Refseq_ID Mycobrowser_Version Feature Start Stop Score Strand Frame Locus Name Function Product Comments UniProt_AC Is_Pseudogene Functional_Category Protein Data Bank PFAM UniProt Gene Ontology Enzyme Classification Drug Resistance Mutations InterPro UniProtKB/TrEMBL SWISS-MODEL Orthologues M. marinum Orthologues M. smegmatis Orthologues M. tuberculosis Orthologues M. bovis Orthologues M. lepromatosis Orthologues M. tuberculosis Orthologues M. abscessus Orthologues M. haemophilum Orthologues M. orygis AL450380.2 Mycobrowser_v4 CDS 2119474 2120181 . - ML1751A ML1751A hypothetical protein(pseudogene) ML1751A, len:708. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-96 (See Gomez-Valero et al., 2007) ML1751A, len:708. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-96 (See Gomez-Valero et al., 2007) No conserved hypotheticals AL450380.2 Mycobrowser_v4 CDS 207844 207954 . - 0 ML0146c ML0146c Conserved hypothetical protein (pseudogene) ML0146c, len: 111 bp. Possible pseudogene of M. tuberculosis orthologue Rv0941c (774 bp) (Best blastx scores: 108) Yes conserved hypotheticals Rv0941c Rv0941c AL450380.2 Mycobrowser_v4 CDS 1357447 1359543 . - 0 ML1161c glgE Probable glucanase GlgE (pseudogene) ML1161c, len: 2097 bp. Possible pseudogene of M. tuberculosis orthologue Rv1327c|glgE (2106 bp) (Best blastx scores: 650). Yes intermediary metabolism and respiration Rv1327c Rv1327c AL450380.2 Mycobrowser_v4 CDS 1560503 1561560 . - 0 ML1308c PPE PPE-family protein (pseudogene) ML1308c, len: 1058 bp. Possible pseudogene of M. tuberculosis orthologue PPE37|Rv2123 (1422 bp) (Best blastx scores: 241). Yes PE/PPE Rv2123 Rv2123 AL450380.2 Mycobrowser_v4 CDS 1571682 1572943 . + 0 ML1319 ML1319 Possible oxidoreductase (pseudogene) ML1319, len: 1262 bp. Possible pseudogene similar to M. tuberculosis Rv3727 (1809 bp) (Best blastx scores: 380). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1010013 1011177 . + 0 ML0850 ltp1 Probable lipid-transfer protein Ltp1 (pseudogene) ML0850, len: 1165 bp. Possible pseudogene of M. tuberculosis orthologue ltp1|Rv2790c (1206 bp) (Best blastx scores: 347). Yes cell wall and cell processes Rv2790c Rv2790c AL450380.2 Mycobrowser_v4 CDS 1360095 1362293 . + 0 ML1162 glgP Probable glycogen phosphorylase GlgP (pseudogene) ML1162, len: 2199 bp. Possible pseudogene of M. tuberculosis orthologue glgP|Rv1328 (2592 bp) (Best blastx scores: 579). Yes intermediary metabolism and respiration Rv1328 Rv1328 AL450380.2 Mycobrowser_v4 CDS 3184054 3185245 . + 0 ML2660 fusA2 Probable elongation factor G FusA2 (pseudogene) ML2660, len: 1192 bp. Possible pseudogene of M. tuberculosis orthologue fusA2|Rv0120c (2145 bp) (Best blastx scores: 254). Yes information pathways Rv0120c Rv0120c AL450380.2 Mycobrowser_v4 CDS 53719 54695 . + 0 ML0043 espB Conserved hypothetical ala-, gly-rich protein (pseudogene) ML0043, len: 977 bp. Possible pseudogene of M. tuberculosis orthologue Rv3881c (1380 bp) (Best blastx scores: 163) Yes cell wall and cell processes Rv3881c Rv3881c AL450380.2 Mycobrowser_v4 CDS 71142 72064 . - 0 ML0057c espG1 ESX-1 SECRETION-ASSOCIATED PROTEIN ESPG1 (PSEUDOGENE) ML0057c, len: 923 bp. Possible pseudogene of M. tuberculosis orthologue Rv3866 (849 bp) (Best blastx scores: 427) Yes cell wall and cell processes Rv3866 Rv3866 AL450380.2 Mycobrowser_v4 CDS 57567 57922 . - 0 ML0046c espJ ESX-1 SECRETION-ASSOCIATED PROTEIN ESPJ(PSEUDOGENE) ML0046c, len: 356 bp. Possible pseudogene of M. tuberculosis orthologue Rv3878 (840 bp) (Best blastx scores: 118) Yes cell wall and cell processes Rv3878 Rv3878 AL450380.2 Mycobrowser_v4 CDS 542562 543750 . + 0 ML0443 pdhC Probable dihydrolipoamide S-acetyltransferase E2 component PdhC (pseudogene) ML0443, len: 1189 bp. Possible pseudogene of M. tuberculosis orthologue pdhC|Rv2495c (1182 bp) (Best blastx scores: 324) Yes intermediary metabolism and respiration Rv2495c Rv2495c AL450380.2 Mycobrowser_v4 CDS 500827 501748 . - 0 ML0403c iunH Probable nucleoside hydrolase IunH (pseudogene) ML0403c, len: 922 bp. Possible pseudogene of M. tuberculosis orthologue iunH|Rv3393 (927 bp) (Best blastx scores: 213) Yes intermediary metabolism and respiration Rv3393 Rv3393 AL450380.2 Mycobrowser_v4 CDS 501851 502404 . + 0 ML0404 cmaA1 Cyclopropane mycolic acid synthase 1 CmaA1 (pseudogene) ML0404, len: 554 bp. Possible pseudogene of M. tuberculosis orthologue cmaA1|Rv3392c (864 bp) (Best blastx scores: 278) Yes lipid metabolism Rv3392c Rv3392c AL450380.2 Mycobrowser_v4 CDS 510370 510982 . - 0 ML0412c lpqD Probable conserved lipoprotein LpqD (pseudogene) ML0412c, len: 613 bp. Possible pseudogene of M. tuberculosis orthologue lpqD|Rv3390 (711 bp) (Best blastx scores: 254) Yes cell wall and cell processes Rv3390 Rv3390 AL450380.2 Mycobrowser_v4 CDS 513500 514619 . - 0 ML0415c ML0415c Conserved hypothetical protein (pseudogene) ML0415c, len: 1120 bp. Possible pseudogene of M. tuberculosis orthologue Rv3371 (1341 bp) (Best blastx scores: 169) Yes lipid metabolism Rv3371 Rv3371 AL450380.2 Mycobrowser_v4 CDS 514920 517124 . + 0 ML0416 dnaE2 DNA polymerase III [alpha chain] DnaE2 (pseudogene) ML0416, len: 2205 bp. Possible pseudogene of M. tuberculosis orthologue dnaE2|Rv3370c (3240 bp) (Best blastx scores: 538) Yes information pathways Rv3370c Rv3370c AL450380.2 Mycobrowser_v4 CDS 517300 517584 . - 0 ML0417c ML0417c Conserved hypothetical protein (pseudogene) ML0417c, len: 285 bp. Possible pseudogene of M. tuberculosis orthologue Rv3369 (435 bp) (Best blastx scores: 151) Yes conserved hypotheticals Rv3369 Rv3369 AL450380.2 Mycobrowser_v4 CDS 546028 546565 . - 0 ML0445c ML0445c REP-family protein (pseudogene) ML0445c, len: 538 bp. Possible pseudogene similar to M. tuberculosis REP-family protein, similar to Rv1128c, Rv1702, Rv3466 etc (Best blastx scores: 218). Yes unknown AL450380.2 Mycobrowser_v4 CDS 546689 547133 . - 0 ML0446c echA14 Probable enoyl-CoA hydratase EchA14 (pseudogene) ML0446c, len: 445 bp. Possible pseudogene similar to M. tuberculosis orthologue echA14|Rv2486 (771 bp) (Best blastx scores: 194) Yes lipid metabolism Rv2486 Rv2486 AL450380.2 Mycobrowser_v4 CDS 519276 521680 . + 0 ML0420 ML0420 Conserved hypothetical protein (pseudogene) ML0420, 2405 bp. Possible pseudogene of M. tuberculosis orthologue Rv3365c (2631 bp) (Best blastx scores: 540) Yes conserved hypotheticals Rv3365c Rv3365c AL450380.2 Mycobrowser_v4 CDS 521735 522127 . + 0 ML0421 ML0421 Conserved hypothetical protein (pseudogene) ML0421, len: 393 bp. Possible pseudogene of M. tuberculosis orthologue Rv3364c (393 bp) (Best blastx scores: 181) Yes conserved hypotheticals Rv3364c Rv3364c AL450380.2 Mycobrowser_v4 CDS 522248 522814 . + 0 ML0422 ML0422 Probable ATP/GTP-binding protein (pseudogene) ML0422, len: 567 bp. Possible pseudogene of M. tuberculosis orthologue Rv3362c (582 bp) (Best blastx scores: 425) Yes conserved hypotheticals Rv3362c Rv3362c AL450380.2 Mycobrowser_v4 CDS 522865 523112 . + 0 ML0423 ML0423 Conserved hypothetical protein (pseudogene) ML0423, len: 248 bp. Possible pseudogene of M. tuberculosis orthologue Rv3361c (552 bp) (Best blastx scores: 162) Yes conserved hypotheticals Rv3361c Rv3361c AL450380.2 Mycobrowser_v4 CDS 527083 528558 . + 0 ML0428 ML0428 Conserved hypothetical protein (pseudogene) ML0428, len: 1476 bp. Possible pseudogene of M. tuberculosis orthologue Rv2510c (1602 bp) (Best blastx scores: 399) Yes conserved hypotheticals Rv2510c Rv2510c AL450380.2 Mycobrowser_v4 CDS 1352048 1352331 . + 0 ML1156 ML1156 Conserved hypothetical protein (pseudogene) ML1156, len: 284 bp. Possible pseudogene of M. tuberculosis orthologue Rv1322 (297 bp) (Best blastx scores: 222). Yes conserved hypotheticals Rv1322 Rv1322 AL450380.2 Mycobrowser_v4 CDS 531815 532465 . - 0 ML0432c ML0432c Probable transcriptional regulatory protein (TetR-family) (pseudogene) ML0432c, len: 651 bp. Possible pseudogene of M. tuberculosis orthologue Rv2506 (648 bp) (Best blastx scores: 173) Yes regulatory proteins Rv2506 Rv2506 AL450380.2 Mycobrowser_v4 CDS 532615 533913 . + 0 ML0433 fadD35 Probable fatty-acid-CoA synthase FadD35 (pseudogene) ML0433, len: 1299 bp. Possible pseudogene of M. tuberculosis orthologue fadD35|Rv2505c (1644 bp) (Best blastx scores: 403) Yes lipid metabolism Rv2505c Rv2505c AL450380.2 Mycobrowser_v4 CDS 534034 534711 . + 0 ML0434 scoA Probable succinyl-CoA:3-ketoacid-Coenzyme A transferase [alpha subunit] ScoA (pseudogene) ML0434, len: 678 bp. Possible pseudogene of M. tuberculosis orthologue scoA|Rv2504c (747 bp) (Best blastx scores: 439) Yes lipid metabolism Rv2504c Rv2504c AL450380.2 Mycobrowser_v4 CDS 1363264 1364088 . - 0 ML1163c ML1163c Probable conserved transmembrane protein (pseudogene) ML1163c, len: 825 bp. Possible pseudogene similar to M. tuberculosis membrane proteins e.g. Rv3239c and Rv3728 (Best blastx scores: 223). Yes unknown AL450380.2 Mycobrowser_v4 CDS 534770 535415 . + 0 ML0435 scoB Probable succinyl-CoA:3-ketoacid-CoA transferase [beta subunit] ScoB (pseudogene) ML0435, len: 646 bp. Possible pseudogene of M. tuberculosis orthologue scoB|Rv2503c (657 bp) (Best blastx scores: 465) Yes lipid metabolism Rv2503c Rv2503c AL450380.2 Mycobrowser_v4 CDS 535415 537001 . + 0 ML0436 accD1 Probable acetyl/propionyl-CoA carboxylase, [beta subunit] AccD1 (pseudogene) ML0436, len: 1587 bp. Possible pseudogene of M. tuberculosis orthologue accD1|Rv2502c (1590 bp) (Best blastx scores: 396) Yes lipid metabolism Rv2502c Rv2502c AL450380.2 Mycobrowser_v4 CDS 538599 539716 . + 0 ML0438 fadE19 Possible acyl-CoA dehydrogenase FadE19 (MmgC) (pseudogene) ML0438, len: 1118 bp. Possible pseudogene of M. tuberculosis orthologue fadE19|Rv2500c (1185 bp) (Best blastx scores: 346) Yes lipid metabolism Rv2500c Rv2500c AL450380.2 Mycobrowser_v4 CDS 1364069 1364509 . - 0 ML1164c ML1164c Conserved hypothetical protein (pseudogene) ML1164c, len: 441 bp. Possible pseudogene of M. tuberculosis orthologue Rv1330c (1347 bp) (Best blastx scores: 280). Yes intermediary metabolism and respiration Rv1330c Rv1330c AL450380.2 Mycobrowser_v4 CDS 549367 550150 . - 0 ML0449c tesB2 Probable acyl-CoA thioesterase II TesB2 (TEII) (pseudogene) ML0449c, len: 784 bp. Possible pseudogene of M. tuberculosis orthologue tesB2|Rv2605c (846 bp) (Best blastx scores: 159) Yes lipid metabolism Rv2605c Rv2605c AL450380.2 Mycobrowser_v4 CDS 824242 825377 . - 0 ML0688c nagA Probable N-acetylglucosamine-6-Phosphate deacetylase NagA (pseudogene) ML0688c, len: 1136 bp. Possible pseudogene of M. tuberculosis orthologue nagA|Rv3332 (1152 bp) (Best blastx scores: 253). Yes cell wall and cell processes Rv3332 Rv3332 AL450380.2 Mycobrowser_v4 CDS 1708604 1709271 . - 0 ML1421c ML1421c Conserved hypothetical protein (pseudogene) ML1421c, len: 668 bp. Possible pseudogene of M. tuberculosis orthologue Rv2005c (888 bp) (Best blastx scores: 239). Yes virulence, detoxification, adaptation Rv2005c Rv2005c AL450380.2 Mycobrowser_v4 CDS 547993 548265 . + 0 ML0448 ML0448 Hypothetical protein ML0448, len: 90 aa. Hypothetical Unknown protein. Previously sequenced as O07143|Z96801 (90 aa), Fasta scores: E(): 0, (100.0% identity in 90 aa overlap). Q7AQJ2 No unknown Q7AQJ2 AL450380.2 Mycobrowser_v4 CDS 1367414 1368400 . + 0 ML1170 cysM Probable cysteine synthase B CysM (pseudogene) ML1170, len: 987 bp. Possible pseudogene of M. tuberculosis orthologue cysM|Rv1336 (Rv1336) (Best blastx scores: 302). Yes intermediary metabolism and respiration Rv1336 Rv1336 AL450380.2 Mycobrowser_v4 CDS 557909 558314 . - 0 ML0457c ML0457c Conserved hypothetical protein (pseudogene) ML0457c, len: 406 bp. Possible pseudogene similar to M. tuberculosis Rv0356c (645 bp) (Best blastx scores: 97), also similar to ML0279c a possible orthologue of M. tuberculosis Rv0356c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 559294 559667 . + 0 ML0459 ML0459 Conserved hypothetical protein (pseudogene) ML0459, len: 374 bp. Possible pseudogene of M. tuberculosis orthologue Rv2616 (501 bp) (Best blastx scores: 154) Yes conserved hypotheticals Rv2616 Rv2616 AL450380.2 Mycobrowser_v4 CDS 559772 559990 . - 0 ML0460c ML0460c Probable transmembrane protein (pseudogene) ML0460c, len: 219 bp. Possible pseudogene of M. tuberculosis orthologue Rv2617c (441 bp) (Best blastx scores: 163) Yes cell wall and cell processes Rv2617c Rv2617c AL450380.2 Mycobrowser_v4 CDS 560206 560552 . + 0 ML0461 ML0461 Conserved hypothetical protein (pseudogene) ML0461, len: 347 bp. Possible pseudogene of M. tuberculosis orthologue Rv2618 (678 bp) (Best blastx scores: 222) Yes conserved hypotheticals Rv2618 Rv2618 AL450380.2 Mycobrowser_v4 CDS 561079 561564 . - 0 ML0462c ML0462c Conserved hypothetical protein (pseudogene) ML0462c, len: 486 bp. Possible pseudogene similar to M. tuberculosis Rv0021c (969 bp) (Best blastx scores: 169) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1256589 1257691 . ML1092A ML1092A putative malate oxidoreductase(pseudogene) "Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-74 (See Gomez-Valero et al., 2007)" Yes conserved hypotheticals AL450380.2 Mycobrowser_v4 CDS 2728984 2729070 . ML2304A ML2304A hypothetical protein(pseudogene) ML2304A, len:86. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-11 (See Gomez-Valero et al., 2007) Yes conserved hypotheticals AL450380.2 Mycobrowser_v4 CDS 3147153 3147689 . ML2630A ML2630A hypothetical protein(pseudogene) ML2630A, len:528. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-19 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 951152 951440 . ML0801A ML0801A Possible anti-sigma factor (pseudogene) ML0801A, len: 199 bp. Possible pseudogene of M. tuberculosis orthologue Rv3221A (306 bp) (Best blastx scores: 176). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2977471 2978043 . ML2499A lpqJ Probable lipoprotein LpqJ ML2499A, len: 190 aa. Hypothetical protein Similar to O06295|Rv0344c Probable lpqJ Lipoprotein from M. tuberculosis (186 aa), fasta scores: E(): 4e-38 (67.598% identity in 179 aa overlap). Has an appropriately positioned prokaryotic lipoprotein signature (PS00013). No cell wall and cell processes AL450380.2 Mycobrowser_v4 CDS 561580 561829 . - 0 ML0463c ML0463c Conserved hypothetical protein (pseudogene) ML0463c, len: 250 bp. Possible pseudogene similar to M. tuberculosis Rv2619c (354 bp) (Best blastx scores: 147) Yes conserved hypotheticals Rv2619c Rv2619c AL450380.2 Mycobrowser_v4 CDS 1776100 1776708 . - 0 ML1474c mobA Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA (pseudogene) ML1474c, len: 609 bp. Possible pseudogene of M. tuberculosis orthologue Rv2453c|mobA (606 bp) (Best blastx scores: 269). Yes intermediary metabolism and respiration Rv2453c Rv2453c AL450380.2 Mycobrowser_v4 CDS 206601 206740 . - 0 ML0145c ML0145c Possible transposase remnant (pseudogene) ML0145c, len: 140 bp. Possible transposase remnant, some similarity to Q9RBZ3 transposase from Pseudomonas syringae (1071 bp), (blastx scores: 51) and to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 41). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 39947 40211 . + 0 ML0033 ML0033 Conserved hypothetical protein (pseudogene) ML0033, len: 265 bp. Possible pseudogene similar to M. tuberculosis ortholog Rv3906c (507 bp) (Best blastx scores: 95) Yes conserved hypotheticals Rv3906c Rv3906c AL450380.2 Mycobrowser_v4 CDS 40825 41032 . + 0 ML0034 esxC Putative ESAT-6 like protein esxC (pseudogene) ML0034, len: 208 bp. Possible pseudogene of M. tuberculosis orthologue Rv3890c (285 bp) (Best blastx scores: 54) Yes cell wall and cell processes Rv3890c Rv3890c AL450380.2 Mycobrowser_v4 CDS 42222 43083 . + 0 ML0035 ML0035 Probable conserved membrane protein (pseudogene) ML0035, len: 862 bp. Possible pseudogene of M. tuberculosis orthologue Rv3888c (1023 bp) (Best blastx scores: 182) Yes cell wall and cell processes Rv3888c Rv3888c AL450380.2 Mycobrowser_v4 CDS 44077 45332 . + 0 ML0037 mycP2 Probable alanine and proline rich membrane-anchored mycosin mycP2 (pseudogene) ML0037, len: 1256 bp. Possible pseudogene of M. tuberculosis orthologue Rv3886c|mycP2 (1650 bp) (Best blastx scores: 160) Yes intermediary metabolism and respiration Rv3886c Rv3886c AL450380.2 Mycobrowser_v4 CDS 49689 49946 . - 0 ML0040c ML0040c Probable transposase remnant (pseudogene) ML0040c, len: 258 bp. Possible transposase remnant, similar to the N-terminus of Rv2424c|P71924 probable transposase for IS1558 from M. tuberculosis (999 bp) Yes unknown AL450380.2 Mycobrowser_v4 CDS 235667 235822 . + 0 ML0170 ML0170 Conserved hypothetical protein (pseudogene) ML0170, len: 156 bp. Possible pseudogene of M. tuberculosis orthologue Rv0965c (420 bp) (Best blastx scores: 115) Yes conserved hypotheticals Rv0965c Rv0965c AL450380.2 Mycobrowser_v4 CDS 711833 712695 . + 0 ML0586 ML0586 Conserved hypothetical protein (pseudogene) ML0586, len: 863 bp. Possible pseudogene of M. tuberculosis orthologue Rv1455 (864 bp) (Best blastx scores: 414) Yes conserved hypotheticals Rv1455 Rv1455 AL450380.2 Mycobrowser_v4 CDS 28954 29265 . - 0 ML0023c ML0023c Hypothetical protein ML0023c, len: 103 aa. Hypothetical unknown protein. Improbable CDS, possibly the remains of a disrupted gene. Q9CDE3 No unknown Q9CDE3 AL450380.2 Mycobrowser_v4 CDS 29775 30026 . + 0 ML0024 ML0024 Hypothetical protein ML0024, len: 83 aa. Hypothetical unknown protein. Q9CDE2 No unknown Q9CDE2 AL450380.2 Mycobrowser_v4 CDS 30293 30583 . - 0 ML0025c ML0025c Hypothetical protein ML0025c, len: 96 aa. Hypothetical unknown protein. Q9CDE1 No unknown Q9CDE1 AL450380.2 Mycobrowser_v4 CDS 1508865 1509125 . - 0 ML1265c ML1265c Possible conserved transmembrane protein (pseudogene) ML1265c, len: 261 bp. Possible pseudogene similar to M. tuberculosis Rv2345 (1983 bp) (Best blastx scores: 100) and also similar to Rv2689 and Rv1376. Also similar to ML0830c a possible pseudogene similar to M. tuberculosis Rv2345. Yes unknown AL450380.2 Mycobrowser_v4 CDS 574033 574275 . + 0 ML0472 ML0472 Hypothetical protein ML0472, len: 80 aa. Hypothetical unknown protein. Improbable CDS suggested by GC frameplot and codon usage plots. Possibly the remains of a disrupted gene. Q9CCT7 No unknown Q9CCT7 AL450380.2 Mycobrowser_v4 CDS 608648 609030 . + 0 ML0502 ML0502 Conserved hypothetical protein (pseudogene) ML0502, len: 383 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins e.g Rv1558, Rv3547 and Rv3178 (Best blastx scores: 72) Yes unknown AL450380.2 Mycobrowser_v4 CDS 609985 610359 . + 0 ML0503 PPE PPE-family protein (pseudogene) ML0503, len: 375 bp. Possible pseudogene similar to several M. tuberculosis PPE genes e.g. PPE41|Rv2430c, PPE22|Rv1705c, PPE26|Rv1789, PPE15|Rv1039c and PPE43|Rv2768c (Best blastx scores: 98) Yes unknown AL450380.2 Mycobrowser_v4 CDS 601153 601598 . + 0 ML0495 PE_PGRS2 PE_PGRS-family protein (pseudogene) ML0495, len: 446 bp. Possible pseudogene similar to M. tuberculosis PE_PGRS genes e.g PE_PGRS58, PE_PGRS26, PE_PGRS27 etc (Best blastx scores: 176). Yes unknown AL450380.2 Mycobrowser_v4 CDS 615181 617504 . + 0 ML0507 ML0507 Conserved hypothetical alanine and leucine rich protein (pseudogene) ML0507, len: 2324 bp. Possible pseudogene similar to M. tuberculosis Rv2567 (2655 bp) (Best blastx scores: 542) and similar to M. leprae ML2679 a possible orthologue of M. tuberculosis Rv2567. Yes unknown AL450380.2 Mycobrowser_v4 CDS 618436 619451 . + 0 ML0509 ML0509 Conserved hypothetical protein (pseudogene) ML0509, len: 1016 bp. Possible pseudogene of M. tuberculosis orthologue Rv2568c (1026 bp) (Best blastx scores: 271) Yes conserved hypotheticals Rv2568c Rv2568c AL450380.2 Mycobrowser_v4 CDS 690749 690991 . + 0 ML0568A ML0568A Conserved hypothetical protein ML0568A, len: 80 aa. Conserved hypothetical protein, identical to the other hypothetical CDS ML0599B and ML1292c from M. leprae. No conserved hypotheticals AL450380.2 Mycobrowser_v4 CDS 754966 755391 . - 0 ML0622c ML0622c Probable transposase fusion protein (pseudogene) ML0622c, len: 426 bp. Possible pseudogene similar to M. tuberculosis Rv3327 (1713 bp) (Best blastx scores: 106). Yes unknown AL450380.2 Mycobrowser_v4 CDS 755667 755985 . - 0 ML0623c ML0623c Conserved hypothetical protein (pseudogene) ML0623c, len: 319 bp. Possible pseudogene of M. tuberculosis orthologue Rv2375 (318 bp) (Best blastx scores: 230). Yes conserved hypotheticals Rv2375 Rv2375 AL450380.2 Mycobrowser_v4 CDS 754091 754774 . - 0 ML0621c ML0621c Possible alternative RNA polymerase sigma factor (pseudogene) ML0621c, len: 684 bp. Possible pseudogene similar to M. tuberculosis sigI gene (Best blastx scores: 110) Yes unknown AL450380.2 Mycobrowser_v4 CDS 751914 752429 . - 0 ML0619c ML0619c Conserved hypothetical protein (pseudogene) ML0619c, len: 516 bp. Possible pseudogene of M. tuberculosis orthologue Rv2387 (1254 bp) (Best blastx scores: 213) Yes conserved hypotheticals Rv2387 Rv2387 AL450380.2 Mycobrowser_v4 CDS 761728 763013 . + 0 ML0629 ML0629 Probable conserved transmembrane protein (pseudogene) ML0629, len: 1286 bp. Possible pseudogene of M. tuberculosis orthologue Rv2366c (1308 bp) (Best blastx scores: 651). Yes cell wall and cell processes Rv2366c Rv2366c AL450380.2 Mycobrowser_v4 CDS 791658 792393 . + 0 ML0654 moxR3 Probable methanol dehydrogenase transcriptional regulatory protein MoxR3 (pseudogene) ML0654, len: 736 bp. Possible pseudogene of M. tuberculosis orthologue moxR3|Rv3164c (963 bp) (Best blastx scores: 249). Yes regulatory proteins Rv3164c Rv3164c AL450380.2 Mycobrowser_v4 CDS 1776717 1777664 . - 0 ML1475c ML1475c Probable oxidoreductase, beta subunit (pseudogene) ML1475c, len: 948 bp. Possible pseudogene of M. tuberculosis orthologue Rv2454c (1122 bp) (Best blastx scores: 505). Yes intermediary metabolism and respiration Rv2454c Rv2454c AL450380.2 Mycobrowser_v4 CDS 800706 801967 . + 0 ML0665 agpS Possible alkyl-dihydroxyacetonephosphate synthase AgpS (pseudogene) ML0665, len: 1262 bp. Possible pseudogene of M. tuberculosis orthologue Rv3107c|agpS (1584 bp) (Best blastx scores: 234). Yes lipid metabolism Rv3107c Rv3107c AL450380.2 Mycobrowser_v4 CDS 804681 805480 . + 0 ML0668 ML0668 Possible conserved transmembrane protein (pseudogene) ML0668, len: 800 bp. Possible pseudogene of M. tuberculosis orthologue Rv3104c (927 bp) (Best blastx scores: 303). Yes cell wall and cell processes Rv3104c Rv3104c AL450380.2 Mycobrowser_v4 CDS 800117 800380 . + 0 ML0664 ML0664 Hypothetical protein ML0664, len: 87 aa. Hypothetical protein. Q9CCM5 No unknown Q9CCM5 AL450380.2 Mycobrowser_v4 CDS 1807556 1808257 . - 0 ML1499c narI Probable respiratory nitrate reductase (gamma chain) NarI (pseudogene) ML1499c, len: 702 bp. Possible pseudogene of M. tuberculosis orthologue narI|Rv1164 (741 bp) (Best blastx scores: 222). Yes intermediary metabolism and respiration Rv1164 Rv1164 AL450380.2 Mycobrowser_v4 CDS 2772791 2773834 . - 0 ML2338c ML2338c Probable lipase (pseudogene) ML2338c, len: 1044 bp. Possible pseudogene similar to M. tuberculosis lipD|Rv1923 (1341 bp) (Best blastx scores: 246). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1818586 1819133 . - 0 ML1507c ML1507c Conserved hypothetical protein (pseudogene) ML1507c, len: 548 bp. Possible pseudogene of M. tuberculosis orthologue Rv1156 (588 bp) (Best blastx scores: 351). Yes conserved hypotheticals Rv1156 Rv1156 AL450380.2 Mycobrowser_v4 CDS 1819949 1820612 . + 0 ML1509 ML1509 Hypothetical protein (pseudogene) ML1509, len: 664 bp. Possible pseudogene of M. tuberculosis orthologue Rv1154c (642 bp) (Best blastx scores: 204). Yes conserved hypotheticals Rv1154c Rv1154c AL450380.2 Mycobrowser_v4 CDS 799662 799976 . + 0 ML0663 ML0663 Conserved hypothetical protein ML0663, len: 104 aa. Conserved hypothetical protein, highly similar to Q8VJ68|MT3222 Hypothetical protein from M. tuberculosis strain CDC1551 (110 aa), fasta scores: opt: 483, E(): 1e-27, (69.307% identity in 101 aa overlap). Previously sequenced as O32888|Z98271 (104 aa), Fasta scores: E(): 0, (99.0% identity in 104 aa overlap). Q7AQG6 No conserved hypotheticals Q7AQG6 AL450380.2 Mycobrowser_v4 CDS 808149 808842 . + 0 ML0672 ML0672 Conserved hypothetical protein (pseudogene) ML0672, len: 694 bp. Possible pseudogene of M. tuberculosis orthologue Rv3099c (852 bp) (Best blastx scores: 271). Yes conserved hypotheticals Rv3099c Rv3099c AL450380.2 Mycobrowser_v4 CDS 814993 816276 . + 0 ML0680 ML0680 REP-family protein (pseudogene) ML0680, len: 1284 bp. Possible pseudogene similar to M. tuberculosis REP-family proteins (Best blastx scores: 392) Yes unknown AL450380.2 Mycobrowser_v4 CDS 816354 817056 . - 0 ML0681c ML0681c Possible methyltransferase (pseudogene) ML0681c, len: 703 bp. Possible pseudogene of M. tuberculosis orthologue Rv3342 (732 bp) (Best blastx scores: 374). Yes intermediary metabolism and respiration Rv3342 Rv3342 AL450380.2 Mycobrowser_v4 CDS 818273 819513 . - 0 ML0683c metC Probable O-acetyl-L-homoserine sulfhydrylase MetC (pseudogene) ML0683c, len: 1241 bp. Possible pseudogene of M. tuberculosis orthologue metC|Rv3340 (1350 bp) (Best blastx scores: 582) Yes intermediary metabolism and respiration Rv3340 Rv3340 AL450380.2 Mycobrowser_v4 CDS 819972 821101 . + 0 ML0684 icd1 Probable isocitrate dehydrogenase Icd1 (pseudogene) ML0684, len: 1130 bp. Possible pseudogene of M. tuberculosis orthologue icd1|Rv3339c (1230 bp) (Best blastx scores: 480) Yes intermediary metabolism and respiration Rv3339c Rv3339c AL450380.2 Mycobrowser_v4 CDS 2635361 2635935 . + 0 ML2218 ML2218 Hypothetical protein (pseudogene) ML2218, len: 575 bp. Possible pseudogene of M. tuberculosis orthologue Rv0789c (600 bp) (Best blastx scores: 122). Yes conserved hypotheticals Rv0789c Rv0789c AL450380.2 Mycobrowser_v4 CDS 1609957 1610609 . - 0 ML1349c ML1349c Probable conserved integral membrane protein ABC transporter (pseudogene) ML1349c, len: 653 bp. Possible pseudogene of M. tuberculosis orthologue Rv1686c (681 bp) (Best blastx scores: 406). Yes cell wall and cell processes Rv1686c Rv1686c AL450380.2 Mycobrowser_v4 CDS 813433 813960 . - 0 ML0678c ML0678c Hypothetical protein ML0678c, len: 175 aa. Hypothetical protein. Previously sequenced as O32876|Z98271 (175 aa), Fasta scores: E(): 0, (99.4% identity in 175 aa overlap). Q7AQG2 No unknown Q7AQG2 AL450380.2 Mycobrowser_v4 CDS 2169020 2169325 . + 0 ML1793 ML1793 hypothetical protein ML1793, len: 101 aa. Hypothetical unknown protein. Some similarity to other hypothetical proteins e.g. Q9I5F1 Hypothetical protein PA0787 from Pseudomonas aeruginosa (387 aa), fasta scores: E(): 2.1e-06, (41.237% identity in 97 aa overlap). Q9CBN0 No unknown Q9CBN0 AL450380.2 Mycobrowser_v4 CDS 1768622 1768993 . - 0 ML1470c ML1470c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN ML1470c, len: 123 aa. Probable conserved integral membrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2446c TR:O53173 (EMBL:AL021246) (123 aa), Fasta scores: E(): 1.5e-22, 66.7% identity in 108 aa overlap. Q9CBY9 No cell wall and cell processes Q9CBY9 Rv2446c Rv2446c AL450380.2 Mycobrowser_v4 CDS 1686378 1687126 . - 0 ML1404c ML1404c transposase (pseudogene) ML1404c, len: 749 bp. Possible pseudogene similar to many transposases e.g. Q53052 from Rhodococcus, TRA0_MYCSM|P35883 (carried on IS6120) from Mycobacterium smegmatis and Q9ZA68 (carried on IS666) from Mycobacterium avium. Also similar to several transposases from M. tuberculosis Rv3115, Rv3023c, Rv2512, Rv3431c etc. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1709621 1710382 . - 0 ML1422c ML1422c Conserved hypothetical protein (pseudogene) ML1422c, len: 762 bp. Possible pseudogene of M. tuberculosis orthologue Rv2033c (843 bp) (Best blastx scores: 279). Yes conserved hypotheticals Rv2033c Rv2033c AL450380.2 Mycobrowser_v4 CDS 2739770 2739877 . - 0 ML2311c ML2311c Conserved hypothetical protein (pseudogene) ML2311c, len: 108 bp. Possible pseudogene of M. tuberculosis orthologue Rv3688c (465 bp) (Best blastx scores: 125). Yes conserved hypotheticals Rv3688c Rv3688c AL450380.2 Mycobrowser_v4 CDS 2637059 2637296 . - 0 ML2220c ML2220c Hypothetical protein (pseudogene) ML2220c, len: 238 bp. Possible pseudogene of M. tuberculosis orthologue Rv0787 (960 bp) (Best blastx scores: 111). Yes conserved hypotheticals Rv0787 Rv0787 AL450380.2 Mycobrowser_v4 CDS 1837824 1838114 . - 0 ML1523c ML1523c hypothetical protein ML1523c, len: 96 aa. Hypothetical unknown protein. Q9CBV9 No unknown Q9CBV9 AL450380.2 Mycobrowser_v4 CDS 2517659 2518643 . - 0 ML2117c ML2117c Conserved hypothetical protein (pseudogene) ML2117c, len: 291 bp. Possible pseudogene of M. tuberculosis orthologue Rv0906 (1119 bp) (Best blastx scores: 599). Yes conserved hypotheticals Rv0906 Rv0906 AL450380.2 Mycobrowser_v4 CDS 2596788 2597130 . + 0 ML2182 ML2182 Probable transcriptional regulatory protein (ArsR family) (pseudogene) ML2182, len: 343 bp. Possible pseudogene of M. tuberculosis orthologue Rv0827c (393 bp) (Best blastx scores: 201). Yes regulatory proteins Rv0827c Rv0827c AL450380.2 Mycobrowser_v4 CDS 2597279 2598303 . - 0 ML2183c ML2183c Conserved hypothetical protein (pseudogene) ML2183c, len: 1025 bp. Possible pseudogene of M. tuberculosis orthologue Rv0826 (1056 bp) (Best blastx scores: 263). Yes conserved hypotheticals Rv0826 Rv0826 AL450380.2 Mycobrowser_v4 CDS 2649027 2649792 . + 0 ML2231 ML2231 Conserved hypothetical protein (pseudogene) ML2231, len: 766 bp. Possible pseudogene of M. tuberculosis orthologue Rv0776c (780 bp) (Best blastx scores: 364). Yes conserved hypotheticals Rv0776c Rv0776c AL450380.2 Mycobrowser_v4 CDS 2704488 2705474 . - 0 ML2280c gpdA1 Probable glycerol-3-phosphate dehydrogenase GpdA1(pseudogene) ML2280c, len: 987 bp. Possible pseudogene of M. tuberculosis orthologue gpdA1|Rv0564c (1026 bp) (Best blastx scores: 338). Yes lipid metabolism Rv0564c Rv0564c AL450380.2 Mycobrowser_v4 CDS 2739126 2739704 . + 0 ML2310A ML2310A Conserved hypothetical protein (pseudogene) ML2310A, len: 579 bp. Possible pseudogene similar to Q9RJD3 Hypothetical protein SCO0759 from Streptomyces coelicolor (343 aa) (Best blastx score: 151). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2774276 2774823 . + 0 ML2339 cut5b Probable cutinase precursor Cut5b (pseudogene) ML2339, len: 548 bp. Possible pseudogene of M. tuberculosis orthologue Rv3724B|cut5b (564 bp) (Best blastx scores: 340). Yes cell wall and cell processes Rv3724B Rv3724B AL450380.2 Mycobrowser_v4 CDS 2838511 2838831 . - 0 ML2369B ML2369B Hypothetical protein ML2369B, len: 107 aa. Hypothetical protein. No unknown AL450380.2 Mycobrowser_v4 CDS 2852008 2854017 . - 0 ML2382c ML2382c Probable peptidase (pseudogene) ML2382c, len: 2010 bp. Possible pseudogene of M. tuberculosis orthologue Rv0457c (2022 bp) (Best blastx scores: 580). Yes intermediary metabolism and respiration Rv0457c Rv0457c AL450380.2 Mycobrowser_v4 CDS 2854121 2855440 . + 0 ML2383 ML2383 Probable aldehyde dehydrogenase (pseudogene) ML2383, len: 1320 bp. Possible pseudogene of M. tuberculosis orthologue Rv0458 (1524 bp) (Best blastx scores: 356). Yes intermediary metabolism and respiration Rv0458 Rv0458 AL450380.2 Mycobrowser_v4 CDS 2263947 2264707 . - 0 ML1885c echA5 Probable enoyl-CoA hydratase EchA5 (pseudogene) ML1885c, len: 761 bp. Possible pseudogene of M. tuberculosis orthologue echA5|Rv0675 (792 bp) (Best blastx scores: 338). Yes lipid metabolism Rv0675 Rv0675 AL450380.2 Mycobrowser_v4 CDS 2667230 2667571 . - 0 ML2244c ML2244c hypothetical protein ML2244c, len: 113 aa. Hypothetical unknown protein. Q9CBC0 No unknown Q9CBC0 AL450380.2 Mycobrowser_v4 CDS 2262426 2262698 . - 0 ML1882c ML1882c Probable transcriptional regulatory protein (TetR family) (pseudogene) ML1882c, len: 273 bp. Possible pseudogene of M. tuberculosis orthologue Rv0681 (591 bp) (Best blastx scores: 194). Yes regulatory proteins Rv0681 Rv0681 AL450380.2 Mycobrowser_v4 CDS 2263085 2263379 . + 0 ML1883 ML1883 Probable conserved transmembrane protein (pseudogene) ML1883, len: 295 bp. Possible pseudogene of M. tuberculosis orthologue Rv0680c (375 bp) (Best blastx scores: 154). Yes cell wall and cell processes Rv0680c Rv0680c AL450380.2 Mycobrowser_v4 CDS 2263562 2263911 . + 0 ML1884 ML1884 Conserved hypothetical threonine rich protein (pseudogene) ML1884, len: 350 bp. Possible pseudogene of M. tuberculosis orthologue Rv0679c (498 bp) (Best blastx scores: 155). Yes conserved hypotheticals Rv0679c Rv0679c AL450380.2 Mycobrowser_v4 CDS 2278448 2279763 . - 0 ML1893c ML1893c Probable dioxygenase (pseudogene) ML1893c, len: 1316 bp. Possible pseudogene of M. tuberculosis orthologue Rv0654 (1506 bp) (Best blastx scores: 240). Yes intermediary metabolism and respiration Rv0654 Rv0654 AL450380.2 Mycobrowser_v4 CDS 2360799 2361056 . + 0 ML1975 ML1975 Probable oxidoreductase (pseudogene) ML1975, len: 258 bp. Possible pseudogene similar to several oxidoreductases e.g. Q9RK29|AL132856 probable oxidoreductase SCF15.08C from Streptomyces coelicolor (792 bp) (blastx scores:: 99). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2651734 2653213 . + 0 ML2234 ggtA Probable bifunctional acylase GgtA: cephalosporin acylase and gamma-glutamyl transpeptidase (pseudogene) ML2234, len: 1480 bp. Possible pseudogene of M. tuberculosis orthologue ggtA|Rv0773c (1539 bp) (Best blastx scores: 208). Yes intermediary metabolism and respiration Rv0773c Rv0773c AL450380.2 Mycobrowser_v4 CDS 2314828 2315241 . + 0 ML1932 ML1932 POSSIBLE TRANSMEMBRANE PROTEIN ML1932, len: 137 aa. Possible transmembrane protein. Similar to M. tuberculosis transmembrane protein Rv0426c TR:P96272 (EMBL:Z84724) (147 aa), Fasta scores: E(): 1.6e-22, 60.4% identity in 139 aa overlap. Q9CBI1 No cell wall and cell processes Q9CBI1 Rv0426c Rv0426c AL450380.2 Mycobrowser_v4 CDS 2656936 2658278 . - 0 ML2238c phoR Possible two component system membrane-associated sensor kinase PhoR (pseudogene) ML2238c, len: 1343 bp. Possible pseudogene of M. tuberculosis orthologue phoR|Rv0758 (1458 bp) (Best blastx scores: 378). Yes regulatory proteins Rv0758 Rv0758 AL450380.2 Mycobrowser_v4 CDS 2747159 2747806 . - 0 ML2320c ML2320c conserved hypothetical protein ML2320c, len: 215 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 22.4 kDa protein Rv3705c TR:O69673 (EMBL:AL022121) (214 aa) fasta scores: E(): 0, 79.4% identity in 214 aa. Q9CB80 No conserved hypotheticals Q9CB80 Rv3705c Rv3705c AL450380.2 Mycobrowser_v4 CDS 2554068 2554321 . + 0 ML2150 moaD2 Probable molybdenum cofactor biosynthesis protein MoaD2 (pseudogene) ML2150, len: 254 bp. Possible pseudogene of M. tuberculosis orthologue moaD2|Rv0868c (279 bp) (Best blastx scores: 134). Yes intermediary metabolism and respiration Rv0868c Rv0868c AL450380.2 Mycobrowser_v4 CDS 2605949 2606705 . - 0 ML2191c ML2191c Phosphate-transport integral membrane ABC transporter (pseudogene) ML2191c, len: 757 bp. Possible pseudogene similar to M. tuberculosis pstC2|Rv0929 (975 bp) (Best blastx scores: 327), also similar to ML2094c a possible orthologue of M. tuberculosis pstC2. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2655609 2656363 . + 0 ML2236 ML2236 REP13E12-family protein (pseudogene) ML2236, len: 755 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins in REP13E12 degenerate repeate.g. Rv1148, Rv1702, Rv1945, Rv1148, Rv3467 (Best blastx scores: 229). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2759844 2760415 . - 0 ML2328c ML2328c Conserved hypothetical protein (pseudogene) ML2328c, len: 572 bp. Possible pseudogene similar to M. tuberculosis orthologue Rv3714c (891 bp) (Best blastx scores: 159). Also similar to ML1047c and ML1943c possible pseudogenes similar to M. tuberculosis Rv3714c. Yes conserved hypotheticals Rv3714c Rv3714c AL450380.2 Mycobrowser_v4 CDS 2786397 2786814 . + 0 ML2345 ML2345 Probable transcriptional regulatory protein (Crp/Fnr family) (pseudogene) ML2345, len: 418 bp. Possible pseudogene similar to M. tuberculosis Rv3676 (Best blastx scores: 204), also similar to ML2302 a possible orthologue of M. tuberculosis Rv3676. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2312438 2312575 . - 0 ML1928c ML1928c hypothetical protein ML1928c, len: 45 aa. Hypothetical protein (doutful CDS). Q9CBI3 No unknown Q9CBI3 AL450380.2 Mycobrowser_v4 CDS 2336284 2336643 . - 0 ML1949c ML1949c hypothetical protein ML1949c, len: 119 aa. Hypothetical unknown protein. Q9CBH8 No unknown Q9CBH8 AL450380.2 Mycobrowser_v4 CDS 2707739 2708053 . + 0 ML2283 ML2283 hypothetical protein ML2283, len: 104 aa. Hypothetical unknown protein. Q9CBA2 No unknown Q9CBA2 AL450380.2 Mycobrowser_v4 CDS 2658345 2659051 . - 0 ML2239c phoP Possible two component system response transcriptional positive regulator PhoP (pseudogene) ML2239c, len: 707 bp. Possible pseudogene of M. tuberculosis orthologue phoP|Rv0757 (744 bp) (Best blastx scores: 386). Yes regulatory proteins Rv0757 Rv0757 AL450380.2 Mycobrowser_v4 CDS 2659233 2659667 . + 0 ML2240 ML2240 Hypothetical protein (pseudogene) ML2240, len: 435 bp. Possible pseudogene of M. tuberculosis orthologue Rv0756c (726 bp) (Best blastx scores: 180). Yes conserved hypotheticals Rv0756c Rv0756c AL450380.2 Mycobrowser_v4 CDS 2666714 2667001 . - 0 ML2243c ML2243c PPE-family protein (pseudogene) ML2243c, len: 288 bp. Possible pseudogene similar to several M. tuberculosis PPE-family proteins e.g. PPE57|Rv3459, PPE58|Rv3426 or PPE59|Rv3429. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2667797 2668390 . - 0 ML2245c ML2245c Monomeric sarcosine oxidase (pseudogene) ML2245c, len: 594 bp. Similar to P40854|MSOX_STRSQ Monomeric sarcosine oxidase from Streptomyces sp (1164 bp) (Blastx scores:: 236). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2669339 2670009 . - 0 ML2246c ML2246c Probable conserved membrane protein (pseudogene) ML2246c, len: 671 bp. Possible pseudogene of M. tuberculosis orthologue Rv3482c (783 bp) (Best blastx scores: 128). Yes cell wall and cell processes Rv3482c Rv3482c AL450380.2 Mycobrowser_v4 CDS 2672144 2672692 . - 0 ML2248c ML2248c Probable dehydrogenase/reductase (pseudogene) ML2248c, len: 549 bp. Possible pseudogene similar to M. tuberculosis family of short-chain type dehydrogenases/reductases e.g. Rv3057, FabG3|Rv2002, Rv0712, FabG2|Rv1350 etc (Best blastx scores: 301). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2898962 2899255 . - 0 ML2423c ML2423c Conserved hypothetical protein (pseudogene) ML2423c, len: 294 bp. Possible pseudogene of M. tuberculosis orthologue Rv0508 (294 bp) (Best blastx scores: 249) Yes conserved hypotheticals Rv0508 Rv0508 AL450380.2 Mycobrowser_v4 CDS 3069804 3070547 . + 0 ML2571 ML2571 Possible glycerophosphoryl diester phosphodiesterase (pseudogene) ML2571, len: 744 bp. Possible pseudogene similar to M. tuberculosis glpQ2|Rv0317c (771 bp) (Best blastx scores: 338). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2990515 2991103 . + 0 ML2509 ML2509 Hypothetical protein (pseudogene) ML2509, len: 589 bp. Possible pseudogene similar to M. tuberculosis Rv2826c (885 bp) (Best blastx scores: 189). Yes unknown AL450380.2 Mycobrowser_v4 CDS 3036714 3037430 . + 0 ML2548 ML2548 Probable iron-transport lipoprotein (pseudogene) ML2548, len: 717 bp. Possible pseudogene of M. tuberculosis orthologue Rv0265c (993 bp) (Best blastx scores: 370). Yes cell wall and cell processes Rv0265c Rv0265c AL450380.2 Mycobrowser_v4 CDS 2890131 2890523 . - 0 ML2416A ML2416A Hypothetical protein ML2416A, len: 130 aa. Hypothetical protein. No unknown AL450380.2 Mycobrowser_v4 CDS 2974125 2974598 . + 0 ML2497 ML2497 hypothetical protein ML2497, len: 157 aa. Hypothetical unknown protein. Q9CB22 No unknown Q9CB22 AL450380.2 Mycobrowser_v4 CDS 3054595 3054885 . + 0 ML2562 ML2562 hypothetical protein ML2562, len: 96 aa. Hypothetical unknown protein. Q9CD23 No unknown Q9CD23 AL450380.2 Mycobrowser_v4 CDS 2354068 2355211 . - 0 ML1970c ML1970c Putative group II intron maturase-related protein (pseudogene) ML1970c, len: 1144 bp. Possible pseudogene, similar to several maturases e.g. Q9MD87|AF218567 putative maturase from Cryphonectria parasitica (Cheshnut blight fungus) (2334 bp), (blastx scores: 143); and Rv0071|O53616 Putative maturase from M. tuberculosis (705 bp), (blastx scores: 153). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2893256 2893769 . - 0 ML2418c ML2418c Possible conserved transmembrane protein (pseudogene) ML2418c, len: 514 bp. Possible pseudogene of M. tuberculosis orthologue Rv0513 (549 bp) (Best blastx scores: 170). Yes cell wall and cell processes Rv0513 Rv0513 AL450380.2 Mycobrowser_v4 CDS 863379 863779 . + 0 ML0720 lrpA Probable transcriptional regulatory protein (probably AsnC family) (pseudogene) ML0720, len: 401 bp. Possible pseudogene of M. tuberculosis orthologue Rv3291c (453 bp) (Best blastx scores: 358). Yes regulatory proteins Rv3291c Rv3291c AL450380.2 Mycobrowser_v4 CDS 511131 511984 . + 0 ML0413 htdY Possible dehydrogenase (pseudogene) ML0413, len: 854 bp. Possible pseudogene of M. tuberculosis orthologue Rv3389c (873 bp) (Best blastx scores: 301) Yes intermediary metabolism and respiration Rv3389c Rv3389c AL450380.2 Mycobrowser_v4 CDS 433561 434729 . + 0 ML0343 hsaA Possible oxidoreductase (pseudogene) ML0343, len: 1169 bp. Possible pseudogene of M. tuberculosis orthologue Rv3570c (1185 bp) (Best blastx scores: 413) Yes intermediary metabolism and respiration Rv3570c Rv3570c AL450380.2 Mycobrowser_v4 CDS 2919429 2920405 . - 0 ML2444c ML2444c Possible transcriptional regulatory protein (NAGC/XYLR repressor family) (pseudogene) ML2444c, len: 977 bp. Possible pseudogene of M. tuberculosis orthologue Rv0485 (1317 bp) (Best blastx scores: 222). Yes regulatory proteins Rv0485 Rv0485 AL450380.2 Mycobrowser_v4 CDS 2929438 2930042 . - 0 ML2456c ML2456c Possible conserved transmembrane protein (pseudogene) ML2456c, len: 605 bp. Possible pseudogene of M. tuberculosis orthologue Rv0473 (1371 bp) (Best blastx scores: 282). Yes cell wall and cell processes Rv0473 Rv0473 AL450380.2 Mycobrowser_v4 CDS 2944210 2944950 . + 0 ML2469 proV Possible osmoprotectant transport ATP-binding protein ABC transporter ProV (pseudogene) ML2469, len: 741 bp. Possible pseudogene of M. tuberculosis orthologue proV|Rv3758c (1131 bp) (Best blastx scores: 167). Yes virulence, detoxification, adaptation Rv3758c Rv3758c AL450380.2 Mycobrowser_v4 CDS 2731470 2731820 . - 0 ML2307c whiB4 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB4 ML2307c, len: 116 aa. Probable whiB4, WhiB-like regulatory protein. Similar in part to Mycobacterium tuberculosis putative regulatory protein Rv3681c TR:O69649 (EMBL:AL022121) (118 aa) fasta scores: E(): 3e-32, 89.7% identity in 78 aa. Q9CB86 No regulatory proteins PF02467 Q9CB86 Rv3681c Rv3681c AL450380.2 Mycobrowser_v4 CDS 2479505 2479644 . + 0 ML2085 ML2085 Possible transposase remnant (pseudogene) ML2085, len: 140 bp. Possible transposase remnant, some similarity to Q9RBZ3 transposase from Pseudomonas syringae (1071 bp), (blastx scores: 51) and to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 45). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 3002824 3004019 . - 0 ML2520c ML2520c Hypothetical protein (pseudogene) ML2520c, len: 1196 bp. Possible pseudogene of M. tuberculosis orthologue Rv0311 (1230 bp) (Best blastx scores: 556). Yes conserved hypotheticals Rv0311 Rv0311 AL450380.2 Mycobrowser_v4 CDS 2949487 2950378 . - 0 ML2475c ML2475c Possible glycerolphosphodiesterase (pseudogene) ML2475c, len: 892 bp. Possible pseudogene similar to M. tuberculosis Rv2277c (906 bp) (Best blastx scores: 197). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2471165 2472091 . - 0 ML2080c ML2080c Conserved hypothetical protein (pseudogene) ML2080c, len: 927 bp. Possible pseudogene of M. tuberculosis orthologue Rv1823 (924 bp) (Best blastx scores: 305). Yes conserved hypotheticals Rv1823 Rv1823 AL450380.2 Mycobrowser_v4 CDS 2513079 2513807 . - 0 ML2112c ML2112c Conserved hypothetical protein (pseudogene) ML2112c, len: 729 bp. Possible pseudogene of M. tuberculosis orthologue Rv0911 (774 bp) (Best blastx scores: 142). Yes conserved hypotheticals Rv0911 Rv0911 AL450380.2 Mycobrowser_v4 CDS 2937784 2939179 . + 0 ML2464 ML2464 Probable transcriptional regulatory protein (pseudogene) ML2464, len: 1396 bp. Possible pseudogene of M. tuberculosis orthologue Rv0465c (1425 bp) (Best blastx scores: 434). Yes regulatory proteins Rv0465c Rv0465c AL450380.2 Mycobrowser_v4 CDS 2956320 2956864 . - 0 ML2480c ML2480c Possible membrane oxidoreductase (pseudogene) ML2480c, len: 545 bp. Possible pseudogene of M. tuberculosis orthologue Rv0369c (516 bp) (Best blastx scores: 241). Yes intermediary metabolism and respiration Rv0369c Rv0369c AL450380.2 Mycobrowser_v4 CDS 1928853 1929242 . - 0 ML1604c ML1604c hypothetical protein ML1604c, len: 129 aa. Hypothetical unknown protein. Similar in part to Nikkomycin biosynthesis proteins e.g. Q9RCK6 Nikkomycin biosynthesis protein from Streptomyces tendae (471 aa), fasta scores: E(): 0.0019, (49.020% identity in 51 aa overlap). Q9CBT7 No unknown Q9CBT7 AL450380.2 Mycobrowser_v4 CDS 2957693 2958101 . - 0 ML2482c ML2482c Conserved hypothetical protein (pseudogene) ML2482c, len: 409 bp. Possible pseudogene of M. tuberculosis orthologue Rv0371c (594 bp) (Best blastx scores: 148). Yes conserved hypotheticals Rv0371c Rv0371c AL450380.2 Mycobrowser_v4 CDS 1378899 1379314 . + 0 ML1179B ML1179B hypothetical protein(pseudogene) ML1179B, len:415. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-24 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2849887 2850216 . - 0 ML2379c ML2379c Conserved hypothetical protein ML2379c, len: 109 aa. Conserved hypothetical protein, similar in part to Q8VKL1 Hypothetical protein MT0470 from M. tuberculosis CDC1551 (184 aa), fasta scores: E(): 7.2e-26, (58.879% identity in 107 aa overlap). Q9CB69 No conserved hypotheticals Q9CB69 AL450380.2 Mycobrowser_v4 CDS 1919061 1920363 . - 0 ML1594c ML1594c Possible multidrug resistance integral membrane efflux protein (pseudogene) ML1594c, len: 1303 bp. Possible pseudogene similar to M. tuberculosis Rv0783c|emrB (1623 bp) (Best blastx scores: 335). Also similar to ML2224 a possible pseudogene similar to M. tuberculosis emrB. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1379419 1380228 . + 0 ML1179C ML1179C hypothetical protein(pseudogene) ML1179C, len:809. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-15 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1383009 1383345 . + 0 ML1183A ML1183A hypothetical protein(pseudogene) ML1183A, len:336. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1384768 1385145 . - 0 ML1184A ML1184A hypothetical protein(pseudogene) ML1184A, len:377. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-23 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1385173 1385718 . - 0 ML1185A ML1185A hypothetical protein(pseudogene) ML1185A, len:545. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-20 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2999824 3000216 . - 0 ML2518c ML2518c conserved hypothetical protein ML2518c, len: 130 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0313 TR:O07240 (EMBL:Z96800) fasta scores: E(): 0, 77.3% identity in 128 aa. Q9CD39 No conserved hypotheticals Q9CD39 Rv0313 Rv0313 AL450380.2 Mycobrowser_v4 CDS 1255678 1256447 . - 0 ML1092c PE_PGRS3 PE_PGRS-family protein (pseudogene) ML1092c, len: 770 bp. Possible pseudogene of M. tuberculosis orthologue PE_PGRS23|Rv1243c (1689 bp) (Best blastx scores: 184). Yes PE/PPE Rv1243c Rv1243c AL450380.2 Mycobrowser_v4 CDS 3243531 3244340 . + 0 ML2694 ML2694 Possible oxidoreductase (pseudogene) ML2694, len: 810 bp. Possible pseudogene of M. tuberculosis orthologue Rv0044c (795 bp) (Best blastx scores: 394). Yes intermediary metabolism and respiration Rv0044c Rv0044c AL450380.2 Mycobrowser_v4 CDS 2402980 2403441 . + 0 ML2010 ML2010 CONSERVED HYPOTHETICAL PROTEIN ML2010, len: 153 aa. Conserved hypothetical protein, possibly exported protein. Similar to M. tuberculosis hypothetical protein Rv1906c TR:O07726 (EMBL:Z97193) (156 aa), Fasta scores: E(): 2.6e-31, 63.2% identity in 155 aa overlap. Q7AQ06 No conserved hypotheticals Q7AQ06 Rv1906c Rv1906c AL450380.2 Mycobrowser_v4 CDS 2405363 2405743 . - 0 ML2013c ML2013c hypothetical protein ML2013c, len: 126 aa. Hypothetical unknown protein. Q7AQ03 No unknown Q7AQ03 AL450380.2 Mycobrowser_v4 CDS 2410790 2411209 . + 0 ML2019 ML2019 Conserved hypothetical protein (pseudogene) ML2019, len: 420 bp. Possible pseudogene of M. tuberculosis orthologue Rv1897c (432 bp) (Best blastx scores: 256) Yes conserved hypotheticals Rv1897c Rv1897c AL450380.2 Mycobrowser_v4 CDS 2412524 2413592 . + 0 ML2021 ML2021 Conserved hypothetical protein (pseudogene) ML2021, len: 1069 bp. Possible pseudogene of M. tuberculosis orthologue Rv1894c (1131 bp) (Best blastx scores: 252). Yes conserved hypotheticals Rv1894c Rv1894c AL450380.2 Mycobrowser_v4 CDS 2416476 2416766 . + 0 ML2025 ML2025 alcohol dehydrogenase (pseudogene) ML2025, len: 291 bp. Possible pseudogene similar to part of several alcohol dehydrogenases e.g. ADH2_EMENI|P54202 Emericella nidulans alcohol dehydrogenase II (367 aa) (best blastx score: 109). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2417268 2417772 . + 0 ML2026 ML2026 Hypothetical protein (pseudogene) ML2026, len: 505 bp. Possible pseudogene of M. tuberculosis orthologue Rv1890c (612 bp) (Best blastx scores: 232). Yes conserved hypotheticals Rv1890c Rv1890c AL450380.2 Mycobrowser_v4 CDS 2417829 2418442 . - 0 ML2027c ML2027c Hypothetical protein (pseudogene) ML2027c, len: 614 bp. Possible pseudogene of M. tuberculosis orthologue Rv1887 (1143 bp) (Best blastx scores: 238). Yes conserved hypotheticals Rv1887 Rv1887 AL450380.2 Mycobrowser_v4 CDS 2420004 2420554 . + 0 ML2029 ML2029 Conserved hypothetical protein (pseudogene) ML2029, len: 551 bp. Possible pseudogene of M. tuberculosis orthologue Rv1885c (600 bp) (Best blastx scores: 180). Yes intermediary metabolism and respiration Rv1885c Rv1885c AL450380.2 Mycobrowser_v4 CDS 2421761 2422166 . + 0 ML2032 lppE Possible conserved lipoprotein LppE (pseudogene) ML2032, len: 406 bp. Possible pseudogene of M. tuberculosis orthologue lppE|Rv1881c (423 bp) (Best blastx scores: 135). Yes cell wall and cell processes Rv1881c Rv1881c AL450380.2 Mycobrowser_v4 CDS 2422762 2424066 . + 0 ML2033 cyp140 Probable cytochrome p450 140 Cyp140 (pseudogene) ML2033, len: 1305 bp. Possible pseudogene of M. tuberculosis orthologue Rv1880c|cyp140 (1317 bp) (Best blastx scores: 323). Yes intermediary metabolism and respiration Rv1880c Rv1880c AL450380.2 Mycobrowser_v4 CDS 3213371 3214600 . + 0 ML2673 ML2673 Two component sensor histidine kinase (pseudogene) ML2673, len: 1230 bp. Possible pseudogene similar to M. tuberculosis orthologue Rv0902c|prrB (1341 bp) (Best blastx scores: 369). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2424802 2425052 . + 0 ML2034 ML2034 Conserved hypothetical protein (pseudogene) ML2034, len: 251 bp. Possible pseudogene similar to M. tuberculosis Rv2675c (753 bp) (Best blastx scores: 77). Also similar to ML1046 a possible pseudogene similar to M. tuberculosis Rv2675c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2426745 2427751 . - 0 ML2036c ML2036c Conserved hypothetical protein (pseudogene) ML2036c, len: 1007 bp. Possible pseudogene of M. tuberculosis orthologue Rv1879 (1137 bp) (Best blastx scores: 279). Yes conserved hypotheticals Rv1879 Rv1879 AL450380.2 Mycobrowser_v4 CDS 3242604 3243503 . + 0 ML2693 ML2693 Possible hydrolase (pseudogene) ML2693, len: 900 bp. Possible pseudogene of M. tuberculosis orthologue Rv0045c (897 bp) (Best blastx scores: 228). Yes lipid metabolism Rv0045c Rv0045c AL450380.2 Mycobrowser_v4 CDS 1684766 1685402 . + 0 ML1403 PE_PGRS4 PE-PGRS family protein (pseudogene) ML1403, len: 637 bp. Possible pseudogene of M. tuberculosis orthologue PE_PGRS30|Rv1651c (3036 bp) (Best blastx scores: 230). Yes PE/PPE Rv1651c Rv1651c AL450380.2 Mycobrowser_v4 CDS 2413651 2414175 . - 0 ML2022c ML2022c conserved hypothetical protein ML2022c, len: 174 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv1893 TR:O07739 (EMBL:Z97193) (72 aa), Fasta scores: E(): 3e-13, 69.4% identity in 72 aa overlap. Q9CBF9 No conserved hypotheticals Q9CBF9 Rv1893 Rv1893 AL450380.2 Mycobrowser_v4 CDS 3228566 3229135 . + 0 ML2679A ML2679A Hypothetical protein ML2679A, len: 189 aa. Hypothetical protein. No unknown AL450380.2 Mycobrowser_v4 CDS 2414271 2414675 . - 0 ML2023c ML2023c CONSERVED HYPOTHETICAL PROTEIN ML2023c, len: 134 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv1891 TR:O07741 (EMBL:Z97193) (135 aa), Fasta scores: E(): 0, 79.7% identity in 133 aa overlap. Q7AQ02 No conserved hypotheticals Q7AQ02 Rv1891 Rv1891 AL450380.2 Mycobrowser_v4 CDS 2425173 2425436 . - 0 ML2035c ML2035c hypothetical protein ML2035c, len: 87 aa. Hypothetical unknown protein. Q9CBF6 No unknown Q9CBF6 AL450380.2 Mycobrowser_v4 CDS 2498692 2499840 . + 0 ML2102 ML2102 Probable hydrolase lipase (pseudogene) ML2102, len: 1149 bp. Possible pseudogene similar to M. tuberculosis lipD|Rv1923 (1341 bp) (Best blastx scores: 311) and also similar to lipL|Rv1497. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2500779 2501545 . - 0 ML2103c ML2103c Conserved hypothetical protein (pseudogene) ML2103c, len: 767 bp. Possible pseudogene of M. tuberculosis orthologue Rv2631 (1299 bp) (Best blastx scores: 259). Yes conserved hypotheticals Rv2631 Rv2631 AL450380.2 Mycobrowser_v4 CDS 2501674 2502006 . - 0 ML2104c ML2104c Hypothetical protein (pseudogene) ML2104c, len: 333 bp. Possible pseudogene of M. tuberculosis orthologue Rv2630 (540 bp) (Best blastx scores: 180). Yes conserved hypotheticals Rv2630 Rv2630 AL450380.2 Mycobrowser_v4 CDS 2502414 2503147 . - 0 ML2105c ML2105c Conserved hypothetical protein (pseudogene) ML2105c, len: 734 bp. Possible pseudogene of M. tuberculosis orthologue Rv0574c (1143 bp) (Best blastx scores: 197). Yes conserved hypotheticals Rv0574c Rv0574c AL450380.2 Mycobrowser_v4 CDS 2503375 2504642 . + 0 ML2106 ML2106 Conserved hypothetical protein (pseudogene) ML2106, len: 1268 bp. Possible pseudogene of M. tuberculosis orthologue Rv0571c (1332 bp) (Best blastx scores: 879). Yes conserved hypotheticals Rv0571c Rv0571c AL450380.2 Mycobrowser_v4 CDS 2740952 2741554 . + 0 ML2313 ML2313 conserved hypothetical protein ML2313, len: 200 aa. Conserved hypothetical protein. Similar to several hypothetical proteins e.g. Q827D0 Hypothetical protein from Streptomyces avermitilis (217 aa), fasta scores: E(): 4.8e-28, (49.468% identity in 188 aa overlap) Q9CB82 No conserved hypotheticals PF03551 Q9CB82 AL450380.2 Mycobrowser_v4 CDS 2507112 2507438 . - 0 ML2107c ML2107c Conserved hypothetical protein (pseudogene) ML2107c, len: 327 bp. Possible pseudogene of M. tuberculosis orthologue Rv0919 (501 bp) (Best blastx scores: 197). Yes intermediary metabolism and respiration Rv0919 Rv0919 AL450380.2 Mycobrowser_v4 CDS 2522203 2523804 . + 0 ML2122 ML2122 Conserved hypothetical protein (pseudogene) ML2122, len: 1602 bp. Possible pseudogene similar to M. tuberculosis Rv0785 (1701 bp) (Best blastx scores: 219). Also similar to ML2222 a possible pseudogene similar to M. tuberculosis Rv0785. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2526244 2526630 . - 0 ML2125c ML2125c Possible conserved exported or membrane protein (pseudogene) ML2125c, len: 387 bp. Possible pseudogene of M. tuberculosis orthologue Rv0901 (528 bp) (Best blastx scores: 154). Yes cell wall and cell processes Rv0901 Rv0901 AL450380.2 Mycobrowser_v4 CDS 2579216 2579440 . - 0 ML2170c ML2170c hypothetical protein ML2170c, len: 74 aa. Hypothetical unknown protein. Q9CBD5 No unknown Q9CBD5 AL450380.2 Mycobrowser_v4 CDS 2528076 2529423 . + 0 ML2127 ML2127 Probable oxidoreductase (pseudogene) ML2127, len: 1348 bp. Possible pseudogene of M. tuberculosis orthologue Rv0897c (1608 bp) (Best blastx scores: 236). Yes intermediary metabolism and respiration Rv0897c Rv0897c AL450380.2 Mycobrowser_v4 CDS 2529434 2530551 . - 0 ML2128c ML2128c PPE-family protein (pseudogene) ML2128c, len: 1118 bp. Possible pseudogene similar to several M. tuberculosis PPE-family proteins e.g. PPE2|Rv0256c, PPE4|Rv0286, PPE3|Rv0280, PPE66|Rv3738c etc (Best blastx scores: 182). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2555760 2556148 . - 0 ML2153c mog Probable molybdopterin biosynthesis protein Mog (pseudogene) ML2153c, len: 389 bp. Possible pseudogene of M. tuberculosis orthologue mog|Rv0865 (483 bp) (Best blastx scores: 218). Yes intermediary metabolism and respiration Rv0865 Rv0865 AL450380.2 Mycobrowser_v4 CDS 3219527 3219880 . - 0 ML2675A ML2675A Hypothetical protein ML2675A, len: 117 aa. Hypothetical protein. No unknown AL450380.2 Mycobrowser_v4 CDS 3150514 3151129 . - 0 ML2633c ML2633c Probable transcriptional regulatory protein (TetR/AcrR family) (pseudogene) ML2633c, len: 616 bp. Possible pseudogene of M. tuberculosis orthologue Rv0158 (645 bp) (Best blastx scores: 272). Yes regulatory proteins Rv0158 Rv0158 AL450380.2 Mycobrowser_v4 CDS 2512546 2512980 . - 0 ML2111c ML2111c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2111c, len: 144 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 15.4 kda protein TR:O05904 (EMBL:Z95210) fasta scores: E(): 0, 69.5% in 141 aa. Q50121 No cell wall and cell processes Q50121 Rv0912 Rv0912 AL450380.2 Mycobrowser_v4 CDS 3151318 3151431 . + 0 ML2633A ML2633A HYPOTHETICAL PROTEIN (pseudogene) ML2633A, len: 114 bp. Possible pseudogene similar to M. tuberculosis orthologue Rv0157A (129 bp) (Best blastx scores: 159). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2521547 2521957 . - 0 ML2121c ML2121c conserved hypothetical protein ML2121c, len: 136 aa. Conserved hypothetical protein. Some similarity to SC5F8.13|AL357613|Q9K4L1 Streptomyces coelicolor putative TetR-family regulator (193 aa), fasta scores: E(): 4.6e-12, (48.5% in 97 aa). Q7APY9 No conserved hypotheticals Q7APY9 AL450380.2 Mycobrowser_v4 CDS 3191593 3191913 . + 0 ML2665 ML2665 Probable peptide synthetase (pseudogene) ML2665, len: 321 bp. Possible pseudogene similar to M. tuberculosis nrp|Rv0101 (7539 bp) (Best blastx scores: 114). Also similar to ML1996 a possible orthologue of M. tuberculosis nrp. Yes unknown AL450380.2 Mycobrowser_v4 CDS 3234599 3234855 . - 0 ML2686c ML2686c Conserved hypothetical protein (pseudogene) ML2686c, len: 257 bp. Possible pseudogene of M. tuberculosis orthologue Rv0052 (564 bp) (Best blastx scores: 74). Yes conserved hypotheticals Rv0052 Rv0052 AL450380.2 Mycobrowser_v4 CDS 3133980 3134968 . + 0 ML2623 ML2623 Hypothetical protein (pseudogene) ML2623, len: 989 bp. Possible pseudogene of M. tuberculosis orthologue Rv0210 (1479 bp) (Best blastx scores: 168). Yes conserved hypotheticals Rv0210 Rv0210 AL450380.2 Mycobrowser_v4 CDS 3220869 3221603 . - 0 ML2676c ML2676c Probable oxidoreductase (pseudogene) ML2676c, len: 735 bp. Possible pseudogene of M. tuberculosis orthologue Rv0077c (831 bp) (Best blastx scores: 201). Yes intermediary metabolism and respiration Rv0077c Rv0077c AL450380.2 Mycobrowser_v4 CDS 3232122 3232582 . - 0 ML2681c ML2681c Hypothetical protein (pseudogene) ML2681c, len: 461 bp. Possible pseudogene of M. tuberculosis orthologue Rv0057 (522 bp) (Best blastx scores: 166). Yes conserved hypotheticals Rv0057 Rv0057 AL450380.2 Mycobrowser_v4 CDS 3256950 3257105 . + 0 ML2701 sigM Possible alternative RNA polymerase sigma factor sigM (pseudogene) ML2701, len: 156 bp. Possible pseudogene of M. tuberculosis orthologue sigM|Rv3911 (669 bp) (Best blastx scores: 88). Yes information pathways Rv3911 Rv3911 AL450380.2 Mycobrowser_v4 CDS 3266789 3267109 . - 0 ML2711c ML2711c Possible hemolysin (pseudogene) ML2711c, len: 321 bp. Possible pseudogene of M. tuberculosis orthologue Rv3922c (363 bp) (Best blastx scores: 369). Yes virulence, detoxification, adaptation Rv3922c Rv3922c AL450380.2 Mycobrowser_v4 CDS 2862586 2863020 . + 0 ML2392 ML2392 PROBABLE CONSERVED MEMBRANE PROTEIN ML2392, len: 144 aa. Probable conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1081c TR:O53429 (EMBL:AL021897) (144 aa) fasta scores: E(): 0, 69.0% id in 142 aa. Contains a possible membrane spanning hydrophobic domain. Q9CB66 No cell wall and cell processes Q9CB66 Rv1081c Rv1081c AL450380.2 Mycobrowser_v4 CDS 2016967 2018398 . - 0 ML1672c ML1672c Conserved hypothetical protein (pseudogene) ML1672c, len: 1432 bp. Possible pseudogene of M. tuberculosis orthologue Rv2974c (1413 bp) (Best blastx scores: 719). Yes conserved hypotheticals Rv2974c Rv2974c AL450380.2 Mycobrowser_v4 CDS 1913064 1913881 . - 0 ML1588c ML1588c Conserved hypothetical protein (pseudogene) ML1588c, len: 818 bp. Possible pseudogene of M. tuberculosis orthologue Rv2880c (828 BP) (Best blastx scores: 295). Yes conserved hypotheticals Rv2880c Rv2880c AL450380.2 Mycobrowser_v4 CDS 1917195 1917871 . + 0 ML1592 ML1592 Probable transcriptional regulatory protein (pseudogene) ML1592, len: 677 bp. Possible pseudogene of M. tuberculosis orthologue Rv2884 (759 bp) (Best blastx scores: 260). Yes regulatory proteins Rv2884 Rv2884 AL450380.2 Mycobrowser_v4 CDS 1928383 1928643 . - 0 ML1603c ML1603c hypothetical protein ML1603c, len: 86 aa. Hypothetical unknown protein. Q9CBT8 No unknown Q9CBT8 AL450380.2 Mycobrowser_v4 CDS 2011299 2012081 . - 0 ML1668c lipN Probable lipase/esterase LipN (pseudogene) ML1668c, len: 783 bp. Possible pseudogene of M. tuberculosis orthologue lipN|Rv2970c (1131 bp) (Best blastx scores: 135). Yes intermediary metabolism and respiration Rv2970c Rv2970c AL450380.2 Mycobrowser_v4 CDS 1057488 1057880 . + 0 ML0891 ML0891 conserved hypothetical protein ML0891, len: 130 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2183c TR:O53517 (EMBL:AL021957) (131 aa), Fasta scores: E(): 1.3e-30, 62.6% identity in 131 aa overlap. Previously sequenced Mycobacterium leprae hypothetical protein TR:O69573 (EMBL:AL022602) (130 aa), Fasta scores: E(): 0, 100.0% identity in 130 aa overlap. Q7AQD8 No conserved hypotheticals Q7AQD8 Rv2183c Rv2183c AL450380.2 Mycobrowser_v4 CDS 1098590 1099189 . + 0 ML0929 mgtC Possible magnesium transport ATPase protein C MgtC (pseudogene) ML0929, len: 600 bp. Possible pseudogene of M. tuberculosis orthologue mgtC|Rv1811 (705 bp) (Best blastx scores: 171). Yes cell wall and cell processes Rv1811 Rv1811 AL450380.2 Mycobrowser_v4 CDS 1099220 1100064 . - 0 ML0930c ML0930c Probable dehydrogenase (pseudogene) ML0930c, len: 845 bp. Possible pseudogene of M. tuberculosis orthologue Rv1812c (1203 bp) (Best blastx scores: 260). Yes intermediary metabolism and respiration Rv1812c Rv1812c AL450380.2 Mycobrowser_v4 CDS 1100317 1101172 . + 0 ML0931 erg3 Membrane-bound C-5 sterol desaturase Erg3 (pseudogene) ML0931, len: 856 bp. Possible pseudogene of M. tuberculosis orthologue Rv1814|erg3 (903 bp) (Best blastx scores: 379). Yes lipid metabolism Rv1814 Rv1814 AL450380.2 Mycobrowser_v4 CDS 2251136 2251396 . - 0 ML1871c ML1871c Conserved hypothetical protein (pseudogene) ML1871c, len: 261 bp. Possible pseudogene of M. tuberculosis orthologue Rv0692 (330 bp) (Best blastx scores: 123). Yes conserved hypotheticals Rv0692 Rv0692 AL450380.2 Mycobrowser_v4 CDS 1110642 1110824 . + 0 ML0940 ML0940 Possible exported protein (pseudogene) ML0940, len: 183 bp. Possible pseudogene of M. tuberculosis orthologue Rv1115 (699 bp) (Best blastx scores: 139). Yes cell wall and cell processes Rv1115 Rv1115 AL450380.2 Mycobrowser_v4 CDS 1111225 1111513 . + 0 ML0941 ML0941 Conserved hypothetical protein (pseudogene) ML0941, len: 289 bp. Possible pseudogene of M. tuberculosis orthologue Rv1117 (324 bp) (Best blastx scores: 151) Yes conserved hypotheticals Rv1117 Rv1117 AL450380.2 Mycobrowser_v4 CDS 1112748 1114128 . + 0 ML0943 zwf1 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (pseudogene) ML0943, len: 1381 bp. Possible pseudogene of M. tuberculosis orthologue zwf1|Rv1121 (1401 bp) (Best blastx scores: 420). Yes intermediary metabolism and respiration Rv1121 Rv1121 AL450380.2 Mycobrowser_v4 CDS 1114163 1115172 . + 0 ML0944 gnd2 Probable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2 (pseudogene) ML0944, len: 1010 bp. Possible pseudogene of M. tuberculosis orthologue gnd2|Rv1122 (1023 bp) (Best blastx scores: 395). Yes intermediary metabolism and respiration Rv1122 Rv1122 AL450380.2 Mycobrowser_v4 CDS 1118092 1118540 . + 0 ML0948 ML0948 Hypothetical protein (pseudogene). ML0948, len: 449 bp. Possible pseudogene of a protein of unknown function from Streptomyces coelicolor Q9X7R8|AL049863. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1119352 1120284 . + 0 ML0951 ephC Probable epoxide hydrolase EphC (pseudogene) ML0951, len: 933 bp. Possible pseudogene of M. tuberculosis orthologue ephC|Rv1124 (951 bp) (Best blastx scores: 389). Yes virulence, detoxification, adaptation Rv1124 Rv1124 AL450380.2 Mycobrowser_v4 CDS 1120292 1121496 . + 0 ML0952 ML0952 Conserved hypothetical protein (pseudogene) ML0952, len: 1205 bp. Possible pseudogene of M. tuberculosis orthologue Rv1125 (1245 bp) (Best blastx scores: 383). Yes conserved hypotheticals Rv1125 Rv1125 AL450380.2 Mycobrowser_v4 CDS 1096067 1096435 . - 0 ML0926c ML0926c hypothetical protein ML0926c, len: 122 aa. Hypothetical unknown protein, weakly similar in parts to Y940_MYCTU|P71569|Rv0940c from Mycobacterium tuberculosis (288 aa), Fasta scores: E(): 0.0071, (30.4% identity in 112 aa overlap). Q9CCD7 No unknown Q9CCD7 AL450380.2 Mycobrowser_v4 CDS 1096527 1096835 . - 0 ML0927c ML0927c hypothetical protein ML0927c, len: 102 aa. Hypothetical unknown protein. Q9CCD6 No unknown Q9CCD6 AL450380.2 Mycobrowser_v4 CDS 1098056 1098340 . + 0 ML0928 ML0928 hypothetical protein ML0928, len: 94 aa. Hypothetical unknown protein. Q9CCD5 No unknown Q9CCD5 AL450380.2 Mycobrowser_v4 CDS 1109895 1110191 . + 0 ML0938 ML0938 hypothetical protein ML0938, len: 98 aa. Hypothetical unknown protein. Q9CCD4 No unknown Q9CCD4 AL450380.2 Mycobrowser_v4 CDS 1110188 1110430 . + 0 ML0939 ML0939 hypothetical protein ML0939, len: 80 aa. Hypothetical unknown protein. Q9CCD3 No unknown Q9CCD3 AL450380.2 Mycobrowser_v4 CDS 1106315 1106413 . - 0 ML0935c ML0935c Possible transposase remnant (pseudogene) ML0935c, len: 99 bp. Possible transposase remnant, similar to Q44454|Z18270 transposase from Agrobacterium tumefaciens (366 aa), (blastx scores: 90); and to Q9R9U9|AJ245436 transposase tnpa1 from Pseudomonas putida (355 aa), (blastx scores: 86). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1134799 1135292 . - 0 ML0966c ML0966c Conserved hypothetical membrane protein (pseudogene) ML0966c, len: 494 bp. Possible pseudogene of M. tuberculosis orthologue Rv1139c (501 bp) (Best blastx scores: 225). Yes cell wall and cell processes Rv1139c Rv1139c AL450380.2 Mycobrowser_v4 CDS 1135313 1136334 . - 0 ML0967c ML0967c Possible chalcone synthase (pseudogene) ML0967c, len: 1022 bp. Possible pseudogene similar to M. tuberculosis pks11|Rv1665 or pks10|Rv1660 (Best blastx scores: 288). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1136840 1137338 . + 0 ML0968 ML0968 Probable integral membrane protein (pseudogene) ML0968, len: 499 bp. Possible pseudogene of M. tuberculosis orthologue Rv1140 (849 bp) (Best blastx scores: 297). Yes cell wall and cell processes Rv1140 Rv1140 AL450380.2 Mycobrowser_v4 CDS 1137508 1138601 . + 0 ML0969 mcr Probable alpha-methylacyl-CoA racemase Mcr (pseudogene) ML0969, len: 1094 bp. Possible pseudogene of M. tuberculosis orthologue mcr|Rv1143 (1083 bp) (Best blastx scores: 1092) Yes lipid metabolism Rv1143 Rv1143 AL450380.2 Mycobrowser_v4 CDS 1138627 1139421 . + 0 ML0970 ML0970 Probable short-chain type dehydrogenase/reductase (pseudogene) ML0970, len: 795 bp. Possible pseudogene of M. tuberculosis orthologue Rv1144 (Best blastx scores: 282). Also similar to ML1746c a possible pseudogene similar to M. tuberculosis Rv1144. Yes intermediary metabolism and respiration Rv1144 Rv1144 AL450380.2 Mycobrowser_v4 CDS 1140056 1140909 . + 0 ML0971 mmpL13a Probable conserved transmembrane transport protein MmpL13a (pseudogene) ML0971, len: 854 bp. Possible pseudogene of M. tuberculosis orthologue Rv1145|mmpL13a (912 bp) (Best blastx scores: 305). Yes cell wall and cell processes Rv1145 Rv1145 AL450380.2 Mycobrowser_v4 CDS 1140950 1141217 . + 0 ML0972 mmpL13b Probable conserved transmembrane transport protein MmpL13b (pseudogene) ML0972, len: 268 bp. Possible pseudogene of M. tuberculosis orthologue Rv1146|mmpL13b (1413 bp) (Best blastx scores: 131). Yes cell wall and cell processes Rv1146 Rv1146 AL450380.2 Mycobrowser_v4 CDS 1141226 1141420 . + 0 ML0973 ML0973 Conserved hypothetical protein (pseudogene). ML0973, len: 195 bp. Possible pseudogene of M. tuberculosis orthologue Rv1147 (651 bp) (Best blastx scores: 202). Yes conserved hypotheticals Rv1147 Rv1147 AL450380.2 Mycobrowser_v4 CDS 1142462 1143289 . - 0 ML0974c ML0974c Conserved hypothetical protein (pseudogene) ML0974c, len: 828 bp. Possible pseudogene of M. tuberculosis orthologue Rv2751 (891 bp) (Best blastx scores: 348). Yes conserved hypotheticals Rv2751 Rv2751 AL450380.2 Mycobrowser_v4 CDS 1143310 1144162 . - 0 ML0975c ML0975c Probable dehydrogenase (pseudogene) ML0975c, len: 853 bp. Possible pseudogene of M. tuberculosis orthologue Rv2750 (819 bp) (Best blastx scores: 216). Yes intermediary metabolism and respiration Rv2750 Rv2750 AL450380.2 Mycobrowser_v4 CDS 1144203 1144445 . - 0 ML0976c ML0976c Conserved hypothetical protein (pseudogene) ML0976c, len: 243 bp. Possible pseudogene of M. tuberculosis orthologue Rv2749 (315 bp) (Best blastx scores: 131). Yes conserved hypotheticals Rv2749 Rv2749 AL450380.2 Mycobrowser_v4 CDS 1119158 1119358 . - 0 ML0950c ML0950c hypothetical protein ML0950c, len: 66 aa. Hypothetical unknown protein. Q9CCD0 No unknown Q9CCD0 AL450380.2 Mycobrowser_v4 CDS 1125857 1126231 . - 0 ML0957c ML0957c hypothetical protein ML0957c, len: 124 aa. Hypothetical unknown protein. Q9CCC7 No unknown Q9CCC7 AL450380.2 Mycobrowser_v4 CDS 1126242 1126673 . + 0 ML0958 ML0958 putative membrane protein ML0958, len: 143 aa. Possible membrane protein containing a membrane spanning hydrophobic domain. Q9CCC6 No cell wall and cell processes Q9CCC6 AL450380.2 Mycobrowser_v4 CDS 1126915 1127268 . + 0 ML0959 ML0959 hypothetical protein ML0959, len: 117 aa. Hypothetical unknown protein. Q9CCC5 No unknown Q9CCC5 AL450380.2 Mycobrowser_v4 CDS 1148471 1148754 . + 0 ML0980 ML0980 Possible transcriptional regulatory protein (pseudogene). ML0980, len: 284 bp. Possible pseudogene of M. tuberculosis orthologue Rv2745c (339 bp) (Best blastx scores: 74). Yes regulatory proteins Rv2745c Rv2745c AL450380.2 Mycobrowser_v4 CDS 1148894 1149722 . + 0 ML0981 35kd_ag Conserved 35 kDa ala-rich protein (pseudogene) ML0981, len: 829 bp. Possible pseudogene of M. tuberculosis orthologue 35kd_ag|Rv2744c (813 bp) (Best blastx scores: 624). Yes conserved hypotheticals Rv2744c Rv2744c AL450380.2 Mycobrowser_v4 CDS 1149757 1150605 . + 0 ML0982 ML0982 Possible conserved transmembrane alanine rich protein (pseudogene) ML0982, len: 849 bp. Possible pseudogene of M. tuberculosis orthologue Rv2743c (813 bp) (Best blastx scores: 792). Yes cell wall and cell processes Rv2743c Rv2743c AL450380.2 Mycobrowser_v4 CDS 1150703 1150913 . + 0 ML0983 ML0983 Conserved hypothetical arginine rich protein (pseudogene) ML0983, len: 211 bp. Possible pseudogene of M. tuberculosis orthologue Rv2742c (834 bp) (Best blastx scores: 144). Yes conserved hypotheticals Rv2742c Rv2742c AL450380.2 Mycobrowser_v4 CDS 1159849 1160082 . - 0 ML0992c ML0992c Probable transmembrane serine-threonine protein kinase (pseudogene) ML0992c, len: 234 bp. Possible pseudogene similar to M. tuberculosis pknE|Rv1743 (Best blastx scores: 104) also similar to pknH|Rv1266c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 811544 811819 . + 0 ML0675 ML0675 Probable integral membrane protein ML0675, len: 91 aa. Probable integral membrane protein highly similar to O50384|AL123456|Rv3355c Probable integral membrane protein from M. tuberculosis (97 aa), Fasta scores: E(): 1.2e-24, (77.9% identity in 95 aa overlap); and CAD95535|Mb3390c from M. bovis (97 aa). Also similar to O50377|Rv3346c Hypothetical protein from M. tuberculosis (85 aa), fasta scores: E(): 5.2e-18, (68.421% identity in 95 aa overlap). Previously sequenced as O32878|Z98271 (91 aa), Fasta scores: E(): 0, (98.9% identity in 91 aa overlap). Q7AQG3 No cell wall and cell processes Q7AQG3 Rv3355c Rv3355c AL450380.2 Mycobrowser_v4 CDS 863878 865226 . + 0 ML0721 lat Probable lysine-epsilon aminotransferase Lat (pseudogene) ML0721, len: 1349 bp. Possible pseudogene of M. tuberculosis orthologue lat|Rv3290c (1350 bp) (Best blastx scores: 509). Yes intermediary metabolism and respiration Rv3290c Rv3290c AL450380.2 Mycobrowser_v4 CDS 865372 865701 . + 0 ML0722 ML0722 Possible transmembrane protein (pseudogene) ML0722, len: 330 bp. Possible pseudogene of M. tuberculosis orthologue Rv3289c (378 bp) (Best blastx scores: 261). Yes cell wall and cell processes Rv3289c Rv3289c AL450380.2 Mycobrowser_v4 CDS 865726 866097 . + 0 ML0723 usfY Putative protein UsfY (pseudogene) ML0723, len: 372 bp. Possible pseudogene of M. tuberculosis orthologue Rv3288c|usfY (414 bp) (Best blastx scores: 210) Yes conserved hypotheticals Rv3288c Rv3288c AL450380.2 Mycobrowser_v4 CDS 866037 866822 . + 0 ML0724 rsbW Anti-sigma factor RsbW (pseudogene) ML0724, len: 786 bp. Possible pseudogene of M. tuberculosis orthologue rsbW|Rv3287c (438 bp) (Best blastx scores: 286). Yes information pathways Rv3287c Rv3287c AL450380.2 Mycobrowser_v4 CDS 866918 867686 . + 0 ML0725 sigF Alternate RNA polymerase sigma factor (ECF subfamily) SigF (pseudogene) ML0725, len: 769 bp. Possible pseudogene of M. tuberculosis orthologue sigF|Rv3286c (786 bp) (Best blastx scores: 406). Yes information pathways Rv3286c Rv3286c AL450380.2 Mycobrowser_v4 CDS 869613 870012 . - 0 ML0727c ML0727c Conserved hypothetical protein (pseudogene) ML0727c, len: 400 bp. Possible pseudogene of M. tuberculosis orthologue Rv3284 (432 bp) (Best blastx scores: 203). Yes conserved hypotheticals Rv3284 Rv3284 AL450380.2 Mycobrowser_v4 CDS 860657 861953 . - 0 ML0718c pcd Probable piperideine-6-carboxylic acid dehydrogenase Pcd (pseudogene) ML0718c, len: 1297 bp. Possible pseudogene of M. tuberculosis orthologue pcd|Rv3293 (1485 bp) (Best blastx scores: 421). Yes intermediary metabolism and respiration Rv3293 Rv3293 AL450380.2 Mycobrowser_v4 CDS 1011356 1011966 . - 0 ML0851c sirR Probable transcriptional repressor SirR (pseudogene) ML0851c, len: 611 bp. Possible pseudogene of M. tuberculosis orthologue sirR|Rv2788 (687 bp) (Best blastx scores: 192). Yes regulatory proteins Rv2788 Rv2788 AL450380.2 Mycobrowser_v4 CDS 1160769 1162378 . + 0 ML0993 ML0993 Probable conserved integral membrane alanine, valine and leucine rich protein (pseudogene) ML0993, len: 1610 bp. Possible pseudogene of M. tuberculosis orthologue Rv2729c (906 bp) (Best blastx scores: 226). Yes cell wall and cell processes Rv2729c Rv2729c AL450380.2 Mycobrowser_v4 CDS 899661 900353 . - 0 ML0757c ML0757c hypothetical protein ML0757c, len: 230 aa. Hypothetical protein, shows some similarity to Q8VJ42 Hypothetical protein MT3362 from M. tuberculosis CDC1551 (44 aa), fasta scores: E(): 0.00082, (77.419% identity in 31 aa overlap). Q9CCK3 No unknown Q9CCK3 AL450380.2 Mycobrowser_v4 CDS 1420022 1420336 . - 0 ML1203c glbN Probable hemoglobin GlbN (pseudogene) ML1203c, len: 315 bp. Possible pseudogene of M. tuberculosis orthologue glbN|Rv1542c (411 bp) (Best blastx scores: 104). Yes intermediary metabolism and respiration Rv1542c Rv1542c AL450380.2 Mycobrowser_v4 CDS 1131803 1132060 . + 0 ML0964 ML0964 hypothetical protein ML0964, len: 85 aa. Hypothetical unknown protein. Q9CCC3 No unknown Q9CCC3 AL450380.2 Mycobrowser_v4 CDS 1509242 1510184 . - 0 ML1266c ML1266c Membrane serine-threonine protein kinase (pseudogene) ML1266c, len: 943 bp. Possible pseudogene similar to M. tuberculosis pknF|Rv1746 (1431 bp) (Best blastx scores: 141) and similar to pknJ|Rv2088 and pknI|Rv2914c. Also similar to ML1386 a possible pseudogene similar to M. tuberculosis pknF. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1427779 1428215 . + 0 ML1208 ML1208 Conserved hypothetical protein (pseudogene) ML1208, len: 437 bp. Possible pseudogene of M. tuberculosis orthologue Rv1558 (447 bp) (Best blastx scores: 405). Yes conserved hypotheticals Rv1558 Rv1558 AL450380.2 Mycobrowser_v4 CDS 1181061 1181483 . - 0 ML1011c ML1011c hypothetical protein ML1011c, len: 140 aa. Hypothetical unknown protein. Q9CCB6 No unknown Q9CCB6 AL450380.2 Mycobrowser_v4 CDS 1235301 1235648 . - 0 ML1071c ML1071c Probable conserved integral membrane protein (pseudogene) ML1071c, len: 348 bp. Possible pseudogene of M. tuberculosis orthologue Rv1216c (675 bp) (Best blastx scores: 244). Yes cell wall and cell processes Rv1216c Rv1216c AL450380.2 Mycobrowser_v4 CDS 1530419 1531375 . - 0 ML1285c cya Membrane anchored adenylyl cyclase Cya (pseudogene) ML1285c, len: 957 bp. Possible pseudogene of M. tuberculosis orthologue Rv1625c|cya (1332 bp) (Best blastx scores: 272). Yes intermediary metabolism and respiration Rv1625c Rv1625c AL450380.2 Mycobrowser_v4 CDS 2012255 2012911 . + 0 ML1668A ML1668A Putative oxidoreductase (pseudogene) ML1668A, len: 657 bp. Possible pseudogene similar to several Putative oxidoreductases e.g. Q82M11 from Streptomyces avermitilis (278 aa) (Best blastx score: 173). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1383638 1384716 . - 0 ML1184c ML1184c Possible zinc-containing alcohol dehydrogenase nad dependent (pseudogene) ML1184c, len: 1079 bp. Possible pseudogene similar to M. tuberculosis paralogue adhB|Rv0761c (Best blastx scores: 217) and also similar to adhD|Rv3086. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1523865 1524236 . + 0 ML1280 ML1280 Short-chain alcohol dehydrogenase family (pseudogene) ML1280, len: 372 bp. Possible pseudogene similar to several M. tuberculosis short-chain alcohol dehydrogenases e.g. Rv0765c, Rv1865, Rv1050 and Rv3057 (Best blastx scores: 81). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1246220 1246770 . - 0 ML1083c ML1083c Conserved hypothetical protein (pseudogene) ML1083c, len: 551 bp. Possible pseudogene of M. tuberculosis orthologue Rv1232c (1308 bp) (Best blastx scores: 228). Yes conserved hypotheticals Rv1232c Rv1232c AL450380.2 Mycobrowser_v4 CDS 1285581 1286612 . + 0 ML1111 ML1111 Adenylate cyclase (pseudogene) ML1111, len: 1032 bp. Possible pseudogene of M. tuberculosis orthologue Rv1264 (1194 bp) (Best blastx scores: 409). Yes intermediary metabolism and respiration Rv1264 Rv1264 AL450380.2 Mycobrowser_v4 CDS 1374950 1375678 . + 0 ML1178 fabG2 Probable 3-oxoacyl-[ACP] reductase FabG2 (pseudogene) ML1178, len: 729 bp. Possible pseudogene of M. tuberculosis orthologue fabG2|Rv1350 (744 bp) (Best blastx scores: 176). Yes lipid metabolism Rv1350 Rv1350 AL450380.2 Mycobrowser_v4 CDS 2146521 2147343 . - 0 ML1771c ML1771c Hypothetical protein (pseudogene) ML1771c, len: 823 bp. Possible pseudogene of M. tuberculosis orthologue Rv2319c (879 bp) (Best blastx scores: 252). Yes virulence, detoxification, adaptation Rv2319c Rv2319c AL450380.2 Mycobrowser_v4 CDS 1377210 1378304 . + 0 ML1179 ML1179 Probable acyl-CoA dehydrogenase (pseudogene) ML1179, len: 1095 bp. Possible pseudogene similar to M. tuberculosis FadE3|Rv0215c (1074 bp) (Best blastx scores: 329). Also similar to ML2626c a possible pseudogene similar to M. tuberculosis fadE3. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1033728 1035173 . + 0 ML0870 ML0870 Conserved hypothetical protein (pseudogene) ML0870, len: 1446 bp. Possible pseudogene of M. tuberculosis orthologue Rv2205c (1077 bp) (Best blastx scores: 131) Yes conserved hypotheticals Rv2205c Rv2205c AL450380.2 Mycobrowser_v4 CDS 1528830 1530134 . - 0 ML1284c cydA Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA (pseudogene) ML1284c, len: 1305 bp. Possible pseudogene of M. tuberculosis orthologue cydA|Rv1623c (1458 bp) (Best blastx scores: 1184). Yes intermediary metabolism and respiration Rv1623c Rv1623c AL450380.2 Mycobrowser_v4 CDS 1349726 1350955 . - 0 ML1154c ML1154c Possible adenylate cyclase (pseudogene) ML1154c, len: 1230 bp. Possible pseudogene of M. tuberculosis orthologue Rv1318c (1626 bp) (Best blastx scores: 336) and similar to Rv1320c and Rv1319c. Also similar to ML0465 a possible pseudogene similar to M. tuberculosis Rv1318c. Yes intermediary metabolism and respiration Rv1318c Rv1318c AL450380.2 Mycobrowser_v4 CDS 1187213 1187428 . - 0 ML1018c ML1018c hypothetical protein ML1018c, len: 71 aa. Hypothetical unknown protein. Q9CCB3 No unknown Q9CCB3 AL450380.2 Mycobrowser_v4 CDS 1280429 1280770 . + 0 ML1106 ML1106 hypothetical protein ML1106, len: 113 aa. Hypothetical unknown protein. Q9CC90 No unknown Q9CC90 AL450380.2 Mycobrowser_v4 CDS 1338522 1338677 . - 0 ML1148c ML1148c hypothetical protein ML1148c, len: 51 aa. Hypothetical protein (doubtful CDS). Identical to the previously sequenced Q50137|U15186 Mycobacterium leprae (51 aa), Fasta scores: E(): 4.9e-22, 100.0% identity in 51 aa overlap. Q7AQ91 No unknown Q7AQ91 AL450380.2 Mycobrowser_v4 CDS 1111591 1112383 . - 0 ML0942c ML0942c Conserved hypothetical protein (pseudogene) ML0942c, len: 793 bp. Possible pseudogene of M. tuberculosis orthologue Rv1118c (861 bp) (Best blastx scores: 257). Yes conserved hypotheticals Rv1118c Rv1118c AL450380.2 Mycobrowser_v4 CDS 1048645 1050391 . - 0 ML0884c ML0884c Conserved hypothetical protein (pseudogene) ML0884c, len: 1747 bp. Possible pseudogene of M. tuberculosis orthologue Rv2191 (1938 bp) (Best blastx scores: 194). Yes information pathways Rv2191 Rv2191 AL450380.2 Mycobrowser_v4 CDS 1060121 1060874 . + 0 ML0894 ML0894 Probable conserved integral membrane protein (pseudogene) ML0894, len: 754 bp. Possible pseudogene of M. tuberculosis orthologue Rv2180c (888 bp) (Best blastx scores: 217). Yes cell wall and cell processes Rv2180c Rv2180c AL450380.2 Mycobrowser_v4 CDS 1177752 1178395 . - 0 ML1007c ML1007c Conserved hypothetical protein (pseudogene) ML1007c, len: 644 bp. Possible pseudogene of M. tuberculosis orthologue Rv2716 (687 bp) (Best blastx scores: 190). Yes conserved hypotheticals Rv2716 Rv2716 AL450380.2 Mycobrowser_v4 CDS 1196611 1196937 . + 0 ML1031 ML1031 Conserved hypothetical protein (pseudogene) ML1031, len: 327 bp. Possible pseudogene of M. tuberculosis orthologue Rv2694c (369 bp) (Best blastx scores: 124). Yes conserved hypotheticals Rv2694c Rv2694c AL450380.2 Mycobrowser_v4 CDS 1197738 1198012 . - 0 ML1033c ceoC TRK system potassium uptake protein CeoC (pseudogene) ML1033c, len: 275 bp. Possible pseudogene of M. tuberculosis orthologue ceoC|Rv2692 (663 bp) (Best blastx scores: 154). Yes cell wall and cell processes Rv2692 Rv2692 AL450380.2 Mycobrowser_v4 CDS 1211369 1212075 . + 0 ML1046 ML1046 Conserved hypothetical protein (pseudogene) ML1046, len: 707 bp. Possible pseudogene of M. tuberculosis orthologue Rv2675c (753 bp) (Best blastx scores: 246). Yes conserved hypotheticals Rv2675c Rv2675c AL450380.2 Mycobrowser_v4 CDS 1287173 1287433 . + 0 ML1112 ML1112 Hypothetical protein (pseudogene) ML1112, len: 261 bp. Possible pseudogene of M. tuberculosis orthologue Rv1265 (681 bp) (Best blastx scores: 242). Yes conserved hypotheticals Rv1265 Rv1265 AL450380.2 Mycobrowser_v4 CDS 1293284 1294515 . - 0 ML1118c ML1118c REP13E12-family protein (pseudogene) ML1118c, len: 1232 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins in REP13E12 degenerate repeat e.g. Rv1128c, Rv1702c, Rv1945 and Rv1148 (Best blastx scores: 268). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1833937 1834663 . + 0 ML1520 ML1520 Probable alanine rich hydrolase (pseudogene) ML1520, len: 727 bp. Possible pseudogene of M. tuberculosis orthologue Rv2765 (738 bp) (Best blastx scores: 188). Yes intermediary metabolism and respiration Rv2765 Rv2765 AL450380.2 Mycobrowser_v4 CDS 1180779 1181021 . - 0 ML1010c ML1010c hypothetical protein ML1010c, len: 80 aa. Hypothetical unknown protein. Q9CCB7 No unknown Q9CCB7 AL450380.2 Mycobrowser_v4 CDS 1222252 1222605 . + 0 ML1057 ML1057 hypothetical protein ML1057, len: 117 aa. Hypothetical unknown protein. Identical to the previously sequenced Q49947|U15180 M. leprae hypothetical protein (117 aa), Fasta scores: E(): 0, 99.1% identity in 117 aa overlap. Q7AQA0 No unknown Q7AQA0 AL450380.2 Mycobrowser_v4 CDS 1292712 1293197 . - 0 ML1117c ML1117c conserved hypothetical protein ML1117c, len: 161 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis Rv1276c SW:YC76_MYCTU (Q11043) (158 aa), Fasta scores: E(): 0, 65.4% identity in 162 aa overlap. Q9CC85 No conserved hypotheticals PF00300 Q9CC85 GO:0016787 3.1.3.- Rv1276c Rv1276c AL450380.2 Mycobrowser_v4 CDS 1198010 1198485 . + 0 ML1034 ML1034 Probable antibiotic-transport integral membrane leucine and valine rich protein ABC transporter (pseudogene) ML1034, len: 476 bp. Possible pseudogene of M. tuberculosis orthologue Rv2687c (714 bp) (Best blastx scores: 207). Yes cell wall and cell processes Rv2687c Rv2687c AL450380.2 Mycobrowser_v4 CDS 2431237 2431879 . - 0 ML2040c ML2040c Hypothetical protein (pseudogene) ML2040c, len: 643 bp. Possible pseudogene of M. tuberculosis orthologue Rv1874 (687 bp) (Best blastx scores: 169). Yes conserved hypotheticals Rv1874 Rv1874 AL450380.2 Mycobrowser_v4 CDS 1198513 1199223 . + 0 ML1035 ML1035 Probable antibiotic-transport integral membrane leucine, alanine and valine rich protein ABC transporter (pseudogene) ML1035, len: 711 bp. Possible pseudogene of M. tuberculosis orthologue Rv2686c (759 bp) (Best blastx scores: 229). Yes cell wall and cell processes Rv2686c Rv2686c AL450380.2 Mycobrowser_v4 CDS 1203552 1205229 . + 0 ML1039 ML1039 Possible oxidoreductase (pseudogene) ML1039, len: 1678 bp. Possible pseudogene similar to M. tuberculosis Rv3727 (1809 bp) (Best blastx scores: 386). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1207292 1208090 . - 0 ML1042c echA15 Probable enoyl-CoA hydratase EchA15 (pseudogene) ML1042c, len: 799 bp. Possible pseudogene of M. tuberculosis orthologue echA15|Rv2679 (831 bp) (Best blastx scores: 306). Yes lipid metabolism Rv2679 Rv2679 AL450380.2 Mycobrowser_v4 CDS 2252264 2252744 . + 0 ML1873 ML1873 Conserved hypothetical protein (pseudogene) ML1873, len: 481 bp. Possible pseudogene of M. tuberculosis orthologue Rv0690c (1050 bp) (Best blastx scores: 169). Yes conserved hypotheticals Rv0690c Rv0690c AL450380.2 Mycobrowser_v4 CDS 2286658 2287540 . + 0 ML1902 mmaA3 Methoxy mycolic acid synthase 3 MmaA3 (pseudogene) ML1902, len: 883 bp. Possible pseudogene of M. tuberculosis orthologue mmaA3|Rv0643c (882 bp) (Best blastx scores: 295). Yes lipid metabolism Rv0643c Rv0643c AL450380.2 Mycobrowser_v4 CDS 1265107 1266380 . + 0 ML1097 ML1097 Probable drug-transport integral membrane protein (pseudogene) ML1097, len: 1274 bp. Possible pseudogene of M. tuberculosis orthologue Rv1250 (1740 bp) (Best blastx scores: 225). Yes cell wall and cell processes Rv1250 Rv1250 AL450380.2 Mycobrowser_v4 CDS 1271266 1272635 . + 0 ML1100 deaD Probable cold-shock DEAD-box protein A homolog DeaD (pseudogene) ML1100, len: 1370 bp. Possible pseudogene of M. tuberculosis orthologue deaD|Rv1253 (1692 bp) (Best blastx scores: 769). Yes information pathways Rv1253 Rv1253 AL450380.2 Mycobrowser_v4 CDS 1035618 1036259 . - 0 ML0872c ML0872c POSSIBLE CONSERVED MEMBRANE PROTEIN ML0872c, len: 213 aa. Possible conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical 24.4 kDa protein Rv2203 or MYCY190.14 SW:YM03_MYCTU (Q10392) (230 aa) fasta scores: E(): 0, 61.7% identity in 230 aa. Contains hydrophobic, possible membrane-spanning region. Start changed since first submission protein now longer Q9CCF4 No cell wall and cell processes Q9CCF4 Rv2203 Rv2203 AL450380.2 Mycobrowser_v4 CDS 1004962 1005483 . - 0 ML0846c ML0846c Probable conserved transmembrane ATP-binding protein ABC transporter (pseudogene) ML0846c, len: 522 bp. Possible pseudogene similar to M. tuberculosis Rv1747 (2598 bp) (Best blastx scores: 127). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2236227 2237470 . - 0 ML1853c atsA Possible arylsulfatase AtsA (pseudogene) ML1853c, len: 1244 bp. Possible pseudogene of M. tuberculosis orthologue atsA|Rv0711 (2364 bp) (Best blastx scores: 344). Yes intermediary metabolism and respiration Rv0711 Rv0711 AL450380.2 Mycobrowser_v4 CDS 1275357 1276453 . - 0 ML1102c cyp130 Probable cytochrome P450 Cyp130 (pseudogene) ML1102c, len: 1097 bp. Possible pseudogene of M. tuberculosis orthologue cyp130|Rv1256c (1218 bp) (Best blastx scores: 356). Yes intermediary metabolism and respiration Rv1256c Rv1256c AL450380.2 Mycobrowser_v4 CDS 1277827 1278922 . - 0 ML1104c ML1104c Probable conserved integral membrane transport protein (pseudogene) ML1104c, len: 1096 bp. Possible pseudogene of M. tuberculosis orthologue Rv1258c (1260 bp) (Best blastx scores: 234). Yes cell wall and cell processes Rv1258c Rv1258c AL450380.2 Mycobrowser_v4 CDS 1280741 1281177 . - 0 ML1107c ML1107c Hypothetical HIT-like protein (pseudogene) ML1107c, len: 437 bp. Possible pseudogene of M. tuberculosis orthologue Rv1262c (435 bp) (Best blastx scores: 270). Yes conserved hypotheticals Rv1262c Rv1262c AL450380.2 Mycobrowser_v4 CDS 1282284 1283494 . + 0 ML1109 amiB2 Probable amidase AmiB2 (pseudogene) ML1109, len: 1211 bp. Possible pseudogene of M. tuberculosis orthologue amiB2|Rv1263 (1389 bp) (Best blastx scores: 454). Yes intermediary metabolism and respiration Rv1263 Rv1263 AL450380.2 Mycobrowser_v4 CDS 2298478 2298822 . + 0 ML1915 ML1915 hypothetical protein ML1915, len: 114 aa. Hypothetical unknown protein. Q9CBJ3 No unknown Q9CBJ3 AL450380.2 Mycobrowser_v4 CDS 2147420 2148621 . - 0 ML1772c rocE Probable cationic amino acid transport integral membrane protein RocE (pseudogene) ML1772c, len: 1202 bp. Possible pseudogene of M. tuberculosis orthologue rocE|Rv2320c (1431 bp) (Best blastx scores: 518). Yes cell wall and cell processes Rv2320c Rv2320c AL450380.2 Mycobrowser_v4 CDS 2148760 2149231 . - 0 ML1773c rocD2 Probable ornithine aminotransferase RocD2 (pseudogene) ML1773c, len: 472 bp. Possible pseudogene of M. tuberculosis orthologue rocD2|Rv2321c (546 bp) (Best blastx scores: 246). Yes intermediary metabolism and respiration Rv2321c Rv2321c AL450380.2 Mycobrowser_v4 CDS 2149256 2149876 . - 0 ML1774c rocD1 Probable ornithine aminotransferase RocD1 (pseudogene) ML1774c, len: 621 bp. Possible pseudogene of M. tuberculosis orthologue rocD1|Rv2322c (666 bp) (Best blastx scores: 214). Yes intermediary metabolism and respiration Rv2322c Rv2322c AL450380.2 Mycobrowser_v4 CDS 2149927 2150544 . - 0 ML1775c ML1775c Conserved hypothetical protein (pseudogene) ML1775c, len: 618 bp. Possible pseudogene of M. tuberculosis orthologue Rv2323c (909 bp) (Best blastx scores: 122). Yes conserved hypotheticals Rv2323c Rv2323c AL450380.2 Mycobrowser_v4 CDS 2150636 2151084 . + 0 ML1776 ML1776 Probable transcriptional regulatory protein (Lrp/AsnC family) (pseudogene) ML1776, len: 449 bp. Possible pseudogene of M. tuberculosis orthologue Rv2324 (447 bp) (Best blastx scores: 201). Yes regulatory proteins Rv2324 Rv2324 AL450380.2 Mycobrowser_v4 CDS 967175 968068 . + 0 ML0818 ML0818 conserved hypothetical protein ML0818, len: 297 aa. Conserved hypothetical protein. Similar to Rv3205c|O05861|AL123456 M. tuberculosis conserved hypothetical protein (292 aa), Fasta scores: E(): 0, 87.3% identity in 291 aa overlap. Q9CCG7 No conserved hypotheticals Q9CCG7 Rv3205c Rv3205c AL450380.2 Mycobrowser_v4 CDS 1679218 1680192 . + 0 ML1399 ML1399 conserved hypothetical protein ML1399, len: 324 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1647 TR:P94982 (EMBL:Z85982) (316 aa), Fasta scores: E(): 0, 74.0% identity in 312 aa overlap. Q9CC18 No conserved hypotheticals, intermediary metabolism and respiration PF00211 Q9CC18 GO:0007242,GO:0016849,GO:0009190 Rv1647 Rv1647 AL450380.2 Mycobrowser_v4 CDS 1840015 1840470 . - 0 ML1525c ML1525c conserved hypothetical protein ML1525c, len: 151 aa. Conserved hypothetical protein. Similar to hypothetical proteins from Streptomyces coelicolor TR:Q9RD46 (EMBL:AL133424) (151 aa), Fasta scores: E(): 1.3e-28, 56.1% identity in 148 aa overlap and Mycobacterium tuberculosis Rv2771c TR:O33313 (EMBL:AL008967) (150 aa), Fasta scores: E(): 2.2e-26, 52.7% identity in 148 aa overlap. Q9CBV8 No conserved hypotheticals Q9CBV8 Rv2771c Rv2771c AL450380.2 Mycobrowser_v4 CDS 2829422 2831174 . + 0 ML2364 ML2364 Possible hydrolase (pseudogene) ML2364, len: 1753 bp. Possible pseudogene of M. tuberculosis orthologue Rv3762c (1881 bp) (Best blastx scores: 368). Yes intermediary metabolism and respiration Rv3762c Rv3762c AL450380.2 Mycobrowser_v4 CDS 2833554 2834580 . + 0 ML2365 fadE36 Possible acyl-CoA dehydrogenase FadE36 (pseudogene) ML2365, len: 1027 bp. Possible pseudogene of M. tuberculosis orthologue fadE36|Rv3761c (1056 bp) (Best blastx scores: 427). Yes lipid metabolism Rv3761c Rv3761c AL450380.2 Mycobrowser_v4 CDS 1988391 1989203 . - 0 ML1650c ML1650c Hypothetical protein (pseudogene) ML1650c, len: 813 bp. Possible pseudogene of M. tuberculosis orthologue Rv2240c (Best blastx scores: 203). Yes conserved hypotheticals Rv2240c Rv2240c AL450380.2 Mycobrowser_v4 CDS 2873825 2875117 . + 0 ML2403 ML2403 Conserved hypothetical protein (pseudogene) ML2403, len: 1293 bp. Possible pseudogene of M. tuberculosis orthologue Rv1069c (1764 bp) (Best blastx scores: 333). Yes conserved hypotheticals Rv1069c Rv1069c AL450380.2 Mycobrowser_v4 CDS 1931213 1931413 . + 0 ML1605 ML1605 hypothetical protein ML1605, len: 66 aa. Hypothetical unknown protein. Q9CBT6 No unknown Q9CBT6 AL450380.2 Mycobrowser_v4 CDS 2363941 2364348 . - 0 ML1979c ML1979c hypothetical protein ML1979c, len: 135 aa. Hypothetical unknown protein. Q9CBH3 No unknown Q9CBH3 AL450380.2 Mycobrowser_v4 CDS 1909596 1909850 . + 0 ML1584 ML1584 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN ML1584, len: 84 aa. Possible conserved transmembrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2876 SW:YS76_MYCTU (Q10802) (104 aa), Fasta scores: E(): 3.3e-26, 75.0% identity in 88 aa overlap. Contains possible membrane spanning hydrophobic domains. Q9CBU2 No cell wall and cell processes Q9CBU2 GO:0005886,GO:0016021 Rv2876 Rv2876 AL450380.2 Mycobrowser_v4 CDS 1949524 1951565 . - 0 ML1625c glnD Probable uridylyltransferase GlnD (pseudogene) ML1625c, len: 2042 bp. Possible pseudogene of M. tuberculosis orthologue glnD|Rv2918c (2427 bp) (Best blastx scores: 428). Yes intermediary metabolism and respiration Rv2918c Rv2918c AL450380.2 Mycobrowser_v4 CDS 1951869 1952203 . - 0 ML1626c glnB Probable nitrogen regulatory protein GlnB (pseudogene) ML1626c, len: 335 bp. Possible pseudogene of M. tuberculosis orthologue glnB|Rv2919c (339 bp) (Best blastx scores: 227). Yes regulatory proteins Rv2919c Rv2919c AL450380.2 Mycobrowser_v4 CDS 2055050 2055748 . + 0 ML1704 ML1704 conserved hypothetical protein ML1704, len: 232 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv3013 TR:O53260 (EMBL:AL021287) (218 aa), Fasta scores: E(): 0, 84.3% identity in 216 aa overlap. Q9CBR7 No conserved hypotheticals PF01842 Q9CBR7 GO:0008152,GO:0016597 Rv3013 Rv3013 AL450380.2 Mycobrowser_v4 CDS 1926761 1927126 . - 0 ML1601c ML1601c hypothetical protein ML1601c, len: 121 aa. Hypothetical unknown protein. Q7AQ39 No unknown Q7AQ39 AL450380.2 Mycobrowser_v4 CDS 2200636 2201457 . - 0 ML1817c ML1817c Possible enoyl-CoA hydratase EchA12 (pseudogene) ML1817c, len: 822 bp. Possible pseudogene similar to M. tuberculosis echA12|Rv1472 (858 bp) (Best blastx scores: 581), also similar to ML1241 a possible orthologue of M. tuberculosis echA12 . Yes lipid metabolism Rv1472 Rv1472 AL450380.2 Mycobrowser_v4 CDS 2207111 2208633 . - 0 ML1823c ML1823c Putative transposase (pseudogene) ML1823c, len: 1523 bp. Possible pseudogene similar to M. smegmatis putative IS1549 transposase (1509 bp) (Best blastx scores: 393). