945.3	Mycobrowser_v4	CDS	3465197	3466426	.	-	0	Mb3168c	PPE52		ppe family protein ppe52	Mb3168c, PPE52, len: 409 aa. Equivalent to Rv3144c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 409 aa overlap). Member of the M. tuberculosis PPE family, Gly-, Ala-rich, similar to others e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1007, E(): 5.2e-35, (56.2% identity in 306 aa overlap); and MTV014_3, MTCY6G11_5, MTCY98.0034c,MTCY31.06c, MTCY48.17, MTCY98.0029c, MTCY03C7.17c, etc.	Q7TX58	No								IPR000030	Q7TX58	A0A1R3Y535									
NC_002945.3	Mycobrowser_v4	CDS	3453034	3453687	.	-	0	Mb3157c	devR		TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY)	Mb3157c, devR, len: 217 aa. Equivalent to Rv3133c,len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 217 aa overlap). devR, two component transcriptional regulator (see first citation below; dev for Differentially Expressed in Virulent strain), highly similar to several e.g. O85372|CPRR TWO COMPONENT REGULATOR from Rhodococcus sp. (212 aa), FASTA scores: opt: 868, E(): 6.2e-46, (65.05% identity in 206 aa overlap); Q9RI42|SCJ12.16c PUTATIVE LUXR FAMILY TWO-COMPONENT RESPONSE REGULATOR from Streptomyces coelicolor (233 aa), FASTA scores: opt: 849, E(): 9.7e-45,(60.55% identity in 218 aa overlap); Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 835, E(): 6.5e-44, (61.55% identity in 208 aa overlap); and similar to others. Contains bacterial regulatory proteins, LuxR family signature (PS00622) near C-terminus as seen in bvgA, comA, dctR, degU, evgA, fimZ,fixJ, gacA, glpR, narL, narP, nodW, rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS.	I3NIF5	No								IPR000792,IPR001789,IPR011006,IPR011991,IPR016032	I3NIF5	A0A1R3Y377									
NC_002945.3	Mycobrowser_v4	CDS	3467186	3467740	.	+	0	Mb3170	nuoB		PROBABLE NADH DEHYDROGENASE I (CHAIN B) NUOB (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN B)	Mb3170, nuoB, len: 184 aa. Equivalent to Rv3146,len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Probable nuoB, NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. Q9XAQ5|NUOB from Streptomyces coelicolor (184 aa),FASTA scores: opt: 989, E(): 1.4e-56, (78.25% identity in 184 aa overlap); Q56218|NQO6_THETH|NQO6 from Thermus aquaticus (subsp. thermophilus) (181 aa), FASTA scores: opt: 720, E(): 2.6e-39, (64.45% identity in 152 aa overlap); Q9RU87|DR1505 from Deinococcus radiodurans (181 aa), FASTA scores: opt: 719, E(): 3e-39, (62.6% identity in 155 aa overlap); etc. BELONGS TO THE COMPLEX I 20 KDA SUBUNIT FAMILY. MAY CONTAIN AN IRON-SULFUR 4FE-4S CLUSTER. TBparse score is 0.912.	X2BNJ1,P65576	No	intermediary metabolism and respiration								X2BNJ1,P65576	P65576				Rv3146		Rv3146			
NC_002945.3	Mycobrowser_v4	CDS	3477033	3477332	.	+	0	Mb3179	nuoK		PROBABLE NADH DEHYDROGENASE I (CHAIN K) NUOK (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN K)	Mb3179, nuoK, len: 99 aa. Equivalent to Rv3155,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Probable nuoK,integral membrane NADH dehydrogenase I, chain K (EC 1.6.5.3), similar to others e.g. Q9XAR4|NUOK from Streptomyces coelicolor (99 aa), FASTA scores: opt: 509,E(): 2.7e-31, (78.55% identity in 98 aa overlap); Q56226|NQOB_THETH|NQO11 from Thermus aquaticus (subsp. thermophilus) (95 aa), BLAST scores: initn: 298, init1: 180, bits: 85.7, FASTA scores: opt: 313, E(): 9.4e-17,(53.7% identity in 95 aa overlap); Q9RU97|DR1495 from Deinococcus radiodurans (103 aa), FASTA scores: opt: 309,E(): 2e-16, (52.0% identity in 100 aa overlap); etc. But also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES CHAIN 4L e.g. Q9MUL4|NULC_MESVI|NDHE from Mesostigma viride (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) (101 aa), FASTA scores: opt: 280, E(): 2.8e-14, (40.6% identity in 101 aa overlap); and P06261|NULC_TOBAC|NDHE|NDH4L from Nicotiana tabacum (Common tobacco) (101 aa), FASTA scores: opt: 259,E(): 1e-12, (43.0% identity in 93 aa overlap). SIMILAR TO POLYPEPTIDE 4L OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIA.	X2BN81,P65566	No	intermediary metabolism and respiration								X2BN81,P65566	P65566				Rv3155		Rv3155			
NC_002945.3	Mycobrowser_v4	CDS	3455106	3456251	.	+	0	Mb3159	PPE50		ppe family protein ppe50	Mb3159, PPE50, len: 381 aa. Similar to 5' end of Rv3135, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv, (88.5% identity in 131 aa overlap). Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to P95190|Rv3136|MTCY03A2.22c (380 aa),FASTA scores: opt: 494, E(): 6.7e-25, (57.25% identity in 131 aa overlap) (next ORF downstream), MTY21C12_9,MTCY3C7_24, MTCI125_27, MTV049_12, MTV049_9, MTV049_11 ,MTCY274_24 etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 1337 bp insertion leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa).	Q7TX67	No								IPR000030,IPR022171	Q7TX67	A0A1R3Y534									
NC_002945.3	Mycobrowser_v4	CDS	3459304	3460392	.	+	0	Mb3162	pflA		PROBABLE PYRUVATE FORMATE LYASE ACTIVATING PROTEIN PFLA (FORMATE ACETYLTRANSFERASE ACTIVATING ENZYME) ([PYRUVATE FORMATE-LYASE] ACTIVATING ENZYME)	Mb3162, pflA, len: 362 aa. Equivalent to Rv3138,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 362 aa overlap). Probable pflA,pyruvate formate lyase activating protein (EC 1.97.1.4),similar to other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa), FASTA scores: opt: 926, E(): 1.1e-52,(39.95% identity in 343 aa overlap); O27446|MTH1395 from Methanobacterium thermoautotrophicum (335 aa), FASTA scores: opt: 909, E(): 1.3e-51, (42.2% identity in 327 aa overlap); O28939|AF1330 from Archaeoglobus fulgidus (336 aa), FASTA scores: opt: 884, E(): 5.6e-50, (42.0% identity in 319 aa overlap); etc. Also similar to O50099|PH1391 HYPOTHETICAL 40.2 KDA PROTEIN from Pyrococcus horikoshii (348 aa), FASTA scores: opt: 934, E(): 3.3e-53, (40.5% identity in 343 aa overlap); and other hypothetical proteins. TBparse score is 0.881.	Q7TX64	No	intermediary metabolism and respiration							IPR006638,IPR007197,IPR016431,IPR027596	Q7TX64	A0A1R3Y372				Rv3138		Rv3138			
NC_002945.3	Mycobrowser_v4	CDS	3460472	3461878	.	+	0	Mb3163	fadE24		PROBABLE ACYL-CoA DEHYDROGENASE FADE24	Mb3163, fadE24, len: 468 aa. Equivalent to Rv3139,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable fadE24,acyl-CoA dehydrogenase (1.3.99.-), equivalent to O32890|MLCB1779.30|FADE24|ML0661 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (465 aa), FASTA scores: opt: 2587, E(): 4e-153, (83.6% identity in 464 aa overlap). Similar to other e.g. Q9HUH0|PA4995 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 1139,E(): 2.8e-63, (45.3% identity in 426 aa overlap); Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa),FASTA scores: opt: 603, E(): 4.7e-30, (30.3% identity in 366 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 601, E(): 6.3e-30,(32.25% identity in 363 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073) near C-terminus. BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.881.	Q7TX63	No								IPR006089,IPR006091,IPR009075,IPR009100,IPR013786	Q7TX63	A0A1R3Y393									
NC_002945.3	Mycobrowser_v4	CDS	3461899	3463104	.	+	0	Mb3164	fadE23		PROBABLE ACYL-CoA DEHYDROGENASE FADE23	Mb3164, fadE23, len: 401 aa. Equivalent to Rv3140,len: 401 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 401 aa overlap). Probable fadE23,acyl-CoA dehydrogenase (1.3.99.-) (see citation below),equivalent to O32891|MLCB1779.31|FADE23|ML0660 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (400 aa),FASTA scores: opt: 2307, E(): 3e-136, (89.5% identity in 401 aa overlap). Also similar to others e.g. Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 1558, E(): 1.2e-89, (61.0% identity in 400 aa overlap); O31251 from Acinetobacter sp. ADP1 (401 aa), FASTA scores: opt: 1509, E(): 1.3e-86, (58.2% identity in 402 aa overlap); Q9K6D1|ACDA OR BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 612, E(): 8.4e-31, (38.2% identity in 293 aa overlap); Q9AHX9|FADFX from Pseudomonas putida (375 aa), FASTA scores: opt: 584, E(): 4.6e-29,(32.7% identity in 379 aa overlap); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.890.	Q7TX62	No								IPR006091,IPR009075,IPR009100	Q7TX62	A0A1R3Y382									
NC_002945.3	Mycobrowser_v4	CDS	3463204	3464175	.	+	0	Mb3165	fadB4		PROBABLE NADPH QUINONE OXIDOREDUCTASE FADB4 (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN)	Mb3165, fadB4, len: 323 aa. Equivalent to Rv3141,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Probable fadB4,quinone oxidoreductase (EC 1.6.5.5), showing strong similarity to variety of quinone oxidoreductases and domains in polyketide and fatty acid synthases e.g. Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35,(39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32,(40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3% identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23,(34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110 QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55% identity in 322 aa overlap); etc. Also similar to Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (325 aa), FASTA scores: opt: 673,E(): 7.2e-32, (40.2% identity in 326 aa overlap); and Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (332 aa), FASTA scores: opt: 623,E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also resembles Mycobacterium tuberculosis proteins P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03,MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. TBparse score is 0.904. Thought to be differentially expressed within host cells (see first citation below).	Q7TX61	No								IPR002085,IPR011032,IPR013149,IPR013154,IPR016040	Q7TX61	A0A1R3Y374									
NC_002945.3	Mycobrowser_v4	CDS	4030869	4031183	.	+	0	Mb3676	PE_PGRS60		pe-pgrs family-related protein pe_pgrs60	Mb3676, PE_PGRS60, len: 104 aa. Equivalent to Rv3652, len: 104 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 104 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar at N-terminal end with many e.g. P56877|Y278_MYCTU|Rv0278c|MTV035.06c (957 aa) FASTA scores: opt: 242, E(): 3e-09, (77.35% identity in 53 aa overlap). Originally annotated as the first part of a PE-PGRS family protein (Rv3653/PE_PGRS61 being the second part) but more similar to a PE family protein. Length extended since first submission (+50 aa).	Q7TW11	No								IPR000084	Q7TW11	A0A1R3Y4T4									
NC_002945.3	Mycobrowser_v4	CDS	3466791	3467177	.	+	0	Mb3169	nuoA		PROBABLE NADH DEHYDROGENASE I (CHAIN A) NUOA (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN A)	Mb3169, nuoA, len: 128 aa. Equivalent to Rv3145,len: 128 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 128 aa overlap). Probable nuoA,integral membrane NADH dehydrogenase, chain A (EC 1.6.5.3), similar to others e.g. Q9XAQ4|NUOA from Streptomyces coelicolor (119 aa), FASTA scores: opt: 405,E(): 5.4e-20, (68.75% identity in 128 aa overlap); Q9RU86|DR1506 from Deinococcus radiodurans (160 aa), FASTA scores: opt: 327, E(): 9e-15, (40.3% identity in 124 aa overlap); BAB47039|NDHC from Triticum aestivum (Wheat),FASTA scores: opt: 273, E(): 2.6e-11, (38.1% identity in 126 aa overlap); etc. Also similar to a NADH-PLASTOQUINONE OXIDOREDUCTASES e.g. P26303|NU3C_WHEAT|NDHC from Triticum aestivum (Wheat) (120 aa), FASTA scores: opt: 273, E(): 2.6e-1, (38.1% identity in 126 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 3 FAMILY. TBparse score is 0.895.	X2BN70,P65564	No	intermediary metabolism and respiration								X2BN70,P65564	P65564				Rv3145		Rv3145			
NC_002945.3	Mycobrowser_v4	CDS	3467737	3468447	.	+	0	Mb3171	nuoC		PROBABLE NADH DEHYDROGENASE I (CHAIN C) NUOC (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN C)	Mb3171, nuoC, len: 236 aa. Equivalent to Rv3147,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Probable nuoC, NADH dehydrogenase, chain C (EC 1.6.5.3), similar to others e.g. Q9XAQ6|NUOC from Streptomyces coelicolor (251 aa),FASTA scores: opt: 1113, E(): 2.6e-64, (67.35% identity in 236 aa overlap); Q9A6X2|CC1954 from Caulobacter crescentus (197 aa), FASTA scores: opt: 351, E(): 1.6e-15, (41.65% identity in 132 aa overlap); BAB48757|MLL1369 from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 347, E(): 3e-15, (42.4% identity in 132 aa overlap); etc. Also similar to Q9UUU0|NUGM NUGM PROTEIN PRECURSOR (EC 1.6.99.3) from Yarrowia lipolytica (Candida lipolytica) (281 aa), FASTA scores: opt: 356, E(): 1.1e-15, (34.55% identity in 162 aa overlap). Also similar to MTCY251.05, FASTA score: E():4.9e-05. Equivalent to AAK47574 from Mycobacterium tuberculosis strain CDC1551 but longer 26 aa. BELONGS TO THE COMPLEX I 30 KDA SUBUNIT FAMILY. TBparse score is 0.893.	X2BME6,P65572	No	intermediary metabolism and respiration								X2BME6,P65572	P65572				Rv3147		Rv3147			
NC_002945.3	Mycobrowser_v4	CDS	3468447	3469769	.	+	0	Mb3172	nuoD		PROBABLE NADH DEHYDROGENASE I (CHAIN D) NUOD (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN D)	Mb3172, nuoD, len: 440 aa. Equivalent to Rv3148,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable nuoD, NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa),FASTA scores: opt: 2198, E(): 1e-131, (73.9% identity in 429 aa overlap); P15689|NUCM_PARTE from Paramecium tetraurelia (400 aa), FASTA scores: opt: 922, E(): 5.8e-51, (38.5% identity in 408 aa overlap); Q9RU89|NUOD_DEIRA|DR1503 from Deinococcus radiodurans (401 aa), FASTA scores: opt: 922, E(): 5.8e-51, (47.75% identity in 404 aa overlap); etc. Equivalent to AAK47575 from Mycobacterium tuberculosis strain CDC1551 but longer 42 aa. Contains helix-turn-helix motif at aa 340-361. BELONGS TO THE COMPLEX I 49 KDA SUBUNIT FAMILY.	X2BMR2,P65570	No	intermediary metabolism and respiration								X2BMR2,P65570	P65570				Rv3148		Rv3148			
NC_002945.3	Mycobrowser_v4	CDS	3469766	3470524	.	+	0	Mb3173	nuoE		PROBABLE NADH DEHYDROGENASE I (CHAIN E) NUOE (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN E)	Mb3173, nuoE, len: 252 aa. Equivalent to Rv3149,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable nuoE, NADH dehydrogenase, chain E (EC 1.6.5.3), similar to others e.g. Q9XAQ8|NUOE from Streptomyces coelicolor (290 aa),FASTA scores: opt: 1002, E(): 5.7e-55, (69.5% identity in 213 aa overlap); P40915|NUHM_NEUCR|NUO-24 from Neurospora crassa (263 aa), FASTA scores: opt: 412, E(): 1.9e-18,(38055% identity in 192 aa overlap); P19234|NUHM_RAT from Rattus norvegicus (Rat) (241 aa), FASTA scores: opt: 410,E(): 2.4e-18, (23.9% identity in 237 aa overlap); etc. BELONGS TO THE COMPLEX I 24 KDA SUBUNIT FAMILY. BINDS A 2FE-2S CLUSTER (POTENTIAL).	X2BMR1,P65574	No	intermediary metabolism and respiration								X2BMR1,P65574	P65574				Rv3149		Rv3149			
NC_002945.3	Mycobrowser_v4	CDS	3470521	3471858	.	+	0	Mb3174	nuoF		PROBABLE NADH DEHYDROGENASE I (CHAIN F) NUOF (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN F)	Mb3174, nuoF, len: 445 aa. Equivalent to Rv3150,len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 445 aa overlap). Probable nuoF, NADH dehydrogenase, chain F (EC 1.6.5.3), similar to others e.g. Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449 aa), FASTA scores: opt: 2314, E(): 3.5e-139, (76.25% identity in 434 aa overlap); NUF2_RHIME from Rhizobium meliloti (421 aa), FASTA scores: opt: 1545, E(): 1.8e-90,(53.1% identity in 424 aa overlap); Q9RU92|DR1500 from Deinococcus radiodurans (444 aa), FASTA scores: opt: 1445,E(): 4.1e-84, (52.9% identity in 427 aa overlap); etc. Contains respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2 (PS00645). BELONGS TO THE COMPLEX I 51 KDA SUBUNIT FAMILY. COFACTOR: FMN AND ONE 4FE-4S CLUSTER (PROBABLE).	X2BN76,P65568	No	intermediary metabolism and respiration								X2BN76,P65568	P65568				Rv3150		Rv3150			
NC_002945.3	Mycobrowser_v4	CDS	3471855	3474275	.	+	0	Mb3175	nuoG		PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G)	Mb3175, nuoG, len: 806 aa. Equivalent to Rv3151,len: 806 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 806 aa overlap). Probable nuoG, NADH dehydrogenase I, chain G (EC 1.6.5.3), similar to others e.g. Q9XAR0|NUOG_STRCO from Streptomyces coelicolor (843 aa), FASTA scores: opt: 1968 ,E(): 5.2e-107, (62.45% identity in 818 aa overlap); P56914|NUG2_RHIME from Rhizobium meliloti (853 aa), FASTA scores: opt: 964, E(): 1.6e-48, (30.6% identity in 840 aa overlap); etc. But also similarity with other proteins e.g. P77908|FDHA FORMATE DEHYDROGENASE, ALPHA SUBUNIT (EC 1.2.1.43) (FORMATE DEHYDROGENASE [NADP+]) from Moorella thermoacetica (Clostridium thermoaceticum) (893 aa), FASTA scores: opt: 928, E(): 2e-46, (28.65% identity in 865 aa overlap); and Q9UUU3|NUAM NUAM PROTEIN PRECURSOR (EC 1.6.99.3) from Yarrowia lipolytica (Candida lipolytica) (728 aa), FASTA scores: opt: 894, E(): 1.7e-44, (31.95% identity in 676 aa overlap). Equivalent to AAK47578 from Mycobacterium tuberculosis strain CDC1551 but longer 15 aa. Contains respiratory-chain NADH dehydrogenase 75 kDa subunit signature 2 (PS00642). BELONGS TO THE COMPLEX I 75 KDA SUBUNIT FAMILY. COFACTOR: MAY BIND TWO 4FE-4S CLUSTER AND ONE 2FE-2S CLUSTER. TBparse score is 0.887.	X2BNJ5,P59962	No	intermediary metabolism and respiration								X2BNJ5,P59962	P59962				Rv3151		Rv3151			
NC_002945.3	Mycobrowser_v4	CDS	3474391	3475623	.	+	0	Mb3176	nuoH		PROBABLE NADH DEHYDROGENASE I (CHAIN H) NUOH (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN H)	Mb3176, nuoH, len: 410 aa. Equivalent to Rv3152,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 410 aa overlap). Probable nuoH,integral membrane NADH dehydrogenase I, chain H (EC 1.6.5.3), similar to others e.g. Q9XAR1 Q9XAR1|NUOH from Streptomyces coelicolor (467 aa), FASTA scores: opt: 1630,E(): 3.4e-90, (58.35% identity in 413 aa overlap); Q9RU94|DR1498 from Deinococcus radiodurans (397 aa), FASTA scores: opt: 1081, E(): 2e-57, (45.5% identity in 391 aa overlap); Q9ZCF7|NUOH_RICPR|RP796 from Rickettsia prowazekii (339 aa), FASTA scores: opt: 976, E(): 3.4e-51,(46.2% identity in 329 aa overlap); etc. Contains respiratory-chain NADH dehydrogenase subunit 1 signature 2 (PS00668). Some similarity to MTCY251.02 (FASTA score: E(): 1.2e-07). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY.	X2BME9,P65562	No	intermediary metabolism and respiration								X2BME9,P65562	P65562				Rv3152		Rv3152			
NC_002945.3	Mycobrowser_v4	CDS	3498133	3498615	.	-	0	Mb3197c	Mb3197c		HYPOTHETICAL PROTEIN	Mb3197c, -, len: 160 aa. Equivalent to Rv3172c,len: 160 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 160 aa overlap). Hypothetical unknown protein.	Q7TX40,A0A1R3Y3C1	No	conserved hypotheticals			A0A1R3Y3C1					Q7TX40					Rv3172c		Rv3172c			
NC_002945.3	Mycobrowser_v4	CDS	3475616	3476251	.	+	0	Mb3177	nuoI		PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN I)	Mb3177, nuoI, len: 211 aa. Equivalent to Rv3153,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). Probable nuoI, NADH dehydrogenase I, chain I (EC 1.6.5.3), similar to others e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211 aa),FASTA scores: opt: 825, E(): 9.3e-44, (70.1% identity in 164 aa overlap); Q56224|NQO9_THETH from Thermus aquaticus (subsp. thermophilus) (182 aa), FASTA scores: opt: 543,E(): 1.8e-26, (50.9% identity in 163 aa overlap); Q9RU95|DR1497 from Deinococcus radiodurans (178 aa), FASTA scores: opt: 527, E(): 1.7e-25, (48.75% identity in 162 aa overlap); etc. Contains two 4Fe-4S ferredoxins,iron-sulfur binding region signatures (PS00198). BELONGS TO THE COMPLEX I 23 KDA SUBUNIT FAMILY. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. COFACTOR: BINDS TWO 4FE-4S CLUSTERS.	X2BMR8,Q7TX57	No	intermediary metabolism and respiration								X2BMR8,Q7TX57	Q7TX57				Rv3153		Rv3153			
NC_002945.3	Mycobrowser_v4	CDS	3476248	3477036	.	+	0	Mb3178	nuoJ		PROBABLE NADH DEHYDROGENASE I (CHAIN J) NUOJ (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN J)	Mb3178, nuoJ, len: 262 aa. Equivalent to Rv3154,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Probable nuoJ,transmembrane NADH dehydrogenase I, chain J (EC 1.6.5.3),similar to others e.g. Q9XAR3|NUOJ from Streptomyces coelicolor (285 aa), FASTA scores: opt: 991, E(): 3.2e-52,(63.7% identity in 243 aa overlap); Q9JX90|NUOJ|NMA0006 from Neisseria meningitidis (serogroup A) (223 aa), FASTA scores: opt: 329, E(): 9.6e-13, (34.85% identity in 175 aa overlap); Q9K1B2|NMB0253 from Neisseria meningitidis (serogroup B) (223 aa), FASTA scores: opt: 326, E(): 1.5e-12, (34.85% identity in 175 aa overlap); etc. But also similarity with Q00243|NU6C_PLEBO|NDH6 NADH-PLASTOQUINONE OXIDOREDUCTASE CHAIN 6 HOMOLOG (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) from Plectonema boryanum (199 aa),FASTA scores: opt: 287, E(): 2.8e-10, (34.35% identity in 195 aa overlap). SIMILAR TO POLYPEPTIDE 6 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIA.	Q7TX56	No	intermediary metabolism and respiration							IPR001457	Q7TX56	A0A1R3Y544				Rv3154		Rv3154			
NC_002945.3	Mycobrowser_v4	CDS	3477343	3479244	.	+	0	Mb3180	nuoL		PROBABLE NADH DEHYDROGENASE I (CHAIN L) NUOL (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN L)	Mb3180, nuoL, len: 633 aa. Equivalent to Rv3156,len: 633 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 633 aa overlap). Probable nuoL,integral membrane NADH dehydrogenase I, chain L (EC 1.6.5.3), similar to others e.g. Q9XAR5|NUOL_STRCO from Streptomyces coelicolor (654 aa), FASTA scores: opt: 2074,E(): 1.1e-111, (61.1% identity in 648 aa overlap); Q56227|NQOC_THETH|NQO12 from Thermus aquaticus (subsp. thermophilus) (606 aa), FASTA scores: opt: 1420, E(): 3.8e-74, (43.35% identity in 630 aa overlap); Q9ZJV6|NUOL|JHP1192 from Helicobacter pylori J99 (Campylobacter pylori J99) (612 aa), FASTA scores: opt: 1279, E(): 4.7e-66, (41.65% identity in 516 aa overlap); etc. Also similar to MTCY251.04 (FASTA score: E(): 1.3e-11) and MTCY03A2.01c (FASTA score: E(): 2.3e-10). SIMILAR TO POLYPEPTIDE 5 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIAL.	Q7TX55	No	intermediary metabolism and respiration							IPR001516,IPR001750,IPR003945,IPR018393	Q7TX55	A0A1R3Y3I0				Rv3156		Rv3156			
NC_002945.3	Mycobrowser_v4	CDS	3479241	3480902	.	+	0	Mb3181	nuoM		PROBABLE NADH DEHYDROGENASE I (CHAIN M) NUOK (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN M)	Mb3181, nuoM, len: 553 aa. Equivalent to Rv3157,len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 553 aa overlap). Probable nuoM,integral membrane NADH dehydrogenase I, chain M (EC 1.6.5.3), similar to others e.g. Q9XAR6|NUOM from Streptomyces coelicolor (523 aa), FASTA scores: opt: 1621,E(): 4.2e-89, (56.55% identity in 541 aa overlap); P50974|NUOM_RHOCA|NUOM from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (512 aa), FASTA scores: opt: 996, E(): 6.5e-52, (38.2% identity in 521 aa overlap); P29925|NQOD_PARDE|NQO13 from Paracoccus denitrificans (513 aa), FASTA scores: opt: 987, E(): 2.2e-51, (37.05% identity in 540 aa overlap); etc. Also similar to MTCY251.04 (FASTA score: E(): 3.3e-16) and MTCY03A2.02c (FASTA score: E(): 9.6e-13). SIMILAR TO POLYPEPTIDE 4 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIAL.	Q7TX54	No	intermediary metabolism and respiration							IPR001750,IPR003918,IPR010227	Q7TX54	A0A1R3Y3M4				Rv3157		Rv3157			
NC_002945.3	Mycobrowser_v4	CDS	3480899	3482494	.	+	0	Mb3182	nuoN		PROBABLE NADH DEHYDROGENASE I (CHAIN N) NUON (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN N)	Mb3182, nuoN, len: 531 aa. Equivalent to Rv3158,len: 531 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 531 aa overlap). Probable nuoN,integral membrane NADH dehydrogenase I, chain N (EC 1.6.5.3), similar to others e.g. Q9XAR7|SC10A7.08c from Streptomyces coelicolor (552 aa), FASTA scores: opt: 1493,E(): 1.1e-81, (56.7% identity in 543 aa overlap); Q9PGI2|XF0318 from Xylella fastidiosa (485 aa), FASTA scores: opt: 942, E(): 7.4e-49, (39.6% identity in 379 aa overlap); CAB51628|NUON2 from Rhizobium meliloti (Sinorhizobium meliloti) (479 aa), FASTA scores: opt: 934,E(): 2.2e-48, (35.5% identity in 479 aa overlap); etc. But also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES CHAIN 4L (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) e.g. P29801|NU2C_SYNP7|NDHB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (521 aa), FASTA scores: opt: 921, E(): 1.4e-47, (40.25% identity in 395 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 2 FAMILY.	X2BMS3,P0A5M1	No	intermediary metabolism and respiration								X2BMS3,P0A5M1	P0A5M1				Rv3158		Rv3158			
NC_002945.3	Mycobrowser_v4	CDS	3482500	3484269	.	-	0	Mb3183c	PPE53		ppe family protein ppe53	Mb3183c, PPE53, len: 589 aa. Equivalent to Rv3159c,len: 590 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 590 aa overlap). Member of the Mycobacterium tuberculosis PPE_family of Gly-, Asn-rich proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 2289, E(): 3.2e-98, (63.5% identity in 600 aa overlap); and also similar to MTCY48_17, MTV041_29, MTCY6G11_5, MTCY98_24, etc. TBparse score is 0.921. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, albeit a 2143 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TX53	No								IPR000030,IPR002989	Q7TX53	A0A1R3Y3B2									
NC_002945.3	Mycobrowser_v4	CDS	3484517	3486415	.	-	0	Mb3184c	PPE70		PPE FAMILY PROTEIN	Mb3184c, PPE70, len: 685 aa. Equivalent to MT3248,len: 686 aa, from Mycobacterium tuberculosis strain CDC1551, (99.708% identity in 686 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an insertion of 2143 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to a additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551.	Q7TX52	No								IPR000030,IPR002989	Q7TX52	A0A1R3Y3A8									
NC_002945.3	Mycobrowser_v4	CDS	3490194	3491156	.	-	0	Mb3189c	moxR3		PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN MOXR3	Mb3189c, moxR3, len: 320 aa. Equivalent to Rv3164c,len: 320 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 320 aa overlap). Probable moxR3,methanol dehydrogenase regulatory protein, highly similar to Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa), FASTA scores: opt: 1227,E(): 1.7e-67, (60.25% identity in 302 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 1126, E(): 2.3e-61, (54.1% identity in 305 aa overlap); Q9HSH7|MOXR|VNG0223G METHANOL DEHYDROGENASE REGULATORY PROTEIN from Halobacterium sp. strain NRC-1 (318 aa), FASTA scores: opt: 1072, E(): 4.5e-58, (51.45% identity in 315 aa overlap); Q9RVV4|DR0918 MOXR-RELATED PROTEIN from Deinococcus radiodurans (354 aa), FASTA scores: opt: 1000, E(): 1.2e-53, (50.95% identity in 318 aa overlap); etc. Also high similarity with several hypothetical bacterial proteins.	Q7TX47	No								IPR011703,IPR016366,IPR027417	Q7TX47	A0A1R3Y3Z2									
NC_002945.3	Mycobrowser_v4	CDS	3495756	3497102	.	+	0	Mb3195	aofH		PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE OXIDASE) (MAO)	Mb3195, aofH, len: 448 aa. Equivalent to Rv3170,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Probable aofH,flavin-containing (mono)amine oxidase (EC 1.4.3.4),similar to many eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) (522 aa), FASTA scores: opt: 869, E(): 5.3e-44, (37.7% identity in 448 aa overlap); P21396|AOFA_RAT|MAOA from Rattus norvegicus (Rat) (526 aa), FASTA scores: opt: 839, E(): 3.2e-42, (37.45% identity in 446 aa overlap); Q99NA8|MAO-A from Cavia porcellus (Guinea pig) (506 aa), FASTA scores: opt: 836,E(): 4.6e-42, (37.0% identity in 446 aa overlap); P21398|AOFA_BOVIN from Bos taurus (Bovine) (527 aa), FASTA scores: opt: 806, E(): 2.8e-40, (37.0% identity in 446 aa overlap); P21397|AOFA_HUMAN (527 aa), FASTA scores: opt: 801, E(): 5.6e-40, (37.2% identity in 446 aa overlap); etc. Alternative start possible at position 3538487. BELONGS TO THE FLAVIN MONOAMINE OXIDASE FAMILY. COFACTOR: FAD (POTENTIAL).	X2BNL4,P63534	No	intermediary metabolism and respiration								X2BNL4,P63534	P63534				Rv3170		Rv3170			
NC_002945.3	Mycobrowser_v4	tRNA	3513905	3513978	.	-	0	metU	metU		tRNA-Met	metU, len: 74 nt. Equivalent to metU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-f-Met, anticodon cat. Described in EM_BA: MTMETA Y08623 M.tuberculosis as metA gene. Name changed to metU as metA encodes homoserine transsuccinylase.; fMet		No																			
NC_002945.3	Mycobrowser_v4	CDS	3497097	3497996	.	-	0	Mb3196c	hpx		POSSIBLE NON-HEME HALOPEROXIDASE HPX	Mb3196c, hpx, len: 299 aa. Equivalent to Rv3171c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 299 aa overlap). Possible hpx, non-heme haloperoxidase (EC 1.11.1.-), similar to other hydrolases (principaly epoxide hydrolases) and non-heme chloroperoxidases e.g. Q9RKB6|SCE87.22c PUTATIVE HYDROLASE from Streptomyces coelicolor (314 aa), FASTA scores: opt: 431, E(): 6e-20, (38.05% identity in 297 aa overlap); Q9HZ14|PA3226 PROBABLE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas aeruginosa (275 aa),FASTA scores: opt: 236, E(): 1e-07, (29.6% identity in 277 aa overlap); Q9DBL9|1300003 D03RIK PROTEIN SIMILAR TO ALPHA/BETA HYDROLASE FOLD from Mus musculus (Mouse) (351 aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35% identity in 304 aa overlap); AAK46260|MT1988 EPOXIDE HYDROLASE from Mycobacterium tuberculosis strain CDC1551 (356 aa), FASTA scores: opt: 223, E(): 8.4e-07, (40.7% identity in 113 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) from Streptomyces lividans (275 aa), FASTA scores: opt: 220, E(): 1e-06, (29.5% identity in 305 aa overlap); etc. Equivalent to AAK47599 Hydrolase,alpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 but shorter 24 aa. Start chosen by similarity, alternative with good RBS possible.	Q7TX41	No									Q7TX41	A0A1R3Y3B7									
NC_002945.3	Mycobrowser_v4	CDS	3620882	3622684	.	+	0	Mb3313	accA3		PROBABLE BIFUNCTIONAL PROTEIN ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE (ALPHA CHAIN) ACCA3: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)	Mb3313, accA3, len: 600 aa. Equivalent to Rv3285,len: 600 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 600 aa overlap). Probable accA3,bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (EC 6.3.4.14) (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN from Mycobacterium leprae (598 aa), FASTA scores: opt: 3510,E(): 1.1e-196, (89.3% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC ACYL COENZYME A CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776,E(): 5.6e-154, (71.95% identity in 592 aa overlap); Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa), FASTA scores: opt: 2723, E(): 6.7e-151, (70.5% identity in 590 aa overlap); Q54105|BCPA BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (597 aa), FASTA scores: opt: 2721, E(): 8.9e-151, (70.05% identity in 594 aa overlap); Q9EWV4|2SCK31.20 PUTATIVE ACYL-COA CARBOXYLASE COMPLEX A SUBUNIT from Streptomyces coelicolor (590 aa), FASTA scores: opt: 2626, E(): 2.9e-145, (68.25% identity in 595 aa overlap); etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2, PS00188 Biotin-requiring enzymes attachment site. SIMILAR TO OTHER BIOTIN-DEPENDENT ENZYMES AND CARBAMOYL-PHOSPHATE SYNTHETASES.	Q7TWT5	No								IPR000089,IPR001882,IPR005479,IPR005481,IPR005482,IPR011053,IPR011054,IPR011761,IPR011764,IPR013815,IPR013816,IPR016185	Q7TWT5	A0A1R3Y3P4									
NC_002945.3	Mycobrowser_v4	CDS	3501595	3501912	.	-	0	Mb3201c	mesTb		PROBABLE EPOXIDE HYDROLASE MESTB [SECOND PART] (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)	Mb3201c, mesTb, len: 105 aa. Equivalent to 3' end of Rv3176c, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 105 aa overlap). Probable mesT,epoxide hydrolase (EC3.3.2.3), similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa),FASTA scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, E(): 3e-09, (29.85% identity in 288 aa overlap); O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in 278 aa overlap); etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA PROTEIN from Mycobacterium tuberculosis (288 aa),FASTA scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO PEPTIDASE FAMILY S33. Note that previously known as lipS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb.	Q7TX36	No									Q7TX36	A0A1R3Y3P5									
NC_002945.3	Mycobrowser_v4	CDS	3501924	3502550	.	-	0	Mb3202c	mesTa		PROBABLE EPOXIDE HYDROLASE MESTA [FIRST PART] (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)	Mb3202c, mesTa, len: 208 aa. Equivalent to 5' end of Rv3176c, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 201 aa overlap). Probable mesT, epoxide hydrolase (EC 3.3.2.3), similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa),FASTA scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, E(): 3e-09, (29.85% identity in 288 aa overlap); O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in 278 aa overlap); etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA PROTEIN from Mycobacterium tuberculosis (288 aa),FASTA scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO PEPTIDASE FAMILY S33. Note that previously known as lipS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb.	Q7TX35	No									Q7TX35	A0A1R3Y3B3									
NC_002945.3	Mycobrowser_v4	CDS	3521231	3521431	.	-	0	Mb3219c	Mb3219c		unknown protein	Mb3219c, -, len: 66 aa. Equivalent to Rv3196A, len: 66 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 66 aa overlap). Hypothetical unknown protein.	Q7TX18,A0A1R3Y3L2	No	conserved hypotheticals			A0A1R3Y3L2					Q7TX18					Rv3196A		Rv3196A			
NC_002945.3	Mycobrowser_v4	CDS	3626370	3626822	.	-	0	Mb3319c	lrpa		probable transcriptional regulatory protein lrpa (lrp/asnc-family)	Mb3319c, -, len: 150 aa. Equivalent to Rv3291c,len: 150 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 150 aa overlap). Probable transcriptional regulator asnC-family, similar to other regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces coelicolor (165 aa), FASTA scores: opt: 503, E(): 9.1e-26,(50.35% identity in 143 aa overlap); Q9KYP0|SCD69.13 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 310,E(): 2.7e-13, (37.2% identity in 129 aa overlap); BAB50701|MLL3910 from Rhizobium loti (Mesorhizobium loti) (152 aa), FASTA scores: opt: 282, E(): 1.6e-11, (39.55% identity in 129 aa overlap); O87635|LRP_KLEAE from Klebsiella aerogenes (163 aa), FASTA scores: opt: 279,E(): 2.5e-11, (38.1% identity in 147 aa overlap); etc. Contains helix-turn-helix motif at aa 22-43 (+3.94 SD). COULD BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TWT2	No	regulatory proteins							IPR000485,IPR011008,IPR011991,IPR019887,IPR019888	Q7TWT2	A0A1R3Y3Z0				Rv3291c		Rv3291c			
NC_002945.3	Mycobrowser_v4	CDS	3522946	3523224	.	-	0	Mb3221c	whiB7		PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB7	Mb3221c, whiB7, len: 92 aa. Equivalent to Rv3197A,len: 92 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 92 aa overlap). Probable whiB7,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL REGULATOR WHIB7 from Mycobacterium leprae (89 aa), FASTA scores: opt: 441, E(): 6.3e-24, (69.3% identity in 88 aa overlap). Similar to Q9FCJ8|2SC3B6.14 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (122 aa), FASTA scores: opt: 348, E(): 2.2e-17, (57.7% identity in 78 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa), FASTA scores: opt: 166,E(): 7.1e-05, (39.4% identity in 76 aa overlap); etc.	Q7TX16	No								IPR003482,IPR017956	Q7TX16	A0A1R3Y3E1									
NC_002945.3	Mycobrowser_v4	CDS	3523654	3525756	.	-	0	Mb3222c	uvrD2		probable atp-dependent dna helicase ii uvrd2	Mb3222c, UvrD2, len: 700 aa. Equivalent to Rv3198c,len: 700 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 700 aa overlap). Probable UvrD2, DNA helicase II homolog (EC 3.6.1.-), equivalent to P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 PROBABLE DNA HELICASE II HOMOLOG from Mycobacterium leprae (714 aa), FASTA scores: opt: 3749, E(): 0, (82.85% identity in 706 aa overlap); and C-terminal half (466-700 aa) corresponds to Q49764|RECQ|B1937_F2_66 PUTATIVE DNA HELICASE RECQ (EC 3.6.1.-) (242 aa), FASTA scores: opt: 1267, E(): 1.4e-69, (82.5% identity in 234 aa overlap); products of two adjacent ORFS in Mycobacterium leprae. Also similar to other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces coelicolor (785 aa), FASTA scores: opt: 1687, E(): 1.2e-94, (52.05% identity in 728 aa overlap); P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in 710 aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium leprae (778 aa), FASTA scores: opt: 687, E(): 5.1e-34, (32.0% identity in 719 aa overlap); O83991|TP1028 DNA HELICASE II (UVRD) from Treponema pallidum (670 aa), FASTA scores: opt: 652, E(): 6e-32, (30.25% identity in 671 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES.	X2BMV8,P64321	No									X2BMV8,P64321	P64321									
NC_002945.3	Mycobrowser_v4	CDS	3526147	3527088	.	-	0	Mb3224c	nudC		PROBABLE NADH PYROPHOSPHATASE NUDC (NAD+ DIPHOSPHATASE) (NAD+ PYROPHOSPHATASE) (NADP PYROPHOSPHATASE)	Mb3224c, nudC, len: 313 aa. Equivalent to Rv3199c,len: 313 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 313 aa overlap). Probable nudC, NADH pyrophosphatase (EC 3.6.1.22), similar in particular to Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa),FASTA scores: opt: 493, E(): 7.4e-24, (39.65% identity in 232 aa overlap); Q9ABG1|CC0266 MUTT/NUDIX FAMILY PROTEIN from Caulobacter crescentus (313 aa), FASTA scores: opt: 479, E(): 5.1e-23, (38.3% identity in 222 aa overlap); O86062|NUDC_PSEAE|NUDC|PA1823 NADH PYROPHOSPHATASE from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 371,2 E(): 3e-16, (43.15% identity in 153 aa overlap); Q9RV62|NUDC_DEIRA|NUDC|DR1168 NADH PYROPHOSPHATASE from Deinococcus radiodurans (280 aa), FASTA scores: opt: 363,E(): 9.6e-16, (34.45% identity in 270 aa overlap); etc. Caution: equivalent to AAK47636 from Mycobacterium tuberculosis strain CDC1551 (386 aa) but shorter 72 aa. Contains PS00893 mutT domain signature. BELONGS TO THE NUDIX HYDROLASE FAMILY, NUDC SUBFAMILY. COFACTOR: REQUIRES DIVALENT IONS: MANGANESE OR MAGNESIUM.	X2BNP2,Q7TX14	No									X2BNP2,Q7TX14	Q7TX14									
NC_002945.3	Mycobrowser_v4	CDS	3535071	3535856	.	+	0	Mb3228	lipV		POSSIBLE LIPASE LIPV	Mb3228, lipV, len: 261 aa. Equivalent to alpha/beta hydrolase from Mycobacterium tuberculosis strain CDC1551 (100% identity with 260 aa overlap). Similar to Rv3203,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(86.0% identity in 224 aa overlap). Possible lipV,hydrolase lipase (EC 3.1.-.-), showing some similarity to other lipases e.g. Q9JSN0|NMA2216 PUTATIVE HYDROLASE from Neisseria meningitidis (serogroup A) (312 aa),Q9RK95|SCF1.09 PUTATIVE HYDROLASE from Streptomyces coelicolor (258 aa), Q9KZC3|SC6F7.19c PUTATIVE LIPASE from Streptomyces coelicolor (269 aa), etc. Contains serine active site signature of lipases (PS00120). Mb3228 transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BNB5	No									X2BNB5	A0A1R3Y3L7									
NC_002945.3	Mycobrowser_v4	CDS	3542339	3543922	.	+	0	Mb3237	rhlE		PROBABLE ATP-DEPENDENT RNA HELICASE RHLE	Mb3237, rhlE, len: 527 aa. Equivalent to Rv3211,len: 527 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 527 aa overlap). Probable rhlE,ATP-dependent RNA helicase, equivalent (but shorter 22 aa) to Q9CCH3|RHLE|ML0811 PUTATIVE ATP-DEPENDENT RNA HELICASE from Mycobacterium leprae (544 aa), FASTA scores: opt: 2497, E(): 8.7e-131, (74.75% identity in 531 aa overlap). Also highly similar to other RNA helicases e.g. Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879 aa),FASTA scores: opt: 1458, E(): 3.6e-73, (52.5% identity in 522 aa overlap); Q9DF36 from Xenopus laevis (African clawed frog) (800 aa), FASTA scores: opt: 792, E(): 2.3e-36, (37.15% identity in 385 aa overlap); Q99Z38|DEAD|SPY1415 from Streptococcus pyogenes (759 aa),FASTA scores: opt: 779, E(): 1.1e-35, (37.1% identity in 380 aa overlap); P33906|DEAD|CSDA from Klebsiella pneumoniae (642 aa), FASTA scores: opt: 768, E(): 4e-35,(43.4% identity in 387 aa overlap); etc. Contains ATP/GTP-binding site motif A (PS00017) and DEAD-box subfamily ATP-dependent helicases signature (PS00039). SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND SIMILAR TO HELICASE C-TERMINAL DOMAIN.	Q7TX01	No	information pathways							IPR000629,IPR001650,IPR011545,IPR014001,IPR014014,IPR027417	Q7TX01	A0A1R3Y436				Rv3211		Rv3211			
NC_002945.3	Mycobrowser_v4	CDS	3537076	3538251	.	-	0	Mb3231c	moeB1		PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE)	Mb3231c, moeB1, len: 391 aa. Equivalent to Rv3206c,len: 392 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 392 aa overlap). Probable moeB1,molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 2285, E(): 3.3e-130, (86.45% identity in 391 aa overlap.) Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1776, E(): 1.4e-99, (65.3% identity in 395 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1526, E(): 1.5e-84, (59.1% identity in 391 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1309, E(): 1.8e-71, (52.95% identity in 387 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1308,E(): 2e-71, (50.65% identity in 397 aa overlap); etc. Also highly similar to O05792|MOEB2|Rv3116|MTCY164.26 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (389 aa), FASTA scores: opt: 1440, E(): 2.3e-79, (57.25% identity in 386 aa overlap). Has hydrophobic segment from ~45-71. BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeZ.	Q7TX07	No								IPR000594,IPR001763,IPR007901,IPR009036,IPR016040	Q7TX07	A0A1R3Y3H4									
NC_002945.3	Mycobrowser_v4	CDS	3540218	3540490	.	-	0	Mb3234c	TB9.4		conserved protein tb9.4	Mb3234c, TB9.4, len: 90 aa. Equivalent to Rv3208A,len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 90 aa overlap). TB9.4, conserved hypothetical protein (see citations below), equivalent to Q9CCH1|ML0814 HYPOTHETICAL PROTEIN from Mycobacterium leprae (82 aa), FASTA scores: opt: 411, E(): 1.8e-22,(81.0% identity in 79 aa overlap). Also similar, but shorter in N-terminus, to Q9FBI9|SCP8.32c PUTATIVE ATP-BINDING PROTEIN from Streptomyces coelicolor (94 aa),FASTA scores: opt: 246, E(): 8.1e-11, (53.4% identity in 73 aa overlap); Q9DGP6 (alias Q9DGP4) GLUTAMATE DECARBOXYLASE 67 KDA ISOFORM (FRAGMENT) from Alepocephalus bairdii (182 aa), FASTA scores: opt: 100, E(): 2.6, (35.3% identity in 85 aa overlap). Corresponds to Statens Serum Institute antigen, CYP10 TB9.4. Has N-terminal sequence,VEVKIGITDSPRELV.	Q7TX04	No								IPR021456	Q7TX04	A0A1R3Y3G0									
NC_002945.3	Mycobrowser_v4	CDS	3546189	3546800	.	+	0	Mb3240	gpm2		POSSIBLE PHOSPHOGLYCERATE MUTASE GPM2 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	Mb3240, gpm2, len: 203 aa. Equivalent to Rv3214,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Possible gpm2,phosphoglycerate mutase (EC 5.4.2.1), similar to many mutases especially phosphoglycerate mutases e.g. Q9F3H5|2SCC13.14c PUTATIVE MUTASE from Streptomyces coelicolor (198 aa), FASTA scores: opt: 487, E(): 4.4e-25,(42.25% identity in 194 aa overlap); BAB49378|MLL2186 PROBABLE PHOSPHOGLYCERATE MUTASE from Rhizobium loti (Mesorhizobium loti) (193 aa), FASTA scores: opt: 423,E(): 7e-21, (41.2% identity in 182 aa overlap); Q9RKV8|SC9G1.08c PUTATIVE PHOSPHATASE from Streptomyces coelicolor (199 aa), FASTA scores: opt: 419, E(): 1.3e-20,(41.1% identity in 185 aa overlap); Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 240, E(): 8.8e-09,(36.9% identity in 168 aa overlap); Q9X194|TM1374 PHOSPHOGLYCERATE MUTASE from Thermotoga maritima (201 aa),FASTA scores: opt: 218, E(): 2.3e-07, (33.15% identity in 202 aa overlap); etc. But N-terminus also similar to Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa), FASTA scores: opt: 346,E(): 2.1e-15, (55.05% identity in 109 aa overlap). N-terminus shows also some similarity with other M. tuberculosis proteins e.g. MTCY427.09c; MTCY20G9.15; MTCY428.28. Equivalent to AAK47652 from Mycobacterium tuberculosis strain CDC1551 (228 aa) but shorter 25 aa. Note that previously known as entD.	Q7TWZ8	No	intermediary metabolism and respiration							IPR013078	Q7TWZ8	A0A1R3Y3F8				Rv3214		Rv3214			
NC_002945.3	Mycobrowser_v4	CDS	3582019	3582663	.	-	0	Mb3275c	tmk		thymidylate kinase tmk (dtmp kinase) (thymidylic acid kinase) (tmpk)	Mb3275c, tmk, len: 214 aa. Equivalent to Rv3247c,len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 214 aa overlap). Probable tmk,thymidylate kinase (EC 2.7.4.9), equivalent to Q9CCJ3|TMK|ML0772 PUTATIVE THYMIDYLATE KINASE from Mycobacterium leprae (210 aa), FASTA scores: opt: 1023,E(): 4.8e-57, (77.3% identity in 207 aa overlap). Also similar to other thymidylate kinases e.g. Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from Caulobacter crescentus (208 aa), FASTA scores: opt: 179, E(): 0.0003, (31.3% identity in 214 aa overlap); Q9V1E9|KTHY_PYRAB|TMK|PAB0319 from Pyrococcus abyssi (205 aa), FASTA scores: opt: 176,E(): 0.00045, (29.1% identity in 189 aa overlap); etc. BELONGS TO THE THYMIDYLATE KINASE FAMILY.	Q7TWW8	No								IPR018094,IPR018095,IPR027417	Q7TWW8	A0A1R3Y3J9									
NC_002945.3	Mycobrowser_v4	CDS	3546797	3547915	.	+	0	Mb3241	entC		PROBABLE ISOCHORISMATE SYNTHASE ENTC (ISOCHORISMATE HYDROXYMUTASE) (ENTEROCHELIN BIOSYNTHESIS)	Mb3241, entC, len: 372 aa. Equivalent to Rv3215,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 372 aa overlap). Probable entC,isochorismate synthase (EC 5.4.99.6), equivalent to Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa), FASTA scores: opt: 1817,E(): 5.5e-105, (73.5% identity in 366 aa overlap). Also similar to others e.g. Q9F639|MXCD PROTEIN INVOLVED IN MYXOCHELIN-TYPE IRON CHELATOR BIOSYNTHESIS (see citation below) from Stigmatella aurantiaca (408 aa), FASTA scores: opt: 893, E(): 6.2e-48, (41.6% identity in 382 aa overlap); P45744|DHBC_BACSU ISOCHORISMATE SYNTHASE from Bacillus subtilis (398 aa), FASTA scores: opt: 883, E(): 2.5e-47, (40.45% identity in 393 aa overlap); Q9KI93|CSBC ISOCHORISMATE SYNTHASE (FRAGMENT) from Azotobacter vinelandii (361 aa), FASTA scores: opt: 794, E(): 7.6e-42,(45.65% identity in 298 aa overlap); and the two Escherichia coli proteins AAG54928|ENTC (alias BAB34055|ECS0632) ISOCHORISMATE HYDROXYMUTASE 2 from Escherichia coli strain O157:H7 (391 aa), FASTA scores: opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap); P10377|ENTC|B0593 ISOCHORISMATE SYNTHASE from Escherichia coli strain K12 (391 aa), FASTA scores: opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap); etc. Stronger similarity to Escherichia coli entC. Also similar to MTCY253.35.	Q7TWZ7	No	intermediary metabolism and respiration							IPR004561,IPR005801,IPR015890	Q7TWZ7	A0A1R3Y3I2				Rv3215		Rv3215			
NC_002945.3	Mycobrowser_v4	CDS	3550312	3550566	.	+	0	Mb3245	whiB1		transcriptional regulatory protein whib-like whib1. contains [4fe-4s]2+ cluster.	Mb3245, whiB1, len: 84 aa. Equivalent to Rv3219,len: 84 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 84 aa overlap). Probable whiB1,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor. Equivalent to Q9CCH7|WHIB1|ML0804 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (84 aa), FASTA scores: opt: 580,E(): 3.5e-35, (95.25% identity in 84 aa overlap). Highly similar to several e.g. Q9X952|WBLE DEVELOPMENTAL REGULATORY PROTEIN WHIB-PARALOG from Streptomyces coelicolor (85 aa), FASTA scores: opt: 477, E(): 9.2e-28,(75.3% identity in 81 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa),FASTA scores: opt: 383, E(): 6.1e-21, (60.75% identity in 79 aa overlap); Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83 aa), FASTA scores: opt: 346, E(): 2.5e-18,(54.75% identity in 84 aa overlap); etc.	Q7TWZ3	No	regulatory proteins							IPR003482	Q7TWZ3	A0A1R3Y3G7				Rv3219		Rv3219			
NC_002945.3	Mycobrowser_v4	CDS	3552150	3552365	.	-	0	Mb3247c	TB7.3		BIOTINYLATED PROTEIN TB7.3	Mb3247c, TB7.3, len: 71 aa. Equivalent to Rv3221c,len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 71 aa overlap). Biotinylated protein TB7.3 (see citation below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium leprae (70 aa), FASTA scores: opt: 367, E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341, E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G BIOTIN CARBOXYLASE from Halobacterium sp. strain NRC-1 (610 aa),FASTA scores: opt: 212, E(): 4e-07, (50.0% identity in 68 aa overlap); Q58628|PYCB_METJA|MJ1231 PYRUVATE CARBOXYLASE SUBUNIT B from Methanococcus jannaschii (567 aa), FASTA scores: opt: 192, E(): 7.8e-06, (44.8% identity in 58 aa overlap); Q9ZAA7|GCDC GLUTACONYL-COA DECARBOXYLASE GAMMA SUBUNIT from Acidaminococcus fermentans (145 aa), FASTA scores: opt: 184, E(): 8.9e-06, (39.4% identity in 66 aa overlap); etc.	X2BMX3	No									X2BMX3	P0A511									
NC_002945.3	Mycobrowser_v4	CDS	3552650	3552955	.	-	0	Mb3248c	rsha		anti-sigma factor rsha	Mb3248c, -, len: 101 aa. Equivalent to Rv3221A,len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Possible anti-sigma factor, similar to Q9XCD7|AAD41811.1 unknown protein from Mycobacterium smegmatis, linked to sigma factor sigH (see first citation below) (101 aa), FASTA scores: opt: 422,E(): 3.4e-22, (64.9% identity in 94 aa overlap); and to Q9RL96|RsrA anti-sigma factor from Streptomyces coelicolor (see second citation) (105 aa), FASTA scores: opt: 163,E(): 0.00016, (32.05% identity in 78 aa overlap).	Q7TWZ1	No	information pathways							IPR014295,IPR024020,IPR027383	Q7TWZ1	A0A1R3Y3M6				Rv3221A		Rv3221A			
NC_002945.3	Mycobrowser_v4	CDS	3553500	3554150	.	-	0	Mb3250c	sigH		ALTERNATIVE RNA POLYMERASE SIGMA-E FACTOR (SIGMA-24) SIGH (RPOE)	Mb3250c, sigH, len: 216 aa. Equivalent to Rv3223c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). sigH (alternate gene name: rpoE), alternative RNA polymerase sigma factor (see citations below), similar to many e.g. Q9XCD8|SIGH from Mycobacterium smegmatis (215 aa), FASTA scores: opt: 1187,E(): 8.1e-69, (87.75% identity in 212 aa overlap); O87834|SIGR from Streptomyces coelicolor (227 aa), FASTA scores: opt: 913, E(): 2.6e-51, (68.8% identity in 202 aa overlap); O68520|RPOE1 from Myxococcus xanthus (213 aa),FASTA scores: opt: 452, E(): 6.7e-22, (42.8% identity in 187 aa overlap); Q06198|RPSH_PSEAE|ALGU|ALGT|PA0762 from Pseudomonas aeruginosa (193 aa), FASTA scores: opt: 301,E(): 2.7e-12, (29.9% identity in 194 aa overlap); etc. Equivalent to AAK47662 RNA polymerase sigma-70 factor from Mycobacterium tuberculosis strain CDC1551 (284 aa), but shorter 68 aa. Has sigma-70 factors ECF subfamily signature (PS01063). So BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Start chosen on basis of similarity, other potential starts upstream.	X2BMK2,P66808	No									X2BMK2,P66808	P66808									
NC_002945.3	Mycobrowser_v4	CDS	3563469	3564356	.	-	0	Mb3261c	ppk2		polyphosphate kinase ppk2 (polyphosphoric acid kinase)	Mb3261c, pvdS, len: 295 aa. Equivalent to Rv3232c,len: 295 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 295 aa overlap). Possible pvdS, an alternative RNA polymerase sigma factor, highly similar (but N-terminus longer 25-50 residues approximatively) to Q9RIZ9|SCJ1.15 PUTATIVE REGULATOR from Streptomyces coelicolor (267 aa), FASTA scores: opt: 1189, E(): 1.4e-70, (65.65% identity in 262 aa overlap); Q9KU02|VC0728 HYPOTHETICAL PROTEIN from Vibrio cholerae (258 aa), FASTA scores: opt: 1074, E(): 4.5e-63, (62.6% identity in 254 aa overlap); P72119|PVDS PAO SUBSTRAIN OT684 PYOVERDINE GENE TRANSCRIPTIONAL REGULATOR PVDS (FRAGMENT) from Pseudomonas aeruginosa (see citation below) (237 aa), FASTA scores: opt: 988, E(): 1.8e-57,(60.8% identity in 227 aa overlap). Also highly similar to Q9I154|PA2428 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (304 aa), FASTA scores: opt: 1057, E(): 6.8e-62, (60.7% identity in 252 aa overlap); Q9I6Z1|PA0141 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (298 aa),FASTA scores: opt: 990, E(): 1.6e-57, (54.6% identity in 249 aa overlap); and other hypothetical bacterial proteins. Could be a member of a subfamily of RNA polymerase sigma factors which direct the synthesis of extracellular products by bacteria. Start uncertain.	Q7TWX9	No								IPR016898,IPR022486,IPR022488,IPR027417	Q7TWX9	A0A1R3Y3K6									
NC_002945.3	Mycobrowser_v4	CDS	3557976	3559328	.	+	0	Mb3256	aroA		3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE AROA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS)	Mb3256, aroA, len: 450 aa. Equivalent to Rv3227,len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 450 aa overlap). aroA,3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19) (see citation below), equivalent (but C-terminus longer) to Q9CCI3|AROA|ML0792 PUTATIVE 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYL TRANSFERASE from Mycobacterium leprae (430 aa), FASTA scores: opt: 1466, E(): 1.4e-78, (55.05% identity in 427 aa overlap). Contains PS00885 EPSP synthase signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY.	X2BMZ8,Q7TWY4	No	intermediary metabolism and respiration								X2BMZ8,Q7TWY4	Q7TWY4				Rv3227		Rv3227			
NC_002945.3	Mycobrowser_v4	CDS	3560350	3561633	.	-	0	Mb3258c	desa3		POSSIBLE LINOLEOYL-COA DESATURASE (DELTA(6)-DESATURASE)	Mb3258c, -, len: 427 aa. Equivalent to Rv3229c,len: 427 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 427 aa overlap). Possible linoleoyl-CoA desaturase (EC 1.14.19.3), showing similarity with desaturases and other proteins e.g. Q08871|DES6|SLL0262 LINOLEOYL-COA DESATURASE from Synechocystis sp. strain PCC 6803 (359 aa), FASTA scores: opt: 319, E(): 4e-13, (25.1% identity in 295 aa overlap); Q54795|DESD DELTA 6 DESATURASE from Spirulina platensis (368 aa), FASTA scores: opt: 268, E(): 7.7e-10, (25.0% identity in 300 aa overlap); Q9ZTU8|S276 PROTEIN WITH SIMILARITY TO CYTOCHROME B5 DOMAIN from Triticum aestivum (Wheat) (469 aa), FASTA scores: opt: 240, E(): 5.9e-08,(27.05% identity in 266 aa overlap); etc. Note that previously known as desA3.	Q7TWY2	No	lipid metabolism							IPR005804	Q7TWY2	A0A1R3Y3P3				Rv3229c		Rv3229c			
NC_002945.3	Mycobrowser_v4	CDS	3564380	3565789	.	-	0	Mb3262c	tgs3		possible triacylglycerol synthase (diacylglycerol acyltransferase)	Mb3262c, -, len: 469 aa. Equivalent to Rv3234c and Rv3233c, len: 271 aa and 196 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 266 aa overlap and 100.0% identity in 196 aa overlap). Rv3234c: Hypothetical protein, similar to C-terminus of Mycobacterium tuberculosis hypothetical proteins e.g. P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26; MTV013_8; MTY13E12_33; etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 309,E(): 4.3e-12, (33.35% identity in 189 aa overlap). Rv3233c: Hypothetical protein, similar to C-terminus of Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 308,E(): 1.2e-12, (32.0% identity in 200 aa overlap); and several hypothetical Mycobacterium tuberculosis proteins e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa),FASTA scores: opt: 248, E(): 9.8e-09, (27.5% identity in 200 aa overlap); MTCY28_26; MTCY493_29; MTCY31_25; MTCY31_25. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-g) leads to a single product that is more similar to Rv3234c.	Q7TWX8	No	lipid metabolism							IPR004255,IPR014292	Q7TWX8	A0A1R3Y3I4				Rv3234c		Rv3234c			
NC_002945.3	Mycobrowser_v4	CDS	3572282	3575131	.	-	0	Mb3268c	secA1		PROBABLE PREPROTEIN TRANSLOCASE SECA1 1 SUBUNIT	Mb3268c, secA1, len: 949 aa. Equivalent to Rv3240c,len: 949 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 949 aa overlap). Probable secA1,preprotein translocase subunit, component of secretion apparatus, highly similar to many e.g. P57996|SEA1_MYCLE from Mycobacterium leprae (940 aa), FASTA scores: opt: 5044, E(): 0, (87.5% identity in 849 aa overlap); P95759|SECA_STRGR from Streptomyces griseus (940 aa),FASTA scores: opt: 2612, E(): 1.9e-134, (61.35% identity in 960 aa overlap); P28366|SECA_BACSU|DIV+ from Bacillus subtilis (841 aa), FASTA scores: opt: 1776, E(): 4.9e-89,(48.05% identity in 837 aa overlap); etc. BELONGS TO THE SECA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA, SECD|Rv2587c, SECE|Rv0638,SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Note that previously known as secA.	X2BNE8,P0A5Y9	No									X2BNE8,P0A5Y9	P0A5Y9									
NC_002945.3	Mycobrowser_v4	CDS	3577759	3579510	.	-	0	Mb3272c	lpqB		PROBABLE CONSERVED LIPOPROTEIN LPQB	Mb3272c, lpqB, len: 583 aa. Equivalent to Rv3244c,len: 583 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 583 aa overlap). Probable lpqB,conserved lipoprotein; contains appropriately placed lipoprotein signature (PS00013). Equivalent to Q9CCJ0|LPQB|ML0775 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (589 aa), FASTA scores: opt: 3375, E(): 1.4e-186,(87.9% identity in 579 aa overlap). Also similar to various proteins (in particular transferases) e.g. Q9KYX0|SCE33.13c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (615 aa), FASTA scores: opt: 228, E(): 1.3e-05,(25.5% identity in 624 aa overlap); O87992|BBLPS1.19c PUTATIVE GLUTAMINE AMIDOTRANSFERASE from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (628 aa),FASTA scores: opt: 162, E(): 0.079, (28.05% identity in 171 aa overlap); Q9L2F4|SC7A8.01 PUTATIVE SUGAR KINASE (FRAGMENT) from Streptomyces coelicolor (434 aa), FASTA scores: opt: 143, E(): 0.72, (27.65% identity in 293 aa overlap); etc.	X2BMY9,Q7TWW9	No									X2BMY9,Q7TWW9	Q7TWW9									
NC_002945.3	Mycobrowser_v4	CDS	3579510	3581213	.	-	0	Mb3273c	mtrB		TWO COMPONENT SENSORY TRANSDUCTION HISTIDINE KINASE MTRB	Mb3273c, mtrB, len: 567 aa. Equivalent to Rv3245c,len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 567 aa overlap). mtrB, sensor-like histidine kinase (EC 2.7.3.-) (see citations below),equivalent to Q9CCJ1|MTRB OR ML0774 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (562 aa),FASTA scores: opt: 3208, E(): 7.4e-173, (88.7% identity in 566 aa overlap). Also similar to others e.g. Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (688 aa), FASTA scores: opt: 1355, E(): 1.1e-68, (48.95% identity in 515 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: MTCY369.03, E(): 1.5e-22; MTCY20G9.16, E(): 1.9e-17. SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES.	X2BNF3,P59963	No									X2BNF3,P59963	P59963									
NC_002945.3	Mycobrowser_v4	CDS	3581263	3581949	.	-	0	Mb3274c	mtrA		TWO COMPONENT SENSORY TRANSDUCTION TRANSCRIPTIONAL REGULATORY PROTEIN MTRA	Mb3274c, mtrA, len: 228 aa. Equivalent to Rv3246c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). mtrA, transcriptional activator, response regulator (see citations below),equivalent to Q9CCJ2|MTRA|ML0773 PUTATIVE TWO-COMPONENT RESPONSE REGULATOR from Mycobacterium leprae (228 aa),FASTA scores: opt: 1458, E(): 1.4e-85, (98.7% identity in 228 aa overlap). Also highly similar to others e.g. Q9F9J5|SCRA PUTATIVE RESPONSE REGULATOR from Streptomyces coelicolor (228 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9KYW8|SCE33.15c PUTATIVE TWO-COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (229 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9F868|REGX3 RESPONSE REGULATOR REGX3 from Mycobacterium smegmatis (228 aa), FASTA scores: opt: 730,E(): 2.3e-39, (50.90% identity in 222 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: U01971|MTU01971_1; Q11156|RGX3_MYCTU; MTCY20G9.17, E(): 0; MTCY31.31c, E(): 3.4e-29; MTCY369.02, E(): 5.7e-28. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages.	X2BNU1,P0A5Z5	No									X2BNU1,P0A5Z5	P0A5Z5									
NC_002945.3	Mycobrowser_v4	CDS	3582760	3584247	.	-	0	Mb3276c	sahH		PROBABLE ADENOSYLHOMOCYSTEINASE SAHH (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE)	Mb3276c, sahH, len: 495 aa. Equivalent to Rv3248c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Probable sahH,adenosylhomocysteinase (EC 3.3.1.1), equivalent to Q9CCJ4|SAHH|ML0771 PUTATIVE S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE from Mycobacterium leprae (492 aa), FASTA scores: opt: 3019, E(): 1.3e-177, (91.4% identity in 489 aa overlap). Also highly similar to other adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces coelicolor (485 aa), FASTA scores: opt: 2258, E(): 5.7e-131, (70.0% identity in 483 aa overlap); P51540|SAHH_TRIVA from Trichomonas vaginalis (486 aa),FASTA scores: opt: 2005, E(): 1.8e-115, (62.05% identity in 477 aa overlap); P35007|SAHH_CATRO from Catharanthus roseus (Rosy periwinkle) (Madagascar periwinkle) (485 aa),FASTA scores: opt: 1941, E(): 1.5e-111, (60.15% identity in 492 aa overlap); etc. Has S-adenosyl-L-homocysteine hydrolase signature (PS00739). BELONGS TO THE ADENOSYLHOMOCYSTEINASE FAMILY.	X2BN18,Q7TWW7	No									X2BN18,Q7TWW7	Q7TWW7									
NC_002945.3	Mycobrowser_v4	CDS	3600579	3601472	.	-	0	Mb3293c	wbbL1		dtdp-rha:a-d-glcnac-diphosphoryl polyprenol,a-3-l-rhamnosyl transferase wbbl1 (alpha-l-rhamnose-(1->3)-alpha-d-glcnac(1->p)-p-decaprenyl)	Mb3293c, wbbL1, len: 297 aa. Equivalent to Rv3265c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 301 aa overlap). Probable wbbL1,dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL TRANSFERASE (EC 2.-.-.-) (see citation below), equivalent to Q9CCK7|WBBL|ML0752 PUTATIVE DTDP-RHAMNOSYL TRANSFERASE from Mycobacterium leprae (308 aa), FASTA scores: opt: 1788, E(): 3e-104, (85.05% identity in 301 aa overlap); and Q9RN50|WBBL|Q9RN49 (see note * below) DTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL,A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium smegmatis (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86, (72.35% identity in 293 aa overlap). Note that previously known as wbbL. [* Note: UNPUBLISHED (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme,dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol,a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A., Motichka K., Jucker M., Wu H.P.,Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W.,Pan F., Kimbrel S., Kundu M., McNeil M.]. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301 aa).	Q7TTR5	No									Q7TTR5	A0A1R3Y3L3									
NC_002945.3	Mycobrowser_v4	CDS	3584984	3585166	.	-	0	Mb3278c	rubB		PROBABLE RUBREDOXIN RUBB	Mb3278c, -, len: 60 aa. Equivalent to Rv3250c, len: 60 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 60 aa overlap). Probable rubB,rubredoxin, highly similar to other rubredoxins e.g. Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA scores: opt: 391, E(): 2.2e-21, (83.05% identity in 59 aa overlap); Q9AE63|RUBA2 from Rhodococcus erythropolis (63 aa), FASTA scores: opt: 380, E(): 1.4e-20, (83.9% identity in 56 aa overlap); P42453|RUBR_ACICA|RUBA from Acinetobacter calcoaceticus (54 aa), FASTA scores: opt: 315, E(): 4.9e-16, (69.8% identity in 53 aa overlap); Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa), FASTA scores: opt: 298, E(): 8e-15, (64.15% identity in 53 aa overlap); Q9PGC3|XF0379 from Xylella fastidiosa (57 aa),FASTA scores: opt: 263, E(): 2.5e-12, (59.25% identity in 54 aa overlap); etc. Also similar to neighbouring ORF M. tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY.	Q7TWW5	No	intermediary metabolism and respiration							IPR004039,IPR018527,IPR024934,IPR024935	Q7TWW5	A0A1R3Y3R1				Rv3250c		Rv3250c			
NC_002945.3	Mycobrowser_v4	CDS	3585171	3585338	.	-	0	Mb3279c	rubA		PROBABLE RUBREDOXIN RUBA	Mb3279c, -, len: 55 aa. Equivalent to Rv3251c, len: 55 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 55 aa overlap). Probable rubA,rubredoxin, highly similar to other rubredoxins (but sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus erythropolis (61 aa), FASTA scores: opt: 335, E(): 1e-17,(73.6% identity in 53 aa overlap); P00272|RUB2_PSEOL|ALKG from Pseudomonas oleovorans (172 aa), FASTA scores: opt: 278, E(): 2.7e-13, (65.3% identity in 49 aa overlap); CAC38028|ALKG from Alcanivorax borkumensis (174 aa), FASTA scores: opt: 271, E(): 8.6e-13, (62.0% identity in 50 aa overlap); Q9WWW4|ALKG from Pseudomonas putida (175 aa),FASTA scores: opt: 270, E(): 1e-12, (61.8% identity in 55 aa overlap); etc. Also highly similar to C-terminus of Q9XBM1|ALKB ALKANE 1-MONOOXYGENASE (EC 1.14.15.3) from Prauserella rugosa (490 aa), FASTA scores: opt: 296, E(): 2.9e-14, (75.5% identity in 49 aa overlap). Also similar to neighbouring ORF Mycobacterium tuberculosis rubB (MTCY20B11.25c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY.	Q7TWW4	No	intermediary metabolism and respiration							IPR004039,IPR018527,IPR024934,IPR024935	Q7TWW4	A0A1R3Y3V9				Rv3251c		Rv3251c			
NC_002945.3	Mycobrowser_v4	CDS	3585338	3586588	.	-	0	Mb3280c	alkB		PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN)	Mb3280c, alkB, len: 416 aa. Equivalent to Rv3252c,len: 416 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 416 aa overlap). Probable alkB,transmembrane alkane-1-monooxygenase (EC 1.14.15.3),highly similar to many e.g. Q9AE68|ALKB2 from Rhodococcus erythropolis (408 aa), FASTA scores: opt: 2018, E(): 9.6e-122, (68.6% identity in 415 aa overlap); Q9AFD5|ALKB from Nocardioides sp. CF8 (483 aa), FASTA scores: opt: 1485, E(): 1.4e-87, (56.55% identity in 405 aa overlap); Q9XAU0|ALKB1 from Rhodococcus erythropolis (391 aa), FASTA scores: opt: 1400, E(): 3.3e-82, (62.6% identity in 396 aa overlap); Q9XBM1|ALKB from Prauserella rugosa (490 aa),FASTA scores: opt: 1266, E(): 1.5e-73, (57.55% identity in 410 aa overlap); CAC40954|ALKB4 from Rhodococcus erythropolis (386 aa), FASTA scores: opt: 1190, E(): 9.1e-69, (54.3% identity in 383 aa overlap); etc.	Q7TWW3	No								IPR005804	Q7TWW3	A0A1R3Y3K1									
NC_002945.3	Mycobrowser_v4	CDS	3589641	3590867	.	-	0	Mb3283c	manA		PROBABLE MANNOSE-6-PHOSPHATE ISOMERASE MANA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE)	Mb3283c, manA, len: 408 aa. Equivalent to Rv3255c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Probable manA,mannose-6-phosphate isomerase (EC 5.3.1.8), equivalent to Q9CCJ5|MANA|ML0765 from Mycobacterium leprae (410 aa),FASTA scores: opt: 2271, E(): 1.6e-133, (84.45% identity in 411 aa overlap). Also similar to many e.g. Q9KZL9|MANA from Streptomyces coelicolor (383 aa), FASTA scores: opt: 946, E(): 2.4e-51, (44.4% identity in 403 aa overlap); Q9KV87|VC0269 from Vibrio cholerae (399 aa), FASTA scores: opt: 726, E(): 1.1e-37, (34.15% identity in 404 aa overlap); Q9CMJ5|PMI|PM0829 from Pasteurella multocida (400 aa), FASTA scores: opt: 640, E(): 2.4e-32, (32.5% identity in 391 aa overlap); etc. SIMILAR TO FAMILY 1 OF MANNOSE-6-PHOSPHATE ISOMERASES.	Q7TWW0	No								IPR001250,IPR011051,IPR014710,IPR016305	Q7TWW0	A0A1R3Y3K3									
NC_002945.3	Mycobrowser_v4	CDS	3591912	3593309	.	-	0	Mb3285c	pmma		probable phosphomannomutase pmma (pmm) (phosphomannose mutase)	Mb3285c, manB, len: 465 aa. Equivalent to Rv3257c,len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 465 aa overlap). Probable manB,phosphomannomutase (EC 5.4.2.8) (see citation below),equivalent to Q9CCJ7|PMMA|ML0763 from Mycobacterium leprae (468 aa), FASTA scores: opt: 2533, E(): 2e-145, (83.1% identity in 468 aa overlap). Also similar to many e.g. Q9KZL6|MANB from Streptomyces coelicolor (454 aa), FASTA scores: opt: 1820, E(): 2e-102, (63.2% identity in 459 aa overlap); Q9PGN8|XF0260 from Xylella fastidiosa (500 aa),FASTA scores: opt: 1085, E(): 4.7e-58, (40.7% identity in 462 aa overlap); Q9EY19|MANB from Salmonella enterica subsp. arizonae (456 aa), FASTA scores: opt: 988, E(): 3.1e-52, (38.65% identity in 445 aa overlap); etc. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. Note that previously known as pmmA.	Q7TWV8	No								IPR005841,IPR005843,IPR005844,IPR005845,IPR005846,IPR016055	Q7TWV8	A0A1R3Y3K8									
NC_002945.3	Mycobrowser_v4	CDS	3595143	3596138	.	+	0	Mb3289	fbiA		PROBABLE F420 BIOSYNTHESIS PROTEIN FBIA	Mb3289, fbiA, len: 331 aa. Equivalent to Rv3261,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 331 aa overlap). Probable fbiA, F420 biosynthesis protein, equivalent to FBIA F420 biosynthesis protein fbiA from Mycobacterium bovis BCG (see citations below). Also equivalent, but shorter 46 aa, to Q9CCK1|ML0759 HYPOTHETICAL PROTEIN from Mycobacterium leprae (379 aa), FASTA scores: opt: 1855, E(): 3.9e-110,(79.3% identity in 333 aa overlap). Also similar to others e.g. Q9KZK9|SCE34.17 HYPOTHETICAL 33.6 KDA PROTEIN from Streptomyces coelicolor (319 aa), FASTA scores: opt: 1151,E(): 1.2e-65, (55.1% identity in 332 aa overlap); O29345|AF0917 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (296 aa), FASTA scores: opt: 469,E(): 1.7e-22, (31.15% identity in 302 aa overlap); Q58653|MJ1256 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (311 aa), FASTA scores: opt: 436, E(): 2.2e-20,(27.35% identity in 274 aa overlap); etc.	X2BNV9,Q7TWV4	No	intermediary metabolism and respiration								X2BNV9,Q7TWV4	Q7TWV4				Rv3261		Rv3261			
NC_002945.3	Mycobrowser_v4	CDS	3596135	3597481	.	+	0	Mb3290	fbiB		PROBABLE F420 BIOSYNTHESIS PROTEIN FBIB	Mb3290, fbiB, len: 448 aa. Equivalent to Rv3262,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Probable fbiB, F420 biosynthesis protein, equivalent to FBIB F420 biosynthesis protein fbiB from Mycobacterium bovis BCG (see citations below). Also equivalent to Q9CCK2|ML0758 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (457 aa), FASTA scores: opt: 2411, E(): 3.5e-137, (82.25% identity in 445 aa overlap). Also similar to Q9KZK8|SCE34.18 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (443 aa),FASTA scores: opt: 1180, E(): 2.2e-63, (51.75% identity in 433 aa overlap); other oxidoreductases in C-terminus; and several hypothetical bacterial proteins.	X2BMN4,Q7TWV3	No	intermediary metabolism and respiration								X2BMN4,Q7TWV3	Q7TWV3				Rv3262		Rv3262			
NC_002945.3	Mycobrowser_v4	CDS	3599498	3600577	.	-	0	Mb3292c	manC		d-alpha-d-mannose-1-phosphate guanylyltransferase manb (d-alpha-d-heptose-1-phosphate guanylyltransferase)	Mb3292c, manC, len: 359 aa. Equivalent to Rv3264c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable manC,mannose-1-phosphate guanyltransferase (EC 2.7.7.22),equivalent to Q9CCK6|RMLA2|ML0753 PUTATIVE SUGAR-PHOSPHATE NUCLEOTIDYL TRANSFERASE from Mycobacterium leprae (358 aa), FASTA scores: opt: 2075, E(): 2.7e-115, (86.9% identity in 359 aa overlap). Also similar to others e.g. Q9KZK6|SCE34.20c PUTATIVE NUCLEOTIDE PHOSPHORYLASE from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1314,E(): 2.2e-70, (57.0% identity in 358 aa overlap); Q9KZP4|SC1A8A.08 PUTATIVE MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Streptomyces coelicolor (831 aa),FASTA scores: opt: 699, E(): 8.6e-34, (34.45% identity in 354 aa overlap) (only similarity in N-terminus for this one); P74589|SLL1496 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Synechocystis sp. strain PCC 6803 (843 aa), FASTA scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa overlap) (only similarity in N-terminus for this one too); BAB59222|TVG0079558 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Thermoplasma volcanium (359 aa), FASTA scores: opt: 664, E(): 5.2e-32, (34.6% identity in 338 aa overlap); Q9ZTW5|GMP GDP-MANNOSE PYROPHOSPHORYLASE from Solanum tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E(): 2.3e-30, (34.65% identity in 361 aa overlap); etc. BELONGS TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that previously known as rmlA2.	Q7TWV1	No								IPR001451,IPR005835	Q7TWV1	A0A1R3Y3L4									
NC_002945.3	Mycobrowser_v4	CDS	3601483	3602397	.	-	0	Mb3294c	rmlD		dtdp-6-deoxy-l-lyxo-4-hexulose reductase rmld (dtdp-rhamnose modification protein) (dtdp-rhamnose biosynthesis protein) (dtdp-rhamnose synthase)	Mb3294c, rmld, len: 304 aa. Equivalent to Rv3266c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 304 aa overlap). Possible rmld,dTDP-rhamnose modification protein, highly similar to Q9CCK8 putative dTDP-rhamnose modification protein from Mycobacterium leprae (311 aa), FASTA scores, opt: 1440,E(): 1.1e-78, (74.7% identity in 312 aa overlap); and similar to several dtdp-4-dehydrorhamnose reductase (EC 1.1.1.133) e.g. STRL_STRGR|P29781 from Streptomyces griseus (304 aa), FASTA scores, opt: 788, E(): 0, (47.4% identity in 304 aa overlap).	Q7TWV0	No								IPR005913,IPR016040	Q7TWV0	A0A1R3Y3M5									
NC_002945.3	Mycobrowser_v4	CDS	3635845	3636612	.	+	0	Mb3325	nei		PROBABLE ENDONUCLEASE VIII NEI	Mb3325, nei, len: 255 aa. Equivalent to Rv3297,len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 255 aa overlap). Probable nei,endonuclease VIII (EC 3.2.-.-), similar to others e.g. O86820|END8_STRCO|NEI|SC7C7.15c from Streptomyces coelicolor (276 aa), FASTA scores: opt: 770, E(): 1.2e-42,(50.35% identity in 268 aa overlap); P50465|END8_ECOLI|NEI|B0714 from Escherichia coli strain K12 (262 aa), FASTA scores: opt: 310, E(): 6.3e-13, (28.1% identity in 267 aa overlap); AAG55037|NEI from Escherichia coli strain O157:H7 EDL933 (263 aa), FASTA scores: opt: 301, E(): 2.4e-12, (27.7% identity in 267 aa overlap); etc. BELONGS TO THE FPG FAMILY.	X2BMS5,P64157	No	information pathways								X2BMS5,P64157	P64157				Rv3297		Rv3297			
NC_002945.3	Mycobrowser_v4	CDS	3605114	3607270	.	+	0	Mb3298	ctpC		PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C CTPC	Mb3298, ctpC, len: 718 aa. Equivalent to Rv3270,len: 718 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 718 aa overlap). Probable ctpC, metal cation-transport ATPase P-type (EC 3.6.3.-), integral membrane protein, equivalent to Q9CCL1|CTPC|ML0747 PUTATIVE CATION TRANSPORT ATPASE from Mycobacterium leprae (725 aa), FASTA scores: opt: 3908, E(): 0, (85.95% identity in 713 aa overlap). Also similar to O66027|MTAA METAL TRANSPORTING ATPASE MTA72 from Mycobacterium tuberculosis (680 aa), FASTA scores: opt: 3756, E(): 5.5e-213, (91.45% identity in 679 aa overlap); and to other ATPases e.g. Q9ZHC7|SILP_SALTY PUTATIVE CATION TRANSPORTING P-TYPE ATPASE from Salmonella typhimurium (824 aa), FASTA scores: opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa overlap); Q9HX93|PA3920 PROBABLE METAL TRANSPORTING P-TYPE ATPASE from Pseudomonas aeruginosa (792 aa), FASTA scores: opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.	X2BNH2,P0A503	No	cell wall and cell processes								X2BNH2,P0A503	P0A503				Rv3270		Rv3270			
NC_002945.3	Mycobrowser_v4	CDS	3631300	3635841	.	+	0	Mb3324	lhr		PROBABLE ATP-DEPENDENT HELICASE LHR (LARGE HELICASE-RELATED PROTEIN)	Mb3324, lhr, len: 1513 aa. Equivalent to Rv3296,len: 1512 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1512 aa overlap). Probable lhr,ATP-dependent helicase (EC 3.6.1.-), similar to others e.g. P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.55% identity in 1569 aa overlap); AAG56642|LHR from Escherichia coli stain O157:H7 EDL933 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.6% identity in 1561 aa overlap); O86821|SC7C7.16c from Streptomyces coelicolor (1690 aa), FASTA scores: opt: 2919, E(): 7e-159, (53.55% identity in 1703 aa overlap); Q9HYW9|PA3272 from Pseudomonas aeruginosa (1448 aa), FASTA scores: opt: 907, E(): 6.2e-44, (35.85% identity in 1512 aa overlap); etc. SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND TO HELICASE C-TERMINAL DOMAIN. Contains PS00017 ATP/GTP-binding site motif A and possible helix-turn-helix motif.	Q7TWS8	No	information pathways							IPR001650,IPR003593,IPR011545,IPR013701,IPR014001,IPR027417	Q7TWS8	A0A1R3Y3R0				Rv3296		Rv3296			
NC_002945.3	Mycobrowser_v4	CDS	3611508	3612677	.	-	0	Mb3302c	fadE25		PROBABLE ACYL-COA DEHYDROGENASE FADE25	Mb3302c, fadE25, len: 389 aa. Equivalent to Rv3274c, len: 389 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 389 aa overlap). Probable fadE25, Acyl-CoA Dehydrogenase (EC 1.3.99.-),equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE ACYL-COA DEHYDROGENASE FADE25 from Mycobacterium leprae (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05% identity in 389 aa overlap). Also similar to many e.g. Q9RIQ5|FADE FATTY ACID ACYL-COA DEHYDROGENASE from Streptomyces lividans (385 aa), FASTA scores: opt: 1692,E(): 4.9e-99, (67.35% identity in 383 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in 376 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 1209, E(): 1.1e-68, (51.7% identity in 377 aa overlap); P52042|ACDS_CLOAB|BCD from Clostridium acetobutylicum (379 aa), FASTA scores: opt: 1056, E(): 4.6e-59, (44.6% identity in 379 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.	X2BN17,P63428	No	lipid metabolism								X2BN17,P63428	P63428				Rv3274c		Rv3274c			
NC_002945.3	Mycobrowser_v4	CDS	3612702	3613226	.	-	0	Mb3303c	purE		PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT PURE (AIR CARBOXYLASE) (AIRC)	Mb3303c, purE, len: 174 aa. Equivalent to Rv3275c,len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 174 aa overlap). Probable purE,phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21), equivalent to P46702|PUR6_MYCLE|PURE|ML0736|B1308_F3_98 from Mycobacterium leprae (171 aa), FASTA scores: opt: 878,E(): 1.5e-43, (81.55% identity in 168 aa overlap). Also similar to others e.g. Q9AXD0|AIRC from Nicotiana tabacum (Common tobacco) (623 aa), FASTA scores: opt: 712, E(): 1.4e-33, (69.35% identity in 160 aa overlap) (similarity in C-terminal part for this one); Q44679|PUR6_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (177 aa), FASTA scores: opt: 651, E(): 1.5e-30, (68.25% identity in 148 aa overlap); Q55498|PUR6_SYNY3|PURE|SLL0901 from Synechocystis sp. strain PCC 6803 (176 aa), FASTA scores: opt: 639, E(): 7.1e-30, (60.5% identity in 167 aa overlap); etc.	Q7TWU3	No								IPR000031,IPR024694	Q7TWU3	A0A1R3Y3M8									
NC_002945.3	Mycobrowser_v4	CDS	3613223	3614512	.	-	0	Mb3304c	purK		PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT PURK (AIR CARBOXYLASE) (AIRC)	Mb3304c, purK, len: 429 aa. Equivalent to Rv3276c,len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 429 aa overlap). Probable purK,phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21), equivalent to P46701|PURK_MYCLE|ML0735|B1308_F1_32 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT from Mycobacterium leprae (439 aa), FASTA scores: opt: 2168, E(): 2.3e-123, (76.15% identity in 444 aa overlap). Also similar to others e.g. Q44678|PURK_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (413 aa), FASTA scores: opt: 1179, E(): 9.1e-64, (48.35% identity in 389 aa overlap); Q9KZ85|PURK from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1150, E(): 4.7e-62, (55.35% identity in 345 aa overlap); Q54975|PURK_SYNP7 from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (395 aa), FASTA scores: opt: 772,E(): 3e-39, (38.1% identity in 383 aa overlap); etc. BELONGS TO THE PURK / PURT FAMILY.	X2BNX8,P65899	No									X2BNX8,P65899	P65899									
NC_002945.3	Mycobrowser_v4	CDS	3615800	3616600	.	-	0	Mb3307c	birA		POSSIBLE BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGASE)	Mb3307c, birA, len: 266 aa. Equivalent to Rv3279c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 266 aa overlap). Possible birA,bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15),equivalent to Q9CCL3|BIRA|ML0732 BIOTIN APO-PROTEIN LIGASE from Mycobacterium leprae (274 aa), FASTA scores: opt: 1189, E(): 2.3e-66, (71.2% identity in 271 aa overlap). But as it lacks a BirA h-t-h domain at N-terminus, may simply be biotin apo-protein ligase. Also similar to others e.g. Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312 aa), FASTA scores: opt: 347, E(): 2.7e-14, (32.95% identity in 270 aa overlap); Q9HWC0|BIRA|PA4280 from Pseudomonas aeruginosa (312 aa), FASTA scores: opt: 335,E(): 1.5e-13, (34.2% identity in 272 aa overlap); Q9A6Z0|CC1936 from Caulobacter crescentus (250 aa), FASTA scores: opt: 332, E(): 1.9e-13, (33.6% identity in 238 aa overlap); P06709|BIRA_ECOLI (321 aa), FASTA scores: opt: 314, E(): 3.1e-12, (34.15% identity in 249 aa overlap); etc. SIMILAR WITH OTHER BACTERIAL BIRA AND WITH EUKARYOTIC BIOTIN APO-PROTEIN LIGASE.	Q7TWU0	No								IPR003142,IPR004143,IPR004408	Q7TWU0	A0A1R3Y4E2									
NC_002945.3	Mycobrowser_v4	CDS	3619453	3620346	.	+	0	Mb3311	sseA		PROBABLE THIOSULFATE SULFURTRANSFERASE SSEA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)	Mb3311, sseA, len: 297 aa. Equivalent to Rv3283,len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 297 aa overlap). Probable sseA,thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 PUTATIVE THIOSULFATE SULFURTRANSFERASE SSEA from Mycobacterium leprae (296 aa), FASTA scores: opt: 1742, E(): 5.5e-108,(83.45% identity in 296 aa overlap). Also highly similar to others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1057, E(): 1.2e-62, (53.86% identity in 273 aa overlap); P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1006, E(): 2.7e-59, (51.25% identity in 277 aa overlap); P71121|THTR_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (225 aa), FASTA scores: opt: 897, E(): 3.6e-52, (59.05% identity in 215 aa overlap); etc. Also highly similar to O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c|M T0837|MTV043.07c|THTR_MYCTU PUTATIVE THIOSULFATE SULFURTRANSFERASE (EC 2.8.1.1) from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 955, E(): 6.3e-56, (50.2% identity in 271 aa overlap); and Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium leprae (277 aa),FASTA scores: opt: 931, E(): 2.5e-54, (48.9% identity in 276 aa overlap). Shows some similarity to MTCY339.19c (30.3% identity in 254 aa overlap). Contains PS00683 Rhodanese C-terminal signature. BELONGS TO THE RHODANESE FAMILY.	X2BN61,Q7TWT6	No	intermediary metabolism and respiration								X2BN61,Q7TWT6	Q7TWT6				Rv3283		Rv3283			
NC_002945.3	Mycobrowser_v4	CDS	3623476	3623913	.	-	0	Mb3315c	rsbW		ANTI-SIGMA FACTOR RSBW (SIGMA NEGATIVE EFFECTOR)	Mb3315c, rsbW, len: 145 aa. Equivalent to Rv3287c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 145 aa overlap). rsbW (alternate gene name: usfX), anti-sigma factor (see citations below),similar to Q49667|B1308_F3_89 from Mycobacterium leprae (75 aa), FASTA scores: opt: 308, E(): 2.5e-15, (72.2% identity in 72 aa overlap); Q9R3X8|PRS1|USHX|PRS PRS1 PROTEIN (ANTI-SIGMA FACTOR) from Streptomyces coelicolor (137 aa), FASTA scores: opt: 184, E(): 3.7e-06, (36.8% identity in 106 aa overlap); O50231 PUTATIVE SIGMA-B REGULATOR from Bacillus licheniformis (160 aa), FASTA scores: opt: 122, E(): 0.13, (23.9% identity in 92 aa overlap); and P17904|RSBW_BACSU ANTI-SIGMA B FACTOR (SIGMA-B NEGATIVE EFFECTOR RSBW) from Bacillus subtilis (160 aa), FASTA scores: opt: 108, E(): 1.3, (21.25% identity in 127 aa overlap). Equivalent to AAK47729 from Mycobacterium tuberculosis strain CDC1551 (145 aa) but longer 99 aa. INDUCTION BY HEAT SHOCK, SALT STRESS,OXIDATIVE STRESS, GLUCOSE LIMITATION AND OXYGEN LIMITATION. N-terminus shortened since first submission (previously 242 aa).	Q7TWT4	No									Q7TWT4	A0A1R3Y3P6									
NC_002945.3	Mycobrowser_v4	CDS	3624970	3626319	.	-	0	Mb3318c	lat		PROBABLE L-LYSINE-EPSILON AMINOTRANSFERASE LAT (L-LYSINE AMINOTRANSFERASE) (LYSINE 6-AMINOTRANSFERASE)	Mb3318c, lat, len: 449 aa. Equivalent to Rv3290c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable lat,lysine-epsilon aminotransferase (EC 2.6.1.36), similar to Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa),FASTA scores: opt: 1702, E(): 1.1e-99, (60.35% identity in 439 aa overlap); and Q01767|Q53823|LAT_STRCL from Streptomyces clavuligerus (457 aa), FASTA scores: opt: 1676, E(): 4.9e-98, (60.15% identity in 434 aa overlap). Also some similarity to 4-AMINOBUTYRATE AMINOTRANSFERASE PROTEINS (GAMMA-AMINO-N-BUTYRATE TRANSAMINASES). BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE.	X2BNI6,P63510	No									X2BNI6,P63510	P63510									
NC_002945.3	Mycobrowser_v4	CDS	3616650	3618296	.	+	0	Mb3308	accD5		PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 ACCD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)	Mb3308, accD5, len: 548 aa. Equivalent to Rv3280,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 548 aa overlap). Probable accD5,propyonyl-CoA carboxylase beta chain 5 (EC 6.4.1.3),equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 from Mycobacterium leprae (549 aa), FASTA scores: opt: 3241,E(): 4e-192, (88.7% identity in 549 aa overlap). Also similar to many e.g. O87201|DTSR2 DTSR2 PROTEIN INVOLVED IN GLUTAMATE PRODUCTION from orynebacterium glutamicum (Brevibacterium flavum) (537 aa), FASTA scores: opt: 2604,E(): 6.9e-153, (74.1% identity in 529 aa overlap) (see first citation below); P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa), FASTA scores: opt: 2466, E(): 2.2e-144, (70.2% identity in 530 aa overlap); O88155|DTSR1 DTSR1 PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (543 aa), FASTA scores: opt: 2375, E(): 8.8e-139, (67.1% identity in 529 aa overlap (see citation below); Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA scores: opt: 2360, E(): 7.3e-138, (67.9% identity in 533 aa overlap); O24789|MXPCCB from Myxococcus xanthus (524 aa), FASTA scores: opt: 1868, E(): 1.5e-107, (56.85% identity in 524 aa overlap); etc. Also similar with METHYLMALONYL-COA DECARBOXYLASES e.g. O59018|PH1287 from Pyrococcus horikoshii (522 aa), FASTA scores: opt: 1841,E(): 6.7e-106, (54.15% identity in 528 aa overlap). Also similarity with MTCY427.28 (43.8% identity in 434 aa overlap). BELONGS TO THE ACCD/PCCB FAMILY.	Q7TWT9	No								IPR000022,IPR011762,IPR011763	Q7TWT9	A0A1R3Y3U0									
NC_002945.3	Mycobrowser_v4	CDS	3618277	3618747	.	+	0	Mb3309	acce5		probable bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (epsilon chain) acce5	Mb3309, -, len: 156 aa. Similar to Rv3281, len: 177 aa, from Mycobacterium tuberculosis strain H37Rv, (88.1% identity in 177 aa overlap). Conserved hypothetical protein, equivalent (but longer 14 aa and with a gap between aa 82-102) to AAK47723|MT3380 from Mycobacterium tuberculosis strain CDC1551 (142 aa), FASTA scores: opt: 830, E(): 3.1e-40, (86.5% identity in 163 aa overlap). C-terminus highly similar to Q49671|B1308_C3_211|ML0730 from Mycobacterium leprae (84 aa), FASTA scores: opt: 393,E(): 7.6e-16, (68.95% identity in 87 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177 aa).	Q7TWT8	No									Q7TWT8	A0A1R3Y3Y2									
NC_002945.3	Mycobrowser_v4	CDS	3622694	3623479	.	-	0	Mb3314c	sigF		alternative rna polymerase sigma factor sigf	Mb3314c, sigF, len: 261 aa. Equivalent to Rv3286c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable sigF, stress response/stationary phase RNA polymerase sigma factor (see citations below), similar to several Streptomyces RNA polymerase sigma factors e.g. Q9RPC8|SIGH from Streptomyces coelicolor A3(2) (354 aa), FASTA scores: opt: 869, E(): 1.1e-45, (51.15% identity in 258 aa overlap); Q9RIT0|SIG1 from Streptomyces coelicolor (361 aa), FASTA scores: opt: 869, E(): 1.1e-45, (51.15% identity in 258 aa overlap); Q9ADM4|2SC10A7.38c from Streptomyces coelicolor (318 aa), FASTA scores: opt: 776, E(): 4.6e-40, (48.75% identity in 240 aa overlap); P37971|RPOF_STRCO|SIGF|RPOX|2SCD60.01c from Streptomyces coelicolor (287 aa), FASTA scores: opt: 717, E(): 1.6e-36,(44.5% identity in 245 aa overlap); P37970|RPOF_STRAU|SIGF|RPOX from Streptomyces aureofaciens (297 aa); etc. Contains possible helix-turn-helix motif at aa 229-250 (+7.38 SD). SIMILAR TO THE SIGMA-70 FACTOR FAMILY. Seems expressed in stationary phase and under stress conditions in vitro (see citations below).	P96891	No								IPR000943,IPR007624,IPR007627,IPR007630,IPR011991,IPR013324,IPR013325,IPR014284,IPR014322	P96891	A0A1R3Y3Q3									
NC_002945.3	Mycobrowser_v4	CDS	3628127	3629611	.	+	0	Mb3321	pcd		PROBABLE PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE)	Mb3321, pcd, len: 494 aa. Equivalent to Rv3293,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 494 aa overlap). Probable pcd,piperideine-6-carboxylic acid dehydrogenase (EC 1.5.-.-),highly similar to others e.g. O85725|PCD SEMIALDEHYDE DEHYDROGENASE from Streptomyces clavuligerus (512 aa),FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity in 496 aa overlap) (see first citation below); Q9I4U7|PA1027 PROBABLE ALDEHYDE DEHYDROGENASE from Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984,E(): 1.4e-107, (64.5% identity in 493 aa overlap); BAB49892|MLL2867 ALDEHYDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 1964, E(): 2e-106, (62.8% identity in 476 aa overlap); Q9A8Y1|CC1216 ALDEHYDE DEHYDROGENASE from Caulobacter crescentus (507 aa), FASTA scores: opt: 1909, E(): 3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE from Streptomyces clavuligerus (496 aa), FASTA scores: opt: 1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap); and Q9F1U8|PCD PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE from 'Flavobacterium' lutescens (510 aa), FASTA scores: opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa overlap) (see second citation below); etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Note that ORF Rv3290c seems to encoded the putative lat enzyme. Previously known as aldB.	Q7TWT1	No	intermediary metabolism and respiration							IPR015590,IPR016160,IPR016161,IPR016162,IPR016163	Q7TWT1	A0A1R3Y3Q7				Rv3293		Rv3293			
NC_002945.3	Mycobrowser_v4	CDS	3917726	3918511	.	-	0	Mb3566c	hsae		PROBABLE HYDRATASE	Mb3566c, -, len: 261 aa. Equivalent to Rv3536c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Probable hydratase,2-oxo-hepta-3-ene-1,7-dioate hydratase (EC 4.2.1.-) or 2-keto-4-pentenoate hydratase (EC 4.2.1.-). Indeed, highly similar to many 2-oxo-hepta-3-ene-1,7-dioate hydratases e.g. Q9CKS2|HPAH|PM1534 from Pasteurella multocida (267 aa) FASTA scores: opt: 743, E(): 1.5e-39, (45.5% identity in 266 aa overlap) Q9RZ31|DRA0122 from Deinococcus radiodurans (268 aa), FASTA scores: opt: 709, E(): 2e-37,(45.5% identity in 266 aa overlap); Q9HWQ4|HPCG|PA4127 from Pseudomonas aeruginosa (267 aa), FASTA scores: opt: 703, E(): 4.8e-37, (45.1% identity in 266 aa overlap); Q46982|HPAH|HPCG from Escherichia colis strain ATCC 11105 (267 aa), FASTA scores: opt: 679, E(): 1.6e-35, (41.35% identity in 266 aa overlap); etc. But also highly similar to many 2-keto-4-pentenoate hydratases (2-hydroxypentadienoic acidhydratases) e.g. Q9LAF7|PHED from Bacillus thermoglucosidasius (258 aa), FASTA scores: opt: 698, E(): 9.7e-37, (42.45% identity in 252 aa overlap); Q52442|BPHH from Pseudomonas sp (260 aa) FASTA scores: opt: 675, E(): 2.7e-35, (41.4% identity in 251 aa overlap); P77608|MHPD_ECOLI|B0350 from Escherichia coli strain K12 (269 aa), FASTA scores: opt: 674, E(): 3.2e-35,(42.75% identity in 255 aa overlap); Q52038|BPHX1 from Pseudomonas pseudoalcaligenes (260 aa), FASTA scores: opt: 663, E(): 1.5e-34, (40.6% identity in 251 aa overlap); etc.	Q7TW96	No	intermediary metabolism and respiration							IPR002529,IPR011234	Q7TW96	A0A1R3Y4E3				Rv3536c		Rv3536c			
NC_002945.3	Mycobrowser_v4	CDS	3636635	3637549	.	-	0	Mb3326c	lpqC		POSSIBLE ESTERASE LIPOPROTEIN LPQC	Mb3326c, lpqC, len: 304 aa. Equivalent to Rv3298c,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Possible lpqC,esterase lipoprotein (EC 3.1.-.-), equivalent to Q9CCL5|LPQC|ML0715 PUTATIVE SECRETED HYDROLASE from Mycobacterium leprae (304 aa), FASTA scores: opt: 1543,E(): 1.3e-87, (71.6% identity in 303 aa overlap); and Q49658|B1308_F2_43 TUBULIN FAMILY PROTEIN from Mycobacterium leprae (302 aa), FASTA scores: opt: 1541,E(): 1.7e-87, (72.0% identity in 300 aa overlap). Also similar to Q9I5Z3|PA0543 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (322 aa), FASTA scores: opt: 439,E(): 8.9e-20, (32.3% identity in 319 aa overlap); Q9F2K9|SCH63.19c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (348 aa), FASTA scores: opt: 394,E(): 5.5e-17, (30.25% identity in 334 aa overlap); etc. And similar to O86367|LPQP|Rv0671|MTCI376.03c from Mycobacterium tuberculosis strain H37Rv (280 aa), FASTA scores: opt: 519, E(): 9.8e-25, (39.25% identity in 275 aa overlap). Probably lipoprotein, esterase membrane-bound,with 18 aa signal sequence as it contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site.	Q7TWS7	No									Q7TWS7	A0A1R3Y5I1									
NC_002945.3	Mycobrowser_v4	CDS	3637576	3640488	.	-	0	Mb3327c	atsB		PROBABLE ARYLSULFATASE ATSB (ARYL-SULFATE SULPHOHYDROLASE) (SULFATASE)	Mb3327c, atsB, len: 970 aa. Equivalent to Rv3299c,len: 970 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 970 aa overlap). Probable atsB,arylsulfatase (EC 3.1.6.1), similar to P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from Pseudomonas aeruginosa (535 aa), FASTA scores: opt: 645,E(): 5.8e-31, (32.0% identity in 550 aa overlap); Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa), FASTA scores: opt: 504, E(): 1.7e-22, (26.3% identity in 566 aa overlap); and P20713|ATSA|ARS_KLEAE (precursor) from Klebsiella pneumoniae (464 aa), FASTA scores: opt: 502,E(): 1.8e-22, (26.85% identity in 451 aa overlap). Also similar to Mycobacterium tuberculosis proteins O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6% identity in 796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa) (38.4% identity in 797 aa overlap). Equivalent to AAK47741 from Mycobacterium tuberculosis strain CDC1551 (992 aa) but shorter 22 aa. Contains PS00523 Sulfatases signature 1 and PS01095 Chitinases family 18 active site signature. BELONGS TO THE SULFATASE FAMILY.	Q7TWS6	No								IPR000917,IPR009200,IPR017849,IPR017850,IPR024607	Q7TWS6	A0A1R3Y4G2									
NC_002945.3	Mycobrowser_v4	CDS	3641437	3642102	.	-	0	Mb3329c	phoY1		PROBABLE PHOSPHATE-TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PHOU HOMOLOG 1 PHOY1	Mb3329c, phoY1, len: 221 aa. Equivalent to Rv3301c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable phoY1,phosphate-transport system regulatory protein, highly similar to Q50047|phoY|PHOU1|PHOY1|ML2188 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 1 from Mycobacterium leprae (222 aa), FASTA scores: opt: 929, E(): 7.8e-51,(61.45% identity in 218 aa overlap). Also highly similar to Q9FCE2|2SCD46.42c PUTATIVE REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (123 aa), FASTA scores: opt: 324, E(): 1.8e-13, (43.65% identity in 103 aa overlap); Q9L0R3|SCD8A.01c PUTATIVE PHOSPHATE TRANSPORT SYSTEM REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (139 aa), FASTA scores: opt: 309, E(): 1.7e-12,(36.7% identity in 139 aa overlap); Q52989|PHOU_RHIME PHOSPHATE TRANSPORT SYSTEM PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (237 aa), FASTA scores: opt: 292,E(): 3.1e-11, (26.3% identity in 213 aa overlap); etc. And highly similar to Mycobacterium tuberculosis O53833|PHU2_MYCTU|MTV043_13c|PHOU2|PHOY2|Rv0821c|MT0843 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (213 aa) (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY.	X2BP11,P65719	No									X2BP11,P65719	P65719									
NC_002945.3	Mycobrowser_v4	CDS	3642210	3643967	.	-	0	Mb3330c	glpD2		PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLPD2	Mb3330c, glpD2, len: 585 aa. Equivalent to Rv3302c,len: 585 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 585 aa overlap). Probable glpd2,glycerol-3-phosphate dehydrogenase (EC 1.1.99.5),equivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 GLYCEROL-3-PHOSPHATE DEHYDROGENASE (EC 1.1.99.5) from Mycobacterium leprae (585 aa), FASTA scores: opt: 3489,E(): 2.2e-198, (90.75% identity in 584 aa overlap). Also highly similar to many e.g. Q9L0I3|SCD63.06 from Streptomyces coelicolor (568 aa), FASTA scores: opt: 2203,E(): 1.6e-122, (59.95% identity in 564 aa overlap); Q9RVK8|DR1019 from Deinococcus radiodurans (522 aa), FASTA scores: opt: 949, E(): 1.4e-48, (37.0% identity in 538 aa overlap); BAB53412|MLR7270 from Rhizobium loti (Mesorhizobium loti) (505 aa), FASTA scores: opt: 861,E(): 2.2e-43, (37.3% identity in 488 aa overlap); P18158|GLPD_BACSU from B. subtilis (555 aa), FASTA scores: opt: 768, E(): 7.2e-38, (32.85% identity in 484 aa overlap); etc. Also similar to Mycobacterium tuberculosis protein Q10502|GLPD_MYCTU|MTCY427_31c|Rv2249c GLYCEROL-3-PHOSPHATE DEHYDROGENASE (516 aa), FASTA scores: opt: 843, E(): 2.6e-42, (36.5% identity in 515 aa overlap). Contains PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. COFACTOR: FAD (BY SIMILARITY). BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY.	X2BMT2,P64185	No									X2BMT2,P64185	P64185									
NC_002945.3	Mycobrowser_v4	CDS	3655612	3656709	.	-	0	Mb3342c	add		PROBABLE ADENOSINE DEAMINASE ADD (ADENOSINE AMINOHYDROLASE)	Mb3342c, add, len: 365 aa. Equivalent to Rv3313c,len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 365 aa overlap). Probable add,adenosine deaminase (EC 3.5.4.4), equivalent to Q9CCL9|ADD|ML0700 PUTATIVE ADENOSINE DEAMINASE from Mycobacterium leprae (362 aa), FASTA scores: opt: 2097,E(): 1.4e-127, (88.2% identity in 356 aa overlap) . Also similar to many e.g. Q9AK25|2SCK8.27 from Streptomyces coelicolor (396 aa), FASTA scores: opt: 1578, E(): 3.7e-94, (66.65% identity in 360 aa overlap); Q17747|C06G3.5 from Caenorhabditis elegans (349 aa), FASTA scores: opt: 435, E(): 1.1e-20, (29.6% identity in 348 aa overlap); P22333|ADD_ECOLI|B1623 from Escherichia coli strain K12 (333 aa), FASTA scores: opt: 380, E(): 3.7e-17,(29.4% identity in 340 aa overlap); etc. BELONGS TO THE ADENOSINE AND AMP DEAMINASES FAMILY.	X2BN49,P63908	No									X2BN49,P63908	P63908									
NC_002945.3	Mycobrowser_v4	CDS	3644048	3645463	.	-	0	Mb3331c	lpdA		nad(p)h quinone reductase lpda	Mb3331c, lpdA, len: 471 aa. Equivalent to Rv3303c,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 471 aa overlap). Probable lpdA,dihydrolipoamide dehydrogenase (EC 1.8.1.4), similar to other e.g. Q9EWV3|2SCK31.22c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1420,E(): 2.4e-77, (54.9% identity in 471 aa overlap); Q9A7J2|CC1731 LIPOAMIDE DEHYDROGENASE (E3 COMPONENT,PYRUVATE DEHYDROGENASE COMPLEX) from Caulobacter crescentus (466 aa), FASTA scores: opt: 696, E(): 3.6e-34,(29.6% identity in 463 aa overlap); Q04829|LPD|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE from Halobacterium volcanii (Haloferax volcanii) (474 aa), FASTA scores: opt: 675,E(): 6.5e-33, (29.3% identity in 471 aa overlap); P50970|DLDH_ZYMMO|LPD DIHYDROLIPOAMIDE DEHYDROGENASE from Zymomonas mobilis, FASTA scores: opt: 658, E(): 6.6e-32,(30.4% identity in 464 aa overlap); etc. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD (BY SIMILARITY). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation due to a single base transversion (c-a) results in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (471 aa versus 493 aa).	Q7TWS4	No								IPR001327,IPR004099,IPR013027,IPR016156,IPR023753	Q7TWS4	A0A1R3Y3R8									
NC_002945.3	Mycobrowser_v4	CDS	3646164	3647333	.	-	0	Mb3333c	amiA1		possible n-acyl-l-amino acid amidohydrolase amia1 (n-acyl-l-amino acid aminohydrolase)	Mb3333c, amiA1, len: 389 aa. Equivalent to Rv3305c,len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 389 aa overlap). Possible amiA1,N-acyl-L-amino acid amidohydrolase (or peptidase) (EC 3.5.1.-), similar to many proteins e.g. Q9AK43|2SCK8.09 PUTATIVE PEPTIDASE from Streptomyces coelicolor (410 aa),FASTA scores: opt: 1015, E(): 3.9e-54, (50.8% identity in 374 aa overlap); Q9UZ30|PAB0873 AMINO ACID AMIDOHYDROLASE from Pyrococcus abyssi (383 aa), FASTA scores: opt: 823,E(): 1.6e-42, (38.2% identity in 369 aa overlap); O58453|PH0722 LONG HYPOTHETICAL AMINO ACID AMIDOHYDROLASE from Pyrococcus horikoshii (388 aa), FASTA scores: opt: 815, E(): 4.8e-42, (38.75% identity in 369 aa overlap); O34980|YTNL_BACSU HYPOTHETICAL 45.2 KDA PROTEIN from B. subtilis (416 aa), FASTA scores: opt: 805, E(): 2.1e-41,(37.85% identity in 367 aa overlap); Q9KCF8|BH1613 N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Bacillus halodurans (404 aa), FASTA scores: opt: 795, E(): 8.1e-41,(37.7% identity in 382 aa overlap); BAB50445|MLR3583 HYPOTHETICAL HIPPURATE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (387 aa), FASTA scores: opt: 761,E(): 8.9e-39, (37.65% identity in 385 aa overlap); Q9RXH4|DR0339 PUTATIVE N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Deinococcus radiodurans (392 aa), FASTA scores: opt: 745, E(): 8.4e-38, (36.15% identity in 379 aa overlap); etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. Note that previously known as amiA.	Q7TWS2	No								IPR002933,IPR011650,IPR017439	Q7TWS2	A0A1R3Y3R4									
NC_002945.3	Mycobrowser_v4	CDS	3647330	3648514	.	-	0	Mb3334c	amiB1		probable amidohydrolase amib1 (aminohydrolase)	Mb3334c, amiB1, len: 394 aa. Equivalent to Rv3306c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 394 aa overlap). Probable amiB1,aminohydrolase (EC 3.5.1.-), similar to several belonging to peptidase family M40 (and to hypothetical proteins) e.g. P54983|AMHX_BACSU AMIDOHYDROLASE AMHX from Bacillus subtilis (EC 3.5.1.-) (389 aa), FASTA scores: opt: 286,E(): 9.9e-10, (26.6% identity in 351 aa overlap); P76052|ABGB_ECOLI Aminobenzoyl-glutamate utilizatio from Escherichia coli (481 aa), FASTA scores: opt: 383, E(): 2.1e-15, (30.5% identity in 328 aa overlap); P44765|YDAJ_HAEIN HYPOTHETICAL PROTEIN HI0584 from Haemophilus influenzae (423 aa), FASTA scores: opt: 297,E(): 2.4e-10, (29.6% identity in 274 aa overlap). Note that previously known as amiB.	Q7TWS1	No								IPR002933,IPR011650,IPR017144,IPR017439	Q7TWS1	A0A1R3Y3S2									
NC_002945.3	Mycobrowser_v4	CDS	3648579	3649385	.	+	0	Mb3335	deoD		PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE DEOD (INOSINE PHOSPHORYLASE) (PNP)	Mb3335, deoD, len: 268 aa. Equivalent to Rv3307,len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Probable deoD (alternate gene name: punA), purine nucleoside phosphorylase (EC 2.4.2.1), similar to others especially P46862|PUNA_MYCLE|DEOD_MYCLE|ML0707|L308_F2_56 from M. leprae (268 aa), FASTA scores: opt: 1373, E(): 1.5e-74,(82.05% identity in 262 aa overlap); Q9EWV2|2SCK31.24 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 1026,E(): 6.4e-54, (60.5% identity in 266 aa overlap); P81989|PUNA_CELSP from Cellulomonas sp (282 aa), FASTA scores: opt: 963, E(): 3.6e-50, (58.9% identity in 270 aa overlap); Q9X1T2|TM1596 from Thermotoga maritima (265 aa),FASTA scores: opt: 584, E(): 1.1e-27, (39.55% identity in 263 aa overlap); etc. BELONGS TO THE PNP/MTAP FAMILY 2 OF PHOSPHORYLASES.	X2BMT9,P0A539	No	intermediary metabolism and respiration								X2BMT9,P0A539	P0A539				Rv3307		Rv3307			
NC_002945.3	Mycobrowser_v4	CDS	3649389	3650993	.	+	0	Mb3336	pmmB		PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE)	Mb3336, pmmB, len: 534 aa. Equivalent to Rv3308,len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 534 aa overlap). Probable pmmB,phosphomannomutase (EC 5.4.2.8), equivalent to Q9CCL7|PMMB|ML0706 PUTATIVE PHOSPHO-SUGAR MUTASE from Mycobacterium leprae (538 aa), FASTA scores: opt: 2681,E(): 1.4e-150, (76.95% identity in 538 aa overlap). Also similar to others e.g. Q9AD82|SCK13.08c from Streptomyces coelicolor (549 aa), FASTA scores: opt: 1378, E(): 8.9e-74, (46.7% identity in 529 aa overlap); Q9ZHL4|PMM (FRAGMENT so no homology at N-terminus for this one) from Haemophilus ducreyi (443 aa), FASTA scores: opt: 935, E(): 9.6e-48, (39.4% identity in 449 aa overlap); P18159|YHXB_BACSU from Bacillus subtilis (565 aa), FASTA scores: opt: 776, E(): 2.7e-38, (31.7% identity in 574 aa overlap); etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY.	Q7TWS0	No	intermediary metabolism and respiration							IPR005841,IPR005843,IPR005844,IPR005845,IPR005846,IPR016055,IPR016066	Q7TWS0	A0A1R3Y5J3				Rv3308		Rv3308			
NC_002945.3	Mycobrowser_v4	CDS	3650995	3651711	.	-	0	Mb3337c	upp		PROBABLE URACIL PHOSPHORIBOSYLTRANSFERASE UPP (UMP PYROPHOSPHORYLASE) (UPRTASE) (UMP DIPHOSPHORYLASE)	Mb3337c, upp, len: 238 aa. Equivalent to Rv3309c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,with 5' extension identified by de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Probable upp,uracil phosphoribosyltransferase (EC 2.4.2.9). Also similar to others e.g. P36399|UPP_STRSL from Streptococcus salivarius (209 aa),Q9A194|UPP|SPY0392 from Streptococcus pyogenes (209 aa), Q9RE01|UPP from Lactobacillus plantarum (209 aa), etc. BELONGS TO THE UPRTASE FAMILY. Mb3337c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BN45,P0A659	No									X2BN45,P0A659	P0A659									
NC_002945.3	Mycobrowser_v4	CDS	3651723	3652622	.	+	0	Mb3338	sapm		acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase)	Mb3338, -, len: 299 aa. Equivalent to Rv3310, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 299 aa overlap). Possible acid phosphatase (EC 3.1.3.2), similar to several fungal or bacterial acid phosphatases e.g. BAB50846|MLR4110 from Rhizobium loti (Mesorhizobium loti) (292 aa), FASTA scores: opt: 460, E(): 4.8e-22, (38.65% identity in 295 aa overlap); P34724|PHOA_ASPNG from Aspergillus niger (417 aa), FASTA scores: opt: 172, E(): 0.0013, (29.1% identity in 306 aa overlap); P08540|PHOX_KLULA from Kluyveromyces lactis (Yeast) (421 aa), FASTA scores: opt: 170, E(): 0.0018, (27.8% identity in 266 aa overlap); P37274|PHOA_PENCH from Penicillium chrysogenum (412 aa),FASTA scores: opt: 163, E(): 0.0049, (29.05% identity in 303 aa overlap); etc.	Q7TWR9	No	cell wall and cell processes							IPR007312,IPR017850	Q7TWR9	A0A1R3Y3V0				Rv3310		Rv3310			
NC_002945.3	Mycobrowser_v4	CDS	3664237	3664770	.	-	0	Mb3353c	moaC3		PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 3 MOAC3	Mb3353c, moaC3, len: 177 aa. Equivalent to Rv3324c,len: 177 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 177 aa overlap). Probable moaC3,molybdopterin cofactor biosynthesis protein, highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa), FASTA scores: opt: 567, E(): 7.5e-30,(58.35% identity in 156 aa overlap); Q9RKA8|MOAC from Streptomyces coelicolor (170 aa), FASTA scores: opt: 553,E(): 6.3e-29, (58.25% identity in 158 aa overlap); P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa), FASTA scores: opt: 516, E(): 1.5e-26,(55.95% identity in 159 aa overlap); etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 734, E(): 1.3e-40, (71.8% identity in 163 aa overlap); and Rv0864|MOAC2|MTV043.57 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN (167 aa).	X2BNL6,P65393	No									X2BNL6,P65393	P65393									
NC_002945.3	Mycobrowser_v4	CDS	3656709	3657992	.	-	0	Mb3343c	deoA		PROBABLE THYMIDINE PHOSPHORYLASE DEOA (TDRPASE) (PYRIMIDINE PHOSPHORYLASE)	Mb3343c, deoA, len: 427 aa. Equivalent to Rv3314c,len: 427 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 427 aa overlap). Probable deoA,thymidine phosporylase (EC 2.4.2.4), highly similar to many e.g. Q9AK36|DEOA from Streptomyces coelicolor (427 aa), FASTA scores: opt: 1668, E(): 3.2e-90, (62.35% identity in 425 aa overlap); Q9CFM5|PDP from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (430 aa),FASTA scores: opt: 1031, E(): 5.5e-53, (46.45% identity in 392 aa overlap); P19971|TYPH_HUMAN|ECGF1 from Homo sapiens (Human) (482 aa), FASTA scores: opt: 957, E(): 1.3e-48,(44.45% identity in 441 aa overlap); P07650|TYPH_ECOLI|DEOA|TPP|TTG|B4382 from Escherichia coli strain K12 (440 aa), FASTA scores: opt: 847, E(): 3.2e-42,(41.55% identity in 438 aa overlap); etc. Contains PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. BELONGS TO THE THYMIDINE/PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASES FAMILY.	Q7TWR5	No								IPR000053,IPR000312,IPR013102,IPR017459,IPR017872,IPR018090	Q7TWR5	A0A1R3Y3S3									
NC_002945.3	Mycobrowser_v4	CDS	3657989	3658390	.	-	0	Mb3344c	cdd		PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE)	Mb3344c, cdd, len: 133 aa. Equivalent to Rv3315c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable cdd,cytidine deaminase (EC 3.5.4.5), equivalent to Q9CBD3|CDD|ML2174 CYTIDINE DEAMINASE from Mycobacterium leprae (134 aa), FASTA scores: opt: 516, E(): 5.8e-28,(56.8% identity in 132 aa overlap). Also highly similar to many e.g. Q9AK37|2SCK8.15 from Streptomyces coelicolor (130 aa), FASTA scores: opt: 523, E(): 1.9e-28, (60.0% identity in 130 aa overlap); Q9KD53|CDD|BH1366 from Bacillus halodurans (132 aa), FASTA scores: opt: 305, E(): 9.2e-14, (41.55% identity in 130 aa overlap); P56389|CDD_MOUSE|CDA|CDD from Mus musculus (Mouse) (146 aa), FASTA scores: opt: 287, E(): 1.6e-12, (40.3% identity in 124 aa overlap); P19079|CDD_BACSU (136 aa), FASTA scores: opt: 270, E(): 2.1e-11, (28.6% identity in 127 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. COFACTOR: ZINC (BY SIMILARITY).	Q7TWR4	No								IPR002125,IPR016193	Q7TWR4	A0A1R3Y3S6									
NC_002945.3	Mycobrowser_v4	CDS	3662596	3662838	.	-	0	Mb3350c	vapb44		possible antitoxin vapb44	Mb3350c, -, len: 80 aa. Equivalent to Rv3321c, len: 80 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 80 aa overlap). Conserved hypothetical protein, similar at N-terminal region to several proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. AAK48167|MT3800 DNA-BINDING PROTEIN (COPG FAMILY) from strain CDC1551 (74 aa), FASTA scores: opt: 142, E(): 0.0016, (48.85% identity in 43 aa overlap); AAK46916|MT2606 HYPOTHETICAL 8.0 KDA PROTEIN from strain CDC1551 (74 aa), FASTA scores: opt: 139, E(): 0.0026,(37.2% identity in 78 aa overlap); O50456|Rv1241|MTV006.13 HYPOTHETICAL 9.9 KDA PROTEIN from strain H37Rv (86 aa),FASTA scores: opt: 134, E(): 0.0066, (39.0% identity in 82 aa overlap); etc.	Q7TWQ8	No	virulence, detoxification, adaptation							IPR002145	Q7TWQ8	A0A1R3Y3U2				Rv3321c		Rv3321c			
NC_002945.3	Mycobrowser_v4	CDS	3658627	3658965	.	+	0	Mb3345	sdhC		PROBABLE SUCCINATE DEHYDROGENASE (CYTOCHROME B-556 SUBUNIT) SDHC (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)	Mb3345, sdhC, len: 112 aa. Equivalent to Rv3316,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Probable sdhC,cytochrome B-556 of succinate dehydrogenase SdhC subunit (EC 1.3.99.1), transmembrane protein, equivalent (but shorter 35 aa) to Q9CCM0|SDHC|ML0699 PUTATIVE SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT from Mycobacterium leprae (153 aa), FASTA scores: opt: 692, E(): 1.2e-39,(88.4% identity in 112 aa overlap). Also similar to others e.g. Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126 aa), FASTA scores: opt: 484, E(): 8.3e-26, (65.65% identity in 99 aa overlap); Q9RVR8|DR0954 from Deinococcus radiodurans (118 aa), FASTA scores: opt: 195, E(): 1.7e-06, (36.8% identity in 87 aa overlap); Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium sp. strain NRC-1 (130 aa), FASTA scores: opt: 192, E(): 2.9e-06, (37.85% identity in 74 aa overlap); P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis (Natronobacterium pharaonis) (130 aa), FASTA scores: opt: 183, E(): 1.1e-05, (35.15% identity in 74 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. BELONGS TO THE CYTOCHROME B560 FAMILY.	Q7TWR3	No	intermediary metabolism and respiration							IPR000701,IPR014314	Q7TWR3	A0A1R3Y3S5				Rv3316		Rv3316			
NC_002945.3	Mycobrowser_v4	CDS	3658962	3659396	.	+	0	Mb3346	sdhD		PROBABLE SUCCINATE DEHYDROGENASE (HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT) SDHD (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)	Mb3346, sdhD, len: 144 aa. Equivalent to Rv3317,len: 144 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 144 aa overlap). Probable sdhD,membrane anchor of succinate dehydrogenase SdhD subunit (EC 1.3.99.1), equivalent (but shorter 19 aa) to Q49915|SDHD|ML0698|L308_F1_25 PUTATIVE SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN from Mycobacterium leprae (163 aa), FASTA scores: opt: 878,E(): 1.9e-51, (85.2% identity in 142 aa overlap). Also similar to others e.g. Q9KZ89|SC5G8.25c from Streptomyces coelicolor (160 aa), FASTA scores: opt: 553, E(): 6.6e-30,(58.85% identity in 141 aa overlap); Q9RVR9|DR0953 from Deinococcus radiodurans (125 aa), FASTA scores: opt: 251,E(): 5.5e-10, (37.15% identity in 113 aa overlap); O29573|DHSD_ARCFU|SDHD|AF0684 from Archaeoglobus fulgidus (117 aa), FASTA scores: opt: 160, E(): 0.00056, (25.95% identity in 108 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN.	Q7TWR2	No	intermediary metabolism and respiration							IPR000701	Q7TWR2	A0A1R3Y5K3				Rv3317		Rv3317			
NC_002945.3	Mycobrowser_v4	CDS	3664767	3665141	.	-	0	Mb3354c	moaB3		PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB3 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD)	Mb3354c, moaB3, len: 124 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT3426, len: 124 aa, from Mycobacterium tuberculosis strain CDC1551, (100.000% identity in 124 aa overlap). Probable moaB3, pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), similar to others e.g. MOAB1|Rv3110|MT3193|MTCY164.20 PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis strain H37Rv (142 aa), FASTA scores: opt: 383, E(): 1.2e-21, (50.000% identity in 110 aa overlap); Q96YL0|STS230 PUTATIVE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Sulfolobus tokodaii (93 aa), FASTA scores: opt: 208, E(): 1.5e-08,(37.500% identity in 88 aa overlap); Q8YNL6|ASR4549 PTERIN-4A-CARBINOLAMINE DEHYDRATASE from Anabaena sp. strain PCC 7120 (93 aa), FASTA scores: opt: 179, E(): 2.2e-06, (37.363% identity in 91 aa overlap); P73790|PHS_SYNY3|SSL2296 PUTATIVE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Synechocystis sp. strain PCC 6803 (96 aa), FASTA scores: opt: 175, E(): 4.6e-06, (33.7% identity in 92 aa overlap); etc. BELONGS TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv.	Q7TTP5	No								IPR001533	Q7TTP5	A0A1R3Y3T7									
NC_002945.3	Mycobrowser_v4	CDS	3659525	3661297	.	+	0	Mb3347	sdhA		PROBABLE SUCCINATE DEHYDROGENASE (FLAVOPROTEIN SUBUNIT) SDHA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)	Mb3347, sdhA, len: 590 aa. Equivalent to Rv3318,len: 590 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 590 aa overlap). Probable sdhA,flavoprotein of succinate dehydrogenase SdhA subunit (EC 1.3.99.1), equivalent to Q9CCM1|SDHA|ML0697 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT from Mycobacterium leprae (584 aa), FASTA scores: opt: 3657, E(): 1.2e-217,(92.55% identity in 590 aa overlap). Also highly similar to others e.g. Q9KZ90|DHSA from Streptomyces coelicolor (584 aa), FASTA scores: opt: 2813, E(): 1.1e-165, (70.5% identity in 586 aa overlap); Q9RVS0|DR0952 from Deinococcus radiodurans (583 aa), FASTA scores: opt: 2203,E(): 4.1e-128, (57.35% identity in 593 aa overlap); P31038|DHSA_RICPR|SDHA|RP128 from Rickettsia prowazekii (596 aa), FASTA scores: opt: 1892, E(): 5.8e-109, (50.0% identity in 588 aa overlap); P10444|DHSA_ECOLI|SDHA|B0723|Z0877|ECS0748 from Escherichia coli strains K12 and O157:H7 (588 aa), FASTA scores: opt: 1844, E(): 5.2e-106, (48.75% identity in 591 aa overlap); etc. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. COFACTOR: FAD. SIMILAR TO THE FLAVOPROTEIN SUBUNITS OF OTHER SPECIES SUCCINATE DEHYDROGENASE AND OF FUMARATE REDUCTASE. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN.	Q7TWR1	No	intermediary metabolism and respiration							IPR003952,IPR003953,IPR011281,IPR014006,IPR015939,IPR027477	Q7TWR1	A0A1R3Y4I8				Rv3318		Rv3318			
NC_002945.3	Mycobrowser_v4	CDS	3661297	3662088	.	+	0	Mb3348	sdhB		PROBABLE SUCCINATE DEHYDROGENASE (IRON-SULPHUR PROTEIN SUBUNIT) SDHB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)	Mb3348, sdhB, len: 263 aa. Equivalent to Rv3319,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Probable sdhB,iron-sulphur protein succinate dehydrogenase SdhB subunit (EC 1.3.99.1), equivalent to Q49916|SDHB|ML0696|L308_F1_28 SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1678,E(): 4.7e-99, (89.8% identity in 264 aa overlap). Also highly similar to other e.g. Q9KZ91|DHSB from Streptomyces coelicolor (257 aa), FASTA scores: opt: 1125, E(): 4.6e-64, (64.1% identity in 262 aa overlap); Q9RVS1|DR0951 from Deinococcus radiodurans (264 aa), FASTA scores: opt: 1014, E(): 5e-57, (57.25% identity in 255 aa overlap); Q9PEF5|XF1073 from Xylella fastidiosa (261 aa), FASTA scores: opt: 681, E(): 5.8e-36, (45.1% identity in 244 aa overlap); P07014|DHSB_ECOLI|SDHB|B0724 from Escherichia coli strain K12 (238 aa), FASTA scores: opt: 657, E(): 1.8e-34, (43.75% identity in 240 aa overlap); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. COFACTOR: BINDS THREE DIFFERENT IRON-SULFUR CLUSTERS: A 2FE-2S, A 3FE-4S AND A 4FE-4S. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'PLANT-TYPE' 2FE-2S AND 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN,AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN.	Q7TWR0	No	intermediary metabolism and respiration							IPR001041,IPR004489,IPR009051,IPR012675,IPR017896,IPR017900,IPR025192	Q7TWR0	A0A1R3Y3V7				Rv3319		Rv3319			
NC_002945.3	Mycobrowser_v4	CDS	3666947	3668092	.	+	0	Mb3358	embR2		POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR2	Mb3358, embR2, len: 381 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT3428, len: 381 aa, from Mycobacterium tuberculosis strain CDC1551, (100.000% identity in 381 aa overlap). Possible embR2, transcriptional regulatory protein, highly similar to other mycobacteria EmbR proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15|EMBR PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR from Mycobacterium tuberculosis (388 aa), FASTA scores: opt: 1420, E(): 7.3e-84, (57.3% identity in 370 aa overlap); P71484|EMBR EMBR PROTEIN from Mycobacterium avium (384 aa) (see citation below), FASTA scores: opt: 1338, E(): 1.4e-78,(53.65% identity in 384 aa overlap); and also O05797|Rv3124|MT3208|MTCY164.34 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (311 aa), FASTA scores: opt: 928, E(): 3e-52, (53.75% identity in 255 aa overlap). Also similar to other transcriptional regulatory proteins from other organisms e.g. Q9XCC3|TYLT HYPOTHETICAL PATHWAY SPECIFIC REGULATORY PROTEIN from Streptomyces fradiae (404 aa), FASTA scores: opt: 506,E(): 5.7e-25, (38.153% identity in 249 aa overlap); etc. BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv.	Q7TWQ3	No								IPR000253,IPR001867,IPR005158,IPR008984,IPR011990,IPR011991,IPR016032	Q7TWQ3	A0A1R3Y3W7									
NC_002945.3	Mycobrowser_v4	CDS	3663571	3664236	.	-	0	Mb3352c	moaX		PROBABLE MOAD-MOAE FUSION PROTEIN MOAX	Mb3352c, moaX, len: 221 aa. Equivalent to Rv3323c,len: 221 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 221 aa overlap). Probable moaX,MoaD-MoaE fusion protein, similar (whole or partial) to several MoaD and MoaE proteins e.g. Q9RR88|DR2607 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D/E from Deinococcus radiodurans (229 aa), FASTA scores: opt: 407,E(): 1.8e-18, (32.75% identity in 223 aa overlap); Q9K8I7|MOAE|BH3019 MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus halodurans (156 aa), FASTA scores: opt: 375, E(): 1.3e-16, (41.65% identity in 132 aa overlap); O31705|MOAE MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus subtilis (157 aa), FASTA scores: opt: 368, E(): 3.6e-16, (41.65% identity in 132 aa overlap); etc. C-terminus highly similar to O05795|MOAE_MYCTU|Rv3119|MT3201|MTCY164.29|MOAE1 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 733, E(): 5.4e-39, (76.2% identity in 143 aa overlap); and N-terminus highly similar to O05789|MOAD1|Rv3112|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 333, E(): 3.2e-14, (65.05% identity in 83 aa overlap).	Q7TWQ6	No								IPR003448,IPR003749,IPR010034,IPR012675,IPR016155	Q7TWQ6	A0A1R3Y3S9									
NC_002945.3	Mycobrowser_v4	CDS	3665238	3666302	.	-	0	Mb3355c	moaA3		PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1	Mb3355c, moaA3, len: 354 aa. No equivalent in Mycobacterium tuberculosis strain H37Rv, but equivalent to MT3427|MOAA3, len: 378 aa, from Mycobacterium tuberculosis strain CDC1551, (100.000% identity in 354 aa overlap). Probable moaA3, molybdenum cofactor biosynthesis protein,similar to others e.g. O05786|MOA1_MYCTU|MOAA1|MOAA|Rv3109|MT3192|MTCY164.19 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Mycobacterium tuberculosis strain H37Rv (359 aa), FASTA scores: opt: 1762, E(): 3.7e-108, (74.3% identity in 350 aa overlap); Q99S04|MOAA|SA2063 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Staphylococcus aureus strain N315 (340 aa), FASTA scores: opt: 819, E(): 3.2e-46,(38.25% identity in 324 aa overlap); O67929|MOAA_AQUAE|AQ_2183 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A from Aquifex aeolicus (320 aa), FASTA scores: opt: 815, E(): 5.6e-46, (41.8% identity in 323 aa overlap); etc. BELONGS TO THE MOAA/NIFB/PQQE FAMILY. REMARK-M.bovis-M.tuberculosis: Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv.	X2BMW0,P62588	No									X2BMW0,P62588	P62588									
NC_002945.3	Mycobrowser_v4	CDS	3709479	3713138	.	-	0	Mb3383c	PPE56d		PPE FAMILY PROTEIN [THIRD PART]	Mb3383c, PPE56d, len: 1219 aa. Equivalent to 3' end of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 1219 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10,MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3670643	3671581	.	-	0	Mb3361c	sigJ		PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR (FRAGMENT) SIGJ	Mb3361c, sigJ, len: 312 aa. Equivalent to Rv3328c,len: 312 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 312 aa overlap). Probable sigJ,alternative RNA polymerase sigma factor (see citation below), highly similar to many e.g. Q9K3H7|2SCG18.10c from Streptomyces coelicolor (295 aa), FASTA scores: opt: 642,E(): 7.3e-31, (42.8% identity in 292 aa overlap); Q9A3D8|CC3266 from Caulobacter crescentus (291 aa), FASTA scores: opt: 607, E(): 8.4e-29, (39.8% identity in 294 aa overlap); Q9RD74|SCF43.14c from Streptomyces coelicolor (324 aa), FASTA scores: opt: 555, E(): 1.1e-25, (41.1% identity in 297 aa overlap); etc. Similar also to U00022_20 from Mycobacterium leprae; and MTCI28_22 and MSU87307_1. Also similar to O50445|SIGI|Rv1189|MTV005.25|MTCI364.01 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 426, E(): 4.2e-18, (32.65% identity in 294 aa overlap). Equivalent to AAK47774 from Mycobacterium tuberculosis strain CDC1551 (282 aa) but longer 30 aa. Contains probable helix-turn-helix motif at aa 129-150 (Score 1126, +3.02 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY.	Q7TWQ0	No								IPR007627,IPR009959,IPR011991,IPR013249,IPR013324,IPR013325,IPR014284	Q7TWQ0	A0A1R3Y3W3									
NC_002945.3	Mycobrowser_v4	CDS	3674339	3675847	.	+	0	Mb3364	sugI		PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN SUGI	Mb3364, sugI, len: 502 aa. Equivalent to Rv3331,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 502 aa overlap). Probable sugI,sugar-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to several transporters e.g. P37021|GALP_ECOLI|B2943 GALACTOSE-PROTON SYMPORTER (GALACTOSE TRANSPORTER) from Escherichia coli strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39,(31.85% identity in 446 aa overlap); P96742|YWTG METABOLITE-TRANSPORT-RELATED PROTEIN from Bacillus subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39,(33.2% identity in 428 aa overlap); AAG58074|GALP (alias BAB37242|ECS3819) GALACTOSE-PROTON SYMPORT OF TRANSPORT SYSTEM from Escherichia coli strain O157:H7 EDL933 (464 aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity in 432 aa overlap); P46333|CSBC_BACSU|SS92BR PROBABLE METABOLITE TRANSPORT PROTEIN from Bacillus subtilis (461 aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from Mycobacterium tuberculosis strain CDC1551 (500 aa) but with some divergence between residues 229 and 254. Contains PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2. BELONGS TO THE SUGAR TRANSPORTER FAMILY.	Q7TWP7	No	cell wall and cell processes							IPR003663,IPR005828,IPR005829,IPR016196,IPR020846	Q7TWP7	A0A1R3Y3V4				Rv3331		Rv3331			
NC_002945.3	Mycobrowser_v4	CDS	3713132	3719266	.	-	0	Mb3384c	PPE56b		PPE FAMILY PROTEIN [SECOND PART]	Mb3384c, PPE56b, len: 2044 aa. Equivalent to middle part of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 2018 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many M. tuberculosis proteins from strains H37Rv and CDC1551,e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1,MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3675844	3676995	.	+	0	Mb3365	nagA		PROBABLE N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE NAGA (GLCNAC 6-P DEACETYLASE)	Mb3365, nagA, len: 383 aa. Equivalent to Rv3332,len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 383 aa overlap). Probable nagA,N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25),similar to many e.g. Q9KXV7|SCD95A.17c PUTATIVE DEACETYLASE from Streptomyces coelicolor (381 aa), FASTA scores: opt: 1090, E(): 1.6e-55, (47.8% identity in 385 aa overlap); Q9PDB4|XF1465 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Xylella fastidiosa (386 aa), FASTA scores: opt: 667, E(): 3.5e-31, (38.3% identity in 394 aa overlap); Q9AAZ9|CC0443 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Caulobacter crescentus (378 aa), FASTA scores: opt: 661, E(): 7.5e-31, (38.9% identity in 383 aa overlap); O34450||NAGA_BACSU N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Bacillus subtilis (396 aa), FASTA scores: opt: 571, E(): 1.2e-25,(32.45% identity in 376 aa overlap); etc. Equivalent to AAK47778 from Mycobacterium tuberculosis strain CDC1551 (346 aa) but longer 37 aa. BELONGS TO THE NAGA FAMILY.	Q7TWP6	No	cell wall and cell processes							IPR003764,IPR006680,IPR011059	Q7TWP6	A0A1R3Y3W5				Rv3332		Rv3332			
NC_002945.3	Mycobrowser_v4	CDS	3724571	3724828	.	+	0	Mb3393	relk		toxin relk	Mb3393, -, len: 85 aa. Equivalent to Rv3358, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypohetical protein, highly similar to other hypohetical proteins e.g. Q9Z4V8|SCBAC17D6.03 from Streptomyces coelicolor (84 aa),FASTA scores: opt: 393, E(): 1.1e-21, (59.75% identity in 82 aa overlap); P56605|YOEB_ECOLI from Escherichia coli (84 aa), FASTA scores: opt: 305, E(): 2.2e-15, (49.35% identity in 77 aa overlap); Q9Z5W7 PUTATIVE DOC PROTEIN from Francisella novicida (68 aa), FASTA scores: opt: 253,E(): 9.6e-12, (51.6% identity in 62 aa overlap); BAB58569|SAV2407 from Staphylococcus aureus subsp. aureus Mu50 (88 aa), FASTA scores: opt: 250, E(): 2e-11, (40.5% identity in 84 aa overlap); etc.	X2BNR1,P64529	No	virulence, detoxification, adaptation								X2BNR1,P64529	P64529				Rv3358		Rv3358			
NC_002945.3	Mycobrowser_v4	CDS	3679870	3680880	.	-	0	Mb3369c	trpS		PROBABLE TRYPTOPHANYL-TRNA SYNTHETASE TRPS (TRYPTOPHAN--TRNA LIGASE) (TRPRS) (TRYPTOPHAN TRANSLASE)	Mb3369c, trpS, len: 336 aa. Equivalent to Rv3336c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable trpS,tryptophanyl-tRNA synthetase (EC 6.1.1.2), equivalent to Q49901|SYW_MYCLE|TRPS|ML0686|L308_C1_147 TRYPTOPHANYL-TRNA SYNTHETASE from Mycobacterium leprae (343 aa), FASTA scores: opt: 1859, E(): 4.8e-107, (83.75% identity in 339 aa overlap). Also similar to many e.g. Q9KZA7|TRPS2 from Streptomyces coelicolor (339 aa), FASTA scores: opt: 1359,E(): 2.6e-76, (60.3% identity in 335 aa overlap); Q9EYY6|TRPS from Klebsiella aerogenes (334 aa), FASTA scores: opt: 1077, E(): 5.5e-59, (52.15% identity in 328 aa overlap); P00954|SYW_ECOLI|TRPS|B3384 from Escherichia coli strain K12 (334 aa), FASTA scores: opt: 1074, E(): 8.3e-59, (51.85% identity in 328 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BP70,P67591	No									X2BP70,P67591	P67591									