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2372747 2373198 . - 0 ML1986c ML1986c Probable RNA polymerase sigma factor, ECF subfamily (pseudogene) ML1986c, len: 452 bp. Possible pseudogene similar to M. tuberculosis sigC|Rv2069 (558 bp) (Best blastx scores: 104). Also similar to ML1448 a possible orthologue of M. tuberculosis sigC. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2393663 2394285 . - 0 ML2001c ML2001c Conserved hypothetical protein (pseudogene) ML2001c, len: 623 bp. Possible pseudogene of M. tuberculosis orthologue Rv1913 (753 bp) (Best blastx scores: 204). Yes conserved hypotheticals Rv1913 Rv1913 AL450380.2 Mycobrowser_v4 CDS 2430745 2431199 . - 0 ML2039c ML2039c Conserved hypothetical protein (pseudogene) ML2039c, len: 455 bp. Possible pseudogene of M. tuberculosis orthologue Rv1875 (444 bp) (Best blastx scores: 120). Yes conserved hypotheticals Rv1875 Rv1875 AL450380.2 Mycobrowser_v4 CDS 2533963 2535008 . + 0 ML2132 citA Probable citrate synthase II CitA (pseudogene) ML2132, len: 1046 bp. Possible pseudogene of M. tuberculosis orthologue citA|Rv0889c (1122 bp) (Best blastx scores: 650). Yes intermediary metabolism and respiration Rv0889c Rv0889c AL450380.2 Mycobrowser_v4 CDS 2685660 2686473 . - 0 ML2262c ML2262c Possible oxidoreductase (pseudogene) ML2262c, len: 814 bp. Possible pseudogene of M. tuberculosis orthologue Rv0547c (885 bp) (Best blastx scores: 587). Yes intermediary metabolism and respiration Rv0547c Rv0547c AL450380.2 Mycobrowser_v4 CDS 2745528 2745656 . - 0 ML2318c ML2318c Conserved hypothetical protein (pseudogene) ML2318c, len: 129 bp. Possible pseudogene of M. tuberculosis orthologue Rv3703c (1278 bp) (Best blastx scores: 169). Yes conserved hypotheticals Rv3703c Rv3703c AL450380.2 Mycobrowser_v4 CDS 2756639 2757602 . - 0 ML2325c dnaQ Probable DNA polymerase III (epsilon chain) DnaQ (pseudogene) ML2325c, len: 964 bp. Possible pseudogene of M. tuberculosis orthologue dnaQ|Rv3711c (990 bp) (Best blastx scores: 453). Yes information pathways Rv3711c Rv3711c AL450380.2 Mycobrowser_v4 CDS 2775372 2778525 . + 0 ML2340 ML2340 Probable conserved two-domain membrane protein (pseudogene) ML2340, len: 3154 bp. Possible pseudogene of M. tuberculosis orthologue Rv3728 (3198 bp) (Best blastx scores: 386). Yes cell wall and cell processes Rv3728 Rv3728 AL450380.2 Mycobrowser_v4 CDS 2841568 2842047 . - 0 ML2373c ML2373c Conserved hypothetical protein (pseudogene) ML2373c, len: 480 bp. Possible pseudogene of M. tuberculosis orthologue Rv0448c (666 bp) (Best blastx scores: 183). Yes conserved hypotheticals Rv0448c Rv0448c AL450380.2 Mycobrowser_v4 CDS 2153068 2154499 . - 0 ML1777c glpD1 Probable glycerol-3-phosphate dehydrogenase GlpD1 (pseudogene) ML1777c, len: 1432 bp. Possible pseudogene of M. tuberculosis orthologue glpD1|Rv2249c (1551 bp) (Best blastx scores: 420). Yes intermediary metabolism and respiration Rv2249c Rv2249c AL450380.2 Mycobrowser_v4 CDS 2233459 2234455 . - 0 ML1850c ML1850c Conserved 13E12 repeat family protein (pseudogene) ML1850c, len: 997 bp. Possible pseudogene similar to M. tuberculosis 13E12 repeat family e.g. Rv0336 or Rv0515 (Best blastx scores: 237), similar to M. leprae ML1290 pseudogene. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2309713 2310733 . - 0 ML1924c ML1924c Conserved hypothetical protein (pseudogene) ML1924c, len: 1021 bp. Possible pseudogene of M. tuberculosis orthologue Rv0433 (1131 bp) (Best blastx scores: 802). Yes conserved hypotheticals Rv0433 Rv0433 AL450380.2 Mycobrowser_v4 CDS 2745752 2746966 . - 0 ML2319c gshA Possible glutamate--cysteine ligase GshA (pseudogene) ML2319c, len: 1215 bp. Possible pseudogene of M. tuberculosis orthologue gshA|Rv3704c (1299 bp) (Best blastx scores: 360). Yes intermediary metabolism and respiration Rv3704c Rv3704c AL450380.2 Mycobrowser_v4 CDS 1933739 1934811 . - 0 ML1609c fdhF Possible formate dehydrogenase FdhF (pseudogene) ML1609c, len: 1073 bp. Possible pseudogene of M. tuberculosis orthologue fdhF|Rv2900c (2340 bp) (Best blastx scores: 351). Yes intermediary metabolism and respiration Rv2900c Rv2900c AL450380.2 Mycobrowser_v4 CDS 2039929 2041173 . + 0 ML1693 ML1693 Possible alanine rich dehydrogenase (pseudogene) ML1693, len: 1245 bp. Possible pseudogene of M. tuberculosis orthologue Rv2997 (1443 bp) (Best blastx scores: 314). Yes intermediary metabolism and respiration Rv2997 Rv2997 AL450380.2 Mycobrowser_v4 CDS 1967676 1968964 . - 0 ML1634c ML1634c Conserved hypothetical protein (pseudogene) ML1634c, len: 1289 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins e.g. Rv1760, Rv0895 and Rv1425 (Best blastx scores: 229). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2912936 2914369 . + 0 ML2438 ML2438 Probable oxidoreductase GMC type (pseudogene) ML2438, len: 1434 bp. Possible pseudogene of M. tuberculosis orthologue Rv0492c (1890 bp) (Best blastx scores: 274). Yes intermediary metabolism and respiration Rv0492c Rv0492c AL450380.2 Mycobrowser_v4 CDS 3076868 3077081 . - 0 ML2577c ML2577c Conserved hypothetical protein (pseudogene) ML2577c, len: 214 bp. Possible pseudogene of M. tuberculosis orthologue Rv1103c (321 bp) (Best blastx scores: 91). Yes virulence, detoxification, adaptation Rv1103c Rv1103c AL450380.2 Mycobrowser_v4 CDS 2070057 2071120 . + 0 ML1716 ML1716 Probable membrane protein (pseudogene) ML1716, len: 1064 bp. Possible pseudogene similar to M. tuberculosis Rv1490 (1308 bp) (Best blastx scores: 164). Yes unknown AL450380.2 Mycobrowser_v4 CDS 358834 359277 . - 0 ML0276c ML0276c Conserved hypothetical protein ML0276c, len: 147 aa. Conserved hypothetical protein, highly similar to Rv0390|P95198|AL123456 conserved hypothetical protein from M. tuberculosis (140 aa), Fasta scores: E(): 0, (79.0% identity in 138 aa overlap). Also similar to other bacterial hypothetical proteins e.g. Q9ZCV8|AJ235272 RP600, hypothetical protein from Rickettsia prowazekii (123 aa), Fasta scores: E(): 8.6e-05, (35.1% identity in 134 aa overlap). Previously sequenced as O69593|AL023514 (147 aa), Fasta scores: E(): 0, (100.0% identity in 147 aa overlap). Q7AQK6 No conserved hypotheticals Q7AQK6 Rv0390 Rv0390 AL450380.2 Mycobrowser_v4 CDS 380011 380147 . + 0 ML0296 ML0296 Conserved hypothetical protein (pseudogene) ML0296, len: 137 bp. Possible pseudogene of M. tuberculosis orthologue Rv0421c (630 bp) (Best blastx scores: 85). Yes conserved hypotheticals Rv0421c Rv0421c AL450380.2 Mycobrowser_v4 CDS 383529 384154 . - 0 ML0301c mutT3 Possible mutator protein MutT3 (pseudogene) ML0301c, len: 626 bp. Possible pseudogene of M. tuberculosis orthologue mutT3|Rv0413 (654 bp) (Best blastx scores: 180). Yes information pathways Rv0413 Rv0413 AL450380.2 Mycobrowser_v4 CDS 372034 372426 . - 0 ML0291c ML0291c Hypothetical protein ML0291c, len: 130 aa. Hypothetical unknown function. Previously sequenced as O69603|AL023514 (130 aa), Fasta scores: E(): 0, (99.2% identity in 130 aa overlap). Q7AQK1 No unknown Q7AQK1 AL450380.2 Mycobrowser_v4 CDS 373605 373844 . - 0 ML0292c ML0292c Hypothetical protein ML0292c, len: 79 aa. Hypothetical unknown function. Possibly the remains of a disrupted gene. Q9CCX2 No unknown Q9CCX2 AL450380.2 Mycobrowser_v4 CDS 375453 375662 . - 0 ML0293c ML0293c Hypothetical protein ML0293c, len: 69 aa. Hypothetical unknown function. Possibly the remains of a disrupted gene. Q9CCX1 No unknown Q9CCX1 AL450380.2 Mycobrowser_v4 CDS 414866 415129 . + 0 ML0325 ML0325 hypothetical protein ML0325, len: 87 aa. hypothetical protein. Possibly the remains of a disrupted gene. Q9CCW3 No unknown Q9CCW3 AL450380.2 Mycobrowser_v4 CDS 2071291 2071638 . + 0 ML1717 ML1717 Hypothetical protein (pseudogene) ML1717, len: 348 bp. Possible pseudogene similar to Q8VJ84 Hypothetical protein MT3117 from M. tuberculosis CDC1551 (387 bp) (best blastx score: 260). Q9CBR2 Yes unknown Q9CBR2 AL450380.2 Mycobrowser_v4 CDS 2081624 2082464 . - 0 ML1725c ML1725c Conserved hypothetical protein (pseudogene) ML1725c, len: 841 bp. Possible pseudogene of M. tuberculosis orthologue Rv3040c (867 bp) (Best blastx scores: 838). Yes conserved hypotheticals Rv3040c Rv3040c AL450380.2 Mycobrowser_v4 CDS 369817 370960 . + 0 ML0289 ML0289 Putative group II intron maturase-related protein (pseudogene) ML0289, len: 1144 bp. Possible pseudogene, similar to several maturases e.g. Q9MD87|AF218567 putative maturase from Cryphonectria parasitica (Cheshnut blight fungus) (2334 bp, (blastx scores: 143); and Rv0071|O53616 Putative maturase from M. tuberculosis (705 bp), (blastx scores: 153). Belongs to the LEPREP family of dispersed repeats (see citation below) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2154522 2155160 . - 0 ML1778c ML1778c Possible transcriptional regulatory protein (pseudogene) ML1778c, len: 639 bp. Possible pseudogene of M. tuberculosis orthologue Rv2250c (570 bp) (Best blastx scores: 307). Yes regulatory proteins Rv2250c Rv2250c AL450380.2 Mycobrowser_v4 CDS 2155439 2156725 . + 0 ML1779 ML1779 Possible flavoprotein (pseudogene) ML1779, len: 1287 bp. Possible pseudogene of M. tuberculosis orthologue Rv2251 (1428 bp) (Best blastx scores: 327) Yes intermediary metabolism and respiration Rv2251 Rv2251 AL450380.2 Mycobrowser_v4 CDS 2136034 2136378 . - 0 ML1761c ML1761c hypothetical protein ML1761c, len: 114 aa. Hypothetical unknown protein. Q9CBP0 No unknown Q9CBP0 AL450380.2 Mycobrowser_v4 CDS 2105023 2105675 . - 0 ML1744c ML1744c Probable transcriptional regulatory protein (GntR family) (pseudogene) ML1744c, len: 653 bp. Possible pseudogene of M. tuberculosis orthologue Rv3060c (1473 bp) (Best blastx scores: 270). Yes regulatory proteins Rv3060c Rv3060c AL450380.2 Mycobrowser_v4 CDS 1987392 1987836 . - 0 ML1648c ahpE Probable peroxiredoxin AhpE (pseudogene) ML1648c, len: 445 bp. Possible pseudogene of M. tuberculosis orthologue ahpE|Rv2238c (462 bp) (Best blastx scores: 175). Yes virulence, detoxification, adaptation Rv2238c Rv2238c AL450380.2 Mycobrowser_v4 CDS 371225 371323 . + 0 ML0290 ML0290 Possible transposase remnant (pseudogene) ML0290, len: 99 bp. Possible transposase remnant, similar to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 93); and to Q9R9U9|AJ245436 transposase tnpa1 from Pseudomonas putida (1065 bp), (blastx scores: 89). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 tRNA 2594585 2594661 . - 0 MLP000039 pheU tRNA-Phe anticodon GAA tRNA Phe anticodon GAA, Cove scores: 79.14 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2594797 2594869 . - 0 MLP000041 gluT tRNA-Glu anticodon TTC tRNA Glu anticodon TTC, Cove scores: 65.04 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2594993 2595065 . + 0 MLP000042 lysT tRNA-Lys anticodon TTT tRNA Lys anticodon TTT, Cove scores: 79.95 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 109049 109822 . + 0 ML0087 ML0087 Possible acyltransferase ML0087, len: 257 aa. Possible acyltransferase (EC 2.3.1.-), highly similar to Rv3816c|O07807|AL123456 possible acyltransferase from M. tuberculosis (259 aa), Fasta scores: E(): 0, (81.5% identity in 254 aa overlap). Also similar to the neighboring putative acyltransferases in M. tuberculosis, Rv3815c and Rv3814c. Also similar to ML0892. Shows similarity to many putative bacterial acyltransferases. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. Q9CDC0 No intermediary metabolism and respiration PF01553 Q9CDC0 GO:0008152,GO:0008415 Rv3816c Rv3816c AL450380.2 Mycobrowser_v4 CDS 133849 135036 . - 0 ML0103c fadE35 Probable acyl-CoA dehydrogenase FadE35 (pseudogene) ML0103c, len: 1188 bp. Possible pseudogene of M. tuberculosis orthologue fadE35|Rv3797 (1782 bp) (Best blastx scores: 159) Yes lipid metabolism Rv3797 Rv3797 AL450380.2 Mycobrowser_v4 tRNA 990847 990919 . + 0 MLP000014 asnT tRNA-Asn anticodon GTT tRNA Asn anticodon GTT, Cove scores: 78.91 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 341956 342250 . - 0 ML0262c esxJ Putative ESAT-6 like protein EsxJ (pseudogene) ML0262c, len: 295 bp. Probable pseudogene of M. tuberculosis orthologue Rv1038c (297 bp) (Best blastx scores: 310) Yes cell wall and cell processes Rv1038c Rv1038c AL450380.2 Mycobrowser_v4 CDS 390458 391902 . - 0 ML0305c ML0305c Possible integral membrane protein (pseudogene) ML0305c, len: 1445 bp. Possible pseudogene of M. tuberculosis orthologue Rv0537c (1434 bp) (Best blastx scores: 503) Yes cell wall and cell processes Rv0537c Rv0537c AL450380.2 Mycobrowser_v4 tRNA 2769260 2769345 . + 0 MLP000046 serV tRNA-Ser anticodon GGA tRNA Ser anticodon GGA, Cove scores: 57.12 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2949306 2949396 . + 0 MLP000047 serX tRNA-Ser anticodon CGA tRNA Ser anticodon CGA, Cove scores: 64.30 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 477372 477956 . + 0 ML0384 sigD Probable alternative RNA polymerase sigma-D factor SigD (pseudogene) ML0384, len: 585 bp. Possible pseudogene of M. tuberculosis orthologue sigD|Rv3414c (639 bp) (Best blastx scores: 312) Yes information pathways Rv3414c Rv3414c AL450380.2 Mycobrowser_v4 tRNA 2989364 2989437 . + 0 MLP000048 glyU tRNA-Gly anticodon CCC tRNA Gly anticodon CCC, Cove scores: 81.00 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 123370 124380 . + 0 ML0099 ML0099 Probable conserved membrane protein ML0099, len: 336 aa. Probable conserved membrane protein, highly similar to Rv3802c|O53581|AL123456 hypothetical protein from M. tuberculosis (336 aa), Fasta scores: E(): 0, (75.5% identity in 335 aa overlap). Contains hydrophobic, possible membrane-spanning region near the N-terminus Q9CDB3 No cell wall and cell processes PF01083 Q9CDB3 GO:0008152,GO:0016787 Rv3802c Rv3802c AL450380.2 Mycobrowser_v4 CDS 152204 152371 . - 0 ML0111c ML0111c Hypothetical protein (pseudogene) ML0111c, len: 168 bp. Possible pseudogene of M. tuberculosis orthologue Rv3788 (486 bp) (Best blastx scores: 157) Yes conserved hypotheticals Rv3788 Rv3788 AL450380.2 Mycobrowser_v4 CDS 310900 311580 . + 0 ML0237 ML0237 Hypothetical protein (pseudogene) ML0237, len: 681 bp. Possible pseudogene of M. tuberculosis orthologue Rv1006 (1704 bp) (Best blastx scores: 389) Yes conserved hypotheticals Rv1006 Rv1006 AL450380.2 Mycobrowser_v4 CDS 164082 164876 . - 0 ML0122c hisC2 Probable histidinol-phosphate aminotransferase HisC2 (pseudogene) ML0122c, len: 795 bp. Possible pseudogene of M. tuberculosis orthologue Rv3772|hisC2 (1062 bp) (Best blastx scores: 574). Also similar to ML1830c a possible pseudogene similar to M. tuberculosis hisC2. Yes intermediary metabolism and respiration Rv3772 Rv3772 AL450380.2 Mycobrowser_v4 CDS 166460 166833 . + 0 ML0123 ML0123 Conserved hypothetical protein (pseudogene) ML0123, len: 376 bp. Possible pseudogene of M. tuberculosis orthologue Rv3767c (945 bp) (Best blastx scores: 169) Yes lipid metabolism Rv3767c Rv3767c AL450380.2 Mycobrowser_v4 CDS 360751 361125 . + 0 ML0278 ML0278 Conserved hypothetical protein (pseudogene) ML0278, len: 375 bp. Possible pseudogene similar to M. tuberculosis ortholog Rv0387c (735 bp) (Best blastx scores: 97). Yes conserved hypotheticals Rv0387c Rv0387c AL450380.2 Mycobrowser_v4 CDS 1117523 1117780 . - 0 ML0947c ML0947c hypothetical protein ML0947c, len: 85 aa. Hypothetical unknown protein. Q9CCD2 No unknown Q9CCD2 AL450380.2 Mycobrowser_v4 CDS 220591 221452 . - 0 ML0157c ML0157c Possible oxidoreductase (pseudogene) ML0157c, len: 862 bp. Possible pseudogene of M. tuberculosis orthologue Rv0953c (849 bp) (Best blastx scores: 518) Yes intermediary metabolism and respiration Rv0953c Rv0953c AL450380.2 Mycobrowser_v4 tRNA 1535955 1536040 . - 0 MLP000022 leuU tRNA-Leu anticodon GAG tRNA Leu anticodon GAG, Cove scores: 59.66 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 1602380 1602454 . - 0 MLP000023 valU tRNA-Val anticodon GAC tRNA Val anticodon GAC, Cove scores: 88.42 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 228347 229628 . + 0 ML0163 ML0163 Conserved hypothetical protein (pseudogene) ML0163, len: 1282 bp. Possible pseudogene of M. tuberculosis orthologue Rv0959 (2019 bp) (Best blastx scores: 266) Yes conserved hypotheticals Rv0959 Rv0959 AL450380.2 Mycobrowser_v4 CDS 229629 230493 . + 0 ML0164 fadE13 Probable acyl-CoA dehydrogenase FadE13 (pseudogene) ML0164, len: 865 bp. Possible pseudogene of M. tuberculosis orthologue fadE13|Rv0975c (1149 bp) (Best blastx scores: 280) Yes lipid metabolism Rv0975c Rv0975c AL450380.2 Mycobrowser_v4 CDS 230546 231663 . + 0 ML0165 accD2 Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 (pseudogene) ML0165, len: 1118 bp. Possible pseudogene of M. tuberculosis orthologue accD2|Rv0974c (1590 bp) (Best blastx scores: 451). Yes lipid metabolism Rv0974c Rv0974c AL450380.2 Mycobrowser_v4 CDS 497358 498002 . + 0 ML0399 ML0399 Conserved hypothetical protein (pseudogene) ML0399, len: 645 bp. Possible pseudogene of M. tuberculosis orthologue Rv3395c (615 bp) (Best blastx scores: 208) Yes conserved hypotheticals Rv3395c Rv3395c AL450380.2 Mycobrowser_v4 CDS 231672 233398 . + 0 ML0166 accA2 Probable acetyl-/propionyl-CoA carboxylase (alpha subunit) AccA2 (pseudogene) ML0166, len: 1727 bp. Possible pseudogene of M. tuberculosis orthologue accA2|Rv0973c (2004 bp) (Best blastx scores: 317) Yes lipid metabolism Rv0973c Rv0973c AL450380.2 Mycobrowser_v4 CDS 233449 234077 . + 0 ML0167 fadE12 Probable acyl-CoA dehydrogenase FadE12 (pseudogene) ML0167, len: 629 bp. Possible pseudogene of M. tuberculosis orthologue fadE12|Rv0972c (1167 bp) (Best blastx scores: 396) Yes lipid metabolism Rv0972c Rv0972c AL450380.2 Mycobrowser_v4 CDS 234124 234820 . + 0 ML0168 echA7 Probable enoyl-CoA hydratase EchA7 (pseudogene) ML0168, len: 697 bp. Possible pseudogene of M. tuberculosis orthologue echA7|Rv0971c (810 bp) (Best blastx scores: 174) Yes lipid metabolism Rv0971c Rv0971c AL450380.2 Mycobrowser_v4 CDS 767601 767933 . + 0 ML0635 ML0635 Hypothetical protein (pseudogene) ML0635, len: 333 bp. Possible pseudogene of M. tuberculosis orthologue Rv2360c (429 bp) (Best blastx scores: 192). Yes conserved hypotheticals Rv2360c Rv2360c AL450380.2 Mycobrowser_v4 CDS 305368 305706 . + 0 ML0234 lsr2 Lsr2 protein precursor (15 kDa antigen)(A15) ML0234, len: 112 aa. lsr2, highly similar to Rv3597c|LSR2_MYCTU|O06285 lsr2, probable lsr protein from M. tuberculosis (112 aa), Fasta scores: E(): 0, (92.9% identity in 112 aa overlap). Homologues also occur in Streptomyces coelicolor e.g. Q9X8N1|AL049628 putative lsr2-like protein SCE94.26C (111 aa), Fasta scores: E(): 7.3e-18, (56.3% identity in 112 aa overlap). P24094 No cell wall and cell processes, information pathways P24094 GO:0006955 Rv3597c Rv3597c AL450380.2 Mycobrowser_v4 CDS 335129 335812 . + 0 ML0256 ML0256 Possible conserved membrane protein ML0256, len: 227 aa. Possible conserved membrane protein, highly similar to Rv1024|P96376|AL123456 hypothetical protein from M. tuberculosis (228 aa), Fasta scores: E(): 0, (70.5% identity in 220 aa overlap). Also similar to putative membrane protein from Streptomyces coelicolor A3(2) (174 aa). Contains a hydrophobic, possible membrane-spanning region. Q9CD41 No cell wall and cell processes PF04977 Q9CD41 GO:0007049 Rv1024 Rv1024 AL450380.2 Mycobrowser_v4 CDS 614637 615000 . - 0 ML0506c ML0506c Conserved hypothetical protein (pseudogene) ML0506c, len: 364 bp. Possible pseudogene similar to M. tuberculosis orthologue Rv2570 (390 bp) (Best blastx scores: 169). Yes conserved hypotheticals Rv2570 Rv2570 AL450380.2 Mycobrowser_v4 CDS 364131 364909 . + 0 ML0282 ML0282 Probable conserved integral membrane protein (pseudogene) ML0282, len: 779 bp. Possible pseudogene of M. tuberculosis orthologue Rv0359 (780 bp) (Best blastx scores: 161). Yes cell wall and cell processes Rv0359 Rv0359 AL450380.2 Mycobrowser_v4 CDS 661596 662510 . - 0 ML0545c lipH Probable lipase LipH (pseudogene) ML0545c, len: 915 bp. Possible pseudogene of M. tuberculosis orthologue lipH|Rv1399c (960 bp) (Best blastx scores: 213). Yes intermediary metabolism and respiration Rv1399c Rv1399c AL450380.2 Mycobrowser_v4 CDS 505778 506545 . + 0 ML0408 ML0408 Possible IS1081 transposase (pseudogene) ML0408, len: 768 bp. Possible pseudogene similar to M. tuberculosis IS1081 transposase (Best blastx scores: 140) Yes unknown AL450380.2 Mycobrowser_v4 CDS 537010 538545 . + 0 ML0437 accA1 Probable acetyl/propionyl-CoA carboxylase [alpha subunit] AccA1 (pseudogene) ML0437, len: 1536 bp. Possible pseudogene of M. tuberculosis orthologue accA1|Rv2501c (1965 bp) (Best blastx scores: 865) Yes lipid metabolism Rv2501c Rv2501c AL450380.2 Mycobrowser_v4 CDS 579204 579571 . - 0 ML0477c ML0477c Probable conserved integral membrane protein (pseudogene) ML0477c, len: 368 bp. Possible pseudogene of M. tuberculosis orthologue Rv2600 (402 bp) (Best blastx scores: 202) Yes cell wall and cell processes Rv2600 Rv2600 AL450380.2 Mycobrowser_v4 CDS 611088 612391 . - 0 ML0504c ML0504c Transposase (pseudogene) ML0504c, len: 1304 bp. Possible pseudogene similar to transposase Q9K502 from Mycobacterium avium istA (Best blastx scores: 250). Yes unknown AL450380.2 Mycobrowser_v4 CDS 612561 613459 . - 0 ML0505c ML0505c Probable transposase (pseudogene) ML0505c, len: 899 bp. Possible pseudogene similar to M. tuberculosis transposase Rv2424c (1002 bp) (Best blastx scores: 206) Yes unknown AL450380.2 Mycobrowser_v4 CDS 33100 33705 . + 0 ML0028 ML0028 Conserved hypothetical protein ML0028, len: 201 aa. Conserved hypothetical protein, highly similar to Rv0038|P71608|AL123456 hypothetical protein from M. tuberculosis (202 aa), Fasta scores: E(): 0, (88.1% identity in 202 aa overlap). Similar to CAB72194|AL138851 hypothetical protein SCE59.07C from Streptomyces coelicolor (193 aa), Fasta scores: E(): 3.5e-28, (45.6% identity in 182 aa overlap) and shows weak similarity to many other bacterial hypothetical proteins. Previously sequenced as Q50191|Z70722 (202 aa), Fasta scores: E(): 0, (100.0% identity in 201 aa overlap). Q50191 No conserved hypotheticals PF02622 Q50191 Rv0038 Rv0038 AL450380.2 Mycobrowser_v4 tRNA 165035 165127 . + 0 MLP000005 serT tRNA-Ser anticodon GCT tRNA Ser anticodon GCT, Cove scores: 56.23 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 165147 165219 . + 0 MLP000006 argU tRNA-Arg anticodon ACG tRNA Arg anticodon ACG, Cove scores: 76.52 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 73832 74366 . - 0 ML0059c ML0059c Hypothetical alanine rich protein (pseudogene) ML0059c, len: 535 bp. Possible pseudogene of M. tuberculosis orthologue Rv3863 (1176 bp) (Best blastx scores: 119) Yes conserved hypotheticals Rv3863 Rv3863 AL450380.2 Mycobrowser_v4 CDS 76494 76713 . - 0 ML0060c ML0060c Conserved hypothetical protein (pseudogene) ML0060c, len: 220 bp. Possible pseudogene of M. tuberculosis orthologue Rv3860 (1170 bp) (Best blastx scores: 354) Yes conserved hypotheticals Rv3860 Rv3860 AL450380.2 Mycobrowser_v4 CDS 84980 85727 . + 0 ML0063 ML0063 Conserved hypothetical protein (pseudogene) ML0063, len: 748 bp. Possible pseudogene of M. tuberculosis orthologue Rv3856c (1005 bp) (Best blastx scores: 211) Yes conserved hypotheticals Rv3856c Rv3856c AL450380.2 Mycobrowser_v4 tRNA 271901 271976 . + 0 MLP000008 thrU tRNA-Thr anticodon CGT tRNA Thr anticodon CGT, Cove scores: 85.20 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 236614 237352 . + 0 ML0171 ML0171 Conserved hypothetical protein (pseudogene) ML0171, len: 739 bp. Possible pseudogene of M. tuberculosis orthologue Rv0963c (801 bp) (Best blastx scores: 311) Yes conserved hypotheticals Rv0963c Rv0963c AL450380.2 Mycobrowser_v4 CDS 237609 238202 . + 0 ML0172 lprP Possible lipoprotein LprP (pseudogene) ML0172, len: 594 bp. Possible pseudogene of M. tuberculosis orthologue lprP|Rv0962c (675 bp) (Best blastx scores: 310) Yes cell wall and cell processes Rv0962c Rv0962c AL450380.2 Mycobrowser_v4 CDS 89620 90336 . - 0 ML0068c ML0068c Conserved hypothetical protein ML0068c, len: 238 aa. Conserved hypothetical protein, highly similar to Rv3850|P96227|AL123456 hypothetical protein from M. tuberculosis (218 aa), Fasta scores: E(): 0, (78.3% identity in 217 aa overlap). Q9CDD0 No conserved hypotheticals Q9CDD0 Rv3850 Rv3850 AL450380.2 Mycobrowser_v4 CDS 662675 663498 . - 0 ML0546c lipI Probable lipase LipI (pseudogene) ML0546c, len: 824 bp. Possible pseudogene of M. tuberculosis orthologue lipI|Rv1400c (963 bp) (Best blastx scores: 262). Yes intermediary metabolism and respiration Rv1400c Rv1400c AL450380.2 Mycobrowser_v4 CDS 2036005 2037307 . + 0 ML1690 ML1690 Probable conserved integral membrane protein (pseudogene) ML1690, len: 1303 bp. Possible pseudogene of M. tuberculosis orthologue Rv2994 (1338 bp) (Best blastx scores: 382). Yes cell wall and cell processes Rv2994 Rv2994 AL450380.2 Mycobrowser_v4 CDS 90521 90919 . - 0 ML0069c ML0069c Conserved hypothetical protein ML0069c, len: 132 aa. Conserved hypothetical protein, highly similar to Rv3849|P96228|AL123456) hypothetical protein from M. tuberculosis (132 aa), Fasta scores: E(): 0, (84.0% identity in 131 aa overlap). Q9CDC9 No conserved hypotheticals, regulatory proteins Q9CDC9 Rv3849 Rv3849 AL450380.2 Mycobrowser_v4 CDS 91296 91559 . - 0 ML0070c ML0070c Hypothetical protein ML0070c, len: 87 aa. Hypothetical unknown protein. Q9CDC8 No unknown Q9CDC8 AL450380.2 Mycobrowser_v4 CDS 62201 63109 . - 0 ML0051c PPE68 PPE family protein ML0051c, len: 302 aa. Member of the Mycobacteria PPE family. Similar to Rv3873|O69738|AL123456 PPE-family protein from M. tuberculosis (368 aa), Fasta scores: E(): 6.1e-32, (46.2% identity in 288 aa overlap). Lacks the PPE motif at the N-terminus. N-terminus is similar to the N-termini of ML0539, ML1828 and ML1991. Previously sequenced as O33085|Y14967 (302 aa), Fasta scores: E(): 0, (100.0% identity in 302 aa overlap). Contains Pfam match to entry PF00823 PPE, PPE family. Q7AQP1 No PE/PPE PF00823 Q7AQP1 Rv3873 Rv3873 AL450380.2 Mycobrowser_v4 CDS 95965 96439 . - 0 ML0075c bfrB Possible bacterioferritin BfrB (pseudogene) ML0075c, len: 475 bp. Possible pseudogene of M. tuberculosis orthologue bfrB|Rv3841 (546 bp) (Best blastx scores: 190) Yes intermediary metabolism and respiration Rv3841 Rv3841 AL450380.2 Mycobrowser_v4 CDS 97037 97282 . - 0 ML0076c ML0076c Possible transcriptional regulator protein (pseudogene) ML0076c, len: 246 bp. Possible pseudogene of M. tuberculosis orthologue Rv3840 (414 bp) (Best blastx scores: 196) Yes regulatory proteins Rv3840 Rv3840 AL450380.2 Mycobrowser_v4 CDS 97832 98119 . - 0 ML0077c ML0077c Conserved hypothetical protein (pseudogene) ML0077c, len: 288 bp. Possible pseudogene of M. tuberculosis orthologue Rv3839 (777 bp) (Best blastx scores: 251) Yes conserved hypotheticals Rv3839 Rv3839 AL450380.2 Mycobrowser_v4 CDS 100374 100651 . - 0 ML0080c ML0080c Conserved hypothetical protein (pseudogene) ML0080c, len: 278 bp. Possible pseudogene of M. tuberculosis orthologue Rv3836 (414 bp) (Best blastx scores: 137) Yes conserved hypotheticals Rv3836 Rv3836 AL450380.2 Mycobrowser_v4 CDS 105732 106191 . - 0 ML0083c ML0083c Hypothetical protein (pseudogene) ML0083c, len: 460 bp. Possible pseudogene of M. tuberculosis orthologue Rv3831 (483 bp) (Best blastx scores: 151) Yes conserved hypotheticals Rv3831 Rv3831 AL450380.2 Mycobrowser_v4 CDS 106286 106599 . - 0 ML0084c ML0084c Hypothetical protein (pseudogene) ML0084c, len: 314 bp. Possible pseudogene of M. tuberculosis orthologue Rv3819 (336 bp) (Best blastx scores: 138) Yes conserved hypotheticals Rv3819 Rv3819 AL450380.2 Mycobrowser_v4 CDS 106635 108159 . - 0 ML0085c ML0085c hypothetical protein (pseudogene) ML0085c, len: 1525 bp. Possible pseudogene of M. tuberculosis orthologue Rv3818 (1551 bp) (Best blastx scores: 275). Yes conserved hypotheticals Rv3818 Rv3818 AL450380.2 Mycobrowser_v4 CDS 108258 108991 . - 0 ML0086c ML0086c Possible phosphotransferase (pseudogene) ML0086c, len: 734 bp. Possible pseudogene of M. tuberculosis orthologue Rv3817 (756 bp) (Best blastx scores: 203) Yes intermediary metabolism and respiration Rv3817 Rv3817 AL450380.2 Mycobrowser_v4 CDS 109842 110234 . + 0 ML0088 ML0088 Possible acyltransferase (pseudogene) ML0088, len: 393 bp. Possible pseudogene of M. tuberculosis orthologue Rv3815c (756 bp) (Best blastx scores: 228) Yes intermediary metabolism and respiration Rv3815c Rv3815c AL450380.2 Mycobrowser_v4 CDS 111660 112884 . - 0 ML0090c ML0090c Conserved hypothetical protein (pseudogene) ML0090c, len: 1225 bp. Possible pseudogene of M. tuberculosis orthologue Rv3811 (1620 bp) (Best blastx scores: 228) Yes conserved hypotheticals Rv3811 Rv3811 AL450380.2 Mycobrowser_v4 CDS 227008 227286 . - 0 ML0162c ML0162c Hypothetical protein ML0162c, len: 92 aa. Hypothetical unknown protein. Improbable CDS suggested by GC frameplot. Possibly the remains of a disrupted gene. Previously sequenced as Q9Z5H3|AL035500 (92 aa), Fasta scores: E(): 0, (98.9% identity in 92 aa overlap). Q7AQN3 No unknown Q7AQN3 AL450380.2 Mycobrowser_v4 CDS 205253 206396 . - 0 ML0144c ML0144c Putative group II intron maturase-related protein (pseudogene) ML0144c, len: 1144 bp. Possible pseudogene, similar to several maturases e.g. Q9MD87|AF218567 putative maturase from Cryphonectria parasitica (Cheshnut blight fungus) (2334 bp), (blastx scores: 143); and Rv0071|O53616 Putative maturase from M. tuberculosis (705 bp), (blastx scores: 153). Belongs to the LEPREP family of dispersed repeats (see citation below) Yes unknown AL450380.2 Mycobrowser_v4 tRNA 524676 524751 . - 0 MLP000011 lysU tRNA-Lys anticodon CTT tRNA Lys anticodon CTT, Cove scores: 84.12 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 526169 526244 . - 0 MLP000012 hisT tRNA-His anticodon GTG tRNA His anticodon GTG, Cove scores: 82.48 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 340549 341173 . - 0 ML0261c trcR Two-component transcriptional regulator TrcR (pseudogene) ML0261c, len: 625 bp. Possible pseudogene of M. tuberculosis orthologue Rv1033c|trcR (774 bp) (Best blastx scores: 192). Yes regulatory proteins Rv1033c Rv1033c AL450380.2 Mycobrowser_v4 CDS 480094 480507 . - 0 ML0386c ML0386c Conserved hypothetical protein ML0386c, len: 137 aa. Conserved hypothetical protein, equivalent to Rv3412|YY12_MYCTU|Q50714 conserved hypothetical protein from M. tuberculosis (136 aa), Fasta scores: E(): 0, (93.4% identity in 136 aa overlap). Also similar to Q8NSR6 Hypothetical protein Cgl0602 from Corynebacterium glutamicum (126 aa), Fasta scores: E(): 0, (42.2% identity in 116 aa overlap). Previously sequenced as YY12_MYCLE|Q49742 (137 aa), Fasta scores: E(): 0, (99.3% identity in 137 aa overlap). Q49742 No conserved hypotheticals Q49742 Rv3412 Rv3412 AL450380.2 Mycobrowser_v4 CDS 879313 879459 . - 0 ML0738c pstA2 Phosphate-transport integral membrane ABC transporter PstA2 (pseudogene) ML0738c, len: 147 bp. Possible pseudogene of M. tuberculosis orthologue pstA2|Rv0936 (906 bp) (Best blastx scores: 95). Yes cell wall and cell processes Rv0936 Rv0936 AL450380.2 Mycobrowser_v4 CDS 882888 883983 . + 0 ML0742 pstS2 Periplasmic phosphate-binding lipoprotein PstS2 (pseudogene) ML0742, len: 1096 bp. Possible pseudogene of M. tuberculosis orthologue pstS2|Rv0932c (1113 bp) (Best blastx scores: 440). Yes cell wall and cell processes Rv0932c Rv0932c AL450380.2 Mycobrowser_v4 CDS 908397 909754 . - 0 ML0766c ML0766c Conserved hypothetical protein (pseudogene) ML0766c, len: 1358 bp. Possible pseudogene of M. tuberculosis orthologue Rv3254 (1389 bp) (Best blastx scores: 402). Yes conserved hypotheticals Rv3254 Rv3254 AL450380.2 Mycobrowser_v4 CDS 909847 911323 . + 0 ML0767 ML0767 Possible cationic amino acid transport integral membrane protein (pseudogene) ML0767, len: 1477 bp. Possible pseudogene of M. tuberculosis orthologue Rv3253c (1488 bp) (Best blastx scores: 1109). Yes cell wall and cell processes Rv3253c Rv3253c AL450380.2 Mycobrowser_v4 tRNA 160312 160401 . + 0 MLP000004 serU tRNA-Ser anticodon TGA tRNA Ser anticodon TGA, Cove scores: 59.58 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 251305 251377 . + 0 MLP000007 alaV tRNA-Ala anticodon CGC tRNA Ala anticodon CGC, Cove scores: 82.84 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 326132 326203 . - 0 MLP000009 glnT tRNA-Gln anticodon TTG tRNA Gln anticodon TTG, Cove scores: 52.56 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 344340 344413 . + 0 MLP000010 leuX tRNA-Leu anticodon TAA tRNA Leu anticodon TAA, Cove scores: 63.13 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 1316303 1316378 . - 0 MLP000015 argV tRNA-Arg anticodon CCG tRNA Arg anticodon CCG, Cove scores: 91.71 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 1374079 1374161 . + 0 MLP000019 leuW tRNA-Leu anticodon TAG tRNA Leu anticodon TAG, Cove scores: 55.29 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 393501 393921 . + 0 ML0307 ML0307 Conserved hypothetical protein (pseudogene) ML0307, len: 421 bp. Possible pseudogene of M. tuberculosis orthologue Rv0434 (654 bp) (Best blastx scores: 130) Yes conserved hypotheticals Rv0434 Rv0434 AL450380.2 Mycobrowser_v4 CDS 452940 453842 . + 0 ML0359 ML0359 Probable short-chain dehydrogenase/reductase (pseudogene) ML0359, len: 903 bp. Possible pseudogene of M. tuberculosis orthologue Rv3502c (954 bp) (Best blastx scores: 300) Yes intermediary metabolism and respiration Rv3502c Rv3502c AL450380.2 Mycobrowser_v4 CDS 2098940 2099948 . + 0 ML1739 dinP Probable DNA-damage-inducible protein DinP (pseudogene) ML1739, len: 1009 bp. Possible pseudogene of M. tuberculosis orthologue dinP|Rv3056 (1041 bp) (Best blastx scores: 362). Yes information pathways Rv3056 Rv3056 AL450380.2 Mycobrowser_v4 CDS 420550 420877 . - 0 ML0329c ML0329c Conserved hypothetical protein (pseudogene) ML0329c, len: 328 bp. Possible pseudogene of M. tuberculosis orthologue Rv1942c (330 bp) (Best blastx scores: 168) Yes virulence, detoxification, adaptation Rv1942c Rv1942c AL450380.2 Mycobrowser_v4 CDS 420877 420990 . - 0 ML0330c ML0330c Conserved hypothetical protein (pseudogene) ML0330c, len: 114 bp. Possible pseudogene of M. tuberculosis orthologue Rv1943c (378 bp) (Best blastx scores: 154) Yes virulence, detoxification, adaptation Rv1943c Rv1943c AL450380.2 Mycobrowser_v4 CDS 421106 422311 . - 0 ML0331c arsB2 Possible arsenical pump integral membrane protein ArsB2 (pseudogene) ML0331c, len: 1206 bp. Possible pseudogene of M. tuberculosis orthologue arsB2|Rv3578 (1242 bp) (Best blastx scores: 423) Yes cell wall and cell processes Rv3578 Rv3578 AL450380.2 Mycobrowser_v4 CDS 17483 18283 . + 0 ML0014 ML0014 Probable conserved membrane protein (pseudogene) ML0014, len: 801 bp. Possible pseudogene of M. tuberculosis orthologue Rv0012 (789 bp) (Best blastx scores: 411) Yes cell wall and cell processes Rv0012 Rv0012 AL450380.2 Mycobrowser_v4 tRNA 780285 780361 . + 0 MLP000013 metU tRNA-Met anticodon CAT tRNA Met anticodon CAT, Cove scores: 88.77 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 663497 663988 . + 0 ML0547 ML0547 Possible membrane protein (pseudogene) ML0547, len: 492 bp. Possible pseudogene of M. tuberculosis orthologue Rv1401 (603 bp) (Best blastx scores: 114) Yes cell wall and cell processes Rv1401 Rv1401 AL450380.2 Mycobrowser_v4 CDS 12856 13230 . - 0 ML0008c ML0008c Hypothetical protein ML0008c, len: 124 aa. Hypothetical unknown protein. Q9CDF1 No unknown Q9CDF1 AL450380.2 Mycobrowser_v4 CDS 13775 13966 . + 0 ML0009 ML0009 Hypothetical protein ML0009, len: 63 aa. Hypothetical unknown protein. Q9CDF0 No unknown Q9CDF0 AL450380.2 Mycobrowser_v4 CDS 422318 423056 . - 0 ML0332c ML0332c Conserved hypothetical protein (pseudogene) ML0332c, len: 739 bp. Possible pseudogene of M. tuberculosis orthologue Rv3577 (867 bp) (Best blastx scores: 257). Yes conserved hypotheticals Rv3577 Rv3577 AL450380.2 Mycobrowser_v4 CDS 424107 424679 . - 0 ML0334c lppH Possible conserved lipoprotein LppH (pseudogene) ML0334c, len: 573 bp. Possible pseudogene of M. tuberculosis orthologue lppH|Rv3576 (714 bp) (Best blastx scores: 216). Note that previously known as pknM. Yes cell wall and cell processes Rv3576 Rv3576 AL450380.2 Mycobrowser_v4 CDS 2100936 2101545 . - 0 ML1741c ML1741c Possible transcriptional regulatory protein (pseudogene) ML1741c, len: 610 bp. Possible pseudogene of M. tuberculosis orthologue Rv3058c (651 bp) (Best blastx scores: 207). Yes regulatory proteins Rv3058c Rv3058c AL450380.2 Mycobrowser_v4 CDS 4435 5004 . + 0 ML0004 ML0004 Conserved hypothetical protein ML0004, len: 189 aa. Conserved hypothetical protein (see citation below), similar to hypothetical proteins from mycobacteria e.g. Rv0004|P71573|AL123456 from M. tuberculosis (187 aa), Fasta scores: E(): 0, (77.2% identity in 167 aa overlap). Previously sequenced as Q50181|Z70722 (199 aa), Fasta scores: E(): 0, (99.5% identity in 187 aa overlap). Q9CDF4 No conserved hypotheticals PF05258 Q9CDF4 Rv0004 Rv0004 AL450380.2 Mycobrowser_v4 CDS 11195 12106 . + 0 ML0007 ML0007 Possible conserved membrane protein ML0007, len: 303 aa. Possible conserved membrane protein, similar to Rv0007|P71575|AL123456 possible conserved membrane protein from M. tuberculosis (304 aa), Fasta scores: E(): 0, (54.2% identity in 319 aa overlap). Previously sequenced as O32870|Z70722 (303 aa), Fasta scores: E(): 0, (99.7% identity in 303 aa overlap). Contains hydrophobic, possible membrane-spanning regions near the C-terminus. Contains a region identical to ML2630. O32870 No cell wall and cell processes O32870 GO:0005886,GO:0016021 Rv0007 Rv0007 AL450380.2 Mycobrowser_v4 CDS 2101770 2103145 . + 0 ML1742 cyp136 Probable cytochrome P450 136 Cyp136 (pseudogene) ML1742, len: 1376 bp. Possible pseudogene of M. tuberculosis orthologue Rv3059|cyp136 (1479 bp) (Best blastx scores: 393). Yes intermediary metabolism and respiration Rv3059 Rv3059 AL450380.2 Mycobrowser_v4 CDS 31015 31651 . - 0 ML0026 PPE PPE-family protein (pseudogene) ML0026, len: 637 bp. Possible pseudogene similar to M. tuberculosis PPE protein, most similar to PPE26|Rv1789 (Best blastx scores: 99), but similar to several others e.g. PPE31, PPE22, PPE14 etc. Yes unknown AL450380.2 Mycobrowser_v4 CDS 32113 32920 . - 0 ML0027c ML0027c Probable conserved integral membrane protein (pseudogene) ML0027c, len: 808 bp. Possible pseudogene of M. tuberculosis orthologue Rv0037c (1326 bp) (Best blastx scores: 178) Yes cell wall and cell processes Rv0037c Rv0037c AL450380.2 Mycobrowser_v4 tRNA 12404 12479 . + 0 MLP000002 alaT tRNA-Ala anticodon TGC tRNA Ala anticodon TGC, Cove scores: 86.68 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 15426 15767 . - 0 ML0010c ML0010c Possible membrane protein (pseudogene) ML0010c, len: 342 bp. Possible pseudogene of M. tuberculosis orthologue Rv0008c (438 bp) (Best blastx scores: 124) Yes cell wall and cell processes Rv0008c Rv0008c AL450380.2 Mycobrowser_v4 tRNA 28890 28972 . + 0 MLP000003 leuT tRNA-Leu anticodon CAG tRNA Leu anticodon CAG, Cove scores: 63.58 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 150128 151510 . - 0 ML0109c ML0109c Probable oxidoreductase ML0109c, len: 460 aa. Probable oxidoreductase (EC 1.-.-.-), highly similar to Rv3790|P72056|AL123456) probable oxidoreductase from M. tuberculosis (461 aa), Fasta scores: E(): 0, (86.6% identity in 461 aa overlap). Also similar to many bacterial putative oxidoreductases. Contains Pfam match to entry PF01565 FAD_binding_4, FAD binding domain. Q9CDA4 No intermediary metabolism and respiration, lipid metabolism PF01565,PF04030 Q9CDA4 GO:0050660,GO:0016020,GO:0003885 Rv3790 Rv3790 AL450380.2 Mycobrowser_v4 CDS 751048 751489 . + 0 ML0618 cysA1 Probable sulphate transport ATP-binding protein ABC transporter CysA1 (pseudogene) ML0618, len: 442 bp. Possible pseudogene of M. tuberculosis orthologue cysA1|Rv2397c (1056 bp) (Best blastx scores: 153). Yes cell wall and cell processes Rv2397c Rv2397c AL450380.2 Mycobrowser_v4 CDS 171616 172923 . + 0 ML0128 ML0128 Possible glycosyl transferase ML0128, len: 435 aa. Possible glycosyl transferase (EC 2.4.1.-) (see citation below), highly similar to the possible glycosyl transferase from M. tuberculosis e.g. Rv2958c|P95134|AL123456 (428 aa), Fasta scores: E(): 0, (75.1% identity in 417 aa overlap) and Rv2962c|P95130|AL123456 (449 aa), Fasta scores: E(): 0, (74.4% identity in 425 aa overlap). Similar to Q9ZGH7|AF079762 desVII, glycosyl transferase from a macrolide antibiotic biosynthesis gene cluster in Streptomyces venezuelae (426 aa), Fasta scores: E(): 1.1e-09, (30.9% identity in 223 aa overlap). Shows similarity to bacterial and eukaryotic glycosyl transferases. Also similar to ML0125 and shows weaker similarity to ML0985 from M. leprae. Q9CD88 No intermediary metabolism and respiration PF00201 Q9CD88 GO:0016758,GO:0008152 Rv2958c Rv2958c AL450380.2 Mycobrowser_v4 CDS 200930 201848 . + 0 ML0140 ML0140 Conserved hypothetical protein (pseudogene) ML0140, len: 919 bp. Possible pseudogene similar to M. tuberculosis Rv0221 (1410 bp) (Best blastx scores: 157) Yes unknown AL450380.2 Mycobrowser_v4 CDS 204890 204988 . - 0 ML0143c ML0143c Possible transposase remnant (pseudogene) ML0143c, len: 99 bp. Possible transposase remnant, similar to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 93); and to Q9R9U9|AJ245436 transposase tnpa1 from Pseudomonas putida (1065 bp), (blastx scores: 89). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 188551 189252 . + 0 ML0136 lppX Probable conserved lipoprotein LppX ML0136, len: 233 aa. Probable lppX, conserved lipoprotein, highly similar to Rv2945c|LPPX_MYCTU|Z83858 lppX, conserved lipoprotein from M. tuberculosis (233 aa), Fasta scores: E(): 0, (76.4% identity in 233 aa overlap); and similar to other probable mycobacterial lipoproteins e.g. LPRG_MYCTU|AJ000500 lprG, 27 kDa lipoprotein antigen from Mycobacterium bovis (236 aa), Fasta scores: E(): 2.5e-13, (31.2% identity in 202 aa overlap). And is similar to ML0557 from M. leprae. Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CD80 No cell wall and cell processes PF07161 Q9CD80 GO:0005886 Rv2945c Rv2945c AL450380.2 Mycobrowser_v4 tRNA 1531701 1531777 . - 0 MLP000021 leuV tRNA-Leu anticodon CAA tRNA Leu anticodon CAA, Cove scores: 48.78 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 209823 210314 . + 0 ML0148 ML0148 Possible formamidopyrimidine-DNA glycosylase (pseudogene) ML0148, len: 492 bp. Possible pseudogene of M. tuberculosis orthologue Rv0944 (477 bp) (Best blastx scores: 261) Yes information pathways Rv0944 Rv0944 AL450380.2 Mycobrowser_v4 CDS 210338 211058 . + 0 ML0149 ML0149 Probable short-chain dehydrogenase/reductase (pseudogene) ML0149, len: 721 bp. Possible pseudogene of M. tuberculosis orthologue Rv0945 (762 bp) (Best blastx scores: 196) Yes intermediary metabolism and respiration Rv0945 Rv0945 AL450380.2 Mycobrowser_v4 CDS 764434 765813 . - 0 ML0632c amiA2 Probable amidase AmiA2 (pseudogene) ML0632c, len: 1380 bp. Possible pseudogene of M. tuberculosis orthologue amiA2|Rv2363 (Best blastx scores: 975) Yes intermediary metabolism and respiration Rv2363 Rv2363 AL450380.2 Mycobrowser_v4 CDS 204363 204611 . + 0 ML0142 ML0142 Probable membrane protein ML0142, len: 82 aa. Probable membrane protein. Contains hydrophobic, possible membrane-spanning region. Q9CD76 No cell wall and cell processes Q9CD76 AL450380.2 Mycobrowser_v4 CDS 214001 214189 . + 0 ML0152 ML0152 Hypothetical protein ML0152, len: 62 aa. Improbable CDS suggested by GC frameplot. Possibly the remains of a disrupted gene. Q9CD73 No unknown Q9CD73 AL450380.2 Mycobrowser_v4 CDS 208911 209279 . + 0 ML0147 ML0147 conserved hypothetical protein (pseudogene) ML0147, len: 369 bp. Possible pseudogene similar to the N-terminal region (non-repetitive domains) of several M. tuberculosis PE-family proteins e.g. Rv1803c|O53952|AL123456 PE_family, PGRS-subfamily protein (1917 bp). The start codon appears to have been mutated (ATG to ATA). Yes unknown AL450380.2 Mycobrowser_v4 CDS 213175 213492 . - 0 ML0151c ML0151c Conserved hypothetical protein ML0151c, len: 105 aa. Conserved hypothetical protein, highly similar to Rv0948c|Y948_MYCTU|P71562 hypothetical protein from M. tuberculosis (105 aa), Fasta scores: E(): 1.9e-32, (83.8% identity in 105 aa overlap). Also similar to CAB82023|AL161755 hypothetical protein SCD63.16C from Streptomyces coelicolor (110 aa), Fasta scores: E(): 3.9e-06, (44.4% identity in 72 aa overlap); and to the N-terminus of two chorismate mutase/prephenate dehydratase. Q9CD74 No conserved hypotheticals, intermediary metabolism and respiration PF01817 Q9CD74 GO:0004106,GO:0009073 Rv0948c Rv0948c AL450380.2 Mycobrowser_v4 tRNA 1785229 1785299 . + 0 MLP000029 glyV tRNA-Gly anticodon TCC tRNA Gly anticodon TCC, Cove scores: 63.84 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 221657 222601 . + 0 ML0158 ML0158 Probable conserved transmembrane protein ML0158, len: 314 aa. Probable conserved transmembrane protein, similar to Rv0954|34KD_MYCTU|P71556 conserved transmembrane protein from M. tuberculosis (303 aa), Fasta scores: E(): 0, (55.8% identity in 312 aa overlap) and to 34KD_MYCPA|Q04959 34 kDa antigenic protein from Mycobacterium paratuberculosis (298 aa), Fasta scores: E(): 0, (61.7% identity in 311 aa overlap). Previously sequenced as O87894|U82111 (336 aa), Fasta scores: E(): 0, (99.7% identity in 314 aa overlap). Contains hydrophobic, membrane-spanning regions. Q9CD70 No cell wall and cell processes Q9CD70 Rv0954 Rv0954 AL450380.2 Mycobrowser_v4 tRNA 1602469 1602542 . - 0 MLP000024 cysU tRNA-Cys anticodon GCA tRNA Cys anticodon GCA, Cove scores: 68.63 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 1602568 1602643 . - 0 MLP000025 glyT tRNA-Gly anticodon GCC tRNA Gly anticodon GCC, Cove scores: 89.46 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 245324 245983 . - 0 ML0179c ML0179c Hypothetical protein (pseudogene) ML0179c, len: 660 bp. Probable pseudogene of M. tuberculosis orthologue Rv0990c (657 bp) (Best blastx scores: 338) Yes conserved hypotheticals Rv0990c Rv0990c AL450380.2 Mycobrowser_v4 CDS 339324 340503 . - 0 ML0260c trcS Two component sensor histidine kinase TrcS (pseudogene) ML0260c, len: 1180 bp. Possible pseudogene of M. tuberculosis orthologue Rv1032c (1530 bp) (Best blastx scores: 284) Yes regulatory proteins Rv1032c Rv1032c AL450380.2 Mycobrowser_v4 CDS 240237 240410 . + 0 ML0173 rpmF Probable 50S ribosomal protein L32 RpmF ML0173, len: 57 aa. Probable rpmF, ribosomal protein L32, similar to many e.g. Rv0979A|P58287|RL32_MYCTU 50S ribosomal protein L32 from M. tuberculosis (57 aa), fasta scores: E(): 4.9e-19, (84.2.462% identity in 57 aa overlap); and R322_STRCO|Q9RL50 probable 50S ribosomal protein from Streptomyces coelicolor (56 aa), fasta scores: E(): 1.5e-09, (63.462% identity in 52 aa overlap). Belongs to the L32P family of ribosomal proteins. Q9CD69 No information pathways PF01783 Q9CD69 GO:0003735,GO:0006412,GO:0015934 Rv0979A Rv0979A AL450380.2 Mycobrowser_v4 CDS 251982 252266 . + 0 ML0186 ML0186 Hypothetical protein (pseudogene) ML0186, len: 285 bp. Possible pseudogene of M. tuberculosis orthologue Rv0997 (432 bp) (Best blastx scores: 101) Yes conserved hypotheticals Rv0997 Rv0997 AL450380.2 Mycobrowser_v4 tRNA 1602822 1602896 . + 0 MLP000026 valT tRNA-Val anticodon CAC tRNA Val anticodon CAC, Cove scores: 85.25 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 254397 255092 . + 0 ML0189 ML0189 Hypothetical protein (pseudogene) ML0189, len: 696 bp. Possible pseudogene of M. tuberculosis orthologue Rv0999 (759 bp) (Best blastx scores: 400) Yes conserved hypotheticals Rv0999 Rv0999 AL450380.2 Mycobrowser_v4 CDS 255879 256895 . + 0 ML0191 arcA Probable arginine deiminase ArcA (pseudogene) ML0191, len: 1017 bp. Possible pseudogene of M. tuberculosis orthologue arcA|Rv1001 (1209 bp) (Best blastx scores: 249) Yes intermediary metabolism and respiration Rv1001 Rv1001 AL450380.2 Mycobrowser_v4 tRNA 1987247 1987321 . - 0 MLP000030 valV tRNA-Val anticodon TAC tRNA Val anticodon TAC, Cove scores: 84.14 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 288678 288923 . + 0 ML0217 ML0217 Hypothetical protein ML0217, len: 81 aa. Hypothetical unknown protein. Possibly the remains of a disrupted gene. Q9CD59 No unknown Q9CD59 AL450380.2 Mycobrowser_v4 CDS 289829 290215 . - 0 ML0218c ML0218c Hypothetical protein ML0218c, len: 128 aa. Hypothetical unknown protein. Improbable CDS suggested by GC frameplot. Possibly the remains of a disrupted gene. Previously sequenced as O69534|AL023093 (128 aa), Fasta scores: E(): 0, (99.2% identity in 128 aa overlap). Q7AQL5 No unknown Q7AQL5 AL450380.2 Mycobrowser_v4 CDS 261342 262320 . - 0 ML0195c ML0195c Conserved hypothetical protein (pseudogene) ML0195c, len: 979 bp. Possible pseudogene of M. tuberculosis orthologue Rv3651 (1038 bp) (Best blastx scores: 218) Yes conserved hypotheticals Rv3651 Rv3651 AL450380.2 Mycobrowser_v4 CDS 263238 264560 . - 0 ML0197c ML0197c Probable helicase (pseudogene) ML0197c, len: 1323 bp. Possible pseudogene of M. tuberculosis orthologue Rv3649 (2316 bp) (Best blastx scores: 213) Yes information pathways Rv3649 Rv3649 AL450380.2 Mycobrowser_v4 CDS 783903 785174 . - 0 ML0647c aofH Probable flavin-containing monoamine oxidase AofH (pseudogene) ML0647c, len: 1272 bp. Possible pseudogene of M. tuberculosis orthologue Rv3170|aofH (1347 bp) (Best blastx scores: 441) Yes intermediary metabolism and respiration Rv3170 Rv3170 AL450380.2 Mycobrowser_v4 CDS 254028 254291 . + 0 ML0188 ML0188 Hypothetical protein ML0188, len: 87 aa. Hypothetical unknown protein. Contains PS01047 Heavy-metal-associated domain. Q9CD63 No unknown Q9CD63 AL450380.2 Mycobrowser_v4 CDS 252658 253719 . + 0 ML0187 ML0187 Conserved hypothetical protein ML0187, len: 353 aa. Conserved hypothetical protein, highly similar to Rv0998|O05581|AL123456 conserved hypothetical protein, possibly cyclic nucleotide-dependent protein kinase from M. tuberculosis (333 aa), Fasta scores: E(): 0, (69.7% identity in 330 aa overlap); and similar to many hypothetical proteins. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain. Contains PS00889 Cyclic nucleotide-binding domain signature 2. Q9CD64 No conserved hypotheticals PF00027 Q9CD64 GO:0008152,GO:0008080 Rv0998 Rv0998 AL450380.2 Mycobrowser_v4 CDS 277944 279039 . + 0 ML0206 ML0206 Probable conserved integral membrane (pseudogene) ML0206, len: 1096 bp. Possible pseudogene of M. tuberculosis orthologue Rv3630 (1296 bp) (Best blastx scores: 392) Yes cell wall and cell processes Rv3630 Rv3630 AL450380.2 Mycobrowser_v4 CDS 280783 281282 . - 0 ML0209c ML0209c Hypothetical protein (pseudogene) ML0209c, len: 500 bp. Possible pseudogene similar to M. tuberculosis Rv1748 (732 bp) (Best blastx scores: 146) Yes unknown AL450380.2 Mycobrowser_v4 CDS 273290 274999 . - 0 ML0203c ML0203c Probable conserved transmembrane protein ML0203c, len: 569 aa. Probable conserved transmembrane protein, highly similar to Rv3635|O06372|AL123456 probable transmembrane protein from M. tuberculosis (591 aa), Fasta scores: E(): 0, (77.2% identity in 569 aa overlap). Previously sequenced as O69545|AL023093 (569 aa), Fasta scores: E(): 0, (99.8% identity in 569 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQM1 No cell wall and cell processes Q7AQM1 Rv3635 Rv3635 AL450380.2 Mycobrowser_v4 CDS 279784 280125 . + 0 ML0208 ML0208 Possible conserved membrane protein ML0208, len: 113 aa. Possible conserved membrane protein, highly similar to Rv3632|O06375|AL123456 conserved membrane protein from M. tuberculosis (114 aa), Fasta scores: E(): 0, (82.0% identity in 111 aa overlap). Previously sequenced as O69541|AL023093 (113 aa), Fasta scores: E(): 0, (100.0% identity in 113 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQL7 No cell wall and cell processes Q7AQL7 Rv3632 Rv3632 AL450380.2 Mycobrowser_v4 CDS 283539 284579 . + 0 ML0212 ML0212 Conserved hypothetical protein (pseudogene) ML0212, len: 1041 bp. Probable pseudogene of M. tuberculosis orthologue Rv3626c (1053 bp) (Best blastx scores: 1003) Yes conserved hypotheticals Rv3626c Rv3626c AL450380.2 Mycobrowser_v4 CDS 286276 286674 . - 0 ML0215c lpqG Probable conserved lipoprotein LpqG (pseudogene) ML0215c, len: 399 bp. Possible pseudogene of M. tuberculosis orthologue lpqG|Rv3623 (723 bp) (Best blastx scores: 222). Yes cell wall and cell processes Rv3623 Rv3623 AL450380.2 Mycobrowser_v4 CDS 286829 287302 . - 0 ML0216c ML0216c Conserved 13E12 repeat family protein (pseudogene) ML0216c, len: 474 bp. Possible pseudogene similar to M. tuberculosis Rv0393 (1326 bp) (Best blastx scores: 102) Yes unknown AL450380.2 Mycobrowser_v4 CDS 290378 290991 . - 0 ML0219c ML0219c Possible dehydrogenase (pseudogene) ML0219c, len: 614 bp. Possible pseudogene similar to M. tuberculosis Rv3729 (1191 bp) (Best blastx scores: 114) Yes unknown AL450380.2 Mycobrowser_v4 CDS 291435 292461 . - 0 ML0220c ML0220c Possible monooxygenase (pseudogene) ML0220c, len: 1027 bp. Possible pseudogene of M. tuberculosis orthologue Rv3618 (1188 bp) (Best blastx scores: 208). Also similar to ML1984c a possible pseudogene similar to M. tuberculosis Rv3618. Yes intermediary metabolism and respiration Rv3618 Rv3618 AL450380.2 Mycobrowser_v4 CDS 292471 293353 . - 0 ML0221c ephA Probable epoxide hydrolase EphA (pseudogene) ML0221c, len: 883 bp. Possible pseudogene of M. tuberculosis orthologue ephA|Rv3617 (969 bp) (Best blastx scores: 177). Yes virulence, detoxification, adaptation Rv3617 Rv3617 AL450380.2 Mycobrowser_v4 CDS 793593 793874 . - 0 ML0656c ML0656c Hypothetical protein ML0656c, len: 93 aa. Hypothetical protein. Previously sequenced as O32893|Z98271 (93 aa), Fasta scores: E(): 0, (100.0% identity in 93 aa overlap). Q7AQH1 No unknown Q7AQH1 AL450380.2 Mycobrowser_v4 tRNA 2033113 2033188 . - 0 MLP000031 gluU tRNA-Glu anticodon CTC tRNA Glu anticodon CTC, Cove scores: 62.17 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2033276 2033350 . - 0 MLP000032 glnU tRNA-Gln anticodon CTG tRNA Gln anticodon CTG, Cove scores: 56.59 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 795538 795864 . - 0 ML0659c ML0659c Hypothetical protein ML0659c, len: 108 aa. Hypothetical protein. Previously sequenced as O32892|Z98271 (108 aa), Fasta scores: E(): 0, (100.0% identity in 108 aa overlap). Q7AQH0 No unknown Q7AQH0 AL450380.2 Mycobrowser_v4 CDS 296696 297550 . + 0 ML0224 folP1 Involved in dihydrofolate biosynthesis (at the second step). Catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [Catalytic activity: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = pyrophosphate + dihydropteroate]. Probable dihydropteroate synthase 1 FolP1 (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate dipyrophosphorylase 1) ML0224, len: 284 aa. Probable folP1, dihydropteroate synthase 1 (EC 2.5.1.15), highly similar to Rv3608c|DHP1_MYCTU|O06274 probable folP1, dihydropteroate synthase 1 from M. tuberculosis (280 aa), Fasta scores: E(): 0, (76.8% identity in 284 aa overlap); and similar to many others e.g. P28822|DHPS_BACSU dihydropteroate synthase from Bacillus subtilis (285 aa). Previously sequenced as O69530|AL023093 (284 aa), Fasta scores: E(): 0, (99.6% identity in 284 aa overlap). Also similar to ML1063 from M. leprae. Mutations in this gene result in diaminodiphenylsulfone resistance. Contains Pfam match to entry PF00809 DHPS, Dihydropteroate synthase. Contains PS00793 Dihydropteroate synthase signature 2. P0C0X1 No intermediary metabolism and respiration PF00809 P0C0X1 GO:0046656,GO:0046677,GO:0004156 2.5.1.15 Rv3608c Rv3608c AL450380.2 Mycobrowser_v4 tRNA 2133851 2133926 . - 0 MLP000033 alaU tRNA-Ala anticodon GGC tRNA Ala anticodon GGC, Cove scores: 82.89 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2135501 2135574 . - 0 MLP000034 metV tRNA-Met anticodon CAT tRNA Met anticodon CAT, Cove scores: 90.06 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 814146 814373 . + 0 ML0679 ML0679 Hypothetical protein ML0679, len: 75 aa. Hypothetical protein. Q9CCM3 No unknown Q9CCM3 AL450380.2 Mycobrowser_v4 CDS 427652 428676 . + 0 ML0338 ML0338 Transcriptional regulatory protein (probably LacI family) (pseudogene) ML0338, len: 1025 bp. Possible pseudogene similar to M. tuberculosis orthologue Rv3575c (1080 bp) (Best blastx scores: 220) Yes regulatory proteins Rv3575c Rv3575c AL450380.2 Mycobrowser_v4 CDS 309643 310899 . - 0 ML0236c pabB Probable para-aminobenzoate synthase component I PabB ML0236c, len: 418 aa. Probable pabB, para-aminobenzoate synthase component I (EC 4.1.3.-), highly similar to Rv1005c|O05591|Z94752 pabB, putative para-aminobenzoate synthase component I from M. tuberculosis (458 aa), Fasta scores: E(): 0, (79.1% identity in 412 aa overlap). Similar to many others e.g. PABB_ECOLI|P05041 pabB, para-aminobenzoate synthase component I from Escherichia coli (453 aa), Fasta scores: E(): 5.5e-31, (35.2% identity in 378 aa overlap). Also similar to the C-terminal halves of ML0808 and ML1269 from M. leprae. When compared to the predicted M. tuberculosis translation, this CDS is missing the N-terminal 30 aa, thus it may be a pseudogene. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. Q7AQL1 No intermediary metabolism and respiration PF00425 Q7AQL1 GO:0009396 Rv1005c Rv1005c AL450380.2 Mycobrowser_v4 CDS 344904 345275 . - 0 ML0264c ML0264c Hypothetical protein (pseudogene) ML0264c, len: 372 bp. Possible pseudogene similar to M. tuberculosis Rv2775 (462 bp) (Best blastx scores: 95) Yes unknown AL450380.2 Mycobrowser_v4 CDS 346709 347435 . + 0 ML0266 ML0266 Conserved hypothetical protein (pseudogene) ML0266, len: 727 bp. Possible pseudogene similar to M. tuberculosis orthologue Rv1056 (765 bp) (Best blastx scores: 289) Yes conserved hypotheticals Rv1056 Rv1056 AL450380.2 Mycobrowser_v4 CDS 350965 351892 . - 0 ML0267c ackA Probable acetate kinase AckA (pseudogene) ML0267c, len: 928 bp. Possible pseudogene of M. tuberculosis orthologue ackA|Rv0409 (1158 bp) (Best blastx scores: 257) Yes intermediary metabolism and respiration Rv0409 Rv0409 AL450380.2 Mycobrowser_v4 CDS 326387 326995 . + 0 ML0250 ML0250 Probable transcriptional regulatory protein (Probably TetR-family) (pseudogene) ML0250, len: 609 bp. Possible pseudogene of M. tuberculosis orthologue Rv1019 (594 bp) (Best blastx scores: 404) Yes regulatory proteins Rv1019 Rv1019 AL450380.2 Mycobrowser_v4 CDS 327120 327945 . - 0 ML0251c ML0251c Probable diaminopimelate decarboxylase (pseudogene) ML0251c, len: 829 bp. Possible pseudogene similar to M. tuberculosis lysA|Rv1293 (1341 bp) (Best blastx scores: 114), also similar to ML1128 a possible orthologue of M. tuberculosis lysA. Yes unknown AL450380.2 Mycobrowser_v4 CDS 331780 332529 . + 0 ML0253 ML0253 Conserved hypothetical protein (pseudogene) ML0253, len: 750 bp. Possible pseudogene of M. tuberculosis orthologue Rv1021 (978 bp) (Best blastx scores: 252). Yes conserved hypotheticals Rv1021 Rv1021 AL450380.2 Mycobrowser_v4 tRNA 2292908 2292980 . - 0 MLP000035 trpT tRNA-Trp anticodon CCA tRNA Trp anticodon CCA, Cove scores: 79.38 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 395182 397023 . - 0 ML0309c ML0309c Putative conserved ATPase (pseudogene) ML0309c, len: 1842 bp. Possible pseudogene of M. tuberculosis orthologue Rv0435c (2187 bp) (Best blastx scores: 329) Yes cell wall and cell processes Rv0435c Rv0435c AL450380.2 Mycobrowser_v4 CDS 369473 369612 . + 0 ML0288 ML0288 Possible transposase remnant (pseudogene) ML0288, len: 140 bp. Possible transposase remnant, some similarity to Q9RBZ3 transposase from Pseudomonas syringae (1071 bp), (blastx scores: 51) and to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 41). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 332923 333664 . + 0 ML0254 lpqU Probable conserved lipoprotein LpqU (pseudogene) ML0254, len: 742 bp. Possible pseudogene of M. tuberculosis orthologue lpqU|Rv1022 (732 bp) (Best blastx scores: 224) Yes cell wall and cell processes Rv1022 Rv1022 AL450380.2 Mycobrowser_v4 CDS 337531 339287 . + 0 ML0259 ML0259 Probable conserved transmembrane transport protein (pseudogene) ML0259, len: 1757 bp. Possible pseudogene similar to M. tuberculosis mmpL4|Rv0450c (2904 bp) (Best blastx scores: 308), also similar to ML2378 a possible orthologue of M. tuberculosis mmpL4. Yes unknown AL450380.2 Mycobrowser_v4 CDS 351893 352999 . - 0 ML0268c pta Probable phosphate acetyltransferase Pta (pseudogene) ML0268c, len: 1107 bp. Possible pseudogene of M. tuberculosis orthologue pta|Rv0408 (2073 bp) (Best blastx scores: 310). Yes intermediary metabolism and respiration Rv0408 Rv0408 AL450380.2 Mycobrowser_v4 CDS 355303 355922 . + 0 ML0272 ML0272 Probable short-chain dehydrogenase/reductase (pseudogene) ML0272, len: 620 bp. Possible short-chain dehydrogenase/reductase pseudogene. Similar to several M. tuberculosis genes e.g. Rv1941, Rv2214c, Rv2857c (Best blastx scores: 134). Yes unknown AL450380.2 Mycobrowser_v4 CDS 355941 356489 . + 0 ML0273 fadE7 Acyl-CoA dehydrogenase FadE7 (pseudogene) ML0273, len: 549 bp. Possible pseudogene of M. tuberculosis orthologue fadE7|Rv0400c (1188 bp) (Best blastx scores: 140). Yes lipid metabolism Rv0400c Rv0400c AL450380.2 Mycobrowser_v4 CDS 356520 356618 . + 0 ML0274 ML0274 Possible secreted protein (pseudogene) ML0274, len: 99 bp. Possible pseudogene of M. tuberculosis orthologue Rv0398c (642 bp) (Best blastx scores: 86) Yes cell wall and cell processes Rv0398c Rv0398c AL450380.2 Mycobrowser_v4 CDS 360202 360638 . + 0 ML0277 PPE PPE-family protein (pseudogene) ML0277, len: 437 bp. Possible pseudogene of M. tuberculosis orthologue PPE9|Rv0388c (543 bp) (Best blastx scores: 74) Yes PE/PPE Rv0388c Rv0388c AL450380.2 Mycobrowser_v4 tRNA 12194 12270 . + 0 MLP000001 ileT tRNA-Ile anticodon GAT tRNA Ile anticodon GAT, Cove scores: 88.84 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 345708 345920 . + 0 ML0265 ML0265 Hypothetical protein ML0265, len: 70 aa. Hypothetical protein. Improbable CDS suggested by GC frameplot. Possibly the remains of a disrupted gene. Q7AQK9 No unknown Q7AQK9 AL450380.2 Mycobrowser_v4 CDS 428888 429250 . - 0 ML0339c ML0339c Transcriptional regulatory protein (probably TetR-family) (pseudogene) ML0339c, len: 363 bp. Possible pseudogene of M. tuberculosis orthologue Rv3574 (600 bp) (Best blastx scores: 269) Yes regulatory proteins Rv3574 Rv3574 AL450380.2 Mycobrowser_v4 CDS 61406 61693 . - 0 ML0049c esxA Probable 6 kDa early secretory antigenic target homolog EsxA (ESAT-6-like protein) (L-ESAT) ML0049c, len: 95 aa. Probable esxA, 6 KDa early secretory antigenic target homolog (see citations below). Similar to Rv3875|ESA6_MYCTU|Q57165 esxA, early secretory antigenic target from M. tuberculosis (94 aa), Fasta scores: E(): 4.2e-10, (36.3% identity in 91 aa overlap). Also shows weak similarity to others e.g. CFP7_MYCTU|O53693 esxH, 10 KDa antigen from M. tuberculosis (95 aa), Fasta scores: E(): 0.17, (25.6% identity in 78 aa overlap). Other members of this family include ML0363. Previously sequenced as ESA6_MYCLE|Q50206 (95 aa), Fasta scores: E(): 0, (100.0% identity in 95 aa overlap). Belongs to the ESAT6 family. Note that previously known as esat-6. Q50206 No cell wall and cell processes PF06013 Q50206 GO:0005576 Rv3875 Rv3875 AL450380.2 Mycobrowser_v4 CDS 398721 399954 . - 0 ML0312c moeA2 Probable molybdenum cofactor biosynthesis protein MoeA2 (pseudogene) ML0312c, len: 1234 bp. Possible pseudogene of M. tuberculosis orthologue moeA2|Rv0438c (1218 bp) (Best blastx scores: 245). Note that previously known as moeA3. Yes intermediary metabolism and respiration Rv0438c Rv0438c AL450380.2 Mycobrowser_v4 CDS 968481 969134 . - 0 ML0820c lipV Probable lipase LipV (pseudogene) ML0820c, len: 654 bp. Possible pseudogene of M. tuberculosis orthologue lipV|Rv3203 (675 bp) (Best blastx scores: 236). Yes intermediary metabolism and respiration Rv3203 Rv3203 AL450380.2 Mycobrowser_v4 tRNA 1481451 1481524 . - 0 MLP000020 argW tRNA-Arg anticodon TCT tRNA Arg anticodon TCT, Cove scores: 69.26 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 1638370 1638446 . + 0 MLP000027 proT tRNA-Pro anticodon GGG tRNA Pro anticodon GGG, Cove scores: 80.45 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 1785017 1785093 . - 0 MLP000028 proU tRNA-Pro anticodon TGG tRNA Pro anticodon TGG, Cove scores: 89.79 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2294807 2294883 . - 0 MLP000036 metT tRNA-Met anticodon CAT tRNA Met anticodon CAT, Cove scores: 89.68 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2294937 2295009 . - 0 MLP000037 thrT tRNA-Thr anticodon GGT tRNA Thr anticodon GGT, Cove scores: 79.74 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2506608 2506680 . + 0 MLP000038 argT tRNA-Arg anticodon CCT tRNA Arg anticodon CCT, Cove scores: 73.39 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2594690 2594766 . - 0 MLP000040 aspT tRNA-Asp anticodon GTC tRNA Asp anticodon GTC, Cove scores: 87.88 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2659699 2659773 . + 0 MLP000043 thrV tRNA-Thr anticodon TGT tRNA Thr anticodon TGT, Cove scores: 85.47 No stable RNAs AL450380.2 Mycobrowser_v4 tRNA 2707392 2707475 . + 0 MLP000044 tyrT tRNA-Tyr anticodon GTA tRNA Tyr anticodon GTA, Cove scores: 59.73 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 323092 323406 . - 0 ML0247c arsC Reduction of arsenate [AS(V)] to arsenite [AS(III)]. this protein expands the substrate specificity of arsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [Catalytic activity: Arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin]. Possible arsenate reductase ArsC ML0247c, len: 104 aa. Possible arsC, arsenate reductase, similar to several others e.g. ARC1_ECOLI|P08692 arsC, arsenate reductase from Escherichia coli (141 aa), Fasta scores: E(): 1.7e-07, (38.8% identity in 103 aa overlap). Q9CD46 No virulence, detoxification, adaptation Q9CD46 GO:0016491 AL450380.2 Mycobrowser_v4 CDS 264898 265101 . + 0 ML0198 cspA Probable cold shock protein A CspA ML0198, len: 67 aa. Probable cspA, cold shock protein A, identical to Rv3648c|CSPA_MYCTU|O06360 probable cspA, cold shock protein A from M. tuberculosis (67 aa), Fasta scores: E(): 3.9e-27, (97.0% identity in 67 aa overlap). Similar to many others e.g. CSP_ARTGO|P54584 csp, cold shock protein from Arthrobacter globiformis (67 aa), Fasta scores: E(): 8.8e-19, (71.6% identity in 67 aa overlap). Previously sequenced as O69550|AL023093 (67 aa), Fasta scores: E(): 1.2e-27, (100.0% identity in 67 aa overlap). Also similar to ML2147 from M. leprae. Contains Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain. Contains PS00352 'Cold-shock' DNA-binding domain signature. O69550 No virulence, detoxification, adaptation PF00313 O69550 GO:0005737,GO:0006355,GO:0003677 Rv3648c Rv3648c AL450380.2 Mycobrowser_v4 CDS 1 1566 . + 0 ML0001 dnaA Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (DNAA BOX): 5'-TTATC(C/A)A(C/A)A-3'. DNAA binds to ATP and to acidic phospholipids. Probable chromosomal replication initiator protein DnaA ML0001, len: 521 aa. Probable dnaA, chromosomal replication initiator protein (see citations below), highly similar to other Mycobacterial chromosomal replication initiator proteins e.g. Rv0001|DNAA_MYCTU|P49993 from M. tuberculosis (507 aa), Fasta scores: E(): 0, (87.2% identity in 507 aa overlap); and DNAA_MYCSM|P49992 from M. smegmatis (495 aa), Fasta scores: E(): 0, (69.2% identity in 441 aa overlap). Previously sequenced as DNAA_MYCLE|P46388 (521 aa), Fasta scores: E(): 0, (99.8% identity in 521 aa overlap). Contains Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA protein. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS01008 DnaA protein signature. Belongs to the DnaA family. Note that the first base of this gene has been taken as base 1 of the Mycobacterium leprae genomic sequence. P46388 No information pathways PF00308,PF08299 P46388 GO:0006270,GO:0003688,GO:0005737,GO:0017111,GO:0006275,GO:0005524 Rv0001 Rv0001 AL450380.2 Mycobrowser_v4 CDS 976029 977055 . + 0 ML0823 ML0823 Possible transmembrane cation transporter (pseudogene) ML0823, len: 1027 bp. Possible pseudogene of M. tuberculosis orthologue Rv3200c (1068 bp) (Best blastx scores: 571). Yes cell wall and cell processes Rv3200c Rv3200c AL450380.2 Mycobrowser_v4 tRNA 2736804 2736877 . + 0 MLP000045 proY tRNA-Pro anticodon CGG tRNA Pro anticodon CGG, Cove scores: 75.56 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 392397 393160 . + 0 ML0306 ML0306 Possible conserved membrane protein (pseudogene) ML0306, len: 764 bp. Possible pseudogene of M. tuberculosis orthologue Rv0538 (1647 bp) (Best blastx scores: 184) Yes cell wall and cell processes Rv0538 Rv0538 AL450380.2 Mycobrowser_v4 CDS 333751 335094 . + 0 ML0255 eno Probable enolase Eno (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase) ML0255, len: 447 aa. Probable eno, enolase (EC 4.2.1.11), highly similar to Rv1023|ENO_MYCTU|P96377 eno, probable enolase from M. tuberculosis (429 aa), Fasta scores: E(): 0, (88.8% identity in 429 aa overlap). Similar to many others e.g. ENO_BACSU|P37869 eno, enolase (2-phosphoglycerate dehydratase) from Bacillus subtilis (430 aa), Fasta scores: E(): 0, (58.8% identity in 425 aa overlap). Contains Pfam match to entry PF00113 enolase, Enol-ase. Contains PS00164 Enolase signature. Magnesium is required for catalysis and for stabilizing the dimer. Belongs to the enolase family. Q9CD42 No intermediary metabolism and respiration PF00113,PF03952 Q9CD42 GO:0005576,GO:0006096,GO:0000287,GO:0004634,GO:0000015,GO:0009986 4.2.1.11 Rv1023 Rv1023 AL450380.2 Mycobrowser_v4 CDS 456419 456733 . + 0 ML0363 esxT PUTATIVE ESAT-6 LIKE PROTEIN ESXT ML0363, len: 104 aa. Possible esxT, Esat-6 like protein. Similar to M. tuberculosis Rv3444c, esat6-family protein, TR:O06261 (EMBL:Al123456) (100 aa), Fasta scores: E(): 3.3e-20, 71.2% identity in 73 aa overlap and others of the esat6 family e.g. esat6 itself, 6 kDa early secretory antigenic target, SW:ESA6_MYCTU (Q57165) (94 aa), Fasta scores: E(): 1.5, 28.4% identity in 67 aa overlap. Q9CCV7 No cell wall and cell processes PF06013 Q9CCV7 Rv3444c Rv3444c AL450380.2 Mycobrowser_v4 CDS 1473958 1475002 . + 0 ML1236 pks11 Possible chalcone synthase Pks11 (pseudogene) ML1236, len: 1045 bp. Possible pseudogene of M. tuberculosis orthologue pks11|Rv1665 (1062 bp) (Best blastx scores: 356). Yes lipid metabolism Rv1665 Rv1665 AL450380.2 Mycobrowser_v4 CDS 539671 540205 . + 0 ML0439 ML0439 Possible oxidase regulatory-related protein (pseudogene) ML0439, len: 535 bp. Possible pseudogene of M. tuberculosis orthologue Rv2499c (558 bp) (Best blastx scores: 164) Yes intermediary metabolism and respiration Rv2499c Rv2499c AL450380.2 Mycobrowser_v4 CDS 540205 540783 . + 0 ML0440 citE Probable citrate (pro-3S) lyase [beta subunit] CitE (pseudogene) ML0440, len: 579 bp. Possible pseudogene of M. tuberculosis orthologue citE|Rv2498c (822 bp) (Best blastx scores: 389) Yes intermediary metabolism and respiration Rv2498c Rv2498c AL450380.2 Mycobrowser_v4 CDS 324556 326034 . - 0 ML0249c glmU Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU ML0249c, len: 492 aa. Probable glmU, UDP-n-acetylglucosamine pyrophosphorylase (EC 2.7.7.23), highly similar to Rv1018c|P96382|AL123456 glmU, probable UDP-N-acetylglucosamine pyrophosphorylase from M. tuberculosis (495 aa), Fasta scores: E(): 0, (82.1% identity in 492 aa overlap). Similar to many others e.g. GLMU_NEIGO|Q50986 glmU, UDP-N-acetylglucosamine pyrophosphorylase from Neisseria gonorrhoeae (456 aa), Fasta scores: E(): 0, (37.4% identity in 462 aa overlap). Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Contains 5 Pfam matches to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats). Q9CD44 No cell wall and cell processes PF00132,PF01128 Q9CD44 GO:0000902,GO:0007047,GO:0005737,GO:0019134,GO:0008299,GO:0009103,GO:0000287,GO:0009252,GO:0008360,GO:0003977 2.3.1.157,2.7.7.23 Rv1018c Rv1018c AL450380.2 Mycobrowser_v4 CDS 1522332 1523603 . + 0 ML1279 ML1279 Conserved membrane protein (pseudogene) ML1279, len: 1272 bp. Possible pseudogene of M. tuberculosis orthologue Rv1619 (1455 bp) (Best blastx scores: 351). Yes cell wall and cell processes Rv1619 Rv1619 AL450380.2 Mycobrowser_v4 CDS 149361 150125 . - 0 ML0108c ML0108c Probable short-chain type dehydrogenase/reductase ML0108c, len: 254 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to Rv3791|Y1J1_MYCTU|P72057 short-chain dehydrogenase/reductase from M. tuberculosis (254 aa), Fasta scores: E(): 0, (89.0% identity in 254 aa overlap); and to other Mycobacterial putative oxidoreductases. Also similar to Q9KZA5 putative short-chain dehydrogenase from Streptomyces coelicolor A3(2) (256 aa), Fasta scores: E(): 3.2e-41, (44.8% identity in 254 aa overlap). Shows weaker similarity to PHBB_ALCEU|P14697 phbB, acetoacetyl-CoA reductase from Alcaligenes eutrophus (246 aa), Fasta scores: E(): 3e-09, (28.3% identity in 191 aa overlap). Also shows weak similarity to ML0429 and to the C-terminal half of ML2565 from M. leprae. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenase/reductase (SDR) family. Q9CDA5 No intermediary metabolism and respiration, lipid metabolism PF00106 Q9CDA5 GO:0008152,GO:0016491,GO:0005488 Rv3791 Rv3791 AL450380.2 Mycobrowser_v4 CDS 250221 251249 . + 0 ML0185 ML0185 Probable conserved transmembrane protein ML0185, len: 342 aa. Probable conserved transmembrane protein, highly similar to Rv0996|O05579|AL123456 conserved transmembrane protein from M.tuberculosis (358 aa), Fasta scores: E(): 0, (66.4% identity in 360 aa overlap). Previously sequenced as Q9Z5F8|AL035500 (342 aa), Fasta scores: E(): 0, (100.0% identity in 342 aa overlap). Contains possible signal sequence and other hydrophobic domains. Q7AQM6 No cell wall and cell processes Q7AQM6 Rv0996 Rv0996 AL450380.2 Mycobrowser_v4 CDS 450364 451274 . - 0 ML0356c fadE27 Probable acyl-CoA dehydrogenase FadE27 (pseudogene) ML0356c, len: 911 bp. Possible pseudogene of M. tuberculosis orthologue fadE27|Rv3505 (1122 bp) (Best blastx scores: 223) Yes lipid metabolism Rv3505 Rv3505 AL450380.2 Mycobrowser_v4 CDS 452647 452817 . + 0 ML0358 fdxD Probable ferredoxin FdxD (pseudogene) ML0358, len: 171 bp. Possible pseudogene of M. tuberculosis orthologue fdxD|Rv3503c (192 bp) (Best blastx scores: 212) Yes intermediary metabolism and respiration Rv3503c Rv3503c AL450380.2 Mycobrowser_v4 CDS 299138 300436 . + 0 ML0228 ML0228 Probable conserved transmembrane protein rich in alanine, arginine and proline ML0228, len: 432 aa. Probable conserved ala-, arg-, pro-rich transmembrane protein, similar to Rv3604c|O06278|AL123456 ala-, arg-, pro-rich transmembrane protein from M. tuberculosis (397 aa), Fasta scores: E(): 0, (59.7% identity in 432 aa overlap). Previously sequenced as O69526|AL023093 (432 aa), Fasta scores: E(): 0, (100.0% identity in 432 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQL3 No cell wall and cell processes Q7AQL3 Rv3604c Rv3604c AL450380.2 Mycobrowser_v4 CDS 451303 452425 . - 0 ML0357c fadE26 Probable acyl-CoA dehydrogenase FadE26 (pseudogene) ML0357c, len: 1123 bp. Possible pseudogene of M. tuberculosis orthologue fadE26|Rv3504 (1203 bp) (Best blastx scores: 551) Yes lipid metabolism Rv3504 Rv3504 AL450380.2 Mycobrowser_v4 CDS 454076 454786 . + 0 ML0360 yrbE4A Conserved hypothetical unknown integral membrane protein, part of mce4 operon YrbE4A (pseudogene) ML0360, len: 711 bp. Possible pseudogene of M. tuberculosis orthologue Rv3501c|yrbE4A (765 bp) (Best blastx scores: 493) Yes virulence, detoxification, adaptation Rv3501c Rv3501c AL450380.2 Mycobrowser_v4 CDS 1121896 1122135 . + 0 ML0953 ML0953 hypothetical protein ML0953, len: 79 aa. Hypothetical unknown protein. Q9CCC9 No unknown Q9CCC9 AL450380.2 Mycobrowser_v4 CDS 211150 212814 . - 0 ML0150c pgi Probable glucose-6-phosphate isomerase Pgi (phosphoglucose isomerase) (phosphohexose isomerase) (PHI) ML0150c, len: 554 aa. Probable pgi, glucose-6-phosphate isomerase (EC 5.3.1.9), highly similar to Rv0946c|G6PI_MYCTU|P77895 pgi, glucose-6-phosphate isomerase from M. tuberculosis (553 aa), Fasta scores: E(): 0, (85.5% identity in 552 aa overlap); and to G6PI_MYCSM|P96803 pgi, glucose-6-phosphate isomerase from Mycobacterium smegmatis (442 aa), Fasta scores: E(): 0, (84.1% identity in 440 aa overlap). Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. Belongs to the GPI family. Q9CD75 No intermediary metabolism and respiration PF00342 Q9CD75 GO:0006094,GO:0004347,GO:0006096,GO:0005737 5.3.1.9 Rv0946c Rv0946c AL450380.2 Mycobrowser_v4 CDS 224616 226199 . + 0 ML0161 purH Involved in de novo purine biosynthesis (at the ninth and tenth steps) [Catalytiv activity 1: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide] [Catalytiv activity 2: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide]. Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transformylase) and inosinemonophosphatecyclohydrolase (IMP cyclohydrolase) (inosinicase) (IMP synthetase) (ATIC) ML0161, len: 527 aa. Probable purH, bifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase (EC 2.1.2.3) and inosine-monophosphate (IMP) cyclohydrolase (EC 3.5.4.10), highly similar to Rv0957|PUR9_MYCTU|P71553 purH from (523 aa), Fasta scores: E(): 0, (88.1% identity in 520 aa overlap). Similar to many e.g. PUR9_BACSU|P12048 purN, phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase from Bacillus subtilis (512 aa), Fasta scores: E(): 0, (43.2% identity in 519 aa overlap). Previously sequenced as PUR9_MYCLE|Q9Z5H5 (527 aa), Fasta scores: E(): 0, (100.0% identity in 527 aa overlap). Contains Pfam match to entry PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme. Belongs to the PurH family. Q9Z5H5 No intermediary metabolism and respiration PF01808,PF02142 Q9Z5H5 GO:0003937,GO:0004643,GO:0006188 3.5.4.10,2.1.2.3 Rv0957 Rv0957 AL450380.2 Mycobrowser_v4 CDS 485790 486125 . + 0 ML0391 ML0391 Possible transcriptional regulator (pseudogene) ML0391, len: 336 bp. Possible pseudogene of M. tuberculosis orthologue Rv3405c (567 bp) (Best blastx scores: 162) Yes regulatory proteins Rv3405c Rv3405c AL450380.2 Mycobrowser_v4 CDS 400043 400676 . - 0 ML0313c ML0313c Probable dehydrogenase/reductase (pseudogene) ML0313c, len: 634 bp. Possible pseudogene of M. tuberculosis orthologue Rv0439c (936 bp) (Best blastx scores: 248) Yes intermediary metabolism and respiration Rv0439c Rv0439c AL450380.2 Mycobrowser_v4 CDS 408188 409346 . - 0 ML0318c radA Probable DNA repair protein RadA (pseudogene) ML0318c, len: 1159 bp. Possible pseudogene of M. tuberculosis orthologue radA|Rv3585 (1443 bp) (Best blastx scores: 221) Yes information pathways Rv3585 Rv3585 AL450380.2 Mycobrowser_v4 CDS 540803 541461 . + 0 ML0441 pdhA Probable pyruvate dehydrogenase E1 component [alpha subunit] PdhA (pseudogene) ML0441, len: 659 bp. Possible pseudogene of M. tuberculosis orthologue pdhA|Rv2497c (1104 bp) (Best blastx scores: 325) Yes intermediary metabolism and respiration Rv2497c Rv2497c AL450380.2 Mycobrowser_v4 CDS 1431583 1432440 . - 0 ML1211c treY Maltooligosyltrehalose synthase TreY (pseudogene) ML1211c, len: 858 bp. Possible pseudogene of M. tuberculosis orthologue treY|Rv1563c (2298 bp) (Best blastx scores: 368). Yes virulence, detoxification, adaptation Rv1563c Rv1563c AL450380.2 Mycobrowser_v4 CDS 416570 416846 . - 0 ML0326c esxR Low molecular weight protein antigen EsxR (pseudogene) ML0326c, len: 277 bp. Possible pseudogene of M. tuberculosis orthologue Rv3019c|esxR (291 bp) (Best blastx scores: 118) Yes cell wall and cell processes Rv3019c Rv3019c AL450380.2 Mycobrowser_v4 CDS 416867 417153 . - 0 ML0327c esxS Conserved hypothetical protein EsxS (pseudogene) ML0327c, len: 287 bp. Possible pseudogene of M. tuberculosis orthologue Rv3020c|esxS (294 bp) (Best blastx scores: 124). Yes cell wall and cell processes Rv3020c Rv3020c AL450380.2 Mycobrowser_v4 CDS 417243 418419 . - 0 ML0328c PPE PPE-family protein (pseudogene) ML0328c, len: 1177 bp. Possible pseudogene of M. tuberculosis orthologue Rv3021c|PPE47 (1077 bp) (Best blastx scores: 169). Yes PE/PPE Rv3021c Rv3021c AL450380.2 Mycobrowser_v4 CDS 409443 409994 . - 0 ML0319c lpqE Possible lipoprotein LpqE ML0319c, len: 183 aa. Possible lpqE, conserved lipoprotein, highly similar to Rv3584|O53569|AL123456 lpqE, conserved lipoprotein from M. tuberculosis (182 aa), Fasta scores: E(): 0, (63.4% identity in 175 aa overlap). Previously sequenced as Q9ZBM7|AL035159 (183 aa), Fasta scores: E(): 0, (99.5% identity in 183 aa overlap). Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9ZBM7 No cell wall and cell processes Q9ZBM7 GO:0005886 Rv3584 Rv3584 AL450380.2 Mycobrowser_v4 CDS 429654 431496 . + 0 ML0340 fadE34 Probable acyl-CoA dehydrogenase FadE34 (pseudogene) ML0340, len: 1843 bp. Possible pseudogene of M. tuberculosis orthologue fadE34|Rv3573c (2136 bp) (Best blastx scores: 539) Yes lipid metabolism Rv3573c Rv3573c AL450380.2 Mycobrowser_v4 CDS 431728 432219 . - 0 ML0341c ML0341c Hypothetical protein (pseudogene) ML0341c, len: 492 bp. Possible pseudogene of M. tuberculosis orthologue Rv3572 (531 bp) (Best blastx scores: 324) Yes conserved hypotheticals Rv3572 Rv3572 AL450380.2 Mycobrowser_v4 CDS 432324 433324 . - 0 ML0342c hmp Possible hemoglobine-related protein Hmp (pseudogene) ML0342c, len: 1001 bp. Possible pseudogene of M. tuberculosis orthologue Rv3571|hmp (1077 bp) (Best blastx scores: 484) Yes intermediary metabolism and respiration Rv3571 Rv3571 AL450380.2 Mycobrowser_v4 CDS 434747 435271 . + 0 ML0344 bphD Probable 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD (pseudogene) ML0344, len: 525 bp. Possible pseudogene of M. tuberculosis orthologue Rv3569c|bphD (876 bp) (Best blastx scores: 339) Yes intermediary metabolism and respiration Rv3569c Rv3569c AL450380.2 Mycobrowser_v4 CDS 435603 436742 . - 0 ML0345c ltp3 Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3 (pseudogene) ML0345c, len: 1140 bp. Possible pseudogene of M. tuberculosis orthologue Rv3523|ltp3 (1185 bp) (Best blastx scores: 319) Yes lipid metabolism Rv3523 Rv3523 AL450380.2 Mycobrowser_v4 CDS 436784 437195 . - 0 ML0346c ltp4 Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4 (pseudogene) ML0346c, len: 412 bp. Possible pseudogene of M. tuberculosis orthologue Rv3522|ltp4 (1065 bp) (Best blastx scores: 167) Yes lipid metabolism Rv3522 Rv3522 AL450380.2 Mycobrowser_v4 CDS 437392 437982 . - 0 ML0347c ML0347c Conserved hypothetical protein (pseudogene) ML0347c, len: 591 bp. Possible pseudogene of M. tuberculosis orthologue Rv3521 (912 bp) (Best blastx scores: 236) Yes conserved hypotheticals Rv3521 Rv3521 AL450380.2 Mycobrowser_v4 CDS 439394 439705 . - 0 ML0349c ML0349c Hypothetical protein (pseudogene) ML0349c, len: 312 bp. Possible pseudogene of M. tuberculosis orthologue Rv3519 (711 bp) (Best blastx scores: 156) Yes conserved hypotheticals Rv3519 Rv3519 AL450380.2 Mycobrowser_v4 CDS 442416 443186 . - 0 ML0350c ML0350c Possible transferase (pseudogene) ML0350c, len: 771 bp. Possible pseudogene similar to M. tuberculosis Rv3729 (2331 bp) (Best blastx scores: 294) Yes unknown AL450380.2 Mycobrowser_v4 CDS 444088 444738 . - 0 ML0351c echA19 Possible enoyl-CoA hydratase EchA19 (pseudogene) ML0351c, len: 651 bp. Possible pseudogene of M. tuberculosis orthologue echA19|Rv3516 (792 bp) (Best blastx scores: 238) Yes lipid metabolism Rv3516 Rv3516 AL450380.2 Mycobrowser_v4 CDS 444861 445796 . + 0 ML0352 fadD19 Probable fatty-acid-CoA synthetase FadD19 (pseudogene) ML0352, len: 936 bp. Possible pseudogene of M. tuberculosis orthologue fadD19|Rv3515c (1647 bp) (Best blastx scores: 221) Yes lipid metabolism Rv3515c Rv3515c AL450380.2 Mycobrowser_v4 CDS 446610 447406 . + 0 ML0353 ML0353 Conserved hypothetical protein (pseudogene) ML0353, len: 797 bp. Possible pseudogene of M. tuberculosis orthologue Rv3510c (837 bp) (Best blastx scores: 461) Yes conserved hypotheticals Rv3510c Rv3510c AL450380.2 Mycobrowser_v4 CDS 449016 450184 . - 0 ML0355c fadD17 Possible fatty-acid-CoA synthase FadD17 (pseudogene) ML0355c, len: 1169 bp. Possible pseudogene of M. tuberculosis orthologue fadD17|Rv3506 (1509 bp) (Best blastx scores: 515) Yes lipid metabolism Rv3506 Rv3506 AL450380.2 Mycobrowser_v4 CDS 2615455 2615694 . - 0 ML2201c ML2201c hypothetical protein ML2201c, len: 79 aa. Hypothetical unknown protein. Q9CBC5 No unknown Q9CBC5 AL450380.2 Mycobrowser_v4 CDS 454841 455650 . + 0 ML0361 yrbE4B Conserved hypothetical unknown integral membrane protein, part of mce4 operon YrbE4B (pseudogene) ML0361, len: 810 bp. Possible pseudogene of M. tuberculosis orthologue Rv3500c|yrbE4B (843 bp) (Best blastx scores: 393) Yes virulence, detoxification, adaptation Rv3500c Rv3500c AL450380.2 Mycobrowser_v4 CDS 455771 456329 . + 0 ML0362 mce4A Mce-family protein Mce4A (pseudogene) ML0362, len: 559 bp. Possible pseudogene of M. tuberculosis orthologue mce4A|Rv3499c (1203 bp) (Best blastx scores: 195) Yes virulence, detoxification, adaptation Rv3499c Rv3499c AL450380.2 Mycobrowser_v4 CDS 459448 459649 . + 0 ML0367 ML0367 Hypothetical protein (pseudogene) ML0367, len: 202 bp. Possible pseudogene of M. tuberculosis orthologue Rv3440c (312 bp) (Best blastx scores: 104) Yes conserved hypotheticals Rv3440c Rv3440c AL450380.2 Mycobrowser_v4 CDS 459676 460545 . + 0 ML0368 ML0368 Conserved hypothetical alanine and proline rich protein (pseudogene) ML0368, len: 870 bp. Possible pseudogene of M. tuberculosis orthologue Rv3439c (1404 bp) (Best blastx scores: 221) Yes conserved hypotheticals Rv3439c Rv3439c AL450380.2 Mycobrowser_v4 CDS 464952 465074 . - 0 ML0372c ML0372c Conserved hypothetical protein (pseudogene) ML0372c, len: 123 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins e.g. Rv3399 (1047 bp), Rv1729, Rv1889c and Rv0893c etc (Best blastx scores: 137). Yes unknown AL450380.2 Mycobrowser_v4 CDS 466654 468023 . + 0 ML0374 gadB Probable glutamate decarboxylase GadB (pseudogene) ML0374, len: 1370 bp. Possible pseudogene of M. tuberculosis orthologue gadB|Rv3432c (1383 bp) (Best blastx scores: 527) Yes intermediary metabolism and respiration Rv3432c Rv3432c AL450380.2 Mycobrowser_v4 CDS 541507 542533 . + 0 ML0442 pdhB Probable pyruvate dehydrogenase E1 component [beta subunit] PdhB (pseudogene) ML0442, len: 1027 bp. Possible pseudogene of M. tuberculosis orthologue pdhB|Rv2496c (1047 bp) (Best blastx scores: 387) Yes intermediary metabolism and respiration Rv2496c Rv2496c AL450380.2 Mycobrowser_v4 CDS 457425 457886 . + 0 ML0365 rpsI Probable 30S ribosomal protein S9 RpsI ML0365, len: 153 aa. Probable rpsI, ribosomal protein S9, highly similar to Rv3442c|RS9_MYCTU|O06259 rpsI, 30S ribosomal protein S9 from M. tuberculosis (151 aa), Fasta scores: E(): 0, (83.2% identity in 155 aa overlap). Also highly similar to others e.g. Q53875|RS9_STRCO|SC6G4.13 from Streptomyces coelicolor (170 aa). Previously sequenced as RS9_MYCLE|P40828 (153 aa), Fasta scores: E(): 0, (99.3% identity in 153 aa overlap). Contains Pfam match to entry PF00380 Ribosomal_S9, Ribosomal protein S9/S16. Contains PS00360 Ribosomal protein S9 signature. Belongs to the S9P family of ribosomal proteins. P40828 No information pathways PF00380 P40828 GO:0003735,GO:0006412,GO:0005840 Rv3442c Rv3442c AL450380.2 Mycobrowser_v4 CDS 477952 478699 . + 0 ML0385 ML0385 Hypothetical alanine and proline rich protein (pseudogene) ML0385, len: 748 bp. Possible pseudogene of M. tuberculosis orthologue Rv3413c (900 bp) (Best blastx scores: 318) Yes conserved hypotheticals Rv3413c Rv3413c AL450380.2 Mycobrowser_v4 CDS 485209 485601 . - 0 ML0390c ML0390c Probable dioxygenase (pseudogene) ML0390c, len: 393 bp. Possible pseudogene of M. tuberculosis orthologue Rv3406 (888 bp) (Best blastx scores: 382) Yes intermediary metabolism and respiration Rv3406 Rv3406 AL450380.2 Mycobrowser_v4 CDS 580138 580326 . - 0 ML0479c ML0479c Conserved hypothetical protein (pseudogene) ML0479c, len: 189 bp. Possible pseudogene of M. tuberculosis orthologue Rv2598 (495 bp) (Best blastx scores: 204). Yes conserved hypotheticals Rv2598 Rv2598 AL450380.2 Mycobrowser_v4 CDS 580454 581051 . - 0 ML0480c ML0480c Probable membrane protein (pseudogene) ML0480c, len: 598 bp. Possible pseudogene of M. tuberculosis orthologue Rv2597 (621 bp) (Best blastx scores: 175). Yes cell wall and cell processes Rv2597 Rv2597 AL450380.2 Mycobrowser_v4 CDS 469289 470290 . + 0 ML0376 ML0376 Possible membrane protein ML0376, len: 333 aa. Possible membrane protein. Some similarity with O86787 putative lipase from Streptomyces coelicolor A3(2) (420 aa), Fasta scores: E(): 0, (29.0% identity in 286 aa overlap). Contains hydrophobic, possible membrane-spanning region near the N-terminus. Q9CCV4 No cell wall and cell processes Q9CCV4 AL450380.2 Mycobrowser_v4 CDS 471841 472896 . + 0 ML0379 gcp Probable O-sialoglycoprotein endopeptidase Gcp (Glycoprotease) ML0379, len: 351 aa. Probable gcp, glycoprotease (EC 3.4.24.57), highly similar to Rv3419c|GCP_MYCTU|Q50709 gcp, probable O-sialoglycoprotein endopeptidase from M. tuberculosis (344 aa), Fasta scores: E(): 0, (86.1% identity in 345 aa overlap). Similar to other O-sialoglycoprotein endopeptidases e.g. GCP_PASHA|P36175 from Pasteurella haemolytica (325 aa), Fasta scores: E(): 0, (45.8% identity in 319 aa overlap); and O86793|GCP_STRCO|SC6G4.30 from Streptomyces coelicolor (374 aa). Previously sequenced as GCP_MYCLE|P37969 (351 aa), Fasta scores: E(): 0, (100.0% identity in 351 aa overlap). Contains Pfam match to entry PF00814 Peptidase_M22, Glycoprotease family. Contains PS01016 Glycoprotease family signature. Belongs to the Peptidase family M22; also known as the Glycoprotease family. P37969 No intermediary metabolism and respiration PF00814 P37969 GO:0006508,GO:0008270,GO:0004222 3.4.24.57 Rv3419c Rv3419c AL450380.2 Mycobrowser_v4 CDS 544152 545200 . - 0 ML0444c ML0444c Possible group II intron maturase (pseudogene) ML0444c, len: 1049 bp. Possible pseudogene similar to M. tuberculosis Rv0071 (708 bp) (Best blastx scores: 239) Yes unknown AL450380.2 Mycobrowser_v4 CDS 498083 499158 . + 0 ML0400 ML0400 Conserved hypothetical protein (pseudogene) ML0400, len: 1076 bp. Possible pseudogene of M. tuberculosis orthologue Rv3394c (1584 bp) (Best blastx scores: 268) Yes conserved hypotheticals Rv3394c Rv3394c AL450380.2 Mycobrowser_v4 CDS 499304 499756 . - 0 ML0401c ML0401c Probable phosphate transport system transcriptional regulatory protein PhoY2 (pseudogene) ML0401c, len: 453 bp. Possible pseudogene similar to M. tuberculosis phoY2|Rv0821c (642 bp) (Best blastx scores: 152) also similar to ML2188 a possible orthologue of M. tuberculosis phoY2. Yes unknown AL450380.2 Mycobrowser_v4 CDS 499942 500373 . - 0 ML0402c ML0402c Probable serine esterase, cutinase family (pseudogene) ML0402c, len: 432 bp. Possible pseudogene similar to M. tuberculosis Rv1758|cut1 (525 bp) (Best blastx scores: 151) Yes unknown AL450380.2 Mycobrowser_v4 CDS 491044 492633 . + 0 ML0395 guaA Probable GMP synthase [glutamine-hydrolyzing] GuaA (Glutamine amidotransferase) (GMP synthetase) ML0395, len: 529 aa. Probable guaA, gmp synthase (EC 6.3.5.2) (see citation below), highly similar to Rv3396c|GUAA_MYCTU|Q50729 guaA, GMP synthase from M. tuberculosis (525 aa), Fasta scores: E(): 0, (86.9% identity in 525 aa overlap). Also similar to others e.g. GUAA_BACSU|P29727 guaA, GMP synthase [glutamine-hydrolyzing] from Bacillus subtilis (513 aa), Fasta scores: E(): 0, (50.7% identity in 515 aa overlap); and Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa). Previously sequenced as GUAA_MYCLE|P46810 (590 aa), Fasta scores: E(): 0, (100.0% identity in 529 aa overlap). Contains Pfam match to entry PF00958 GMP_synt_C, GMP synthase C terminal domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. Belongs to the type-1 glutamine amidotransferase family in the N-terminal section. And belongs to the GMP synthase family in the C-terminal section. P46810 No intermediary metabolism and respiration PF00117,PF00958,PF03054 P46810 GO:0006177,GO:0003922,GO:0009058,GO:0006541,GO:0005524 6.3.5.2 Rv3396c Rv3396c AL450380.2 Mycobrowser_v4 CDS 506862 507533 . - 0 ML0409c ML0409c Possible IS6110 transposase (pseudogene) ML0409c, len: 672 bp. Possible pseudogene similar to M. tuberculosis IS6110 transposase (Best blastx scores: 164) Yes unknown AL450380.2 Mycobrowser_v4 CDS 555050 555670 . - 0 ML0455c ML0455c Conserved hypothetical protein ML0455c, len: 206 aa. Conserved hypothetical protein, highly similar to Rv2613c|O06201|AL123456 conserved hypothetical protein from M. tuberculosis (195 aa), Fasta scores: E(): 0, (84.7% identity in 196 aa overlap). Similar to many HIT-family hypothetical proteins e.g. Q9L279|SCL2.20 from Streptomyces coelicolor (186 aa), Fasta scores: E(): 0, (84.7% identity in 196 aa overlap); and Q9F7Z0 from Mycobacterium smegmatis (see citation below) (205 aa). Previously sequenced as O07150|Z96801 (186 aa), Fasta scores: E(): 0, (100.0% identity in 186 aa overlap). Contains Pfam match to entry PF01230 HIT, HIT family. In M. tuberculosis it seems the Rv2613c and downstream ORF Rv2612c|psgA1 are expressed from the same promoter (see citation below) and that Rv2613c should be involved in lipid metabolism. Q9CCU0 No lipid metabolism PF01230 Q9CCU0 GO:0003824 Rv2613c Rv2613c AL450380.2 Mycobrowser_v4 CDS 562651 563431 . + 0 ML0465 ML0465 Possible adenylate cyclase (pseudogene) ML0465, len: 781 bp. Possible pseudogene similar to M. tuberculosis (1626 bp), Rv1319c (1608 bp) or Rv1320c (1704 bp) (Best blastx scores: 85) also similar to ML1154c (pseudogene) a possible orthologue of M. tuberculosis of Rv1318c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 567987 569439 . + 0 ML0469 fadD13 Probable fatty-acyl-CoA synthetase (pseudogene) ML0469, len: 1453 bp. Possible pseudogene similar to M. tuberculosis orthologue fadD13|Rv3089 (1512 bp) (Best blastx scores: 97). Yes lipid metabolism Rv3089 Rv3089 AL450380.2 Mycobrowser_v4 CDS 573280 573919 . + 0 ML0471 ML0471 Probable conserved transmembrane protein (pseudogene) ML0471, len: 640 bp. Possible pseudogene similar to M. tuberculosis Rv0051 (1683 bp) also similar to ML2687c a possible orthologue of M. tuberculosis Rv0051. Yes unknown AL450380.2 Mycobrowser_v4 CDS 577203 579168 . - 0 ML0476c speE Probable spermidine synthase SpeE (pseudogene) ML0476c, len: 1966 bp. Possible pseudogene of M. tuberculosis orthologue speE|Rv2601 (1572 bp), interrupted by insertion of an RLEP repeat (Best blastx scores: 229). Yes intermediary metabolism and respiration Rv2601 Rv2601 AL450380.2 Mycobrowser_v4 CDS 579688 580080 . - 0 ML0478c ML0478c Probable conserved membrane protein (pseudogene) ML0478c, len: 393 bp. Possible pseudogene of M. tuberculosis orthologue Rv2599 (432 bp) (Best blastx scores: 115) Yes cell wall and cell processes Rv2599 Rv2599 AL450380.2 Mycobrowser_v4 CDS 561809 562096 . + 0 ML0464 ML0464 hypothetical protein ML0464, len: 95 aa. Hypothetical Unknown protein. Previously sequenced as O07155|Z96801 (110 aa), Fasta scores: E(): 0, (100.0% identity in 95 aa overlap). Q9CCT8 No unknown Q9CCT8 AL450380.2 Mycobrowser_v4 CDS 571604 571894 . - 0 ML0470c ML0470c Hypothetical protein ML0470c, len: 96 aa. Hypothetical unknown protein. Previously sequenced as O07161|Z96801 (96 aa), Fasta scores: E(): 0, (100.0% identity in 96 aa overlap). Q7AQI7 No unknown Q7AQI7 AL450380.2 Mycobrowser_v4 CDS 574539 574811 . + 0 ML0473 ML0473 Hypothetical protein ML0473, len: 90 aa. Hypothetical unknown protein. Improbable CDS suggested by GC frameplot and codon usage plots. Possibly the remains of a disrupted gene. Though similar in part to ML2478 hypothetical unknown protein from M. leprae (129 aa), Fasta scores: E(): 0, (38.2% identity in 55 aa overlap) Q9CCT6 No unknown Q9CCT6 AL450380.2 Mycobrowser_v4 CDS 594986 595505 . + 0 ML0490 apt Probable adenine phosphoribosyltransferase Apt (pseudogene) ML0490, len: 520 bp. Possible pseudogene of M. tuberculosis orthologue apt|Rv2584c (672 bp) (Best blastx scores: 222). Yes intermediary metabolism and respiration Rv2584c Rv2584c AL450380.2 Mycobrowser_v4 CDS 642926 643497 . - 0 ML0529c ML0529c Putative transferase (pseudogene) ML0529c, len: 572 bp. Possible pseudogene of M. tuberculosis orthologue Rv1377c (639 bp) (Best blastx scores: 217). Yes intermediary metabolism and respiration Rv1377c Rv1377c AL450380.2 Mycobrowser_v4 CDS 643653 645021 . - 0 ML0530c ML0530c Conserved hypothetical protein (pseudogene) ML0530c, len: 1369 bp. Possible pseudogene of M. tuberculosis orthologue Rv1378c (1428 bp) (Best blastx scores: 627). Yes conserved hypotheticals Rv1378c Rv1378c AL450380.2 Mycobrowser_v4 CDS 645042 645573 . + 0 ML0531 pyrR Probable pyrimidine operon regulatory protein PyrR (pseudogene) ML0531, len: 532 bp. Possible pseudogene of M. tuberculosis orthologue pyrR|Rv1379 (582 bp) (Best blastx scores: 355) Yes regulatory proteins Rv1379 Rv1379 AL450380.2 Mycobrowser_v4 CDS 621129 621843 . - 0 ML0511c ML0511c Conserved hypothetical protein (pseudogene) ML0511c, len: 715 bp. Possible pseudogene of M. tuberculosis orthologue Rv2558 (711 bp) (Best blastx scores: 199) Yes conserved hypotheticals Rv2558 Rv2558 AL450380.2 Mycobrowser_v4 CDS 601751 602326 . + 0 ML0496 ML0496 Conserved hypothetical protein (pseudogene) ML0496, len: 576 bp. Possible pseudogene of M. tuberculosis orthologue Rv2578c (1023 bp) (Best blastx scores: 339) Yes conserved hypotheticals Rv2578c Rv2578c AL450380.2 Mycobrowser_v4 CDS 602343 603850 . - 0 ML0497c ML0497c Conserved hypothetical protein (pseudogene) ML0497c, len: 1508 bp. Possible pseudogene of M. tuberculosis orthologue Rv2577 (1590 bp) (Best blastx scores: 414). Yes conserved hypotheticals Rv2577 Rv2577 AL450380.2 Mycobrowser_v4 CDS 604111 604426 . + 0 ML0498 ML0498 Possible conserved membrane protein (pseudogene) ML0498, len: 316 bp. Possible pseudogene of M. tuberculosis orthologue Rv2576c (465 bp) (Best blastx scores: 119). Yes cell wall and cell processes Rv2576c Rv2576c AL450380.2 Mycobrowser_v4 CDS 605197 606016 . - 0 ML0499c ML0499c Possible conserved membrane glycine rich protein (pseudogene) ML0499c, len: 820 bp. Possible pseudogene of M. tuberculosis orthologue Rv2575 (882 bp) (Best blastx scores: 329). Yes cell wall and cell processes Rv2575 Rv2575 AL450380.2 Mycobrowser_v4 CDS 606109 606593 . - 0 ML0500c ML0500c Conserved hypothetical protein (pseudogene) ML0500c, len: 485 bp. Possible pseudogene of M. tuberculosis orthologue Rv2573 (741 bp) (Best blastx scores: 211). Yes conserved hypotheticals Rv2573 Rv2573 AL450380.2 Mycobrowser_v4 CDS 599741 601024 . + 0 ML0494 hisS Probable histidyl-tRNA synthase HisS (Histidine--tRNA ligase) (HisRS) (Histidine--Translase) ML0494, len: 427 aa. Probable hisS, histidyl-tRNA synthetase (EC 6.1.1.21), highly similar to SYH_MYCTU|Q50641|Rv2580c hisS, histidyl-tRNA synthase from M. tuberculosis (423 aa), Fasta scores: E(): 9.9e-145, (85.9% identity in 417 aa overlap); and CAD94796|Mb2611c from M. bovis (423 aa). Also highly similar to many e.g. Q9KXP2|HISS from Streptomyces coelicolor (425 aa), FASTA scores: ; SYH_ECOLI|P04804 hisS, histidyl-tRNA synthase from Escherichia coli (423 aa), Fasta scores: (42.1% identity in 413 aa overlap). Previously sequenced as SYH_MYCLE|P46696 (427 aa), Fasta scores: E(): 0, (99.5% identity in 427 aa overlap). Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Belongs to the class-II aminoacyl-tRNA synthetase family. P46696 No information pathways PF00587,PF03129 P46696 GO:0005737,GO:0004821,GO:0006427,GO:0005524 6.1.1.21 Rv2580c Rv2580c AL450380.2 Mycobrowser_v4 CDS 647833 648322 . + 0 ML0534 ML0534 Possible export or membrane protein (pseudogene) ML0534, len: 490 bp. Possible pseudogene of M. tuberculosis orthologue Rv1382 (498 bp) (Best blastx scores: 331). Yes cell wall and cell processes Rv1382 Rv1382 AL450380.2 Mycobrowser_v4 CDS 846401 847611 . + 0 ML0708 amiB1 Probable aminohydrolase AmiB1 (pseudogene) ML0708, len: 1211 bp. Possible pseudogene of M. tuberculosis orthologue amiB1|Rv3306c (1185 bp) (Best blastx scores: 355). Yes intermediary metabolism and respiration Rv3306c Rv3306c AL450380.2 Mycobrowser_v4 CDS 624887 625441 . + 0 ML0513 ML0513 Conserved hypothetical protein ML0513, len: 184 aa. Conserved hypothetical protein, highly similar to YP54_MYCTU|P94999|Rv2554c conserved hypothetical protein from M. tuberculosis (170 aa), Fasta scores: E(): 5.1e-40, (72.0% identity in 161 aa overlap); and CAD94769|Mb2584c from M. bovis (170 aa). Similar to many bacterial hypothetical proteins e.g. Q9KXQ0|SC9C5.24C hypothetical protein from Streptomyces coelicolor (167 aa), Fasta scores: E(): 8.9e-25, (54.8% identity in 155 aa overlap). Q9CCS9 No conserved hypotheticals PF03652 Q9CCS9 GO:0006310,GO:0006281,GO:0005737,GO:0004518,GO:0000150,GO:0003677 3.1.-.- Rv2554c Rv2554c AL450380.2 Mycobrowser_v4 CDS 638095 638980 . - 0 ML0526c ML0526c Probable oxidoreductase (pseudogene) ML0526c, len: 886 bp. Possible pseudogene similar to M. tuberculosis Rv1260 (1119 bp) (Best blastx scores: 110). Yes unknown AL450380.2 Mycobrowser_v4 CDS 641811 642796 . - 0 ML0528c ML0528c Conserved hypothetical protein (pseudogene) ML0528c, len: 986 bp. Possible pseudogene of M. tuberculosis orthologue Rv1367c (1134 bp) (Best blastx scores: 289) Yes conserved hypotheticals Rv1367c Rv1367c AL450380.2 Mycobrowser_v4 CDS 639679 639933 . - 0 ML0527c ML0527c Hypothetical protein ML0527c, len: 84 aa. Hypothetical protein. Q9CCR6 No unknown Q9CCR6 AL450380.2 Mycobrowser_v4 CDS 631822 632952 . + 0 ML0521 pepQ Probable cytoplasmic peptidase PepQ ML0521, len: 376 aa. Probable pepQ, cytoplasmic peptidase (EC 3.4.-.-), highly similar to P95018|AL123456|Rv2535c pepQ, putative cytoplasmic peptidase from M. tuberculosis (372 aa), Fasta scores: E(): 0, (83.0% identity in 376 aa overlap); and CAD94749|Mb2564c from M. bovis (372 aa). Similar to many e.g. P54518|YQHT_BACSU Putative peptidase yqhT from Bacillus subtilis (353 aa), FASTA scores: E(): 3.5e-42, (40.111% identity in 359 aa overlap). Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24. Contains PS00491 Aminopeptidase P and proline dipeptidase signature. Contains PS00211 ABC transporters family signature. Possibly belongs to the peptidase family M24B. Q9CCS1 No intermediary metabolism and respiration PF00557,PF01321 Q9CCS1 GO:0008235,GO:0006508,GO:0004177 Rv2535c Rv2535c AL450380.2 Mycobrowser_v4 CDS 637493 637669 . + 0 ML0525 ML0525 Conserved hypothetical protein ML0525, len: 58 aa. Conserved hypothetical protein, weakly similar to O53218|AL123456|Rv2493 conserved hypothetical protein from M. tuberculosis (73 aa), Fasta scores: E(): 0.15, (47.7% identity in 44 aa overlap); and CAD94744|Mb2521 from M. bovis (73 aa). Q9CCR7 No conserved hypotheticals Q9CCR7 AL450380.2 Mycobrowser_v4 CDS 684846 686399 . + 0 ML0567 ML0567 Conserved membrane protein (pseudogene) ML0567, len: 1554 bp. Possible pseudogene of M. tuberculosis orthologue Rv1431 (1770 bp) (Best blastx scores: 550). Yes cell wall and cell processes Rv1431 Rv1431 AL450380.2 Mycobrowser_v4 CDS 691277 691439 . + 0 ML0568B ML0568B Probable transposase (pseudogene) ML0568B, len: 163 bp. Possible pseudogene similar to several M. tuberculosis transposases associated with IS6110 (Best blastx scores: 75) and identical to ML1291c, ML1242A, ML0599A, ML1820A from M. leprae. Yes unknown AL450380.2 Mycobrowser_v4 CDS 666225 667067 . - 0 ML0549c ML0549c Putative methyltransferase (pseudogene) ML0549c, len: 843 bp. Possible pseudogene of M. tuberculosis orthologue Rv1403c (825 bp) (Best blastx scores: 822). Yes intermediary metabolism and respiration Rv1403c Rv1403c AL450380.2 Mycobrowser_v4 CDS 847646 848748 . + 0 ML0709 amiA1 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (pseudogene) ML0709, len: 1103 bp. Possible pseudogene of M. tuberculosis orthologue amiA1|Rv3305c (1170 bp) (Best blastx scores: 489). Yes intermediary metabolism and respiration Rv3305c Rv3305c AL450380.2 Mycobrowser_v4 CDS 1421621 1422381 . + 0 ML1205 ML1205 Possible ketoacyl reductase (pseudogene) ML1205, len: 761 bp. Possible pseudogene of M. tuberculosis orthologue Rv1544 (804 bp) (Best blastx scores: 215). Also similar to ML2488 a possible pseudogene similar to M. tuberculosis Rv1544. Yes lipid metabolism Rv1544 Rv1544 AL450380.2 Mycobrowser_v4 CDS 670029 671363 . + 0 ML0553 fmu Probable Fmu protein (Sun protein)(pseudogene) ML0553, len: 1335 bp. Possible pseudogene of M. tuberculosis orthologue fmu|Rv1407 (1374 bp) (Best blastx scores: 1324). Yes information pathways Rv1407 Rv1407 AL450380.2 Mycobrowser_v4 CDS 669004 669960 . + 0 ML0552 fmt MODIFIES THE FREE AMINO GROUP OF THE AMINOACYL MOIETY OF METHIONYL-TRNA(FMET). THE FORMYL GROUP APPEARS TO PLAY A DUAL ROLE IN THE INITIATOR IDENTITY OF N-FORMYLMETHIONYL-TRNA BY:(I) PROMOTING ITS RECOGNITION BY IF2 AND (II) IMPAIRING ITS BINDING TO EFTU-GTP. [CATALYTIC ACTIVITY : 10-FORMYLTETRAHYDROFOLATE + L-METHIONYL-TRNA + H(2)O = TETRAHYDROFOLATE + N-FORMYLMETHIONYL-TRNA] Probable methionyl-tRNA formyltransferase Fmt ML0552, len: 318 aa. Probable fmt, methionyl-tRNA formyltransferase (EC 2.1.2.9), highly similar to FMT_MYCTU|P71674|Rv1406 Probable fmt, methionyl-tRNA formyltransferase from M. tuberculosis (312 aa), Fasta scores: E(): 0, (81.0% identity in 316 aa overlap). Similar to many e.g. Q9L0Y6|FMT_STRCO Methionyl-tRNA formyltransferase from Streptomyces coelicolor (310 aa), fasta scores: E(): 4.7e-63, (57.962% identity in 314 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. Belongs to the Fmt family. Q9CCQ0 No information pathways PF00551,PF02911 Q9CCQ0 GO:0006412,GO:0004479 2.1.2.9 Rv1406 Rv1406 AL450380.2 Mycobrowser_v4 CDS 683867 684276 . + 0 ML0566 ML0566 Conserved hypothetical protein (pseudogene) ML0566, len: 410 bp. Possible pseudogene of M. tuberculosis orthologue Rv1425 (1380 bp) (Best blastx scores: 264) Yes lipid metabolism Rv1425 Rv1425 AL450380.2 Mycobrowser_v4 CDS 740724 741532 . - 0 ML0608c ML0608c Conserved hypothetical protein (pseudogene) ML0608c, len: 809 bp. Possible pseudogene of M. tuberculosis orthologue Rv2407 (822 bp) (Best blastx scores: 558). Q49744 Yes conserved hypotheticals Q49744 GO:0008033,GO:0008270,GO:0042781 3.1.26.11 Rv2407 Rv2407 AL450380.2 Mycobrowser_v4 CDS 741779 741992 . + 0 ML0609 ML0609 Conserved hypothetical protein (pseudogene) ML0609, len: 214 bp. Possible pseudogene of M. tuberculosis orthologue Rv2406c (429 bp) (Best blastx scores: 134). Yes conserved hypotheticals Rv2406c Rv2406c AL450380.2 Mycobrowser_v4 CDS 742053 742615 . - 0 ML0610c ML0610c Conserved hypothetical protein (pseudogene) ML0610c, len: 563 bp. Possible pseudogene of M. tuberculosis orthologue Rv2405 (570 bp) (Best blastx scores: 219) Yes conserved hypotheticals Rv2405 Rv2405 AL450380.2 Mycobrowser_v4 CDS 697928 698203 . + 0 ML0573 ML0573 Hypothetical protein ML0573, len: 91 aa. Hypothetical protein. Previously sequenced as Q49684|U00013 (91 aa), Fasta scores: E(): 0, (98.9% identity in 91 aa overlap). Contains Pfam match to entry PF00121 TIM, Triosephosphate isomerase. Q7AQI5 No unknown Q7AQI5 AL450380.2 Mycobrowser_v4 CDS 698200 698517 . + 0 ML0574 ML0574 Hypothetical protein ML0574, len: 105 aa. Hypothetical protein. Previously sequenced as Q49680|U00013 (105 aa), Fasta scores: E(): 0, (99.0% identity in 105 aa overlap). Q7AQI4 No unknown Q7AQI4 AL450380.2 Mycobrowser_v4 CDS 698675 698893 . + 0 ML0575 ML0575 Hypothetical protein ML0575, len: 72 aa. Hypothetical protein. Q9CCN6 No unknown Q9CCN6 AL450380.2 Mycobrowser_v4 CDS 699709 699939 . + 0 ML0576 ML0576 Hypothetical protein ML0576, len: 76 aa. Hypothetical protein. Previously sequenced as Q49681|U00013 (76 aa), Fasta scores: E(): 1.5e-31, (100.0% identity in 76 aa overlap). Q7AQI3 No unknown Q7AQI3 AL450380.2 Mycobrowser_v4 CDS 682780 683757 . + 0 ML0565 whiA Probable transcriptional regulatory protein WhiA ML0565, len: 325 aa. Putative whiA, transcriptional regulatory protein, highly similar to P71692|AL123456|Rv1423 Putative whiA, transcriptional regulator from M. tuberculosis (325 aa), Fasta scores: E(): 9.5e-114, (92.0% identity in 325 aa overlap); and CAD94319|Mb1458 from M. bovis (325 aa). Similar to Q9S4Y1|AF106003 whiA, sporulation regulatory protein from Streptomyces coelicolor (330 aa), Fasta scores: E(): 5.5e-85, (67.6% identity in 324 aa overlap). Q9CCN8 No regulatory proteins PF02650,PF10298 Q9CCN8 Rv1423 Rv1423 AL450380.2 Mycobrowser_v4 CDS 704919 706435 . - 0 ML0581c zwf2 Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (pseudogene) ML0581c, len: 1517 bp. Possible pseudogene of M. tuberculosis orthologue zwf2|Rv1447c (1545 bp) (Best blastx scores: 638). Yes intermediary metabolism and respiration Rv1447c Rv1447c AL450380.2 Mycobrowser_v4 CDS 710905 711811 . - 0 ML0585c qor Probable quinone reductase Qor (pseudogene) ML0585c, len: 907 bp. Possible pseudogene of M. tuberculosis orthologue qor|Rv1454c (987 bp) (Best blastx scores: 228) Yes intermediary metabolism and respiration Rv1454c Rv1454c AL450380.2 Mycobrowser_v4 CDS 704002 704799 . - 0 ML0580c opcA Putative OxPP cycle protein OpcA ML0580c, len: 265 aa. Putative opcA, OxPP cycle protein, highly similar to O06813|AL123456|Rv1446c Putative opcA, OxPP cycle protein from M. tuberculosis (303 aa), Fasta scores: E(): 8.5e-66, (70.3% identity in 239 aa overlap); and CAD96148|Mb1481c from M. bovis (303 aa). Similar to Q8FT73 Putative oxppcycle protein OpcA from Corynebacterium efficiens (321 aa), fasta scores: E(): 9.9e-23, (34.826% identity in 201 aa overlap); and similar to several hypothetical proteins from Streptomyces coelicolor e.g. Q9XAB8|AL096839|SCC22.20 (351 aa), Fasta scores: E(): 7.1e-21, (36.0% identity in 203 aa overlap), although these have a short N-terminal extension relative to this homologue. Previously sequenced as Q49699|U00013 (265 aa), Fasta scores: E(): 0, (100.0% identity in 265 aa overlap). Q7AQI2 No intermediary metabolism and respiration PF10128 Q7AQI2 Rv1446c Rv1446c AL450380.2 Mycobrowser_v4 CDS 713859 714101 . + 0 ML0588 ML0588 Hypothetical protein ML0588, len: 80 aa. Hypothetical protein. Some similarity to several PPE family proteins e.g. P71657|Rv1387 PPE family protein from M. tuberculosis (539 aa), fasta scores: E(): 0.00072, (55.263% identity in 38 aa overlap). Previously sequenced as Q49686|U00013 (80 aa), Fasta scores: E(): 0, (98.8% identity in 80 aa overlap). Q7AQI0 No unknown Q7AQI0 AL450380.2 Mycobrowser_v4 CDS 707606 709705 . - 0 ML0583c tkt This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. It catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor [Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate] Probable transketolase Tkt (TK) ML0583c, len: 699 aa. Probable tkt, Transketolase (EC 2.2.1.1), highly similar to TKT_MYCTU|O06811|Rv1449c tkt, transketolase from M. tuberculosis (700 aa), Fasta scores: E(): 0, (89.1% identity in 700 aa overlap); and CAD96151|Mb1484c from M. bovis (700 aa). Similar to many e.g. TKT2_YEAST|P33315 tkl2, transketolase 2 from Saccharomyces cerevisiae (681 aa), Fasta scores: E(): 3.4e-99, (42.8% identity in 684 aa overlap). Previously sequenced as TKT_MYCLE|P46708 (699 aa), Fasta scores: E(): 0, (99.9% identity in 699 aa overlap). Contains Pfam match to entry PF00456 transketolase, Transketolase. Contains PS00801 Transketolase signature 1. Contains PS00802 Transketolase signature 2. Belongs to the Transketolase family. In M. tuberculosis tkt is thought to be differentially expressed within host cells (see Triccas et al., 1999). P46708 No intermediary metabolism and respiration PF00456,PF02779,PF02780 P46708 GO:0008152,GO:0004802,GO:0005509 2.2.1.1 Rv1449c Rv1449c AL450380.2 Mycobrowser_v4 CDS 725441 727010 . - 0 ML0599c fadE15 Probable acyl-CoA dehydrogenase FadE15 (pseudogene) ML0599c, len: 1570 bp. Possible pseudogene of M. tuberculosis orthologue fadE15|Rv1467c (1830 bp) (Best blastx scores: 267). Yes lipid metabolism Rv1467c Rv1467c AL450380.2 Mycobrowser_v4 CDS 727436 727598 . - 0 ML0599A ML0599A Probable transposase (pseudogene) ML0599A, len: 163 bp. Possible pseudogene similar to several M. tuberculosis transposases associated with IS6110 (Best blastx scores: 75) and identical to ML1291c, ML1242A, ML1820A, ML0568B from M. leprae. Yes unknown AL450380.2 Mycobrowser_v4 CDS 731676 732619 . - 0 ML0600c ML0600c Probable acyl-CoA dehydrogenase (pseudogene) ML0600c, len: 944 bp. Possible pseudogene similar to several acyl-CoA dehydrogenase in M. tuberculosis e.g. fadE26|Rv3504, fadE29|Rv3543c, fadE17|Rv1934c, fadE30|Rv3562 etc (Best blastx scores: 114) Yes unknown AL450380.2 Mycobrowser_v4 CDS 733141 733880 . + 0 ML0601 ML0601 Conserved hypothetical protein (pseudogene) ML0601, len: 740 bp. Possible pseudogene of M. tuberculosis orthologue Rv2415c (894 bp) (Best blastx scores: 191) Yes conserved hypotheticals Rv2415c Rv2415c AL450380.2 Mycobrowser_v4 CDS 809937 810484 . - 0 ML0673c ML0673c Possible oxidoreductase (pseudogene) ML0673c, len: 548 bp. Possible pseudogene of M. tuberculosis orthologue Rv3359 (1191 bp) (Best blastx scores: 307) Yes intermediary metabolism and respiration Rv3359 Rv3359 AL450380.2 Mycobrowser_v4 CDS 733928 734849 . + 0 ML0602 ML0602 Conserved hypothetical protein (pseudogene) ML0602, len: 922 bp. Possible pseudogene of M. tuberculosis orthologue Rv2414c (1545 bp) (Best blastx scores: 167). Yes conserved hypotheticals Rv2414c Rv2414c AL450380.2 Mycobrowser_v4 CDS 727883 728125 . - 0 ML0599B ML0599B Conserved hypothetical protein ML0599B, len: 80 aa. Conserved hypothetical protein, identical to the other hypothetical CDS ML0568A and ML1292c from M. leprae. No conserved hypotheticals AL450380.2 Mycobrowser_v4 CDS 729142 729540 . - 0 ML0599D ML0599D Hypothetical protein ML0599D, len: 132 aa. Hypothetical protein. No unknown AL450380.2 Mycobrowser_v4 CDS 729793 730215 . - 0 ML0599E ML0599E Hypothetical protein ML0599E, len: 140 aa. Hypothetical protein. No unknown AL450380.2 Mycobrowser_v4 CDS 724508 725005 . + 0 ML0597 ML0597 Possible nitrogen fixation related protein ML0597, len: 165 aa. Possible nitrogen fixation related protein, highly similar to O53156|AL123456|Rv1465 Possible nitrogen fixation related protein from M. tuberculosis (162 aa), Fasta scores: E(): 0, (79.4% identity in 165 aa overlap); and CAD96167|Mb1500 from M. bovis (162 aa). Also similar to O32163|NIFU_BACSU NifU-like protein from Bacillus subtilis (147 aa), fasta scores: E(): 9.5e-18, (41.481% identity in 135 aa overlap). Previously sequenced as Q49683|U00013 (165 aa), Fasta scores: E(): 0, (100.0% identity in 165 aa overlap). Contains Pfam match to entry PF01883 DUF59, Domain of unknown function. Contains Pfam match to entry PF01592 NifU_N, NifU-like N terminal domain. Q7AQH4 No intermediary metabolism and respiration PF01592 Q7AQH4 GO:0016226,GO:0051536,GO:0005515,GO:0005506 Rv1465 Rv1465 AL450380.2 Mycobrowser_v4 CDS 812528 813382 . + 0 ML0677 ML0677 Probable oxidoreductase (pseudogene) ML0677, len: 855 bp. Possible pseudogene similar to M. tuberculosis Rv0063 and also similar to Rv3351 and Rv3353 (Best blastx scores: 243). Yes unknown AL450380.2 Mycobrowser_v4 CDS 744739 746655 . - 0 ML0612c ML0612c Conserved hypothetical protein (pseudogene) ML0612c, len: 1917 bp. Possible pseudogene of M. tuberculosis orthologue Rv2402 (1929 bp) (Best blastx scores: 1589). Yes conserved hypotheticals Rv2402 Rv2402 AL450380.2 Mycobrowser_v4 CDS 746876 747775 . - 0 ML0613c ML0613c Probable oxidoreductase (pseudogene) ML0613c, len: 900 bp. Possible pseudogene similar to M. tuberculosis Rv1751 (1383 bp) (Best blastx scores: 134) Yes unknown AL450380.2 Mycobrowser_v4 CDS 749510 750256 . + 0 ML0616 cysT Probable sulphate transport integral membrane protein ABC transporter CysT (pseudogene) ML0616, len: 747 bp. Possible pseudogene of M. tuberculosis orthologue cysT|Rv2399c (852 bp) (Best blastx scores: 386). Yes cell wall and cell processes Rv2399c Rv2399c AL450380.2 Mycobrowser_v4 CDS 750259 750926 . + 0 ML0617 cysW Probable sulphate transport integral membrane protein ABC transporter CysW (pseudogene) ML0617, len: 668 bp. Possible pseudogene of M. tuberculosis orthologue cysW|Rv2398c (819 bp) (Best blastx scores: 281). Yes cell wall and cell processes Rv2398c Rv2398c AL450380.2 Mycobrowser_v4 CDS 736155 736415 . - 0 ML0604c rpsT Probable 30S ribosomal protein S20 RpsT ML0604c, len: 86 aa. Probable rpsT, 30s ribosomal protein s20, highly similar to RS20_MYCTU|P71731|Rv2412 rpsT, 30S ribosomal protein S20 from M. tuberculosis (86 aa), Fasta scores: E(): 8.8e-27, (87.2% identity in 86 aa overlap); and CAD97296|Mb2435 from M. bovis (86 aa). Similar to many e.g. RS20_ECOLI|P02378 rpsT, 30S ribosomal protein S20 from Escherichia coli (86 aa), Fasta scores: E(): 1.5e-08, (41.7% identity in 84 aa overlap). Previously sequenced as RS20_MYCLE|O33132 (86 aa), Fasta scores: E(): 2.1e-30, (98.8% identity in 86 aa overlap). Contains Pfam match to entry PF01649 Ribosomal_S20p, Ribosomal protein S20. Belongs to the S20P family of ribosomal proteins. O33132 No information pathways PF01649 O33132 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv2412 Rv2412 AL450380.2 Mycobrowser_v4 CDS 747778 748065 . + 0 ML0614 ML0614 Possible conserved membrane protein ML0614, len: 95 aa. Possible conserved membrane protein, similar but longer at the N terminus to Rv2401A possible conserved membrane protein from M. tuberculosis (67 aa), E(): 1.9e-15, (67.692% identity in 65 aa overlap); and CAD97285|Mb2424c possible conserved membrane protein from M. bovis (67 aa), fasta scores: E(): 4.9e-14, (66.154% identity in 65 aa overlap). Previously sequenced as Q49760|U00016 (95 aa), Fasta scores: E(): 0, (100.0% identity in 95 aa overlap). Q49760 No cell wall and cell processes Q49760 GO:0016021 Rv2401A Rv2401A AL450380.2 Mycobrowser_v4 CDS 767996 768474 . - 0 ML0636c ML0636c Possible lipoprotein (pseudogene) ML0636c, len: 479 bp. Possible pseudogene similar to M. tuberculosis lpqQ|Rv0835 (645 bp) (Best blastx scores: 118). Yes unknown AL450380.2 Mycobrowser_v4 CDS 768880 768987 . - 0 ML0636A ML0636A Possible glutaredoxin protein (pseudo) ML0636A, len: 108 bp. Possible pseudogene similar to M. tuberculosis Rv3198A (255 bp) (Best blastx scores: 132). Yes unknown AL450380.2 Mycobrowser_v4 CDS 792431 793543 . + 0 ML0655 ML0655 Possible conserved secreted protein (pseudogene) ML0655, len: 1113 bp. Possible pseudogene of M. tuberculosis orthologue Rv3163c (1272 bp) (Best blastx scores: 376) Yes cell wall and cell processes Rv3163c Rv3163c AL450380.2 Mycobrowser_v4 CDS 794102 794682 . - 0 ML0657c nuoN Probable NADH dehydrogenase I (chain N) NuoN (pseudogene) ML0657c, len: 581 bp. Possible pseudogene of M. tuberculosis orthologue nuoN|Rv3158 (1596 bp) (Best blastx scores: 137). Yes intermediary metabolism and respiration Rv3158 Rv3158 AL450380.2 Mycobrowser_v4 CDS 794995 795484 . - 0 ML0658c fadB4 Probable NADPH quinone oxidoreductase FadB4 (pseudogene) ML0658c, len: 490 bp. Possible pseudogene of M. tuberculosis orthologue fadB4|Rv3141 (972 bp) (Best blastx scores: 267) Yes lipid metabolism Rv3141 Rv3141 AL450380.2 Mycobrowser_v4 CDS 771427 771729 . + 0 ML0638 ML0638 Possible secreted protein ML0638, len: 100 aa. Possible secreted protein. Previously sequenced as Q49769|U00016 (100 aa), Fasta scores: E(): 0, (99.0% identity in 100 aa overlap). Contains a possible N-terminal signal sequence. Q49769 No cell wall and cell processes Q49769 GO:0005576 AL450380.2 Mycobrowser_v4 CDS 759042 759815 . + 0 ML0626 ML0626 Conserved hypothetical protein ML0626, len: 257 aa. Conserved hypothetical protein, highly similar to O05826|AL123456|Rv2372c conserved hypothetical protein from M. tuberculosis (262 aa), Fasta scores: E(): 0, (76.9% identity in 255 aa overlap); and CAD97254|Mb2393c from M. bovis (262 aa). Similar to many bacterial hypothetical proteins e.g. Q9S3Y4|AF170561 sdrD, hypothetical protein from Streptomyces coelicolor (216 aa), Fasta scores: E(): 1.2e-28, (44.8% identity in 223 aa overlap). Previously sequenced as Q49763|U00016 (128 aa), Fasta scores: E(): 0, (100.0% identity in 126 aa overlap). Belongs to the UPF0088 family. Q9CCN1 No conserved hypotheticals PF04452 Q9CCN1 GO:0006364,GO:0008168 Rv2372c Rv2372c AL450380.2 Mycobrowser_v4 CDS 773608 774444 . - 0 ML0641c ML0641c Conserved hypothetical protein (pseudogene) ML0641c, len: 837 bp. Possible pseudogene of M. tuberculosis orthologue Rv3196 (900 bp) (Best blastx scores: 289). Yes conserved hypotheticals Rv3196 Rv3196 AL450380.2 Mycobrowser_v4 CDS 782072 782520 . + 0 ML0645 ML0645 Hypothetical protein (pseudogene) ML0645, len: 449 bp. Possible pseudogene of M. tuberculosis orthologue Rv3172c (483 bp) (Best blastx scores: 176). Yes conserved hypotheticals Rv3172c Rv3172c AL450380.2 Mycobrowser_v4 CDS 783178 783858 . + 0 ML0646 hpx Possible non-heme haloperoxidase Hpx (pseudogene) ML0646, len: 681 bp. Possible pseudogene of M. tuberculosis orthologue hpx|Rv3171c (900 bp) (Best blastx scores: 187). Yes virulence, detoxification, adaptation Rv3171c Rv3171c AL450380.2 Mycobrowser_v4 CDS 786099 787166 . - 0 ML0648c ML0648c Conserved hypothetical protein (pseudogene) ML0648c, len: 1068 bp. Possible pseudogene of M. tuberculosis orthologue Rv3169 (1125 bp) (Best blastx scores: 168) Yes conserved hypotheticals Rv3169 Rv3169 AL450380.2 Mycobrowser_v4 CDS 787163 788297 . - 0 ML0649c ML0649c Conserved hypothetical protein (pseudogene) ML0649c, len: 1135 bp. Possible pseudogene of M. tuberculosis orthologue Rv3168 (1137 bp) (Best blastx scores: 320). Yes virulence, detoxification, adaptation Rv3168 Rv3168 AL450380.2 Mycobrowser_v4 CDS 788363 788663 . + 0 ML0650 ML0650 Probable transcriptional regulator Probably TetR-family) (pseudogene) ML0650, len: 301 bp. Possible pseudogene of M. tuberculosis orthologue Rv3167c (627 bp) (Best blastx scores: 210) Yes regulatory proteins Rv3167c Rv3167c AL450380.2 Mycobrowser_v4 CDS 788695 789823 . - 0 ML0651c ML0651c REP-family protein (pseudogene) ML0651c, len: 1129 bp. Possible pseudogene similar to M. tuberculosis REP-family proteins (Best blastx scores: 93) Yes unknown AL450380.2 Mycobrowser_v4 CDS 790109 791037 . + 0 ML0652 ML0652 Conserved hypothetical protein (pseudogene) ML0652, len: 929 bp. Possible pseudogene of M. tuberculosis orthologue Rv3166c (960 bp) (Best blastx scores: 276). Yes conserved hypotheticals Rv3166c Rv3166c AL450380.2 Mycobrowser_v4 CDS 791049 791529 . + 0 ML0653 ML0653 Hypothetical protein (pseudogene) ML0653, len: 481 bp. Possible pseudogene of M. tuberculosis orthologue Rv3165c (483 bp) (Best blastx scores: 151). Yes conserved hypotheticals Rv3165c Rv3165c AL450380.2 Mycobrowser_v4 CDS 811816 812292 . - 0 ML0676c ML0676c Conserved hypothetical protein ML0676c, len: 158 aa. Conserved hypothetical protein, highly similar to O50383|AL123456|Rv3354 conserved hypothetical protein from M. tuberculosis (129 aa), Fasta scores: E(): 6.2e-24, (55.9% identity in 127 aa overlap) and CAD95533|Mb3389 from M. bovis (129 aa). Also similar to O33192|AL123456|Rv1690, probable lipoprotein lprJ from M. tuberculosis (127 aa), Fasta scores: E(): 2e-09, (33.3% identity in 105 aa overlap). Previously sequenced as O32877|Z98271 (168 aa), Fasta scores: E(): 0, (100.0% identity in 158 aa overlap). Q9CCM4 No conserved hypotheticals PF05305 Q9CCM4 Rv3354 Rv3354 AL450380.2 Mycobrowser_v4 CDS 825392 826049 . - 0 ML0689c ML0689c Probable glucosamine-fructose-6-phosphate aminotransferase (pseudogene) ML0689c, len: 658 bp. Possible pseudogene similar to M. tuberculosis glmS (1875 bp), (Best blastx scores: 90), also similar to ML0371 a possible orthologue of M. tuberculosis glmS. Yes unknown AL450380.2 Mycobrowser_v4 CDS 826328 827764 . - 0 ML0690c sugI Probable sugar transport integral membrane protein SugI (pseudogene) ML0690c, len: 1437 bp. Possible pseudogene of M. tuberculosis orthologue sugI|Rv3331 (1509 bp) (Best blastx scores: 360). Also similar to ML2511 a possible pseudogene similar to M. tuberculosis sugI. Yes cell wall and cell processes Rv3331 Rv3331 AL450380.2 Mycobrowser_v4 CDS 830043 831173 . - 0 ML0692c ML0692c Probable aminotransferase (pseudogene) ML0692c, len: 1131 bp. Possible pseudogene of M. tuberculosis orthologue Rv3329 (1317 bp) (Best blastx scores: 840). Yes intermediary metabolism and respiration Rv3329 Rv3329 AL450380.2 Mycobrowser_v4 CDS 831184 831979 . + 0 ML0693 sigJ Probable alternative RNA polymerase sigma factor, ECF family SigJ (pseudogene) ML0693, len: 796 bp. Possible pseudogene of M. tuberculosis orthologue sigJ|Rv3328c (939 bp) (Best blastx scores: 342). Yes information pathways Rv3328c Rv3328c AL450380.2 Mycobrowser_v4 CDS 832027 832537 . - 0 ML0694c ML0694c Probable transposase fusion protein (pseudogene) ML0694c, len: 511 bp. Possible pseudogene of M. tuberculosis orthologue Rv3327 (1713 bp) (Best blastx scores: 175). Yes insertion seqs and phages Rv3327 Rv3327 AL450380.2 Mycobrowser_v4 CDS 833166 833502 . + 0 ML0695 ML0695 Possible oxidoreductase (pseudogene) ML0695, len: 337 bp. Possible pseudogene similar to M. tuberculosis Rv2893 (978 bp) (Best blastx scores: 106). Yes unknown AL450380.2 Mycobrowser_v4 CDS 897494 897754 . - 0 ML0755c ML0755c conserved hypothetical protein ML0755c, len: 86 aa. Conserved hypothetical protein, some similarity to Q9FCJ0 Hypothetical protein SCO5198 from Streptomyces coelicolor (171 aa), fasta scores: E(): 0.0049, (40.299% identity in 67 aa overlap) Q9CCK5 No conserved hypotheticals Q9CCK5 AL450380.2 Mycobrowser_v4 CDS 823170 824111 . + 0 ML0687 ML0687 Probable conserved integral membrane protein ML0687, len: 313 aa. Probable conserved integral membrane protein, highly similar to O53385|AL123456|Rv3335c conserved integral membrane protein from M. tuberculosis (289 aa), Fasta scores: E(): 0, (68.8% identity in 288 aa overlap); and from CAD95487| M. bovis (289 aa). Similar to several bacterial hypothetical proteins e.g. YHJD_ECOLI|P37642 yhjD, hypothetical protein from Escherichia coli (337 aa), Fasta scores: E(): 5e-30, (34.9% identity in 278 aa overlap); and Q8ZA35 Putative membrane protein from Yersinia pestis (360 aa), fasta scores: E(): 1.9e-31, (35.689% identity in 283 aa overlap). Previously sequenced as Q49909|U00022 (313 aa), Fasta scores: E(): 0, (100.0% identity in 313 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQG0 No cell wall and cell processes PF03631 Q7AQG0 GO:0004540 Rv3335c Rv3335c AL450380.2 Mycobrowser_v4 CDS 838835 839853 . + 0 ML0701 ML0701 Probable membrane protein (pseudogene) ML0701, len: 1019 bp. Possible pseudogene similar to M. tuberculosis Rv1481 (1008 bp) (Best blastx scores: 222), and similar to ML0702. Yes unknown AL450380.2 Mycobrowser_v4 CDS 839857 840814 . - 0 ML0702c ML0702c Probable membrane protein (pseudogene) ML0702c, len: 958 bp. Possible pseudogene similar to M. tuberculosis Rv1481 (1008 bp) (Best blastx scores: 92), and similar to ML0701. Yes unknown AL450380.2 Mycobrowser_v4 CDS 842233 843070 . - 0 ML0704c ML0704c Possible acid phosphatase (pseudogene) ML0704c, len: 838 bp. Possible pseudogene of M. tuberculosis orthologue Rv3310 (900 bp) (Best blastx scores: 491). Yes cell wall and cell processes Rv3310 Rv3310 AL450380.2 Mycobrowser_v4 CDS 843206 843832 . + 0 ML0705 upp Probable uracil phophoribosyltransferase Upp (pseudogene) ML0705, len: 627 bp. Possible pseudogene of M. tuberculosis orthologue upp|Rv3309c (624 bp) (Best blastx scores: 251). Yes intermediary metabolism and respiration Rv3309c Rv3309c AL450380.2 Mycobrowser_v4 CDS 848944 849543 . + 0 ML0710 ML0710 Conserved hypothetical protein (pseudogene) ML0710, len: 600 bp. Possible pseudogene similar to M. tuberculosis Rv2248 (816 bp) (Best blastx scores: 255). Yes unknown AL450380.2 Mycobrowser_v4 CDS 850437 851855 . + 0 ML0712 lpdA Probable dihydrolipoamide dehydrogenase LpdA (pseudogene) ML0712, len: 1419 bp. Possible pseudogene of M. tuberculosis orthologue lpdA|Rv3303c (1482 bp) (Best blastx scores: 410). Yes intermediary metabolism and respiration Rv3303c Rv3303c AL450380.2 Mycobrowser_v4 CDS 853694 854514 . + 0 ML0714 ML0714 Conserved hypothetical protein (pseudogene) ML0714, len: 821 bp. Possible pseudogene of M. tuberculosis orthologue Rv3300c (918 bp) (Best blastx scores: 559). Yes conserved hypotheticals Rv3300c Rv3300c AL450380.2 Mycobrowser_v4 CDS 856125 859814 . - 0 ML0716c lhr Probable ATP-dependent helicase Lhr (pseudogene) ML0716c, len: 3690 bp. Possible pseudogene of M. tuberculosis orthologue lhr|Rv3296 (4542 bp) (Best blastx scores: 824) Yes information pathways Rv3296 Rv3296 AL450380.2 Mycobrowser_v4 CDS 862130 863300 . - 0 ML0719c ML0719c Conserved hypothetical protein (pseudogene) ML0719c, len: 1171 bp. Possible pseudogene of M. tuberculosis orthologue Rv3292 (1248 bp) (Best blastx scores: 499). Yes conserved hypotheticals Rv3292 Rv3292 AL450380.2 Mycobrowser_v4 CDS 849829 850308 . - 0 ML0711c ML0711c Conserved hypothetical protein ML0711c, len: 159 aa. Conserved hypothetical protein, highly similar to O53356|AL123456|Rv3304 conserved hypothetical protein from M. tuberculosis (159 aa), Fasta scores: E(): 9.2e-64, (91.8% identity in 159 aa overlap); and CAD95424|Mb from M. bovis (159 aa). Similiar to Q82I17 Hypothetical protein from Streptomyces avermitilis (145 aa), fasta scores: opt: 612, E(): 2.3e-34, (59.184% identity in 147 aa overlap). Shows weak similarity to other hypothetical proteins e.g. Q44546|M23528 hypothetical protein from Azotobacter vinelandii (183 aa), Fasta scores: E(): 1.3e-06, (30.1% identity in 146 aa overlap). Previously sequenced as Q49927|U00022 (174 aa), Fasta scores: E(): 0, (98.7% identity in 149 aa overlap). Q9CCL6 No conserved hypotheticals PF06094 Q9CCL6 Rv3304 Rv3304 AL450380.2 Mycobrowser_v4 CDS 879535 880519 . - 0 ML0739c pstC1 Phosphate-transport integral membrane ABC transporter PstC1 (pseudogene) ML0739c, len: 985 bp. Possible pseudogene of M. tuberculosis orthologue pstC|Rv0935 (1017 bp) (Best blastx scores: 346). Yes cell wall and cell processes Rv0935 Rv0935 AL450380.2 Mycobrowser_v4 CDS 881784 882589 . - 0 ML0741c pstB Phosphate-transport ATP-binding protein ABC transporter PstB (pseudogene) ML0741c, len: 806 bp. Possible pseudogene of M. tuberculosis orthologue pstB|Rv0933 (831 bp) (Best blastx scores: 307) Yes cell wall and cell processes Rv0933 Rv0933 AL450380.2 Mycobrowser_v4 CDS 871120 871761 . - 0 ML0729c ML0729c Conserved hypothetical protein ML0729c, len: 213 aa. Conserved hypothetical protein, similar to P96887|AL123456|Rv3282 conserved hypothetical protein from M. tuberculosis (222 aa), Fasta scores: E(): 2.7e-57, (68.5% identity in 213 aa overlap); and CAD95402| from M. bovis (222 aa). Similar to maf-family proteins and other hypothetical proteins e.g. MAF_BACSU|Q02169 maf, protein involved in septum formation from Bacillus subtilis (189 aa), Fasta scores: E(): 4.8e-08, (29.1% identity in 196 aa overlap). Also similar to the N-terminal half of O95671|Y15521 asmtl, acetylserotonin methytransferase-like gene from Homo sapiens (629 aa), Fasta scores: E(): 2.1e-09, (31.6% identity in 193 aa overlap). Previously sequenced as Q49670|U00012 (213 aa), Fasta scores: E(): 0, (100.0% identity in 213 aa overlap). Q49670 No conserved hypotheticals PF02545 Q49670 GO:0005737 Rv3282 Rv3282 AL450380.2 Mycobrowser_v4 CDS 884242 885772 . + 0 ML0743 pknD Transmembrane serine-threonine protein kinase D PknD (pseudogene) ML0743, len: 1531 bp. Possible pseudogene of M. tuberculosis orthologue pknD|Rv0931c (1995 bp) (Best blastx scores: 458). Yes regulatory proteins Rv0931c Rv0931c AL450380.2 Mycobrowser_v4 CDS 885849 886982 . - 0 ML0744c ML0744c Conserved hypothetical protein (pseudogene) ML0744c, len: 1134 bp. Possible pseudogene of M. tuberculosis orthologue Rv3272 (1185 bp) (Best blastx scores: 782). Yes conserved hypotheticals Rv3272 Rv3272 AL450380.2 Mycobrowser_v4 CDS 887114 887967 . - 0 ML0745c ML0745c Conserved hypothetical protein (pseudogene) ML0745c, len: 854 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins e.g. Rv0731c, Rv3399, Rv3787 and Rv1729c (Best blastx scores: ). Yes unknown AL450380.2 Mycobrowser_v4 CDS 888119 888694 . + 0 ML0746 ML0746 Probable conserved integral membrane protein (pseudogene) ML0746, len: 576 bp. Possible pseudogene of M. tuberculosis orthologue Rv3271c (669 bp) (Best blastx scores: 151). Yes cell wall and cell processes Rv3271c Rv3271c AL450380.2 Mycobrowser_v4 CDS 891409 892025 . - 0 ML0749c ML0749c Conserved hypothetical protein (pseudogene) ML0749c, len: 617 bp. Possible pseudogene of M. tuberculosis orthologue Rv3268 (690 bp) (Best blastx scores: 385) Yes conserved hypotheticals Rv3268 Rv3268 AL450380.2 Mycobrowser_v4 CDS 896666 897427 . + 0 ML0754 ML0754 Conserved hypothetical protein (pseudogene) ML0754, len: 762 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical protein e.g. Rv3714, Rv3517, Rv1482, Rv1073 and Rv3555 (Best blastx scores: 231). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1094008 1094115 . - 0 ML0924A ML0924A Probable conserved membrane protein, ML0924A, len: 108 bp. Possible pseudogene similar to the N-terminus of Rv2219A from M. tuberculosis (Best blastx score: 71). Yes unknown AL450380.2 Mycobrowser_v4 CDS 911578 912771 . + 0 ML0768 alkB Probable transmembrane alkane 1-monooxygenase alkB (pseudogene) ML0768, len: 1194 bp. Possible pseudogene of M. tuberculosis orthologue Rv3252c|alkB (1251 bp) (Best blastx scores: 358). Yes lipid metabolism Rv3252c Rv3252c AL450380.2 Mycobrowser_v4 CDS 912780 912896 . + 0 ML0769 rubB Probable rubredoxin RubB (pseudogene) ML0769, len: 117 bp. Possible pseudogene of M. tuberculosis orthologue Rv3250c|rubB (183 bp) or Rv3251c|rubA (168 bp) (Best blastx scores: 105). Yes intermediary metabolism and respiration Rv3250c Rv3250c AL450380.2 Mycobrowser_v4 CDS 912999 913509 . + 0 ML0770 ML0770 Possible transcriptional regulatory protein (Probably TetR-family) (pseudogene) ML0770, len: 511 bp. Possible pseudogene of M. tuberculosis orthologue Rv3249c (636 bp) (Best blastx scores: 273) Yes regulatory proteins Rv3249c Rv3249c AL450380.2 Mycobrowser_v4 CDS 1017531 1018540 . + 0 ML0856 ML0856 Possible alanine rich oxidoreductase (pseudogene) ML0856, len: 1010 bp. Possible pseudogene of M. tuberculosis orthologue Rv2781c (1035 bp) (Best blastx scores: 337). Yes intermediary metabolism and respiration Rv2781c Rv2781c AL450380.2 Mycobrowser_v4 CDS 1422521 1422943 . + 0 ML1206 ML1206 Conserved hypothetical protein (pseudogene) ML1206, len: 423 bp. Possible pseudogene of M. tuberculosis orthologue Rv1546 (432 bp) (Best blastx scores: 213). Yes conserved hypotheticals Rv1546 Rv1546 AL450380.2 Mycobrowser_v4 CDS 1329965 1330426 . + 0 ML1138 ML1138 possible integral membrane protein ML1138, len: 153 aa. Possible integral membrane protein. Identical to the previously sequenced Mycobacterium leprae SW:YD03_MYCLE (P53431) (153 aa), Fasta scores: E(): 0, 99.3% identity in 153 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1303 SW:YD03_MYCTU (Q10619) (161 aa), Fasta scores: E(): 0, 69.8% identity in 149 aa overlap. Contains possible membrane spanning hydrophobic domains. P53431 No cell wall and cell processes PF05468 P53431 GO:0015078,GO:0016021,GO:0005886,GO:0045263,GO:0015986 Rv1303 Rv1303 AL450380.2 Mycobrowser_v4 CDS 906079 907176 . + 0 ML0764 ML0764 conserved hypothetical protein ML0764, len: 365 aa. Conserved hypothetical protein, highly similar to Rv3256c|O05899|Z95121 Conserved hypothetical protein from M. tuberculosis (346 aa), fasta scores: E(): 0, (75.3% identity in 365 aa overlap); and CAD95376|Mb3284c from M. bovis (346 aa). Also similar to other hypothetical bacterial proteins e.g. Q8FRJ8 Conserved hypothetical protein from Corynebacterium efficiens (329 aa), fasta scores: E(): 7.4e-11, (30.258% identity in 271 aa overlap). Q9CCJ6 No conserved hypotheticals Q9CCJ6 Rv3256c Rv3256c AL450380.2 Mycobrowser_v4 CDS 903228 903497 . + 0 ML0760 whiB2 Probable transcriptional regulatory protein WhiB-like WhiB2 ML0760, len: 89 aa. Probable whiB2 (alternate gene name: whmD), WhiB-like regulatory protein (see Hutter & Dick 1999), similar to Q53963|X62287 WhiB paralogue of Streptomyces coelicolor (85 aa), fasta scores: E(): 4.8e-26, (85.5% identity in 69 aa overlap). Highly similar to Rv3260c|MTV015.05c|O53353|AL021840 whiB2 regulatory protein from Mycobacterium tuberculosis (89 aa), fasta scores: E(): 0, (85.4% identity in 89 aa overlap); to Q9S426|AF164439 whmD regulatory protein (see Gomez & Bishai 2000) from Mycobacterium smegmatis (129 aa), fasta scores: E(): 1.6e-29, (84.1% identity in 82 aa overlap). Also similar to ML0382, ML0639, ML0804 and ML2307 from M. leprae. Q9CCK0 No regulatory proteins PF02467 Q9CCK0 Rv3260c Rv3260c AL450380.2 Mycobrowser_v4 CDS 924815 925330 . + 0 ML0780 ML0780 Probable conserved integral membrane protein (pseudogene) ML0780, len: 516 bp. Possible pseudogene of M. tuberculosis orthologue Rv3238c (735 bp) (Best blastx scores: 169). Yes cell wall and cell processes Rv3238c Rv3238c AL450380.2 Mycobrowser_v4 CDS 927402 927983 . - 0 ML0783c ML0783c Hypothetical alanine, arginine and proline rich protein (pseudogene) ML0783c, len: 582 bp. Possible pseudogene of M. tuberculosis orthologue Rv3235 (642 bp) (Best blastx scores: 155). Yes conserved hypotheticals Rv3235 Rv3235 AL450380.2 Mycobrowser_v4 CDS 928182 928875 . + 0 ML0784 ML0784 Conserved hypothetical protein (pseudogene) ML0784, len: 694 bp. Possible pseudogene of M. tuberculosis orthologue Rv3234c (816 bp) (Best blastx scores: 286). Yes lipid metabolism Rv3234c Rv3234c AL450380.2 Mycobrowser_v4 CDS 928968 929497 . + 0 ML0785 ML0785 Conserved hypothetical protein (pseudogene) ML0785, len: 530 bp. Possible pseudogene of M. tuberculosis orthologue Rv3233c (591 bp) (Best blastx scores: 202). Yes lipid metabolism Rv3233c Rv3233c AL450380.2 Mycobrowser_v4 CDS 929728 930224 . + 0 ML0786 pvdS Possible alternative RNA polymerase sigma factor PvdS (pseudogene) ML0786, len: 497 bp. Possible pseudogene of M. tuberculosis orthologue Rv3232c|pvdS (888 bp) (Best blastx scores: 85). Yes intermediary metabolism and respiration Rv3232c Rv3232c AL450380.2 Mycobrowser_v4 CDS 930317 930631 . + 0 ML0787 ML0787 Conserved hypothetical protein (pseudogene) ML0787, len: 315 bp. Possible pseudogene of M. tuberculosis orthologue Rv3231c (510 bp) (Best blastx scores: 184) Yes conserved hypotheticals Rv3231c Rv3231c AL450380.2 Mycobrowser_v4 CDS 930895 931943 . + 0 ML0788 ML0788 Putative oxidoreductase (pseudogene) ML0788, len: 1049 bp. Possible pseudogene of M. tuberculosis orthologue Rv3230c (1143 bp) (Best blastx scores: 278). Yes intermediary metabolism and respiration Rv3230c Rv3230c AL450380.2 Mycobrowser_v4 CDS 933511 934327 . - 0 ML0790c ML0790c Probable beta-ketoacyl-CoA thiolase (pseudogene) ML0790c, len: 817 bp. Possible pseudogene similar to M. tuberculosis fadA3|Rv1074c (1218 bp) (Best blastx scores: 143) and to fadA6 and fadA5. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1031320 1032062 . - 0 ML0867c cobS Probable cobalamin (5'-phosphate) synthase CobS (pseudogene) ML0867c, len: 743 bp. Possible pseudogene of M. tuberculosis orthologue cobS|Rv2208 (750 bp) (Best blastx scores: 348). Yes intermediary metabolism and respiration Rv2208 Rv2208 AL450380.2 Mycobrowser_v4 CDS 1918059 1918506 . - 0 ML1593c ML1593c Immunogenic protein (pseudogene) ML1593c, len: 448 bp. Possible pseudogene similar to M. tuberculosis Rv1926c|mpt63 (480 bp) (Best blastx scores: 67). Yes unknown AL450380.2 Mycobrowser_v4 CDS 920656 920850 . + 0 ML0777 ML0777 hypothetical protein ML0777, len: 64 aa. Hypothetical protein. Q9CCI8 No unknown Q9CCI8 AL450380.2 Mycobrowser_v4 CDS 920259 920516 . + 0 ML0776 ML0776 conserved hypothetical protein ML0776, len: 85 aa. Conserved hypothetical protein, highly similar to the N-terminal half of Rv3242c|MTCY20B11.17c|O05887 Conserved hypothetical protein from Mycobacterium tuberculosis (213 aa), fasta scores: E(): 6.8e-18, (78.1% identity in 64 aa); and CAD95362| from M. bovis (213 aa). Q9CCI9 No conserved hypotheticals Q9CCI9 Rv3242c Rv3242c AL450380.2 Mycobrowser_v4 CDS 920954 921643 . + 0 ML0778 ML0778 conserved hypothetical protein ML0778, len: 229 aa. Conserved hypothetical protein, similar to many hypothetical proteins and to some putative ribosomal proteins e.g. Rv3241c|MTCY20B11.16c|O05886|Z95121 Conserved hypothetical protein from Mycobacterium tuberculosis (213 aa), fasta scores: E(): 4.4e-79, (89.3% identity in 206 aa); and RR30_SPIOL|P19954 30s ribosomal protein S30, chloroplast precursor RPS30 from Spinacia oleracea (302 aa), fasta scores: E(): 1.3e-10, (26.8% identity in 213 aa). Q9CCI7 No information pathways PF02482 Q9CCI7 GO:0044238,GO:0005488 Rv3241c Rv3241c AL450380.2 Mycobrowser_v4 CDS 937637 938914 . - 0 ML0794c ML0794c REP-family protein (pseudogene) ML0794c, len: 1278 bp. Possible pseudogene similar to M. tuberculosis REP-family proteins (Best blastx scores: 135) Yes unknown AL450380.2 Mycobrowser_v4 CDS 939223 941361 . - 0 ML0795c atsD Possible arylsulfatase AtsD (pseudogene) ML0795c, len: 2139 bp. Possible pseudogene of M. tuberculosis orthologue atsD|Rv0663 (2367 bp) (Best blastx scores: 485). Yes intermediary metabolism and respiration Rv0663 Rv0663 AL450380.2 Mycobrowser_v4 CDS 934529 935512 . - 0 ML0791c ML0791c conserved hypothetical protein ML0791c, len: 327 aa. Conserved hypothetical protein, highly similar to Rv3228|MTCY20B11.03|O05873|Z95121 Conserved hypothetical protein from M.tuberculosis (330 aa), fasta scores: E(): 0, (84.0% identity in 331 aa); and CAD95349| from M. bovis (330 aa). Also similar to several hypothetical bacterial proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces coelicolor (337 aa), FASTA scores: E(): 3.7e-43 (54.819% identity in 332 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CCI4 No conserved hypotheticals PF03193 Q9CCI4 GO:0003924,GO:0008270,GO:0005525 Rv3228 Rv3228 AL450380.2 Mycobrowser_v4 CDS 881072 881655 . - 0 ML0740c pstS1 Periplasmic phosphate-binding lipoprotein PstS1 (pseudogene) ML0740c, len: 584 bp. Possible pseudogene of M. tuberculosis orthologue pstS1|Rv0934 (1125 bp) (Best blastx scores: 238). Yes cell wall and cell processes Rv0934 Rv0934 AL450380.2 Mycobrowser_v4 CDS 1430415 1431246 . + 0 ML1210 ML1210 Putative transcriptional regulatory protein (pseudogene) ML1210, len: 832 bp. Possible pseudogene similar to several transcriptional regulators e.g. Q827C4 Putative GntR-family transcriptional regulator from Streptomyces avermitilis (Best blastx scores: 195). Q9CC69 Yes unknown Q9CC69 AL450380.2 Mycobrowser_v4 CDS 753533 754036 . + 0 ML0620 cfp2 Low molecular weight antigen, secreted protein ML0620, len: 167 aa. cfp2 (alternate gene name: mtb12), low molecular weight antigen, secreted protein, similar to MB12_MYCTU|O05822|Rv2376c cfp2, low molecular weight antigen from M. tuberculosis (168 aa), Fasta scores: E(): 0, (65.5% identity in 165 aa overlap); and CAD97258|Mb2397c from M. bovis (168 aa). Previously sequenced as MB12_MYCLE|Q49771 (165 aa), Fasta scores: E(): 0, (100.0% identity in 165 aa overlap). Belongs to the mtb12 family. Q49771 No cell wall and cell processes Q49771 GO:0005576 Rv2376c Rv2376c AL450380.2 Mycobrowser_v4 CDS 760115 761164 . + 0 ML0627 phoH1 Probable phoH-like protein PhoH1 (Phosphate starvation-inducible protein PsiH) ML0627, len: 329 aa. Probable phoH1, phoH-like protein (phosphate starvation-induced protein), probably ATP-binding protein, highly similar to PHOL_MYCTU|O05830|Rv2368c phoH, phoH-family protein from M. tuberculosis (352 aa), Fasta scores: E(): 1.4e-116, (88.9% identity in 352 aa overlap); and CAD97250|Mb2389c from M. bovis (352 aa). Similar to others e.g. PHOH_ECOLI|P31544 phoH, phosphate starvation-inducible protein from Escherichia coli (354 aa), Fasta scores: E(): 1.2e-29, (36.8% identity in 304 aa overlap). Some similarity to ML1951 from M. leprae. Previously sequenced as PHOL_MYCLE|Q49751 (349 aa), Fasta scores: E(): 0, (99.7% identity in 349 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the PhoH family. Note that previously known as phoH. Q49751 No intermediary metabolism and respiration PF00013,PF02562 Q49751 GO:0003723,GO:0005737,GO:0005524 Rv2368c Rv2368c AL450380.2 Mycobrowser_v4 CDS 872009 873658 . - 0 ML0731c accD5 Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) ML0731c, len: 549 aa. Probable accD5, propyonyl-CoA carboxylase beta chain 5 (EC 6.4.1.3), highly similar to Rv3280|MTCY71.20|P96885|Z92771 accD5, propyonyl-CoA carboxylase beta chain 5 from Mycobacterium tuberculosis (548 aa), fasta scores: E(): 0, (88.7% identity in 549 aa); and CAD95400|Mb3308 from M. bovis (548 aa). Also highly similar to others e.g. PCCB_SACER|P53003 pccB propionyl-CoA carboxylase beta chain from Saccharopolyspora erythraea (546 aa), fasta scores: E(): 3.2e-158, (69.1% identity in 530 aa); and O87201|DTSR2 DTSR2 PROTEIN INVOLVED IN GLUTAMATE PRODUCTION from Corynebacterium glutamicum (Brevibacterium flavum) (537 aa), FASTA scores: opt: 2604, E(): 5.9e-168, (72.71% identity in 537 aa overlap) (see Kimura et al., 1996). Also similar to ML0102 and ML1657 from M. leprae. Previously sequenced as PCCB_MYCLE|P53002. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. BELONGS TO THE ACCD/PCCB FAMILY. P53002 No lipid metabolism PF01039 P53002 GO:0004658,GO:0005524 6.4.1.3 Rv3280 Rv3280 AL450380.2 Mycobrowser_v4 CDS 935509 936801 . - 0 ML0792c aroA INVOLVED IN THE BIOSYNTHESIS OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO ACIDS (THE SHIKIMATE PATHWAY). ACTS IN THE SIXTH STEP OF THIS PATHWAY. [CATALYTIC ACTIVITY: PHOSPHOENOLPYRUVATE + 3-PHOSPHOSHIKIMATE = ORTHOPHOSPHATE + O(5)-(1-CARBOXYVINYL)-3-PHOSPHOSHIKIMATE]. probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS) ML0792c, len: 430 aa. Probable aroA, 3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19) (see citation below), highly similar to Rv3227|MTCY20B11.02|AROA_MYCTU|P22487 aroA, 3-phosphoshikimate 1-carboxyvinyl transferase from Mycobacterium tuberculosis (450 aa), fasta scores: E(): 2e-132, (79.0% identity in 428 aa); and CAD95348|Mb3256 from M. bovis (450 aa). Similar to several e.g. Q9K4A7|ARA2_STRCO 3-phosphoshikimate 1-carboxyvinyl transferase from Streptomyces coelicolor (438 aa), fasta scores: E(): 1.2e-69, (53.009% identity in 432 aa overlap). Contains Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). Contains PS00885 EPSP synthase signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY. Q9CCI3 No intermediary metabolism and respiration PF00275 Q9CCI3 GO:0009073,GO:0005737,GO:0003866 2.5.1.19 Rv3227 Rv3227 AL450380.2 Mycobrowser_v4 CDS 523804 524289 . - 0 ML0424c bcp Probable bacterioferritin comigratory protein Bcp ML0424c, len: 161 aa. Probable bcp, bacterioferritin comigratory protein, highly similar to Rv2521|O5322|AL123456 bcp, bacterioferritin comigratory protein from M. tuberculosis (157 aa), Fasta scores: E(): 0, (79.6% identity in 157 aa overlap). Similar to many members of the AhpC/TSA family, suggesting a protective, antioxidant role. e.g. shows similarity to BAA90524|AB037598 prxQ, peroxiredoxin Q from Sedum lineare (186 aa), Fasta scores: E(): 3e-17, (40.0% identity in 155 aa overlap); P23480|BCP_ECOLI|B2480|BAB36765|Z3739|ECS3342 BACTERIOFERRITIN COMIGRATORY PROTEIN from Escherichia coli strain K12 (156 aa). Previously sequenced as O07705|Z97179 (161 aa), Fasta scores: E(): 0, (99.4% identity in 161 aa overlap). Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family. O07705 No virulence, detoxification, adaptation PF00578 O07705 GO:0045454,GO:0016491,GO:0016209 Rv2521 Rv2521 AL450380.2 Mycobrowser_v4 CDS 483452 485161 . + 0 ML0389 choD Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) ML0389, len: 569 aa. Probable choD, cholesterol oxidase precursor (EC 1.1.3.6), highly similar to Rv3409c|Q57307|Al123456 choD, putative cholesterol oxidase from M. tuberculosis (578 aa), Fasta scores: E(): 0, (88.6% identity in 569 aa overlap). Also similar to CHOD_STRSQ|P12676 choA, cholesterol oxidase precursor from Streptomyces sp. (strain SA-COO) (546 aa), Fasta scores: E(): 0.013, (26.6% identity in 561 aa overlap); and similar to other oxidoreductases e.g. Q9A7T6|CC1634 OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus (579 aa). Previously sequenced as Q59530|U00015 (585 aa), Fasta scores: E(): 0, (100.0% identity in 569 aa overlap). Q9CCV1 No lipid metabolism PF01266 Q9CCV1 GO:0016491 Rv3409c Rv3409c AL450380.2 Mycobrowser_v4 CDS 1170356 1170599 . + 0 ML1000 ML1000 Putative ESAT-6 like protein (pseudogene) ML1000, len: 244 bp. Possible pseudogene similar to several M. tuberculosis putative ESAT-6 like proteins e.g. Rv2346, Rv1198, Rv3619 and Rv1037 etc (Best blastx scores: 132). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1506795 1507575 . + 0 ML1262 impA Probable inositol monophosphtase ImpA (pseudogene) ML1262, len: 781 bp. Possible pseudogene of M. tuberculosis orthologue impA|Rv1604 (813 bp) (Best blastx scores: 633). Yes intermediary metabolism and respiration Rv1604 Rv1604 AL450380.2 Mycobrowser_v4 CDS 845461 846267 . - 0 ML0707c deoD Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) ML0707c, len: 268 aa. Probable deoD, purine nucleoside phosphorylase (EC 2.4.2.1), highly similar to PUNA_MYCTU|O53359|Rv3307 probable deoD purine nucleoside phosphorylase from M. tuberculosis (268 aa), Fasta scores: E(): 5.8e-81, (82.1% identity in 262 aa overlap). Similar to many others e.g. PUNA_BACST|P77834 deoD, purine nucleoside phosphorylase I from Bacillus stearothermophilus (274 aa), Fasta scores: E(): 6.5e-16, (43.1% identity in 246 aa overlap). Previously sequenced as PUNA_MYCLE|P46862 (268 aa), Fasta scores: E(): 0, (99.6% identity in 268 aa overlap). Contains Pfam match to entry PF00896 Mtap_PNP, phosphorylases family 2. Contains PS01240 Purine and other phosphorylases family 2 signature. BELONGS TO THE PNP/MTAP FAMILY 2 OF PHOSPHORYLASES. P46862 No intermediary metabolism and respiration PF01048 P46862 GO:0004731,GO:0009116 2.4.2.1 Rv3307 Rv3307 AL450380.2 Mycobrowser_v4 CDS 1498154 1498540 . - 0 ML1253c glbO POSSIBLE GLOBIN (OXYGEN-BINDING PROTEIN) GLBO ML1253c, len: 128 aa. Possible glbO, globin-like protein. Highly similar to putative globins from Mycobacterium tuberculosis Rv2470 TR:O53197 (EMBL:AL021246) (128 aa), Fasta scores: E(): 0, 88.7% identity in 124 aa overlap and Mycobacterium bovis TR:AAF36597 (EMBL:AF213450) (128 aa), Fasta scores: E(): 0, 88.7% identity in 124 aa overlap. Q9CC59 No intermediary metabolism and respiration PF01152 Q9CC59 GO:0019825,GO:0015671,GO:0005344,GO:0020037 Rv2470 Rv2470 AL450380.2 Mycobrowser_v4 CDS 1367137 1367393 . + 0 ML1169 ML1169 9.5 kDa culture filtrate antigen Cfp10A (pseudogene) ML1169, len: 257 bp. Possible pseudogene of M. tuberculosis orthologue Rv1335 (282 bp) (Best blastx scores: 114). Yes intermediary metabolism and respiration Rv1335 Rv1335 AL450380.2 Mycobrowser_v4 CDS 1527795 1528795 . - 0 ML1283c cydB Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB (pseudogene) ML1283c, len: 1001 bp. Possible pseudogene of M. tuberculosis orthologue cydB|Rv1622c (1041 bp) (Best blastx scores: 722). Yes intermediary metabolism and respiration Rv1622c Rv1622c AL450380.2 Mycobrowser_v4 CDS 588044 589384 . - 0 ML0485c gabT Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEMIALDEHYDE TRANSAMINASE) (GABA AMINOTRANSFERASE) (GABA-AT) ML0485c, len: 446 aa. Probable gabT, 4-aminobutyrate aminotransferase (EC 2.6.1.9), highly similar to GABT_MYCTU|Q50632|Rv2589 gabT, 4-aminobutyrate aminotransferase from M. tuberculosis (449 aa), Fasta scores: E(): 9.5e-157, (83.7% identity in 449 aa overlap); and CAD94805 4-aminobutyrate aminotransferase from M. bovis (449 aa), fasta scores: E(): 9.5e-157, (83.742% identity in 449 aa overlap). Similar to many e.g. O86823|GABT from Streptomyces coelicolor (444 aa), FASTA scores: E(): 8.9e-111, (61.765% identity in 442 aa overlap); GABT_ECOLI|P22256 gabT, 4-aminobutyrate aminotransferase from Escherichia coli (426 aa), Fasta scores: E(): 0, (43.1% identity in 422 aa overlap). Also similar to ML1216, ML1409 and ML2414. Previously sequenced as GABT_MYCLE|P40829 (446 aa), Fasta scores: E(): 0, (99.8% identity in 446 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate. P40829 No intermediary metabolism and respiration PF00202 P40829 GO:0003867,GO:0009448,GO:0030170,GO:0047298 2.6.1.22,2.6.1.19 Rv2589 Rv2589 AL450380.2 Mycobrowser_v4 CDS 508756 509982 . + 0 ML0411 ML0411 serine-rich antigen ML0411, len: 408 aa. Member of the Mycobacteria PPE family. Similar to numerous M. tuberculosis PPE-family proteins e.g. Rv2108|P95315|AL123456 PPE-family protein (243 aa), Fasta scores: E(): 5.8e-17, (34.4% identity in 212 aa overlap). M. leprae serine-rich antigen (25L) (45 kDa protein). Also similar to ML0539, ML1182 and ML1991 from M. leprae. Previously sequenced as SRA_MYCLE|Q07297 (408 aa), Fasta scores: E(): 0, (100.0% identity in 408 aa overlap). Contains Pfam match to entry PF00823 PPE, PPE family. Q07297 No PE/PPE PF00823 Q07297 AL450380.2 Mycobrowser_v4 CDS 529521 530885 . + 0 ML0430 ML0430 Probable conserved integral membrane leucine and alanine rich protein ML0430, len: 454 aa. Probable conserved integral membrane leu-, ala-rich protein, highly similar to Rv2508c|O06171|AL123456 conserved integral membrane from M. tuberculosis (445 aa), Fasta scores: E(): 0, (75.7% identity in 441 aa overlap). Also similar to hypothetical or membrane proteins e.g. Q9RKX9|AL133213|SC6D7.19C putative integral membrane protein from Streptomyces coelicolor (486 aa), Fasta scores: E(): 1.5e-13, (29.7% identity in 445 aa overlap). Previously sequenced as O07710|Z97179 (464 aa), Fasta scores: E(): 0, (100.0% identity in 454 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CCU4 No cell wall and cell processes PF07690 Q9CCU4 Rv2508c Rv2508c AL450380.2 Mycobrowser_v4 CDS 1716108 1716700 . - 0 ML1429c ML1429c Probable alternative RNA polymerase sigma factor (pseudogene) ML1429c, len: 593 bp. Possible pseudogene similar to several M. tuberculosis sigma factors e.g. sig I|Rv1189, sig J|Rv3328c, sigE|Rv1221 and sigG|Rv0182c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 680811 681707 . + 0 ML0563 ML0563 Conserved hypothetical protein ML0563, len: 298 aa. Conserved hypothetical protein, highly similar to YE21_MYCTU|P71690|Rv1421 conserved hypothetical protein from M. tuberculosis (301 aa), Fasta scores: E(): 0, (92.3% identity in 285 aa overlap); and CAD94317|Mb1456 from M. bovis (301 aa). Conserved in other bacteria e.g. Q9Z513|YJ52_STRCO Hypothetical UPF0042 protein from Streptomyces coelicolor (299 aa), fasta scores: E(): 2.2e-62, (54.698% identity in 298 aa overlap). Contains a match to Pfam entry PF03668; ATP_bind2;1. Q9CCP0 No conserved hypotheticals PF03668 Q9CCP0 GO:0005524 Rv1421 Rv1421 AL450380.2 Mycobrowser_v4 CDS 1235877 1236695 . - 0 ML1072c ML1072c Probable tetronasin-transport integral membrane ABC transporter (pseudogene) ML1072c, len: 819 bp. Possible pseudogene of M. tuberculosis orthologue Rv1217c (1647 bp) (Best blastx scores: 362). Yes cell wall and cell processes Rv1217c Rv1217c AL450380.2 Mycobrowser_v4 CDS 735003 736118 . + 0 ML0603 ML0603 Probable lipoprotein ML0603, len: 371 aa. Probable lipoprotein, highly similar but longer at the N-terminus to P71730|AL123456|Rv2413c conserved hypothetical protein from M. tuberculosis (316 aa), Fasta scores: E(): 0, (83.5% identity in 316 aa overlap); and CAD97297|Mb2436c from M. bovis (316 aa). Also similar to Q9RDM2|AL136518|SCC123.02C putative DNA-binding protein from Streptomyces coelicolor (336 aa), Fasta scores: E(): 0, (39.3% identity in 326 aa overlap). Previously sequenced as Q49756|U00016 (389 aa), Fasta scores: E(): 0, (100.0% identity in 371 aa overlap). Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7AQH2 No cell wall and cell processes, conserved hypotheticals PF06144 Q7AQH2 GO:0009360,GO:0006260,GO:0003887,GO:0003677 Rv2413c Rv2413c AL450380.2 Mycobrowser_v4 CDS 772069 773490 . - 0 ML0640c ML0640c Probable conserved ATP-binding protein ABC transporter ML0640c, len: 473 aa. Probable conserved ATP-binding protein ABC transporter, highly similar to O53343|AL123456|Rv3197 conserved ATP-binding protein ABC transporter from M. tuberculosis (447 aa), Fasta scores: E(): 0, (83.0% identity in 447 aa overlap); and CAD95312|Mb3220 from M. bovis (447 aa). Similar to other proteins (generally ABC transporters) e.g. Q9FCJ6 Hypothetical protein SCO5192 from Streptomyces coelicolor (469 aa), fasta scores: opt: 1252, E(): 3.3e-72, (46.222% identity in 450 aa overlap). Also similar to ML1898. Previously sequenced as Q49747|U00016 (267 aa), Fasta scores: E(): 0, (99.6% identity in 248 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q9CCM8 No cell wall and cell processes PF03109 Q9CCM8 Rv3197 Rv3197 AL450380.2 Mycobrowser_v4 CDS 955684 955999 . - 0 ML0807c ML0807c Possible acyltransferase (pseudogene) ML0807c, len: 316 bp. Possible pseudogene of M. tuberculosis orthologue Rv3216 (333 bp) (Best blastx scores: 171). Yes intermediary metabolism and respiration Rv3216 Rv3216 AL450380.2 Mycobrowser_v4 CDS 1717311 1718070 . - 0 ML1431c ML1431c Conserved hypothetical protein (pseudogene) ML1431c, len: 760 bp. Possible pseudogene of M. tuberculosis orthologue Rv2042c (798 bp) (Best blastx scores: 314). Yes conserved hypotheticals Rv2042c Rv2042c AL450380.2 Mycobrowser_v4 CDS 1281254 1282169 . - 0 ML1108c ML1108c Probable aminotransferase (pseudogene) ML1108c, len: 916 bp. Possible pseudogene of M. tuberculosis orthologue Rv0075 (1173 bp) (Best blastx scores: 290). Yes intermediary metabolism and respiration Rv0075 Rv0075 AL450380.2 Mycobrowser_v4 CDS 915870 916556 . + 0 ML0773 mtrA probable two-component sensory transduction transcriptional regulatory protein MtrA ML0773, len: 228 aa. Probable mtrA, transcriptional activator, response regulator (see citations below), highly similar to Rv3246c|MTCY20B11.21c|Q50447|Z95121 mtrA, transcriptional activator from Mycobacterium tuberculosis (228 aa), fasta scores: E(): 1.3e-92, (98.7% identity in 228 aa); and CAD93364|Mb3274c from M. bovis (227 aa). Also highly similar to others e.g. AFQ1_STRCO|Q04942 transcriptional regulatory protein afsQ1 from Streptomyces coelicolor (225 aa), fasta scores: E(): 1.7e-40, (47.1% identity in 221 aa). Also similar to ML0174, ML1286, ML2123 and ML2439 from M. leprae. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments in M. tuberculosis have showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages. Q9CCJ2 No regulatory proteins PF00072,PF00486 Q9CCJ2 GO:0006355,GO:0006350,GO:0000156,GO:0000160,GO:0003677 Rv3246c Rv3246c AL450380.2 Mycobrowser_v4 CDS 943530 944970 . - 0 ML0797c PPE PPE-family protein (pseudogene) ML0797c, len: 1440 bp. Possible pseudogene similar to several M. tuberculosis PPE-family proteins e.g. PPE23, PPE32, PPE14 PPE26 etc (Best blastx scores: 193). Yes unknown AL450380.2 Mycobrowser_v4 CDS 958212 958644 . + 0 ML0809 ML0809 Possible soj/parA-related protein (pseudogene) ML0809, len: 432 bp. Possible pseudogene of M. tuberculosis orthologue Rv3213c (801 bp) (Best blastx scores: 239). Yes cell wall and cell processes Rv3213c Rv3213c AL450380.2 Mycobrowser_v4 CDS 1026904 1027218 . + 0 ML0863 ML0863 hypothetical protein ML0863, len: 104 aa. Hypothetical unknown protein. Previously sequenced as O32957|Z98741. Q7AQE5 No unknown Q7AQE5 AL450380.2 Mycobrowser_v4 CDS 598030 598917 . - 0 ML0492c ppiB Probable peptidyl-prolyl cis-trans isomerase B PpiB (Cyclopphilin) (Ppiase) (Rotamase) (Peptidylprolyl isomerase) ML0492c, len: 295 aa. Probable ppiB, cyclophilin (peptidyl-prolyl cis-trans isomerase) (EC 5.2.1.8), highly similar to CYPB_MYCTU|Q50639|Rv2582 ppiB, probable peptidyl-prolyl cis-trans isomerase from M. tuberculosis (308 aa), Fasta scores: E(): 1.3e-79, (72.5% identity in 295 aa overlap); and CAD94798|Mb2613 from M. bovis (308 aa). Also similar to others e.g. Q9KJG8|PPIB PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces lividans (277 aa), FASTA scores: E(): 4.1e-24, (40.268% identity in 298 aa overlap). Previously sequenced as CYPB_MYCLE|P46697 (295 aa), Fasta scores: E(): 0, (99.7% identity in 295 aa overlap). Contains hydrophobic, possible membrane-spanning region. Alternatively, this may represent an N-terminal signal sequence, given the potential start codon at codon 33. Contains Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase. Belongs to the cyclophilin-type Ppiase family. P46697 No information pathways PF00160 P46697 GO:0006457,GO:0003755 5.2.1.8 Rv2582 Rv2582 AL450380.2 Mycobrowser_v4 CDS 664261 666216 . + 0 ML0548 priA RECOGNIZES A SPECIFIC HAIRPIN SEQUENCE ON PHIX SSDNA; THIS STRUCTURE IS THEN RECOGNIZED AND BOUND BY PROTEINS PRIB AND PRIC. FORMATION OF THE PRIMOSOME PROCEEDS WITH THE SUBSEQUENT ACTIONS OF DNAB, DNAC, DNAT AND PRIMASE. PRIA THEN FUNCTIONS AS A HELICASE WITHIN THE PRIMOSOME Putative primosomal protein N' PriA (Replication factor Y). ML0548, len: 651 aa. Putative priA, primosomal protein N', highly similar to PRIA_MYCTU|P71670|Rv1402 priA, putative primosomal protein N' from M. tuberculosis (655 aa), Fasta scores: E(): 0, (80.7% identity in 658 aa overlap); and CAD94298|Mb1437 from M. bovis (655 aa). Similar to many e.g. PRIA_ECOLI|P17888 priA, primosomal protein N' from Escherichia coli (732 aa), Fasta scores: E(): 1.2e-16, (28.1% identity in 445 aa overlap). COMPARED TO OTHER BACTERIAL PRIA, IT HAS A VERY DIVERGENT HELICASE DOMAIN. Belongs to the helicase family. PriA subfamily. Q9CCQ3 No information pathways Q9CCQ3 GO:0003677,GO:0006269,GO:0005658,GO:0004386,GO:0008270,GO:0005524 3.6.1.- Rv1402 Rv1402 AL450380.2 Mycobrowser_v4 CDS 1740102 1740488 . - 0 ML1446c ML1446c conserved hypothetical protein ML1446c, len: 128 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2061c TR:O86340 (EMBL:Z97984) (134 aa), Fasta scores: E(): 0, 70.2% identity in 131 aa overlap. Q9CC02 No conserved hypotheticals PF01243 Q9CC02 GO:0010181 Rv2061c Rv2061c AL450380.2 Mycobrowser_v4 CDS 1384842 1385330 . - 0 ML1185c ML1185c Probable cytochrome p450 (pseudogene) ML1185c, len: 489 bp. Possible pseudogene similar to several M. tuberculosis cytochrome p450 e.g. cyp126|Rv0778, cyp144|Rv1777, cyp140|Rv1880c etc (Best blastx scores: 111). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1414049 1414555 . - 0 ML1196c ML1196c Conserved hypothetical protein (pseudogene) ML1196c, len: 507 bp. Possible pseudogene similar to M. tuberculosis Rv3832c (576 bp) (Best blastx scores: 159). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1474994 1475164 . - 0 ML1238c cyp139 Probable cytochrome p450 Cyp139 (pseudogene) ML1238c, len: 171 bp. Possible pseudogene of M. tuberculosis orthologue Rv1666c|cyp139 (1293 bp) (Best blastx scores: 147). Yes intermediary metabolism and respiration Rv1666c Rv1666c AL450380.2 Mycobrowser_v4 CDS 1511584 1512033 . - 0 ML1268c bcpB Probable peroxidoxin BcpB (pseudogene) ML1268c, len: 450 bp. Possible pseudogene of M. tuberculosis orthologue bcpB|Rv1608c (465 bp) (Best blastx scores: 328). Yes virulence, detoxification, adaptation Rv1608c Rv1608c AL450380.2 Mycobrowser_v4 CDS 676303 677610 . + 0 ML0559 ribA Probable riboflavin biosynthesis protein RibA : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) ML0559, len: 435 aa. Probable ribA, Riboflavin biosynthesis protein (EC 3.5.4.25), highly similar to GCH2_MYCTU|P71684|Rv1415 ribA2, probable Riboflavin biosynthesis protein from M. tuberculosis (425 aa), Fasta scores: E(): 1.1e-171, (93.4% identity in 425 aa overlap); and CAD94311|Mb1450 from M. bovis (425 aa). Similar to many e.g. O24752|GCH2_CORAM Riboflavin biosynthesis protein ribA from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (423 aa), fasta scores: E(): 3.2e-105, (60.775% identity in 413 aa overlap). Contains Pfam match to entry PF00926 DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase. Contains Pfam match to entry PF00925 GTP_cyclohydro2, GTP cyclohydrolase II. IN THE N-TERMINAL SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II FAMILY. Q9CCP4 No intermediary metabolism and respiration PF00925,PF00926 Q9CCP4 GO:0003935,GO:0046872,GO:0009231,GO:0008686 3.5.4.25 Rv1415 Rv1415 AL450380.2 Mycobrowser_v4 CDS 955208 955729 . + 0 ML0806 ML0806 probable conserved integral membrane protein ML0806, len: 173 aa. Probable conserved integral membrane protein, highly similar but longer at the N terminus to Rv3217c|MTCY07D11.09|O05849|Z95120 conserved integral membrane protein from Mycobacterium tuberculosis (143 aa), fasta scores: E(): 1.3e-38, (77.1% identity in 140 aa); and CAD95335|Mb3243c from M. bovis (143 aa). Also similar to others e.g. Q9F3L9|2SC7G11.04 Putative integral membrane protein from Streptomyces coelicolor (152 aa), fasta scores: E(): 2.6e-05, (36.207% identity in 116 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CCH6 No cell wall and cell processes Q9CCH6 Rv3217c Rv3217c AL450380.2 Mycobrowser_v4 CDS 961969 962655 . + 0 ML0812 ML0812 Conserved hypothetical protein (pseudogene) ML0812, len: 687 bp. Possible pseudogene of M. tuberculosis orthologue Rv3210c (696 bp) (Best blastx scores: 523). Yes conserved hypotheticals Rv3210c Rv3210c AL450380.2 Mycobrowser_v4 CDS 968159 968447 . - 0 ML0819c ML0819c Possible DNA-methyltransferase (pseudogene) ML0819c, len: 289 bp. Possible pseudogene of M. tuberculosis orthologue Rv3204 (306 bp) (Best blastx scores: 245). Yes information pathways Rv3204 Rv3204 AL450380.2 Mycobrowser_v4 CDS 915145 915777 . + 0 ML0772 tmk probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) ML0772, len: 210 aa. Probable tmk, thymidylate kinase (EC 2.7.4.9), highly similar to MTCY20B11|Rv3247c|O05891|Z95121 Probable tmk, thymidylate kinase from Mycobacterium tuberculosis (214 aa), fasta scores: E(): 0, (77.3% identity in 207 aa); and CAD95367| from M. bovis (214 aa). Also similar to other thymidylate kinases e.g. Q8NSC3 Thymidylate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (203 aa), fasta scores: E(): 6.9e-29, (50.746% identity in 201 aa overlap); and KTHY_HUMAN|P23919 thymidylate kinase tymK from Homo sapiens fasta scores: E(): 0.005, (29.1% identity in 196 aa). Contains Pfam match to entry PF02223 Thymidylate_kin, Thymidylate kinase. Contains PS01331 Thymidylate kinase signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. BELONGS TO THE THYMIDYLATE KINASE FAMILY. Q9CCJ3 No intermediary metabolism and respiration PF02223 Q9CCJ3 GO:0006233,GO:0004798,GO:0005524 Rv3247c Rv3247c AL450380.2 Mycobrowser_v4 CDS 384334 385650 . + 0 ML0302 ML0302 Possible conserved membrane protein (pseudogene) ML0302, len: 1316 bp. Possible pseudogene of M. tuberculosis orthologue Rv0412c (1320 bp) (Best blastx scores: 1672) Yes cell wall and cell processes Rv0412c Rv0412c AL450380.2 Mycobrowser_v4 CDS 969796 972902 . + 0 ML0821 ML0821 Possible ATP-dependent DNA helicase (pseudogene) ML0821, len: 3107 bp. Possible pseudogene of M. tuberculosis orthologue Rv3202c (3168 bp) (Best blastx scores: 725). Yes information pathways Rv3202c Rv3202c AL450380.2 Mycobrowser_v4 CDS 949528 950330 . - 0 ML0800c ML0800c Probable iron-regulated short-chain dehydrogenase/reductase (pseudogene) ML0800c, len: 803 bp. Possible pseudogene of M. tuberculosis orthologue Rv3224 (849 bp) (Best blastx scores: 426). Yes intermediary metabolism and respiration Rv3224 Rv3224 AL450380.2 Mycobrowser_v4 CDS 950850 951069 . + 0 ML0801 sigH Alternative RNA polymerase sigma factor (ECF subfamily) SigH (pseudogene) ML0801, len: 220 bp. Possible pseudogene of M. tuberculosis orthologue sigH|Rv3223c (651 bp) (Best blastx scores: 162). Yes information pathways Rv3223c Rv3223c AL450380.2 Mycobrowser_v4 CDS 954250 955186 . - 0 ML0805c ML0805c Conserved hypothetical protein (pseudogene) ML0805c, len: 937 bp. Possible pseudogene of M. tuberculosis orthologue Rv3218 (966 bp) (Best blastx scores: 324). Yes conserved hypotheticals Rv3218 Rv3218 AL450380.2 Mycobrowser_v4 CDS 1309377 1309920 . - 0 ML1126c ML1126c Possible lipoprotein (pseudogene) ML1126c, len: 544 bp. Possible pseudogene similar to M. tuberculosis lpqQ|Rv0835 (645 bp) (Best blastx scores: 222). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1020472 1021416 . - 0 ML0858c lipA Probable lipoate biosynthesis protein A LipA ML0858c, len: 314 aa. Probable lipA, lipoic acid synthetase. Similar to Mycobacterium tuberculosis lipoic acid synthetase lipA or Rv2218 or MTCY190.29 SW:LIPA_MYCTU (Q10380) (311 aa) fasta scores: E(): 0, 86.5% identity in 310 aa. Similar to many e.g. Escherichia coli lipoic acid synthetase lipA or lip SW:LIPA_ECOLI (P25845; P77595) (321 aa) fasta scores: E(): 0, 42.5% identity in 294 aa. Previously sequenced as SW:LIPA_MYCLE (O32962). O32962 No intermediary metabolism and respiration PF04055 O32962 GO:0005737,GO:0005506,GO:0009107,GO:0016992,GO:0051539 2.8.1.8 Rv2218 Rv2218 AL450380.2 Mycobrowser_v4 CDS 475772 476080 . - 0 ML0382c whiB3 Probable transcriptional regulatory protein WhiB-like WhiB3 ML0382c, len: 102 aa. Probable whiB3 (alternate gene name: whmB), WhiB-like regulatory protein (see citations below), highly similar to Rv3416|Q50710|AL123456 whiB3, WhiB-like regulatory protein from M. tuberculosis (102 aa), Fasta scores: E(): 0, (86.3% identity in 102 aa overlap). Similar to many e.g. O88103|AJ010601 whiD, developmental regulatory gene from Streptomyces coelicolor (112 aa), Fasta scores: E(): 1.1e-24, (61.8% identity in 102 aa overlap). Previously sequenced as Q49871|U00015 (102 aa), Fasta scores: E(): 0, (100.0% identity in 102 aa overlap). Also similar to ML0760, ML0804 and ML2307 from M.leprae. Contains Pfam entry to PF02467, Transcription factor WhiB. Q49871 No regulatory proteins PF02467 Q49871 Rv3416 Rv3416 AL450380.2 Mycobrowser_v4 CDS 1524339 1526032 . - 0 ML1281c cydC Probable 'component linked with the assembly of cytochrome' transmembrane ATP-binding protein ABC transporter CydC (pseudogene) ML1281c, len: 1694 bp. Possible pseudogene of M. tuberculosis orthologue Rv1620c|cydC (1731 bp) (Best blastx scores: 430). Yes intermediary metabolism and respiration Rv1620c Rv1620c AL450380.2 Mycobrowser_v4 CDS 1470765 1473312 . + 0 ML1235 pks9 Probable polyketide synthase Pks9 (pseudogene) ML1235, len: 2548 bp. Possible pseudogene of M. tuberculosis orthologue pks9|Rv1664 (3054 bp) (Best blastx scores: 267). Yes lipid metabolism Rv1664 Rv1664 AL450380.2 Mycobrowser_v4 CDS 1346880 1348316 . - 0 ML1152c alkA Probable regulatory protein AlkA (pseudogene) ML1152c, len: 1437 bp. Possible pseudogene of M. tuberculosis orthologue alkA|Rv1317c (1491 bp) (Best blastx scores: 233). Yes information pathways Rv1317c Rv1317c AL450380.2 Mycobrowser_v4 CDS 1348503 1349672 . + 0 ML1153 ML1153 Possible oxidoreductase (pseudogene) ML1153, len: 1170 bp. Possible pseudogene similar to M. tuberculosis Rv0063 (1440 bp) (Best blastx scores: 343) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1747565 1747954 . - 0 ML1453c ML1453c conserved hypothetical protein ML1453c, len: 129 aa. Conserved hypothetical protein. Similar to a number of proteins of undefined function e.g. Mycobacterium tuberculosis Rv2420c TR:O86327 (EMBL:Z81368) (126 aa), Fasta scores: E(): 0, 87.0% identity in 123 aa overlap. Q9CBZ9 No conserved hypotheticals PF02410 Q9CBZ9 Rv2420c Rv2420c AL450380.2 Mycobrowser_v4 CDS 1327810 1328472 . + 0 ML1136 ML1136 conserved hypothetical protein ML1136, len: 220 aa. Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD01_MYCLE (P45831) (220 aa), Fasta scores: E(): 0, 99.5% identity in 220 aa overlap. Also highly similar to several other proteins of undefined function e.g. Mycobacterium tuberculosis Rv1301 SW:YD01_MYCTU (Q10618) (217 aa), Fasta scores: E(): 0, 83.3% identity in 215 aa overlap. Contains Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family. Contains PS01147 SUA5/yciO/yrdC family signature. P45831 No conserved hypotheticals PF01300 P45831 Rv1301 Rv1301 AL450380.2 Mycobrowser_v4 rRNA 1346189 1346304 . + 0 MLP000018 rrf 5S ribosomal RNA gene as assigned by Liesack W.C et al., (1991) FEBS Lett. 281:114-118 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 972941 975901 . + 0 ML0822 ML0822 Probable ATP-dependent DNA helicase (pseudogene) ML0822, len: 2961 bp. Possible pseudogene of M. tuberculosis orthologue Rv3201c (3306 bp) (Best blastx scores: 510) Yes information pathways Rv3201c Rv3201c AL450380.2 Mycobrowser_v4 CDS 981139 981420 . - 0 ML0827c ML0827c putative transposase (pseudogene) ML0827c, len: 282 bp. Possible pseudogene of a Tn3-type element transposase similar to Rv2355 Probable IS6110 transposase Yes insertion seqs and phages Rv2355 Rv2355 AL450380.2 Mycobrowser_v4 rRNA 1341147 1342695 . + 0 MLP000016 rrs 16S ribosomal RNA gene. As assigned by Sela S., Clark-Curtiss J.E. Gene 98:123-127 (1991) (EMBL:M58020) No stable RNAs AL450380.2 Mycobrowser_v4 CDS 1518433 1518669 . + 0 ML1275 ML1275 hypothetical protein ML1275, len: 78 aa. Hypothetical unknown protein. Q9CC51 No unknown Q9CC51 AL450380.2 Mycobrowser_v4 CDS 1092699 1093053 . - 0 ML0924c ML0924c Conserved hypothetical protein (pseudogene) ML0924c, len: 355 bp. Possible pseudogene of M. tuberculosis orthologue Rv2143 (1059 bp) (Best blastx scores: 106). Yes conserved hypotheticals Rv2143 Rv2143 AL450380.2 Mycobrowser_v4 CDS 1115200 1116010 . - 0 ML0945c bpoB Possible peroxidase BpoB (pseudogene) ML0945c, len: 811 bp. Possible pseudogene of M. tuberculosis orthologue bpoB|Rv1123c (909 bp) (Best blastx scores: 308). Yes virulence, detoxification, adaptation Rv1123c Rv1123c AL450380.2 Mycobrowser_v4 CDS 1157916 1159290 . - 0 ML0991c ML0991c Conserved hypothetical alanine and arginine rich protein (pseudogene) ML0991c, len: 1375 bp. Possible pseudogene of M. tuberculosis orthologue Rv2731 (1353 bp) (Best blastx scores: 491). Yes conserved hypotheticals Rv2731 Rv2731 AL450380.2 Mycobrowser_v4 CDS 1188117 1188450 . + 0 ML1020 ML1020 Conserved hypothetical protein (pseudogene) ML1020, len: 334 bp. Possible pseudogene of M. tuberculosis orthologue Rv2705c (390 bp) (Best blastx scores: 206). Yes conserved hypotheticals Rv2705c Rv2705c AL450380.2 Mycobrowser_v4 CDS 1188443 1188861 . - 0 ML1021c ML1021c Conserved hypothetical protein (pseudogene) ML1021c, len: 419 bp. Possible pseudogene of M. tuberculosis orthologue Rv2704 (429 bp) (Best blastx scores: 153). Yes conserved hypotheticals Rv2704 Rv2704 AL450380.2 Mycobrowser_v4 CDS 1212197 1212941 . - 0 ML1047c ML1047c Conserved hypothetical protein (pseudogene) ML1047c, len: 745 bp. Possible pseudogene similar to M. tuberculosis Rv3714c (891 bp) (Best blastx scores: 211). Identical to ML1943 and similar to ML2328c possible pseudogenes similar to M. tuberculosis Rv3714c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1245747 1246195 . - 0 ML1082c ML1082c Probable membrane protein (pseudogene) ML1082c, len: 449 bp. Possible pseudogene of M. tuberculosis orthologue Rv1231c (543 bp) (Best blastx scores: 179). Yes cell wall and cell processes Rv1231c Rv1231c AL450380.2 Mycobrowser_v4 CDS 1072705 1073838 . + 0 ML0907 ML0907 probable conserved membrane protein ML0907, len: 377 aa. Probable conserved membrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69559 (EMBL:AL022602) (377 aa), Fasta scores: E(): 0, 100.0% identity in 377 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis TR:O06213 (EMBL:Z95388) (384 aa), Fasta scores: E(): 0, 62.2% identity in 397 aa overlap. Contains a possible membrane spanning hydrophobic domain and a possible coiled-coil between residues 155..168. Q7AQC6 No cell wall and cell processes Q7AQC6 Rv2164c Rv2164c AL450380.2 Mycobrowser_v4 CDS 982492 983342 . + 0 ML0828 PPE PPE-family protein (pseudogene) ML0828, len: 851 bp. Possible pseudogene of M. tuberculosis PPE-family protein PPE38|Rv2352c (1176 bp) (Best blastx scores: 102). Yes PE/PPE Rv2352c Rv2352c AL450380.2 Mycobrowser_v4 CDS 983749 984270 . + 0 ML0829 plcA Probable membrane-associated phospholipase C 1 plcA (pseudogene) ML0829, len: 522 bp. Possible pseudogene of M. tuberculosis orthologue plcA|Rv2351c (Best blastx scores: 175) and similar to plcB and plcC. Yes intermediary metabolism and respiration Rv2351c Rv2351c AL450380.2 Mycobrowser_v4 CDS 984299 986301 . - 0 ML0830c ML0830c Possible conserved transmembrane protein (pseudogene) ML0830c, len: 2003 bp. Possible pseudogene of M. tuberculosis orthologue Rv2345 (1983 bp) (Best blastx scores: 503). Also similar to ML1265c a possible pseudogene similar to M. tuberculosis Rv2345 Yes cell wall and cell processes Rv2345 Rv2345 AL450380.2 Mycobrowser_v4 CDS 987877 988330 . + 0 ML0832 ML0832 Probable periplasmic superoxide dismutase (Cu-Zn) (pseudogene) ML0832, len: 454 bp. Possible pseudogene similar to M. tuberculosis sodC|Rv0432 (723 bp) (Best blastx scores: 163). Yes unknown AL450380.2 Mycobrowser_v4 CDS 990967 992730 . - 0 ML0835c mez Probable [NAD] dependent malate oxidoreductase Mez (pseudogene) ML0835c, len: 1764 bp. Possible pseudogene of M. tuberculosis orthologue mez|Rv2332 (1647 bp) (Best blastx scores: 299). Yes intermediary metabolism and respiration Rv2332 Rv2332 AL450380.2 Mycobrowser_v4 CDS 993464 993730 . + 0 ML0836 ML0836 Conserved hypothetical protein (pseudogene) ML0836, len: 267 bp. Possible pseudogene similar to bacterial hypothetical proteins e.g. TM0911|Q9X013|AE001755 from Thermotoga maritima. Yes unknown AL450380.2 Mycobrowser_v4 CDS 960120 961754 . - 0 ML0811c rhlE Probable ATP-dependent RNA helicase Rhle ML0811c, len: 544 aa. Probable ATP-dependent RNA helicase. Similar to O05855|Z95120|Rv3211|MTCY07D11.15c Mycobacterium tuberculosis putative ATP-dependent RNA helicase (407 aa), fasta scores: E(): 0, 74.8% identity in 531 aa, and to DEAD_KLEPN|P33906 Klebsiella pneumoniae ATP-dependent RNA helicase deaD fasta scores: E(): 0, 43.2% identity in 380 aa. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature. SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND SIMILAR TO HELICASE C-TERMINAL DOMAIN. Q9CCH3 No information pathways PF00270,PF00271 Q9CCH3 GO:0008026,GO:0003676,GO:0005524 Rv3211 Rv3211 AL450380.2 Mycobrowser_v4 CDS 1001911 1002398 . + 0 ML0843 lppP Probable lipoprotein LppP (pseudogene) ML0843, len: 488 bp. Possible pseudogene of M. tuberculosis orthologue lppP|Rv2330c (528 bp) (Best blastx scores: 294). Yes cell wall and cell processes Rv2330c Rv2330c AL450380.2 Mycobrowser_v4 CDS 1005525 1005851 . - 0 ML0847c ML0847c Conserved hypothetical protein (pseudogene) ML0847c, len: 327 bp. Possible pseudogene of M. tuberculosis orthologue Rv2327 (492 bp) (Best blastx scores: 184). Yes conserved hypotheticals Rv2327 Rv2327 AL450380.2 Mycobrowser_v4 CDS 997288 998592 . - 0 ML0840c ML0840c hypothetical protein ML0840c, len: 434 aa. Hypothetical unknown protein. Previously sequenced as O32977|Z98741. Q7AQF3 No unknown Q7AQF3 AL450380.2 Mycobrowser_v4 CDS 990404 990706 . - 0 ML0834c ML0834c conserved hypothetical protein ML0834c, len: 100 aa. Conserved hypothetical protein. Similar to Rv2342|MTCY98.11|P95238|Z83860 Mycobacterium tuberculosis hypothetical protein (85 aa), fasta scores: E(): 3e-21, 76.9% identity in 78 aa and shows weak similarity to Streptomyces coelicolor putative secreted protein SCC24.32|CAB86126|AL163003 (108 aa) fasta scores: E(): 0.035, 30.5% identity in 95 aa. Q9CCG1 No conserved hypotheticals Q9CCG1 Rv2342 Rv2342 AL450380.2 Mycobrowser_v4 CDS 1004103 1004684 . - 0 ML0845c ML0845c conserved hypothetical protein ML0845c, len: 193 aa. Conserved hypothetical protein. Similar to part of some acyl-CoA oxidases e.g. O65201|AF057043 Arabidopsis thaliana acyl-CoA oxidase cx2 (692 aa), fasta scores: E(): 1.5e-06, (35.2% identity in 125 aa). Previously sequenced as O32973|Z98741) (193 aa), fasta scores: E(): 0, (99.5% identity in 193 aa). Q7AQF1 No conserved hypotheticals Q7AQF1 GO:0003997,GO:0009055,GO:0006631,GO:0005777,GO:0050660 AL450380.2 Mycobrowser_v4 CDS 2249977 2251056 . - 0 ML1870c pqqE Probable coenzyme pqq synthesis protein E PqqE (pseudogene) ML1870c, len: 1080 bp. Possible pseudogene of M. tuberculosis orthologue pqqE|Rv0693 (1176 bp) (Best blastx scores: 555). Yes intermediary metabolism and respiration Rv0693 Rv0693 AL450380.2 Mycobrowser_v4 CDS 2138770 2138985 . + 0 ML1763 ML1763 hypothetical protein ML1763, len: 71 aa. Hypothetical unknown protein. Q9CBN9 No unknown Q9CBN9 AL450380.2 Mycobrowser_v4 CDS 1045991 1046860 . - 0 ML0881c qcrC Probable Ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) ML0881c, len: 289 aa. Probable qcrC, Ubiquinol-cytochrome C reductase. Similar to Mycobacterium tuberculosis ubiquinol-cytochrome C reductase cytochrome C subunit qcrC or Rv2194 or MTCY190.05 SW:QCRC_MYCTU (Q10386) (280 aa) fasta scores: E(): 0, 84.4% identity in 289 aa and to Streptomyces coelicolor cytochrome C heme-binding subunit SC6G10.23C TR:Q9X808 (EMBL:AL049497) (269 aa) fasta scores: E(): 0, 48.9% identity in 266 aa. Previously sequenced as SW:QCRC_MYCLE (O69583). Contains Pfam match to entry PF00034 cytochrome_c, Cytochrome c. Contains 2 x PS00190 Cytochrome C family heme-binding site signature. THE MAIN SUBUNITS OF THE UBIQUINOL:CYTOCHROME C COMPLEX ARE: CYTOCHROME B, THE RIESKE PROTEIN AND A CYTOCHROME C SUBUNIT. O69583 No intermediary metabolism and respiration PF00034 O69583 GO:0022900,GO:0020037,GO:0016021,GO:0005886,GO:0006810,GO:0009055 Rv2194 Rv2194 AL450380.2 Mycobrowser_v4 CDS 1101355 1101940 . + 0 ML0932 ML0932 Conserved hypothetical protein (pseudogene) ML0932, len: 586 bp. Possible pseudogene of M. tuberculosis orthologue Rv1815 (666 bp) (Best blastx scores: 237). Yes conserved hypotheticals Rv1815 Rv1815 AL450380.2 Mycobrowser_v4 CDS 1066281 1067327 . - 0 ML0900c idsA2 Probable geranylgeranyl pyrophosphate synthase IdsA2 (pseudogene) ML0900c, len: 1047 bp. Possible pseudogene of M. tuberculosis orthologue idsA2|Rv2173 (1059 bp) (Best blastx scores: 561). Yes lipid metabolism Rv2173 Rv2173 AL450380.2 Mycobrowser_v4 CDS 1055789 1056223 . + 0 ML0889 ML0889 CONSERVED HYPOTHETICAL PROTEIN TB16.3 HOMOLOG ML0889, len: 144 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2185c|O53519|AL021957 (144 aa), fasta scores: E(): 1.2e-50,(84.722% identity in 144 aa overlap). Previously sequenced as Mycobacterium leprae hypothetical protein O53519|AL021957 (144 aa), Fasta scores: E(): 0, 84.7% identity in 144 aa overlap. Q7AQE0 No conserved hypotheticals PF03364 Q7AQE0 Rv2185c Rv2185c AL450380.2 Mycobrowser_v4 CDS 1122422 1123023 . - 0 ML0954c ML0954c Conserved hypothetical protein (pseudogene) ML0954c, len: 602 bp. Possible pseudogene of M. tuberculosis orthologue Rv1126c (606 bp) (Best blastx scores: 364). Note the N-terminal region of this putative pseudogene was previously published O05567. Yes conserved hypotheticals Rv1126c Rv1126c AL450380.2 Mycobrowser_v4 CDS 1127280 1127739 . + 0 ML0960 ML0960 Conserved membrane protein (pseudogene) ML0960, len: 460 bp. Possible pseudogene of M. tuberculosis orthologue Rv1132 (1731 bp) (Best blastx scores: 183). Yes cell wall and cell processes Rv1132 Rv1132 AL450380.2 Mycobrowser_v4 CDS 1130785 1131104 . - 0 ML0962c ML0962c Possible transposase (pseudogene) ML0962c, len: 320 bp. Possible pseudogene similar to several M. tuberculosis IS1557 transposases e.g. Rv1313c, Rv3798 and Rv0741 (Best blastx scores: 152). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1133796 1134788 . - 0 ML0965c ML0965c Possible oxidoreductase (pseudogene) ML0965c, len: 993 bp. Possible pseudogene of M. tuberculosis orthologue Rv1138c (1017 bp) (Best blastx scores: 217). Yes intermediary metabolism and respiration Rv1138c Rv1138c AL450380.2 Mycobrowser_v4 CDS 1482136 1482597 . + 0 ML1243 lipQ PROBABLE CARBOXYLESTERASE LIPQ (PSEUDOGENE) ML1243, len: 153 aa. Possible pseudogene similar to M. tuberculosis Rv2485c (Best blastx score 118). Q9CC60 Yes intermediary metabolism and respiration Q9CC60 Rv2485c Rv2485c AL450380.2 Mycobrowser_v4 CDS 1079143 1080222 . + 0 ML0911 murX Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX ML0911, len: 359 aa. Probable murX, phospho-N-acetylmuramoyl-pentappeptidetransferase (EC 2.7.8.13). Identical to the previously sequenced Mycobacterium leprae phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) SW:MRAY_MYCLE (SW:O69555) (359 aa), Fasta scores: E(): 0, 100.0% identity in 359 aa overlap(SW:O69555). Also highly similar to phospho-N-acetylmuramoyl-pentapeptide-transferases from Mycobacterium tuberculosis Rv2156c SW:MRAY_MYCTU (SW:O06221) (359 aa), Fasta scores: E(): 0, 91.1% identity in 359 aa overlap(SW:O06221) and Escherichia coli SW:MRAY_ECOLI (SW:P15876) (360 aa), Fasta scores: E(): 6.2e-29, 35.9% identity in 343 aa overlap(SW:P15876). Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Contains Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase. O69555 No cell wall and cell processes PF00953,PF10555 O69555 GO:0051301,GO:0007047,GO:0016021,GO:0009252,GO:0008963,GO:0005886,GO:0008360,GO:0007049 2.7.8.13 Rv2156c Rv2156c AL450380.2 Mycobrowser_v4 CDS 1080224 1081696 . + 0 ML0912 murD Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD ML0912, len: 490 aa. Probable murD, UDP-N-acetylmuramoylalanine-D-glutamate ligase. Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylmuramoylalanine-D-glutamate ligase TR:O69554 (EMBL:AL022602) (490 aa), Fasta scores: E(): 0, 99.8% identity in 490 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:MURD_MYCTU (SW:O06222) (486 aa), Fasta scores: E(): 0, 75.9% identity in 493 aa overlap and Bacillus subtilis SW:MURD_BACSU (SW:Q03522) (451 aa), Fasta scores: E(): 7.1e-24, 28.4% identity in 493 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Belongs to the murCDEF family. P57995 No cell wall and cell processes PF02875,PF08245 P57995 GO:0008764,GO:0007049,GO:0051301,GO:0007047,GO:0005737,GO:0009252,GO:0008360,GO:0005524 6.3.2.9 Rv2155c Rv2155c AL450380.2 Mycobrowser_v4 CDS 1102571 1103269 . + 0 ML0933 ML0933 Possible transcriptional regulatory protein (pseudogene) ML0933, len: 699 bp. Possible pseudogene of M. tuberculosis orthologue Rv1816 (705 bp) (Best blastx scores: 526). Yes regulatory proteins Rv1816 Rv1816 AL450380.2 Mycobrowser_v4 CDS 1103997 1105282 . + 0 ML0934 ML0934 Possible flavoprotein (pseudogene) ML0934, len: 1286 bp. Possible pseudogene of M. tuberculosis orthologue Rv1817 (1464 bp) (Best blastx scores: 395). Yes intermediary metabolism and respiration Rv1817 Rv1817 AL450380.2 Mycobrowser_v4 CDS 1147169 1147711 . - 0 ML0978c ML0978c possible acetyltransferase ML0978c, len: 180 aa. Possible acetyltransferase (EC 2.-.-.-). Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa), Fasta scores: E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa), Fasta scores: E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa), Fasta scores: E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2747 TR:O33289 (EMBL:AL008967) (174 aa), Fasta scores: E(): 0, 86.2% identity in 174 aa overlap . Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. Q7AQC1 No intermediary metabolism and respiration PF00583 Q7AQC1 GO:0008152,GO:0008080 Rv2747 Rv2747 AL450380.2 Mycobrowser_v4 CDS 1151027 1151476 . - 0 ML0984c ML0984c conserved hypothetical protein. ML0984c, len: 149 aa. Conserved hypothetical protein. Almost identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49850 (EMBL:U00019) (178 aa), Fasta scores: E(): 0, 100.0% identity in 149 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2740 TR:O33283 (EMBL:AL008967) (149 aa), Fasta scores: E(): 3e-28, 52.0% identity in 150 aa overlap. Q9CCC2 No conserved hypotheticals, virulence, detoxification, adaptation PF07858 Q9CCC2 Rv2740 Rv2740 AL450380.2 Mycobrowser_v4 CDS 1197134 1197556 . + 0 ML1032 ML1032 Probable conserved integral membrane alanine and leucine rich protein (pseudogene) ML1032, len: 423 bp. Possible pseudogene of M. tuberculosis orthologue Rv2693c (672 bp) (Best blastx scores: 118). Yes cell wall and cell processes Rv2693c Rv2693c AL450380.2 Mycobrowser_v4 CDS 1166933 1168054 . + 0 ML0998 fadE20 Probable acyl-CoA dehydrogenase FadE20 (pseudogene) ML0998, len: 1122 bp. Possible pseudogene of M. tuberculosis orthologue fadE20|Rv2724c (1161 bp) (Best blastx scores: 404). Yes lipid metabolism Rv2724c Rv2724c AL450380.2 Mycobrowser_v4 CDS 1168383 1168736 . - 0 ML0999c ML0999c Possible transposase (pseudogene) ML0999c, len: 354 bp. Possible pseudogene similar to several M. tuberculosis IS6110 transposases e.g. Rv2355, Rv1369c, Rv3326, Rv3187 etc (Best blastx scores: 128). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1178460 1179494 . - 0 ML1008c ML1008c Probable hydrolase (pseudogene) ML1008c, len: 1035 bp. Possible pseudogene of M. tuberculosis orthologue Rv2715 (1026 bp) (Best blastx scores: 361). Yes intermediary metabolism and respiration Rv2715 Rv2715 AL450380.2 Mycobrowser_v4 CDS 1420622 1421599 . + 0 ML1204 ML1204 Possible fatty acyl CoA reductase (pseudogene) ML1204, len: 978 bp. Possible pseudogene of M. tuberculosis orthologue Rv1543 (1026 bp) (Best blastx scores: 277). Yes lipid metabolism Rv1543 Rv1543 AL450380.2 Mycobrowser_v4 CDS 1165273 1166739 . + 0 ML0997 hflX PROBABLE GTP-BINDING PROTEIN HFLX ML0997, len: 488 aa. Probable hflX, GTP-binding protein (EC 3.1.5.