NC_002945.3	Mycobrowser_v4	CDS	3681865	3683094	.	-	0	Mb3371c	icd1		PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP)	Mb3371c, icd1, len: 409 aa. Equivalent to Rv3339c,len: 409 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 409 aa overlap). Probable icd1,isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42),highly similar to many e.g. Q9A5C8|CC2522 from Caulobacter crescentus (403 aa), FASTA scores: opt: 1972, E(): 4.6e-115, (72.45% identity in 403 aa overlap); AAF73472|ICD from Rhizobium meliloti (404 aa), FASTA scores: opt: 1968, E(): 8.1e-115, (73.2% identity in 403 aa overlap); P50215|IDH_SPHYA from Sphingomonas yanoikuyae (406 aa), FASTA scores: opt: 1964, E(): 1.4e-114, (71.45% identity in 403 aa overlap); etc. Contains PS00470 Isocitrate and isopropylmalate dehydrogenases signature. BELONGS TO THE ISOCITRATE AND ISOPROPYLMALATE DEHYDROGENASES FAMILY.	X2BNC7,P65098	No									X2BNC7,P65098	P65098									
NC_002945.3	Mycobrowser_v4	CDS	3683377	3684726	.	+	0	Mb3372	metC		PROBABLE O-ACETYLHOMOSERINE SULFHYDRYLASE METC (HOMOCYSTEINE SYNTHASE) (O-ACETYLHOMOSERINE (THIOL)-LYASE) (OAH SULFHYDRYLASE) (O-ACETYL-L-HOMOSERINE SULFHYDRYLASE)	Mb3372, metC, len: 449 aa. Equivalent to Rv3340,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 449 aa overlap). Probable metC,O-acetyl-L-homoserine sulfhydrylase (EC 4.2.99.10), highly similar to many e.g. Q9K9P2|BH2603 O-ACETYLHOMOSERINE SULFHYDRYLASE from Bacillus halodurans (430 aa), FASTA scores: opt: 1716, E(): 3.3e-97, (60.45% identity in 425 aa overlap); Q9HUE4|METY|PA5025 HOMOCYSTEINE SYNTHASE from Pseudomonas aeruginosa (425 aa), FASTA scores: opt: 1517,E(): 4.4e-85, (56.95% identity in 425 aa overlap); Q9WZY4|TM0882 O-ACETYLHOMOSERINE SULFHYDRYLASE from Thermotoga maritima (430 aa), FASTA scores: opt: 1488,E(): 2.6e-83, (55.75% identity in 418 aa overlap); BAB54344|MLR8465 O-ACETYLHOMOSERINE SULFHYDRYLASE from Rhizobium loti (Mesorhizobium loti) (426 aa), FASTA scores: opt: 1445, E(): 1.1e-80, (53.2% identity in 419 aa overlap); P50125|CYSD_EMENI O-ACETYLHOMOSERINE (THIOL)-LYASE from Emericella nidulans (Aspergillus nidulans) (437 aa), FASTA scores: opt: 1442, E(): 1.7e-80,(53.7% identity in 430 aa overlap); etc. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. COFACTOR: PYRIDOXAL PHOSPHATE. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY.	Q7TWP1	No	intermediary metabolism and respiration							IPR015422,IPR000277,IPR006235,IPR015421,IPR015424	Q7TWP1	A0A1R3Y3W1				Rv3340		Rv3340			
NC_002945.3	Mycobrowser_v4	CDS	3684738	3685877	.	+	0	Mb3373	metA		PROBABLE HOMOSERINE O-ACETYLTRANSFERASE META (HOMOSERINE O-TRANS-ACETYLASE) (HOMOSERINE TRANSACETYLASE) (HTA)	Mb3373, metA, len: 379 aa. Equivalent to Rv3341,len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 379 aa overlap). Probable metA,homoserine o-acetyltransferase (EC 2.3.1.31), equivalent to O32874|METX_MYCLE|META|ML0682|MLCB1779.11 HOMOSERINE O-ACETYLTRANSFERASE from Mycobacterium leprae (382 aa),FASTA scores: opt: 2263, E(): 9.2e-129, (85.0% identity in 380 aa overlap). Also highly similar to many e.g. O68640|METX_CORGL|META from Corynebacterium glutamicum (Brevibacterium flavum) (379 aa), FASTA scores: opt: 1135,E(): 5.9e-61, (48.5% identity in 371 aa overlap); Q9AAS1|CC0525 from Caulobacter crescentus (382 aa), FASTA scores: opt: 860, E(): 2e-44, (40.5% identity in 363 aa overlap); P94891|METX_LEPME from Leptospira meyeri (379 aa), FASTA scores: opt: 787, E(): 4.9e-40, (38.2% identity in 385 aa overlap); etc. BELONGS TO THE AB HYDROLASE FAMILY, HTA SUBFAMILY.	X2BNP0,P0A5J9	No	intermediary metabolism and respiration								X2BNP0,P0A5J9	P0A5J9				Rv3341		Rv3341			
NC_002945.3	Mycobrowser_v4	CDS	3700427	3706717	.	-	0	Mb3380c	PPE55a		PPE FAMILY PROTEIN [FIRST PART]	Mb3380c, PPE55a, len: 2096 aa. Similar to 5' end of Rv3347c, len: 3157 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 2044 aa overlap). Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-,Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16,MTCY63_9, MTY13E10_17, MTCY180_1; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b.	Q7TWN7	No								IPR000030,IPR002989	Q7TWN7	A0A1R3Y3Y7									
NC_002945.3	Mycobrowser_v4	CDS	3690679	3694692	.	-	0	Mb3376c	PE_PGRS50b		pe-pgrs family protein pe_pgrs49	Mb3376c, PE_PGRS50b, len: 1337 aa. Equivalent to middle part of Rv3345c (PE_PGRS50) and Rv3344c (PE_PGRS49), len: 1538 aa and 484 aa, from Mycobacterium tuberculosis strain H37Rv, (81.45% identity in 992 aa overlap and 100.000% identity in 477 aa overlap). Rv3345c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21, MTV023_15, MTCY493_4,MTV039_16, MTV008_46, MTV023_14, MTV023_19, MTV043_26,MTCY493_2, MTCY441_4; etc. Rv3344c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins. Appears to be a gene fragment,should be in-frame with following ORF, MTV016.45c,frameshift required around 49595 but could not be found on checking BAC and cosmid clones. Similar to many from M. tuberculosis strains H37Rv and CDC1551 e.g. O53557|Rv3512|MTV023.19 (1079 aa), FASTA scores: opt: 1595, E(): 1.8e-54, (52.0% identity in 544 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b. Also in Mycobacterium tuberculosis strain H37Rv, PE_PGRS49 and PE_PGRS50 exist as 2 genes. In Mycobacterium bovis, a single base deletion (c-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3694689	3696308	.	-	0	Mb3377c	PE_PGRS50a		PE-PGRS FAMILY PROTEIN [FIRST PART]	Mb3377c, PE_PGRS50a, len: 539 aa. Equivalent to 5' end of Rv3345c, len: 1538 aa, from Mycobacterium tuberculosis strain H37Rv, (88.25% identity in 315 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21,MTV023_15, MTCY493_4, MTV039_16, MTV008_46, MTV023_14,MTV023_19, MTV043_26, MTCY493_2, MTCY441_4; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b.	Q7TWN9	No								IPR000084	Q7TWN9	A0A1R3Y4L8									
NC_002945.3	Mycobrowser_v4	CDS	3697245	3700430	.	-	0	Mb3379c	PPE55b		PPE FAMILY PROTEIN [SECOND PART]	Mb3379c, PPE55b, len: 1061 aa. Equivalent to 3' end of Rv3347c, len: 3157 aa, from Mycobacterium tuberculosis strain H37Rv, (99.812% identity in 1061 aa overlap). Member of the Mycobacterium tuberculosis PPE family, Gly-,Ala-, Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16,MTCY63_9, MTY13E10_17, MTCY180_1; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3719324	3720628	.	-	0	Mb3385c	PPE56a		PPE FAMILY PROTEIN [FIRST PART]	Mb3385c, PPE56a, len: 434 aa. Equivalent to 5' end of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 434 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-,Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1,MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d.	Q7TWN6	No								IPR000030,IPR002989	Q7TWN6	A0A1R3Y3Y6									
NC_002945.3	Mycobrowser_v4	CDS	3723330	3724175	.	-	0	Mb3391c	folD		PROBABLE BIFUNCTIONAL PROTEIN FOLD: METHYLENETETRAHYDROFOLATE DEHYDROGENASE + METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE	Mb3391c, folD, len: 281 aa. Equivalent to Rv3356c,len: 281 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 281 aa overlap). Probable folD,bifunctional enzyme include methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9), equivalent to O32879|FOLD|ML0674 METHYLENETETRAHYDROFOLATE DEHYDROGENASE (PUTATIVE METHYLENETETRAHYDROFOLATE DEHYDROGENASE/METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE) from Mycobacterium leprae (282 aa), FASTA scores: opt: 1624, E(): 1.2e-93, (86.45% identity in 281 aa overlap). Also similar to many others e.g. Q9K3J6|FOLD from Streptomyces coelicolor (284 aa), FASTA scores: opt: 1223,E(): 9.5e-69, (66.65% identity in 279 aa overlap); Q9K966|FOLD from Bacillus halodurans (279 aa), FASTA scores: opt: 886, E(): 7.7e-48, (47.15% identity in 280 aa overlap); P54382|FOLD_BACSU from Bacillus subtilis (283 aa), FASTA scores: opt: 820, E(): 9.7e-44, (45.7% identity in 280 aa overlap); P51696|FOLD_PHOPO from Photobacterium phosphoreum (285 aa), FASTA scores: opt: 778, E(): 4e-41,(44.9% identity in 283 aa overlap); P24186|FOLD_ECOLI|ADS|B0529 from Escherichia coli (287 aa), FASTA scores: opt: 741, E(): 0,44.4, (44.4% identity in 277 aa overlap); etc. Also highly similar to MLCB1779_9 from Mycobacterium leprae cosmid B1779 (282 aa) (86.5% identity in 281 aa overlap). SIMILAR TO OTHER DEHYDROGENASE/CYCLOHYDROLASE ENZYMES OR DOMAINS.	X2BNF5,Q7TWN0	No									X2BNF5,Q7TWN0	Q7TWN0									
NC_002945.3	Mycobrowser_v4	CDS	3724299	3724574	.	+	0	Mb3392	relj		antitoxin relj	Mb3392, -, len: 91 aa. Equivalent to Rv3357, len: 91 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 91 aa overlap). Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9Z4V7|YU1E_STRCO (alias CAC37261|SCBAC17D6.02) ORFU1E (BELONGS TO THE PHD/YEFM FAMILY) from Streptomyces coelicolor (87 aa), FASTA scores: opt: 344, E(): 1.9e-17,(62.05% identity in 87 aa overlap); P46147|YEFM_ECOLI|B2017 from Escherichia coli strain K12 (83 aa), FASTA scores: opt: 215, E(): 1.6e-08, (50.0% identity in 72 aa overlap); BAB58570|SAV2408 from Staphylococcus aureus subsp. aureus Mu50 (83 aa), FASTA scores: opt: 161, E(): 8.8e-05, (39.95% identity in 77 aa overlap); Q9Z5W8 PUTATIVE PHD PROTEIN from Francisella novicid (85 aa), FASTA scores: opt: 143, E(): 0.0016,(28.9% identity in 83 aa overlap); etc. Also similar to Rv1247c|MTV006.19c (89 aa) (36.9% identity in 84 aa overlap). SEEMS TO BELONG TO THE PHD/YEFM FAMILY.	X2BN90	No	virulence, detoxification, adaptation								X2BN90	P65068				Rv3357		Rv3357			
NC_002945.3	Mycobrowser_v4	CDS	3731263	3731727	.	+	0	Mb3401	spoU		PROBABLE tRNA/rRNA METHYLASE SPOU (tRNA/rRNA METHYLTRANSFERASE)	Mb3401, spoU, len: 154 aa. Equivalent to Rv3366,len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 154 aa overlap). Probable spoU,tRNA/rRNA methylase (EC 2.1.1.-), equivalent to Q9CCU7|ML0419 PUTATIVE tRNA/rRNA METHYLTRANSFERASE from Mycobacterium leprae (158 aa), FASTA scores: opt: 861,E(): 1.2e-50, (83.75% identity in 154 aa overlap); and O07698|MLCL383.24c rRNA METHYLASE from Mycobacterium leprae (169 aa), FASTA scores: opt: 861, E(): 1.3e-50,(83.75% identity in 154 aa overlap). Also highly similar to many members of the spoU family of rRNA methylases e.g. Q9K199|NMB0268 RNA METHYLTRANSFERASE (TRMH FAMILY) from Neisseria meningitidis (serogroup B) (154 aa), FASTA scores: opt: 534, E(): 7.6e-29, (50.0% identity in 154 aa overlap); and Q9JSM8|NMA2218 from Neisseria meningitidis (serogroup A) (154 aa), FASTA scores: opt: 526, E(): 2.6e-28, (49.35% identity in 154 aa overlap); Q9HU57|PA5127 from Pseudomonas aeruginosa (153 aa), FASTA scores: opt: 531, E(): 1.2e-28, (52.95% identity in 151 aa overlap); P33899|YIBK_ECOLI|B3606 from Escherichia coli strain K12 (157 aa), FASTA scores: opt: 511, E(): 2.6e-27,(49.35% identity in 154 aa overlap); etc. BELONGS TO THE RNA METHYLTRANSFERASE TRMH FAMILY.	Q7TWM3	No	information pathways							IPR001537,IPR016914	Q7TWM3	A0A1R3Y407				Rv3366		Rv3366			
NC_002945.3	Mycobrowser_v4	CDS	3779176	3779586	.	+	0	Mb3442	vapc47		possible toxin vapc47. contains pin domain.	Mb3442, -, len: 136 aa. Equivalent to Rv3408, len: 136 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 136 aa overlap). Hypothetical protein,similar to other hypothetical proteins from M. tuberculosis strains H37Rv and CDC1551 e.g. O50411|Rv3384c|MTV004.42c (130 aa), FASTA scores: opt: 243, E(): 1.7e-09, (35.1% identity in 131 aa overlap); P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: 191, E(): 5e-06, (35.5% identity in 138 aa overlap), etc.	Q7TWJ5	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TWJ5	A0A1R3Y440				Rv3408		Rv3408			
NC_002945.3	Mycobrowser_v4	CDS	3732094	3733974	.	+	0	Mb3402	PE_PGRS51		pe-pgrs family protein pe_pgrs51	Mb3402, PE_PGRS51, len: 626 aa. Similar to Rv3367,len: 588 aa, from Mycobacterium tuberculosis strain H37Rv,(93.75% identity in 626 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50415|Rv3388|MTV004.46 (731 aa), FASTA scores: opt: 1999,E(): 7.2e-72, (55.0% identity in 620 aa overlap); and MTV004_44, MTV043_65, MTV006_15, MTCY63_2, MTCY21B4_13,MTV023_21, MTV008_43, MTCY24A1_4, MTV023_15; etc. Equivalent to AAK47814 from M. tuberculosis strain CDC1551 (628 aa) but shorter 37 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-ggcagcggt) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa).	Q7TWM2	No								IPR000084	Q7TWM2	A0A1R3Y3Z3									
NC_002945.3	Mycobrowser_v4	CDS	3833769	3834779	.	-	0	Mb3498c	mhpE		PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE MHPE (HOA)	Mb3498c, mhpE, len: 336 aa. Equivalent to Rv3469c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable mhpE,4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), similar to others (principally from Pseudomonas species) e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338 aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65% identity in 332 aa overlap); Q9X9Q0|NIKB NIKB PROTEIN (see first citation below) from Streptomyces tendae (357 aa),FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in 339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp. strain KKS102 (352 aa), FASTA scores: opt: 549, E(): 9.9e-27, (31.2% identity in 314 aa overlap); Q51983|CMTG_PSEPU from Pseudomonas putida (350 aa), FASTA scores: opt: 543, E(): 2.3e-26, (30.7% identity in 319 aa overlap); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 517, E(): 9.1e-25, (31.75% identity in 312 aa overlap); etc. Also similar to P71867|MTCY03C7.22|Rv3534c HYPOTHETICAL 36.4 KDA PROTEIN from Mycobacterium tuberculosis (346 aa),FASTA scores: E(): 7.5e-24, (31.9% identity in 310 aa overlap).	Q7TWG2	No								IPR000891,IPR013785,IPR017629	Q7TWG2	A0A1R3Y4Y7									
NC_002945.3	Mycobrowser_v4	CDS	3735141	3738380	.	-	0	Mb3405c	dnaE2		PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE2 (DNA NUCLEOTIDYLTRANSFERASE)	Mb3405c, dnaE2, len: 1079 aa. Equivalent to Rv3370c, len: 1079 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1079 aa overlap). Probable dnaE2, DNA polymerase III, alpha chain (EC 2.7.7.7), similar to many e.g. BAB51086|MLR4428 from Rhizobium loti (Mesorhizobium loti) (1118 aa), FASTA scores: opt: 1103, E(): 8.9e-59, (37.65% identity in 1075 aa overlap); Q9S291|SCI11.28c from Streptomyces coelicolor (1185 aa), FASTA scores: opt: 937, E(): 1e-48, (33.4% identity in 1090 aa overlap); O67125|DP3A_AQUAE|DNAE|AQ_1008 from Aquifex aeolicus (1161 aa), FASTA scores: opt: 895, E(): 3.4e-46, (29.9% identity in 1071 aa overlap); O51526|DP3A_BORBU from Borrelia burgdorferi (Lyme disease spirochete) (1147 aa), FASTA scores: opt: 835, E(): 1.4e-42, (30.05% identity in 888 aa overlap); etc. Equivalent to AAK47817 from Mycobacterium tuberculosis strain CDC1551 (1098 aa) but shorter 19 aa. Also similar to Mycobacterium tuberculosis DP3A_MYCTU|MTCY48.18c (29.6% identity in 1110 aa overlap). BELONGS TO DNA POLYMERASE TYPE-C FAMILY, DNAE SUBFAMILY.	X2BN20,Q7TWL9	No	information pathways								X2BN20,Q7TWL9	Q7TWL9				Rv3370c		Rv3370c			
NC_002945.3	Mycobrowser_v4	CDS	3739954	3741129	.	+	0	Mb3407	otsB2		trehalose 6-phosphate phosphatase otsb2 (trehalose-phosphatase) (tpp)	Mb3407, otsB2, len: 391 aa. Equivalent to Rv3372,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 391 aa overlap). Possible otsB2,trehalose-6-phosphate phosphatase (EC 3.1.3.12),equivalent to Q49734|OTSB2|OTSP|B1620_F1_1|MLCL383.17c PUTATIVE TREHALOSE-PHOSPHATASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 1675, E(): 2.4e-91, (67.05% identity in 425 aa overlap). Also weakly similar to several trehalose phosphatases e.g. Q9C8B3|F10O5.8 from Arabidopsis thaliana (Mouse-ear cress) (366 aa), FASTA scores: opt: 432, E(): 3.1e-18, (36.65% identity in 281 aa overlap); O27788|MTH1760 from Methanobacterium thermoautotrophicum (264 aa), FASTA scores: opt: 347, E(): 2.5e-13, (30.75% identity in 221 aa overlap); Q9FWQ2 from Oryza sativa (Rice) (382 aa), FASTA scores: opt: 338, E(): 1.1e-12, (32.5% identity in 320 aa overlap); etc. Also similar to part of Mycobacterium tuberculosis Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),FASTA scores: opt: 1192, E(): 1.6e-62, (56.65% identity in 339 aa overlap).	X2BNA0,Q7TWL7	No									X2BNA0,Q7TWL7	Q7TWL7									
NC_002945.3	Mycobrowser_v4	CDS	3742261	3743688	.	+	0	Mb3409	amiD		PROBABLE AMIDASE AMID (ACYLAMIDASE) (ACYLASE)	Mb3409, amiD, len: 475 aa. Equivalent to Rv3375,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 475 aa overlap). Probable amiD,amidase (EC 3.5.1.4), similar to various amidases e.g. Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from Rhodococcus sp. (462 aa), FASTA scores: opt: 1036, E(): 1.6e-54, (38.6% identity in 464 aa overlap); Q9ZHK8|PZAA NICOTINAMIDASE/PYRAZINAMIDASE from Mycobacterium smegmatis (468 aa), FASTA scores: opt: 930, E(): 3.4e-48, (36.3% identity in 463 aa overlap); Q9A551|CC2613 PYRAZINAMIDASE/NICOTINAMIDASE from Caulobacter crescentus (464 aa), FASTA scores: opt: 841, E(): 7.1e-43, (39.45% identity in 469 aa overlap); O69768|AMID_PSEPU AMIDASE from Pseudomonas putida (466 aa), FASTA scores: opt: 800,E(): 2e-40, (33.6% identity in 467 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from Archaeoglobus fulgidu (453 aa), FASTA scores: opt: 669,E(): 1.3e-32, (30.4% identity in 467 aa overlap); etc. Also some similarity to AMIB2|Rv1263|MT1301|MTCY50.19c putative amidase from Mycobacterium tuberculosis (462 aa),(31.5% identity in 466 aa overlap). SEEMS BELONG TO THE AMIDASE FAMILY.	X2BPC8,P63497	No	intermediary metabolism and respiration								X2BPC8,P63497	P63497				Rv3375		Rv3375			
NC_002945.3	Mycobrowser_v4	CDS	3746896	3748506	.	-	0	Mb3413c	dxs2		PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS2 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS)	Mb3413c, dxs2, len: 536 aa. Equivalent to Rv3379c,len: 536 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 536 aa overlap). Probable dxs2,1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-),similar to many e.g. Q9F1V2|DXS from Kitasatospora griseola (Streptomyces griseolosporeus) (649 aa), FASTA scores: opt: 1274, E(): 5.4e-71, (50.9% identity in 570 aa overlap); Q9X7W3|DXS_STRCO|SC6A5.17 from Streptomyces coelicolor (656 aa), FASTA scores: opt: 1248, E(): 2.2e-69, (50.55% identity in 568 aa overlap); Q9RBN6|DXS_STRC1 from Streptomyces sp. strain CL190 (631 aa), FASTA scores: opt: 1237, E(): 1e-68, (49.1% identity in 570 aa overlap); Q50000|DXS_MYCLE|TKTB|ML1038 from M. leprae (643 aa), FASTA scores: opt: 1215, E(): 2.4e-67,(46.75% identity in 571 aa overlap); Q9R6S7|DXS_SYNLE from Synechococcus leopoliensis (636 aa), FASTA scores: opt: 849, E(): 8.9e-45, (38.55% identity in 550 aa overlap); etc. Also similar to O07184|DXS_MYCTU|Rv2682c|MT2756|MTCY05A6.03c from M. tuberculosis (638 aa), FASTA scores: opt: 1226, E(): 4.9e-68, (48.9% identity in 558 aa overlap). BELONGS TO THE TRANSKETOLASE FAMILY, DXS SUBFAMILY. COFACTOR: THIAMINE PYROPHOSPHATE (BY SIMILARITY). Note that the N-terminus of this putative protein appears to have been interrupted by the adjacent IS6110 element.	Q7TWL2	No								IPR005475,IPR005476,IPR005477,IPR009014,IPR020826	Q7TWL2	A0A1R3Y414									
NC_002945.3	Mycobrowser_v4	CDS	3748731	3749720	.	-	0	Mb3414c	lytB1		PROBABLE LYTB-RELATED PROTEIN LYTB1	Mb3414c, lytB1, len: 329 aa. Equivalent to Rv3382c,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 329 aa overlap). Probable lytB1,lytB-related protein, highly similar to many e.g. Q9HVM7|LYTB_PSEAE|PA4557 from Pseudomonas aeruginosa (314 aa), FASTA scores: opt: 1048, E(): 2e-55, (53.2% identity in 314 aa overlap); Q9JR39|LYTB|NMA0624|NMB1831 from Neisseria meningitidis (serogroup A and B) (322 aa), FASTA scores: opt: 1041, E(): 5.4e-55, (52.25% identity in 312 aa overlap); P22565|LYTB_ECOLI|B0029 from Escherichia coli strain K12 (316 aa), FASTA scores: opt: 1013, E(): 2.5e-53, (51.45% identity in 311 aa overlap) (for more information about lytB protein, see citation below); Q9X781|LYTB_MYCLE|LYTB2|ML1938|MLCB1222.06c from Mycobacterium leprae (332 aa), FASTA scores: opt: 979,E(): 2.8e-51, (51.3% identity in 312 aa overlap); etc. Also similar to Q9PAS9|XF2416 DRUG TOLERANCE PROTEIN from Xylella fastidiosa (316 aa), FASTA scores: opt: 1043, E(): 4.1e-55, (53.65% identity in 315 aa overlap). And similar to O53458|Rv1110|LYTB2|MTV017.63 from Mycobacterium tuberculosis (335 aa), FASTA scores: opt: 975, E(): 4.9e-51, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY.	X2BPD5,P0A5I3	No									X2BPD5,P0A5I3	P0A5I3									
NC_002945.3	Mycobrowser_v4	CDS	3749720	3750772	.	-	0	Mb3415c	idsB		POSSIBLE POLYPRENYL SYNTHETASE IDSB (POLYPRENYL TRANSFERASE) (POLYPRENYL DIPHOSPHATE SYNTHASE)	Mb3415c, idsB, len: 350 aa. Equivalent to Rv3383c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 350 aa overlap). Possible idsB,polyprenyl transferase (polyprenyl diphosphate synthase) (EC 2.5.1.-), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR GERANYL TRANSFERASE from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908, E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS GERANYL GERANYL DIPHOSPHATE SYNTHASE from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 PUTATIVE POLYPRENYL SYNTHETASE from Streptomyces coelicolor (378 aa), FASTA scores: opt: 779, E(): 5.3e-42, (44.45% identity in 324 aa overlap); Q9S5E9 FARNESYL, GERANYLGERANYL,GERANYLFARNESYL, HEXAPRENYL, HEPTAPRENYL DIPHOSPHATE SYNTHASE (SELF-HEPPS) from Synechococcus elongatus (324 aa), FASTA scores: opt: 563, E(): 2.3e-28, (39.85% identity in 241 aa overlap) (see citation below); O26156|IDSA_METTH|MTH50 BIFUNCTIONAL SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE [INCLUDES: FARNESYL PYROPHOSPHATE SYNTHETASE (EC 2.5.1.1) (FPP SYNTHETASE) (DIMETHYLALLYLTRANSFERASE) AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10)] from Methanobacterium thermoautotrophicum (325 aa), FASTA scores: opt: 540, E(): 6.5e-27, (35.75% identity in 319 aa overlap); P95999|GGPP_SULSO|GDS|GDS-1|SSO0061|C05010|C05_049 GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (GGPP SYNTHETASE) (GGPS) [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1)AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10) AND FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Sulfolobus solfataricus (332 aa), FASTA scores: opt: 511, E(): 4.5e-25 (36.9% identity in 244 aa overlap); etc. Also similar to Q50727|GGPP_MYCTU|Rv3398c|MT3506|MTCY78.30 PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1); GERANYLTRANSTRANSFERASE (EC 2.5.1.10); FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 687, E(): 3.4e-36, (39.1% identity in 325 aa overlap). Contains PS00723 Polyprenyl synthetases signature 1. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY.	Q7TWL1	No								IPR000092,IPR008949,IPR017446	Q7TWL1	A0A1R3Y421									
NC_002945.3	Mycobrowser_v4	CDS	3751526	3751918	.	-	0	Mb3416c	vapc46		possible toxin vapc46. contains pin domain.	Mb3416c, -, len: 130 aa. Equivalent to Rv3384c,len: 130 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 130 aa overlap). Hypothetical protein,similar to Mycobacterium tuberculosis hypothetical proteins P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: 266, E(): 1.6e-10, (43.1% identity in 130 aa overlap); and Q50717|YY08_MYCTU|Rv3408|MTCY78.20c (136 aa), FASTA scores: opt: 243, E(): 4.8e-09, (35.1% identity in 131 aa overlap).	Q7TWL0	No	virulence, detoxification, adaptation							IPR002716,IPR022907	Q7TWL0	A0A1R3Y5Q5				Rv3384c		Rv3384c			
NC_002945.3	Mycobrowser_v4	CDS	3751918	3752226	.	-	0	Mb3417c	vapb46		possible antitoxin vapb46	Mb3417c, -, len: 102 aa. Equivalent to Rv3385c,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). Hypothetical protein,similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 (99 aa), FASTA scores: opt: 155, E(): 0.001, (41.05% identity in 78 aa overlap); O07782|Rv0596c|MTCY19H5.26 (85 aa), FASTA scores: opt: 136, E(): 0.016, (39.45% identity in 71 aa overlap); P96916|Rv0626|MTCY20H10.07 (86 aa),FASTA scores: opt: 130, E(): 0.04, (51.2% identity in 41 aa overlap); etc. Also similar to PREVENT HOST DEATH (PHD) PROTEINS e.g. CAA66834|PHD from Escherichia coli (73 aa),FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap); and Q06253|PHD_BPP1 from Bacteriophage P1 (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap).	Q7TWK9	No	virulence, detoxification, adaptation							IPR006442	Q7TWK9	A0A1R3Y4Q5				Rv3385c		Rv3385c			
NC_002945.3	Mycobrowser_v4	CDS	3753936	3756185	.	+	0	Mb3420	PE_PGRS52		pe-pgrs family protein pe_pgrs52	Mb3420, PE_PGRS52, len: 749 aa. Similar to Rv3388,len: 731 aa, from Mycobacterium tuberculosis strain H37Rv,(94.8% identity in 734 aa overlap). Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many PE-family proteins from M. tuberculosis strains H37Rv and CDC1551 e.g. O53553|YZ08_MYCTU|RV3508|MTV023.15 (1901 aa), FASTA scores: opt: 2380, E(): 3.6e-87, (53.8% identity in 773 aa overlap); and MTV023_21, MTV023_18, MTV023_14, MTV039_16,MTCY441_4. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (cggcggcgc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (749 aa versus 731 aa).	Q7TWK6	No								IPR000084	Q7TWK6	A0A1R3Y432									
NC_002945.3	Mycobrowser_v4	CDS	3760798	3761724	.	+	0	Mb3425	iunH		PROBABLE NUCLEOSIDE HYDROLASE IUNH (PURINE NUCLEOSIDASE)	Mb3425, iunH, len: 308 aa. Equivalent to Rv3393,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable iunH,nucleoside hydrolase (EC 3.2.2.-), similar to others e.g. Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA scores: opt: 497, E(): 6e-24, (34.3% identity in 312 aa overlap); Q27546|IUNH_CRIFA from Crithidia fasciculata (314 aa), FASTA scores: opt: 475, E(): 1.4e-22, (31.45% identity in 318 aa overlap); Q9CK67|IUNH from Pasteurella multocida (310 aa), FASTA scores: opt: 464, E(): 6.9e-22,(30.9% identity in 314 aa overlap); Q9A549|CC2615 from Caulobacter crescentus (323 aa), FASTA scores: opt: 464,E(): 7.2e-22, (37.85% identity in 280 aa overlap); etc. Note that also similar to BAB34113|ECS0690 (alias AAG54985|YBEK) PUTATIVE TRNA SYNTHETASE from Escherichia coli strain O157:H7 (311 aa), FASTA scores: opt: 483, E(): 4.5e-23, (33.0% identity in 315 aa overlap). The active site histidine is conserved.	Q7TWK1	No	intermediary metabolism and respiration							IPR001910,IPR023186	Q7TWK1	A0A1R3Y430				Rv3393		Rv3393			
NC_002945.3	Mycobrowser_v4	CDS	3756256	3757128	.	-	0	Mb3421c	htdy		probable 3-hydroxyacyl-thioester dehydratase htdy	Mb3421c, -, len: 290 aa. Equivalent to Rv3389c,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 290 aa overlap). Possible dehydrogenase (EC 1.-.-.-), similar to parts of several bacterial dehydrogenases and eukaryotic short-chain dehydrogenases involved in steroid biosynthesis e.g. Q9UVH9|FOX2 FOX2 PROTEIN (a multifunctional protein of the peroxisomal beta-oxidation) (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Glomus mosseae (1015 aa), FASTA scores: opt: 649, E(): 7.5e-33,(40.9% identity in 269 aa overlap); Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 602, E(): 2.7e-30, (40.35% identity in 305 aa overlap); AAH03098 HYDROXYSTEROID (17-BETA) DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); P51659|DHB4_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); Q19058|E04F6.3 HYDRATASE-DEHYDROGENASE-EPIMERASE from Caenorhabditis elegans (298 aa), FASTA scores: opt: 573, E(): 1.6e-28,(41.0% identity in 266 aa overlap); O42484 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE IV from Gallus gallus (Chicken) (735 aa), FASTA scores: opt: 573, E(): 3.2e-28, (39.8% identity in 279 aa overlap); etc. And also similar in part to Q9LBK1|PHAJ2|PA1018 (R)-SPECIFIC ENOYL-COA HYDRATASE from Pseudomonas aeruginosa (288 aa),FASTA scores: opt: 601, E(): 2.7e-30, (40.5% identity in 294 aa overlap). And similar to P71863|UFAA2|Rv3538|MTCY03C7.18c HYPOTHETICAL 30.2 KDA PROTEIN from Mycobacterium tuberculosis (286 aa), FASTA scores: opt: 609, E(): 8.7e-31, (39.65% identity in 285 aa overlap). HAS SOME SIMILARITY TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	Q7TWK5	No	intermediary metabolism and respiration							IPR002539	Q7TWK5	A0A1R3Y429				Rv3389c		Rv3389c			
NC_002945.3	Mycobrowser_v4	CDS	3757202	3757912	.	+	0	Mb3422	lpqD		PROBABLE CONSERVED LIPOPROTEIN LPQD	Mb3422, lpqD, len: 236 aa. Equivalent to Rv3390,len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 236 aa overlap). Probable lpqD, a conserved lipoprotein with some similarity to various bacterial proteins e.g. Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa), FASTA scores: opt: 416, E(): 2.5e-18, (33.0% identity in 197 aa overlap); Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 314, E(): 3.7e-12, (28.55% identity in 203 aa overlap); P73454|SLR1748 HYPOTHETICAL 24.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (214 aa), FASTA scores: opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. O53817|Rv0754|MTV041.28 PGRS-FAMILY PROTEIN (584 aa), FASTA scores: opt: 219, E(): 5.1e-06, (39.8% identity in 226 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TWK4	No	cell wall and cell processes							IPR013078	Q7TWK4	A0A1R3Y412				Rv3390		Rv3390			
NC_002945.3	Mycobrowser_v4	CDS	3757958	3759910	.	+	0	Mb3423	acrA1		POSSIBLE MULTI-FUNCTIONAL ENZYME WITH ACYL-CoA-REDUCTASE ACTIVITY ACRA1	Mb3423, acrA1, len: 650 aa. Equivalent to Rv3391,len: 650 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 650 aa overlap). Possible acrA1, multi functional protein with fatty acyl-CoA reductase activity in C-terminal part (EC 1.2.1.-). Indeed C-terminal part highly similar to P94129|ACR1 FATTY ACYL-COA REDUCTASE from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 767, E(): 1.4e-36, (45.4% identity in 260 aa overlap); and similar to other oxidoreductases dehydrogenases/reductases e.g. Q9Y3A1 CGI-93 PROTEIN (SIMILARITY WITH SDR FAMILY) from Homo sapiens (Human) (291 aa), FASTA scores: opt: 363, E(): 1.5e-13, (38.65% identity in 194 aa overlap); Q9L146|SC6D11.09 PUTATIVE OXIDOREDUCTASE (SIMILARITY WITH SDR FAMILY) from Streptomyces coelicolor (343 aa), FASTA scores: opt: 346,E(): 1.6e-12, (30.4% identity in 283 aa overlap); Q9HSR4|YUSZ1|VNG0115G OXIDOREDUCTASE from Halobacterium sp. strain NRC-1 (260 aa), FASTA scores: opt: 338, E(): 3.7e-12, (33.85% identity in 248 aa overlap); etc. C-terminus also similar to Mycobacterium tuberculosis proteins Q10783|YF43_MYCTU|Rv1543|MTCY48.22c PUTATIVE OXIDOREDUCTASE (341 aa), FASTA scores: opt: 787, E(): 1.2e-37, (39.8% identity in 319 aa overlap); O06413|Rv0547c|MTCY25D10.26c HYPOTHETICAL 31.8 KDA PROTEIN (294 aa), FASTA scores: opt: 565, E(): 4.7e-25, (36.8% identity in 242 aa overlap); O53398|Rv1050|MTV017.03 OXIDOREDUCTASE (SDR FAMILY) (301 aa), FASTA scores: opt: 436, E(): 1.1e-17, (32.2% identity in 292 aa overlap). N-terminus (aa 1-320) is similar to P37693|HETM_ANASP polyketide synthase hetM from Anabaena sp. (506 aa), FASTA scores: opt: 188, E(): 1.3e-07, (27.7% identity in 361 aa overlap); so certainly a multi-domain enzyme. SEEMS TO BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Note that this ORF corresponds to the gene ORF2|Q11197 (in citation mentioned below), but longer 266 aa, due to use of a more upstream start site.	Q7TWK3	No								IPR002198,IPR002347,IPR013120,IPR016040	Q7TWK3	A0A1R3Y424									
NC_002945.3	Mycobrowser_v4	CDS	3759911	3760774	.	-	0	Mb3424c	cmaA1		CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 CMAA1 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1)	Mb3424c, cmaA1, len: 287 aa. Equivalent to Rv3392c,len: 287 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 287 aa overlap). cmaA1, cyclopropane mycolic acid synthase 1 (EC 2.1.1.79), characterized in 1995 as CFA1_MYCTU|Q11195|CMAA1|CMA1 cyclopropane-fatty-acyl-phospholipid synthase 1 (see citations below). Highly similar to Mycobacterium tuberculosis proteins MTCY20H10.23c (58.7% identity in 286 aa overlap); MTCY20H10.24c (68.6% identity); MTCY20H10.25c (73.5% identity); MTCY20H10.26c (57.0% identity); and MTCY20G9.30c (55.7% identity). Also highly similar to Q9CBK3|MMAA4|ML1903 METHYL MYCOLIC ACID SYNTHASES from Mycobacterium leprae (298 aa), FASTA scores: opt: 1098,E(): 1e-63, (57.0% identity in 286 aa overlap). Equivalent to AAK44898|MT0672 from Mycobacterium tuberculosis strain CDC1551 (317 aa) but shorter 30 aa and with some differences in residues between the proteins.	Q7TWK2	No								IPR003333	Q7TWK2	A0A1R3Y428									
NC_002945.3	Mycobrowser_v4	CDS	3792822	3794048	.	-	0	Mb3457c	alr		alanine racemase alr	Mb3457c, alr, len: 408 aa. Equivalent to Rv3423c,len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 408 aa overlap). Probable alr, alanine racemase (EC 5.1.1.1), equivalent to P38056|ALR_MYCLE|ML0375|B229_C3_243 ALANINE RACEMASE from Mycobacterium leprae (388 aa), FASTA scores: opt: 2160,E(): 2.3e-124, (84.35% identity in 384 aa overlap). Also highly similar to other alanine racemases e.g. Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa), FASTA scores: opt: 2103, E(): 6.8e-121, (83.6% identity in 384 aa overlap); P94967|ALR_MYCSM from M. smegmatis (389 aa),FASTA scores: opt: 1721, E(): 1.3e-97, (67.25% identity in 385 aa overlap); O86786|ALR_STRCO|SC6G4.23 from Streptomyces coelicolor (391 aa), FASTA scores: opt: 1041,E(): 3.7e-56, (47.65% identity in 380 aa overlap); etc. BELONGS TO THE ALANINE RACEMASE FAMILY.	X2BNP3,P0A4X3	No									X2BNP3,P0A4X3	P0A4X3									
NC_002945.3	Mycobrowser_v4	CDS	3764838	3766415	.	-	0	Mb3429c	guaA		PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] GUAA (GLUTAMINE AMIDOTRANSFERASE) (GMP SYNTHETASE)	Mb3429c, guaA, len: 525 aa. Equivalent to Rv3396c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable guaA, gmp synthase (EC 6.3.5.2) (see citation below), equivalent to P46810|GUAA_MYCLE|ML0395|B1620_C2_205 GMP SYNTHASE [GLUTAMINE-HYDROLYZING] from Mycobacterium leprae (529 aa), FASTA scores: opt: 2992, E(): 8.5e-168, (86.85% identity in 525 aa overlap). Also highly similar to others e.g. O52831|GUAA_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (524 aa), FASTA scores: opt: 2636, E(): 5.9e-147, (76.2% identity in 521 aa overlap); Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa),FASTA scores: opt: 2451, E(): 4.1e-136, (71.55% identity in 513 aa overlap); Q9KF78|GUAA_BACHD from Bacillus Halodurans (513 aa), FASTA scores: opt: 1819, E(): 4.1e-99, (52.55% identity in 510 aa overlap); etc. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO THE TYPE-1 GLUTAMINE AMIDOTRANSFERASE FAMILY IN THE N-TERMINAL SECTION. AND BELONGS TO THE GMP SYNTHASE FAMILY IN THE C-TERMINAL SECTION.	X2BPF9,P0A5A2	No									X2BPF9,P0A5A2	P0A5A2									
NC_002945.3	Mycobrowser_v4	CDS	3766427	3767335	.	-	0	Mb3430c	phyA		PROBABLE PHYTOENE SYNTHASE PHYA	Mb3430c, phyA, len: 302 aa. Equivalent to Rv3397c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Probable phyA (alternate gene name: crtB), phytoene synthase (EC 2.5.1.-), similar to many e.g. Q9X7V5|SC6A5.09 from Streptomyces coelicolor (312 aa), FASTA scores: opt: 791,E(): 2.8e-43, (48.25% identity in 286 aa overlap); Q9RW07|DR0862 from Deinococcus radiodurans (325 aa), FASTA scores: opt: 482, E(): 1.5e-23, (35.25% identity in 292 aa overlap); Q9JRU9|NMB1168|NMB1130 from Neisseria meningitidis (serogroup B) (290 aa), FASTA scores: opt: 446, E(): 2.8e-21, (34.25% identity in 260 aa overlap); P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419 aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339 PUTATIVE POLY-ISOPRENYL TRANSFERASE (EC 2.5.1.) from Neisseria meningitidis (serogroup A) (290 aa), FASTA scores: opt: 450, E(): 1.6e-21, (34.6% identity in 260 aa overlap). Contains PS01045 Squalene and phytoene synthases signature 2. BELONGS TO THE PHYTOENE/SQUALENE SYNTHETASE FAMILY.	X2BN51,P65861	No									X2BN51,P65861	P65861									
NC_002945.3	Mycobrowser_v4	CDS	3787520	3787828	.	+	0	Mb3450	whiB3		transcriptional regulatory protein whib-like whib3. contains [4fe-4s] cluster.	Mb3450, whiB3, len: 102 aa. Equivalent to Rv3416,len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 102 aa overlap). whiB3 (alternate gene name: whmB), WhiB-like regulatory protein (see citations below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_137 PROBABLE TRANSCRIPTION FACTOR WHIB3 from Mycobacterium leprae (102 aa), FASTA scores: opt: 657, E(): 7.9e-39, (86.25% identity in 102 aa overlap). Also highly similar to Q9Z6E9|WHIB3 from Mycobacterium smegmatis (96 aa), FASTA scores: opt: 604, E(): 3.5e-35, (80.4% identity in 102 aa overlap); and O88103|WHID|SC6G4.45c|WBLB from Streptomyces coelicolor (112 aa), FASTA scores: opt: 437, E(): 1.4e-23,(62.5% identity in 96 aa overlap). Also similar to O05847|WHIB1|Rv3219|MTCY07D11.07c from Mycobacterium tuberculosis (84 aa), FASTA scores: opt: 215, E(): 2.5e-08, (44.45% identity in 81 aa overlap). Note that primer extension analysis revealed three transcriptional start sites and that expression from the three potential promoters is growth phase-dependent (see third citation).	X2BPI5,Q7TWJ2	No									X2BPI5,Q7TWJ2	Q7TWJ2									
NC_002945.3	Mycobrowser_v4	CDS	3767364	3768443	.	-	0	Mb3431c	idsA1		PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE): DIMETHYLALLYLTRANSFERASE (PRENYLTRANSFERASE) (GERANYL-DIPHOSPHATE SYNTHASE) + GERANYLTRANSTRANSFERASE (FARNESYL-DIPHOSPHATE SYNTHASE) (FARNESYL-PYROPHOSPHATE SYNTHETASE) (FARNESYL DIPHOSPHATE SYNTHETASE) (FPP SYNTHETASE) + FARNESYLTRANSTRANSFERASE (GERANYLGERANYL-DIPHOSPHATE SYNTHASE)	Mb3431c, idsA1, len: 359 aa. Equivalent to Rv3398c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable idsA1,geranylgeranyl pyrophosphate synthetase (GGPP synthetase) including: dimethylallyltransferase (EC 2.5.1.1),geranyltranstransferase (EC 2.5.1.10), and farnesyltranstransferase (EC 2.5.1.29). Most similar to AE000797_3|O26156|Q53479 bifunctional short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrop (325 aa), FASTA scores: opt: 605, E(): 0,(37.1% identity in 329 aa overlap); homology suggests ATG at 30121 or TTG at 30145 to be the initiation codon. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY; BELONGS TO A FAMILY THAT GROUPS TOGETHER FPP SYNTHETASE, GGPP SYNTHETASE AND HEXAPRENYL PYROPHOSPHATE SYNTHETASE. Note that previously known as idsA.	X2BNK9,P0A5H9	No									X2BNK9,P0A5H9	P0A5H9									
NC_002945.3	Mycobrowser_v4	CDS	3840431	3840727	.	+	0	Mb3504	PE31		pe family protein pe31	Mb3504, PE31, len: 98 aa. Equivalent to Rv3477,len: 98 aa, from Mycobacterium tuberculosis strain H37Rv,(99.0% identity in 98 aa overlap). Member of the M. tuberculosis PE family, similar to O53941|Rv1791|MTV049.13 (99 aa), FASTA scores: opt: 373, E(): 4.3e-18, (64.65% identity in 99 aa overlap); MTCI364.07; MTCY21C12.10c; MTCY1A11.25c; MTC1A11.04; MTCY359.33; etc.	Q7TWF6	No	PE/PPE							IPR000084	Q7TWF6	A0A1R3Y4D3				Rv3477		Rv3477			
NC_002945.3	Mycobrowser_v4	CDS	3778880	3779179	.	+	0	Mb3441	vapb47		possible antitoxin vapb47	Mb3441, -, len: 99 aa. Equivalent to Rv3407, len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Hypothetical protein,similar to other hypothetical proteins from M. tuberculosis strains H37Rv and CDC1551 e.g. AAK46285|MT2013 (90 aa), FASTA scores: opt: 160, E(): 0.00021, (37.1% identity in 89 aa overlap); O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 155, E(): 0.00051, (41.05% identity in 78 aa overlap),MTCY19H5.26, MTCY20H10.07, MTI376.09c, MTCY427.21, etc.	X2BN63	No	virulence, detoxification, adaptation								X2BN63	P65078				Rv3407		Rv3407			
NC_002945.3	Mycobrowser_v4	CDS	3779619	3781355	.	-	0	Mb3443c	choD		cholesterol oxidase chod (cholesterol-o2 oxidoreductase)	Mb3443c, choD, len: 578 aa. Equivalent to Rv3409c,len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 578 aa overlap). Probable choD,cholesterol oxidase precursor (EC 1.1.3.6), equivalent to Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae (569 aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6% identity in 569 aa overlap). Also highly similar to Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101,E(): 5.2e-57, (60.05% identity in 586 aa overlap); and similar to other oxidoreductases e.g. Q9A7T6|CC1634 OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2% identity in 583 aa overlap). BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN. Contains PS00017 ATP/GTP-binding site motif A.	Q7TWJ4	No								IPR006076,IPR007867	Q7TWJ4	A0A1R3Y431									
NC_002945.3	Mycobrowser_v4	CDS	3781411	3782538	.	-	0	Mb3444c	guaB3		PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB3 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD)	Mb3444c, guaB3, len: 375 aa. Equivalent to Rv3410c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Probable guaB3,inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), equivalent to Q49721|YY10_MYCLE|ML0388|B1620_C2_193 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium leprae (375 aa), FASTA scores: opt: 2182, E(): 9.5e-122, (90.6% identity in 373 aa overlap). Highly similar to Q9RHY9 GUAB ORF GENES FOR IMP DEHYDROGENASE, HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (376 aa), FASTA scores: opt: 1490, E(): 7.6e-81, (61.0% identity in 382 aa overlap); Q9L0I6|SCD63.03 PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1275, E(): 3.8e-68, (52.95% identity in 372 aa overlap); P73853|GUAB|SLR1722 IMP DEHYDROGENASE SUBUNIT from Synechocystis sp. strain PCC 6803 (387 aa), FASTA scores: opt: 882, E(): 6.7e-45, (41.3% identity in 373 aa overlap); and similar to other inosine-5'-monophosphate dehydrogenases e.g. P44334|IMDH_HAEIN|GUAB|HI0221 from Haemophilus influenzae (488 aa), FASTA scores: opt: 267,E(): 1.8e-08, (34.25% identity in 216 aa overlap); etc. Also highly similar to the C-terminus of Q50753|GUAA/B HOMOLOGY TO Mycobacterium leprae GUAA (FRAGMENT) from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 506, E(): 4.6e-23, (85.05% identity in 87 aa overlap). SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO GMP REDUCTASE.	X2BNX6,P65171	No									X2BNX6,P65171	P65171									
NC_002945.3	Mycobrowser_v4	CDS	3782558	3784147	.	-	0	Mb3445c	guaB2		PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB2 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD)	Mb3445c, guaB2, len: 529 aa. Equivalent to Rv3411c,len: 529 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 529 aa overlap). Probable guaB2,inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), equivalent to Q49729|IMDH_MYCLE|GUAB|ML0387|B1620_C3_238 INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE from Mycobacterium leprae (529 aa), FASTA scores: opt: 3154, E(): 4.4e-165,(92.45% identity in 529 aa overlap). Highly similar to other inosine-5'-monophosphate dehydrogenases e.g. Q9RHZ0|GUAB from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (506 aa), FASTA scores: opt: 2284, E(): 1.5e-117, (67.9% identity in 505 aa overlap); Q9L0I7|SCD63.02 from Streptomyces coelicolor (501 aa),FASTA scores: opt: 2178, E(): 9e-112, (67.2% identity in 491 aa overlap); O67820|IMDH_AQUAE|GUAB|AQ_2023 from Aquifex aeolicus (490 aa), FASTA scores: opt: 1820, E(): 3.2e-92, (58.1% identity in 487 aa overlap); etc. Also similar to Q50716|YY10_MYCTU|Rv3410c|MT3518|MTCY78.18 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium tuberculosis (38.6% identity in 158 aa overlap). Contains PS00487 IMP dehydrogenase / GMP reductase signature. SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO GMP REDUCTASE.	X2BPI0,P65168	No									X2BPI0,P65168	P65168									
NC_002945.3	Mycobrowser_v4	CDS	3785666	3786304	.	-	0	Mb3448c	sigD		PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA-D FACTOR SIGD	Mb3448c, sigD, len: 212 aa. Equivalent to Rv3414c,len: 212 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 212 aa overlap). Probable sigD,alternative RNA polymerase sigma-D factor (see citation below), similar to others (notably from Streptomyces coelicolor) e.g. Q9L0I8|SCD63.01 from Streptomyces coelicolor (195 aa), FASTA scores: opt: 533, E(): 9.6e-28,(47.25% identity in 182 aa overlap); Q9FDS3|ADSA from Streptomyces griseus (258 aa), FASTA scores: opt: 223,E(): 1.8e-07, (28.95% identity in 183 aa overlap); BAB48649|MLL1224 from Rhizobium loti (Mesorhizobium loti) (187 aa), FASTA scores: opt: 202, E(): 3.2e-06, (30.4% identity in 194 aa overlap); P38133|RPOE_STRCO|SIGE|SCE94.07 from Streptomyces coelicolor (176 aa), FASTA scores: opt: 200, E(): 4.1e-06,(35.25% identity in 156 aa overlap); P37978|CNRH_ALCEU from Alcaligenes eutrophus (Ralstonia eutropha), FASTA scores: opt: 197, E(): 6.9e-06, (30.35% identity in 191 aa overlap); etc. C-terminus strongly similar to N-terminal part of Q49727|S1620B|B1620_C3_233 HYPOTHETICAL 6.2 KDA PROTEIN from Mycobacterium leprae (59 aa), FASTA scores: opt: 217, E(): 1.3e-07, (90.25% identity in 41 aa overlap). BELONGS TO THE SIGMA-70 FACTOR FAMILY.	X2BND5,P66812	No									X2BND5,P66812	P66812									
NC_002945.3	Mycobrowser_v4	CDS	3787900	3789519	.	-	0	Mb3451c	groEL1		60 KDA CHAPERONIN 1 GROEL1 (PROTEIN CPN60-1) (GROEL PROTEIN 1)	Mb3451c, groEL1, len: 539 aa. Equivalent to Rv3417c, len: 539 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 539 aa overlap). groEL1 (alternate genbe name: cpn60_1), 60 kd chaperonin 1 (protein cpn60 1) (see citations below), equivalent to P37578|CH61_MYCLE|B1620_C3_228|GROL1|GROEL1|GROEL-1|GROE1|ML0381|B229_ 60 KDA CHAPERONIN 1 from Mycobacterium leprae (537 aa), FASTA scores: opt: 2846,E(): 1.5e-154, (82.95% identity in 539 aa overlap). Also highly similar to others e.g. Q00767|CH61_STRAL|GROL1|GROEL1 from Streptomyces albus G (539 aa), FASTA scores: opt: 2130, E(): 8.1e-114, (61.9% identity in 541 aa overlap); P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces coelicolor (540 aa), FASTA scores: opt: 2119, E(): 3.4e-113, (61.8% identity in 542 aa overlap); etc. Also similar to P06806|CH62_MYCTU|Q48931|Rv0440|MTV037.04|GROL2|GROEL2|GRO EL-2|HSP65 (62.2% identity in 527 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, PS00296 Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY.	X2BN75,P0A519	No	virulence, detoxification, adaptation								X2BN75,P0A519	P0A519				Rv3417c		Rv3417c			
NC_002945.3	Mycobrowser_v4	CDS	3789614	3789916	.	-	0	Mb3452c	groES		10 KDA CHAPERONIN GROES (PROTEIN CPN10) (PROTEIN GROES) (BCG-A HEAT SHOCK PROTEIN) (10 KDA ANTIGEN)	Mb3452c, groES, len: 100 aa. Equivalent to Rv3418c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). groES (alternate gene names: cpn10, mpt57), 10 kDa chaperonin (protein cpn10) (see citations below), equivalent to P24301|CH10_MYCLE|MOPB|GROES|CHPA|ML0380|B1620_C3_227|B229 _C3_247 from Mycobacterium leprae (99 aa), FASTA scores: opt: 568, E(): 2.1e-31, (89.9% identity in 99 aa overlap). And also strongly identical to others e.g. O86017|CH10_MYCAV|MOPB|GROES from Mycobacterium avium and Mycobacterium paratuberculosis (99 aa), FASTA scores: opt: 611, E(): 2.9e-34, (96.95% identity in 99 aa overlap); P15020|CH10_MYCBO|MOPB|GROES from Mycobacterium bovis (99 aa), FASTA scores: opt: 596, E(): 2.9e-33, (98.95% identity in 94 aa overlap); P40172|CH10_STRCO|GROES|SC6G4.39 from Streptomyces coelicolor and Streptomyces lividans (102 aa), FASTA scores: opt: 480, E(): 1.6e-25, (76.75% identity in 99 aa overlap); etc. Also identical to MSG10KAG_1, MT10KAG_1,MTBCGA_1. Contains PS00681 Chaperonins cpn10 signature. BELONGS TO THE GROES CHAPERONIN FAMILY.	X2BNN5,P15020	No									X2BNN5,P15020	P15020									
NC_002945.3	Mycobrowser_v4	CDS	3790183	3791217	.	-	0	Mb3453c	gcp		PROBABLE O-SIALOGLYCOPROTEIN ENDOPEPTIDASE GCP (GLYCOPROTEASE)	Mb3453c, -, len: 344 aa. Equivalent to Rv3419c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable gcp,glycoprotease (EC 3.4.24.57), equivalent to P37969|GCP_MYCLE|GCP|ML0379|U229E|U1620c|B229_C3_246|B1620 _C3_226 PROBABLE GLYCOPROTEASE from Mycobacterium leprae (351 aa), FASTA scores: opt: 1898, E(): 2.4e-101, (86.1% identity in 345 aa overlap). Highly similar to others e.g. O86793|GCP_STRCO|GCP|SC6G4.30 from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1282, E(): 4.1e-66, (60.45% identity in 344 aa overlap); Q9WXZ2|TM0145 from Thermotoga maritima (327 aa), FASTA scores: opt: 867, E(): 1.9e-42,(45.4% identity in 337 aa overlap); P05852|GCP_ECOLI|B3064 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 838, E(): 9e-41, (46.55% identity in 346 aa overlap); etc. Shows some similarity to Q50707|YY21_MYCTU|Rv3421c|MTCY78.08 (33.9% identity in 127 aa overlap). Contains PS01016 Glycoprotease family signature. BELONGS TO PEPTIDASE FAMILY M22; ALSO KNOWN AS THE GLYCOPROTEASE FAMILY.	X2BNE0,P65802	No	intermediary metabolism and respiration								X2BNE0,P65802	P65802				Rv3419c		Rv3419c			
NC_002945.3	Mycobrowser_v4	CDS	3791214	3791690	.	-	0	Mb3454c	rimI		ribosomal-protein-alanine acetyltransferase rimi (acetylating enzyme for n-terminal of ribosomal protein s18)	Mb3454c, rimI, len: 158 aa. Equivalent to Rv3420c,len: 158 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 158 aa overlap). Probable rimI,ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), equivalent to C-terminal part of Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: opt: 772, E(): 2.7e-44, (72.1% identity in 154 aa overlap). Similar notably to ribosomal-protein-alanine acetyltransferases e.g. Q9AC11|CC0058 from Caulobacter crescentus (150 aa), FASTA scores: opt: 223, E(): 4.9e-08,(37.5% identity in 136 aa overlap); Q9KFD4|BH0547 from Bacillus halodurans (151 aa), FASTA scores: opt: 222, E(): 5.8e-08, (35.2% identity in 142 aa overlap); Q9PG61|XF0441 from Xylella fastidiosa (156 aa), FASTA scores: opt: 207,E(): 5.9e-07, (32.2% identity in 149 aa overlap); Q9HVB7|RIMI|PA4678 from Pseudomonas aeruginosa (150 aa),FASTA scores: opt: 203, E(): 1.1e-06, (32.45% identity in 151 aa overlap); P09453|RIMI_ECOLI|B4373 from Escherichia coli strain K12 (148 aa), FASTA scores: opt: 196, E(): 3.1e-06, (33.55% identity in 149 aa overlap); etc. BELONGS TO THE ACETYLTRANSFERASE FAMILY, RIMI SUBFAMILY.	Q7TWJ1	No								IPR000182,IPR006464,IPR016181	Q7TWJ1	A0A1R3Y448									
NC_002945.3	Mycobrowser_v4	CDS	3794867	3795403	.	+	0	Mb3459	PPE57		ppe family protein ppe57	Mb3459, PPE57, len: 178 aa. Equivalent to 5' end of Rv3425, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv, (90.9% identity in 176 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 781, E(): 7e-44, (69.9% identity in 176 aa overlap); and downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity in 125 aa overlap); MTV049_11, MTCY428_16, MTV049_22,MTV049_30, MTCY261_4; etc. Rv3429: Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end)); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58,Rv3427c, Rv3428c and PPE59 compared to Mycobacterium tuberculosis strain H37Rv.	Q7TWJ0	No								IPR000030	Q7TWJ0	A0A1R3Y451									
NC_002945.3	Mycobrowser_v4	CDS	3798074	3799456	.	-	0	Mb3462c	gadB		PROBABLE GLUTAMATE DECARBOXYLASE GADB	Mb3462c, gadB, len: 460 aa. Equivalent to Rv3432c,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 460 aa overlap). Probable gadB,glutamate decarboxylase (EC 4.1.1.15), similar to many e.g. P73043|GAD|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99,(55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|GAD from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15% identity in 437 aa overlap); etc. BELONGS TO GROUP II DECARBOXYLASES (DDC, GAD, HDC AND TYRDC).	Q7TWI7	No								IPR002129,IPR010107,IPR015421,IPR015424	Q7TWI7	A0A1R3Y460									
NC_002945.3	Mycobrowser_v4	CDS	3816053	3817456	.	+	0	Mb3478	eccd4		esx conserved component eccd4. esx-4 type vii secretion system protein. probable integral membrane protein.	Mb3478, -, len: 467 aa. Equivalent to Rv3448, len: 467 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 467 aa overlap). Probable conserved integral membrane protein, showing some similarity with Q9CD35|ML2529 from Mycobacterium leprae (485 aa), FASTA scores: opt: 371, E(): 3.6e-14, (27.25% identity in 481 aa overlap); and two proteins from Mycobacterium tuberculosis O86362|Rv0290|MTV035.18 (472 aa), FASTA scores: opt: 429,E(): 1.6e-17, (28.6% identity in 479 aa overlap); and O05457|Rv3887c|MTCY15F10.25 (509 aa), FASTA scores: opt: 203, E(): 0.00019, (25.6% identity in 492 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.	Q7TWH4	No	cell wall and cell processes							IPR006707,IPR024962	Q7TWH4	A0A1R3Y4X5				Rv3448		Rv3448			
NC_002945.3	Mycobrowser_v4	CDS	3802717	3804591	.	-	0	Mb3466c	glmS		PROBABLE GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] GLMS (HEXOSEPHOSPHATE AMINOTRANSFERASE) (D-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE) (GFAT) (L-GLUTAMINE-D-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE) (GLUCOSAMINE-6-PHOSPHATE SYNTHASE)	Mb3466c, glmS, len: 624 aa. Equivalent to Rv3436c,len: 624 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 624 aa overlap). Probable glmS,glucosamine--fructose-6-phosphate aminotransferase (EC 2.6.1.16), equivalent to P40831|GLMS_MYCLE|ML0371|B229_C3_238 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] from Mycobacterium leprae (623 aa), FASTA scores: opt: 3584, E(): 4.7e-214, (89.3% identity in 627 aa overlap). Also highly similar to others e.g. O68956|GLMS_MYCSM from Mycobacterium smegmatis (627 aa),FASTA scores: opt: 3517, E(): 6.5e-210, (87.25% identity in 627 aa overlap); O86781|GLMS_STRCO|SC6G4.18 from Streptomyces coelicolor (614 aa), FASTA scores: opt: 2364,E(): 1.3e-138, (64.95% identity in 625 aa overlap); Q9K1P9|NMB0031 from Neisseria meningitidis (serogroup B) and Q9JWN9|GLMS|NMA0276 from Neisseria meningitidis (serogroup A) (612 aa), FASTA scores: opt: 1445, E(): 8.4e-82, (43.55% identity in 627 aa overlap); etc. BELONGS TO THE TYPE-2 GATASE DOMAIN IN THE N-TERMINAL SECTION. BELONGS TO THE SIS FAMILY, GLMS SUBFAMILY, IN THE C-TERMINAL SECTION.	X2BNB0,P0A589	No									X2BNB0,P0A589	P0A589									
NC_002945.3	Mycobrowser_v4	CDS	3807726	3809072	.	-	0	Mb3471c	mrsA		PROBABLE PHOSPHO-SUGAR MUTASE / MRSA PROTEIN HOMOLOG	Mb3471c, mrsA, len: 448 aa. Equivalent to Rv3441c,len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 448 aa overlap). Probable mrsA,phosphoglucomutase or phosphomannomutase (EC 5.4.2.-),equivalent to Q49869|URED|B229_C3_234 MRSA PROTEIN HOMOLOG from Mycobacterium leprae (463 aa), FASTA scores: opt: 2449, E(): 6.3e-135, (87.65% identity in 445 aa overlap); and highly similar (but longer 178 aa) to Q49862|UREC|B229_C2_192 PUTATIVE UREASE OPERON UREC PROTEIN from Mycobacterium leprae (288 aa), FASTA scores: opt: 1442, E(): 1.3e-76, (86.5% identity in 267 aa overlap). Highly similar to phospho-sugar mutases e.g. Q53876|SC6G4.14 PUTATIVE PHOSPHO-SUGAR MUTASE (SIMILAR TO PHOSPHOMANNOMUTASES) from Streptomyces coelicolor (452 aa), FASTA scores: opt: 1710, E(): 5e-92, (60.45% identity in 450 aa overlap); Q9KG46|BH0267 PHOSPHOGLUCOSAMINE MUTASE from Bacillus halodurans (447 aa), FASTA scores: opt: 1351, E(): 3.5e-71, (48.4% identity in 444 aa overlap); BAB58323|GLMM PHOSPHOGLUCOSAMINE-MUTASE from Staphylococcus aureus subsp. aureus Mu50 (451 aa) and Q99QR5|GLMM(FEMD)|SA1965 PHOSPHOGLUCOSAMINE-MUTASE from Staphylococcus aureus subsp. aureus N315. (451 aa), FASTA scores: opt: 1315, E(): 4.3e-69, (48.45% identity in 446 aa overlap); P95685|FEMD|GLMM PHOSPHOGLUCOSAMINE-MUTASE (451 aa), FASTA scores: opt: 1310, E(): 8.5e-69, (48.2% identity in 446 aa overlap); P95575|MRSA_PSESY MRSA PROTEIN HOMOLOG from Pseudomonas syringae (pv. syringae) (447 aa), FASTA scores: opt: 1143, E(): 4.2e-59, (42.75% identity in 447 aa overlap); etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY.	X2BNC0,Q7TWH9	No									X2BNC0,Q7TWH9	Q7TWH9									
NC_002945.3	Mycobrowser_v4	CDS	3821153	3821833	.	+	0	Mb3482	cut4		PROBABLE CUTINASE PRECURSOR CUT4	Mb3482, cut4, len: 226 aa. Equivalent to Rv3452,len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 226 aa overlap). Probable cut4,cutinase precursor (EC 3.1.1.-), similar to other e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 522, E(): 7.3e-24, (46.6% identity in 221 aa overlap); P30272|CUTI_MAGGR|CUT1 from Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) (228 aa), FASTA scores: opt: 205, E(): 3.8e-05, (29.25% identity in 164 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 204,E(): 3.9e-05, (33.5% identity in 209 aa overlap); etc. Similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 773, E(): 1.3e-38, (59.35% identity in 209 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 704, E(): 1.3e-34, (53.4% identity in 219 aa overlap); etc. Contains PS00155 Cutinase, serine active site. BELONGS TO THE CUTINASE FAMILY. Alternative start possible at 4553 in cSCY13E12 but no RBS.	Q7TWH1	No	cell wall and cell processes							IPR000675	Q7TWH1	A0A1R3Y473				Rv3452		Rv3452			
NC_002945.3	Mycobrowser_v4	CDS	3809197	3809652	.	-	0	Mb3472c	rpsI		30s ribosomal protein s9 rpsi	Mb3472c, rpsI, len: 151 aa. Equivalent to Rv3442c,len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Probable rpsI,ribosomal protein S9, equivalent to P40828|RS9_MYCLE|ML0365|B229_C2_191 30S RIBOSOMAL PROTEIN S9 (153 aa), FASTA scores: opt: 800, E(): 2.1e-42, (83.85% identity in 155 aa overlap). Also highly similar to others e.g. Q53875|RS9_STRCO|SC6G4.13 from Streptomyces coelicolor (170 aa), FASTA scores: opt: 533, E(): 5.7e-26,(60.75% identity in 135 aa overlap); Q9KGD4|RPSI|BH0169 (BS10) from Bacillus halodurans (130 aa), FASTA scores: opt: 469, E(): 3.8e-22, (58.65% identity in 121 aa overlap); Q9CDG7|RPSI from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (130 aa), FASTA scores: opt: 451, E(): 4.9e-21, (58.65% identity in 121 aa overlap); P07842|RS9_BACST|RPSI from Bacillus stearothermophilus (129 aa), FASTA scores: opt: 448, E(): 7.4e-21, (54.55% identity in 121 aa overlap); etc. Contains PS00360 Ribosomal protein S9 signature. BELONGS TO THE S9P FAMILY OF RIBOSOMAL PROTEINS.	X2BNU0,P66640	No									X2BNU0,P66640	P66640									
NC_002945.3	Mycobrowser_v4	CDS	3809649	3810092	.	-	0	Mb3473c	rplM		50s ribosomal protein l13 rplm	Mb3473c, rplM, len: 147 aa. Equivalent to Rv3443c,len: 147 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 147 aa overlap). Probable rplM, 50S ribosomal protein L13, equivalent to P38014|RL13_MYCLE|RPLM|ML0364|B229_C3_232 from Mycobacterium leprae (147 aa), FASTA scores: opt: 917,E(): 7.5e-53, (91.15% identity in 147 aa overlap). Also highly similar to others e.g. Q53874|RL13_STRCO|RPLM|SC6G4.12 from Streptomyces coelicolor (147 aa), FASTA scores: opt: 668, E(): 1.1e-36,(65.5% identity in 145 aa overlap); Q9X1G5|RL13_THEMA|RPLM|TM1454 from Thermotoga maritima (149 aa), FASTA scores: opt: 536, E(): 4.4e-28, (53.65% identity in 136 aa overlap); O67722|RL13_AQUAE|RPLM|AQ_1877 from Aquifex aeolicus (144 aa), FASTA scores: opt: 529, E(): 1.2e-27, (53.2% identity in 141 aa overlap); etc. BELONGS TO THE L13P FAMILY OF RIBOSOMAL PROTEINS.	X2BNH1,P66066	No									X2BNH1,P66066	P66066									
NC_002945.3	Mycobrowser_v4	CDS	3810325	3810627	.	-	0	Mb3474c	esxT		putative esat-6 like protein esxt	Mb3474c, esxT, len: 100 aa. Equivalent to Rv3444c,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). esxT, conserved hypothetical protein, equivalent to Q9CCV7|ML0363 POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (104 aa), FASTA scores: opt: 362, E(): 1.1e-18, (71.25% identity in 73 aa overlap). C-terminal part highly similar to Q49852|B229_C1_150 HYPOTHETICAL 5.3 KDA PROTEIN from Mycobacterium leprae (49 aa), FASTA scores: opt: 227, E(): 1.4e-09, (68.9% identity in 45 aa overlap).	Q7TWH8	No								IPR010310	Q7TWH8	A0A1R3Y497									
NC_002945.3	Mycobrowser_v4	CDS	3810648	3810965	.	-	0	Mb3475c	esxU		ESAT-6 like protein EsxU	Mb3475c, len: 105 aa. Equivalent to Rv3445c len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). EsxU, ESAT-6 like protein (see citations below), showing weak similarity to O30373|VCD|PA2257 pyoverdine biosynthesis protein from Pseudomonas aeruginosa (215 aa), FASTA scores: opt: 103,E(): 5.6, (32.35% identity in 133 aa overlap). Seems to belong to the ESAT6 family. Start changed since first submission (-20 aa).	X2BPM4	No	cell wall and cell processes								X2BPM4	A0A1R3Y467				Rv3445c		Rv3445c			
NC_002945.3	Mycobrowser_v4	CDS	3812229	3815939	.	-	0	Mb3477c	eccc4		esx conserved component eccc4. esx-4 type vii secretion system protein. probable membrane protein.	Mb3477c, -, len: 1236 aa. Equivalent to Rv3447c,len: 1236 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1236 aa overlap). Probable conserved membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa),FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910,E(): 1.5e-44, (34.4% identity in 1319 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa), FASTA scores: opt: 805, E(): 1.9e-38, (25.85% identity in 1292 aa overlap); etc. The C-terminal region is similar to Q9CDD7|ML0052 (alias O33086|MLCB628.15c) HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 850,E(): 2.3e-41, (35.2% identity in 588 aa overlap); and O6973|Rv3871|MTV027.06 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (591 aa), FASTA scores: opt: 845, E(): 4.3e-41, (35.3% identity in 586 aa overlap). N-terminal part shows similarity with HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. O69735|Rv3870|MTV027.05 (747 aa), FASTA scores: opt: 761,E(): 3.6e-36, (38.2% identity in 746 aa overlap). Equivalent to AAK47893 from Mycobacterium tuberculosis strain CDC1551 (1200 aa) but longer 36 aa. Contains three of PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TWH5	No	cell wall and cell processes							IPR002543,IPR003593,IPR023836,IPR023837,IPR027417	Q7TWH5	A0A1R3Y5W3				Rv3447c		Rv3447c			
NC_002945.3	Mycobrowser_v4	CDS	3984222	3984560	.	-	0	Mb3628c	lsr2		iron-regulated h-ns-like protein lsr2	Mb3628c, lsr2, len: 112 aa. Equivalent to Rv3597c,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Probable lsr2,identical to P24094|LSR2_MYCLE|ML0234 LSR2 PROTEIN PRECURSOR (15 KDA ANTIGEN) (A15) from Mycobacterium leprae (112 aa), FASTA scores: opt: 698, E(): 6.7e-37, (92.85% identity in 112 aa overlap). Also highly similar to others e.g. Q9X8N1|SCE94.26c from Streptomyces coelicolor (111 aa), FASTA scores: opt: 379, E(): 4.4e-17, (58.05% identity in 112 aa overlap); Q9ETI2|LSR2 from Corynebacterium equii (Rhodococcus equi) (119 aa), FASTA scores: opt: 328, E(): 6.9e-14, (47.5% identity in 120 aa overlap); and Q9RKK8|SCD25.12c from Streptomyces coelicolor (105 aa), FASTA scores: opt: 293, E(): 9.4e-12,(47.75% identity in 111 aa overlap).	X2BP54,P65649	No									X2BP54,P65649	P65649									
NC_002945.3	Mycobrowser_v4	CDS	3818785	3820197	.	-	0	Mb3480c	eccb4		esx conserved component eccb4. esx-4 type vii secretion system protein. probable membrane protein.	Mb3480c, -, len: 470 aa. Equivalent to Rv3450c,len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 470 aa overlap). Probable conserved membrane protein (possible membrane spanning region near N-terminus). Similar to hypothetical unknowns proteins from Mycobacterium leprae e.g. O33088|MLCB628.17C|ML0054 HYPOTHETICAL 51.9 KDA PROTEIN (PUTATIVE MEMBRANE PROTEIN)(481 aa), FASTA scores: opt: 708, E(): 6.4e-32,(32.9% identity in 480 aa overlap); Q9CD29|ML2536 (552 aa), FASTA scores: opt: 394, E(): 1.7e-14, (33.6% identity in 503 aa overlap); etc. Also similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O69734|Rv3869|MTV027.04 (480 aa), FASTA scores: opt: 717, E(): 2e-32, (32.55% identity in 479 aa overlap); O05449|Rv3895c|MTCY15F10.17 (495 aa), FASTA scores: opt: 670, E(): 8.3e-30, (36.4% identity in 475 aa overlap); O5368|Rv0283|MTV035.11 (538 aa), FASTA scores: opt: 467, E(): 1.5e-18, (36.3% identity in 493 aa overlap); etc.	Q7TWH2	No	cell wall and cell processes							IPR007795	Q7TWH2	A0A1R3Y4C4				Rv3450c		Rv3450c			