-). Identical to the previously sequenced Mycobacterium leprae HflX protein TR:Q49843 (EMBL:U00019) (518 aa), Fasta scores: E(): 0, 100.0% identity in 488 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2725c TR:O33230 (EMBLZ98209:) (495 aa), Fasta scores: E(): 0, 84.5% identity in 485 aa overlap and Escherichia coli GTP-binding protein HflX, located within the hflA (high frequency of lysogenization) locus governing lysis and lysogeny of bacteriophage lambda, SW:HFLX_ECOLI (P25519) (426 aa), Fasta scores: E(): 0, 38.3% identity in 428 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CCC0 No intermediary metabolism and respiration PF01926 Q9CCC0 GO:0005525,GO:0005622 Rv2725c Rv2725c AL450380.2 Mycobrowser_v4 CDS 1162623 1163321 . + 0 ML0994 ML0994 CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN ML0994, len: 232 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49835 (EMBL:U00019) (232 aa), Fasta scores: E(): 0, 99.6% identity in 232 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv2728c TR:O33233 (EMBL:Z98209) (231 aa), Fasta scores: E(): 0, 68.5% identity in 232 aa overlap and Streptomyces coelicolor TR:O69964 (EMBL:AL022268) (237 aa), Fasta scores: E(): 1.3e-13, 32.9% identity in 243 aa overlap. Q7AQB7 No conserved hypotheticals Q7AQB7 Rv2728c Rv2728c AL450380.2 Mycobrowser_v4 CDS 1181551 1182971 . - 0 ML1012c sthA Probable soluble pyridine nucleotide transhydrogenase SthA (pseudogene) ML1012c, len: 1421 bp. Possible pseudogene of M. tuberculosis orthologue Rv2713|sthA (1407 bp) (Best blastx scores: 507). Yes intermediary metabolism and respiration Rv2713 Rv2713 AL450380.2 Mycobrowser_v4 CDS 1187884 1188092 . + 0 ML1019 ML1019 Hypothetical protein (pseudogene) ML1019, len: 209 bp. Possible pseudogene of M. tuberculosis orthologue Rv2706c (258 bp) (Best blastx scores: 69). Yes conserved hypotheticals Rv2706c Rv2706c AL450380.2 Mycobrowser_v4 CDS 2251594 2252083 . + 0 ML1872 ML1872 Probable transcriptional regulatory protein (TetR/AcrR family) (pseudogene) ML1872, len: 490 bp. Possible pseudogene of M. tuberculosis orthologue Rv0691c (597 bp) (Best blastx scores: 122). Yes regulatory proteins Rv0691c Rv0691c AL450380.2 Mycobrowser_v4 CDS 1177173 1177658 . + 0 ML1006 ML1006 conserved hypothetical protein ML1006, len: 161 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49838 (EMBL:U00019) (138 aa), Fasta scores: E(): 0, 100.0% identity in 138 aa overlap. Note this CDS is 23 aa longer than the previously published sequence due to the assignment of the translational start site. Also highly similar to a number of other proteins of unknown function e.g. Mycobacterium tuberculosis Rv2717c TR:O07216 (EMBL:Z96072) (164 aa), Fasta scores: E(): 0, 73.8% identity in 164 aa overlap. Q9CCB8 No conserved hypotheticals PF08768 Q9CCB8 GO:0006810 Rv2717c Rv2717c AL450380.2 Mycobrowser_v4 CDS 1194838 1195659 . + 0 ML1029 ML1029 conserved hypothetical protein ML1029, len: 273 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49993 (EMBL:U15181) (273 aa), Fasta scores: E(): 0, 99.6% identity in 273 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2696c TR:O07198 (EMBL:Z96072) (259 aa), Fasta scores: E(): 0, 70.6% identity in 262 aa overlap. Q7AQA7 No conserved hypotheticals Q7AQA7 Rv2696c Rv2696c AL450380.2 Mycobrowser_v4 CDS 1195704 1196402 . - 0 ML1030c ML1030c conserved hypothetical protein ML1030c, len: 232 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49994 (EMBL:U15181) (232 aa), Fasta scores: E(): 0, 99.6% identity in 232 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2695 TR:O07197 (EMBL:Z96072) (235 aa), Fasta scores: E(): 0, 76.5% identity in 230 aa overlap. Q7AQA6 No conserved hypotheticals Q7AQA6 Rv2695 Rv2695 AL450380.2 Mycobrowser_v4 CDS 1284316 1285506 . + 0 ML1110 ML1110 Conserved hypothetical protein (pseudogene) ML1110, len: 1191 bp. Possible pseudogene of M. tuberculosis orthologue Rv0074 (1236 bp) (Best blastx scores: 257). Yes conserved hypotheticals Rv0074 Rv0074 AL450380.2 Mycobrowser_v4 CDS 1791960 1792501 . - 0 ML1487c ML1487c Probable conserved integral membrane alanine, valine and leucine rich protein (pseudogene) ML1487c, len: 542 bp. Possible pseudogene similar to M. tuberculosis Rv2690c (1974 bp) (Best blastx scores: 112). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1214210 1215451 . - 0 ML1048c ML1048c Possible transposase (pseudogene) ML1048c, len: 1242 bp. Possible pseudogene similar to several M. tuberculosis transposases e.g. Rv2885c, Rv2791, Rv0606, Rv3827 and Rv2978 (Best blastx scores: 388). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1215475 1216057 . - 0 ML1049c ML1049c Possible resolvase (pseudogene) ML1049c, len: 583 bp. Possible pseudogene similar to several M. tuberculosis possible resolvases e.g. Rv2886, Rv0605, Rv3828, Rv2979 and Rv2792 (Best blastx scores: 329). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1216313 1217035 . + 0 ML1050 ML1050 Conserved hypothetical protein (pseudogene) ML1050, len: 723 bp. Possible pseudogene of M. tuberculosis orthologue Rv1191 (915 bp) (Best blastx scores: 177). Yes conserved hypotheticals Rv1191 Rv1191 AL450380.2 Mycobrowser_v4 CDS 1220733 1221370 . + 0 ML1054 PPE PPE-family protein (pseudogene) ML1054, len: 638 bp. Possible pseudogene of M. tuberculosis PPE18|Rv1196 (1176 bp) (Best blastx scores: 821). Also similar to ML1182c a possible orthologue of M. tuberculosis Rv1196. Yes PE/PPE Rv1196 Rv1196 AL450380.2 Mycobrowser_v4 CDS 1224796 1226256 . - 0 ML1060c ML1060c Conserved hypothetical protein (pseudogene) ML1060c, len: 1461 bp. Possible pseudogene of M. tuberculosis orthologue Rv1204c (1689 bp) (Best blastx scores: 256). Yes conserved hypotheticals Rv1204c Rv1204c AL450380.2 Mycobrowser_v4 CDS 1227059 1228576 . + 0 ML1062 fadD6 Probable fatty-acid-CoA ligase ligase FadD6 (pseudogene) ML1062, len: 1518 bp. Possible pseudogene of M. tuberculosis orthologue fadD6|Rv1206 (1794 bp) (Best blastx scores: 281). Yes lipid metabolism Rv1206 Rv1206 AL450380.2 Mycobrowser_v4 CDS 1236833 1237671 . - 0 ML1073c ML1073c Probable tetronasin-transport ATP-binding protein ABC transporter (pseudogene) ML1073c, len: 839 bp. Possible pseudogene of M. tuberculosis orthologue Rv1218c (936 bp) (Best blastx scores: 278). Yes cell wall and cell processes Rv1218c Rv1218c AL450380.2 Mycobrowser_v4 CDS 1237771 1238312 . - 0 ML1074c ML1074c Probable transcriptional regulatory protein (pseudogene) ML1074c, len: 542 bp. Possible pseudogene of M. tuberculosis orthologue Rv1219c (639 bp) (Best blastx scores: 232). Yes regulatory proteins Rv1219c Rv1219c AL450380.2 Mycobrowser_v4 CDS 1221436 1221738 . + 0 ML1055 esxK1 ESAT-6 LIKE PROTEIN ESXK1 (ESAT-6 LIKE PROTEIN 3) ML1055, len: 100 aa. Probable esxK1, esat-6 like protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49945 (EMBL:U15180) (100 aa), Fasta scores: E(): 0, 100.0% identity in 100 aa overlap. Also similar to several proteins of undefined function from Mycobacterium tuberculosis e.g. TR:O05299 (EMBL:Z93777) (98 aa), Fasta scores: E(): 1.7e-20, 58.3% identity in 96 aa overlap. Identical to ML1181c a possible paralogue of M. tuberculosis esxK. Q49945 No cell wall and cell processes Q49945 Rv1197 Rv1197 AL450380.2 Mycobrowser_v4 CDS 1245009 1245563 . - 0 ML1081c ML1081c Possible membrane protein (pseudogene) ML1081c, len: 555 bp. Possible pseudogene of M. tuberculosis orthologue Rv1230c (1236 bp) (Best blastx scores: 149). Yes cell wall and cell processes Rv1230c Rv1230c AL450380.2 Mycobrowser_v4 CDS 1246854 1247468 . - 0 ML1084c ML1084c Conserved hypothetical membrane protein (pseudogene) ML1084c, len: 615 bp. Possible pseudogene of M. tuberculosis orthologue Rv1233c (597 bp) (Best blastx scores: 522). Yes cell wall and cell processes Rv1233c Rv1233c AL450380.2 Mycobrowser_v4 CDS 1247772 1248299 . + 0 ML1085 ML1085 Probable transmembrane protein (pseudogene) ML1085, len: 528 bp. Possible pseudogene of M. tuberculosis orthologue Rv1234 (528 bp) (Best blastx scores: 132). Yes cell wall and cell processes Rv1234 Rv1234 AL450380.2 Mycobrowser_v4 CDS 1238389 1239063 . - 0 ML1075c ML1075c PROBABLE METHYLTRANSFERASE ML1075c, len: 224 aa. Probable methyltransferase (EC 2.1.1.-). Previously sequenced Mycobacterium leprae TR:Q49969 (EMBL:U15180) (136 aa), Fasta scores: E(): 0, 100.0% identity in 136 aa overlap. Also highly similar to Mycobacterium tuberculosis possible methyltransferase Rv1220c TR:O33219 (EMBL:Z98260) (215 aa), Fasta scores: E(): 0, 85.5% identity in 214 aa overlap and Streptomyces mycarofaciens O-methyltransferase (EC 2.1.1.-) involved in the synthesis of the macrolide antibiotic midecamycin SW:MDMC_STRMY (Q00719) (221 aa), Fasta scores: E(): 2.3e-11, 30.5% identity in 223 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3, O-methyltransferase. Q9CCA7 No intermediary metabolism and respiration PF01596 Q9CCA7 GO:0008171 Rv1220c Rv1220c AL450380.2 Mycobrowser_v4 CDS 1257732 1258589 . + 0 ML1093 lpqZ PROBABLE LIPOPROTEIN LPQZ ML1093, len: 285 aa. Probable lpqZ lipoprotein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49982 (EMBL:U15180) (227 aa), Fasta scores: E(): 0, 100.0% identity in 227 aa overlap. Also highly similar to Mycobacterium tuberculosis lipoprotein Rv1244, TR:O50459 (EMBL:AL021006) (286 aa), Fasta scores: E(): 0, 73.5% identity in 287 aa overlap and weakly similar to several others e.g. Streptomyces coelicolor TR:Q9X832 (EMBL:AL049727) (320 aa), Fasta scores: E(): 2.9, 26.1% identity in 299 aa overlap putative secreted substrate-binding protein. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CC99 No cell wall and cell processes PF04069 Q9CC99 GO:0006810,GO:0005215,GO:0005488 Rv1244 Rv1244 AL450380.2 Mycobrowser_v4 CDS 1294766 1295917 . + 0 ML1119 ML1119 CONSERVED HYPOTHETICAL PROTEIN ML1119, len: 383 aa. Conserved hypothetical protein. Highly similar but shorter to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa), Fasta scores: E(): 0, 82.0% identity in 383 aa overlap. Q9CC84 No conserved hypotheticals PF00149 Q9CC84 GO:0016787 Rv1277 Rv1277 AL450380.2 Mycobrowser_v4 CDS 1303219 1304118 . - 0 ML1123c oppC PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER OPPC ML1123c, len: 299 aa. Probable oppC, oligopeptide-transport integral membrane protein ABC transporter. Highly similar to many membrane transport proteins e.g. Mycobacterium tuberculosis putative peptide transport permease Rv1282c SW:YC82_MYCTU (Q10623) (291 aa), Fasta scores: E(): 0, 82.6% identity in 287 aa overlap and Escherichia coli SW:OPPC_ECOLI (P77664) (302 aa), Fasta scores: E(): 0, 38.8% identity in 289 aa overlap oligopeptide transport system permease protein. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. Q9CC80 No cell wall and cell processes PF00528 Q9CC80 GO:0005886,GO:0006810,GO:0005215,GO:0016021 Rv1282c Rv1282c AL450380.2 Mycobrowser_v4 CDS 1610687 1611373 . - 0 ML1350c ML1350c Probable conserved ATP-binding protein ABC transporter (pseudogene) ML1350c, len: 687 bp. Possible pseudogene of M. tuberculosis orthologue Rv1687c (768 bp) (Best blastx scores: 515). Yes cell wall and cell processes Rv1687c Rv1687c AL450380.2 Mycobrowser_v4 CDS 1387518 1388409 . - 0 ML1187c ML1187c Probable fatty-acid-CoA ligase (pseudogene) ML1187c, len: 892 bp. Possible pseudogene similar to several M. tuberculosis fatty-acid-CoA synthetases e.g. fadD4|Rv0214, fadD8|Rv0551c, fadD12|Rv1427c etc (Best blastx scores: 98). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1408810 1410075 . - 0 ML1194c ML1194c Probable conserved polyketide synthase associated protein (pseudogene) ML1194c, len: 1266 bp. Possible pseudogene similar to several M. tuberculosis probable polyketide synthases e.g. papA1|Rv3824c, papA3|Rv1182 and papA2|Rv3820c (Best blastx scores: 212). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1323334 1325166 . + 0 ML1132 rho PROBABLE TRANSCRIPTION TERMINATION FACTOR RHO HOMOLOG ML1132, len: 610 aa. Probable transcription termination factor rho homolog. Identical to the previously sequenced Mycobacterium leprae transcription termination factor Rho SW:RHO_MYCLE (P45835) (610 aa), Fasta scores: E(): 0, 99.8% identity in 610 aa overlap. Also highly similar to many other transcriptional terminators including: Mycobacterium tuberculosis Rv1297 SW:RHO_MYCTU (Q10607) (602 aa), Fasta scores: E(): 0, 81.5% identity in 616 aa overlap and Micrococcus luteus SW:RHO_MICLU (P52154) (690 aa), Fasta scores: E(): 0, 66.0% identity in 467 aa overlap. Contains Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family. P45835 No information pathways PF00006,PF07497,PF07498 P45835 GO:0015986,GO:0003723,GO:0004386,GO:0016820,GO:0033178,GO:0006355,GO:0006353,GO:0003715,GO:0005524 3.6.1.- Rv1297 Rv1297 AL450380.2 Mycobrowser_v4 rRNA 1342979 1346103 . + 0 MLP000017 rrl 23S ribosomal RNA gene as assigned by Liesack W.C et al., (1991) FEBS Lett. 281:114-118 No stable RNAs AL450380.2 Mycobrowser_v4 CDS 1814658 1814990 . - 0 ML1503c mutT2 Probable mutator protein MutT (pseudogene) ML1503c, len: 333 bp. Possible pseudogene of M. tuberculosis orthologue mutT2|Rv1160 (426 bp) (Best blastx scores: 187). Q9CBX1 Yes information pathways Q9CBX1 GO:0006729,GO:0008124 4.2.1.96 Rv1160 Rv1160 AL450380.2 Mycobrowser_v4 CDS 1438004 1438257 . - 0 ML1215c ML1215c Probable hypothetical membrane protein (pseudogene) ML1215c, len: 254 bp. Possible pseudogene of M. tuberculosis orthologue Rv1567c (285 bp) (Best blastx scores: 76). Yes cell wall and cell processes Rv1567c Rv1567c AL450380.2 Mycobrowser_v4 CDS 1432450 1434638 . - 0 ML1212c treX Probable maltooligosyltrehalose synthase TreX (pseudogene) ML1212c, len: 2189 bp. Possible pseudogene of M. tuberculosis orthologue treX|Rv1564c (2166 bp) (Best blastx scores: 387). Yes virulence, detoxification, adaptation Rv1564c Rv1564c AL450380.2 Mycobrowser_v4 CDS 1355244 1357421 . - 0 ML1160c glgB Probable 1,4-[alpha]-glucan branching enzyme GlgB (pseudogene) ML1160c, len: 2178 bp. Possible pseudogene of M. tuberculosis orthologue glgB|Rv1326c (2196 bp) (Best blastx scores: 959). Yes intermediary metabolism and respiration Rv1326c Rv1326c AL450380.2 Mycobrowser_v4 CDS 1351362 1352024 . + 0 ML1155 ML1155 conserved hypothetical protein ML1155, len: 220 aa. Conserved hypothetical protein. Previously sequenced Mycobacterium leprae hypothetical protein SW:YD21_MYCLE (P53524) (201 aa), Fasta scores: E(): 0, 99.5% identity in 193 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1321 SW:YD21_MYCTU (Q10634) (226 aa), Fasta scores: E(): 0, 88.2% identity in 220 aa overlap. Contains Pfam match to entry PF01939 DUF91, Protein of unknown function. P53524 No conserved hypotheticals PF01939 P53524 Rv1321 Rv1321 AL450380.2 Mycobrowser_v4 CDS 1364615 1364941 . + 0 ML1165 ML1165 conserved hypothetical protein ML1165, len: 108 aa. Conserved hypothetical protein. Previously sequenced Mycobacterium leprae hypothetical protein SW:YD31_MYCLE (P53423) (94 aa), Fasta scores: E(): 0, 98.9% identity in 94 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv1331 SW:YD31_MYCTU (Q10642) (101 aa), Fasta scores: E(): 0, 84.2% identity in 101 aa overlap and Streptomyces coelicolor TR:Q9S2G5 (EMBL:AL096852) (105 aa), Fasta scores: E(): 1.4e-20, 56.7% identity in 104 aa overlap. P53423 No conserved hypotheticals PF02617 P53423 GO:0006508 Rv1331 Rv1331 AL450380.2 Mycobrowser_v4 CDS 1868327 1870347 . + 0 ML1545 malQ Probable 4-alpha-glucanotransferase MalQ (pseudogene) ML1545, len: 2021 bp. Possible pseudogene of M. tuberculosis orthologue Rv1781c|malQ (2175 bp) (Best blastx scores: 285). Yes intermediary metabolism and respiration Rv1781c Rv1781c AL450380.2 Mycobrowser_v4 CDS 2264715 2265475 . - 0 ML1886c ML1886c Conserved hypothetical protein (pseudogene) ML1886c, len: 761 bp. Possible pseudogene of M. tuberculosis orthologue Rv0674 (723 bp) (Best blastx scores: 207). Yes conserved hypotheticals Rv0674 Rv0674 AL450380.2 Mycobrowser_v4 CDS 1368495 1369211 . + 0 ML1171 ML1171 PROBABLE INTEGRAL MEMBRANE PROTEIN ML1171, len: 238 aa. Probable conserved integral membrane protein. Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa), Fasta scores: E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa), Fasta scores: E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. P53426 No cell wall and cell processes PF01694 P53426 GO:0005886,GO:0016021 Rv1337 Rv1337 AL450380.2 Mycobrowser_v4 CDS 1414681 1416057 . + 0 ML1197 dinX Probable DNA polymerase IV DinX (pseudogene) ML1197, len: 1377 bp. Possible pseudogene of M. tuberculosis orthologue dinX|Rv1537 (1392 bp) (Best blastx scores: 489). Yes information pathways Rv1537 Rv1537 AL450380.2 Mycobrowser_v4 CDS 1418702 1419340 . - 0 ML1201c ML1201c Hypothetical protein (pseudogene) ML1201c, len: 639 bp. Possible pseudogene similar to M. tuberculosis Rv1597 (759 bp) (Best blastx scores: 186). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1419487 1419931 . - 0 ML1202c lprI Possible lipoprotein LprI (pseudogene) ML1202c, len: 445 bp. Possible pseudogene of M. tuberculosis orthologue lprI|Rv1541c (594 bp) (Best blastx scores: 128). Yes cell wall and cell processes Rv1541c Rv1541c AL450380.2 Mycobrowser_v4 CDS 1386779 1387081 . - 0 ML1186c ML1186c hypothetical protein ML1186c, len: 100 aa. Hypothetical unknown protein. Q9CC71 No unknown Q9CC71 AL450380.2 Mycobrowser_v4 CDS 1392496 1392879 . - 0 ML1189c ML1189c hypothetical protein ML1189c, len: 127 aa. Hypothetical unknown protein, identical to the previously sequenced Q9X7D8 Mycobacterium leprae hypothetical protein (127 aa). Q7AQ87 No unknown Q7AQ87 AL450380.2 Mycobrowser_v4 CDS 1390598 1390858 . - 0 ML1188c ML1188c hypothetical protein ML1188c, len: 86 aa. Hypothetical unknown protein. Similar in part to several putative GntR-family transcriptional regulators e.g. Q88DT5 Transcriptional regulator, GntR family from Pseudomonas putida (255 aa), fasta scores: E(): 0.061, (36.047% identity in 86 aa overlap). Q9CC70 No unknown Q9CC70 GO:0006355,GO:0003700,GO:0005622 AL450380.2 Mycobrowser_v4 CDS 1441748 1442260 . + 0 ML1219 ML1219 Conserved hypothetical protein (pseudogene) ML1219, len: 513 bp. Possible pseudogene of M. tuberculosis orthologue Rv1571 (510 bp) (Best blastx scores: 374). Yes conserved hypotheticals Rv1571 Rv1571 AL450380.2 Mycobrowser_v4 CDS 1875366 1875882 . - 0 ML1551c ML1551c Conserved hypothetical protein (pseudogene) ML1551c, len: 517 bp. Possible pseudogene of M. tuberculosis orthologue Rv2825c (648 bp) or Rv2828c (546 bp) (Best blastx scores: 313). Yes conserved hypotheticals Rv2825c,Rv2828c Rv2825c,Rv2828c AL450380.2 Mycobrowser_v4 CDS 1444492 1445668 . - 0 ML1223c ML1223c Conserved hypothetical protein (pseudogene) ML1223c, len: 1177 bp. Possible pseudogene of M. tuberculosis orthologue Rv1592c (1341 bp) (Best blastx scores: 313). Yes conserved hypotheticals Rv1592c Rv1592c AL450380.2 Mycobrowser_v4 CDS 1453268 1454046 . + 0 ML1228 ML1228 Probable esterase (pseudogene) ML1228, len: 779 bp. Possible pseudogene similar to several M. tuberculosis esterases e.g. lipO|Rv1426c, lipM|Rv2284 and lipQ|Rv2485c etc (Best blastx scores: 158). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2994502 2995069 . - 0 ML2514c ML2514c Probable integral membrane protein (pseudogene) ML2514c, len: 568 bp. Possible pseudogene similar to M. tuberculosis Rv3481c (690 bp) (Best blastx scores: 152) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1498709 1499356 . + 0 ML1254 ML1254 conserved hypothetical protein ML1254, len: 215 aa. Conserved hypothetical protein. Highly similar to several proteins of unknown function including: Mycobacterium tuberculosis Rv2469c TR:O53196 (EMBL:AL021246) (222 aa), Fasta scores: E(): 0, 77.9% identity in 222 aa overlap and Streptomyces coelicolor TR:CAB71830 (EMBL:AL138662) (178 aa), Fasta scores: E(): 0, 52.8% identity in 161 aa overlap. Contains Pfam match to entry PF01844 HNH, HNH endonuclease. Q7AQ78 No conserved hypotheticals PF01844 Q7AQ78 GO:0003676,GO:0004519 Rv2469c Rv2469c AL450380.2 Mycobrowser_v4 CDS 1437013 1437651 . - 0 ML1214c ML1214c Possible invasion protein (NLP/P60 family protein) ML1214c, len: 212 aa. Possible inv protein, probably exported as has QQAPV repeats at C-terminus. Previously sequenced Mycobacterium leprae TR:Q49634 (EMBL:U00010) (246 aa), Fasta scores: E(): 0, 100.0% identity in 206 aa overlap. This predicted product of this CDS is similar to several including a portion of Listeria monocytogenes SW:P60_LISMO (P21171) (484 aa), Fasta scores: E(): 0.0013, 29.7% identity in 148 aa overlap invasion-associated protein P60 and several other proteins of undefined function e.g. Mycobacterium tuberculosis Rv1566c TR:O06624 (EMBL:Z95586) (230 aa), Fasta scores: E(): 0, 69.4% identity in 209 aa overlap. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Q9CC67 No virulence, detoxification, adaptation PF00877 Q9CC67 Rv1566c Rv1566c AL450380.2 Mycobrowser_v4 CDS 1475276 1475717 . - 0 ML1239c ML1239c Probable second part of macrolide-transport ATP-binding protein ABC transporter (pseudogene) ML1239c, len: 442 bp. Possible pseudogene of M. tuberculosis orthologue Rv1667c (654 bp) (Best blastx scores: 184). Yes cell wall and cell processes Rv1667c Rv1667c AL450380.2 Mycobrowser_v4 CDS 1475429 1476053 . - 0 ML1240c ML1240c Probable first part of macrolide-transport ATP-binding protein ABC transporter (pseudogene) ML1240c, len: 625 bp. Possible pseudogene of M. tuberculosis orthologue Rv1668c (1119 bp) (Best blastx scores: 93). Yes cell wall and cell processes Rv1668c Rv1668c AL450380.2 Mycobrowser_v4 CDS 1478296 1480178 . + 0 ML1242 ML1242 Probable transcriptional regulatory protein (LuxR/UhpA family) (pseudogene) ML1242, len: 1883 bp. Possible pseudogene similar to M. tuberculosis Rv0386 (3258 bp) (Best blastx scores: 259). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1480632 1480794 . + 0 ML1242A ML1242A Probable transposase (pseudogene) ML1242A, len: 163 bp. Possible pseudogene similar to several M. tuberculosis transposases associated with IS6110 (Best blastx scores: 75) and identical to ML1291c, ML0599A, ML1820A, ML0568B from M. leprae. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1488722 1489018 . + 0 ML1247 ML1247 Conserved hypothetical protein (pseudogene) ML1247, len: 297 bp. Possible pseudogene of M. tuberculosis orthologue Rv2478c (486 bp) (Best blastx scores: 155). Yes conserved hypotheticals Rv2478c Rv2478c AL450380.2 Mycobrowser_v4 CDS 1495767 1496158 . + 0 ML1250 ML1250 Conserved hypothetical protein (pseudogene) ML1250, len: 392 bp. Possible pseudogene of M. tuberculosis orthologue Rv2475c (417 bp) (Best blastx scores: 137). Yes conserved hypotheticals Rv2475c Rv2475c AL450380.2 Mycobrowser_v4 CDS 1496183 1496718 . + 0 ML1251 ML1251 Conserved hypothetical protein (pseudogene) ML1251, len: 536 bp. Possible pseudogene of M. tuberculosis orthologue Rv2474c (654 bp) (Best blastx scores: 207). Yes conserved hypotheticals Rv2474c Rv2474c AL450380.2 Mycobrowser_v4 CDS 1496788 1498136 . - 0 ML1252c aglA Probable maltase [alpha]-glucosidase AglA (pseudogene) ML1252c, len: 1349 bp. Possible pseudogene of M. tuberculosis orthologue Rv2471|aglA (1641 bp) (Best blastx scores: 408). Yes intermediary metabolism and respiration Rv2471 Rv2471 AL450380.2 Mycobrowser_v4 CDS 1501773 1502186 . - 0 ML1256c ML1256c Conserved hypothetical protein (pseudogene) ML1256c, len: 414 bp. Possible pseudogene of M. tuberculosis orthologue Rv1598c (411 bp) (Best blastx scores: 161). Yes conserved hypotheticals Rv1598c Rv1598c AL450380.2 Mycobrowser_v4 CDS 2856452 2856783 . + 0 ML2386 ML2386 Probable transmembrane protein (pseudogene) ML2386, len: 332 bp. Possible pseudogene of M. tuberculosis orthologue Rv0461 (525 bp) (Best blastx scores: 118). Yes cell wall and cell processes Rv0461 Rv0461 AL450380.2 Mycobrowser_v4 CDS 1482820 1484295 . + 0 ML1244 ML1244 CONSERVED HYPOTHETICAL PROTEIN ML1244, len: 491 aa. Conserved hypothetical protein. Highly similar to a family of Mycobacterium tuberculosis proteins e.g. Rv2484c SW:YO84_MYCTU (O53209) (491 aa), Fasta scores: E(): 0, 75.2% identity in 483 aa overlap. Q7AQ82 No cell wall and cell processes, lipid metabolism PF03007 Q7AQ82 Rv2484c Rv2484c AL450380.2 Mycobrowser_v4 CDS 1508362 1508709 . + 0 ML1264 hisI Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI ML1264, len: 115 aa. Probable hisI, phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19). Highly similar to many phosphoribosyl-AMP cyclohydrolases involved in histidine biosynthesis including: Mycobacterium tuberculosis Rv1606 SW:HIS3_MYCTU (O53909) (115 aa), Fasta scores: E(): 0, 84.3% identity in 115 aa overlap and Bacillus subtilis SW:HIS2_BACSU (O34912) (209 aa), Fasta scores: E(): 6.3e-18, 50.0% identity in 98 aa overlap. Contains Pfam match to entry PF01502 PRA-CH, Phosphoribosyl-AMP cyclohydrolase. Q9X7C3 No intermediary metabolism and respiration PF01502 Q9X7C3 GO:0000105,GO:0004635,GO:0005737 3.5.4.19 Rv1606 Rv1606 AL450380.2 Mycobrowser_v4 CDS 2886194 2886538 . + 0 ML2415 ML2415 Conserved hypothetical protein (pseudogene) ML2415, len: 345 bp. Possible pseudogene of M. tuberculosis orthologue Rv0523c (396 bp) (Best blastx scores: 205). Yes conserved hypotheticals Rv0523c Rv0523c AL450380.2 Mycobrowser_v4 CDS 1499771 1500262 . + 0 ML1255 ML1255 conserved hypothetical protein ML1255, len: 163 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2468c TR:O53195 (EMBL:AL021246) (167 aa), Fasta scores: E(): 0, 81.2% identity in 165 aa overlap. Q9CC58 No conserved hypotheticals Q9CC58 Rv2468c Rv2468c AL450380.2 Mycobrowser_v4 CDS 1526116 1527672 . - 0 ML1282c cydD Probable 'component linked with the assembly of cytochrome' transmembrane ATP-binding protein ABC transporter CydD (pseudogene) ML1282c, len: 1557 bp. Possible pseudogene of M. tuberculosis orthologue Rv1621c|cydD (1584 bp) (Best blastx scores: 679). Yes intermediary metabolism and respiration Rv1621c Rv1621c AL450380.2 Mycobrowser_v4 CDS 1521269 1522162 . + 0 ML1278 tesB Probable acyl-CoA thioesterase II TesB ML1278, len: 297 aa. Probable acyl-CoA thioesterase II (EC 3.1.2.-). Highly similar to many acyl CoA thioesterases including: Escherichia coli SW:TESB_ECOLI (P23911) (285 aa), Fasta scores: E(): 5.6e-26, 32.1% identity in 287 aa overlap and Mycobacterium tuberculosis Rv1618 TR:O06135 (EMBL:Z95554) (300 aa), Fasta scores: E(): 0, 85.1% identity in 288 aa overlap. Q9CC48 No lipid metabolism PF02551 Q9CC48 GO:0016291,GO:0006637 Rv1618 Rv1618 AL450380.2 Mycobrowser_v4 CDS 1828949 1829973 . - 0 ML1515c hsdS Possible type I restriction/modification system specificity determinant HsdS (pseudogene) ML1515c, len: 1025 bp. Possible pseudogene of M. tuberculosis orthologue Rv2761c|hsdS (1095 bp) (Best blastx scores: 328). Yes information pathways Rv2761c Rv2761c AL450380.2 Mycobrowser_v4 CDS 1716928 1717254 . + 0 ML1430 ML1430 Possible integral membrane protein ML1430, len: 108 aa. Possible integral membrane protein. Similar to Q9KZZ3|AL353815 Putative integral membrane protein from Streptomyces coelicolor (136 aa), Fasta scores: E(): 9.5e-15, (52.4% identity in 105 aa overlap). Contains possible membrane spanning hydrophobic domains. Q9CC06 No cell wall and cell processes Q9CC06 AL450380.2 Mycobrowser_v4 CDS 1330423 1331178 . + 0 ML1139 atpB PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) ML1139, len: 251 aa. Probable atpB, ATP synthase A chain protein (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase A chain (EC 3.6.1.34) SW:ATP6_MYCLE (P45829) (251 aa), Fasta scores: E(): 0, 100.0% identity in 251 aa overlap. Also highly similar to many other Prokaryotic and Eukaryotic proposed ATPase A chain family proteins e.g. Mycobacterium tuberculosis Rv1304 SW:ATP6_MYCTU (Q10591) (250 aa), Fasta scores: E(): 0, 84.0% identity in 250 aa overlap and Nicotiana tabacum (Common tobacco) SW:ATPI_TOBAC (P06288) (247 aa), Fasta scores: E(): 3.3e-18, 32.5% identity in 246 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00119 ATP-synt_A, ATP synthase A chain. Contains PS00449 ATP synthase a subunit signature. P45829 No intermediary metabolism and respiration PF00119 P45829 GO:0016021,GO:0005886,GO:0042777,GO:0045263,GO:0046933 Rv1304 Rv1304 AL450380.2 Mycobrowser_v4 CDS 1337568 1337933 . + 0 ML1146 atpC PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC ML1146, len: 121 aa. Probable atpC, ATP synthase [epsilon] chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase epsilon chain SW:ATPE_MYCLE (P45822) (124 aa), Fasta scores: E(): 0, 100.0% identity in 121 aa overlap. Also highly similar to many other proposed ATPase epsilon chain family proteins e.g. Mycobacterium tuberculosis Rv1311 SW:ATPE_MYCTU (Q10595) (121 aa), Fasta scores: E(): 0, 87.6% identity in 121 aa overlap and Bacillus firmus SW:ATPE_BACFI (P22480) (133 aa), Fasta scores: E(): 6.3e-09, 41.3% identity in 104 aa overlap. Contains Pfam match to entry PF00401 ATP-synt_DE, ATP synthase, Delta/Epsilon chain. P45822 No intermediary metabolism and respiration PF00401,PF02823 P45822 GO:0046933,GO:0005886,GO:0042777,GO:0045261,GO:0046961,GO:0005524 Rv1311 Rv1311 AL450380.2 Mycobrowser_v4 CDS 1718073 1718622 . - 0 ML1432c pncA Pyrazinamidase/nicotinamidase PncA (pseudogene) ML1432c, len: 550 bp. Possible pseudogene of M. tuberculosis orthologue pncA|Rv2043c (561 bp) (Best blastx scores: 195). Yes intermediary metabolism and respiration Rv2043c Rv2043c AL450380.2 Mycobrowser_v4 CDS 1753337 1753870 . + 0 ML1459 ML1459 Conserved hypothetical protein (pseudogene) ML1459, len: 534 bp. Possible pseudogene similar to M. tuberculosis Rv0791c (1044 bp) (Best blastx scores: 114). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1753886 1755874 . - 0 ML1460c ML1460c Probable cyclase (adenylyl- or guanylyl-cyclase) (pseudogene) ML1460c, len: 1989 bp. Possible pseudogene of M. tuberculosis orthologue Rv2435c (2193 bp) (Best blastx scores: 545). Yes intermediary metabolism and respiration Rv2435c Rv2435c AL450380.2 Mycobrowser_v4 CDS 2629352 2629934 . + 0 ML2212 ML2212 Conserved hypothetical protein (pseudogene) ML2212, len: 583 bp. Possible pseudogene of M. tuberculosis orthologue Rv0802c (657 bp) (Best blastx scores: 180). Yes intermediary metabolism and respiration Rv0802c Rv0802c AL450380.2 Mycobrowser_v4 CDS 2674581 2675349 . - 0 ML2251c ML2251c Possible enoyl-CoA hydratase (pseudogene) ML2251c, len: 769 bp. Possible pseudogene similar to M. tuberculosis echA13|Rv1935c (957 bp) (Best blastx scores: 169). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1758795 1759161 . + 0 ML1462 ML1462 Conserved hypothetical protein (pseudogene) ML1462, len: 367 bp. Possible pseudogene of M. tuberculosis orthologue Rv2437 (420 bp) (Best blastx scores: 173). Yes cell wall and cell processes Rv2437 Rv2437 AL450380.2 Mycobrowser_v4 CDS 1794949 1796947 . + 0 ML1490 fadH Probable NADPH-dependent 2,4-Dienoyl-CoA reductase FadH (pseudogene) ML1490, len: 1999 bp. Possible pseudogene of M. tuberculosis orthologue fadH|Rv1175c (2025 bp) (Best blastx scores: 466). Yes lipid metabolism Rv1175c Rv1175c AL450380.2 Mycobrowser_v4 CDS 2678870 2679429 . + 0 ML2255 ML2255 Hypothetical protein (pseudogene) ML2255, len: 560 bp. Possible pseudogene of M. tuberculosis orthologue Rv3491 (579 bp) (Best blastx scores: 304). Yes conserved hypotheticals Rv3491 Rv3491 AL450380.2 Mycobrowser_v4 CDS 1636181 1636916 . + 0 ML1375 ML1375 Probable transcriptional regulator (IclR family) (pseudogene) ML1375, len: 736 bp. Possible pseudogene of M. tuberculosis orthologue Rv1719 (780 bp) (Best blastx scores: 433). Yes regulatory proteins Rv1719 Rv1719 AL450380.2 Mycobrowser_v4 CDS 1639504 1641271 . + 0 ML1376 ML1376 Possible transferase (pseudogene) ML1376, len: 1768 bp. Possible pseudogene similar to M. tuberculosis Rv3225c (1425 bp) (Best blastx scores: 314). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2109665 2110134 . + 0 ML1747 ligB Probable ATP-dependent DNA ligase LigB (pseudogene) ML1747, len: 470 bp. Possible pseudogene of M. tuberculosis orthologue ligB|Rv3062 (1524 bp) (Best blastx scores: 120). Yes information pathways Rv3062 Rv3062 AL450380.2 Mycobrowser_v4 CDS 986477 987766 . + 0 ML0831 dgt PROBABLE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DGT (DGTPASE) (DGTP TRIPHOSPHOHYDROLASE) ML0831, len: 429 aa. Probable dgt, deoxyguanosine triphosphate triphosphohydrolase (EC 3.1.5.1). Similar to Rv2344c|MTCY98.13c|DGTP_MYCTU|P95240 Mycobacterium tuberculosis deoxyguanosinetriphosphate triphosphohydrolase dgt(431 aa) fasta scores: E(): 0, 83.8% identity in 421 aa and to many hypothetical deoxyguanosine hydrolases. Contains Pfam match to entry PF01966 HD, HD domain. BELONGS TO THE DGTPASE FAMILY. Q9CCG3 No intermediary metabolism and respiration PF01966 Q9CCG3 GO:0008832,GO:0000287,GO:0046039 Rv2344c Rv2344c AL450380.2 Mycobrowser_v4 CDS 2675774 2676010 . - 0 ML2252c ML2252c hypothetical protein ML2252c, len: 78 aa. Hypothetical unknown protein. Q7APX0 No unknown Q7APX0 AL450380.2 Mycobrowser_v4 CDS 1221790 1222077 . + 0 ML1056 esxL1 Putative ESAT-6 like protein EsxL1 (ESAT-6 LIKE PROTEIN 4) ML1056, len: 95 aa. Probable esxL1, ESAT-6 like protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein Q49946|U15180 (95 aa), Fasta scores: E(): 0, (100.0% identity in 95 aa overlap). Also similar to several putative Esat-6 like proteins from M. tuberculosis e.g. O05300|ESXL_MYCTU ESAT-6 like protein esxL (94 aa), fasta scores: E(): 4.6e-24, (64.130% identity in 92 aa overlap). Identical to ML1180c a possible paralogue of M. tuberculosis esxL2. SEEMS TO BELONG TO THE ESAT6 FAMILY. Q49946 No cell wall and cell processes Q49946 Rv1198 Rv1198 AL450380.2 Mycobrowser_v4 CDS 1940969 1941392 . - 0 ML1619c ML1619c Conserved hypothetical protein (pseudogene) ML1619c, len: 424 bp. Possible pseudogene of M. tuberculosis orthologue Rv2910c (444 bp) (Best blastx scores: 158). Yes conserved hypotheticals Rv2910c Rv2910c AL450380.2 Mycobrowser_v4 CDS 1797213 1797468 . + 0 ML1491 ML1491 Low molecular weight T-cell antigen TB8.4 homolog (pseudogene) ML1491, len: 256 bp. Possible pseudogene of M. tuberculosis orthologue Rv1174c|TB8.4 (333 bp) (Best blastx scores: 115). Yes cell wall and cell processes Rv1174c Rv1174c AL450380.2 Mycobrowser_v4 CDS 1802958 1803563 . + 0 ML1496 ML1496 Probable transcriptional regulatory protein (pseudogene) ML1496, len: 606 bp. Possible pseudogene of M. tuberculosis orthologue Rv1167c (606 bp) (Best blastx scores: 300). Yes regulatory proteins Rv1167c Rv1167c AL450380.2 Mycobrowser_v4 CDS 1941439 1942675 . - 0 ML1620c pknI Probable transmembrane serine-threonine protein kinase I PknI (pseudogene) ML1620c, len: 1237 bp. Possible pseudogene of M. tuberculosis orthologue pknI|Rv2914c (1758 bp) (Best blastx scores: 190). Yes regulatory proteins Rv2914c Rv2914c AL450380.2 Mycobrowser_v4 CDS 1094379 1095815 . + 0 ML0925 glnA GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (Glutamate--ammonia ligase 1) (GS-I) ML0925, len: 478 aa. Probable glnA, glutamine synthase class I (EC 6.3.1.2). Highly similar to many glutamine synthetases (EC 6.3.1.2) including examples from: Mycobacterium tuberculosis Rv2220 SW:GLN1_MYCTU (Q10377) (478 aa), Fasta scores: E(): 0, (91.8% identity in 478 aa overlap) and Salmonella typhimurium SW:GLNA_SALTY (P06201) (468 aa), Fasta scores: E(): 0, (51.5% identity in 474 aa overlap). Also similar to ML1631 from M. leprae. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Contains PS00182 Glutamine synthetase class-I adenylation site. Contains PS00180 Glutamine synthetase signature 1. Contains PS00181 Glutamine synthetase putative ATP-binding region signature. Belongs to the glutamine synthetase family. Q9CCD8 No intermediary metabolism and respiration PF00120,PF03951 Q9CCD8 GO:0004356,GO:0006542,GO:0009399,GO:0005737 6.3.1.2 Rv2220 Rv2220 AL450380.2 Mycobrowser_v4 CDS 1942747 1943812 . - 0 ML1621c ML1621c Conserved hypothetical protein (pseudogene) ML1621c, len: 1066 bp. Possible pseudogene of M. tuberculosis orthologue Rv2915c (1113 bp) (Best blastx scores: 434). Yes conserved hypotheticals Rv2915c Rv2915c AL450380.2 Mycobrowser_v4 CDS 1507580 1508365 . + 0 ML1263 hisF histidine biosynthesis pathway (fifth step). IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit [CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O]. Imidazole glycerol phosphate synthase subunit HisF (IGP synthase cyclase subunit) (IGP synthase subunit hisF) (ImGP synthase subunit hisF) ML1263, len: 261 aa. Probable hisF, Imidazole glycerol phosphate synthase subunity. Highly similar to many cyclases involved in histidine biosynthesis including: Mycobacterium tuberculosis Rv1605 SW:HIS6_MYCTU (O53908) (267 aa), Fasta scores: E(): 0, 89.8% identity in 256 aa overlap and Bacillus subtilis SW:HIS6_BACSU (O34727) (252 aa), Fasta scores: E(): 0, 53.0% identity in 253 aa overlap. Contains Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein. Belongs to the hisA / hisF family. Q9X7C2 No intermediary metabolism and respiration PF00977 Q9X7C2 GO:0000105,GO:0000107,GO:0016829,GO:0005737 4.1.3.- Rv1605 Rv1605 AL450380.2 Mycobrowser_v4 CDS 2003274 2003854 . + 0 ML1662 ML1662 Probable integral membrane protein (pseudogene) ML1662, len: 581 bp. Possible pseudogene of M. tuberculosis orthologue Rv2963 (Best blastx scores: 136). Yes cell wall and cell processes Rv2963 Rv2963 AL450380.2 Mycobrowser_v4 CDS 1687137 1687463 . - 0 ML1405c ML1405c transposase (pseudogene) ML1405c, len: 327 bp. Possible pseudogene similar to many transposases e.g. Q53053 from Rhodococcus, Q48344 (carried on IS6120) from Mycobacterium smegmatis and Q9ZA68 (carried on IS666) from Mycobacterium avium. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1517444 1518436 . + 0 ML1274 lgt Possible prolipoprotein diacylglyceryl transferases Lgt ML1274, len: 330 aa. Possible lgt, prolipoprotein diacylglyceryl transferase (EC 2.4.99.-). Similar to many prolipoprotein diacylglyceryl transferases constituting the first step in lipoprotein biosynthesis e.g. Staphylococcus aureus SW:LGT_STAAU (P52282) (279 aa), Fasta scores: E(): 3.3e-12, 30.6% identity in 258 aa overlap and Mycobacterium tuberculosis Rv1614 TR:O06131 (EMBL:Z95554) (468 aa), Fasta scores: E(): 0, 75.5% identity in 322 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01790 LGT, Prolipoprotein diacylglyceryl transferase. Q9CC52 No cell wall and cell processes PF01790 Q9CC52 GO:0042158,GO:0008961,GO:0005886,GO:0009249,GO:0016021 2.4.99.- Rv1614 Rv1614 AL450380.2 Mycobrowser_v4 CDS 1736403 1738010 . - 0 ML1442c ML1442c Conserved hypothetical protein (pseudogene) ML1442c, len: 1608 bp. Possible pseudogene of M. tuberculosis orthologue Rv2052c (1605 bp) (Best blastx scores: 832). Yes conserved hypotheticals Rv2052c Rv2052c AL450380.2 Mycobrowser_v4 CDS 1719468 1719678 . - 0 ML1433c ML1433c Conserved hypothetical protein (pseudogene) ML1433c, len: 211 bp. Possible pseudogene of M. tuberculosis orthologue Rv2044c (318 bp) (Best blastx scores: 110). Yes conserved hypotheticals Rv2044c Rv2044c AL450380.2 Mycobrowser_v4 CDS 958885 960108 . - 0 ML0810c ML0810c Possible secreted protein ML0810c, len: 407 aa. Possible secreted protein. Similar to O05854|Z9512|Rv3212|MTCY07D11.14c Mycobacterium tuberculosis hypothetical 42.5 kDa protein (407 aa), fasta scores: E(): 0, 79.9% identity in 407 aa. Contains N-terminal hydrophobic region. Q9CCH4 No cell wall and cell processes, conserved hypotheticals Q9CCH4 Rv3212 Rv3212 AL450380.2 Mycobrowser_v4 CDS 1706395 1706748 . + 0 ML1420 ML1420 hypothetical protein ML1420, len: 117 aa. Hypothetical unknown protein. Q7AQ56 No unknown Q7AQ56 AL450380.2 Mycobrowser_v4 CDS 1056244 1057491 . + 0 ML0890 ML0890 CONSERVED HYPOTHETICAL PROTEIN ML0890, len: 415 aa. Conserved hypothetical protein. Highly similar, to Mycobacterium tuberculosis hypothetical protein TR:O53518 (EMBL:AL021957) (379 aa), Fasta scores: E(): 0, 79.4% identity in 378 aa overlap and weakly similar to many anion-transporting ATPases e.g. SW:ARA2_ECOLI (SW:P52145) (583 aa), Fasta scores: E(): 5.2e-07, 29.6% identity in 314 aa overlap. Previously sequenced as Mycobacterium leprae hypothetical protein TR:O69574 (EMBL:AL022602) (415 aa), Fasta scores: E(): 0, 99.8% identity in 415 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7AQD9 No conserved hypotheticals PF02374 Q7AQD9 GO:0006875,GO:0005524 Rv2184c Rv2184c AL450380.2 Mycobrowser_v4 CDS 1748923 1749217 . + 0 ML1455 ML1455 Hypothetical protein (pseudogene) ML1455, len: 295 bp. Possible pseudogene of M. tuberculosis orthologue Rv2422 (273 bp) (Best blastx scores: 96). Yes conserved hypotheticals Rv2422 Rv2422 AL450380.2 Mycobrowser_v4 CDS 2248201 2248719 . - 0 ML1868c ML1868c Conserved hypothetical protein (pseudogene) ML1868c, len: 519 bp. Possible pseudogene of M. tuberculosis orthologue Rv0695 (756 bp) (Best blastx scores: 251). Yes conserved hypotheticals Rv0695 Rv0695 AL450380.2 Mycobrowser_v4 CDS 1295914 1298535 . + 0 ML1120 ML1120 conserved hypothetical protein ML1120, len: 873 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1278 SW:YC78_MYCTU (Q11042) (875 aa), Fasta scores: E(): 0, 69.5% identity in 872 aa overlap. Contains multiple possible coiled-coils. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CC83 No conserved hypotheticals Q9CC83 Rv1278 Rv1278 AL450380.2 Mycobrowser_v4 CDS 1445950 1446669 . - 0 ML1224c ML1224c conserved hypothetical protein ML1224c, len: 239 aa. Conserved hypothetical protein. Previously sequenced Mycobacterium leprae hypothetical protein TR:Q49628 (EMBL:U00010) (286 aa), Fasta scores: E(): 0, 100.0% identity in 233 aa overlap. Also highly similar toseveral other proteins of unproven function including: Mycobacterium tuberculosis hypothetical protein Rv1593c TR:O06597 (EMBL:Z95586) (236 aa), Fasta scores: E(): 0, 85.7% identity in 238 aa overlap and Streptomyces coelicolor TR:Q9S233 (EMBL:AL109848) (239 aa), Fasta scores: E(): 1.1e-19, 38.2% identity in 191 aa overlap putative DNA hydrolase. Q9CC66 No conserved hypotheticals PF00293 Q9CC66 GO:0016787 Rv1593c Rv1593c AL450380.2 Mycobrowser_v4 CDS 1577745 1578182 . + 0 ML1325 ML1325 Conserved hypothetical protein (pseudogene) ML1325, len: 438 bp. Possible pseudogene of M. tuberculosis orthologue Rv2103c (435 bp) (Best blastx scores: 404). Yes virulence, detoxification, adaptation Rv2103c Rv2103c AL450380.2 Mycobrowser_v4 CDS 2216058 2216875 . - 0 ML1830c ML1830c Probable histidinol-phosphate aminotransferase (pseudogene) ML1830c, len: 818 bp. Possible pseudogene similar to M. tuberculosis hisC2|Rv3772 (1062 bp) (Best blastx scores: 129) and other histidinol-phosphate aminotransferases. Also similar to ML0122c a possible pseudogene similar to M. tuberculosis hisC2. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1077593 1079146 . + 0 ML0910 murF ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF ML0910, len: 517 aa. Probable murF, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase (EC 6.3.2.15). Identical to the previously sequenced Mycobacterium leprae hypothetical protein UDP-N-acetylmuramoylalanyl-D-glutamyl -2,6-diaminopimelate--D-alanyl-D-alanyl ligase TR:O69556 (EMBL:AL022602) (517 aa), Fasta scores: E(): 0, 100.0% identity in 517 aa overlap. Also highly similar to MurF orthologues from Mycobacterium tuberculosis Rv2157c SW:MURF_MYCTU (SW:O06220) (510 aa), Fasta scores: E(): 0, 75.5% identity in 531 aa overlap and Escherichia coli SW:MURF_ECOLI (SW:P11880) (452 aa), Fasta scores: E(): 1.7e-09, 31.0% identity in 519 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. O69556 No cell wall and cell processes PF01225,PF02875,PF08245 O69556 GO:0047480,GO:0008766,GO:0007049,GO:0051301,GO:0007047,GO:0005737,GO:0009252,GO:0008360,GO:0005524 6.3.2.10 Rv2157c Rv2157c AL450380.2 Mycobrowser_v4 CDS 1774190 1775245 . - 0 ML1473c ML1473c Conserved hypothetical protein (pseudogene) ML1473c, len: 1056 bp. Possible pseudogene of M. tuberculosis orthologue Rv2449c (1260 bp) (Best blastx scores: 203). Yes conserved hypotheticals Rv2449c Rv2449c AL450380.2 Mycobrowser_v4 CDS 1567074 1567367 . - 0 ML1314c ML1314c conserved hypothetical protein ML1314c, len: 97 aa. Conserved hypothetical protein. Highly similar to several proteins of unknown function e.g. Mycobacterium tuberculosis Rv2117 TR:O33252 (EMBL:Z97559) (97 aa), Fasta scores: E(): 0, 85.6% identity in 97 aa overlap. Q7AQ70 No conserved hypotheticals PF04456 Q7AQ70 Rv2117 Rv2117 AL450380.2 Mycobrowser_v4 CDS 1757789 1758499 . + 0 ML1461 rbsK Ribokinase RbsK (pseudogene) ML1461, len: 711 bp. Possible pseudogene of M. tuberculosis orthologue rbsK|Rv2436 (915 bp) (Best blastx scores: 102). Yes intermediary metabolism and respiration Rv2436 Rv2436 AL450380.2 Mycobrowser_v4 CDS 1697094 1697815 . + 0 ML1415 pks10 Possible chalcone synthase Pks10 (pseudogene) ML1415, len: 722 bp. Possible pseudogene of M. tuberculosis orthologue pks10|Rv1660 (1062 bp) (Best blastx scores: 265). Yes lipid metabolism Rv1660 Rv1660 AL450380.2 Mycobrowser_v4 CDS 1697969 1699251 . + 0 ML1416 pks7 Probable polyketide synthase Pks7 (pseudogene) ML1416, len: 1283 bp. Possible pseudogene of M. tuberculosis orthologue pks7|Rv1661 (6381 bp) (Best blastx scores: 371). Yes lipid metabolism Rv1661 Rv1661 AL450380.2 Mycobrowser_v4 CDS 1810607 1814267 . - 0 ML1502c narG Probable respiratory nitrate reductase (alpha chain) NarG (pseudogene) ML1502c, len: 3661 bp. Possible pseudogene of M. tuberculosis orthologue narG|Rv1161 (3699 bp) (Best blastx scores: 864). Yes intermediary metabolism and respiration Rv1161 Rv1161 AL450380.2 Mycobrowser_v4 CDS 1837226 1837627 . - 0 ML1522c ML1522c Probable short-chain dehydrogenase/reductase (pseudogene) ML1522c, len: 402 bp. Possible pseudogene of M. tuberculosis orthologue Rv2766c (783 bp) (Best blastx scores: 209). Yes intermediary metabolism and respiration Rv2766c Rv2766c AL450380.2 Mycobrowser_v4 CDS 1551423 1552168 . + 0 ML1303 ML1303 Probable oxidoreductase (pseudogene) ML1303, len: 746 bp. Possible pseudogene of M. tuberculosis orthologue Rv2129c (882 bp) (Best blastx scores: 193). Yes intermediary metabolism and respiration Rv2129c Rv2129c AL450380.2 Mycobrowser_v4 CDS 1609370 1609928 . - 0 ML1348c ML1348c Conserved hypothetical protein (pseudogene) ML1348c, len: 559 bp. Possible pseudogene of M. tuberculosis orthologue Rv1685c (624 bp) (Best blastx scores: 335). Yes conserved hypotheticals Rv1685c Rv1685c AL450380.2 Mycobrowser_v4 CDS 1577421 1577659 . + 0 ML1324 ML1324 Conserved hypothetical protein (pseudogene) ML1324, len: 239 bp. Possible pseudogene of M. tuberculosis orthologue Rv2104c (255 bp) (Best blastx scores: 174). Yes virulence, detoxification, adaptation Rv2104c Rv2104c AL450380.2 Mycobrowser_v4 CDS 1617920 1618105 . + 0 ML1357 ML1357 conserved hypothetical protein ML1357, len: 61 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis Rv1693 TR:O33195 (EMBL:Z98268) (58 aa), Fasta scores: E(): 9.7e-13, 73.8% identity in 61 aa overlap. Q9CC31 No conserved hypotheticals Q9CC31 Rv1693 Rv1693 AL450380.2 Mycobrowser_v4 CDS 1609118 1609351 . + 0 ML1347 ML1347 conserved hypothetical protein ML1347, len: 77 aa. Conserved hypothetical protein. Highly similar to proteins of unknown function from Mycobacterium tuberculosis Rv1684 TR:O33186 (EMBL:Z98268) (74 aa), Fasta scores: E(): 6.9e-20, 70.1% identity in 77 aa overlap and Streptomyces coelicolor TR:CAB88911 (EMBL:AL353862) (56 aa), Fasta scores: E(): 0.0064, 48.2% identity in 56 aa overlap. Q9CC33 No conserved hypotheticals PF03966 Q9CC33 Rv1684 Rv1684 AL450380.2 Mycobrowser_v4 CDS 1540168 1540330 . - 0 ML1291c ML1291c Probable transposase (pseudogene) ML1291c, len: 163 bp. Possible pseudogene similar to several M. tuberculosis transposases associated with IS6110 (Best blastx scores: 75) and identical to ML1820A, ML0599A, ML1820A, ML0568B from M. leprae. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1544613 1545659 . - 0 ML1295c lppL Probable conserved lipoprotein LppL (pseudogene) ML1295c, len: 1047 bp. Possible pseudogene similar to M. tuberculosis orthologue lppL|Rv2138 (1077 bp) (Best blast scores: 1243). Yes cell wall and cell processes Rv2138 Rv2138 AL450380.2 Mycobrowser_v4 CDS 1563417 1563705 . + 0 ML1311 ML1311 Probable conserved integral membrane protein (pseudogene) ML1311, len: 289 bp. Possible pseudogene of M. tuberculosis orthologue Rv2120c (483 bp) (Best blastx scores: 151). Yes cell wall and cell processes Rv2120c Rv2120c AL450380.2 Mycobrowser_v4 CDS 1570099 1570395 . - 0 ML1317c ML1317c Hypothetical protein (pseudogene) ML1317c, len: 297 bp. Possible pseudogene of M. tuberculosis orthologue Rv2114 (624 bp) (Best blastx scores: 169). Yes conserved hypotheticals Rv2114 Rv2114 AL450380.2 Mycobrowser_v4 CDS 1588162 1589095 . - 0 ML1335c ML1335c Probable 5'-3' exonuclease (pseudogene) ML1335c, len: 934 bp. Possible pseudogene of M. tuberculosis orthologue Rv2090 (1182 bp) (Best blastx scores: 363). Yes information pathways Rv2090 Rv2090 AL450380.2 Mycobrowser_v4 CDS 1631209 1631880 . + 0 ML1371 cmk Probable Cytidylate kinase Cmk (CMP kinase) (Cytidine monophosphate kinase) (CK) ML1371, len: 223 aa. Probable cmk, Cytidylate kinase (EC 2.7.4.14). Highly similar to several cytidylate kinases including: Bacillus subtilis SW:KCY_BACSU (P38493) (224 aa), Fasta scores: E(): 1.9e-28, 42.7% identity in 218 aa overlap and Mycobacterium tuberculosis Rv1712 TR:O33211 (EMBL:Z98268) (230 aa), Fasta scores: E(): 0, 74.8% identity in 222 aa overlap. Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q49885 No intermediary metabolism and respiration PF02224 Q49885 GO:0004127,GO:0005737,GO:0006220,GO:0005524 2.7.4.14 Rv1712 Rv1712 AL450380.2 Mycobrowser_v4 CDS 1538218 1539644 . + 0 ML1290 ML1290 Conserved 13E12 repeat family protein (pseudogene) ML1290, len: 1427 bp. Possible pseudogene similar to M. tuberculosis 13E12 repeat family e.g. Rv0336 or Rv0515 (Best blastx scores: 367), also similar to M. leprae ML1850 pseudogene. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1578225 1578728 . - 0 ML1326c ML1326c Conserved hypothetical protein (pseudogene) ML1326c, len: 504 bp. Possible pseudogene of M. tuberculosis orthologue Rv2102 (717 bp) (Best blastx scores: 126). Yes conserved hypotheticals Rv2102 Rv2102 AL450380.2 Mycobrowser_v4 CDS 1578934 1579641 . - 0 ML1327c ML1327c Conserved hypothetical protein (pseudogene) ML1327c, len: 708 bp. Possible pseudogene of M. tuberculosis orthologue Rv2100 (1653 bp), member of M. tuberculosis REP13E12 repeat family (Best blastx scores: 212). Yes insertion seqs and phages Rv2100 Rv2100 AL450380.2 Mycobrowser_v4 CDS 2248752 2249883 . - 0 ML1869c lldD1 Possible L-lactate dehydrogenase (cytochrome) LldD1 (pseudogene) ML1869c, len: 1132 bp. Possible pseudogene of M. tuberculosis orthologue lldD1|Rv0694 (1191 bp) (Best blastx scores: 506). Yes intermediary metabolism and respiration Rv0694 Rv0694 AL450380.2 Mycobrowser_v4 CDS 1540616 1540858 . - 0 ML1292c ML1292c conserved hypothetical protein ML1292c, len: 80 aa. Conserved hypothetical protein, identical to the other hypothetical CDS ML0568A and ML0599B from M. leprae. Q7AQ76 No conserved hypotheticals Q7AQ76 AL450380.2 Mycobrowser_v4 CDS 1544359 1544613 . - 0 ML1294c ML1294c conserved hypothetical protein ML1294c, len: 84 aa. Conserved hypothetical protein, similar to Q9AD94 Hypothetical protein SCO1673 from Streptomyces coelicolor (62 aa), fasta scores: E(): 0.00042, (44.000% identity in 50 aa overlap). Q9CC44 No conserved hypotheticals Q9CC44 AL450380.2 Mycobrowser_v4 CDS 1545744 1546079 . + 0 ML1296 ML1296 conserved hypothetical protein ML1296, len: 111 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv2137c TR:O06238 (EMBL:Z95388) (137 aa), Fasta scores: E(): 1.3e-28, 75.5% identity in 106 aa overlap. Q9CC43 No conserved hypotheticals Q9CC43 Rv2137c Rv2137c AL450380.2 Mycobrowser_v4 CDS 1547795 1548385 . + 0 ML1299 ML1299 conserved hypothetical protein ML1299, len: 196 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2134c TR:O06241 (EMBL:Z95388) (195 aa), Fasta scores: E(): 0, 91.1% identity in 192 aa overlap. Q7AQ75 No conserved hypotheticals Q7AQ75 Rv2134c Rv2134c AL450380.2 Mycobrowser_v4 CDS 1548396 1549184 . + 0 ML1300 ML1300 conserved hypothetical protein ML1300, len: 262 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2133c TR:O06242 (EMBL:Z95388) (262 aa), Fasta scores: E(): 0, 79.4% identity in 262 aa overlap. Q9CC40 No conserved hypotheticals PF00454 Q9CC40 GO:0016773 Rv2133c Rv2133c AL450380.2 Mycobrowser_v4 CDS 1570553 1571558 . - 0 ML1318c ML1318c Probable integral membrane protein (pseudogene) ML1318c, len: 1006 bp. Possible pseudogene of M. tuberculosis orthologue Rv2113 (1194 bp) (Best blastx scores: 211). Yes cell wall and cell processes Rv2113 Rv2113 AL450380.2 Mycobrowser_v4 CDS 1565157 1566041 . - 0 ML1312c ML1312c conserved hypothetical protein ML1312c, len: 294 aa. Conserved hypothetical protein. Highly similar to several proteins of unknown function e.g. Mycobacterium tuberculosis Rv2119 TR:O33254 (EMBL:Z97559) (278 aa), Fasta scores: E(): 0, 79.9% identity in 278 aa overlap. Q7AQ72 No conserved hypotheticals Q7AQ72 Rv2119 Rv2119 AL450380.2 Mycobrowser_v4 CDS 1733351 1733686 . + 0 ML1439 ML1439 conserved hypothetical protein ML1439, len: 111 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2050 TR:O53492 (EMBL:AL021899) (111 aa), Fasta scores: E(): 0, 97.3% identity in 111 aa overlap. Q9CC05 No conserved hypotheticals Q9CC05 Rv2050 Rv2050 AL450380.2 Mycobrowser_v4 CDS 2012870 2013061 . + 0 ML1668B ML1668B Conserved hypothetical protein ML1668B, len: 63 aa. Conserved hypothetical protein. Highly similar to the N-terminal region of Rv2970a Conserved hypothetical protein (56 aa), fasta scores: E(): 8.2e-11, (68.421% identity in 38 aa overlap) and Mb2995 from M. bovis (56 aa). No conserved hypotheticals AL450380.2 Mycobrowser_v4 CDS 1645074 1645637 . + 0 ML1380 ML1380 conserved hypothetical protein ML1380, len: 187 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1780 TR:O53931 (EMBL:AL022021) (187 aa), Fasta scores: E(): 0, 82.4% identity in 187 aa overlap. Q7AQ58 No conserved hypotheticals Q7AQ58 Rv1780 Rv1780 AL450380.2 Mycobrowser_v4 CDS 1561970 1562251 . + 0 ML1309 hisE Probable phosphoribosyl-AMP pyrophosphatase HisE ML1309, len: 93 aa. Probable phosphoribosyl-AMP pyrophosphatase (EC 3.6.1.31). Highly similar to several phosphoribosyl-ATP pyrophosphatases involved in histidine biosynthesis, including: Sulfolobus solfataricus HisE SW:HIS2_SULSO (O33776) (94 aa), Fasta scores: E(): 0.00013, 32.5% identity in 83 aa overlap and Mycobacterium tuberculosis Rv2122c|HIS2_MYCTU (O33257) (93 aa), Fasta scores: E(): 2.5e-31, 86.0% identity in 93 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase. Q49786 No intermediary metabolism and respiration PF01503 Q49786 GO:0005737,GO:0000105,GO:0004636,GO:0005524 3.6.1.31 Rv2122c Rv2122c AL450380.2 Mycobrowser_v4 CDS 1589276 1590275 . + 0 ML1336 pepE Probable dipeptidase PepE (pseudogene) ML1336, len: 1000 bp. Possible pseudogene of M. tuberculosis orthologue pepE|Rv2089c (1128 bp) (Best blastx scores: 243). Yes intermediary metabolism and respiration Rv2089c Rv2089c AL450380.2 Mycobrowser_v4 CDS 1595006 1595367 . - 0 ML1337c ML1337c Conserved hypothetical protein (pseudogene) ML1337c, len: 362 bp. Possible pseudogene of M. tuberculosis orthologue Rv2674 (411 bp) (Best blastx scores: 159). Yes intermediary metabolism and respiration Rv2674 Rv2674 AL450380.2 Mycobrowser_v4 CDS 1738026 1738485 . - 0 ML1443c ML1443c Probable transmembrane protein (pseudogene) ML1443c, len: 460 bp. Possible pseudogene of M. tuberculosis orthologue Rv2053c (528 bp) (Best blastx scores: 166). Yes cell wall and cell processes Rv2053c Rv2053c AL450380.2 Mycobrowser_v4 CDS 1848860 1850743 . - 0 ML1533c PPE PPE-family protein (pseudogene) ML1533c, len: 1883 bp. Possible pseudogene of M. tuberculosis orthologue PPE31|Rv1807 (1200 bp) (Best blastx scores: 229). Yes PE/PPE Rv1807 Rv1807 AL450380.2 Mycobrowser_v4 CDS 1599258 1600329 . + 0 ML1341 ML1341 Conserved hypothetical protein (pseudogene) ML1341, len: 1072 bp. Possible pseudogene of M. tuberculosis orthologue Rv2670c (1110 bp) (Best blastx scores: 1011). Yes conserved hypotheticals Rv2670c Rv2670c AL450380.2 Mycobrowser_v4 CDS 1600322 1600505 . - 0 ML1342c ML1342c Conserved hypothetical protein (pseudogene) ML1342c, len: 184 bp. Possible pseudogene of M. tuberculosis orthologue Rv2669 (471 bp) (Best blastx scores: 87). Yes intermediary metabolism and respiration Rv2669 Rv2669 AL450380.2 Mycobrowser_v4 CDS 1600581 1600662 . - 0 ML1343c ML1343c Possible exported alanine and valine rich protein (pseudogene) ML1343c, len: 82 bp. Possible pseudogene of M. tuberculosis orthologue Rv2668 (522 bp) (Best blastx scores: 131). Yes cell wall and cell processes Rv2668 Rv2668 AL450380.2 Mycobrowser_v4 CDS 1604188 1605805 . + 0 ML1345 ML1345 Probable transcriptional regulatory protein (LuxR family) (pseudogene) ML1345, len: 1618 bp. Possible pseudogene similar to several M. tuberculosis transcriptional regulators e.g. Rv0890c and Rv1358 (Best blastx scores: 327). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1576557 1577354 . + 0 ML1323 prcA probable proteasome (alpha subunit) PrcA ML1323, len: 265 aa. Probable prcA, proteasome (alpha subunit 0 (EC 3.4.25.1). Highly similar to many proposed 20S proteasome alpha subunits including: Rhodococcus sp. TR:Q53080 (EMBL:U26421) (259 aa), Fasta scores: E(): 0, 65.5% identity in 255 aa overlap and Mycobacterium tuberculosis Rv2109c TR:O33244 (EMBL:Z97559) (248 aa), Fasta scores: E(): 0, 91.8% identity in 244 aa overlap. Q9S375 No intermediary metabolism and respiration PF00227 Q9S375 GO:0005839,GO:0004298,GO:0006511,GO:0005829 Rv2109c Rv2109c AL450380.2 Mycobrowser_v4 CDS 1587326 1588144 . + 0 ML1334 ML1334 possible conserved membrane protein ML1334, len: 272 aa. Possible conserved membrane protein. Highly similar to several e.g. Mycobacterium tuberculosis hypothetical protein Rv2091c SW:YK91_MYCTU (Q10700) (244 aa), Fasta scores: E(): 0, 62.9% identity in 272 aa overlap. Note the product of this CDS contains a 7xPGQYG(P/S) repeat region similar to several bacterial protein calcium binding domains. Contains a possible membrane spanning hydrophobic domain. Q7AQ65 No cell wall and cell processes PF01391 Q7AQ65 Rv2091c Rv2091c AL450380.2 Mycobrowser_v4 CDS 1613461 1614911 . - 0 ML1353c ML1353c Conserved hypothetical protein (pseudogene) ML1353c, len: 1451 bp. Possible pseudogene of M. tuberculosis orthologue Rv1376 (1494 bp) (Best blastx scores: 348). Yes conserved hypotheticals Rv1376 Rv1376 AL450380.2 Mycobrowser_v4 CDS 1615067 1615299 . - 0 ML1354c ML1354c Conserved hypothetical protein (pseudogene) ML1354c, len: 233 bp. Possible pseudogene of M. tuberculosis orthologue Rv1375 (1320 bp) (Best blastx scores: 110). Yes conserved hypotheticals Rv1375 Rv1375 AL450380.2 Mycobrowser_v4 CDS 1616275 1616817 . + 0 ML1355 ML1355 Conserved hypothetical protein (pseudogene) ML1355, len: 543 bp. Possible pseudogene of M. tuberculosis orthologue Rv1691 (753 bp) (Best blastx scores: 306). Yes conserved hypotheticals Rv1691 Rv1691 AL450380.2 Mycobrowser_v4 CDS 1616893 1617920 . + 0 ML1356 ML1356 Probable phosphatase (pseudogene) ML1356, len: 1028 bp. Possible pseudogene of M. tuberculosis orthologue Rv1692 (1062 bp) (Best blastx scores: 433). Yes intermediary metabolism and respiration Rv1692 Rv1692 AL450380.2 Mycobrowser_v4 CDS 1740515 1740793 . - 0 ML1447c cobN Probable cobalamin biosynthesis protein CobN (pseudogene) ML1447c, len: 279 bp. Possible pseudogene of M. tuberculosis orthologue cobN|Rv2062c (3585 bp) (Best blastx scores: 284). Yes intermediary metabolism and respiration Rv2062c Rv2062c AL450380.2 Mycobrowser_v4 CDS 1625921 1626533 . + 0 ML1364 ML1364 Nudix hydrolase (pseudogene) ML1364, len: 613 bp. Possible pseudogene of M. tuberculosis orthologue Rv1700 (624 bp) (Best blastx scores: 554). Yes information pathways Rv1700 Rv1700 AL450380.2 Mycobrowser_v4 CDS 1602986 1603246 . - 0 ML1344c ML1344c Hypothetical unknown protein ML1344c, len: 86 aa. Hypothetical unknown protein (doubtful CDS). Q9CC35 No unknown Q9CC35 AL450380.2 Mycobrowser_v4 CDS 2211844 2212480 . - 0 ML1827c cobQ1 Probable cobyric acid synthase CobQ1 (pseudogene) ML1827c, len: 637 bp. Possible pseudogene of M. tuberculosis orthologue cobQ1|Rv0255c (Best blastx scores: 336). Yes intermediary metabolism and respiration Rv0255c Rv0255c AL450380.2 Mycobrowser_v4 CDS 1596795 1598372 . - 0 ML1339c ML1339c POSSIBLE SECRETED PROTEASE ML1339c, len: 525 aa. Possible secreted protease. Highly similar to several proteases including: Streptomyces lividans TR:Q54399 (EMBL:L42759) (513 aa), Fasta scores: E(): 2.7e-19, 25.7% identity in 548 aa overlap and Mycobacterium tuberculosis Rv2672 TR:P71969 (EMBL:Z80225) (528 aa), Fasta scores: E(): 0, 74.4% identity in 528 aa overlap. Contains a possible N-terminal signal sequence. Q7AQ63 No intermediary metabolism and respiration PF00561,PF08386 Q7AQ63 GO:0008233 Rv2672 Rv2672 AL450380.2 Mycobrowser_v4 CDS 1627537 1627728 . - 0 ML1366c ML1366c Probable catechol-o-methyltransferase (pseudogene) ML1366c, len: 192 bp. Possible pseudogene of M. tuberculosis orthologue Rv1703c (591 bp) (Best blastx scores: 219). Yes intermediary metabolism and respiration Rv1703c Rv1703c AL450380.2 Mycobrowser_v4 CDS 1741637 1742219 . - 0 ML1449c cobK Probable precorrin-6X reductase CobK (pseudogene) ML1449c, len: 583 bp. Possible pseudogene of M. tuberculosis orthologue cobK|Rv2070c (735 bp) (Best blastx scores: 178). Yes intermediary metabolism and respiration Rv2070c Rv2070c AL450380.2 Mycobrowser_v4 CDS 1742243 1742978 . - 0 ML1450c cobM Probable precorrin-4 C11-methyltransferase CobM (pseudogene) ML1450c, len: 736 bp. Possible pseudogene of M. tuberculosis orthologue cobM|Rv2071c (756 bp) (Best blastx scores: 341). Yes intermediary metabolism and respiration Rv2071c Rv2071c AL450380.2 Mycobrowser_v4 CDS 1633391 1634438 . - 0 ML1373c ML1373c Conserved hypothetical protein (pseudogene) ML1373c, len: 1048 bp. Possible pseudogene similar to the M. tuberculosis degenerate repetitive element REP13E12 family e.g. Rv1702c (1365 bp) (Best blastx scores: 97). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1635167 1635838 . + 0 ML1374 ML1374 Conserved hypothetical protein (pseudogene) ML1374, len: 672 bp. Possible pseudogene of M. tuberculosis orthologue Rv1716 (831 bp) (Best blastx scores: 261). Yes conserved hypotheticals Rv1716 Rv1716 AL450380.2 Mycobrowser_v4 CDS 1641396 1641861 . + 0 ML1377 ML1377 Conserved hypothetical protein (pseudogene) ML1377, len: 466 bp. Possible pseudogene of M. tuberculosis orthologue Rv1769 (1245 bp) (Best blastx scores: 218). Yes conserved hypotheticals Rv1769 Rv1769 AL450380.2 Mycobrowser_v4 CDS 1641984 1643179 . + 0 ML1378 ML1378 conserved hypothetical protein (pseudogene) ML1378, len: 1196 bp. Possible pseudogene of M. tuberculosis orthologue Rv1770 (1287 bp) (Best blastx scores: 305). Yes conserved hypotheticals Rv1770 Rv1770 AL450380.2 Mycobrowser_v4 CDS 1643196 1644454 . + 0 ML1379 ML1379 Probable oxidoreductase (pseudogene) ML1379, len: 1259 bp. Possible pseudogene of M. tuberculosis orthologue Rv1771 (1287 bp) (Best blastx scores: 462). Yes intermediary metabolism and respiration Rv1771 Rv1771 AL450380.2 Mycobrowser_v4 CDS 1618113 1618922 . + 0 ML1358 tlyA cytotoxin/hemolysin homologue TlyA ML1358, len: 269 aa. Probable tlyA, cytotoxin/haemolysin homologue. Highly similar to several proposed hemolysins including: Mycobacterium ulcerans TlyA TR:CAB83047 (EMBL:AJ271681) (281 aa), Fasta scores: E(): 0, 81.0% identity in 268 aa overlap, Treponema hyodysenteriae hemolysin A SW:HLYA_TREHY (Q06803) (240 aa), Fasta scores: E(): 2.3e-23, 34.9% identity in 238 aa overlap and Mycobacterium tuberculosis Rv1694 TR:Q50760 (EMBL:X98295) (268 aa), Fasta scores: E(): 0, 78.4% identity in 268 aa overlap. Contains possible membrane spanning hydrophobic domains. O05676 No virulence, detoxification, adaptation PF01479,PF01728 O05676 GO:0019836,GO:0003723 Rv1694 Rv1694 AL450380.2 Mycobrowser_v4 CDS 1656694 1659194 . - 0 ML1385c ML1385c Probable conserved transmembrane ATP-binding protein ABC transporter (pseudogene) ML1385c, len: 2501 bp. Possible pseudogene of M. tuberculosis orthologue Rv1747 (2598 bp) (Best blastx scores: 280). Yes cell wall and cell processes Rv1747 Rv1747 AL450380.2 Mycobrowser_v4 CDS 1659700 1660593 . + 0 ML1386 pknF Anchored membrane serine-threonine protein kinase PknF (pseudogene) ML1386, len: 894 bp. Possible pseudogene of M. tuberculosis orthologue pknF|Rv1746 (1431 bp) (Best blastx scores: 407). Also similar to ML1266c a possible pseudogene similar to M. tuberculosis pknF. Yes regulatory proteins Rv1746 Rv1746 AL450380.2 Mycobrowser_v4 CDS 1663851 1665183 . + 0 ML1388 ML1388 Possible drug efflux membrane protein (pseudogene) ML1388, len: 1333 bp. Possible pseudogene of M. tuberculosis orthologue Rv1634 (1416 bp) (Best blastx scores: 456). Yes cell wall and cell processes Rv1634 Rv1634 AL450380.2 Mycobrowser_v4 CDS 1743125 1745194 . + 0 ML1450A ML1450A Probable conserved transmembrane transport protein (pseudogene) ML1450A, len: 2070 bp. Possible pseudogene similar to several M. tuberculosis conserved transmembrane transport proteins e.g. Rv1557, Rv0676c, Rv2942, Rv2339 etc (Best blastx score: 277). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1678047 1679058 . - 0 ML1398c ML1398c Conserved hypothetical protein (pseudogene) ML1398c, len: 1012 bp. Possible pseudogene of M. tuberculosis orthologue Rv1645c (1056 bp) (Best blastx scores: 740). Yes conserved hypotheticals Rv1645c Rv1645c AL450380.2 Mycobrowser_v4 CDS 1680236 1680659 . + 0 ML1400 ML1400 Probable transmembrane protein (pseudogene) ML1400, len: 424 bp. Possible pseudogene of M. tuberculosis orthologue Rv1648 (807 bp) (Best blastx scores: 139). Yes cell wall and cell processes Rv1648 Rv1648 AL450380.2 Mycobrowser_v4 CDS 2253010 2253826 . - 0 ML1874c ML1874c Putative ferredoxin reductase (pseudogene) ML1874c, len: 817 bp. Possible pseudogene of M. tuberculosis orthologue Rv0688 (Best blastx scores: 266). Yes intermediary metabolism and respiration Rv0688 Rv0688 AL450380.2 Mycobrowser_v4 CDS 1656229 1656567 . + 0 ML1384 ML1384 hypothetical protein ML1384, len: 112 aa. Hypothetical unknown protein. Q9CC28 No unknown Q9CC28 AL450380.2 Mycobrowser_v4 CDS 1745350 1746075 . - 0 ML1451c ML1451c Conserved hypothetical protein (pseudogene) ML1451c, len: 726 bp. Possible pseudogene of M. tuberculosis orthologue Rv2417c (843 bp) (Best blastx scores: 354). Yes conserved hypotheticals Rv2417c Rv2417c AL450380.2 Mycobrowser_v4 CDS 1694888 1696300 . + 0 ML1413 argH Probable Argininosuccinate lyase ArgH ML1413, len: 470 aa. Probable argH, Argininosuccinate lyase (EC 4.3.2.1). Highly similar to many argininosuccinate lyases involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa), BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa), Fasta scores: E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. Q9CC09 No intermediary metabolism and respiration PF00206 Q9CC09 GO:0004056,GO:0005737,GO:0042450 4.3.2.1 Rv1659 Rv1659 AL450380.2 Mycobrowser_v4 CDS 1720213 1721344 . - 0 ML1434c lipT Probable carboxylesterase LipT (pseudogene) ML1434c, len: 1132 bp. Possible pseudogene of M. tuberculosis orthologue lipT|Rv2045c (1536 bp) (Best blastx scores: 360). Yes intermediary metabolism and respiration Rv2045c Rv2045c AL450380.2 Mycobrowser_v4 CDS 1721431 1722011 . + 0 ML1435 lppI Probable lipoprotein LppI (pseudogene) ML1435, len: 581 bp. Possible pseudogene of M. tuberculosis orthologue lppI|Rv2046 (657 bp) (Best blastx scores: 133). Yes cell wall and cell processes Rv2046 Rv2046 AL450380.2 Mycobrowser_v4 CDS 1723812 1726138 . - 0 ML1436c ML1436c Conserved hypothetical protein (pseudogene) ML1436c, len: 2327 bp. Possible pseudogene of M. tuberculosis orthologue Rv2047c (2565 bp) (Best blastx scores: 1206). Yes conserved hypotheticals Rv2047c Rv2047c AL450380.2 Mycobrowser_v4 CDS 1726368 1732457 . - 0 ML1437c pks12 Probable polyketide synthase Pks12 (pseudogene) ML1437c, len: 6090 bp. Possible pseudogene of M. tuberculosis orthologue pks12|Rv2048c (12456 bp) (Best blastx scores: 1700). Yes lipid metabolism Rv2048c Rv2048c AL450380.2 Mycobrowser_v4 CDS 1732857 1733040 . - 0 ML1438c ML1438c Hypothetical protein (pseudogene) ML1438c, len: 184 bp. Possible pseudogene of M. tuberculosis orthologue Rv2049c (225 bp) (Best blastx scores: 101). Yes conserved hypotheticals Rv2049c Rv2049c AL450380.2 Mycobrowser_v4 CDS 2743453 2744139 . + 0 ML2315 ML2315 Conserved hypothetical protein (pseudogene) ML2315, len: 687 bp. Possible pseudogene of M. tuberculosis orthologue Rv3698 (1530 bp) (Best blastx scores: 315). Yes conserved hypotheticals Rv3698 Rv3698 AL450380.2 Mycobrowser_v4 CDS 1749447 1750789 . - 0 ML1456c ML1456c Conserved hypothetical protein (pseudogene) ML1456c, len: 1343 bp. Possible pseudogene of M. tuberculosis orthologue Rv2425c (1443 bp) (Best blastx scores: 490). Yes conserved hypotheticals Rv2425c Rv2425c AL450380.2 Mycobrowser_v4 CDS 1750820 1751684 . - 0 ML1457c ML1457c Conserved hypothetical protein (pseudogene) ML1457c, len: 865 bp. Possible pseudogene of M. tuberculosis orthologue Rv2426c (876 bp) (Best blastx scores: 304). Yes conserved hypotheticals Rv2426c Rv2426c AL450380.2 Mycobrowser_v4 CDS 1739655 1739879 . - 0 ML1445c ML1445c hypothetical protein ML1445c, len: 74 aa. Hypothetical unknown protein. Q9CC03 No unknown Q9CC03 AL450380.2 Mycobrowser_v4 CDS 1738599 1739297 . + 0 ML1444 ML1444 CONSERVED HYPOTHETICAL PROTEIN ML1444, len: 232 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis Rv2054 TR:O86353 (EMBL:AL021899) Conserved hypothetical protein (237 aa), Fasta scores: E(): 0, 76.1% identity in 230 aa overlap. Weakly similar to several carboxymethylenebutenolidases (EC 3.1.1.45) involved in 3-chlorocatechol degradation e.g. Pseudomonas putida SW:CLCD_PSEPU (P11453) (236 aa), Fasta scores: E(): 7.6e-06, 28.6% identity in 234 aa overlap. Contains Pfam match to entry PF01738 DLH, Dienelactone hydrolase family. Q9CC04 No conserved hypotheticals PF01738 Q9CC04 GO:0016787 Rv2054 Rv2054 AL450380.2 Mycobrowser_v4 CDS 1764507 1764818 . - 0 ML1467c rplU PROBABLE 50S RIBOSOMAL PROTEIN L21 RPLU ML1467c, len: 103 aa. Probable 50S ribosomal protein L21. Highly similar to many 50s ribosomal proteins (L21) including: Escherichia coli SW:RL21_ECOLI (P02422) (103 aa), Fasta scores: E(): 9.8e-11, 37.0% identity in 100 aa overlap and Mycobacterium tuberculosis Rv2442c SW:RL21_MYCTU (p71907) (104 aa), Fasta scores: E(): 0, 91.2% identity in 102 aa overlap. Contains Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein. Q9CBZ2 No information pathways PF00829 Q9CBZ2 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv2442c Rv2442c AL450380.2 Mycobrowser_v4 CDS 2876799 2877306 . - 0 ML2405c pnp Probable 5'-methylthioadenosine phosphorylase Pnp (pseudogene) ML2405c, len: 508 bp. Possible pseudogene of M. tuberculosis orthologue pnp|Rv0535 (795 bp) (Best blastx scores: 196). Yes intermediary metabolism and respiration Rv0535 Rv0535 AL450380.2 Mycobrowser_v4 CDS 2878880 2880000 . - 0 ML2408c ML2408c Conserved hypothetical protein (pseudogene) ML2408c, len: 1121 bp. Possible pseudogene of M. tuberculosis orthologue Rv0530 (1218 bp) (Best blastx scores: 266). Yes conserved hypotheticals Rv0530 Rv0530 AL450380.2 Mycobrowser_v4 CDS 1768162 1768572 . - 0 ML1469c ndk PROBABLE NUCLEOSIDE DIPHOSPHATE KINASE NDK (NDK) (NDP KINASE) (NUCLEOSIDE-2-P KINASE) ML1469c, len: 136 aa. Probable nucleoside diphosphate kinases (EC 2.7.4.6). Highly similar to many nucleoside diphosphate kinases including: Bacillus subtilis SW:NDK_BACSU (P31103) (149 aa), Fasta scores: E(): 5e-27, 55.7% identity in 131 aa overlap and Mycobacterium tuberculosis Rv2445c SW:NDK_MYCTU (P71904) (136 aa), Fasta scores: E(): 0, 87.4% identity in 135 aa overlap. Contains Pfam match to entry PF00334 NDK, Nucleoside diphosphate kinases. Q9CBZ0 No intermediary metabolism and respiration PF00334 Q9CBZ0 GO:0006241,GO:0006183,GO:0006228,GO:0005737,GO:0000287,GO:0004550,GO:0005524 2.7.4.6 Rv2445c Rv2445c AL450380.2 Mycobrowser_v4 CDS 1838491 1839729 . - 0 ML1524c ML1524c Probable fatty-acid-CoA synthetase (pseudogene) ML1524c, len: 1239 bp. Possible pseudogene similar to several M. tuberculosis fatty-acid-CoA ligases e.g fadD7|Rv0119, fadD35|Rv2505c, fadD13|Rv3089 etc (Best blastx scores: 127). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1761568 1762671 . - 0 ML1464c proB INVOLVED IN PROLINE BIOSYNTHESIS PATHWAY (AT THE FIRST STEP). CATALYZES THE TRANSFER OF A PHOSPHATE GROUP TO GLUTAMATE TO FORM GLUTAMATE 5-PHOSPHATE WHICH RAPIDLY CYCLIZES TO 5-OXOPROLINE [CATALYTIC ACTIVITY: ATP + L-GLUTAMATE = ADP + L-GLUTAMATE 5- PHOSPHATE]. PROBABLE GLUTAMATE 5-KINASE PROTEIN PROB (GAMMA-GLUTAMYL KINASE) (GK) ML1464c, len: 367 aa.Probable proB, glutamate 5-kinase protein (GK) (EC 2.7.2.11). Highly similar to many glutamate 5-kinases involved in proline biosynthesis e.g. Escherichia coli SW:PROB_ECOLI (P07005) (367 aa), Fasta scores: E(): 0, 39.3% identity in 364 aa overlap and Mycobacterium tuberculosis Rv2439c SW:PROB_MYCTU (P71910) (376 aa), Fasta scores: E(): 0, 84.4% identity in 366 aa overlap. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01472 PUA, PUA domain. Contains PS00902 Glutamate 5-kinase signature. BELONGS TO THE GLUTAMATE 5-KINASE FAMILY. Q9CBZ5 No intermediary metabolism and respiration PF00696,PF01472 Q9CBZ5 GO:0003723,GO:0005737,GO:0004349,GO:0006561,GO:0005524 2.7.2.11 Rv2439c Rv2439c AL450380.2 Mycobrowser_v4 CDS 1777926 1779439 . - 0 ML1476c ML1476c Probable oxidoreductase alpha subunit (pseudogene) ML1476c, len: 1514 bp. Possible pseudogene of M. tuberculosis orthologue Rv2455c (1962 bp) (Best blastx scores: 483). Yes intermediary metabolism and respiration Rv2455c Rv2455c AL450380.2 Mycobrowser_v4 CDS 1785379 1786467 . + 0 ML1482 lipP Probable esterase/lipase LipP (pseudogene) ML1482, len: 1089 bp. Possible pseudogene of M. tuberculosis orthologue lipP|Rv2463 (1185 bp) (Best blastx scores: 423). Yes intermediary metabolism and respiration Rv2463 Rv2463 AL450380.2 Mycobrowser_v4 CDS 1786565 1787380 . - 0 ML1483c ML1483c Possible DNA glycosylase (pseudogene) ML1483c, len: 816 bp. Possible pseudogene of M. tuberculosis orthologue Rv2464c (807 bp) (Best blastx scores: 234). Yes information pathways Rv2464c Rv2464c AL450380.2 Mycobrowser_v4 CDS 1792962 1794065 . - 0 ML1488c ML1488c PROBABLE AMINOTRANSFERASE ML1488c, len: 367 aa. Probable aminotransferase. Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa), Fasta scores: E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis Rv1178 TR:O50434 (EMBL:AL010186) (362 aa), Fasta scores: E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. Q9CBX8 No intermediary metabolism and respiration PF00155 Q9CBX8 GO:0009058,GO:0030170,GO:0008483,GO:0016847 Rv1178 Rv1178 AL450380.2 Mycobrowser_v4 CDS 1808283 1808875 . - 0 ML1500c narJ Probable respiratory nitrate reductase (delta chain) NarJ (pseudogene) ML1500c, len: 593 bp. Possible pseudogene of M. tuberculosis orthologue narJ|Rv1163 (606 bp) (Best blastx scores: 371). Yes intermediary metabolism and respiration Rv1163 Rv1163 AL450380.2 Mycobrowser_v4 CDS 1809062 1810604 . - 0 ML1501c narH Probable respiratory nitrate reductase (beta chain) NarH (pseudogene) ML1501c, len: 1543 bp. Possible pseudogene of M. tuberculosis orthologue narH|Rv1162 (1677 bp) (Best blastx scores: 717). Yes intermediary metabolism and respiration Rv1162 Rv1162 AL450380.2 Mycobrowser_v4 CDS 1820852 1821192 . - 0 ML1510c ML1510c Probable transcriptional regulatory protein (pseudogene) ML1510c, len: 341 bp. Possible pseudogene of M. tuberculosis orthologue Rv1152 (366 bp) (Best blastx scores: 173). Yes regulatory proteins Rv1152 Rv1152 AL450380.2 Mycobrowser_v4 CDS 2888135 2889432 . - 0 ML2416c gabP Probable 4-amino butyrate transporter GabP (pseudogene) ML2416c, len: 1298 bp. Possible pseudogene of M. tuberculosis orthologue gabP|Rv0522 (1305 bp) (Best blastx scores: 474). Yes cell wall and cell processes Rv0522 Rv0522 AL450380.2 Mycobrowser_v4 CDS 1815095 1815379 . + 0 ML1503A ML1503A conserved hypothetical protein ML1503A, len: 94 aa. Conserved hypothetical protein, orthologous to M. tuberculosis Rv1159A and similar to hypothetical proteins in Streptomyces coelicolor (SC5C7.25) and archaebacteria. FASTA scores: Rv1159A E(): 9e-33, 66/93 aa (70%) identical, and gp|AL03151 5AL031515|AL031515_25 Streptomyces coelicolor (101 aa) E(): 1.9e-06; 34.831% identity in 89 aa overlap Q9CBX1 No conserved hypotheticals Q9CBX1 Rv1159A Rv1159A AL450380.2 Mycobrowser_v4 CDS 1887930 1889136 . - 0 ML1563c cysG Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase, precorrin-2 oxidase and ferrochelatase (pseudogene) ML1563c, len: 1207 bp. Possible pseudogene of M. tuberculosis orthologue cysG|Rv2847c (1218 bp) (Best blastx scores: 286). Yes intermediary metabolism and respiration Rv2847c Rv2847c AL450380.2 Mycobrowser_v4 CDS 2744237 2744734 . + 0 ML2316 ML2316 Conserved hypothetical protein (pseudogene) ML2316, len: 498 bp. Possible pseudogene of M. tuberculosis orthologue Rv3699 (702 bp) (Best blastx scores: 159). Yes conserved hypotheticals Rv3699 Rv3699 AL450380.2 Mycobrowser_v4 CDS 1827781 1828791 . - 0 ML1514A ML1514A Hypothetical protein (pseudogene) ML1514A, len: 765 bp. Possible pseudogene similar to other hypothetical and efflux proteins e.g. Q82BT8 Hypothetical protein from Streptomyces avermitilis (Best blastx score: 229). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1829959 1831159 . - 0 ML1516c hsdM Possible type I restriction/modification system DNA methylase HsdM (pseudogene) ML1516c, len: 1201 bp. Possible pseudogene of M. tuberculosis orthologue hsdM|Rv2756c (1623 bp) (Best blastx scores: 272). Yes information pathways Rv2756c Rv2756c AL450380.2 Mycobrowser_v4 CDS 1831358 1832332 . - 0 ML1517c ML1517c hypothetical protein (pseudogene) ML1517c, len: 975 bp. Possible pseudogene, similar to several hypothetical proteins e.g. Q9HZZ9 Hypothetical protein PA2844 from Pseudomonas aeruginosa (402 aa) (Best blastx score: 161). Q9CBW2 Yes unknown PF06224 Q9CBW2 AL450380.2 Mycobrowser_v4 CDS 1834922 1836705 . - 0 ML1521c ML1521c Probable acyl-CoA dehydrogenase (pseudogene) ML1521c, len: 1784 bp. Possible pseudogene similar to several M. tuberculosis acyl-CoA dehydrogenases e.g fadE34|Rv3573c, fadE6|Rv0271, fadE33|Rv3564 etc (Best blastx scores: 108). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1554169 1555686 . - 0 ML1305c ansP2 POSSIBLE L-ASPARAGINE PERMEASE ANSP2 (L-ASPARAGINE TRANSPORT PROTEIN) ML1305c, len: 505 aa. Probable ansP2, L-asparagine permease. Highly similar to many L-asparagine transport proteins including: Salmonella typhimurium AnsP SW:ANSP_SALTY (P40812) (497 aa), Fasta scores: E(): 0, 58.9% identity in 477 aa overlap and Mycobacterium tuberculosis Rv2127 SW:ANSP_MYCTU (O33261) (489 aa), Fasta scores: E(): 0, 83.7% identity in 485 aa overlap and O06297|Rv0346c Possible ansP2, L-asparagine permease (487 aa), fasta scores: E(): 1.8e-129, (69.76% identity in 473 aa overlap). Almost identical to the duplicated sequence ML1304. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains PS00218 Amino acid permeases signature. Q9S379 No cell wall and cell processes PF00324 Q9S379 GO:0006865,GO:0016021,GO:0015171 Rv0346c Rv0346c AL450380.2 Mycobrowser_v4 CDS 1874332 1875433 . + 0 ML1550 ML1550 Possible hydrolase (pseudogene) ML1550, len: 1102 bp. Possible pseudogene of M. tuberculosis orthologue Rv2800 (1650 bp) (Best blastx scores: 259). Yes intermediary metabolism and respiration Rv2800 Rv2800 AL450380.2 Mycobrowser_v4 CDS 1878744 1879700 . - 0 ML1554c ML1554c Conserved hypothetical protein (pseudogene) ML1554c, len: 957 bp. Possible pseudogene of M. tuberculosis orthologue Rv2837c (1011 bp) (Best blastx scores: 178). Yes conserved hypotheticals Rv2837c Rv2837c AL450380.2 Mycobrowser_v4 CDS 2835136 2835920 . + 0 ML2367 proX Possible osmoprotectant binding lipoprotein ProX (pseudogene) ML2367, len: 785 bp. Possible pseudogene of M. tuberculosis orthologue proX|Rv3759c (948 bp) (Best blastx scores: 216). Yes virulence, detoxification, adaptation Rv3759c Rv3759c AL450380.2 Mycobrowser_v4 CDS 1654204 1655436 . + 0 ML1383 coaE Probable dephospho-CoA kinase CoaE (dephosphocoenzyme A kinase) ML1383, len: 410 aa. Probable coaE, dephospho-CoA kinase (EC 2.7.1.24). Highly similar to many e.g. Mycobacterium tuberculosis Rv1631 SW:YG31_MYCTU (O06148) (407 aa), Fasta scores: E(): 0, 77.5% identity in 409 aa overlap and Q9S2K7|COAE_STRCO Dephospho-CoA kinase from Streptomyces coelicolor (200 aa), fasta scores: E(): 8e-32, (51.053% identity in 190 aa overlap). Contains Pfam match to entry PF01121 UPF0038, Uncharacterized protein family UPF0038. Contains PS01294 Uncharacterized protein family UPF0038 signature. Q50178 No intermediary metabolism and respiration PF01121,PF04229 Q50178 GO:0015937,GO:0005737,GO:0004140,GO:0005524 2.7.1.24 Rv1631 Rv1631 AL450380.2 Mycobrowser_v4 CDS 1549223 1550038 . + 0 ML1301 cysQ POSSIBLE MONOPHOSPHATASE CYSQ ML1301, len: 271 aa. POssible cysQ, monophosphatase. Similar to several inositol monophosphatase family proteins including: Escherichia coli CysQ SW:CYSQ_ECOLI (P22255) (246 aa), Fasta scores: E(): 9.6e-07, 31.3% identity in 217 aa overlap and Mycobacterium tuberculosis CysQ protein homolog Rv2131c SW:CYSQ_MYCTU (O06244) (267 aa), Fasta scores: E(): 0, 76.0% identity in 271 aa overlap. Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family. Contains PS00629 Inositol monophosphatase family signature 1. Belongs to the inositol monophosphatase family. P46726 No intermediary metabolism and respiration PF00459 P46726 GO:0000287,GO:0004437 3.1.3.- Rv2131c Rv2131c AL450380.2 Mycobrowser_v4 CDS 2842071 2842467 . - 0 ML2374c ML2374c Possible integral membrane c-type cytochrome biogenesis protein (pseudogene) ML2374c, len: 397 bp. Possible pseudogene similar to M. tuberculosis Rv2874|dipZ (2088 bp) (Best blastx scores: 141). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1562248 1563117 . + 0 ML1310 hisG Probable ATP phosphoribosyltransferase HisG ML1310, len: 289 aa. Probable hisG, ATP phosphoribosyltransferase (EC 2.4.2.17). Highly similar to many ATP phosphoribosyltransferases involved in histidine biosynthesis, including: Sulfolobus solfataricus HisG SW:HIS1_SULSO (O33771) (290 aa), Fasta scores: E(): 4e-20, 32.0% identity in 291 aa overlap and Mycobacterium tuberculosis Rv2121c SW:HIS1_MYCTU (O33256) (284 aa), Fasta scores: E(): 0, 87.8% identity in 287 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase. Contains Pfam match to entry PF01634 HisG, ATP phosphoribosyltransferase. Contains PS01316 ATP phosphoribosyltransferase signature. Q49776 No intermediary metabolism and respiration PF01634,PF08029 Q49776 GO:0003879,GO:0005737,GO:0000105,GO:0000287,GO:0005524 2.4.2.17 Rv2121c Rv2121c AL450380.2 Mycobrowser_v4 CDS 2530694 2530855 . - 0 ML2129c ML2129c PE-family protein (pseudogene) ML2129c, len: 53 aa. Possible pseudogene similar to Mycobacterium tuberculosis PE-family protein O53690|AL021930 fasta scores: E(): 1.6e-05, 60.7% in 56 aa. most similar to PE29, PE5 and PE15 Yes unknown AL450380.2 Mycobrowser_v4 CDS 2535359 2535797 . + 0 ML2133 ML2133 Conserved hypothetical protein (pseudogene) ML2133, len: 439 bp. Possible pseudogene of M. tuberculosis orthologue Rv0887c (459 bp) (Best blastx scores: 221). Yes conserved hypotheticals Rv0887c Rv0887c AL450380.2 Mycobrowser_v4 CDS 2836546 2836768 . - 0 ML2368c ML2368c Probable transposase (pseudogene) ML2368c, len: 223 bp. Possible pseudogene similar to M. tuberculosis Rv3798 (1335 bp) (Best blastx scores: 52). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2842603 2844885 . - 0 ML2375c ML2375c Probable conserved transmembrane transport protein (pseudogene) ML2375c, len: 2283 bp. Possible pseudogene similar to M. tuberculosis mmpL4|Rv0450c (2904 bp) (Best blastx scores: 1169), a orthologue of mmpL4 exist just upstream in M. leprae at ML2378. Yes unknown AL450380.2 Mycobrowser_v4 CDS 1746891 1747565 . - 0 ML1452c ML1452c PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) ML1452c, len: 224 aa. Probable phosphoglycerate mutase (EC 5.4.2.1). Similar to several including: Mycobacterium tuberculosis Rv2419c TR:P71724 (EMBL:Z81368) (223 aa), Fasta scores: E(): 0, 80.4% identity in 224 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. BELONGS TO THE PHOSPHOGLYCERATE MUTASE FAMILY. Q9CC00 No intermediary metabolism and respiration PF00300 Q9CC00 GO:0008152,GO:0003824 Rv2419c Rv2419c AL450380.2 Mycobrowser_v4 CDS 1682090 1684600 . + 0 ML1402 pheT Probable phenylalanyl-tRNA synthetase, beta chain PheT ML1402, len: 836 aa. Probable pheT, phenylalanyl-tRNA synthetase, beta chain (EC 6.1.1.20). Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa), Fasta scores: E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis Rv1650|P94985|SYFB_MYCTU Phenylalanyl-tRNA synthetase beta (831 aa), fasta scores: E(): 0, (79.616% identity in 834 aa overlap). Q9CC16 No information pathways PF01588,PF03147,PF03483,PF03484 Q9CC16 GO:0005737,GO:0000287,GO:0004826,GO:0006432,GO:0000049,GO:0008033,GO:0005524 6.1.1.20 Rv1650 Rv1650 AL450380.2 Mycobrowser_v4 CDS 2928934 2929334 . - 0 ML2455c ML2455c Probable transcriptional regulatory protein (pseudogene) ML2455c, len: 401 bp. Possible pseudogene of M. tuberculosis orthologue Rv0474 (423 bp) (Best blastx scores: 189). Yes regulatory proteins Rv0474 Rv0474 AL450380.2 Mycobrowser_v4 CDS 1618919 1619854 . + 0 ML1359 ppnK Inorganic polyphosphate/ATP-NAD kinase PpnK (Poly(P)/ATP NAD kinase) ML1359, len: 311 aa. Probable ppnK, Inorganic polyphosphate/ATP-NAD kinase (EC 2.7.1.23). Similar to many others including: Streptomyces coelicolor TR:Q9S219 (EMBL:AL109848) (301 aa), Fasta scores: E(): 0, 54.5% identity in 303 aa overlap and Mycobacterium tuberculosis Rv1695 SW:YG95_MYCTU (O33196) (307 aa), Fasta scores: E(): 0, 87.9% identity in 305 aa overlap. Contains Pfam match to entry PF01513 DUF15, Domain of unknown function. Q49897 No intermediary metabolism and respiration PF01513 Q49897 GO:0003951,GO:0005737,GO:0008152,GO:0046872,GO:0005524 2.7.1.23 Rv1695 Rv1695 AL450380.2 Mycobrowser_v4 CDS 1532567 1533761 . - 0 ML1287c ML1287c Probable nonspecific lipid-transfer protein (pseudogene) ML1287c, len: 1194 bp. Possible pseudogene of M. tuberculosis orthologue Rv1627c (1209 bp) (Best blastx scores: 235). Yes lipid metabolism Rv1627c Rv1627c AL450380.2 Mycobrowser_v4 CDS 1843931 1844865 . - 0 ML1529c ML1529c Probable oxidoreductase (pseudogene) ML1529c, len: 935 bp. Possible pseudogene of M. tuberculosis orthologue Rv2776c (930 bp) (Best blastx scores: 445). Also similar to ML1758c possible pseudogene similar to M. tuberculosis Rv2776c. Yes intermediary metabolism and respiration Rv2776c Rv2776c AL450380.2 Mycobrowser_v4 CDS 1860616 1860789 . - 0 ML1541c ML1541c Probable ferredoxin (pseudogene) ML1541c, len: 174 bp. Possible pseudogene of M. tuberculosis orthologue Rv1786 (204 bp0 (Best blastx scores: 147). Yes intermediary metabolism and respiration Rv1786 Rv1786 AL450380.2 Mycobrowser_v4 CDS 1861016 1862166 . + 0 ML1542 cyp143 Probable cytochrome P450 Cyp143 (pseudogene) ML1542, len: 1151 bp. Possible pseudogene of M. tuberculosis orthologue Rv1785c|cyp143 (1182 bp) (Best blastx scores: 322). Yes intermediary metabolism and respiration Rv1785c Rv1785c AL450380.2 Mycobrowser_v4 CDS 1842581 1843888 . + 0 ML1528 ML1528 Conserved hypothetical protein (pseudogene) ML1528, len: 1308 bp. Possible pseudogene similar to several M. tuberculosis proteins in REP13E12 repeats e.g. Rv1128, Rv1148 and Rv1945 (Best blastx scores: 194). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1845381 1846353 . - 0 ML1530c ML1530c Conserved hypothetical protein (pseudogene) ML1530c, len: 973 bp. Possible pseudogene of M. tuberculosis orthologue Rv2777c (1071 bp) (Best blastx scores: 581). Yes conserved hypotheticals Rv2777c Rv2777c AL450380.2 Mycobrowser_v4 CDS 1846363 1846797 . - 0 ML1531c ML1531c Possible transcriptional regulatory protein (Lrp/AsnC family) (pseudogene) ML1531c, len: 435 bp. Possible pseudogene of M. tuberculosis orthologue Rv2779c (540 bp) (Best blastx scores: 211). Yes regulatory proteins Rv2779c Rv2779c AL450380.2 Mycobrowser_v4 CDS 1840963 1841694 . - 0 ML1527c dapB Dihydrodipicolinate reductase DapB (pseudogene) ML1527c, len: 731 bp. Possible pseudogene of M. tuberculosis orthologue dapB|Rv2773c (738 bp) (Best blastx scores: 605). Yes intermediary metabolism and respiration Rv2773c Rv2773c AL450380.2 Mycobrowser_v4 CDS 1892390 1893863 . - 0 ML1568c mqo Probable malate:quinone oxidoreductase Mqo (pseudogene) ML1568c, len: 1474 bp. Possible pseudogene of M. tuberculosis orthologue Rv2852c|mqo (1482 bp) (Best blastx scores: 535). Yes intermediary metabolism and respiration Rv2852c Rv2852c AL450380.2 Mycobrowser_v4 CDS 1894014 1894986 . + 0 ML1569 ML1569 Hypothetical protein (pseudogene) ML1569, len: 973 bp. Possible pseudogene of M. tuberculosis orthologue Rv2854 (1041 bp) (Best blastx scores: 330). Yes conserved hypotheticals Rv2854 Rv2854 AL450380.2 Mycobrowser_v4 CDS 1895087 1896443 . + 0 ML1570 mtr NADPH-dependent mycothiol reductase Mtr (pseudogene) ML1570, len: 1357 bp. Possible pseudogene of M. tuberculosis orthologue mtr|Rv2855 (1380 bp) (Best blastx scores: 595) but previously described as glutathione reductase homolog (gene name: gorA). Yes intermediary metabolism and respiration Rv2855 Rv2855 AL450380.2 Mycobrowser_v4 CDS 1873756 1874284 . + 0 ML1549 ML1549 Probable membrane protein (pseudogene) ML1549, len: 529 bp. Possible pseudogene of M. tuberculosis orthologue Rv2799 (630 bp) (Best blastx scores: 220). Yes cell wall and cell processes Rv2799 Rv2799 AL450380.2 Mycobrowser_v4 CDS 1770444 1773104 . - 0 ML1472c valS PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. ML1472c, len: 886 aa. Probable valS, valyl-tRNA synthase (EC 6.1.1.9). Highly similar to many valyl-tRNA synthetases including: Bacillus stearothermophilus SW:SYV_BACST (P11931) (880 aa), Fasta scores: E(): 0, 46.6% identity in 894 aa overlap and Mycobacterium tuberculosis Rv2448c SW:SYV_MYCTU (O53175) (876 aa), Fasta scores: E(): 0, 85.4% identity in 876 aa overlap. Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Q9CBY7 No information pathways PF00133,PF08264,PF10458 Q9CBY7 GO:0005737,GO:0004832,GO:0006438,GO:0005524 6.1.1.9 Rv2448c Rv2448c AL450380.2 Mycobrowser_v4 CDS 1891169 1892064 . - 0 ML1566c ML1566c Possible magnesium-chelatase (pseudogene) ML1566c, len: 896 bp. Possible pseudogene of M. tuberculosis orthologue Rv2850c (1890 bp) (Best blastx scores: 295). Yes intermediary metabolism and respiration Rv2850c Rv2850c AL450380.2 Mycobrowser_v4 CDS 1892069 1892381 . - 0 ML1567c ML1567c Conserved hypothetical protein (pseudogene) ML1567c, len: 313 bp. Possible pseudogene of M. tuberculosis orthologue Rv2851c (471 bp) (Best blastx scores: 221). Yes intermediary metabolism and respiration Rv2851c Rv2851c AL450380.2 Mycobrowser_v4 CDS 1890870 1891101 . - 0 ML1565c cobO Probable cob(I)alamin adenosyltransferase CobO (pseudogene) ML1565c, len: 232 bp. Possible pseudogene of M. tuberculosis orthologue cobO|Rv2849c (624 bp) (Best blastx scores: 168). Yes intermediary metabolism and respiration Rv2849c Rv2849c AL450380.2 Mycobrowser_v4 CDS 1899803 1900060 . - 0 ML1574c glnA4 Proable glutamine synthetase GlnA4 (pseudogene) ML1574c, len: 258 bp. Possible pseudogene of M. tuberculosis orthologue glnA4|Rv2860c (1374 bp) (Best blastx scores: 129). Yes intermediary metabolism and respiration Rv2860c Rv2860c AL450380.2 Mycobrowser_v4 CDS 1920498 1920913 . + 0 ML1595 ML1595 Probable transcriptional regulatory protein (pseudogene) ML1595, len: 416 bp. Possible pseudogene of M. tuberculosis orthologue Rv2887 (420 bp) (Best blastx scores: 208). Yes regulatory proteins Rv2887 Rv2887 AL450380.2 Mycobrowser_v4 CDS 2031714 2032421 . + 0 ML1686 ML1686 Probable transcriptional regulatory protein (IclR family) (pseudogene) ML1686, len: 708 bp. Possible pseudogene of M. tuberculosis orthologue Rv2989 (702 bp) (Best blastx scores: 788). Yes regulatory proteins Rv2989 Rv2989 AL450380.2 Mycobrowser_v4 CDS 2062149 2062849 . - 0 ML1709c ML1709c Conserved hypothetical protein (pseudogene) ML1709c, len: 701 bp. Possible pseudogene of M. tuberculosis orthologue Rv3026c (915 bp) (Best blastx scores: 316). Yes conserved hypotheticals Rv3026c Rv3026c AL450380.2 Mycobrowser_v4 CDS 1851131 1851441 . + 0 ML1535 ML1535 Hypothetical protein (pseudogene) ML1535, len: 311 bp. Possible pseudogene of M. tuberculosis orthologue Rv1805c (348 bp) (Best blastx scores: 106). Also similar to ML2668 a possible pseudogene similar to M. tuberculosis Rv1805c. Yes conserved hypotheticals Rv1805c Rv1805c AL450380.2 Mycobrowser_v4 CDS 1876266 1876993 . + 0 ML1552 echA16 Probable enoyl-CoA hydratase EchA16 (pseudogene) ML1552, len: 728 bp. Possible pseudogene of M. tuberculosis orthologue echA16|Rv2831 (Best blastx scores: 202) Yes lipid metabolism Rv2831 Rv2831 AL450380.2 Mycobrowser_v4 CDS 2696143 2697235 . + 0 ML2272 pimB Mannosyltransferase PimB (pseudogene) ML2272, len: 1093 bp. Possible pseudogene of M. tuberculosis orthologue Rv0557|pimB (1137 bp) (Best blastx scores: 351). Yes lipid metabolism Rv0557 Rv0557 AL450380.2 Mycobrowser_v4 CDS 2113897 2114511 . - 0 ML1749c ML1749c Putative transposase (pseudogene) ML1749c, len: 615 bp. Possible pseudogene similar to M. smegmatis putative IS1549 transposase (Best blastx scores: 144). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1883022 1883342 . - 0 ML1557c ML1557c conserved hypothetical protein ML1557c, len: 106 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis Rv2840c TR:P71612 (EMBL:Z81331) (99 aa), Fasta scores: E(): 1.7e-30, 81.3% identity in 96 aa overlap. Q7AQ43 No conserved hypotheticals PF04296 Q7AQ43 Rv2840c Rv2840c AL450380.2 Mycobrowser_v4 CDS 2301184 2301801 . + 0 ML1917 ML1917 Conserved hypothetical protein (pseudogene) ML1917, len: 618 bp. Possible pseudogene of M. tuberculosis orthologue Rv3586 (1077 bp) (Best blastx scores: 150). Yes conserved hypotheticals Rv3586 Rv3586 AL450380.2 Mycobrowser_v4 CDS 1858301 1859203 . - 0 ML1540c ML1540c conserved hypothetical protein ML1540c, len: 300 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1794 TR:O53943 (EMBL:AL022021) (300 aa), Fasta scores: E(): 0, 88.0% identity in 300 aa overlap. Q7AQ48 No conserved hypotheticals Q7AQ48 Rv1794 Rv1794 AL450380.2 Mycobrowser_v4 CDS 2163362 2163826 . - 0 ML1788c ML1788c hypothetical protein ML1788c, len: 154 aa. Hypothetical unknown protein (questionable CDS). Q7AQ24 No unknown Q7AQ24 AL450380.2 Mycobrowser_v4 CDS 2261460 2262245 . - 0 ML1881c ML1881c Probable methyltransferase (pseudogene) ML1881c, len: 786 bp. Possible pseudogene similar to M. tuberculosis Rv2952 (813 bp) (Best blastx scores: 305). Also similar to ML0130c a possible orthologue of M. tuberculosis Rv2952. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2433036 2433623 . + 0 ML2042 ahpC ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C) ML2042, len: 195 aa. Probable ahpC, alkyl hydroperoxide reductase (EC 1.-.-.-). Similar to several e.g. Mycobacterium avium TR:Q57413 (EMBL:U18263) fasta scores: E(): 0, 86.2% in 195 aa, and to Streptomyces viridosporus TR:Q9X5V0 (EMBL:AF127576) fasta scores: E(): 0, 58.7% in 189 aa and Q57348 Rv2428 M. tuberculosis (195 aa), fasta scores: E(): 1.6e-75, (86.667% identity in 195 aa overlap). Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family. Q9CBF5 No virulence, detoxification, adaptation PF00578 Q9CBF5 GO:0045454,GO:0016491,GO:0016209 Rv2428 Rv2428 AL450380.2 Mycobrowser_v4 CDS 1884588 1885117 . - 0 ML1559c ML1559c Conserved hypothetical protein (pseudogene) ML1559c, len: 530 bp. Possible pseudogene of M. tuberculosis orthologue Rv2842c (552 bp) (Best blastx scores: 293). Q9Z5J2 Yes conserved hypotheticals PF02576 Q9Z5J2 Rv2842c Rv2842c AL450380.2 Mycobrowser_v4 CDS 1889194 1890521 . - 0 ML1564c cobB Probable cobyrinic acid a,c-diamide synthase CobB (pseudogene) ML1564c, len: 1328 bp. Possible pseudogene of M. tuberculosis orthologue cobB|Rv2848c (Best blastx scores: 390). Yes intermediary metabolism and respiration Rv2848c Rv2848c AL450380.2 Mycobrowser_v4 CDS 1896813 1897745 . + 0 ML1571 nicT Probable nickel transport integral membrane protein NicT (pseudogene) ML1571, len: 933 bp. Possible pseudogene of M. tuberculosis orthologue nicT|Rv2856 (1119 bp) (Best blastx scores: 614). Yes cell wall and cell processes Rv2856 Rv2856 AL450380.2 Mycobrowser_v4 CDS 1904954 1905684 . - 0 ML1580c ML1580c Conserved hypothetical protein (pseudogene) ML1580c, len: 731 bp. Possible pseudogene of M. tuberculosis orthologue Rv2867c (855 bp) (Best blastx scores: 382). Yes intermediary metabolism and respiration Rv2867c Rv2867c AL450380.2 Mycobrowser_v4 CDS 2201937 2202294 . - 0 ML1819c ctpD Probable cation transporter P-type ATPase D CtpD (pseudogene) ML1819c, len: 358 bp. Possible pseudogene of M. tuberculosis orthologue Rv1469|ctpD (1974 bp) (Best blastx scores: 206). Yes cell wall and cell processes Rv1469 Rv1469 AL450380.2 Mycobrowser_v4 CDS 1885245 1885781 . + 0 ML1560 ML1560 conserved hypothetical protein ML1560, len: 178 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2843 TR:O05816 (EMBL:Z95207) (181 aa), Fasta scores: E(): 2e-31, 70.2% identity in 168 aa overlap. Q7AQ42 No conserved hypotheticals, cell wall and cell processes Q7AQ42 Rv2843 Rv2843 AL450380.2 Mycobrowser_v4 CDS 1898130 1898528 . + 0 ML1572 ML1572 hypothetical protein ML1572, len: 132 aa. Hypothetical unknown protein, some similarity to O50518 Hypothetical protein SCO5844 from Streptomyces coelicolor (397 aa), fasta scores: E(): 8.1e-07, (35.135% identity in 111 aa overlap) Q9CBV0 No unknown PF01663 Q9CBV0 GO:0008152,GO:0003824 AL450380.2 Mycobrowser_v4 CDS 1900175 1900468 . - 0 ML1575c ML1575c hypothetical protein ML1575c, len: 97 aa. Hypothetical unknown protein. Q9CBU8 No unknown Q9CBU8 AL450380.2 Mycobrowser_v4 CDS 1885778 1886275 . + 0 ML1561 ML1561 conserved hypothetical protein ML1561, len: 165 aa. Conserved hypothetical protein. Highly similar to proteins of unknown function from Streptomyces coelicolor TR:CAB91137 (EMBL:AL355913) (167 aa), Fasta scores: E(): 1.4e-07, 35.8% identity in 137 aa overlap and Mycobacterium tuberculosis Rv2844 SW:O05815 (162 aa), fasta scores: E(): 6.2e-46, (71.515% identity in 165 aa overlap). Q7AQ41 No conserved hypotheticals Q7AQ41 Rv2844 Rv2844 AL450380.2 Mycobrowser_v4 CDS 1911381 1912181 . - 0 ML1585c ML1585c Probable conserved integral membrane protein (pseudogene) ML1585c, len: 801 bp. Possible pseudogene of M. tuberculosis orthologue Rv2877c (864 bp) (Best blastx scores: 174). Yes cell wall and cell processes Rv2877c Rv2877c AL450380.2 Mycobrowser_v4 CDS 1912800 1913349 . - 0 ML1587c ML1587c Conserved hypothetical protein (pseudogene) ML1587c, len: 550 bp. Possible pseudogene of M. tuberculosis orthologue Rv2879c (570 bp) (Best blastx scores: 272) Yes conserved hypotheticals Rv2879c Rv2879c AL450380.2 Mycobrowser_v4 CDS 1932278 1932601 . - 0 ML1606c ML1606c conserved hypothetical protein (pseudogene) ML1606c, len: 324 bp. Possible pseudogene of M. tuberculosis orthologue Rv2897c (1512 bp) (Best blastx scores: 361). Yes conserved hypotheticals Rv2897c Rv2897c AL450380.2 Mycobrowser_v4 CDS 1933139 1933670 . - 0 ML1608c fdhD Possible FdhD protein (pseudogene) ML1608c, len: 532 bp. Possible pseudogene of M. tuberculosis orthologue fdhD|Rv2899c (831 bp) (Best blastx scores: 188). Yes intermediary metabolism and respiration Rv2899c Rv2899c AL450380.2 Mycobrowser_v4 CDS 1952203 1953304 . - 0 ML1627c amt Probable ammonium transport integral membrane protein Amt (pseudogene) ML1627c, len: 1102 bp. Possible pseudogene of M. tuberculosis orthologue amt|Rv2920c (Best blastx scores: 233) Yes cell wall and cell processes Rv2920c Rv2920c AL450380.2 Mycobrowser_v4 CDS 1970380 1971820 . + 0 ML1636 ML1636 Conserved hypothetical protein (pseudogene) ML1636, len: 1441 bp. Possible pseudogene of M. tuberculosis orthologue Rv2226 (1542 bp) (Best blastx scores: 294). Yes conserved hypotheticals Rv2226 Rv2226 AL450380.2 Mycobrowser_v4 CDS 2128430 2128798 . + 0 ML1754 ML1754 PPE-family protein (pseudogene) ML1754, len: 369 bp. Possible pseudogene similar to numerous M. tuberculosis PPE-family proteins e.g. PPE19|Rv1361c, PPE2|Rv0256c, PPE48|Rv3022c, PPE11|Rv0453 and PPE37|Rv2123 (Best blastx scores: 134). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2197988 2198544 . + 0 ML1815 ML1815 Probable transcriptional regulatory protein (TetR/AcrR family) (pseudogene) ML1815, len: 557 bp. Possible pseudogene of M. tuberculosis orthologue Rv1474c (564 bp) (Best blastx scores: 442). Yes regulatory proteins Rv1474c Rv1474c AL450380.2 Mycobrowser_v4 CDS 2395011 2395792 . + 0 ML2002 fadB5 Possible oxidoreductase FadB5 (pseudogene) ML2002, len: 782 bp. Possible pseudogene of M. tuberculosis orthologue fadB5|Rv1912c (1005 bp) (Best blastx scores: 327). Yes lipid metabolism Rv1912c Rv1912c AL450380.2 Mycobrowser_v4 CDS 2865047 2865796 . - 0 ML2395c pra Probable Proline-rich antigen homolog Pra ML2395c, len: 249 aa. Probable pra, Proline-rich antigen homolog. Previously characterised Mycobacterium leprae proline-rich antigen Ag36 SW:PRA_MYCLE (P41484) (249 aa) fasta scores: E(): 0, 99.2% identity in 249 aa. Note the N-terminus of this protein is extremely rich in the amino acid Pro and contains a 3xGGSYPPPPP repeats. Contains possible membrane spanning hydrophobic domains. Previously known as Ag36. P41484 No cell wall and cell processes, conserved hypotheticals PF06271 P41484 Rv1078 Rv1078 AL450380.2 Mycobrowser_v4 CDS 1940003 1940245 . - 0 ML1617c ML1617c conserved hypothetical protein ML1617c, len: 80 aa. Conserved hypothetical protein. Highly similar to many proteins of undefined function e.g. Mycobacterium tuberculosis Rv2908c SW:YT08_MYCTU (Q10826) (80 aa), Fasta scores: E(): 6.5e-28, 93.8% identity in 80 aa overlap. Contains Pfam match to entry PF00013 KH-domain, KH domain. O33015 No conserved hypotheticals O33015 GO:0003723 Rv2908c Rv2908c AL450380.2 Mycobrowser_v4 CDS 2296436 2297130 . + 0 ML1913 echA3 Probable enoyl-CoA hydratase EchA3 (pseudogene) ML1913, len: 695 bp. Possible pseudogene of M. tuberculosis orthologue echA3|Rv0632c (696 bp) (Best blastx scores: 350). Yes lipid metabolism Rv0632c Rv0632c AL450380.2 Mycobrowser_v4 CDS 2299923 2300397 . + 0 ML1916 ML1916 Conserved hypothetical protein (pseudogene) ML1916, len: 475 bp. Possible pseudogene of M. tuberculosis orthologue Rv0580c (492 bp) (Best blastx scores: 335). Yes conserved hypotheticals Rv0580c Rv0580c AL450380.2 Mycobrowser_v4 CDS 2368114 2369142 . - 0 ML1984c ML1984c Possible monooxygenase (pseudogene) ML1984c, len: 1029 bp. Possible pseudogene similar to M. tuberculosis Rv3618 (1188 bp) (Best blastx scores: 108). Also similar to ML0220c a possible pseudogene similar to M. tuberculosis Rv3618. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2443630 2444722 . - 0 ML2056c modC Probable molybdenum-transport ATP-binding protein ABC transporter ModC (pseudogene) ML2056c, len: 1093 bp. Possible pseudogene of M. tuberculosis orthologue modC|Rv1859 (1110 bp) (Best blastx scores: 272). Yes cell wall and cell processes Rv1859 Rv1859 AL450380.2 Mycobrowser_v4 CDS 2493325 2494406 . + 0 ML2097 ML2097 Conserved hypothetical protein (pseudogene) ML2097, len: 1082 bp. Possible pseudogene of M. tuberculosis orthologue Rv0926c (1077 bp) (Best blastx scores: 224). Yes conserved hypotheticals Rv0926c Rv0926c AL450380.2 Mycobrowser_v4 CDS 2574012 2574275 . - 0 ML2164c ML2164c Conserved hypothetical protein (pseudogene) ML2164c, len: 264 bp. Possible pseudogene of M. tuberculosis orthologue Rv0857 (474 bp) (Best blastx scores: 152). Yes conserved hypotheticals Rv0857 Rv0857 AL450380.2 Mycobrowser_v4 CDS 2140727 2141749 . - 0 ML1766c ML1766c Conserved hypothetical protein (pseudogene) ML1766c, len: 1023 bp. Possible pseudogene of M. tuberculosis orthologue Rv2314c (1374 bp) (Best blastx scores: 286). Yes conserved hypotheticals Rv2314c Rv2314c AL450380.2 Mycobrowser_v4 CDS 2634538 2634781 . - 0 ML2216c ML2216c Probable oxidoreductase (pseudogene) ML2216c, len: 244 bp. Possible pseudogene of M. tuberculosis orthologue Rv0794c (1500 bp) (Best blastx scores: 153). Yes intermediary metabolism and respiration Rv0794c Rv0794c AL450380.2 Mycobrowser_v4 CDS 2634761 2635293 . + 0 ML2217 ML2217 Hypothetical protein (pseudogene) ML2217, len: 533 bp. Possible pseudogene of M. tuberculosis orthologue Rv0790c (729 bp) (Best blastx scores: 295). Yes conserved hypotheticals Rv0790c Rv0790c AL450380.2 Mycobrowser_v4 CDS 2705542 2706682 . - 0 ML2281c ML2281c Probable monooxygenase (pseudogene) ML2281c, len: 1141 bp. Possible pseudogene of M. tuberculosis orthologue Rv0565c (1461 bp) (Best blastx scores: 482). Yes intermediary metabolism and respiration Rv0565c Rv0565c AL450380.2 Mycobrowser_v4 CDS 2825333 2825957 . - 0 ML2360c ML2360c Hypothetical protein (pseudogene) ML2360c, len: 625 bp. Possible pseudogene of M. tuberculosis orthologue Rv3766 (690 bp) (Best blastx scores: 165). Yes conserved hypotheticals Rv3766 Rv3766 AL450380.2 Mycobrowser_v4 CDS 2840038 2840641 . - 0 ML2371c ML2371c Possible conserved transmembrane protein (pseudogene) ML2371c, len: 604 bp. Possible pseudogene of M. tuberculosis orthologue Rv0446c (771 bp) (Best blastx scores: 144). Yes cell wall and cell processes Rv0446c Rv0446c AL450380.2 Mycobrowser_v4 CDS 2235755 2236036 . - 0 ML1852c ML1852c Probable conserved transmembrane protein (pseudogene) ML1852c, len: 282 bp. Possible pseudogene of M. tuberculosis orthologue Rv0713 (942 bp) (Best blastx scores: 194). Yes cell wall and cell processes Rv0713 Rv0713 AL450380.2 Mycobrowser_v4 CDS 2712443 2712667 . - 0 ML2288c ML2288c hypothetical protein ML2288c, len: 74 aa. Hypothetical protein. Q9CBA0 No unknown Q9CBA0 AL450380.2 Mycobrowser_v4 CDS 2739928 2740518 . + 0 ML2312 ML2312 POSSIBLE CONSERVED MEMBRANE PROTEIN ML2312, len: 196 aa. Possible conserved membrane protein. Similar to the C-terminus of Mycobacterium tuberculosis hypothetical protein Rv3695 TR:O69663 (EMBL:AL022121) (310 aa) fasta scores: E(): 0, 71.1% identity in 190 aa and Streptomyces coelicolor putative integral membrane protein TR:CAB88905 (EMBL:AL353862) (318 aa) fasta scores: E(): 2e-15, 39.5% identity in 190 aa. Contains a possible membrane spanning hydrophobic domain Q9CB83 No cell wall and cell processes PF06271 Q9CB83 Rv3695 Rv3695 AL450380.2 Mycobrowser_v4 CDS 1924410 1924751 . + 0 ML1599 ML1599 Conserved hypothetical protein (pseudogene) ML1599, len: 342 bp. Possible pseudogene of M. tuberculosis orthologue Rv2891 (750 bp) (Best blastx scores: 96). Yes conserved hypotheticals Rv2891 Rv2891 AL450380.2 Mycobrowser_v4 CDS 1983846 1984139 . - 0 ML1646c ML1646c Hypothetical protein (pseudogene) ML1646c, len: 294 bp. Possible pseudogene of M. tuberculosis orthologue Rv1045 (882 bp) (Best blastx scores: 116). Yes conserved hypotheticals Rv1045 Rv1045 AL450380.2 Mycobrowser_v4 CDS 1984409 1984869 . - 0 ML1647c ML1647c Conserved hypothetical protein (pseudogene) ML1647c, len: 461 bp. Possible pseudogene of M. tuberculosis orthologue Rv1044 (624 bp) (Best blastx scores: 117). Yes conserved hypotheticals Rv1044 Rv1044 AL450380.2 Mycobrowser_v4 CDS 2883438 2884106 . - 0 ML2412c ML2412c POSSIBLE THIOREDOXIN PROTEIN (THIOL-DISULFIDE INTERCHANGE PROTEIN) ML2412c, len: 222 aa. Possible thioredoxin protein (thiol-disulfide interchange protein). Similar to Mycobacterium tuberculosis thioredoxin protein Rv0526 TR:O06392 (EMBL:Z95558) (216 aa) fasta scores: E(): 0, 78.5% identity in 214 aa. Q9CB61 No intermediary metabolism and respiration PF00578 Q9CB61 GO:0045454,GO:0016491,GO:0016209 Rv0526 Rv0526 AL450380.2 Mycobrowser_v4 CDS 2292375 2292815 . - 0 ML1907c secE PROBABLE PREPROTEIN TRANSLOCASE SECE ML1907c, len: 146 aa. Probable secE, preprotein translocase. Similar to M. tuberculosis preprotein translocase SecE subunit Rv0638 SW:SECE_MYCTU (P96929) (161 aa), Fasta scores: E(): 2.2e-19, 61.3% identity in 160 aa overlap, and to many others e.g. Streptomyces virginiae SW:SECE_STRvG (P36691) (93 aa), Fasta scores: E(): 7.9e-08, 41.0% identity in 78 aa overlap. Contains Pfam match to entry PF00584 SecE, SecE/Sec61-gamma subunits of protein translocation complex. Contains PS01067 Protein secE/sec61-gamma signature. Q9CBJ9 No cell wall and cell processes PF00584 Q9CBJ9 GO:0016021,GO:0065002,GO:0005886,GO:0009306,GO:0006605,GO:0015450 Rv0638 Rv0638 AL450380.2 Mycobrowser_v4 CDS 2876297 2876749 . - 0 ML2404c galE3 Possible UDP-glucose 4-epimerase GalE3 (pseudogene) ML2404c, len: 453 bp. Possible pseudogene of M. tuberculosis orthologue galE3|Rv0536 (1041 bp) (Best blastx scores: 316). Yes intermediary metabolism and respiration Rv0536 Rv0536 AL450380.2 Mycobrowser_v4 CDS 1979765 1980683 . - 0 ML1645c cobD Probable cobalamin biosynthesis transmembrane protein CobD (pseudogene) ML1645c, len: 919 bp. Possible pseudogene of M. tuberculosis orthologue cobD|Rv2236c (942 bp) (Best blastx scores: 204). Yes intermediary metabolism and respiration Rv2236c Rv2236c AL450380.2 Mycobrowser_v4 CDS 2046586 2046950 . + 0 ML1697 cfp6 Low molecular weight protein antigen 6 Cfp6 (pseudogene) ML1697, len: 365 bp. Possible pseudogene of M. tuberculosis orthologue Rv3004|cfp6 (339 bp) (Best blastx scores: 93). Yes cell wall and cell processes Rv3004 Rv3004 AL450380.2 Mycobrowser_v4 CDS 2063024 2063721 . - 0 ML1710c ML1710c Conserved hypothetical protein (pseudogene) ML1710c, len: 698 bp. Possible pseudogene of M. tuberculosis orthologue Rv3027c (741 bp) (Best blastx scores: 295). Yes intermediary metabolism and respiration Rv3027c Rv3027c AL450380.2 Mycobrowser_v4 CDS 2141845 2143220 . - 0 ML1767c ML1767c Conserved hypothetical protein (pseudogene) ML1767c, len: 1376 bp. Possible pseudogene of M. tuberculosis orthologue Rv2315c (1518 bp) (Best blastx scores: 309). Yes conserved hypotheticals Rv2315c Rv2315c AL450380.2 Mycobrowser_v4 CDS 2297466 2297949 . + 0 ML1914 lpqN Probable conserved lipoprotein LpqN (pseudogene) ML1914, len: 484 bp. Possible pseudogene of M. tuberculosis orthologue lpqN|Rv0583c (687 bp) (Best blastx scores: 198). Yes cell wall and cell processes Rv0583c Rv0583c AL450380.2 Mycobrowser_v4 CDS 2001614 2002267 . - 0 ML1660c ML1660c conserved hypothetical protein ML1660c, len: 217 aa. Conserved hypothetical protein. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2926c TR:YT26_MYCTU (207 aa), fasta scores: E(): 6.5e-53, (67.188% identity in 192 aa overlap). O69468 No conserved hypotheticals PF02620 O69468 Rv2926c Rv2926c AL450380.2 Mycobrowser_v4 CDS 1978482 1978965 . + 0 ML1643 ptpA Probable low molecular weight protein-tyrosine-phosphatase PtpA (pseudogene) ML1643, len: 484 bp. Possible pseudogene of M. tuberculosis orthologue ptpA|Rv2234 (492 bp) (Best blastx scores: 453). Yes regulatory proteins Rv2234 Rv2234 AL450380.2 Mycobrowser_v4 CDS 2552018 2552428 . - 0 ML2147c cspB PROBABLE COLD SHOCK-LIKE PROTEIN B CSPB ML2147c, len: 136 aa. Probable cspB, cold shock-like protein. Similar to Mycobacterium tuberculosis cold shock protein b Rv0871 TR:O53883 (EMBL:AL022004) fasta scores: E(): 0, 86.0% in 136 aa, and to Bacillus cereus cold shock-like protein cspc SW:CSPC_BACCE (Q45098) fasta scores: E(): 5.2e-08, 54.4% in 57 aa. Also similar to ML0198 from M. leprae. Contains Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain. O33052 No virulence, detoxification, adaptation PF00313 O33052 GO:0005737,GO:0006355,GO:0003677 Rv0871 Rv0871 AL450380.2 Mycobrowser_v4 CDS 2329153 2329897 . - 0 ML1943c ML1943c Conserved hypothetical protein (pseudogene) ML1943c, len: 745 bp. Possible pseudogene similar to M. tuberculosis Rv3714c (891 bp) (Best blastx scores: 199). Identical to ML1047c and similar to ML2328c possible pseudogenes similar to M. tuberculosis Rv3714c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2366098 2366467 . + 0 ML1981 ML1981 Hypothetical protein (pseudogene) ML1981, len: 370 bp. Possible pseudogene of M. tuberculosis orthologue Rv1924c (381 bp) (Best blastx scores: 169). Yes conserved hypotheticals Rv1924c Rv1924c AL450380.2 Mycobrowser_v4 CDS 2399865 2400347 . + 0 ML2007 ML2007 Hypothetical protein (pseudogene) ML2007, len: 483 bp. Possible pseudogene of M. tuberculosis orthologue Rv1907c (648 bp) (Best blastx scores: 281). Yes conserved hypotheticals Rv1907c Rv1907c AL450380.2 Mycobrowser_v4 CDS 2514737 2516708 . - 0 ML2115c ctpE Probable metal cation transport ATPase P-type CtpE (pseudogene) ML2115c, len: 1972 bp. Possible pseudogene of M. tuberculosis orthologue ctpE|Rv0908 (2394 bp) (Best blastx scores: 568). Yes cell wall and cell processes Rv0908 Rv0908 AL450380.2 Mycobrowser_v4 CDS 2516705 2517567 . - 0 ML2116c ML2116c Conserved hypothetical protein (pseudogene) ML2116c, len: 863 bp. Possible pseudogene of M. tuberculosis orthologue Rv0907 (1599 bp) (Best blastx scores: 178). Yes cell wall and cell processes Rv0907 Rv0907 AL450380.2 Mycobrowser_v4 CDS 2552602 2552952 . + 0 ML2148 ML2148 Possible conserved integral membrane protein (pseudogene) ML2148, len: 351 bp. Possible pseudogene of M. tuberculosis orthologue Rv0870c (390 bp) (Best blastx scores: 300). Yes cell wall and cell processes Rv0870c Rv0870c AL450380.2 Mycobrowser_v4 CDS 2553111 2554048 . + 0 ML2149 moaA2 Probable molybdenum cofactor biosynthesis protein A MoaA2 (pseudogene) ML2149, len: 938 bp. Possible pseudogene of M. tuberculosis orthologue moaA2|Rv0869c (1083 bp) (Best blastx scores: 272). Yes intermediary metabolism and respiration Rv0869c Rv0869c AL450380.2 Mycobrowser_v4 CDS 2518777 2519520 . - 0 ML2118c echA6 POSSIBLE ENOYL-CoA HYDRATASE ECHA6 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) ML2118c, len: 247 aa. Possible echA6, enoyl-CoA hydratase (EC 4.2.1.17). Similar to Mycobacterium tuberculosis probable enoyl-coa hydratase echa6|Rv0905 SW:ECH6_MYCTU (Q10533) fasta scores: E(): 0, 85.8% in 247 aa, and to Escherichia coli probable enoyl-coa hydratase paaf SW:PAAF_ECOLI (P76082; P78288; O53014) fasta scores: E(): 3.1e-18, 32.1% in 252 aa. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Q50130 No lipid metabolism PF00378 Q50130 GO:0006631,GO:0004300 4.2.1.17 Rv0905 Rv0905 AL450380.2 Mycobrowser_v4 CDS 2006198 2009582 . - 0 ML1665c pca Probable pyruvate carboxylase Pca (pseudogene) ML1665c, len: 3385 bp. Possible pseudogene of M. tuberculosis orthologue pca|Rv2967c (3384 bp) (Best blastx scores: 873). Yes intermediary metabolism and respiration Rv2967c Rv2967c AL450380.2 Mycobrowser_v4 CDS 2032706 2032837 . + 0 ML1687 ML1687 Conserved hypothetical protein (pseudogene) ML1687, len: 132 bp. Possible pseudogene of M. tuberculosis orthologue Rv2991 (492 bp) (Best blastx scores: 154). Yes conserved hypotheticals Rv2991 Rv2991 AL450380.2 Mycobrowser_v4 CDS 2097654 2098166 . - 0 ML1737c ML1737c Conserved hypothetical protein (pseudogene) ML1737c, len: 513 bp. Possible pseudogene of M. tuberculosis orthologue Rv3054c (555 bp) (Best blastx scores: 267). Yes conserved hypotheticals Rv3054c Rv3054c AL450380.2 Mycobrowser_v4 CDS 2098329 2098918 . + 0 ML1738 ML1738 Possible transcriptional regulatory protein (probably tetR-family (pseudogene) ML1738, len: 590 bp. Possible pseudogene of M. tuberculosis orthologue Rv3055 (615 bp) (Best blastx scores: 428). Yes regulatory proteins Rv3055 Rv3055 AL450380.2 Mycobrowser_v4 CDS 2131618 2132174 . + 0 ML1757 ML1757 Probable transcriptional regulatory protein (deoR-family) (pseudogene) ML1757, len: 557 bp. Possible pseudogene of M. tuberculosis orthologue Rv3066 (609 bp) (Best blastx scores: 163). Yes regulatory proteins Rv3066 Rv3066 AL450380.2 Mycobrowser_v4 CDS 2132593 2132936 . - 0 ML1758c ML1758c Probable oxidoreductase (pseudogene) ML1758c, len: 344 bp. Possible pseudogene similar to M. tuberculosis Rv2776c (930 bp) (Best blastx scores: 219). Also similar to ML1529c a possible pseudogene similar to M. tuberculosis Rv2776c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2313265 2313670 . + 0 ML1930 ML1930 Hypothetical protein (pseudogene) ML1930, len: 406 bp. Possible pseudogene of M. tuberculosis orthologue Rv0428c (909 bp) (Best blastx scores: 239). Yes intermediary metabolism and respiration Rv0428c Rv0428c AL450380.2 Mycobrowser_v4 CDS 2330871 2331244 . - 0 ML1944c ML1944c possible IS1081 transposase (pseudogene) ML1944c, len: 374 bp. Possible pseudogene similar to several IS1081 transposases (Best blastx scores: 63) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2348132 2348287 . + 0 ML1963 ML1963 Conserved hypothetical protein (pseudogene) ML1963, len: 156 bp. Possible pseudogene of M. tuberculosis orthologue Rv3463 (858 bp) (Best blastx scores: 121). Yes conserved hypotheticals Rv3463 Rv3463 AL450380.2 Mycobrowser_v4 CDS 2365106 2365902 . - 0 ML1980c fadD31 Probable acyl-CoA synthetase FadD31 (pseudogene) ML1980c, len: 797 bp. Possible pseudogene of M. tuberculosis orthologue fadD31|Rv1925 (1863 bp) (Best blastx scores: 214). Yes lipid metabolism Rv1925 Rv1925 AL450380.2 Mycobrowser_v4 CDS 2540848 2541045 . - 0 ML2138c ML2138c Probable transmembrane protein (pseudogene) ML2138c, len: 198 bp. Possible pseudogene of M. tuberculosis orthologue Rv0882 (285 bp) (Best blastx scores: 124). Yes cell wall and cell processes Rv0882 Rv0882 AL450380.2 Mycobrowser_v4 CDS 2541157 2541956 . - 0 ML2139c ML2139c Possible rRNA methyltransferase (pseudogene) ML2139c, len: 800 bp. Possible pseudogene of M. tuberculosis orthologue Rv0881 (867 bp) (Best blastx scores: 255). Yes intermediary metabolism and respiration Rv0881 Rv0881 AL450380.2 Mycobrowser_v4 CDS 2568750 2569069 . + 0 ML2160 ML2160 Probable oxidoreductase (pseudogene) ML2160, len: 320 bp. Possible pseudogene similar to M. tuberculosis Rv1260 (1119 bp) (Best blastx scores: 80). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2577728 2578742 . - 0 ML2168c fadD16 Possible fatty-acid-CoA ligase FadD16 (pseudogene) ML2168c, len: 1015 bp. Possible pseudogene of M. tuberculosis orthologue fadD16|Rv0852 (837 bp) (Best blastx scores: 254). Yes lipid metabolism Rv0852 Rv0852 AL450380.2 Mycobrowser_v4 CDS 2581288 2582685 . + 0 ML2171 ML2171 Probable oxidase (pseudogene) ML2171, len: 1398 bp. Possible pseudogene of M. tuberculosis orthologue Rv0846c (1515 bp) (Best blastx scores: 209). Yes intermediary metabolism and respiration Rv0846c Rv0846c AL450380.2 Mycobrowser_v4 CDS 2602119 2603522 . + 0 ML2187 ML2187 Conserved hypothetical protein (pseudogene) ML2187, len: 1404 bp. Possible pseudogene of M. tuberculosis orthologue Rv0822c (2055 bp) (Best blastx scores: 723). Yes conserved hypotheticals Rv0822c Rv0822c AL450380.2 Mycobrowser_v4 CDS 2325746 2326363 . + 0 ML1939 ML1939 conserved hypothetical protein ML1939, len: 205 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv1109c. Q7AQ17 No conserved hypotheticals Q7AQ17 Rv1109c Rv1109c AL450380.2 Mycobrowser_v4 CDS 2784600 2785371 . - 0 ML2344c ML2344c Probable conserved integral membrane transport protein (pseudogene) ML2344c, len: 772 bp. Possible pseudogene similar to M. tuberculosis Rv1200 (1278 bp) (Best blastx scores: 189). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2826438 2827088 . + 0 ML2361 tcrX Probable two-component transcriptional regulatory protein TcrX (pseudogene) ML2361, len: 651 bp. Possible pseudogene of M. tuberculosis orthologue Rv3765c|tcrX (705 bp) (Best blastx scores: 195). Yes regulatory proteins Rv3765c Rv3765c AL450380.2 Mycobrowser_v4 CDS 2234751 2235617 . - 0 ML1851c ML1851c Conserved hypothetical protein (pseudogene) ML1851c, len: 867 bp. Possible pseudogene of M. tuberculosis orthologue Rv0712 (900 bp) (Best blastx scores: 304). Yes conserved hypotheticals Rv0712 Rv0712 AL450380.2 Mycobrowser_v4 CDS 2283641 2284555 . + 0 ML1899 lipG PROBABLE LIPASE/ESTERASE LIPG ML1899, len: 304 aa. probable lipG, lipase/esterase (EC 3.1.-.-). Similar to M. tuberculosis putative hydrolase Rv0646c TR:P96935 (EMBL:Z92772) (301 aa), Fasta scores: E(): 0, 71.3% identity in 303 aa overlap, and to others e.g. Escherichia coli macrolide 2'-phosphotransferase II TR:P77026 (EMBL:D85892) (279 aa), Fasta scores: E(): 1.3e-15, 31.3% identity in 291 aa overlap, and Streptomyces peucetius 10-carbomethoxy-13-deoxycarminomycin esterase TR:Q54809 (EMBL:L40425) (298 aa), Fasta scores: E(): 1e-09, 28.6% identity in 301 aa overlap. Also similar to ML0862 from M. leprae. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Q9CBK5 No intermediary metabolism and respiration PF00561 Q9CBK5 GO:0016787 Rv0646c Rv0646c AL450380.2 Mycobrowser_v4 CDS 2636683 2636922 . - 0 ML2219A ML2219A conserved hypothetical protein ML2219A, len: 79 aa. Conserved hypothetical protein. Similar to M. tuberculosis Rv0787A Conserved hypothetical protein (79 aa) fasta scores: E(): 4.7e-27, (84.810% identity in 79 aa overlap). Similar to various hypothetical proteins e.g. Streptomyces coelicolor hypothetical protein Q9RKK7 Hypothetical protein SCO4077 (90 aa), fasta scores: E(): 3.6e-18, (68.293% identity in 82 aa overlap). No conserved hypotheticals Rv0787A Rv0787A AL450380.2 Mycobrowser_v4 CDS 2244678 2245156 . - 0 ML1865c ML1865c PE-family protein (pseudogene) ML1865c, len: 479 bp. Possible pseudogene similar to M. tuberculosis PE-family proteins e.g. PE16|Rv1430, PE3|Rv0159c and PE4|Rv0160c (Best blastx scores: 125). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2281688 2281959 . - 0 ML1897c ML1897c Possible sugar kinase (pseudogene) ML1897c, len: 272 bp. Possible pseudogene of M. tuberculosis orthologue Rv0650 (909 bp)(Best blastx scores: 139). Yes intermediary metabolism and respiration Rv0650 Rv0650 AL450380.2 Mycobrowser_v4 CDS 2285632 2286499 . + 0 ML1901 mmaA2 Methoxy mycolic acid synthase 2 MmaA2 (pseudogene) ML1901, len: 868 bp. Possible pseudogene of M. tuberculosis orthologue mmaA2|Rv0644c (864 bp) (Best blastx scores: 452). Yes lipid metabolism Rv0644c Rv0644c AL450380.2 Mycobrowser_v4 CDS 2415028 2416234 . + 0 ML2024 cyp125 Probable cytochrome p450 125 Cyp125 (pseudogene) ML2024, len: 1207 bp. Possible pseudogene similar to M. tuberculosis Rv3545c|cyp125 (1302 bp) (Best blastx scores: 411) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2469901 2470592 . - 0 ML2078c ML2078c Conserved hypothetical protein (pseudogene) ML2078c, len: 692 bp. Possible pseudogene of M. tuberculosis orthologue Rv1825 (879 bp) (Best blastx scores: 286). Yes conserved hypotheticals Rv1825 Rv1825 AL450380.2 Mycobrowser_v4 CDS 2548830 2550699 . - 0 ML2146c fadE10 Probable acyl-CoA dehydrogenase FadE10 (pseudogene) ML2146c, len: 1870 bp. Possible pseudogene of M. tuberculosis orthologue fadE10|Rv0873 (1953 bp) (Best blastx scores: 502). Yes lipid metabolism Rv0873 Rv0873 AL450380.2 Mycobrowser_v4 CDS 2595838 2596418 . - 0 ML2181c ML2181c conserved hypothetical protein (pseudogene) ML2181c, len: 581 bp. Possible pseudogene of M. tuberculosis orthologue Rv0830 (906 bp) (Best blastx scores: 192). Yes lipid metabolism Rv0830 Rv0830 AL450380.2 Mycobrowser_v4 CDS 2616775 2617645 . - 0 ML2202c ML2202c Probable amino acid aminotransferase (pseudogene) ML2202c, len: 871 bp. Possible pseudogene of M. tuberculosis orthologue Rv0812 (870 bp) (Best blastx scores: 299). Yes intermediary metabolism and respiration Rv0812 Rv0812 AL450380.2 Mycobrowser_v4 CDS 2622752 2623866 . + 0 ML2208 ML2208 Mce-family protein (pseudogene) ML2208, len: 1115 bp. Possible pseudogene similar to several M. tuberculosis Mce proteins e.g. mce2A|Rv0589 and mce1A|Rv0169 (Best blastx scores: 226). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2646621 2647490 . - 0 ML2229c cyp126 Possible cytochrome P450 126 Cyp126 (pseudogene) ML2229c, len: 870 bp. Possible pseudogene of M. tuberculosis orthologue Rv0778|cyp126 (1245 bp) (Best blastx scores: 305). Yes intermediary metabolism and respiration Rv0778 Rv0778 AL450380.2 Mycobrowser_v4 CDS 2680331 2681328 . - 0 ML2256c ML2256c Probable conserved integral membrane protein (pseudogene) ML2256c, len: 998 bp. Possible pseudogene of M. tuberculosis orthologue Rv0541c (1350 bp) (Best blastx scores: 212). Yes cell wall and cell processes Rv0541c Rv0541c AL450380.2 Mycobrowser_v4 CDS 2253886 2254576 . - 0 ML1875c ML1875c Probable short-chain dehydrogenase/reductase (pseudogene) ML1875c, len: 691 bp. Possible pseudogene of M. tuberculosis orthologue Rv0687 (828 bp) (Best blastx scores: 122). Yes intermediary metabolism and respiration Rv0687 Rv0687 AL450380.2 Mycobrowser_v4 CDS 2254850 2255518 . - 0 ML1876c ML1876c Probable membrane protein (pseudogene) ML1876c, len: 669 bp. Possible pseudogene of M. tuberculosis orthologue Rv0686 (798 bp) (Best blastx scores: 157). Yes cell wall and cell processes Rv0686 Rv0686 AL450380.2 Mycobrowser_v4 CDS 2672727 2673044 . - 0 ML2249c ML2249c hypothetical protein ML2249c, len: 105 aa. Hypothetical unknown protein. Q9CBB9 No unknown Q9CBB9 AL450380.2 Mycobrowser_v4 CDS 2735800 2736727 . + 0 ML2310 ML2310 Probable lyase, cysteine metabolism (pseudogene) ML2310, len: 928 bp. Possible pseudogene of M. tuberculosis orthologue Rv3684 (1041 bp) (Best blastx scores: 298). Yes intermediary metabolism and respiration Rv3684 Rv3684 AL450380.2 Mycobrowser_v4 CDS 2439167 2440115 . + 0 ML2050 ML2050 Probable reductase (pseudogene) ML2050, len: 949 bp. Possible pseudogene of M. tuberculosis orthologue Rv1869c (1236 bp) (Best blastx scores: 450). Yes intermediary metabolism and respiration Rv1869c Rv1869c AL450380.2 Mycobrowser_v4 CDS 2781969 2782724 . - 0 ML2342c ML2342c Conserved hypothetical protein (pseudogene) ML2342c, len: 756 bp. Possible pseudogene of M. tuberculosis orthologue Rv3730c (1041 bp) (Best blastx scores: 278) Yes conserved hypotheticals Rv3730c Rv3730c AL450380.2 Mycobrowser_v4 CDS 2851047 2851927 . - 0 ML2381c echA2 Enoyl-CoA hydratase EchA2 (pseudogene) ML2381c, len: 881 bp. Possible pseudogene of M. tuberculosis orthologue echA2|Rv0456c (915 bp) (Best blastx scores: 203). Yes lipid metabolism Rv0456c Rv0456c AL450380.2 Mycobrowser_v4 CDS 2295531 2296247 . + 0 ML1912 ML1912 POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II) ML1912, len: 238 aa. Possible glyoxylase II (EC 3.1.2.6). Similar to M. tuberculosis putative glyoxylase II Rv0634c, to hypothetical proteins belonging to the glyoxalase II family e.g. Escherichia coli SW:YCBL_ECOLI (P75849) (215 aa), Fasta scores: E(): 3.5e-12, 32.5% identity in 203 aa overlap. Also similar to ML0493, ML2303 and ML1391 from M. leprae. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Q9CBJ4 No virulence, detoxification, adaptation PF00753 Q9CBJ4 GO:0016787 Rv0634c Rv0634c AL450380.2 Mycobrowser_v4 CDS 1937826 1938729 . + 0 ML1614 lppW Probable conserved alanine rich lipoprotein LppW (pseudogene) ML1614, len: 904 bp. Possible pseudogene of M. tuberculosis orthologue lppW|Rv2905 (945 bp) (Best blastx scores: 203). Yes cell wall and cell processes Rv2905 Rv2905 AL450380.2 Mycobrowser_v4 CDS 1935027 1935332 . - 0 ML1610c ML1610c conserved hypothetical protein ML1610c, len: 101 aa. Conserved hypothetical protein. Similar to several proteins of unknown function from Mycobacterium tuberculosis e.g. Rv2901c SW:YT01_MYCTU (Q10822) (101 aa), Fasta scores: E(): 0, 99.0% identity in 101 aa overlap. Q7AQ38 No conserved hypotheticals PF10611 Q7AQ38 Rv2901c Rv2901c AL450380.2 Mycobrowser_v4 CDS 2205037 2205312 . - 0 ML1821A ML1821A conserved hypothetical protein ML1821A, len: 92 aa. Conserved hypothetical protein. Similar to the N-terminal region of Q8GE87 Hypothetical protein from M. avium (186 aa), fasta scores: E(): 9.4e-13, (47.312% identity in 93 aa overlap). Homology to Q8GE87 continues upstream of this ORF in a different frame suggesting a possible frameshift. No conserved hypotheticals AL450380.2 Mycobrowser_v4 CDS 1932707 1932997 . - 0 ML1607c ML1607c conserved hypothetical protein ML1607c, len: 96 aa. Conserved hypothetical protein. Similar to N terminus of Mycobacterium tuberculosis hypothetical protein Rv2898c SW:YS98_MYCTU (Q10819) (128 aa), Fasta scores: E(): 7.9e-19, 58.3% identity in 96 aa overlap. Contains Pfam match to entry PF02021 UPF0102, Uncharacterised protein family UPF0102. O33024 No conserved hypotheticals PF02021 O33024 Rv2898c Rv2898c AL450380.2 Mycobrowser_v4 CDS 2361841 2362418 . + 0 ML1977 ML1977 Possible conserved membrane protein (pseudogene) ML1977, len: 578 bp. Possible pseudogene similar to M. tuberculosis Rv2025c (999 bp) (Best blastx scores: 209). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1938746 1939462 . - 0 ML1615c trmD PROBABLE TRNA (GUANINE-N1)-METHYLTRANSFERASE TRMD (M1G-METHYLTRANSFERASE) (TRNA [GM37] METHYLTRANSFERASE) ML1615c, len: 238 aa. Probable trmD, tRNA (guanine-N1)-methyltransferase (EC 2.1.1.31). Highly similar to many tRNA (guanine-N1) methyltransferases including: Escherichia coli SW:TRMD_ECOLI (P07020) (255 aa), Fasta scores: E(): 5.4e-33, 43.5% identity in 230 aa overlap and Mycobacterium tuberculosis Rv2906c SW:TRMD_MYCTU (Q10797) (230 aa), Fasta scores: E(): 0, 87.7% identity in 227 aa overlap. Contains Pfam match to entry PF01746 tRNA_m1G_MT, tRNA (Guanine-1)-methyltransferase. O33017 No information pathways PF01746 O33017 GO:0005737,GO:0009019,GO:0006400,GO:0003723 2.1.1.31 Rv2906c Rv2906c AL450380.2 Mycobrowser_v4 CDS 2214820 2215197 . + 0 ML1829 ML1829 hypothetical protein ML1829, len: 125 aa. Hypothetical unknown protein. Q9CBK9 No unknown Q9CBK9 AL450380.2 Mycobrowser_v4 CDS 1947644 1949434 . + 0 ML1624 ML1624 conserved hypothetical protein ML1624, len: 596 aa. Conserved hypothetical protein. Highly similar to several proteins of unknown function including: Mycobacterium tuberculosis Rv2917 SW:YT17_MYCTU (Q10966) (626 aa), Fasta scores: E(): 0, 79.8% identity in 584 aa overlap and Streptomyces coelicolor TR:Q9S3Y6 (EMBL:AF170560) (597 aa), Fasta scores: E(): 0, 55.5% identity in 566 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O33011 No conserved hypotheticals PF04851 O33011 GO:0003677,GO:0004386,GO:0005524 Rv2917 Rv2917 AL450380.2 Mycobrowser_v4 CDS 1977066 1978059 . - 0 ML1640c cobC Possible aminotransferase CobC (pseudogene) ML1640c, len: 994 bp. Possible pseudogene of M. tuberculosis orthologue cobC|Rv2231c (1095 bp) (Best blastx scores: 299). Yes intermediary metabolism and respiration Rv2231c Rv2231c AL450380.2 Mycobrowser_v4 CDS 1978112 1978453 . + 0 ML1641 ML1641 conserved hypothetical protein (pseudogene) ML1641, len: 342 bp. Possible pseudogene of M. tuberculosis orthologue Rv2232 (876 bp) (Best blastx scores: 218). Yes regulatory proteins Rv2232 Rv2232 AL450380.2 Mycobrowser_v4 CDS 1987836 1988258 . - 0 ML1649c ML1649c conserved hypothetical protein ML1649c, len: 140 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2239c SW:YM39_MYCTU (Q10521) (158 aa), Fasta scores: E(): 0, 86.4% identity in 140 aa overlap. Q7AQ35 No conserved hypotheticals Q7AQ35 Rv2239c Rv2239c AL450380.2 Mycobrowser_v4 CDS 1978968 1979780 . + 0 ML1644 ML1644 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML1644, len: 270 aa. Probable conserved transmembrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2235 SW:YM35_MYCTU (Q10517) (271 aa), Fasta scores: E(): 0, 74.2% identity in 271 aa overlap. Contains a possible N-terminal signal sequence and another possible membrane spanning hydrophobic domain. Q7AQ36 No cell wall and cell processes Q7AQ36 Rv2235 Rv2235 AL450380.2 Mycobrowser_v4 CDS 2002301 2003044 . - 0 ML1661c ML1661c conserved hypothetical protein ML1661c, len: 247 aa. Conserved hypothetical protein. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2927c TR:YT27_MYCTU (245 aa), fasta scores: E(): 6.7e-80, (90.204% identity in 245 aa overlap). Q9CBS6 No conserved hypotheticals Q9CBS6 Rv2927c Rv2927c AL450380.2 Mycobrowser_v4 CDS 2010261 2011055 . - 0 ML1667c ML1667c POSSIBLE CONSERVED MEMBRANE OR SECRETED PROTEIN ML1667c, len: 264 aa. Possible conserved membrane or secreted protein. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2969c TR:O33272 (EMBL:Z83018) (255 aa), Fasta scores: E(): 0, 65.5% identity in 258 aa overlap. Contains a possible membrane spanning hydrophobic domain. Q9CBS4 No cell wall and cell processes Q9CBS4 Rv2969c Rv2969c AL450380.2 Mycobrowser_v4 CDS 2013982 2014639 . - 0 ML1670c ML1670c Possible conserved membrane or exported protein (pseudogene) ML1670c, len: 658 bp. Possible pseudogene of M. tuberculosis orthologue Rv2972c (714 bp) (Best blastx scores: 445). Yes cell wall and cell processes Rv2972c Rv2972c AL450380.2 Mycobrowser_v4 CDS 2018449 2018649 . - 0 ML1673c ML1673c Conserved hypothetical protein (pseudogene) ML1673c, len: 201 bp. Possible pseudogene of M. tuberculosis orthologue Rv2975c (255 bp) (Best blastx scores: 88.) Yes conserved hypotheticals Rv2975c Rv2975c AL450380.2 Mycobrowser_v4 CDS 2018913 2019179 . + 0 ML1674 ML1674 50S ribosomal protein L28 (pseudogene) ML1674, len: 267 bp. Possible pseudogene similar to the M. tuberculosis 50S ribosomal proteins rpmB2|Rv2058 and rpmB1|Rv0105c (Best blastx scores: 125). P68998 Yes unknown PF00830 P68998 GO:0003735,GO:0006412,GO:0005840 AL450380.2 Mycobrowser_v4 CDS 2156725 2157666 . + 0 ML1780 ML1780 Conserved hypothetical protein (pseudogene) ML1780, len: 942 bp. Possible pseudogene of M. tuberculosis orthologue Rv2252 (930 bp) (Best blastx scores: 590). Yes lipid metabolism Rv2252 Rv2252 AL450380.2 Mycobrowser_v4 CDS 2021242 2021817 . + 0 ML1677 ML1677 POSSIBLE CONSERVED SECRETED PROTEIN ML1677, len: 191 aa. Possible conserved secreted protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2980 TR:P95115 (EMBL:Z83018) (181 aa), Fasta scores: E(): 0, 67.2% identity in 177 aa overlap. Contains a possible N-terminal signal sequence. Q9CBS1 No cell wall and cell processes Q9CBS1 Rv2980 Rv2980 AL450380.2 Mycobrowser_v4 CDS 2265611 2266563 . - 0 ML1887c echA4 Possible enoyl-CoA hydratase EchA4 (pseudogene) ML1887c, len: 953. Possible pseudogene of M. tuberculosis orthologue echA4|Rv0673 (939 bp) (Best blastx scores: 408). Yes lipid metabolism Rv0673 Rv0673 AL450380.2 Mycobrowser_v4 CDS 2362448 2363083 . + 0 ML1978 ML1978 Probable epoxide hydrolase (pseudogene) ML1978, len: 636 bp. Possible pseudogene similar to several M. tuberculosis probable epoxide hydrolases e.g. ephB|Rv1938, ephF|Rv0134, ephA|Rv3617, ephC|Rv1124 and ephE|Rv3670 (Best blastx scores: 132). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2157680 2158192 . - 0 ML1781c ML1781c conserved hypothetical protein ML1781c, len: 170. Conserved hypothetical protein. Similar to M. tuberculosis Rv2256c TR:O53530 (EMBL:AL021925) (177 aa), Fasta scores: E(): 0, 93.5% identity in 170 aa overlap, and to other hypothetical proteins e.g. TR:Q54209 (EMBL:L43074) unknown ORF downstream of Streptomyces glaucescens fabB (164 aa), Fasta scores: E(): 3.8e-27, 46.9% identity in 162 aa overlap. Q9CBN5 No conserved hypotheticals Q9CBN5 Rv2256c Rv2256c AL450380.2 Mycobrowser_v4 CDS 2073484 2073991 . + 0 ML1718 ML1718 Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase (pseudogene) ML1718, len: 508 bp. Possible pseudogene similar to M. tuberculosis panB|Rv2225 (846 bp) (Best blastx scores: 104), also similar to ML1635 a possible orthologue of M. tuberculosis panB. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2077989 2079654 . - 0 ML1722c ML1722c Conserved hypothetical protein (pseudogene) ML1722c, len: 1666 bp. Possible pseudogene of M. tuberculosis orthologue Rv3037c (1077 bp) (Best blastx scores: 298). Similarity to Rv3037 appears to have been intersected by the repeat element. Yes conserved hypotheticals Rv3037c Rv3037c AL450380.2 Mycobrowser_v4 CDS 2077206 2077904 . - 0 ML1721c ML1721c Probable conserved secreted protein TB22.2 homolog (pseudogene) ML1721c, len: 699 bp. Possible pseudogene of M. tuberculosis orthologue Rv3036c|TB22.2 (684 bp) (Best blastx scores: 382). Yes cell wall and cell processes Rv3036c Rv3036c AL450380.2 Mycobrowser_v4 CDS 2266578 2268074 . - 0 ML1888c fadE8 Probable acyl-CoA dehydrogenase FadE8 (pseudogene) ML1888c, len: 1497 bp. Possible pseudogene of M. tuberculosis orthologue fadE8|Rv0672 (1629 bp) (Best blastx scores: 347). Yes lipid metabolism Rv0672 Rv0672 AL450380.2 Mycobrowser_v4 CDS 2066115 2066957 . + 0 ML1713 ML1713 conserved hypothetical protein ML1713, len: 280 aa. Conserved hypothetical protein. Highly similar to several proteins of unknown function including: Mycobacterium tuberculosis Rv3030 TR:O53277 (EMBL:AL021287) (274 aa), Fasta scores: E(): 0, 78.2% identity in 280 aa overlap. Q7AQ25 No conserved hypotheticals PF08241 Q7AQ25 GO:0008168,GO:0008152 Rv3030 Rv3030 AL450380.2 Mycobrowser_v4 CDS 2356318 2356548 . - 0 ML1972c ML1972c hypothetical protein ML1972c, len: 76 aa. Hypothetical unknown protein. Q9CBH6 No unknown Q9CBH6 AL450380.2 Mycobrowser_v4 CDS 2091760 2093242 . - 0 ML1732c ML1732c Probable monooxygenase (pseudogene) ML1732c, len: 1483 bp. Possible pseudogene of M. tuberculosis orthologue Rv3049c (1575 bp) (Best blastx scores: 1312). Yes intermediary metabolism and respiration Rv3049c Rv3049c AL450380.2 Mycobrowser_v4 CDS 2076108 2077202 . + 0 ML1720 ML1720 conserved hypothetical protein ML1720, len: 364 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv3035 TR:O53282 (EMBL:AL021287) (360 aa), Fasta scores: E(): 0, 75.8% identity in 363 aa overlap. Q9CBR0 No conserved hypotheticals PF01011 Q9CBR0 Rv3035 Rv3035 AL450380.2 Mycobrowser_v4 CDS 2079782 2080765 . - 0 ML1723c ML1723c conserved hypothetical protein ML1723c, len: 327 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv3038c TR:O53285 (EMBL:AL021287) (327 aa), Fasta scores: E(): 0, 80.7% identity in 327 aa overlap. Q9CBQ9 No conserved hypotheticals PF08241 Q9CBQ9 GO:0008168,GO:0008152 Rv3038c Rv3038c AL450380.2 Mycobrowser_v4 CDS 2355416 2355555 . - 0 ML1971c ML1971c Possible transposase remnant (pseudogene) ML1971c, len: 140 bp. Possible transposase remnant, some similarity to Q9RBZ3 transposase from Pseudomonas syringae (1071 bp), (blastx scores: 51) and to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 41). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2093457 2094284 . - 0 ML1733c ML1733c Probable transcriptional regulatory protein tetR-family ML1733c, len: 275 aa. Probable transcriptional regulatory protein tetR-family. Similar to Mycobacterium tuberculosis Rv3050c TR:O53295 (EMBL:AL021287) (246 aa), Fasta scores: E(): 0, 86.6% identity in 238 aa overlap. Contains a putative helix-turn-helix motif situated between residues 79..100 (+3.98 SD). Contains a probable helix-turn-helix motif at aa 79-100 (Score 1407, SD +3.98) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Q9CBQ1 No regulatory proteins PF00440 Q9CBQ1 GO:0003700,GO:0006355 Rv3050c Rv3050c AL450380.2 Mycobrowser_v4 CDS 2106686 2108853 . - 0 ML1745c fadE22 Probable acyl-CoA dehydrogenase FadE22 (pseudogene) ML1745c, len: 2168 bp. Possible pseudogene of M. tuberculosis orthologue fadE22|Rv3061c (2166 bp) (Best blastx scores: 1078). Yes lipid metabolism Rv3061c Rv3061c AL450380.2 Mycobrowser_v4 CDS 2109182 2109549 . - 0 ML1746c ML1746c Probable short-chain dehydrogenase/reductase (pseudogene) ML1746c, len: 368 bp. Possible pseudogene similar to M. tuberculosis Rv1144 (753 bp) (Best blastx scores: 107). Also similar to ML0970 a possible pseudogene similar to M. tuberculosis Rv1144. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2110117 2111057 . + 0 ML1748 cstA Probable carbon starvation protein A homolog CstA (pseudogene) ML1748, len: 941 bp. Possible pseudogene of M. tuberculosis orthologue cstA|Rv3063 (2277 bp) (Best blastx scores: 200). Yes virulence, detoxification, adaptation Rv3063 Rv3063 AL450380.2 Mycobrowser_v4 CDS 2357584 2358387 . + 0 ML1973 ML1973 Possible beta-1,3-glucanase precursor (pseudogene) ML1973, len: 804 bp. Possible pseudogene similar to M. tuberculosis Rv0315 (885 bp) (Best blastx scores: 130). Also similar to ML2516c a possible pseudogene similar to M. tuberculosis Rv0315. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2096942 2097184 . - 0 ML1736c nrdH PROBABLE GLUTAREDOXIN ELECTRON TRANSPORT COMPONENT OF NRDEF (GLUTAREDOXIN-LIKE PROTEIN) NRDH ML1736c, len: 80 aa. Probable nrdH, glutaredoxin electron transport component of NrdE. Highly similar to many glutaredoxin-like proteins involved in electron transport for the ribonucleotide reductase system NrdEF, including: Escherichia coli SW:NRDH_ECOLI (Q47414) (81 aa), Fasta scores: E(): 1.1e-11, 44.0% identity in 75 aa overlap and Mycobacterium tuberculosis Rv3053c TR:P95106 (EMBL:Z83866) (79 aa), Fasta scores: E(): 7.7e-31, 91.1% identity in 79 aa overlap. Q9CBP8 No information pathways PF00462 Q9CBP8 GO:0009055,GO:0015035,GO:0045454 Rv3053c Rv3053c AL450380.2 Mycobrowser_v4 CDS 2096497 2096913 . - 0 ML1735c nrdI Probable NrdI-family protein ML1735c, len: 138 aa. Probable NrdI-family protein. Highly similar to many NrdI-family proteins, the function of which are unknown but thought to be involved with ribonucleoside reductase functioning, including: Escherichia coli SW:NRDI_ECOLI (Q47415) (136 aa), Fasta scores: E(): 2.7e-31, 59.3% identity in 135 aa overlap and Mycobacterium tuberculosis Rv3052c SW:NRDI_MYCTU (P95107) (150 aa), Fasta scores: E(): 0, 79.7% identity in 138 aa overlap. Q9CBP9 No information pathways PF07972 Q9CBP9 Rv3052c Rv3052c AL450380.2 Mycobrowser_v4 CDS 2133997 2134969 . - 0 ML1759c pgmA Probable phosphoglucomutase PgmA (pseudogene) ML1759c, len: 973 bp. Possible pseudogene of M. tuberculosis orthologue pgmA|Rv3068c (1644 bp) (Best blastx scores: 432). Yes intermediary metabolism and respiration Rv3068c Rv3068c AL450380.2 Mycobrowser_v4 CDS 2135609 2135852 . - 0 ML1760c ML1760c Possible integrase (fragment) (pseudogene) ML1760c, len: 244 bp. Possible pseudogene of M. tuberculosis orthologue Rv2309c (Best blastx scores: 88) Yes insertion seqs and phages Rv2309c Rv2309c AL450380.2 Mycobrowser_v4 CDS 2136886 2137949 . - 0 ML1762c ML1762c Probable conserved integral membrane alanine, valine and leucine rich protein (pseudogene) ML1762c, len: 1064 bp. Possible pseudogene similar to M. tuberculosis Rv2690c (1974 bp) (Best blastx scores: 105). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2139554 2139880 . + 0 ML1764 ML1764 putative potassium transport protein (pseudogene) ML1764, len: 327 bp. Possible pseudogene fragment, similar to part of several trkA (potassium transport) genes e.g. TRKA_METTH|O27333 (216 aa), Fasta scores: E(): 1.3, (33.8% identity in 71 aa overlap). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2140232 2140634 . - 0 ML1765c ML1765c Hypothetical protein (pseudogene) ML1765c, len: 403 bp. Possible pseudogene of M. tuberculosis orthologue Rv2313c (855 bp) (Best blastx scores: 125). Yes conserved hypotheticals Rv2313c Rv2313c AL450380.2 Mycobrowser_v4 CDS 2293655 2294083 . - 0 ML1909c ML1909c conserved hypothetical protein ML1909c, len: 142 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv0636 TR:P96927 (EMBL:Z92772) (142 aa), Fasta scores: E(): 0, 93.0% identity in 142 aa overlap. Also similar to ML2566 from M. leprae. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Q9CBJ7 No conserved hypotheticals, intermediary metabolism and respiration PF01575 Q9CBJ7 GO:0016491,GO:0008152 Rv0636 Rv0636 AL450380.2 Mycobrowser_v4 CDS 2161364 2161605 . + 0 ML1785 ML1785 Conserved hypothetical protein (pseudogene) ML1785, len: 242 bp. Possible pseudogene of M. tuberculosis orthologue Rv2260 (636 bp) (Best blastx scores: 156). Yes conserved hypotheticals Rv2260 Rv2260 AL450380.2 Mycobrowser_v4 CDS 2162536 2162837 . - 0 ML1786c ML1786c Conserved hypothetical protein (pseudogene) ML1786c, len: 302 bp. Possible pseudogene of M. tuberculosis orthologue Rv2261c (423 bp) (Best blastx scores: 202). Yes lipid metabolism Rv2261c Rv2261c AL450380.2 Mycobrowser_v4 CDS 2163102 2163387 . + 0 ML1787 cyp124 Probable cytochrome P-450 124 Cyp124 (pseudogene) ML1787, len: 286 bp. Possible pseudogene of M. tuberculosis orthologue Rv2266|cyp124 (1287 bp) (Best blastx scores: 246). Yes intermediary metabolism and respiration Rv2266 Rv2266 AL450380.2 Mycobrowser_v4 CDS 2164151 2164501 . + 0 ML1789 ML1789 Probable conserved transmembrane protein (pseudogene) ML1789, len: 351 bp. Possible pseudogene of M. tuberculosis orthologue Rv2272 (369 bp) (Best blastx scores: 221). Yes cell wall and cell processes Rv2272 Rv2272 AL450380.2 Mycobrowser_v4 CDS 2164522 2164820 . + 0 ML1790 ML1790 Probable conserved transmembrane protein (pseudogene) ML1790, len: 299 bp. Possible pseudogene of M. tuberculosis orthologue Rv2273 (330 bp) (Best blastx scores: 80). Yes cell wall and cell processes Rv2273 Rv2273 AL450380.2 Mycobrowser_v4 CDS 2166754 2168343 . + 0 ML1792 yjcE Probable conserved integral membrane transport protein YjcE (pseudogene) ML1792, len: 1590 bp. Possible pseudogene of M. tuberculosis orthologue yjcE|Rv2287 (1629 bp) (Best blastx scores: 885). Yes cell wall and cell processes Rv2287 Rv2287 AL450380.2 Mycobrowser_v4 CDS 2176417 2176785 . - 0 ML1797c lipL Probable esterase LipL (pseudogene) ML1797c, len: 369 bp. Possible pseudogene similar to M. tuberculosis orthologue lipL|Rv1497 (1290 bp) (Best blastx scores: 94). Yes intermediary metabolism and respiration Rv1497 Rv1497 AL450380.2 Mycobrowser_v4 CDS 2182292 2182977 . + 0 ML1801 ML1801 Conserved membrane protein (pseudogene) ML1801, len: 686 bp. Possible pseudogene of M. tuberculosis orthologue Rv1491c (759 bp) (Best blastx scores: 268). Yes cell wall and cell processes Rv1491c Rv1491c AL450380.2 Mycobrowser_v4 CDS 2211568 2211769 . - 0 ML1826c cobU Probable bifunctional cobalamin biosynthesis protein CobU: cobinamide kinase + cobinamide phosphate guanyltransferase (pseudogene) ML1826c, len: 202 bp. Possible pseudogene of M. tuberculosis orthologue cobU|Rv0254c (525 bp0 (Best blastx scores: 185). Yes intermediary metabolism and respiration Rv0254c Rv0254c AL450380.2 Mycobrowser_v4 CDS 2175309 2175722 . + 0 ML1796 ML1796 hypothetical protein ML1796, len: 137 aa. Hypothetical unknown protein, previously sequenced as Y15K_MYCLE|P13733 (137 aa), Fasta scores: E(): 0, 100.0% identity in 137 aa overlap. P13733 No unknown P13733 AL450380.2 Mycobrowser_v4 CDS 2210336 2210475 . - 0 ML1825c ML1825c Possible transposase remnant (pseudogene) ML1825c, len: 140 bp. Possible transposase remnant, some similarity to Q9RBZ3 transposase from Pseudomonas syringae (1071 bp), (blastx scores: 51) and to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 45). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2214304 2214507 . + 0 ML1828A ML1828A Conserved hypothetical protein (pseudogene) ML1828A, len: 204 bp. Possible pseudogene of M. tuberculosis orthologue Rv0257 (375 bp) (Best blastx scores: 186). Yes conserved hypotheticals Rv0257 Rv0257 AL450380.2 Mycobrowser_v4 CDS 2433663 2434137 . + 0 ML2043 ahpD Alkyl hydroperoxide reductase AhpD (pseudogene) ML2043, len: 475 bp. Possible pseudogene of M. tuberculosis orthologue ahpD|Rv2429 (534 bp) (Best blastx scores: 150). Yes virulence, detoxification, adaptation Rv2429 Rv2429 AL450380.2 Mycobrowser_v4 CDS 2184363 2184794 . - 0 ML1803c ML1803c CONSERVED MEMBRANE PROTEIN ML1803c, len: 143 aa. Conserved membrane protein. Similar to M. tuberculosis Rv1487 TR:P71767 (EMBL:Z79701) (144 aa), Fasta scores: E(): 0, 74.8% identity in 143 aa overlap, and to many others e.g. Streptomyces coelicolor putative integral membrane protein SCI5.05C TR:Q9X9Z5 (EMBL:AL079332) (143 aa), Fasta scores: E(): 1.3e-12, 42.3% identity in 137 aa overlap. Q9CBM4 No cell wall and cell processes PF01957 Q9CBM4 Rv1487 Rv1487 AL450380.2 Mycobrowser_v4 CDS 2198693 2198854 . - 0 ML1815A ML1815A Possible transcriptional regulatory protein ML1815A, len: 162 bp. Possible pseudogene similar to M. tuberculosis Rv1473A (192 bp) (Best blastx score: 99). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2203046 2204013 . + 0 ML1820 ML1820 Possible adenylate cyclase (pseudogene) ML1820, len: 968 bp. Possible pseudogene similar to the M. tuberculosis adenylate cyclases e.g. Rv1318c, Rv1319c and Rv1320c (Best blastx scores: 265). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2204133 2204295 . + 0 ML1820A ML1820A Probable transposase (pseudogene) ML1820A, len: 163 bp. Possible pseudogene similar to several M. tuberculosis transposases associated with IS6110 (Best blastx scores: 75) and identical to ML1291c, ML1242A, ML0599A, ML0568B from M. leprae. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2205588 2206235 . + 0 ML1822 ML1822 Probable cutinase (pseudogene) ML1822, len: 648 bp. Possible pseudogene similar to the M. tuberculosis cutinases e.g. cut2|Rv2301, cut4|Rv3452 and cut3|Rv3451 (Best blastx scores: 415). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2507533 2507827 . - 0 ML2108c ML2108c Conserved hypothetical protein (pseudogene) ML2108c, len: 295 bp. Possible pseudogene of M. tuberculosis orthologue Rv0918 (477 bp) (Best blastx scores: 147). Yes conserved hypotheticals Rv0918 Rv0918 AL450380.2 Mycobrowser_v4 CDS 2189526 2190488 . - 0 ML1809c ML1809c conserved hypothetical protein ML1809c, len: 320 aa. Conserved hypothetical protein. Similar to M. tuberculosis Rv1480 SW:YE80_MYCTU (P71761) (317 aa), Fasta scores: E(): 0, 87.5% identity in 311 aa overlap. Contains Pfam match to entry PF01882 DUF58, Protein of unknown function. Q9CBL8 No conserved hypotheticals PF01882 Q9CBL8 Rv1480 Rv1480 AL450380.2 Mycobrowser_v4 CDS 2194284 2194856 . - 0 ML1813c ML1813c POSSIBLE MEMBRANE PROTEIN ML1813c, len: 190 aa. Possible membrane protein. Similar to M. tuberculosis hypothetical protein Rv1476 TR:O53167 (EMBL:AL021184) (186 aa), Fasta scores: E(): 0, 78.7% identity in 178 aa overlap. Q9CBL4 No cell wall and cell processes Q9CBL4 Rv1476 Rv1476 AL450380.2 Mycobrowser_v4 CDS 2279883 2280351 . + 0 ML1894 ML1894 Possible transcriptional regulatory protein (pseudogene) ML1894, len: 469 bp. Possible pseudogene of M. tuberculosis orthologue Rv0653c (696 bp) (Best blastx scores: 142). Yes regulatory proteins Rv0653c Rv0653c AL450380.2 Mycobrowser_v4 CDS 2208988 2210131 . - 0 ML1824c ML1824c Putative group II intron maturase-related protein (pseudogene) ML1824c, len: 1144 bp. Possible pseudogene, similar to several maturases e.g. Q9MD87|AF218567 putative maturase from Cryphonectria parasitica (Cheshnut blight fungus) (2334 bp), (blastx scores: 143); and Rv0071|O53616 Putative maturase from M. tuberculosis (705 bp), (blastx scores: 153). Belongs to the LEPREP family of dispersed repeats (see citation below) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2222460 2223127 . + 0 ML1834 ML1834 Conserved hypothetical protein (pseudogene) ML1834, len: 668 bp. Possible pseudogene of M. tuberculosis orthologue Rv0731c (957 bp) (Best blastx scores: 125). Yes lipid metabolism Rv0731c Rv0731c AL450380.2 Mycobrowser_v4 CDS 2224000 2225000 . - 0 ML1836c xylB Possible d-xylulose kinase XylB (pseudogene) ML1836c, len: 1001 bp. Possible pseudogene of M. tuberculosis orthologue xylB|Rv0729 (1347 bp) (Best blastx scores: 417). Yes intermediary metabolism and respiration Rv0729 Rv0729 AL450380.2 Mycobrowser_v4 CDS 2225035 2226016 . + 0 ML1837 serA2 Possible D-3-phosphoglycerate dehydrogenase SerA2 (pseudogene) ML1837, len: 982 bp. Possible pseudogene of M. tuberculosis orthologue Rv0728c|serA2 (981 bp) (Best blastx scores: 581). Yes intermediary metabolism and respiration Rv0728c Rv0728c AL450380.2 Mycobrowser_v4 CDS 2226096 2226453 . + 0 ML1838 fucA Possible L-fuculose phosphate aldolase FucA (pseudogene) ML1838, len: 358 bp. Possible pseudogene of M. tuberculosis orthologue fucA|0727c (657 bp) (Best blastx scores: 229). Yes intermediary metabolism and respiration Rv0727c Rv0727c AL450380.2 Mycobrowser_v4 CDS 2223223 2223906 . - 0 ML1835c ML1835c conserved hypothetical protein ML1835c, len: 227 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv0730 TR:O53794 (EMBL:AL021958) (242 aa), Fasta scores: E(): 0, 83.5% identity in 218 aa overlap. Q7AQ21 No conserved hypotheticals, intermediary metabolism and respiration Q7AQ21 Rv0730 Rv0730 AL450380.2 Mycobrowser_v4 CDS 2228987 2229427 . - 0 ML1840c rplO PROBABLE 50S RIBOSOMAL PROTEIN L15 RPLO ML1840c, len: 146 aa. Probable rplO, 50S ribosomal protein L15. Similar to M. tuberculosis 50S ribosomal protein L15 Rv0723 SW:RL15_MYCTU (P95071) (146 aa), Fasta scores: E(): 0, 81.5% identity in 146 aa overlap. Contains Pfam match to entry PF00256 L15, Ribosomal protein L15. Contains Pfam match to entry PF01305 Ribosomal_L15, Ribosomal protein L15 amino terminal region. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00475 Ribosomal protein L15 signature. O33002 No information pathways PF00256,PF01305 O33002 GO:0019843,GO:0003735,GO:0006412,GO:0015934 Rv0723 Rv0723 AL450380.2 Mycobrowser_v4 CDS 2229428 2229643 . - 0 ML1841c rpmD PROBABLE 50S RIBOSOMAL PROTEIN L30 RPMD ML1841c, len: 71 aa. Probable rpmD, 50S ribosomal protein L30. Similar to M. tuberculosis 50S ribosomal protein L30 Rv0722 SW:RL30_MYCTU (Z84395) (65 aa), Fasta scores: E(): 1.1e-21, 89.2% identity in 65 aa overlap. Contains Pfam match to entry PF00327 Ribosomal_L30, Ribosomal protein L30p/L7e. O33001 No information pathways PF00327 O33001 GO:0003735,GO:0006412,GO:0015934 Rv0722 Rv0722 AL450380.2 Mycobrowser_v4 CDS 2245516 2246911 . - 0 ML1866c ML1866c Probable dehydrogenase (pseudogene) ML1866c, len: 1396 bp. Possible pseudogene of M. tuberculosis orthologue Rv0697 (1440 bp) (Best blastx scores: 550). Yes intermediary metabolism and respiration Rv0697 Rv0697 AL450380.2 Mycobrowser_v4 CDS 2246918 2248130 . - 0 ML1867c ML1867c Probable membrane sugar transferase (pseudogene) ML1867c, len: 1213 bp. Possible pseudogene of M. tuberculosis orthologue Rv0696 (1413 bp) (Best blastx scores: 202). Yes intermediary metabolism and respiration Rv0696 Rv0696 AL450380.2 Mycobrowser_v4 CDS 2301842 2302633 . - 0 ML1918c ML1918c PROBABLE CONSERVED MEMBRANE PROTEIN ML1918c, len: 263 aa. Probable conserved membrane protein. Similar to M. tuberculosis membrane protein Rv3587c TR:O53572 (EMBL:AL022075) (264 aa), Fasta scores: E(): 0, 77.5% identity in 267 aa overlap. Contains probable transmembrane domain. Q9CBJ2 No cell wall and cell processes Q9CBJ2 Rv3587c Rv3587c AL450380.2 Mycobrowser_v4 CDS 2242246 2242938 . - 0 ML1862c rplD PROBABLE 50S RIBOSOMAL PROTEIN L4 RPLD ML1862c, len: 230 aa. Probable rplD, 50S ribosomal protein L4. Similar to M. tuberculosis 50S ribosomal protein L4 Rv0702 SW:RL4_MYCTU (P95050) (223 aa), Fasta scores: E(): 0, 86.7% identity in 218 aa overlap. Contains Pfam match to entry PF00573 Ribosomal_L4, Ribosomal protein L4/L1 family. O32982 No information pathways PF00573 O32982 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0702 Rv0702 AL450380.2 Mycobrowser_v4 CDS 2243607 2243912 . - 0 ML1864c rpsJ 30S RIBOSOMAL PROTEIN S10 RPSJ (TRANSCRIPTION ANTITERMINATION FACTOR NUSE) ML1864c, len: 101 aa. Probable rpsJ, 30S ribosomal protein S10. Similar to M. tuberculosis 30S ribosomal protein S10 Rv0700 SW:RS10_MYCTU (P95048) (101 aa), Fasta scores: E(): 0, 97.0% identity in 101 aa overlap. Contains Pfam match to entry PF00338 Ribosomal_S10, Ribosomal protein S10p/S20e. Contains PS00361 Ribosomal protein S10 signature. P30765 No information pathways PF00338 P30765 GO:0003735,GO:0000049,GO:0006412,GO:0015935 Rv0700 Rv0700 AL450380.2 Mycobrowser_v4 CDS 2988601 2988978 . - 0 ML2508c ML2508c Possible conserved exported protein (pseudogene) ML2508c, len: 378 bp. Possible pseudogene of M. tuberculosis orthologue Rv0320 (663 bp) (Best blastx scores: 205). Yes cell wall and cell processes Rv0320 Rv0320 AL450380.2 Mycobrowser_v4 CDS 2280442 2280834 . - 0 ML1895c rplL PROBABLE 50S RIBOSOMAL PROTEIN L7/L12 RPLL (SA1) ML1895c, len: 130 aa. Probable rplL, 50S ribosomal protein L7/L12. Similar to M. tuberculosis 50S ribosomal protein L7/L12 rplL Rv0652 SW:RL7_MYCTU (P37381) (130 aa), Fasta scores: E(): 0, 88.5% identity in 130 aa overlap. Contains Pfam match to entry PF00542 Ribosomal_L12, Ribosomal protein L7/L12 C-terminal domain. P30763 No information pathways PF00542 P30763 GO:0003735,GO:0006412,GO:0005840 Rv0652 Rv0652 AL450380.2 Mycobrowser_v4 CDS 2269277 2273227 . - 0 ML1890c rpoC DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). ML1890c, len: 1316 aa. Probable rpoC, DNA-directed RNA polymerase, beta' chain (EC 2.7.7.6). Similar to M. tuberculosis DNA-directed RNA polymerase beta chain Rv0668 SW:RPOC_MYCTU (P47769) (1316 aa), Fasta scores: E(): 0, 95.6% identity in 1316 aa overlap, and to many others e.g. Escherichia coli SW:RPOC_ECOLI (P00577) (1407 aa), Fasta scores: E(): 0, 42.5% identity in 1461 aa overlap. Contains Pfam match to entry PF00623 RNA_pol_A, RNA polymerase alpha subunit. Contains Pfam match to entry PF01854 RNA_pol_A2, RNA polymerase A/beta'/A subunit. P30761 No information pathways PF00623,PF04983,PF04997,PF04998,PF05000 P30761 GO:0003899,GO:0006351,GO:0003677 2.7.7.6 Rv0668 Rv0668 AL450380.2 Mycobrowser_v4 CDS 2290316 2291023 . - 0 ML1904c rplA PROBABLE 50S RIBOSOMAL PROTEIN L1 RPLA ML1904c, len: 235 aa. Probable rplA, 50S ribosomal protein L1. Similar to M. tuberculosis 50S ribosomal protein L1 Rv0641 SW:RL1_MYCTU (P96932) (235 aa), Fasta scores: E(): 0, 93.6% identity in 235 aa overlap. Contains Pfam match to entry PF00687 Ribosomal_L1, L1P family of ribosomal proteins. Q9CBK2 No information pathways PF00687 Q9CBK2 GO:0015934,GO:0019843,GO:0006417,GO:0003735,GO:0000049,GO:0006412,GO:0006396 Rv0641 Rv0641 AL450380.2 Mycobrowser_v4 CDS 2313726 2314558 . + 0 ML1931 xthA Probable exodeoxyribonuclease III protein XthA (pseudogene) ML1931, len: 833 bp. Possible pseudogene of M. tuberculosis orthologue xthA|Rv0427c (876 bp) (Best blastx scores: 398). Yes information pathways Rv0427c Rv0427c AL450380.2 Mycobrowser_v4 CDS 2315486 2319485 . + 0 ML1933 ctpH Possible metal cation-transporting P-type ATPase CtpH (pseudogene) ML1933, len: 4000 bp. Possible pseudogene of M. tuberculosis orthologue ctpH|Rv0425c (4620 bp) (Best blastx scores: 523). Yes cell wall and cell processes Rv0425c Rv0425c AL450380.2 Mycobrowser_v4 CDS 2319579 2319818 . + 0 ML1934 ML1934 Hypothetical protein (pseudogene) ML1934, len: 240 bp. Possible pseudogene of M. tuberculosis orthologue Rv0424c (276 bp) (Best blastx scores: 230). Yes conserved hypotheticals Rv0424c Rv0424c AL450380.2 Mycobrowser_v4 CDS 2320083 2321097 . - 0 ML1935c ML1935c PPE-family protein (pseudogene) ML1935c, len: 1015 bp. Possible pseudogene similar to several M. tuberculosis PPE-family proteins e.g. PPE61|Rv3532, PPE51|Rv3136 and PPE26|Rv1789 (Best blastx scores: 197). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2304314 2305084 . - 0 ML1921c ML1921c POSSIBLE HYDROLASE ML1921c, len: 256 aa. Possible hydrolase. Similar to several e.g. M. tuberculosis Rv3591c TR:O06157 (EMBL:Z95555) Possible hydrolase (257 aa), Fasta scores: E(): 0, 79.0% identity in 248 aa overlap. And similar to ML2269 from M. leprae. Q9CBI9 No intermediary metabolism and respiration PF00561 Q9CBI9 Rv3591c Rv3591c AL450380.2 Mycobrowser_v4 CDS 2353705 2353803 . - 0 ML1969c ML1969c Possible transposase remnant (pseudogene) ML1969c, len: 99 bp. Possible transposase remnant, similar to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 93); and to Q9R9U9|AJ245436 transposase tnpa1 from Pseudomonas putida (1065 bp), (blastx scores: 89). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2295163 2295378 . - 0 ML1911A ML1911A conserved hypothetical protein ML1911A, len: 71 aa. Conserved hypothetical protein. Orthologous to M. tuberculosis Rv0634A but may be pseudogene as Rv0634A is predicted to be 13 aa longer. Also similar to M. tuberculosis Rv1560, sp|Q10771|YF60_MYCTU HYPOTHETICAL 8.2 KDA PROTEIN Rv1560 (72 aa) E(): 0.0025; 47.500% identity in 40 aa overlap Q7AQ19 No conserved hypotheticals Q7AQ19 Rv0634A Rv0634A AL450380.2 Mycobrowser_v4 CDS 2294596 2294763 . - 0 ML1911c rpmG2 PROBABLE 50S RIBOSOMAL PROTEIN L33 RPMG2 ML1911c, len: 55 aa. Probable rpmG2, 50S ribosomal protein L33 type 2. Similar to M. tuberculosis 50S ribosomal protein L33 type 2 SW:R332_MYCTU (P96925) (55 aa), Fasta scores: E(): 5.5e-24, 92.7% identity in 55 aa overlap. Contains PS00582 Ribosomal protein L33 signature. Q9CBJ5 No information pathways PF00471 Q9CBJ5 GO:0003735,GO:0006412,GO:0005840 Rv0634B Rv0634B AL450380.2 Mycobrowser_v4 CDS 2335197 2335915 . - 0 ML1948c ML1948c probable transmembrane protein (pseudogene) ML1948c, len: 719 bp. Possible pseudogene similar to M. tuberculosis Rv3645 (Best blastx scores: 178) also similar to the M. tuberculosis Rv1318, Rv1319 and Rv1320. Also similar to ML0201c a possible orthologue of M. tuberculosis Rv3645. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2377172 2377414 . - 0 ML1990c ML1990c Possible membrane protein ML1990c, len: 80 aa. Possible membrane protein. Contains possible membrane spanning hydrophobic domains. Q9CBG6 No cell wall and cell processes Q9CBG6 AL450380.2 Mycobrowser_v4 CDS 2323420 2324559 . + 0 ML1937 ML1937 probable integral membrane protein ML1937, len: 379 aa. Probable integral membrane protein. Similar to M. tuberculosis hypothetical protein Rv1111c TR:O86351 (EMBL:AL021897) (327 aa), Fasta scores: E(): 5.6e-31, 45.7% identity in 374 aa overlap. The N-terminus contains possible membrane spanning hydrophobic domains. Note start changed since original submission. Q9CBI0 No cell wall and cell processes, conserved hypotheticals Q9CBI0 Rv1111c Rv1111c AL450380.2 Mycobrowser_v4 CDS 2390671 2390925 . - 0 ML1999c ML1999c Putative carboxyvinyl-carboxyphosphonate phosphorylmutase (pseudogene) ML1999c, len: 255 bp. Possible pseudogene similar to part of many carboxyvinyl-carboxyphosphonate phosphorylmutase genes e.g. CPPM_AERPE from Aeropyrum pernix (Blastx scores: 131). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2352625 2352852 . - 0 ML1967c ML1967c PPE family protein (pseudogene) ML1967c, len: 228 bp. Possible pseudogene similar to several M. tuberculosis PPE family proteins e.g. PPE16|Rv1135c, PPE41|Rv2430c, PPE22|Rv1705c, PPE24|Rv1753c etc (Best blastx scores: 108). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2353321 2353506 . - 0 ML1968c ML1968c PE family protein (pseudogene) ML1968c, len: 186 bp. Possible pseudogene similar to several M. tuberculosis PPE family proteins e.g. PE25|Rv2431c, PE13|Rv1195 and PE8|Rv1040c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2344177 2344689 . - 0 ML1956c rplQ PROBABLE 50S RIBOSOMAL PROTEIN L17 RPLQ ML1956c, len: 170 aa. Probable rplQ, 50S ribosomal protein L17. Similar to M. tuberculosis 50S ribosomal protein L17 rplQ Rv3456c SW:RL17_MYCTU (O06323) (180 aa), Fasta scores: E(): 0, 81.9% identity in 171 aa overlap. Contains Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17. Q9X797 No information pathways PF01196 Q9X797 GO:0003735,GO:0006412,GO:0005840 Rv3456c Rv3456c AL450380.2 Mycobrowser_v4 CDS 2410551 2410704 . - 0 ML2018c ML2018c Conserved hypothetical protein (pseudogene) ML2018c, len: 154 bp. Possible pseudogene of M. tuberculosis orthologue Rv1898 (309 bp) (Best blastx scores: 80). Yes conserved hypotheticals Rv1898 Rv1898 AL450380.2 Mycobrowser_v4 CDS 2367425 2367892 . + 0 ML1983 ML1983 conserved hypothetical protein ML1983, len: 468 aa. Conserved hypothetical protein. Similar to M. tuberculosis gene Rv1919c TR:O53961 (EMBL:AL022020) (154 aa), Fasta scores: E(): 0, 72.8% identity in 151 aa overlap. Q9CBH1 No conserved hypotheticals PF10604 Q9CBH1 Rv1919c Rv1919c AL450380.2 Mycobrowser_v4 CDS 2376742 2377092 . - 0 ML1989c ML1989c hypothetical protein ML1989c, len: 116 aa. Hypothetical unknown protein. Q9CBG7 No unknown Q9CBG7 AL450380.2 Mycobrowser_v4 CDS 2366604 2366912 . + 0 ML1982 ML1982 Possible membrane protein ML1982, len: 102 aa. Possible membrane protein. Some similarity to transport proteins e.g. ATOE_ECOLI|P76460 Escherichia coli short-chain fatty acids transporter (440 aa), Fasta scores: E(): 0.064, (32.7% identity in 55 aa overlap). Contains a hydrophobic membrane spanning region. Q9CBH2 No cell wall and cell processes PF02667 Q9CBH2 GO:0015912,GO:0015635,GO:0016020 AL450380.2 Mycobrowser_v4 CDS 2395793 2396193 . - 0 ML2003c ML2003c Probable oxidoreductase dehydrogenase (pseudogene) ML2003c, len: 401 bp. Possible pseudogene similar to M. tuberculosis Rv3829c (1611 bp) (Best blastx scores: 121). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2396415 2396672 . + 0 ML2004 ML2004 Possible hydrolase (pseudogene) ML2004, len: 258 bp. Possible pseudogene similar to several M. tuberculosis putative hydrolases e.g. Rv2715 (Best blastx scores: 114). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2396769 2397465 . + 0 ML2005 ML2005 Conserved hypothetical protein (pseudogene) ML2005, len: 697 bp. Possible pseudogene similar to M. tuberculosis Rv0021c (969 bp) (Best blastx scores: 197). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2398936 2399334 . + 0 ML2006 ML2006 Conserved hypothetical protein (pseudogene) ML2006, len: 399 bp. Possible pseudogene similar to M. tuberculosis Rv3368c (435 bp) (Best blastx scores: 130). Also similar to ML0418 a possible orthologue of M. tuberculosis Rv3368c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2400382 2400839 . + 0 ML2008 furA Ferric uptake regulatory protein FurA (pseudogene) ML2008, len: 458 bp. Possible pseudogene of M. tuberculosis orthologue furA|Rv1909c (453 bp) (Best blastx scores: 118). Yes regulatory proteins Rv1909c Rv1909c AL450380.2 Mycobrowser_v4 CDS 2400874 2402892 . + 0 ML2009 katG Catalase-peroxidase-peroxynitritase T KatG (pseudogene) ML2009, len: 2019 bp. Possible pseudogene of M. tuberculosis orthologue katG|Rv1908c (2223 bp) (Best blastx scores: 391). Yes virulence, detoxification, adaptation Rv1908c Rv1908c AL450380.2 Mycobrowser_v4 CDS 2406049 2407287 . + 0 ML2014 nanT Probable sialic-acid transport integral membrane protein NanT (pseudogene) ML2014, len: 1239 bp. Possible pseudogene of M. tuberculosis orthologue nanT|Rv1902c (1269 bp) (Best blastx scores: 578). Yes cell wall and cell processes Rv1902c Rv1902c AL450380.2 Mycobrowser_v4 CDS 2427964 2428263 . - 0 ML2037c glnA3 Probable glutamine synthase GlnA3 (pseudogene) ML2037c, len: 300 bp. Possible pseudogene of M. tuberculosis orthologue glnA3|Rv1878 (1353 bp) (Best blastx scores: 129). Yes intermediary metabolism and respiration Rv1878 Rv1878 AL450380.2 Mycobrowser_v4 CDS 2408635 2409822 . + 0 ML2016 lipJ Probable lignin peroxidase LipJ (pseudogene) ML2016, len: 1188 bp. Possible pseudogene of M. tuberculosis orthologue lipJ|Rv1900c (1389 bp) (Best blastx scores: 394). Yes intermediary metabolism and respiration Rv1900c Rv1900c AL450380.2 Mycobrowser_v4 CDS 2410032 2410502 . + 0 ML2017 lppD Possible lipoprotein LppD (pseudogene) ML2017, len: 471 bp. Possible pseudogene of M. tuberculosis orthologue lppD|Rv1899c (1032 bp) (Best blastx scores: 230). Yes cell wall and cell processes Rv1899c Rv1899c AL450380.2 Mycobrowser_v4 CDS 2421158 2421613 . + 0 ML2031 ML2031 conserved hypothetical protein ML2031, len: 151 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein TR:O07748 (EMBL:Z97193) fasta scores: E(): 0, 76.2% in 151 aa, and to Streptomyces actuosus NSH-OrfB TR:P72384 (EMBL:U75434) fasta scores: E(): 2.5e-08, 34.4% in 125 aa. Q9CBF7 No conserved hypotheticals PF03364 Q9CBF7 Rv1883c Rv1883c AL450380.2 Mycobrowser_v4 CDS 2434255 2435512 . + 0 ML2044 ML2044 Possible glycosyl hydrolase (pseudogene) ML2044, len: 1041 bp. Possible pseudogene similar to several glycosyl hydrolases e.g. Q8G5U5 possible cyclomaltodextrinase or neopullalanase from Bifidobacterium longum (best blastx score: 497). Q9CBF4 Yes unknown Q9CBF4 AL450380.2 Mycobrowser_v4 CDS 2437213 2437530 . + 0 ML2047 ML2047 Conserved hypothetical protein (pseudogene) ML2047, len: 318 bp. Possible pseudogene similar to M. tuberculosis Rv1991c (345 bp) (Best blastx scores: 129). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2438461 2439063 . + 0 ML2049 ML2049 Conserved hypothetical protein (pseudogene) ML2049, len: 603 bp. Possible pseudogene of M. tuberculosis orthologue Rv1870c (636 bp) (Best blastx scores: 365). Yes conserved hypotheticals Rv1870c Rv1870c AL450380.2 Mycobrowser_v4 CDS 2440116 2440451 . + 0 ML2051 ML2051 Conserved hypothetical protein (pseudogene) ML2051, len: 336 bp. Possible pseudogene of M. tuberculosis orthologue Rv1864c (756 bp) (Best blastx scores: 204). Yes conserved hypotheticals Rv1864c Rv1864c AL450380.2 Mycobrowser_v4 CDS 2440427 2441095 . + 0 ML2052 ML2052 Probable conserved integral membrane protein (pseudogene) ML2052, len: 669 bp. Possible pseudogene of M. tuberculosis orthologue Rv1863c (771 bp) (Best blastx scores: 190). Yes cell wall and cell processes Rv1863c Rv1863c AL450380.2 Mycobrowser_v4 CDS 2444731 2445523 . - 0 ML2057c modB Probable molybdenum-transport integral membrane protein ABC transporter ModB (pseudogene) ML2057c, len: 793 bp. Possible pseudogene of M. tuberculosis orthologue modB|Rv1858 (795 bp) (Best blastx scores: 427). Yes cell wall and cell processes Rv1858 Rv1858 AL450380.2 Mycobrowser_v4 CDS 3015191 3016108 . - 0 ML2533c PPE PPE-family protein (pseudogene) ML2533c, len: 918 bp. Possible pseudogene of M. tuberculosis orthologue PPE4|Rv0286 (1542 bp) (Best blastx scores: 361). Yes PE/PPE Rv0286 Rv0286 AL450380.2 Mycobrowser_v4 CDS 2445553 2446325 . - 0 ML2058c modA Probable molybdate-binding lipoprotein ModA (pseudogene) ML2058c, len: 773 bp. Possible pseudogene of M. tuberculosis orthologue modA|Rv1857 (786 bp) (Best blastx scores: 260). Yes cell wall and cell processes Rv1857 Rv1857 AL450380.2 Mycobrowser_v4 CDS 2447305 2448252 . + 0 ML2060 ML2060 Possible oxidoreductase (pseudogene) ML2060, len: 948 bp. Possible pseudogene of M. tuberculosis orthologue Rv1855c (924 bp) (Best blastx scores: 359). Yes intermediary metabolism and respiration Rv1855c Rv1855c AL450380.2 Mycobrowser_v4 CDS 2450045 2450276 . - 0 ML2062c ML2062c Conserved hypothetical protein (pseudogene) ML2062c, len: 232 bp. Possible pseudogene of M. tuberculosis orthologue Rv1847 (423 bp) (Best blastx scores: 84). Yes conserved hypotheticals Rv1847 Rv1847 AL450380.2 Mycobrowser_v4 CDS 2455398 2456700 . + 0 ML2067 ML2067 Conserved hypothetical membrane protein (pseudogene) ML2067, len: 1303 bp. Possible pseudogene of M. tuberculosis orthologue Rv1842c (Best blastx scores: 692). Yes cell wall and cell processes Rv1842c Rv1842c AL450380.2 Mycobrowser_v4 CDS 2437812 2438069 . + 0 ML2048 ML2048 conserved hypothetical protein ML2048, len: 85 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1871 TR:P95144 (EMBL:AL204060) fasta scores: E(): 4.7e-16, 62.0% in 79 aa, and to Streptomyces coelicolor hypothetical protein TR:CAB88434 (EMBL:AL353815) fasta scores: E(): 0.0092, 39.3% in 61 aa; truncated at C-terminus; may represent a pseudogene. Q7AQ01 No conserved hypotheticals Q7AQ01 Rv1871c Rv1871c AL450380.2 Mycobrowser_v4 CDS 2456700 2457647 . + 0 ML2068 ML2068 Conserved hypothetical membrane protein (pseudogene) ML2068, len: 948 bp. Possible pseudogene of M. tuberculosis orthologue Rv1841c (1038 bp (Best blastx scores: 512). Yes cell wall and cell processes Rv1841c Rv1841c AL450380.2 Mycobrowser_v4 CDS 2462551 2463353 . + 0 ML2071 ML2071 Possible haloalkane dehalogenase (pseudogene) ML2071, len: 803 bp. Possible pseudogene of M. tuberculosis orthologue Rv1833c (861 bp) (Best blastx scores: 229). Yes intermediary metabolism and respiration Rv1833c Rv1833c AL450380.2 Mycobrowser_v4 CDS 2578305 2578742 . - 0 ML2169c ML2169c Probable fatty-acid-CoA synthetase (pseudogene) ML2169c, len: 438 bp. Possible pseudogene similar to M. tuberculosis orthologue fadD3|Rv3561 (1524 bp) (Best blastx scores: 124). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2470758 2471082 . - 0 ML2079c ML2079c Conserved hypothetical membrane protein (pseudogene) ML2079c, len: 325 bp. Possible pseudogene of M. tuberculosis orthologue Rv1824 (366 bp) (Best blastx scores: 359). Yes cell wall and cell processes Rv1824 Rv1824 AL450380.2 Mycobrowser_v4 CDS 2460324 2462525 . + 0 ML2070 ML2070 conserved hypothetical protein ML2070, len: 733 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 69.7 kda protein Rv1836c SW:YI36_MYCTU (Q50597) fasta scores: E(): 0, 66.0% in 714 aa. Q9CBE8 No conserved hypotheticals Q9CBE8 Rv1836c Rv1836c AL450380.2 Mycobrowser_v4 CDS 2619146 2619334 . + 0 ML2204 ML2204 conserved hypothetical protein ML2204, len: 62 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 6.9 kda protein Rv0810c TR:O53824 (EMBL:AL022004) fasta scores: E(): 9.9e-17, 77.8% identity in 63 aa, and to Streptomyces coelicolor hypothetical 9.3 kda protein SCD25.24C TR:Q9RKJ8 (EMBL:AL118514) fasta scores: E(): 1.3e-06, 46.8% identity in 62 aa. Q9CBC3 No conserved hypotheticals Q9CBC3 Rv0810c Rv0810c AL450380.2 Mycobrowser_v4 CDS 2466452 2467147 . - 0 ML2073c ML2073c conserved hypothetical protein ML2073c, len: 231 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 24.0 kda protein Rv1830 SW:YI30_MYCTU (Q50603) fasta scores: E(): 0, 90.0% in 231 aa, and to Streptomyces coelicolor hypothetical 19.1 kda protein TR:CAB88877 (EMBL:AL353861) fasta scores: E(): 3.7e-30, 64.8% in 145 aa. Q7APZ6 No conserved hypotheticals Q7APZ6 GO:0006355,GO:0003700,GO:0000166 Rv1830 Rv1830 AL450380.2 Mycobrowser_v4 CDS 2467380 2467874 . - 0 ML2074c ML2074c conserved hypothetical protein ML2074c, len: 164 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 18.1 kda protein Rv1829 SW:YI29_MYCTU (Q50604) fasta scores: E(): 0, 95.1% in 164 aa, and to Streptomyces coelicolor conserved hypothetical protein TR:CAB88878 (EMBL:AL353861) fasta scores: E(): 0, 60.9% in 161 aa. Q7APZ5 No conserved hypotheticals PF02577 Q7APZ5 Rv1829 Rv1829 AL450380.2 Mycobrowser_v4 CDS 2467991 2468746 . - 0 ML2075c ML2075c conserved hypothetical protein ML2075c, len: 251 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 26.4 kda protein Rv1828 SW:YI28_MYCTU (Q50605) fasta scores: E(): 0, 87.6% in 251 aa, and to Streptomyces coelicolor hypothetical 26.5 kda protein TR:CAB88879 (EMBL:AL353861) fasta scores: E(): 1.1e-14, 41.4% in 237 aa. Q7APZ4 No conserved hypotheticals PF00376 Q7APZ4 GO:0006355,GO:0003700,GO:0000166 Rv1828 Rv1828 AL450380.2 Mycobrowser_v4 CDS 2526817 2527789 . - 0 ML2126c ompA Outer membrane protein A OmpA (pseudogene) ML2126c, len: 973 bp. Possible pseudogene of M. tuberculosis orthologue ompA|Rv0899 (981 bp) (Best blastx scores: 201). Yes cell wall and cell processes Rv0899 Rv0899 AL450380.2 Mycobrowser_v4 CDS 2483351 2485298 . - 0 ML2089c ML2089c Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase and cyclase/dehydrase (pseudogene) ML2089c, len: 1948 bp. Possible pseudogene of M. tuberculosis orthologue Rv0939 (1935 bp) (Best blastx scores: 341). Yes intermediary metabolism and respiration Rv0939 Rv0939 AL450380.2 Mycobrowser_v4 CDS 2485298 2487357 . - 0 ML2090c ML2090c Possible ATP-dependent DNA ligase (pseudogene) ML2090c, len: 2060 bp. Possible pseudogene of M. tuberculosis orthologue Rv0938 (2280 bp) (Best blastx scores: 431). Yes information pathways Rv0938 Rv0938 AL450380.2 Mycobrowser_v4 CDS 2488231 2488863 . + 0 ML2092 mku Conserved hypothetical protein (pseudogene) ML2092, len: 633 bp. Possible pseudogene of M. tuberculosis orthologue Rv0937c (822 bp) (Best blastx scores: 333). Yes information pathways Rv0937c Rv0937c AL450380.2 Mycobrowser_v4 CDS 2509952 2510864 . + 0 ML2109 ML2109 Possible lipid carrier protein or keto acyl-CoA thiolase (pseudogene) ML2109, len: 913 bp. Possible pseudogene of M. tuberculosis orthologue Rv0914c (1239 bp) (Best blastx scores: 322). Yes lipid metabolism Rv0914c Rv0914c AL450380.2 Mycobrowser_v4 CDS 2510869 2512339 . + 0 ML2110 ML2110 Possible dioxygenase (pseudogene) ML2110, len: 1471 bp. Possible pseudogene of M. tuberculosis orthologue Rv0913c (1509 bp) (Best blastx scores: 498). Yes intermediary metabolism and respiration Rv0913c Rv0913c AL450380.2 Mycobrowser_v4 CDS 2519547 2520862 . + 0 ML2119 accD3 Putative acetyl-CoA carboxylase carboxyl transferase (beta subunit) accD3 (pseudogene) ML2119, len: 1316 bp. Possible pseudogene of M. tuberculosis orthologue accD3|Rv0904c (1488 bp) (Best blastx scores: 1142). Yes lipid metabolism Rv0904c Rv0904c AL450380.2 Mycobrowser_v4 CDS 2521027 2521374 . + 0 ML2120 ML2120 Conserved hypothetical protein (pseudogene) ML2120, len: 348 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins e.g. Rv1482c, Rv1073, Rv3517 and Rv3714c (Best blastx scores: 90). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2584418 2584591 . + 0 ML2173 ML2173 possible oxidoredutase (pseudogene) ML2173, len: 204 bp. Possible pseudogene similar to several possible oxidoredutase (Best blastx scores: 102). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2492523 2493297 . + 0 ML2096 ML2096 Probable short-chain dehydrogenase/reductase (pseudogene) ML2096, len: 775 bp. Possible pseudogene of M. tuberculosis orthologue Rv0927c (792 bp) (Best blastx scores: 352). Yes intermediary metabolism and respiration Rv0927c Rv0927c AL450380.2 Mycobrowser_v4 CDS 2495879 2496853 . - 0 ML2099c nrdZ Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (pseudogene) ML2099c, len: 975 bp. Possible pseudogene of M. tuberculosis orthologue nrdZ|Rv0570 (2079 bp) (Best blastx scores: 274). Yes information pathways Rv0570 Rv0570 AL450380.2 Mycobrowser_v4 CDS 2479849 2480992 . + 0 ML2086 ML2086 Putative group II intron maturase-related protein (pseudogene) ML2086, len: 1144 bp. Possible pseudogene, similar to several maturases e.g. Q9MD87|AF218567 putative maturase from Cryphonectria parasitica (Cheshnut blight fungus) (2334 bp), (blastx scores: 143); and Rv0071|O53616 Putative maturase from M. tuberculosis (705 bp), (blastx scores: 153). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2481257 2481355 . + 0 ML2087 ML2087 Possible transposase remnant (pseudogene) ML2087, len: 99 bp. Possible transposase remnant, similar to Q44454|Z18270 transposase from Agrobacterium tumefaciens (1098 bp), (blastx scores: 93); and to Q9R9U9|AJ245436 transposase tnpa1 from Pseudomonas putida (1065 bp), (blastx scores: 89). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2496927 2497147 . - 0 ML2100c ML2100c Conserved hypothetical protein (pseudogene) ML2100c, len: 221 bp. Possible pseudogene of M. tuberculosis orthologue Rv0569 (267 bp) (Best blastx scores: 68). Yes conserved hypotheticals Rv0569 Rv0569 AL450380.2 Mycobrowser_v4 CDS 2497617 2497907 . + 0 ML2101 ML2101 Conserved hypothetical protein (pseudogene) ML2101, len: 291 bp. Possible pseudogene similar to M. tuberculosis conserved hypothetical proteins e.g. Rv3134 and Rv2028c (Best blastx scores: 91). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2513877 2514422 . - 0 ML2113c ML2113c conserved hypothetical protein ML2113c, len: 181 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 15.8 kda protein Rv0910 TR:O05902 (EMBL:Z95210) fasta scores: E(): 0, 83.9% in 143 aa, and to Mycobacterium tuberculosis hypothetical 15.3 kda protein Rv1546 SW:YF46_MYCTU (Q10780) fasta scores: E(): 1e-19, 38.0% in 142 aa. Q50123 No conserved hypotheticals PF10604 Q50123 Rv0910 Rv0910 AL450380.2 Mycobrowser_v4 CDS 2547386 2548685 . + 0 ML2145 ML2145 Probable D-alanine, D-serine and glycine transporter (pseudogene) ML2145, len: 1300 bp. Possible pseudogene similar to M. tuberculosis cycA|Rv1704c (1671 bp) (Best blastx scores: 255). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2575695 2575908 . - 0 ML2166c ML2166c Conserved hypothetical protein (pseudogene) ML2166c, len: 214 bp. Possible pseudogene of M. tuberculosis orthologue Rv0854 (444 bp) (Best blastx scores: 131). Yes conserved hypotheticals Rv0854 Rv0854 AL450380.2 Mycobrowser_v4 CDS 2555423 2555751 . - 0 ML2152c moaE2 Probable molybdenum cofactor biosynthesis protein E2 MoaE2 (pseudogene) ML2152c, len: 329 bp. Possible pseudogene of M. tuberculosis orthologue moaE2|Rv0866 (426 bp) (Best blastx scores: 146). Yes intermediary metabolism and respiration Rv0866 Rv0866 AL450380.2 Mycobrowser_v4 CDS 2542627 2542902 . + 0 ML2141 ML2141 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN ML2141, len: 91 aa. Possible conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 9.5 kda protein Rv0879c SW:Y879_MYCTU (Q10541) fasta scores: E(): 6.6e-25, 76.9% in 91 aa. Contains membrane spanning domains. Q7APY5 No cell wall and cell processes PF10745 Q7APY5 Rv0879c Rv0879c AL450380.2 Mycobrowser_v4 CDS 2545680 2546168 . + 0 ML2144 ML2144 POSSIBLE CONSERVED EXPORTED PROTEIN ML2144, len: 162 aa. Possible conserved exported protein. Similar to Mycobacterium tuberculosis hypothetical 17.8 kda protein Rv0875c precursor SW:Y875_MYCTU (Q10537) fasta scores: E(): 0, 73.5% in 155 aa. Contains a possible N-terminal signal sequence. Q7APY3 No cell wall and cell processes Q7APY3 Rv0875c Rv0875c AL450380.2 Mycobrowser_v4 CDS 2556173 2556565 . - 0 ML2154c moaC2 Probable molybdenum cofactor biosynthesis protein C MoaC2 (pseudogene) ML2154c, len: 393 bp. Possible pseudogene of M. tuberculosis orthologue moaC2|Rv0864 (504 bp) (Best blastx scores: 177). Yes intermediary metabolism and respiration Rv0864 Rv0864 AL450380.2 Mycobrowser_v4 CDS 2562939 2563634 . - 0 ML2159c ML2159c Possible cytochrome P450 (pseudogene) ML2159c, len: 696 bp. Possible pseudogene similar to several M. tuberculosis probable cytochrome P450's e.g. cyp138|Rv0136, cyp137|Rv3685c and cyp139|Rv1666c (Best blastx scores: 82). Also similar to ML0447 from M. leprae. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2574461 2575455 . - 0 ML2165c far Probable fatty-acid-CoA racemase Far (pseudogene) ML2165c, len: 995 bp. Possible pseudogene of M. tuberculosis orthologue far|Rv0855 (1080 bp) (Best blastx scores: 434). Yes lipid metabolism Rv0855 Rv0855 AL450380.2 Mycobrowser_v4 CDS 2586584 2587007 . + 0 ML2175 ML2175 possible membrane protein (pseudogene) ML2175, len: 424 bp. Possible pseudogene similar to several M. tuberculosis membrane proteins e.g. Rv3728 and Rv3239c (Best blastx scores: 83). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2590100 2590763 . - 0 ML2179c ML2179c Conserved hypothetical protein (pseudogene) ML2179c, len: 664 bp. Possible pseudogene similar to M. tuberculosis Rv2308 (717 bp) (Best blastx scores: 240). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2595261 2595696 . + 0 ML2180 ML2180 Conserved hypothetical protein (pseudogene) ML2180, len: 436 bp. Possible pseudogene of M. tuberculosis orthologue Rv0831c (816 bp) (Best blastx scores: 117). Yes conserved hypotheticals Rv0831c Rv0831c AL450380.2 Mycobrowser_v4 CDS 2598377 2599024 . + 0 ML2184 ML2184 Conserved hypothetical protein (pseudogene) ML2184, len: 648 bp. Possible pseudogene of M. tuberculosis orthologue Rv0825c (642 bp) (Best blastx scores: 227). Yes conserved hypotheticals Rv0825c Rv0825c AL450380.2 Mycobrowser_v4 CDS 2556723 2556947 . - 0 ML2155c ML2155c conserved hypothetical protein ML2155c, len: 74 aa. Conserved hypothetical protein. Similar to C-terminus of Mycobacterium tuberculosis hypothetical protein Rv0863 TR:O53875 (EMBL:AL022004) fasta scores: E(): 1.5e-21, 74.0% in 73 aa. Q9CBE2 No conserved hypotheticals Q9CBE2 Rv0863 Rv0863 AL450380.2 Mycobrowser_v4 CDS 2561104 2561496 . - 0 ML2158c ML2158c hypothetical protein ML2158c, len: 130 aa. Hypothetical unknown protein. Q9CBD9 No unknown Q9CBD9 AL450380.2 Mycobrowser_v4 CDS 2583254 2583610 . + 0 ML2172 ML2172 hypothetical protein ML2172, len: 118 aa. Hypothetical unknown protein. Q9CBD4 No unknown Q9CBD4 AL450380.2 Mycobrowser_v4 CDS 2588194 2588451 . + 0 ML2176 ML2176 hypothetical protein ML2176, len: 85 aa. Hypothetical unknown protein. Q9CBD2 No unknown Q9CBD2 AL450380.2 Mycobrowser_v4 CDS 2640237 2641779 . + 0 ML2224 emrB Possible multidrug resistance integral membrane efflux protein EmrB (pseudogene) ML2224, len: 1543 bp. Possible pseudogene of M. tuberculosis orthologue Rv0783c|emrB (1623 bp) (Best blastx scores: 460). Also similar to ML1594c a possible pseudogene similar to M. tuberculosis emrB. Yes cell wall and cell processes Rv0783c Rv0783c AL450380.2 Mycobrowser_v4 CDS 2641817 2642375 . - 0 ML2225c ML2225c transcriptional regulatory protein (TetR family) (pseudogene) ML2225c, len: 559 nt. Possible pseudogene similar to several transcriptional regulators e.g. Q82HG3 Putative TetR-family transcriptional regulator from Streptomyces avermitilis (200 aa) (Best blastx score: 265) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2649932 2650557 . - 0 ML2232c ML2232c Conserved hypothetical protein (pseudogene) ML2232c, len: 626 bp. Possible pseudogene of M. tuberculosis orthologue Rv0775 (624 bp) (Best blastx scores: 161). Yes conserved hypotheticals Rv0775 Rv0775 AL450380.2 Mycobrowser_v4 CDS 2599223 2600239 . + 0 ML2185 desA1 CATALYZES THE PRINCIPAL CONVERSION OF SATURATED FATTY ACIDS TO UNSATURATED FATTY ACIDS. THOUGHT TO CONVERT STEAROYL-ACP TO OLEOYL-ACP BY INTRODUCTION OF A CIS DOUBLE BOND BETWEEN CARBONS DELTA-9 AND DELTA-10 OF THE ACYL CHAIN [CATALYTIC ACTIVITY: Stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + A + 2 H2O]. PROBABLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA1 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) (PROTEIN DES) ML2185, len: 338 aa. Probable desA1 acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.99.6). Similar to Mycobacterium tuberculosis protein desA1 Rv0824c TR:Q50824 (EMBL:U49839) fasta scores: E(): 0, 79.9% in 338 aa, and to Oryza sativa acyl-[acyl-carrier protein] desaturase precursor SW:STAD_ORYSA (Q40731) fasta scores: E(): 2e-19, 28.3% in 300 aa. Also similar to ML1952 from M. leprae. Q50050 No lipid metabolism PF03405 Q50050 GO:0006631,GO:0046914,GO:0045300 Rv0824c Rv0824c AL450380.2 Mycobrowser_v4 CDS 2609058 2609825 . - 0 ML2194c ML2194c Probable transcriptional regulatory protein (pseudogene) ML2194c, len: 768 bp. Possible pseudogene of M. tuberculosis orthologue Rv0818 (768 bp) (Best blastx scores: 209). Yes regulatory proteins Rv0818 Rv0818 AL450380.2 Mycobrowser_v4 CDS 2605136 2605756 . - 0 ML2190c ML2190c Probable phosphate-transport integral membrane ABC transporter (pseudogene) ML2190c, len: 621 bp. Possible pseudogene similar to M. tuberculosis pstA1|Rv0930 (927 bp) (Best blastx scores: 279), also similar to ML2093c a possible orthologue of M. tuberculosis pstA1 Yes unknown AL450380.2 Mycobrowser_v4 CDS 2609972 2610823 . + 0 ML2195 ML2195 PROBABLE CONSERVED EXPORTED PROTEIN ML2195, len: 283 aa. Probable conserved exported protein. Similar to Mycobacterium tuberculosis exported protein Rv0817c TR:O53829 (EMBL:AL022004) fasta scores: E(): 0, 73.0% in 270 aa. Contains a possible N-terminal signal sequence. Q7APX9 No cell wall and cell processes Q7APX9 Rv0817c Rv0817c AL450380.2 Mycobrowser_v4 CDS 2611551 2612036 . + 0 ML2197 ML2197 Possible integral membrane protein ML2197, len: 161 aa. Possible integral membrane protein, similar to Q54082|M29612 Saccharopolyspora erythraea hypothetical 16.0 kda protein (149 aa), fasta scores: E(): 4.9e-15, (43.9% in 139 aa). Contains possible membrane spanning hydrophobic domains. Q7APX8 No cell wall and cell processes Q7APX8 AL450380.2 Mycobrowser_v4 CDS 2610916 2611338 . + 0 ML2196 thiX PROBABLE THIOREDOXIN THIX ML2196, len: 140 aa. Probable thiX, thiredoxin. Similar to Mycobacterium tuberculosis putative thioredoxin Rv0816c TR:O53828 (EMBL:AL022004) fasta scores: E(): 1.1e-30, 63.8% in 141 aa, and to Anacystis nidulans thioredoxin 1 SW:THI1_ANANI (P12243) fasta scores: E(): 9e-07, 37.6% in 93 aa. Also similar to ML2703 from M. leprae. Contains PS00194 Thioredoxin family active site. Q9CBC8 No intermediary metabolism and respiration PF00085 Q9CBC8 GO:0045454 Rv0816c Rv0816c AL450380.2 Mycobrowser_v4 CDS 2600283 2601437 . + 0 ML2186 ML2186 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN ML2186, len: 384 aa. Possible transcriptional regulatory protein. Similar to Mycobacterium tuberculosis rv0823c SW:Y823_MYCTU transcriptional regulatory protein (O53835) fasta scores: E(): 0, 82.8% in 396 aa, and to Rhodobacter capsulatus nitrogen regulation protein NifR3 SW:NIR3_RHOCA (Q08111) fasta scores: E(): 2.6e-28, 34.0% in 332 aa. Contains Pfam match to entry PF01207 UPF0034, Uncharacterized protein family UPF0034. Contains PS01136 uncharacterized protein family UPF0034 signature. Q50049 No regulatory proteins PF01207 Q50049 GO:0055114,GO:0017150,GO:0008033,GO:0050660 1.-.-.