NC_002945.3	Mycobrowser_v4	CDS	3824590	3825132	.	-	0	Mb3485c	rplQ		50s ribosomal protein l17 rplq	Mb3485c, rplQ, len: 180 aa. Equivalent to Rv3456c,len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 180 aa overlap). Probable rplQ, 50S ribosomal protein L17, equivalent to Q9X797|RL17_MYCLE|ML1956|MLCB1222.26c 50S RIBOSOMAL PROTEIN L17 from Mycobacterium leprae (170 aa), FASTA scores: opt: 874, E(): 9.5e-45, (81.85% identity in 171 aa overlap). Also highly similar to other e.g. O86775|RL17_STRCO|SC6G4.08 from Streptomyces coelicolor (168 aa), FASTA scores: opt: 609, E(): 3.7e-29, (60.0% identity in 170 aa overlap); BAB47931|MLR0326 from Rhizobium loti (Mesorhizobium loti) (143 aa), FASTA scores: opt: 404, E(): 3.7e-17, (49.65% identity in 139 aa overlap); Q9Z9H5|RL17_THETH|RPLQ from Thermus aquaticus (subsp. thermophilus) (118 aa), FASTA scores: opt: 366,E(): 5.5e-15, (53.15% identity in 111 aa overlap); P02416|RL17_ECOLI|RPLQ|B3294 from Escherichia coli strain K12 (127 aa), FASTA scores: opt: 347, E(): 7.6e-14, (50.4% identity in 119 aa overlap); etc. BELONGS TO THE L17P FAMILY OF RIBOSOMAL PROTEINS.	X2BPN0,P0A5V5	No									X2BPN0,P0A5V5	P0A5V5									
NC_002945.3	Mycobrowser_v4	CDS	3820318	3821106	.	+	0	Mb3481	cut3		PROBABLE CUTINASE PRECURSOR CUT3	Mb3481, cut3, len: 262 aa. Equivalent to Rv3451,len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Probable cut3,cutinase precursor (EC 3.1.1.-), similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214,E(): 2e-05, (31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203, E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. the downstream ORF O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN (226 aa), FASTA scores: opt: 775, E(): 1e-37, (58.65% identity in 220 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 565, E(): 1.3e-25, (44.85% identity in 223 aa overlap); Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 489, E(): 3e-21, (47.05% identity in 221 aa overlap); etc. Equivalent to AAK47897 from Mycobacterium tuberculosis strain CDC1551 (247 aa) but longer 15 aa. Contains cutinase, serine active site motif (PS00155). BELONGS TO THE CUTINASE FAMILY. Alternative start possible at 3733. Start changed since first submission (+15 aa).	X2BNC9,P0A537	No	cell wall and cell processes								X2BNC9,P0A537	P0A537				Rv3451		Rv3451			
NC_002945.3	Mycobrowser_v4	CDS	3832671	3833765	.	-	0	Mb3497c	rmlB2		possible dtdp-glucose 4,6-dehydratase	Mb3497c, rmlB2, len: 364 aa. Equivalent to Rv3468c,len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 364 aa overlap). Possible rmlB2 (alternate gene name: rfbB), DTDP-glucose-4,6-dehydratase (EC 4.2.1.46), similar to others e.g. O08246|MTME from Streptomyces argillaceus (331 aa), FASTA scores: opt: 238,E(): 1.2e-07, (29.65% identity in 344 aa overlap); Q9LFG7|F4P12_220 from Arabidopsis thaliana (Mouse-ear cress) (433 aa), FASTA scores: opt: 237, E(): 1.8e-07,(27.25% identity in 308 aa overlap); Q9LZI2|F26K9_260 from Arabidopsis thaliana (Mouse-ear cress) (445 aa), FASTA scores: opt: 225, E(): 1e-06, (25.95% identity in 335 aa overlap); etc. Also similar to various enzymes and hypothetical unknowns proteins e.g. BAB48655|MLL1234 UDP-GLUCOSE 4-EPIMERASE from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 757, E(): 4.6e-40,(43.4% identity in 302 aa overlap). First start taken,alternative at 17080 in cSCYY13E12 suggested by similarity. Note that previously known as rmlB3.	Q7TWG3	No								IPR001509,IPR016040	Q7TWG3	A0A1R3Y5Y1									
NC_002945.3	Mycobrowser_v4	CDS	3823752	3824522	.	-	0	Mb3484c	truA		PROBABLE TRNA PSEUDOURIDINE SYNTHASE A TRUA (PSEUDOURIDYLATE SYNTHASE I) (PSEUDOURIDINE SYNTHASE I) (URACIL HYDROLYASE)	Mb3484c, truA, len: 256 aa. Equivalent to Rv3455c,len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Probable truA,pseudouridine synthase A (EC 4.2.1.70), equivalent to Q9X796|TRUA_MYCLE|ML1955|MLCB1222.25c TRNA PSEUDOURIDINE SYNTHASE A from Mycobacterium leprae (249 aa), FASTA scores: opt: 1345, E(): 3.2e-80, (77.25% identity in 246 aa overlap). Also highly similar to others e.g. O86776|TRUA_STRCO|SC6G4.09 from Streptomyces coelicolor (284 aa), FASTA scores: opt: 595, E(): 1.7e-31, (49.8% identity in 259 aa overlap); Q9RS37|DR2290 from Deinococcus radiodurans (280 aa), FASTA scores: opt: 383,E(): 1e-17, (41.2% identity in 216 aa overlap); Q9PJT0|TRUA_CHLMU|TC0748 from Chlamydia muridarum (267 aa), FASTA scores: opt: 334, E(): 1.5e-14, (37.65% identity in 231 aa overlap); P07649|TRUA_ECOLI|HIST|ASUC|LEUK|B2318 from Escherichia coli strain K12 (270 aa), FASTA scores: opt: 315, E(): 2.5e-13, (33.35% identity in 240 aa overlap); etc. BELONGS TO THE TRUA FAMILY OF PSEUDOURIDINE SYNTHASES.	X2BP35,P65847	No									X2BP35,P65847	P65847									
NC_002945.3	Mycobrowser_v4	CDS	3825164	3826207	.	-	0	Mb3486c	rpoA		PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE ALPHA SUBUNIT) (DNA-DIRECTED RNA NUCLEOTIDYLTRANSFERASE)	Mb3486c, rpoA, len: 347 aa. Equivalent to Rv3457c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Probable rpoA, alpha chain of RNA polymerase (EC 2.7.7.6), equivalent to Q9X798|RPOA_MYCLE|ML1957|MLCB1222.27c DNA-DIRECTED RNA POLYMERASE ALPHA from Mycobacterium leprae (347 aa), FASTA scores: opt: 2139, E(): 1.3e-123, (95.65% identity in 347 aa overlap). Also highly similar to others e.g. P72404|RPOA_STRCO|C6G4.07 from Streptomyces coelicolor (340 aa), FASTA scores: opt: 1672, E(): 4.7e-95, (75.55% identity in 348 aa overlap); Q9X4V6|RPOA_STRGT from Streptomyces granaticolor (340 aa), FASTA scores: opt: 1671, E(): 5.4e-95, (75.55% identity in 348 aa overlap); P20429|RPOA_BACSU from Bacillus subtilis (314 aa), FASTA scores: opt: 939, E(): 3e-50, (48.9% identity in 311 aa overlap); etc. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE RNA POLYMERASE ALPHA CHAIN FAMILY.	X2BND1,P66702	No									X2BND1,P66702	P66702									
NC_002945.3	Mycobrowser_v4	CDS	3826355	3826960	.	-	0	Mb3487c	rpsD		30s ribosomal protein s4 rpsd	Mb3487c, rpsD, len: 201 aa. Equivalent to Rv3458c,len: 201 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 201 aa overlap). Probable rpsD, 30S ribosomal protein S4, equivalent to Q9X799|RS4_MYCLE|RPSD|ML1958|MLCB1222.28c 30S RIBOSOMAL PROTEIN S4 from Mycobacterium leprae (201 aa), FASTA scores: opt: 1271, E(): 2.2e-73, (93.5% identity in 201 aa overlap); and P45811|RS4_MYCBO|RPSD from Mycobacterium bovis (131 aa), FASTA scores: opt: 867, E(): 4.9e-48,(100.0% identity in 130 aa overlap). Also highly similar to others e.g. P81288|RS4_BACST|RPSD from Bacillus stearothermophilus (198 aa), FASTA scores: opt: 665, E(): 4e-35, (52.25% identity in 201 aa overlap); Q9K7Z8|RPSD|BH3209 from Bacillus halodurans (200 aa),FASTA scores: opt: 626, E(): 1.2e-32, (48.75% identity in 203 aa overlap); Q9X1I3|RS4_THEMA|RPSD|TM1473 from Thermotoga maritima (209 aa), FASTA scores: opt: 591, E(): 2e-30, (45.0% identity in 209 aa overlap); etc. Contains ribosomal protein S4 signature (PS00632) and ATP/GTP binding site motif (PS00017). BELONGS TO THE S4P FAMILY OF RIBOSOMAL PROTEINS.	X2BNV6,P45811	No									X2BNV6,P45811	P45811									
NC_002945.3	Mycobrowser_v4	CDS	3826969	3827388	.	-	0	Mb3488c	rpsK		30s ribosomal protein s11 rpsk	Mb3488c, rpsK, len: 139 aa. Equivalent to Rv3459c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 139 aa overlap). Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867,E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.	X2BNI4,P45812	No									X2BNI4,P45812	P45812									
NC_002945.3	Mycobrowser_v4	CDS	3827392	3827766	.	-	0	Mb3489c	rpsM		30s ribosomal protein s13 rpsm	Mb3489c, rpsM, len: 124 aa. Equivalent to Rv3460c,len: 124 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 124 aa overlap). Probable rpsM, 30S ribosomal protein S13, equivalent to Q9X7A1|RS13_MYCLE|RPSM|ML1960|MLCB1222.30c 30S RIBOSOMAL PROTEIN S13 from Mycobacterium leprae (124 aa), FASTA scores: opt: 762, E(): 1.5e-43, (92.75% identity in 124 aa overlap); and P45813|RS13_MYCBO|RPSM from Mycobacterium bovis (123 aa), FASTA scores: opt: 727, E(): 3e-41,(98.25% identity in 114 aa overlap). Also highly similar to others e.g. O86773|RS13_STRCO|SC6G4.05 from Streptomyces coelicolor (126 aa), FASTA scores: opt: 631,E(): 6.2e-35, (73.75% identity in 122 aa overlap); Q9RA65|RPS13 from Thermus aquaticus (subsp. thermophilus) (126 aa), FASTA scores: opt: 552, E(): 9.8e-30, (62.6% identity in 123 aa overlap); P20282|RS13_BACSU|RPSM from Bacillus subtilis (120 aa), FASTA scores: opt: 533, E(): 1.7e-28, (64245% identity in 121 aa overlap); etc. Contains ribosomal protein S13 signature (PS00646). BELONGS TO THE S13P FAMILY OF RIBOSOMAL PROTEINS.	X2BP39,P45813	No									X2BP39,P45813	P45813									
NC_002945.3	Mycobrowser_v4	CDS	3883854	3889670	.	+	0	Mb3541	PE_PGRS55		pe-pgrs family protein pe_pgrs56	Mb3541, PE_PGRS55, len: 1938 aa. Equivalent to Rv3511 and Rv3512, len: 714 aa and 1079 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 706 aa overlap and 96.0% identity in 1117 aa overlap). Rv3511: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 2563, E(): 1.5e-94, (59.65% identity in 773 aa overlap); and upstream O53553|Rv3508|MTV023.15 (1901 aa),FASTA scores: opt: 2455, E(): 3.9e-90, (60.4% identity in 737 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. Rv3512: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 3688, E(): 4.5e-130, (53.95% identity in 1136 aa overlap); and downstream O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 3611, E(): 3.6e-127, (53.15% identity in 1195 aa overlap); etc. Frameshifted PGRS protein, could be continuation of upstream MTV023.18, but no error could be found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344 bp insertion results in a single product which is more similar to PE_PGRS55. There are also 3 additional in-frame insertions of 9 bp each (*-accggcgga, *-cggcaacgg and *-cggcggtac) and 2 substitutions compared to the homolog in Mycobacterium tuberculosis strain H37Rv.	Q7TWC0	No								IPR000084	Q7TWC0	A0A1R3Y4H8									
NC_002945.3	Mycobrowser_v4	CDS	3827982	3828095	.	-	0	Mb3490c	rpmJ		50s ribosomal protein l36 rpmj	Mb3490c, rpmJ, len: 37 aa. Equivalent to Rv3461c,len: 37 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 37 aa overlap). Probable rpmJ, 50S ribosomal protein L36, equivalent to P45810|RL36_MYCBO|RPMJ from Mycobacterium bovis (37 aa); and Q9X7A2|RL36_MYCLE|RPMJ|ML1961|MLCB1222.31c 50S RIBOSOMAL PROTEIN L36 from Mycobacterium leprae (37 aa),FASTA scores: opt: 241, E(): 9.7e-14, (86.5% identity in 37 aa overlap). Also highly similar to others e.g. O86772|RL36_STRCO|SC6G4.04 from Streptomyces coelicolor (37 aa), FASTA scores: opt: 233, E(): 4.5e-13, (83.8% identity in 37 aa overlap); P07841|RL36_BACST|RPMJ from Bacillus stearothermophilus (37 aa), FASTA scores: opt: 214, E(): 1.6e-11, (72.95% identity in 37 aa overlap); P12230|RK36_SPIOL|RPL36 from Spinacia oleracea (Spinach) (37 aa), FASTA scores: opt: 211, E(): 2.9e-11, (70.25% identity in 37 aa overlap); etc. Contains PS00828 Ribosomal protein L36 signature. BELONGS TO THE L36P FAMILY OF RIBOSOMAL PROTEINS.	X2BPN4,P0A5W7	No									X2BPN4,P0A5W7	P0A5W7									
NC_002945.3	Mycobrowser_v4	CDS	3828128	3828349	.	-	0	Mb3491c	infA		PROBABLE TRANSLATION INITIATION FACTOR IF-1 INFA	Mb3491c, infA, len: 73 aa. Equivalent to Rv3462c,len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Probable infA,initiation factor IF-1, equivalent to P45957|ML1962|INFA TRANSLATION INITIATION FACTOR IF-1 from Mycobacterium bovis (72 aa) and Mycobacterium leprae (72 aa), FASTA scores: opt: 472, E(): 6.6e-28, (100.0% identity in 72 aa overlap). Also highly similar to others e.g. O54209|IF1_STRCO|INFA|SC6G4.03 from Streptomyces coelicolor (73 aa), FASTA scores: opt: 424, E(): 2e-24,(84.95% identity in 73 aa overlap); O50630|IF1_BACHD|INFA|BH0158 from Bacillus halodurans (71 aa), FASTA scores: opt: 388, E(): 8.1e-22, (77.8% identity in 72 aa overlap); Q9XD14|IF1_LEPIN|INFA from Leptospira interrogans (71 aa), FASTA scores: opt: 376, E(): 6e-21,(80.0% identity in 70 aa overlap); etc. CONTAINS 1 'S1 MOTIF' DOMAIN. BELONGS TO THE IF-1 FAMILY.	X2BND6,P0A5H6	No									X2BND6,P0A5H6	P0A5H6									
NC_002945.3	Mycobrowser_v4	CDS	3829533	3830528	.	+	0	Mb3493	rmlB1		dtdp-glucose 4,6-dehydratase rmlb	Mb3493, rmlB1, len: 331 aa. Equivalent to Rv3464,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 331 aa overlap). Probable rmlB1 (alternate gene name: rfbB), DTDP-glucose-4,6-dehydratase (EC 4.2.1.46), nearly identical to Q50556|RMLB rhamnose biosynthesis protein (EC 4.2.1.46) from Mycobacterium tuberculosis (329 aa) (previously rfbB, now known as rmlB). Equivalent to Q9CBH7|RMLB|ML1964 DTDP-GLUCOSE 4,6-DEHYDRATASE (alias Q9X7A3|RMLB PUTATIVE DTDP-(GLUCOSE OR RHAMNOSE)-4,6-DEHYDRATASE (331 aa)) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1925, E(): 1.9e-112,(84.0% identity in 331 aa overlap). Also highly similar to others e.g. Q9UZH2|RFBB|PAB0785 from Pyrococcus abyssi (333 aa), FASTA scores: opt: 1115, E(): 4.2e-62, (51.55% identity in 322 aa overlap); O27817|MTH1789 from Methanobacterium thermoautotrophicum (336 aa), FASTA scores: opt: 1104, E(): 2.1e-61, (51.65% identity in 331 aa overlap); BAB60064|TVG0950610 from Thermoplasma volcanium (318 aa), FASTA scores: opt: 1102, E(): 2.6e-61,(49.65% identity in 310 aa overlap); etc. Also related to P72050|MTCY13D12.18|RV3784 HYPOTHETICAL 36.3 KDA PROTEIN (SIMILAR TO GALACTOWALDENASES FROM EUKARYOTIC AND PROKARYOTIC ORIGIN) from Mycobacterium tuberculosis (326 aa), FASTA scores: E(): 1.4e-26, (33.8% identity in 320 aa overlap).	Q7TWG7	No								IPR001509,IPR005888,IPR016040	Q7TWG7	A0A1R3Y4A5									
NC_002945.3	Mycobrowser_v4	CDS	3830530	3831138	.	+	0	Mb3494	rmlC		dtdp-4-dehydrorhamnose 3,5-epimerase rmlc (dtdp-4-keto-6-deoxyglucose 3,5-epimerase) (dtdp-l-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase)	Mb3494, rmlC, len: 202 aa. Equivalent to Rv3465,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Probable rmlC (alternate gene name: rfbC), dtdp-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13), nearly identical to O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis (203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5% identity in 200 aa overlap) (previously known as rfbC). Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64,(75.4% identity in 199 aa overlap). Also highly similar to others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis (198 aa), FASTA scores: opt: 671, E(): 7e-38, (51.3% identity in 193 aa overlap); Q9L6C5 from Streptomyces antibioticus (202 aa), FASTA scores: opt: 665, E(): 1.8e-37, (49.25% identity in 197 aa overlap); P29783|STRM_STRGR from Streptomyces griseus (200 aa),FASTA scores: opt: 608, E(): 1.2e-33, (49.25% identity in 201 aa overlap); Q54265|STRM from Streptomyces glaucescens (200 aa), FASTA scores: opt: 603, E(): 2.5e-33, (46.7% identity in 197 aa overlap); etc. Also highly similar to Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE 3-EPIMERASE from Streptomyces fradiae (205 aa), FASTA scores: opt: 625,E(): 8.6e-35, (45.9% identity in 194 aa overlap).	Q7TWG6	No	intermediary metabolism and respiration							IPR000888,IPR011051,IPR014710	Q7TWG6	A0A1R3Y4B1				Rv3465		Rv3465			
NC_002945.3	Mycobrowser_v4	CDS	3834840	3836498	.	-	0	Mb3499c	ilvB2		PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB2 (AHAS) (ACETOHYDROXY-ACID SYNTHASE LARGE SUBUNIT) (ALS)	Mb3499c, ilvB2, len: 552 aa. Equivalent to Rv3470c,len: 552 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 552 aa overlap). Probable ilvB2,acetolactate synthase large subunit (EC 4.1.3.18), similar to others e.g. P73913|ILVG|SLR2088 from Synechocystis sp. strain PCC 6803 (621 aa), FASTA scores: opt: 779, E(): 4.5e-39, (30.7% identity in 567 aa overlap); O78518|ILVB_GUITH from Guillardia theta (Cryptomonas phi) (575 aa), FASTA scores: opt: 742, E(): 6.9e-37, (28.8% identity in 566 aa overlap); Q59950|ILVX from Spirulina platensis (612 aa), FASTA scores: opt: 715, E(): 3e-35,(28.45% identity in 569 aa overlap); etc. Contains thiamine pyrophosphate enzymes signature (PS00187).	Q7TWG1	No								IPR000399,IPR011766,IPR012000,IPR012001	Q7TWG1	A0A1R3Y484									
NC_002945.3	Mycobrowser_v4	CDS	3837644	3838429	.	-	0	Mb3502c	bpoA		POSSIBLE PEROXIDASE BPOA (NON-HAEM PEROXIDASE)	Mb3502c, bpoA, len: 261 aa. Equivalent to Rv3473c,len: 261 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 261 aa overlap). Possible bpoA,peroxidase (non-haem peroxidase) (EC 1.11.1.-), similar to various enzymes or hypothetical unknown proteins e.g. O85849 HYPOTHETICAL 26.2 KDA PROTEIN from Sphingomonas aromaticivorans (247 aa), FASTA scores: opt: 684, E(): 4.9e-34, (43.8% identity in 242 aa overlap); AAK45412|MT1155 HYDROLASE, ALPHA/BETA HYDROLASE FOLD FAMILY from Mycobacterium tuberculosis strain CDC1551 (311 aa), FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa overlap); Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from Streptomyces coelicolor (352 aa), FASTA scores: opt: 248, E(): 9.7e-08, (26.05% identity in 261 aa overlap); P29715|BPA2_STRAU|BPOA2 NON-HAEM BROMOPEROXIDASE (EC 1.11.1.-) (BROMIDE PEROXIDASE) (277 aa), FASTA scores: opt: 237, E(): 3.6e-07, (29.45% identity in 265 aa overlap); O31168|PRXC_STRAU|CPO|CPOT NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (278 aa), FASTA scores: opt: 236, E(): 4.2e-07, (29.45% identity in 265 aa overlap); AAK62388|T5L19.180 LIPASE-LIKE PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (350 aa), FASTA scores: opt: 236, E(): 5.1e-07, (26.65% identity in 274 aa overlap); etc. Also similar to O06575|BPOB|Rv1123c|MTCY22G8.12c HYPOTHETICAL 32.5 KDA PROTEIN from Mycobacterium tuberculosis (302 aa), FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa overlap). Equivalent to AAK47936 from Mycobacterium tuberculosis strain CDC1551 (294 aa) but shorter 33 aa. May have been inactivated or truncated by neighbouring IS6110.	Q7TWF8	No								IPR000639	Q7TWF8	A0A1R3Y491									
NC_002945.3	Mycobrowser_v4	CDS	3838709	3840058	.	-	0	Mb3503c	kgtP		PROBABLE DICARBOXYLIC ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN KGTP (DICARBOXYLATE TRANSPORTER)	Mb3503c, kgtP, len: 449 aa. Equivalent to Rv3476c,len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 449 aa overlap). Probable kgtP,dicarboxylate-transport integral membrane protein,possibly member of major facilitator superfamily (MFS),highly similar to others e.g. Q9HT43|PA5530 from Pseudomonas aeruginosa (435 aa), FASTA scores: opt: 1209,E(): 2.3e-68, (47.05% identity in 425 aa overlap); Q9I6Q9|PCAT|PA0229 from Pseudomonas aeruginosa (432 aa),FASTA scores: opt: 1131, E(): 1.8e-63, (40.4% identity in 438 aa overlap); Q9WWZ2 from Pseudomonas putida (429 aa),FASTA scores: opt: 1090, E(): 6.5e-61, (41.2% identity in 425 aa overlap); P17448|KGTP_ECOLI|WITA|B2587 from Escherichia coli strain K12 (432 aa), FASTA scores: opt: 1083, E(): 1.8e-60, (40.05% identity in 422 aa overlap); etc. Also similar to O05301|MTCI364.12|Rv1200 HYPOTHETICAL 44.6 KDA PROTEIN from Mycobacterium tuberculosis (425 aa),FASTA scores: E(): 5.2e-25, (28.5% identity in 382 aa overlap). Contains sugar transport protein signatures 1 and 2 (PS00216, PS00217). BELONG TO THE SUGAR TRANSPORTER FAMILY.	Q7TWF7	No								IPR005828,IPR005829,IPR016196,IPR020846	Q7TWF7	A0A1R3Y4B6									
NC_002945.3	Mycobrowser_v4	CDS	3840764	3841945	.	+	0	Mb3505	PPE60		pe family protein ppe60	Mb3505, PPE60, len: 393 aa. Equivalent to Rv3478,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). PPE60 (alternate gene name: mtb39c). Member of the M. tuberculosis PPE family,highly similar to others e.g. Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa),FASTA scores: opt: 2165, E(): 1.1e-109, (85.35% identity in 396 aa overlap); MTCI364.08; MTCY10G2.10; MTCY03A2.22c; MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc. Note that expression of Rv3478 was demonstrated in lysates by immunodetection (see citation below).	Q7TWF5	No								IPR000030,IPR022171	Q7TWF5	A0A1R3Y494									
NC_002945.3	Mycobrowser_v4	CDS	3860154	3861509	.	-	0	Mb3526c	mce4D		MCE-FAMILY PROTEIN MCE4D	Mb3526c, mce4D, len: 451 aa. Equivalent to Rv3496c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (531 aa), FASTA scores: opt: 837, E(): 2.6e-34, (34.55% identity in 446 aa overlap); Q9F359|SC8A2.04c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (337 aa), FASTA scores: opt: 606,E(): 4.9e-23, (32.35% identity in 300 aa overlap); etc. Hydrophobic region at N-terminus.	Q7TWD5	No								IPR003399,IPR005693,IPR024516	Q7TWD5	A0A1R3Y4A4									
NC_002945.3	Mycobrowser_v4	CDS	3848701	3850239	.	+	0	Mb3514	cpsA		POSSIBLE CONSERVED PROTEIN CPSA	Mb3514, cpsA, len: 512 aa. Equivalent to Rv3484,len: 512 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 512 aa overlap). Possible cpsA,hypothetical protein, equivalent to Q50160|CPSA|ML2247 HYPOTHETICAL PROTEIN CPSA from Mycobacterium leprae (516 aa), FASTA scores: opt: 2557, E(): 1.6e-143, (74.9% identity in 518 aa overlap); and with good similarity to Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FASTA scores: opt: 855, E(): 4.6e-43,(34.45% identity in 502 aa overlap). Also similar (or with similarity) to hypothetical proteins from Mycobacterium tuberculosis: P96872|Rv3267|MTCY71.07 (498 aa), FASTA scores: opt: 928, E(): 2.3e-47, (37.35% identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c (684 aa), FASTA scores: opt: 425, E(): 1.5e-17, (26.15% identity in 524 aa overlap). Shows also similarity with various bacterial proteins e.g. Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (507 aa), FASTA scores: opt: 329, E(): 5.3e-12, (28.85% identity in 478 aa overlap); Q9K4E6|2SC6G5.02 CONSERVED HYPOTHETICAL PROTEIN,POSSIBLE MEMBRANE PROTEIN, from Streptomyces coelicolor (382 aa), FASTA scores: opt: 305, E(): 1.1e-10, (29.8% identity in 386 aa overlap); O69850|SC1C3.08c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (366 aa), FASTA scores: opt: 304, E(): 1.2e-10, (29.6% identity in 395 aa overlap); Q9KZK3|SCE34.23 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (396 aa), FASTA scores: opt: 296, E(): 3.8e-10, (31.25% identity in 349 aa overlap); AAK43602|CPSA CPSA PROTEIN from Streptococcus agalactiae (485 aa), FASTA scores: opt: 250, E(): 2.4e-07, (30.25% identity in 162 aa overlap); etc.	Q7TWE7	No	conserved hypotheticals							IPR004474,IPR027381	Q7TWE7	A0A1R3Y4C8				Rv3484		Rv3484			
NC_002945.3	Mycobrowser_v4	CDS	3921274	3922713	.	+	0	Mb3569	PPE63		ppe family protein ppe63	Mb3569, PPE63, len: 479 aa. Equivalent to Rv3539,len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 479 aa overlap). Member of the Mycobacterium tuberculosis PPE protein family, similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa), FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa overlap); etc.	Q7TW93	No								IPR000030,IPR013228	Q7TW93	A0A1R3Y532									
NC_002945.3	Mycobrowser_v4	CDS	3851797	3852927	.	-	0	Mb3517c	lipF		PROBABLE ESTERASE/LIPASE LIPF	Mb3517c, lipF, len: 376 aa. Equivalent to esterase/lipase lipF from Mycobacterium bovis BCG strain Korea 1168P (100% identity with 375 aa overlap). 5' extension to annotation based on de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Probable lipF,esterase/lipase (EC 3.-.-.-), highly similar to O53424|LIPU|Rv1076|MTV017.29 PUTATIVE ESTERASE/LIPASE from Mycobacterium tuberculosis (297 aa), and similar to other putative lipases from Mycobacterium tuberculosis e.g. P71759|LIPK|RV2385|MTCY253.36c (306 aa). Equivalent to Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE (PUTATIVE ESTERASE) from Mycobacterium leprae (335 aa). Also similar to esterases and lipases of around 300 aa e.g. Q44087|EST ESTERASE PRECURSOR from Acinetobacter lwoffii (303 aa),P18773|EST_ACICA ESTERASE (EC 3.1.1.-) from Acinetobacter calcoaceticus (303 aa), Q9KIU1 ESTERASE from uncultured bacterium Plasmid pAH116 (308 aa),Q9X8J4|SCE9.22 PUTATIVE ESTERASE from Streptomyces coelicolor (266 aa), etc. Equivalent to AAK47950 from Mycobacterium tuberculosis strain CDC1551 (327 aa). UPDATE: Mb3517c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.	X2BNF2	No									X2BNF2	A0A1R3Y4B9									
NC_002945.3	Mycobrowser_v4	CDS	3853859	3855361	.	+	0	Mb3520	otsA		alpha, alpha-trehalose-phosphate synthase [udp-forming] otsa (trehalose-6-phosphate synthase) (udp-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-udp glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-udp glucosyl transferase)	Mb3520, otsA, len: 500 aa. Equivalent to Rv3490,len: 500 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 500 aa overlap). Probable otsA, alpha,alpha-trehalose-phosphate synthase (EC 2.4.1.15) (see citations below), equivalent to Q50167|OTSA|ML2254 PROBABLE TREHALOSE-PHOSPHATE SYNTHASE from Mycobacterium leprae (498 aa), FASTA scores: opt: 2706, E(): 1.6e-166,(80.3% identity in 497 aa overlap). Also similar to others e.g. Q92410|TPS1_CANAL from Candida albicans (Yeast) (478 aa), FASTA scores: opt: 895, E(): 4.9e-50, (37.15% identity in 479 aa overlap); Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YBR 0922 from Saccharomyces cerevisiae (Baker's yeast) (495 aa), FASTA scores: opt: 847, E(): 6.2e-47, (36.1% identity in 490 aa overlap); BAB48232|MLL0691 from Rhizobium loti (Mesorhizobium loti) (520 aa), FASTA scores: opt: 884,E(): 2.7e-49, (36.2% identity in 478 aa overlap); etc. Equivalent to AAK47953 from Mycobacterium tuberculosis strain CDC1551 (478 aa) but longer 22 aa.	X2BP60,Q7TWE1	No	virulence, detoxification, adaptation								X2BP60,Q7TWE1	Q7TWE1				Rv3490		Rv3490			
NC_002945.3	Mycobrowser_v4	CDS	3857298	3858992	.	-	0	Mb3524c	mce4F		MCE-FAMILY PROTEIN MCE4F	Mb3524c, mce4F, len: 564 aa. Equivalent to Rv3494c,len: 564 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 564 aa overlap). mce4F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to others e.g. Q9CD09|MCE1F|ML2594 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (516 aa), FASTA scores: opt: 1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap); Q9F361|SC8A2.02c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (433 aa), FASTA scores: opt: 570,E(): 3.7e-14, (30.8% identity in 458 aa overlap); etc. Has hydrophobic stretch, possibly a signal peptide at the N-terminus.	Q7TWD7	No								IPR003399,IPR005693	Q7TWD7	A0A1R3Y4D6									
NC_002945.3	Mycobrowser_v4	CDS	3865720	3866484	.	-	0	Mb3531c	yrbE4A		conserved integral membrane protein yrbe4a. possible abc transporter.	Mb3531c, yrbE4A, len: 254 aa. Equivalent to Rv3501c, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 254 aa overlap). yrbE4A,hypothetical unknown integral membrane protein, part of mce4 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa),FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in 247 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa), FASTA scores: opt: 313, E(): 3e-14,(25.7% identity in 241 aa overlap); etc.	Q7TWD0	No	virulence, detoxification, adaptation							IPR003453	Q7TWD0	A0A1R3Y4H4				Rv3501c		Rv3501c			
NC_002945.3	Mycobrowser_v4	CDS	3859003	3860157	.	-	0	Mb3525c	lprN		POSSIBLE MCE-FAMILY LIPOPROTEIN LPRN (MCE-FAMILY LIPOPROTEIN MCE4E)	Mb3525c, lprN, len: 384 aa. Equivalent to Rv3495c,len: 384 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 384 aa overlap). Possible lprN (alternate gene name: mce4E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); and O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also similar to others e.g. Q9F360|SC8A2.03c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (413 aa), FASTA scores: opt: 656, E(): 2.2e-32, (37.55% identity in 317 aa overlap); Q9CD10|LPRK|ML2593 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (392 aa), FASTA scores: opt: 616, E(): 5.5e-30,(28.95% identity in 373 aa overlap); etc. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TWD6	No								IPR003399,IPR005693	Q7TWD6	A0A1R3Y4E7									
NC_002945.3	Mycobrowser_v4	CDS	3867688	3867879	.	-	0	Mb3533c	fdxD		PROBABLE FERREDOXIN FDXD	Mb3533c, fdxD, len: 63 aa. Equivalent to Rv3503c,len: 63 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 63 aa overlap). Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 HYPOTHETICAL 9.3 KDA PROTEIN from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 DIOXYGENASE DITA FERREDOXIN COMPONENT from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoacetica (Clostridium thermoaceticum) (63 aa), FASTA scores: opt: 157, E(): 5.4e-05, (36.65% identity in 60 aa overlap); P18325|FER2_STRGO|SUBB from Streptomyces griseolus (64 aa) FASTA scores: opt: 157, E(): 5.5e-05, (39.35% identity in 61 aa overlap); etc. BELONGS TO THE BACTERIAL TYPE FERREDOXIN FAMILY.	Q7TWC8	No								IPR001080	Q7TWC8	A0A1R3Y4C2									
NC_002945.3	Mycobrowser_v4	CDS	3861506	3862579	.	-	0	Mb3527c	mce4C		MCE-FAMILY PROTEIN MCE4C	Mb3527c, mce4C, len: 357 aa. Equivalent to Rv3497c,len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 357 aa overlap). mce4C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to others e.g. Q9F358|SC8A2.05c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (351 aa), FASTA scores: opt: 658, E(): 1.1e-30, (33.95% identity in 318 aa overlap); Q9CD12|MCE1C|ML2591 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (519 aa), FASTA scores: opt: 555,E(): 1.2e-24, (28.35% identity in 328 aa overlap); etc. Hydrophobic region at N-terminus.	Q7TWD4	No								IPR003399,IPR005693,IPR008360	Q7TWD4	A0A1R3Y4C5									
NC_002945.3	Mycobrowser_v4	CDS	3862569	3863621	.	-	0	Mb3528c	mce4B		MCE-FAMILY PROTEIN MCE4B	Mb3528c, mce4B, len: 350 aa. Equivalent to Rv3498c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 350 aa overlap). mce4B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to others e.g. Q9CD13|MCE1B|ML2590 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (346 aa), FASTA scores: opt: 803, E(): 6.1e-41, (41.05% identity in 346 aa overlap); Q9F357|SC8A2.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (354 aa), FASTA scores: opt: 624,E(): 3.4e-30, (32.55% identity in 338 aa overlap); etc. Hydrophobic region at N-terminus.	Q7TWD3	No								IPR003399,IPR005693	Q7TWD3	A0A1R3Y606									
NC_002945.3	Mycobrowser_v4	CDS	3863621	3864823	.	-	0	Mb3529c	mce4A		MCE-FAMILY PROTEIN MCE4A	Mb3529c, mce4A, len: 400 aa. Equivalent to Rv3499c,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 400 aa overlap). mce4A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar to others e.g. Q9F356|SC8A2.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (418 aa), FASTA scores: opt: 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); Q9S4U5|MCE1 MYCOBACTERIAL CELL ENTRY PROTEIN from Mycobacterium bovis BCG (454 aa), FASTA scores: opt: 529,E(): 2.1e-24, (30.35% identity in 448 aa overlap); Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441 aa),FASTA scores: opt: 515, E(): 1.4e-23, (28.35% identity in 430 aa overlap); etc. Contains a possible N-terminal signal sequence. Note that previously known as mce4.	Q7TWD2	No								IPR003399,IPR005693,IPR024516	Q7TWD2	A0A1R3Y500									
NC_002945.3	Mycobrowser_v4	CDS	3864843	3865685	.	-	0	Mb3530c	yrbE4B		conserved integral membrane protein yrbe4b. possible abc transporter.	Mb3530c, yrbE4B, len: 280 aa. Equivalent to Rv3500c, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 280 aa overlap). yrbE4B,hypothetical unknown integral membrane protein, part of mce4 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa),FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in 269 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa), FASTA scores: opt: 270, E(): 6e-11,(25.4% identity in 264 aa overlap); etc.	Q7TWD1	No	virulence, detoxification, adaptation							IPR003453	Q7TWD1	A0A1R3Y4B5				Rv3500c		Rv3500c			
NC_002945.3	Mycobrowser_v4	CDS	3868094	3869296	.	+	0	Mb3534	fadE26		PROBABLE ACYL-COA DEHYDROGENASE FADE26	Mb3534, fadE26, len: 400 aa. Equivalent to Rv3504,len: 400 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 400 aa overlap). Probable fadE26,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other ACYL-COA DEHYDROGENASES from Mycobacterium tuberculosis e.g. P71858|FADE29|Rv3543c|MTCY03C7.13 (387 aa) FASTA scores: opt: 1031, E(): 7.5e-59, (46.25% identity in 402 aa overlap); and P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FASTA scores: opt: 617, E(): 3.1e-32, (32.6% identity in 423 aa overlap); etc. Also similar to others e.g. Q9A6G3|CC2131 from Caulobacter crescentus (403 aa) FASTA scores: opt: 710, E(): 3.2e-38, (33.4% identity in 413 aa overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 522, E(): 3.7e-26, (34.1% identity in 358 aa overlap); Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa), FASTA scores: opt: 509, E(): 2.6e-25,(34.45% identity in 363 aa overlap); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TWC7	No								IPR006091,IPR009075,IPR009100,IPR013786	Q7TWC7	A0A1R3Y4E9									
NC_002945.3	Mycobrowser_v4	CDS	3869321	3870442	.	+	0	Mb3535	fadE27		PROBABLE ACYL-COA DEHYDROGENASE FADE27	Mb3535, fadE27, len: 373 aa. Equivalent to Rv3505,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 373 aa overlap). Probable fadE27,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other ACYL-COA DEHYDROGENASES from Mycobacterium tuberculosis e.g. P71857|FADE28|Rv3544c|MTCY03C7.12 (339 aa) FASTA scores: opt: 497, E(): 1.8e-22, (30.3% identity in 343 aa overlap); and P95281|FADE18|Rv1933c|MTCY09F9.31 (363 aa) FASTA scores: opt: 421, E(): 6.4e-18, (32.35% identity in 334 aa overlap). Also similar to other e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 425, E(): 3.5e-18, (30.75% identity in 351 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa) FASTA scores: opt: 317, E(): 1e-11, (32.8% identity in 372 aa overlap); Q9L8Q3|PDTORFO from Pseudomonas stutzeri (Pseudomonas perfectomarina) (513 aa), FASTA scores: opt: 301, E(): 1.2e-10, (25.9% identity in 394 aa overlap); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TWC6	No								IPR006091,IPR009075,IPR009100,IPR013786	Q7TWC6	A0A1R3Y4F7									
NC_002945.3	Mycobrowser_v4	CDS	3870513	3872021	.	+	0	Mb3536	fadD17		fatty-acid-coa synthetase fadd17 (fatty-acid-coa synthase) (fatty-acid-coa ligase)	Mb3536, fadD17, len: 502 aa. Equivalent to Rv3506,len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 502 aa overlap). Possible fadD17,fatty-acid-CoA synthetase (ligase) (EC 6.2.1.-), similar to P72007|FADD1|RV1750c|MTCY28.13c|MTCY04C12.34 from Mycobacterium tuberculosis (532 aa), FASTA scores: opt: 666, E(): 9.8e-32, (52.05% identity in 488 aa overlap). Also similar to various ligases/synthetases e.g. Q9EY88|FCS FERULOYL-COA SYNTHETASE from Amycolatopsis sp. HR167 (491 aa), FASTA scores: opt: 490, E(): 2.1e-21,(30.3% identity in 462 aa overlap); BAB33463|ECS0040 (alias AAG54340|CAIC) PROBABLE CROTONOBETAINE/CARNITINE-COA LIGASE from Escherichia coli strain O157:H7 (522 aa), FASTA scores: opt: 478, E(): 1.1e-20, (28.5% identity in 347 aa overlap); Q9KHL1|ENCH PUTATIVE ACYL-COA LIGASE from Streptomyces maritimus (535 aa), FASTA scores: opt: 477, E(): 1.3e-20, (28.7% identity in 453 aa overlap); Q50017|XCLC|ML1051 ACYL-COA SYNTHASE from Mycobacterium leprae (476 aa), FASTA scores: opt: 472, E(): 2.3e-20, (31.35% identity in 469 aa overlap); P31552|CAIC_ECOLI|B0037 from Escherichia coli strain K12 (522 aa), FASTA scores: opt: 467, E(): 4.8e-20, (28.75% identity in 348 aa overlap); Q9KBC2|BH2006 from Bacillus halodurans LONG-CHAIN ACYL-COA SYNTHETASE (LIGASE) (513 aa), FASTA scores: opt: 462, E(): 9.4e-20, (27.65% identity in 463 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature.	X2BPR1,Q7TWC5	No									X2BPR1,Q7TWC5	Q7TWC5									
NC_002945.3	Mycobrowser_v4	CDS	3872192	3876274	.	+	0	Mb3537	PE_PGRS53		pe-pgrs family protein pe_pgrs53	Mb3537, PE_PGRS53, len: 1360 aa. Similar to Rv3507,len: 1381 aa, from Mycobacterium tuberculosis strain H37Rv, (93.635% identity in 1414 aa overlap). Member of the Mycobacterium tuberculosis PE protein family, PGRS subfamily of gly-rich proteins, similar to others from M. tuberculosis strains H37Rv and CDC1551 e.g. O06810|Rv1450c|MTCY493.04 (1329 aa), FASTA scores: opt: 2173, E(): 1.4e-135, (51.15% identity in 1412 aa overlap). Equivalent to AAK47970 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but with some minor differences between the proteins. Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 18 bp, 72 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 54 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa versus 1381 aa).	Q7TWC4	No								IPR000084	Q7TWC4	A0A1R3Y4D0									
NC_002945.3	Mycobrowser_v4	CDS	3876565	3880947	.	+	0	Mb3538	PE_PGRS54		pe-pgrs family protein pe_pgrs54	Mb3538, PE_PGRS54, len: 1460 aa. Similar to Rv3508,len: 1901 aa, from Mycobacterium tuberculosis strain H37Rv, (71.06% identity in 1904 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. downstream O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 6598, E(): 0, (71.05% identity in 1533 aa overlap). Equivalent to AAK47971 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but shorter 13 aa and with some minor differences between the proteins. Contains five PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,insertions of 9 bp (*-cggcgcggg), 27 bp and 18 bp,deletions of 168 bp, 603 bp and 48 bp, and several substitutions lead to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1460 aa versus 1901 aa).	Q7TWC3	No								IPR000084	Q7TWC3	A0A1R3Y615									
NC_002945.3	Mycobrowser_v4	CDS	3881114	3882661	.	-	0	Mb3539c	ilvX		PROBABLE ACETOHYDROXYACID SYNTHASE ILVX (ACETOLACTATE SYNTHASE)	Mb3539c, ilvX, len: 515 aa. Equivalent to Rv3509c,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 515 aa overlap). Probable ilvX,acetohydroxyacid synthase (EC 4.1.3.18), equivalent to Mycobacterium leprae protein described as Acetolactate synthase I, valine sensitive, large subunit (EC 4.1.3.18) Q49865|ILVX|ILVI1|B229_C3_222 (515 aa), FASTA scores: opt: 2762, E(): 8.8e-145, (82.9% identity in 515 aa overlap). Also similar to various enzymes (principally acetohydroxyacid/acetolactate synthases) e.g. Q9AB41|CC0393 THIAMINE-PYROPHOSPHATE-REQUIRING ENZYME from Caulobacter crescentus (512 aa), FASTA scores: opt: 1572,E(): 2.8e-79, (50.95% identity in 514 aa overlap); BAB50432|MLL3567 ACETOLACTATE SYNTHASE I from Rhizobium loti (Mesorhizobium loti) (517 aa), FASTA scores: opt: 1440, E(): 5.2e-72, (47.9% identity in 548 aa overlap); P20906|MDLC_PSEPU BENZOYLFORMATE DECARBOXYLASE (EC 4.1.1.7) from Pseudomonas putida (528 aa), FASTA scores: opt: 356, E(): 2.5e-12, (28.1% identity in 530 aa overlap); Q9L123|SC6D11.33c PUTATIVE DECARBOXYLASE from Streptomyces coelicolor (526 aa), FASTA scores: opt: 325,E(): 1.3e-10, (33.2% identity in 530 aa overlap); Q9RDF9|SCC57A.40c PUTATIVE ACETOLACTATE SYNTHASE from Streptomyces coelicolor (564 aa), FASTA scores: opt: 304,E(): 1.9e-09, (28.55% identity in 550 aa overlap); P94783 VALINE-SENSITIVE ACETOHYDROXY ACID SYNTHASE from Citrobacter freundii (561 aa), FASTA scores: opt: 278,E(): 5.1e-08, (25.8% identity in 550 aa overlap); Q42767|AHAS ACETOHYDROXYACID SYNTHASE (EC 4.1.3.18)from Gossypium hirsutum (Upland cotton) (659 aa), FASTA scores: opt: 278, E(): 5.8e-08, (26.15% identity in 558 aa overlap); etc. Note that other Mycobacterium tuberculosis proteins, e.g. O53250|MTV012.17c|ILVB_MYCTU|Rv3003c|MT3083|MTV012.17c,show better similarity to Acetolactate synthase I. SIMILAR TO OTHER ENZYMES WHICH REQUIRE TPP. COFACTOR: THIAMIN PYROPHOSPHATE (BY SIMILARITY).	Q7TWC2	No								IPR011766,IPR012001	Q7TWC2	A0A1R3Y507									
NC_002945.3	Mycobrowser_v4	CDS	3897541	3898122	.	-	0	Mb3547c	cyp142b		PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 CYP142B [SECOND PART]	Mb3547c, cyp142b, len: 193 aa. Equivalent to 3' end of Rv3518c, len: 398 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 193 aa overlap). Probable cyp142, cytochrome P450 monoxygenase (EC 1.14.-.-), member of Cytochrome P450 family and similar to many e.g. Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 aa overlap); P33271|CPXK_SACER|CYP107B1 from Saccharopolyspora erythraea (Streptomyces erythraeus) (405 aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also similar to Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa overlap). Equivalent to AAK47979 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but longer 26 aa. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b.	Q7TWB4	No								IPR001128,IPR002397,IPR017972	Q7TWB4	A0A1R3Y4F0									
NC_002945.3	Mycobrowser_v4	CDS	3889799	3890455	.	-	0	Mb3542c	fadD18		PROBABLE FATTY-ACID-COA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb3542c, fadD18, len: 218 aa. Equivalent to Rv3513c, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 218 aa overlap). Probable fadD18, fatty-acid-CoA synthetase (C-terminal fragment) (EC 6.2.1.-), almost identical to C-terminal end of downstream O53560|FADD19|Rv3515c|MTV023.22c, probably result of partial gene duplication. Also similar at the C-terminus to other fatty-acid-CoA synthetases e.g. Q9EXL2|FADD from Streptomyces griseus (540 aa), FASTA scores: opt: 586, E(): 1.2e-28, (52.45% identity in 185 aa overlap); AAB87139|MIG MEDIUM CHAIN ACYL-COA SYNTHETASE PRECURSOR from Mycobacterium avium (550 aa), FASTA scores: opt: 506, E(): 9.5e-24, (50.0% identity in 150 aa overlap); Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--COA LIGASE from Caulobacter crescentus (561 aa), FASTA scores: opt: 430, E(): 4.4e-19, (45.75% identity in 153 aa overlap); Q9KDT0|BH1131 ACID-COA LIGASE from Bacillus halodurans (546 aa), FASTA scores: opt: 338, E(): 1.9e-13, (38.05% identity in 142 aa overlap); Q9RTR4|DR1692 LONG-CHAIN FATTY ACID--COA LIGASE from Deinococcus radiodurans (584 aa), FASTA scores: opt: 331, E(): 5.3e-13, (35.15% identity in 145 aa overlap); etc. Start uncertain.	Q7TWB9	No	lipid metabolism							IPR025110	Q7TWB9	A0A1R3Y4G0				Rv3513c		Rv3513c			
NC_002945.3	Mycobrowser_v4	CDS	3890501	3893479	.	+	0	Mb3543	PE_PGRS57		pe-pgrs family protein pe_pgrs57	Mb3543, PE_PGRS57, len: 992 aa. Similar to Rv3514,len: 1489 aa, from Mycobacterium tuberculosis strain H37Rv, (80.6% identity in 1133 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47971 (1715 aa) FASTA scores: opt: 6940, E(): 0, (67.0% identity in 1713 aa overlap); and upstream O53553|YZ08_MYCTU|Rv3508|MTV023.15 (1901 aa), FASTA scores: opt: 6598,E(): 0, (71.05% identity in 1533 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 9 bp (*-gcgggcggc) and 285 bp, and deletions of 240 bp, 951 bp and 609 bp, lead to shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (992 aa versus 1489 aa).	Q7TWB8	No								IPR000084	Q7TWB8	A0A1R3Y4C9									
NC_002945.3	Mycobrowser_v4	CDS	3894040	3895686	.	-	0	Mb3544c	fadD19		fatty-acid-coa ligase fadd19 (fatty-acid-coa synthetase) (fatty-acid-coa synthase)	Mb3544c, fadD19, len: 548 aa. Equivalent to Rv3515c, len: 548 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 548 aa overlap). Probable fadD19, fatty-acid-CoA synthetase (EC 6.2.1.-),similar (or with similarity) to many e.g. Q9EXL2|FADD FADD PROTEIN from Streptomyces griseus (540 aa), FASTA scores: opt: 1449, E(): 1.5e-81, (46.0% identity in 535 aa overlap); AAB87139|MIG MEDIUM CHAIN ACYL-COA SYNTHETASE PRECURSOR from Mycobacterium avium (550 aa), FASTA scores: opt: 1226, E(): 7.6e-68, (40.7% identity in 543 aa overlap); Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--COA LIGASE from Caulobacter crescentus (561 aa), FASTA scores: opt: 979, E(): 1.2e-52, (34.05% identity in 531 aa overlap); O28502|AF1772 LONG-CHAIN-FATTY-ACID--COA LIGASE (FADD-7) from Archaeoglobus fulgidus (569 aa), FASTA scores: opt: 560, E(): 6.9e-27, (29.3% identity in 543 aa overlap); Q9A8N2|CC1321 LONG-CHAIN-FATTY-ACID--COA LIGASE from Caulobacter crescentus (583 aa), FASTA scores: opt: 544,E(): 6.7e-26, (27.2% identity in 518 aa overlap); P29212|LCFA_ECOLI|FADD|OLDD|B1805 LONG-CHAIN-FATTY-ACID--COA LIGASE from Escherichia coli strain K12 (561 aa), FASTA scores: opt: 460, E(): 4e-22,(26.3% identity in 567 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. Note that upstream MTV023.20c|Rv3513c|fadD18 is identical to C-terminal part of FADD19|Rv3515c|MTV023.22c (probably result of partial gene duplication).	X2BNN2,Q7TWB7	No	lipid metabolism								X2BNN2,Q7TWB7	Q7TWB7				Rv3515c		Rv3515c			
NC_002945.3	Mycobrowser_v4	CDS	3895760	3896551	.	+	0	Mb3545	echA19		POSSIBLE ENOYL-COA HYDRATASE ECHA19 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb3545, echA19, len: 263 aa. Equivalent to Rv3516,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Possible echA19,enoyl-CoA hydratase (EC 4.2.1.17), similar to other e.g. Q9ZHG2|ECHA1 from Rhodococcus fascians (275 aa) FASTA scores: opt: 613, E(): 6.4e-32, (45.15% identity in 259 aa overlap); P76082|PAAF_ECOLI|B1393 from Escherichia coli strain K12 (255 aa), FASTA scores: opt: 523, E(): 3.3e-26,(33.6% identity in 256 aa overlap); Q9I393|PA1629 from Pseudomonas aeruginosa (261 aa), FASTA scores: opt: 475,E(): 3.8e-23, (36.85% identity in 247 aa overlap); etc. Also similar to many carnitine racemases eg BAB52369|MLL6015 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 546, E(): 1.1e-27, (36.65% identity in 251 aa overlap). Similar to several putative enoyl-CoA hydratases from Mycobacterium tuberculosis, e.g. P96404|ECHA1|Rv0222|MTCY08D5.17 (262 aa), FASTA scores: opt: 630, E(): 5.1e-33, (44.5% identity in 254 aa overlap); and O53783|ECHA5|Rv0675|MTV040.03 (263 aa) FASTA scores: opt: 499, E(): 1.1e-24, (40.5% identity in 252 aa overlap). COULD BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY.	Q7TWB6	No								IPR001753	Q7TWB6	A0A1R3Y4G3									
NC_002945.3	Mycobrowser_v4	CDS	4031177	4031890	.	+	0	Mb3677	PE_PGRS61		pe-pgrs family-related protein pe_pgrs61	Mb3677, PE_PGRS61, len: 237 aa. Similar to Rv3653,len: 195 aa, from Mycobacterium tuberculosis strain H37Rv,(82.2% identity in 237 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to the C-termini of members of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, e.g. MTCY1A11_25,MTCY28_25, MTCY130_10, MTCY1A10_19, MTCY21B4_13,MTCI418B_6,MTCY28_34, MTV004_1, MTCY441_4; etc. Originally annotated as the second part of a PE-PGRS family protein (Rv3652/PE_PGRS60 being the first part). Start shortened since first submission (-50 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium tuberculosis strain H37Rv, (237 aa versus 195 aa).	Q7TW10	No									Q7TW10	A0A1R3Y6C9									
NC_002945.3	Mycobrowser_v4	CDS	3898119	3898736	.	-	0	Mb3548c	cyp142a		PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 CYP142A [FIRST PART]	Mb3548c, cyp142a, len: 205 aa. Equivalent to 5' end of Rv3518c, len: 398 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 197 aa overlap). Probable cyp142, cytochrome P450 monoxygenase (EC 1.14.-.-), member of Cytochrome P450 family and similar to many e.g. Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 aa overlap); P33271|CPXK_SACER|CYP107B1 from Saccharopolyspora erythraea (Streptomyces erythraeus) (405 aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also similar to Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa overlap). Equivalent to AAK47979 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but longer 26 aa. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b.	Q7TWB3	No								IPR001128,IPR002397	Q7TWB3	A0A1R3Y628									
NC_002945.3	Mycobrowser_v4	CDS	3901663	3902727	.	+	0	Mb3552	ltp4		possible lipid transfer protein or keto acyl-coa thiolase ltp4	Mb3552, -, len: 354 aa. Equivalent to Rv3522, len: 354 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 354 aa overlap). Possible lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to several e.g. O30103|AF0134 3-KETOACYL-COA THIOLASE (ACAB-4) from Archaeoglobus fulgidus (398 aa) FASTA scores: opt: 352, E(): 5.3e-15, (30.45% identity in 381 aa overlap); O29295|AF0967 3-KETOACYL-COA THIOLASE (ACAB-9) from Archaeoglobus fulgidus (400 aa) FASTA scores: opt: 312, E(): 1.8e-12, (28.05% identity in 367 aa overlap); O29294|AF0968 3-KETOACYL-COA THIOLASE (ACAB-10) from Archaeoglobus fulgidus (388 aa), FASTA scores: opt: 293,E(): 2.9e-11, (25.9% identity in 309 aa overlap); O58409|PH0676 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN (ACETHYL CoA SYNTHETASE) (EC 6.2.1.-) from Pyrococcus horikoshii (389 aa), FASTA scores: opt: 292,E(): 3.3e-11, (25.8% identity in 368 aa overlap); Q9Y9A3|APE2382 LONG HYPOTHETICAL NON SPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (360 aa) FASTA scores: opt: 270, E(): 7.8e-10, (27.25% identity in 363 aa overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (400 aa), FASTA scores: opt: 258, E(): 4.9e-09, (26.45% identity in 306 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TWA9	No	lipid metabolism							IPR002155,IPR016038,IPR016039	Q7TWA9	A0A1R3Y4H2				Rv3522		Rv3522			
NC_002945.3	Mycobrowser_v4	CDS	3902744	3903928	.	+	0	Mb3553	ltp3		probable lipid carrier protein or keto acyl-coa thiolase ltp3	Mb3553, -, len: 394 aa. Equivalent to Rv3523, len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 394 aa overlap). Probable lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16),similar to several e.g. O30037|AF0202 3-KETOACYL-COA THIOLASE (ACAB-6) from Archaeoglobus fulgidus (380 aa) FASTA scores: opt: 782, E(): 1.7e-40, (38.35% identity in 386 aa overlap); Q9Y9A1|APE2384 LONG HYPOTHETICAL NON SPECIFIC LIPID-TRANSFER PROTEIN (ACETHYL CoA SYNTHETASE) (EC 6.2.1.-) from Aeropyrum pernix (394 aa), FASTA scores: opt: 626, E(): 5.9e-31, (35.75% identity in 386 aa overlap); BAB59210|TVG0067506 LIPID TRANSFER PROTEIN from Thermoplasma volcanium (390 aa), FASTA scores: opt: 591,E(): 8.1e-29, (34.35% identity in 384 aa overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (400 aa) FASTA scores: opt: 588, E(): 1.3e-28, (31.6% identity in 408 aa overlap); O30104|AF0133 3-KETOACYL-COA THIOLASE (ACAB-3) from Archaeoglobus fulgidus (411 aa) FASTA scores: opt: 583, E(): 2.6e-28, (39.8% identity in 412 aa overlap); O29811|AF0438 3-KETOACYL-COA THIOLASE (ACAB-8) from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 574, E(): 8.8e-28, (30.95% identity in 388 aa overlap); etc.	Q7TWA8	No	lipid metabolism							IPR002155,IPR016038,IPR016039	Q7TWA8	A0A1R3Y4D8				Rv3523		Rv3523			
NC_002945.3	Mycobrowser_v4	CDS	4311909	4314410	.	-	0	Mb3924c	eccc2		POSSIBLE CONSERVED MEMBRANE PROTEIN [FIRST PART]	Mb3924c, -, len: 833 aa. Equivalent to 5' end of Rv3894c, len: 1396 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 771 aa overlap). Possible conserved membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa),FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 537,E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 523, E(): 8.6e-23, (31.65% identity in 1412 aa overlap). Also similar to various proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 973, E(): 2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23,(24.95% identity in 1450 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),FASTA scores: opt: 444, E(): 4.1e-18, (22.5% identity in 1346 aa overlap); etc. Also similar to AAK46103|MT1833 FTSK/SPOIIIE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt: 769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap); and other hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391 aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa overlap) (similarity only with C-terminal end); etc. Contains two possible (PS00017) ATP/GTP-binding sites (P-loop) in central portion. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts, Mb3923c and Mb3924c.	Q7TVE6	No								IPR002543,IPR023836,IPR027417	Q7TVE6	A0A1R3Y5T2									
NC_002945.3	Mycobrowser_v4	CDS	3915767	3916807	.	-	0	Mb3564c	hsaf		PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA)	Mb3564c, -, len: 346 aa. Equivalent to Rv3534c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Probable 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), highly similar to others e.g. P51015|BPHI_PSESP from Pseudomonas sp. strain LB400 (346 aa), FASTA scores: opt: 1150, E(): 2.3e-61, (51.35% identity in 331 aa overlap); Q52040|BPHX3 from Pseudomonas pseudoalcaligenes (346 aa), FASTA scores: opt: 1147, E(): 3.5e-61, (51.35% identity in 331 aa overlap); P51017|NAHM_PSEPU from Pseudomonas putida (346 aa), FASTA scores: opt: 1145, E(): 4.7e-61, (50.9% identity in 330 aa overlap) (see citation below); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 1133, E(): 2.4e-60,(52.0% identity in 327 aa overlap); O24833|ATDG from Acinetobacter sp (340 aa), FASTA scores: opt: 1132, E(): 2.7e-60, (50.45% identity in 331 aa overlap); etc. Note that also highly similar to Q9ZI56|NAHM 2-OXO-4-HYDROXYPENTANOATE ALDOLASE from Pseudomonas stutzeri (Pseudomonas perfectomarina) (346 aa) FASTA scores: opt: 1168, E(): 2e-62, (51.05% identity in 331 aa overlap) (see citation below).	X2BNP9,Q7TW97	No	intermediary metabolism and respiration								X2BNP9,Q7TW97	Q7TW97				Rv3534c		Rv3534c			
NC_002945.3	Mycobrowser_v4	CDS	3905654	3906814	.	+	0	Mb3556	ksha		oxygenase component of 3-ketosteroid-9-alpha-hydroxylase ksha	Mb3556, -, len: 386 aa. Equivalent to Rv3526, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Hypothetical oxidoreductase (EC 1.-.-.-), highly similar, except in C-terminus (also longer 69 aa), to O69348|ORF12 PROTEIN (function unknown) from Rhodococcus erythropolis (316 aa) FASTA scores: opt: 1137, E(): 6.9e-65, (59.6% identity in 250 aa overlap). Also some similarity with several aminopyrrolnitrin oxidases (PRND proteins, involved in the pathway for pyrrolnitrin biosynthesis, a secondary metabolite derived from tryptophan which has strong anti-fungal activity) e.g. Q9RPG0|PRND from Myxococcus fulvus (379 aa), FASTA scores: opt: 322, E(): 4.4e-13,(25.85% identity in 352 aa overlap); Q9RPG4|PRND from Burkholderia cepacia (Pseudomonas cepacia) (373 aa) FASTA scores: opt: 306, E(): 4.5e-12, (25.2% identity in 373 aa overlap); P95483|PRND from Pseudomonas fluorescens (363 aa), FASTA scores: opt: 305, E(): 5.1e-12, (25.0% identity in 372 aa overlap); etc. And also some similarity to other putative enzymes like dioxygenases, oxidases, vanillate O-demethyl oxygenase, etc.	Q7TWA5	No	intermediary metabolism and respiration							IPR017941	Q7TWA5	A0A1R3Y4D7				Rv3526		Rv3526			
NC_002945.3	Mycobrowser_v4	CDS	3918584	3920275	.	+	0	Mb3567	kstd		PROBABLE DEHYDROGENASE	Mb3567, -, len: 563 aa. Equivalent to Rv3537, len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 563 aa overlap). Probable dehydrogenase (EC 1.-.-.-), similar to many dehydrogenases or hypothetical proteins e.g. Q9I1M6|PA2243 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (577 aa), FASTA scores: opt: 984, E(): 1.2e-48, (34.75% identity in 573 aa overlap); Q06401|3O1D_COMTE 3-OXOSTEROID 1-DEHYDROGENASE from Comamonas testosteroni (Pseudomonas testosteroni) (573 aa), FASTA scores: opt: 955, E(): 5.5e-47, (33.05% identity in 590 aa overlap); Q9RA02|KSTD1 3-KETOSTEROID DEHYDROGENASE from Rhodococcus erythropolis (510 aa),FASTA scores: opt: 631, E(): 1.4e-28, (39.15% identity in 557 aa overlap); P77815|KSDD 3-KETOSTEROID-1-DEHYDROGENASE from Nocardioides simplex (Arthrobacter simplex) (515 aa),FASTA scores: opt: 469, E(): 2.4e-19, (35.45% identity in 564 aa overlap); etc.	Q7TW95	No	intermediary metabolism and respiration							IPR003953,IPR027477	Q7TW95	A0A1R3Y4G9				Rv3537		Rv3537			
NC_002945.3	Mycobrowser_v4	CDS	3912558	3913778	.	+	0	Mb3562	PPE61		ppe family protein ppe61	Mb3562, PPE61, len: 406 aa. Equivalent to Rv3532,len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Member of the Mycobacterium tuberculosis PPE protein family, similar to many, e.g. O53956|Rv1807|MTV049.29 (403 aa), FASTA scores: opt: 954, E(): 1.1e-43, (44.1% identity in 417 aa overlap)	Q7TW99	No								IPR000030,IPR022171	Q7TW99	A0A1R3Y4I7									
NC_002945.3	Mycobrowser_v4	CDS	3913920	3915668	.	-	0	Mb3563c	PPE62		ppe family protein ppe62	Mb3563c, PPE62, len: 582 aa. Equivalent to Rv3533c,len: 582 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 582 aa overlap). Member of the Mycobacterium tuberculosis PPE protein family, similar to many, e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: opt: 2289, E(): 2.3e-95, (63.5% identity in 600 aa overlap).	Q7TW98	No								IPR000030,IPR002989	Q7TW98	A0A1R3Y4F2									
NC_002945.3	Mycobrowser_v4	CDS	3916804	3917715	.	-	0	Mb3565c	hsag		PROBABLE ACETALDEHYDE DEHYDROGENASE (ACETALDEHYDE DEHYDROGENASE [ACETYLATING])	Mb3565c, -, len: 303 aa. Equivalent to Rv3535c,len: 303 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 303 aa overlap). Probable acetaldehyde dehydrogenase (EC 1.2.1.10), highly similar to many e.g. BAB62056|TDNI from Pseudomonas putida (302 aa), FASTA scores: opt: 1159, E(): 1.5e-62, (60.45% identity in 301 aa overlap); Q9ZI57|NAHO from Pseudomonas stutzeri (Pseudomonas perfectomarina) (307 aa) FASTA scores: opt: 1151, E(): 4.6e-62, (59.55% identity in 299 aa overlap); Q9F9I4|CDOI from Comamonas sp. JS765 (302 aa) FASTA scores: opt: 1136, E(): 3.6e-61, (60.15% identity in 301 aa overlap); Q51962|NAHO from Pseudomonas putida (307 aa),FASTA scores: opt: 1133, E(): 5.6e-61, (58.55% identity in 299 aa overlap) (see citation below); P77580|MHPF_ECOLI|MHPF|MHPE|B0351 from Escherichia coli strain K12 (316 aa), FASTA scores: opt: 1040, E(): 2.2e-55, (56.85% identity in 306 aa overlap); etc.	X2BP90,Q7TTR4	No	intermediary metabolism and respiration								X2BP90,Q7TTR4	Q7TTR4				Rv3535c		Rv3535c			
NC_002945.3	Mycobrowser_v4	CDS	3953411	3954286	.	-	0	Mb3600c	hsad		4,9-dhsa hydrolase	Mb3600c, bphD, len: 291 aa. Equivalent to Rv3569c,len: 291 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 291 aa overlap). Probable bphD,2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (EC 3.7.1.-), highly similar to others e.g. Q9KWQ6|BPHD2 from Rhodococcus sp. RHA1 (292 aa), FASTA scores: opt: 1468,E(): 1.3e-85, (75.5% identity in 294 aa overlap); Q52036 from Pseudomonas putida (286 aa), FASTA scores: opt: 785,E(): 1.9e-42, (45.1% identity in 295 aa overlap); Q52011|BPHD from Pseudomonas pseudoalcaligenes (286 aa),FASTA scores: opt: 774, E(): 9.3e-42, (44.05% identity in 295 aa overlap); P47229|BPHD_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (286 aa) FASTA scores: opt: 772, E(): 1.2e-41, (44.5% identity in 295 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A. SIMILAR TO ALPHA/BETA HYDROLASE FOLD.	Q7TW65	No								IPR000073	Q7TW65	A0A1R3Y4I4									
NC_002945.3	Mycobrowser_v4	CDS	3922714	3923874	.	-	0	Mb3570c	ltp2		probable lipid transfer protein or keto acyl-coa thiolase ltp2	Mb3570c, ltp2, len: 386 aa. Equivalent to Rv3540c,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Probable ltp2,lipid-transfer protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to several e.g. Q9X4X2|DITF DITF PROTEIN (hypothetical protein, similar to non-specific lipid-transfer protein and 3-ketoacyl-CoA thiolase) from Pseudomonas abietaniphila (397 aa), FASTA scores: opt: 665, E(): 5.3e-34, (33.4% identity in 392 aa overlap); O30255|AF2416 3-KETOACYL-COA THIOLASE (ACAB-12) from Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 496,E(): 1.6e-23, (30.35% identity in 389 aa overlap); O28978|AF1291 3-KETOACYL-COA THIOLASE (ACAB-11) from Archaeoglobus fulgidus (392 aa), FASTA scores: opt: 494,E(): 2.2e-23, (30.6% identity in 379 aa overlap); O26884|MTH793 LIPID-TRANSFER PROTEIN (STEROL OR NONSPECIFIC) from Methanobacterium thermoautotrophicum (383 aa), FASTA scores: opt: 487, E(): 5.9e-23, (30.4% identity in 388 aa overlap); etc.	Q7TW92	No								IPR002155,IPR016038,IPR016039	Q7TW92	A0A1R3Y4F4									
NC_002945.3	Mycobrowser_v4	CDS	3925192	3926355	.	-	0	Mb3573c	fadE29		PROBABLE ACYL-COA DEHYDROGENASE FADE29	Mb3573c, fadE29, len: 387 aa. Equivalent to Rv3543c, len: 387 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 387 aa overlap). Probable fadE29, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. Q9A8P3|CC1310 from Caulobacter crescentus (404 aa), FASTA scores: opt: 624, E(): 9.4e-32,(32.75% identity in 400 aa overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 550,E(): 3.9e-27, (33.7% identity in 350 aa overlap); O28976|AF1293 from Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 529, E(): 8.1e-26, (30.0% identity in 393 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. O53549|FADE26|Rv3504|MTV023.11 (400 aa),FASTA scores: opt: 1031, E(): 2.8e-57, (46.0% identity in 402 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TW89	No	lipid metabolism							IPR006091,IPR009075,IPR009100,IPR013786	Q7TW89	A0A1R3Y4F9				Rv3543c		Rv3543c			
NC_002945.3	Mycobrowser_v4	CDS	3926340	3927359	.	-	0	Mb3574c	fadE28		PROBABLE ACYL-COA DEHYDROGENASE FADE28	Mb3574c, fadE28, len: 339 aa. Equivalent to Rv3544c, len: 339 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 339 aa overlap). Probable fadE28, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 334, E(): 5.1e-13,(27.65% identity in 329 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 278,E(): 1.2e-09, (26.95% identity in 319 aa overlap); O29813|AF0436 from Archaeoglobus fulgidus (382 aa) FASTA scores: opt: 205, E(): 3.5e-05, (24.75% identity in 384 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. O53550|FADE27|Rv3505|MTV023.12 (373 aa) FASTA scores: opt: 497, E(): 7e-23, (30.3% identity in 343 aa overlap); and to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE ACYL-COA DEHYDROGENASE from Mycobacterium leprae (389 aa) FASTA scores: opt: 165, E(): 0.0012, (25.2% identity in 345 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TW88	No	lipid metabolism							IPR009075,IPR009100,IPR013786	Q7TW88	A0A1R3Y4H3				Rv3544c		Rv3544c			
NC_002945.3	Mycobrowser_v4	CDS	3927359	3928660	.	-	0	Mb3575c	cyp125		PROBABLE CYTOCHROME P450 125 CYP125	Mb3575c, cyp125, len: 433 aa. Equivalent to Rv3545c, len: 433 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 433 aa overlap). Probable cyp125, cytochrome P-450 (EC 1.14.-.-), similar to others e.g. Q59723|LINC|CYP111 from Pseudomonas incognita (406 aa), FASTA scores: opt: 831, E(): 8e-45,(34.75% identity in 406 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 694, E(): 3.3e-36, (32.35% identity in 417 aa overlap); Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 664, E(): 2.5e-34, (34.15% identity in 413 aa overlap); O08469|CPXY_BACSU|CYPA|CYP107J1 from Bacillus subtilis (410 aa), FASTA scores: opt: 579, E(): 5.6e-29, (30.05% identity in 366 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA scores: opt: 1040, E(): 6.1e-58, (40.75% identity in 432 aa overlap). BELONGS TO THE CYTOCHROME P450 FAMILY.	X2BP97,P63710	No	intermediary metabolism and respiration								X2BP97,P63710	P63710				Rv3545c		Rv3545c			