- Rv0823c Rv0823c AL450380.2 Mycobrowser_v4 CDS 2631427 2632072 . + 0 ML2214 ML2214 Conserved hypothetical protein (pseudogene) ML2214, len: 646 bp. Possible pseudogene of M. tuberculosis orthologue Rv0799c (1008 bp) (Best blastx scores: 233). Yes conserved hypotheticals Rv0799c Rv0799c AL450380.2 Mycobrowser_v4 CDS 2632697 2633762 . + 0 ML2215 ML2215 Conserved hypothetical protein (pseudogene) ML2215, len: 1066 bp. Possible pseudogene similar to M. tuberculosis Rv3627c (1386 bp) (Best blastx scores: 258). Also similar to ML0211 a possible orthologue of M. tuberculosis Rv3627c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2637334 2637723 . + 0 ML2221 ML2221 Conserved hypothetical protein (pseudogene) ML2221, len: 390 bp. Possible pseudogene of M. tuberculosis orthologue Rv0786c (390 bp) (Best blastx scores: 194). Yes conserved hypotheticals Rv0786c Rv0786c AL450380.2 Mycobrowser_v4 CDS 2637792 2639307 . - 0 ML2222c ML2222c Conserved hypothetical protein (pseudogene) ML2222c, len: 1516 bp. Possible pseudogene of M. tuberculosis orthologue Rv0785 (1701 bp) (Best blastx scores: 559). Also similar to ML2122 a possible pseudogene similar to M. tuberculosis Rv0785. Yes conserved hypotheticals Rv0785 Rv0785 AL450380.2 Mycobrowser_v4 CDS 2639390 2639937 . - 0 ML2223c ML2223c Conserved hypothetical protein (pseudogene) ML2223c, len: 548 bp. Possible pseudogene of M. tuberculosis orthologue Rv0784 (687 bp) (Best blastx scores: 251). Yes conserved hypotheticals Rv0784 Rv0784 AL450380.2 Mycobrowser_v4 CDS 2870221 2870557 . + 0 ML2399 fadA3 Probable beta-ketoacyl CoA thiolase FadA3 (pseudogene) ML2399, len: 337 bp. Possible pseudogene of M. tuberculosis orthologue fadA3|Rv1074c (1218 bp) (Best blastx scores: 125). Yes lipid metabolism Rv1074c Rv1074c AL450380.2 Mycobrowser_v4 CDS 2650593 2651512 . + 0 ML2233 ML2233 Probable conserved exported protein (pseudogene) ML2233, len: 920 bp. Possible pseudogene of M. tuberculosis orthologue Rv0774c (912 bp) (Best blastx scores: 391). Yes cell wall and cell processes Rv0774c Rv0774c AL450380.2 Mycobrowser_v4 CDS 2645997 2646617 . + 0 ML2228 ML2228 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN ML2228, len: 206 aa. Possible conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 21.6 kda protein cy369.23c precursor Rv0779c OR MTCY369.23C TR:P71833 (EMBL:Z80226) fasta scores: E(): 0, 67.2% identity in 204 aa. Q7APX3 No cell wall and cell processes Q7APX3 Rv0779c Rv0779c AL450380.2 Mycobrowser_v4 CDS 2673656 2674432 . - 0 ML2250c ML2250c Probable short-chain alcohol dehydrogenase/reductase (pseudogene) ML2250c, len: 777 bp. Possible pseudogene of M. tuberculosis orthologue Rv3485c (945 bp) (Best blastx scores: 284). Yes intermediary metabolism and respiration Rv3485c Rv3485c AL450380.2 Mycobrowser_v4 CDS 2688582 2690085 . - 0 ML2266c fadD8 Probable fatty-acid-CoA ligase FadD8 (pseudogene) ML2266c, len: 1504 bp. Possible pseudogene of M. tuberculosis orthologue fadD8|Rv0551c (1716 bp) (Best blastx scores: 345). Yes lipid metabolism Rv0551c Rv0551c AL450380.2 Mycobrowser_v4 CDS 2690193 2691798 . + 0 ML2267 ML2267 Conserved hypothetical protein (pseudogene) ML2267, len: 1606 bp. Possible pseudogene of M. tuberculosis orthologue Rv0552 (1605 bp) (Best blastx scores: 526). Yes conserved hypotheticals Rv0552 Rv0552 AL450380.2 Mycobrowser_v4 CDS 2958132 2958525 . - 0 ML2483c ML2483c Conserved hypothetical protein (pseudogene) ML2483c, len: 394 bp. Possible pseudogene of M. tuberculosis orthologue Rv0372c (756 bp) (Best blastx scores: 190) Yes conserved hypotheticals Rv0372c Rv0372c AL450380.2 Mycobrowser_v4 CDS 2676326 2676541 . - 0 ML2253c ML2253c conserved hypothetical protein ML2253c, len: 71 aa. Conserved hypothetical protein, similar in part to AG84|WAG31|Rv2145c|MTCY270.23|AG84_MYCTU|P46816 Mycobacterium tuberculosis antigen 84 (260 aa), fasta scores: E(): 2.2e-05, 50.0% identity in 54 aa, and to ML0922|AG84|AG84_MYCLE|P46815 Mycobacterium leprae antigen 84, a possible orthologue of M. tuberculosis Rv2145c (266 aa), fasta scores: E(): 5.4e-05, 48.1% identity in 54 aa. Q7APW9 No conserved hypotheticals Q7APW9 AL450380.2 Mycobrowser_v4 CDS 2855475 2855848 . + 0 ML2384 ML2384 Conserved hypothetical protein (pseudogene) ML2384, len: 374 bp. Possible pseudogene of M. tuberculosis orthologue Rv0459 (492 bp) (Best blastx scores: 192). Yes conserved hypotheticals Rv0459 Rv0459 AL450380.2 Mycobrowser_v4 CDS 2682535 2682837 . - 0 ML2258c ML2258c conserved hypothetical protein ML2258c, len: 100 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0543c OR MTCY25D10.22C TR:O06409 (EMBL:Z95558) fasta scores: E(): 1.4e-27, 73.5% identity in 98 aa, and to Mycobacterium tuberculosis hypothetical 13.4 kda protein Rv3046c OR MTV012.61C TR:O53292 (EMBL:AL021287) fasta scores: E(): 6.8e-07, 35.9% identity in 103 aa. Q7APW7 No conserved hypotheticals Q7APW7 Rv0543c Rv0543c AL450380.2 Mycobrowser_v4 CDS 2698397 2698801 . - 0 ML2275c ML2275c Possible benzoquinone methyltransferase (pseudogene) ML2275c, len: 405 bp. Possible pseudogene of M. tuberculosis orthologue Rv0560c (726 bp) (Best blastx scores: 157). Yes intermediary metabolism and respiration Rv0560c Rv0560c AL450380.2 Mycobrowser_v4 CDS 2706841 2707322 . - 0 ML2282c ML2282c Conserved hypothetical protein (pseudogene) ML2282c, len: 482 bp. Possible pseudogene of M. tuberculosis orthologue Rv0566c (492 bp) (Best blastx scores: 377). Yes conserved hypotheticals Rv0566c Rv0566c AL450380.2 Mycobrowser_v4 CDS 2709385 2709931 . - 0 ML2285c ML2285c Probable conserved integral membrane protein (pseudogene) ML2285c, len: 547 bp. Possible pseudogene of M. tuberculosis orthologue Rv1986 (600 bp) (Best blastx scores: 161). Yes cell wall and cell processes Rv1986 Rv1986 AL450380.2 Mycobrowser_v4 CDS 2710039 2710847 . + 0 ML2286 ML2286 Probable transcriptional regulatory protein (LysR family) (pseudogene) ML2286, len: 809 bp. Possible pseudogene of M. tuberculosis orthologue Rv1985c (912 bp) (Best blastx scores: 238). Yes regulatory proteins Rv1985c Rv1985c AL450380.2 Mycobrowser_v4 CDS 2711144 2712272 . - 0 ML2287c ML2287c Possible oxidoreductase (pseudogene) ML2287c, len: 1129 bp. Possible pseudogene of M. tuberculosis orthologue Rv0575c (1167 bp) (Best blastx scores: 421). Yes intermediary metabolism and respiration Rv0575c Rv0575c AL450380.2 Mycobrowser_v4 CDS 2714203 2715822 . - 0 ML2290c dppD Probable dipeptide-transport ATP-binding protein ABC-transporter DppD (pseudogene) ML2290c, len: 1620 bp. Possible pseudogene of M. tuberculosis orthologue dppD|Rv3663c (1647 bp) (Best blastx scores: 822). Yes cell wall and cell processes Rv3663c Rv3663c AL450380.2 Mycobrowser_v4 CDS 2715865 2716663 . - 0 ML2291c dppC Probable dipeptide-transport integral membrane protein ABC-transporter DppC (pseudogene) ML2291c, len: 799 bp. Possible pseudogene of M. tuberculosis orthologue dppC|Rv3664c (801 bp) (Best blastx scores: 432). Yes cell wall and cell processes Rv3664c Rv3664c AL450380.2 Mycobrowser_v4 CDS 2716770 2717626 . - 0 ML2292c dppB Probable dipeptide-transport integral membrane protein ABC transporter DppB (pseudogene) ML2292c, len: 857 bp. Possible pseudogene of M. tuberculosis orthologue dppB|Rv3665c (927 bp) (Best blastx scores: 601). Yes cell wall and cell processes Rv3665c Rv3665c AL450380.2 Mycobrowser_v4 CDS 2717631 2718114 . - 0 ML2293c dppA Probable periplasmic dipeptide-binding lipoprotein DppA (pseudogene) ML2293c, len: 484 bp. Possible pseudogene of M. tuberculosis orthologue dppA|Rv3666c (1626 bp) (Best blastx scores: 304). Yes cell wall and cell processes Rv3666c Rv3666c AL450380.2 Mycobrowser_v4 CDS 2687465 2688076 . - 0 ML2264c ML2264c hypothetical protein ML2264c, len: 203 aa. Hypothetical unknown protein. Q9CBB4 No unknown Q9CBB4 AL450380.2 Mycobrowser_v4 CDS 2939185 2939751 . + 0 ML2465 ML2465 conserved hypothetical protein ML2465, len: 188 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 21.3 kda protein Rv0464c TR:O53749 (EMBL:AL021933) fasta scores: E(): 0, 67.4% id in 187 aa. Q9CB37 No conserved hypotheticals PF02627 Q9CB37 Rv0464c Rv0464c AL450380.2 Mycobrowser_v4 CDS 2695510 2696037 . + 0 ML2271 ML2271 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2271, len: 175 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis membrane protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 0, 79.2% identity in 168 aa. Contains hydrophobic, possible membrane-spanning regions. Q9CBA9 No cell wall and cell processes Q9CBA9 Rv0556 Rv0556 AL450380.2 Mycobrowser_v4 CDS 2698024 2698362 . - 0 ML2274c ML2274c POSSIBLE CONSERVED SECRETED PROTEIN ML2274c, len: 112 aa. Possible conserved secreted protein. Similar to Mycobacterium tuberculosis putative secreted protein Rv0559c or MTCY25D10.38C TR:O06425 (EMBL:Z95558) (112 aa) fasta scores: E(): 6.3e-32, 69.6% identity in 112 aa. Contains a probable N-terminal signal sequence. Q9CBA7 No cell wall and cell processes PF05305 Q9CBA7 Rv0559c Rv0559c AL450380.2 Mycobrowser_v4 CDS 2718836 2720521 . + 0 ML2294 acs Probable acetyl-CoA synthetase Acs (pseudogene) ML2294, len: 1686 bp. Possible pseudogene of M. tuberculosis orthologue acs|Rv3667 (1956 bp) (Best blastx scores: 303). Yes lipid metabolism Rv3667 Rv3667 AL450380.2 Mycobrowser_v4 CDS 2708445 2708804 . + 0 ML2284 ML2284 hypothetical protein ML2284, len: 119 aa. Hypothetical unknown protein. Q9CBA1 No unknown Q9CBA1 AL450380.2 Mycobrowser_v4 CDS 2713415 2714185 . - 0 ML2289c ML2289c conserved hypothetical protein ML2289c, len: 256 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv3662c or MTV025.010C TR:O69630 (EMBL:AL022121) (256 aa) fasta scores: E(): 0, 78.0% identity in 255 aa and to Streptomyces coelicolor putative oxidoreductase SCH5.22C TR:Q9X924 (EMBL:AL035636) (274 aa) fasta scores: E(): 1e-11, 40.9% identity in 269 aa. Q9CB99 No conserved hypotheticals Q9CB99 Rv3662c Rv3662c AL450380.2 Mycobrowser_v4 CDS 2745157 2745445 . - 0 ML2317c ML2317c Conserved hypothetical protein (pseudogene) ML2317c, len: 289 bp. Possible pseudogene of M. tuberculosis orthologue Rv3700c (1173 bp) (Best blastx scores: 121). Yes intermediary metabolism and respiration Rv3700c Rv3700c AL450380.2 Mycobrowser_v4 CDS 2958712 2959377 . + 0 ML2484 ML2484 Probable transcriptional regulatory protein (LysR family) (pseudogene) ML2484, len: 666 bp. Possible pseudogene of M. tuberculosis orthologue Rv0377 (966 bp) (Best blastx scores: 299). Yes regulatory proteins Rv0377 Rv0377 AL450380.2 Mycobrowser_v4 CDS 2855977 2856218 . + 0 ML2385 ML2385 Conserved hydrophobic protein (pseudogene) ML2385, len: 242 bp. Possible pseudogene of M. tuberculosis orthologue Rv0460 (240 bp) (Best blastx scores: 182). Yes conserved hypotheticals Rv0460 Rv0460 AL450380.2 Mycobrowser_v4 CDS 2850490 2850951 . - 0 ML2380c ML2380c possible secreted protein ML2380c, len: 153 aa. Possible secreted protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0455c TR:O53740 (EMBL:AL021932) (148 aa) fasta scores: E(): 0, 66.4% id in 152 aa. Contains a possible N-terminal signal sequence. Q9CB68 No cell wall and cell processes, conserved hypotheticals Q9CB68 Rv0455c Rv0455c AL450380.2 Mycobrowser_v4 CDS 2741820 2743346 . - 0 ML2314c glpK PROBABLE GLYCEROL KINASE GLPK (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK) ML2314c, len: 508 aa. Probable glpK, glycerol kinase (EC 2.7.1.30). Similar to Mycobacterium tuberculosis glycerol kinase Rv3696c SW:GLPK_MYCTU (O69664) (517 aa) fasta scores: E(): 0, 91.5% identity in 508 aa and Escherichia coli glycerol kinase SW:GLPK_ECOLI (P08859; Q59381) (501 aa) fasta scores: E(): 0, 51.4% id in 500 aa. Contains Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases. Contains PS00445 FGGY family of carbohydrate kinases signature 2. Contains PS00933 FGGY family of carbohydrate kinases signature 1. Q9CB81 No intermediary metabolism and respiration PF00370,PF02782 Q9CB81 GO:0005975,GO:0004370,GO:0006072,GO:0005524 2.7.1.30 Rv3696c Rv3696c AL450380.2 Mycobrowser_v4 CDS 2782755 2782982 . + 0 ML2343 ML2343 Probable L-asparaginase (pseudogene) ML2343, len: 228 bp. Possible pseudogene similar to M. tuberculosis ansA|Rv1538c (981 bp) (Best blastx scores: 107), also similar to ML1198c a possible orthologue of M. tuberculosis ansA. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2763022 2764401 . + 0 ML2333 ML2333 conserved hypothetical protein ML2333, len: 459 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 53.0 kDa protein Rv3719 TR:O69686 (EMBL:AL022121) (470 aa) fasta scores: E(): 0, 82.8% identity in 458 aa. Q7APW3 No conserved hypotheticals PF01565 Q7APW3 GO:0016491,GO:0050660 Rv3719 Rv3719 AL450380.2 Mycobrowser_v4 CDS 2750475 2751485 . - 0 ML2321c ML2321c conserved hypothetical protein ML2321c, len: 336 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 36.5 kDa protein Rv3707c TR:O69675 (EMBL:AL022121) (336 aa) fasta scores: E(): 0, 81.6% identity in 332 aa, and to Mycobacterium smegmatis hypothetical 35.9 kDa protein in asd 3'region SW:YASD_MYCSM (P41402) (333 aa) fasta scores: E(): 0, 70.8% identity in 332 aa. Q9CB79 No conserved hypotheticals Q9CB79 Rv3707c Rv3707c AL450380.2 Mycobrowser_v4 CDS 2757748 2758983 . + 0 ML2326 ML2326 possible ligase ML2326, len: 411 aa. Possible ligase (EC 6.-.-.-). Similar to several MurCDEF-family proteins e.g. Mycobacterium tuberculosis UDP-N-acetylmuramate--alanine ligase Rv2152c SW:MURC_MYCTU (O06225) (494 aa) fasta scores: E(): 0.0013, 25.6% identity in 387 aa. Also highly similar to Mycobacterium tuberculosis hypothetical 43.4 kDa protein Rv3712 TR:O69679 (EMBL:AL022121) (413 aa) fasta scores: E(): 0, 84.3% id in 413 aa. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Q7APW6 No intermediary metabolism and respiration PF08245,PF08353 Q7APW6 GO:0009058,GO:0016874,GO:0005524 Rv3712 Rv3712 AL450380.2 Mycobrowser_v4 CDS 2868744 2869475 . + 0 ML2398 ML2398 Conserved exported protein (pseudogene) ML2398, len: 732 bp. Possible pseudogene of M. tuberculosis orthologue Rv1075c (945 bp) (Best blastx scores: 209). Yes cell wall and cell processes Rv1075c Rv1075c AL450380.2 Mycobrowser_v4 CDS 2787103 2788008 . - 0 ML2346c ML2346c conserved hypothetical protein ML2346c, len: 301 aa. Conserved hypothetical protein. Weakly similar to other hypothetical proteins e.g. Q89ZU5 Conserved hypothetical protein from Bacteroides thetaiotaomicron (277 aa), fasta scores: E(): 1.3e-15, (31.319% identity in 182 aa overlap). Note the G+C content of this CDS (54%). Q49942 No conserved hypotheticals Q49942 AL450380.2 Mycobrowser_v4 CDS 2827250 2828463 . + 0 ML2362 tcrY Possible two component sensor kinase TcrY (pseudogene) ML2362, len: 1214 bp. Possible pseudogene of M. tuberculosis orthologue Rv3764c|tcrY (1428 bp) (Best blastx scores: 287). Yes regulatory proteins Rv3764c Rv3764c AL450380.2 Mycobrowser_v4 CDS 2836814 2837663 . - 0 ML2369c PPE PPE-family protein (pseudogene) ML2369c, len: 850 bp. Possible pseudogene of M. tuberculosis orthologue PPE10|Rv0442c (1464 bp) (Best blastx scores: 122). Yes PE/PPE Rv0442c Rv0442c AL450380.2 Mycobrowser_v4 CDS 2839691 2840021 . - 0 ML2370c sigK Probable alternative RNA polymerase sigma factor SigK (pseudogene) ML2370c, len: 331 bp. Possible pseudogene of M. tuberculosis orthologue sigK|Rv0445c (564 bp) (Best blastx scores: 94). Yes information pathways Rv0445c Rv0445c AL450380.2 Mycobrowser_v4 CDS 2840695 2841555 . - 0 ML2372c ufaA1 Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (pseudogene) ML2372c, len: 861 bp. Possible pseudogene of M. tuberculosis orthologue ufaA1|Rv0447c (1284 bp) (Best blastx scores: 142). Yes lipid metabolism Rv0447c Rv0447c AL450380.2 Mycobrowser_v4 CDS 2845418 2846089 . - 0 ML2376c ML2376c Possible transcriptional regulatory protein (pseudogene) ML2376c, len: 672 bp. Possible pseudogene of M. tuberculosis orthologue Rv0452 (711 bp0 (Best blastx scores: 398). Yes regulatory proteins Rv0452 Rv0452 AL450380.2 Mycobrowser_v4 CDS 2859666 2861320 . - 0 ML2389c ML2389c Conserved hypothetical protein (pseudogene) ML2389c, len: 1655 bp. Possible pseudogene of M. tuberculosis orthologue Rv1084 (2022 bp) (Best blastx scores: 325). Yes conserved hypotheticals Rv1084 Rv1084 AL450380.2 Mycobrowser_v4 CDS 2867413 2868277 . - 0 ML2397c ML2397c Possible lipase (pseudogene) ML2397c, len: 865 bp. Possible pseudogene similar to M. tuberculosis lipU|Rv1076 (894 bp) (Best blastx scores: 548), a orthologue of lipU exist in M. leprae at ML0314c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2861307 2861612 . - 0 ML2390c ML2390c Conserved membrane protein ML2390c, len: 101 aa. Conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1083 TR:O53431 (EMBL:AL021897) (88 aa) fasta scores: E(): 4.9e-15, 57.4% identity in 101 aa. Contains a possible membrane spanning domain. Q9CB67 No cell wall and cell processes, conserved hypotheticals Q9CB67 Rv1083 Rv1083 AL450380.2 Mycobrowser_v4 CDS 2811478 2816100 . - 0 ML2356c ppsB PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB ML2356c, len: 1540 aa. Probable ppsB, type-I polyketide synthase. Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% identity in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% identity in 879 aa. Also similar to ML2353, ML2354, ML0139, ML0135, ML2354, ML2355, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q7APV9 No lipid metabolism PF00109,PF00550,PF00698,PF02801,PF08659 Q7APV9 GO:0009058,GO:0048037,GO:0016740,GO:0000036 Rv2932 Rv2932 AL450380.2 Mycobrowser_v4 CDS 3035417 3036264 . + 0 ML2547 ML2547 Conserved hypothetical protein (pseudogene) ML2547, len: 848 bp. Possible pseudogene of M. tuberculosis orthologue Rv0269c (1194 bp) (Best blastx scores: 255). Yes conserved hypotheticals Rv0269c Rv0269c AL450380.2 Mycobrowser_v4 CDS 2872838 2873611 . + 0 ML2402 echA8 PROBABLE ENOYL-CoA HYDRATASE ECHA8 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) ML2402, len: 257 aa. Probable echA8, enoyl-CoA hydratase (EC 4.2.1.17). Similar to Mycobacterium tuberculosis probable enoyl-CoA hydratase Rv1070c SW:ECH8_MYCTU (O53418) (257 aa) fasta scores: E(): 0, 86.4% identity in 257 aa, and to Rhizobium meliloti probable enoyl-CoA hydratase SW:ECHH_RHIME (Q52995) (257 aa) fasta scores: E(): 0, 67.3% identity in 257 aa. Also similar to ML1724 from M. leprae. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. O07137 No lipid metabolism PF00378 O07137 GO:0006631,GO:0004300 4.2.1.17 Rv1070c Rv1070c AL450380.2 Mycobrowser_v4 CDS 2891481 2892354 . + 0 ML2417 ML2417 Possible conserved membrane protein (pseudogene) ML2417, len: 874 bp. Possible pseudogene of M. tuberculosis orthologue Rv0519c (903 bp) (Best blastx scores: 337). Yes cell wall and cell processes Rv0519c Rv0519c AL450380.2 Mycobrowser_v4 CDS 2881028 2882656 . - 0 ML2410c ML2410c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2410c, len: 542 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0528 TR:O06394 (EMBL:Z95558) (529 aa) fasta scores: E(): 0, 80.9% identity in 530 aa. Contains multiple possible membrane spanning hydrophobic domains. Q9CB62 No cell wall and cell processes PF05140 Q9CB62 Rv0528 Rv0528 AL450380.2 Mycobrowser_v4 CDS 2923927 2924459 . + 0 ML2448 ML2448 Hypothetical protein (pseudogene) ML2448, len: 533 bp. Possible pseudogene of M. tuberculosis orthologue Rv0481c (525 bp) (Best blastx scores: 147). Yes conserved hypotheticals Rv0481c Rv0481c AL450380.2 Mycobrowser_v4 CDS 2920673 2921404 . + 0 ML2445 ML2445 Probable short-chain type oxidoreductase (pseudogene) ML2445, len: 732 bp. Possible pseudogene of M. tuberculosis orthologue Rv0484c (756 bp) (Best blastx scores: 429). Yes intermediary metabolism and respiration Rv0484c Rv0484c AL450380.2 Mycobrowser_v4 CDS 2906428 2907108 . - 0 ML2431c ML2431c Conserved hypothetical protein (pseudogene) ML2431c, len: 681 bp. Possible pseudogene of M. tuberculosis orthologue Rv0499 (876 bp) (Best blastx scores: 235). Yes conserved hypotheticals Rv0499 Rv0499 AL450380.2 Mycobrowser_v4 CDS 2305210 2305527 . + 0 ML1922 ML1922 conserved hypothetical protein TB11.2 homolog ML1922, len: 105 aa. Conserved hypothetical protein. Similar to M. tuberculosis conserved hypothetical protein Rv3592 TR:O06156 (EMBL:Z95555) (105 aa), Fasta scores: E(): 0, 84.6% identity in 104 aa overlap, and to others e.g. Bacillus subtilis hypothetical protein SW:YHGC_BACSU (L10630) (166 aa), Fasta scores: E(): 5.2e-06, 40.8% identity in 71 aa overlap. Q9CBI8 No conserved hypotheticals, intermediary metabolism and respiration PF03992 Q9CBI8 GO:0005737,GO:0016491,GO:0017000 Rv3592 Rv3592 AL450380.2 Mycobrowser_v4 CDS 2911959 2912591 . + 0 ML2437 ML2437 Conserved hypothetical protein (pseudogene) ML2437, len: 633 bp. Possible pseudogene of M. tuberculosis orthologue Rv0493c (990 bp) (Best blastx scores: 121). Yes conserved hypotheticals Rv0493c Rv0493c AL450380.2 Mycobrowser_v4 CDS 3109201 3109707 . + 0 ML2605 ML2605 conserved hypothetical protein ML2605, len: 168 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0185 TR:O07429 (EMBL:Z97050) fasta scores: E(): 0, 76.4% identity in 165 aa. Q7APT5 No conserved hypotheticals Q7APT5 Rv0185 Rv0185 AL450380.2 Mycobrowser_v4 CDS 3039200 3039748 . + 0 ML2551 aac AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE AAC (AAC(2')-IC) ML2551, len: 182 aa. aac, aminoglycoside 2'-N-acetyltransferase (EC 2.3.1.-). Highly similar to several mycobacterial aminoglycoside-resistance determinants e.g. Mycobacterium tuberculosis aminoglycoside 2'-n-acetyltransferase Aac OR Rv0262c SW:AAC2_MYCTU (P95219; P72033) fasta scores: E(): 0, 78.7% identity in 178 aa. Q9CD24 No virulence, detoxification, adaptation PF00583 Q9CD24 GO:0008152,GO:0008080 Rv0262c Rv0262c AL450380.2 Mycobrowser_v4 CDS 2195139 2197973 . + 0 ML1814 acn PROBABLE IRON-REGULATED ACONITATE HYDRATASE ACN (Citrate hydro-lyase) (Aconitase) ML1814, len: 944 aa. Probable acn, iron-regulated aconitate hydratase (EC 4.2.1.3). Similar to M. tuberculosis aconitate hydratase Rv1475c TR:O53166 (EMBL:AL021184) (943 aa), Fasta scores: E(): 0, 86.8% identity in 948 aa overlap, and to many others e.g. Bacillus subtilis aconitate hydratase SW:ACON_BACSU (P09339) (908 aa), Fasta scores: E(): 0, 51.1% identity in 940 aa overlap. Also similar to ML1685 from M. leprae. Contains 2 Pfam matches to entry PF00330 aconitase, Aconitase family (aconitate hydratase). Contains Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain. Contains PS01244 Aconitase family signature 2. Contains PS00450 Aconitase family signature 1. Q9CBL3 No intermediary metabolism and respiration PF00330,PF00694 Q9CBL3 GO:0008152,GO:0051539 Rv1475c Rv1475c AL450380.2 Mycobrowser_v4 CDS 2912665 2912931 . + 0 ML2437A ML2437A Conserved hypothetical protein ML2437A, len: 267 bp. Possible pseudogene similar to M. tuberculosis Rv0492A (330 bp) (Best blastx scores: 98) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2955114 2956288 . - 0 ML2479c ML2479c Conserved hypothetical protein (pseudogene) ML2479c, len: 1175 bp. Possible pseudogene of M. tuberculosis orthologue Rv0368c (1212 bp) (Best blastx scores: 326). Yes conserved hypotheticals Rv0368c Rv0368c AL450380.2 Mycobrowser_v4 CDS 3030294 3031396 . + 0 ML2544 ML2544 Hypothetical protein (pseudogene) ML2544, len: 1103 bp. Possible pseudogene of M. tuberculosis orthologue Rv0272c (1134 bp) (Best blastx scores: 474). Yes conserved hypotheticals Rv0272c Rv0272c AL450380.2 Mycobrowser_v4 CDS 2936759 2937553 . - 0 ML2463c ML2463c conserved hypothetical protein ML2463c, len: 264 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 30.2 kda protein Rv0466 TR:O53751 (EMBL:AL021933) fasta scores: E(): 0, 87.1% id in 264 aa. Q9CB38 No conserved hypotheticals PF01643 Q9CB38 GO:0006633,GO:0000036 Rv0466 Rv0466 AL450380.2 Mycobrowser_v4 CDS 2882653 2883441 . - 0 ML2411c ccdA POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCDA ML2411c, len: 262 aa. possible ccdA, cytochrome C-type biogenesis protein. Similar to Mycobacterium tuberculosis cytochrome C-type biogenesis protein Rv0527 TR:O06393 (EMBL:Z95558) (259 aa) fasta scores: E(): 0, 79.0% identity in 262 aa, and to Bacillus subtilis cytochrome C-type biogenesis protein SW:CCDA_BACSU (P45706) (235 aa) fasta scores: E(): 9e-08, 28.9% identity in 242 aa. Contains multiple possible membrane spanning hydrophobic domains. Q7APV0 No intermediary metabolism and respiration PF02683 Q7APV0 GO:0016020,GO:0017004 Rv0527 Rv0527 AL450380.2 Mycobrowser_v4 CDS 3215952 3216359 . + 0 ML2674 ML2674 Probable glutamine-transport transmembrane protein ABC transporter (pseudogene) ML2674, len: 408 bp. Possible pseudogene of M. tuberculosis orthologue Rv2563 (1050 bp) (Best blastx scores: 212) and also similar to Rv0072. Yes cell wall and cell processes Rv2563 Rv2563 AL450380.2 Mycobrowser_v4 CDS 2044342 2046219 . - 0 ML1696c ilvB PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) ML1696c, len: 625 aa. Probable ilvB, acetolactate synthase I large subunit (EC 4.1.3.18). Highly similar to many acetolactate synthases, large subunit, involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVB_MYCAV (Q59498) (621 aa), Fasta scores: E(): 0, 82.7% identity in 624 aa overlap and Mycobacterium tuberculosis Rv3003c SW:ILVB_MYCTU (O53250) (618 aa), Fasta scores: E(): 0, 87.1% identity in 627 aa overlap. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature. O33112 No intermediary metabolism and respiration PF00205,PF02775,PF02776 O33112 GO:0003984,GO:0009082,GO:0000287,GO:0030976,GO:0050660 2.2.1.6 Rv3003c Rv3003c AL450380.2 Mycobrowser_v4 CDS 2391324 2393576 . - 0 ML2000c ctpB PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB ML2000c, len: 750 aa. Probable ctpB, cation-transporter P-type ATPase B (EC 3.6.3.-). Similar to M. tuberculosis cation-transporting ATPase ctpB SW:CTPB_MYCTU (Q10877) (752 aa), Fasta scores: E(): 0, 77.0% identity in 752 aa overlap, and to many others e.g. Bacillus subtilis potential copper-transporting ATPase YVGX SW:ATCU_BACSU (O32220) (803 aa), Fasta scores: E(): 0, 39.8% identity in 744 aa overlap. Also similar to ML1987, ML0747 and ML2671 from M. leprae. Contains Pfam matches to entries PF00403 HMA, Heavy-metal-associated domain and PF00122 E1-E2_ATPase, E1-E2 ATPase. Also contains Prosite hits to PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00154 E1-E2 ATPases phosphorylation site, PS01047 Heavy-metal-associated domain and PS01229 Hypothetical cof family signature 2. Contains multiple possible membrane spanning hydrophobic domains. P46840 No cell wall and cell processes PF00122,PF00403,PF00702 P46840 GO:0006754,GO:0004008,GO:0016021,GO:0000287,GO:0030001,GO:0005886,GO:0005524 3.6.3.- Rv0103c Rv0103c AL450380.2 Mycobrowser_v4 CDS 3144581 3145051 . - 0 ML2629c ML2629c CONSERVED HYPOTHETICAL PROTEIN TB18.5 HOMOLOG ML2629c, len: 156 aa. Conserved hypothetical protein. Similar to a number of proteins of undefined function e.g. Mycobacterium tuberculosis Rv0164 (161 aa), fasta scores: E(): 3.8e-47, (76.316% identity in 152 aa overlap). Also similar to ML0124 from M. leprae. Q7APS8 No conserved hypotheticals PF03364 Q7APS8 Rv0164 Rv0164 AL450380.2 Mycobrowser_v4 CDS 3127775 3128658 . + 0 ML2619 ML2619 Probable conserved transmembrane protein (pseudogene) ML2619, len: 884 bp. Possible pseudogene of M. tuberculosis orthologue Rv0205 (1104 bp) (Best blastx scores: 244). Yes cell wall and cell processes Rv0205 Rv0205 AL450380.2 Mycobrowser_v4 CDS 3089691 3090465 . + 0 ML2586 fadD5 Probable fatty-acid-CoA synthase FadD5 (pseudogene) ML2586, len: 775 bp. Possible pseudogene of M. tuberculosis orthologue fadD5|Rv0166 (165 bp) (Best blastx scores: 184). Also similar to ML2628c a possible pseudogene similar to M. tuberculosis fadD5. Yes lipid metabolism Rv0166 Rv0166 AL450380.2 Mycobrowser_v4 CDS 3162742 3163654 . + 0 ML2643 ML2643 Probable conserved transmembrane protein (pseudogene) ML2643, len: 913 bp. Possible pseudogene of M. tuberculosis orthologue Rv0143c (1479 bp) (Best blastx scores: 262). Yes cell wall and cell processes Rv0143c Rv0143c AL450380.2 Mycobrowser_v4 CDS 2065087 2065887 . - 0 ML1712c fixA PROBABLE ELECTRON TRANSFER FLAVOPROTEIN (BETA-SUBUNIT) FIXA (BETA-ETF) (ELECTRON TRANSFER FLAVOPROTEIN SMALL SUBUNIT) (ETFSS) ML1712c, len: 266 aa. Probable fixA (alternate gene name: etfB), electron transfer flavoprotein (beta-subunit). Highly similar to many electron transfer flavoprotein beta-subunits, including: Megasphaera elsdenii SW:ETFB_MEGEL (O85691) (270 aa), Fasta scores: E(): 1.5e-25, 36.1% identity in 274 aa overlap and Mycobacterium tuberculosis Rv3029c SW:ETFB_MYCTU (O53276) (266 aa), Fasta scores: E(): 0, 95.1% identity in 266 aa overlap. Contains Pfam match to entry PF01012 ETF_beta, Electron transfer flavoprotein beta subunit. NOte previously known as eftB. O33095 No intermediary metabolism and respiration PF01012 O33095 GO:0022900,GO:0006810,GO:0009055 Rv3029c Rv3029c AL450380.2 Mycobrowser_v4 CDS 3086333 3087142 . + 0 ML2584 ML2584 POSSIBLE METHYLTRANSFERASE (METHYLASE) ML2584, len: 269 aa. Possible methyltransferase (EC 2.1.1.-). Similar to Mycobacterium tuberculosis hypothetical protein Rv0224c TR:P96406 (EMBL:Z92669) fasta scores: E(): 0, 82.9% identity in 252 aa. Also weakly to several putative methyltransferases e.g. Synechocystis sp sterol-C-methyltransferase TR:P74388 (EMBL:D90914) fasta scores: E(): 7.4e-06, 31.1% identity in 135 aa. O69492 No intermediary metabolism and respiration PF08241 O69492 GO:0008168,GO:0008152 Rv0224c Rv0224c AL450380.2 Mycobrowser_v4 CDS 3165197 3166134 . - 0 ML2645c ML2645c Possible oxidoreductase (pseudogene) ML2645c, len: 938 bp. Possible pseudogene of M. tuberculosis orthologue Rv0139 (1023 bp) (Best blastx scores: 248). Yes intermediary metabolism and respiration Rv0139 Rv0139 AL450380.2 Mycobrowser_v4 CDS 2961955 2962152 . - 0 ML2488c ML2488c Possible ketoacyl reductase (pseudogene) ML2488c, len: 198 bp. Possible pseudogene similar to M. tuberculosis Rv1544 (804 bp) (Best blastx scores: 86). Also similar to ML1205 a possible pseudogene similar to M. tuberculosis Rv1544. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2986701 2987418 . - 0 ML2506c udgA Probable UDP-glucose 6-dehydrogenase UdgA (pseudogene) ML2506c, len: 718 bp. Possible pseudogene of M. tuberculosis orthologue udgA|Rv0322 (1332 bp) (Best blastx scores: 398). Yes intermediary metabolism and respiration Rv0322 Rv0322 AL450380.2 Mycobrowser_v4 CDS 2946640 2947197 . + 0 ML2471 ML2471 Conserved hypothetical protein (pseudogene) ML2471, len: 558 bp. Possible pseudogene of M. tuberculosis orthologue Rv3755c (600 bp) (Best blastx scores: 319). Yes conserved hypotheticals Rv3755c Rv3755c AL450380.2 Mycobrowser_v4 CDS 2537503 2538528 . - 0 ML2135c ML2135c possible transmembrane protein ML2135c, len: 341 aa. Possible transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 39.8 kda protein Rv0885 SW:Y885_MYCTU (Q10546) fasta scores: E(): 0, 83.9% in 341 aa, and to Streptomyces coelicolor putative membrane protein TR:Q9XAE8 (EMBL:AL079356) fasta scores: E(): 1.5e-13, 27.1% in 255 aa. Contains possible membrane spanning hydrophobic domains. Q7APY7 No cell wall and cell processes, conserved hypotheticals Q7APY7 GO:0016021 Rv0885 Rv0885 AL450380.2 Mycobrowser_v4 CDS 1936170 1937039 . - 0 ML1612c lepB PROBABLE SIGNAL PEPTIDASE I LEPB (SPASE I) (LEADER PEPTIDASE I). ML1612c, len: 289 aa. Probable lepB, signal peptidase I (EC 3.4.21.89). Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa), Fasta scores: E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis Rv2903c SW:LEP_MYCTU (Q1078) (294 aa), Fasta scores: E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. O33021 No cell wall and cell processes PF00717 O33021 GO:0005886,GO:0006508,GO:0008236,GO:0016021 3.4.21.89 Rv2903c Rv2903c AL450380.2 Mycobrowser_v4 CDS 3004598 3005254 . - 0 ML2522c ML2522c POSSIBLE CONSERVED EXPORTED PROTEIN ML2522c, len: 218 aa. Possible conserved secreted protein. Similar to Mycobacterium tuberculosis exported protein Rv0309 TR:O07236 (EMBL:Z96800) fasta scores: E(): 0, 78.0% identity in 218 aa, and to Streptomyces coelicolor putative secreted protein SCL24.08 TR:CAB76092 (EMBL:AL157956) fasta scores: E(): 2.8e-13, 32.4% identity in 207 aa. Contains a possible N-terminal signal sequence. Q9CD38 No cell wall and cell processes PF03734 Q9CD38 Rv0309 Rv0309 AL450380.2 Mycobrowser_v4 CDS 2968018 2968799 . + 0 ML2492 ML2492 Probable monooxygenase (pseudogene) ML2492, len: 782 bp. Possible pseudogene of M. tuberculosis orthologue Rv0385 (1173 bp) (Best blastx scores: 159). Yes intermediary metabolism and respiration Rv0385 Rv0385 AL450380.2 Mycobrowser_v4 CDS 3171332 3172487 . - 0 ML2650c ML2650c Conserved hypothetical membrane protein (pseudogene) ML2650c, len: 1156 bp. Possible pseudogene similar to M. tuberculosis Rv1639c (1470 bp) (Best blastx scores: 321). Yes unknown AL450380.2 Mycobrowser_v4 CDS 3062388 3062867 . + 0 ML2567 ML2567 hypothetical protein ML2567, len: 159 aa. Hypothetical unknown protein. Q9CD21 No unknown Q9CD21 AL450380.2 Mycobrowser_v4 CDS 2948280 2948759 . + 0 ML2473 ML2473 conserved hypothetical protein ML2473, len: 159 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv3753c TR:O69720 (EMBL:AL022121) fasta scores: E(): 0, 88.3% identity in 163 aa. Q9CB33 No conserved hypotheticals Q9CB33 Rv3753c Rv3753c AL450380.2 Mycobrowser_v4 CDS 2349996 2350481 . + 0 ML1966 lpqH POSSIBLE 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR LPQH ML1966, len: 161 aa. Possible lpqH, Lipoprotein antigen precutsor. Similar to M. tuberculosis 19 kDa lipoprotein antigen precursor lpqH Rv3763. Contains a possible N-terminal signal sequence and a PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9X7A5 No cell wall and cell processes PF05481 Q9X7A5 GO:0016020 Rv3763 Rv3763 AL450380.2 Mycobrowser_v4 CDS 2942035 2942415 . - 0 ML2468c ML2468c hypothetical protein ML2468c, len: 126 aa. Hypothetical unknown protein. Q9CB35 No unknown Q9CB35 AL450380.2 Mycobrowser_v4 CDS 2013063 2013911 . + 0 ML1669 ML1669 PROBABLE OXIDOREDUCTASE ML1669, len: 282 aa. Probable oxidoreductase of Aldo/keto reductase family. Highly similar to many putative oxidoreductases including: Escherichia coli SW:YQHE_ECOLI (Q46857) (275 aa), Fasta scores: E(): 0, 46.1% identity in 271 aa overlap and Mycobacterium tuberculosis Rv2971 TR:P95124 (EMBL:Z83018) (282 aa), Fasta scores: E(): 0, 79.8% identity in 282 aa overlap. Contains Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase family. Contains PS00062 Aldo/keto reductase family signature 2. O69462 No intermediary metabolism and respiration PF00248 O69462 GO:0016491,GO:0055114 Rv2971 Rv2971 AL450380.2 Mycobrowser_v4 CDS 2911089 2911811 . - 0 ML2436c ML2436c Probable transcriptional regulatory protein (GntR family) (pseudogene) ML2436c, len: 723 bp. Possible pseudogene of M. tuberculosis orthologue Rv0494 (729 bp) (Best blastx scores: 276). Yes regulatory proteins Rv0494 Rv0494 AL450380.2 Mycobrowser_v4 CDS 2940008 2940689 . - 0 ML2466c ML2466c Possible hemolysin-like protein (pseudogene) ML2466c, len: 682 bp. Possible pseudogene of M. tuberculosis orthologue Rv1085c (729 bp) (Best blastx scores: 150). Yes virulence, detoxification, adaptation Rv1085c Rv1085c AL450380.2 Mycobrowser_v4 CDS 2960112 2960948 . - 0 ML2486c ML2486c Hypothetical protein (pseudogene) ML2486c, len: 837 bp. Possible pseudogene of M. tuberculosis orthologue Rv0381c (Best blastx scores: 524). Yes conserved hypotheticals Rv0381c Rv0381c AL450380.2 Mycobrowser_v4 CDS 2159152 2160120 . - 0 ML1783c ML1783c Possible transcriptional regulatory protein ML1783c, len: 322 aa. Possible transcriptional regulatory protein. Similar to M. tuberculosis Rv2258c TR:O53532 (EMBL:AL021925) (353 aa), Fasta scores: E(): 0, 65.2% identity in 273 aa overlap but shorter at N-terminus and frameshifted near C-terminus. Also similar to some C. elegans proteins e.g. TR:O01593 (EMBL:U97004) (365 aa), Fasta scores: E(): 7.5e-17, 25.1% identity in 303 aa overlap. Contains possible HTH motif at aa 7-28 (+3.24 SD). Contains a probable helix-turn-helix motif at aa 7-28 (Score 1191, SD +3.24) Q9CBN3 No regulatory proteins PF08242 Q9CBN3 Rv2258c Rv2258c AL450380.2 Mycobrowser_v4 CDS 3024998 3025453 . - 0 ML2538c PPE PPE-family protein (pseudogene) ML2538c, len: 456 bp. Possible pseudogene similar to M. tuberculosis PPE-family proteins e.g. Rv0286, Rv0256c, Rv0096 (Best blastx score: 189). Yes unknown AL450380.2 Mycobrowser_v4 CDS 3229149 3229526 . + 0 ML2679B ML2679B Hypothetical protein ML2679B, len: 125 aa. Hypothetical protein. Q7APS0 No unknown Q7APS0 AL450380.2 Mycobrowser_v4 CDS 3087225 3088583 . + 0 ML2585 ML2585 Probable aldehyde dehydrogenase (pseudogene) ML2585, len: 1359 bp. Possible pseudogene of M. tuberculosis orthologue Rv0223c (1464 bp) (Best blastx scores: 581). Yes intermediary metabolism and respiration Rv0223c Rv0223c AL450380.2 Mycobrowser_v4 CDS 2901013 2901513 . + 0 ML2425 ML2425 conserved hypothetical protein ML2425, len: 166 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0504c SW:Y504_MYCTU (Q11168) (166 aa) fasta scores: E(): 0, 83.1% identity in 166 aa. Also similar to ML1908 and ML1910 from M. leprae. P54879 No conserved hypotheticals P54879 Rv0504c Rv0504c AL450380.2 Mycobrowser_v4 CDS 3239192 3239608 . - 0 ML2689c ML2689c conserved hypothetical protein ML2689c, len: 138 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 15.0 kda protein Rv0049 SW:Y049_MYCTU (P71706) fasta scores: E(): 0, 83.2% in 137 aa. Q7APR8 No conserved hypotheticals Q7APR8 Rv0049 Rv0049 AL450380.2 Mycobrowser_v4 CDS 2131298 2131621 . + 0 ML1756 mmr INVOLVED IN TRANSPORT OF MULTIDRUGS (TETRAPHENYLPHOSPHONIUM, ERYTHROMYCIN, ETHIDIUM BROMIDE, ACRIFLAVINE, SAFRANIN O, PYRONIN Y, etc) ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE BY AN EXPORT MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. MULTIDRUGS-TRANSPORT INTEGRAL MEMBRANE PROTEIN MMR ML1756, len: 107 aa. Probable mmr, integral membrane multidrugs resistance transporter. Highly similar to several multidrug resistance proteins e.g. Escherichia coli quaternary ammonium compound-resistance protein SW: QACE_ECOLI and Mycobacterium tuberculosis Rv3065 SW:YU65_MYCTU (P95094) (107 aa), Fasta scores: E(): 1e-31, 79.0% identity in 105 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00893 DUF7, Integral membrane protein. Q9CBP1 No cell wall and cell processes PF00893 Q9CBP1 GO:0005886,GO:0046677,GO:0006810,GO:0016021 Rv3065 Rv3065 AL450380.2 Mycobrowser_v4 CDS 2917380 2917934 . - 0 ML2442c ML2442c conserved hypothetical protein ML2442c, len: 184 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0487 SW:Y487_MYCTU (Q11153) (183 aa) fasta scores: E(): 0, 69.2% identity in 172 aa. P54139 No conserved hypotheticals PF10770 P54139 Rv0487 Rv0487 AL450380.2 Mycobrowser_v4 CDS 2927244 2927615 . - 0 ML2452c ML2452c hypothetical protein ML2452c, len: 123 aa. Conserved hypothetical protein. Similar in part to Mycobacterium tuberculosis hypothetical protein Rv0477 SW:Y477_MYCTU (Q11144) fasta scores: E(): 1.8e-23, 57.3% identity in 110 aa. Q9CB44 No conserved hypotheticals, cell wall and cell processes PF10783 Q9CB44 Rv0477 Rv0477 AL450380.2 Mycobrowser_v4 CDS 3025572 3026076 . - 0 ML2539c ML2539c Conserved hypothetical protein (pseudogene) ML2539c, len: 505 bp. Possible pseudogene of M. tuberculosis orthologue Rv0281 (909 bp) (Best blastx scores: 180). Yes lipid metabolism Rv0281 Rv0281 AL450380.2 Mycobrowser_v4 CDS 2431991 2432926 . - 0 ML2041c oxyR Probable hydrogen peroxide-inducible genes activator OxyR ML2041c, len: 311 aa. Probable hydrogen peroxide-inducible genes activator. Highly similar to several mycobacterial hydrogen peroxide-inducible genes activators e.g. P52677|OXYR_MYCAV from M. avium (311 aa), fasta scores: E(): 1.5e-96, (78.710% identity in 310 aa overlap); and to OXYR_ECOLI|P11721|P22471 from Escherichia coli (305 aa), fasta scores: E(): 8.1e-33, 37.5% in 288 aa. Identical to previously sequenced OXYR_MYCLE|P52678 from M. leprae probable (311 aa), fasta scores: E(): 0, (100.0% in 311 aa). Also similar to ML2663 from M. leprae. Contains a probable helix-turn-helix motif at aa 23-44 (Score 1404, SD +3.97). Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family. Contains PS00044 Bacterial regulatory proteins. Contains 1 HTH lysR-type DNA-binding domain. P52678 No regulatory proteins PF00126,PF03466 P52678 GO:0006350,GO:0003700,GO:0006355 AL450380.2 Mycobrowser_v4 CDS 1969135 1969995 . + 0 ML1635 panB Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB ML1635, len: 286 aa. Probable panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11). Highly similar to 3-methyl-2-oxobutanoate hydroxymethyltransferases from Escherichia coli SW:PANB_ECOLI (P31057) (264 aa), Fasta scores: E(): 0, 45.9% identity in 257 aa overlap and Mycobacterium tuberculosis Rv2225 SW:PANB_MYCTU (Q10505) (281 aa), Fasta scores: E(): 0, 82.6% identity in 287 aa overlap. Also similar to ML1718 a possible pseudogene similar to M. tuberculosis panB. Q9CBT0 No intermediary metabolism and respiration PF02548 Q9CBT0 GO:0005737,GO:0000287,GO:0015940,GO:0003864 2.1.2.11 Rv2225 Rv2225 AL450380.2 Mycobrowser_v4 CDS 2952003 2952245 . + 0 ML2477 ML2477 PE-family protein (pseudogene) ML2477, len: 243 bp. Possible pseudogene similar to several M. tuberculosis PE-family protein e.g. PE34|Rv3746c and PE35|Rv3872. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2957010 2957706 . - 0 ML2481c ML2481c Possible oxidoreductase (pseudogene) ML2481c, len: 697 bp. Possible pseudogene of M. tuberculosis orthologue Rv0370c (897 bp) (Best blastx scores: 159). Yes intermediary metabolism and respiration Rv0370c Rv0370c AL450380.2 Mycobrowser_v4 CDS 2524157 2524858 . + 0 ML2123 prrA TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA ML2123, len: 233 aa. Probable prrA, two-component response regulator. Similar to Mycobacterium tuberculosis probable transcriptional activator protein cy31.31c Rv0903c TR:Q10531 (EMBL:Z73101) fasta scores: E(): 0, 95.7% in 233 aa, and to Pseudomonas syringae transcriptional activator protein copr SW:COPR_PSESM (Q02540) fasta scores: E(): 2.5e-32, 43.6% in 225 aa. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain. Q50136 No regulatory proteins PF00072,PF00486 Q50136 GO:0005737,GO:0006355,GO:0006350,GO:0000156,GO:0000160,GO:0003677 Rv0903c Rv0903c AL450380.2 Mycobrowser_v4 CDS 3102336 3102890 . + 0 ML2597 ML2597 PROBABLE CONSERVED MCE ASSOCIATED PROTEIN ML2597, len: 184 aa. Probable conserved Mce associated membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0177 TR:O07421 (EMBL:Z97050) fasta scores: E(): 0, 60.9% identity in 184 aa. Contains a possible membrane spanning hydrophobic domain. Q9CD06 No cell wall and cell processes, conserved hypotheticals Q9CD06 Rv0177 Rv0177 AL450380.2 Mycobrowser_v4 CDS 2348340 2349341 . + 0 ML1964 rmlB dTDP-GLUCOSE 4,6-DEHYDRATASE RMLB ML1964, len: 333 aa. Probable rmlB, dTDP-glucose 4,6-dehydratase (EC ). Similar to M. tuberculosis dTDP-glucose 4,6-dehydratase rmlB Rv3464 TR:O06329 (EMBL:Z95390) (331 aa), Fasta scores: E(): 0, 84.0% identity in 331 aa overlap, and to others e.g. Streptococcus pneumoniae DTDP-glucose-4,6-dehydratase cpsN TR:O54611 (EMBL:AF030364) (349 aa), Fasta scores: E(): 0, 59.9% identity in 334 aa overlap. Also similar to ML0204, ML0751, ML1942 and ML2428 from M. leprae. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Q9CBH7 No intermediary metabolism and respiration PF01370 Q9CBH7 GO:0008460,GO:0009225,GO:0050662 4.2.1.46 Rv3464 Rv3464 AL450380.2 Mycobrowser_v4 CDS 2472776 2475112 . - 0 ML2082c secA2 POSSIBLE PREPROTEIN TRANSLOCASE ATPase SECA2 ML2082c, len: 778 aa. Possible secA2, preprotein translocase ATPase. Similar to Mycobacterium tuberculosis preprotein translocase secA 2 subunit Rv1821 SW:SEA2_MYCTU (Q50612) fasta scores: E(): 0, 87.0% in 782 aa, and to Bacillus subtilis preprotein translocase secA subunit SW:SECA_BACSU (P28366) fasta scores: E(): 0, 39.9% in 671 aa. Also similar to ML0779 from M. leprae. Contains Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region. Contains PS01312 Protein secA signatures. O32922 No cell wall and cell processes PF01043,PF07516,PF07517 O32922 GO:0005737,GO:0065002,GO:0005886,GO:0005515,GO:0017038,GO:0006605,GO:0005524 Rv1821 Rv1821 AL450380.2 Mycobrowser_v4 CDS 1912189 1912677 . - 0 ML1586c mpt53 Secreted protein Mpt53 (pseudogene) ML1586c, len: 488 bp. Possible pseudogene of M. tuberculosis orthologue mpt53|Rv2878c (522 bp) (Best blastx scores: 213). Yes cell wall and cell processes Rv2878c Rv2878c AL450380.2 Mycobrowser_v4 CDS 3026816 3027671 . - 0 ML2540c ML2540c Conserved hypothetical protein (pseudogene) ML2540c, len: 856 bp. Possible pseudogene of M. tuberculosis orthologue Rv0276 (921 bp) (Best blastx scores: 333). Yes conserved hypotheticals Rv0276 Rv0276 AL450380.2 Mycobrowser_v4 CDS 3090774 3091577 . + 0 ML2587 yrbE1A CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE1A ML2587, len: 267 aa. Probable yrbE1A, conserved hypothetical integral membrane protein. Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. Rv0167 TR:O07412 (EMBL:Z97050) fasta scores: E(): 0, 88.5% identity in 262 aa. Orthologue of M. tuberculosis YrbE1A (Rv0167). Contains possible membrane spanning hydrophobic domains. Q9CD16 No virulence, detoxification, adaptation PF02405 Q9CD16 Rv0167 Rv0167 AL450380.2 Mycobrowser_v4 CDS 3027842 3028280 . + 0 ML2541 ML2541 Possible transcriptional regulatory protein (pseudogene) ML2541, len: 439 bp. Possible pseudogene of M. tuberculosis orthologue Rv0275c (Best blastx scores: 133). Yes regulatory proteins Rv0275c Rv0275c AL450380.2 Mycobrowser_v4 CDS 2976892 2977297 . + 0 ML2499 ML2499 Probable carbon monoxide dehydrogenase (pseudogene) ML2499, len: 406 bp. Possible pseudogene of M. tuberculosis orthologue Rv0374c (480 bp) (Best blastx scores: 170). Yes intermediary metabolism and respiration Rv0374c Rv0374c AL450380.2 Mycobrowser_v4 CDS 2978855 2979811 . + 0 ML2500 ML2500 Conserved hypothetical protein (pseudogene) ML2500, len: 957 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical proteins e.g. Rv2264c and Rv0312 (Best blastx scores: 77). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2900007 2900909 . + 0 ML2424 serB1 POSSIBLE PHOSPHOSERINE PHOSPHATASE SERB1 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE) ML2424, len: 300 aa. Possible serB1, phosphoserine phosphatase (EC 3.1.3.3). Similar to several including: Mycobacterium tuberculosis phosphoserine phosphatase SerB1 Rv0505c SW:Y505_MYCTU (Q11169) (373 aa) fasta scores: E(): 0, 83.0% identity in 306 aa. Q49823 No intermediary metabolism and respiration PF00702 Q49823 GO:0016791,GO:0008152 Rv0505c Rv0505c AL450380.2 Mycobrowser_v4 CDS 2896541 2897497 . - 0 ML2421c hemC INVOLVED IN PORPHYRIN BIOSYNTHESIS BY THE C5 PATHWAY (AT THE FOURTH STEP). TETRAPOLYMERIZATION OF THE MONOPYRROLE PBG INTO THE HYDROXYMETHYLBILANE PREUROPORPHYRINOGEN IN SEVERAL DISCRETE STEPS [CATALYTIC ACTIVITY: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3]. PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE) ML2421c, len: 318 aa. Probable hemC, porphobilinogen deaminase (EC 4.3.1.8). Similar to Mycobacterium tuberculosis porphobilinogen deaminase Rv0510 SW:HEM3_MYCTU (Q11173) (309 aa) fasta scores: E(): 0, 87.0% identity in 308 aa, and to Escherichia coli porphobilinogen deaminase HemC SW:HEM3_ECOLI (P06983; P78125) (313 aa) fasta scores: E(): 8.4e-30, 42.9% identity in 312 aa. Contains Pfam match to entry PF01379 Porphobil_deam, Porphobilinogen deaminase. Q49808 No intermediary metabolism and respiration PF01379,PF03900 Q49808 GO:0006779,GO:0004418 2.5.1.61 Rv0510 Rv0510 AL450380.2 Mycobrowser_v4 CDS 2952765 2953154 . - 0 ML2478c ML2478c hypothetical protein ML2478c, len: 129 aa. Hypothetical unknown protein (doubtful CDS). Weakly similar in part to Q93H20 Probable metallopeptidase from Streptomyces avermitilis (483 aa), fasta scores: E(): 0.0048, (33.010% identity in 103 aa overlap). Q9CB30 No unknown Q9CB30 AL450380.2 Mycobrowser_v4 CDS 2908016 2909083 . - 0 ML2433c ML2433c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2433c, len: 355 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 33.1 kda protein Rv0497 SW:Y497_MYCTU (Q11162) (310 aa) fasta scores: E(): 4.6e-21, 54.2% identity in 356 aa. Contains multiple possible membrane spanning hydrophobic domains. P54580 No cell wall and cell processes P54580 GO:0005886,GO:0016021 Rv0497 Rv0497 AL450380.2 Mycobrowser_v4 CDS 2930926 2931255 . + 0 ML2458 ML2458 Hypothetical protein (pseudogene) ML2458, len: 330 bp. Possible pseudogene of M. tuberculosis orthologue Rv0471c (489 bp) (Best blastx scores: 123). Yes conserved hypotheticals Rv0471c Rv0471c AL450380.2 Mycobrowser_v4 CDS 2931522 2931902 . + 0 ML2458A ML2458A Conserved hypothetical protein ML2458A, len: 381 bp. Possible psuedogene similar to M. tuberculosis Rv0470A (Best blastx score: 135). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2935189 2936445 . - 0 ML2462c icl Isocitrate lyase Icl (pseudogene) ML2462c, len: 1257 bp. Possible pseudogene of M. tuberculosis orthologue icl|Rv0467 (1287 bp) (Best blastx scores: 511) Yes intermediary metabolism and respiration Rv0467 Rv0467 AL450380.2 Mycobrowser_v4 CDS 2933084 2933941 . - 0 ML2460c umaA Possible mycolic acid synthase UmaA (pseudogene) ML2460c, len: 858 bp. Possible pseudogene of M. tuberculosis orthologue umaA|Rv0469 (861 bp) (Best blastx scores: 697). Yes lipid metabolism Rv0469 Rv0469 AL450380.2 Mycobrowser_v4 CDS 2985842 2985967 . - 0 ML2505c ML2505c Conserved hypothetical protein (pseudogene) ML2505c, len: 126 bp. Possible pseudogene of M. tuberculosis orthologue Rv0332 (786 bp) (Best blastx scores: 98). Yes conserved hypotheticals Rv0332 Rv0332 AL450380.2 Mycobrowser_v4 CDS 2945780 2946453 . + 0 ML2470 proZ Possible osmoprotectant transport integral membrane protein ABC transporter ProZ (pseudogene) ML2470, len: 674 bp. Possible pseudogene of M. tuberculosis orthologue proZ|Rv3756c (720 bp) (Best blastx scores: 114). Yes virulence, detoxification, adaptation Rv3756c Rv3756c AL450380.2 Mycobrowser_v4 CDS 2950647 2950937 . - 0 ML2476c ML2476c Conserved hypothetical protein (pseudogene) ML2476c, len: 96 bp. Possible pseudogene similar to several hypothetical proteins e.g.Q9X8J2|YY12_STRCO Streptomyces coelicolor hypothetical protein (106 aa) (best blastx score: 185) Q9CB31 Yes unknown PF01906 Q9CB31 AL450380.2 Mycobrowser_v4 CDS 2928125 2928691 . - 0 ML2454c hbhA REQUIRED FOR EXTRAPULMONARY DISSEMINATION. MEDIATES ADHERENCE TO EPITHELIAL CELLS BY BINDING TO SULFATED GLYCOCONJUGATES PRESENT AT THE SURFACE OF THESE CELLS; BINDS HEPARIN, DEXTRAN SULFATE, FUCOIDAN AND CHONDROITIN SULFATE. PROMOTES HEMAGGLUTINATION OF ERYTHROCYTES OF CERTAIN HOST SPECIES. INDUCES MYCOBACTERIAL AGGREGATION. IRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN) ML2454c, len: 188 aa. Probable hbhA, iron-regulated herapin binding hemagglutinin. Similar to Mycobacterium tuberculosis heparin-binding hemagglutinin Rv0475 TR:O85733 (EMBL:AF074390) fasta scores: E(): 0, 81.4% identity in 199 aa. Contains a possible N-terminal signal sequence. Q9CB42 No cell wall and cell processes Q9CB42 Rv0475 Rv0475 AL450380.2 Mycobrowser_v4 CDS 2985207 2985584 . - 0 ML2504c ML2504c Hypothetical protein (pseudogene) ML2504c, len: 378 bp. Possible pseudogene of M. tuberculosis orthologue Rv0333 (375 bp) (Best blastx scores: 146). Yes conserved hypotheticals Rv0333 Rv0333 AL450380.2 Mycobrowser_v4 CDS 3028987 3029481 . - 0 ML2542c ML2542c Conserved hypothetical protein (pseudogene) ML2542c, len: 495 bp. Possible pseudogene of M. tuberculosis orthologue Rv0274 (582 bp) (Best blastx scores: 124). Yes conserved hypotheticals Rv0274 Rv0274 AL450380.2 Mycobrowser_v4 CDS 3029666 3030218 . + 0 ML2543 ML2543 putative transcriptional regulator (pseudogene) ML2543, len: 553 bp. Possible pseudogene of M. tuberculosis orthologue Rv0273c (621 bp) (Best blastx scores: 132). Yes regulatory proteins Rv0273c Rv0273c AL450380.2 Mycobrowser_v4 CDS 3031516 3032316 . + 0 ML2545 fadE6 Probable acyl-CoA dehydrogenase FadE6 (pseudogene) ML2545, len: 801 bp. Possible pseudogene of M. tuberculosis orthologue fadE6|Rv0271c (2196 bp) (Best blastx scores: 187). Yes lipid metabolism Rv0271c Rv0271c AL450380.2 Mycobrowser_v4 CDS 2970888 2971577 . - 0 ML2495c grpE PROBABLE GRPE PROTEIN (HSP-70 COFACTOR) ML2495c, len: 229 aa. Probable grpE protein (Hsp70 cofactor). Similar to Mycobacterium tuberculosis GrpE protein Rv0351 SW:GRPE_MYCTU (P32724; O08379) fasta scores: E(): 0, 68.6% identity in 229 aa, and to Streptomyces coelicolor GrpE protein SW:GRPE_STRCO (Q05562) fasta scores: E(): 3.5e-18, 36.8% identity in 212 aa. Contains Pfam match to entry PF01025 GrpE, GrpE. Contains PS01071 grpE protein signature. Q9CB23 No virulence, detoxification, adaptation PF01025 Q9CB23 GO:0051087,GO:0005737,GO:0006457,GO:0042803,GO:0006950,GO:0000774 Rv0351 Rv0351 AL450380.2 Mycobrowser_v4 CDS 2991593 2992012 . + 0 ML2510 ML2510 Probable enoyl-CoA hydratase (pseudogene) ML2510, len: 420 bp. Possible pseudogene similar to several M. tuberculosis probable enoyl-CoA hydratases e.g. echA5|Rv0675, echA8|Rv1070c, echA1|Rv0222 and echA17|Rv3039c (Best blastx scores: 100). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2992637 2993268 . + 0 ML2511 ML2511 Probable sugar-transport integral membrane protein (pseudogene) ML2511, len: 632 bp. Possible pseudogene similar to M. tuberculosis sugI|Rv3331 (1509 bp) (Best blastx scores: 95). Also similar to ML0690c a possible pseudogene similar to M. tuberculosis sugI. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2993287 2993614 . + 0 ML2512 ML2512 conserved hypothetical protein (pseudogene) ML2512, len: 328 bp. Possible pseudogene similar to several M. tuberculosis conserved hypothetical ORFs in REP13E12 repeats e.g. Rv3466, rv1588c, Rv2522, (Best blastx scores: 61) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2993620 2994259 . - 0 ML2513c ML2513c Secreted immunogenic protein Mpb64/Mpt64 (pseudogene) ML2513c, len: 640 bp. Possible pseudogene similar to M. tuberculosis mpt64|Rv1980c (687 bp) (Best blastx scores: 136). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2995551 2996849 . + 0 ML2515 ML2515 Probable conserved transmembrane protein (pseudogene) ML2515, len: 1299 bp. Possible pseudogene similar to M. tuberculosis Rv1635c (1671 bp) (Best blastx scores: 264). Also similar to ML1389c a possible orthologue of M. tuberculosis Rv1635c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2997204 2998923 . - 0 ML2516c ML2516c Possible beta-1,3-glucanase precursor (pseudogene) ML2516c, len: 1720 bp. Possible pseudogene of M. tuberculosis orthologue Rv0315 (885 bp) (Best blastx scores: 440). Also similar to ML1973 a possible pseudogene similar to M. tuberculosis Rv0315. Yes intermediary metabolism and respiration Rv0315 Rv0315 AL450380.2 Mycobrowser_v4 CDS 2999110 2999811 . + 0 ML2517 ML2517 Possible conserved membrane protein (pseudogene) ML2517, len: 702 bp. Possible pseudogene of M. tuberculosis orthologue Rv0314c (663 bp) (Best blastx scores: 174). Yes cell wall and cell processes Rv0314c Rv0314c AL450380.2 Mycobrowser_v4 CDS 3001812 3002629 . - 0 ML2519c ML2519c Conserved hypothetical proline and threonine rich protein (pseudogene) ML2519c, len: 818 bp. Possible pseudogene of M. tuberculosis orthologue Rv0312 (1863 bp) (Best blastx scores: 183). Yes conserved hypotheticals Rv0312 Rv0312 AL450380.2 Mycobrowser_v4 CDS 3004087 3004470 . + 0 ML2521 ML2521 Conserved hypothetical protein (pseudogene) ML2521, len: 384 bp. Possible pseudogene of M. tuberculosis orthologue Rv0310c (492 bp) (Best blastx scores: 193). Yes conserved hypotheticals Rv0310c Rv0310c AL450380.2 Mycobrowser_v4 CDS 3005487 3005904 . - 0 ML2523c ML2523c Probable conserved integral membrane protein (pseudogene) ML2523c, len: 418 bp. Possible pseudogene of M. tuberculosis orthologue Rv0308 (717 bp) (Best blastx scores: 131). Yes cell wall and cell processes Rv0308 Rv0308 AL450380.2 Mycobrowser_v4 CDS 3006114 3006421 . + 0 ML2524 ML2524 Hypothetical protein (pseudogene) ML2524, len: 308 bp. Possible pseudogene of M. tuberculosis orthologue Rv0307c (483 bp) (Best blastx scores: 101). Yes conserved hypotheticals Rv0307c Rv0307c AL450380.2 Mycobrowser_v4 CDS 3009073 3009159 . + 0 ML2526 ML2526 Conserved hypothetical protein (pseudogene) ML2526, len: 87 bp. Possible pseudogene of M. tuberculosis orthologue Rv0295c (804 bp) (Best blastx scores: 100). Yes conserved hypotheticals Rv0295c Rv0295c AL450380.2 Mycobrowser_v4 CDS 3007979 3008968 . + 0 ML2525 ML2525 Proable sulfatase (pseudogene) ML2525, len: 990 bp. Possible pseudogene of M. tuberculosis orthologue Rv0296c (1398 b) (Best blastx scores: 199). Yes intermediary metabolism and respiration Rv0296c Rv0296c AL450380.2 Mycobrowser_v4 CDS 3014526 3014822 . - 0 ML2532c esxG ESAT-6 LIKE PROTEIN ESXG (CONSERVED HYPOTHETICAL PROTEIN TB9.8) ML2532c, len: 98 aa. Probable esxG, esat-6 like protein. Similar to Mycobacterium tuberculosis Rv0287 esxG, esat-6 like protein (97 aa), fasta scores: E(): 4.2e-24, (76.842% identity in 95 aa overlap). Q9CD32 No cell wall and cell processes Q9CD32 Rv0287 Rv0287 AL450380.2 Mycobrowser_v4 CDS 3014197 3014487 . - 0 ML2531c esxH LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7 ESXH (10 kDa ANTIGEN) (CFP-7) (PROTEIN TB10.4) ML2531c, len: 96 aa. Probable esxH, low molecular weight protein antigen 7. Similar to Mycobacterium tuberculosis low molecular weight protein antigen 7 Rv0288 SW:CFP7_MYCTU (O53693) fasta scores: E(): 6.1e-29, 70.5% identity in 95 aa. Q9CD33 No cell wall and cell processes Q9CD33 Rv0288 Rv0288 AL450380.2 Mycobrowser_v4 CDS 3040719 3044922 . + 0 ML2552 narK3 Probable nitrite extrusion protein NarK3 (pseudogene) ML2552, len: 4204 bp. Possible pseudogene of M. tuberculosis orthologue narK3|Rv0261c (Best blastx scores: 288). This pseudo gene appears to bound a perfectly duplicated portion of sequence. Yes cell wall and cell processes Rv0261c Rv0261c AL450380.2 Mycobrowser_v4 CDS 3045299 3045711 . + 0 ML2553 ML2553 Conserved hypothetical protein (pseudogene) ML2553, len: 413 bp. Possible pseudogene of M. tuberculosis orthologue Rv0258c (456 bp) (Best blastx scores: 273). Yes conserved hypotheticals Rv0258c Rv0258c AL450380.2 Mycobrowser_v4 CDS 3045799 3046081 . - 0 ML2554c nirD Probable nitrite reductase small subunit NirD (pseudogene) ML2554c, len: 283 bp. Possible pseudogene of M. tuberculosis orthologue nirD|Rv0253 (357 bp) (Best blastx scores: 203). Yes intermediary metabolism and respiration Rv0253 Rv0253 AL450380.2 Mycobrowser_v4 CDS 3046140 3048595 . - 0 ML2555c nirB Probable nitrite reductase flavoprotein NirB (pseudogene) ML2555c, len: 2456 bp. Possible pseudogene of M. tuberculosis orthologue nirB|Rv0252 (2562 bp) (Best blastx scores: 292). Yes intermediary metabolism and respiration Rv0252 Rv0252 AL450380.2 Mycobrowser_v4 CDS 3048665 3048970 . + 0 ML2556 hsp Heat-stress-induced ribosome-binding protein A Hsp (pseudogene) ML2556, len: 306 bp. Possible pseudogene of M. tuberculosis orthologue hsp|Rv0251c (480 bp) (Best blastx scores: 188). Yes virulence, detoxification, adaptation Rv0251c Rv0251c AL450380.2 Mycobrowser_v4 CDS 3049674 3050482 . + 0 ML2558 ML2558 Probable succinate dehydrogenase (pseudogene) ML2558, len: 809 bp. Possible pseudogene of M. tuberculosis orthologue Rv0249c (822 bp) (Best blastx scores: 298). Yes intermediary metabolism and respiration Rv0249c Rv0249c AL450380.2 Mycobrowser_v4 CDS 3050532 3052355 . + 0 ML2559 ML2559 Probable succinate dehydrogenase (pseudogene) ML2559, len: 1824 bp. Possible pseudogene of M. tuberculosis orthologue Rv0248c (1941 bp) (Best blastx scores: 750). Yes intermediary metabolism and respiration Rv0248c Rv0248c AL450380.2 Mycobrowser_v4 CDS 3052451 3053095 . + 0 ML2560 ML2560 Probable succinate dehydrogenase (pseudogene) ML2560, len: 645 bp. Possible pseudogene of M. tuberculosis orthologue Rv0247c (747 bp) (Best blastx scores: 463). Yes intermediary metabolism and respiration Rv0247c Rv0247c AL450380.2 Mycobrowser_v4 CDS 3167447 3168460 . - 0 ML2648c cyp138 Probable cytochrome p450 138 Cyp138 (pseudogene) ML2648c, len: 1014 bp. Possible pseudogene of M. tuberculosis orthologue Rv0136|cyp138 (1326 bp) (Best blastx scores: 166). Yes intermediary metabolism and respiration Rv0136 Rv0136 AL450380.2 Mycobrowser_v4 CDS 3049302 3049598 . + 0 ML2557 ML2557 conserved hypothetical protein ML2557, len: 98 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0250c TR:O53672 (EMBL:AL021929) fasta scores: E(): 2e-26, 72.6% identity in 95 aa. Q7APU6 No conserved hypotheticals Q7APU6 Rv0250c Rv0250c AL450380.2 Mycobrowser_v4 CDS 3070538 3071556 . + 0 ML2572 ML2572 Probable conserved transmembrane protein (pseudogene) ML2572, len: 1019 bp. Possible pseudogene of M. tuberculosis orthologue Rv0235c (1449 bp) (Best blastx scores: 292). Yes cell wall and cell processes Rv0235c Rv0235c AL450380.2 Mycobrowser_v4 CDS 3075139 3076034 . - 0 ML2574c nrdB Probable ribonucleoside-diphosphate reductase (beta chain) NrdB (pseudogene) ML2574c, len: 896 bp. Possible pseudogene of M. tuberculosis orthologue nrdB|Rv0233 (945 bp) (Best blastx scores: 384). Yes information pathways Rv0233 Rv0233 AL450380.2 Mycobrowser_v4 CDS 3076082 3076404 . - 0 ML2575c ML2575c Probable transcriptional regulatory protein (TetR/AcrR family) (pseudogene) ML2575c, len: 323 bp. Possible pseudogene of M. tuberculosis orthologue Rv0232 (690 bp) (Best blastx scores: 154). Yes regulatory proteins Rv0232 Rv0232 AL450380.2 Mycobrowser_v4 CDS 3076541 3076847 . - 0 ML2576c ML2576c Conserved hypothetical protein (pseudogene) ML2576c, len: 307 bp. Possible pseudogene of M. tuberculosis orthologue Rv1102c (312 bp) (Best blastx scores: 138). Yes virulence, detoxification, adaptation Rv1102c Rv1102c AL450380.2 Mycobrowser_v4 CDS 3077137 3078710 . - 0 ML2578c fadE4 Probable acyl-CoA dehydrogenase FadE4 (pseudogene) ML2578c, len: 1574 bp. Possible pseudogene of M. tuberculosis orthologue fadE4|Rv0231 (1707 bp) (Best blastx scores: 445). Yes lipid metabolism Rv0231 Rv0231 AL450380.2 Mycobrowser_v4 CDS 3078928 3079868 . + 0 ML2579 php Probable phosphotriesterase Php (pseudogene) ML2579, len: 941 bp. Possible pseudogene of M. tuberculosis orthologue Rv0230c|php (981 bp) (Best blastx scores: 317). Yes lipid metabolism Rv0230c Rv0230c AL450380.2 Mycobrowser_v4 CDS 3173929 3174417 . + 0 ML2652 ML2652 Hypothetical protein (pseudogene) ML2652, len: 489 bp. Possible pseudogene of M. tuberculosis orthologue Rv0088 (675 bp) (Best blastx scores: 157). Yes lipid metabolism Rv0088 Rv0088 AL450380.2 Mycobrowser_v4 CDS 3176090 3176572 . + 0 ML2653 ML2653 Possible membrane protein (pseudogene) ML2653, len: 483 bp. Possible pseudogene of M. tuberculosis orthologue Rv0090 (771 bp) (Best blastx scores: 245). Yes cell wall and cell processes Rv0090 Rv0090 AL450380.2 Mycobrowser_v4 CDS 3065276 3065449 . + 0 ML2569A ML2569A SMALL SECRETED PROTEIN ML2569A, len: 57 aa. Possible small secreted protein. Orthologue of Mycobacterium tuberculosis, Rv0236A|P58240|Y23A_MYCTU Putative secreted protein (57 aa), fasta scores: E(): 1.8e-18, (89.474% identity in 57 aa overlap). Q9CD20 No cell wall and cell processes Q9CD20 Rv0236A Rv0236A AL450380.2 Mycobrowser_v4 CDS 3091581 3092450 . + 0 ML2588 yrbE1B CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE1B ML2588, len: 289 aa. Probable yrbE1B, conserved hypothetical integral membrane protein. Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. Rv0168 TR:O07413 (EMBL:Z97050) fasta scores: E(): 0, 85.1% identity in 289 aa. Orthologue of M. tuberculosis YrbE1B (Rv0168). Contains possible membrane spanning hydrophobic domains. Q9CD15 No virulence, detoxification, adaptation PF02405 Q9CD15 Rv0168 Rv0168 AL450380.2 Mycobrowser_v4 CDS 3081546 3082829 . + 0 ML2581 ML2581 PROBABLE CONSERVED MEMBRANE PROTEIN ML2581, len: 427 aa. Probable conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0227c TR:P96409 (EMBL:Z92669) fasta scores: E(): 0, 76.6% identity in 423 aa. Contains a possible N-terminal signal sequence and a possible membrane spanning hydrophobic domain. Q9CD18 No cell wall and cell processes Q9CD18 Rv0227c Rv0227c AL450380.2 Mycobrowser_v4 CDS 3142545 3143917 . - 0 ML2628c ML2628c acyl-CoA synthase (pseudogene) ML2628c, len: 1373 bp. Possible pseudogene similar to M. tuberculosis fadD5 (Best blastx scores: 184), Also similar to ML2586 a possible pseudogene similar to M. tuberculosis fadD5. Yes unknown AL450380.2 Mycobrowser_v4 CDS 3154968 3155414 . + 0 ML2637 fadE2 Probable acyl-CoA dehydrogenase FadE2 (pseudogene) ML2637, len: 447 bp. Possible pseudogene of M. tuberculosis orthologue fadE2|Rv0154c (1212 bp) (Best blastx scores: 177). Yes lipid metabolism Rv0154c Rv0154c AL450380.2 Mycobrowser_v4 CDS 3159064 3159996 . - 0 ML2640c ML2640c conserved hypothetical protein ML2640c, len: 310 aa. Conserved hypothetical protein. Highly similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv0146 TR:P96823 (EMBL:Z92770) fasta scores: E(): 0, 78.1% identity in 310 aa. Q9CCZ4 No conserved hypotheticals, lipid metabolism 2CKD,2UYO,2UYQ PF02409 Q9CCZ4 GO:0008168 2.1.1.- Rv0146 Rv0146 AL450380.2 Mycobrowser_v4 CDS 3173298 3173615 . + 0 ML2651 ML2651 hypothetical protein ML2651, len: 105 aa. Hypothetical unknown protein. Q9CCZ1 No unknown Q9CCZ1 AL450380.2 Mycobrowser_v4 CDS 3161029 3161653 . - 0 ML2642c ML2642c Probable transcriptional regulatory protein (tetR family) (pseudogene) ML2642c, len: 625 bp. Possible pseudogene of M. tuberculosis orthologue Rv0144 (843 bp) (Best blastx scores: 349). Yes regulatory proteins Rv0144 Rv0144 AL450380.2 Mycobrowser_v4 CDS 3166260 3166653 . - 0 ML2646c ML2646c Conserved hypothetical protein (pseudogene) ML2646c, len: 394 bp. Possible pseudogene of M. tuberculosis orthologue Rv0138 (504 bp) (Best blastx scores: 104). Yes conserved hypotheticals Rv0138 Rv0138 AL450380.2 Mycobrowser_v4 CDS 3196732 3197079 . + 0 ML2668 ML2668 Hypothetical protein (pseudogene) ML2668, len: 348 bp. Possible pseudogene similar to M. tuberculosis Rv1805c (348 bp) (Best blastx scores: 86). Also similar to ML1535 a possible pseudogene similar to M. tuberculosis Rv1805c. Yes unknown AL450380.2 Mycobrowser_v4 CDS 260507 260906 . - 0 ML0194c PE_PGRS1 PE-PGRS family-related protein (pseudogene) ML0194c, len: 400 bp. Possible pseudogene of M. tuberculosis orthologue Rv3653|PE_PGRS61 (588 bp) (Best blastx scores: 94). Yes PE/PPE Rv3653 Rv3653 AL450380.2 Mycobrowser_v4 CDS 3267519 3267662 . - 0 ML2713c rpmH 50S RIBOSOMAL PROTEIN L34 RPMH ML2713c, len: 47 aa. rpmH, 50S ribosomal protein L34. Highly similar to many 50s ribosomal proteins (L34) e.g. Mycobacterium avium SW:RL34_MYCAV (Q9ZB91) (46 aa), Fasta scores: E(): 1.4e-15, 83.0% identity in 47 aa overlap and Mycobacterium tuberculosis Rv3924c SW:RL34_MYCTU (P52829) (47 aa), Fasta scores: E(): 2.1e-18, 91.5% identity in 47 aa overlap. Contains Pfam match to entry PF00468 Ribosomal_L34, Ribosomal protein L34. Contains PS00784 Ribosomal protein L34 signature. P46386 No information pathways PF00468 P46386 GO:0003735,GO:0006412,GO:0005840 Rv3924c Rv3924c AL450380.2 Mycobrowser_v4 CDS 2934094 2934957 . - 0 ML2461c fadB2 PROBABLE 3-HYDROXYBUTYRYL-CoA DEHYDROGENASE FADB2 (BETA-HYDROXYBUTYRYL-CoA DEHYDROGENASE) (BHBD) ML2461c, len: 287 aa. Probable fadB2, 3-hydroxyacyl-CoA dehydrogenas (EC 1.1.1.157). Similar to Mycobacterium tuberculosis putative 3-hydroxyacyl-CoA dehydrogenase Rv0468 TR:O53753 (EMBL:AL021933) fasta scores: E(): 0, 89.5% identity in 287 aa, and to Clostridium acetobutylicum 3-hydroxybutyryl-CoA dehydrogenase SW:HBD_CLOAB (P52041) fasta scores: E(): 0, 43.3% identity in 282 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. Q9CB39 No lipid metabolism PF00725,PF02737 Q9CB39 GO:0006631,GO:0055114,GO:0016491,GO:0050662 Rv0468 Rv0468 AL450380.2 Mycobrowser_v4 CDS 3239878 3240694 . + 0 ML2690 ML2690 Possible membrane protein (pseudogene) ML2690, len: 817 bp. Possible pseudogene of M. tuberculosis orthologue Rv0048c (870 bp) (Best blastx scores: 126). Yes cell wall and cell processes Rv0048c Rv0048c AL450380.2 Mycobrowser_v4 CDS 3257506 3258095 . + 0 ML2702 ML2702 Hypothetical alanine rich protein (pseudogene) ML2702, len: 590 bp. Possible pseudogene of M. tuberculosis orthologue Rv3912 (765 bp) (Best blastx scores: 80) Yes conserved hypotheticals Rv3912 Rv3912 AL450380.2 Mycobrowser_v4 CDS 3197436 3197756 . + 0 ML2669 ML2669 hypothetical protein ML2669, len: 106 aa. Hypothetical protein. Weakly similar in part to Q89MG4 Bll4229 protein from Bradyrhizobium japonicum (221 aa), fasta scores: E(): 0.011, (35.135% identity in 74 aa overlap). Q7APS4 No unknown Q7APS4 AL450380.2 Mycobrowser_v4 CDS 3097961 3099139 . + 0 ML2593 lprK POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E) ML2593, len: 392 aa. Possible lprK, Mce-family lipoprotein. Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. Rv0173 TR:O07417 (EMBL:Z97050) fasta scores: E(): 0, 76.3% identity in 389 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Orthologue of M. tuberculosis lprK (mce1E, Rv0173). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CD10 No cell wall and cell processes PF02470 Q9CD10 Rv0173 Rv0173 AL450380.2 Mycobrowser_v4 CDS 3216470 3217086 . + 0 ML2675 glnQ Probable glutamine-transport ATP-binding protein ABC transporte GlnQ (pseudogene) ML2675, len: 617 bp. Possible pseudogene of M. tuberculosis orthologue glnQ|Rv2564 (993 bp) (Best blastx scores: 312) and also similar to Rv0073. Yes cell wall and cell processes Rv2564 Rv2564 AL450380.2 Mycobrowser_v4 CDS 3103594 3104619 . - 0 ML2599c lprO Possible lipoprotein LprO (pseudogene) ML2599c, len: 1026 bp. Possible pseudogene of M. tuberculosis orthologue lprO|Rv0179c (1110 bp) (Best blastx scores: 158). Yes cell wall and cell processes Rv0179c Rv0179c AL450380.2 Mycobrowser_v4 CDS 3106136 3106797 . - 0 ML2601c ML2601c Conserved hypothetical protein (pseudogene) ML2601c, len: 662 bp. Possible pseudogene of M. tuberculosis orthologue Rv0181c (735 bp) (Best blastx scores: 140). Yes conserved hypotheticals Rv0181c Rv0181c AL450380.2 Mycobrowser_v4 CDS 3193715 3193969 . - 0 ML2666c ML2666c hypothetical protein ML2666c, len: 84 aa. Hypothetical unknown protein. Q9CCY7 No unknown Q9CCY7 AL450380.2 Mycobrowser_v4 CDS 3108455 3109204 . + 0 ML2604 ML2604 conserved hypothetical protein ML2604, len: 249 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 26.8 kda protein Rv0184 TR:O07428 (EMBL:Z97050) fasta scores: E(): 0, 81.9% identity in 249 aa. Q9CD02 No conserved hypotheticals Q9CD02 Rv0184 Rv0184 AL450380.2 Mycobrowser_v4 CDS 3010280 3011707 . - 0 ML2528c mycP3 PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) ML2528c, len: 475 aa. Probable mycP3, membrane-anchored mycosin (EC 3.4.21.-). Similar to many proposed proteases e.g. Mycobacterium tuberculosis putative protease Rv0291 TR:O53695 (EMBL:AL021930) fasta scores: E(): 0, 69.9% id in 468 aa. Also similar to ML0041 and ML1538 from M. leprae. Contains 2 Pfam matches to entry PF00082 Peptidase_S8, Subtilase family. Contains PS00137 Serine proteases. Q9CD36 No intermediary metabolism and respiration PF00082 Q9CD36 GO:0004252,GO:0006508 Rv0291 Rv0291 AL450380.2 Mycobrowser_v4 CDS 2914497 2915093 . - 0 ML2439c regX3 TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) ML2439c, len: 198 aa. regX3, response regulator protein (sensory transduction protein). Similar to Synechococcus sp alkaline phosphatase synthesis transcriptional regulatory protein SphR SW:SPHR_SYNP7 (P39663) (257 aa) fasta scores: E(): 6.6e-33, 47.1% identity in 206 aa, and to Mycobacterium tuberculosis sensory transduction protein RegX3 Rv0491 SW:RGX3_MYCTU (Q11156) (227 aa) fasta scores: E(): 0, 95.9% identity in 197 aa. Also similar to ML0773, ML0174 and ML2123 from M. leprae. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain. P54884 No regulatory proteins PF00072,PF00486 P54884 GO:0005622,GO:0006355,GO:0006350,GO:0000156,GO:0000160,GO:0003677 Rv0491 Rv0491 AL450380.2 Mycobrowser_v4 CDS 3137850 3138098 . + 0 ML2625 fadD4 Probable fatty-acid-CoA synthase FadD4 (pseudogene) ML2625, len: 249 bp. Possible pseudogene of M. tuberculosis orthologue fadD4|Rv0214 (1614 bp) (Best blastx scores: 231). Yes lipid metabolism Rv0214 Rv0214 AL450380.2 Mycobrowser_v4 CDS 3187869 3189304 . + 0 ML2662 oxcA Probable oxalyl-CoA decarboxylase OxcA (pseudogene) ML2662, len: 1436 bp. Possible pseudogene of M. tuberculosis orthologue oxcA|Rv0118c (1749 bp) (Best blastx scores: 220). Yes intermediary metabolism and respiration Rv0118c Rv0118c AL450380.2 Mycobrowser_v4 CDS 3106891 3107607 . - 0 ML2602c sigG Probable alternative RNA polymerase sigma subunit factor SigG (pseudogene) ML2602c, len: 717 bp. Possible pseudogene of M. tuberculosis orthologue sigG|Rv0182c (1113 bp) (Best blastx scores: 149). Yes information pathways Rv0182c Rv0182c AL450380.2 Mycobrowser_v4 CDS 3139468 3139984 . - 0 ML2626c fadE3 Probable acyl-CoA dehydrogenase FadE3 (pseudogene) ML2626c, len: 517 bp. Possible pseudogene of M. tuberculosis orthologue fadE3|Rv0215c (1074 bp) (Best blastx scores: 159). Also similar to ML1179 a possible pseudogene similar to M. tuberculosis fadE3. Yes lipid metabolism Rv0215c Rv0215c AL450380.2 Mycobrowser_v4 CDS 3160315 3160872 . - 0 ML2641c ML2641c Conserved hypothetical protein (pseudogene) ML2641c, len: 558 bp. Possible pseudogene of M. tuberculosis orthologue Rv0145 (954 bp) (Best blastx scores: 240). Yes lipid metabolism Rv0145 Rv0145 AL450380.2 Mycobrowser_v4 CDS 3163937 3164219 . + 0 ML2644 ML2644 Hypothetical protein (pseudogene) ML2644, len: 283 bp. Possible pseudogene of M. tuberculosis orthologue Rv0141c (411 bp) (Best blastx scores: 119) Yes conserved hypotheticals Rv0141c Rv0141c AL450380.2 Mycobrowser_v4 CDS 3264991 3265572 . - 0 ML2709c ML2709c conserved hypothetical protein ML2709c, len: 193 aa. conserved hypothetical protein similar to several JAG proteins. Similar to Mycobacterium paratuberculosis hypothetical 20.1 kda protein TR:AAF33691 (EMBL:AF222789) fasta scores: E(): 0, 76.0% in 183 aa, and to Mycobacterium tuberculosis hypothetical 20.6 kda protein Rv3920c TR:O53598 (EMBL:AL021426) fasta scores: E(): 0, 73.1% in 193 aa. Contains Pfam match to entry PF01424 R3H, R3H domain. Q7APR5 No conserved hypotheticals PF01424 Q7APR5 GO:0003676 Rv3920c Rv3920c AL450380.2 Mycobrowser_v4 CDS 3109773 3110967 . + 0 ML2606 bglS Probable beta-glucosidase BglS (pseudogene) ML2606, len: 1195 bp. Possible pseudogene of M. tuberculosis orthologue bglS|Rv0186 (2076 bp) (Best blastx scores: 408). Yes intermediary metabolism and respiration Rv0186 Rv0186 AL450380.2 Mycobrowser_v4 CDS 3112058 3112687 . - 0 ML2607c ML2607c polyketide synthase (pseudogene) ML2607c, len: 630 bp. Possible pseudogene similar to Mycobacterium tuberculosis polyketide synthase Rv3800c|pks13|O53579|AL022076. Also similar to ML0101 a possible orthologue of M. tuberculosis pks13. Yes unknown AL450380.2 Mycobrowser_v4 CDS 3115280 3115739 . + 0 ML2610 ML2610 Probable conserved integral membrane protein (pseudogene) ML2610, len: 460 bp. Possible pseudogene of M. tuberculosis orthologue Rv0191 (1242 bp) (Best blastx scores: 133). Yes cell wall and cell processes Rv0191 Rv0191 AL450380.2 Mycobrowser_v4 CDS 3116035 3116789 . + 0 ML2611 ML2611 Conserved hypothetical protein (pseudogene) ML2611, len: 755 bp. Possible pseudogene of M. tuberculosis orthologue Rv0192 (1101 bp) (Best blastx scores: 190). Yes conserved hypotheticals Rv0192 Rv0192 AL450380.2 Mycobrowser_v4 CDS 3117044 3118778 . + 0 ML2612 ML2612 Possible oxidoreductase (pseudogene) ML2612, len: 1735 bp. Possible pseudogene of M. tuberculosis orthologue Rv0197 (2289 bp) (Best blastx scores: 496). Yes intermediary metabolism and respiration Rv0197 Rv0197 AL450380.2 Mycobrowser_v4 CDS 3114791 3115198 . + 0 ML2609 ML2609 conserved hypothetical protein ML2609, len: 135 aa. Conserved hypothetical protein. Similar in parts to several proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv0190 TR:O07434 (EMBL:Z97050) fasta scores: E(): 6.6e-27, 82.6% identity in 92 aa. Q7APT4 No conserved hypotheticals PF02583 Q7APT4 Rv0190 Rv0190 AL450380.2 Mycobrowser_v4 CDS 3120837 3121511 . + 0 ML2614 ML2614 PROBABLE CONSERVED MEMBRANE PROTEIN ML2614, len: 224 aa. Probable conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0199 TR:O53650 (EMBL:AL021928) fasta scores: E(): 0, 67.6% identity in 219 aa. Contains possible membrane spanning hydrophobic domain. Q7APT2 No cell wall and cell processes Q7APT2 Rv0199 Rv0199 AL450380.2 Mycobrowser_v4 CDS 207107 207445 . - 0 ML0145A ML0145A hypothetical protein(pseudogene) ML0145A, len:338. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.004 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3121508 3122197 . + 0 ML2615 ML2615 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN ML2615, len: 229 aa. Possible conserved membrane protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0200 TR:O53651 (EMBL:AL021928) fasta scores: E(): 0, 74.7% identity in 229 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. Q7APT1 No cell wall and cell processes Q7APT1 Rv0200 Rv0200 AL450380.2 Mycobrowser_v4 CDS 3155970 3156514 . - 0 ML2638c ML2638c Possible quinone oxidoreductase (pseudogene) ML2638c, len: 545 bp. Possible pseudogene of M. tuberculosis orthologue Rv0149 (969 bp) (Best blastx scores: 121). Yes intermediary metabolism and respiration Rv0149 Rv0149 AL450380.2 Mycobrowser_v4 CDS 3140270 3141289 . + 0 ML2627 ML2627 conserved hypothetical protein ML2627, len: 339 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 35.8 kda protein Rv0216 OR MTCY08D5.11 TR:P96398 (EMBL:Z92669) fasta scores: E(): 0, 74.0% identity in 338 aa. Q7APS9 No conserved hypotheticals, intermediary metabolism and respiration Q7APS9 Rv0216 Rv0216 AL450380.2 Mycobrowser_v4 CDS 3147704 3149053 . - 0 ML2631c ML2631c possible oxidoreductase ML2631c, len: 449 aa. Possible oxidoreductase. Similar to Mycobacterium tuberculosis hypothetical protein Rv0161 TR:O07406 (EMBL:Z97050) fasta scores: E(): 0, 78.8% identity in 449 aa, and to Escherichia coli glycolate oxidase subunit GlcD SW:GLCD_ECOLI (P52075) fasta scores: E(): 1.1e-29, 28.7% identity in 457 aa. Also similar to ML1103 from M. leprae. Contains Pfam match to entry PF01565 FAD_binding_4, FAD binding domain. Q7APS7 No intermediary metabolism and respiration PF01565,PF02913 Q7APS7 GO:0016491,GO:0050660 Rv0161 Rv0161 AL450380.2 Mycobrowser_v4 CDS 3178893 3179180 . - 0 ML2656c ML2656c Probable conserved transmembrane protein (pseudogene) ML2656c, len: 288 bp. Possible pseudogene of M. tuberculosis orthologue Rv0128 (780 bp) (Best blastx scores: 242). Yes cell wall and cell processes Rv0128 Rv0128 AL450380.2 Mycobrowser_v4 CDS 3179436 3179935 . - 0 ML2657c ML2657c Conserved hypothetical protein (pseudogene) ML2657c, len: 500 bp. Possible pseudogene of M. tuberculosis orthologue Rv0127 (1368 bp) (Best blastx scores: 255). Yes virulence, detoxification, adaptation Rv0127 Rv0127 AL450380.2 Mycobrowser_v4 CDS 3180268 3181913 . - 0 ML2658c treS Trehalose synthase TreS (pseudogene) ML2658c, len: 1646 bp. Possible pseudogene of M. tuberculosis orthologue Rv0126|treS (1806 bp) (Best blastx scores: 589). Yes virulence, detoxification, adaptation Rv0126 Rv0126 AL450380.2 Mycobrowser_v4 CDS 3189384 3190316 . - 0 ML2663c oxyS OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN OXYS ML2663c, len: 310 aa. oxyS, oxidative stress response regulatory protein. Similar to Mycobacterium tuberculosis OxyS|Rv0117 protein TR:O33175 (EMBL:AJ000188) fasta scores: E(): 0, 81.5% in 314 aa, and to Streptomyces coelicolor A3 OxyR a regulator of the hydroperoxide reductase system TR:Q9RN71 (EMBL:AF186371) fasta scores: E(): 5.9e-16, 31.2% in 292 aa. Contains a putative helix-turn-helix motif situated between residues 16..37 (+4.35 SD). Contains a probable helix-turn-helix motif at aa 16-37 (Score 1517, SD +4.35) Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family. Contains PS00044 Bacterial regulatory proteins. Q9ZBE7 No regulatory proteins PF00126,PF03466 Q9ZBE7 GO:0003700,GO:0006355 Rv0117 Rv0117 AL450380.2 Mycobrowser_v4 CDS 3234139 3234429 . - 0 ML2685c rpsF PROBABLE 30S RIBOSOMAL PROTEIN S6 RPSF ML2685c, len: 96 aa. Probable rpsF, 30S ribosomal protein S6. Similar to Bacillus subtilis 30s ribosomal protein S6 SW:RS6_BACSU (P21468) fasta scores: E(): 1.3e-10, 34.7% in 95 aa, and to Mycobacterium tuberculosis 30s ribosomal protein S6 Rv0053 SW:RS6_MYCTU (P71710) fasta scores: E(): 0, 91.7% in 96 aa. Contains Pfam match to entry PF01250 Ribosomal_S6, Ribosomal protein S6. Contains PS01048 Ribosomal protein S6 signature. P46389 No information pathways PF01250 P46389 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0053 Rv0053 AL450380.2 Mycobrowser_v4 CDS 3149645 3150487 . + 0 ML2632 PE11 PE-family protein (pseudogene) ML2632, len: 843 bp. Possible pseudogene of M. tuberculosis orthologue PE4|Rv0160c (1509 bp) and highly similar to PE3|Rv0159c (Best blastx scores: 165). Yes PE/PPE Rv0160c Rv0160c AL450380.2 Mycobrowser_v4 CDS 3246228 3246683 . + 0 ML2695 ML2695 Probable ATP-binding protein ABC transporter (pseudogene) ML2695, len: 456 bp. Possible pseudogene similar to several M. tuberculosis ATP-binding transport proteins e.g. proV|Rv3758c and pstB|Rv0933 (Best blastx scores: 96). Yes unknown AL450380.2 Mycobrowser_v4 CDS 2572733 2573764 . + 0 ML2163 dapC Probable aminotransferase (pseudogene) ML2163, len: 1032 bp. Possible pseudogene of M. tuberculosis orthologue Rv0858c (1194 bp) (Best blastx scores: 361). Yes intermediary metabolism and respiration Rv0858c Rv0858c AL450380.2 Mycobrowser_v4 CDS 1696463 1696780 . + 0 ML1414 PE_PGRS5 PGRS-family protein (pseudogene) ML1414, len: 318 bp. Possible pseudogene similar to several M. tuberculosis PGRS-family proteins e.g. PE_PGRS15, PE_PGRS33, PE_PGRS23, PE_PGRS46 etc. Yes unknown AL450380.2 Mycobrowser_v4 CDS 2659809 2660844 . - 0 ML2241c PE_PGRS6 PE_PGRS-family protein (pseudogene) ML2241c, len: 1036 bp. Possible pseudogene of M. tuberculosis orthologue PE_PGRS11|Rv0754 (1755 bp) (Best blastx scores: 185). Yes PE/PPE Rv0754 Rv0754 AL450380.2 Mycobrowser_v4 CDS 3240807 3241349 . + 0 ML2691 ML2691 conserved hypothetical protein ML2691, len: 180 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 20.4 kda protein Rv0047c cy21d4.10c precursor TR:P71704 (EMBL:Z80775) fasta scores: E(): 0, 89.4% in 180 aa, and to Streptomyces coelicolor hypothetical 25.2 kda protein TR:Q9X8T6 (EMBL:AL049826) fasta scores: E(): 4.2e-32, 51.9% in 181 aa. Contains a possible coiled-coil region between residues 120..140. Q9CCY3 No conserved hypotheticals PF03551 Q9CCY3 Rv0047c Rv0047c AL450380.2 Mycobrowser_v4 CDS 2380922 2381473 . + 0 ML1993 fcoT conserved hypothetical protein ML1993, len: 183 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetiacl protein Rv0098 SW:Y098_MYCTU (Q10894) (183 aa), Fasta scores: E(): 0, 65.6% identity in 180 aa overlap. Q9CBG3 No conserved hypotheticals, lipid metabolism Q9CBG3 Rv0098 Rv0098 AL450380.2 Mycobrowser_v4 CDS 3263121 3264176 . - 0 ML2707c parA PROBABLE CHROMOSOME PARTITIONING PROTEIN PARA ML2707c, len: 351 aa. Probable parA, chromosome partitioning protein. Similar to many proteins thought to be involved with chromosome partitioning e.g. Mycobacterium tuberculosis hypothetical 37.5 kda protein Rv3918c TR:O53596 (EMBL:AL021426) fasta scores: E(): 0, 78.1% in 347 aa, and to Bacillus subtilis soj protein SW:SOJ_BACSU (P37522) fasta scores: E(): 0, 52.6% in 251 aa. Contains Pfam match to entry PF00991 ParA, ParA family ATPase. Q9CCX7 No cell wall and cell processes PF01656 Q9CCX7 GO:0009236,GO:0042242,GO:0051301 Rv3918c Rv3918c AL450380.2 Mycobrowser_v4 CDS 262754 262939 . - 0 ML0196c PE1 PE family protein (pseudogene) ML0196c, len: 186 bp. Possible pseudogene of M. tuberculosis orthologue Rv3650|PE33 (285 bp) (Best blastx scores: 94) Yes PE/PPE Rv3650 Rv3650 AL450380.2 Mycobrowser_v4 CDS 343372 343984 . - 0 ML0263c PE2 PE-family protein (pseudogene) ML0263c, len: 613 bp. Possible pseudogene of M. tuberculosis orthologue Rv1040c|PE8 (828 bp) (Best blastx scores: 122) Yes PE/PPE Rv1040c Rv1040c AL450380.2 Mycobrowser_v4 CDS 3016111 3016419 . - 0 ML2534c PE10 PE-family protein ML2534c, len: 102 aa. Member of the PE protein family. Similar to Mycobacterium tuberculosis PE-family protein Rv0285 PE5 MTV035.13 TR:O53690 (EMBL:AL021930) fasta scores: E(): 2.1e-23, 73.0% identity in 100 aa. Q9CD31 No PE/PPE PF00934 Q9CD31 Rv0285 Rv0285 AL450380.2 Mycobrowser_v4 CDS 1581170 1582165 . + 0 ML1329 pafB conserved hypothetical protein ML1329, len: 331 aa. Conserved hypothetical protein. Similar to several proteins of undefined function including: Rhodococcus erythropolis TR:P72264 (EMBL:Z82004) (330 aa), Fasta scores: E(): 0, 57.2% identity in 327 aa overlap and Mycobacterium tuberculosis Rv2096c SW:YK96_MYCTU (Q10705) (332 aa), Fasta scores: E(): 0, 80.2% identity in 329 aa overlap. P54076 No conserved hypotheticals, intermediary metabolism and respiration P54076 Rv2096c Rv2096c AL450380.2 Mycobrowser_v4 CDS 3177822 3178823 . + 0 ML2655 fbpC2 PROTEINS OF THE ANTIGEN 85 COMPLEX ARE RESPONSIBLE FOR THE HIGH AFFINITY OF MYCOBACTERIA TO FIBRONECTIN. POSSESSES A MYCOLYLTRANSFERASE ACTIVITY REQUIRED FOR THE BIOGENESIS OF TREHALOSE DIMYCOLATE (CORD FACTOR), A DOMINANT STRUCTURE NECESSARY FOR MAINTAINING CELL WALL INTEGRITY. SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) ML2655, len: 333 aa. fbpC2, secreted antigen 85C, mycolyltransferase (EC 2.3.1.-). Previously sequenced and characterised: Mycobacterium leprae antigen 85-C precursor SW:A85C_MYCLE (Q05862) fasta scores: E(): 0, 100.0% in 333 aa. Similar to Rv0129c|P31953|A85C_MYCTU Antigen 85-C precursor (85C) from M. tuberculosis (340 aa), fasta scores: E(): 2.2e-119, (81.381% identity in 333 aa overlap). Also similar to ML0097 and ML2028 from M. leprae. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00756 Esterase, Putative esterase. Q05862 No lipid metabolism PF00756 Q05862 GO:0005576,GO:0008415 2.3.1.- Rv0129c Rv0129c AL450380.2 Mycobrowser_v4 CDS 3113033 3114727 . - 0 ML2608c ilvD PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) ML2608c, len: 564 aa. Probable ilvD, dihydroxy-acid dehydratase (EC 4.2.1.9). Similar to many Prokaryotic and Eukaryotic dihydroxy-acid dehydratases involved in valine and isoleucine biosynthesis e.g. Mycobacterium tuberculosis Rv0189c SW:ILVD_MYCTU (O07433) fasta scores: E(): 0, 90.0% identity in 560 aa, Saccharomyces cerevisiae dihydroxy-acid dehydratase, mitochondrial precursor ILV3 OR YJR016C OR J1450 SW:ILV3_YEAST (P39522) fasta scores: E(): 0, 48.5% identity in 555 aa. Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family. Contains PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. O06069 No intermediary metabolism and respiration PF00920 O06069 GO:0004160,GO:0005506,GO:0009097,GO:0009099,GO:0051539 4.2.1.9 Rv0189c Rv0189c AL450380.2 Mycobrowser_v4 CDS 1800426 1801359 . + 0 ML1493 PE7 PE-family protein (pseudogene) ML1493, len: 934 bp. Possible pseudogene of M. tuberculosis orthologue PE12|Rv1172c (927 bp) (Best blastx scores: 265). Yes PE/PPE Rv1172c Rv1172c AL450380.2 Mycobrowser_v4 CDS 1850794 1851060 . - 0 ML1534c PE8 PE family protein (pseudogene) ML1534c, len: 267 bp. Possible pseudogene of M. tuberculosis orthologue PE20|Rv1806 (300 bp) (Best blastx scores: 80). Yes PE/PPE Rv1806 Rv1806 AL450380.2 Mycobrowser_v4 CDS 2103811 2104015 . - 0 ML1743c PE9 PE-family protein (pseudogene) ML1743c, len: 205 bp. Possible pseudogene similar to M. tuberculosis PE-family protein (Best blastx scores: 79). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1305490 1305651 . + 0 ML1125 canA Conserved hypothetical protein (pseudogene) ML1125, len: 162 bp. Possible pseudogene of M. tuberculosis orthologue Rv1284 (492 bp) (Best blastx scores: 190). Yes intermediary metabolism and respiration Rv1284 Rv1284 AL450380.2 Mycobrowser_v4 CDS 1366635 1366998 . + 0 ML1168 mec Conserved hypothetical protein (pseudogene) ML1168, len: 364 bp. Possible pseudogene of M. tuberculosis orthologue Rv1334 (441 bp) (Best blastx scores: 127). Yes intermediary metabolism and respiration Rv1334 Rv1334 AL450380.2 Mycobrowser_v4 CDS 75826 76357 . - 0 ML0059B ML0059B hypothetical protein(pseudogene) ML0059B, len:531. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-26 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1582162 1583136 . + 0 ML1330 pafC Conserved hypothetical protein ML1330, len: 324 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv2095c SW:YK95_MYCTU (Q10704) (316 aa), Fasta scores: E(): 0, 74.2% identity in 322 aa overlap. also weakly similar to Bacillus subtilis putative transcriptional regulator TR:O34920 (EMBL:AF027868) (313 aa), Fasta scores: E(): 3.9e-05, 22.2% identity in 311 aa overlap. Contains a possible helix-turn-helix motif situated between residues 24..45 (+3.65 SD). P54075 No conserved hypotheticals, intermediary metabolism and respiration P54075 Rv2095c Rv2095c AL450380.2 Mycobrowser_v4 CDS 2332636 2333622 . + 0 ML1946 glpX conserved hypothetical protein ML1946, len: 328 aa. Conserved hypothetical protein. Similar to M. tuberculosis conserved hypothetical protein Rv1099c TR:O53447 (EMBL:AL021897) (328 aa), Fasta scores: E(): 0, 93.0% identity in 328 aa overlap, and to many others of the glpX family e.g. Escherichia coli GLPX protein SW:GLPX_ECOLI (P28860) (336 aa), Fasta scores: E(): 0, 41.7% identity in 321 aa overlap. Q9CBH9 No conserved hypotheticals, intermediary metabolism and respiration PF03320 Q9CBH9 GO:0006071 Rv1099c Rv1099c AL450380.2 Mycobrowser_v4 CDS 1903985 1904164 . + 0 ML1578 relB2 Conserved hypothetical protein (pseudogene) ML1578, len: 180 bp. Possible pseudogene of M. tuberculosis orthologue Rv2865 (282 bp) (Best blastx scores: 104) and also similar to Rv1247c. Yes virulence, detoxification, adaptation Rv2865 Rv2865 AL450380.2 Mycobrowser_v4 CDS 1904195 1904454 . + 0 ML1579 relE2 Conserved hypothetical protein (pseudogene) ML1579, len: 260 bp. Possible pseudogene of M. tuberculosis orthologue Rv2866 (264 bp) (Best blastx scores: 208). Yes virulence, detoxification, adaptation Rv2866 Rv2866 AL450380.2 Mycobrowser_v4 CDS 932052 933308 . + 0 ML0789 desA3 Possible linoleoyl-CoA desaturase (pseudogene) ML0789, len: 1257 bp. Possible pseudogene of M. tuberculosis orthologue Rv3229c (Best blastx scores: 343). Yes lipid metabolism Rv3229c Rv3229c AL450380.2 Mycobrowser_v4 CDS 3013317 3014186 . - 0 ML2530c espG3 ESX-1 SECRETION-ASSOCIATED PROTEIN ESPG3 ML2530c, len: 289 aa. ESX-1 secretion-associated protein, similar to Mycobacterium tuberculosis ESX-1 secretion-associated protein Rv0289 (espG3) TR:O53694 (EMBL:AL021930) fasta scores: 75.9% identity in 295 aa. Contains a probable helix-turn-helix motif at aa 175-196. Q9CD34 No cell wall and cell processes Q9CD34 GO:0003677 Rv0289 Rv0289 AL450380.2 Mycobrowser_v4 CDS 504794 505444 . + 0 ML0407 espD ESX-1 SECRETION-ASSOCIATED PROTEIN ESPD ML0407, len: 216 aa. ESX-1 secretion-associated protein, highly similar to Rv3614c|O06269|AL123456 ESX-1 secretion-associated protein from M. tuberculosis (184 aa), Fasta scores: (71.5% identity in 186 aa overlap) and to Rv3867|O69732|AL123456 protein from M. tuberculosis (183 aa), Fasta scores: E(): 2.1e-28, (51.4% identity in 175 aa overlap). Previously sequenced as Q49730|U00015 (216 aa), Fasta scores: (100.0% identity in 216 aa overlap). Also similar to ML0056 from M. leprae. Q49730 No cell wall and cell processes Q49730 Rv3614c Rv3614c AL450380.2 Mycobrowser_v4 CDS 72683 73686 . - 0 ML0058c espE ESX-1 SECRETION-ASSOCIATED PROTEIN ESPE(PSEUDOGENE) ML0058c, len: 1004 bp. Possible pseudogene of M. tuberculosis orthologue Rv3864 (1206 bp) (Best blastx scores: 110) Yes cell wall and cell processes Rv3864 Rv3864 AL450380.2 Mycobrowser_v4 CDS 55581 56699 . + 0 ML0045 espK ESX-1 SECRETION-ASSOCIATED PROTEIN ESPK. ALANINE AND PROLINE RICH PROTEIN(PSEUDOGENE) ML0045, len: 1119 bp. Possible pseudogene of M. tuberculosis orthologue Rv3879c (2187 bp) (Best blastx scores: 189) Yes cell wall and cell processes Rv3879c Rv3879c AL450380.2 Mycobrowser_v4 CDS 47271 48642 . + 0 ML0039 eccA2 ESX CONSERVED COMPONENT ECCA2. PROBABLE CBXX/CFQX FAMILY PROTEIN(PSEUDOGENE) ML0039, len: 1372 bp. Possible pseudogene of M. tuberculosis orthologue Rv3884c (1857 bp) (Best blastx scores: 288) Yes cell wall and cell processes Rv3884c Rv3884c AL450380.2 Mycobrowser_v4 CDS 43199 43699 . + 0 ML0036 eccD2 ESX CONSERVED COMPONENT ECCD2. PROBABLE TRANSMEMBRANE PROTEIN(PSEUDOGENE) ML0036, len: 501 bp. Possible pseudogene of M. tuberculosis orthologue Rv3887c (1527 bp) (Best blastx scores: 186) Yes cell wall and cell processes Rv3887c Rv3887c AL450380.2 Mycobrowser_v4 CDS 45397 46827 . + 0 ML0038 eccE2 ESX CONSERVED COMPONENT ECCE2. POSSIBLE MEMBRANE PROTEIN(PSEUDOGENE) ML0038, len: 1431 bp. Possible pseudogene of M. tuberculosis orthologue Rv3885c (1611 bp) (Best blastx scores: 128) Yes cell wall and cell processes Rv3885c Rv3885c AL450380.2 Mycobrowser_v4 CDS 75225 75590 . - 0 ML0059A ML0059A hypothetical protein(pseudogene) ML0059A, len:365. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-17 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1232042 1233172 . - 0 ML1068c glgA Putative glycosyl transferase (pseudogene) ML1068c, len: 1131 bp. Possible pseudogene of M. tuberculosis orthologue Rv1212c (1164 bp) (Best blastx scores: 834). Yes intermediary metabolism and respiration Rv1212c Rv1212c AL450380.2 Mycobrowser_v4 CDS 3244470 3244622 . + 0 ML2694A ML2694A hypothetical protein(pseudogene) ML2694A, len:152. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4E-50 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3244717 3246162 . + 0 ML2694B ML2694B glnQ; putative glutamine transport system permease protein / substrate-binding protein(pseudogene) ML2694B, len:1445. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-56 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1389492 1390165 . - 0 ML1187E ML1187E hypothetical protein(pseudogene) ML1187E (ML1187C), len:406. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-28 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1393365 1393771 . + 0 ML1189E ML1189E hypothetical protein(pseudogene) ML1189E (ML1189C), len:406. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-28 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1518858 1519217 . + 0 ML1275A ML1275A hypothetical protein(pseudogene) ML1275A, len:359. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-31 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1533805 1534116 . - 0 ML1287A ML1287A hypothetical protein(pseudogene) ML1287A, len:311. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2176405 2176794 . - 0 ML1798A ML1798A lipL; probable esterase(pseudogene) ML1798A, len:389. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-16 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2216985 2217599 . - 0 ML1830A ML1830A hypothetical protein(pseudogene) ML1830A, len:614. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-68 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1378330 1378828 . + 0 ML1179A ML1179A hypothetical protein(pseudogene) ML1179A, len:498. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-16 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1388186 1388599 . + 0 ML1187A ML1187A hypothetical protein(pseudogene) ML1187A, len:413. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-15 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1388579 1389379 . + 0 ML1187B ML1187B hypothetical protein(pseudogene) ML1187B, len:800. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-23 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 163770 164039 . - 0 ML0121c ML0121c Conserved hypothetical protein ML0121c, len: 89 aa. Conserved hypothetical protein. Shares region of weak similarity with Q9X7X8|AL049485 hypothetical protein SC6A5.32C from Streptomyces coelicolor (155 aa), Fasta scores: E(): 0.0056, (43.1% identity in 58 aa overlap). Q9CD93 No conserved hypotheticals Q9CD93 AL450380.2 Mycobrowser_v4 CDS 169585 170406 . + 0 ML0126 ML0126 Hypothetical protein ML0126, len: 273 aa. Hypothetical unknown protein. Q9CD90 No unknown Q9CD90 AL450380.2 Mycobrowser_v4 CDS 202307 202561 . - 0 ML0141c ML0141c Hypothetical protein ML0141c, len: 84 aa. Improbable CDS suggested by GC frameplot. Possibly the remains of a disrupted gene. Q9CD77 No unknown Q9CD77 AL450380.2 Mycobrowser_v4 CDS 1747951 1748595 . - 0 ML1454c nadD PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NICOTINATE MONONUCLEOTIDE ADENYLYLTRANSFERASE) (NAMN ADENYLYLTRANSFERASE) ML1454c, len: 214 aa. Probable nadD, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18). Similar to several e.g. Mycobacterium tuberculosis Rv2421c TR:O86328 (EMBL:Z81368) (211 aa), Fasta scores: E(): 0, 80.2% identity in 212 aa overlap. Q9CBZ8 No intermediary metabolism and respiration PF01467 Q9CBZ8 GO:0009435,GO:0004515,GO:0005524 2.7.7.18 Rv2421c Rv2421c AL450380.2 Mycobrowser_v4 CDS 993885 994268 . + 0 ML0837 ML0837 conserved hypothetical protein ML0837, len: 127 aa. Conserved hypothetical protein, similar in part to several aldolases e.g. SCI8.29C|Q9RJ24|AL132644 putative aldolase from Streptomyces coelicolor (240 aa) fasta scores: E(): 0.001, 32.5% identity in 120 aa. Q9CCG0 No conserved hypotheticals PF00596 Q9CCG0 GO:0046872 AL450380.2 Mycobrowser_v4 CDS 2218026 2218595 . - 0 ML1830B ML1830B hypothetical protein(pseudogene) ML1830B, len:569. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-39 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1131301 1131765 . + 0 ML0963 ML0963 hypothetical protein ML0963, len: 154 aa. Hypothetical unknown protein. Q9CCC4 No unknown Q9CCC4 AL450380.2 Mycobrowser_v4 CDS 1172602 1172877 . - 0 ML1001c ML1001c CONSERVED HYPOTHETICAL PROTEIN ML1001c, len: 91 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis Rv2722 TR:O33227 (EMBL:Z98209) (82 aa), Fasta scores: E(): 4.4e-05, 37.5% identity in 88 aa overlap. Q9CCB9 No conserved hypotheticals Q9CCB9 Rv2722 Rv2722 AL450380.2 Mycobrowser_v4 CDS 2487716 2487901 . + 0 ML2091 ML2091 hypothetical protein ML2091, len: 61 aa. Hypothetical unknown protein. Q9CBE6 No unknown Q9CBE6 AL450380.2 Mycobrowser_v4 CDS 2589798 2590049 . - 0 ML2178c ML2178c hypothetical protein ML2178c, len: 83 aa. Hypothetical unknown protein. Similar in part to Q8VJM5 Hypothetical protein MT2367 from M. tuberculosis CDC1551 (110 aa), fasta scores: E(): 0.093, (48.387% identity in 31 aa overlap). Q9CBD0 No unknown Q9CBD0 AL450380.2 Mycobrowser_v4 CDS 1803625 1805478 . - 0 ML1497c lpqW PROBABLE CONSERVED LIPOPROTEIN LPQW ML1497c, len: 617 aa. Probable lpqW, conserved lipoprotein. Similar to Mycobacterium tuberculosis Rv1166 TR:O50422 (EMBL:AL01018) (635 aa), Fasta scores: E(): 0, 80.4% identity in 632 aa overlap. Contains a possible N-terminal signal sequence. Q9CBX3 No cell wall and cell processes PF00496 Q9CBX3 GO:0005215,GO:0006810 Rv1166 Rv1166 AL450380.2 Mycobrowser_v4 CDS 1623030 1623983 . + 0 ML1362 ML1362 possible conserved secreted protein ML1362, len: 317 aa. Possible conserved secreted protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1698. Contains a possible N-terminal signal sequence. Q49894 No cell wall and cell processes Q49894 GO:0016021,GO:0006811,GO:0005886,GO:0009279 Rv1698 Rv1698 AL450380.2 Mycobrowser_v4 CDS 2688069 2688290 . - 0 ML2265c ML2265c hypothetical protein ML2265c, len: 73 aa. Hypothetical unknown protein. Q9CBB3 No unknown Q9CBB3 AL450380.2 Mycobrowser_v4 CDS 2331783 2332556 . - 0 ML1945c ML1945c conserved hypothetical protein ML1945c, len: 257 aa. Conserved hypothetical protein. Similar to M. tuberculosis conserved hypothetical protein Rv1100 TR:O53448 (EMBL:AL021897) (233 aa), Fasta scores: E(): 0, 63.8% identity in 257 aa overlap. Q7AQ15 No conserved hypotheticals Q7AQ15 Rv1100 Rv1100 AL450380.2 Mycobrowser_v4 CDS 2361226 2361573 . - 0 ML1976c ML1976c hypothetical protein ML1976c, len: 115 aa. Hypothetical unknown protein (questionable CDS). Q9CBH4 No unknown Q9CBH4 AL450380.2 Mycobrowser_v4 CDS 1390177 1390563 . - 0 ML1187D ML1187D hypothetical protein(pseudogene) ML1187D, len:386. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-35 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1391254 1392402 . + 0 ML1188A ML1188A hypothetical protein(pseudogene) ML1188A, len:1148. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-58 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2661051 2661782 . - 0 ML2242c ML2242c conserved hypothetical protein ML2242c, len: 243 aa. Conserved hypothetical protein, similar to Q52145|M23557 Mycobacterium fortuitum plasmid pAL5000 hypothetical 26.6 kda protein (255 aa), fasta scores: E(): 9.9e-05, (27.2% identity in 250 aa). Q7APX2 No conserved hypotheticals Q7APX2 GO:0003824 AL450380.2 Mycobrowser_v4 CDS 3250676 3253069 . + 0 ML2699 ML2699 putative secreted protein. ML2699, len: 797 aa. Putative secreted protein. Similar to Mycobacterium tuberculosis hypothetical 83.9 kda protein TR:O05436 (EMBL:Z94121) fasta scores: E(): 0, 72.4% in 803 aa. Contains a possible N-terminal signal sequence. Q9CCY0 No cell wall and cell processes, conserved hypotheticals Q9CCY0 Rv3909 Rv3909 AL450380.2 Mycobrowser_v4 CDS 3222411 3225413 . + 0 ML2678 ML2678 LONG CONSERVED HYPOTHETICAL PROTEIN ML2678, len: 1000 aa. Long conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 124.5 kda protein Rv2566 cy9c4.02c TR:Q50732 (EMBL:Z77250) fasta scores: E(): 0, 50.3% in 1128 aa. Q7APS1 No conserved hypotheticals PF08379,PF09899 Q7APS1 Rv2566 Rv2566 AL450380.2 Mycobrowser_v4 CDS 1392879 1393013 . - 0 ML1189A ML1189A hypothetical protein(pseudogene) ML1189A, len:134. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1393254 1393349 . + 0 ML1189B ML1189B hypothetical protein(pseudogene) ML1189B, len:95. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-08 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1552382 1552510 . - 0 ML1303A ML1303A probable conserved transmembrane protein(pseudogene) ML1303A, len:128. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1564256 1565016 . + 0 ML1311A ML1311A lpd; similar to mercury(II) reductase(pseudogene) ML1311A, len:760. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-55 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1603360 1603476 . - 0 ML1344A ML1344A hypothetical protein(pseudogene) ML1344A, len:116. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.025 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1393820 1395115 . + 0 ML1189D ML1189D hypothetical protein(pseudogene) ML1189D, len:1295. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-64 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1396216 1396335 . - 0 ML1190A ML1190A hypothetical protein(pseudogene) ML1190A, len:119. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1635899 1636015 . + 0 ML1374A ML1374A hypothetical protein(pseudogene) ML1374A, len:116. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.001 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1639014 1639343 . + 0 ML1375A ML1375A hypothetical protein(pseudogene) ML1375A, len:329. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-18 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1645736 1646507 . - 0 ML1380A ML1380A hypothetical protein(pseudogene) ML1380A, len:771. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-45 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1646508 1646633 . - 0 ML1380B ML1380B hypothetical protein(pseudogene) ML1380B, len:125. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1429774 1430242 . - 0 ML1209A ML1209A hypothetical protein(pseudogene) ML1209A, len:468. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1431406 1431580 . - 0 ML1210A ML1210A glgZ; maltooligosyl trehalose trehalohydrolase(pseudogene) ML1210A, len:174. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-07 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1646678 1647268 . - 0 ML1380C ML1380C hypothetical protein(pseudogene) ML1380C, len:590. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-23 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1655574 1655788 . - 0 ML1383A ML1383A hypothetical protein(pseudogene) ML1383A, len:214. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-14 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1108030 1108169 . - 0 ML0937c ML0937c Possible transposase remnant (pseudogene) ML0937c, len: 140 bp. Possible transposase remnant, some similarity to Q9RBZ3 transposase from Pseudomonas syringae (357 aa), (blastx scores: 51) and to Q44454|Z18270 transposase from Agrobacterium tumefaciens (366 aa), (blastx scores: 45). Belongs to the LEPREP family of dispersed repeats (see citation below). Yes unknown AL450380.2 Mycobrowser_v4 CDS 1499659 1499766 . + 0 ML1254A ML1254A hypothetical protein(pseudogene) ML1254A, len:107. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1656073 1656225 . - 0 ML1383B ML1383B hypothetical protein(pseudogene) ML1383B, len:152. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1671277 1671399 . - 0 ML1392A ML1392A hypothetical protein(pseudogene) ML1392A, len:122. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.001 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2927718 2928005 . - 0 ML2453c ML2453c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN ML2453c, len: 95 aa. Possible conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical Rv0476 precursor MTCY20g9.02 SW:Y476_MYCTU (Q11143) fasta scores: E(): 1.6e-24, 83.9% identity in 87 aa. Contains possible membrane spanning hydrophobic domains. Q9CB43 No cell wall and cell processes PF10724 Q9CB43 GO:0016021 Rv0476 Rv0476 AL450380.2 Mycobrowser_v4 CDS 7318 11067 . + 0 ML0006 gyrA DNA Gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. This DNA Gyrase is made up of two chains. The A chain is responsible for DNA breakage and rejoining and the B chain catalyzes ATP hydrolysis [Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA]. Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) ML0006, len: 1249 aa. Probable gyrA, DNA gyrase subunit A (EC 5.99.1.3) (see citations below), highly similar to other Mycobacterial DNA GYRASES SUBUNIT A e.g. Rv0006|GYRA_MYCTU|Q07702 from M. tuberculosis (838 aa), Fasta scores: E(): 0, (91.1% identity in 695 aa overlap) and to GYRA_MYCSM|P48354 from Mycobacterium smegmatis (842 aa), Fasta scores: E(): 0, (88.2% identity in 692 aa overlap). Previously sequenced as GYRA_MYCLE|Q57532 (1273 aa), Fasta scores: E(): 0, (99.9% identity in 1246 aa overlap). Contains a probable intein from aa 131 to 550 inclusive. Contains 2 Pfam matches to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A. Contains PS00018 EF-hand calcium-binding domain. Contains PS00881 Protein splicing signature. Q57532 No information pathways PF00521,PF03989 Q57532 GO:0003918,GO:0006265,GO:0005694,GO:0004519,GO:0016539,GO:0005524 5.99.1.3 Rv0006 Rv0006 AL450380.2 Mycobrowser_v4 CDS 547313 547789 . + 0 ML0447 ML0447 Conserved hypothetical protein ML0447, len: 158 aa. Conserved hypothetical protein. Similar to region of cytochrome P450s e.g. CPXB_BACME|P14779|CYP102A1 cytochrome P450(BM-3) from Bacillus megaterium (1048 aa), Fasta scores: E(): 0.00033, (31.8% identity in 132 aa overlap). Previously sequenced as O07142|Z96801 (126 aa), Fasta scores: E(): 0, (99.2% identity in 126 aa overlap). Q9CCU2 No conserved hypotheticals Q9CCU2 GO:0020037,GO:0005506,GO:0004497,GO:0009055 AL450380.2 Mycobrowser_v4 CDS 15993 16541 . + 0 ML0011 ppiA Probable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A) (Rotamase A) ML0011, len: 182 aa. Probable ppiA, peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8)(see citations below), similar to Rv0009|CYPA_MYCTU|P71578 ppiA from M. tuberculosis (182 aa), Fasta scores: E(): 0, (90.1% identity in 182 aa overlap) and P77949|U64692 ScCypB peptidyl-prolyl cis-trans isomerase B from Streptomyces chrysomallus (175 aa), Fasta scores: E(): 0, (63.3% identity in 166 aa overlap). Also similar to ML0492 from M. leprae. Contains Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase. Belongs to the cyclophilin-type PPIase family. Q9CDE9 No information pathways PF00160 Q9CDE9 GO:0003755,GO:0006457,GO:0005737 5.2.1.8 Rv0009 Rv0009 AL450380.2 Mycobrowser_v4 CDS 212897 213010 . - 0 ML0150A ML0150A hypothetical protein(pseudogene) ML0150A, len:113. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-07 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 18325 19023 . + 0 ML0015 trpG Possibly involved in biosynthesis of tryptophan (at the first step). Thought to be a tetramer of two components I and two components II: component I (ML1269/trpE) catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II (ML0015/trpG) provides glutamine aminotranferase activity. Possibly participates in the tryptophan-dependent indole-3-acetic acid production [Catalytic activity: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate]. Possible anthranilate synthase component II TrpG (glutamine amidotransferase) ML0015, len: 232 aa. Possible trpG, anthranilate synthase component II (glutamine amidotransferase) (EC 4.1.3.27), equivalent to Rv0013|Q50183|Z70722 possible trpG, anthranilate synthase component II from M. tuberculosis (232 aa), Fasta scores: E(): 0, (100.0% identity in 232 aa overlap); and similar to others e.g. TRPG_AZOBR|P26922 trpG from Azospirillum brasilense (196 aa), Fasta scores: E(): 0, (56.1% identity in 187 aa overlap). Previously sequenced as Q50183. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. Similarity to other type-1 glutamine aminotransferase domains. Note that previously known as pabA. Q50183 No intermediary metabolism and respiration PF00117 Q50183 GO:0009058,GO:0006541,GO:0016740,GO:0004049 Rv0013 Rv0013 AL450380.2 Mycobrowser_v4 CDS 1718738 1719268 . + 0 ML1432A ML1432A hypothetical protein(pseudogene) ML1432A, len:530. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-23 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 34033 34638 . - 0 ML0029c ML0029c Possible transmembrane protein ML0029c, len: 201 aa. Possible transmembrane protein. Contains a region similar to part of several bacterial hypothetical membrane proteins e.g. Q9ZBW2|AL034443 putative transmembrane protein SC4B5.06 from Streptomyces coelicolor (345 aa), Fasta scores: E(): 2.4e-14, (54.1% identity in 109 aa overlap). The coding frame predicted by GC frameplot changes to either side of this region of similarity, suggesting that an ancestral CDS was disrupted. Given this, ML0029 may not be functional. Contains hydrophobic, possible membrane-spanning regions. Q9CDE0 No cell wall and cell processes Q9CDE0 AL450380.2 Mycobrowser_v4 CDS 34750 35091 . - 0 ML0030c ML0030c Possible conserved transmembrane protein ML0030c, len: 113 aa. Possible conserved transmembrane protein, highly similar to Rv0039c|P71696|AL123456 possible conserved transmembrane protein from M. tuberculosis (115 aa), Fasta scores: E(): 2.2e-25, (63.2% identity in 114 aa overlap). Previously sequenced as O32871|Z70722 (113 aa), Fasta scores: E(): 0, (100.0% identity in 113 aa overlap). Contains hydrophobic, possible membrane-spanning regions. O32871 No cell wall and cell processes O32871 GO:0005886,GO:0016021 Rv0039c Rv0039c AL450380.2 Mycobrowser_v4 CDS 88741 89106 . - 0 ML0067c hns Possible histone-like protein Hns ML0067c, len: 121 aa. Possible hns, histone-like protein, similar to Rv3852|P96225|AL123456 hns, HU-histone protein from M. tuberculosis (134 aa), Fasta scores: E(): 6.1e-12, (51.5% identity in 134 aa overlap). Contains PAKKX repeats similar to those in histone H1 proteins. Q9CDD1 No information pathways Q9CDD1 Rv3852 Rv3852 AL450380.2 Mycobrowser_v4 CDS 91913 92446 . - 0 ML0071c ML0071c Conserved hypothetical protein ML0071c, len: 177 aa. Conserved hypothetical protein, equivalent to Rv3847|P96230|AL123456) hypothetical protein from M. tuberculosis (177 aa), Fasta scores: E(): 0, (96.6% identity in 177 aa overlap); and Q9F9R0 HYPOTHETICAL 18.5 KDA PROTEIN from Mycobacterium paratuberculosis (177 aa). Q9CDC7 No conserved hypotheticals Q9CDC7 Rv3847 Rv3847 AL450380.2 Mycobrowser_v4 CDS 94092 95126 . + 0 ML0073 ML0073 Probable conserved transmembrane protein ML0073, len: 344 aa. Probable conserved transmembrane protein, highly similar to Rv3843c|P96235|Z83864 transmembrane protein from M. tuberculosis (342 aa), Fasta scores: E(): 0, (63.0% identity in 349 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDC6 No cell wall and cell processes Q9CDC6 Rv3843c Rv3843c AL450380.2 Mycobrowser_v4 CDS 239809 239958 . - 0 ML0172A ML0172A hypothetical protein(pseudogene) ML0172A, len:149. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 99390 100085 . + 0 ML0079 ML0079 Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) ML0079, len: 231 aa. Probable phosphoglycerate mutase (EC 5.4.2.-), highly similar to Rv3837c|P96241|AL123456 probable phosphoglycerate mutase from M. tuberculosis (232 aa), Fasta scores: E(): 0, (71.6% identity in 232 aa overlap). Similar to Q9ZAX0|U73808 pgm, 2,3-PDG dependent phosphoglycerate mutase from Amycolatopsis methanolica (205 aa), Fasta scores: E(): 9.3e-24, (39.7% identity in 204 aa overlap). Also similar to ML1452 from M. leprae. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. Q9CDC3 No intermediary metabolism and respiration PF00300 Q9CDC3 Rv3837c Rv3837c AL450380.2 Mycobrowser_v4 CDS 110329 111174 . + 0 ML0089 ML0089 Conserved hypothetical protein ML0089, len: 281 aa. Conserved hypothetical protein, highly similar to Rv3813c|O07810|AL123456 conserved hypothetical protein from M. tuberculosis (273 aa), Fasta scores: E(): 0, (80.4% identity in 271 aa overlap). Similar to many other bacterial hypothetical proteins. Contains Pfam match to entry PF00592 DUF3, Cof family. Q9CDB9 No conserved hypotheticals PF08282 Q9CDB9 GO:0008152,GO:0016787 Rv3813c Rv3813c AL450380.2 Mycobrowser_v4 CDS 114130 115371 . + 0 ML0092 glf Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) ML0092, len: 413 aa. Probable glf (alternate gene name: ceoA), UDP-galactopyranose mutase (EC 5.4.99.9) (see citations below), highly similar to Rv3809c|O06934|U96128 glf, UDP-galactopyranose mutase from M. tuberculosis (399 aa), Fasta scores: E(): 0, (86.6% identity in 396 aa overlap). Also similar to others e.g. GLF_ECOLI|P37747 glf, UDP-galactopyranose mutase from Escherichia coli (367 aa), Fasta scores: E(): 0, (43.1% identity in 378 aa overlap). Q9CDB8 No cell wall and cell processes PF01266,PF03275 Q9CDB8 GO:0005488,GO:0008152,GO:0016491,GO:0008767 Rv3809c Rv3809c AL450380.2 Mycobrowser_v4 CDS 366385 367263 . + 0 ML0285 ML0285 Probable conserved membrane protein ML0285, len: 292 aa. Probable conserved membrane protein, similar to Rv0361|O06311|AL123456 probable conserved membrane protein from M. tuberculosis (275 aa), Fasta scores: E(): 0, (58.6% identity in 292 aa overlap). Previously sequenced as O69599|AL023514 (292 aa), Fasta scores: E(): 0, (100.0% identity in 292 aa overlap). Contains hydrophobic, possible membrane-spanning region. Q7AQK2 No cell wall and cell processes Q7AQK2 Rv0361 Rv0361 AL450380.2 Mycobrowser_v4 CDS 118819 120768 . + 0 ML0096 ML0096 Probable conserved transmembrane protein ML0096, len: 649 aa. Probable conserved transmembrane protein, highly similar to Rv3805c|O53582|AL123456 probable transmembrane protein from M. tuberculosis (627 aa), Fasta scores: E(): 0, (80.9% identity in 629 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDB4 No cell wall and cell processes Q9CDB4 Rv3805c Rv3805c AL450380.2 Mycobrowser_v4 CDS 126518 131872 . + 0 ML0101 pks13 Polyketide synthase Pks13 ML0101, len: 1784 aa. Probable pks13, polyketide synthase (EC undetermined), similar to many polyketide synthases from M. tuberculosis e.g. Rv3800c|O53579 pks13, polyketide synthase (1733 aa), Fasta scores: E(): 0, (83.6% identity in 1748 aa overlap); and PPSA_MYCTU|Q10977 ppsA, phenolpthiocerol synthesis polyketide synthase (1876 aa), Fasta scores: E(): 0, (36.1% identity in 1277 aa overlap). Similar to many others e.g. AAF71766|AF263912 nystatin biosynthesis polyketide synthase from Streptomyces noursei nysI (9477 aa), Fasta scores: E(): 0, (33.4% identity in 1215 aa overlap). Also similar to ML0135, ML0139, ML1229, ML2353, ML2354, ML2355, ML2356, and ML2357 from M. leprae. Similar to ML2607c a possible pseudogene similar to M. tuberculosis pks13. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00975 Thioesterase, Thioesterase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q9CDB1 No lipid metabolism PF00109,PF00550,PF00698,PF00975,PF02801 Q9CDB1 GO:0009058,GO:0048037,GO:0016788,GO:0016740,GO:0000036 Rv3800c Rv3800c AL450380.2 Mycobrowser_v4 CDS 139821 143156 . - 0 ML0105c embA Involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). Polymerizes arabinose into the arabinan of arabiogalactan [Catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]. Probable integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) ML0105c, len: 1111 aa. Probable embA, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), similar to Rv3794|Q50394|AL123456 embA, indolylacetylinositol arabinosyltransferase from M. tuberculosis (1094 aa), Fasta scores: E(): 0, (64.2% identity in 1108 aa overlap); and to other putative mycobacterial arabinosyltransferases. Also similar to ML0104 and ML0106 from M. leprae. Involved in resistance to ethambutol in M. tuberculosis. In M. tuberculosis embA is thought to be regulated by embR, but this regulator doesn't exist in M. leprae. Contains hydrophobic, possible membrane-spanning regions. Q9CDA8 No cell wall and cell processes PF04602 Q9CDA8 GO:0016021,GO:0009252,GO:0005886,GO:0016763,GO:0007047 2.4.2.- Rv3794 Rv3794 AL450380.2 Mycobrowser_v4 CDS 2308197 2308286 . - 0 ML1923C ML1923C hypothetical protein(pseudogene) ML1923C, len:89. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 144115 147327 . - 0 ML0106c embC Involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). Polymerizes arabinose into the arabinan of arabiogalactan [Catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]. Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) ML0106c, len: 1070 aa. Probable embC, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), highly similar to Rv3793|P72059|AL123456 embC, indolylacetylinositol arabinosyltransferase from M. tuberculosis (1094 aa), Fasta scores: E(): 0, (82.8% identity in 1075 aa overlap); and to other putative mycobacterial arabinosyltransferases. Also similar to ML0104 and ML0105 from M. leprae. Involved in resistance to ethambutol in M. tuberculosis. Contains hydrophobic, possible membrane-spanning regions. Q9CDA7 No cell wall and cell processes PF04602 Q9CDA7 GO:0016021,GO:0009252,GO:0005886,GO:0016763,GO:0007047 2.4.2.- Rv3793 Rv3793 AL450380.2 Mycobrowser_v4 CDS 155413 155961 . - 0 ML0115c ML0115c Conserved hypothetical protein ML0115c, len: 182 aa. Conserved hypothetical protein, highly similar to Rv3780|Y1I0_MYCTU|P72046 conserved hypothetical protein from M. tuberculosis (178 aa), Fasta scores: E(): 0, (82.9% identity in 170 aa overlap); and to Q9XA56|AL096822 hypothetical protein SCGD3.23C from Streptomyces coelicolor (179 aa), Fasta scores: E(): 0, (65.7% identity in 178 aa overlap). Note start changed since original submission. Q9CD99 No conserved hypotheticals PF10759 Q9CD99 Rv3780 Rv3780 AL450380.2 Mycobrowser_v4 CDS 151578 151949 . - 0 ML0110c ML0110c Probable conserved transmembrane protein ML0110c, len: 123 aa. Probable conserved transmembrane protein, highly similar to Rv3789|Y1I9_MYCTU|P72055 hypothetical protein from M. tuberculosis (121 aa), Fasta scores: E(): 0, (73.0% identity in 122 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDA3 No cell wall and cell processes PF04138 Q9CDA3 GO:0005886,GO:0000271,GO:0006810,GO:0016021 Rv3789 Rv3789 AL450380.2 Mycobrowser_v4 CDS 153663 154514 . - 0 ML0113c ML0113c Possible L-rhamnosyltransferase ML0113c, len: 283 aa. Possible L-rhamnosyltransferase (EC 2.4.1.-), highly similar to Rv3782|P72048 possible L-rhamnosyltransferase from M. tuberculosis (304 aa), FASTA scores: opt: 1583, E(): 9.3e-96, (81.6% identity in 277 aa overlap). Similar to Q8NTV4 predicted glycosyltransferases from Corynebacterium glutamicum ATCC (313 aa), FASTA scores: opt: 1170, E(): 4.4e-73, (63.1% identity in 279 aa overlap); and other putative transferases. Note that previously known as rfbE. Q9CDA1 No cell wall and cell processes PF00535 Q9CDA1 GO:0016740 Rv3782 Rv3782 AL450380.2 Mycobrowser_v4 CDS 160495 161730 . - 0 ML0119c lipE Probable lipase LipE ML0119c, len: 411 aa. Probable lipE, hydrolase lipase (EC 3.1.-.-), highly similar to Rv3775|P72041|AL123456 probable lipE, lipase from M. tuberculosis (415 aa), Fasta scores: E(): 0, (84.7% identity in 406 aa overlap) . Similar to bacterial esterases e.g. O87861|Z15137 estA, esterase A from Streptomyces chrysomallus (389 aa), Fasta scores: E(): 2.6e-18, (29.9% identity in 348 aa overlap). Q9CD95 No intermediary metabolism and respiration PF00144 Q9CD95 GO:0016787 Rv3775 Rv3775 AL450380.2 Mycobrowser_v4 CDS 222650 223942 . + 0 ML0159 ML0159 Probable conserved integral membrane protein ML0159, len: 430 aa. Probable conserved integral membrane protein, highly similar to Rv0955|Y955_MYCTU|P71555 integral membrane protein from M. tuberculosis (455 aa), Fasta scores: E(): 0, (75.9% identity in 419 aa overlap). Previously sequenced as Q9Z5H7|AL035500 (430 aa), Fasta scores: E(): 0, (99.8% identity in 430 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQN5 No cell wall and cell processes Q7AQN5 Rv0955 Rv0955 AL450380.2 Mycobrowser_v4 CDS 218458 219639 . + 0 ML0155 sucC Probable succinyl-CoA synthase, (beta chain) SucC (SCS-beta) ML0155, len: 393 aa. Probable sucC, succinyl-CoA synthetase, beta chain (EC 6.2.1.5), highly similar to Rv0951|SUCC_MYCTU|P71559 sucC, succinyl-CoA synthetase beta chain from M. tuberculosis (387 aa), Fasta scores: E(): 0, (86.7% identity in 391 aa overlap). Similar to many e.g. SUCC_THEFL|P25126 sucC, succinyl-CoA synthase beta chain from Thermus aquaticus (378 aa), Fasta scores: E(): 0, (48.7% identity in 384 aa overlap). Previously sequenced as Q9Z5H8 |AL035500 (393 aa), Fasta scores: E(): 0, (100.0% identity in 393 aa overlap). Contains Pfam match to entry PF00549 ligase-CoA, CoA-ligases. Contains Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain. Contains PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. Q9Z5H8 No intermediary metabolism and respiration PF00549,PF08442 Q9Z5H8 GO:0000287,GO:0030145,GO:0004775,GO:0006099,GO:0005524 6.2.1.5 Rv0951 Rv0951 AL450380.2 Mycobrowser_v4 CDS 298516 298992 . + 0 ML0227 ML0227 Probable conserved secreted or membrane protein ML0227, len: 158 aa. Probable conserved secreted or membrane protein, highly similar to Rv3605c|O06277|AL123456 conserved secreted or membrane protein from M. tuberculosis (158 aa), Fasta scores: E(): 0, (85.4% identity in 158 aa overlap). Previously sequenced as O69527|AL023093 (158 aa), Fasta scores: E(): 0, (100.0% identity in 158 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQL4 No cell wall and cell processes Q7AQL4 Rv3605c Rv3605c AL450380.2 Mycobrowser_v4 CDS 241217 242776 . + 0 ML0175 mprB Probable two component sensor kinase MprB ML0175, len: 519 aa. Probable mprB, two component sensor kinase, transmembrane protein (EC 2.7.3.-) (see citation below), highly similar to Rv0982|O53895|AL123456 mprB, two component sensor kinase from M. tuberculosis (504 aa), Fasta scores: E(): 0, (81.0% identity in 521 aa overlap); and similar to many others e.g. COPS_PSESM|Q02541 copS, sensor protein involved in activation of copper resistance from Pseudomonas syringae (487 aa), Fasta scores: E(): 1.2e-18, (27.9% identity in 427 aa overlap). Also similar to ML0774, ML2124 and ML2440 from M. leprae. Previously sequenced as Q9Z5G7|AL035500) (519 aa), Fasta scores: E(): 0, (100.0% identity in 519 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains Pfam match to entry PF00512 signal, Histidine kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9Z5G7 No regulatory proteins PF00512,PF00672,PF02518 Q9Z5G7 GO:0016021,GO:0000287,GO:0030145,GO:0009405,GO:0018106,GO:0004721,GO:0005886,GO:0006950,GO:0000155,GO:0000160,GO:0005524 3.1.3.-,2.7.13.3 Rv0982 Rv0982 AL450380.2 Mycobrowser_v4 CDS 246049 246348 . - 0 ML0180c ML0180c Conserved hypothetical Serine rich protein ML0180c, len: 99 aa. Conserved hypothetical ser-rich protein (especially in C-terminus), highly similar to Rv0991c|O05574|AL123456 hypothetical protein with Ser-rich C-terminus from M. tuberculosis (110 aa), Fasta scores: E(): 1.1e-23, (78.5% identity in 93 aa overlap). Similar to other bacterial Ser-rich hypothetical proteins e.g. CAB90971|AL355832 hypothetical protein SCE22.04 from Streptomyces coelicolor (110 aa), Fasta scores: E(): 2.6e-15, (54.5% identity in 99 aa overlap). Previously sequenced as Q9Z5G3|AL035500 (120 aa), Fasta scores: E(): 1.1e-32, (100.0% identity in 99 aa overlap). Q9CD66 No conserved hypotheticals PF09723 Q9CD66 Rv0991c Rv0991c AL450380.2 Mycobrowser_v4 CDS 410355 410852 . + 0 ML0320 ML0320 Possible transcription factor ML0320, len: 165 aa. Possible transcriptional factor, highly similar to Rv3583c|O53568|AL123456 possible transcription factor from M. tuberculosis (162 aa), Fasta scores: E(): 0, (97.5% identity in 162 aa overlap). Similar to many putative bacterial transcription factors e.g. Q9L0Q9|SCD8A.05 putative transcriptional factor regulator from Streptomyces coelicolor A3(2) (160 aa), and weak similarity to Q50887|Z56280 carD, transcription factor from Myxococcus xanthus (316 aa), Fasta scores: E(): 9.1e-13, (31.2% identity in 154 aa overlap). Q9CCW7 No regulatory proteins PF02559 Q9CCW7 GO:0003700,GO:0006355 Rv3583c Rv3583c AL450380.2 Mycobrowser_v4 CDS 246423 247016 . - 0 ML0181c ML0181c Conserved hypothetical protein ML0181c, len: 197 aa. Conserved hypothetical protein, highly similar to Rv0992c|O05575|AL123456 conserved hypothetical protein from M. tuberculosis (197 aa), Fasta scores: E(): 0, (72.6% identity in 197 aa overlap). Similar to many hypothetical proteins and shows weak similarity to methenyltetrahydrofolate synthetases e.g. Q8NS05 5-formyltetrahydrofolate cyclo-ligase from Corynebacterium glutamicum (190 aa), Fasta scores: E(): 3.3e-15, (35.1% identity in 188 aa overlap). Previously sequenced as Q9Z5G2|AL035500 (197 aa), Fasta scores: E(): 0, (100.0% identity in 197 aa overlap). Contains Pfam match to entry PF01812 5-FTHF_cyc-lig, 5-formyltetrahydrofolate cyclo-ligase. Q7AQM9 No conserved hypotheticals PF01812 Q7AQM9 GO:0005524,GO:0009396,GO:0030272 Rv0992c Rv0992c AL450380.2 Mycobrowser_v4 CDS 258646 259491 . + 0 ML0193 ML0193 Conserved hypothetical protein ML0193, len: 281 aa. Conserved hypothetical protein, highly similar to Rv1003|YA03_MYCTU|O05588 conserved hypothetical protein from M. tuberculosis (285 aa), Fasta scores: E(): 0, (74.0% identity in 277 aa overlap). Similar to many bacterial hypothetical proteins e.g. Q9RKD4|AL132674 conserved hypothetical protein SCE87.04C from Streptomyces coelicolor (286 aa), Fasta scores: E(): 0, (50.5% identity in 277 aa overlap). Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. Q9CD60 No conserved hypotheticals PF00590 Q9CD60 GO:0008168,GO:0008152 Rv1003 Rv1003 AL450380.2 Mycobrowser_v4 CDS 249407 250051 . + 0 ML0184 rimJ Possible ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) ML0184, len: 214 aa. Possible rimJ, ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), highly similar to Rv0995|O05578|AL123456 rimJ, ribosomal-protein-alanine acetyltransferase from M. tuberculosis (203 aa), Fasta scores: E(): 0, (86.0% identity in 200 aa overlap). Similar to RIMJ_ECOLI|P09454 rimJ, ribosomal-protein-alanine acetyltransferase from Escherichia coli (194 aa), Fasta scores: E(): 9.4e-12, (28.0% identity in 189 aa overlap); and to many other acetyltransferases. Previously sequenced as Q9Z5F9|AL035500 (218 aa), Fasta scores: E(): 0, (100.0% identity in 214 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. Seems to belong to the acetyltransferase family, rimJ subfamily. Q9CD65 No information pathways PF00583 Q9CD65 GO:0008152,GO:0008080 Rv0995 Rv0995 AL450380.2 Mycobrowser_v4 CDS 276707 277777 . - 0 ML0205c ML0205c Probable conserved integral membrane protein ML0205c, len: 356 aa. Probable conserved integral membrane protein, highly similar to Rv3629c|O06378|AL123456 conserved integral membrane protein from M. tuberculosis (365 aa), Fasta scores: E(): 0, (66.2% identity in 361 aa overlap). Similar to other bacterial hypothetical membrane proteins e.g. CAB92842|AL356892 putative integral membrane protein SCC8A.24C from Streptomyces coelicolor (380 aa), Fasta scores: E(): 1e-21, (47.5% identity in 377 aa overlap). Previously sequenced as O69543|AL023093 (356 aa), Fasta scores: E(): 0, (100.0% identity in 356 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQL9 No cell wall and cell processes PF04332 Q7AQL9 Rv3629c Rv3629c AL450380.2 Mycobrowser_v4 CDS 279051 279770 . + 0 ML0207 ML0207 Possible transferase (possibly glycosyltransferase) ML0207, len: 239 aa. Possible transferase (EC 2.-.-.-), more specifically a glycosyltransferase (EC 2.4.-.-), highly similar to Rv3631|O06376|AL123456 possible glycosyltransferase from M. tuberculosis (241 aa), Fasta scores: E(): 0, (80.8% identity in 239 aa overlap). Similar to many bacterial hypothetical proteins and dolichyl-phosphate mannose synthases. Previously sequenced as O69542|PS50167 (239 aa), Fasta scores: E(): 0, (99.6% identity in 239 aa overlap). Also similar to ML1440 from M. leprae. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Q7AQL8 No intermediary metabolism and respiration PF00535 Q7AQL8 GO:0016740 Rv3631 Rv3631 AL450380.2 Mycobrowser_v4 CDS 284580 285551 . + 0 ML0213 mesJ Possible cell cycle protein MesJ ML0213, len: 323 aa. Possible mesJ, cell cycle protein, highly similar to Rv3625c|Y0C5_MYCTU|O06382 possible mesJ, cell cycle protein from M. tuberculosis (323 aa), Fasta scores: E(): 0, (78.0% identity in 327 aa overlap). Similar to many others e.g. MESJ_ECOLI|P52097 mesJ, putative cell cycle protein from Escherichia coli (432 aa), Fasta scores: E(): 3.9e-12, (33.0% identity in 279 aa overlap). Previously sequenced as Y0C5_MYCLE|O69538 (323 aa), Fasta scores: E(): 0, (100.0% identity in 323 aa overlap). Belongs to the UPF0072 (mesJ/ycf62) family. O69538 No cell wall and cell processes PF01171 O69538 GO:0005737,GO:0016879,GO:0006400,GO:0006412,GO:0005524 6.3.4.- Rv3625c Rv3625c AL450380.2 Mycobrowser_v4 CDS 297543 297941 . + 0 ML0225 folB Involved in folate biosynthesis. Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin [Catalytic activity: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde]. Probable dihydroneopterin aldolase FolB (DHNA) ML0225, len: 132 aa. Probable folB, dihydroneopterin aldolase (EC 4.1.2.25), highly similar to Rv3607c|FOLB_MYCTU|O06275 probable folB, dihydroneopterin aldolase from M. tuberculosis (133 aa), Fasta scores: E(): 0, (74.8% identity in 131 aa overlap). Similar to many others e.g. FOLB_STAAU|P56740 folB, dihydroneopterin aldolase from Staphylococcus aureus (121 aa), Fasta scores: E(): 1.9e-09, (33.9% identity in 121 aa overlap). Previously sequenced as FOLB_MYCLE|O69529 (132 aa), Fasta scores: E(): 0, (100.0% identity in 132 aa overlap). Contains Pfam match to entry PF02152 FolB, Dihydroneopterin aldolase. Belongs to the DHNA family. O69529 No intermediary metabolism and respiration PF02152 O69529 GO:0046656,GO:0004150 4.1.2.25 Rv3607c Rv3607c AL450380.2 Mycobrowser_v4 CDS 302404 302832 . + 0 ML0231 panD Probable aspartate-1-decarboxylase precursor PanD (aspartate alpha-decarboxylase) ML0231, len: 142 aa. Probable panD, aspartate 1-decarboxylase (EC 4.1.1.11), highly similar to PAND_MYCTU|Z95557 panD, aspartate-1-decarboxylase from M. tuberculosis (139 aa), Fasta scores: E(): 0, (82.9% identity in 140 aa overlap); and to several others e.g. Q9X4N0|AF116184 panD, L-aspartate-alpha-decarboxylase precursor from Corynebacterium glutamicum (136 aa), Fasta scores: E(): 9.3e-29, (68.8% identity in 128 aa overlap). Q9CD57 No intermediary metabolism and respiration PF02261 Q9CD57 GO:0004068,GO:0005488,GO:0005737,GO:0015940,GO:0006523 4.1.1.11 Rv3601c Rv3601c AL450380.2 Mycobrowser_v4 CDS 2238978 2239394 . - 0 ML1856c rplP PROBABLE 50S RIBOSOMAL PROTEIN L16 RPLP ML1856c, len: 138 aa. Probable rplP, 50S ribosomal protein L16. Similar to M. tuberculosis 50S ribosomal protein L16 Rv0708 SW:RL16_MYCTU (P95056) (138 aa), Fasta scores: E(): 0, 96.4% identity in 138 aa overlap. Contains Pfam match to entry PF00252 Ribosomal_L16, Ribosomal protein L16. Contains PS00701 Ribosomal protein L16 signature 2. O32988 No information pathways PF00252 O32988 GO:0005840,GO:0003735,GO:0000049,GO:0006412,GO:0019843 Rv0708 Rv0708 AL450380.2 Mycobrowser_v4 CDS 322399 323055 . - 0 ML0246c lpqT Probable conserved lipoprotein LpqT ML0246c, len: 218 aa. Probable lpqT, conserved lipoprotein, similar to Rv1016c|LPQT_MYCTU|P96384 lpqT, probable lipoprotein from M. tuberculosis (226 aa), Fasta scores: E(): 0, (67.1% identity in 213 aa overlap). Also similar to Rv0040c|PR28_MYCTU|P71697 MTC28, proline rich 28 kDa antigen precursor from M. tuberculosis (311 aa), Fasta scores: E(): 1.3e-10, (33.3% identity in 159 aa overlap). Also similar to ML0031 from M. leprae, except at N-terminus. Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CD47 No cell wall and cell processes PF10738 Q9CD47 GO:0005886 Rv1016c Rv1016c AL450380.2 Mycobrowser_v4 CDS 293693 296065 . + 0 ML0222 ftsH Probable membrane-bound protease FtsH (cell division protein) ML0222, len: 790 aa. Probable ftsH, membrane-bound protease (cell division protein) (EC 3.4.24.-) (see citations below), highly similar to Rv3610c|FTSH_MYCTU|P96942 ftsH, membrane-bound protease from M. tuberculosis (760 aa), Fasta scores: E(): 0, (87.2% identity in 790 aa overlap). Similar to many others e.g. FTSH_ECOLI|P28691 ftsH, cell division protein from Escherichia coli (644 aa), Fasta scores: E(): 0, (49.3% identity in 611 aa overlap). Previously sequenced as O69532|AL023093 (787 aa), Fasta scores: E(): 0, (100.0% identity in 787 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01434 Peptidase_M41, Peptidase family M41. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00674 AAA-protein family signature. Belongs to the AAA family of ATPase and peptidase family M41 (zinc metalloproteases). Cofactor: potentially binds one zinc ion. Q9CD58 No cell wall and cell processes PF00004,PF01434,PF06480 Q9CD58 GO:0007049,GO:0051301,GO:0016021,GO:0004222,GO:0017111,GO:0005886,GO:0006508,GO:0008270,GO:0005524 3.4.24.- Rv3610c Rv3610c AL450380.2 Mycobrowser_v4 CDS 300537 301466 . + 0 ML0229 ML0229 Conserved hypothetical protein ML0229, len: 309 aa. Conserved hypothetical ala-, leu-rich protein, similar to Rv3603c|O06279|AL123456 hypothetical ala-, leu-rich protein from M. tuberculosis (303 aa), Fasta scores: E(): 0, (67.8% identity in 311 aa overlap). Similar to the N-terminal half of Q9X845|AL049630 hypothetical protein SCE126.02C from Streptomyces coelicolor (420 aa), Fasta scores: E(): 4.1e-24, (36.7% identity in 294 aa overlap). Previously sequenced as O69525|AL023093 (309 aa), Fasta scores: E(): 0, (100.0% identity in 309 aa overlap). Q7AQL2 No conserved hypotheticals PF10727,PF10728 Q7AQL2 Rv3603c Rv3603c AL450380.2 Mycobrowser_v4 CDS 365860 366273 . - 0 ML0284c ML0284c Conserved hypothetical protein ML0284c, len: 137 aa. Conserved hypothetical protein, highly similar to Rv0360c|O06310|AL123456 conserved hypothetical protein from M. tuberculosis (145 aa), Fasta scores: E(): 0, (85.4% identity in 137 aa overlap); and similar to Q9X8R4|AL049754 hypothetical protein SCH10.25C from Streptomyces coelicolor (143 aa), Fasta scores: E(): 8.2e-27, (56.2% identity in 130 aa overlap). Previously sequenced as O69598|AL023514 (137 aa), Fasta scores: E(): 0, (100.0% identity in 137 aa overlap). Q7AQK3 No conserved hypotheticals Q7AQK3 Rv0360c Rv0360c AL450380.2 Mycobrowser_v4 CDS 319965 320564 . - 0 ML0244c pth Probable peptidyl-tRNA hydrolase Pth ML0244c, len: 199 aa. Probable pth, peptidyl-tRNA hydrolase (EC 3.1.1.29), highly similar to Rv1014c|PTH_MYCTU|P96386 pth, peptidyl-tRNA hydrolase from M. tuberculosis (191 aa), Fasta scores: E(): 0, (77.7% identity in 188 aa overlap). Similar to many e.g. PTH_ECOLI|P23932 pth, peptidyl-tRNA hydrolase from Escherichia coli (194 aa), Fasta scores: E(): 3.7e-22, (37.2% identity in 188 aa overlap). Contains Pfam match to entry PF01195 Pept_tRNA_hydro, Peptidyl-tRNA hydrolase. Contains PS01196 Peptidyl-tRNA hydrolase signature 2. Belongs to the Pth family. Q9CD49 No intermediary metabolism and respiration PF01195 Q9CD49 GO:0005737,GO:0006412,GO:0004045 3.1.1.29 Rv1014c Rv1014c AL450380.2 Mycobrowser_v4 CDS 321491 321765 . - 0 ML0245A ML0245A hypothetical protein(pseudogene) ML0245A, len:274. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 328067 331741 . + 0 ML0252 mfd Necessary for strand-specific repair. a lesion in the template stand blocks the RNA polymerase complex (RNAp). The RNAp-DNA-RNA complex is specifically recognized by mfd which releases RNAp and the truncated transcript; the mfd may replace RNAp at the lesion site and then recruit the uvrA/B/C repair system. Probable transcription-repair coupling factor Mfd (trcF) ML0252, len: 1224 aa. Probable mfd, transcription-repair coupling factor, highly similar to Rv1020|MFD_MYCTU|P96380 mfd, transcription-repair coupling factor from M. tuberculosis (1234 aa), Fasta scores: E(): 0, (84.3% identity in 1229 aa overlap); and similar to many others e.g. MFD_ECOLI|P30958 mfd, transcription-repair coupling factor from Escherichia coli (1148 aa), Fasta scores: E(): 0, (38.1% identity in 1111 aa overlap). Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. In the N-terminal section; belongs to the uvrB family and in the C-terminal section; belongs to the helicase family. recG subfamily. Q9CD43 No information pathways PF00270,PF00271,PF02559,PF03461 Q9CD43 GO:0008026,GO:0006281,GO:0003684,GO:0006355,GO:0003700,GO:0005524 Rv1020 Rv1020 AL450380.2 Mycobrowser_v4 CDS 320577 321224 . - 0 ML0245c rplY Probable 50S ribosomal protein L25 RplY ML0245c, len: 215 aa. Probable rplY, 50s ribosomal protein L25, highly similar to Rv1015c|RL25_MYCTU|P96385 rplY, 50S ribosomal protein L25 from M. tuberculosis (215 aa), Fasta scores: E(): 0, (73.9% identity in 218 aa overlap). Similar to many others e.g. RL25_ECOLI|P02426 rplY, 50S ribosomal protein L25 from Escherichia coli (94 aa), Fasta scores: E(): 0.00054, (33.7% identity in 89 aa overlap). Contains Pfam match to entry PF01386 Ribosomal_L25p, Ribosomal L25p family. Belongs to the L25P family of ribosomal proteins. Q9CD48 No information pathways Q9CD48 GO:0005840,GO:0003735,GO:0006412,GO:0008097 Rv1015c Rv1015c AL450380.2 Mycobrowser_v4 CDS 335805 336308 . + 0 ML0257 ML0257 Conserved hypothetical protein ML0257, len: 167 aa. Conserved hypothetical protein, highly similar to Rv1025|P96375|AL123456 conserved hypothetical protein from M. tuberculosis (155 aa), Fasta scores: E(): 0, (85.1% identity in 154 aa overlap). Also similar to other hypothetical proteins e.g. Q9F2Q5 conserved hypothetical protein from Streptomyces coelicolor A3(2) (186 aa), Fasta scores: E(): 2e-36, (65.0% identity in 143 aa overlap). Q9CD40 No conserved hypotheticals PF04417 Q9CD40 Rv1025 Rv1025 AL450380.2 Mycobrowser_v4 CDS 336305 337258 . + 0 ML0258 ML0258 Conserved hypothetical protein ML0258, len: 317 aa. Conserved hypothetical protein. Highly similar to Rv1026|P96374|AL123456 conserved hypothetical protein from M. tuberculosis (319 aa), Fasta scores: E(): 0, (77.6% identity in 321 aa overlap). Similar to many bacterial hypothetical proteins and shows weak similarity to N-terminal half of PPX_ECOLI|P29014 ppx, exopolyphosphatase from Escherichia coli (512 aa), Fasta scores: E(): 6.8e-07, (25.3% identity in 297 aa overlap). Also shows weak similarity to ML2434. Q7AQL0 No virulence, detoxification, adaptation PF02541 Q7AQL0 Rv1026 Rv1026 AL450380.2 Mycobrowser_v4 CDS 1337940 1338383 . + 0 ML1147 ML1147 CONSERVED HYPOTHETICAL SECRETED PROTEIN ML1147, len: 147 aa. Conserved hypothetical secreted protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD12_MYCLE (P53432) (147 aa), Fasta scores: E(): 0, 100.0% identity in 147 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1312 TR:YD12_MYCTU. Contains a possible N-terminal signal sequence. P53432 No cell wall and cell processes PF10739 P53432 GO:0016021 Rv1312 Rv1312 AL450380.2 Mycobrowser_v4 CDS 354105 354860 . + 0 ML0270 ML0270 Beta-lactamase-like protein ML0270, len: 251 aa. Beta-lactamase-like protein, highly similar to others from Mycobacteria e.g. Rv0406c|O86336|AL123456 Beta-lactamase-like protein from M. tuberculosis (272 aa), Fasta scores: E(): 0, (74.9% identity in 243 aa overlap); Q9XC16|AF152394 bllP, beta-lactamase-like protein from Mycobacterium avium (247 aa), Fasta scores: E(): 0, (73.7% identity in 243 aa overlap). Shows similarity to other members of the metallo-beta-lactamase superfamily. Previously sequenced as O69590|AL023514 (251 aa), Fasta scores: E(): 0, (100.0% identity in 251 aa overlap). Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Q7AQK7 No conserved hypotheticals PF00753 Q7AQK7 GO:0016787 Rv0406c Rv0406c AL450380.2 Mycobrowser_v4 CDS 354849 355220 . - 0 ML0271c ML0271c Probable conserved transmembrane protein ML0271c, len: 123 aa. Probable conserved transmembrane protein, similar to Rv0401|P95210|AL123456 probable conserved transmembrane protein from M. tuberculosis (123 aa), Fasta scores: E(): 1.9e-32, (66.9% identity in 121 aa overlap). Similar to a region of AAF69175|AC007915 hypothetical protein F27F5.3 from Arabidopsis thaliana (261 aa), Fasta scores: E(): 1.5e-06, (30.8% identity in 120 aa overlap). Previously sequenced as O69591|AL023514 (122 aa), Fasta scores: E(): 0, (100.0% identity in 122 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CCX5 No cell wall and cell processes Q9CCX5 Rv0401 Rv0401 AL450380.2 Mycobrowser_v4 CDS 361297 361953 . - 0 ML0279c ML0279c Conserved hypothetical protein ML0279c, len: 218 aa. Conserved hypothetical protein, highly similar to Rv0356c|O06307|AL123456 conserved hypothetical protein from M. tuberculosis (214 aa), Fasta scores: E(): 0, (73.4% identity in 214 aa overlap); and other bacterial hypothetical proteins. Previously sequenced as O69594|AL023514 (218 aa), Fasta scores: E(): 0, (99.5% identity in 218 aa overlap). Similar to ML0457c a possible pseudogene similar to M. tuberculosis Rv0356c. Q7AQK5 No conserved hypotheticals PF03061 Q7AQK5 Rv0356c Rv0356c AL450380.2 Mycobrowser_v4 CDS 363432 364121 . + 0 ML0281 ML0281 Conserved hypothetical protein ML0281, len: 229 aa. Conserved hypothetical protein, similar to Rv0358|O06308|AL123456 conserved hypothetical protein from M. tuberculosis (215 aa), Fasta scores: E(): 0, (62.4% identity in 229 aa overlap). Previously sequenced as O69596|AL023514 (229 aa), Fasta scores: E(): 0, (99.6% identity in 229 aa overlap). Q7AQK4 No conserved hypotheticals Q7AQK4 Rv0358 Rv0358 AL450380.2 Mycobrowser_v4 CDS 424868 425728 . - 0 ML0335c ML0335c Possible ABC-transporter transmembrane protein ML0335c, len: 286 aa. Possible ABC-transporter transmembrane protein. Similar in part to Rv2060|O86339|AL123456 conserved integral membrane protein from M. tuberculosis (133 aa), Fasta scores: E(): 0, (80.3% identity in 132 aa overlap). Similar, except N-terminal approx. 100 aa to many bacterial ABC transporters e.g. O33704|Z71552 adcB, putative ABC metal permease from Streptococcus pneumoniae (268 aa), Fasta scores: E(): 2.5e-15, (26.6% identity in 263 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00950 ABC-3, ABC 3 transport family. Q9CCW1 No cell wall and cell processes PF00950 Q9CCW1 GO:0042626,GO:0016021,GO:0006810,GO:0005524 AL450380.2 Mycobrowser_v4 CDS 364916 365722 . + 0 ML0283 ML0283 Possible cation-efflux transporter component ML0283, len: 268 aa. Possible cation-efflux transporter component, similar to others e.g. CZCD_ALCEU|P13512 czcD, cobalt-zinc-cadmium resistance protein from Alcaligenes eutrophus (316 aa), Fasta scores: E(): 3.8e-22, (36.4% identity in 209 aa overlap); and Q9X7Q7 putative efflux protein from Streptomyces coelicolor A3(2) (312 aa). Previously sequenced as O69597|AL023514 (256 aa), Fasta scores: E(): 0, (100.0% identity in 256 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Beyond codon 220 (approx.) GC frameplot and codon usage plots indicate a possible frame change. Similarity to characterised transporter components ends at this point. This suggests that the ORF may have suffered a disruption and therefore not encode a functional product. Contains Pfam match to entry PF01545 Cation_efflux, Cation efflux family. Q9CCX3 No cell wall and cell processes PF01545 Q9CCX3 GO:0006812,GO:0016020,GO:0008324 AL450380.2 Mycobrowser_v4 CDS 563633 564538 . + 0 ML0466 ML0466 Possible secreted protein ML0466, len: 301 aa. Possible secreted protein. Similar to Q9X7W9|AL049485|SC6A5.23 hypothetical protein from Streptomyces coelicolor (261 aa), Fasta scores: E(): 9.5e-26, (36.4% identity in 253 aa overlap). Previously sequenced as O07156|Z96801 (301 aa), Fasta scores: E(): 0, (99.7% identity in 301 aa overlap). Contains a possible N-terminal signal sequence. Q7AQI8 No cell wall and cell processes PF00657 Q7AQI8 GO:0006629,GO:0016788 AL450380.2 Mycobrowser_v4 CDS 313910 314698 . + 0 ML0239 tatD Probable deoxyribonuclease TatD ML0239, len: 262 aa. Probable tatD (alternate gene name: yjjV), deoxyribonuclease (EC 3.1.21.-), component of twin arginine translocation protein export system (see citation below for more information). Highly similar to Rv1008|O08343|AL123456 tatD, deoxyribonuclease from M. tuberculosis (264 aa), Fasta scores: E(): 0, (82.3% identity in 260 aa overlap). Similar to members of the TatD family e.g. Bacillus subtilis yabD, conserved hypothetical protein, SW:YABD_BACSU (P37545) (255 aa), Fasta scores: E(): 0, 41.0% identity in 261 aa overlap. Contains Pfam match to entry PF01026 UPF0006, Metalloenzyme of unknown function. Contains PS01137 TatD deoxyribonuclease family signature 1, and PS01091 TatD deoxyribonuclease family signature 3. Q9CD54 No cell wall and cell processes PF01026 Q9CD54 GO:0016888 Rv1008 Rv1008 AL450380.2 Mycobrowser_v4 CDS 382835 383542 . + 0 ML0300 thiE Involved in thiamine biosynthesis. Condenses 4-methy-(beta-hydroxyethyl)-thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [Catalytic activity: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamine monophosphate]. Probable thiamine-phosphate pyrophosphorylase ThiE (TMP pyrophosphorylase) (TMP-PPase) (Thiamine-phosphate synthase). ML0300, len: 235 aa. Probable thiE, thiamin phosphate pyrophosphorylase (EC 2.5.1.3), highly similar to Rv0414c|THIE_MYCTU|P96260 probable thiE, thiamin phosphate pyrophosphorylase from M. tuberculosis (222 aa), Fasta scores: E(): 0, (78.9% identity in 223 aa overlap). Similar to many other e.g. THIE_ECOLI|P30137 thiE, thiamine-phosphate pyrophosphorylase from Escherichia coli (211 aa), Fasta scores: E(): 5e-10, (38.7% identity in 199 aa overlap). Previously sequenced as THIE_MYCLE|Q9ZBL5 (235 aa), Fasta scores: E(): 0, (99.6% identity in 235 aa overlap). Belongs to the TMP-PPase family. Q9ZBL5 No intermediary metabolism and respiration PF02581 Q9ZBL5 GO:0009228,GO:0004789,GO:0000287 2.5.1.3 Rv0414c Rv0414c AL450380.2 Mycobrowser_v4 CDS 489916 490428 . - 0 ML0394c ML0394c Hypothetical protein ML0394c, len: 170 aa. Hypothetical Unknown protein. Possible CDS suggested by GC frameplot and codon usage plots. Some similarity with bacterial methyltransferases e.g. Q98K44 Probable sterol methyltransferase from Mesorhizobium loti (280 aa), Fasta scores: E(): 0, (30.8% identity in 107 aa overlap). Q9CCV0 No unknown Q9CCV0 AL450380.2 Mycobrowser_v4 CDS 589653 589997 . + 0 ML0486 yajC Probable conserved membrane protein secretion factor YajC ML0486, len: 114 aa. Probable yajC, a conserved membrane protein secretion factor, (see Braunstein & Belisle 2000), highly similar to YP88_MYCTU|Q50633|Rv2588c Probable yajC, secretion factor from M. tuberculosis (115 aa), Fasta scores: E(): 7e-29, (77.0% identity in 100 aa overlap); and CAD94804|Mb2619c from M. bovis (115 aa). Similar to other bacterial proteins e.g. Q9L292|SCL2.07c putative secreted protein from Streptomyces coelicolor (169 aa), Fasta scores: E(): 7.3e-08, (35.8% identity in 120 aa overlap). Previously sequenced as YP88_MYCLE|Q49647 (114 aa), Fasta scores: E(): 0, (100.0% identity in 114 aa overlap). Contains a possible N-terminal signal sequence. Q49647 No cell wall and cell processes PF02699 Q49647 GO:0005576 Rv2588c Rv2588c AL450380.2 Mycobrowser_v4 CDS 367279 368316 . - 0 ML0286c fba Probable fructose bisphosphate aldolase Fba ML0286c, len: 345 aa. Probable fba (alternate gene name: fda), fructose bisphosphate aldolase (EC 4.1.2.13), highly similar to Rv0363c|ALF_MYCTU|O06313 fba, fructose bisphosphate aldolase from M. tuberculosis (344 aa), Fasta scores: E(): 0, (87.7% identity in 342 aa overlap). Similar to many e.g. ALF_CORGL|P19537 fructose bisphosphate aldolase from Corynebacterium glutamicum (343 aa), Fasta scores: E(): 0, (72.8% identity in 342 aa overlap). Previously sequenced as ALF_MYCLE|O69600 (345 aa), Fasta scores: E(): 0, (100.0% identity in 345 aa overlap). Contains Pfam match to entry PF01116 F_bP_aldolase, Fructose-bisphosphate aldolase class-II. Contains PS00806 Fructose-bisphosphate aldolase class-II signature 2. Contains PS00602 Fructose-bisphosphate aldolase class-II signature 1. Belongs to class II fructose-bisphosphate aldolase family. Cofactor: zinc. O69600 No intermediary metabolism and respiration PF01116 O69600 GO:0006096,GO:0008270,GO:0004332 4.1.2.13 Rv0363c Rv0363c AL450380.2 Mycobrowser_v4 CDS 77709 82292 . + 0 ML0061 gltB Probable ferredoxin-dependent glutamate synthase (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (NADPH-GOGAT) ML0061, len: 1527 aa. Probable gltB, ferredoxin-dependent glutamate synthase large subunit (EC 1.4.1.13), equivalent to Rv3859c|P96218|Al123456 probable ferredoxin-dependent glutamate synthase from M. tuberculosis (1527 aa), Fasta scores: E(): 0, (90.2% identity in 1527 aa overlap); and similar to other glutamate synthases e.g. GLTB_SYNY3|P55037 gltB, ferredoxin-dependent glutamate synthase 1 from Synechocystis sp. (1550 aa), Fasta scores: E(): 0, (57.2% identity in 1525 aa overlap). Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. Q9CDD5 No intermediary metabolism and respiration PF00310,PF01493,PF01645,PF04898 Q9CDD5 GO:0004355,GO:0055114,GO:0006537 1.4.1.13 Rv3859c Rv3859c AL450380.2 Mycobrowser_v4 CDS 1719817 1720120 . - 0 ML1433B ML1433B putative gluconokinase(pseudogene) ML1433B, len:303. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 296082 296699 . + 0 ML0223 folE Probable GTP cyclohydrolase I FolE (GTP-CH-I) ML0223, len: 205 aa. Probable folE (alternate gene name: gchA), GTP cyclohydrolase I (EC 3.5.4.16), highly similar to Rv3609c|GCH1_MYCTU|O06273 folE, GTP cyclohydrolase I from M. tuberculosis (202 aa), Fasta scores: E(): 0, (82.0% identity in 205 aa overlap). Similar to many others e.g. GCH1_BACSU|P19465 mtrA, GTP cyclohydrolase I from Bacillus subtilis (190 aa), Fasta scores: E(): 0, (59.5% identity in 190 aa overlap). Previously sequenced as GCH1_MYCLE|O69531 (205 aa), Fasta scores: E(): 0, (100.0% identity in 205 aa overlap). Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. Belongs to the GTP cyclohyrolase I family. O69531 No intermediary metabolism and respiration PF01227 O69531 GO:0003934,GO:0005737,GO:0006730,GO:0046654,GO:0008270,GO:0005525 3.5.4.16 Rv3609c Rv3609c AL450380.2 Mycobrowser_v4 CDS 2238736 2238981 . - 0 ML1855c rpmC PROBABLE 50S RIBOSOMAL PROTEIN L29 RPMC ML1855c, len: 81 aa. Probable rpmC, 50S ribosomal protein L29. Similar to M. tuberculosis 50S ribosomal protein L29 Rv0709 SW:RL29_MYCTU (P95057) (77 aa), Fasta scores: E(): 2.5e-25, 91.9% identity in 74 aa overlap. Contains Pfam match to entry PF00831 Ribosomal_L29, Ribosomal L29 protein. O32989 No information pathways PF00831 O32989 GO:0003735,GO:0006412,GO:0005840 Rv0709 Rv0709 AL450380.2 Mycobrowser_v4 CDS 131869 133422 . + 0 ML0102 accD4 Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) ML0102, len: 517 aa. Probable accD4, propyonyl-CoA carboxylase beta chain 4 (EC 6.4.1.3), highly similar to many e.g. Rv3799c|O53578|AL123456 probable accD4, propyonyl-CoA carboxylase from M. tuberculosis (522 aa), Fasta scores: E(): 0, (91.2% identity in 512 aa overlap); and Q9X4K7|AF113605 propionyl-CoA carboxylase complex B subunit from Streptomyces coelicolor (530 aa), Fasta scores: E(): 0, (48.2% identity in 521 aa overlap). Also similar to ML0731 and ML1657 from M. leprae. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. Q9CDB0 No lipid metabolism PF01039 Q9CDB0 GO:0016874 Rv3799c Rv3799c AL450380.2 Mycobrowser_v4 CDS 180027 182150 . + 0 ML0134 fadD22 Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) ML0134, len: 707 aa. Probable fadD22, fatty-acid-CoA synthetase (EC 6.2.1.-). Highly similar to many e.g. Rv2948c|P96283|AL123456 probable fadD22, fatty-acid-CoA synthase from M. tuberculosis (705 aa), Fasta scores: E(): 0, (75.9% identity in 705 aa overlap); and similar to Q59760|L42322 badA, benzoate-coenzyme A ligase from Rhodopseudomonas palustris (521 aa), Fasta scores: E(): 0, (31.4% identity in 494 aa overlap). Also similar to ML1051, ML1994, ML2257 and ML2546 from M. leprae. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Q9CD82 No lipid metabolism PF00501,PF00550 Q9CD82 GO:0003824,GO:0048037,GO:0008152,GO:0000036 Rv2948c Rv2948c AL450380.2 Mycobrowser_v4 CDS 342403 343857 . - 0 ML0262A ML0262A PPE15; PPE family protein(pseudogene) ML0262A, len:1454. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 124599 126506 . + 0 ML0100 fadD32 Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) ML0100, len: 635 aa. Probable fadD32, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to several probable fatty-acid-CoA synthases from M. tuberculosis e.g. Rv3801c|O53580|AL123456 fadD32 (637 aa), Fasta scores: E(): 0, (93.2% identity in 632 aa overlap). Also similar to P71495|U75685 acyl-CoA synthase from Mycobacterium bovis BCG ORF3 (582 aa), Fasta scores: E(): 0, (36.8% identity in 581 aa overlap); and to domains of polyketide synthases e.g. Q50857|U24657 safB, saframycin Mx1 synthetase B from Myxococcus xanthus (1770 aa), Fasta scores: E(): 0, (36.4% identity in 605 aa overlap). And similar to ML0132, ML0138, ML1234 and ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Q9CDB2 No lipid metabolism PF00501 Q9CDB2 GO:0008152,GO:0003824 Rv3801c Rv3801c AL450380.2 Mycobrowser_v4 CDS 2514419 2514589 . - 0 ML2114c ML2114c conserved hypothetical protein ML2114c, len: 56 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 6.4 kda protein Rv0909 TR:O05901 (EMBL:Z95210) fasta scores: E(): 1.8e-07, 61.9% in 42 aa, and to Streptomyces coelicolor hypothetical 9.9 kda protein TR:O69965 (EMBL:AL022268) fasta scores: E(): 0.038, 41.3% in 46 aa. Q9CBE3 No conserved hypotheticals Q9CBE3 Rv0909 Rv0909 AL450380.2 Mycobrowser_v4 CDS 121157 122149 . + 0 ML0097 fbpA Involved in cell wall mycoloylation. Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) ML0097, len: 330 aa. Probable fbpA, precursor of the 85-A antigen (fibronectin-binding protein A) (EC 2.3.1.-) (see citations below), highly similar to Rv3804|A85A_MYCTU|P17944 fbpA, antigen 85-A precursors from M. tuberculosis (338 aa), Fasta scores: E(): 0, (83.0% identity in 329 aa overlap). Also similar to the B- and C- proteins of the mycobacterial antigen 85 complexes. Similar to N-terminal region of CSP1_CORGL|Q01377 PS1 protein precursor from Corynebacterium glutamicum csp1 (657 aa), Fasta scores: E(): 5.2e-31, (38.6% identity in 290 aa overlap). Also similar to ML0098, ML2028 and ML2655 from M. leprae. Previously sequenced as A85A_MYCLE|Q05861 (330 aa), Fasta scores: E(): 0, (100.0% identity in 330 aa overlap). Contains probable N-terminal signal sequence. Contains Pfam match to entry PF00756 Esterase, Putative esterase. Q05861 No lipid metabolism PF00756 Q05861 GO:0005576,GO:0008415 2.3.1.- Rv3804c Rv3804c AL450380.2 Mycobrowser_v4 CDS 2356549 2356902 . - 0 ML1972A ML1972A hypothetical protein(pseudogene) ML1972A, len:353. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-29 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 275049 276008 . + 0 ML0204 galE1 Probable UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) ML0204, len: 319 aa. Probable galE1, UDP-glucose 4-epimerase (EC 5.1.3.2) (see citations below), highly similar to Rv3634c|O06373|AL123456 galE1, UDP-glucose 4-epimerase from M. tuberculosis (314 aa), Fasta scores: E(): 0, (86.1% identity in 309 aa overlap). Similar to other bacterial sugar-nucleotide dehydratases (many putative) e.g. Q9ZGH3|AF079762 desIV, TDP-glucose-4,6-dehydratase from Streptomyces venezuelae (337 aa), Fasta scores: E(): 1.4e-24, (34.3% identity in 321 aa overlap). Previously sequenced as O69544|AL023093 (319 aa), Fasta scores: E(): 0, (100.0% identity in 319 aa overlap). Also similar to ML1964 from M. leprae. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the sugar epimerase family. Note that previously known as rmlB2, a DTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (see third citation). O69544 No intermediary metabolism and respiration PF01370 O69544 GO:0044237,GO:0050662,GO:0003824 Rv3634c Rv3634c AL450380.2 Mycobrowser_v4 CDS 394458 395162 . + 0 ML0308 ML0308 Conserved hypothetical protein ML0308, len: 234 aa. Conserved hypothetical protein, some similarity to hypothetical proteins from methanobacteria e.g. O27829|AE000934 hypothetical protein MTH1801 from Methanobacterium thermoautotrophicum (224 aa), Fasta scores: E(): 3.6e-24, (39.3% identity in 219 aa overlap); and Y045_METJA|Q60353 hypothetical protein MJ0045 from Methanococcus jannaschii (221 aa), Fasta scores: E(): 4e-17, (30.5% identity in 220 aa overlap). Previously sequenced as Q9ZBM1|AL035159 (234 aa), Fasta scores: E(): 0, (100.0% identity in 234 aa overlap). Q7AQJ8 No conserved hypotheticals Q7AQJ8 AL450380.2 Mycobrowser_v4 CDS 268857 270449 . - 0 ML0201c ML0201c Probable conserved transmembrane protein ML0201c, len: 530 aa. Probable conserved transmembrane protein, highly similar to Rv3645|O06362|AL123456 probable transmembrane protein from M. tuberculosis (549 aa), Fasta scores: E(): 0, (85.3% identity in 530 aa overlap); and to several other putative membrane proteins from M. tuberculosis. Shares regions of similarity with adenylate cyclases e.g. P94180|D89622 cyaA, adenylate cyclase from Anabaena sp. (strain PCC 7120) (735 aa), Fasta scores: E(): 1.5e-16, (33.3% identity in 228 aa overlap). Previously sequenced as O69547|AL023093 (530 aa), Fasta scores: E(): 0, (99.8% identity in 530 aa overlap). Also similar to ML1948c a possible pseudogene similar to M. tuberculosis Rv3645. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains 2 Pfam matches to entry PF00211 guanylate_cyc, Adenylate and Guanylate cyclase catalytic domain. Q7AQM3 No cell wall and cell processes PF00211,PF00672 Q7AQM3 GO:0016021,GO:0007242,GO:0016849,GO:0004871,GO:0009190 Rv3645 Rv3645 AL450380.2 Mycobrowser_v4 CDS 5229 7265 . + 0 ML0005 gyrB DNA Gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. This DNA Gyrase is made up of two chains. The A chain is responsible for DNA breakage and rejoining and the B chain catalyzes ATP hydrolysis [Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA]. Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) ML0005, len: 678 aa. Probable gyrB, DNA gyrase subunit B (EC 5.99.1.3) (see citations below). Highly similar to other Mycobacterial DNA GYRASES SUBUNIT B e.g. Rv0005|GYRB_MYCTU|P41514 from M. tuberculosis (686 aa), Fasta scores: E(): 0, (87.5% identity in 678 aa overlap); and GYRB_MYCSM|P48355 from Mycobacterium smegmatis (675 aa), Fasta scores: E(): 0, (85.0% identity in 678 aa overlap). Previously sequenced as GYRB_MYCLE|Q59533 (697 aa), Fasta scores: E(): 0, (100.0% identity in 678 aa overlap). Contains Pfam match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus. Contains Pfam match to entry PF00204 DNA_topoisoII, DNA topoisomerase II (N-terminal region). Contains PS00177 DNA topoisomerase II signature. Belongs to the type II Topoisomerase family. Q59533 No information pathways PF00204,PF00986,PF01751,PF02518 Q59533 GO:0003918,GO:0006265,GO:0005694,GO:0005524 5.99.1.3 Rv0005 Rv0005 AL450380.2 Mycobrowser_v4 CDS 1745023 1745178 . + 0 ML1450B ML1450B hypothetical protein(pseudogene) ML1450B, len:155. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 317042 317977 . + 0 ML0242 ispE Thought to be involved in deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis (at the fourth step). Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. [Catalytic activity: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol]. Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) ML0242, len: 311 aa. Probable ispE, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.-), highly similar to Rv1011|IPK_MYCTU|O05596 ispE, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from M. tuberculosis (306 aa), Fasta scores: E(): 0, (87.5% identity in 303 aa overlap). Similar to many e.g. IPK_ECOLI|P24209 Escherichia coli isopentenyl monophosphate kinase (283 aa), Fasta scores: E(): 1.3e-13, (35.6% identity in 202 aa overlap). Belongs to the IspE family. Q9CD51 No intermediary metabolism and respiration PF00288,PF08544 Q9CD51 GO:0005524,GO:0016310,GO:0016114,GO:0050515 2.7.1.148 Rv1011 Rv1011 AL450380.2 Mycobrowser_v4 CDS 255125 255742 . - 0 ML0190c ML0190c Conserved hypothetical protein ML0190c, len: 205 aa. Conserved hypothetical protein, highly similar to Rv1000c conserved hypothetical protein from M. tuberculosis (205 aa). Also similar to conserved hypothetical proteins in various bacteria e.g. AL357613|AL357613_12 from Streptomyces coelicolor (210 aa), fasta scores: E(): 2.4e-44, (55.1% identity in 205 aa overlap); and AE003963|AE003963_5 from Xylella fastidiosa (200 aa), FASTA scores: E(): 9.7e-14, (39.9% identity in 188 aa overlap). Weak similarity to proteins involved in DNA repair Q9CD62 No conserved hypotheticals Q9CD62 Rv1000c Rv1000c AL450380.2 Mycobrowser_v4 CDS 303740 305263 . + 0 ML0233 lysS Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) ML0233, len: 507 aa. Probable lysS, lysyl-tRNA synthetase 1 (EC 6.1.1.6), highly similar to Rv3598c|SYK_MYCTU|O06284 lysS, probable lysyl-tRNA synthase from M. tuberculosis (505 aa), Fasta scores: E(): 0, (85.4% identity in 501 aa overlap). Similar to many other bacterial lysyl-tRNA synthetases e.g. SYK2_ECOLI|P14825 from Escherichia coli (504 aa), Fasta scores: E(): 0, (38.8% identity in 497 aa overlap). Also similar to the C-terminal half of ML1393 from M. leprae. Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to class-II aminoacyl-tRNA synthetase family. P46861 No information pathways PF00152,PF01336 P46861 GO:0005737,GO:0004824,GO:0006430,GO:0000287,GO:0003676,GO:0005524 6.1.1.6 Rv3598c Rv3598c AL450380.2 Mycobrowser_v4 CDS 166949 167389 . - 0 ML0124c ML0124c Conserved hypothetical protein ML0124c, len: 146 aa. Conserved hypothetical protein, shows weak similarity to Rv2186c|O53519|AL123456 conserved hypothetical protein from M. tuberculosis (129 aa), Fasta scores: E(): 3.7e-06, (27.5% identity in 131 aa overlap); and to Q9X7Y8|AL049497 hypothetical protein SC6G10.02C from Streptomyces coelicolor (144 aa), Fasta scores: E(): 7e-05, (21.9% identity in 137 aa overlap). Also similar to ML2629 and shows weaker similarity to ML0889 from M. leprae. Previously sequenced as O06090|Z95398 (156 aa), Fasta scores: E(): 0, (70.1% identity in 144 aa overlap). Q9CD92 No conserved hypotheticals PF10604 Q9CD92 AL450380.2 Mycobrowser_v4 CDS 517645 518277 . + 0 ML0418 ML0418 Possible oxidoreductase ML0418, len: 210 aa. Possible oxidoreductase (EC 1.-.-.-), highly similar to Rv3368c|O50397|AL123456 possible oxidoreductase from M. tuberculosis (214 aa), Fasta scores: E(): 0, (81.9% identity in 210 aa overlap). Shows weak similarity NOX_THETH|X60110) nox, NADH dehydrogenase from Thermus aquaticus (205 aa), Fasta scores: E(): 0.00023, (28.8% identity in 212 aa overlap); and O30106|AF0131 putative NAD(P)H-flavin oxidoreductase from Archaeoglobus fulgidus (194 aa). Previously sequenced as O07697|Z97179 (210 aa), Fasta scores: E(): 0, (99.5% identity in 210 aa overlap). Also similar to ML2006 a possible pseudogene similar to M. tuberculosis Rv3368c. Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Q7AQJ5 No intermediary metabolism and respiration PF00881 Q7AQJ5 GO:0016491 Rv3368c Rv3368c AL450380.2 Mycobrowser_v4 CDS 248102 249376 . + 0 ML0183 moeA1 Probable molybdopterin biosynthesis protein MoeA1 ML0183, len: 424 aa. Probable moeA1, molybdopterin biosynthesis protein, highly similar to Rv0994|MOEA_MYCTU|O05577 moeA, probable molybdopterin biosynthesis protein from M. tuberculosis (426 aa), Fasta scores: E(): 0, (88.3% identity in 426 aa overlap). Similar to many e.g. MOEA_ECOLI|P12281 moeA, molybdopterin biosynthesis protein from Escherichia coli (411 aa), Fasta scores: E(): 3.3e-23, (31.4% identity in 392 aa overlap). Previously sequenced as Q9Z5G0|AL035500 (424 aa), Fasta scores: E(): 0, (99.8% identity in 424 aa overlap). Contains Pfam match to entry PF00994 MoCF_biosynth, Molybdenum cofactor biosynthesis protein. Note that previously known as moeA. Q9Z5G0 No intermediary metabolism and respiration PF00994,PF03453,PF03454 Q9Z5G0 GO:0006777 Rv0994 Rv0994 AL450380.2 Mycobrowser_v4 CDS 2241944 2242246 . - 0 ML1861c rplW PROBABLE 50S RIBOSOMAL PROTEIN L23 RPLW ML1861c, len: 100 aa. Probable rplW, 50S ribosomal protein L23. Similar to M. tuberculosis 50S ribosomal protein L23 Rv0703 SW:RL23_MYCTU (P95051) (100 aa), Fasta scores: E(): 0, 85.0% identity in 100 aa overlap. Contains Pfam match to entry PF00276 Ribosomal_L23, Ribosomal protein L23. Contains PS00050 Ribosomal protein L23 signature. O32983 No information pathways PF00276 O32983 GO:0019843,GO:0005840,GO:0003735,GO:0006412,GO:0000166 Rv0703 Rv0703 AL450380.2 Mycobrowser_v4 CDS 314948 316075 . + 0 ML0240 rpfB Probable resuscitation-promoting factor RpfB ML0240, len: 375 aa. Probable rpfB, resuscitation-promoting factor (see citation below), highly similar to Rv1009|O05594|AL123456 probable rpfB, resuscitation-promoting factor from M. tuberculosis (362 aa), Fasta scores: E(): 0, (82.3% identity in 361 aa overlap). The C-terminus is similar to a region conserved in many bacterial hypothetical proteins e.g. Q9RKD7|AL132674 hypothetical protein SCE87.01C from Streptomyces coelicolor (330 aa), Fasta scores: E(): 3.2e-14, (33.8% identity in 225 aa overlap). Also similar in part to other M. tuberculosis probable resuscitation-promoting factor e.g. Rv0867c|RPFA, Rv1884c|RPFC, and Rv2389c|RPFD The C-terminus is similar to regions of ML2030 and ML2151. Q9CD53 No cell wall and cell processes PF03990,PF06737,PF07501 Q9CD53 GO:0016787,GO:0005576 Rv1009 Rv1009 AL450380.2 Mycobrowser_v4 CDS 240531 241217 . + 0 ML0174 mprA Mycobacterial persistence regulator MrpA (two-component response transcriptional regulatory protein) ML0174, len: 228 aa. Probable mprA, mycobacterial persistence regulator, a two-component response regulator whose expression is required for entry and maintenance of persistent infections (see citation below), equivalent to Rv0981|O53894|AL123456 mprA, regulator part from a two-component response regulator system from M. tuberculosis (230 aa), Fasta scores: E(): 0, (94.3% identity in 228 aa overlap); and several other putative two-component response regulators e.g. COPR_PSESM|Q02540 copR, transcriptional activator protein involved in activation of copper resistance from Pseudomonas syringae (227 aa), Fasta scores: E(): 6.4e-32, (43.9% identity in 223 aa overlap). Also similar to ML0773, ML1286, ML2123 and ML2439 from M. leprae. Previously sequenced as Q9Z5G8|AL035500 (253 aa), Fasta scores: E(): 0, (100.0% identity in 228 aa overlap). Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain. Q9CD68 No regulatory proteins PF00072,PF00486 Q9CD68 GO:0005737,GO:0009405,GO:0006355,GO:0006950,GO:0006350,GO:0000156,GO:0000160,GO:0003677 Rv0981 Rv0981 AL450380.2 Mycobrowser_v4 CDS 98425 99393 . + 0 ML0078 pheA Possible prephenate dehydratase PheA ML0078, len: 322 aa. Possible pheA, prephenate dehydratase (EC 4.2.1.51) (see citation below), highly similar to Rv3838c|P96240|AL123456 pheA, prephenate dehydratase from M. tuberculosis (321 aa), Fasta scores: E(): 0, (83.9% identity in 311 aa overlap). Similar to PHEA_AMYME|Q44104 pheA, prephenate dehydratase from Amycolatopsis methanolica (304 aa), Fasta scores: E(): 0, (44.4% identity in 315 aa overlap). Contains Pfam match to entry PF01842 ACT, ACT domain. Contains Pfam match to entry PF00800 PDT, Prephenate dehydratase. Contains PS00858 Prephenate dehydratase signature 2. Q9CDC4 No intermediary metabolism and respiration PF00800,PF01842 Q9CDC4 GO:0016597,GO:0004664,GO:0009094 4.2.1.51 Rv3838c Rv3838c AL450380.2 Mycobrowser_v4 CDS 2375712 2376425 . - 0 ML1988c ML1988c PROBABLE CONSERVED MEMBRANE PROTEIN ML1988c, len: 237 aa. Probable conserved membrane protein. Similar to M. tuberculosis probable membrane protein Rv0093c SW:Y093_MYCTU (Q10890) E():0 70.3% identity in 236 aa. Contains possible membrane spanning hydrophobic domains. Note lacks the N-terminal 46 aa of the M. tuberculosis protein. Q9CBG8 No cell wall and cell processes Q9CBG8 Rv0093c Rv0093c AL450380.2 Mycobrowser_v4 CDS 19001 20869 . - 0 ML0016c pknB Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) ML0016c, len: 622 aa. Probable pknB, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to Rv0014c|PKNB_MYCTU|P71584 pknB, transmembrane serine/threonine protein kinase from M. tuberculosis (626 aa), Fasta scores: E(): 0, (86.3% identity in 626 aa overlap); and similar to Q9ZFS8|AF094711 pksC, serine/threonine protein kinase from Streptomyces coelicolor (556 aa), Fasta scores: E(): 0, (47.8% identity in 297 aa overlap). Also similar to ML0017 and ML0897 and to part of ML0304 from M. leprae. Previously sequenced as PKNB_MYCLE|P54744 (622 aa), Fasta scores: E(): 0, (99.7% identity in 622 aa overlap). Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains PS00107 Protein kinases ATP-binding region signature. P54744 No regulatory proteins PF00069,PF03793 P54744 GO:0000287,GO:0008658,GO:0006468,GO:0004674,GO:0005524 2.7.11.1 Rv0014c Rv0014c AL450380.2 Mycobrowser_v4 CDS 223972 224619 . + 0 ML0160 purN Probable 5'-phosphoribosylglycinamide formyltransferase PurN (garT) (gar transformylase) (5'-phosphoribosylglycinamide transformylase) ML0160, len: 215 aa. Probable purN, 5'-phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), highly similar to Rv0956|P71554|AL123456 purN, 5'-phosphoribosylglycinamide formyltransferase from M. tuberculosis (215 aa), Fasta scores: E(): 0, (79.4% identity in 214 aa overlap). Similar to many e.g. TQ9RAJ6|AF191543 purN, phosphoribosylglycinamide formyltransferase I from Mycobacterium avium subsp. paratuberculosis (209 aa), Fasta scores: E(): 0, (81.6% identity in 207 aa overlap). Previously sequenced as Q9Z5H6|AL035500 (215 aa), Fasta scores: E(): 0, (99.5% identity in 215 aa overlap). Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase. Q9Z5H6 No intermediary metabolism and respiration PF00551 Q9Z5H6 GO:0009058,GO:0004644,GO:0006189 Rv0956 Rv0956 AL450380.2 Mycobrowser_v4 CDS 152783 153613 . - 0 ML0112c rfbD Probable lipopolysaccharide transport integral membrane ABC transporter RfbD ML0112c, len: 276 aa. Probable rfbD, polysaccharide-transport integral membrane protein ABC transporter (see first citation below), involved in O-antigen/lipopolysaccharides (LPS) transport, highly similar to Rv3783|P72049|AL123456 rfbD, polysaccharide-transport integral membrane protein ABC transporter from M. tuberculosis (280 aa) Fasta scores: E(): 0, (84.3% identity in 280 aa overlap). Similar to RFBD_YEREN|Z18920 rfbD, O-antigen export system permease protein from Yersinia enterocolitica (259 aa)(see second citation below), Fasta scores: E(): 2.9e-32, (28.2% identity in 259 aa overlap); and to other membrane proteins involved in lipopolysaccharide transport. Contains Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter. Belongs to the ABC-2 subfamily of integral membrane proteins. Q9CDA2 No cell wall and cell processes PF01061 Q9CDA2 GO:0016020 Rv3783 Rv3783 AL450380.2 Mycobrowser_v4 CDS 102122 103375 . + 0 ML0082 serS Probable seryl-tRNA synthetase SerS (serine--tRNA ligase) (SERRS) (serine translase) ML0082, len: 417 aa. Probable serS, seryl-tRNA synthetase (EC 6.1.1.11), highly similar to Rv3834c|SYS_MYCTU|P96244 serS, seryl-tRNA synthetase from M. tuberculosis (419 aa), Fasta scores: E(): 0, (85.8% identity in 416 aa overlap). Similar to SYS_STAAU|Y09924 serS, seryl-tRNA synthetase from Staphylococcus aureus (428 aa), Fasta scores: E(): 0, (36.8% identity in 418 aa overlap). Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to the class-II aminoacyl-tRNA synthetase family. Q9CDC1 No information pathways PF00587,PF02403 Q9CDC1 GO:0005737,GO:0016260,GO:0004828,GO:0006434,GO:0005524 6.1.1.11 Rv3834c Rv3834c AL450380.2 Mycobrowser_v4 CDS 219659 220561 . + 0 ML0156 sucD Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) ML0156, len: 300 aa. Probable sucD, succinyl-CoA synthetase, alpha chain (EC 6.2.1.5), highly similar to Rv0952|SUCD_MYCTU|P71558 sucD, succinyl-CoA synthetase, alpha chain from M. tuberculosis (303 aa), Fasta scores: E(): 0, (86.3% identity in 300 aa overlap). Similar to many e.g. SUCD_ECOLI|P07459 sucD, succinyl-CoA synthase, alpha chain from Escherichia coli (288 aa), Fasta scores: E(): 0, (50.3% identity in 298 aa overlap). Previously sequenced as Q9S372|AL035500 (300 aa), Fasta scores: E(): 0, (100.0% identity in 300 aa overlap). Contains Pfam match to entry PF00549 ligase-CoA, CoA-ligases. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. Contains PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. Q9S372 No intermediary metabolism and respiration PF00549,PF02629 Q9S372 GO:0005488,GO:0008152,GO:0004775,GO:0003878 6.2.1.5 Rv0952 Rv0952 AL450380.2 Mycobrowser_v4 CDS 379127 379966 . + 0 ML0295 thiD Probable phosphomethylpyrimidine kinase ThiD ML0295, len: 279 aa. Probable thiD, phosphomethylpyrimidine kinase (EC 2.7.4.7), highly similar to Rv0422c|THID_MYCTU|P96268 thiD, phosphomethylpyrimidine kinase from M. tuberculosis (265 aa), Fasta scores: E(): 0, (77.8% identity in 266 aa overlap). Similar to many others e.g. THID_ECOLI|P76422 thiD, phosphomethylpyrimidine kinase from Escherichia coli (266 aa), Fasta scores: E(): 3.2e-29, (38.4% identity in 263 aa overlap). Previously sequenced as THID_MYCLE|Q9ZBL1 (279 aa), Fasta scores: E(): 0, (99.6% identity in 279 aa overlap). Belongs to the ThiD family. Q9ZBL1 No intermediary metabolism and respiration PF08543 Q9ZBL1 GO:0008972,GO:0009228,GO:0005524 2.7.4.7 Rv0422c Rv0422c AL450380.2 Mycobrowser_v4 CDS 2414171 2414238 . - 0 ML2022A ML2022A hypothetical protein(pseudogene) ML2022A, len:67. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.005 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 381655 382677 . - 0 ML0299c thiO Possible thiamine biosynthesis oxidoreductase ThiO ML0299c, len: 340 aa. Possible thiO, thiamine biosynthesis oxidoreductase (EC 1.-.-.-), highly similar to Rv0415|P96261|AL123456 possible thiO, thiamine biosynthesis oxidoreductase from M. tuberculosis (340 aa), Fasta scores: E(): 0, (82.0% identity in 338 aa overlap). Shows weak similarity to GLOX_BACSU|O31616 goxB, glycine oxidase from Bacillus subtilis (369 aa), Fasta scores: E(): 6.6e-10, (28.7% identity in 352 aa overlap). Previously sequenced as Q9ZBL4|AL035159 (340 aa), Fasta scores: E(): 0, (100.0% identity in 340 aa overlap). Also shows weak similarity to ML2011 from M. leprae. Contains Pfam match to entry PF01266 DAO, D-amino acid oxidase. Q7AQJ9 No intermediary metabolism and respiration PF01266 Q7AQJ9 GO:0008152,GO:0016491,GO:0050660 Rv0415 Rv0415 AL450380.2 Mycobrowser_v4 CDS 400772 401779 . - 0 ML0314c lipU Possible lipase LipU ML0314c, len: 335 aa. Possible lipU, lipase (EC 3.1.-.-), highly similar to Rv1076|O53424|AL123456 lipU, possible lipase from M. tuberculosis (297 aa), Fasta scores: E(): 0, (79.7% identity in 296 aa overlap); and to other putative lipases and esterases from M. tuberculosis. Also similar to other bacterial lipases and esterases e.g. BAH_STRHY|Q01109 bah, acetyl-hydrolase from Streptomyces hygroscopicus (299 aa), Fasta scores: E(): 6.6e-19, (36.2% identity in 246 aa overlap). Previuosly sequenced as Q9ZBM4|AL035159 (335 aa), Fasta scores: E(): 0, (99.7% identity in 335 aa overlap). Contains PS01174 Lipolytic enzymes 'G-D-X-G' family, putative serine active site. Q7AQJ7 No intermediary metabolism and respiration PF07859 Q7AQJ7 GO:0008152,GO:0016787 Rv1076 Rv1076 AL450380.2 Mycobrowser_v4 CDS 403699 404613 . - 0 ML0315c ML0315c Probable oxidoreductase ML0315c, len: 304 aa. Probable oxidoreductase (EC 1.-.-.-), highly similar to Rv0068|O53613|AL123456 probable oxidoreductase from M. tuberculosis (303 aa), Fasta scores: E(): 0, (73.9% identity in 306 aa overlap); and to other M. tuberculosis putative oxidoreductases e.g. Rv0439c (311 aa). Similar to many bacterial putative oxidoreductases e.g. CAB69779|AL137187 putative oxidoreductase SC7A8.30C from Streptomyces coelicolor (310 aa), Fasta scores: E(): 0, (47.9% identity in 311 aa overlap). Previously sequenced as Q9ZBM5|AL035159 (304 aa), Fasta scores: E(): 0, (100.0% identity in 304 aa overlap). Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Q7AQJ6 No intermediary metabolism and respiration PF00106 Q7AQJ6 GO:0008152,GO:0016491,GO:0005488 Rv0068 Rv0068 AL450380.2 Mycobrowser_v4 CDS 404708 405310 . + 0 ML0316 ML0316 Possible transcriptional regulator (TetR family) ML0316, len: 200 aa. Possible TetR/AcrR-family transcriptional regulator, highly similar except in N-terminus to Rv0067c|O53612|AL123456 possible transcriptional regulator from M. tuberculosis (189 aa), Fasta scores: E(): 0, (68.8% identity in 189 aa overlap). Similar to many putative transcriptional regulators e.g. Q9RJL5|AL121849 putative tetR family transcriptional regulator SCF6.16 from Streptomyces coelicolor (194 aa), Fasta scores: E(): 2.5e-18, (39.5% identity in 185 aa overlap). Previously sequenced as Q9ZBM6|AL035159 (189 aa), Fasta scores: E(): 0, (100.0% identity in 189 aa overlap). Contains a probable helix-turn-helix motif at aa 45-66 (Score 1800, SD +5.32). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Belongs to the tetR/acrR family of transcriptional regulators. Q9CCW8 No regulatory proteins PF00440 Q9CCW8 GO:0003700,GO:0006355 Rv0067c Rv0067c AL450380.2 Mycobrowser_v4 CDS 413628 414464 . + 0 ML0324 ML0324 Possible tRNA/rRNA methyltransferase ML0324, len: 278 aa. Possible tRNA/rRNA methyltransferase (EC 2.1.1.-), highly similar (longer 31 aa) to Rv3579c|P96861|AL123456 possible tRNA/rRNA methyltransferase from M. tuberculosis (322 aa), Fasta scores: E(): 0, (84.1% identity in 277 aa overlap). Similar to many hypothetical rRNA methyltransferases e.g. Q9L0Q5 putative tRNA/rRNA methyltransferase from Streptomyces coelicolor A3(2) (314 aa), Fasta scores: E(): 0, (54.5% identity in 288 aa overlap). Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family. Q9CCW4 No intermediary metabolism and respiration PF00588,PF08032 Q9CCW4 GO:0008173,GO:0006396,GO:0003723 Rv3579c Rv3579c AL450380.2 Mycobrowser_v4 CDS 438263 439315 . + 0 ML0348 ML0348 Possible coenzyme F420-dependent oxidoreductase ML0348, len: 350 aa. Possible coenzyme F420-dependent oxidoreductase (EC 1.-.-.-), highly similar to Rv3520c|O53565|AL123456 possible coenzyme F420-dependent oxidoreductase from M. tuberculosis (347 aa), Fasta scores: E(): 0, (86.8% identity in 342 aa overlap). Similar to other coenzyme F420-dependent enzymes (and other proteins) e.g. Q50744|X86477 mer, methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (321 aa), Fasta scores: E(): 2.8e-05, (27.1% identity in 332 aa overlap); and Q9AD98|SCI52.11c putative ATP/GTP-binding protein from Streptomyces coelicolor (351 aa). Q9CCV8 No intermediary metabolism and respiration PF00296 Q9CCV8 GO:0016491,GO:0055114 Rv3520c Rv3520c AL450380.2 Mycobrowser_v4 CDS 476441 477286 . + 0 ML0383 ML0383 Conserved hypothetical protein ML0383, len: 281 aa. Conserved hypothetical protein, highly similar to Rv3415c|Q50711|AL123456 conserved hypothetical protein from M. tuberculosis (275 aa), Fasta scores: E(): 0, (73.6% identity in 277 aa overlap). Previously sequenced as Q49858|U00020 (264 aa), Fasta scores: E(): 0, (99.6% identity in 263 aa overlap). Q9CCV3 No conserved hypotheticals Q9CCV3 Rv3415c Rv3415c AL450380.2 Mycobrowser_v4 CDS 486264 488642 . - 0 ML0392c ML0392c Possible hydrolase ML0392c, len: 792 aa. Possible hydrolase (EC 3.-.-.-), highly similar to Rv3401|YY01_MYCTU|Q50724 conserved hypothetical protein from M. tuberculosis (786 aa), Fasta scores: E(): 0, (91.4% identity in 782 aa overlap). Similar to other bacterial hydrolases and transferases e.g. Q9L2I8|SCF42.31c putative glycosyl transferase from Streptomyces coelicolor (792 aa), Fasta scores: E(): 0, (58.9% identity in 790 aa overlap); and Q9K109|NMB0390 maltose phosphorylase from Neisseria meningitidis (serogroup B) (752 aa). Previously sequenced as YY01_MYCLE|Q49736 (792 aa), Fasta scores: E(): 0, (100.0% identity in 792 aa overlap). Contains a probable helix-turn-helix motif at aa 515-536 (Score 1032, SD +2.70). Contains Pfam match entry to PF03632; Glyco_hydro_65m, PF03633; Glyco_hydro_65c and PF03636; Glyco_hydro_65n. Belongs to family 65 of glycosyl hydrolases. Q49736 No intermediary metabolism and respiration PF03632,PF03633,PF03636 Q49736 GO:0005975,GO:0016798,GO:0030246 3.2.1.- Rv3401 Rv3401 AL450380.2 Mycobrowser_v4 CDS 1270160 1270768 . - 0 ML1099c lprE PROBABLE LIPOPROTEIN LPRE ML1099c, len: 202 aa. Probable lprE lipoprotein. Highly similar to Mycobacterium tuberculosis putative lipoprotein SW:LPRE_MYCTU (Q11065) (202 aa), Fasta scores: E(): 0, 71.3% identity in 202 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CC94 No cell wall and cell processes Q9CC94 GO:0005886 Rv1252c Rv1252c AL450380.2 Mycobrowser_v4 CDS 564584 565228 . + 0 ML0467 dedA Possible transmembrane protein DedA ML0467, len: 214 aa. Possible dedA, transmembrane protein, highly similar to Rv2637|YQ37_MYCTU|P71936 dedA, dedA-family protein from M. tuberculosis (218 aa), Fasta scores: E(): 0, (82.8% identity in 209 aa overlap). Similar to many dedA-family hypothetical proteins e.g. P09548|DEDA_ECOLI|B2317|Z3579|ECS3201 dedA protein (DSG-1 PROTEIN) from Escherichia coli strains K12 and O157:H7 (219 aa). Previously sequenced as YQ37_MYCLE|Q49642 (214 aa), Fasta scores: E(): 0, (100.0% identity in 214 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00597 DedA, DedA family. Belongs to the dedA family. Q49642 No cell wall and cell processes PF09335 Q49642 GO:0005886,GO:0016021 Rv2637 Rv2637 AL450380.2 Mycobrowser_v4 CDS 488656 489441 . - 0 ML0393c ML0393c Probable hydrolase ML0393c, len: 261 aa. Probable hydrolase (EC 3.-.-.-), highly similar to Rv3400|YY00_MYCTU|Q50725 probable hydrolase from M. tuberculosis (262 aa), Fasta scores: E(): 0, (74.4% identity in 262 aa overlap). Similar to several various proteins (notably hydrolases) e.g. Q9L2I7|SCF42.32 PUTATIVE HYDROLASE from Streptomyces coelicolor (246 aa), FASTA scores: opt: 843, E(): 7.6e-47, (51.61% identity in 248 aa overlap); and Q9I5X4|PA0562 PROBABLE HYDROLASE from Pseudomonas aeruginosa (224 aa). Previously sequenced as YY00_MYCLE|Q49741 (261 aa), Fasta scores: E(): 0, (100.0% identity in 261 aa overlap). Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. Q49741 No intermediary metabolism and respiration PF00702 Q49741 GO:0008152,GO:0003824 Rv3400 Rv3400 AL450380.2 Mycobrowser_v4 CDS 518415 518891 . - 0 ML0419c spoU Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) ML0419c, len: 158 aa. Probable spoU, tRNA/rRNA methylase (EC 2.1.1.-), highly similar to Rv3366|O50394|AL123456 spoU, possible RNA methyltransferase from M. tuberculosis (154 aa), Fasta scores: E(): 0, (83.8% identity in 154 aa overlap). Also similar to many members of the spoU family of rRNA methylases e.g. TRMH_ECOLI|P19396 spoU, tRNA (guanosine-2'-o-)-methyltransferase from Escherichia coli (229 aa), Fasta scores: E(): 4e-05, (30.4% identity in 148 aa overlap); and Q9K199|NMB0268 RNA methyltransferase (TRMH family) from Neisseria meningitidis (serogroup B) (154 aa). Previously sequenced as O07698|Z97179 (169 aa), Fasta scores: E(): 0, (100.0% identity in 158 aa overlap). Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family. Belongs to the RNA methyltransferase TRMH family. Q9CCU7 No information pathways PF00588 Q9CCU7 GO:0008173,GO:0006396,GO:0003723 Rv3366 Rv3366 AL450380.2 Mycobrowser_v4 CDS 524417 524644 . + 0 ML0425 ML0425 Possible conserved membrane protein ML0425, len: 75 aa. Possible conserved membrane protein, similar to Rv2520c|O53225|AL123456 possible conserved membrane protein from M. tuberculosis (75 aa), Fasta scores: E(): 2.2e-15, (57.3% identity in 75 aa overlap). Previously sequenced as O07706|Z97179) (91 aa), Fasta scores: E(): 7.9e-29, (100.0% identity in 75 aa overlap). Contains hydrophobic, possible membrane-spanning region. Q9CCU6 No cell wall and cell processes Q9CCU6 Rv2520c Rv2520c AL450380.2 Mycobrowser_v4 CDS 526295 526942 . - 0 ML0427c orn Probable oligoribonuclease Orn ML0427c, len: 215 aa. Probable orn, oligoribonuclease (EC 3.1.-.-), highly similar to Rv2511|ORN_MYCTU|O06174 orn, probable oligoribonuclease from M. tuberculosis (215 aa), Fasta scores: E(): 0, (84.5% identity in 213 aa overlap). Similar to many others e.g. ORN_ECOLI|P39287 orn, oligoribonuclease from Escherichia coli (180 aa), Fasta scores: E(): 8.2e-25, (45.3% identity in 172 aa overlap). Previously sequenced as ORN_MYCLE|O07708 (215 aa), Fasta scores: E(): 0, (99.5% identity in 215 aa overlap). O07708 No intermediary metabolism and respiration PF00929 O07708 GO:0016896,GO:0003676,GO:0005737 3.1.-.- Rv2511 Rv2511 AL450380.2 Mycobrowser_v4 CDS 530917 531696 . - 0 ML0431c ML0431c Possible conserved proline rich membrane protein ML0431c, len: 259 aa. Possible conserved pro-rich membrane protein, highly Similar to Rv2507|O06170|AL123456 membrane protein from M. tuberculosis (273 aa), Fasta scores: E(): 0, (60.4% identity in 275 aa overlap). Previously sequenced as O07711|Z97179 (261 aa), Fasta scores: E(): 0, (100.0% identity in 259 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CCU3 No cell wall and cell processes Q9CCU3 Rv2507 Rv2507 AL450380.2 Mycobrowser_v4 CDS 566058 566840 . - 0 ML0468c ML0468c Possible conserved intergal membrane protein ML0468c, len: 260 aa. Possible conserved intergal membrane protein, similar to other bacterial membrane and hypothetical protein e.g. Q9ADJ7|SCBAC14E8.02C putative integral membrane protein from Streptomyces coelicolor (255 aa), Fasta scores: E(): 1.4e-35, (49.2% identity in 255 aa overlap); and Q9YFR6|AP000058|APE0183 hypothetical protein from Aeropyrum pernix (270 aa), Fasta scores: E(): 7.2e-07, (26.2% identity in 256 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q49657 No cell wall and cell processes PF01925 Q49657 GO:0016021 AL450380.2 Mycobrowser_v4 CDS 632968 633531 . + 0 ML0522 efp INVOLVED IN PEPTIDE BOND SYNTHESIS. STIMULATE EFFICIENT TRANSLATION AND PEPTIDE-BOND SYNTHESIS ON NATIVE OR RECONSTITUTED 70S RIBOSOMES IN VITRO. PROBABLY FUNCTIONS INDIRECTLY BY ALTERING THE AFFINITY OF THE RIBOSOME FOR AMINOACYL-TRNA, THUS INCREASING THEIR REACTIVITY AS ACCEPTORS FOR PEPTIDYL TRANSFERASE. Probable elongation factor P Efp ML0522, len: 187 aa. Probable efp, elongation factor P, highly similar to EFP_MYCTU|P95019|Rv2534c efp, elongation factor P from M. tuberculosis (187 aa), Fasta scores: E(): 2.8e-76, (94.1% identity in 186 aa overlap); and CAD94748|Mb2563c from M. bovis (187 aa). Similar to many e.g. Q45288|EFP_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (187 aa), FASTA scores: E(): 6.3e-55, (69.892% identity in 186 aa overlap). Contains Pfam match to entry PF01132 EFP, Elongation factor P (EF-P). Contains PS01275 Elongation factor P signature. Belongs to the elongation factor P family. Q9CCS0 No information pathways PF01132,PF08207,PF09285 Q9CCS0 GO:0003746,GO:0006414,GO:0005737 Rv2534c Rv2534c AL450380.2 Mycobrowser_v4 CDS 1746224 1746877 . - 0 ML1451D ML1451D hypothetical protein(pseudogene) ML1451D, len:653. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = e-108 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2365062 2365142 . - 0 ML1980A ML1980A tpx; thiol peroxidase(pseudogene) ML1980A, len:80. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 593295 594962 . + 0 ML0489 ML0489 Possible conserved lipoprotein ML0489, len: 555 aa. Possible conserved lipoprotein precursor, possibly attached to the membrane by a lipid anchor and substrate-binding protein involved in transport, highly similar to YP85_MYCTU|Q50636|Rv2585c Possible conserved lipoprotein precursor from M. tuberculosis (557 aa), Fasta scores: E(): 4.7e-164, (78.9% identity in 546 aa overlap); and CAD94801|Mb2616c from M. bovis (557 aa). Also similar in part to various proteins, principally substrate-binding proteins, e.g. O87329|DCIAE DIPEPTIDE-BINDING PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (502 aa), FASTA scores: E(): 4.4e-26, (29.224% identity in 438 aa overlap); Q8U840 ABC transporter, substrate binding protein from Agrobacterium tumefaciens (strain C58/ATCC 33970) (553 aa), fasta scores: E(): 2.5e-05, (24.726% identity in 457 aa overlap). Previously sequenced as YP85_MYCLE|Q49646 (426 aa), Fasta scores: E(): 0, (98.8% identity in 332 aa overlap). Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q49646 No cell wall and cell processes PF00496 Q49646 GO:0006810,GO:0005215,GO:0005886 Rv2585c Rv2585c AL450380.2 Mycobrowser_v4 CDS 617502 618443 . + 0 ML0508 ML0508 Conserved hypothetical protein ML0508, len: 313 aa. Conserved hypothetical protein, highly similar to YP69_MYCTU|Q50652|Rv2569c conserved hypothetical protein from M. tuberculosis (314 aa), Fasta scores: E(): 0, (84.4% identity in 301 aa overlap); and CAD94784|Mb2599c from M. bovis (314 aa). And similar to other hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas aeruginosa (311 aa), FASTA scores: E(): 1.3e-35, (36.774% identity in 310 aa overlap). Also similar to ML0607 and Rv2409c from M. tuberculosis. Contains Pfam match to entry PF01841 Transglut_core, Transglutaminase-like superfamily. Q9CCT2 No conserved hypotheticals PF01841,PF08379 Q9CCT2 Rv2569c Rv2569c AL450380.2 Mycobrowser_v4 CDS 599081 599737 . + 0 ML0493 ML0493 Possible glyoxalase II (Hydroxyacylglutathione hydrolase) (GLX II) ML0493, len: 218 aa. Possible glyoxalase II (EC 3.1.2.6), highly similar to YP81_MYCTU|Q50640|Rv2581c Possible glyoxalase II from M. tuberculosis (224 aa), Fasta scores: E(): 1.1e-82, (82.0% identity in 222 aa overlap); and CAD94797|Mb2612c from M. bovis (224 aa). Also similar to Q9KXP1|SC9C5.33c Possible hydrolase from Streptomyces coelicolor (235 aa), FASTA scores: E(): 5.4e-38, (47.945% identity in 219 aa overlap); and AAP11173 Hydroxyacylglutathione hydrolase from Bacillus cereus (strain ATCC 14579 / DSM 31) (209 aa), fasta scores: E(): 4.3e-25, (39.048% identity in 210 aa overlap). Also similar to ML1391 and ML1912. Previously sequenced as YP81_MYCLE|Q49649 (218 aa), Fasta scores: E(): 0, (99.5% identity in 218 aa overlap). Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Belongs to the glyoxalase II family. Cofactor: Binds two Zinc ions. Q49649 No virulence, detoxification, adaptation PF00753 Q49649 GO:0008270,GO:0016787 3.-.-.