NC_002945.3	Mycobrowser_v4	CDS	3928772	3929947	.	+	0	Mb3576	fadA5		PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA5 (ACETOACETYL-COA THIOLASE)	Mb3576, fadA5, len: 391 aa. Equivalent to Rv3546,len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 391 aa overlap). Probable fadA5,acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many e.g. Q9AA29|CC0779 from Caulobacter crescentus (390 aa),FASTA scores: opt: 999, E(): 7.1e-54, (43.5% identity in 400 aa overlap); Q9K783|BH3487 from Bacillus halodurans (393 aa), FASTA scores: opt: 843, E(): 2.6e-44, (37.45% identity in 398 aa overlap); Q9RRK9|DR2480 from Deinococcus radiodurans (399 aa), FASTA scores: opt: 826,E(): 2.8e-43, (38.15% identity in 396 aa overlap); P45369|THIL_CHRVI|PHBA from Chromatium vinosum (394 aa) FASTA scores: opt: 790, E(): 4.5e-41, (39.4% identity in 401 aa overlap); etc. Contains PS00737 Thiolases signature 2. BELONGS TO THE THIOLASE FAMILY.	Q7TW87	No								IPR002155,IPR016038,IPR016039,IPR020613,IPR020616,IPR020617	Q7TW87	A0A1R3Y4F3									
NC_002945.3	Mycobrowser_v4	CDS	3993842	3996124	.	-	0	Mb3640c	ftsH		MEMBRANE-BOUND PROTEASE FTSH (CELL DIVISION PROTEIN)	Mb3640c, ftsH, len: 760 aa. Equivalent to Rv3610c,len: 760 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 760 aa overlap). ftsH, membrane-bound protease (cell division protein) (EC 3.4.24.-) (see citation below), equivalent to Q9CD58|FTSH_MYCLE|ML0222 (alias O69532|FTSH) CELL DIVISION PROTEIN FTSH HOMOLOG from Mycobacterium leprae (787 aa), FASTA scores: opt: 4388, E(): 9.6e-205, (87.2% identity in 790 aa overlap). Also highly similar to many FTSH proteins e.g. O52395|FTSH from Mycobacterium smegmatis (769 aa), FASTA scores: opt: 3976, E(): 7.6e-185, (82.4% identity in 761 aa overlap); Q9X8I4|SCE9.11c from Streptomyces coelicolor (668 aa),FASTA scores: opt: 2417, E(): 1.4e-109, (57.2% identity in 668 aa overlap); P72991|FTH4_SYNY3|SLR1604 from Synechocystis sp. strain PCC 6803 (616 aa), FASTA scores: opt: 1926, E(): 7.2e-86, (49.35% identity in 612 aa overlap); P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from Escherichia coli strain K12 (644 aa), FASTA scores: opt: 1859, E(): 1.3e-82, (48.95% identity in 605 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature. BELONGS TO THE AAA FAMILY OF ATPASES AND PEPTIDASE FAMILY M41 (ZINC METALLOPROTEASE). COFACTOR: BINDS ONE ZINC ION (POTENTIAL).	X2BPW9,P0A4V9	No									X2BPW9,P0A4V9	P0A4V9									
NC_002945.3	Mycobrowser_v4	CDS	3973086	3973709	.	-	0	Mb3619c	canb		beta-carbonic anhydrase canb	Mb3619c, -, len: 207 aa. Equivalent to Rv3588c,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 207 aa overlap). Probable carbonic anhydrase (EC 4.2.1.1), equivalent to Q9CBJ1|ML1919 PUTATIVE CARBONIC ANHYDRASE from Mycobacterium leprae (213 aa), FASTA scores: opt: 1160, E(): 3.1e-66, (84.55% identity in 207 aa overlap). Also similar to many e.g. Q9X903|SCH35.03 from Streptomyces coelicolor (207 aa),FASTA scores: opt: 689, E(): 1.6e-36, (53.85% identity in 195 aa overlap); Q9RS89|DR2238 from Deinococcus radiodurans (264 aa), FASTA scores: opt: 451, E(): 2e-21,(39.7% identity in 189 aa overlap); Q39589|BETA-CA1 from Chlamydomonas reinhardtii (267 aa) FASTA scores: opt: 419,E(): 2.1e-19, (36.55% identity in 197 aa overlap); etc. Contains PS00704 and PS00705 Prokaryotic-type carbonic anhydrases signature 1 and 2. BELONGS TO THE PLANT AND PROKARYOTIC CARBONIC ANHYDRASE FAMILY.	Q7TW50	No	intermediary metabolism and respiration							IPR001765,IPR015892	Q7TW50	A0A1R3Y564				Rv3588c		Rv3588c			
NC_002945.3	Mycobrowser_v4	CDS	3930059	3930514	.	+	0	Mb3577	ddn		deazaflavin-dependent nitroreductase ddn	Mb3577, -, len: 151 aa. Equivalent to Rv3547, len: 151 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 151 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins e.g. O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa), FASTA scores: opt: 353, E(): 6.3e-17, (42.55% identity in 134 aa overlap); Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa) FASTA scores: opt: 290, E(): 2.1e-12, (38.5% identity in 122 aa overlap) (similarity in N-terminus for this protein); BAB52932|Q988L5|MLL6688 from Rhizobium loti (Mesorhizobium loti) (148 aa), FASTA scores: opt: 105,E(): 3, (26.75% identity in 86 aa overlap). Also similar to mycobacterial hypothetical proteins e.g. Q9ZH81 from M. paratuberculosis (144 aa), FASTA scores: opt: 366, E(): 8.2e-18, (43.9% identity in 123 aa overlap); and Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c from M. tuberculosis (148 aa), FASTA scores: opt: 330, E(): 2.2e-15, (39.75% identity in 151 aa overlap); etc.	Q7TW86	No	intermediary metabolism and respiration							IPR004378,IPR012349	Q7TW86	A0A1R3Y4I0				Rv3547		Rv3547			
NC_002945.3	Mycobrowser_v4	CDS	3969045	3969593	.	+	0	Mb3615	lpqE		POSSIBLE CONSERVED LIPOPROTEIN LPQE	Mb3615, lpqE, len: 182 aa. Equivalent to Rv3584,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Possible lpqE,conserved lipoprotein, equivalent to Q9ZBM7|MLCB1450.02|LPQE|ML0319 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (183 aa), FASTA scores: opt: 722,E(): 6.2e-37, (63.45% identity in 175 aa overlap). Also similar in part to Q9KK69 EXPORTED PROTEIN 996A010 (FRAGMENT) from Mycobacterium avium (41 aa), FASTA scores: opt: 180, E(): 0.00012, (69.25% identity in 39 aa overlap); and Q9L0R0|SCD8A.04c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (241 aa), FASTA scores: opt: 127,E(): 0.86, (27.15% identity in 173 aa overlap). Equivalent to AAK48048 from Mycobacterium tuberculosis strain CDC1551 (238 aa) but shorter 56 aa. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	X2BPC7,P65309	No	cell wall and cell processes								X2BPC7,P65309	P65309				Rv3584		Rv3584			
NC_002945.3	Mycobrowser_v4	CDS	3932368	3933111	.	+	0	Mb3580	echA20		PROBABLE ENOYL-COA HYDRATASE ECHA20 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)	Mb3580, echA20, len: 247 aa. Equivalent to Rv3550,len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 247 aa overlap). Probable echA20,enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. Q9A7B0|CC1814 from Caulobacter crescentus (275 aa), FASTA scores: opt: 488, E(): 3.5e-24, (36.4% identity in 239 aa overlap); O84978|PHAA from Pseudomonas putida (293 aa),FASTA scores: opt: 383, E(): 2e-17, (33.85% identity in 254 aa overlap); BAB48479|Q98LI4|MLL1009 from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 378, E(): 3.8e-17, (21.45% identity in 231 aa overlap); etc. COULD BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY.	Q7TW83	No								IPR001753	Q7TW83	A0A1R3Y4H1									
NC_002945.3	Mycobrowser_v4	CDS	3939019	3940179	.	-	0	Mb3586c	fadA6		PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA6 (ACETOACETYL-COA THIOLASE)	Mb3586c, fadA6, len: 386 aa. Equivalent to Rv3556c,len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 386 aa overlap). Probable fadA6,acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1091, E(): 2.9e-58, (48.1% identity in 399 aa overlap); Q9AAT4|CC0510 from Caulobacter crescentus (391 aa), FASTA scores: opt: 902,E(): 6.6e-47, (40.25% identity in 395 aa overlap); P45359|THL_CLOAB from Clostridium acetobutylicum (392 aa),FASTA scores: opt: 872, E(): 4.2e-45, (37.9% identity in 396 aa overlap); Q9I2A8|ATOB|PA2001 from Pseudomonas aeruginosa (393 aa), FASTA scores: opt: 872, E(): 4.2e-45,(41.3% identity in 397 aa overlap); etc. Contains PS00737 Thiolases signature 2. BELONGS TO THE THIOLASE FAMILY.	Q7TW78	No								IPR002155,IPR016038,IPR016039,IPR020613,IPR020616,IPR020617	Q7TW78	A0A1R3Y4G6									
NC_002945.3	Mycobrowser_v4	CDS	3941195	3942853	.	+	0	Mb3588	PPE64		ppe family protein ppe64	Mb3588, PPE64, len: 552 aa. Equivalent to Rv3558,len: 552 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 552 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1908, E(): 1.7e-83, (58.5% identity in 583 aa overlap).	Q7TW76	No								IPR000030,IPR002989	Q7TW76	A0A1R3Y660									
NC_002945.3	Mycobrowser_v4	CDS	3943647	3944804	.	-	0	Mb3590c	fadE30		PROBABLE ACYL-COA DEHYDROGENASE FADE30	Mb3590c, fadE30, len: 385 aa. Equivalent to Rv3560c, len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 385 aa overlap). Probable fadE30, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many e.g. Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 845, E(): 1.6e-47,(39.2% identity in 388 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 734,E(): 2.8e-40, (35.5% identity in 386 aa overlap); Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa),FASTA scores: opt: 656, E(): 3.2e-35, (37.9% identity in 351 aa overlap); etc. Also similar to acyl-CoA dehydrogenases from Mycobacterium tuberculosis e.g. P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FASTA scores: opt: 939, E(): 1.4e-53, (43.8% identity in 404 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TW74	No	lipid metabolism							IPR006091,IPR009075,IPR009100,IPR013786	Q7TW74	A0A1R3Y4H6				Rv3560c		Rv3560c			
NC_002945.3	Mycobrowser_v4	CDS	3944852	3946375	.	+	0	Mb3591	fadD3		PROBABLE FATTY-ACID-COA LIGASE FADD3 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)	Mb3591, fadD3, len: 507 aa. Equivalent to Rv3561,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 507 aa overlap). Probable fadD3,fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many substrate-CoA symthetases/ligases e.g. Q9KBC2|BH2006 LONG-CHAIN ACYL-COA SYNTHETASE from Bacillus halodurans (513 aa), FASTA scores: opt: 821, E(): 1.6e-43, (32.9% identity in 517 aa overlap); Q9EY88|FCS FERULOYL-COA SYNTHETASE from Amycolatopsis sp. HR167 (491 aa) FASTA scores: opt: 767, E(): 3.5e-40, (37.65% identity in 502 aa overlap); Q9ZIP5|MATB MALONYL CoA SYNTHETASE from Rhizobium leguminosarum (504 aa), FASTA scores: opt: 758,E(): 1.3e-39, (33.7% identity in 472 aa overlap); Q9CD27|FADD2|ML2546 ACYL-COA SYNTHASE from Mycobacterium leprae (548 aa), FASTA scores: opt: 700, E(): 5.6e-36,(31.85% identity in 515 aa overlap); P29212|LCFA_ECOLI|FADD|OLDD|B1805 LONG-CHAIN-FATTY-ACID--COA LIGASE from Escherichia coli strain K12 (561 aa), FASTA scores: opt: 532, E(): 6.3e-28,(30.0% identity in 533 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis eg O53306|FADD13|Rv3089|MTV013.10 (503 aa), FASTA scores: opt: 819, E(): 2.1e-43, (35.1% identity in 490 aa overlap). Contains PS00455 Putative AMP-binding domain signature.	Q7TW73	No								IPR000873,IPR020845,IPR025110	Q7TW73	A0A1R3Y4L9									
NC_002945.3	Mycobrowser_v4	CDS	3946376	3947509	.	+	0	Mb3592	fadE31		PROBABLE ACYL-COA DEHYDROGENASE FADE31	Mb3592, fadE31, len: 377 aa. Equivalent to Rv3562,len: 377 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 377 aa overlap). Probable fadE31,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa),FASTA scores: opt: 657, E(): 1.7e-34, (36.45% identity in 351 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 653, E(): 3.2e-34, (33.95% identity in 392 aa overlap); Q9EX72|MLHC from Rhodococcus erythropolis (324 aa) FASTA scores: opt: 631, E(): 6.5e-33, (36.95% identity in 330 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),FASTA scores: opt: 347, E(): 1e-15, (28.6% identity in 385 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. P96842|FADE30|Rv3560c|MTCY06G11.07c (385 aa), FASTA scores: opt: 843, E(): 2.3e-46, (38.95% identity in 380 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TW72	No								IPR006091,IPR009075,IPR009100,IPR013786	Q7TW72	A0A1R3Y4M5									
NC_002945.3	Mycobrowser_v4	CDS	3947506	3948465	.	+	0	Mb3593	fadE32		PROBABLE ACYL-COA DEHYDROGENASE FADE32	Mb3593, fadE32, len: 319 aa. Equivalent to Rv3563,len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 319 aa overlap). Probable fadE32,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 285,E(): 4.1e-10, (30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),FASTA scores: opt: 230, E(): 1.1e-07, (25.5% identity in 357 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis eg P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores: opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TW71	No								IPR009075,IPR009100,IPR013786	Q7TW71	A0A1R3Y4I6									
NC_002945.3	Mycobrowser_v4	CDS	3948462	3949418	.	+	0	Mb3594	fadE33		PROBABLE ACYL-COA DEHYDROGENASE FADE33	Mb3594, fadE33, len: 318 aa. Equivalent to Rv3564,len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 318 aa overlap). Probable fadE33,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa),FASTA scores: opt: 373, E(): 1.9e-15, (34.3% identity in 338 aa overlap); Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 277, E(): 1.4e-09, (31.95% identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from Streptomyces coelicolor (395 aa), FASTA scores: opt: 273,E(): 2.5e-09, (30.1% identity in 352 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. P96845|FADE32|Rv3563|MTCY06G11.10 (319 aa), FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TW70	No								IPR009075,IPR009100,IPR013786	Q7TW70	A0A1R3Y4J2									
NC_002945.3	Mycobrowser_v4	CDS	3949415	3950581	.	+	0	Mb3595	aspB		POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB (TRANSAMINASE A) (ASPAT) (GLUTAMIC--OXALOACETIC TRANSAMINASE) (GLUTAMIC--ASPARTIC TRANSAMINASE)	Mb3595, aspB, len: 388 aa. Equivalent to Rv3565,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 388 aa overlap). Possible aspB,aspartate aminotransferase (EC 2.6.1.1), similar to many e.g. Q9A5J2|CC2455 AMINOTRANSFERASE CLASS I from Caulobacter crescentus (381 aa), FASTA scores: opt: 1112,E(): 1e-61, (45.85% identity in 384 aa overlap); Q9HV76|PA4722 PROBABLE AMINOTRANSFERASE from Pseudomonas aeruginosa (390 aa), FASTA scores: opt: 863, E(): 3.1e-46,(37.2% identity in 390 aa overlap); Q9RWP3|DR0623 ASPARTATE AMINOTRANSFERASE from Deinococcus radiodurans (388 aa), FASTA scores: opt: 713, E(): 6.3e-37, (35.5% identity in 383 aa overlap); Q9HQK2|ASPC2|VNG1121G ASPARTATE AMINOTRANSFERASE from Halobacterium sp. strain NRC-1 (391 aa), FASTA scores: opt: 710, E(): 9.8e-37,(34.45% identity in 380 aa overlap); O33822|AAT_THEAQ|ASPC ASPARTATE AMINOTRANSFERASE from Thermus aquaticus (383 aa), FASTA scores: opt: 695, E(): 8.2e-36, (35.1% identity in 376 aa overlap); etc. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. BELONGS TO CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE (BY SIMILARITY).	Q7TW69	No	intermediary metabolism and respiration							IPR004838,IPR004839,IPR015421,IPR015422,IPR015424	Q7TW69	A0A1R3Y4K8				Rv3565		Rv3565			
NC_002945.3	Mycobrowser_v4	CDS	3950546	3951397	.	-	0	Mb3596c	nat		ARYLAMINE N-ACETYLTRANSFERASE NAT (ARYLAMINE ACETYLASE)	Mb3596c, nat, len: 283 aa. Equivalent to Rv3566c,len: 283 aa, from Mycobacterium tuberculosis H37Rv,(100.0% identity in 283 aa overlap). nat (alternate gene name: nhoA), arylamine N-acetyltransferase (EC 2.3.1.5) (see citation below), highly similar to O86309|NAT_MYCSM ARYLAMINE N-ACETYLTRANSFERASE from Mycobacterium smegmatis (see citation below) (275 aa), FASTA scores: opt: 1114,E(): 3e-66, (60.95% identity in 274 aa overlap). Also highly similar to others e.g. Q98D42|BAB51429|MLR4870 from Rhizobium loti (Mesorhizobium loti) (278 aa), FASTA scores: opt: 697, E(): 1.1e-38, (44.1% identity in 272 aa overlap); P77567|NHOA_ECOLI|B1463 from Escherichia coli strain K12 (281 aa), FASTA scores: opt: 537, E(): 4.4e-28,(38.85% identity in 273 aa overlap); Q00267|NHOA_SALTY from Salmonella typhimurium (281 aa), FASTA scores: opt: 507, E(): 4.3e-26, (34.8% identity in 273 aa overlap); etc. BELONGS TO THE ARYLAMINE N-ACETYLTRANSFERASE FAMILY. Note that previously known as nhoA (332 aa) and that nucleotide 4007874 has been changed since first submission (G deleted).	X2BPU6,P0A5L9	No									X2BPU6,P0A5L9	P0A5L9									
NC_002945.3	Mycobrowser_v4	CDS	3951934	3952497	.	-	0	Mb3598c	hsab		possible oxidoreductase. possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase.	Mb3598c, -, len: 187 aa. Equivalent to Rv3567c,len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 187 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. O69360 ORF61 PROTEIN from Rhodococcus erythropolis (194 aa) FASTA scores: opt: 974, E(): 3e-59, (77.05% identity in 183 aa overlap); Q9JN75|MMYF PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (174 aa), FASTA scores: opt: 451,E(): 1e-23, (43.65% identity in 158 aa overlap); P54990|NTAB_CHEHE|NMOB NITRILOTRIACETATE MONOOXYGENASE COMPONENT B (EC 1.14.13.-) from Chelatobacter heintzii (322 aa), FASTA scores: opt: 409, E(): 1.3e-20, (38.3% identity in 167 aa overlap)Chelatobacter heintzii; AAK62356 PUTATIVE NADH:FMN OXIDOREDUCTASE from Burkholderia sp. DBT1 (177 aa), FASTA scores: opt: 360,E(): 1.6e-17, (36.15% identity in 155 aa overlap).	Q7TW67	No	intermediary metabolism and respiration							IPR002563,IPR012349	Q7TW67	A0A1R3Y661				Rv3567c		Rv3567c			
NC_002945.3	Mycobrowser_v4	CDS	3963357	3964598	.	+	0	Mb3609	arsB2		POSSIBLE ARSENICAL PUMP INTEGRAL MEMBRANE PROTEIN ARSB2	Mb3609, arsB2, len: 413 aa. Equivalent to Rv3578,len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 413 aa overlap). Possible arsB2,arsenical pump integral membrane protein, similar to many e.g. Q9I1J6|ARSB|PA2278 from Pseudomonas aeruginosa (427 aa), FASTA scores: opt: 375, E(): 3.1e-15, (32.15% identity in 429 aa overlap); Q9K8K7|ARSB|BH2999 from Bacillus halodurans (436 aa), FASTA scores: opt: 360, E(): 2.5e-14, (28.7% identity in 432 aa overlap); P52146|ARB2_ECOLI from Escherichia coli (plasmid R46) (429 aa), FASTA scores: opt: 345, E(): 2e-13, (29.8% identity in 426 aa overlap); etc. Also highly similar to Q9KYM0|SC9H11.21c PROBABLE MEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 730,E(): 1.7e-36, (53.95% identity in 443 aa overlap). SEEMS TO BELONG TO THE ARS FAMILY.	Q7TW56	No								IPR000802	Q7TW56	A0A1R3Y561									
NC_002945.3	Mycobrowser_v4	CDS	3952512	3953414	.	-	0	Mb3599c	hsac		3,4-dhsa dioxygenase	Mb3599c, bphC, len: 300 aa. Equivalent to Rv3568c,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 300 aa overlap). Probable bphC,2,3-dihydroxybiphenyl 1,2-dioxygenase (EC 1.13.11.39),highly similar to other e.g. Q9KWQ5|BPHC5 from Rhodococcus sp. RHA1 (300 aa), FASTA scores: opt: 1715, E(): 3.8e-103,(82.15% identity in 297 aa overlap); O50479|EDOB from Rhodococcus rhodochrous (300 aa) FASTA scores: opt: 1714,E(): 4.4e-103, (82.5% identity in 297 aa overlap); O69359|BPHC6 from Rhodococcus erythropolis (300 aa), FASTA scores: opt: 1647, E(): 9.1e-99, (78.25% identity in 299 aa overlap); Q9RBT2|BPHC1 from Pseudomonas sp. SY5 (301 aa) Pseudomonas sp. SY5 (298 aa) FASTA scores: opt: 767,E(): 3.9e-42, (42.8% identity in 299 aa overlap); P47228|BPHC_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (297 aa), FASTA scores: opt: 670, E(): 6.8e-36,(40.55% identity in 296 aa overlap); etc. Contains PS00082 Extradiol ring-cleavage dioxygenases signature. BELONGS TO THE EXTRADIOL RING-CLEAVAGE DIOXYGENASE FAMILY.	Q7TW66	No								IPR000486,IPR004360	Q7TW66	A0A1R3Y552									
NC_002945.3	Mycobrowser_v4	CDS	3954301	3955485	.	-	0	Mb3601c	hsaa		possible oxidoreductase. possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase.	Mb3601c, -, len: 394 aa. Equivalent to Rv3570c,len: 394 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 394 aa overlap). Possible oxidoreductase (EC 1.-.-.-), most similar to hydroxylases and oxygenases (and also some similarity to acyl-coa dehydrogenases) e.g. O69349 HYDROXYLASE from Rhodococcus erythropolis (393 aa), FASTA scores: opt: 958, E(): 1.1e-53, (39.95% identity in 383 aa overlap); P26698|PIGM_RHOSO PIGMENT PROTEIN from Rhodococcus sp. strain ATCC 21145 (387 aa), FASTA scores: opt: 665, E(): 5.4e-35, (32.2% identity in 382 aa overlap); Q9ZGA9|LANZ5 OXYGENASE HOMOLOG from Streptomyces cyanogenus (397 aa) FASTA scores: opt: 588, E(): 4.5e-30, (30.55% identity in 386 aa overlap); Q9F0J3|NCNH HYDROXYLASE from Streptomyces arenae (405 aa), FASTA scores: opt: 580, E(): 1.5e-29,(31.25% identity in 336 aa overlap); O69789|BPFA INDOLE DIOXYGENASE from Rhodococcus opacus (399 aa), FASTA scores: opt: 558, E(): 3.7e-28, (31.8% identity in 387 aa overlap); etc.	Q7TW64	No	intermediary metabolism and respiration							IPR006091,IPR009075,IPR009100,IPR013107,IPR013786	Q7TW64	A0A1R3Y4N0				Rv3570c		Rv3570c			
NC_002945.3	Mycobrowser_v4	CDS	3955632	3956708	.	+	0	Mb3602	kshb		reductase component of 3-ketosteroid-9-alpha-hydroxylase kshb	Mb3602, hmp, len: 358 aa. Equivalent to Rv3571,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Possible hmp,oxidoreductase, hemoglobine-related protein (see citation below) (EC 1.-.-.-), similar to several e.g. Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter sp (336 aa) FASTA scores: opt: 748, E(): 1.5e-38, (34.95% identity in 346 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from Pseudomonas putida (337 aa), FASTA scores: opt: 723, E(): 5.2e-37, (36.35% identity in 341 aa overlap); AAK65059|SMA0752 POSSIBLE DIOXYGENASE REDUCTASE SUBUNIT from Rhizobium meliloti (Sinorhizobium meliloti) (353 aa) FASTA scores: opt: 495, E(): 4.9e-23, (31.9% identity in 345 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE (356 aa), FASTA scores: opt: 364, E(): 5.1e-15, (34.45% identity in 357 aa overlap); Q9L131|HMPA FLAVOHEMOPROTEIN from Streptomyces coelicolor (398 aa), FASTA scores: opt: 352, E(): 3e-14, (32.8% identity in 247 aa overlap); etc. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. Note that it has been shown hmp transcription increased at early stationary phase and is lower at late stationary phase and during exponential growth.	Q7TW63	No	intermediary metabolism and respiration							IPR001041,IPR001221,IPR001433,IPR001709,IPR006058,IPR008333,IPR012675,IPR017927,IPR017938	Q7TW63	A0A1R3Y4P1				Rv3571		Rv3571			
NC_002945.3	Mycobrowser_v4	CDS	3957292	3959427	.	-	0	Mb3604c	fadE34		PROBABLE ACYL-COA DEHYDROGENASE FADE34	Mb3604c, fadE34, len: 711 aa. Equivalent to Rv3573c, len: 711 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 711 aa overlap). Probable fadE34, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to others, especially in C-terminal half, e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa) FASTA scores: opt: 780, E(): 2.8e-39, (44.1% identity in 347 aa overlap); Q9A6N8|CC2049 from Caulobacter crescentus (401 aa), FASTA scores: opt: 705, E(): 8.7e-35, (41.5% identity in 342 aa overlap); Q9EX72|MLHC from Rhodococcus erythropolis (324 aa), FASTA scores: opt: 673, E(): 6.1e-33, (42.05% identity in 283 aa overlap); P41367|ACDM_PIG|ACADM from Sus scrofa (Pig)(421 aa) FASTA scores: opt: 325, E(): 4.9e- 13, (28.5% identity in 368 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. P95097|FADE22|Rv3061c|MTCY22D7.20 (721 aa), FASTA scores: opt: 1635, E(): 2.7e-90, (42.65% identity in 729 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TW61	No	lipid metabolism							IPR006091,IPR009075,IPR009100,IPR013786	Q7TW61	A0A1R3Y4J8				Rv3573c		Rv3573c			
NC_002945.3	Mycobrowser_v4	CDS	3959699	3960298	.	+	0	Mb3605	kstr		transcriptional regulatory protein kstr (probably tetr-family)	Mb3605, -, len: 199 aa. Equivalent to Rv3574, len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Probable transcriptional regulator tetR family, similar to others e.g. Q9KXK1|SCC53.10 from Streptomyces coelicolor (250 aa) FASTA scores: opt: 492, E(): 4.8e-25, (44.8% identity in 183 aa overlap); Q9RA03|KSTR from Rhodococcus erythropolis (208 aa), FASTA scores: opt: 294, E(): 3.1e-12, (28.9% identity in 187 aa overlap); BAB54261|MLR7895 from Rhizobium loti (Mesorhizobium loti) (193 aa), FASTA scores: opt: 166, E(): 0.00062, (32.05% identity in 78 aa overlap); P17446|BETI_ECOLI|B0313 from Escherichia coli strain K12 (195 aa), FASTA scores: opt: 142, E(): 0.0034,(25. 6% identity in 168 aa overlap); etc. Equivalent to AAK48038 from Mycobacterium tuberculosis strain CDC1551 (243 aa) but shorter 44 aa. Contains possible helix-turn-helix motif from aa 37-58 (+3.70 SD). POSSIBLY BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TW60	No	regulatory proteins							IPR001647,IPR009057,IPR015893	Q7TW60	A0A1R3Y4L5				Rv3574		Rv3574			
NC_002945.3	Mycobrowser_v4	CDS	3961573	3962286	.	+	0	Mb3607	lppH		POSSIBLE CONSERVED LIPOPROTEIN LPPH	Mb3607, lppH, len: 237 aa. Equivalent to Rv3576,len: 237 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 237 aa overlap). Possible lppH,conserved lipoprotein, similar in part with proteins from Mycobacterium tuberculosis; C-terminus of Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50.16 PROBABLE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (626 aa) FASTA scores: opt: 396, E(): 6.5e-19, (36.0% identity in 200 aa overlap); and with P71740|LPPR|Rv2403c|MTCY253.17 PROBABLE LIPOPROTEIN PROTEIN (251 aa), FASTA scores: opt: 134, E(): 0.087, (22.7% identity in 207 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as pknM.	Q7TW58	No	cell wall and cell processes							IPR026954	Q7TW58	A0A1R3Y4L0				Rv3576		Rv3576			
NC_002945.3	Mycobrowser_v4	CDS	3965610	3967019	.	-	0	Mb3611c	cysS1		CYSTEINYL-TRNA SYNTHETASE 1 CYSS1 (CYSTEINE--TRNA LIGASE 1) (CYSRS 1) (CYSTEINE TRANSLASE)	Mb3611c, cysS1, len: 469 aa. Equivalent to Rv3580c,len: 469 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 469 aa overlap). Probable cysS1,cysteinyl-tRNA synthetase (EC 6.1.1.16), equivalent to P57990|SYC1_MYCLE|CYSS1|CYSS|ML0323 CYSTEINYL-TRNA SYNTHETASE 1 from Mycobacterium leprae (473 aa) FASTA scores: opt: 2825, E(): 3.4e-172, (86.5% identity in 467 aa overlap). Also similar to many e.g. Q9L0Q6|SCD8A.08 from Streptomyces coelicolor (613 aa), FASTA scores: opt: 1834, E(): 4.7e-109, (57.5% identity in 461 aa overlap); Q9I2U7|CYSS|PA1795 from Pseudomonas aeruginosa (460 aa) FASTA scores: opt: 1197, E(): 1.2e-68, (41.65% identity in 468 aa overlap); P21888|SYC_ECOLI P21888|CYSS|B0526 from Escherichia coli strain K12 (461 aa), FASTA scores: opt: 1189, E(): 4e-68, (43.0% identity in 463 aa overlap); etc. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. STRONGLY SIMILAR TO METHIONYL-TRNA SYNTHETASE.	X2BPV5,P0A635	No									X2BPV5,P0A635	P0A635									
NC_002945.3	Mycobrowser_v4	CDS	3967084	3967563	.	-	0	Mb3612c	ispF		PROBABLE 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE ISPF (MECPS)	Mb3612c, ispF, len: 159 aa. Equivalent to Rv3581c,len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). Probable ispF,2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC not defined), equivalent to Q9CCW5|ML0322 PUTATIVE 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE from Mycobacterium leprae (158 aa), FASTA scores: opt: 830,E(): 2.9e-47, (79.1% identity in 158 aa overlap). Also highly similar to others e.g. Q9L0Q7|ISPF_STRCO|SCD8A.07 from Streptomyces coelicolor (170 aa), FASTA scores: opt: 585, E(): 2.9e-31, (56.5% identity in 154 aa overlap); Q9PDT5|ISPF_XYLFA|XF1294 from Xylella fastidiosa (176 aa),FASTA scores: opt: 398, E(): 4.6e-19, (44.9% identity in 156 aa overlap); Q08113|ISDF_RHOCA|ISPDF from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (379 aa), FASTA scores: opt: 387, E(): 4.5e-18, (42.85% identity in 154 aa overlap) (only similar with C-terminal end of this bifunctional protein ISPD and ISPF); Q06756|ISPF_BACSU from Bacillus subtilis (158 aa), FASTA scores: opt: 367,E(): 4.5e-17, (41.2% identity in 153 aa overlap); etc. BELONGS TO THE ISPF FAMILY.	X2BNN3,P65184	No									X2BNN3,P65184	P65184									
NC_002945.3	Mycobrowser_v4	CDS	3967560	3968255	.	-	0	Mb3613c	ispD		4-diphosphocytidyl-2c-methyl-d-erythritol synthase ispd (mep cytidylyltransferase) (mct)	Mb3613c, ispD, len: 231 aa. Equivalent to Rv3582c,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 231 aa overlap). Probable ispD,4-diphosphocytidyl-2C-methyl-D-erythritol synthase (EC 2.7.7.-), equivalent to Q9CCW6|ML0321 PUTATIVE 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHASE from Mycobacterium leprae (241 aa), FASTA scores: opt: 694,E(): 1.7e-35, (66.95% identity in 236 aa overlap). Also highly similar to others e.g. Q9L0Q8|ISPD_STRCO|SCD8A.06 from Streptomyces coelicolor (270 aa), FASTA scores: opt: 537, E(): 7.5e-26, (43.4% identity in 242 aa overlap); P74323|ISPD_SYNY3|SLR0951 from Synechocystis sp. strain PCC 6803 (230 aa), FASTA scores: opt: 410, E(): 3.8e-18,(36.15% identity in 224 aa overlap); Q9KGF8|ISPD_BACHD|BH0107 from Bacillus halodurans (228 aa) FASTA scores: opt: 367, E(): 1.6e-15, (34.65% identity in 228 aa overlap); Q08113|ISDF_RHOCA|ISPDF from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (379 aa)FASTA scores: opt: 359, E(): 7.8e-15, (34.1% identity in 223 aa overlap) (only similar with N-terminus of this bifunctional protein ISPD and ISPF); Q46893|ISPD_ECOLI|B2747 from Escherichia coli strain K12 (235 aa), FASTA scores: opt: 336, E(): 1.3e-13, (33.65% identity in 223 aa overlap); etc. BELONGS TO THE ISPD FAMILY.	X2BP42,Q7TW54	No									X2BP42,Q7TW54	Q7TW54									
NC_002945.3	Mycobrowser_v4	CDS	3973708	3974622	.	+	0	Mb3620	mutY		probable adenine glycosylase muty	Mb3620, mutY, len: 304 aa. Equivalent to Rv3589,len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Probable mutY,adenine glycosylase (EC 3.2.2.-), equivalent to Q9CBJ0|MUTY|ML1920 PROBABLE DNA GLYCOSYLASE from Mycobacterium leprae (297 aa), FASTA scores: opt: 1592,E(): 2.6e-94, (74.9% identity in 303 aa overlap). Also similar to many DNA glycosylases (generally adenine glycosylases) e.g. Q9S6T7|SCE94.06 from Streptomyces coelicolor (308 aa), FASTA scores: opt: 965, E(): 2.6e-54,(50.5% identity in 297 aa overlap); Q9S6G1|MUTY from Streptomyces antibioticus (307 aa), FASTA scores: opt: 901, E(): 3.1e-50, (48.5% identity in 303 aa overlap); Q9HPQ6|MUTY|VNG1520G from Halobacterium sp. strain NRC-1 (312 aa), FASTA scores: opt: 566, E(): 7.2e-29, (39.85% identity in 296 aa overlap); BAB53965|MLL7523 from Rhizobium loti (Mesorhizobium loti) (396 aa), FASTA scores: opt: 511, E(): 2.8e-25, (39.65% identity in 237 aa overlap); Q05869|MUTY_SALTY|MUTB from Salmonella typhimurium (350 aa), FASTA scores: opt: 421, E(): 3.8e-20, (35.2% identity in 227 aa overlap); etc. COULD BELONG TO THE NTH/MUTY FAMILY.	Q7TW49	No	information pathways							IPR000445,IPR003265,IPR003651,IPR011257,IPR023170	Q7TW49	A0A1R3Y4K5				Rv3589		Rv3589			
NC_002945.3	Mycobrowser_v4	CDS	3969659	3971101	.	+	0	Mb3616	radA		DNA REPAIR PROTEIN RADA (DNA REPAIR PROTEIN SMS)	Mb3616, radA, len: 480 aa. Equivalent to Rv3585,len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Probable radA, DNA repair protein, similar to many e.g. Q9X8L5|SCE94.02 from Streptomyces coelicolor (469 aa), FASTA scores: opt: 1607,E(): 3.1e-84, (56.15% identity in 454 aa overlap); Q9JV51|RADA|NMA0992 from Neisseria meningitidis (serogroup A) (459 aa), FASTA scores: opt: 1275, E(): 2.5e-65, (45.0% identity in 458 aa overlap); and Q9K040|RADA|NMB0782 from Neisseria meningitidis (serogroup B) (459 aa), FASTA scores: opt: 1269, E(): 5.4e-65, (44.5% identity in 456 aa overlap); P37572|RADA_BACSU|SMS from Bacillus subtilis (458 aa), FASTA scores: opt: 1204, E(): 2.7e-61, (39.55% identity in 455 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE RADA FAMILY.	X2BPV8,P65954	No	information pathways								X2BPV8,P65954	P65954				Rv3585		Rv3585			
NC_002945.3	Mycobrowser_v4	CDS	3974619	3976373	.	-	0	Mb3621c	PE_PGRS58		pe-pgrs family protein pe_pgrs58	Mb3621c, PE_PGRS58, len: 584 aa. Equivalent to Rv3590c, len: 584 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 584 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores: opt: 2005,E(): 1.4e-70, (54.95% identity in 646 aa overlap).	Q7TW48	No								IPR000084	Q7TW48	A0A1R3Y4P4									
NC_002945.3	Mycobrowser_v4	CDS	3977272	3977589	.	+	0	Mb3623	mhud		possible heme degrading protein mhud	Mb3623, TB11.2, len: 105 aa. Equivalent to Rv3592,len: 105 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 105 aa overlap). TB11.2, conserved hypothetical protein (see citations from 2000 below),equivalent to Q9CBI8|ML1922 HYPOTHETICAL PROTEIN from Mycobacterium leprae (105 aa) FASTA scores: opt: 591, E(): 2.5e-34, (84.6% identity in 104 aa overlap). Shows some similarity with other bacterial hypothetical proteins e.g. Q9RXN8|DR0272 from Deinococcus radiodurans (109 aa), FASTA scores: opt: 178, E(): 1e-05, (34.3% identity in 102 aa overlap); P38049|YHGC_BACSU from Bacillus subtilis (166 aa) FASTA scores: opt: 175, E(): 2.4e-05, (40.85% identity in 71 aa overlap); Q9K649|BH3883 from Bacillus halodurans (102 aa) FASTA scores: opt: 162, E(): 0.00012, (33.75% identity in 80 aa overlap); etc.	Q7TW46	No								IPR007138,IPR011008	Q7TW46	A0A1R3Y4L7									
NC_002945.3	Mycobrowser_v4	CDS	3977567	3978925	.	+	0	Mb3624	lpqF		PROBABLE CONSERVED LIPOPROTEIN LPQF	Mb3624, lpqF, len: 452 aa. Equivalent to Rv3593,len: 452 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 452 aa overlap). Probable lpqF,conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 PROBALE SECRETED PROTEIN from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also similar to Q9KJ91 HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces clavuligerus (430 aa), FASTA scores: opt: 609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 BETA LACTAMASE-RELATED PROTEIN from Deinococcus radiodurans (499 aa), FASTA scores: opt: 322,E(): 2.5e-12, (28.25% identity in 322 aa overlap). Equivalent to AAK48057 from Mycobacterium tuberculosis strain CDC1551 (438 aa) but longer 14 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	Q7TW45	No	cell wall and cell processes							IPR012338	Q7TW45	A0A1R3Y4M3				Rv3593		Rv3593			
NC_002945.3	Mycobrowser_v4	CDS	3979813	3981291	.	-	0	Mb3626c	PE_PGRS59		pe-pgrs family protein pe_pgrs59	Mb3626c, PE_PGRS59, len: 492 aa. Equivalent to 5' end of Rv3595c, len: 439 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 257 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores: opt: 1644, E(): 1.2e-57, (58.75% identity in 492 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (a-*) and a 27 bp insertion (*-gcgcgccggggccaccgtttccgccgg), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa).	Q7TW43	No								IPR000084	Q7TW43	A0A1R3Y4K4									
NC_002945.3	Mycobrowser_v4	CDS	3987522	3988451	.	-	0	Mb3632c	panC		pantoate--beta-alanine ligase panc (pantothenate synthetase) (pantoate activating enzyme)	Mb3632c, panC, len: 309 aa. Equivalent to Rv3602c,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable panC,pantoate--beta-alanine ligase (EC 6.3.2.1), equivalent to O69524|PANC_MYCLE|ML0230|MLCB2548.01c PANTOATE--BETA-ALANINE LIGASE from Mycobacterium leprae (313 aa), FASTA scores: opt: 1541, E(): 3.4e-84, (82.15% identity in 297 aa overlap). Also similar to others e.g. O67891|PANC_AQUAE|AQ_2132 from Aquifex aeolicus (282 aa) FASTA scores: opt: 774, E(): 8.6e-39, (46.9% identity in 273 aa overlap); Q9HV69|PANC_PSEAE|PA4730 from Pseudomonas aeruginosa (283 aa), FASTA scores: opt: 770, E(): 1.5e-38,(51.45% identity in 276 aa overlap); Q9A6C8|CC2166 from Caulobacter crescentus (285 aa), FASTA scores: opt: 744,E(): 5.2e-37, (47.75% identity in 268 aa overlap); P31663|PANC_ECOLI|B0133 from Escherichia coli strain K12 (283 aa), FASTA scores: opt: 695, E(): 4.1e-34, (46.1% identity in 271 aa overlap); etc. BELONGS TO THE PANTOTHENATE SYNTHETASE FAMILY.	X2BP59,P0A5R1	No									X2BP59,P0A5R1	P0A5R1									
NC_002945.3	Mycobrowser_v4	CDS	3981399	3983945	.	-	0	Mb3627c	clpC		probable atp-dependent protease atp-binding subunit clpc1	Mb3627c, clpC, len: 848 aa. Equivalent to Rv3596c,len: 848 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 848 aa overlap). Probable clpC,ATP-dependent clp protease ATP-binding subunit (EC 3.4.-.-), equivalent to P24428|CLPC_MYCLE PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium leprae (848 aa), FASTA scores: opt: 5286,E(): 0, (97.15% identity in 845 aa overlap). Also highly similar to members of the clpA/clpB family e.g. Q9S6T8|SCE94.24c from Streptomyces coelicolor (841 aa) FASTA scores: opt: 4399, E(): 0, (81.0% identity in 848 aa overlap); Q9KGG2|CLPC|BH0103 from Bacillus halodurans (813 aa), FASTA scores: opt: 3279, E(): 3.8e-173, (61.9% identity in 808 aa overlap); Q55662|CLPC|SLL0020 from Synechocystis sp. strain PCC 6803 (821 aa), FASTA scores: opt: 3201, E(): 7.6e-169, (60.5% identity in 820 aa overlap); P51332|CLPC_PORPU from Porphyra purpurea (821 aa), FASTA scores: opt: 3045, E(): 3e-160, (57.65% identity in 817 aa overlap); P37571|CLPC_BACSU|MECB from Bacillus subtilis (810 aa), FASTA scores: opt: 2969, E(): 4.6e-156, (61.15% identity in 811 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CLPA/CLPB FAMILY, CLPC SUBFAMILY.	X2BNQ0,P0A523	No									X2BNQ0,P0A523	P0A523									
NC_002945.3	Mycobrowser_v4	CDS	3984664	3986181	.	-	0	Mb3629c	lysS		LYSYL-TRNA SYNTHETASE 1 LYSS (LYSINE--TRNA LIGASE 1) (LYSRS 1) (LYSINE TRANSLASE)	Mb3629c, lysS, len: 505 aa. Equivalent to Rv3598c,len: 505 aa, from Mycobacterium tuberculosis H37Rv,(100.0% identity in 505 aa overlap). Probable lysS,lysyl-tRNA synthetase 1 (EC 6.1.1.6), equivalent to P46861|SYK_MYCLE|LYSS|ML0233 LYSYL-TRNA SYNTHETASE from Mycobacterium leprae (507 aa), FASTA scores: opt: 2835,E(): 4.5e-172, (85.45% identity in 501 aa overlap); and similar with C-terminal part of Q9CC23|LYSX|ML1393 C-TERM LYSYL-TRNA SYNTHASE from Mycobacterium leprae (1039 aa) FASTA scores: opt: 1257, E(): 7.6e-72, (44.55% identity in 505 aa overlap). Also similar to others e.g. P37477|SYK_BACSU|LYSS from Bacillus subtilis (499 aa) FASTA scores: opt: 1294, E(): 1.9e-74, (42.35% identity in 498 aa overlap); Q9RHV9|SYK_BACST|LYSS from Bacillus stearothermophilus (494 aa), FASTA scores: opt: 1258, E(): 3.5e-72, (41.15% identity in 498 aa overlap); Q9PEB6|SYK_XYLFA|LYSS|XF1112 from Xylella fastidiosa (506 aa), FASTA scores: opt: 1228, E(): 2.9e-70, (43.05% identity in 495 aa overlap); etc. Also similar to P94974|SYK2_MYCTU|LYSS2|LYSX|Rv1640c|MTCY06H11.04c LYSYL-TRNA SYNTHETASE 2 from Mycobacterium tuberculosis (1172 aa), FASTA scores: opt: 1295, E(): 3.3e-74, (45.65% identity in 506 aa overlap). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BNU4,P67608	No									X2BNU4,P67608	P67608									
NC_002945.3	Mycobrowser_v4	CDS	3987103	3987522	.	-	0	Mb3631c	panD		PROBABLE ASPARTATE 1-DECARBOXYLASE PRECURSOR PAND (ASPARTATE ALPHA-DECARBOXYLASE)	Mb3631c, panD, len: 139 aa. Equivalent to Rv3601c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable panD,aspartate 1-decarboxylase (EC 4.1.1.11), identical to Q9CD57|PAND|ML0231 PUTATIVE ASPARTATE-1-DECARBOXYLASE from Mycobacterium leprae (142 aa), FASTA scores: opt: 733,E(): 5.5e-41, (82.85% identity in 140 aa overlap). Also highly similar to many e.g. CAC44328|PAND from Streptomyces coelicolor (139 aa), FASTA scores: opt: 578,E(): 6.4e-31, (75.0% identity in 120 aa overlap); Q9X4N0|PAND from Corynebacterium glutamicum (Brevibacterium flavum) (136 aa), FASTA scores: opt: 506,E(): 3e-26, (62.2% identity in 135 aa overlap); P52999|PAND_BACSU from Bacillus subtilis (127 aa) FASTA scores: opt: 421, E(): 9.6e-21, (54.75% identity in 123 aa overlap); P31664|PAND_ECOLI|B0131 from Escherichia coli strain K12 (126 aa), FASTA scores: opt: 388, E(): 1.3e-18,(50.45% identity in 113 aa overlap); etc.	X2BNQ4,P65661	No									X2BNQ4,P65661	P65661									
NC_002945.3	Mycobrowser_v4	CDS	3991422	3991988	.	-	0	Mb3636c	folK		2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINEPYROPHOSPHOKINASE FOLK (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE) (PPPK) (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE DIPHOSPHOKINASE) (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-DIPHOSPHOKINASE) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN DIPHOSPHOKINASE)	Mb3636c, folK, len: 188 aa. Equivalent to Rv3606c,len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 188 aa overlap). Probable folK,2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase (EC 2.7.6.3), equivalent to O69528|HPPK_MYCLE|FOLK|ML0226MLCB2548.05c 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE from Mycobacterium leprae (191 aa) FASTA scores: opt: 772, E(): 1.2e-44, (63.15% identity in 190 aa overlap). Also similar to many e.g. P71512|HPPK_METEX|FOLK|FOLA from Methylobacterium extorquens (158 aa), FASTA scores: opt: 292, E(): 1.4e-12,(36.85% identity in 171 aa overlap); O33726|HPPK_STRPY|FOLK|SPY1100 from Streptococcus pyogenes (166 aa), FASTA scores: opt: 234, E(): 1.1e-08, (34.3% identity in 175 aa overlap); Q9X8I1|SCE9.08 from Streptomyces coelicolor (203 aa), FASTA scores: opt: 232,E(): 1.7e-08, (43.25% identity in 185 aa overlap); P26281|HPPK_ECOLI|FOLK|B0142 from Escherichia coli strain K12 (158 aa), FASTA scores: opt: 198, E(): 2.6e-06,(32.85% identity in 143 aa overlap); etc. BELONGS TO THE HPPK FAMILY.	X2BNQ7,P64144	No									X2BNQ7,P64144	P64144									
NC_002945.3	Mycobrowser_v4	CDS	3991985	3992386	.	-	0	Mb3637c	folB		PROBABLE DIHYDRONEOPTERIN ALDOLASE FOLB (DHNA)	Mb3637c, folB, len: 133 aa. Equivalent to Rv3607c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Probable folB,dihydroneopterin aldolase (EC 4.1.2.25), equivalent to O69529|FOLB_MYCLE|ML0225|MLCB2548.06c PROBABLE DIHYDRONEOPTERIN ALDOLASE from Mycobacterium leprae (132 aa), FASTA scores: opt: 673, E(): 5.1e-37, (74.8% identity in 131 aa overlap). Also similar to many e.g. Q9X8I0|FOLB_STRCO|SCE9.07 from Streptomyces coelicolor (119 aa), FASTA scores: opt: 334, E(): 4.5e-15, (46.15% identity in 117 aa overlap); P74342|FOLB_SYNY3|SLR1626 from Synechocystis sp. strain PCC 6803 (118 aa) FASTA scores: opt: 287, E(): 5e-12, (38.45% identity in 117 aa overlap); P28823|FOLB_BACSU|FOLA from Bacillus subtilis (120 aa), FASTA scores: opt: 283, E(): 9.2e-12, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE DHNA FAMILY. Note that previously known as folX.	X2BP64,P0A581	No									X2BP64,P0A581	P0A581									
NC_002945.3	Mycobrowser_v4	CDS	3998327	3999505	.	-	0	Mb3646c	espa		esx-1 secretion-associated protein a, espa	Mb3646c, -, len: 392 aa. Equivalent to Rv3616c,len: 392 aa, from Mycobacterium tuberculosis strain H37RV,(99.5% identity in 392 aa overlap). Conserved hypothetical ala-, gly-rich protein, equivalent to Q49722|ML0405|B1620_C2_213|MLCL383.01 HYPOTHETICAL 40.8 KDA PROTEIN from Mycobacterium leprae (394 aa) FASTA scores: opt: 1620, E(): 5.3e-75, (62.7% identity in 394 aa overlap). Also similar to P96213|Rv3864|MTCY01A6.04c HYPOTHETICAL 42.1 KDA PROTEIN from Mycobacterium tuberculosis (402 aa), FASTA scores: opt: 389, E(): 1.1e-12, (31.75% identity in 400 aa overlap).	Q7TW34	No	cell wall and cell processes								Q7TW34	A0A1R3Y4Q8				Rv3616c		Rv3616c			
NC_002945.3	Mycobrowser_v4	CDS	3992379	3993221	.	-	0	Mb3638c	folP1		DIHYDROPTEROATE SYNTHASE 1 FOLP (DHPS 1) (DIHYDROPTEROATE PYROPHOSPHORYLASE 1) (DIHYDROPTEROATE DIPHOSPHORYLASE 1)	Mb3638c, folP1, len: 280 aa. Equivalent to Rv3608c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Probable folP1,dihydropteroate synthase 1 (EC 2.5.1.15), equivalent to O69530|FOLP (alias Q9S0T0|FOLP and Q9R2U9|FOLP) DIHYDRONEOPTERIN ALDOLASE from Mycobacterium leprae (284 aa), FASTA scores: opt: 1418, E(): 7.2e-77, (76.75% identity in 284 aa overlap). Also highly similar to many e.g. Q9X8H8|SCE9.05 from Streptomyces coelicolor (288 aa),FASTA scores: opt: 953, E(): 2.4e-49, (56.0% identity in 266 aa overlap); Q9A3I0|CC3224 from Caulobacter crescentus (274 aa), FASTA scores: opt: 682, E(): 2.6e-33, (45.5% identity in 268 aa overlap); P73248|DHPS_SYNY3|FOLP|SLR2026 from Synechocystis sp. strain PCC 6803 (289 aa), FASTA scores: opt: 665, E(): 2.7e-32, (44.55% identity in 265 aa overlap); P26282|DHPS_ECOLI|FOLP|B3177 from Escherichia coli strain K12 (282 aa), FASTA scores: opt: 642, E(): 6.1e-31,(41.95% identity in 274 aa overlap); etc. Contains PS00792 Dihydropteroate synthase signature 1, PS00793 Dihydropteroate synthase signature 2. SIMILAR TO OTHER SPECIES DHPS.	X2BNV3,P0A579	No									X2BNV3,P0A579	P0A579									
NC_002945.3	Mycobrowser_v4	CDS	3993218	3993826	.	-	0	Mb3639c	folE		GTP CYCLOHYDROLASE I FOLE (GTP-CH-I)	Mb3639c, folE, len: 202 aa. Equivalent to Rv3609c,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Probable folE (alternate gene name: gchA), GTP cyclohydrolase I (EC 3.5.4.16), equivalent to O69531|GCH1_MYCLE|FOLE|ML0223|MLCB2548.08c GTP CYCLOHYDROLASE I from Mycobacterium leprae (205 aa) FASTA scores: opt: 1112, E(): 3.8e-63, (81.95% identity in 205 aa overlap). Also highly similar to many e.g. Q9X8I3|GCH1_STRCO|FOLE|SCE9.10c from Streptomyces coelicolor (201 aa), FASTA scores: opt: 873, E(): 4.2e-48,(67.4% identity in 187 aa overlap); Q9KCC7|MTRA|BH1646 from Bacillus halodurans (188 aa), FASTA scores: opt: 757,E(): 8.1e-41, (62.3% identity in 183 aa overlap); P19465|GCH1_BACSU|FOLE|MTRA from Bacillus subtilis (190 aa), FASTA scores: opt: 750, E(): 2.3e-40, (58.95% identity in 190 aa overlap); etc. Contains PS00860 GTP cyclohydrolase I signature 2. BELONGS TO THE GTP CYCLOHYDROLASE I FAMILY.	X2BPE3,P64208	No									X2BPE3,P64208	P64208									
NC_002945.3	Mycobrowser_v4	CDS	3997272	3997826	.	-	0	Mb3644c	espd		esx-1 secretion-associated protein espd	Mb3644c, -, len: 184 aa. Equivalent to Rv3614c,len: 184 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 184 aa overlap). Conserved hypothetical protein, equivalent to Q49730|ML0407|B1620_C3_264|MLCL383.03 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium leprae (216 aa) FASTA scores: opt: 899, E(): 1.7e-51, (71.3% identity in 188 aa overlap); and similar to two hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa), FASTA scores: opt: 285, E(): 1.2e-11, (38.35% identity in 172 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 289, E(): 1.2e-11, (38.95% identity in 172 aa overlap). Also highly similar to O69732|Rv3867|MTV027.02 HYPOTHETICAL 19.9 KDA PROTEIN from Mycobacterium tuberculosis (183 aa), FASTA scores: opt: 563, E(): 1e-29,(54.9% identity in 173 aa overlap).	Q7TW35	No	cell wall and cell processes								Q7TW35	A0A1R3Y4Q6				Rv3614c		Rv3614c			
NC_002945.3	Mycobrowser_v4	CDS	3997942	3998253	.	-	0	Mb3645c	espc		esx-1 secretion-associated protein espc	Mb3645c, -, len: 103 aa. Equivalent to Rv3615c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Conserved hypothetical protein, equivalent to Q49723|ML0406|B1620_C2_214|MLCL383 HYPOTHETICAL 11.1 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 364, E(): 4.1e-18, (60.85% identity in 92 aa overlap). Also shows similarity to P96212|Rv3865|MTCY01A6.03 HYPOTHETICAL 10.6 KDA PROTEIN from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 198, E(): 6.8e-07, (36.25% identity in 102 aa overlap).	X2BPX2	No	cell wall and cell processes								X2BPX2	P65088				Rv3615c		Rv3615c			
NC_002945.3	Mycobrowser_v4	CDS	3999971	4000486	.	+	0	Mb3647	lpqG		PROBABLE CONSERVED LIPOPROTEIN LPQG	Mb3647, lpqG, len: 171 aa. Equivalent to 3' end of Rv3623, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 171 aa overlap). Probable lpqG, conserved lipoprotein, showing some similarity with hypothetical proteins e.g. Q57432 from Methanosarcina barkeri (251 aa), FASTA scores: opt: 319,E(): 6.8e-12, (31.2% identity in 218 aa overlap); Q9PEA5|XF1123 OUTER MEMBRANE PROTEIN from Xylella fastidiosa (242 aa) FASTA scores: opt: 312, E(): 1.7e-11,(28.25% identity in 237 aa overlap); BAB49547|MLR2408 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (236 aa), FASTA scores: opt: 304, E(): 5e-11,(27.05% identity in 244 aa overlap); etc. Has suitable signal peptide and prokaryotic membrane lipoprotein lipid attachment site (PS00013). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 5894 bp deletion leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa).	Q7TW33	No								IPR007497	Q7TW33	A0A1R3Y6A5									
NC_002945.3	Mycobrowser_v4	CDS	4000491	4001141	.	-	0	Mb3648c	hpt		HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE HPT (HGPRT) (HGPRTase) (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE) (IMP PYROPHOSPHORYLASE) (IMP DIPHOSPHORYLASE) (TRANSPHOSPHORIBOSYLTRANSFERASE) (GUANINE PHOSPHORIBOSYLTRANSFERASE)	Mb3648c, hpt, len: 216 aa. Equivalent to Rv3624c,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). Probable hpt (alternate gene name: hprT), hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) (but seems to have a 35 aa extension at N-terminus), equivalent to other mycobacterial hypoxanthine-guanine phosphoribosyltransferases e.g. P96794 from Mycobacterium avium (203 aa), FASTA scores: opt: 1136, E(): 1.2e-65,(88.5% identity in 200 aa overlap); and O69537|HPT|ML0214 from Mycobacterium leprae (213 aa), FASTA scores: opt: 1115, E(): 2.8e-64, (81.6% identity in 212 aa overlap). Also similar to others e.g. Q9X8I5|SCE9.12c from Streptomyces coelicolor (187 aa), FASTA scores: opt: 724,E(): 2.4e-39, (60.55% identity in 180 aa overlap); P37472|HPRT_BACSU|HPT from Bacillus subtilis (180 aa) FASTA scores: opt: 574, E(): 9.1e-30, (48.6% identity in 181 aa overlap); etc. Equivalent to AAK48087 from Mycobacterium tuberculosis strain CDC1551 (202 aa) but longer 14 aa. Contains PS00103 Purine/pyrimidine phosphoribosyltransferases signature. BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY.	X2BNW2,P0A5T1	No									X2BNW2,P0A5T1	P0A5T1									
NC_002945.3	Mycobrowser_v4	CDS	4001138	4002109	.	-	0	Mb3649c	mesJ		POSSIBLE CELL CYCLE PROTEIN MESJ	Mb3649c, mesJ, len: 323 aa. Equivalent to Rv3625c,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Possible mesJ, cell cycle protein, equivalent to O69538|Y0C5_MYCLE|ML0213|MLCB2548.18c HYPOTHETICAL 34.1 KDA PROTEIN from Mycobacterium leprae (323 aa) FASTA scores: opt: 1592, E(): 9e-92, (78.0% identity in 327 aa overlap). Similar to bacterial hypothetical proteins Q9X8I6|SCE9.13c from Streptomyces coelicolor (352 aa) FASTA scores: opt: 705, E(): 1.4e-36, (47.85% identity in 305 aa overlap); and Q9HXZ3|PA3638 from Pseudomonas aeruginosa (442 aa), FASTA scores: opt: 382, E(): 2e-16,(40.6% identity in 271 aa overlap). But also similar (or with similarity) to bacterial cell cycle proteins (MESJ) e.g. Q9KPX0|VC2242 MESJ PROTEIN from Vibrio cholerae (440 aa), FASTA scores: opt: 363, E(): 3e-15, (34.8% identity in 253 aa overlap); Q9RV23|DR1207 (600 aa) CELL CYCLE PROTEIN MESJ (PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN) from Deinococcus radiodurans (600 aa), FASTA scores: opt: 310, E(): 7.6e-12, (36.6% identity in 265 aa overlap) (similar only at the N-terminal end); Q9PFJ8|XF0659 CELL CYCLE PROTEIN from Xylella fastidiosa (437 aa), FASTA scores: opt: 301, E(): 2.1e-11, (35.05% identity in 271 aa overlap); P52097|MESJ_ECOLI|B0188 PUTATIVE CELL CYCLE PROTEIN MESJ from Escherichia coli strain K12(432 aa) FASTA scores: opt: 299, E(): 2.8e-11, (34.65% identity in 277 aa overlap); etc. BELONGS TO THE UPF0072 (MESJ/YCF62) FAMILY.	X2BPE9,P67152	No									X2BPE9,P67152	P67152									
NC_002945.3	Mycobrowser_v4	CDS	4004660	4005148	.	+	0	Mb3652	ppa		INORGANIC PYROPHOSPHATASE PPA (PYROPHOSPHATE PHOSPHO-HYDROLASE) (PPASE) (INORGANIC DIPHOSPHATASE) (DIPHOSPHATE PHOSPHO-HYDROLASE)	Mb3652, ppa, len: 162 aa. Equivalent to Rv3628,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). ppa, inorganic pyrophosphatase (EC 3.6.1.1) (see first citation),identical to O69540|IPYR_MYCLEPPA|ML0210|MLCB2548.21 INORGANIC PYROPHOSPHATASE from Mycobacterium leprae (162 aa) FASTA scores: opt: 1018, E(): 1.3e-59, (89.5% identity in 162 aa overlap). Also highly similar to many bacterial pyrophosphatases e.g. Q9X8I9|IPYR_STRCO|PPA|SCE9.16 from Streptomyces coelicolor (163 aa), FASTA scores: opt: 773,E(): 1.3e-43, (67.5% identity in 163 aa overlap); O05545|IPYR_GLUOX|PPA from Gluconobacter oxydans (Gluconobacter suboxydans) (176 aa), FASTA scores: opt: 553, E(): 3.2e-29, (53.8% identity in 145 aa overlap); P77992|IPYR_THELI|PPA from Thermococcus litoralis (176 aa) FASTA scores: opt: 537, E(): 3.5e-28, (49.35% identity in 152 aa overlap); P50308|IPYR_SULAC|PPA from Sulfolobus acidocaldarius (173 aa), FASTA scores: opt: 518, E(): 6e-27, (45.3% identity in 159 aa overlap); etc. BELONGS TO THE PPASE FAMILY. COFACTOR: REQUIRES THE PRESENCE OF DIVALENT METAL CATION. MAGNESIUM CONFERS THE HIGHEST ACTIVITY. BINDS 4 DIVALENT CATIONS PER SUBUNIT (BY SIMILARITY).	X2BP74,P65747	No	intermediary metabolism and respiration								X2BP74,P65747	P65747				Rv3628		Rv3628			
NC_002945.3	Mycobrowser_v4	CDS	4009904	4010848	.	-	0	Mb3658c	galE1		UDP-GLUCOSE 4-EPIMERASE GALE1 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE)	Mb3658c, galE1, len: 314 aa. Equivalent to Rv3634c,len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 314 aa overlap). galE1, UDP-glucose 4-epimerase (EC 5.1.3.2) (see citations below), equivalent to O69544|ML0204|RMLB2|MLCB2548.27c PUTATIVE SUGAR DEHYDRATASE (PUTATIVE SUGAR-NUCLEOTIDE DEHYDRATASE) from Mycobacterium leprae (319 aa), FASTA scores: opt: 1798,E(): 8.2e-100, (86.4% identity in 309 aa overlap). Also similar to other UDP-GLUCOSE 4-EPIMERASES e.g. Q9WYX9|TM0509 from Thermotoga maritima (309 aa) FASTA scores: opt: 877, E(): 4.8e-45, (45.8% identity in 308 aa overlap); Q57664|GALE_METJA|MJ0211 from Methanococcus jannaschii (305 aa), FASTA scores: opt: 792, E(): 5.4e-40,(42.05% identity in 309 aa overlap); Q9K6S7|BH3649 from Bacillus halodurans (311 aa), FASTA scores: opt: 723, E(): 7e-36, (40.5% identity in 316 aa overlap); Q9HSV1|GALE2|VNG0063G from Halobacterium sp. strain NRC-1 (328 aa), FASTA scores: opt: 597, E(): 2.3e-28, (36.35% identity in 322 aa overlap); etc. Contains short-chain alcohol dehydrogenase family signature (PS00061) but this maynot be significant. BELONGS TO THE SUGAR EPIMERASE FAMILY. Note that previously known as rmlB2, a DTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (see third citation).	Q7TW27	No								IPR001509,IPR016040	Q7TW27	A0A1R3Y594									
NC_002945.3	Mycobrowser_v4	CDS	4041022	4041822	.	-	0	Mb3688c	dppC		PROBABLE DIPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DPPC	Mb3688c, dppC, len: 266 aa. Equivalent to Rv3664c,len: 266 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 266 aa overlap). Probable dppC,dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F351|SC9E12.04 PUTATIVE PEPTIDE TRANSPORT SYSTEM INTEGRAL MEMBRANE from Streptomyces coelicolor (305 aa), FASTA scores: opt: 901, E(): 1.1e-47,(51.15% identity in 262 aa overlap); Q9KFX1|APPC|BH0349 OLIGOPEPTIDE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (305 aa), FASTA scores: opt: 652, E(): 1.5e-32,(35.55% identity in 270 aa overlap); P94312|DPPC_BACFI DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus firmus (304 aa), FASTA scores: opt: 642, E(): 5.9e-32,(35.75% identity in 263 aa overlap); P24139|OPPC_BACSU|SPO0KC OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (305 aa), FASTA scores: opt: 637, E(): 1.2e-31, (37.4% identity in 262 aa overlap); P26904|DPPC_BACSU|DCIAC DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (320 aa),FASTA scores: opt: 621, E(): 1.2e-30, (39.9% identity in 263 aa overlap); etc. HAS SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS. BELONGS TO THE OPPBC SUBFAMILY.	Q7TVZ9	No								IPR000515	Q7TVZ9	A0A1R3Y5A6									
NC_002945.3	Mycobrowser_v4	CDS	4017162	4017797	.	-	0	Mb3665c	fic		POSSIBLE CELL FILAMENTATION PROTEIN FIC	Mb3665c, fic, len: 211 aa. Equivalent to Rv3641c,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 211 aa overlap). Possible fic, cell filamentation protein, similar to others e.g. Q9PCU8|XF1657 CELL FILAMENTATION PROTEIN from Xylella fastidiosa (203 aa), FASTA scores: opt: 324, E(): 2.2e-14,(32.8% identity in 189 aa overlap); P20605|FIC_ECOLI|B3361 from Escherichia coli strain K12 (200 aa), FASTA scores: opt: 323, E(): 2.5e-14, (31.0% identity in 187 aa overlap); P20751|FIC_SALTY from Salmonella typhimurium (200 aa), FASTA scores: opt: 322, E(): 2.9e-14, (32.65% identity in 193 aa overlap); etc.	Q7TW20	No								IPR003812	Q7TW20	A0A1R3Y4S8									
NC_002945.3	Mycobrowser_v4	CDS	4021690	4024494	.	-	0	Mb3670c	topA		dna topoisomerase i topa (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type i dna topoisomerase) (nicking-closing enzyme) (topo i)	Mb3670c, topA, len: 934 aa. Equivalent to Rv3646c,len: 934 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 934 aa overlap). topA, DNA topoisomerase I (EC 5.99.1.2) (see citation below),equivalent to O69548|TOP1_MYCLE|TOPA|ML0200|MLCB2548.31c DNA TOPOISOMERASE I from Mycobacterium leprae (947 aa) FASTA scores: opt: 5150, E(): 0, (84.6% identity in 936 aa overlap). Also highly similar to many e.g. Q9X909|TOP1_STRCO|TOPA|SCH5.06c from Streptomyces coelicolor (952 aa), FASTA scores: opt: 2754, E(): 1.3e-153, (61.3% identity in 928 aa overlap); P73810|TOP1_SYNY3|TOPA|SLR2058 from Synechocystis sp. strain PCC 6803 (898 aa), FASTA scores: opt: 1442, E(): 9.1e-77, (47.15% identity in 927 aa overlap); P47368|TOP1_MYCGE|TOPA|MG122 from Mycoplasma genitalium (709 aa), FASTA scores: opt: 865, E(): 4.8e-43, (30.3% identity in 736 aa overlap); P06612|TOP1_ECOLI|TOPA|SUPX|B1274 from Escherichia coli strain K12 (865 aa), FASTA scores: opt: 397, E(): 0,(39.6% identity in 704 aa overlap); etc. BELONGS TO PROKARYOTIC TYPE I/III TOPOISOMERASE FAMILY.	X2BPY1,P0A621	No									X2BPY1,P0A621	P0A621									
NC_002945.3	Mycobrowser_v4	CDS	4025565	4025768	.	-	0	Mb3672c	cspA		PROBABLE COLD SHOCK PROTEIN A CSPA	Mb3672c, cspA, len: 67 aa. Equivalent to Rv3648c,len: 67 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 67 aa overlap). Probable cspA, cold shock protein A, identical to O69550|CSPB|CSPA|ML0198 SMALL COLD-SHOCK PROTEIN from Mycobacterium leprae (67 aa) FASTA scores: opt: 451, E(): 3.7e-27, (97.0% identity in 67 aa overlap). Also highly similar to many e.g. Q9KGW0|CSPA from Mycobacterium smegmatis (67 aa) FASTA scores: opt: 439, E(): 2.9e-26, (92.55% identity in 67 aa overlap); P54584|CSP_ARTGO from Arthrobacter globiformis (67 aa), FASTA scores: opt: 335, E(): 1.5e-18, (73.45% identity in 64 aa overlap); O30875|CSPA_MICLU from Micrococcus luteus (Micrococcus lysodeikticus); Q9Z5R4|CSPA_BORPE from Bordetella pertussis (67 aa) FASTA scores: opt: 294, E(): 1.7e-15, (59.7% identity in 67 aa overlap); etc. Contains 'cold-shock' DNA-binding domain signature (PS00352) at N-terminal end. BELONGS TO THE COLD-SHOCK DOMAIN (CSD) FAMILY.	X2BP88,P63849	No									X2BP88,P63849	P63849									
NC_002945.3	Mycobrowser_v4	CDS	4039379	4041025	.	-	0	Mb3687c	dppD		PROBABLE DIPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DPPD	Mb3687c, dppD, len: 548 aa. Equivalent to Rv3663c,len: 548 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 548 aa overlap). Probable dppD,dipeptide-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. AAK65441|SMA1434 PROBABLE ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (550 aa), FASTA scores: opt: 1528, E(): 1e-78, (46.25% identity in 545 aa overlap); O50270|MOAD MOAD PROTEIN from Agrobacterium radiobacter (588 aa),FASTA scores: opt: 1354, E(): 6.7e-69, (42.9% identity in 541 aa overlap); Q9KM01|VCA0588 PUTATIVE PEPTIDE ABC TRANSPORTER ATP-BINDING PROTEIN from Vibrio cholerae (530 aa), FASTA scores: opt: 951, E(): 3.1e-46, (44.0% identity in 534 aa overlap); BAB49448|MLR2279 ATP-BINDING PROTEIN OF PEPTIDE ABC TRANSPORTER from Rhizobium loti (Mesorhizobium loti) (604 aa), FASTA scores: opt: 949,E(): 4.4e-46, (41.55% identity in 544 aa overlap); etc. Contains 2 PS00211 ABC transporters family signature, and 2 PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TW00	No								IPR003439,IPR003593,IPR013563,IPR017871,IPR027417	Q7TW00	A0A1R3Y6D0									
NC_002945.3	Mycobrowser_v4	CDS	4028470	4028754	.	+	0	Mb3674	PE33		pe family protein pe33	Mb3674, PE33, len: 94 aa. Equivalent to Rv3650,len: 94 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 94 aa overlap). Short protein, member of the Mycobacterium tuberculosis PE family, but without the repetitive gly-rich region, similar to the N-terminal part of many e.g. O53809|Rv0746|MTV041.20 PGRS-FAMILY PROTEIN (783 aa), FASTA scores: opt: 363, E(): 2.1e-15,(76.55% identity in 81 aa overlap).	Q7TW13	No	PE/PPE							IPR000084	Q7TW13	A0A1R3Y4S3				Rv3650		Rv3650			
NC_002945.3	Mycobrowser_v4	CDS	4041878	4042804	.	-	0	Mb3689c	dppB		PROBABLE DIPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DPPB	Mb3689c, dppB, len: 308 aa. Equivalent to Rv3665c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 308 aa overlap). Probable dppB,dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F352|SC9E12.03 PUTATIVE PEPTIDE TRANSPORT SYSTEM INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (307 aa), FASTA scores: opt: 1145,E(): 1.8e-61, (57.65% identity in 307 aa overlap); Q53191|Y4TP_RHISN PROBABLE PEPTIDE ABC TRANSPORTER PERMEASE PROTEIN Rhizobium sp. strain NGR234 (313 aa),FASTA scores: opt: 653, E(): 5.2e-32, (31.2% identity in 314 aa overlap); P24138|OPPB_BACSU OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE from Bacillus subtilis (311 aa), FASTA scores: opt: 643, E(): 2.1e-31, (33.45% identity in 305 aa overlap); etc. BELONGS TO THE OPPBC SUBFAMILY.	Q7TVZ8	No								IPR000515	Q7TVZ8	A0A1R3Y4U9									
NC_002945.3	Mycobrowser_v4	CDS	4042806	4044431	.	-	0	Mb3690c	dppA		PROBABLE PERIPLASMIC DIPEPTIDE-BINDING LIPOPROTEIN DPPA	Mb3690c, dppA, len: 541 aa. Equivalent to Rv3666c,len: 541 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 541 aa overlap). Probable dppA,dipeptide-binding lipoprotein component of dipeptide transport system (see citation below), similar to many substrate-binding proteins e.g. Q9F353|SC9E12.02 PUTATIVE PEPTIDE TRANSPORT SYSTEM SECRETED PEPTIDE-BINDING PROTEIN from Streptomyces coelicolor (544 aa), FASTA scores: opt: 1200, E(): 9e-67, (39.2% identity in 538 aa overlap); P24141|OPPA_BACSU OLIGOPEPTIDE-BINDING PROTEIN from Bacillus subtilis (545 aa), FASTA scores: opt: 523, E(): 7.9e-25, (26.15% identity in 516 aa overlap); P23843|OPPA_ECOLI PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN from Escherichia coli (543 aa), FASTA scores: opt: 452,E(): 2e-20, (25.9% identity in 529 aa overlap); etc. Contains probable N-terminal signal sequence.	Q7TVZ7	No								IPR000914	Q7TVZ7	A0A1R3Y4X4									
NC_002945.3	Mycobrowser_v4	CDS	4045139	4047094	.	+	0	Mb3691	acs		ACETYL-COENZYME A SYNTHETASE ACS (ACETATE--CoA LIGASE) (ACETYL-CoA SYNTHETASE) (ACETYL-CoA SYNTHASE) (ACYL-ACTIVATING ENZYME) (ACETATE THIOKINASE) (ACETYL-ACTIVATING ENZYME) (ACETATE--COENZYME A LIGASE) (ACETYL-COENZYME A SYNTHASE)	Mb3691, acs, len: 651 aa. Equivalent to Rv3667,len: 651 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 651 aa overlap). Probable acs,acetyl-coenzyme-A synthetase (EC 6.2.1.1), similar to many e.g. Q9X928|SCH5.26 from Streptomyces coelicolor (651 aa) FASTA scores: opt: 2850, E(): 1.9e-164, (66.05% identity in 639 aa overlap); Q55404|ACSA_SYNY3|ACS|SLL0542 from Synechocystis sp. strain PCC 6803 (653 aa), FASTA scores: opt: 2342, E(): 8.8e-134, (55.15% identity in 649 aa overlap); P31638|ACSA_ALCEU|ACOE from Alcaligenes eutrophus (Ralstonia eutropha) (660 aa), FASTA scores: opt: 2181, E(): 4.6e-124, (52.05% identity in 665 aa overlap); P27550|ACSA_ECOLI|ACS|B4069 from Escherichia coli strain K12 (652 aa), FASTA scores: opt: 1625, E(): 0,(48.3% identity in 646 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.	X2BNU6,P59871	No	lipid metabolism								X2BNU6,P59871	P59871				Rv3667		Rv3667			
NC_002945.3	Mycobrowser_v4	CDS	4048693	4049676	.	+	0	Mb3694	ephE		POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)	Mb3694, ephE, len: 327 aa. Equivalent to Rv3670,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 327 aa overlap). Possible ephE,epoxide hydrolase (EC 3.3.2.3) (see citation below),equivalent to Q9CB96|ML2297 PUTATIVE HYDROLASE from Mycobacterium leprae (324 aa), FASTA scores: opt: 1799,E(): 7.2e-105, (80.55% identity in 324 aa overlap). Also similar to many hydrolases (epoxide hydrolases) and hypothetical proteins e.g. Q9X931|SCH5.29 PUTATIVE HYDROLASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 687, E(): 1.4e-35, (40.65% identity in 327 aa overlap); Q9RRE3|DR2549 EPOXIDE HYDROLASE-RELATED PROTEIN from Deinococcus radiodurans (278 aa), FASTA scores: opt: 321, E(): 8.2e-13, (32.15% identity in 311 aa overlap); Q9K3Q1|2SCG4.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (292 aa), FASTA scores: opt: 295, E(): 3.5e-11,(30.18% identity in 275 aa overlap); Q9S7P1 EPOXIDE HYDROLASE from Oryza sativa (Rice) (322 aa), FASTA scores: opt: 289, E(): 9.1e-11, (28.7% identity in 338 aa overlap); O23227|C7A10.830|AT4G36530 EPOXIDE HYDROLASE from Arabidopsis thaliana (Mouse-ear cress) (378 aa) FASTA scores: opt: 287, E(): 1.4e-10, (26.1% identity in 272 aa overlap); Q21147|K02F3.6 EPOXIDE HYDROLASE from Caenorhabditis elegans (386 aa), FASTA scores: opt: 283,E(): 2.5e-10, (33.35% identity in 156 aa overlap); etc. Also similar to P95276|EPHB|Rv1938|MTCY09F9.26c from Mycobacterium tuberculosis (356 aa), FASTA scores: opt: 296, E(): 3.6e-11, (29.7% identity in 340 aa overlap). Contains PS00213 Lipocalin signature. SIMILAR TO ALPHA/BETA HYDROLASE FOLD.	Q7TVZ4	No	virulence, detoxification, adaptation							IPR000639	Q7TVZ4	A0A1R3Y4U4				Rv3670		Rv3670			
NC_002945.3	Mycobrowser_v4	CDS	4077587	4077811	.	-	0	Mb3723A	vapB48		Possible antitoxin VapB48	Mb3723A, len: 74 aa. Equivalent to Rv3697A len: 74 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB48,antitoxin,part of toxin-antitoxin (TA) operon with Rv3697c, see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. Rv3321c, Rv0748	X2BPK9	No	virulence, detoxification, adaptation								X2BPK9	A0A1R3Y4Y9				Rv3697A		Rv3697A			
NC_002945.3	Mycobrowser_v4	CDS	4052504	4053241	.	-	0	Mb3698c	nth		PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC SITE)LYASE) (AP LYASE) (AP ENDONUCLEASE CLASS I) (ENDODEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) (DEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC))	Mb3698c, nth, len: 245 aa. Equivalent to Rv3674c,len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 245 aa overlap). Probable nth,endonuclease III (EC 4.2.99.18), equivalent to Q9CB92|NTH|ML2301 PUTATIVE ENDONUCLEASE III from Mycobacterium leprae (272 aa), FASTA scores: opt: 1363,E(): 3.6e-81, (89.4% identity in 226 aa overlap). Also similar to many e.g. Q9XA44|SCH17.03c from Streptomyces coelicolor (250 aa), FASTA scores: opt: 937, E(): 2.2e-55,(61.65% identity in 219 aa overlap); P46303|UVEN_MICLU from Micrococcus luteus (Micrococcus lysodeikticus) (279 aa), FASTA scores: opt: 899, E(): 8.1e-53, (58.45% identity in 248 aa overlap); P73715|END3_SYNY3|NTH|SLR1822 from Synechocystis sp. strain PCC 6803 (219 aa), FASTA scores: opt: 684, E(): 1.7e-38, (52.2% identity in 203 aa overlap); P39788|END3_BACSU|NTH|JOOB from Bacillus subtilis (219 aa), FASTA scores: opt: 552, E(): 1.2e-29,(43.3% identity in 194 aa overlap); etc. Equivalent to AAK48142 from Mycobacterium tuberculosis strain CDC1551 (262 aa) but shorter 17 aa. Contains PS00764 Endonuclease III iron-sulfur binding region signature, and PS01155 Endonuclease III family signature. BELONGS TO THE NTH/MUTY FAMILY. COFACTOR: BINDS A 4FE-4S CLUSTER WHICH IS NOT IMPORTANT FOR THE CATALYTIC ACTIVITY, BUT WHICH IS PROBABLY INVOLVED IN THE PROPER POSITIONING OF THE ENZYME ALONG THE DNA STRAND (BY SIMILARITY). N-terminus extended since first submission (previously 226 aa).	X2BP01,P63541	No									X2BP01,P63541	P63541									
NC_002945.3	Mycobrowser_v4	CDS	4131734	4132096	.	+	0	Mb3770	nmtr		metal sensor transcriptional regulator (arsr-smtb family)	Mb3770, -, len: 120 aa. Equivalent to Rv3744, len: 120 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 120 aa overlap). Probable transcriptional regulator, possible arsR family, highly similar to many e.g. Q9ZBF4|SC9B5.26c from Streptomyces coelicolor (120 aa), FASTA scores: opt: 480, E(): 2.4e-24,(63.25% identity in 117 aa overlap); O31844|YOZA YOZA REGULATOR from Bacillus subtilis (107 aa), FASTA scores: opt: 249, E(): 1.6e-09, (44.8% identity in 96 aa overlap); P30340|SMTB_SYNP7|SMTB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (122 aa), FASTA scores: opt: 230, E(): 2.9e-08, (46.0% identity in 87 aa overlap); etc. Equivalent to AAK48216 from Mycobacterium tuberculosis strain CDC1551 (135 aa) but shorter 15 aa. Also similar to MTCY27_22; MTCY39_25; and MTCY441_12. Contains helix-turn-helix motif at aa 47-68 (Score 1815, +5.37 SD). SEEMS TO BELONG TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TVS9	No	regulatory proteins							IPR001845,IPR011991	Q7TVS9	A0A1R3Y562				Rv3744		Rv3744			
NC_002945.3	Mycobrowser_v4	CDS	4053825	4054499	.	+	0	Mb3700	crp		transcriptional regulatory protein crp (crp/fnr-family)	Mb3700, -, len: 224 aa. Equivalent to Rv3676, len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Probable transcriptional regulator belonging to crp/fnr family,identical to Q9CB91|ML2302 PUTATIVE CRP/FNR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (224 aa), FASTA scores: opt: 1408, E(): 8.8e-81, (95.95% identity in 224 aa overlap). Also highly similar to transcriptional regulators AAK58838 from Corynebacterium glutamicum (Brevibacterium flavum) (227 aa), FASTA scores: opt: 1178, E(): 1.9e-66, (79.9% identity in 224 aa overlap); and Q9XA42|SCH17.05 from Streptomyces coelicolor (224 aa), FASTA scores: opt: 869, E(): 3.4e-47, (54.45% identity in 224 aa overlap); and similar to others e.g. Q9RRX0|DR2362 from Deinococcus radiodurans (231 aa) FASTA scores: opt: 344, E(): 1.8e-14, (30.8% identity in 211 aa overlap); P29281|CRP_HAEIN from Haemophilus influenzae (224 aa), FASTA scores: opt: 330, E(): 1.3e-13, (32.25% identity in 189 aa overlap); P03020|CRP_ECOLI|CAP|CSM|B3357 from Escherichia coli strain K12 and Shigella flexneri (210 aa), FASTA scores: opt: 323, E(): 3.5e-13, (32.25% identity in 189 aa overlap); etc. Contains helix-turn-helix motif at aa 175-196 (Score 1990, +5.96 SD). BELONGS TO THE CRP/FNR FAMILY OF TRANSCRIPTIONAL REGULATORS.	Q7TVY9	No	regulatory proteins							IPR000595,IPR001808,IPR011991,IPR012318,IPR014710,IPR018490	Q7TVY9	A0A1R3Y4Y5				Rv3676		Rv3676			
NC_002945.3	Mycobrowser_v4	CDS	4064642	4066072	.	-	0	Mb3710c	cyp137		PROBABLE CYTOCHROME P450 137 CYP137	Mb3710c, cyp137, len: 476 aa. Equivalent to Rv3685c, len: 476 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 476 aa overlap). Probable cyp137, cytochrome P-450 (EC 1.14.-.-), similar to many e.g. Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila melanogaster (Fruit fly) (495 aa), FASTA scores: opt: 376,E(): 1.2e-15, (28.35% identity in 413 aa overlap); Q59163|CYP110A2 from Anabaena variabilis (459 aa) FASTA scores: opt: 320, E(): 3.1e-12, (31.4% identity in 411 aa overlap); O23051|C883_ARATH from Arabidopsis thaliana (Mouse-ear cress) (490 aa), FASTA scores: opt: 313, E(): 8.8e-12, (28.25% identity in 425 aa overlap); etc. Also similar to many from Mycobacterium tuberculosis e.g. O53765|C13B_MYCTU|CYP135B1|Rv0568|MT0594|MTV039.06 (472 aa), FASTA scores: opt: 920, E(): 4.6e-49, (36.25% identity in 447 aa overlap); P96813|C138_MYCTU|CYP138|Rv0136|MT0144|MTCI5.10 (441 aa) FASTA scores: opt: 886, E(): 5.3e-47, (35.5% identity in 445 aa overlap); etc. BELONGS TO THE CYTOCHROME P450 FAMILY.	Q7TVY0	No	intermediary metabolism and respiration							IPR001128,IPR002401,IPR017972	Q7TVY0	A0A1R3Y4Z7				Rv3685c		Rv3685c			
NC_002945.3	Mycobrowser_v4	CDS	4075549	4076529	.	-	0	Mb3721c	glpKb		PROBABLE GLYCEROL KINASE GLPKB [SECOND PART] (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK)	Mb3721c, glpKb, len: 326 aa. Equivalent to 3' end of Rv3696c, len: 517 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 326 aa overlap). Probable glpK, glycerol kinase (EC 2.7.1.30), equivalent to Q9CB81|GLPK_MYCLE|ML2314 GLYCEROL KINASE from Mycobacterium leprae (508 aa), FASTA scores: opt: 3120,E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606,E(): 1.1e-156, (75.35% identity in 503 aa overlap); Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503 aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa), FASTA scores: opt: 1838, E(): 2.7e-108,(54.8% identity in 498 aa overlap); P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3% identity in 499 aa overlap); etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1, PS00070 Aldehyde dehydrogenases cysteine active site, PS00445 FGGY family of carbohydrate kinases signature 2. BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, glpK exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g), splits glpK into 2 parts, glpKa and glpKb and removes activity.		No																			
NC_002945.3	Mycobrowser_v4	CDS	4097349	4097960	.	-	0	Mb3742c	recR		probable recombination protein recr	Mb3742c, recR, len: 203 aa. Equivalent to Rv3715c,len: 203 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 203 aa overlap). Probable recR,recombination protein, equivalent to O69520|RECR_MYCLE|ML2329|MLCB2407.21 RECOMBINATION PROTEIN from Mycobacterium leprae (203 aa), FASTA scores: opt: 1246, E(): 9.2e-71, (91.6% identity in 202 aa overlap). Also highly similar to many e.g. Q9XAI4|RECR_STRCO|SC66T3.29c from Streptomyces coelicolor (199 aa), FASTA scores: opt: 952, E(): 1.9e-52, (68.3% identity in 202 aa overlap); P24277|RECR_BACSU|RECM|RECD from Bacillus subtilis (198 aa), FASTA scores: opt: 696,E(): 1.8e-36, (50.5% identity in 198 aa overlap); Q9ZNA2|RECR_DEIRA|DR0198 from Deinococcus radiodurans (220 aa), FASTA scores: opt: 673, E(): 5.2e-35, (49.75% identity in 195 aa overlap); etc. BELONGS TO THE RECR FAMILY.	X2BP52,P65991	No									X2BP52,P65991	P65991									
NC_002945.3	Mycobrowser_v4	CDS	4066670	4066915	.	-	0	Mb3712c	rsfb		anti-anti-sigma factor rsfb (anti-sigma factor antagonist) (regulator of sigma f b)	Mb3712c, -, len: 81 aa. Equivalent to Rv3687c, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Hypothetical protein,showing some similarity to sporulation proteins and sigma-factor genes e.g. Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa) FASTA scores: opt: 163, E(): 0.0007,(31.15% identity in 106 aa overlap); Q9F3A2|SC5F1.27c PUTATIVE ANTI-SIGMA FACTOR ANTAGONIST from Streptomyces coelicolor (114 aa) FASTA scores: opt: 159, E(): 0.0013,(29.8% identity in 104 aa overlap); P73609|SLR1859 HYPOTHETICAL 12.0 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (108 aa) FASTA scores: opt: 152, E(): 0.0034, (32.2% identity in 90 aa overlap); L47358|BACSPOI_1 spoIIA A from Paenibacillus polymyxa (117 aa), FASTA scores: opt: 107, E(): 0.23, (24.8% identity in 113 aa overlap); SQSIGB_4 rsbU, rsbV, rsbW & sigB genes from Steptomyces aureus (108 aa) (28.3% identity in 60 aa overlap); etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. MTCY180_14 and MTCY441 _8. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation at the 5' start due to a single base transversion (g-t) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa).	Q7TVX8	No	information pathways							IPR002645	Q7TVX8	A0A1R3Y4V0				Rv3687c		Rv3687c			
NC_002945.3	Mycobrowser_v4	CDS	4058545	4058901	.	-	0	Mb3706c	whiB4		probable transcriptional regulatory protein whib-like whib4	Mb3706c, whiB4, len: 118 aa. Equivalent to Rv3681c,len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 118 aa overlap). Probable whiB4,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to ML2307 HYPOTHETICAL PROTEIN from Mycobacterium leprae (116 aa). Also highly similar to Q9S2B9|SCH17.13c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 392,E(): 1e-20, (67.95% identity in 78 aa overlap); Q9X951|WBLA HYPOTHETICAL 14.3 KDA PROTEIN from Streptomyces coelicolor (129 aa), FASTA scores: opt: 392,E(): 1.1e-20, (67.95% identity in 78 aa overlap); Q9ACZ0|SCP1.161c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (268 aa), FASTA scores: opt: 273,E(): 4.4e-12, (50.0% identity in 78 aa overlap); Q06387|WHIB-STV from Streptomyces griseocarneus (87 aa) FASTA scores: opt: 231, E(): 1.5e-09, (43.85% identity in 73 aa overlap); etc. Also similar to several putative regulator proteins from Mycobacterium tuberculosis e.g. MTCY7D11_7; MTCY78_13; MTCY10H4_23; MTCY1A6_6; and U00016_29 from M. leprae. N-terminus shortened since first submission.	Q7TVY4	No								IPR003482	Q7TVY4	A0A1R3Y4W3									
NC_002945.3	Mycobrowser_v4	CDS	4059263	4061695	.	+	0	Mb3707	ponA2		PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)]	Mb3707, ponA2, len: 810 aa. Equivalent to Rv3682,len: 810 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 810 aa overlap). Probable ponA2,penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities. Almost identical to Q9CB85|PON1|ML2308 PENICILLIN BINDING PROTEIN (CLASS A) from Mycobacterium leprae (803 aa) FASTA scores: opt: 4743, E(): 3.3e-217, (87.7% identity in 806 aa overlap); or P72351|PON1|PBP1 HIGH-MOLECULAR-MASS CLASS A PENICILLIN BINDING PROTEIN from Mycobacterium leprae Cosmid B577 (821 aa), FASTA scores: opt: 4547, E(): 6.3e-208, (88.05% identity in 769 aa overlap) (see first citation below). Also similar to others e.g. Q9XA34|SCH17.14 from Streptomyces coelicolor (428 aa; fragment), FASTA scores: opt: 727, E(): 2.3e-27, (36.55% identity in 413 aa overlap); Q9F9V7|PONA from Mycobacterium smegmatis (715 aa), FASTA scores: opt: 446,E(): 6.6e-14, (27.65% identity in 771 aa overlap) (see second citation below); Q9CCY4|PONA|ML2688 from Mycobacterium leprae (708 aa), FASTA scores: opt: 413,E(): 2.4e-12, (26.8% identity in 660 aa overlap); Q9X6W0|PONB|MRCB|PA4700 from Pseudomonas aeruginosa (774 aa), FASTA scores: opt: 398, E(): 1.3e-11, (27.2% identity in 666 aa overlap); P45345|PBPB_HAEIN|MRCB|PONB|HI1725 (781 aa), FASTA scores: opt: 380, E(): 9.4e-11, (28.6% identity in 601 aa overlap); etc. Also similar to P71707|PONA1|Rv0050|MTCY21.13 PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B (PBP1) from M. tuberculosis (678 aa) FASTA scores: opt: 372, E(): 2e-10,(28.35% identity in 769 aa overlap). SEEMS TO BELONG TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION.	Q7TVY3	No								IPR001264,IPR001460,IPR005543,IPR012338,IPR023346	Q7TVY3	A0A1R3Y6G6									
NC_002945.3	Mycobrowser_v4	CDS	4070863	4071939	.	+	0	Mb3717	moxR2		probable methanol dehydrogenase transcriptional regulatory protein moxr2	Mb3717, moxR2, len: 358 aa. Equivalent to Rv3692,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 358 aa overlap). Probable moxR2,methanol dehydrogenase regulatory protein, highly similar (generally longer at N-terminus) to Q9KYW3|SCE33.20 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (329 aa), FASTA scores: opt: 1523, E(): 4.2e-74, (70.9% identity in 330 aa overlap); Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa) FASTA scores: opt: 1008, E(): 1.1e-46, (50.8% identity in 313 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 989, E(): 1.1e-45, (50.65% identity in 302 aa overlap); Q9AAN1|CC0566 MOXR PROTEIN from Caulobacter crescentus (323 aa), FASTA scores: opt: 988, E(): 1.3e-45, (52.3% identity in 306 aa overlap); etc. Also similar to O53170|MTV007.26|MOXR|Rv1479 from Mycobacterium tuberculosis (377 aa); and O07392|AF002133_6|MOXR from Mycobacterium avium (309 aa). Also high similarity with several hypothetical bacterial proteins.	Q7TVX3	No								IPR011703,IPR016366,IPR027417	Q7TVX3	A0A1R3Y6H5									
NC_002945.3	Mycobrowser_v4	CDS	4093259	4094248	.	-	0	Mb3738c	dnaQ		probable dna polymerase iii (epsilon subunit) dnaq	Mb3738c, dnaQ, len: 329 aa. Equivalent to Rv3711c,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 329 aa overlap). Probable dnaQ, DNA polymerase III, epsilon subunit (EC 2.7.7.7), similar to many e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328 aa), FASTA scores: opt: 509, E(): 4.2e-25, (41.6% identity in 315 aa overlap); Q9JYS6|NMB1451 from Neisseria meningitidis (serogroup B) (and Q9JTR5|MA1665 from serogroup A) (470 aa), FASTA scores: opt: 247, E(): 2.6e-08, (33.15% identity in 172 aa overlap); O83649|DP3E_TREPA|DNAQ|TP0643 from Treponema pallidum (215 aa), FASTA scores: opt: 240, E(): 3.7e-08, (29.65% identity in 162 aa overlap); P03007|DP3E_ECOLI|MUTD|B0215 from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 208, E(): 4.5e-06, (28.4% identity in 169 aa overlap); etc. Also similar to Q10384|YL91_MYCTU|Rv2191|MTCY190.02 from Mycobacterium tuberculosis (645 aa), FASTA scores: opt: 260, E(): 5e-09,(28.55% identity in 301 aa overlap).	Q7TVV5	No								IPR001357,IPR006054,IPR006055,IPR012337,IPR013520	Q7TVV5	A0A1R3Y4Y4									
NC_002945.3	Mycobrowser_v4	CDS	4076348	4077103	.	-	0	Mb3722c	glpKa		PROBABLE GLYCEROL KINASE GLPKA [FIRST PART] (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK)	Mb3722c, glpKa, len: 251 aa. Equivalent to 5' end of Rv3696c, len: 517 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 191 aa overlap). Probable glpK, glycerol kinase (EC 2.7.1.30), equivalent to Q9CB81|GLPK_MYCLE|ML2314 GLYCEROL KINASE from Mycobacterium leprae (508 aa), FASTA scores: opt: 3120,E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606,E(): 1.1e-156, (75.35% identity in 503 aa overlap); Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503 aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa), FASTA scores: opt: 1838, E(): 2.7e-108,(54.8% identity in 498 aa overlap); P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3% identity in 499 aa overlap); etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1, PS00070 Aldehyde dehydrogenases cysteine active site, PS00445 FGGY family of carbohydrate kinases signature 2. BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, glpK exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g), splits glpK into 2 parts, glpKa and glpKb and removes activity.	Q7TVW9	No								IPR018483,IPR018484	Q7TVW9	A0A1R3Y4V7									
NC_002945.3	Mycobrowser_v4	CDS	4077153	4077590	.	-	0	Mb3723c	vapc48		possible toxin vapc48. contains pin domain.	Mb3723c, -, len: 145 aa. Equivalent to Rv3697c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 145 aa overlap). Possible conserved membrane protein, similar to many proteins from Mycobacterium tuberculosis e.g. Q10800|YS72_MYCTU|Rv2872|MT2939|MTCY274.03 (147 aa) FASTA scores: opt: 223, E(): 7.3e-08, (32.6% identity in 141 aa overlap); O53501|Rv2103c|MTV020.03 (144 aa), FASTA scores: opt: 215, E(): 2.4e-07, (31.4% identity in 137 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 192, E(): 7.6e-06, (31.25% identity in 144 aa overlap); etc.	Q7TVW8	No	virulence, detoxification, adaptation							IPR002716,IPR006226,IPR022907	Q7TVW8	A0A1R3Y4X2				Rv3697c		Rv3697c			
NC_002945.3	Mycobrowser_v4	CDS	4084236	4085534	.	-	0	Mb3730c	gshA		GLUTAMATE--CYSTEINE LIGASE GSHA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE)	Mb3730c, gshA, len: 432 aa. Equivalent to Rv3704c,len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Possible gshA,glutamate--cysteine ligase (EC 6.3.2.2), similar to many e.g. Q9A2Z2|CC3414 GLUTAMATE--CYSTEINE LIGASE from Caulobacter crescentus (453 aa), FASTA scores: opt: 404,E(): 5.9e-17, (30.45% identity in 312 aa overlap); Q9SEH0|GSH1 GAMMA-GLUTAMYLCYSTEINYL SYNTHETASE PRECURSOR from Pisum sativum (Garden pea) (499 aa), FASTA scores: opt: 400, E(): 1.1e-16, (26.4% identity in 439 aa overlap); Q9RH09|GSH GAMMA-GLUTAMYLCYSTEINE SYNTHETASE from Zymomonas mobilis (462 aa), FASTA scores: opt: 397,E(): 1.6e-16, (28.95% identity in 304 aa overlap); P46309|GSH1_ARATH|GSH1|AT4G23100|F7H19.290 GLUTAMATE--CYSTEINE LIGASE from Arabidopsis thaliana (Mouse-ear cress) (522 aa), FASTA scores: opt: 395, E(): 2.3e-16, (27.25% identity in 385 aa overlap); etc. But note that this putative protein is also similar to Q9JMV4|GSHA PUTATIVE GLUTATHIONE SYNTHETASE (FRAGMENT) from Bradyrhizobium japonicum (460 aa), FASTA scores: opt: 498, E(): 1.3e-22, (33.35% identity in 333 aa overlap) (no significant publications found (August 2001).	Q7TVW1	No								IPR006336,IPR017809	Q7TVW1	A0A1R3Y503									
NC_002945.3	Mycobrowser_v4	CDS	4182809	4186105	.	+	0	Mb3824	embB		INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBB (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE)	Mb3824, embB, len: 1098 aa. Equivalent to Rv3795,len: 1098 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1098 aa overlap). embB, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below),equivalent to P71486|EMBB ARABINOSYL TRANSFERASE from Mycobacterium avium (1065 aa), FASTA scores: opt: 4998,E(): 0, (83.25% identity in 1076 aa overlap); Q9CDA9|EMBB|ML0104 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1083 aa), FASTA scores: opt: 4706,E(): 0, (78.0% identity in 1101 aa overlap); O30406|EMBB (alias Q50395) PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1082 aa), FASTA scores: opt: 4163, E(): 0, (68.4% identity in 1091 aa overlap); etc. Also similar to Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 2482, E(): 5e-135, (44.7% identity in 1101 aa overlap); Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa), FASTA scores: opt: 2259, E(): 3.4e-122, (43.4% identity in 1104 aa overlap); etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 2276, E(): 3.6e-123, (44.45% identity in 1118 aa overlap); and P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1288, E(): 2.5e-66, (42.35% identity in 1114 aa overlap). Supposed regulated by embR|Rv1267c.	X2BQ26,Q7TVN3	No									X2BQ26,Q7TVN3	Q7TVN3									
NC_002945.3	Mycobrowser_v4	CDS	4088528	4089565	.	-	0	Mb3735c	asd		ASPARTATE-SEMIALDEHYDE DEHYDROGENASE ASD (ASA DEHYDROGENASE) (ASADH) (ASPARTIC SEMIALDEHYDE DEHYDROGENASE) (L-ASPARTATE-BETA-SEMIALDEHYDE DEHYDROGENASE)	Mb3735c, asd, len: 345 aa. Equivalent to Rv3708c,len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 345 aa overlap). asd,aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) (see citation below), equivalent to many e.g. P47730|DHAS_MYCBO|ASD from Mycobacterium bovis (345 aa) FASTA scores: opt: 2150, E(): 1.6e-124, (97.7% identity in 345 aa overlap); or Q9JN40|ASD from Mycobacterium bovis (323 aa), FASTA scores: opt: 2021, E(): 1.2e-116, (97.5% identity in 323 aa overlap); Q9CB78|ASD|ML2322 from Mycobacterium leprae (351 aa), FASTA scores: opt: 1889,E(): 1.6e-108, (84.45% identity in 347 aa overlap); P41404|DHAS_MYCSM|ASD from Mycobacterium smegmatis (346 aa), FASTA scores: opt: 1801, E(): 3.9e-103, (80.3% identity in 345 aa overlap); etc. Contains PS01103 Aspartate-semialdehyde dehydrogenase signature. BELONGS TO THE ASPARTATE-SEMIALDEHYDE DEHYDROGENASE FAMILY.	X2BNY3,P0A543	No									X2BNY3,P0A543	P0A543									
NC_002945.3	Mycobrowser_v4	CDS	4089566	4090831	.	-	0	Mb3736c	ask		ASPARTOKINASE ASK (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA SUBUNIT (ASK-ALPHA); AND ASPARTOKINASE BETA SUBUNIT (ASK-BETA)]	Mb3736c, ask, len: 421 aa. Equivalent to Rv3709c,len: 421 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 421 aa overlap). ask, aspartokinase (EC 2.7.2.4) (see citation below), equivalent to Q9CB77|ASK|ML2323 from Mycobacterium leprae (421 aa),FASTA scores: opt: 2531, E(): 2e-140, (92.65% identity in 421 aa overlap); and P41403|AK_MYCSM|ASK from Mycobacterium smegmatis (421 aa), FASTA scores: opt: 2423,E(): 4e-134, (88.1% identity in 421 aa overlap); and to several other organisms e.g. Q9RQ25|ASKA from Amycolatopsis mediterranei (421 aa), FASTA scores: opt: 2026, E(): 5.8e-111, (72.2% identity in 421 aa overlap). Contains PS00324 Aspartokinase signature. BELONGS TO THE ASPARTOKINASE FAMILY. ALTERNATIVE PRODUCTS: THE ALPHA AND BETA SUBUNITS OF ASPARTOKINASE ARE PRODUCED BY THE USE OF ALTERNATIVE INITIATION SITES (BY SIMILARITY).	X2BPD7,P0A4Z9	No									X2BPD7,P0A4Z9	P0A4Z9									
NC_002945.3	Mycobrowser_v4	CDS	4091088	4093193	.	+	0	Mb3737	leuA		2-isopropylmalate synthase leua (alpha-isopropylmalate synthase) (alpha-ipm synthetase) (ipms)	Mb3737, leuA, len: 701 aa. Similar to Rv3710, len: 644 aa, from Mycobacterium tuberculosis strain H37Rv,(91.7% identity in 701 aa overlap). leuA,alpha-isopropylmalate synthase (EC 4.1.3.12) (see citations below), equivalent to Q9CB76|LEUA|ML2324 2-ISOPROPYLMALATE SYNTHASE from Mycobacterium leprae (607 aa), FASTA scores: opt: 3291, E(): 3.7e-192, (80.7% identity in 642 aa overlap). Also highly similar to many e.g. P42455|LEU1_CORGL|LEUA from Corynebacterium glutamicum (Brevibacterium flavum) (616 aa), FASTA scores: opt: 2547, E(): 5.3e-147, (63.25% identity in 645 aa overlap); O31046|LEU1_STRCO|LEUA from Streptomyces coelicolor (573 aa), FASTA scores: opt: 2226, E(): 1.5e-127, (57.8% identity in 616 aa overlap); BAB49833|Q98HN3|MLR2792 from Rhizobium loti (Mesorhizobium loti) (588 aa), FASTA scores: opt: 1849, E(): 1.1e-104,(58.0% identity in 536 aa overlap); etc. Equivalent to AAK48181 from Mycobacterium tuberculosis strain CDC1551 (659 aa) but shorter 15 aa. Contains PS00815 and PS00816 Alpha-isopropylmalate and homocitrate synthases signatures 1 and 2. BELONGS TO THE ALPHA-IPM SYNTHETASE / HOMOCITRATE SYNTHASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame insertion of 171 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis (701 aa versus 644 aa).	X2BP46,Q7TVV6	No									X2BP46,Q7TVV6	Q7TVV6									
NC_002945.3	Mycobrowser_v4	CDS	4267771	4272354	.	-	0	Mb3889c	gltB		probable ferredoxin-dependent glutamate synthase [nadph] (large subunit) gltb (l-glutamate synthase) (l-glutamate synthetase) (nadh-glutamate synthase) (glutamate synthase (nadh))(nadph-gogat)	Mb3889c, gltB, len: 1527 aa. Equivalent to Rv3859c,len: 1527 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1527 aa overlap). Probable gltB,ferredoxin-dependent glutamate synthase large subunit (EC 1.4.1.13), equivalent to Q9CDD5|GLTB|ML0061 PUTATIVE FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt: 5790, E(): 0, (63.25% identity in 1534 aa overlap); P39812|GLTB_BACSU|GLTA from Bacillus subtilis (1520 aa), FASTA scores: opt: 3445, E(): 2.8e-196, (52.25% identity in 1531 aa overlap); etc. SIMILAR TO OTHER GLUTAMATE SYNTHASES.	Q7TVH7	No								IPR000583,IPR002489,IPR002932,IPR006982,IPR013785,IPR017932	Q7TVH7	A0A1R3Y5J1									
NC_002945.3	Mycobrowser_v4	CDS	4095687	4096382	.	+	0	Mb3740	cobQ2		POSSIBLE COBYRIC ACID SYNTHASE COBQ2	Mb3740, cobQ2, len: 231 aa. Equivalent to Rv3713,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible cobQ2,cobyric acid synthase (EC undetermined), equivalent to O69521|ML2327|MLCB2407.23c HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium leprae (230 aa), FASTA scores: opt: 1313, E(): 4.7e-73, (86.1% identity in 230 aa overlap). Also partially similar to several cobyric acid synthases and hypothetical proteins e.g. Q9FCA0|2SCG58.13 HYPOTHETICAL 26.2 KDA PROTEIN from Streptomyces coelicolor (242 aa), FASTA scores: opt: 639, E(): 6.2e-32, (46.6% identity in 234 aa overlap); Q9ZGG8|COBQ COBYRIC ACID SYNTHASE from Heliobacillus mobilis (252 aa), FASTA scores: opt: 501, E(): 1.7e-23, (40.75% identity in 206 aa overlap); BAB58053|SAV1891 HYPOTHETICAL 27.4 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (243 aa),FASTA scores: opt: 400, E(): 2.3e-17, (35.95% identity in 217 aa overlap); Q9CGJ1|COBQ COBYRIC ACID SYNTHASE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (261 aa), FASTA scores: opt: 353, E(): 1.8e-14, (35.3% identity in 201 aa overlap); O26880|COBQ_METTH|MTH787 PROBABLE COBYRIC ACID SYNTHASE from Methanobacterium thermoautotrophicum (504 aa), FASTA scores: opt: 201, E(): 5.6e-05, (33.35% identity in 171 aa overlap); etc. Also similar to hypothetical mycobacterial proteins O05811|COBB_MYCTU|Rv2848c|MT2914|MTCY24A1.09 (457 aa) and P71842|Rv0789c|MTCY369.33c (199 aa). SEEMS TO BELONG TO THE COBB/COBQ FAMILY, COBQ SUBFAMILY.	Q7TVV3	No								IPR011698,IPR017929	Q7TVV3	A0A1R3Y524									
NC_002945.3	Mycobrowser_v4	CDS	4172074	4173459	.	+	0	Mb3819	dpre1		decaprenylphosphoryl-beta-d-ribose 2'-oxidase	Mb3819, -, len: 461 aa. Equivalent to Rv3790, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 461 aa overlap). Probable oxidoreductase (EC 1.-.-.-), equivalent to Q9CDA4|ML0109 PUTATIVE FAD-LINKED OXIDOREDUCTASE from Mycobacterium leprae (460 aa), FASTA scores: opt: 2722, E(): 1.4e-161,(86.55% identity in 461 aa overlap). Also highly similar to others e.g. Q9KZA4|SC5G8.10c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (457 aa), FASTA scores: opt: 1336, E(): 1.7e-75, (47.1% identity in 452 aa overlap); Q98KY4|MLL1265 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (449 aa), FASTA scores: opt: 636,E(): 4.9e-32, (36.0% identity in 439 aa overlap); Q9HDX8|SPAPB1A10.12c PUTATIVE D-ARABINONO-1,4-LACTONE OXIDASE from Schizosaccharomyces pombe (Fission yeast) (461 aa), FASTA scores: opt: 297, E(): 5.6e-11, (23.55% identity in 467 aa overlap); etc. C-terminal end has a high similarity to Q9AQD0 PUTATIVE OXIDOREDUCTASE (FRAGMENT) from Mycobacterium smegmatis (149 aa) FASTA scores: opt: 901, E(): 6.5e-49, (86.6% identity in 149 aa overlap).	Q7TVN6	No	lipid metabolism							IPR006094,IPR007173,IPR016166,IPR016169	Q7TVN6	A0A1R3Y598				Rv3790		Rv3790			
NC_002945.3	Mycobrowser_v4	CDS	4200836	4201735	.	-	0	Mb3833c	fbpD		SECRETED MPT51/MPB51 ANTIGEN PROTEIN FBPD (MPT51/MPB51 ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) (85C)	Mb3833c, fbpD, len: 299 aa. Equivalent to Rv3803c,len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 299 aa overlap). fbpD (alternate gene names: mpt51, mpb51, fbpC1), secreted MPB51/MPT51 antigen protein (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below),identical to Q48923|MPT51|MPB51 ANTIGEN PRECURSOR from Mycobacterium bovis (299 aa), FASTA scores: opt: 2093,E(): 1.5e-112, (100.0% identity in 299 aa overlap) (see second citation below); and highly similar to other Mycobacterial antigen precursors e.g. Q05868|MPT5_MYCLE|MPT51|ML0098 MPT51 ANTIGEN PRECURSOR from Mycobacterium leprae (301 aa), FASTA scores: opt: 1624, E(): 9.8e-86, (77.8% identity in 302 aa overlap); O52972|A85C_MYCAV|FBPC ANTIGEN 85-C PRECURSOR (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium avium (352 aa), FASTA scores: opt: 753, E(): 6.6e-36, (41.5% identity in 315 aa overlap); P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR (FIBRONECTIN-BINDING PROTEIN B) from Mycobacterium kansasii (325 aa), FASTA scores: opt: 574,E(): 1.1e-25, (37.55% identity in 309 aa overlap); P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from Mycobacterium bovis (323 aa), FASTA scores: opt: 572, E(): 1.4e-25, (39.85% identity in 291 aa overlap); etc. Also similar to P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 SECRETED ANTIGEN 85-C (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 751, E(): 8.4e-36, (40.65% identity in 310 aa overlap); P17944|A85A_MYCTU|FBPA|MPT44|Rv3804c|MT3911|MTV026.09c SECRETED ANTIGEN 85-A (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) from Mycobacterium tuberculosis (338 aa), FASTA scores: opt: 592, E(): 1e-26,(39.05% identity in 302 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Note that the secreted protein MPB51 is one of the major proteins in the culture filtrate of Mycobacterium bovis BCG.	X2BPV6,P0A4V7	No									X2BPV6,P0A4V7	P0A4V7									
NC_002945.3	Mycobrowser_v4	CDS	4102455	4104191	.	-	0	Mb3748c	dnaZX		DNA POLYMERASE III (SUBUNIT GAMMA/TAU) DNAZ/X	Mb3748c, dnaZX, len: 578 aa. Equivalent to Rv3721c,len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 578 aa overlap). Probable dnaZX, DNA polymerase III gamma (dnaZ) and tau (dnaX) (EC 2.7.7.7),equivalent to O69514|DNAZX|ML2335 DNA POLYMERASE III SUBUNIT GAMMA/TAU from Mycobacterium leprae (611 aa) FASTA scores: opt: 2344, E(): 4.7e-118, (78.75% identity in 602 aa overlap). Also highly similar to many e.g. Q9RKL5|DNAZ from Streptomyces coelicolor (784 aa) FASTA scores: opt: 1755, E(): 1.8e-86, (59.55% identity in 435 aa overlap); Q9KGM4|DNAX|BH0034 from Bacillus halodurans (564 aa),FASTA scores: opt: 946, E(): 2.5e-43, (37.4% identity in 460 aa overlap); P09122|DP3X_BACSU|DNAX|DNAH from Bacillus subtilis (563 aa), FASTA scores: opt: 841, E(): 1e-37,(30.8% identity in 510 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).	X2BPN8,P63976	No									X2BPN8,P63976	P63976									
NC_002945.3	Mycobrowser_v4	CDS	4132465	4132800	.	-	0	Mb3772c	PE34		probable pe family protein pe34 (pe family-related protein)	Mb3772c, PE34, len: 111 aa. Equivalent to Rv3746c,len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Probable member of the Mycobacterium tuberculosis PE family, but without the glycine-rich C-terminal part, similar to N-termini of many e.g. O69737|Rv3872|MTV027.07 (99 aa) FASTA scores: opt: 306, E(): 1e-13, (50.5% identity in 99 aa overlap); O53215|Rv2490c|MTV008.46 (1660 aa) FASTA scores: opt: 125,E(): 0.99, (34.25% identity in 111 aa overlap). Also weakly similar to MTV008_46; MTCI418B_6; MTCY130_1; MTY25D10_11; MTCY1A11_25; MTCY21B4_13; MTCY21B4_27; MTCY493_2; MTCY28_25; etc.	Q7TVS7	No								IPR000084	Q7TVS7	A0A1R3Y541									
NC_002945.3	Mycobrowser_v4	tRNA	4105805	4105890	.	+	0	serV	serV		tRNA-Ser	serV, len: 86 nt. Equivalent to serV, len: 86 nt,from Mycobacterium tuberculosis strain H37RV, (100.0% identity in 86 nt overlap). tRNA-Ser, anticodon gga.		No																			
NC_002945.3	Mycobrowser_v4	CDS	4106927	4107628	.	+	0	Mb3751	cut5		probable cutinase [second part] cut5b	Mb3751, cut5, len: 233 aa. Equivalent to Rv3724A (cut5a) and Rv3724B (cut5b), len: 80 aa and 187 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 67 aa overlap and 100.0% identity in 166 aa overlap). Probable cut5a, truncated cutinase precursor (EC 3.1.1.-),similar to N-terminal end of others e.g. Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 202, E(): 1.5e-06, (56.45% identity in 62 aa overlap); Q9XB09|RVD2-RV1758 PROTEIN (FRAGMENT) from Mycobacterium bovis BCG (143 aa), FASTA scores: opt: 200,E(): 1.5e-06, (61.4% identity in 57 aa overlap); and Q00298|CUTI_BOTCI|CUTA CUTINASE PRECURSOR from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 108, E(): 2.2, (40.4% identity in 52 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 189, E(): 1.2e-05, (58.0% identity in 50 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 172, E(): 0.00015, (59.2% identity in 49 aa overlap); O06793|Rv1758|MTCY28.24|Z95890 HYPOTHETICAL 17.9 KDA PROTEIN (174 aa), FASTA scores: opt: 641, E(): 2.7e-29,(57.2% identity in 166 aa overlap); O06319|Rv3452|MTY13E12.05; and U00015_11 from Mycobaterium leprae. BELONGS TO THE CUTINASE FAMILY. Rest of cutinase ORF continues as Rv3724B|CUT5B, frameshifting could occur near position 4169668. Sequence has been checked but no errors found. Probable cut5b, truncated cutinase (EC 3.1.1.-), similar to C-terminal end of others e.g. Q9XB09|RVD2-RV1758 PROTEIN (FRAGMENT) from Mycobacterium bovis BCG (143 aa) FASTA scores: opt: 335, E(): 3.4e-12,(53.25% identity in 92 aa overlap); Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 251, E(): 2.5e-07, (44.05% identity in 168 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. O06793|Rv1758|MTCY28.24 HYPOTHETICAL 17.9 KDA PROTEIN (174 aa), FASTA scores: opt: 641, E(): 2.5e-29, (57.25% identity in 166 aa overlap); O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN (226 aa), FASTA scores: opt: 385, E(): 7.5e-15, (46.65% identity in 165 aa overlap); O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 307, E(): 1.9e-10, (40.7% identity in 167 aa overlap); Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 261, E(): 6.7e-08, (50.9% identity in 169 aa overlap); etc; and U00015_11 from Mycobacterium lepra. 5'-end of gene is Rv3724A|CUT5A; frameshifting may occur near position 4169668. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product.	Q7TVU5	No	cell wall and cell processes							IPR000675	Q7TVU5	A0A1R3Y4Z4				Rv3724A		Rv3724A			
NC_002945.3	Mycobrowser_v4	CDS	4126745	4127101	.	-	0	Mb3765c	PPE66		ppe family protein ppe66	Mb3765c, PPE66, len: 118 aa. Equivalent to 3' end of Rv3738c, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 105 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa),FASTA scores: opt: 464, E(): 2.2e-17, (47.05% identity in 338 aa overlap). Probably a continuation of the upstream ORF MTV025.87c. At position 97470-72 a stop codon is present which interrupts a possibly longer ORF, observed in related ORFs MTV012_32 or MTCY21B4_4. The sequence has been checked and no errors were detected. A similar situation, but with a frameshift separating the ORFs is found in MTV012_36/MTV012_35. Sequence similarity is also seen with MTCY251_15; MTCY261_19; MLCB2492_30 from Mycobacterium leprae; MTCY10G2_10; MTY21C12_9; MTCI125_26; MTCY164_36; MTCY6A4_1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 1166 bp leads to the loss of the NH2 part of PPE66 and of Rv3739c compared to its homolog in Mycobacterium tuberculosis strain H37Rv.		No																			
NC_002945.3	Mycobrowser_v4	CDS	4119218	4120294	.	+	0	Mb3758	ligC		possible atp-dependent dna ligase ligc (polydeoxyribonucleotide synthase [atp]) (polynucleotide ligase [atp]) (sealase) (dna repair protein) (dna joinase)	Mb3758, ligC, len: 358 aa. Equivalent to Rv3731,len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 358 aa overlap). Possible ligC, DNA ligase ATP-dependent (EC 6.5.1.1), similar to numerous archaebacterial and eukaryotic polynucleotide DNA ligases e.g. Q9XAM3|SC4C6.17c from Streptomyces coelicolor (355 aa), FASTA scores: opt: 1429, E(): 1.7e-82, (60.4% identity in 361 aa overlap); BAB54870|MLL9685 from Rhizobium loti (Mesorhizobium loti) plasmid pMLb (337 aa),FASTA scores: opt: 667, E(): 1.2e-34, (40.35% identity in 347 aa overlap); Q9HH07|DNLI_THEFM|LIG from Thermococcus fumicolans (559 aa), FASTA scores: opt: 335, E(): 1.4e-13,(27.25% identity in 330 aa overlap); O59288|DNLI_PYRHO from Pyrococcus horikoshii (559 aa), FASTA scores: opt: 307, E(): 8e-12, (26.85% identity in 272 aa overlap); etc. Also similar to Rv3062|MTCY22D7_19c|LIGB PROBABLE DNA LIGASE from Mycobacterium tuberculosis (507 aa), FASTA score: (30.3% identity in 356 aa overlap). SEEMS TO BELONG TO THE ATP-DEPENDENT DNA LIGASE FAMILY.	Q7TTR3	No	information pathways							IPR012309,IPR012310,IPR012340	Q7TTR3	A0A1R3Y525				Rv3731		Rv3731			
NC_002945.3	Mycobrowser_v4	CDS	4136715	4137620	.	+	0	Mb3780	tyrA		PREPHENATE DEHYDROGENASE TYRA (PDH) (HYDROXYPHENYLPYRUVATE SYNTHASE)	Mb3780, tyrA, len: 301 aa. Equivalent to Rv3754,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Probable tyrA,prephenate dehydrogenase (EC 1.3.1.12), equivalent, but shorter 27 aa, to Q9CB34|ML2472 POSSIBLE PREPHENATE DEHYDROGENASE from Mycobacterium leprae (327 aa) FASTA scores: opt: 1600, E(): 1.6e-89, (80.0% identity in 300 aa overlap). Also similar to many pephenate dehydrogenases e.g. Q9RND8|TYRA from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (299 aa), FASTA scores: opt: 345, E(): 9.7e-14, (32.85% identity in 271 aa overlap); Q9RVA7|DR1122 from Deinococcus radiodurans (372 aa) FASTA scores: opt: 341, E(): 2e-13, (35.65% identity in 216 aa overlap); P20692|TYRA_BACSU from Bacillus subtilis (372 aa), FASTA scores: opt: 314, E(): 8.6e-12, (27.75% identity in 263 aa overlap); etc. Also similar to Q04983|TYRC_ZYMMO TYRC PROTEIN [INCLUDES: CYCLOHEXADIENYL DEHYDROGENASE AND PREPHENATE DEHYDROGENASE ACTIVITIES] from Zymomonas mobilis (293 aa), FASTA scores: opt: 290,E(): 2e-10, (30.15% identity in 239 aa overlap). Equivalent to AAK48225 from Mycobacterium tuberculosis strain CDC1551 (323 aa) but shorter 22 aa.	Q7TVR9	No	intermediary metabolism and respiration							IPR003099,IPR008927,IPR016040	Q7TVR9	A0A1R3Y570				Rv3754		Rv3754			
NC_002945.3	Mycobrowser_v4	CDS	4121986	4123350	.	-	0	Mb3761c	tgs2		putative triacylglycerol synthase (diacylglycerol acyltransferase) tgs2	Mb3761c, -, len: 454 aa. Equivalent to Rv3734c,len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 454 aa overlap). Hypothetical protein,highly similar to O69707|Y1E0_MYCTU|Rv3740c|MT3848|MTV025.088c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (448 aa), FASTA scores: opt: 1917, E(): 1.3e-111, (61.4% identity in 451 aa overlap); and similar to many other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P71694|YE43_MYCTU|Rv1425|MT1468|MTCY21B4.43|MTCY493.29c (459 aa), FASTA scores: opt: 824, E(): 1.1e-43, (36.5% identity in 460 aa overlap); Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 766, E(): 4.1e-40, (36.4% identity in 453 aa overlap); etc. Also similar to Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 331, E(): 4.3e-13, (32.9% identity in 468 aa overlap); and Q9X7A8|ML1244|MLCB1610.05 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 296, E(): 7e-11, (28.35% identity in 413 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Start site chosen by homology, but may extend further upstream.	X2BPF5,P67211	No	lipid metabolism								X2BPF5,P67211	P67211				Rv3734c		Rv3734c			
NC_002945.3	Mycobrowser_v4	tRNA	4135425	4135511	.	-	0	serX	serX		tRNA-Ser	serX, len: 87 nt. Equivalent to serX, len: 87 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 87 nt overlap). tRNA-Ser, anticodon cga.		No																			
NC_002945.3	Mycobrowser_v4	CDS	4224533	4227802	.	-	0	Mb3853c	mmpL8		conserved integral membrane transport protein mmpl8	Mb3853c, mmpL8, len: 1089 aa. Equivalent to Rv3823c, len: 1089 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1089 aa overlap). Probable mmpL8, conserved integral membrane transport protein (see citation below), member of RND superfamily,equivalent to Q49619|MMLA_MYCLE|MMPL10|TP1|ML1231|B1170_C1_181 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (1008 aa),FASTA scores: opt: 2718, E(): 7.3e-149, (56.25% identity in 1028 aa overlap). Also similar to others e.g. Q9XCF6|TMTPC from Mycobacterium avium (974 aa), FASTA scores: opt: 660, E(): 2.7e-30, (28.2% identity in 1050 aa overlap); Q9XCF5|TMTPB from Mycobacterium avium (963 aa),FASTA scores: opt: 653, E(): 6.7e-30, (27.0% identity in 1014 aa overlap); Q9KH53|TMTPC from Mycobacterium smegmatis (994 aa), FASTA scores: opt: 648, E(): 1.3e-29,(28.45% identity in 1013 aa overlap); etc. Also highly similar to other mmpL proteins from Mycobacterium tuberculosis; O50439|MMLA_MYCTU|MMPL10|RV1183|MT1220|MTV005.19 (1002 aa), FASTA scores: opt: 2777, E(): 2.9e-152, (58.25% identity in 996 aa overlap); Q50585|MMLC_MYCTU|MMPL12|Rv1522c|MT1573|MTCY19G5.06 (1146 aa), FASTA scores: opt: 2433, E(): 2.1e-132, (49.9% identity in 1050 aa overlap); and similar to others e.g. P95235|MML9_MYCTU|MMPL9|Rv2339|MT2402|MTCY98.08 (962 aa),FASTA scores: opt: 651, E(): 8.8e-30, (28.6% identity in 1038 aa overlap); etc. BELONGS TO THE MMPL FAMILY.	X2BPW7,Q7TVL0	No	cell wall and cell processes								X2BPW7,Q7TVL0					Rv3823c		Rv3823c			
NC_002945.3	Mycobrowser_v4	CDS	4129685	4131667	.	-	0	Mb3769c	ctpJ		probable cation transporter p-type atpase ctpj	Mb3769c, ctpJ, len: 660 aa. Equivalent to Rv3743c,len: 660 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 660 aa overlap). Probable ctpJ,cation-transporting P-type ATPase (EC 3.6.1.-),transmembrane protein highly similar to others e.g. Q9ZBF3|SC9B5.27 PUTATIVE CATION-TRANSPORTING ATPASE from Streptomyces coelicolor (638 aa), FASTA scores: opt: 1635,E(): 2.5e-86, (62.25% identity in 63.95 aa overlap); Q59997|CADA|SLR0797 CADMIUM-TRANSPORTING ATPASE from Synechocystis sp. strain PCC 6803 (642 aa), FASTA scores: opt: 1474, E(): 4.3e-77, (42.4% identity in 604 aa overlap); P30336|CADA_BACFI PROBABLE CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa), FASTA scores: opt: 1327, E(): 1.3e-68, (36.6% identity in 626 aa overlap); etc. Also highly similar to O53160|CTPD_MYCTU|Rv1469|MT1515|MTV007.16 PROBABLE CATION-TRANSPORTING P-TYPE ATPASE D from Mycobacterium tuberculosis (657 aa), FASTA scores: opt: 1845, E(): 2.3e-98, (55.85% identity in 650 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site and PS01229 Hypothetical family signature 2. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES).	Q7TVT0	No								IPR001757,IPR008250,IPR018303,IPR023214,IPR023299,IPR027256	Q7TVT0	A0A1R3Y539									
NC_002945.3	Mycobrowser_v4	CDS	4145341	4145820	.	+	0	Mb3789	lpqH		19 KDA LIPOPROTEIN ANTIGEN PRECURSOR LPQH	Mb3789, lpqH, len: 159 aa. Equivalent to Rv3763,len: 159 aa, from Mycobacetrium tuberculosis strain H37Rv,(100.0% identity in 159 aa overlap). lpqH, conserved 19 KDa lipoprotein antigen precursor (see citations below),equivalent to P31502|19KD_MYCIT|MI22 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR (MI22 ANTIGEN) from Mycobacterium intracellulare (162 aa), FASTA scores: opt: 773, E(): 6.2e-35, 75.95(% identity in 162 aa overlap); P46733|19KD_MYCAV 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR from M. avium (161 aa), FASTA scores: opt: 743, E(): 2.5e-33, (72.5% identity in 160 aa overlap); and Q9X7A5|LPQH|ML1966 POSSIBLE LIPOPROTEIN from Mycobacterium leprae FASTA scores: opt: 371, E(): 2.2e-13, (42.6% identity in 162 aa overlap). POSSIBLY ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR. SIMILAR TO OTHER MYCOBACTERIUM 19 KDA ANTIGEN. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.	X2BQ19,P0A5J1	No	cell wall and cell processes								X2BQ19,P0A5J1	P0A5J1				Rv3763		Rv3763			
NC_002945.3	Mycobrowser_v4	CDS	4138188	4138907	.	-	0	Mb3782c	proZ		POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROZ	Mb3782c, proZ, len: 239 aa. Equivalent to Rv3756c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 402, E(): 1.9e-16, (32.0% identity in 203 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 385, E(): 1.8e-15, (30.2% identity in 222 aa overlap); P39775|O34657|OPUBD|PROZ|OPBD_BACSU CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (226 aa) FASTA scores: opt: 350, E(): 2e-13, (31.75% identity in 208 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY.	Q7TVR7	No								IPR000515	Q7TVR7	A0A1R3Y551									
NC_002945.3	Mycobrowser_v4	CDS	4138904	4139593	.	-	0	Mb3783c	proW		POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROW	Mb3783c, proW, len: 229 aa. Equivalent to Rv3757c,len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Possible proW,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58607|Q99RI6|OPUCD|SA2234|SAV2445 OPUCD PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (231 aa) FASTA scores: opt: 364, E(): 7.1e-15, (30.0% identity in 220 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 348, E(): 6.2e-14, (31.05% identity in 206 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 343, E(): 1.2e-13, (30.1% identity in 206 aa overlap); O34742|OPCD_BACSU|OPUCD GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (229 aa) FASTA scores: opt: 337, E(): 2.9e-13, (31.1% identity in 193 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY.	Q7TVR6	No								IPR000515	Q7TVR6	A0A1R3Y549									
NC_002945.3	Mycobrowser_v4	CDS	4139581	4140711	.	-	0	Mb3784c	proV		POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV	Mb3784c, proV, len: 376 aa. Equivalent to Rv3758c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible proV,osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport, e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER (ATP-BINDING) from Staphylococcus aureus (410 aa), FASTA scores: opt: 816, E(): 8.4e-39, (39.5% identity in 362 aa overlap); O34992|OPCA_BACSU|OPUCA GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (380 aa), FASTA scores: opt: 807, E(): 2.5e-38, (40.55% identity in 333 aa overlap); Q45460|OPBA_BACSU|OPUBA|PROV CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (381 aa), FASTA scores: opt: 801, E(): 5.6e-38,(40.65% identity in 337 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporter family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TVR5	No								IPR003439,IPR003593,IPR017871,IPR027417	Q7TVR5	A0A1R3Y530									
NC_002945.3	Mycobrowser_v4	CDS	4140720	4141667	.	-	0	Mb3785c	proX		POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) BINDING LIPOPROTEIN PROX	Mb3785c, proX, len: 315 aa. Equivalent to Rv3759c,len: 315 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 315 aa overlap). Possible proX,osmoprotectant-binding lipoprotein component of osmoprotectant transport system (see citation below),similar to osmoprotection proteins (proX) involved in glycine betaine/L-proline/choline transport, e.g. AAK79442|CAC1474 PROLINE/GLYCINE BETAINE ABC TRANSPORT SYSTEM PERIPLASMIC COMPONENT from Clostridium acetobutylicum (303 aa), FASTA scores: opt: 308, E(): 1.2e-11, (27.4% identity in 314 aa overlap); Q9X4J2|PROXL|SCE19A.33 PROXL PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 302, E(): 3e-11,(27.2% identity in 327 aa overlap); O29280|AF0982 OSMOPROTECTION PROTEIN (PROX) from Archaeoglobus fulgidus (292 aa), FASTA scores: opt: 235, E(): 3.4e-07, (23.15% identity in 285 aa overlap); etc. Also similar to MTV006_16 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and MLU15180_43 HYPOTHETICAL PROTEIN from Mycobacterium leprae. Equivalent to AAK48230 from Mycobacterium tuberculosis strain CDC1551 (343 aa) but shorter 28 aa. Contains probable N-terminal signal sequence.	Q7TVR4	No								IPR007210	Q7TVR4	A0A1R3Y542									
NC_002945.3	Mycobrowser_v4	CDS	4150364	4150723	.	+	0	Mb3794	Mb3794		unknown protein	Mb3794, -, len: 119 aa. Equivalent to Rv3768, len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 119 aa overlap). Hypothetical unknown protein.	Q7TVQ6	No	conserved hypotheticals							IPR009959	Q7TVQ6	A0A1R3Y555				Rv3768		Rv3768			
NC_002945.3	Mycobrowser_v4	CDS	4142156	4143211	.	-	0	Mb3787c	fadE36		POSSIBLE ACYL-COA DEHYDROGENASE FADE36	Mb3787c, fadE36, len: 351 aa. Equivalent to Rv3761c, len: 351 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 351 aa overlap). Possible fadE36, acyl-CoA dehydrogenase (EC 1.3.99.-),similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases,e.g. Q9APX7|FADE36 FADE36 PROTEIN from Pseudomonas aeruginosa (360 aa), FASTA scores: opt: 147, E(): 0.046,(26.15% identity in 214 aa overlap); part of AAB52261.2|U97002 protein similar to acyl-CoA dehydrogenases and epoxide hydrolases from Caenorhabditis elegans (985 aa), FASTA score: (31.2% identity in 324 aa overlap). C-terminal part is highly similar to Q50095|U1740AK|MLU15183_45 hypothetical protein from Mycobacterium leprae cosmid B174 (122 aa), FASTA scores: opt: 341, E(): 7.3e-15, (57.6% identity in 99 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.	Q7TVR2	No	lipid metabolism							IPR002575,IPR011009	Q7TVR2	A0A1R3Y5G9				Rv3761c		Rv3761c			
NC_002945.3	Mycobrowser_v4	CDS	4145876	4147303	.	-	0	Mb3790c	tcry		possible two component sensor kinase tcry	Mb3790c, -, len: 475 aa. Equivalent to Rv3764c,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 475 aa overlap). Possible histidine protein kinase (EC 2.7.3.-), part of a two-component regulatory system, similar to others e.g. Q9ADN6|2SC10A7.25 PUTATIVE TWO COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (524 aa), FASTA scores: opt: 1332, E(): 5.4e-70, (49.9% identity in 477 aa overlap); Q9L3C1|KB|CAC42479 PUTATIVE HISTIDINE KINASE from Amycolatopsis mediterranei (469 aa), FASTA scores: opt: 515, E(): 1.4e-22, (36.1% identity in 313 aa overlap); P72560 HISTIDINE PROTEIN KINASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (438 aa), FASTA scores: opt: 480, E(): 1.4e-20, (40.1% identity in 232 aa overlap); P30847|P76401|BAES_ECOLI|B2078 SENSOR PROTEIN from Escherichia coli strain K12 (467 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. P96368|Rv1032c|MTCY10G2.17 (509 aa), FASTA scores: opt: 1007, E(): 4e-51, (43.5% identity in 416 aa overlap); and P71815|Rv0758|MTCY369.03 (485 aa), FASTA scores: opt: 738,E(): 1.6e-35, (28.6% identity in 438 aa overlap). Equivalent to AAK48235 from Mycobacterium tuberculosis strain CDC1551 (506 aa) but shorter 31 aa.	Q7TVR0	No	regulatory proteins							IPR003594,IPR003660,IPR003661,IPR004358,IPR005467,IPR009082	Q7TVR0	A0A1R3Y574				Rv3764c		Rv3764c			
NC_002945.3	Mycobrowser_v4	CDS	4147374	4148078	.	-	0	Mb3791c	tcrx		probable two component transcriptional regulatory protein tcrx	Mb3791c, -, len: 234 aa. Equivalent to Rv3765c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable response regulator of a two-component regulatory system, highly similar to others e.g. Q9ADN7|2SC10A7.24 PUTATIVE TWO COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (271 aa), FASTA scores: opt: 1111, E(): 4.8e-63, (72.3% identity in 231 aa overlap); Q9F161 RESPONSE REGULATOR from Corynebacterium glutamicum (Brevibacterium flavum) (232 aa), FASTA scores: opt: 692,E(): 1.2e-36, (46.0% identity in 226 aa overlap); Q9KZU5|SCD84.23c PUTATIVE TWO-COMPONENT SYSTEN RESPONSE REGULATOR from Streptomyces coelicolor (248 aa), FASTA scores: opt: 674, E(): 1.7e-35, (44.05% identity in 236 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50806|Rv1033c|MTCY10G2.16 RESPONSE REGULATOR HOMOLOG (257 aa), FASTA scores: opt: 947, E(): 1e-52, (59.5% identity in 232 aa overlap); P71814|Rv0757|MTCY369.02 PHOP-LIKE PROTEIN (247 aa) FASTA scores: opt: 829, E(): 2.8e-45, (54.65% identity in 225 aa overlap); O53894|Rv0981|MTV044.09 (230 aa), FASTA scores: opt: 662, E(): 9e-35, (44.65% identity in 224 aa overlap); and also similar to MTCY31_34; MTCY19H5_20; MTY13628_5; MTCY20G9_17; and to MLCB57_27 from Mycobacterium leprae; and MBY13627_3 from Mycobacterium bovis BCG. Equivalent to AAK48236 from Mycobacterium tuberculosis strain CDC1551 (286 aa) but shorter 52 aa. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION.	Q7TVQ9	No	regulatory proteins							IPR001789,IPR001867,IPR011006,IPR011991	Q7TVQ9	A0A1R3Y557				Rv3765c		Rv3765c			
NC_002945.3	Mycobrowser_v4	CDS	4153428	4154489	.	+	0	Mb3800	hisC2		PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2 (IMIDAZOLE ACETOL-PHOSPHATE TRANSAMINASE) (IMIDAZOLYLACETOLPHOSPHATE AMINOTRANSFERASE)	Mb3800, hisC2, len: 353 aa. Equivalent to Rv3772,len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 353 aa overlap). Probable hisC2,histidinol-phosphate aminotransferase (EC 2.6.1.9), highly similar to Q9ZBY8|SCD78.11 PUTATIVE HISTIDINOL-PHOPHATE AMINOTRANSFERASE from Streptomyces coelicolor (359 aa),FASTA scores: opt: 1165, E(): 7.1e-64, (52.55% identity in 356 aa overlap); and similar to many e.g. Q9EYX2 from Gardnerella vaginalis (317 aa) FASTA scores: opt: 814,E(): 1.7e-42, (45.15% identity in 308 aa overlap); Q9CMI7|HISH_1PM0838|HISH from Pasteurella multocida (365 aa), FASTA scores: opt: 701, E(): 1.5e-35, (35.05% identity in 351 aa overlap); O07131|HIS8_METFL|HISC|HISH from Methylobacillus flagellatum (368 aa), FASTA scores: opt: 645, E(): 4e-32, (34.5% identity in 345 aa overlap); etc. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE.	X2BP56,Q7TVQ0	No									X2BP56,Q7TVQ0	Q7TVQ0									
NC_002945.3	Mycobrowser_v4	CDS	4155144	4155968	.	+	0	Mb3803	echA21		possible enoyl-coa hydratase echa21 (enoyl hydrase) (unsaturated acyl-coa hydratase) (crotonase)	Mb3803, echA21, len: 274 aa. Equivalent to Rv3774,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Possible echA21,enoyl-CoA hydratase (EC 4.2.1.17), equivalent to Q9CD94|ECHA1|ML0120 PUTATIVE ENOYL-COA HYDRATASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1593,E(): 2.2e-92, (88.3% identity in 274 aa overlap). Also similar to others e.g. Q9I2S4|PA1821 from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 761, E(): 2e-40,(42.3% identity in 267 aa overlap); Q9FHR8 from Arabidopsis thaliana (Mouse-ear cress) (278 aa) FASTA scores: opt: 638, E(): 9.9e-33, (39.4% identity in 269 aa overlap); Q9AB78|CC0353 from Caulobacter crescentus (286 aa), FASTA scores: opt: 601, E(): 2.1e-31, (39.25% identity in 266 aa overlap); etc.	Q7TVP7	No								IPR001753,IPR014748	Q7TVP7	A0A1R3Y566									
NC_002945.3	Mycobrowser_v4	CDS	4155980	4157227	.	+	0	Mb3804	lipE		probable lipase lipe	Mb3804, lipE, len: 415 aa. Equivalent to Rv3775,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Probable lipE,hydrolase lipase (EC 3.1.-.-), equivalent to Q9CD95|LIPE|ML0119 PROBABLE HYDROLASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 2418, E(): 6.4e-144,(84.75% identity in 406 aa overlap). Also similar to other esterases e.g. Q9ABH2|CC0255 ESTERASE A from Caulobacter crescentus (374 aa), FASTA scores: opt: 427, E(): 2.4e-19,(28.9% identity in 391 aa overlap); O87861|ESTA ESTERASE A from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 417, E(): 1e-18, (31.0% identity in 361 aa overlap); Q9RK50|SCF12.08 PUTATIVE ESTERASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 385, E(): 1e-16,(31.35% identity in 373 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. P71778|Rv1497|MTCY277.19 HYPOTHETICAL 45.8 KDA PROTEIN (429 aa), FASTA scores: opt: 457, E(): 3.5e-21, (30.4% identity in 395 aa overlap).	Q7TVP6	No	intermediary metabolism and respiration							IPR001466,IPR012338	Q7TVP6	A0A1R3Y568				Rv3775		Rv3775			
NC_002945.3	Mycobrowser_v4	CDS	4212844	4214358	.	+	0	Mb3842	PE_PGRS62		pe-pgrs family protein pe_pgrs62	Mb3842, PE_PGRS62, len: 504 aa. Equivalent to Rv3812, len: 504 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 504 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. P96828|Rv0151c|MTCI5.25c (588 aa), FASTA scores: opt: 389,E(): 6.2e-14, (29.2% identity in 473 aa overlap); MTCY7H7B_27; MTCY493_24; MTCY441_4; MTCY39_36; MTCY1A11_4; MTCY359_33; MTCY130_10; MTCY98_9; etc.	Q7TVM1	No								IPR000084	Q7TVM1	A0A1R3Y5C4									
NC_002945.3	Mycobrowser_v4	CDS	4163824	4164645	.	+	0	Mb3810	rfbE		PROBABLE O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER RFBE	Mb3810, rbfE, len: 273 aa. Equivalent to Rv3781,len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 273 aa overlap). Probable rfbE,polysaccharide-transport ATP-binding protein ABC transporter (see citation below), involved in O-antigen/lipopolysaccharides (LPS) transport, equivalent to Q9CDA0|ML0114 PUTATIVE ABC TRANSPORTER ATP-BINDING COMPONENT from Mycobacterium leprae (272 aa), FASTA scores: opt: 1581, E(): 3e-83, (91.4% identity in 267 aa overlap). Also highly similar to AAK71283 LPS/O-ANTIGEN EXPORT PERMEASE from Coxiella burnetii (258 aa), FASTA scores: opt: 793, E(): 2.5e-38, (45.45% identity in 253 aa overlap); Q9PAF0|XF2568 ABC TRANSPORTER ATP-BINDING PROTEIN from Xylella fastidiosa (246 aa), FASTA scores: opt: 758, E(): 2.4e-36, (47.75% identity in 243 aa overlap); Q56903|RFBE_YEREN O-ANTIGEN EXPORT SYSTEM ATP-BINDING PROTEIN from Yersinia enterocolitica (239 aa),FASTA scores: opt: 697, E(): 7e-33, (48.65% identity in 224 aa overlap); Q50863|RFBB_MYXXA O-ANTIGEN EXPORT SYSTEM ATP-BINDING from Myxococcus xanthus (437 aa), FASTA scores: opt: 605, E(): 2e-27, (42.05% identity in 207 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).	Q7TVP1	No	cell wall and cell processes							IPR003439,IPR003593,IPR027417	Q7TVP1	A0A1R3Y583				Rv3781		Rv3781			
NC_002945.3	Mycobrowser_v4	CDS	4164642	4165556	.	+	0	Mb3811	glft1		udp-galactofuranosyl transferase glft1	Mb3811, -, len: 304 aa. Equivalent to Rv3782, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 304 aa overlap). Possible L-rhamnosyltransferase (EC 2.4.1.-), equivalent to Q9CDA1|RFBE|ML0113 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (283 aa), FASTA scores: opt: 1583,E(): 9.3e-96, (81.6% identity in 277 aa overlap). Also some similarity with AAK68916|WCFN PUTATIVE GLYCOSYLTRANSFERASE from Bacteroides fragilis (291 aa) FASTA scores: opt: 241, E(): 2.1e-08, (30.75% identity in 195 aa overlap); O58161|PH0424 HYPOTHETICAL 40.5 KDA PROTEIN from Pyrococcus horikoshii (348 aa), FASTA scores: opt: 194, E(): 2.8e-05, (23.85% identity in 302 aa overlap); O26448|MTH348 RHAMNOSYL TRANSFERASE from Methanothermobacter thermautotrophicus (313 aa) FASTA scores: opt: 177, E(): 0.00033, (28.2% identity in 333 aa overlap); O07868|CPS19BQ PUTATIVE RHAMNOSYL TRANSFERASE FASTA (300 aa) scores: opt: 156, E(): 0.0074, (25.45% identity in 232 aa overlap); and other putative transferases. Note that C-terminal end shows some similarity with part of Q05161|RFB O-ANTIGEN BIOSYNTHESIS PROTEIN B from Escherichia coli strain 0101. Note that previously known as rfbE.	Q7TVP0	No	cell wall and cell processes								Q7TVP0	A0A1R3Y572				Rv3782		Rv3782			
NC_002945.3	Mycobrowser_v4	CDS	4165553	4166395	.	+	0	Mb3812	rfbD		PROBABLE O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER RFBD	Mb3812, rfbD, len: 280 aa. Equivalent to Rv3783,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Possible rfbD,polysaccharide-transport integral membrane protein ABC transporter (see citation below), involved in O-antigen/lipopolysaccharides (LPS) transport, equivalent to Q9CDA2|ML0112 PUTATIVE ABC TRANSPORTER COMPONENT from Mycobacterium leprae (276 aa), FASTA scores: opt: 1646,E(): 4e-102, (84.3% identity in 280 aa overlap). Also highly similar to Q9PAF1|XF2567 ABC TRANSPORTER PERMEASE PROTEIN from Xylella fastidiosa (267 aa), FASTA scores: opt: 723, E(): 7.6e-41, (41.3% identity in 259 aa overlap); and similar to others e.g. Q56902|RFBD_YEREN O-ANTIGEN EXPORT SYSTEM PERMEASE PROTEIN from Yersinia enterocolitica (259 aa), FASTA scores: opt: 566, E(): 2e-30, (28.05% identity in 264 aa overlap); Q06955|RFBH RFBH PROTEIN (involved in the export of lipopolysaccharide) (alias Q9KVA3|VC0246) LIPOPOLYSACCHARIDE/O-ANTIGEN TRANSPORT PROTEIN from Vibrio cholerae (257 aa), FASTA scores: opt: 358, E(): 1.3e-16,(24.4% identity in 258 aa overlap); Q9HTB8|WZM|PA5451 MEMBRANE SUBUNIT OF A-BAND LPS EFFLUX TRANSPORTER from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 263,E(): 2.7e-10, (25.45% identity in 263 aa overlap); etc. BELONGS TO THE ABC-2 SUBFAMILY OF INTEGRAL MEMBRANE PROTEINS.	Q7TVN9	No	cell wall and cell processes							IPR013525	Q7TVN9	A0A1R3Y577				Rv3783		Rv3783			
NC_002945.3	Mycobrowser_v4	CDS	4166551	4167531	.	+	0	Mb3813	rfbB		possible dtdp-glucose 4,6-dehydratase	Mb3813, rfbB, len: 326 aa. Equivalent to Rv3784,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 326 aa overlap). Possible rfbB,dTDP-glucose 4,6-dehydratase (EC 4.2.1.46), similar to others e.g. Q9YCT1|APE1180 LONG HYPOTHETICAL DTDP-GLUCOSE 4,6-DEHYDRATASE from Aeropyrum pernix (330 aa) FASTA scores: opt: 598, E(): 3.7e-30, (34.9% identity in 315 aa overlap); O27817|MTH1789 DTDP-GLUCOSE 4,6-DEHYDRATASE from Methanothermobacter thermautotrophicus (336 aa) FASTA scores: opt: 587, E(): 1.8e-29, (34.9% identity in 315 aa overlap); Q9X5W0|GRSE TDP-GLUCOSE-4,6-DEHYDRATASE HOMOLOG from Streptomyces griseus (324 aa), FASTA scores: opt: 583, E(): 3.2e-29, (35.7% identity in 325 aa overlap); Q9K7J7|SPSJ|BH3364 SPORE COAT POLYSACCHARIDE SYNTHESIS (DTDP GLUCOSE 4, 6-DEHYDRATASE) from Bacillus halodurans (321 aa), FASTA scores: opt: 562, E(): 6.5e-28, (33.0% identity in 318 aa overlap); Q9UZH2|RFBB|PAB0785 DTDP-GLUCOSE 4,6-DEHYDRATASE from Pyrococcus abyssi (333 aa), FASTA scores: opt: 552, E(): 2.8e-27, (33.95% identity in 318 aa overlap); P27830|RFFG_ECOLI|B3788 DTDP-GLUCOSE 4,6-DEHYDRATASE from Escherichia coli strain K12 (355 aa), FASTA scores: opt: 401, E(): 7.5e-28, (31.3% identity in 348 aa overlap); etc. But also similar to several UDP-glucose 4-epimerases (EC 5.1.3.2) and other proteins e.g. O59375|PH1742 LONG HYPOTHETICAL UDP-GLUCOSE 4-EPIMERASE from Pyrococcus horikoshii (306 aa) FASTA scores: opt: 600, E(): 2.6e-30, (34.5% identity in 313 aa overlap); Q9ZGC7|LANH14 NDP-HEXOSE 4,6-DEHYDRATASE HOMOLOGfrom Streptomyces cyanogenus (326 aa), FASTA scores: opt: 593, E(): 7.6e-30, (36.45% identity in 321 aa overlap); Q57664|GALE_METJA|MJ0211 PUTATIVE UDP-GLUCOSE 4-EPIMERASE from Methanococcus jannaschii (305 aa) FASTA scores: opt: 575, E(): 9.6e-29, (32.6% identity in 313 aa overlap); etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY, DTDP-GLUCOSE DEHYDRATASE SUBFAMILY. Note that previously known as epiB.	Q7TVN8	No	intermediary metabolism and respiration							IPR001509,IPR016040	Q7TVN8	A0A1R3Y576				Rv3784		Rv3784			
NC_002945.3	Mycobrowser_v4	CDS	4173460	4174224	.	+	0	Mb3820	dpre2		decaprenylphosphoryl-d-2-keto erythro pentose reductase	Mb3820, -, len: 254 aa. Equivalent to Rv3791, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 254 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to Q9CDA5|ML0108 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (254 aa), FASTA scores: opt: 1458, E(): 1.6e-83,(89.0% identity in 254 aa overlap); and O05764 PUTATIVE PROTEIN BELONGING TO THE SHORT-CHAIN ALCOHOL DEHYDROGENASE from Mycobacterium smegmatis (254 aa), FASTA scores: opt: 1412, E(): 1.2e-80, (85.05% identity in 254 aa overlap). Also highly similar to Q9KZA5|SC5G8.09c PUTATIVE SHORT-CHAIN DEHYDROGENASE from Streptomyces coelicolor (256 aa), FASTA scores: opt: 733, E(): 1.8e-38, (45.3% identity in 254 aa overlap); and P43168|YMP3_STRCO HYPOTHETICAL OXIDOREDUCTASE from Streptomyces coelicolor (251 aa), FASTA scores: opt: 623, E(): 1.2e-31, (42.15% identity in 254 aa overlap); and similar to various oxidoreductases (principally acetoacetyl-CoA reductases) e.g. P14697|PHBB_ALCEU ACETOACETYL-COA REDUCTASE (EC 1.1.1.36) (246 aa) from Alcaligenes eutrophus (Ralstonia eutropha) (246 aa) FASTA scores: opt: 264, E(): 2.3e-09,(29.9% identity in 204 aa overlap); P45375|PHBB_CHRVI ACETOACETYL-COA REDUCTASE from Chromatium vinosum (246 aa), FASTA scores: opt: 261, E(): 3.5e-09, (27.45% identity in 226 aa overlap); Q9RT30|DR1938 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Deinococcus radiodurans (283 aa), FASTA scores: opt: 251,E(): 1.7e-08, (27.55% identity in 236 aa overlap); etc. Also similar to Q10681|YK73_MYCTU|Rv2073c|MT2133|MTCY49.12 PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mycobacterium tuberculosis (249 aa), FASTA scores: opt: 589, E(): 1.5e-29, (41.25% identity in 252 aa overlap). Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.	X2BP85,P66784	No	lipid metabolism								X2BP85,P66784	P66784				Rv3791		Rv3791			
NC_002945.3	Mycobrowser_v4	CDS	4187380	4189161	.	+	0	Mb3826	fadE35		PROBABLE ACYL-COA DEHYDROGENASE FADE35	Mb3826, fadE35, len: 593 aa. Equivalent to Rv3797,len: 593 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 593 aa overlap). Probable fadE35,acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9HY33|PA3593 from Pseudomonas aeruginosa (575 aa) FASTA scores: opt: 838, E(): 2.1e-46, (35.3% identity in 569 aa overlap); Q9ANZ8|AIDB from Burkholderia pseudomallei (Pseudomonas pseudomallei) (554 aa), FASTA scores: opt: 633, E(): 3.4e-33, (33.1% identity in 480 aa overlap); Q9HX44|PA3972 from Pseudomonas aeruginosa (549 aa) FASTA scores: opt: 560, E(): 1.7e-28, (29.9% identity in 569 aa overlap); P33224|AIDB_ECOLI|B4187 from Escherichia coli strain K12 (541 aa), FASTA scores: opt: 455, E(): 1e-21,(31.15% identity in 514 aa overlap); etc. Also similar to O86368|FADE8|Rv0672|MTCI376.02c ACYL-COA DEHYDROGENASE from Mycobacterium tuberculosis (542 aa), FASTA scores: opt: 479, E(): 2.9e-23, (32.2% identity in 460 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.	Q7TVN1	No								IPR006091,IPR009075,IPR009100	Q7TVN1	A0A1R3Y6S9									
NC_002945.3	Mycobrowser_v4	CDS	4174227	4176158	.	+	0	Mb3821	afta		arabinofuranosyltransferase afta	Mb3821, -, len: 643 aa. Equivalent to Rv3792, len: 643 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 643 aa overlap). Probable conserved transmembrane protein, equivalent, but longer 21 aa, to Q9CDA6|ML0107 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (632 aa), FASTA scores: opt: 1981, E(): 2.1e-110,(77.5% identity in 631 aa overlap). C-terminal end highly similar to C-terminus of O05765 PUTATIVE PRODUCT ORF 3 from Mycobacterium smegmatis (603 aa), FASTA scores: opt: 1261, E(): 1.4e-67, (70.7% identity in 266 aa overlap).	X2BPK7,Q7TVN5	No	cell wall and cell processes								X2BPK7,Q7TVN5	Q7TVN5				Rv3792		Rv3792			
NC_002945.3	Mycobrowser_v4	CDS	4176158	4179442	.	+	0	Mb3822	embC		INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBC (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE)	Mb3822, embC, len: 1094 aa. Equivalent to Rv3793,len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1094 aa overlap). embC, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below),equivalent to Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa) FASTA scores: opt: 6078,E(): 0, (82.95% identity in 1072 aa overlap); Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 5523, E(): 0, (75.35% identity in 1072 aa overlap). Also similar to Q9CDA9|EMBB| ML0104 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1083 aa), FASTA scores: opt: 2789, E(): 1.9e-156, (44.0% identity in 1095 aa overlap); O30406|EMBB PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1082 aa), FASTA scores: opt: 2746, E(): 6.4e-154, (44.6% identity in 1096 aa overlap); etc. Also similar to to P72030|EMBB|Rv3795|MTCY13D12.29 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1098 aa), FASTA scores: opt: 2276, E(): 3.1e-126, (44.45% identity in 1118 aa overlap); and P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1974, E(): 1.9e-108, (41.0% identity in 1110 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature; and PS00017 ATP/GTP-binding site motif A (P-loop).	X2BPF1,Q7TVN4	No									X2BPF1,Q7TVN4	Q7TVN4									
NC_002945.3	Mycobrowser_v4	CDS	4179528	4182812	.	+	0	Mb3823	embA		INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBA (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE)	Mb3823, embA, len: 1094 aa. Equivalent to Rv3794,len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1094 aa overlap). embA, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below),equivalent to P71485|EMBA ARABINOSYL TRANSFERASE from Mycobacterium avium (1108 aa), FASTA scores: opt: 5024,E(): 0, (81.9% identity in 1109 aa overlap); Q9CDA8|EMBA|ML0105 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1111 aa), FASTA scores: opt: 4782,E(): 0, (78.6% identity in 1111 aa overlap); Q50394|EMBA PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1092 aa), FASTA scores: opt: 4100, E(): 0,(67.4% identity in 1092 aa overlap). Also similar to Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa), FASTA scores: opt: 1933,E(): 1.5e-100, (40.6% identity in 1108 aa overlap); Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 1870, E(): 5.1e-97, (41.4% identity in 1113 aa overlap); etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1974, E(): 7.7e-103, (40.9% identity in 1110 aa overlap); and P72030|EMBB|Rv3795|MTCY13D12.29 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1098 aa), FASTA scores: opt: 1288, E(): 2.1e-64, (42.5% identity in 1114 aa overlap). Supposed regulated by embR|Rv1267c.	X2BPU8,P0A561	No									X2BPU8,P0A561	P0A561									
NC_002945.3	Mycobrowser_v4	CDS	4210012	4210866	.	+	0	Mb3840	pirG		EXPORTED REPETITIVE PROTEIN PRECURSOR PIRG (CELL SURFACE PROTEIN) (EXP53)	Mb3840, pirG, len: 284 aa. Equivalent to Rv3810,len: 284 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 284 aa overlap). pirG (alternate gene names: P36 or erp for Exported Repeated Protein), cell surface protein precursor (see citations below),equivalent to P19361|28KD_MYCLE|ML0091 28 KDA ANTIGEN PRECURSOR from Mycobacterium leprae (236 aa), FASTA scores: opt: 555, E(): 9.8e-18, (52.65% identity in 281 aa overlap).	X2BPB4,P0A5P5	No	cell wall and cell processes								X2BPB4,P0A5P5					Rv3810		Rv3810			
NC_002945.3	Mycobrowser_v4	CDS	4190653	4192221	.	-	0	Mb3829c	accD4		PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 4 ACCD4 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)	Mb3829c, accD4, len: 522 aa. Equivalent to Rv3799c,len: 522 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 522 aa overlap). Probable accD4,propyonyl-CoA carboxylase beta chain 4 (EC 6.4.1.3),equivalent to Q9CDB0|ACCD4|ML0102 PUTATIVE ACYL COA CARBOXYLASE from Mycobacterium leprae (517 aa) FASTA scores: opt: 3154, E(): 8e-187, (91.2% identity in 511 aa overlap) . Also similar to many e.g. Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA scores: opt: 1714,E(): 4.4e-98, (50.0% identity in 510 aa overlap); P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa), FASTA scores: opt: 1549, E(): 6.6e-88, (50.65% identity in 519 aa overlap); Q9WZH5|TM0716 from Thermotoga maritima (515 aa) FASTA scores: opt: 1529, E(): 1.1e-86, (46.7% identity in 512 aa overlap); etc. Also similar to P53002|PCCB_MYCLE|ACCD5|PCCB|ML0731|B1308_C1_125 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 from Mycobacterium leprae (549 aa), FASTA scores: opt: 1493, E(): 1.9e-84,(49.8% identity in 514 aa overlap); and P96885|PCC5_MYCTU|ACCD5|PCCB|Rv3280|MT3379.1|MTCY71.20 PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 from Mycobacterium tuberculosis (548 aa), FASTA scores: opt: 1471, E(): 4.2e-83, (49.15% identity in 515 aa overlap). BELONGS TO THE ACCD/PCCB FAMILY.	Q7TVN0	No								IPR000022,IPR011762,IPR011763	Q7TVN0										
NC_002945.3	Mycobrowser_v4	CDS	4192218	4197419	.	-	0	Mb3830c	pks13		POLYKETIDE SYNTHASE PKS13	Mb3830c, pks13, len: 1733 aa. Equivalent to Rv3800c, len: 1733 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1733 aa overlap). Probable pks13, polyketide synthase (EC undetermined),equivalent to Q9CDB1|PKS13|ML0101 POLYKETIDE SYNTHASE from Mycobacterium leprae (1784 aa), FASTA scores: opt: 7454,E(): 0, (83.6% identity in 1748 aa overlap); and similar to Q9Z5K6|ML2357|MLCB12.02c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1871 aa), FASTA scores: opt: 1682, E(): 1.2e-85, (38.3% identity in 1096 aa overlap). Also similar in part to many e.g. Q9ADL6|SORA SORAPHEN POLYKETIDE SYNTHASE A from Polyangium cellulosum (6315 aa) FASTA scores: opt: 1422, E(): 1e-70, (31.45% identity in 1616 aa overlap); AAK73501|AMPHI AMPHI PROTEIN (involved in amphotericin biosynthesis) from Streptomyces nodosus (9510 aa), FASTA scores: opt: 1441, E(): 1.2e-71, (30.45% identity in 1662 aa overlap); Q9RFL0|MTAB MTAB PROTEIN (involved in myxothiazol biosynthesis) from Stigmatella aurantiaca (4003 aa), FASTA scores: opt: 1429, E(): 2.8e-71, (33.8% identity in 1089 aa overlap); Q9L4X2|NYSJ from Streptomyces noursei (5435 aa), FASTA scores: opt: 1407, E(): 6.1e-70, (30.5% identity in 1764 aa overlap); CAC37876|SC1G7.01c from Streptomyces coelicolor (3489 aa) FASTA scores: opt: 1382, E(): 1e-68, (31.05% identity in 1489 aa overlap); etc. Also highly similar to Q10977|PPSA_MYCTU|Rv2931|MT3000|MTCY338.20 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE from Mycobacterium tuberculosis (1876 aa), FASTA scores: opt: 1728, E(): 3.4e-88, (36.95% identity in 1269 aa overlap); and P96203|PPSD|Rv2934|MTCY19H9.02. Contains PS00606 Beta-ketoacyl synthases active site.	Q7TVM9	No	lipid metabolism							IPR001031,IPR001227,IPR009081,IPR014030,IPR014031,IPR014043,IPR016035,IPR016036,IPR016038,IPR016039,IPR018201,IPR020801,IPR020806	Q7TVM9					Rv3800c		Rv3800c			
NC_002945.3	Mycobrowser_v4	CDS	4205198	4206106	.	-	0	Mb3836c	ubia		decaprenylphosphoryl-5-phosphoribose (dppr) synthase (decaprenyl-phosphate 5-phosphoribosyltransferase)	Mb3836c, -, len: 302 aa. Equivalent to Rv3806c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 302 aa overlap). Possible conserved integral membrane protein, equivalent to Q9CDB5|ML0095 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (302 aa), FASTA scores: opt: 1677, E(): 3.9e-103,(83.75% identity in 302 aa overlap). Also highly similar to others e.g. Q9KZA2|SC5G8.12 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 937, E(): 2e-54, (51.4% identity in 292 aa overlap); AAK79783|CAC1818 CONSERVED MEMBRANE PROTEIN,POSSIBLE 4-HYDROXYBENZOATE from Clostridium acetobutylicum (290 aa), FASTA scores: opt: 467, E(): 1.5e-23, (26.9% identity in 290 aa overlap); Q98KY3|MLL1266 NODULATION PROTEIN NOEC (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Rhizobium loti (Mesorhizobium loti) (297 aa), FASTA scores: opt: 331, E(): 1.4e-14, (27.4% identity in 299 aa overlap); etc. And highly similar to C-terminal part of Q981F8|MLR9393 NODULATION PROTEIN NOEC (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Rhizobium loti (Mesorhizobium loti) plasmid pMLa (541 aa), FASTA scores: opt: 388, E(): 4e-18,(30.9% identity in 301 aa overlap); and P55585|Y4NM_RHISN INTEGRAL MEMBRANE PROTEIN (POSSIBLE PERMEASE/TRANSPORTER) from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (516 aa), FASTA scores: opt: 380, E(): 1.3e-17, (31.85% identity in 295 aa overlap). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature.	Q7TVM6	No	cell wall and cell processes							IPR000537	Q7TVM6					Rv3806c		Rv3806c			
NC_002945.3	Mycobrowser_v4	CDS	4197426	4199339	.	-	0	Mb3831c	fadD32		fatty-acid-amp ligase fadd32 (fatty-acid-amp synthetase) (fatty-acid-amp synthase). also shown to have acyl-acp ligase activity.	Mb3831c, fadD32, len: 637 aa. Equivalent to Rv3801c, len: 637 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 637 aa overlap). Probable fadD32, fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to Q9CDB2|FADD32|ML0100 PUTATIVE ACYL-COA SYNTHETASE from Mycobacterium leprae (635 aa), FASTA scores: opt: 3892,E(): 0, (93.05% identity in 632 aa overlap); and highly similar to others from Mycobacterium leprae. Also similar to others from Mycobacterium tuberculosis e.g. P95288|FADD31|Rv1925|MTCY09F9.39c (620 aa), FASTA scores: opt: 1567, E(): 1.7e-88, (47.05% identity in 612 aa overlap); MTCY338_18, MTCY349_40, MTV005_21, MTCY24G1_8,MTCY19G5_7, MTCY4D9_17; and MBU75685_1 ACYL-COA LIGASE from Mycobacterium bovis.	X2BPL9,Q7TTR2	No	lipid metabolism								X2BPL9,Q7TTR2					Rv3801c		Rv3801c			
NC_002945.3	Mycobrowser_v4	CDS	4201915	4202931	.	-	0	Mb3834c	fbpA		SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) (ANTIGEN 85 COMPLEX A)	Mb3834c, fbpA, len: 338 aa. Equivalent to Rv3804c,len: 338 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 338 aa overlap). fbpA (alternate gene names: mpt44, 85A), precursor of the 85-A antigen (fibronectin-binding protein A) (mycolyl transferase 85A) (EC 2.3.1.-) (see citations below), identical to P17944|P17996|FBPA|MPT44 ANTIGEN 85-A PRECURSOR from Mycobacterium bovis (338 aa), FASTA scores: opt: 2341,E(): 1.2e-132, (100.0% identity in 338 aa overlap); and highly similar to other Mycobacterial antigen precursors e.g. O52956|A85A_MYCAV|FBPA ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium avium (347 aa), FASTA scores: opt: 1987, E(): 1.7e-111, (82.55% identity in 338 aa overlap); Q05861|A85A_MYCLE|FBPA|ML0097 ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium leprae (330 aa), FASTA scores: opt: 1936, E(): 1.9e-108, (83.0% identity in 329 aa overlap); O06052|A85A_MYCGO|FBPA ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium gordonae (339 aa), FASTA scores: opt: 1932,E(): 3.3e-108, (80.45% identity in 338 aa overlap); etc. Also highly similar to P31952|A85B_MYCTU|FBPB|Rv1886c|MT1934|MTCY180.32 SECRETED ANTIGEN 85-B from Mycobacterium tuberculosis (325 aa),FASTA scores: opt: 1830, E(): 3.9e-102, (78.85% identity in 317 aa overlap); P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 SECRETED ANTIGEN 85-C from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 1597, E(): 3.4e-88, (67.25% identity in 336 aa overlap).	X2BQ28,P0C2T1	No									X2BQ28,P0C2T1										
NC_002945.3	Mycobrowser_v4	CDS	4203226	4205109	.	-	0	Mb3835c	aftb		possible arabinofuranosyltransferase aftb	Mb3835c, -, len: 627 aa. Equivalent to Rv3805c,len: 627 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 627 aa overlap). Probable conserved transmembrane protein, equivalent, but shorter 19 aa, to Q9CDB4|ML0096 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (649 aa), FASTA scores: opt: 3511, E(): 1.1e-204,(80.9% identity in 629 aa overlap). Equivalent to AAK48278 from Mycobacterium tuberculosis strain CDC1551 (641 aa) but shorter 14 aa.	Q7TVM7	No	cell wall and cell processes								Q7TVM7					Rv3805c		Rv3805c			
NC_002945.3	Mycobrowser_v4	CDS	4206639	4208552	.	-	0	Mb3838c	glft2		bifunctional udp-galactofuranosyl transferase glft2	Mb3838c, -, len: 637 aa. Equivalent to Rv3808c,len: 637 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 637 aa overlap). Galactofuranosyl transferase (EC 2.-.-.-) (see citations below), equivalent to Q9CDB7|ML0093 HYPOTHETICAL PROTEIN from Mycobacterium leprae (643 aa) FASTA scores: opt: 3751, E(): 0, (85.4% identity in 643 aa overlap). Contains a beta-glycosyltransferase domain A.	Q7TVM4	No	cell wall and cell processes								Q7TVM4					Rv3808c		Rv3808c			
NC_002945.3	Mycobrowser_v4	CDS	4208549	4209748	.	-	0	Mb3839c	glf		UDP-GALACTOPYRANOSE MUTASE GLF (UDP-GALP MUTASE) (NAD+-FLAVIN ADENINE DINUCLEOTIDE-REQUIRING ENZYME)	Mb3839c, glf, len: 399 aa. Equivalent to Rv3809c,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 399 aa overlap). glf (alternate gene name: ceoA), UDP-galactopyranose mutase (EC 5.4.99.9) (see citations below), identical to previously sequenced gene,and equivalent to Q9CDB8|GLF|ML0092 PUTATIVE UDP-GALACTOPYRANOSE MUTASE from Mycobacterium leprae (413 aa), FASTA scores: opt: 2347, E(): 1.3e-140, (86.6% identity in 396 aa overlap). Also highly similar to others e.g. AAK61905|EPSJ UDP-GALACTOPYRANOSE MUTASE (PROTEIN INVOLVED IN EXOPOLYSACCHARIDES BIOSYNTHESIS) from Streptococcus thermophilus (365 aa), FASTA scores: opt: 972, E(): 5.9e-54, (45.85% identity in 375 aa overlap); P37747|GLF_ECOLI|B2036 UDP-GALACTOPYRANOSE MUTASE from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 958, E(): 4.5e-53, (43.55% identity in 379 aa overlap); O86897|CAP33FN from Streptococcus pneumoniae (369 aa) FASTA scores: opt: 954, E(): 8.1e-53, (44.8% identity in 375 aa overlap); etc. COFACTOR: FAD (BY SIMILARITY). N-TERMINAL SHOWS SIMILARITY TO FAD OR NAD CONTAINING PROTEINS.	Q7TVM3	No								IPR004379,IPR015899,IPR016040	Q7TVM3										
NC_002945.3	Mycobrowser_v4	CDS	4220692	4222098	.	-	0	Mb3850c	papA2		POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA2	Mb3850c, papA2, len: 468 aa. Equivalent to Rv3820c,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 468 aa overlap). Possible papA2,conserved polyketide synthase (PKS) associated protein,highly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-ASSOCIATED PROTEIN A3 from Mycobacterium leprae (471 aa), FASTA scores: opt: 1660, E(): 2.7e-102, (53.95% identity in 456 aa overlap). Also similar to Q9F2R3|SCD65.19c HYPOTHETICAL 52.8 KDA PROTEIN from Streptomyces coelicolor (473 aa), FASTA scores: opt: 575,E(): 1.8e-30, (27.8% identity in 464 aa overlap); and weakly similar to part of other proteins. Also high similarity with other PKS-ASSOCIATED PROTEINS from Mycobacterium tuberculosis; O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt: 1694, E(): 1.5e-104, (53.8% identity in 461 aa overlap); and O07799|PAPA1|Rv3824c|MTCY409.06 (511 aa), FASTA scores: opt: 1664, E(): 1.6e-102, (53.9% identity in 462 aa overlap); and similar to C-terminal end of O53902|PAPA4|Rv1528c|MTV045.02 (165 aa), FASTA scores: opt: 186, E(): 4.1e-05, (37.9% identity in 66 aa overlap).	X2BPC4,Q7TVL3	No									X2BPC4,Q7TVL3										
NC_002945.3	Mycobrowser_v4	CDS	4227912	4229447	.	-	0	Mb3854c	papA1		conserved polyketide synthase associated protein papa1	Mb3854c, papA1, len: 511 aa. Equivalent to Rv3824c,len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Possible papA1,conserved polyketide synthase (PKS) associated protein,highly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-ASSOCIATED PROTEIN A3 from Mycobacterium leprae (471 aa), FASTA scores: opt: 1879, E(): 7.1e-111, (55.5% identity in 465 aa overlap). Also similar to Q9F2R3|SCD65.19c HYPOTHETICAL 52.8 KDA PROTEIN from Streptomyces coelicolor (473 aa), FASTA scores: opt: 476,E(): 1.7e-22, (26.7% identity in 464 aa overlap); and similar in part to Q09164|SIMA|CYSYN CYCLOSPORIN SYNTHETASE from Tolypocladium inflatum (15281 aa) FASTA scores: opt: 238, E(): 2.8e-06, (22.35% identity in 371 aa overlap). Also highly similar to other PKS-ASSOCIATED PROTEINS from Mycobacterium tuberculosis; O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt: 1862, E(): 8.4e-110, (55.95% identity in 470 aa overlap); and upstream ORF O07803|PAPA2|Rv3820c|MTCY409.10 (468 aa) FASTA scores: opt: 1664, E(): 2.5e-97, (53.9% identity in 462 aa overlap). Contains PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.	X2BQ32,Q7TVK9	No									X2BQ32,Q7TVK9										
NC_002945.3	Mycobrowser_v4	CDS	4229498	4235878	.	-	0	Mb3855c	pks2		POLYKETIDE SYNTHASE PKS2	Mb3855c, pks2, len: 2126 aa. Equivalent to Rv3825c,len: 2126 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 2126 aa overlap). Probable pks2, polyketide synthase (EC undetermined), equivalent to Q9CD78|MAS|ML0139 PUTATIVE MYCOCEROSIC SYNTHASE from Mycobacterium leprae (2116 aa), FASTA scores: opt: 6828,E(): 0, (63.3% identity in 2128 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE from Mycobacterium leprae (2118 aa) FASTA scores: opt: 5220, E(): 0, (62.4% identity in 2130 aa overlap); or similar in part to others from Mycobacterium leprae e.g. Q9CB70|ML2354 POLYKETIDE SYNTHASE (1822 aa) FASTA scores: opt: 2787, E(): 2.1e-145, (34.7% identity in 2135 aa overlap). Also highly similar to Q02251|MCAS_MYCBO|MAS MYCOCEROSIC ACID SYNTHASE from Mycobacterium bovis (2110 aa), FASTA scores: opt: 3495,E(): 2.6e-184, (61.65% identity in 2130 aa overlap). Also highly similar to other polyketide synthases from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 (2108 aa) FASTA scores: opt: 9576, E(): 0, (69.8% identity in 2124 aa overlap); P96291|MAS|Rv2940c|MTCY24G1.09|MTCY19H9.08c (2111 aa), FASTA scores: opt: 3518, E(): 1.4e-185, (64.05% identity in 2126 aa overlap); O50437|PKS4|Rv1181|MTV005.17 (1582 aa), FASTA scores: opt: 3461, E(): 1.6e-182, (64.55% identity in 1609 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site and PS00012 Phosphopantetheine attachment site.	X2BPD2,Q7TVK8	No									X2BPD2,Q7TVK8										
NC_002945.3	Mycobrowser_v4	CDS	4236085	4237839	.	+	0	Mb3856	fadD23		probable fatty-acid-amp ligase fadd23 (fatty-acid-amp synthetase) (fatty-acid-amp synthase)	Mb3856, fadD23, len: 584 aa. Equivalent to Rv3826,len: 584 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 584 aa overlap). Probable fadD23,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to P71495 ACYL-COA SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores: opt: 2571, E(): 4.4e-146, (66.15% identity in 576 aa overlap); Q9CD79|FADD28|ML0138 ACYL-COA SYNTHETASE from Mycobacterium leprae (579 aa) FASTA scores: opt: 2520, E(): 4.9e-143, (65.2% identity in 575 aa overlap); P54200|FD21_MYCLE PUTATIVE FATTY-ACID--COA LIGASE (ACYL-COA SYNTHETASE) from Mycobacterium leprae (579 aa), FASTA scores: opt: 2330, E(): 1.1e-131, (60.2% identity in 578 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P96290|FADD28|Rv2941|MTCY24G1.08c (580 aa), FASTA scores: opt: 2587, E(): 4.9e-147, (66.5% identity in 576 aa overlap); O53903|FADD24|Rv1529|MTV045.03 (584 aa), FASTA scores: opt: 2457, E(): 2.9e-139, (63.35% identity in 584 aa overlap); Q50586|FADD25|Rv1521|MT1572|MTCY19G5.07 (583 aa) FASTA scores: opt: 2389, E(): 3.3e-135, (61.45% identity in 581 aa overlap); etc.	X2BPQ7,Q7TVK7	No									X2BPQ7,Q7TVK7										
NC_002945.3	Mycobrowser_v4	CDS	4243928	4245187	.	-	0	Mb3864c	serS		SERYL-TRNA SYNTHETASE SERS (SERINE--TRNA LIGASE) (SERRS) (SERINE TRANSLASE)	Mb3864c, serS, len: 419 aa. Equivalent to Rv3834c,len: 419 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 419 aa overlap). Probable serS,seryl-tRNA synthetase (EC 6.1.1.11), equivalent to Q9CDC1|SERS|ML0082 PUTATIVE SERYL-TRNA SYNTHASE from Mycobacterium leprae (417 aa), FASTA scores: opt: 2361,E(): 8.5e-138, (85.8% identity in 416 aa overlap). Also highly similar many e.g. Q9ZBX1|SYS_STRCO|SERS|SCD78.28c from Streptomyces coelicolor (425 aa), FASTA scores: opt: 1594, E(): 1.2e-90, (59.75% identity in 425 aa overlap); Q9X199|SYS_THEMA|SERS|TM1379 from Thermotoga maritima (425 aa), FASTA scores: opt: 1083, E(): 3.3e-59, (43.3% identity in 425 aa overlap); P37464|SYS_BACSU|SERS from Bacillus subtilis (425 aa), FASTA scores: opt: 1015, E(): 5e-55, (39.3% identity in 425 aa overlap); etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.	X2BQ34,P67562	No									X2BQ34,P67562	P67562									
NC_002945.3	Mycobrowser_v4	CDS	4247978	4248943	.	-	0	Mb3868c	pheA		prephenate dehydratase phea	Mb3868c, pheA, len: 321 aa. Equivalent to Rv3838c,len: 321 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 321 aa overlap). Possible pheA,prephenate dehydratase (EC 4.2.1.51) (see citation below),equivalent to Q9CDC4|PHEA|ML0078 PUTATIVE PREPHENATE DEHYDRATASE from Mycobacterium leprae (322 aa), FASTA scores: opt: 1690, E(): 1.3e-93, (84.25% identity in 311 aa overlap). Also highly similar to others e.g. P10341|PHEA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (315 aa), FASTA scores: opt: 843,E(): 4e-43, (45.8% identity in 308 aa overlap); Q9ZBX0|SCD78.29c from Streptomyces coelicolor (310 aa),FASTA scores: opt: 820, E(): 9.2e-42, (46.45% identity in 312 aa overlap); Q44104|PHEA_AMYME|PDT from Amycolatopsis methanolica (304 aa), FASTA scores: opt: 707, E(): 4.9e-35, (45.7% identity in 313 aa overlap); etc. Contains PS00858 Prephenate dehydratase signature 2.	X2BPX4,Q7TVJ6	No									X2BPX4,Q7TVJ6	Q7TVJ6									
NC_002945.3	Mycobrowser_v4	CDS	4250452	4250997	.	+	0	Mb3871	bfrB		bacterioferritin bfrb	Mb3871, bfrB, len: 181 aa. Equivalent to Rv3841,len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 181 aa overlap). Possible bfrB,bacterioferritin, similar to other ferritin or hypothetical proteins e.g. O26261|MTH158|RSGA FERRITIN LIKE PROTEIN from Methanothermobacter thermautotrophicus (171 aa), FASTA scores: opt: 277, E(): 6.6e-11, (30.1% identity in 166 aa overlap); Q99SZ3|SA1709 HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus N315 (166 aa), FASTA scores: opt: 275, E(): 8.7e-11, (33.35% identity in 156 aa overlap); Q9X0L2|TM1128 FERRITIN from Thermotoga maritima (164 aa), FASTA scores: opt: 247, E(): 5.3e-09, (25.65% identity in 156 aa overlap); Q9KDT7|BH1124 FERRITIN from Bacillus halodurans (169 aa),FASTA scores: opt: 246, E(): 6.3e-09, (28.95% identity in 152 aa overlap); O29424|AF0834 PUTATIVE FERRITIN from Archaeoglobus fulgidu (169 aa), FASTA scores: opt: 246,E(): 6.3e-09, (28.95% identity in 152 aa overlap); etc. Also shows similarity with Rv1876|MTCY180.42|BFRA PROBABLE BACTERIOFERRITIN from Mycobacterium tuberculosis (159 aa). SEEMS BELONG TO THE BACTERIOFERRITIN FAMILY.	Q7TVJ3	No	intermediary metabolism and respiration							IPR001519,IPR008331,IPR009040,IPR009078,IPR012347	Q7TVJ3	A0A1R3Y5E2				Rv3841		Rv3841			
NC_002945.3	Mycobrowser_v4	CDS	4251012	4251836	.	-	0	Mb3872c	glpQ1		PROBABLE GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLPQ1 (GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE)	Mb3872c, glpQ1, len: 274 aa. Equivalent to Rv3842c,len: 274 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 274 aa overlap). Probable glpQ1,glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46),equivalent to Q9CDC5|GLPQ|ML0074 PUTATIVE GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Mycobacterium leprae (271 aa), FASTA scores: opt: 1635,E(): 1.9e-100, (88.85% identity in 269 aa overlap). Also highly similar to others e.g. CAC44700|SCBAC25E3.13c PUTATIVE PHOSPHODIESTERASE from Streptomyces coelicolor (275 aa), FASTA scores: opt: 413, E(): 5.7e-20, (48.05% identity in 258 aa overlap); P37965|GLPQ_BACSU GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Bacillus subtilis (293 aa), FASTA scores: opt: 405, E(): 2e-19,(31.3% identity in 249 aa overlap); Q99VC9|GLPQ|SA0820 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Staphylococcus aureus subsp. aureus N315 (309 aa) FASTA scores: opt: 341, E(): 3.5e-15, (29.3% identity in 273 aa overlap); etc.	Q7TVJ2	No								IPR004129,IPR017946	Q7TVJ2	A0A1R3Y5F5									
NC_002945.3	Mycobrowser_v4	CDS	4279090	4279641	.	+	0	Mb3897	esph		esx-1 secretion-associated protein esph	Mb3897, -, len: 183 aa. Equivalent to Rv3867, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 183 aa overlap). Conserved hypothetical protein, highly similar to the hypothetical proteins from Mycobacterium leprae Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403, E(): 1.8e-18, (48.2% identity in 166 aa overlap); Q49730|ML0407|B1620_C3_264|MLCL383.03 (216 aa), FASTA scores: opt: 517, E(): 1.7e-25, (51.45% identity in 175 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 403, E(): 3.4e-18, (48.2% identity in 166 aa overlap). Also highly similar to O06269|Rv3614c|MTCY07H7B.08 HYPOTHETICAL 19.8 KDA PROTEIN from Mycobacterium tuberculosis (184 aa), FASTA scores: opt: 559, E(): 3.4e-28, (54.35% identity in 173 aa overlap).	Q7TVG9	No	cell wall and cell processes								Q7TVG9	A0A1R3Y5G7				Rv3867		Rv3867			
NC_002945.3	Mycobrowser_v4	CDS	4256977	4257600	.	+	0	Mb3876	sodA		SUPEROXIDE DISMUTASE [FE] SODA	Mb3876, sodA, len: 207 aa. Equivalent to Rv3846,len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 207 aa overlap). sodA (alternate gene names: sodB, sod), superoxyde dismutase (EC 1.15.1.1) (see citations below), equivalent to many e.g. P47201|SODM_MYCAV|SODA|SOD from Mycobacterium avium (206 aa), FASTA scores: opt: 1210, E(): 1.8e-73, (82.5% identity in 206 aa overlap); Q9F9R1|SOD from Mycobacterium paratuberculosis (207 aa), FASTA scores: opt: 1207, E(): 2.9e-73, (81.65% identity in 207 aa overlap); O86165|SODM_MYCLP|SODA|SOD from Mycobacterium lepraemurium (206 aa), FASTA scores: opt: 1204, E(): 4.5e-73, (82.05% identity in 206 aa overlap); P13367|SODM_MYCLE|SODA|ML0072 from Mycobacterium leprae (206 aa), FASTA scores: opt: 1169, E(): 9.6e-71, (80.5% identity in 205 aa overlap); etc. Contains PS00088 Manganese and iron superoxide dismutases signature. BELONGS TO THE IRON/MANGANESE SUPEROXIDE DISMUTASE FAMILY. ALTHOUGH FOUND EXTRACELLULARLY, NO SIGNAL SEQUENCE IS PRESENT. AN ALTERNATIVE SECRETORY PATHWAY MAY BE USED.	X2BPS3,Q7TVI9	No	virulence, detoxification, adaptation								X2BPS3,Q7TVI9	Q7TVI9				Rv3846		Rv3846			
NC_002945.3	Mycobrowser_v4	CDS	4287395	4288501	.	+	0	Mb3903	PPE68		ppe family protein ppe68	Mb3903, PPE68, len: 368 aa. Equivalent to Rv3873,len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 368 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O33085|ML0051|MLCB628.14c from Mycobacterium leprae (302 aa), FASTA scores: opt: 656, E(): 2.8e-24,(46.2% identity in 288 aa overlap); and O53691|Rv0286|MTV035.14 (513 aa), FASTA scores: opt: 566,E(): 7.8e-20, (35.25% identity in 363 aa overlap).	Q7TVG3	No								IPR000030	Q7TVG3	A0A1R3Y6Y1									
NC_002945.3	Mycobrowser_v4	CDS	4259772	4260170	.	+	0	Mb3879	espr		esx-1 transcriptional regulatory protein espr	Mb3879, -, len: 132 aa. Equivalent to Rv3849, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 132 aa overlap). Conserved hypothetical protein, equivalent to Q9CDC9|ML0069 HYPOTHETICAL PROTEIN from Mycobacterium leprae (132 aa) FASTA scores: opt: 724, E(): 8.7e-41, (83.95% identity in 131 aa overlap).	Q7TVI6	No	regulatory proteins							IPR010982	Q7TVI6	A0A1R3Y5I6				Rv3849		Rv3849			
NC_002945.3	Mycobrowser_v4	CDS	4261347	4261751	.	+	0	Mb3882	hns		POSSIBLE HISTONE-LIKE PROTEIN HNS	Mb3882, hns, len: 134 aa. Equivalent to Rv3852,len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 134 aa overlap). Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 HISTONE-LIKE PROTEIN from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 HISTONE H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183, E(): 0.091, (34.85% identity in 109 aa overlap); etc.	Q7TVI3	No	information pathways								Q7TVI3	A0A1R3Y5G5				Rv3852		Rv3852			
NC_002945.3	Mycobrowser_v4	CDS	4261768	4262241	.	+	0	Mb3883	rraa		regulator of rnase e activity a rraa	Mb3883, menG, len: 157 aa. Equivalent to Rv3853,len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 157 aa overlap). Probable menG,S-adenosylmethionine:2-demethylmenaquinone methyltransferase (EC 2.1.-.-), equivalent to Q9CDD2|MENG|ML0066 PUTATIVE S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLTRANSFERASE from Mycobacterium leprae (157 aa) FASTA scores: opt: 896, E(): 1.3e-49, (87.1% identity in 155 aa overlap). Also highly similar to others e.g. Q9S4U0|MENG from Pseudomonas fluorescens (163 aa), FASTA scores: opt: 481, E(): 1.7e-23, (47.0% identity in 149 aa overlap); Q9RW10|DR0859 from Deinococcus radiodurans (160 aa) FASTA scores: opt: 456, E(): 6.3e-22, (45.75% identity in 153 aa overlap); P32165|MENG_ECOLI|B3929|Z5476|ECS4856 from Escherichia coli strain K12 (161 aa), FASTA scores: opt: 428, E(): 3.7e-20, (45.65% identity in 149 aa overlap); etc.	X2BPY0,P0A667	No	regulatory proteins								X2BPY0,P0A667	P0A667				Rv3853		Rv3853			
NC_002945.3	Mycobrowser_v4	CDS	4310219	4311904	.	-	0	Mb3923c	eccc2		POSSIBLE CONSERVED MEMBRANE PROTEIN [SECOND PART]	Mb3923c, -, len: 561 aa. Equivalent to 3' end of Rv3894c, len: 1396 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 561 aa overlap). Possible conserved membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 652, E(): 2.2e-30,(27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa),FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 523, E(): 8.6e-23, (31.65% identity in 1412 aa overlap). Also similar to various proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 973, E(): 2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23,(24.95% identity in 1450 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),FASTA scores: opt: 444, E(): 4.1e-18, (22.5% identity in 1346 aa overlap); etc. Also similar to AAK46103|MT1833 FTSK/SPOIIIE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt: 769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap); and other hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391 aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa overlap) (similarity only with C-terminal end); etc. Contains two possible (PS00017) ATP/GTP-binding sites (P-loop) in central portion. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts, Mb3923c and Mb3924c.	Q7TVE7	No								IPR002543,IPR023837,IPR027417	Q7TVE7	A0A1R3Y6Y5									
NC_002945.3	Mycobrowser_v4	CDS	4262277	4263746	.	-	0	Mb3884c	ethA		MONOOXYGENASE ETHA	Mb3884c, ethA, len: 489 aa. Equivalent to Rv3854c,len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 489 aa overlap). ethA (alternate gene names: aka or etaA), monooxygenase required for activation of the pro-drug ethionamide (EC 1.-.-.-) (see citations below), highly similar to other monooxygenases e.g. Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 1959,E(): 2.9e-114, (57.6% identity in 481 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 1771, E(): 2.2e-102, (53.75% identity in 480 aa overlap); Q9A8K5|CC1348 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (499 aa), FASTA scores: opt: 1385,E(): 1.4e-78, (43.2% identity in 486 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa) FASTA scores: opt: 1692, E(): 1.1e-97, (49.7% identity in 489 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa), FASTA scores: opt: 1571,E(): 3.7e-90, (49.05% identity in 471 aa overlap); O69708|Rv3741c|MTV025.089c POSSIBLE OXIDOREDUCTASE (probably second part of a two component monooxygenase) (224 aa), FASTA scores: opt: 542, E(): 1.7e-26, (50.0% identity in 162 aa overlap); etc.	X2BQ38,Q7TVI2	No									X2BQ38,Q7TVI2	Q7TVI2									
NC_002945.3	Mycobrowser_v4	CDS	4263822	4264472	.	+	0	Mb3885	ethR		TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR	Mb3885, ethR, len: 216 aa. Equivalent to Rv3855,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). ethR (alternate gene names: aka or etaR), regulatory protein tetR family,involved in ethionamide sensitivity/resistance, negatively controls neighbouring ethA (Rv3854c, MTCY01A6.14; alternate gene names: aka etaA) (see citations below). Equivalent to Q9CDD3|ML0064 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (214 aa), FASTA scores: opt: 1017, E(): 7e-62, (77.0% identity in 213 aa overlap). Also similar to other transcriptional regulator e.g. Q9S1R1|SCJ9A.09 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (204 aa), FASTA scores: opt: 305, E(): 1.2e-13, (34.5% identity in 200 aa overlap); Q9KYT9|SCE22.24 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR (FRAGMENT) from Streptomyces coelicolor (244 aa), FASTA scores: opt: 179, E(): 4.9e-05,(35.5% identity in 93 aa overlap); Q9RUK2|DR1384 TRANSCRIPTIONAL REGULATOR (TETR FAMILY) from Deinococcus radiodurans (196 aa), FASTA scores: opt: 167, E(): 0.00026, (41.75% identity in 79 aa overlap); etc. Also similar to P95100|Rv3058c|MTCY22D7.23 HYPOTHETICAL 23.8 KDA PROTEIN from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 261, E(): 1.2e-10, (31.65% identity in 221 aa overlap); and O08377|Rv1534|MTCY07A7A.03 HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium tuberculosis (225 aa),FASTA scores: opt: 164, E(): 0.00047, (25.5% identity in 248 aa overlap). Contains helix-turn-helix motif at aa 45-66, Score 1320 (+3.68 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.	X2BPH1,Q7TVI1	No	regulatory proteins								X2BPH1,Q7TVI1	Q7TVI1				Rv3855		Rv3855			
NC_002945.3	Mycobrowser_v4	CDS	4266312	4267778	.	-	0	Mb3888c	gltD		probable nadh-dependent glutamate synthase (small subunit) gltd (l-glutamate synthase) (l-glutamate synthetase) (nadh-glutamate synthase) (glutamate synthase (nadh)) (glts beta chain) (nadph-gogat)	Mb3888c, gltD, len: 488 aa. Equivalent to Rv3858c,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Probable gltD, small subunit of NADH-dependent glutamate synthase (EC 1.4.1.13), equivalent to Q9CDD4|GLTD|ML0062 NADH-DEPENDENT GLUTAMATE SYNTHASE SMALL SUBUNIT from Mycobacterium leprae (488 aa), FASTA scores: opt: 2997, E(): 1e-166, (87.7% identity in 488 aa overlap). Also highly similar to many e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487 aa), FASTA scores: opt: 2152, E(): 1.2e-117, (63.85% identity in 487 aa overlap); Q9KPJ3|VC2374 from Vibrio cholerae (489 aa), FASTA scores: opt: 1699, E(): 2.5e-91,(51.75% identity in 487 aa overlap); Q03460|GLSN_MEDSA from Medicago sativa (Alfalfa) (2194 aa), FASTA scores: opt: 1322, E(): 6.2e-69, (54.45% identity in 485 aa overlap); P09832|GLTD_ECOLI from strain (471 aa) FASTA scores: opt: 889, E() : 0, (37.4% identity in 473 aa overlap); etc. SIMILAR TO OTHER GLUTAMATE SYNTHASES. COFACTOR: FAD (BY SIMILARITY).	Q7TVH8	No								IPR001327,IPR006005,IPR009051,IPR016040,IPR023753,IPR028261	Q7TVH8	A0A1R3Y5G4									
NC_002945.3	Mycobrowser_v4	CDS	4324398	4324670	.	-	0	Mb3934c	esxE		putative esat-6 like protein esxe (hypothetical alanine rich protein) (esat-6 like protein 12)	Mb3934c, esxE, len: 90 aa. Equivalent to Rv3904c,len: 90 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 90 aa overlap). esxE, putative ESAT-6 like protein 12, hypothetical unknown ala-rich protein. BELONGS TO THE ESAT6 FAMILY.	Q7TVD7	No								IPR010310	Q7TVD7	A0A1R3Y5U3									
NC_002945.3	Mycobrowser_v4	CDS	4274444	4274794	.	-	0	Mb3892c	whiB6		possible transcriptional regulatory protein whib-like whib6	Mb3892c, whiB6, len: 116 aa. Equivalent to Rv3862c,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). Possible whiB6,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Shows similarity with Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL REGULATOR WHIB7 from Mycobacterium leprae (89 aa) FASTA scores: opt: 112, E(): 0.49, (41.2% identity in 51 aa overlap). Some similarity to Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa) FASTA scores: opt: 129, E(): 0.038, (32.95% identity in 85 aa overlap); AAK47632|MT3290.1 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (96 aa), FASTA scores: opt: 126, E(): 0.058, (33.35% identity in 84 aa overlap); Q9FC80|SC4B10.07 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (88 aa), FASTA scores: opt: 119, E(): 0.16, (44.65% identity in 70 aa overlap); Q9K4K8|SC5F8.16c REGULATORY PROTEIN from Streptomyces coelicolor (83 aa), FASTA scores: opt: 114,E(): 0.34, (37.05% identity in 54 aa overlap); etc.	Q7TVH4	No								IPR003482	Q7TVH4	A0A1R3Y5I2									
NC_002945.3	Mycobrowser_v4	CDS	4276542	4277798	.	+	0	Mb3894	espe		esx-1 secretion-associated protein espe	Mb3894, -, len: 418 aa. Equivalent to Rv3864, len: 402 aa, from Mycobacterium tuberculosis strain H37Rv,(96.2% identity in 418 aa overlap). Conserved hypothetical protein, similar to Q49722|ML0405|B1620_C2_213|MLCL383.01 HYPOTHETICAL 40.8 KDA PROTEIN from Mycobacterium leprae (394 aa) FASTA scores: opt: 397, E(): 1.2e-12, (31.0% identity in 410 aa overlap). Also similar to various proteins from several organisms e.g. Q9VYF9|CG12723 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (450 aa), FASTA scores: opt: 291, E(): 2.3e-07,(34.6% identity in 130 aa overlap); Q98UE3 PROCOLLAGEN ALPHA1(III) (FRAGMENT) from Xenopus laevis (African clawed frog) (117 aa) FASTA scores: opt: 257, E(): 3.6e-06,(41.75% identity in 103 aa overlap); P27393|CA24_ASCSU COLLAGEN ALPHA 2(IV) CHAIN PRECURSOR from Ascaris suum (Pig roundworm) (Ascaris lumbricoides) (1763 aa), FASTA scores: opt: 273, E(): 5.7e-06, (32.1% identity in 240 aa overlap); etc. Also similar to O06267|Rv3616c|MTCY07H7B.06 (392 aa) FASTA scores: opt: 389, E(): 3e-12, (31.6% identity in 399 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 36 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa).	Q7TVH2	No	cell wall and cell processes								Q7TVH2	A0A1R3Y5Q3				Rv3864		Rv3864			
NC_002945.3	Mycobrowser_v4	CDS	4277886	4278197	.	+	0	Mb3895	espf		esx-1 secretion-associated protein espf	Mb3895, -, len: 103 aa. Equivalent to Rv3865, len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 103 aa overlap). Conserved hypothetical protein, showing some similarity to O06268|Rv3615c|MTCY07H7B.07 HYPOTHETICAL 10.8 KDA PROTEIN from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 198, E(): 7.5e-07, (36.25% identity in 102 aa overlap); Q49723|ML0406|B1620_C2_214|MLCL383.02 HYPOTHETICAL 11.1 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 154, E(): 0.00071, (31.05% identity in 103 aa overlap).	Q7TVH1	No	cell wall and cell processes							IPR022536	Q7TVH1	A0A1R3Y5H6				Rv3865		Rv3865			
NC_002945.3	Mycobrowser_v4	CDS	4278200	4279051	.	+	0	Mb3896	espg1		esx-1 secretion-associated protein espg1	Mb3896, -, len: 283 aa. Equivalent to Rv3866, len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 283 aa overlap). Conserved hypothetical protein. N-terminal end highly similar to O33091|MLCB628.20c HYPOTHETICAL 13.1 KDA PROTEIN from Mycobacterium leprae (122 aa), FASTA scores: opt: 260,E(): 2.1e-09, (43.6% identity in 117 aa overlap); and C-terminal end highly similar to O33090|MLCB628.19c HYPOTHETICAL 36.7 KDA PROTEIN from Mycobacterium leprae (338 aa), FASTA scores: opt: 540, E(): 1.4e-26, (54.5% identity in 156 aa overlap). Also similar to Q9CD34|ML2530 POSSIBLE DNA-BINDING PROTEIN from Mycobacterium leprae (289 aa), FASTA scores: opt: 146, E(): 0.058, (28.25% identity in 269 aa overlap) and O53694|Rv0289|MTV035.17 HYPOTHETICAL 31.6 KDA PROTEIN from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 133, E(): 0.39,(28.15% identity in 277 aa overlap).	Q7TVH0	No	cell wall and cell processes							IPR025734	Q7TVH0	A0A1R3Y5H0				Rv3866		Rv3866			
NC_002945.3	Mycobrowser_v4	CDS	4279634	4281355	.	+	0	Mb3898	ecca1		esx conserved component ecca1. esx-1 type vii secretion system protein.	Mb3898, -, len: 573 aa. Equivalent to Rv3868, len: 573 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 573 aa overlap). Member of the CBXX/CFQX family of hypothetical proteins; C-terminal end is highly similar to many e.g. P40118|CBXC_ALCEU|CBXXC|CFXXC CBXX PROTEIN (317 aa) FASTA scores: opt: 572, E(): 3e-24, (42.7% identity in 294 aa overlap); CAC48589 PROBABLE CBBX PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (311 aa) FASTA scores: opt: 569, E(): 4.3e-24, (40.05% identity in 292 aa overlap); P95648|CBBX_RHOSH CBBX PROTEIN from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (309 aa), FASTA scores: opt: 559, E(): 1.5e-23, (41.4% identity in 290 aa overlap); etc. Equivalent to O33089|Y2G8_MYCLE|ML0055|MLCB628.18c HYPOTHETICAL 62.3 KDA PROTEIN from Mycobacterium leprae (573 aa), FASTA scores: opt: 3330, E(): 3.9e-175, (89.2% identity in 573 aa overlap); and similar to Q9CD28|Y282_MYCLE|ML2537 HYPOTHETICAL 69.1 KDA PROTEIN from Mycobacterium leprae (640 aa), FASTA scores: opt: 943, E(): 2.4e-44, (37.5% identity in 571 aa overlap). Also similar to many proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 936, E(): 5.8e-44, (39.05% identity in 568 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).	Q7TVG8	No	cell wall and cell processes							IPR000641,IPR003593,IPR003959,IPR023835,IPR027417	Q7TVG8	A0A1R3Y5H4				Rv3868		Rv3868			
NC_002945.3	Mycobrowser_v4	CDS	4281359	4282801	.	+	0	Mb3899	eccb1		esx conserved component eccb1. esx-1 type vii secretion system protein. possible membrane protein.	Mb3899, -, len: 480 aa. Equivalent to Rv3869, len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Possible conserved membrane protein (has hydrophobic stretch near N-terminus), equivalent to O33088|ML0054|MLCB628.17c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (481 aa), FASTA scores: opt: 2489, E(): 8.3e-136, (75.75% identity in 478 aa overlap); and similar to others e.g. Q9Z5I3|ML1544|MLCB596.27 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (506 aa), FASTA scores: opt: 739,E(): 3.9e-35, (33.65% identity in 490 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. O05449|Rv3895c|MTCY15F10.17 (495 aa),FASTA scores: opt: 795, E(): 2.3e-38, (35.8% identity in 486 aa overlap); O53933|Rv1782|MTV049.04 (506 aa), FASTA scores: opt: 763, E(): 1.6e-36, (34.7% identity in 490 aa overlap); O06317|Rv3450c|MTCY13E12.03c (470 aa) FASTA scores: opt: 717, E(): 6.7e-34, (32.55% identity in 479 aa overlap); etc.	Q7TVG7	No	cell wall and cell processes							IPR007795	Q7TVG7	A0A1R3Y5K0				Rv3869		Rv3869			
NC_002945.3	Mycobrowser_v4	CDS	4285147	4286922	.	+	0	Mb3901	ecccb1		esx conserved component ecccb1. esx-1 type vii secretion system protein.	Mb3901, -, len: 591 aa. Equivalent to Rv3871, len: 591 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 591 aa overlap). Conserved hypothetical protein, equivalent to Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa) FASTA scores: opt: 3341, E(): 9.8e-192, (80.85% identity in 596 aa overlap); and O33086|MLCB628.15c HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 3329, E(): 5.1e-191, (80.55% identity in 596 aa overlap). And similar to C-terminal end of others e.g. Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 601, E(): 5.6e-28, (32.3% identity in 613 aa overlap); O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 977,E(): 2.1e-50, (35.15% identity in 583 aa overlap); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 414, E(): 9e-17, (27.6% identity in 424 aa overlap);P71068|YUKA YUKA PROTEIN from Bacillus subtilis (1207 aa), FASTA scores: opt: 343, E(): 1.3e-12, (25.8% identity in 395 aa overlap); etc. And similar to to C-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O06264|Rv3447c|MTCY77.19c (1236 aa) FASTA scores: opt: 845, E(): 1.5e-42, (35.3% identity in 586 aa overlap); O53689|Rv0284|MTV035.12 (1330 aa) FASTA scores: opt: 646, E(): 1.2e-30, (33.35% identity in 606 aa overlap); O53935|Rv1784|MTV049.06 (932 aa) FASTA scores: opt: 589, E(): 2.1e-27, (33.1% identity in 619 aa overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in upstream ORF MTV027.05.	Q7TVG5	No	cell wall and cell processes							IPR002543,IPR003593,IPR023837,IPR027417	Q7TVG5	A0A1R3Y5I0				Rv3871		Rv3871			
NC_002945.3	Mycobrowser_v4	CDS	4287065	4287361	.	+	0	Mb3902	PE35		pe family-related protein pe35	Mb3902, PE35, len: 98 aa. Equivalent to Rv3872,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 98 aa overlap). Some similarity to Mycobacterium tuberculosis conserved PE family proteins,e.g. O69713|Rv3746c|MTV025.094c (111 aa), FASTA scores: opt: 306, E(): 5.5e-13, (50.5% identity in 99 aa overlap). Equivalent to AAK48354 from Mycobacterium tuberculosis strain CDC1551 (112 aa) but shorter 14 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (g-t) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (98 aa versus 99 aa).	Q7TVG4	No	PE/PPE							IPR000084	Q7TVG4	A0A1R3Y5I3				Rv3872		Rv3872			
NC_002945.3	Mycobrowser_v4	CDS	4296564	4296911	.	-	0	Mb3910c	espl		esx-1 secretion-associated protein espl	Mb3910c, -, len: 115 aa. Equivalent to Rv3880c,len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 115 aa overlap). Conserved hypothetical protein, equivalent to O33080|ML0044|MLCB628.09 HYPOTHETICAL 12.2 KDA PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 397, E(): 2e-19, (56.35% identity in 110 aa overlap).	Q7TVF8	No	cell wall and cell processes							IPR004401	Q7TVF8	A0A1R3Y5I7				Rv3880c		Rv3880c			
NC_002945.3	Mycobrowser_v4	CDS	4288594	4288896	.	+	0	Mb3904	esxB		10 kda culture filtrate antigen esxb (lhp) (cfp10)	Mb3904, esxB, len: 100 aa. Equivalent to Rv3874,len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 100 aa overlap). esxB (alternate gene name: cfp10), 10 KDA culture filtrate antigen (see citations below, especially first), highly similar to O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA CULTURE FILTRATE ANTIGEN CFP10 HOMOLOG from Mycobacterium leprae (99 aa), FASTA scores: opt: 237, E(): 2.4e-08, (39.4% identity in 99 aa overlap). Also similar to O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 PUTATIVE ESAT-6 LIKE PROTEIN 13 from Mycobacterium tuberculosis (103 aa) FASTA scores: opt: 126, E(): 0.18, (23.1% identity in 91 aa overlap); and shows some similarity with other proteins from Mycobacterium tuberculosis. Contains probable coiled-coil from aa 49-93. BELONGS TO THE ESAT6 FAMILY.	X2BQ42,P0A567	No	cell wall and cell processes								X2BQ42,P0A567	P0A567				Rv3874		Rv3874			
NC_002945.3	Mycobrowser_v4	CDS	4296908	4298290	.	-	0	Mb3911c	espb		secreted esx-1 substrate protein b, espb. conserved alanine and glycine rich protein	Mb3911c, -, len: 460 aa. Equivalent to Rv3881c,len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 460 aa overlap). Conserved hypothetical ala-, gly-rich protein. C-terminal end highly similar to O06126 HYPOTHETICAL 9.5 KDA PROTEIN (FRAGMENT) from Mycobacterium tuberculosis strain NTI 64719 (90 aa) FASTA scores: opt: 333, E(): 6.3e-07, (69.75% identity in 86 aa overlap) but sequence difference causes frameshift in NTI 64719. Also similar to part of small Mycobacterium leprae ORF O33078|MLCB628.06 (EMBL:Y14967) (101 aa), FASTA scores: opt: 194, E(): 0.04, (59.3% identity in 54 aa overlap), suggesting this is represented by a pseudogene in M. leprae.	Q7TVB3	No	cell wall and cell processes								Q7TVB3	A0A1R3Y5I4				Rv3881c		Rv3881c			
NC_002945.3	Mycobrowser_v4	CDS	4288929	4289216	.	+	0	Mb3905	esxA		6 kda early secretory antigenic target esxa (esat-6)	Mb3905, esxA, len: 95 aa. Equivalent to Rv3875,len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 95 aa overlap). esxA, Early Secretory Antigenic Target (see citations below), identical to Q57165|O84901|ESAT6 EARLY SECRETORY ANTIGENIC TARGET from Mycobacterium bovis (94 aa), FASTA scores: opt: 596, E(): 4.6e-33, (100.0% identity in 94 aa overlap). Also similar to Q50206|ESA6_MYCLE|ESAT6|ESX|L45|ML0049|MLCB628.12c 6 KDA EARLY SECRETORY ANTIGENIC TARGET HOMOLOG (ESAT-6-LIKE PROTEIN) (L-ESAT) from Mycobacterium leprae (95 aa), FASTA scores: opt: 236, E(): 3.3e-09, (36.25% identity in 91 aa overlap); and weak similarity with others proteins ESAT-like from Mycobacterium leprae. Also some similarity with O53266|ES69_MYCTU|Rv3019c|MT3104|MTV012.33c PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 131, E(): 0.03,(26.15% identity in 88 aa overlap); and other ESAT-like protein. Contains probable coiled-coil from 56 to 92 aa. BELONGS TO THE ESAT6 FAMILY.	X2BPJ5,P0A565	No	cell wall and cell processes								X2BPJ5,P0A565	P0A565				Rv3875		Rv3875			
NC_002945.3	Mycobrowser_v4	CDS	4289330	4291330	.	+	0	Mb3906	espi		esx-1 secretion-associated protein espi. conserved proline and alanine rich protein.	Mb3906, -, len: 666 aa. Equivalent to Rv3876, len: 666 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 666 aa overlap). Conserved hypothetical pro-, ala-rich protein, similar to several proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 HYPOTHETICAL PROTEIN (586 aa), FASTA scores: opt: 1682,E(): 2.1e-45, (50.75% identity in 672 aa overlap); O33082|MLCB628.11c HYPOTHETICAL 52.0 KDA PROTEIN (478 aa),FASTA scores: opt: 1588, E(): 1.5e-42, (53.5% identity in 542 aa overlap) (also has a proline rich N-terminus); etc. Also similar to other proteins from Mycobacterium tuberculosis, especially in C-terminus, e.g. O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 670, E(): 2.5e-14, (34.85% identity in 396 aa overlap) (also has Pro-rich N-terminus); etc. Note that N-terminus is repetitive and highly Proline rich.	Q7TVG2	No	cell wall and cell processes							IPR025669,IPR027417	Q7TVG2	A0A1R3Y5I8				Rv3876		Rv3876			
NC_002945.3	Mycobrowser_v4	CDS	4301344	4303203	.	-	0	Mb3914c	ecca2		esx conserved component ecca2. esx-2 type vii secretion system protein. probable cbxx/cfqx family protein.	Mb3914c, -, len: 619 aa. Equivalent to Rv3884c,len: 619 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 619 aa overlap). Putative CBXX/CFQX protein family, similar to hypothetical proteins from Mycobacterium leprae e.g. Q9CD28|Y282_MYCLE|ML2537 (640 aa), FASTA scores: opt: 725, E(): 2.9e-34, (28.95% identity in 587 aa overlap); O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (BELONGS TO THE CBXX/CFQX FAMILY) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa overlap). Also similar to proteins belonging to the CBXX/CFQX FAMILY e.g. Q9RKZ2|SC6D7.05c PUTATIVE CBXX/CFQX FAMILY PROTEIN from Streptomyces coelicolor (618 aa) FASTA scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ STAGE V SPORULATION PROTEIN K from Bacillus subtilis (322 aa) FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in 280 aa overlap) (similarity only at C-terminus); Q9KAC6|BH2363 STAGE V SPORULATION PROTEIN K from Bacillus halodurans (315 aa), FASTA scores: opt: 462, E(): 2.2e-19,(36.05% identity in 244 aa overlap) (similarity only at C-terminus); etc. And similar to hypothetical proteins from Mycobacterium tuberculosis belonging to the CBXX/CFQX FAMILY e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 743, E(): 2.6e-35, (29.9% identity in 612 aa overlap); O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 HYPOTHETICAL 62.4 KDA PROTEIN (573 aa), FASTA scores: opt: 678, E(): 1.3e-31, (31.25% identity in 589 aa overlap); O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SEEMS TO BELONG TO THE CBXX/CFQX FAMILY.	X2BQ44,P59976	No	cell wall and cell processes								X2BQ44,P59976	P59976				Rv3884c		Rv3884c			
NC_002945.3	Mycobrowser_v4	CDS	4291327	4292862	.	+	0	Mb3907	eccd1		esx conserved component eccd1. esx-1 type vii secretion system protein. probable transmembrane protein.	Mb3907, -, len: 511 aa. Equivalent to Rv3877, len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 511 aa overlap). Probable conserved transmembrane protein, equivalent to Q9CDD9|ML0047 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (512 aa), FASTA scores: opt: 2496, E(): 2.8e-140, (74.0% identity in 512 aa overlap); and highly similar, but longer 32 aa, to O33081|MLCB628.10c HYPOTHETICAL 51.4 KDA PROTEIN from Mycobacterium leprae (480 aa), FASTA scores: opt: 2346, E(): 2e-131, (74.15% identity in 480 aa overlap). Shows also similarity with other membrane proteins from Mycobacterium leprae e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 318, E(): 2e-11, (22.7% identity in 520 aa overlap). Also similar to various proteins from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 391, E(): 9.4e-16, (24.45% identity in 523 aa overlap); O86362|Rv0290|MTV035.18 HYPOTHETICAL 47.9 KDA PROTEIN (472 aa), FASTA scores: opt: 332, E(): 2.8e-12, (28.1% identity in 509 aa overlap); O05457|Rv3887c|MTCY15F10.25 HYPOTHETICAL 53.2 KDA PROTEIN (509 aa), FASTA scores: opt: 167, E(): 0.017, (24.0% identity in 517 aa overlap); etc. Equivalent to AAK48359 from Mycobacterium tuberculosis strain CDC1551 (479 aa) but longer 32 aa.	Q7TVG1	No	cell wall and cell processes							IPR006707,IPR024962	Q7TVG1	A0A1R3Y5H5				Rv3877		Rv3877			
NC_002945.3	Mycobrowser_v4	CDS	4293013	4293855	.	+	0	Mb3908	espj		esx-1 secretion-associated protein espj. conserved alanine rich protein.	Mb3908, -, len: 280 aa. Equivalent to Rv3878, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 280 aa overlap). Hypothetical unknown ala-rich protein.	Q7TVG0	No	cell wall and cell processes								Q7TVG0	A0A1R3Y5H9				Rv3878		Rv3878			
NC_002945.3	Mycobrowser_v4	CDS	4293913	4296147	.	-	0	Mb3909c	espk		esx-1 secretion-associated protein espk. alanine and proline rich protein.	Mb3909c, -, len: 744 aa. Equivalent to Rv3879c,len: 729 aa, from Mycobacterium tuberculosis strain H37Rv,(98.0% identity in 743 aa overlap). Hypothetical unknown ala-, pro-rich protein (N-terminal end is repetitive and highly Proline-rich). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, insertions of 27 bp and 18 bp lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (744 aa versus 729 aa).	Q7TVF9	No	cell wall and cell processes							IPR010310	Q7TVF9	A0A1R3Y5K9				Rv3879c		Rv3879c			
NC_002945.3	Mycobrowser_v4	CDS	4298397	4299785	.	-	0	Mb3912c	ecce1		esx conserved component ecce1. esx-1 type vii secretion system protein. possible membrane protein.	Mb3912c, -, len: 462 aa. Equivalent to Rv3882c,len: 462 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 462 aa overlap). Possible conserved membrane protein, equivalent to O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 2346, E(): 1.1e-140, (72.1% identity in 462 aa overlap). Also similar to O05459|Rv3885c|MTCY15F10.27 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (537 aa) FASTA scores: opt: 283, E(): 2.5e-10, (26.8% identity in 414 aa overlap); and C-terminal end shows similarity with AAK48368|MT4000 HYPOTHETICAL 45.6 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (422 aa) FASTA scores: opt: 215, E(): 4.1e-06, (26.85% identity in 320 aa overlap).	Q7TVF7	No	cell wall and cell processes							IPR021368	Q7TVF7	A0A1R3Y5J6				Rv3882c		Rv3882c			
NC_002945.3	Mycobrowser_v4	CDS	4299782	4301122	.	-	0	Mb3913c	mycp1		membrane-anchored mycosin mycp1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1)	Mb3913c, -, len: 446 aa. Equivalent to Rv3883c,len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 446 aa overlap). Possible secreted protease (EC 3.4.-.-), equivalent to O33076|ML0041|MLCB628.04 PROBABLE SECRETED PROTEASE from Mycobacterium leprae (446 aa), FASTA scores: opt: 2448,E(): 1.5e-124, (79.15% identity in 446 aa overlap); and highly similar, but in part, to several putative proteases from Mycobacterium leprae; Q9CBV3|ML1538 (567 aa) FASTA scores: opt: 902, E(): 3e-41, (37.25% identity in 556 aa overlap); and Q9CD36|ML2528 (475 aa), FASTA scores: opt: 873, E(): 9.4e-40, (42.7% identity in 459 aa overlap). Shows also similarity with several proteases from other organisms e.g. Q9PCD0|XF1851 SERINE PROTEASE from Xylella fastidiosa (1000 aa), FASTA scores: opt: 281, E(): 1.3e-07, (27.95% identity in 422 aa overlap); P42780|BPRX_BACNO EXTRACELLULAR SUBTILISIN-LIKE PROTEASE PRECURSOR (EC 3.4.21.-) from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 270,E(): 3.2e-07, (28.9% identity in 384 aa overlap); Q46541|APRV5 ACIDIC PROTEASE V5 from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 264,E(): 6.8e-07, (28.65% identity in 384 aa overlap); etc. Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53695|Rv0291|MTV035.19 PUTATIVE PROTEASE (461 aa), FASTA scores: opt: 1168, E(): 1.2e-55,(44.6% identity in 453 aa overlap); O53945|Rv1796|MTV049.18 HYPOTHETICAL 60.0 KDA PROTEIN (585 aa), FASTA scores: opt: 928, E(): 1.2e-42, (37.85% identity in 555 aa overlap) (note gap from aa 155-264); and downstream ORF O05458|Rv3886c|MTCY15F10.26 HYPOTHETICAL 55.6 KDA PROTEIN (550 aa), FASTA scores: opt: 910, E(): 1.1e-41, (40.15% identity in 533 aa overlap) (note partial gap from aa 146-234); etc. Equivalent to AAK48366 from Mycobacterium tuberculosis strain CDC1551 (411 aa) but longer 35 aa. Has signal sequence with possible signal peptidase I cleavage site in residues 19-21 (ASA) and hydrophobic stretch at C-terminus,followed by short positively charged segment, that could act as membrane anchor.	Q7TVF6	No	intermediary metabolism and respiration							IPR000209,IPR015500,IPR023834	Q7TVF6	A0A1R3Y6Y3				Rv3883c		Rv3883c			
NC_002945.3	Mycobrowser_v4	CDS	4303273	4304886	.	-	0	Mb3915c	ecce2		esx conserved component ecce2. esx-2 type vii secretion system protein. possible membrane protein.	Mb3915c, -, len: 537 aa. Equivalent to Rv3885c,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 537 aa overlap). Possible conserved membrane protein (has hydrophobic stretch near N-terminus), showing some similarity with O05462|Rv3882c|MTV027.17c|MTCY15F10.30 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (462 aa) FASTA scores: opt: 283, E(): 8.3e-10, (26.55% identity in 414 aa overlap); and O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 260, E(): 2.1e-08, (28.0% identity in 382 aa overlap). Equivalent to AAK48368 from Mycobacterium tuberculosis strain CDC1551 (422 aa) but longer 115 aa.	Q7TVF5	No	cell wall and cell processes							IPR021368	Q7TVF5	A0A1R3Y5J7				Rv3885c		Rv3885c			
NC_002945.3	Mycobrowser_v4	CDS	4304883	4306535	.	-	0	Mb3916c	mycp2		probable alanine and proline rich membrane-anchored mycosin mycp2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2)	Mb3916c, -, len: 550 aa. Equivalent to Rv3886c,len: 550 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 550 aa overlap). Probable ala-,pro-rich protease (EC 3.4.-.-), highly similar to Q9CBV3|ML1538 POSSIBLE PROTEASE from Mycobacterium leprae (567 aa), FASTA scores: opt: 1034, E(): 3.9e-32, (43.5% identity in 575 aa overlap); and highly similar, but with gaps, to several putative proteases from Mycobacterium leprae; O33076|ML0041|MLCB628.04 (446 aa), FASTA scores: opt: 860, E(): 1.1e-25, (38.65% identity in 538 aa overlap); Q9CD36|ML2528 (475 aa) (475 aa), FASTA scores: opt: 413, E(): 7.1e-09, (37.7% identity in 562 aa overlap). Also similarity with Q99405|PRTM_BACSP M-PROTEASE (EC 3.4.21.-) from Bacillus sp. strain KSM-K16 (269 aa), FASTA scores: E(): 7.6e-06, (27.1% identity in 277 aa overlap). And highly similar, but also with gaps,to hypothetical proteins from Mycobacterium tuberculosis e.g. O53945|Rv1796|MTV049.18 (585 aa), FASTA scores: opt: 1173, E(): 2.4e-37, (47.9% identity in 578 aa overlap); the upstream ORF O05461|Rv3883c|MTCY15F10.29 (446 aa) FASTA scores: opt: 910, E(): 1.5e-27, (40.15% identity in 533 aa overlap); O06316|Rv3449|MTCY13E12.02 (455 aa) FASTA scores: opt: 477, E(): 2.7e-11, (38.75% identity in 550 aa overlap); etc. Pro rich protein with two serine protease,subtilase family active site motifs: aspartic acid active site motif (PS00136); and histidine active site motif (PS00137). BELONGS TO PEPTIDASE FAMILY S8; ALSO KNOWN AS THE SUBTILASE FAMILY.	Q7TVF4	No	intermediary metabolism and respiration							IPR000209,IPR015500,IPR023827,IPR023834	Q7TVF4	A0A1R3Y5J2				Rv3886c		Rv3886c			
NC_002945.3	Mycobrowser_v4	CDS	4306520	4307389	.	-	0	Mb3917c	eccd2		esx conserved component eccd2. esx-2 type vii secretion system protein. probable transmembrane protein.	Mb3917c, -, len: 289 aa. Equivalent to 3' end of Rv3887c, len: 509 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 288 aa overlap). Probable conserved transmembrane protein (has hydrophilic stretch from ~1-130 then very hydrophobic domain), similar to other membrane proteins and with weak similarity to known transporters, e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN from Mycobacterium leprae (503 aa), FASTA scores: opt: 395, E(): 2.3e-16, (28.0% identity in 496 aa overlap); Q9CD35|ML2529 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (485 aa), FASTA scores: opt: 221,E(): 6.6e-06, (24.6% identity in 423 aa overlap); Q9ADP8|2SC10A7.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (430 aa), FASTA scores: opt: 171,E(): 0.0062, (26.55% identity in 358 aa overlap); CAC44275|SCBAC17F8.03 PUTATIVE DRUG EFFLUX PROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 160,E(): 0.028, (27.85% identity in 323 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 360, E(): 2.9e-14, (26.65% identity in 514 aa overlap); etc. Equivalent to AAK48369 from Mycobacterium tuberculosis strain CDC1551 (469 aa) but longer 40 aa. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 2406 bp leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv.	Q7TVF3	No								IPR006707	Q7TVF3	A0A1R3Y5J4									
NC_002945.3	Mycobrowser_v4	CDS	4307371	4307589	.	-	0	Mb3918c	espg2		esx-2 secretion-associated protein espg2	Mb3918c, -, len: 72 aa. Equivalent to 5' end of Rv3889c, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 68 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv.	Q7TVF2	No								IPR025734	Q7TVF2	A0A1R3Y5I9									
NC_002945.3	Mycobrowser_v4	CDS	4307597	4307971	.	-	0	Mb3919c	esxC		esat-6 like protein esxc (esat-6 like protein 11)	Mb3919c, esxC, len: 124 aa. Similar to Rv3890c,len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 55 aa overlap). esxC, putative ESAT-6 like protein 11, equivalent to Q9K548|ES6B_MYCPA PUTATIVE ESAT-6 LIKE PROTEIN 11 (ORF3890C) from Mycobacterium paratuberculo sis (95 aa), FASTA scores: opt: 490, E(): 3.3e-26, (76.85% identity in 95 aa overlap). BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (125 aa versus 95 aa).	Q7TVF1	No								IPR010310,IPR020167	Q7TVF1	A0A1R3Y5L3									
NC_002945.3	Mycobrowser_v4	CDS	4308007	4308330	.	-	0	Mb3920c	esxD		possible esat-6 like protein esxd	Mb3920c, esxD, len: 107 aa. Equivalent to Rv3891c,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(99.1% identity in 107 aa overlap). esxD, conserved hypothetical protein, equivalent to Q9K547 HYPOTHETICAL 10.3 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (100 aa), FASTA scores: opt: 498, E(): 1.7e-26, (77.25% identity in 101 aa overlap).	Q7TVF0	No								IPR010310	Q7TVF0	A0A1R3Y5J9									
NC_002945.3	Mycobrowser_v4	CDS	4308441	4309640	.	-	0	Mb3921c	PPE69		ppe family protein ppe69	Mb3921c, PPE69, len: 399 aa. Equivalent to Rv3892c,len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 399 aa overlap). Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348, E(): 2.2e-08, (26.6% identity in 380 aa overlap).	Q7TVE9	No								IPR000030	Q7TVE9	A0A1R3Y5J8									
NC_002945.3	Mycobrowser_v4	CDS	4309719	4309952	.	-	0	Mb3922c	PE36		pe family protein pe36	Mb3922c, PE36, len: 77 aa. Equivalent to Rv3893c,len: 77 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 77 aa overlap). Member of the Mycobacterium tuberculosis PE family of conserved proteins, similar to other e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap).	Q7TVE8	No								IPR000084	Q7TVE8	A0A1R3Y5M8									
NC_002945.3	Mycobrowser_v4	CDS	4314411	4315898	.	-	0	Mb3925c	eccb2		esx conserved component eccb2. esx-2 type vii secretion system protein. probable membrane protein.	Mb3925c, -, len: 495 aa. Equivalent to Rv3895c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Possible conserved membrane protein, highly similar to two CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae: Q9Z5I3|ML1544|MLCB596.27 (506 aa), FASTA scores: opt: 1070, E(): 1.4e-53, (39.8% identity in 485 aa overlap); and Q9CD29|ML2536 (552 aa), FASTA scores: opt: 483, E(): 4e-20, (36.85% identity in 499 aa overlap). Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53933|Rv1782|MTV049.04 HYPOTHETICAL PROTEIN (506 aa), FASTA scores: opt: 1106, E(): 1.2e-55,(41.25% identity in 485 aa overlap); O69734|Rv3869|MTV027.04 HYPOTHETICAL PROTEIN (480 aa),FASTA scores: opt: 795, E(): 6.1e-38, (36.0% identity in 486 aa overlap); O33088|ML0054|MLCB628.17c PUTATIVE MEMBRANE PROTEIN) (481 aa), FASTA scores: opt: 740, E(): 8.3e-35, (35.65% identity in 485 aa overlap); etc.	Q7TVE5	No	cell wall and cell processes							IPR007795	Q7TVE5	A0A1R3Y5K7				Rv3895c		Rv3895c			
NC_002945.3	Mycobrowser_v4	CDS	4324819	4324992	.	-	0	Mb3935c	esxF		putative esat-6 like protein esxf (hypothetical alanine and glycine rich protein) (esat-6 like protein 13)	Mb3935c, esxF, len: 57 aa. Equivalent to Rv3905c,len: 103 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 57 aa overlap). esxF, putative ESAT-6 like protein 13, hypothetical unknown ala-, gly-rich protein, ESAT-6 like protein. BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (g-a) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa).	Q7TVD6	No								IPR010310	Q7TVD6	A0A1R3Y5L4									
NC_002945.3	Mycobrowser_v4	CDS	4325592	4327034	.	-	0	Mb3937c	pcnA		probable poly(a) polymerase pcna (polynucleotide adenylyltransferase) (ntp polymerase) (rna adenylating enzyme) (poly(a) polymerase)	Mb3937c, pcnA, len: 480 aa. Equivalent to Rv3907c,len: 480 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 480 aa overlap). Probable pcnA,polynucleotide polymerase (EC 2.7.7.19), equivalent to Q9CCY1|PCNA|ML2697 PCNA PROTEIN from Mycobacterium leprae (486 aa), FASTA scores: opt: 2713, E(): 4.3e-160, (84.1% identity in 478 aa overlap); and Q59534|PCNB POLYA POLYMERASE from Mycobacterium leprae (411 aa) FASTA scores: opt: 2077, E(): 7.1e-121, (82.55% identity in 373 aa overlap). Also highly similar to many e.g. Q9X8T2|SCH24.18 PUTATIVE RNA NUCLEOTIDYLTRANSFERASE from Streptomyces coelicolor (483 aa), FASTA scores: opt: 1856,E(): 3.7e-107, (61.55% identity in 455 aa overlap); Q9ZN65 POLYA POLYMERASE from Prevotella ruminicola (Bacteroides ruminicola) (479 aa), FASTA scores: opt: 830, E(): 8.5e-44, (34.85% identity in 445 aa overlap); P42977|PAPS_BACSU POLY(A) POLYMERASE from Bacillus subtilis (397 aa), FASTA scores: opt: 479, E(): 3.5e-22,(29.35% identity in 450 aa overlap); etc. Contains: PS00017 ATP/GTP-binding site motif A (P-loop), PS00018 EF-hand calcium-binding domain, and probably less significant a PS00237 G-protein coupled receptor signature, and PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. BELONGS TO THE TRNA NUCLEOTIDYLTRANSFERASE / POLY(A) POLYMERASE FAMILY.	Q7TVD4	No								IPR002646,IPR003607,IPR006674,IPR006675,IPR014065	Q7TVD4	A0A1R3Y5L0									
NC_002945.3	Mycobrowser_v4	CDS	4327410	4328156	.	+	0	Mb3938	mutt4		possible mutator protein mutt4	Mb3938, -, len: 248 aa. Equivalent to Rv3908, len: 248 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 248 aa overlap). Conserved hypothetical protein, equivalent to Q50195|ML2698|L222-ORF6 HYPOTHETICAL PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 1270,E(): 3.4e-62, (79.05% identity in 248 aa overlap). Also similar to O66548|APFA|AQ_158 HYDROLASE from Aquifex aeolicus (134 aa), FASTA scores: opt: 300, E(): 1.1e-09,(37.3% identity in 142 aa overlap); and similarity with other various proteins e.g. O93721 DIADENOSINE 5'5'''-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Pyrobaculum aerophilum (143 aa), FASTA scores: opt: 205,E(): 0.00017, (34.85% identity in 109 aa overlap); Q9HS29|APA|VNG0431G DIADENOSINE TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Halobacterium sp. strain NRC-1 (142 aa), FASTA scores: opt: 199, E(): 0.00036, (34.0% identity in 147 aa overlap); Q9YA58|APE2080 HYPOTHETICAL 19.2 KDA PROTEIN from Aeropyrum pernix (175 aa) FASTA scores: opt: 191, E(): 0.0012, (36.9% identity in 141 aa overlap); etc. Also similar to P95110|MUTT1|Rv2985|MTCY349.02 HYPOTHETICAL 34.7 KDA PROTEIN from Mycobacterium tuberculosis (317 aa) FASTA scores: opt: 224, E(): 3e-05, (34.05% identity in 144 aa overlap).	Q7TVD3	No	information pathways							IPR015797,IPR020084,IPR020476,IPR000086	Q7TVD3	A0A1R3Y5K6				Rv3908		Rv3908			
NC_002945.3	Mycobrowser_v4	CDS	4334147	4334737	.	+	0	Mb3941	sigMa		POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMa [FIRST PART]	Mb3941, sigMa, len: 196 aa. Similar to Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(95.8% identity in 168 aa overlap). Possible sigM,alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) PUTATIVE RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa),FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb.	Q7TVD0	No								IPR007627,IPR011991,IPR013249,IPR013324,IPR013325,IPR014284	Q7TVD0	A0A1R3Y5L7									
NC_002945.3	Mycobrowser_v4	CDS	4334626	4334814	.	+	0	Mb3942	sigMb		POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMb [SECOND PART]	Mb3942, sigMb, len: 62 aa. Equivalent to 3' end of Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Possible sigM, alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) PUTATIVE RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa), FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb.		No																			
NC_002945.3	Mycobrowser_v4	CDS	4335688	4336695	.	+	0	Mb3944	trxB2		PROBABLE THIOREDOXIN REDUCTASE TRXB2 (TRXR) (TR)	Mb3944, trxB2, len: 335 aa. Equivalent to Rv3913,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 335 aa overlap). Probable trxB2,thioredoxin reductase (EC 1.6.4.5) (see citation below),equivalent to O30973|TRXB_MYCSM THIOREDOXIN REDUCTASE from Mycobacterium smegmatis (311 aa), FASTA scores: opt: 1575,E(): 1.8e-87, (78.35% identity in 305 aa overlap); and highly similar, but shorter at C-terminus, to P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 1766, E(): 8.7e-99,(83.25% identity in 328 aa overlap). Also highly similar to many e.g. P52215|TRXB_STRCO|SCH24.12 from Streptomyces coelicolor (321 aa), FASTA scores: opt: 1249, E(): 7.2e-68, (60.4% identity in 313 aa overlap); Q9Z8M4|TRXB_CHLPN from Chlamydia pneumoniae (Chlamydophila pneumoniae) (311 aa), FASTA scores: opt: 978, E(): 1.3e-51, (49.85% identity in 307 aa overlap); P09625|TRXB_ECOLI|B0888 from Escherichia coli strain K12 (320 aa), FASTA scores: opt: 948, E(): 8.6e-50, (49.2% identity in 309 aa overlap); etc. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-II. COFACTOR: FAD (BY SIMILARITY).	Q7TVC8	No								IPR000103,IPR001327,IPR005982,IPR008255,IPR013027,IPR023753	Q7TVC8	A0A1R3Y6Y8									
NC_002945.3	Mycobrowser_v4	CDS	4336692	4337042	.	+	0	Mb3945	trxC		THIOREDOXIN TRXC (TRX) (MPT46)	Mb3945, trxC, len: 116 aa. Equivalent to Rv3914,len: 116 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 116 aa overlap). trxC (alternate gene names: trx, trxA *), thioredoxin (EC 1.-.-.-) (see citations below), equivalent to O30974|THIO_MYCSM|TRXA THIOREDOXIN from Mycobacterium smegmatis (112 aa), FASTA scores: opt: 576, E(): 2.1e-32, (80.2% identity in 111 aa overlap); and also equivalent to C-terminal end of P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 628, E(): E(): 2e-35,(82.9% identity in 117 aa overlap). Also highly similar to many e.g. P80579|THIO_ALIAC from Alicyclobacillus acidocaldarius (Bacillus acidocaldarius) (105 aa), FASTA scores: opt: 411, E(): 3e-21, (57.15% identity in 105 aa overlap); P00275|THI1_CORNE from Corynebacterium nephridii (105 aa), FASTA scores: opt: 394, E(): 4.3e-20, (56.7% identity in 97 aa overlap); P00274|THIO_ECOLI|TRXA|TSNC|FIPA|B3781 from Escherichia coli and Salmonella typhimurium strain K12 and LT2 respectively (108 aa), FASTA scores: opt: 364, E(): 4.7e-18, (54.45% identity in 101 aa overlap); etc. Also similar to O53162|TRXB|Rv1471|MTV007.18 THIOREDOXIN from Mycobacterium tuberculosis (123 aa), FASTA scores: E(): 2.3e-15, (41.9% identity in 93 aa overlap). Contains PS00194 Thioredoxin family active site. BELONGS TO THE THIOREDOXIN FAMILY. The product of this CDS is supposed secreted. In this cas, this protein could exert its free radical scavenging activity inside macrophages. (*) Warning: note that Rv1470|MTV007.17 correspond also to trxA.	X2BPP7,P0A617	No	intermediary metabolism and respiration								X2BPP7,P0A617	P0A617				Rv3914		Rv3914			
NC_002945.3	Mycobrowser_v4	CDS	4339417	4340451	.	-	0	Mb3948c	parB		PROBABLE CHROMOSOME PARTITIONING PROTEIN PARB	Mb3948c, parB, len: 344 aa. Equivalent to Rv3917c,len: 344 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 344 aa overlap). Probable parB,chromosome partitioning protein, equivalent to Q50201|PARB_MYCLE|ML2706 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium leprae (333 aa), FASTA scores: opt: 1654, E(): 1.6e-88, (78.6% identity in 332 aa overlap). Also highly similar to to others e.g. Q9S6U1|STH24.09 PUTATIVE PARTITIONING OR SPORULATION PROTEIN from Streptomyces coelicolor (328 aa), FASTA scores: opt: 966, E(): 9.7e-49, (58.55% identity in 287 aa overlap) (no similarity on N-terminus); Q9PB63|PARB_XYLFA|XF2281 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Xylella fastidiosa (310 aa), FASTA scores: opt: 598, E(): 1.8e-27, (38.65% identity in 326 aa overlap); P31857|PARB_PSEPU PROBABLE CHROMOSOME PARTITIONING PROTEIN from Pseudomonas putida (290 aa),FASTA scores: opt: 573, E(): 4.6e-26, (40.35% identity in 322 aa overlap); etc. Contains probable helix-turn-helix motif at aa 179 to 200 (Score 1150, +3.1 0 SD). BELONGS TO THE PARB FAMILY. Note that previously known as parA.	X2BQ08,P0A5R3	No									X2BQ08,P0A5R3	P0A5R3									
NC_002945.3	Mycobrowser_v4	CDS	4340448	4341491	.	-	0	Mb3949c	parA		PROBABLE CHROMOSOME PARTITIONING PROTEIN PARA	Mb3949c, parA, len: 347 aa. Equivalent to Rv3918c,len: 347 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 347 aa overlap). Probable parA,chromosome partitioning protein, highly similar to Q9CCX7|PARA|ML2707 PUTATIVE CELL DIVISION PROTEIN from Mycobacterium leprae (351 aa), FASTA scores: opt: 1679,E(): 2.9e-93, (78.1% identity in 347 aa overlap). Also highly similar to others e.g. Q9RFM1|PARA PARA PROTEIN from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1197, E(): 2e-64, (60.45% identity in 306 aa overlap); Q98DZ3|MLL4479|PARA CHROMOSOME PARTITIONING PROTEIN from Rhizobium loti (Mesorhizobium loti) (266 aa), FASTA scores: opt: 835, E(): 7.2e-43, (50.95% identity in 257 aa overlap); O05189|PARA_CAUCR CHROMOSOME PARTITIONING PROTEIN from Caulobacter crescentus (267 aa), FASTA scores: opt: 813, E(): 1.5e-41, (51.35% identity in 261 aa overlap) (has its N-terminus shorter); etc. Equivalent to AAK48403 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 34 aa. Also similar to other M. tuberculosis proteins: MTCI125.30, FASTA scores: E(): 4.3e-32, (35.2% identity in 327 aa overlap); and MTCY07D11.13, FASTA scores: E(): 3e-30, (39.9% identity in 263 aa overlap). BELONGS TO THE PARA FAMILY. Possible alternative start site at aa 107. Note that previously known as parB.	Q7TVC5	No								IPR002586,IPR027417	Q7TVC5	A0A1R3Y5L9									
NC_002945.3	Mycobrowser_v4	CDS	4341488	4342162	.	-	0	Mb3950c	gid		PROBABLE GLUCOSE-INHIBITED DIVISION PROTEIN B GID	Mb3950c, gid, len: 224 aa. Equivalent to Rv3919c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 224 aa overlap). Probable gid (alternate gene name: gidB), glucose-inhibited division protein B, equivalent, but shorter 20 aa, to Q9L7M3 PUTATIVE GIDB (FRAGMENT) from Mycobacterium paratuberculosis (245 aa), FASTA scores: opt: 1018, E(): 4.8e-57, (73.95% identity in 211 aa overlap); and Q50203|GIDB_MYCLE|ML2708 GLUCOSE INHIBITED DIVISION PROTEIN B from Mycobacterium leprae (245 aa), FASTA scores: opt: 966, E(): 9.1e-54, (68.4% identity in 212 aa overlap). Also highly similar to many e.g. O54571|GIDB_STRCO|STH24.07 from Streptomyces coelicolor (239 aa), FASTA scores: opt: 654, E(): 3.9e-34, (47.95% identity in 221 aa overlap); Q9KNG5|VC2774 from Vibrio cholerae (210 aa), FASTA scores: opt: 300, E(): 6.9e-12,(38.15% identity in 139 aa overlap); P17113|GIDB_ECOLI|B3740|Z5240|ECS4682 from Escherichia coli (several strains) (207 aa), FASTA scores: opt: 287,E(): 4.5e-11, (34.8% identity in 138 aa overlap); etc. Contains PS00539 Pyrokinins signature. BELONGS TO THE GIDB FAMILY.	X2BPQ3,P59964	No									X2BPQ3,P59964	P59964									
NC_002945.3	Mycobrowser_v4	CDS	1244235	1244384	.	-	0	Mb1150c	Mb1150c		HYPOTHETICAL PROTEIN	Mb1150c, -, len: 49 aa. Equivalent to Rv1119c, len: 49 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 49 aa overlap). Hypothetical unknown protein.	Q7U0L9,A0A1R3XXE6	No	conserved hypotheticals			A0A1R3XXE6					Q7U0L9					Rv1119c		Rv1119c			
NC_002945.3	Mycobrowser_v4	tRNA	1177844	1177917	.	+	0	leuX	leuX		tRNA-Leu	leuX, len: 74 nt. Equivalent to leuX, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Leu, anticodon taa.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	1813381	1813454	.	-	0	leuV	leuV		tRNA-Leu	leuV, len: 74 nt. Equivalent to leuV, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Leu, anticodon caa.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	2559359	2559432	.	-	0	metV	metV		tRNA-Met	metV, len: 74 nt. Equivalent to metV, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Met, anticodon cat.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	2597004	2597076	.	-	0	asnT	asnT		tRNA-Asn	asnT, len: 73 nt. Equivalent to asnT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Asn, anticodon gtt.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	2733494	2733567	.	-	0	proU	proU		tRNA-Pro	proU, len: 74 nt. Equivalent to proU, len: 74 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 74 nt overlap). tRNA-Pro; anticodon tgg.		No																			
NC_002945.3	Mycobrowser_v4	CDS	2817888	2818115	.	+	0	Mb2555	vapb17		possible antitoxin vapb17	Mb2555, -, len: 75 aa. Equivalent to Rv2526, len: 75 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in aa overlap). Hypothetical unknown protein.	Q7TYD6,A0A1R3Y1G3	No	virulence, detoxification, adaptation			A0A1R3Y1G3				IPR019239	Q7TYD6					Rv2526		Rv2526			
NC_002945.3	Mycobrowser_v4	CDS	2694029	2694229	.	-	0	Mb2453c	Mb2453c			Mb2453c, -, len: 66 aa. Equivalent to the first part of oxyR' pseudogene (see citation below).		No																			
NC_002945.3	Mycobrowser_v4	CDS	1895926	1896150	.	+	0	Mb1710A	Mb1710A		CONSERVED HYPOTHETICAL PROTEIN	Mb1710A, -, len: 74 aa. Equivalent to Rv1684, len: 74 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 74 aa overlap). Conserved hypothetical protein, similar to P75844|YCAR_ECOLI Protein YCAR from Escherichia coli (60 aa), FASTA scores: opt: 108, E(): 0.00022, (39.0% identity in 59 aa overlap).	Q7TZS8,A0A1R3XZV4	No	conserved hypotheticals			A0A1R3XZV4				IPR005651	Q7TZS8					Rv1684		Rv1684			
NC_002945.3	Mycobrowser_v4	CDS	1116218	1116976	.	+	0	Mb1026	Mb1026		unknown protein	Mb1026, -, len: 252 aa. Equivalent to Rv0999, len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 252 aa overlap). Hypothetical unknown protein.	Q7U0V7,A0A1R3XX26	No	conserved hypotheticals			A0A1R3XX26					Q7U0V7					Rv0999		Rv0999			
NC_002945.3	Mycobrowser_v4	tRNA	1444242	1444314	.	-	0	argV	argV		tRNA-Arg	argV, len: 73 nt. Equivalent to argV, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Arg, anticodon ccg.		No																			
NC_002945.3	Mycobrowser_v4	tRNA	25625	25707	.	+	0	leuT	leuT		tRNA-Leu	leuT, len: 83 nt. Equivalent to leuT, len: 83 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 83 nt overlap). tRNA-Leu, anticodon cag.		No																			
NC_002945.3	Mycobrowser_v4	CDS	162454	162693	.	+	0	Mb0139-3	ephf		possible epoxide hydrolase ephf (epoxide hydratase) (arene-oxide hydratase)	Mb0139-3, -, len: 80 aa. Pseudogene part3 of Rv0134/ephF		No																			
NC_002945.3	Mycobrowser_v4	CDS	3741366	3742256	.	+	0	Mb3408	echA18		probable enoyl-coa hydratase (fragment) echa18.1 (enoyl hydrase) (unsaturated acyl-coa hydratase) (crotonase)	Mb3408, echA18, len: 296 aa. Equivalent to Rv3373 and Rv3374, len: 213 aa and 82 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 213 aa overlap and 100.0% identity in 82 aa overlap). Rv3373: Probable echA18, enoyl-CoA hydratase (EC 4.2.1.17),similar to others e.g. P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 423,E(): 3.4e-20, (37.95% identity in 174 aa overlap); Q9X7Q4|SC5F2A.31c from Streptomyces coelicolor (257 aa),FASTA scores: opt: 399, E(): 1.2e-18, (45.05% identity in 171 aa overlap); BAB52005|MLL5584 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 385,E(): 9.6e-18, (41.95% identity in 174 aa overlap); etc. Also some similarity to 3-HYDROXYBUTYRYL-COA DEHYDRATASES (EC 4.2.1.55) e.g. P52046|CRT_CLOAB from Clostridium acetobutylicum (261 aa), FASTA scores: opt: 414, E(): 1.3e-19, (38.3% identity in 175 aa overlap). And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE (257 aa), FASTA scores: opt: 365, E(): 1.9e-16, (39.1% identity in 174 aa overlap). BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. Note that this homology extends across the stop codon and directly into the next ORF MTV004.29, suggesting a possible readthrough of the TGA stop codon. Rv3374: Probable echA18', enoyl-CoA hydratase C-terminus (EC 4.2.1.17), similar to the C-terminus of several enoyl-CoA hydratases e.g. Q9I5I4|PA0745 from Pseudomonas aeruginosa (272 aa), FASTA scores: opt: 123, E(): 0.13, (34.55% identity in 81 aa overlap); P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 115,E(): 0.45, (32.95% identity in 82 aa overlap); Q9I002|PA2841 from Pseudomonas aeruginosa (263 aa), FASTA scores: opt: 108, E(): 1.4, (30.95% identity in 84 aa overlap); etc. Also some similarity to C-terminus of O29956|AF0285 3-HYDROXYACYL-COA DEHYDROGENASE from Archaeoglobus fulgidus (658 aa), FASTA scores: opt: 116,E(): 0.81, (34.15% identity in 82 aa overlap); and other enzymes. And similar to other hydratases from M. tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-COA HYDRATASE (257 aa), FASTA scores: opt: 111, E(): 0.83, (36.05% identity in 86 aa overlap). This homology extends across the upstream TGA stop codon into the upstream ORF MTV004.28, suggesting possible readthrough of the previous stop codon. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis, a single base transversion (t-g) leads to a single product.	Q7TWL6,A0A1R3Y405	No	lipid metabolism			A0A1R3Y405				IPR001753,IPR018376	Q7TWL6					Rv3373		Rv3373			
NC_002945.3	Mycobrowser_v4	tRNA	4018602	4018674	.	-	0	thrU	thrU		tRNA-Thr	thrU, len: 73 nt. Equivalent to thrU, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Thr, anticodon cgt.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1159365	1159754	.	-	0	Mb1063c	Mb1063c		PROBABLE TRANSPOSASE (FRAGMENT)	Mb1063c, -, len: 129 aa. Equivalent to Rv1034c,len: 129 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 129 aa overlap). Probable IS1560 transposase fragment, similar to part of Rv3387|E1202305|MTV004.45 (225 aa) (65.1% identity in 129 aa overlap).	Q7U0T8,A0A1R3XZA0	No	insertion seqs and phages			A0A1R3XZA0					Q7U0T8					Rv1034c		Rv1034c			
NC_002945.3	Mycobrowser_v4	CDS	843418	843846	.	+	0	Mb0770	vapc31		possible toxin vapc31. contains pin domain.	Mb0770, -, len: 142 aa. Equivalent to Rv0749, len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0749,Rv0277c, Rv2530c, etc.	Q7U1D1,A0A1R3XWA0	No	virulence, detoxification, adaptation			A0A1R3XWA0				IPR002716,IPR006226,IPR022907	Q7U1D1					Rv0749		Rv0749			
NC_002945.3	Mycobrowser_v4	tRNA	2489746	2489817	.	-	0	valV	valV		tRNA-Val	valV, len: 72 nt. Equivalent to valV, len: 72 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 72 nt overlap). tRNA-Val, anticodon tac.		No																			
NC_002945.3	Mycobrowser_v4	CDS	3576849	3577691	.	-	0	Mb3271c	Mb3271c		unknown protein	Mb3271c, -, len: 280 aa. Equivalent to Rv3243c,len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 280 aa overlap). Hypothetical unknown protein.	Q7TWX0,A0A1R3Y3L6	No	conserved hypotheticals			A0A1R3Y3L6				IPR021373	Q7TWX0					Rv3243c		Rv3243c			
NC_002945.3	Mycobrowser_v4	tRNA	11112	11184	.	+	0	alaT	alaT		tRNA-Ala	alaT, len: 73 nt. Equivalent to alaT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Ala, anticodon tgc.		No																			
NC_002945.3	Mycobrowser_v4	CDS	1147008	1147475	.	+	0	Mb1053	Mb1053		conserved protein	Mb1053, -, len: 155 aa. Equivalent to Rv1025, len: 155 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 155 aa overlap). Conserved hypothetical protein, similar to AE001768|AE001768_4 hypothetical protein from Thermotoga maritima (170 aa), FASTA scores: opt: 254, E(): 9.5e-10, (35.7% identity in 143 aa overlap).	Q7U0U4,A0A1R3XZ94	No	conserved hypotheticals			A0A1R3XZ94				IPR007511	Q7U0U4					Rv1025		Rv1025			
NC_002945.3	Mycobrowser_v4	CDS	3083926	3084834	.	-	0	Mb2844c	Mb2844c		HYPOTHETICAL PROTEIN	Mb2844c, -, len: 302 aa. Equivalent to Rv2820c,len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 302 aa overlap). Hypothetical unknown protein.	Q7TXS7,A0A1R3Y2A0	No	conserved hypotheticals			A0A1R3Y2A0				IPR005510	Q7TXS7					Rv2820c		Rv2820c			
NC_002945.3	Mycobrowser_v4	CDS	11874	12311	.	-	0	Mb0008c	Mb0008c		POSSIBLE MEMBRANE PROTEIN	Mb0008c, -, len: 145 aa. Equivalent to Rv0008c,len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 144 aa overlap). Possible membrane protein.	X2BDR6,P59977,P59977	No	cell wall and cell processes			P59977					X2BDR6,P59977					Rv0008c		Rv0008c			
NC_002945.3	Mycobrowser_v4	CDS	1989582	1989797	.	-	0	Mb1795c	Mb1795c		PUTATIVE TRANSPOSASE (FRAGMENT)	Mb1795c, -, len: 71 aa. Equivalent to Rv1765A, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv,(98.6% identity in 71 aa overlap). Putative transposase (fragment), similar to part of many transposase genes including IS6110 e.g. P19774|TRA9_MYCTU PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (278 aa),FASTA scores: opt: 231, E(): 4.7e-11, (45.35% identity in 75 aa overlap).	Q7TZL3,A0A1R3XZA2	No	insertion seqs and phages			A0A1R3XZA2				IPR012337	Q7TZL3					Rv1765A		Rv1765A			
NC_002945.3	Mycobrowser_v4	CDS	2089903	2090538	.	+	0	Mb1882	ureF		Urease accessory protein uref	Mb1882, ureF, len: 211 aa. Equivalent to Rv1851,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). ureF, urease accessory protein. Identical to UREF_MYCTU|P50050 from M. tuberculosis.	X2BJ66,Q7VET6,Q7VET6	No	intermediary metabolism and respiration			Q7VET6					X2BJ66,Q7VET6					Rv1851		Rv1851			
NC_002945.3	Mycobrowser_v4	CDS	396377	397117	.	-	0	Mb0337c	Mb0337c		HYPOTHETICAL PROTEIN	Mb0337c, -, len: 246 aa. Equivalent to Rv0330c,len: 246 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 246 aa overlap). Hypothetical unknown protein.	Q7U289,A0A1R3XV08	No	conserved hypotheticals			A0A1R3XV08				IPR001647,IPR009057,IPR015893	Q7U289					Rv0330c		Rv0330c			
NC_002945.3	Mycobrowser_v4	CDS	1302680	1303120	.	+	0	Mb1204	Mb1204		CONSERVED HYPOTHETICAL PROTEIN	Mb1204, -, len: 146 aa. Equivalent to Rv1171, len: 146 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 146 aa overlap). Conserved hypothetical protein, possibly transmembrane protein. Start has been changed since first submission.	Q7U0H1,A0A1R3XXX5	No	conserved hypotheticals			A0A1R3XXX5					Q7U0H1					Rv1171		Rv1171			
NC_002945.3	Mycobrowser_v4	CDS	3565900	3566541	.	+	0	Mb3263	Mb3263		HYPOTHETICAL ALANINE ARGININE PROLINE RICH PROTEIN	Mb3263, -, len: 213 aa. Equivalent to Rv3235, len: 213 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 213 aa overlap). Hypothetical unknown ala-, arg-, pro-rich protein.	Q7TWX7,A0A1R3Y3I3	No	conserved hypotheticals			A0A1R3Y3I3					Q7TWX7					Rv3235		Rv3235			
NC_002945.3	Mycobrowser_v4	CDS	4274219	4274545	.	+	0	Mb3891	Mb3891		HYPOTHETICAL PROTEIN	Mb3891, -, len: 108 aa. Equivalent to Rv3861, len: 108 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 108 aa overlap). Hypothetical unknown protein.	Q7TVH5,A0A1R3Y5H2	No	conserved hypotheticals			A0A1R3Y5H2					Q7TVH5					Rv3861		Rv3861			
NC_002945.3	Mycobrowser_v4	CDS	33566	33778	.	+	0	Mb0032	Mb0032		possible remnant of a transposase	Mb0032, -, len: 70 aa. Equivalent to Rv0031, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 70 aa overlap). Possible remnant of a transposase, showing partial similarity to mycobacterial transposases in a short overlap, e.g. Rv2791c|MTV002_57 (459 aa), FASTA score: (72.2% identity in 36 aa overlap); Rv2885c, Rv2978c, Rv3827c, etc.	Q7U2Z6,A0A1R3XU29	No	insertion seqs and phages			A0A1R3XU29					Q7U2Z6					Rv0031		Rv0031			
NC_002945.3	Mycobrowser_v4	CDS	3997011	3997172	.	-	0	Mb3643c	Mb3643c		HYPOTHETICAL PROTEIN	Mb3643c, -, len: 53 aa. Equivalent to Rv3613c, len: 53 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 53 aa overlap). Hypothetical unknown protein.	Q7TW36,A0A1R3Y4N2	No	conserved hypotheticals			A0A1R3Y4N2					Q7TW36					Rv3613c		Rv3613c			
NC_002945.3	Mycobrowser_v4	CDS	4220269	4220604	.	+	0	Mb3849	Mb3849		unknown protein	Mb3849, -, len: 111 aa. Equivalent to Rv3819, len: 111 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 111 aa overlap). Hypothetical unknown protein. Contains PS00012 Phosphopantetheine attachment site.	Q7TVL4,A0A1R3Y5D1	No	conserved hypotheticals			A0A1R3Y5D1					Q7TVL4					Rv3819		Rv3819			
NC_002945.3	Mycobrowser_v4	CDS	31498	31803	.	+	0	Mb0029	Mb0029		conserved hypothetical protein	Mb0029, -, len: 101 aa. Equivalent to Rv0028, len: 101 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 101 aa overlap). Hypothetical unknown protein.	X2BDU3,P64670	No	conserved hypotheticals			P64670					X2BDU3					Rv0028		Rv0028			
NC_002945.3	Mycobrowser_v4	CDS	1953102	1953314	.	+	0	Mb1769	vapb34		possible antitoxin vapb34	Mb1769, -, len: 70 aa. Equivalent to Rv1740, len: 70 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 70 aa overlap). Conserved hypothetical protein, highly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96913|Rv0623|MTCY20H10.04 (84 aa), (73.5% identity in 68 aa overlap); P71998|Rv1740 (70 aa), and O07770|Rv0608 (81 aa).	Q7TZN6,A0A1R3XZ61	No	virulence, detoxification, adaptation			A0A1R3XZ61				IPR011660	Q7TZN6					Rv1740		Rv1740			
NC_002945.3	Mycobrowser_v4	CDS	3817453	3818820	.	+	0	Mb3479	mycp4		probable membrane-anchored mycosin mycp4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	Mb3479, -, len: 455 aa. Equivalent to Rv3449, len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 455 aa overlap). Probable secreted serine protease (EC 3.4.21.-). Similar to hypothetical unknowns or proteases from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK48366|MT3998 SUBTILASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (411 aa), FASTA scores: opt: 747, E(): 3.5e-33,(45.65% identity in 416 aa overlap); O05461|Rv3883c|MTCY15F10.29 HYPOTHETICAL PROTEIN (446 aa),FASTA scores: opt: 747, E(): 3.8e-33, (45.45% identity in 451 aa overlap); O53695|Rv0291|MTV035.19 HYPOTHETICAL PROTEIN (461 aa), FASTA scores: opt: 660, E(): 1.9e-28,(44.0% identity in 457 aa overlap); etc. And similar to hypothetical proteases from Mycobacterium leprae e.g. O33076|MLCB628.04|ML0041 HYPOTHETICAL 45.7 KDA PROTEIN (PROBABLE SECRETED PROTEASE) (446 aa), FASTA scores: opt: 683, E(): 1.1e-29, (43.8% identity in 450 aa overlap); Q9CD36|ML2528 PUTATIVE PROTEASE (475 aa), FASTA scores: opt: 608, E(): 1.3e-25, (43.0% identity in 451 aa overlap); Q9CBV3|ML1538 POSSIBLE PROTEASE (567 aa), FASTA scores: opt: 389, E(): 9.7e-14, (33.8% identity in 562 aa overlap); etc. Also some similarity to other proteases from several organisms e.g. O31788|APRX ALKALINE SERINE PROTEASE from Bacillus subtilis (442 aa), FASTA scores: opt: 296, E(): 8.3e-09, (29.4% identity in 313 aa overlap); O86650|SC3C3.17c PUTATIVE SECRETED SERINE PROTEASE from Streptomyces coelicolor (450 aa), FASTA scores: opt: 279, E(): 7e-08, (33.55% identity in 343 aa overlap); Q9KBJ7|APRX|BH193 INTRACELLULAR ALKALINE SERINE PROTEASE from Bacillus halodurans (444 aa), FASTA scores: opt: 257, E(): 1.1e-06, (28.65% identity in 335 aa overlap); O86642|SC3C3.08 SERINE PROTEASE from Streptomyces coelicolor (413 aa), FASTA scores: opt: 243,E(): 5.7e-06, (38.25% identity in 387 aa overlap); etc. Has putative signal peptide at N-terminus and hydrophobic stretch at C-terminus. Contains three signatures typical of subtilase family: aspartic acid active site (PS00136),histidine active site (PS00137), serine active site (PS00138).	Q7TWH3,A0A1R3Y468	No	intermediary metabolism and respiration			A0A1R3Y468				IPR000209,IPR015500,IPR022398,IPR023827,IPR023828,IPR023834	Q7TWH3					Rv3449		Rv3449			
NC_002945.3	Mycobrowser_v4	CDS	3935900	3937957	.	+	0	Mb3584	fdxB		POSSIBLE ELECTRON TRANSFER PROTEIN FDXB	Mb3584, fdxB, len: 685 aa. Equivalent to Rv3554,len: 685 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 685 aa overlap). Possible fdxB,two-domain protein, with ferredoxin reductase electron transfer component in C-terminal part (EC 1.-.-.-) and unknown function in N-terminal part. Indeed, N-terminal end is similar to O85832 HYPOTHETICAL 36.1 KDA PROTEIN from Sphingomonas aromaticivorans strain F199 (catabolic plasmid pNL1) (309 aa), FASTA scores: opt: 615, E(): 2.5e-30, (33.1% identity in 311 aa overlap); and P73428|SLL1468 HYPOTHETICAL 36.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (312 aa), FASTA scores: opt: 317, E(): 4.5e-12, (30.2% identity in 268 aa overlap). And C-terminal end is similar to Q9F9U6|PAAE protein involved in aerobic phenylacetate metabolism from Azoarcus evansii (360 aa), FASTA scores: opt: 935, E(): 7e-50, (43.85% identity in 351 aa overlap); CAC44653|PAAE|SCBAC17A6.08 PUTATIVE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Streptomyces coelicolor (368 aa), FASTA scores: opt: 93, E(): 9.5e-50,(41.95% identity in 372 aa overlap); Q9FA57|PACI FERREDOXIN from Azoarcus evansii (360 aa), FASTA scores: opt: 925, E(): 2.9e-49, (43.3% identity in 351 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Escherichia coli strains K12 and W (356 aa), FASTA scores: opt: 910, E(): 2.4e-48, (43.05% identity in 353 aa overlap); Q9APJ6|PAAE ELECTRON TRANSFER PROTEIN (FRAGMENT) from Hyphomicrobium chloromethanicum (241 aa), FASTA scores: opt: 404, E(): 1.7e-17, (35.45% identity in 234 aa overlap); BAB51608|MLL5100 FERREDOXIN from Rhizobium loti (Mesorhizobium loti) (365 aa), FASTA scores: opt: 316,E(): 5.8e-12, (28.95% identity in 349 aa overlap); etc. C-terminus also similar to P96853|Rv3571|MTCY06G11.18 PUTATIVE ELECTRON TRANSFER PROTEIN from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 450, E(): 3.6e-20, (32.95% identity in 358 aa overlap). Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. BELONGS TO THE 2FE2S PLANT-TYPE FERREDOXIN FAMILY. COFACTOR: BINDS A 2FE-2S CLUSTER (BY SIMILARITY).	Q7TW80,A0A1R3Y4H5	No	intermediary metabolism and respiration			A0A1R3Y4H5				IPR001041,IPR001433,IPR005804,IPR006058,IPR008333,IPR012675,IPR017927,IPR017938	Q7TW80					Rv3554		Rv3554			
NC_002945.3	Mycobrowser_v4	CDS	2523652	2524179	.	+	0	Mb2293	lppN		Probable lipoprotein lppN	Mb2293, lppN, len: 175 aa. Equivalent to Rv2270,len: 175 aa, from Mycobacterium tuberculosis strain H37Rv,(99.4% identity in 175 aa overlap). Probable lppN,lipoprotein; has appropriately positioned prokaryotic membrane lipoprotein attachment site PS00013.	X2BK82,Q7VEM3,Q7VEM3	No	cell wall and cell processes			Q7VEM3					X2BK82,Q7VEM3					Rv2270		Rv2270			
NC_002945.3	Mycobrowser_v4	CDS	98515	99285	.	+	0	Mb0093	Mb0093		POSSIBLE MEMBRANE PROTEIN	Mb0093, -, len: 256 aa. Equivalent to Rv0090, len: 256 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 256 aa overlap). Possible membrane protein.	X2BE01,P64684,P64684	No	cell wall and cell processes			P64684					X2BE01,P64684					Rv0090		Rv0090			
NC_002945.3	Mycobrowser_v4	CDS	1561772	1562104	.	+	0	Mb1425	rpoZ		PROBABLE DNA-DIRECTED RNA POLYMERASE (OMEGA CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE OMEGA SUBUNIT)	Mb1425, rpoZ, len: 110 aa. Equivalent to Rv1390,len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 110 aa overlap). Probable rpoZ,DNA-directed RNA polymerase omega chain (EC 2.7.7.6). BELONGS TO THE RNA POLYMERASE OMEGA CHAIN FAMILY.	X2BHY4,P66722,P66722	No	information pathways			P66722					X2BHY4,P66722					Rv1390		Rv1390			
NC_002945.3	Mycobrowser_v4	CDS	3624111	3624524	.	-	0	Mb3316c	usfY		PUTATIVE PROTEIN USFY	Mb3316c, usfY, len: 137 aa. Equivalent to Rv3288c,len: 137 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 137 aa overlap). usfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins.	P96893,A0A1R3Y5H7	No				A0A1R3Y5H7					P96893										
NC_002945.3	Mycobrowser_v4	CDS	364873	365094	.	+	0	Mb0308	vapb2		possible antitoxin vapb2	Mb0308, -, len: 73 aa. Equivalent to Rv0300, len: 73 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 73 aa overlap). Conserved hypothetical protein, similar to Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa), FASTA scores: opt: 84, E(): 8.3, (39.5% identity in 38 aa overlap).	Q7U2B7,A0A1R3XX31	No	virulence, detoxification, adaptation			A0A1R3XX31				IPR002145,IPR010985	Q7U2B7					Rv0300		Rv0300			
NC_002945.3	Mycobrowser_v4	CDS	365091	365516	.	+	0	Mb0309	vapc2		possible toxin vapc2	Mb0309, -, len: 141 aa. Equivalent to Rv0301, len: 141 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 141 aa overlap). Conserved hypothetical protein, similar to other hypothetical M. tuberculosis proteins e.g. Rv2757c, Rv0229c, Rv2546, etc.	Q7U2B6,A0A1R3XW08	No	virulence, detoxification, adaptation			A0A1R3XW08				IPR002716,IPR022907	Q7U2B6					Rv0301		Rv0301			
NC_002945.3	Mycobrowser_v4	CDS	2213907	2216222	.	-	0	Mb2015c	ctpG		PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE G CTPG	Mb2015c, ctpG, len: 771 aa. Equivalent to Rv1992c,len: 771 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 771 aa overlap). Probable ctpG, metal cation-transporting P-type ATPase G (transmembrane protein) (EC 3.6.3.-), similar to others, especially cadmium-transporting ATPases (EC 3.6.3.3), e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI PROBABLE CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO PROBABLE CADMIUM-TRANSPORTING ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV PUTATIVE CATION TRANSPORTER P-TYPE ATPASE V (770 aa); Rv1469; Rv0092; etc. Contains PS00435 Peroxidases proximal heme-ligand signature and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.	X2BJ77,P63690,P63690	No				P63690					X2BJ77,P63690										
NC_002945.3	Mycobrowser_v4	CDS	2485355	2485531	.	-	0	Mb2256B	vapB16		Possible antitoxin VapB16	Mb2256B, len: 58 aa. Equivalent to Rv2231B len: 58 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 58 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB16,antitoxin,part of toxin-antitoxin (TA) operon with Rv2231A (See Pandey and Gerdes, 2005).	X2BJN5,A0A1R3Y0S0	No	virulence, detoxification, adaptation			A0A1R3Y0S0					X2BJN5					Rv2231B		Rv2231B			
NC_002945.3	Mycobrowser_v4	CDS	885641	886240	.	-	0	Mb0813c	Mb0813c		HYPOTHETICAL PROTEIN	Mb0813c, -, len: 199 aa. Equivalent to Rv0789c,len: 199 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 199 aa overlap). Hypothetical unknown protein.	Q7U198,A0A1R3XYJ2	No	conserved hypotheticals			A0A1R3XYJ2					Q7U198					Rv0789c		Rv0789c			
NC_002945.3	Mycobrowser_v4	CDS	843137	843394	.	+	0	Mb0769	vapb31		possible antitoxin vapb31	Mb0769, -, len: 85 aa. Equivalent to Rv0748, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 85 aa overlap). Conserved hypothetical protein, N-terminus similar to N-terminal region of NP_436939.1|NC_003078 HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (75 aa). Also similar to Mycobacterium tuberculosis proteins Rv2871 CONSERVED HYPOTHETICAL PROTEIN (75 aa); Rv1241, Rv2132, Rv3321c,etc.	Q7U1D2,A0A1R3XWA8	No	virulence, detoxification, adaptation			A0A1R3XWA8				IPR002145	Q7U1D2					Rv0748		Rv0748			
NC_002945.3	Mycobrowser_v4	CDS	419978	420637	.	+	0	Mb0357	Mb0357		HYPOTHETICAL PROTEIN	Mb0357, -, len: 219 aa. Equivalent to Rv0349, len: 219 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 219 aa overlap). Hypothetical unknown protein.	Q7U273,A0A1R3XV35	No	conserved hypotheticals			A0A1R3XV35					Q7U273					Rv0349		Rv0349			
NC_002945.3	Mycobrowser_v4	CDS	148894	149262	.	+	0	Mb0128	Mb0128		unknown protein	Mb0128, -, len: 122 aa. Equivalent to Rv0123, len: 122 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 122 aa overlap). Hypothetical unknown protein.	Q7U2T1,A0A1R3XVK0	No	conserved hypotheticals			A0A1R3XVK0				IPR002145	Q7U2T1					Rv0123		Rv0123			
NC_002945.3	Mycobrowser_v4	CDS	712027	712254	.	+	0	Mb0633A	vapB29		Possible antitoxin VapB29	Mb0633A, len: 75 aa. Equivalent to Rv0616A len: 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible vapB29,antitoxin,part of toxin-antitoxin (TA) operon with Rv0617,see Arcus et al. 2005. Similar to many others in M. tuberculosis e.g. Rv2530A (74 aa) 35.9% identity in 78 aa overlap	X2BFL8,A0A1R3XVV4	No	virulence, detoxification, adaptation			A0A1R3XVV4					X2BFL8					Rv0616A		Rv0616A			
NC_002945.3	Mycobrowser_v4	CDS	712251	712652	.	+	0	Mb0634	vapc29		possible toxin vapc29. contains pin domain.	Mb0634, -, len: 133 aa. Equivalent to Rv0617, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 133 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2494, Rv3320c,Rv0749, Rv0277c, Rv2530c, etc.	Q7U1L9,A0A1R3XY12	No	virulence, detoxification, adaptation			A0A1R3XY12				IPR002716,IPR006226,IPR022907	Q7U1L9					Rv0617		Rv0617			
NC_002945.3	Mycobrowser_v4	CDS	2943318	2944094	.	+	0	Mb2690	ribD		POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE)	Mb2690, ribD, len: 258 aa. Equivalent to Rv2671,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein incuding diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), highly similar to O05684|MLC1351.23|ML1340 POSSIBLE REDUCTASE from Mycobacterium leprae (268 aa), FASTA scores: opt: 1211,E(): 3e-68, (72.9% identity in 251 aa overlap). Also weakly similar to others e.g. Q9HWX2|RIBD|PA4056 RIBOFLAVIN-SPECIFIC DEAMINASE/REDUCTASE from Pseudomonas aeruginosa (373 aa), FASTA scores: opt: 211, E(): 6.3e-06,(30.1% identity in 216 aa overlap); Q9HQA1|RIBG|VNG1256G RIBOFLAVIN-SPECIFIC DEAMINASE from Halobacterium sp. strain NRC-1 (220 aa), FASTA scores: opt: 202, E(): 1.5e-05, (27.0% identity in 174 aa overlap); O28272|RIB7_ARCFU|AF2007 PUTATIVE 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) (EC 1.1.1.193) from Archaeoglobus fulgidus (219 aa), FASTA scores: opt: 209, E(): 5.4e-06, (24.15% identity in 211 aa overlap); P25539|RIBD_ECOLI|RIBG|B0414 from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 185, E(): 0.00026, (26.7% identity in 221 aa overlap); etc. But also similar to several hydrolases e.g. Q9X825|SC9B1.05 PUTATIVE HYDROLASE from Streptomyces coelicolor (265 aa), FASTA scores: opt: 536, E(): 2.9e-26,(44.25% identity in 235 aa overlap); Q9RKM1|SCD17.10 PUTATIVE BIFUNCTIONAL ENZYME DEAMINASE/REDUCTASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 228,E(): 5.6e-07, (33.5% identity in 188 aa overlap); etc. Equivalent to AAK47060 from Mycobacterium tuberculosis strain CDC1551 (239 aa) but longer 19 aa. SUPPOSED BELONG TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY IN THE N-TERMINAL SECTION; and TO THE HTP REDUCTASE FAMILY IN THE C-TERMINAL SECTION.	Q7TY53,A0A1R3Y294	No	intermediary metabolism and respiration			A0A1R3Y294				IPR002734,IPR024072	Q7TY53					Rv2671		Rv2671			
NC_002945.3	Mycobrowser_v4	CDS	1303128	1304054	.	-	0	Mb1205c	PE12		pe family protein pe12	Mb1205c, PE12, len: 308 aa. Equivalent to Rv1172c,len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 308 aa overlap). Member of the Mycobacterium tuberculosis PE family of proteins e.g. P71748|Z81368|MTCY253.25C (361 aa), FASTA scores: opt: 483, E(): 7.8e-22, (46.4% identity in 192 aa overlap).	Q7U0H0,A0A1R3XXK7	No				A0A1R3XXK7				IPR000084	Q7U0H0										
NC_002945.3	Mycobrowser_v4	CDS	719271	719531	.	+	0	Mb0642	vapb5		possible antitoxin vapb5	Mb0642, -, len: 86 aa. Equivalent to Rv0626, len: 86 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 86 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv0596c, Rv3385c,Rv3407,Rv3181c, etc.	Q7U1L3,A0A1R3XVW9	No	virulence, detoxification, adaptation			A0A1R3XVW9				IPR006442	Q7U1L3					Rv0626		Rv0626			
NC_002945.3	Mycobrowser_v4	CDS	719528	719935	.	+	0	Mb0643	vapc5		possible toxin vapc5	Mb0643, -, len: 135 aa. Equivalent to Rv0627, len: 135 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 135 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv0595c and Rv0665.	Q7U1L2,A0A1R3XVX8	No	virulence, detoxification, adaptation			A0A1R3XVX8				IPR002716,IPR022907	Q7U1L2					Rv0627		Rv0627			
NC_002945.3	Mycobrowser_v4	CDS	2090549	2091223	.	+	0	Mb1883	ureG		Urease accessory protein ureG	Mb1883, ureG, len: 224 aa. Equivalent to Rv1852,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). ureG, urease accessory protein. Identical to UREG_MYCTU|P50051 from M. tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UREG FAMILY.	X2BIN9,P0A665,P0A665	No	intermediary metabolism and respiration			P0A665					X2BIN9,P0A665					Rv1852		Rv1852			
NC_002945.3	Mycobrowser_v4	CDS	287669	288106	.	+	0	Mb0246	vapc24		possible toxin vapc24. contains pin domain.	Mb0246, -, len: 145 aa. Equivalent to Rv0240, len: 145 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 145 aa overlap). Conserved hypothetical protein, weak similarity with Rv3697c from Mycobacterium tuberculosis (145 aa), FASTA scores: opt: 145, E(): 7.6e-05, (28.0% identity in 143 aa overlap).	Q7U2H4,A0A1R3XUR6	No	virulence, detoxification, adaptation			A0A1R3XUR6				IPR002716,IPR006226,IPR022907	Q7U2H4					Rv0240		Rv0240			
NC_002945.3	Mycobrowser_v4	tRNA	734760	734832	.	+	0	trpT	trpT		tRNA-Trp	trpT, len: 73 nt. Equivalent to trpT, len: 73 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 73 nt overlap). tRNA-Trp, anticodon cca.		No																			
NC_002945.3	Mycobrowser_v4	CDS	548095	548376	.	-	0	Mb0465c	mazf1		possible toxin mazf1	Mb0465c, -, len: 93 aa. Equivalent to Rv0456A, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Conserved hypothetical protein; N-terminus highly similar to N-terminal part of P71650|Rv2801c|MT2869|MTCY16B7.42 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (118 aa), FASTA scores: opt: 303, E(): 1e-14, (60.44% identity in 91 aa overlap). Also some similarity in part with other hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid maintenance protein from Xylella fastidiosa (108 aa),FASTA scores: opt: 169, E(): 3.9e-05, (50.820% identity in 61 aa overlap).	Q7U1Y5,A0A1R3XVD1	No	virulence, detoxification, adaptation			A0A1R3XVD1				IPR003477,IPR011067	Q7U1Y5					Rv0456A		Rv0456A			
NC_002945.3	Mycobrowser_v4	CDS	548363	548488	.	-	0	Mb0466A	mazE1		Possible antitoxin MazE1	Mb0466A, len: 41 aa. Equivalent to Rv0456B len: 57 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 40 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible mazE1,antitoxin, part of toxin-antitoxin (TA) operon with Rv0456A (See Pandey and Gerdes, 2005; Zhu et al., 2006).	X2BF33,A0A1R3XVD2	No	virulence, detoxification, adaptation			A0A1R3XVD2					X2BF33					Rv0456B		Rv0456B			
NC_002945.3	Mycobrowser_v4	CDS	2351080	2351274	.	-	0	Mb2135c	pup		prokaryotic ubiquitin-like protein pup	Mb2135c, -, len: 64 aa. Equivalent to Rv2111c, len: 64 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 64 aa overlap). Conserved hypothetical protein. Highly similar to a hypothetical protein TR:Q53078 (EMBL:U26422) (64 aa) upstream of Rhodococcus proteasome beta-type subunit 1, FASTA scores; opt: 349,E(): 7.3e-25, 84.4% identity in 64 aa overlap	X2BK62,Q7TZ12,Q7TZ12	No	intermediary metabolism and respiration			Q7TZ12					X2BK62,Q7TZ12					Rv2111c		Rv2111c			
NC_002945.3	Mycobrowser_v4	CDS	1385779	1386210	.	+	0	Mb1274	vapc33		possible toxin vapc33. contains pin domain.	Mb1274, -, len: 143 aa. Equivalent to Rv1242, len: 143 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 143 aa overlap). Conserved hypothetical protein, member of family of 14 hypothetical M. tuberculosis proteins including: Rv2872|Q10800|YS72_MYCTU (147 aa), FASTA scores: opt: 226, E(): 2.7e-09, (32.1% identity in 137 aa overlap); Rv0749, Rv0277c, Rv2530c,etc.	Q7U0B2,A0A1R3XY37	No	virulence, detoxification, adaptation			A0A1R3XY37				IPR002716,IPR006226,IPR022907	Q7U0B2					Rv1242		Rv1242			
NC_002945.3	Mycobrowser_v4	CDS	1405576	1406475	.	+	0	Mb1289	udgb		probable uracil dna glycosylase, udgb	Mb1289, -, len: 299 aa. Equivalent to Rv1259, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 299 aa overlap). Conserved hypothetical protein. Similar to AL109732|SC7H2.04 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 870, E(): 0, (57.1% identity in 231 aa overlap).	X2BHG5,P64786	No	information pathways			P64786					X2BHG5					Rv1259		Rv1259			
NC_002945.3	Mycobrowser_v4	CDS	3673026	3674243	.	+	0	Mb3363	dacB1		probable penicillin-binding protein dacb1 (d-alanyl-d-alanine carboxypeptidase) (dd-peptidase) (dd-carboxypeptidase) (pbp) (dd-transpeptidase) (serine-type d-ala-d-ala carboxypeptidase) (d-amino acid hydrolase)	Mb3363, dacB1, len: 405 aa. Equivalent to Rv3330,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Probable dacB1,D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), equivalent to Mycobacterium leprae proteins Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (411 aa), FASTA scores: opt: 2066, E(): 2.5e-102, (77.15% identity in 416 aa overlap); Q49917|L308_F1_36 (228 aa), FASTA scores: opt: 1241, E(): 7.9e-59, (78.9% identity in 232 aa overlap) (note that this protein corresponds to C-terminal part of the putative protein encoded by Rv3330, aa 174-405); and Q49921|PBPC (182 aa), FASTA scores: opt: 736, E(): 3.7e-32, (73.95% identity in 169 aa overlap) (note that this protein corresponds to N-terminal part of the putative protein encoded by Rv3330, aa 1-158); note L308_F1_36 (228 aa) and PBPC (182 aa) are two consecutive Mycobacterium leprae ORFs . Also similar to others e.g. Q9FC34|SC4G1.16c PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (413 aa),FASTA scores: opt: 572, E(): 3.4e-23, (33.75% identity in 382 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) from Bacillus subtilis (382 aa), FASTA scores: opt: 422,E(): 2.8e-15, (31.3% identity in 249 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN) from Bacillus halodurans (395 aa), FASTA scores: opt: 421, E(): 3.2e-15, (31.95% identity in 241 aa overlap); etc. Also similar to M. tuberculosis Q10828|Rv2911|MTCY274.43 PROBABLE PENICILLIN-BINDING PROTEIN (BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY) (291 aa), FASTA scores: opt: 746, E(): 1.6e-32,(47.0% identity in 266 aa overlap). Has hydrophobic stretches at both N- and C-termini. Certainly membrane-bound protein. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY.	Q7TWP8,A0A1R3Y3V5	No				A0A1R3Y3V5				IPR001967,IPR012338,IPR018044	Q7TWP8										
NC_002945.3	Mycobrowser_v4	CDS	400565	401080	.	-	0	Mb0342c	PE6		pe family protein pe6	Mb0342c, PE6, len: 171 aa. Equivalent to Rv0335c,len: 171 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 171 aa overlap). Member of the Mycobacterium tuberculosis PE family (see first citation below); contains short region of similarity to part of the unique N-terminus of the Mycobacterium tuberculosis PGRS family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 219, E(): 1.1e-08, (51.5% identity in 66 aa overlap).	Q7U284,A0A1R3XV10	No				A0A1R3XV10				IPR000084	Q7U284										
NC_002945.3	Mycobrowser_v4	CDS	2837572	2837817	.	-	0	Mb2580c	vapb20		possible antitoxin vapb20	Mb2580c, -, len: 81 aa. Equivalent to Rv2550c, len: 81 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 81 aa overlap). Hypothetical unknown protein.	Q7TYB5,A0A1R3Y1Y4	No	virulence, detoxification, adaptation			A0A1R3Y1Y4				IPR002145	Q7TYB5					Rv2550c		Rv2550c			
NC_002945.3	Mycobrowser_v4	CDS	2383021	2383236	.	-	0	Mb2166A	parD2		Possible antitoxin ParD2	Mb2166A, len: 71 aa. Equivalent to Rv2142A len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 aa overlap). Transferred from H37Rv annotation using Rapid Annotation Transfer Tool (Nucleic Acids Res. 2011 May; 39(9): e57). Possible parD2,antitoxin, part of toxin-antitoxin (TA) operon with Rv2142c (See Pandey and Gerdes, 2005).	X2BK19,A0A1R3Y2F4	No	virulence, detoxification, adaptation			A0A1R3Y2F4					X2BK19					Rv2142A		Rv2142A			
NC_002945.3	Mycobrowser_v4	CDS	367197	370640	.	-	0	Mb0312c	PPE5		ppe family protein ppe5	Mb0312c, PPE5, len: 1147 aa. Equivalent to 3' end of Rv0304c, len: 2204 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1147 aa overlap). Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Z95324|MTY13E10_16 from M. tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from M. tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0,(42.3% identity in 522 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a shorter CDS (Mb0312c) equivalent to the 3' end of Rv0304c/PPE5.	Q7U2B3,A0A1R3XUY7	No				A0A1R3XUY7				IPR002989	Q7U2B3										
NC_002945.3	Mycobrowser_v4	CDS	1560373	1560945	.	+	0	Mb1423	mihF		PUTATIVE INTEGRATION HOST FACTOR MIHF	Mb1423, mihF, len: 190 aa. Equivalent to Rv1388,len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 190 aa overlap). Putative mihF,integration host factor. Almost identical to, but longer than, P96802|U75344 Mycobacterium smegmatis integration host factor (mIHF) for mycobacteriophage L5 (105 aa),FASTA scores: E(): 0, (96.1% identity in 102 aa overlap).	Q7U052,A0A1R3XYL4	No	information pathways			A0A1R3XYL4					Q7U052					Rv1388		Rv1388			
NC_002945.3	Mycobrowser_v4	CDS	1570419	1570820	.	-	0	Mb1432c	vapc10		possible toxin vapc10	Mb1432c, -, len: 133 aa. Equivalent to Rv1397c,len: 133 aa, from Mycobacterium tuberculosis strain H37Rv,(99.2% identity in 133 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis protein MTCY159.08C|Rv2548 (125 aa), FASTA scores: E(): 2.3e-14,(42.4% identity in 125 aa overlap).	Q7U048,A0A1R3XY88	No	virulence, detoxification, adaptation			A0A1R3XY88				IPR002716,IPR022907	Q7U048					Rv1397c		Rv1397c			
NC_002945.3	Mycobrowser_v4	CDS	1570817	1571074	.	-	0	Mb1433c	vapb10		possible antitoxin vapb10	Mb1433c, -, len: 85 aa. Equivalent to Rv1398c, len: 85 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 85 aa overlap). Conserved hypothetical protein, similar to Mycobacterium tuberculosis proteins Rv2547|MTCY159.09C (85 aa), FASTA scores: E(): 0.0035,(37.1% identity in 62 aa overlap); Rv0581, Rv2871, Rv1241,etc.	X2BHT5,P64836,P64836	No	virulence, detoxification, adaptation			P64836					X2BHT5,P64836					Rv1398c		Rv1398c			
NC_002945.3	Mycobrowser_v4	CDS	2042301	2043149	.	+	0	Mb1839	PPE33b		PPE FAMILY PROTEIN [SECOND PART]	Mb1839, PPE33b, len: 282 aa. Equivalent to 3' end of Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in 471 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t), splits PPE33 into 2 parts, PPE33a and PPE33b, with PPE33a being truncated.		No																			
NC_002945.3	Mycobrowser_v4	CDS	27004	27423	.	-	0	Mb0022c	whiB5		probable transcriptional regulatory protein whib-like whib5	Mb0022c, whiB5, len: 139 aa. Equivalent to Rv0022c,len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 139 aa overlap). Probable whiB5,WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Shows some similarity to O88103|AJ239086|SCO239086_1|WHID|SC6G4.45c|WBLB WHID PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 125, E(): 0.055, (37.1% identity in 97 aa overlap); and slight similarity to G466960|WHIB WHIB PROTEIN (102 aa), FASTA scores: opt: 112, E(): 0.14, (34.3 identity in 67 aa overlap).	Q7U301,A0A1R3XU30	No				A0A1R3XU30				IPR003482	Q7U301										
NC_002945.3	Mycobrowser_v4	CDS	2893191	2893595	.	+	0	Mb2627	vapc40		possible toxin vapc40. contains pin domain.	Mb2627, -, len: 134 aa. Equivalent to Rv2596, len: 134 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 134 aa overlap). Conserved hypothetical protein, only similar to O07780|Rv0598c|MTCY19H5.24 HYPOTHETICAL 14.8 KDA PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA scores: opt: 254, E(): 8.8e-11, (41.55% identity in 130 aa overlap).	Q7TY97,A0A1R3Y3R7	No	virulence, detoxification, adaptation			A0A1R3Y3R7				IPR002716,IPR022907	Q7TY97					Rv2596		Rv2596			
NC_002945.3	Mycobrowser_v4	CDS	2292044	2294668	.	-	0	Mb2077c	ppm1		Polyprenol-monophosphomannose synthase Ppm1	Mb2077c, ppm1, len: 874 aa. Equivalent to Rv2051c,len: 874 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 874 aa overlap). ppm1,Polyprenol-monophosphomannose synthase. Transfers mannose from GDP-Mannose to all endogenous polyprenol-phosphates in Mycobacterium tuberculosis, proven experimentally (A. Baulard, Institut Pasteur de Lille: see citation below). Very similar to polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). Two-domain protein similar to products of two adjacent ORFs in Mycobacterium leprae MLCB2052.01 (644 aa), probable membrane protein and MLCB2052.02 (277 aa). First domain (aa 1 - 590) corresponds to membrane protein with similarity to P23930|LNT_ECOLI apolipoprotein n-acyltransferase (512 aa) while second domain (aa 591 -874) is similar to Schizosaccharomyces pombe dolichol monophosphate mannose synthase (236 aa) and to Mycobacterium tuberculosis Rv0539. FASTA scores: Z 98604|MLCB2052_1 (644 aa) opt: 2725 E(): 0 ; 67.7% identity in 601 aa overlap; and Z98604|MLCB2052_2 (277 aa) opt: 1449 E(): 0; 78.9% identity in 275 aa overlap; and gp|AF0078|AF007873_1 Schizosaccharomyces pombe dolichocholmonophosphate mannose synthase (236 aa) opt: 456 E(): 7.8e-19; 34.5% identity in 223 aa overlap and sp|P23930|LNT_ECOLI APOLIPOPROTEIN N-ACYLTRANSFERASE (512 aa) opt: 330 E(): 1.9e-11; 26.9% identity in 539 aa overlap; and polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). CAC15462.1|AJ294477 putative polyprenol-phosphate-mannose synthase 2 (Ppm2): (55% identity in 533 aa overlap).	Q7VES1,A0A1R3Y276	No				A0A1R3Y276				IPR001173,IPR003010,IPR004563	Q7VES1										
NC_002945.3	Mycobrowser_v4	CDS	1953314	1953562	.	+	0	Mb1770	vapc34		possible toxin vapc34. contains pin domain.	Mb1770, -, len: 82 aa. Equivalent to Rv1741, len: 82 aa, from Mycobacterium tuberculosis strain H37Rv,(98.8% identity in 82 aa overlap). Conserved hypothetical protein, very similar in N-terminus to other M. tuberculosis hypothetical proteins e.g. P96914|Rv0624|MTCY20H10.05 (131 aa), (80.4% identity in 56 aa overlap); P71999|Rv1741 (82 aa) and O07769|Rv0609 (133 aa).	Q7TZN5,A0A1R3Y1B6	No	virulence, detoxification, adaptation			A0A1R3Y1B6					Q7TZN5					Rv1741		Rv1741			
NC_002945.3	Mycobrowser_v4	CDS	2016932	2017231	.	+	0	Mb1816	PE18		pe family protein pe18	Mb1816, PE18, len: 99 aa. Equivalent to Rv1788,len: 99 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 99 aa overlap). Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins, similar to Z93777|MTCI364.07 Mycobacterium tuberculosis cosmid (99 aa), FASTA scores: opt: 414, E(): 3.6e-20, (72.4% identity in 98 aa overlap).	Q7TZJ4,A0A1R3XZB3	No	PE/PPE			A0A1R3XZB3				IPR000084	Q7TZJ4					Rv1788		Rv1788			
NC_002945.3	Mycobrowser_v4	CDS	65542	66684	.	+	0	Mb0063	celA1		POSSIBLE CELLULASE CELA1 (ENDOGLUCANASE) (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL CELLULASE)	Mb0063, celA1, len: 380 aa. Equivalent to Rv0062,len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 380 aa overlap). Possible celA1,cellulase (EC 3.2.1.4), similar to many e.g. AB65568.1|AL136058 putative secreted endoglucanase (cellulase) from Streptomyces coelicolor (332 aa); P07984|GUNA_CELFI ENDOGLUCANASE A PRECURSOR from Cellulomonas fimi (449 aa); GUN1_STRHA|P33682 endoglucanase 1 precursor (cellulase) from STREPTOMYCES HALSTEDII (321 aa), FASTA scores: opt: 702, E(): 1. 2e-27,(38.9% identity in 319 aa overlap); etc. SEEMS TO BELONG TO CELLULASE FAMILY B (FAMILY 6 OF GLYCOSYL HYDROLASES). Note that previously known as celA.	Q7U2Y0,A0A1R3XU64	No				A0A1R3XU64				IPR016288	Q7U2Y0										
NC_002945.3	Mycobrowser_v4	CDS	193816	194301	.	+	0	Mb0169	TB18.5		conserved protein tb18.5	Mb0169, TB18.5, len: 161 aa. Equivalent to Rv0164,len: 161 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 161 aa overlap). TB18.5, conserved hypothetical protein, equivalent to CAB08818.1|Z95398 HYPOTHETICAL PROTEIN from Mycobacterium leprae (156 aa) FASTA scores: opt: 762, E(): 0, (76.3% identity in 152 aa overlap). Some similarity to Rv2185c, Rv0854, Rv0857 from Mycobacterium tuberculosis. Alternative start codon has been suggested. 3' part corrected since first submission (-24 aa).	Q7U2P4,A0A1R3XUP8	No				A0A1R3XUP8				IPR005031,IPR023393	Q7U2P4										
NC_002945.3	Mycobrowser_v4	CDS	3280	4437	.	+	0	Mb0003	recF		DNA REPLICATION AND REPAIR PROTEIN RECF (SINGLE-STRAND DNA BINDING PROTEIN)	Mb0003, recF, len: 385 aa. Equivalent to Rv0003,len: 385 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 385 aa overlap). recF, DNA replication and repair protein (see citations below), equivalent to others Mycobacterial DNA replication and repair proteins e.g. NP_301131.1|NC_002677 from Mycobacterium leprae (385 aa); Q9L7L5|RECF_MYCPA from Mycobacterium avium subsp. paratuberculosis (385 aa); P50916|RECF_MYCSM from Mycobacterium smegmatis (384 aa); etc. Also highly similar to others e.g. P36176|RECF_STRCO DNA REPLICATION AND REPAIR PROTEIN from Streptomyces coelicolor (373 aa); NP_440892.1|NC_000911 from Synechocystis sp. strain PCC 6803 (384 aa); NP_469352.1|NC_003212 from Listeria innocua (370 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00617 RecF protein signature 1, and PS00618 RecF protein signature 2. BELONGS TO THE RECF FAMILY.	X2BDR1,Q7U314,Q7U314	No	information pathways			Q7U314					X2BDR1,Q7U314					Rv0003		Rv0003			
NC_002945.3	Mycobrowser_v4	CDS	137357	137947	.	+	0	Mb0117	gmhA		probable sedoheptulose-7-phosphate isomerase gmha (phosphoheptose isomerase)	Mb0117, gmhA, len: 196 aa. Equivalent to Rv0113,len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 196 aa overlap). Probable gmhA (alternate gene name: lpcA), phosphoheptose isomerase (EC 5.-.-.-), similar to many e.g. AE0005|HPAE000596_11 from Helicobacter pylori (192 aa), FASTA scores: opt: 451, E(): 1.9e-24, (45.1% identity in 162 aa overlap). BELONGS TO THE SIS FAMILY, LPCA SUBFAMILY.	X2BE22,P0A605,P0A605	No	cell wall and cell processes			P0A605					X2BE22,P0A605					Rv0113		Rv0113			
NC_002945.3	Mycobrowser_v4	CDS	331033	331461	.	-	0	Mb0283c	vapc25		possible toxin vapc25. contains pin domain.	Mb0283c, -, len: 142 aa. Equivalent to Rv0277c,len: 142 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 142 aa overlap). Conserved hypothetical protein, highly similar to Rv0749|H70824|2911023|CAA17516.1|AL021958 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (142 aa); and similar to several other hypothetical Mycobacterium tuberculosis proteins: Rv0277c, Rv2530c,etc.	Q7U2D9,A0A1R3XUV0	No	virulence, detoxification, adaptation			A0A1R3XUV0				IPR002716,IPR006226,IPR022907	Q7U2D9					Rv0277c		Rv0277c			
NC_002945.3	Mycobrowser_v4	tRNA	4153262	4153350	.	-	0	serT	serT		tRNA-Ser	serT, len: 89 nt. Equivalent to serT, len: 89 nt,from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 nt overlap). tRNA-Ser, anticodon gct.		No