- Rv2581c Rv2581c AL450380.2 Mycobrowser_v4 CDS 629569 630654 . + 0 ML0518 aroB 3-dehydroquinate synthase AroB ML0518, len: 361 aa. aroB, 3-dehydroquinate synthase (EC 4.6.1.3), highly similar to AROB_MYCTU|P36919|Rv2538c aroB, 3-dehydroquinate synthase from M. tuberculosis (362 aa), Fasta scores: E(): 0, (87.3% identity in 361 aa overlap); and CAD94752|Mb2567c from M. bovis (362 aa). Also highly similar to many e.g. Q9KXQ6|AROB_STRCO from Streptomyces coelicolor (363 aa), FASTA scores: E(): 2.1e-77, (58.146% identity in 356 aa overlap). Contains Pfam match to entry PF01761 DHQ_synthase, 3-dehydroquinate synthase. Q9CCS4 No intermediary metabolism and respiration PF01761 Q9CCS4 GO:0009073,GO:0005737,GO:0003856 4.2.3.4 Rv2538c Rv2538c AL450380.2 Mycobrowser_v4 CDS 628973 629572 . + 0 ML0517 aroK Shikimate kinase AroK (SK) ML0517, len: 199 aa. aroK, shikimate kinase (EC 2.7.1.71), highly similar to AROK_MYCTU|P95014|Rv2539c aroK, shikimate kinase from M. tuberculosis (176 aa), Fasta scores: E(): 0, (79.6% identity in 167 aa overlap); and CAD94753|Mb2568c from M. bovis (176 aa). Similar to many e.g. AROK_ECOLI|P24167 aroK, shikimate kinase I from Escherichia coli (172 aa), Fasta scores: E(): 3.5e-13, (38.0% identity in 166 aa overlap). Contains Pfam match to entry PF01202 SKI, Shikimate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS01128 Shikimate kinase signature. Belongs to the Shikimate kinase family. Q9CCS5 No intermediary metabolism and respiration PF01202 Q9CCS5 GO:0009073,GO:0005737,GO:0000287,GO:0004765,GO:0005524 2.7.1.71 Rv2539c Rv2539c AL450380.2 Mycobrowser_v4 CDS 625434 626699 . + 0 ML0514 ML0514 Probable conserved membrane protein ML0514, len: 421 aa. Probable conserved membrane protein, highly similar to P95000|AL123456|Rv2553c Conserved membrane protein from M. tuberculosis (417 aa), Fasta scores: E(): 1.1e-123, (72.7% identity in 414 aa overlap); and CAD94768|Mb2583c from M. bovis (417 aa). C-terminal half is similar to e.g. Q9L9G6|AF170880 novB, gene from novobiocin biosynthetic gene cluster from Streptomyces sphaeroides (284 aa), Fasta scores: E(): 2.5e-22, (40.0% identity in 210 aa overlap). Shows full-length similarity to other hypothetical proteins e.g. Q9EWY3|2SCG38.36 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (253 aa), FASTA scores: E(): 1.1e-20, (38.835% identity in 206 aa overlap). Contains hydrophobic, possible membrane-spanning region near the N-terminus. Q9CCS8 No cell wall and cell processes PF02618 Q9CCS8 Rv2553c Rv2553c AL450380.2 Mycobrowser_v4 CDS 646544 647836 . + 0 ML0533 pyrC Probable dihydroorotase PyrC (DHOase) ML0533, len: 430 aa. Probable pyrC, dihydroorotase (EC 3.5.2.3), highly similar to P71809|AL123456|Rv1381 probable pyrC, dihydroorotase from M. tuberculosis (430 aa), Fasta scores: E(): 0, (88.8% identity in 427 aa overlap); and CAD94277|Mb1416 from M. bovis (430 aa). Similar to many e.g. PYRC_BACCL|P46538 pyrC, dihydroorotase from Bacillus caldolyticus (427 aa), Fasta scores: E(): 4.1e-52, (40.0% identity in 407 aa overlap). Contains Pfam match to entry PF00744 Dihydrooratase, Dihydroorotase-like. Belongs to the DHOase family. Subfamily 2. Cofactor: Binds 2 zinc ion per subunit. Q9CCR4 No intermediary metabolism and respiration PF01979 Q9CCR4 GO:0006221,GO:0008270,GO:0004151 3.5.2.3 Rv1381 Rv1381 AL450380.2 Mycobrowser_v4 CDS 817110 818258 . - 0 ML0682c metA Probable homoserine o-acetyltransferase MetA ML0682c, len: 382 aa. Probable metA, homoserine o-acetyltransferase (EC 2.3.1.31), highly similar to O53391|AL123456|Rv3341 metA, homoserine o-acetyltransferase from M. tuberculosis (379 aa), Fasta scores: E(): 0, (85.0% identity in 380 aa overlap); and CAD95499|Mb3373 from M. bovis (379 aa). Similar to many e.g. Q8FRT0|METX_COREF Homoserine O-acetyltransferase from Corynebacterium efficiens (388 aa), fasta scores: E(): 2.9e-65, (49.086% identity in 383 aa overlap). Previously sequenced as O32874|Z98271 (382 aa), Fasta scores: E(): 0, (100.0% identity in 382 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. BELONGS TO THE AB HYDROLASE FAMILY, HTA SUBFAMILY. O32874 No intermediary metabolism and respiration PF00561 O32874 GO:0004414,GO:0009086,GO:0005737 2.3.1.31 Rv3341 Rv3341 AL450380.2 Mycobrowser_v4 CDS 697159 697944 . + 0 ML0572 tpi Probable triosephosphate isomerase Tpi (TIM) ML0572, len: 261 aa. Probable tpi, Triosephosphate isomerase (EC 5.3.1.1), highly similar to TPIS_MYCTU|O08408|Rv1438 tpi, triosephosphate isomerase from M. tuberculosis (261 aa), Fasta scores: E(): 0, (83.9% identity in 261 aa overlap). Similar to many e.g. TPIS_CORGL|P19583 tpi, triosephosphate isomerase from Corynebacterium glutamicum (259 aa), Fasta scores: E(): 0, (64.5% identity in 256 aa overlap). Previously sequenced as TPIS_MYCLE|P46711 (261 aa), Fasta scores: E(): 0, (99.6% identity in 261 aa overlap). Contains Pfam match to entry PF00121 TIM, Triosephosphate isomerase. Contains PS00171 Triosephosphate isomerase active site. Belongs to the Triosephosphate isomerase family. P46711 No intermediary metabolism and respiration PF00121 P46711 GO:0006094,GO:0006096,GO:0006098,GO:0004807,GO:0005737 5.3.1.1 Rv1438 Rv1438 AL450380.2 Mycobrowser_v4 CDS 738235 739212 . + 0 ML0606 ML0606 Conserved hypothetical protein ML0606, len: 325 aa. Conserved hypothetical protein, highly similar to P71733|AL123456|Rv2410c conserved hypothetical protein from M. tuberculosis (325 aa), Fasta scores: E(): 0, (90.8% identity in 325 aa overlap); and CAD97294|Mb2433c from M. bovis (325 aa). Similar to other bacterial hypothetical proteins. This CDS and the upstream CDS are also similar to the C- and N-terminal regions respectively, of the longer hypothetical proteins from M. tuberculosis and M. leprae e.g. Rv2567|YP67_MYCTU from M. tuberculosis (884 aa); and ML2679 from M. leprae (894 aa). Previously sequenced as Q49770|U00016 (325 aa), Fasta scores: E(): 0, (100.0% identity in 325 aa overlap). Q49770 No conserved hypotheticals PF04168 Q49770 Rv2410c Rv2410c AL450380.2 Mycobrowser_v4 CDS 703243 703986 . - 0 ML0579c devB Probable 6-phosphogluconolactonase DevB (6PGL) ML0579c, len: 247 aa. Possible devB (pgl), 6-phosphogluconolactonase (EC 3.1.1.31), highly similar to 6PGL_MYCTU|O06814|Rv1445c devB, 6-phosphogluconolactonase from M. tuberculosis (247 aa), Fasta scores: E(): 0, (72.8% identity in 246 aa overlap); and CAD96147|Mb1480c from M. bovis (247 aa). Similar to many e.g. Q9XAB7|6PGL_STRCO 6-phosphogluconolactonase from Streptomyces coelicolor (261 aa), fasta scores: E(): 5.5e-45, (51.639% identity in 244 aa overlap). Previously sequenced as 6PGL_MYCLE|Q49700 (247 aa), Fasta scores: E(): 0, (99.6% identity in 247 aa overlap). Contains Pfam match to entry PF01182 Glucosamine_iso, Glucosamine-6-phosphate isomerase. Belongs to the Glucosamine/Galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. Q49700 No intermediary metabolism and respiration PF01182 Q49700 GO:0006098,GO:0017057 3.1.1.31 Rv1445c Rv1445c AL450380.2 Mycobrowser_v4 CDS 706462 707589 . - 0 ML0582c tal Probable transaldolase Tal ML0582c, len: 375 aa. Probable tal, Transaldolase (EC 2.2.1.2), highly similar to TAL_MYCTU|O06812|Rv1448c tal, transaldolase from M. tuberculosis (373 aa), Fasta scores: E(): 7.9e-120, (78.9% identity in 370 aa overlap); and CAD96150|Mb1483c from M. bovis (373 aa). Highly similar to many e.g. O88018|TAL1_STRCO Transaldolase 1 from Streptomyces coelicolor (381 aa), fasta scores: E(): 2e-85, (61.983% identity in 363 aa overlap). Previously sequenced as TAL_MYCLE|P55193 (375 aa), Fasta scores: E(): 0, (100.0% identity in 375 aa overlap). Contains Pfam match to entry PF00923 Transaldolase, Transaldolase. Contains PS01054 Transaldolase signature 1. Contains PS00958 Transaldolase active site. Belongs to the Transaldolase family. P55193 No intermediary metabolism and respiration PF00923 P55193 GO:0006098,GO:0004801,GO:0005737 2.2.1.2 Rv1448c Rv1448c AL450380.2 Mycobrowser_v4 CDS 2394357 2394449 . + 0 ML2001A ML2001A hypothetical protein(pseudogene) ML2001A, len:92. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 717873 718637 . + 0 ML0592 ML0592 Probable transcriptional regulatory protein ML0592, len: 254 aa. Probable transcriptional regulatory protein, highly similar to O53151|AL123456|Rv1460 Probable transcriptional regulatory protein from M. tuberculosis (268 aa), Fasta scores: E(): 0, (79.6% identity in 250 aa overlap); and CAD96162|Mb1495 from M. bovis (268 aa). Similar to other bacterial transcriptional regulatory and hypothetical proteins e.g. Q8NQ74 Predicted transcriptional regulator from Corynebacterium glutamicum (Brevibacterium flavum) (231 aa), fasta scores: E(): 2.3e-36, (49.302% identity in 215 aa overlap); and Q9XAD0|AL096839|SCC22.08C putative DNA-binding protein from Streptomyces coelicolor (252 aa), Fasta scores: E(): 5.6e-30, (45.4% identity in 216 aa overlap). Previously sequenced as Q49688|U00013 (254 aa), Fasta scores: E(): 0, (99.6% identity in 254 aa overlap). Contains a probable helix-turn-helix motif at aa 215-236 (Score 1054, SD +2.78) Q7AQH6 No regulatory proteins PF01022 Q7AQH6 GO:0006355,GO:0003700,GO:0005622 Rv1460 Rv1460 AL450380.2 Mycobrowser_v4 CDS 724980 725327 . + 0 ML0598 ML0598 Conserved hypothetical protein ML0598, len: 115 aa. Conserved hypothetical protein, highly similar to O53157|AL123456|Rv1466 conserved hypothetical protein from M. tuberculosis (115 aa), Fasta scores: E(): 0, (82.6% identity in 115 aa overlap); and CAD96168|Mb1501 from M. bovis (656 aa). Similar to several hypothetical proteins and hypothetical proteins located downstream of sigma factors in Streptococcus mutans and Streptococcus pneumoniae e.g. O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa). Previously sequenced as Q49691|U00013 (115 aa), Fasta scores: E(): 0, (100.0% identity in 115 aa overlap). Contains Pfam match to entry PF01883 DUF59, Domain of unknown function. Q7AQH3 No conserved hypotheticals PF01883 Q7AQH3 Rv1466 Rv1466 AL450380.2 Mycobrowser_v4 CDS 756771 757802 . + 0 ML0624 hrcA Probable heat-inducible transcription repressor HrcA ML0624, len: 343 aa. Probable hrcA, heat-inducible transcriptional repressor (see citation below), highly similar to HRCA_MYCTU|O05824|Rv2374c hrcA, heat-inducible transcription repressor from M. tuberculosis (343 aa), Fasta scores: E(): 1.2e-116, (89.5% identity in 343 aa overlap); and CAD97256|Mb2395c from M. bovis (343 aa). Similar to many e.g. HRCA_BACST|Q45550 hcrA, heat-inducible transcription repressor from Bacillus stearothermophilus (344 aa), Fasta scores: E(): 3.5e-26, (28.3% identity in 336 aa overlap). Previously sequenced as Q49749|U00016 (197 aa), Fasta scores: E(): 0, (99.5% identity in 196 aa overlap). Contains Pfam match to entry PF01628 HrcA, HrcA protein. Belongs to the HrcA family. Q9CCN2 No virulence, detoxification, adaptation PF01628 Q9CCN2 GO:0006950,GO:0006350,GO:0016564,GO:0045892 Rv2374c Rv2374c AL450380.2 Mycobrowser_v4 CDS 761195 761731 . + 0 ML0628 ML0628 Conserved hypothetical protein ML0628, len: 178 aa. Conserved hypothetical protein, highly similar to YN67_MYCTU|O05831|Rv2367c Conserved hypothetical protein from M. tuberculosis (182 aa), Fasta scores: E(): 5.9e-67, (89.1% identity in 175 aa overlap); and CAD97249|Mb2388c from M. bovis (182 aa). Similar to many bacterial hypothetical proteins e.g. Q9L2L4|YP33_STRCO|AL136534|SCC117.06 hypothetical protein from Streptomyces coelicolor (165 aa), Fasta scores: E(): 1e-31, (54.5% identity in 154 aa overlap). Similar to O51806|AF000954 dgk, diacyglycerol kinase from Streptococcus mutans (164 aa), Fasta scores: E(): 3.8e-07, (30.9% identity in 162 aa overlap). Previously sequenced as YN67_MYCLE|Q49752 (178 aa), Fasta scores: E(): 0, (100.0% identity in 178 aa overlap). Contains Pfam match to entry PF02130 UPF0054, Uncharacterized protein family UPF0054. Contains PS01306 Uncharacterized protein family UPF0054 signature. Q49752 No conserved hypotheticals PF02130 Q49752 GO:0008270,GO:0008237 3.4.24.- Rv2367c Rv2367c AL450380.2 Mycobrowser_v4 CDS 380273 380475 . - 0 ML0296A ML0296A hypothetical protein(pseudogene) ML0296A, len:202. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-14 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 763033 763359 . + 0 ML0630 ML0630 Conserved hypothetical protein ML0630, len: 108 aa. Conserved hypothetical protein, highly similar to O05833|AL123456|Rv2365c Conserved hypothetical protein from M. tuberculosis (113 aa), Fasta scores: E(): 1.5e-22, (67.9% identity in 106 aa overlap); and CAD97247|Mb2386c (113 aa) from M. bovis. Similar to Q9RDF3|AL136503|SCC77.05 Hypothetical protein from Streptomyces coelicolor (132 aa), Fasta scores: E(): 3.3e-06, (39.4% identity in 99 aa overlap). Previously sequenced as Q49767|U00016 (108 aa), Fasta scores: E(): 0, (100.0% identity in 108 aa overlap). Q49767 No conserved hypotheticals Q49767 Rv2365c Rv2365c AL450380.2 Mycobrowser_v4 CDS 774507 775946 . - 0 ML0642c ML0642c Conserved hypothetical protein ML0642c, len: 479 aa. Conserved hypothetical protein, highly similar to O53341|AL123456|Rv3195 conserved hypothetical protein from M. tuberculosis (472 aa), Fasta scores: E(): 0, (79.2% identity in 475 aa overlap) and CAD95309|Mb3217 from M. bovis (472 aa). Similar to several hypothetical proteins e.g. Q9FCI9|SCO5199 Hypothetical protein from Streptomyces coelicolor (487 aa), Fasta scores: opt: 1341, E(): 3e-76, (44.856% identity in 486 aa overlap). Previously sequenced as Q49746|U00016 (479 aa), Fasta scores: E(): 0, (99.8% identity in 479 aa overlap). Q49746 No conserved hypotheticals PF10103 Q49746 Rv3195 Rv3195 AL450380.2 Mycobrowser_v4 CDS 1055263 1055670 . + 0 ML0888 ML0888 conserved hypothetical protein ML0888, len: 135 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv2186c|O53520|AL021957 (129 aa), Fasta scores: E(): 0, 80.0% identity in 130 aa overlap. Previously sequenced as Mycobacterium leprae hypothetical protein TR:O69576 (EMBL:AL022602) (135 aa), Fasta scores: E(): 0, 100.0% identity in 135 aa overlap. Q7AQE1 No conserved hypotheticals Q7AQE1 Rv2186c Rv2186c AL450380.2 Mycobrowser_v4 CDS 2761260 2761610 . - 0 ML2330c ML2330c conserved hypothetical protein ML2330c, len: 116 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis hypothetical protein Rv3716c TR:O69683 (EMBL:AL022121) (133 aa) fasta scores: E(): 4e-27, 83.7% identity in 104 aa, and Escherichia coli hypothetical 12.0 kDa protein SW:YBAB_ECOLI (P17577; P09994) (109 aa) fasta scores: E(): 9.7e-08, 35.0% identity in 100 aa. Note the N-terminus is rich in the amino acid Gln. O69519 No conserved hypotheticals PF02575 O69519 Rv3716c Rv3716c AL450380.2 Mycobrowser_v4 CDS 776009 777031 . + 0 ML0643 ML0643 Possible conserved secreted protein ML0643, len: 340 aa. Possible conserved secreted protein, highly similar to O53340|AL123456|Rv3194c conserved hypothetical protein from M. tuberculosis (340 aa), Fasta scores: E(): 0, (80.3% identity in 340 aa overlap); and CAD95308|Mb3216c from M. bovis (340 aa). Similar to other bacterial hypothetical and putative secreted protein e.g. Q8NS96 Predicted secreted protein containing a PDZ domain from Corynebacterium glutamicum (Brevibacterium flavum) (350 aa), fasta scores: opt: 912, E(): 9.5e-49, (42.571% identity in 350 aa overlap); and Q9S3Y5|AF170560 sdrC, hypothetical protein from Streptomyces coelicolor (241 aa), Fasta scores: E(): 5.5e-18, (34.9% identity in 318 aa overlap). Contains a possible N-terminal signal sequence. Q9CCM7 No cell wall and cell processes Q9CCM7 GO:0005515 Rv3194c Rv3194c AL450380.2 Mycobrowser_v4 CDS 771723 771992 . + 0 ML0639 whiB7 Probable transcriptional regulatory protein WhiB7 ML0639, len: 89 aa. Probable whiB7, WhiB-like regulatory protein, highly similar to Rv3197A whiB7, WhiB-like regulatory protein from M. tuberculosis (92 aa), fasta scores: opt: 441, E(): 1.5e-26, (69.318% identity in 88 aa overlap); and CAD95313|Mb3221c from M. bovis (92 aa). Shows similarity to members of the whiB-family of transcriptional regulators e.g. Q8GHG1 WhiB7 from Streptomyces coelicolor A3(2) (122 aa), fasta scores: opt: 316, E(): 9.6e-17, (56.522% identity in 69 aa overlap). Also similar to ML0382, ML0760, ML0804 and ML2307 from M. leprae. Previously sequenced as Q49765|U00016 (89 aa), Fasta scores: E(): 0, (100.0% identity in 89 aa overlap). Contains a match to Pfam entry PF02467; Whib. Q49765 No regulatory proteins PF02467 Q49765 Rv3197A Rv3197A AL450380.2 Mycobrowser_v4 CDS 1061011 1061526 . + 0 ML0895 ML0895 conserved hypothetical protein ML0895, len: 171 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69570 (EMBL:AL022602) (171 aa), Fasta scores: E(): 0, 100.0% identity in 171 aa overlap and highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53513 (EMBL:AL021957) (168 aa), Fasta scores: E(): 0, 83.1% identity in 166 aa overlap. Q7AQD5 No conserved hypotheticals Q7AQD5 Rv2179c Rv2179c AL450380.2 Mycobrowser_v4 CDS 797293 798690 . - 0 ML0661c fadE24 Probable acyl-CoA dehydrogenase FadE24 ML0661c, len: 465 aa. Probable fadE24, acyl-CoA dehydrogenase (1.3.99.-), highly similar to P95187|AL123456|Rv3139 fadE24, acyl-CoA dehydrogenase from M. tuberculosis (468 aa), Fasta scores: E(): 2e-163, (83.6% identity in 464 aa overlap); and CAD95255|Mb3163 from M. bovis (468 aa). Similar to many e.g. Q9HUH0 Probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (429 aa), fasta scores: opt: 1116, E(): 5.2e-66, (44.836% identity in 426 aa overlap). Also similar to ML0737. Previously sequenced as O32890|Z98271 (465 aa), Fasta scores: E(): 0, (100.0% identity in 465 aa overlap) .Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2. O32890 No lipid metabolism PF00441,PF02770,PF02771 O32890 GO:0003995,GO:0009055,GO:0008152,GO:0050660 Rv3139 Rv3139 AL450380.2 Mycobrowser_v4 CDS 805921 806610 . + 0 ML0669 ftsE Putative cell division ATP-binding protein FtsE (SEPTATION COMPONENT-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER) ML0669, len: 229 aa. Putative ftsE, cell division protein, septation component transport ATP-binding protein ABC transporter, highly similar to O05779|AL123456|Rv3102c ftsE, cell division protein, septation component transport ATP-binding protein ABC transporter from M. tuberculosis (229 aa), Fasta scores: E(): 0, (91.7% identity in 229 aa overlap); and CAD96816|Mb3129c from M. bovis (229 aa). Similar to many e.g. FTSE_ECOLI|P10115 ftsE, cell division ATP-binding protein from Escherichia coli (222 aa), Fasta scores: E(): 0, (49.1% identity in 216 aa overlap). Previously sequenced as O32883|Z98271 (229 aa), Fasta scores: E(): 0, (100.0% identity in 229 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). O32883 No cell wall and cell processes PF00005 O32883 GO:0016887,GO:0051301,GO:0005524 Rv3102c Rv3102c AL450380.2 Mycobrowser_v4 CDS 798767 799534 . - 0 ML0662c ML0662c Probable monophosphatase ML0662c, len: 255 aa. Probable monophosphatase (EC 3.1.3.-), highly similar to P95189|AL123456|Rv3137 Probable monophosphatase from M. tuberculosis (260 aa), Fasta scores: E(): 0, (81.8% identity in 253 aa overlap); and CAD95253|Mb3161 from M. bovis (260 aa). Similar to several e.g. Q9K4B1 Putative monophosphatase from Streptomyces coelicolor (266 aa), fasta scores: opt: 955, E(): 3.7e-56, (56.746% identity in 252 aa overlap). Also similar to ML1024. Previously sequenced as O32889|Z98271 (255 aa), Fasta scores: E(): 0, (100.0% identity in 255 aa overlap). Contains 2 Pfam matches to entry PF00459 inositol_P, Inositol monophosphatase family. Contains PS00629 Inositol monophosphatase family signature 1. Q7AQG7 No intermediary metabolism and respiration PF00459 Q7AQG7 GO:0004437 Rv3137 Rv3137 AL450380.2 Mycobrowser_v4 CDS 998975 999898 . + 0 ML0841 mmp1 major membrane protein I Mmp1 ML0841, len: 307 aa. mmp1, Major membrane protein 1. Highly similar to Q9RAJ4|AJ250887 Mycobacterium paratuberculosis 35 kDa protein (307 aa), fasta scores: E(): 0, 92.2% identity in 307 aa and to MMP1_MYCAV|Q48899 Mycobacterium avium major membrane protein I mmpI (307 aa), fasta scores: E(): 0, 89.6% identity in 308 aa. Previously sequenced as P46841. ML0841 encodes a dominant antigen (see Winter et al., 1995). P46841 No cell wall and cell processes P46841 GO:0016020,GO:0005829 AL450380.2 Mycobrowser_v4 CDS 807507 807989 . + 0 ML0671 smpB Probable SsrA-binding protein SmpB ML0671, len: 160 aa. Probable smpB, SsrA-binding protein, highly similar to SMPB_MYCTU|P96294|Rv3100c smpB, SsrA-binding protein from M. tuberculosis (160 aa), Fasta scores: E(): 0, (84.9% identity in 159 aa overlap); and CAD96814|Mb3127c from M. bovis (160 aa). Similar to many e.g. SMPB_ECOLI|P32052 smpB, SSRA-binding protein essential for the peptide-tagging activity of SsrA (tmRNA) from Escherichia coli (159 aa), Fasta scores: E(): 4.1e-19, (41.8% identity in 146 aa overlap). Previously sequenced as SMPB_MYCLE|O32881 (160 aa), Fasta scores: E(): 0, (99.4% identity in 160 aa overlap). Contains Pfam match to entry PF01668 SmpB, SmpB protein. Contains PS01317 Protein smpB signature. BELONGS TO THE SSRP FAMILY. O32881 No virulence, detoxification, adaptation PF01668 O32881 GO:0005737,GO:0006412,GO:0003723 Rv3100c Rv3100c AL450380.2 Mycobrowser_v4 CDS 435450 435566 . - 0 ML0344A ML0344A hypothetical protein(pseudogene) ML0344A, len:116. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 840883 842154 . - 0 ML0703c ML0703c Conserved hypothetical protein ML0703c, len: 423 aa. Conserved hypothetical protein, highly similar to O53362|AL123456|Rv3311 conserved hypothetical protein from M. tuberculosis (420 aa), Fasta scores: E(): 0, (77.5% identity in 423 aa overlap); and CAD95431|Mb3339 from M. bovis (420 aa). Weakly similar to Q8NSJ0 Hypothetical protein Cgl0681 from Corynebacterium glutamicum (Brevibacterium flavum) (409 aa), fasta scores: E(): 3.1e-26, (31.579% identity in 418 aa overlap). Q9CCL8 No conserved hypotheticals Q9CCL8 Rv3311 Rv3311 AL450380.2 Mycobrowser_v4 CDS 836442 836933 . - 0 ML0698c sdhD Probable succinate dehydrogenase (hydrophobic membrane anchor protein) SdhD (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) ML0698c, len: 163 aa. Probable sdhD, membrane anchor of succinate dehydrogenase SdhD subunit (EC 1.3.99.1), highly similar to O53369|AL123456|Rv3317 sdhD, putative membrane anchor of succinate dehydrogenase from M. tuberculosis (144 aa), Fasta scores: E(): 0, (85.2% identity in 142 aa overlap); and CAD95438|Mb3346 from M. bovis (144 aa). Similar to several e.g. Q9KZ89 Putative succinate dehydrogenase membrane subunit from Streptomyces coelicolor (160 aa), fasta scores: E(): 1.6e-29, (50.968% identity in 155 aa overlap). Previously sequenced as Q49915|U00022 (163 aa), Fasta scores: E(): 0, (100.0% identity in 163 aa overlap). Contains hydrophobic, possible membrane-spanning regions. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. Q49915 No intermediary metabolism and respiration Q49915 Rv3317 Rv3317 AL450380.2 Mycobrowser_v4 CDS 871758 872012 . - 0 ML0730c ML0730c Conserved hypothetical protein ML0730c, len: 84 aa. Conserved hypothetical protein, similar to Rv3281|MTCY71.21|P96886|Z92771 Conserved hypothetical protein from Mycobacterium tuberculosis (177 aa) fasta scores: E(): 2.4e-22, (69.0% identity in 87 aa); and CAD95401|Mb3309 from M. bovis (156 aa). Previously sequenced as Q49671|U00012. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. Q7AQF7 No conserved hypotheticals, lipid metabolism Q7AQF7 Rv3281 Rv3281 AL450380.2 Mycobrowser_v4 CDS 870029 870919 . - 0 ML0728c sseA Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) ML0728c, len: 296 aa. Probable sseA, thiosulfate sulfurtransferase (EC 2.8.1.1), highly similar to THT2_MYCTU|P96888|Rv3283 sseA, thiosulfate sulfurtransferase from M. tuberculosis (297 aa), Fasta scores: E(): 5.4e-110, (83.4% identity in 296 aa overlap); and CAD95403|Mb3311 from M. bovis (297 aa). Similar to many e.g. P71121|THTR_CORGL Thiosulfate sulfurtransferase from Corynebacterium glutamicum (Brevibacterium flavum) (301 aa), fasta scores: E(): 1.5e-73, (58.276% identity in 290 aa overlap). Also similar to ML2198 from M. leprae and Rv3117 from M. tuberculosis. Previously sequenced as THT2_MYCLE|P46700 (296 aa), Fasta scores: E(): 0, (99.7% identity in 296 aa overlap). Contains 2 Pfam matches to entry PF00581 Rhodanese, Rhodanese-like domain. Contains PS00380 Rhodanese signature 1. Contains PS00683 Rhodanese C-terminal signature. BELONGS TO THE RHODANESE FAMILY. In M. tuberculosis sseA is thought to be differentially expressed within host cells (see Triccas et al., 1999). P46700 No intermediary metabolism and respiration PF00581 P46700 GO:0004792,GO:0008272 2.8.1.1 Rv3283 Rv3283 AL450380.2 Mycobrowser_v4 CDS 874678 875196 . + 0 ML0733 ML0733 Probable conserved transmembrane protein ML0733, len: 172 aa. Probable conserved transmembrane protein, highly similar to Rv3278c|MTCY71.18c|P96883|Z92771 conserved transmembrane protein from Mycobacterium tuberculosis (172 aa), fasta scores: E(): 0, (83.1% identity in 172 aa); and CAD95398| from M. bovis (172 aa). Previously sequenced as Q49672|U00012. Contains hydrophobic, possible membrane-spanning regions. Q9CCL2 No cell wall and cell processes PF03703 Q9CCL2 Rv3278c Rv3278c AL450380.2 Mycobrowser_v4 CDS 1042386 1043024 . + 0 ML0878 ML0878 Probable conserved transmembrane protein ML0878, len: 212 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis transmembrane protein Rv2197c|MTCY190.08C|YL97_MYCTU|Q10389 (214 aa) fasta scores: E(): 0, 62.6% identity in 211 aa and Rv0008c|MTCY10H4.07c|Y008_MYCTU|P71577 from M. tuberculosis (214 aa) fasta scores: E(): 0, 62.6% identity in 211 aa. Contains several membrane spanning regions. Q9CCE8 No cell wall and cell processes Q9CCE8 Rv2197c Rv2197c AL450380.2 Mycobrowser_v4 CDS 875151 875837 . - 0 ML0734c ML0734c Probable conserved transmembrane protein ML0734c, len: 228 aa. Probable conserved transmembrane protein, highly similar to Rv3277|MTCY71.17|P96882|Z92771 Probable conserved transmembrane protein from Mycobacterium tuberculosis hypothetical (272 aa), fasta scores: E(): 4e-84, (84.6% identity in 228 aa); and CAD95397|Mb3305 from M. bovis (272 aa). Also similar to other membrane proteins e.g. Q82DA6 Putative integral membrane protein from Streptomyces avermitilis (162 aa), fasta scores: E(): 1.2e-08, (35.075% identity in 134 aa overlap). Previously sequenced as Q49673|U00012. Contains hydrophobic, possible membrane-spanning regions. Q7AQF6 No cell wall and cell processes PF04138 Q7AQF6 GO:0000271,GO:0006810,GO:0016021 Rv3277 Rv3277 AL450380.2 Mycobrowser_v4 CDS 890982 891260 . - 0 ML0748c ML0748c conserved hypothetical protein ML0748c, len: 92 aa. Conserved hypothetical protein, highly similar to Rv3269|MTCY71.09|P96874|Z92771 Conserved hypothetical protein from M. tuberculosis (93 aa) fasta scores: E(): 5.5e-23, (73.6% identity in 91 aa), CAD95389| from M. bovis (93 aa). Similar to many Mycobacterium proteins and chaperonins/heat shock proteins e.g. Rv1993c|MTCY39.26|YJ93_MYCTU|Q10865 hypothetical protein from M. tuberculosis (90 aa), fasta scores: E(): 6.3e-14, (60.8% identity in 79 aa) and Rv0968|MTCY10D7.06c|Y968_MYCTU|P71542 hypothetical protein from M. tuberculosis (98 aa), fasta scores:E(): 4.4e-11, (52.1% identity in 96 aa). Q9CCL0 No virulence, detoxification, adaptation PF07371 Q9CCL0 Rv3269 Rv3269 AL450380.2 Mycobrowser_v4 CDS 893622 894557 . + 0 ML0751 rmlD dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-RHAMNOSE MODIFICATION PROTEIN) (dTDP-RHAMNOSE BIOSYNTHESIS PROTEIN) (dTDP-RHAMNOSE SYNTHASE) ML0751, len: 311 aa. Probable rmlD, dTDP-6-deoxy-L-lyxo-4-hexulose reductase (dTDP-rhamnose modification protein) (EC 1.-.-.-) (see citations below), highly similar to Rv3266c|MTCY71.06c|P96871|Z92771 rmlD, dTDP-6-deoxy-L-lyxo-4-hexulose reductase from Mycobacterium tuberculosis (304 aa), fasta scores: E(): 0, (74.4% identity in 312 aa); and CAD95386|Mb3294c from M. bovis (304 aa). Similar to several dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) e.g. P29781|STRL_STRGR dTDP-4-dehydrorhamnose reductase from Streptomyces griseus (304 aa), fasta scores: E(): 1.4e-32, (44.409% identity in 313 aa overlap). Q9CCK8 No intermediary metabolism and respiration PF04321 Q9CCK8 GO:0008831,GO:0045226,GO:0005488 Rv3266c Rv3266c AL450380.2 Mycobrowser_v4 CDS 936848 937606 . + 0 ML0793 ML0793 conserved hypothetical protein ML0793, len: 252 aa. Conserved hypothetical protein, highly similar to Rv3226c|MTCY20B11.01c|O05872|Z95121 Conserved hypothetical protein from M. tuberculosis (252 aa), fasta scores: E(): 7.5e-76, (70.6% identity in 252 aa); and CAD95347| from M. bovis (252 aa). Similar to various hypothetical bacterial proteins e.g. O64131|AF020713 yoqW protein from Bacteriophage SPBc2 (224 aa), fasta scores: E(): 4.8e-21, (36.5% identity in 244 aa). Q9CCI2 No conserved hypotheticals PF02586 Q9CCI2 Rv3226c Rv3226c AL450380.2 Mycobrowser_v4 CDS 942267 942443 . + 0 ML0796 ML0796 conserved hypothetical protein ML0796, len: 58 aa. Conserved hypothetical protein, similar to the N-termini of Rv0844c|MTV043.37c|O53856|AL022004 Possible narL, nitrate/nitrite response regulator protein from Mycobacterium tuberculosis(216 aa), fasta scores: E(): 0.2, (39.7% identity in 63 aa); and Q53894|U51332|SCE8.19 absA2 from Streptomyces coelicolor (222 aa), fasta scores: E(): 4.3, (38.5% identity in 52 aa). This truncated CDS is possibly a pseudogene. Q7AQF5 No conserved hypotheticals Q7AQF5 AL450380.2 Mycobrowser_v4 CDS 445850 446608 . + 0 ML0352A ML0352A hypothetical protein(pseudogene) ML0352A, len:758. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-27 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 470765 471844 . + 0 ML0378 ML0378 probable acetyltransferase ML0378, len: 359 aa. Probable acetyltransferase (EC 2.3.1.-). ML0378 appears to be a fusion of two M. tuberculosis homologues. In the C-terminus it is very similar to Rv3420c|Q50708|Z77165 rimI, probable ribosomal protein S18 acetyltransferase (158 aa), Fasta scores: E(): 0, (72.1% identity in 154 aa overlap); and in the N-terminus to Rv3421c|YY21_MYCTU|Q50707 conserved hypothetical protein (211 aa), Fasta scores: E(): 0, (75.6% identity in 205 aa overlap). Also similar to some other bacterial acetyltransferases and hypothetical proteins. Previously sequenced as YY21_MYCLE|Q49857 (359 aa), Fasta scores: E(): 0, (100.0% identity in 359 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. Q49857 No intermediary metabolism and respiration, information pathways, conserved hypotheticals PF00583,PF00814 Q49857 GO:0006474,GO:0004222,GO:0006508,GO:0008080 Rv3420c,Rv3421c Rv3420c,Rv3421c AL450380.2 Mycobrowser_v4 CDS 963596 963844 . + 0 ML0814 ML0814 conserved hypothetical protein TB9.4 homolog ML0814, len: 82 aa. Conserved hypothetical protein, similar to M.tuberculosis Rv3208A (90 aa), and similar to Streptomyces coelicolor hypothetical protein. FASTA scores: Rv3208A, E(): 3e-32, 82% identity in 82 aa; AL390975|AL390975_32 Streptomyces coelicolor (94 aa) E(): 2.5e-09; 47.945 % identity in 73 aa overlap. Q9CCH1 No conserved hypotheticals Q9CCH1 Rv3208A Rv3208A AL450380.2 Mycobrowser_v4 CDS 584382 587948 . - 0 ML0484c fadD9 Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) ML0484c, len: 1188 aa. Probable fadD9, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to Q50631|Al123456|Rv2590 fadD9, probable fatty-acid-CoA synthetase from M. tuberculosis (1168 aa), fasta scores: E(): 0, (68.0% identity in 1178 aa overlap). Similar to other long chain fatty acid ligases and to domains of polyketide/peptide synthetases e.g. Q10896|Rv0101|MTCY251.20|NRP Probable peptide synthetase from Mycobacterium tuberculosis (2512 aa), FASTA scores: E(): 1.8e-116, (41.313% identity in 1036 aa overlap); Q9RLP6|AJ238027 mps, peptide synthetase from Mycobacterium smegmatis (5990 aa), fasta scores: E(): 4.6e-99, (37.2% identity in 1168 aa overlap). Previously sequenced as O69484|AL023591 (1174 aa), Fasta scores: E(): 0, (100.0% identity in 1174 aa overlap). Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Seems to belong to the ATP-dependent AMP-binding enzyme family, and to the short-chain dehydrogenses/reductases (SDR) family. Q9CCT4 No lipid metabolism PF00501,PF00550,PF07993 Q9CCT4 GO:0000036,GO:0048037,GO:0008152,GO:0004043 Rv2590 Rv2590 AL450380.2 Mycobrowser_v4 CDS 1818445 1818573 . - 0 ML1506A ML1506A hypothetical protein(pseudogene) ML1506A, len:128. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-07 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 622160 624886 . + 0 ML0512 alaS Probable alanyl-tRNA synthetase AlaS (Alanine--tRNA ligase) (Alanine translase) AlaRS) ML0512, len: 908 aa. Probable alaS, alanyl-tRNA synthetase (EC 6.1.1.7), highly similar to SYA_MYCTU|O07438|Rv2555c alaS, alanyl-tRNA synthetase from M. tuberculosis (904 aa), Fasta scores: E(): 0, (84.7% identity in 907 aa overlap); and CAD94770|Mb2585c from M. bovis (904 aa). Similar to many e.g. Q9KXP9|SYA_STRCO from Streptomyces coelicolor (890 aa), FASTA scores: E(): 1.5e-117, (52.150% identity in 907 aa overlap). Contains Pfam match to entry PF01411 tRNA-synt_2c, tRNA synthetases class II (A). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Belongs to the class-II aminoacyl-tRNA synthetase family. Q9CCT0 No information pathways PF01411,PF02272,PF07973 Q9CCT0 GO:0004813,GO:0006419,GO:0005737,GO:0003676,GO:0005524 6.1.1.7 Rv2555c Rv2555c AL450380.2 Mycobrowser_v4 CDS 626677 627513 . + 0 ML0515 aroE Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) ML0515, len: 278 aa. Probable aroE, shikimate 5-dehydrogenase (EC 1.1.1.25), highly similar to P95001|AL123456|Rv2552c aroE, shikimate 5-dehydrogenase from M. tuberculosis (269 aa), Fasta scores: E(): 0, (81.5% identity in 270 aa overlap); and CAD94767|Mb2582c from M. bovis (260 aa). Also highly similar, but longer than Q9KH59 Putative shikimate dehydrogenase (fragment) from Mycobacterium marinum (148 aa), FASTA scores: E(): 5.7e-38, (72.848% identity in 151 aa overlap); and Q9F7W3|AROE_METTH from Mycobacterium ulcerans (148 aa). Similar to many e.g. Q9KXQ2|AROE from Streptomyces coelicolor (255 aa), FASTA scores: E(): 1.7e-27, (41.339% identity in 254 aa overlap). Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. Belongs to the shikimate dehydrogenase family. Q9CCS7 No intermediary metabolism and respiration PF01488,PF08501 Q9CCS7 GO:0005737,GO:0055114,GO:0004764,GO:0005488 Rv2552c Rv2552c AL450380.2 Mycobrowser_v4 CDS 709905 710870 . + 0 ML0584 ctaB Probable cytochrome C oxidase assembly factor CtaB ML0584, len: 321 aa. Probable cta, cytochrome C oxidase assembly factor Similar to M. tuberculosis ctaB, Rv1451, cytochrome c oxidase assembly factor, TR:O06809 (EMBL:AL123456) (308 aa), Fasta scores: E(): 0, 82.7% identity in 307 aa overlap. Similar to many e.g. Bacillus firmus ctaB, protoheme IX farnesyltransferase, SW:COXX_BACFI (Q04444) (312 aa), Fasta scores: E(): 7.8e-24, 33.6% identity in 283 aa overlap. Previously sequenced as TR:Q49685 (EMBL:U00013) (300 aa), Fasta scores: E(): 0, 99.7% identity in 300 aa overlap. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01040 UbiA, UbiA prenyltransferase family. Q9CCN4 No intermediary metabolism and respiration PF01040 Q9CCN4 GO:0016021,GO:0005886,GO:0008495,GO:0048034 2.5.1.- Rv1451 Rv1451 AL450380.2 Mycobrowser_v4 CDS 461562 461892 . - 0 ML0369A ML0369A hypothetical protein(pseudogene) ML0369A, len:330. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-31 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 649609 652998 . + 0 ML0536 carB Probable carbamoyl-phosphate synthase large subunit CarB (Carbamoyl-phosphate synthetase ammonia chain) ML0536, len: 1129 aa. Probable carB, Carbamoyl-phosphate synthase large chain (EC 6.3.5.5), highly similar to P57689|CARB_MYCTU|Rv1384 carB, carbamoyl-phosphate synthase subunit from M. tuberculosis (1115 aa), fasta scores: E(): 0, (88.839% identity in 1111 aa overlap) ; and CAD94280|Mb1419 from M. bovis (1115 aa). Highly similar to many e.g. CARB_ECOLI|P00968 carB, carbamoyl-phosphate synthase subunit from Escherichia coli (1072 aa), Fasta scores: (51.4% identity in 1116 aa overlap). Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. SUBUNIT: COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE. Belongs to the CarB family. Q9CCR2 No intermediary metabolism and respiration PF00289,PF02142,PF02786,PF02787 Q9CCR2 GO:0006526,GO:0004088,GO:0000287,GO:0030145,GO:0006221,GO:0005524 6.3.5.5 Rv1384 Rv1384 AL450380.2 Mycobrowser_v4 CDS 1443568 1443810 . + 0 ML1221 ML1221 Conserved hypothetical protein ML1221, len: 80 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49616 (EMBL:U00010) (80 aa), Fasta scores: E(): 0, 98.8% identity in 80 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1590 TR:O06600 (EMBL:Z95586) (79 aa), Fasta scores: E(): 3.4e-21, 67.1% identity in 73 aa overlap. Q49616 No conserved hypotheticals Q49616 Rv1590 Rv1590 AL450380.2 Mycobrowser_v4 CDS 763477 764385 . + 0 ML0631 era Probable GTP-binding protein Era ML0631, len: 302 aa. Probable era, GTP-binding protein, highly similar to ERA_MYCTU|O05834|Rv2364c era, GTP-binding protein from M. tuberculosis (300 aa), Fasta scores: E(): 5.9e-95, (81.4% identity in 301 aa overlap); and CAD97246|Mb2385c (300 aa) from M. bovis. Similar to many bacterial era-homologues and to ERA_ECOLI|P06616 era, GTP-binding protein from Escherichia coli (301 aa), Fasta scores: E(): 3.3e-30, (34.3% identity in 297 aa overlap). Previously sequenced as ERA_MYCLE|Q49768 (302 aa), Fasta scores: E(): 0, (99.7% identity in 302 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). CONTAINS 1 KH TYPE-2 DOMAIN. BELONGS TO THE ERA/TRME FAMILY OF GTP-BINDING PROTEINS, ERA SUBFAMILY. Q49768 No intermediary metabolism and respiration PF01926,PF07650 Q49768 GO:0003723,GO:0005622,GO:0005525 Rv2364c Rv2364c AL450380.2 Mycobrowser_v4 CDS 1844957 1845357 . - 0 ML1529A ML1529A hypothetical protein(pseudogene) ML1529A, len:400. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 796048 797250 . - 0 ML0660c fadE23 Probable acyl-CoA dehydrogenase FadE23 ML0660c, len: 400 aa. Probable fadE23, acyl-CoA dehydrogenase (1.3.99.-), highly similar to P95186|AL123456|Rv3140 fadE23, probable acyl-CoA dehydrogenase from M. tuberculosis (401 aa), Fasta scores: E(): 0, (89.5% identity in 401 aa overlap); and CAD95256|Mb3164 from M. bovis (401 aa). Similar to many e.g. Q9HUH1 Probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (402 aa), fasta scores: opt: 1550, E(): 4.7e-97, (60.0% identity in 400 aa overlap). Also similar to ML0737. Previously sequenced as O32891|Z98271 (400 aa), Fasta scores: E(): 0, (100.0% identity in 400 aa overlap). Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. O32891 No lipid metabolism PF00441,PF02770 O32891 GO:0009055,GO:0008152,GO:0003995 Rv3140 Rv3140 AL450380.2 Mycobrowser_v4 CDS 465203 466624 . + 0 ML0373 ML0373 Conserved hypothetical protein ML0373, len: 473 aa. Conserved hypothetical protein, highly similar to Rv3433c|YY33_MYCTU|O06250 conserved hypothetical protein from M. tuberculosis (473 aa), Fasta scores: E(): 0, (84.6% identity in 473 aa overlap). Similar to many bacterial hypothetical proteins e.g. O86783|SC6G4.20c from Streptomyces coelicolor (485 aa), Fasta scores: E(): 0, (49.1% identity in 489 aa overlap). Previously sequenced as YY33_MYCLE|P37391 (392 aa), Fasta scores: E(): 0, (94.5% identity in 381 aa overlap). Contains Pfam match to entry PF01256 UPF0031, Uncharacterized protein family UPF0031. Contains PS01049 Uncharacterized protein family UPF0031 signature 1. Contains PS01050 Uncharacterized protein family UPF0031 signature 2. P37391 No conserved hypotheticals PF01256,PF03853 P37391 Rv3433c Rv3433c AL450380.2 Mycobrowser_v4 CDS 801977 803347 . - 0 ML0666c fprA Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) ML0666c, len: 456 aa. Probable fprA, NADPH:adrenodoxin oxidoreductase (NADPH-ferredoxin reductase) (EC 1.18.1.2), highly similar to O05783|AL123456|Rv3106 fprA, NADPH:adrenodoxin oxidoreductase from M. tuberculosis (456 aa), Fasta scores: E(): 0, (80.8% identity in 459 aa overlap); and CAD96820|Mb3133 from M. bovis (456 aa). Also similar to other adrenodoxin oxidoreductases e.g. Q9RX19 Putative NADPH:adrenodoxin oxidoreductase from Deinococcus radiodurans (479 aa), fasta scores: opt: 1302, E(): 2.6e-76, (46.799% identity in 453 aa overlap). Also similar to ML2134. Previously sequenced as O32886|Z98271 (456 aa), Fasta scores: E(): 0, (99.8% identity in 456 aa overlap). O32886 No intermediary metabolism and respiration PF07992 O32886 GO:0004324,GO:0055114,GO:0009055 1.18.1.2 Rv3106 Rv3106 AL450380.2 Mycobrowser_v4 CDS 694890 695909 . + 0 ML0570 gap Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) ML0570, len: 339 aa. Probable gap, Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), highly similar to G3P_MYCTU|O06822|Rv1436 gap, Glyceraldehyde 3-phosphate dehydrogenase from M. tuberculosis (339 aa), Fasta scores: E(): 3.6e-124, (89.1% identity in 339 aa overlap); and CAD94332|Mb1471 from M. bovis (339 aa). Similar to many e.g. G3P_MYCAV|P94915 gap, glyceraldehyde 3-phosphate dehydrogenase from Mycobacterium avium (339 aa), Fasta scores: E(): 0, (87.9% identity in 339 aa overlap). Previously sequenced as G3P_MYCLE|P46713 (339 aa), Fasta scores: E(): 0, (99.7% identity in 339 aa overlap). Contains Pfam match to entry PF00044 gpdh, glyceraldehyde 3-phosphate dehydrogenases. Contains PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. Belongs to the Glyceraldehyde 3-phosphate dehydrogenase family. P46713 No intermediary metabolism and respiration PF00044,PF02800 P46713 GO:0005737,GO:0004365,GO:0006096,GO:0055114,GO:0051287 1.2.1.12 Rv1436 Rv1436 AL450380.2 Mycobrowser_v4 CDS 1490902 1495770 . + 0 ML1249 gdh PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE) ML1249, len: 1622 aa. Probable gdh, NAD-dependent glutamate dehydrogenase (EC 1.4.1.2). Similar to several NAD-dependent glutamate dehydrogenase including: Mycobacterium tuberculosis Rv2476c TR:O53203 (EMBL:AL021246) (1624 aa), Fasta scores: E(): 0, 81.5% identity in 1634 aa overlap and Rickettsia prowazekii TR:Q9ZCI2 (EMBL:AJ235273) (1581 aa), Fasta scores: E(): 0, 32.9% identity in 1494 aa overlap. Q7AQ79 No intermediary metabolism and respiration PF05088 Q7AQ79 GO:0003824,GO:0008152,GO:0005488 Rv2476c Rv2476c AL450380.2 Mycobrowser_v4 CDS 385650 386630 . + 0 ML0303 glnH Probable glutamine-binding protein GlnH (GLNBP) ML0303, len: 326 aa. Probable glnH, glutamine-binding protein, membrane-bound lipoprotein (see citation below), highly similar to Rv0411c|P96257|AL123456 glnH, glutamine-binding protein from M. tuberculosis (328 aa), Fasta scores: E(): 0, (79.3% identity in 328 aa overlap). Similar to many bacterial solute-binding proteins e.g. GLNH_BACST|P27676 glnH, glutamine-binding protein from Bacillus stearothermophilus (262 aa), Fasta scores: E(): 3.7e-23, (38.1% identity in 194 aa overlap). Previously sequenced as Q9ZBL7|AL035159 (325 aa), Fasta scores: E(): 0, (100.0% identity in 325 aa overlap). Contains a probable N-terminal signal sequence. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3. Contains PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Belongs to the bacterial solute-binding protein family 3. Presumed attached to the membrane by a lipid anchor. Q9CCX0 No cell wall and cell processes PF00497 Q9CCX0 GO:0006810,GO:0005215,GO:0030288 Rv0411c Rv0411c AL450380.2 Mycobrowser_v4 CDS 1067603 1068517 . + 0 ML0901 ML0901 conserved hypothetical protein ML0901, len: 304 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa), Fasta scores: E(): 0, 99.7% identity in 304 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2172c TR:O53506 (EMBL:AL021957) (301 aa), Fasta scores: E(): 0, 80.9% identity in 299 aa overlap. Q7AQD0 No conserved hypotheticals Q7AQD0 Rv2172c Rv2172c AL450380.2 Mycobrowser_v4 CDS 473559 475172 . + 0 ML0381 groEL1 60 kDa chaperonin 1 GroEL1 (Protein Cpn60-1) (groEL protein 1) ML0381, len: 537 aa. groEL1 (alternate genbe name: cpn60_1), 60 kDa chaperonin 1 (protein cpn60 1) (see citations below), highly similar to Rv3417c|CH61_MYCTU|Q59573 groEL1, 60 kDa chaperonin 1 from M. tuberculosis (539 aa), Fasta scores: E(): 0, (82.9% identity in 539 aa overlap). Also highly similar to others e.g. P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces coelicolor (540 aa), Fasta scores: E(): 0, (82.9% identity in 539 aa overlap). Previously sequenced as CH61_MYCLE|P37578 (537 aa), Fasta scores: E(): 0, (100.0% identity in 537 aa overlap). Contains Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family. Contains PS00296 Chaperonins cpn60 signature. Belongs to the chaperonin (hsp60) family. P37578 No virulence, detoxification, adaptation PF00118 P37578 GO:0005737,GO:0042026,GO:0051082,GO:0005524 Rv3417c Rv3417c AL450380.2 Mycobrowser_v4 CDS 447415 448962 . + 0 ML0354 ilvX Probable acetohydroxyacid synthase IlvX (acetolactate synthase) ML0354, len: 515 aa. Probable ilvX, acetohydroxyacid synthase (EC 4.1.3.18), highly similar to Rv3509c|O53554|AL123456 ilvX, probable acetohydroxyacid synthase from M. tuberculosis (515 aa), Fasta scores: E(): 0, (82.9% identity in 515 aa overlap). Also similar to various enzymes (principally acetohydroxyacid/acetolactate synthases) e.g. ILVI_ECOLI|P00893 ilvI, acetolactate synthase isozyme III large subunit from Escherichia coli (574 aa), Fasta scores: E(): 1.8e-07, (23.7% identity in 540 aa overlap); and MDLC_PSEPU|P20906 mdlC, benzoylformate decarboxylase from Pseudomonas putida (528 aa), Fasta scores: E(): 6.6e-13, (29.3% identity in 529 aa overlap). Previously sequenced as Q49865|U00020 (515 aa), Fasta scores: E(): 0, (99.8% identity in 515 aa overlap). Contains 2 Pfam matches to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Q49865 No intermediary metabolism and respiration PF02775,PF02776 Q49865 GO:0030976,GO:0016829 4.1.3.18 Rv3509c Rv3509c AL450380.2 Mycobrowser_v4 CDS 423179 423937 . - 0 ML0333c ML0333c Conserved hypothetical protein ML0333c, len: 252 aa. Conserved hypothetical protein. N-terminal half is similar to LAMB_EMENI|P38096 lamB, lactam utilization protein from Emericella nidulans (262 aa), Fasta scores: E(): 2.6e-15, (38.3% identity in 128 aa overlap). Similar to many bacterial hypothetical proteins e.g. Q9RL45|AL121596 conserved hypothetical protein SCF51A.19 from Streptomyces coelicolor A3(2) (250 aa), Fasta scores: E(): 0, (58.1% identity in 248 aa overlap). Q9CCW2 No conserved hypotheticals PF03746 Q9CCW2 AL450380.2 Mycobrowser_v4 CDS 1179522 1180502 . - 0 ML1009c ML1009c conserved hypothetical protein ML1009c, len: 326 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49847 (EMBL:U00019) (326 aa), Fasta scores: E(): 0, 100.0% identity in 326 aa overlap. Also highly similar to a number of other proteins of unknown function e.g. Mycobacterium tuberculosis Rv2714 TR:O07213 (EMBL:Z96072) (324 aa), Fasta scores: E(): 0, 89.7% identity in 320 aa overlap. Q7AQB4 No conserved hypotheticals PF01908 Q7AQB4 Rv2714 Rv2714 AL450380.2 Mycobrowser_v4 CDS 2424246 2424417 . + 0 ML2033A ML2033A hypothetical protein(pseudogene) ML2033A, len:171. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.003 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 907184 908416 . + 0 ML0765 manA probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE) ML0765, len: 410 aa. Probable manA, mannose-6-phosphate isomerase (EC 5.3.1.8), highly similar to Rv3255c|MTCY20B11.30c|O05898|Z95121 Probable manA, mannose-6-phosphate isomerase from M. tuberculosis (408 aa), fasta scores: E(): 2.6e-143, (84.4% identity in 411 aa overlap); and CAD95375|Mb3283c from M. bovis (408 aa). Similar to several e.g. Q9KZL9 Mannose-6-phosphate isomerase from Streptomyces coelicolor (383 aa), fasta scores: E(): 6.5e-54, (44.717% identity in 407 aa overlap); and MANA_HUMAN|P34949 mannose-6-phosphate isomerase from Homo sapiens (422 aa), fasta scores: E(): 1.2e-27, (31.0% identity in 432 aa overlap). Contains Pfam match to entry PF01238 PMI_typeI, Phosphomannose isomerase type I. SIMILAR TO FAMILY 1 OF MANNOSE-6-PHOSPHATE ISOMERASES. Q9CCJ5 No intermediary metabolism and respiration PF01238 Q9CCJ5 GO:0004476,GO:0008270,GO:0005975 Rv3255c Rv3255c AL450380.2 Mycobrowser_v4 CDS 895478 896554 . + 0 ML0753 manB INVOLVED IN GDP-MANNOSE BIOSYNTHESIS AND BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE (D-ALPHA-D PATHWAY): GENERATES GDP-MANNOSE AND PHOSPHATE FROM GTP AND ALPHA-D-MANNOSE 1-PHOSPHATE. MANB PRODUCT IS NEEDED FOR ALL MANNOSYL GLYCOLIPIDS AND POLYSACCHARIDES WHICH, LIKE RHAMNOSYL RESIDUES, ARE AN IMPORTANT PART OF THE MYCOBACTERIUM ENVELOPE [CATALYTIC ACTIVITY: ALPHA-D-MANNOSE 1-PHOSPHATE + GTP = GDP-MANNOSE + PHOSPHATE]. Probable D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (D-ALPHA-D-HEPTOSE-1-PHOSPHATE GUANYLYLTRANSFERASE) ML0753, len: 358 aa. Probable manB (alternate gene name: hddC), D-alpha-D-mannose-1-phosphate guanylyltransferase (EC 2.7.7.-) (see citations below), highly similar to Rv3264c|MTCY71.04c|P96869|Z92771 manB D-alpha-D-mannose-1-phosphate guanylyltransferase from Mycobacterium tuberculosis (359 aa), fasta scores: E(): 0, (86.9% identity in 359 aa); and CAD95384|Mb3292c from M. bovis (359 aa). Similar to several e.g. Q8FRK5 Putative mannose-1-phosphate guanyltransferase (372 aa), fasta scores: E(): 9.4e-93, (67.507% identity in 357 aa overlap); and Q9KZK6 Putative nucleotide phosphorylase from Streptomyces coelicolor (360 aa), fasta scores: E(): 6.7e-73, (56.704% identity in 358 aa overlap). Also similar to ML2503 from M. leprae. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Contains 3 Pfam matches to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats). BELONGS TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that previously known as rmlA2. Q9CCK6 No cell wall and cell processes PF00132,PF00483 Q9CCK6 GO:0016779,GO:0009058 Rv3264c Rv3264c AL450380.2 Mycobrowser_v4 CDS 551192 552241 . - 0 ML0451c ML0451c Probable conserved membrane protein ML0451c, len: 349 aa. Probable conserved membrane protein, highly similar to Rv2609c|O06205|AL123456 conserved membrane protein from M. tuberculosis (351 aa), Fasta scores: E(): 0, (77.7% identity in 336 aa overlap). Similar, in part, to hypothetical proteins from Streptomyces coelicolor e.g. SC2E1.17|O69888|AL023797 (172 aa), Fasta scores: E(): 2e-13, 43.3% identity in 150 aa overlap. Previously sequenced as O07146|Z96801 (349 aa), Fasta scores: E(): 0, (100.0% identity in 349 aa overlap); and Q9RYE5|DR0004 mutT/nudIX family protein from Deinococcus radiodurans (350 aa). Contains a possible N-terminal signal sequence. Contains PS00893 mutT domain signature. Belongs to the mutT/nudIX family. Q7AQJ1 No cell wall and cell processes PF00293 Q7AQJ1 GO:0016787 Rv2609c Rv2609c AL450380.2 Mycobrowser_v4 CDS 681704 682783 . + 0 ML0564 ML0564 Conserved hypothetical protein ML0564, len: 359 aa. Conserved hypothetical protein, highly similar to YE22_MYCTU|P71691|Rv1422 Conserved hypothetical protein from M. tuberculosis (342 aa), Fasta scores: E(): 6.8e-113, (85.7% identity in 350 aa overlap); and CAD94318|Mb1457 from M. bovis (342 aa). Conserved in other bacteria e.g. Q8FT62 Conserved hypothetical protein from Corynebacterium efficiens (356 aa), fasta scores: E(): 1.2e-64, (57.372% identity in 312 aa overlap). Contains a match to Pfam entry PF01933, Uncharacterised protein family UPF0052. Q9CCN9 No conserved hypotheticals PF01933 Q9CCN9 Rv1422 Rv1422 AL450380.2 Mycobrowser_v4 CDS 693612 694427 . - 0 ML0569c ML0569c Possible conserved exported protein ML0569c, len: 271 aa. Possible conserved exported protein, highly similar to O06825|AL123456|Rv1433 Possible conserved exported protein from M. tuberculosis (271 aa), Fasta scores: E(): 0, (68.3% identity in 271 aa overlap); and CAD94329|Mb1468 from M. bovis (271 aa). Similar to ML0426, ML2446 and ML2664 from M. leprae. Shows similarity to other proteins in M. tuberculosis e.g. Rv2518c, Rv0116c, Rv0192, Rv0483. Previously sequenced as Q49706|U00013 (271 aa), Fasta scores: E(): 0, (100.0% identity in 271 aa overlap). Contains possible N-terminal signal sequence. Q7AQI6 No cell wall and cell processes PF03734 Q7AQI6 Rv1433 Rv1433 AL450380.2 Mycobrowser_v4 CDS 714235 715032 . - 0 ML0589c ML0589c Possible unidentified antibiotic-transport integral membrane protein ABC transporter ML0589c, len: 265 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), highly similar to O86349|AL123456|Rv1457c Possible unidentified antibiotic-transport integral membrane protein ABC transporter from M. tuberculosis (261 aa), Fasta scores: E(): 3.6e-74, (83.1% identity in 260 aa overlap); and CAD96159|Mb1492c from M. bovis (261 aa). Similar to other bacterial hypothetical membrane proteins e.g. O87317|AF027770 fxtE, hypothetical membrane protein from Mycobacterium smegmatis (236 aa), Fasta scores: E(): 1.6e-60, (77.1% identity in 236 aa overlap). Previously sequenced as Q49703|U00013 (265 aa), Fasta scores: E(): 0, (99.6% identity in 265 aa overlap). Contains hydrophobic, probable membrane-spanning regions. Q7AQH9 No cell wall and cell processes PF01061 Q7AQH9 GO:0016020 Rv1457c Rv1457c AL450380.2 Mycobrowser_v4 CDS 2394520 2394887 . + 0 ML2001B ML2001B hypothetical protein(pseudogene) ML2001B, len:367. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-25 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 766711 767601 . + 0 ML0634 ML0634 INVOLVED IN THE SYNTHESIS OF DECAPRENYL DIPHOSPHATE, A MOLECULE WHICH HAS A CENTRAL ROLE IN THE BIOSYNTHESIS OF MOST FEATURES OF THE MYCOBACTERIAL CELL WALL. ADDS SEVEN MORE ISOPRENE UNITS TO OMEGA,E, Z-FARNESYL DIPHOSPHATE AND RELEASES DECAPRENYL DIPHOSPHATE. Probable Long (C50) chain Z-isoprenyl diphosphate synthase (Z-DECAPRENYL DIPHOSPHATE SYNTHASE) ML0634, len: 296 aa. Probable Long (C50) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.-), highly Similar to UPPS_MYCTU|O05837|Rv2361c Long (C50) chain Z-isoprenyl diphosphate synthase from M. tuberculosis (296 aa), Fasta scores: E(): 3.7e-104, (86.5% identity in 296 aa overlap); and CAD97243|Mb2382c from M. bovis. Similar to several Undecaprenyl pyrophosphate synthetases e.g. UPPS_MICLU|O82827 uppS, undecaprenyl pyrophosphate synthetase from Micrococcus luteus (249 aa), Fasta scores: E(): 5.4e-30, (39.4% identity in 246 aa overlap). Similar to ML2467. Previously sequenced as UPPS_MYCLE|P38119 (296 aa), Fasta scores: E(): 0, (99.7% identity in 296 aa overlap). Contains Pfam match to entry PF01255 UPP_synthetase, Putative undecaprenyl diphosphate synthase. Contains PS01066 Undecaprenyl pyrophosphate synthetase family signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY. P38119 No cell wall and cell processes PF01255 P38119 GO:0051301,GO:0007047,GO:0008834,GO:0009252,GO:0008360,GO:0007049 2.5.1.31 Rv2361c Rv2361c AL450380.2 Mycobrowser_v4 CDS 897972 899639 . - 0 ML0756c ML0756c probable DNA methylase (MODIFICATION METHYLASE) (METHYLTRANSFERASE) ML0756c, len: 555 aa. Probable DNA methylase (EC 2.1.1.-), highly similar to Rv3263|MTCY71.03|P96868|Z92771 Probable DNA methylase from Mycobacterium tuberculosis (553 aa), fasta scores: E(): 8.1e-195, (81.9% identity in 541 aa); CAD95383| from M. bovis (553 aa). Similar to several e.g. MT57_ECOLI|P25240 modification methylase eco57IM from Escherichia coli (544 aa), fasta scores: E(): 7.4e-36, (31.4% identity in 525 aa). Contains PS00092 N-6 Adenine-specific DNA methylases signature. Q9CCK4 No information pathways Q9CCK4 GO:0008168,GO:0003676,GO:0032259 Rv3263 Rv3263 AL450380.2 Mycobrowser_v4 CDS 1850216 1850368 . - 0 ML1533A ML1533A PPE family protein(pseudogene) ML1533A, len:152. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 777177 780128 . + 0 ML0644 ML0644 Probable conserved transmembrane protein ML0644, len: 983 aa. Probable conserved transmembrane protein, with hydrophobic N-terminal domain, highly similar to O53339|AL123456|Rv3193c conserved transmembrane protein from M. tuberculosis (992 aa), Fasta scores: E(): 0, (86.1% identity in 989 aa overlap); and CAD95307|Mb3215c from M. bovis (992 aa). Also similar to O53609|AL123456|Rv0064 putative membrane protein from M. tuberculosis (979 aa), Fasta scores: E(): 5.3e-175, (49.3% identity in 984 aa overlap) and to other bacterial hypothetical membrane proteins. Previously sequenced as O32904|Z98271 (277 aa), Fasta scores: E(): 0, (100.0% identity in 277 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CCM6 No cell wall and cell processes PF03699 Q9CCM6 GO:0005886,GO:0016021 Rv3193c Rv3193c AL450380.2 Mycobrowser_v4 CDS 859918 860589 . - 0 ML0717c ML0717c Probable transcriptional regulator (TetR-family) ML0717c, len: 223 aa. Probable transcriptional regulator tetR-family, highly similar to P96900|AL123456|Rv3295 putative TetR-family transcriptional regulator from M. tuberculosis (221 aa), Fasta scores: E(): 0, (85.5% identity in 220 aa overlap); and CAD95415|Mb3323 from M. bovis (221 aa). Similar to many putative transcriptional regulators e.g. Q9RD77|SCO0800|SCF43.11C Putative TetR-family transcriptional regulator from Streptomyces coelicolor (205 aa), fasta scores: opt: 443, E(): 4.9e-23, (39.500% identity in 200 aa overlap). Previously sequenced as Q49662|U00012 (242 aa), Fasta scores: E(): 0, (100.0% identity in 223 aa overlap). Contains a probable helix-turn-helix motif at aa 33-54 (Score 1535, SD +4.42) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q9CCL4 No regulatory proteins PF00440 Q9CCL4 GO:0003700,GO:0006355 Rv3295 Rv3295 AL450380.2 Mycobrowser_v4 CDS 949043 949450 . - 0 ML0799c ML0799c conserved hypothetical protein ML0799c, len: 135 aa. Conserved hypothetical protein, similar to the N terminus of Rv3224A Conserved hypothetical protein from M. tuberculosis (62 aa), fasta scores: E(): 0.086, (59.375% identity in 32 aa overlap) and the N terminus of Rv3224B Conserved hypothetical protein from M. tuberculosis (72 aa), E(): 4.6e-09, (60.00% identity in 70 aa overlap). Similar to Q9XCD9|AF144091 hypothetical 19.1 kDa protein from M. smegmatis (185 aa), fasta scores: E(): 1e-15, (60.2% identity in 93 aa) and to other hypothetical proteins e.g. YBAK_SALTY|P37174 Protein ybaK in Salmonella typhimurium (159 aa), fasta scores: E(): 6e-08, (40.9% identity in 88 aa). Q9CCI0 No conserved hypotheticals PF04073 Q9CCI0 Rv3224A,Rv3224B Rv3224A,Rv3224B AL450380.2 Mycobrowser_v4 CDS 892064 893533 . - 0 ML0750c ML0750c conserved hypothetical protein (CPSA-RELATED PROTEIN) ML0750c, len: 489 aa. Conserved hypothetical protein, CPSA-related protein, highly similar to Rv3267|MTCY71.07|P96872|Z92771 Conserved hypothetical protein from Mycobacterium tuberculosis (498 aa), fasta scores: E(): 9.8e-150, (78.9% identity in 498 aa), and Rv3484|MTCY13E12.37|O06347|Z95390 cpsA from Mycobacterium tuberculosis (513 aa), fasta scores: E(): 1.6e-45, (34.5% identity in 502 aa). Also similar to hypothetical proteins from capsular polysaccharide biosynthesis loci (homologues of Streptococcus agalactiae cpsX, which may have a regulatory function) and to frnA from a Streptomyces roseofulvus polyketide biosynthesis locus. Similar to ML2247 from M. leprae. Q9CCK9 No conserved hypotheticals PF03816 Q9CCK9 Rv3267 Rv3267 AL450380.2 Mycobrowser_v4 CDS 695912 697162 . + 0 ML0571 pgk Probable phosphoglycerate kinase Pgk ML0571, len: 416 aa. Probable pgk, Phosphoglycerate kinase (EC 2.7.2.3), highly similar to PGK_MYCTU|O06821|Rv1437 pgk, phosphoglycerate kinase from M. tuberculosis (412 aa), Fasta scores: E(): 2.7e-129, (80.6% identity in 412 aa overlap); and CAD94333|Mb1472 from M. bovis (412 aa). Similar to many e.g. PGK_CORGL|Q01655 pgk, phosphoglycerate kinase from Corynebacterium glutamicum (403 aa), Fasta scores: E(): 7.4e-94, (59.2% identity in 407 aa overlap). Previously sequenced as PGK_MYCLE|P46712 (416 aa), Fasta scores: E(): 0, (99.8% identity in 416 aa overlap). Contains Pfam match to entry PF00162 PGK, Phosphoglycerate kinases. Contains PS00111 Phosphoglycerate kinase signature. Belongs to the Phosphoglycerate kinase family. P46712 No intermediary metabolism and respiration PF00162 P46712 GO:0005737,GO:0006096,GO:0004618,GO:0005524 2.7.2.3 Rv1437 Rv1437 AL450380.2 Mycobrowser_v4 CDS 952105 953607 . + 0 ML0803 ML0803 Probable two-component sensor kinase ML0803, len: 500 aa. Probable two-component sensor kinase, highly similar to Rv3220c|MTCY07D11.06|O05846|Z95120 Probable two component sensor kinase from M. tuberculosis (501 aa), fasta scores: E(): 5.1e-165, (81.8% identity in 501 aa), and CAD95338|Mb3246c from M. bovis (501 aa). Similar to others e.g. Q82IW5 Putative two-component system sensor kinase from Streptomyces avermitilis (501 aa), fasta scores: E(): 3.9e-78, (45.892% identity in 499 aa overlap). Contains Pfam match to entry PF00512 signal, Histidine kinase. SEEMS SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES. Q9CCH8 No regulatory proteins PF02518,PF07568,PF08448 Q9CCH8 GO:0018106,GO:0007165,GO:0000155,GO:0005524 Rv3220c Rv3220c AL450380.2 Mycobrowser_v4 CDS 1069305 1069937 . - 0 ML0903c ML0903c conserved hypothetical protein ML0903c, len: 210 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69563 (EMBL:AL022602) (210 aa), Fasta scores: E(): 0, 99.5% identity in 210 aa overlap. Also highly similar to another protein of undefined function from Mycobacterium tuberculosis TR:O53504 (EMBL:AL021957) (206 aa), Fasta scores: E(): 0, 76.7% identity in 210 aa overlap. Q7AQC8 No conserved hypotheticals, intermediary metabolism and respiration PF00583 Q7AQC8 GO:0008152,GO:0008080 Rv2170 Rv2170 AL450380.2 Mycobrowser_v4 CDS 575470 576141 . + 0 ML0474 snoP Probable glutamine amidotransferase SnoP ML0474, len: 223 aa. Probable snoP, glutamine amidotransferase, highly similar to Rv2604c|O06210|AL123456 Probable snoP, glutamine amidotransferase from M. tuberculosis (198 aa), Fasta scores: E(): 0, (82.8% identity in 198 aa overlap). Similar to many bacterial hypothetical proteins and some similarity to amidotransferases e.g. Q9L287|SCL2.12c Hypothetical protein SCO1522 from Streptomyces coelicolor (202 aa), fasta scores: opt: 715, E(): 1.5e-41, (58.854% identity in 192 aa overlap); BAC74542|Q81ZV5 Putative glutamine amidotransferase from Streptomyces avermitilis (201 aa) fasta scores: opt: 709, E(): 3.9e-41, (59.896% identity in 192 aa overlap). Previously sequenced as Q49637|U00011 (219 aa), Fasta scores: E(): 0, (100.0% identity in 219 aa overlap). Contains Pfam match to entry PF01174 SNO glutamine amidotransferase family. Q9CCT5 No intermediary metabolism and respiration PF01174 Q9CCT5 GO:0042823,GO:0016740,GO:0006543 2.6.-.- Rv2604c Rv2604c AL450380.2 Mycobrowser_v4 CDS 569608 569709 . - 0 ML0469A ML0469A hypothetical protein(pseudogene) ML0469A, len:101. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 953667 953921 . - 0 ML0804c whiB1 Probable transcritional regulatory protein WhiB-like WhiB1 ML0804c, len: 84 aa. Probable whiB1, WhiB-like regulatory protein (see citation below), highly similar to Rv3219|MTCY07D11.07c|O05847|Z95120 whiB1, WhiB-like regulatory protein from Mycobacterium (84 aa), fasta scores: E(): 4e-38, (95.2% identity in 84 aa); and CAD95337|Mb3245 from M. bovis (84 aa). Similar to Q9Z6E9|AF073300 whiB3 from Mycobacterium smegmatis fasta scores: E(): 2e-10, (43.2% identity in 81 aa); and to Q9X952 Hypothetical protein wblE from Streptomyces coelicolor (85 aa), fasta scores: E(): 2.3e-29, (72.840% identity in 81 aa overlap). Also similar to ML0382, ML0639, ML0760 and ML2307 Q9CCH7 No regulatory proteins PF02467 Q9CCH7 Rv3219 Rv3219 AL450380.2 Mycobrowser_v4 CDS 2428506 2428967 . - 0 ML2037A ML2037A hypothetical protein(pseudogene) ML2037A, len:461. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-16 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1086008 1087033 . + 0 ML0916 ftsQ POSSIBLE CELL DIVISION PROTEIN FTSQ ML0916, len: 341 aa. Possible ftsQ, cell division protein. Similar to many FtsQ-family proteins thought to be involved in septum formation e.g. Mycobacterium tuberculosis SW:FTSQ_MYCTU (SW:O06226) (314 aa), Fasta scores: E(): 0, 75.4% identity in 297 aa overlap and in parts to Corynebacterium glutamicum SW:FTSQ_CORGL (SW:O24745) (222 aa), Fasta scores: E(): 2.3e-13, 26.6% identity in 203 aa overlap. Contains a possible membrane spanning hydrophobic domain. Q9CCE5 No cell wall and cell processes PF08478 Q9CCE5 Rv2151c Rv2151c AL450380.2 Mycobrowser_v4 CDS 1090814 1091104 . + 0 ML0921 ML0921 Possible conserved transmembrane protein ML0921, len: 96 aa. Possible conserved transmembrane protein. Similar to several proteins of unknown function e.g. Mycobacterium tuberculosis Rv2146c TR:O06230 (EMBL:Z95388) (96 aa), Fasta scores: E(): 2.8e-32, 88.5% identity in 96 aa overlap and Streptomyces coelicolor TR:Q9S2X3 (EMBL:AL109663) (94 aa), Fasta scores: E(): 2.9e-12, 40.7% identity in 86 aa overlap. Contains possible membrane spanning hydrophobic domains. Q9CCE0 No cell wall and cell processes PF02325 Q9CCE0 GO:0016020 Rv2146c Rv2146c AL450380.2 Mycobrowser_v4 CDS 946526 948304 . - 0 ML0798c ML0798c conserved hypothetical protein ML0798c, len: 592 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis ATP/GTP binding protein Rv2787|MTV002.52|O33329|AL008967 fasta scores: E(): 0, 76.5% id in 587 aa and to other M. tuberculosis hypothetical proteins. C-terminal half is similar to that of ML0048 from M. leprae and also similar to ML1536. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CCI1 No conserved hypotheticals Q9CCI1 Rv2787 Rv2787 AL450380.2 Mycobrowser_v4 CDS 951840 952055 . + 0 ML0802 ML0802 Probable biotinylated protein homolog TB7.3 ML0802, len: 71 aa. Probable biotinylated protein TB7.3 homolog, highly similar to Rv3221c|MTCY07d11.05|O05845|Z95120 TB7.3, Biotinylated protein from Mycobacterium tuberculosis (71 aa), fasta scores: E(): 6.2e-19, (90.1% identity in 71 aa) and Q9XCD6|BTB7_MYCSM Biotinylated protein TB7.3 homolog from M. smegmatis (70 aa), fasta scores: E(): 9.8e-18, (85.507% identity in 69 aa overlap). Also similar to the C-terminal half of O54030|AJ002015 mmdC methylmalonyl-CoA decarboxylase, gamma-subunit from Propionigenium modestum (134 aa), fasta scores: E(): 3.4e-06, (42.9% identity in 70 aa). Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes. Contains PS00445 FGGY family of carbohydrate kinases signature 2. Q9CCH9 No lipid metabolism PF00364 Q9CCH9 Rv3221c,Rv3221A Rv3221c,Rv3221A AL450380.2 Mycobrowser_v4 CDS 1116233 1116556 . + 0 ML0946 ML0946 conserved hypothetical protein ML0946, len: 107 aa. Conserved hypothetical protein. Similar in part to several PE-PGRS family protein from M. tuberculosis e.g. Rv1441c|O06818|Z95844 PE-PGRS family protein (491 aa), Fasta scores: E(): 0.00066, (38.7% identity in 106 aa overlap). Identical to the previously sequenced O05568|Z94723 Mycobacterium leprae hypothetical protein (107 aa), Fasta scores: E(): 0, (100.0% identity in 107 aa overlap). Contains Pfam match to entry PF00934 PE, PE family. Q7AQC3 No conserved hypotheticals PF00934 Q7AQC3 AL450380.2 Mycobrowser_v4 CDS 1185459 1185878 . - 0 ML1015c ML1015c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML1015c, len: 139 aa. Probable conserved transmembrane protein. Almost identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49983 (EMBL:U15181) (162 aa), Fasta scores: E(): 0, 100.0% identity in 139 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv2709 TR:O07210 (EMBL:Z96072) (148 aa), Fasta scores: E(): 0, 70.7% identity in 123 aa overlap. Contains possible membrane spanning hydrophobic domains. Q9CCB4 No cell wall and cell processes Q9CCB4 Rv2709 Rv2709 AL450380.2 Mycobrowser_v4 CDS 1013251 1013520 . + 0 ML0853 rpsO PROBABLE 30S RIBOSOMAL PROTEIN S15 RPSO ML0853, len: 89 aa. Probable rpsO, 30s ribosomal protein S15, highly similar to Mycobacterium tuberculosis 30S ribosomal protein S15 rpsO or Rv2785c or MTV002.50C SW:RS15_MYCTU (O33327) (89 aa) fasta scores: E(): 1.1e-32, 92.1% identity in 89 aa and to Bacillus stearothermophilus 30S ribosomal protein S15 rpsO SW:RS15_BACST (P05766) (88 aa) fasta scores: E(): 7.7e-22, 62.5% identity in 88 aa. Previously sequenced as SW:RS15_MYCLE (O32967). Contains Pfam match to entry PF00312 Ribosomal_S15, Ribosomal protein S15. Contains PS00362 Ribosomal protein S15 signature. BELONGS TO THE S15P FAMILY OF RIBOSOMAL PROTEINS. O32967 No information pathways PF00312 O32967 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv2785c Rv2785c AL450380.2 Mycobrowser_v4 CDS 604481 604942 . + 0 ML0498A ML0498A probable dihydrodipicolinate synthetase(pseudogene) ML0498A, len:461. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 7.00E-30 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1364967 1365554 . + 0 ML1166 ML1166 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN ML1166, len: 195 aa. Possible transcriptional regulatory protein. Previously sequenced Mycobacterium leprae hypothetical protein SW:YD32_MYCLE (P53424) (222 aa), Fasta scores: E(): 0, 100.0% identity in 195 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv1332 SW:YD32_MYCTU (Q10643) (218 aa), Fasta scores: E(): 0, 74.4% identity in 195 aa overlap and Streptomyces coelicolor TR:Q9S2G6 (EMBL:AL096852) (202 aa), Fasta scores: E(): 1.5e-05, 34.6% identity in 188 aa overlap. P53424 No regulatory proteins PF09438 P53424 Rv1332 Rv1332 AL450380.2 Mycobrowser_v4 CDS 964704 965729 . + 0 ML0816 ML0816 conserved hypothetical protein ML0816, len: 341 aa. Conserved hypothetical protein. Similar to Rv3207c|MTCY07D11.19|O05859|Z95120 Mycobacterium tuberculosis hypothetical 31.0 kDa protein (285 aa), fasta scores: E(): 0, 80.6% identity in 284 aa, and to CAB94652|AL359215|SC2H12.28c Streptomyces coelicolor putative membrane protein (314 aa), fasta scores: E(): 1e-13, 30.2% identity in 331 aa. Q9CCG9 No conserved hypotheticals Q9CCG9 GO:0006508,GO:0008237 Rv3207c Rv3207c AL450380.2 Mycobrowser_v4 CDS 1040899 1041318 . + 0 ML0876 ML0876 Possible conserved integral membrane protein ML0876, len: 139 aa. Possible conserved integral membrane protein. Similar to Mycobacterium tuberculosis hypothetical 14.9 kDa protein Rv2199c or MTCY190.10C SW:YL99_MYCTU (Q10406) (139 aa) fasta scores: E(): 0, 91.4% identity in 139 aa and to Streptomyces coelicolor hypothetical proteins e.g. putative integral membrane protein SC6G10.27C TR:Q9X812 (EMBL:AL049497) (132 aa) fasta scores: E(): 6.2e-15, 38.8% identity in 139 aa. Q9CCF0 No cell wall and cell processes Q9CCF0 GO:0016021,GO:0055114,GO:0005886,GO:0004129 1.9.3.1 Rv2199c Rv2199c AL450380.2 Mycobrowser_v4 CDS 978255 978677 . - 0 ML0825c ML0825c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY) ML0825c, len: 140 aa. Probable transcriptional regulator, arsR family. Similar to Rv2358|MTCY27.22c|O05840|Z95208 Mycobacterium tuberculosis putative transcriptional regulator (135 aa) fasta scores: E(): 0, 72.9% identity in 140 aa. Contains a probable helix-turn-helix motif at aa 77-98 (Score 1179, SD +3.20) Contains Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family. Belongs to the ARSR family of transciptional regulators. Q9CCG5 No regulatory proteins PF01022 Q9CCG5 GO:0006355,GO:0003700,GO:0005622 Rv2358 Rv2358 AL450380.2 Mycobrowser_v4 CDS 996359 997291 . - 0 ML0839c cysK PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) ML0839c, len: 310 aa. Probable cysK1, cysteine synthase A (EC 4.2.99.8). Similar to Mycobacterium tuberculosis cysteine synthase A cysK or Rv2334 or MTCY98.03 SW:CYSK_MYCTU (P95230) (310 aa) fasta scores: E(): 0, 85.8% identity in 310 aa, and to Spinacia oleracea cysteine synthase, chloroplast precursor cysK SW:CYSL_SPIOL (P32260) (383 aa) fasta scores: E(): 0, 59.2% identity in 309 aa. Previously sequenced as SW:CYSK_MYCLE (O32978). Also similar to ML2396 from M. leprae. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. O32978 No intermediary metabolism and respiration PF00291 O32978 GO:0004124,GO:0030170,GO:0016740,GO:0006535 2.5.1.47 Rv2334 Rv2334 AL450380.2 Mycobrowser_v4 CDS 2629988 2630050 . - 0 ML2212A ML2212A hypothetical protein(pseudogene) ML2212A, len:62. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1008080 1008931 . + 0 ML0849 ML0849 conserved hypothetical protein ML0849, len: 283 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 30.0 kDa protein Rv2325c or MTCY3G12.09 SW:YN25_MYCTU (P71887) (282 aa) fasta scores: E(): 0, 77.3% identity in 282 aa. Similar other bacterial hypothetical proteins e.g. to Bacillus halodurans YbaF protein ybaF TR:Q9Z9J1 (EMBL:AB017508) (265 aa) fasta scores: E(): 3.4e-10, 24.5% identity in 249 aa. Previously sequenced as TR:O32970 (EMBL:Z98741). Q7AQF0 No conserved hypotheticals PF02361 Q7AQF0 GO:0015087,GO:0006824,GO:0009236 Rv2325c Rv2325c AL450380.2 Mycobrowser_v4 CDS 1041505 1042386 . + 0 ML0877 mmpS3 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS3 ML0877, len: 293 aa. Similar to Mycobacterium tuberculosis putative membrane protein mmpS3 or Rv2198c or MTCY190.09C SW:MMS3_MYCTU (Q10390) (299 aa) fasta scores: E(): 0, 69.8% identity in 308 aa. Contains hydrophobic, possible membrane-spanning region. BELONGS TO THE MMPS FAMILY. Q9CCE9 No cell wall and cell processes Q9CCE9 Rv2198c Rv2198c AL450380.2 Mycobrowser_v4 CDS 1022185 1023108 . - 0 ML0860c ML0860c conserved hypothetical protein ML0860c, len: 307 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 31.7 kDa protein Rv2216 or MTCY190.27 SW:YM16_MYCTU (Q10403) (301 aa) fasta scores: E(): 0, 84.2% identity in 297 aa. Similar to many hypothetical proteins from both bacteria and eukaryotes e.g. to Drosophila melanogaster CG8768 TR:Q9V6F9 (EMBL:AE003821) (297 aa) fasta scores: E(): 6.3e-26, 31.3% identity in 304 aa. Previously sequenced as SW:YM16_MYCLE (O32960). O32960 No conserved hypotheticals PF01370,PF08338 O32960 GO:0044237,GO:0050662,GO:0003824 Rv2216 Rv2216 AL450380.2 Mycobrowser_v4 CDS 1192725 1193375 . - 0 ML1025c ML1025c possible conserved secreted protein ML1025c, len: 216 aa. Possible conserved secreted protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49989 (EMBL:U15181) (216 aa), Fasta scores: E(): 0, 99.5% identity in 216 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2700 TR:O07202 (EMBL:Z96072) (216 aa), Fasta scores: E(): 0, 82.4% identity in 216 aa overlap. Contains a possible N-terminal signal sequence. Q7AQB0 No cell wall and cell processes Q7AQB0 Rv2700 Rv2700 AL450380.2 Mycobrowser_v4 CDS 1023124 1024716 . - 0 ML0861c sucB INVOLVED IN THE TRICARBOXYLIC ACID CYCLE. THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF 2-OXOGLUTARATE TO SUCCINYL-COA & CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS: 2-OXOGLUTARATE DEHYDROGENASE (E1), DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3)Involved in tricarboxylic acid cycle; converts 2-oxoglutarate to succinyl-CoA and CO2 [Catalytic activity: Succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide] Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB ML0861c, len: 530 aa. Probable sucB, dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E 2.3.1.61). Similar to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB or Rv2215 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 0, 81.8% identity in 555 aa. Similar to Streptomyces seoulensis dihydrolipoamide acetyltransferase pdhB TR:Q9Z6I4 (EMBL:AF047034) (612 aa) fasta scores: E(): 0, 51.6% identity in 614 aa and to many succinyltransferases e.g. Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB SW:ODO2_ECOLI (P07016) (404 aa) fasta scores: E(): 0, 38.4% identity in 409 aa. Previously sequenced s TR:O32959 (EMBL:Z98741. Contains 2 Pfam matches to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes. Contains Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain). Contains 2 x PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. Belongs to the 2-oxoacid dehydrogenase family. Q7AQE7 No intermediary metabolism and respiration PF00198,PF00364,PF02817 Q7AQE7 GO:0008152,GO:0005515,GO:0008415 Rv2215 Rv2215 AL450380.2 Mycobrowser_v4 CDS 1030184 1031290 . + 0 ML0866 ilvE PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE ML0866, len: 368 aa. Probable ilvE, branched-chain amino acid aminotransferase (EC 2.6.1.42). Similar to Mycobacterium tuberculosis probable branched-chain amino acid aminotransferase ilvE or Rv2210c or MTCY190.21C SW:ILVE_MYCTU (Q10399) (368 aa) fasta scores: E(): 0, 87.2% identity in 368 aa. Similar to many e.g. Mus musculus branched-chain amino acid aminotransferase (cytosolic) bcat1 or eca39 SW:BCAT_MOUSE (P24288) (386 aa) fasta scores: E(): 0, 41.0% identity in 329 aa. Previously sequenced as SW:ILVE_MYCLE (O32954). Contains Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV. Contains PS00770 Aminotransferases class-IV signature. O32954 No intermediary metabolism and respiration PF01063 O32954 GO:0004084,GO:0009082 2.6.1.42 Rv2210c Rv2210c AL450380.2 Mycobrowser_v4 CDS 621920 622114 . + 0 ML0511A ML0511A hypothetical protein(pseudogene) ML0511A, len:194. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1801374 1801727 . - 0 ML1494c ML1494c conserved transmembrane protein ML1494c, len: 117 aa. Probable integral membrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1171 TR:O50427 (EMBL:AL010186) (146 aa), Fasta scores: E(): 7.4e-24, 62.2% identity in 111 aa overlap. Contains possible membrane spanning hydrophobic domains. Q9CBX5 No cell wall and cell processes, conserved hypotheticals Q9CBX5 Rv1171 Rv1171 AL450380.2 Mycobrowser_v4 CDS 1033204 1033893 . - 0 ML0869c ML0869c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML0869c, len: 229 aa. Probable conserved transmembrane protein. Equivalent to Mycobacterium tuberculosis hypothetical protein Rv2206 (MTCY190.17, 236 aa). Two hydrophobic stretches in C-terminal part. FASTA scores: opt: 1052, 67.5% identity in 237 aa overlap. Also similar to part of Streptomyces coelicolor putative integral membrane protein SC5F7.32 TR:Q9S2R7 (EMBL:AL096872) (251 aa) fasta scores: E(): 3.5e-14, 34.7% identity in 219 aa. Previously sequenced as TR:O32952 (EMBL:Z98741). Start changed since first submission, protein longer now. Q9CCF6 No cell wall and cell processes Q9CCF6 GO:0005886,GO:0016021 Rv2206 Rv2206 AL450380.2 Mycobrowser_v4 CDS 1039785 1040846 . + 0 ML0875 ctaC INVOLVED IN AEROBIC RESPIRATION. SUBUNIT I AND II FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. ELECTRONS ORIGINATING IN CYTOCHROME C ARE TRANSFERRED VIA HEME A AND CU(A) TO THE BINUCLEAR CENTER FORMED BY HEME A3 AND CU(B) [Catalytic activity: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O] PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC ML0875, len: 353 aa. Probable ctaC, transmembrane cytochrome C oxidase (subunit II). Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide II precursor ctaC or Rv2200c or MTCY190.11C SW:COX2_MYCTU (Q10375) (363 aa) fasta scores: E(): 0, 85.3% identity in 340 aa. Shows weak similarity to many cytochrome oxidases e.g. to part of Acanthamoeba castellanii cytochrome C oxidase polypeptide I+II cox1/2 SW:COX1_ACACA (Q37370) (873 aa) fasta scores: E(): 7.1e-10, 28.5% identity in 221 aa. Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00116 COX2, Cytochrome C oxidase subunit II. Contains PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. Belongs to the cytochrome c oxidase subunit 2 family. Q9CCF1 No intermediary metabolism and respiration PF00116 Q9CCF1 GO:0004129,GO:0020037,GO:0016021,GO:0005886,GO:0070469,GO:0022904,GO:0006810,GO:0005507 1.9.3.1 Rv2200c Rv2200c AL450380.2 Mycobrowser_v4 CDS 1047667 1048767 . + 0 ML0883 trpD Probable anthranilate phosphoribosyltransferase TrpD ML0883, len: 366 aa. Probable trpD, anthranilate phosphoribosyltransferase (EC 2.4.2.18). Similar to Mycobacterium tuberculosis anthranilate phosphoribosyltransferase trpD or Rv2192c or MTCY190.03C SW:TRPD_MYCTU (Q10382) (370 aa) fasta scores: E(): 0, 80.1% identity in 362 aa. Similar to many e.g. Streptomyces coelicolor anthranilate phosphoribosyltransferase 1 trpD1 or SC6G10.20C SW:TRD1_STRCO (O68608) (354 aa) fasta scores: E(): 0, 48.8% identity in 363 aa. Previously sequenced as SW:TRPD_MYCLE (O69581). Contains Pfam match to entry PF00591 Glycos_transf_3, glycosyl transferase family. O69581 No intermediary metabolism and respiration PF00591,PF02885 O69581 GO:0000162,GO:0004048 2.4.2.18 Rv2192c Rv2192c AL450380.2 Mycobrowser_v4 CDS 2430197 2430352 . + 0 ML2038A ML2038A hypothetical protein(pseudogene) ML2038A, len:155. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1050966 1052090 . + 0 ML0885 ML0885 Putative secreted protein ML0885, len: 374 aa. Putative secreted protein. Similar to Mycobacterium tuberculosis putative secreted protein Rv2190c or MTCY190.01c or MTV021.23C SW:YL90_MYCTU (Q10383; O53524) (385 aa) fasta scores: E(): 0, 69.2% identity in 386 aa. Similar to many putative secreted proteins from Streptomyces coelicolor e.g. putative NPL/P60 family secreted protein SCD63A.04C TR:CAB92656 (EMBL:AL356832) (347 aa) fasta scores: E(): 1.4e-13, 31.7% identity in 357 aa. Previously sequenced as TR:O69580 (EMBL:AL022602). Contains a probable N-terminal signal sequence. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Q7AQE3 No virulence, detoxification, adaptation PF00877 Q7AQE3 Rv2190c Rv2190c AL450380.2 Mycobrowser_v4 CDS 1106682 1107825 . - 0 ML0936c ML0936c Putative group II intron maturase-related protein (pseudogene). ML0936c, len: 1144 bp. Possible pseudogene, similar to several maturases e.g. Q9MD87|AF218567 putative maturase from Cryphonectria parasitica (Cheshnut blight fungus) (778 aa), (blastx scores: 143); and Rv0071|O53616 Putative maturase from M. tuberculosis (235 aa), (blastx scores: 153). Belongs to the LEPREP family of dispersed repeats (see citation below) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1057966 1058700 . + 0 ML0892 ML0892 Probable 1-acylglycerol-3-phosphate O-acyltransferase ML0892, len: 244 aa. Probable 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51). Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69572 (EMBL:AL022602) (244 aa), Fasta scores: E(): 0, 100.0% identity in 244 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2182c TR:O53516 (EMBL:AL021957) (247 aa), Fasta scores: E(): 0, 79.8% identity in 247 aa overlap and several Streptomyces coelicolor putative acyltransferases e.g. TR:CAB76086 (EMBL:AL157956) (223 aa), Fasta scores: E(): 0, 51.1% identity in 221 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. Q7AQD7 No intermediary metabolism and respiration, conserved hypotheticals PF01553 Q7AQD7 GO:0008152,GO:0008415 Rv2182c Rv2182c AL450380.2 Mycobrowser_v4 CDS 1064346 1064750 . + 0 ML0898 ML0898 conserved hypothetical regulatory protein ML0898, len: 134 aa. Conserved hypothetical protein, possibly involved in regulation. Identical to the previously sequenced Mycobacterium leprae putative transcriptional regulator TR:O69567 (EMBL:AL022602) (134 aa), Fasta scores: E(): 0, 99.3% identity in 134 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2175c TR:O5350 (EMBL:AL021957) (146 aa), Fasta scores: E(): 0, 82.1% identity in 134 aa overlap. Contains a probable helix-turn-helix motif at aa 18-39 (Score 1581, SD +4.57) Q7AQD2 No regulatory proteins Q7AQD2 GO:0003677 Rv2175c Rv2175c AL450380.2 Mycobrowser_v4 CDS 1850352 1850701 . - 0 ML1533B ML1533B PPE family protein(pseudogene) ML1533B, len:349. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1071031 1071462 . + 0 ML0905 ML0905 conserved hypothetical protein ML0905, len: 143 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YL66_MYCLE (SW:O69561) (143 aa), Fasta scores: E(): 0, 99.3% identity in 143 aa overlap. Also highly similar to many other proteins of undefined function including: Mycobacterium tuberculosis Rv2166c SW:YL66_MYCTU (SW:O06211) (143 aa), Fasta scores: E(): 0, 92.3% identity in 142 aa overlap and Escherichia coli SW:YABB_ECOLI (SW:P22186) (152 aa), Fasta scores: E(): 3.8e-11, 32.0% identity in 147 aa overlap. O69561 No conserved hypotheticals PF02381 O69561 Rv2166c Rv2166c AL450380.2 Mycobrowser_v4 CDS 1092224 1092616 . + 0 ML0923 ML0923 Probable transmembrane protein ML0923, len: 130 aa. Probable transmembrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2144c TR:O06231 (EMBL:Z95388) (118 aa), Fasta scores: E(): 1.3e-12, 50.4% identity in 129 aa overlap. Contains a possible membrane spanning hydrophobic domain. Q9CCD9 No cell wall and cell processes Q9CCD9 Rv2144c Rv2144c AL450380.2 Mycobrowser_v4 CDS 1081703 1083307 . + 0 ML0913 ftsW FtsW-like protein FtsW ML0913, len: 534 aa. Probable ftsW, cell division protein. Identical to the previously sequenced Mycobacterium leprae cell division protein, FtsW, TR:O69553 (EMBL:AL022602) (534 aa), Fasta scores: E(): 0, 99.8% identity in 534 aa overlap. Also highly similar many other FtsW-family proteins involved in cell wall formation e.g. from Mycobacterium tuberculosis FtsW-like protein SW:FTWH_MYCTU (SW:O06223) (524 aa), Fasta scores: E(): 0, 76.5% identity in 528 aa overlap and Escherichia coli FtsW SW:FTSW_ECOLI (SW:P16457) (414 aa), Fasta scores: E(): 3.6e-31, 37.0% identity in 370 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. Contains PS00041 Bacterial regulatory proteins, araC family signature. O69553 No cell wall and cell processes PF01098 O69553 GO:0051301,GO:0016021,GO:0009252,GO:0007049 Rv2154c Rv2154c AL450380.2 Mycobrowser_v4 CDS 1193571 1193873 . + 0 ML1026 ML1026 conserved hypothetical protein ML1026, len: 100 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q4998. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis Rv2699c TR:O07201 (EMBL:Z96072) (100 aa), Fasta scores: E(): 0, 96.0% identity in 100 aa overlap and Streptomyces coelicolor TR:O54130 (EMBL:AL021530) (98 aa), Fasta scores: E(): 3.4e-26, 70.4% identity in 98 aa overlap. Q7AQA9 No conserved hypotheticals Q7AQA9 Rv2699c Rv2699c AL450380.2 Mycobrowser_v4 CDS 1083304 1084527 . + 0 ML0914 murG ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG ML0914, len: 407 aa. Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase (EC 2.4.1.-). Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.-) SW:MURG_MYCLE (SW:O69552) (407 aa), Fasta scores: E(): 0, 99.8% identity in 407 aa overlap). Also highly similar to orthologues from Mycobacterium tuberculosis Rv2153c SW:MURG_MYCTU (SW:O06224) (410 aa), Fasta scores: E(): 0, 76.3% identity in 401 aa overlap and Escherichia coli SW:MURG_ECOLI (SW:P17443) (354 aa), Fasta scores: E(): 4.2e-21, 38.1% identity in 365 aa overlap. Contains a possible membrane spanning hydrophobic domain. O69552 No cell wall and cell processes PF03033,PF04101 O69552 GO:0019277,GO:0030246,GO:0007049,GO:0051301,GO:0007047,GO:0030259,GO:0009252,GO:0005886,GO:0008360,GO:0050511,GO:0009276 2.4.1.227 Rv2153c Rv2153c AL450380.2 Mycobrowser_v4 CDS 1087299 1088438 . + 0 ML0917 ftsZ cell division protein FtsZ ML0917, len: 379 aa. Probable ftsZ, cell division protein. Highly similar to many proteins essential for cell division including: Mycobacterium tuberculosis Rv2150c SW:FTSZ_MYCTU (O08378) (379 aa), Fasta scores: E(): 0, 96.6% identity in 379 aa overlap and Streptomyces griseus SW:FTSZ_STRGR (P45501) (407 aa), Fasta scores: E(): 0, 68.7% identity in 390 aa overlap. Contains Pfam match to entry PF00091 tubulin, Tubulin/FtsZ family. Contains PS01134 FtsZ protein signature 1. Contains PS01135 FtsZ protein signature 2. Q9CCE4 No cell wall and cell processes PF00091,PF03953 Q9CCE4 GO:0003924,GO:0000917,GO:0007049,GO:0005737,GO:0043234,GO:0051258,GO:0005525 Rv2150c Rv2150c AL450380.2 Mycobrowser_v4 CDS 1089207 1089989 . + 0 ML0919 ML0919 CONSERVED HYPOTHETICAL PROTEIN ML0919, len: 260 aa. Conserved hypothetical protein; could belong to the YGGS/YBL036C/F09E5.8 family. Similar to many proteins of unknown function including: Mycobacterium tuberculosis Rv2148c SW:YL48_MYCTU (O06228) (258 aa), Fasta scores: E(): 0, 73.6% identity in 258 aa overlap and Corynebacterium glutamicum SW:YFZ1_CORGL (O24748) (221 aa), Fasta scores: E(): 7e-22, 41.6% identity in 231 aa overlap. Contains a probable helix-turn-helix motif at aa 78-99 (Score 1061, SD +2.80) Contains Pfam match to entry PF01168 UPF0001, Uncharacterized protein family UPF0001. Contains PS01211 Uncharacterized protein family UPF0001 signature. Q9CCE2 No conserved hypotheticals PF01168 Q9CCE2 Rv2148c Rv2148c AL450380.2 Mycobrowser_v4 CDS 1090057 1090689 . + 0 ML0920 ML0920 CONSERVED HYPOTHETICAL PROTEIN ML0920, len: 210 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2147c TR:O06229 (EMBL:Z95388) (241 aa), Fasta scores: E(): 0, 83.5% identity in 218 aa overlap. Note the Mycobacterium leprae protein is 23 aa shorter. Q9CCE1 No conserved hypotheticals PF04472 Q9CCE1 GO:0043093,GO:0007049,GO:0005737,GO:0005515,GO:0000917 Rv2147c Rv2147c AL450380.2 Mycobrowser_v4 CDS 1859295 1859396 . - 0 ML1540A ML1540A hypothetical protein(pseudogene) ML1540A, len:101. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.40E-02 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1088461 1089210 . + 0 ML0918 yfiH conserved hypothetical protein YfiH ML0918, len: 249 aa. Probable yfiH, conserved hypothetical protein. Similar to many proteins of unknown function including: Mycobacterium tuberculosis Rv2149c TR:O06227 (EMBL:Z95388) (250 aa), Fasta scores: E(): 0, 60.2% identity in 244 aa overlap and Streptomyces griseus SW:YFIH_STRGR (P45496) (246 aa), Fasta scores: E(): 5.8e-21, 38.0% identity in 245 aa overlap. Note both of these examples are also found downstream of FtsZ. Belongs to the UPF0124 family. Q9CCE3 No conserved hypotheticals PF02578 Q9CCE3 Rv2149c Rv2149c AL450380.2 Mycobrowser_v4 CDS 1185906 1186229 . + 0 ML1016 ML1016 conserved hypothetical protein ML1016, len: 107 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae TR:Q49984 (EMBL:U15181) (107 aa), Fasta scores: E(): 0, 99.1% identity in 107 aa overlap. Also highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis conserved hypothetical protein Rv2708c TR:O07209 (EMBL:Z96072) (82 aa), Fasta scores: E(): 9.2e-29, 87.8% identity in 82 aa overlap. Q7AQB3 No conserved hypotheticals Q7AQB3 Rv2708c Rv2708c AL450380.2 Mycobrowser_v4 CDS 1186216 1187208 . - 0 ML1017c ML1017c probable conserved integral membrane protein ML1017c, len: 330 aa. Probable conserved integral membrane protein. Identical to the previously sequenced Mycobacterium leprae TR:Q49985 (EMBL:U15181) (330 aa), Fasta scores: E(): 0, 100.0% identity in 330 aa overlap. Also highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis possible membrane protein Rv2707 TR:O07208 (EMBL:Z96072) (324 aa), Fasta scores: E(): 0, 75.4% identity in 325 aa overlap. Q7AQB2 No cell wall and cell processes, conserved hypotheticals PF03631 Q7AQB2 GO:0004540 Rv2707 Rv2707 AL450380.2 Mycobrowser_v4 CDS 2430491 2430670 . - 0 ML2038B ML2038B putative enoyl-CoA hydratase/isomerase(pseudogene) ML2038B, len:179. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-09 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1193878 1194351 . - 0 ML1027c ML1027c Probable transmembrane protein ML1027c, len: 157 aa. Probable transmembrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49991 (EMBL:U15181) (157 aa), Fasta scores: E(): 0, 99.4% identity in 157 aa overlap. Also highly similar to proteins of unknown function from Mycobacterium tuberculosis Rv2698 TR:O07200 (EMBL:Z96072) (161 aa), Fasta scores: E(): 0, 78.9% identity in 161 aa overlap and Streptomyces coelicolor TR:O54132 (EMBL:AL021530) (154 aa), Fasta scores: E(): 1.1e-08, 33.6% identity in 149 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains a probable helix-turn-helix motif at aa 87-108 (Score 1009, SD +2.62) Q7AQA8 No cell wall and cell processes Q7AQA8 Rv2698 Rv2698 AL450380.2 Mycobrowser_v4 CDS 1200582 1201136 . - 0 ML1037c ML1037c conserved hypothetical protein ML1037c, len: 184 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49999 (EMBL:U15181) (184 aa), Fasta scores: E(): 0, 99.5% identity in 184 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2683 TR:O07185 (EMBL:Z96072) (165 aa), Fasta scores: E(): 0, 73.8% identity in 164 aa overlap. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Q7AQA5 No conserved hypotheticals PF00571 Q7AQA5 Rv2683 Rv2683 AL450380.2 Mycobrowser_v4 CDS 1209290 1210645 . + 0 ML1044 hemY PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) ML1044, len: 451 aa. Probable hemY, protoporphyrinogen oxidase (EC 1.3.3.4). Identical to the previously sequenced Mycobacterium leprae protoporphyrinogen oxidase (EC 1.3.3.4) SW:PPOX_MYCLE (Q50008) (451 aa), Fasta scores: E(): 0, 100.0% identity in 451 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis Rv2677c SW:PPOX_MYCTU (O53230) (426 aa), Fasta scores: E(): 0, 75.8% identity in 429 aa overlap and Bacillus subtilis SW:PPOX_BACSU (P32397) (470 aa), Fasta scores: E(): 2.2e-13, 27.1% identity in 458 aa overlap. Contains Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D). BELONGS TO THE PROTOPORPHYRINOGEN OXIDASE FAMILY. COFACTOR: CONTAINS ONE FAD PER HOMODIMER. Q50008 No intermediary metabolism and respiration PF01593 Q50008 GO:0009055,GO:0006783,GO:0055114,GO:0004729,GO:0005737 1.3.3.4 Rv2677c Rv2677c AL450380.2 Mycobrowser_v4 CDS 1900488 1900560 . - 0 ML1575A ML1575A hypothetical protein(pseudogene) ML1575A, len:72. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1205250 1206539 . - 0 ML1040c ML1040c conserved hypothetical protein ML1040c, len: 429 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q50004 (EMBL:U15181) (429 aa), Fasta scores: E(): 0, 100.0% identity in 429 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2681 TR:O07183 (EMBL:Z96072) (438 aa), Fasta scores: E(): 0, 77.4% identity in 416 aa overlap. The predicted product of this CDS is also weakly similar to several nucleases e.g. Escherichia coli SW:RND_ECOLI (P09155) (375 aa), Fasta scores: E(): 2.4e-08, 26.7% identity in 371 aa overlap ribonuclease D (EC 3.1.26.3). Contains Pfam match to entry PF01612 3_5_exonuclease, 3'-5' exonuclease. Q7AQA4 No conserved hypotheticals PF00570,PF01612 Q7AQA4 GO:0005622,GO:0003676,GO:0006139,GO:0008408 Rv2681 Rv2681 AL450380.2 Mycobrowser_v4 CDS 1206541 1207131 . - 0 ML1041c ML1041c conserved hypothetical protein ML1041c, len: 196 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q50005 (EMBL:U15181) (196 aa), Fasta scores: E(): 0, 99.5% identity in 196 aa overlap. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis Rv2680 TR:O86317 (EMBL:Z96072) (210 aa), Fasta scores: E(): 0, 83.9% identity in 193 aa overlap and Streptomyces coelicolor TR:O69860 (EMBL:AL023702) (238 aa), Fasta scores: E(): 2.9e-25, 43.5% identity in 186 aa overlap. Q7AQA3 No conserved hypotheticals Q7AQA3 Rv2680 Rv2680 AL450380.2 Mycobrowser_v4 CDS 1230647 1230991 . + 0 ML1065 ML1065 conserved hypothetical protein ML1065, len: 114 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49955. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1209 TR:O05310 (EMBL:Z93777) (122 aa), Fasta scores: E(): 1.3e-27, 78.6% identity in 112 aa overlap. Note the N-terminus of this protein is rich in the amino acid valine producing a possible membrane spanning hydrophobic domain. Q7AQ97 No conserved hypotheticals Q7AQ97 Rv1209 Rv1209 AL450380.2 Mycobrowser_v4 CDS 634112 634255 . + 0 ML0523A ML0523A hypothetical protein(pseudogene) ML0523A, len:143. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1292141 1292704 . + 0 ML1116 lprC POSSIBLE LIPOPROTEIN LPRC ML1116, len: 187 aa. Possible lprC, lipoprotein. Highly similar to Mycobacterium tuberculosis putative lipoprotein LrpC Rv1275 TR:O86337 (EMBL:Z77137) (180 aa), Fasta scores: E(): 0, 82.7% identity in 179 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CC86 No cell wall and cell processes Q9CC86 Rv1275 Rv1275 AL450380.2 Mycobrowser_v4 CDS 1228779 1229654 . + 0 ML1063 folP2 PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2) ML1063, len: 291 aa. Probable folP2, dihydropteroate synthase 2 (EC 2.5.1.15). Identical to the previously sequenced Mycobacterium leprae dihydropteroate synthase (EC 2.5.1.15) SWDHPS_MYCLE:. Also highly similar to dihydropteroate synthases from Mycobacterium tuberculosis Rv1207 SW:DHP2_MYCTU (O05308) (318 aa), Fasta scores: E(): 0, 86.2% identity in 290 aa overlap and Escherichia coli SW:DHPS_ECOLI (P26282) (282 aa), Fasta scores: E(): 7.2e-24, 34.4% identity in 270 aa overlap. Also similar to ML0224 from M. leprae. Contains Pfam match to entry PF00809 DHPS, Dihydropteroate synthase. Contains PS00793 Dihydropteroate synthase signature 2. Contains PS00792 Dihydropteroate synthase signature 1. P0C0X2 No intermediary metabolism and respiration PF00809 P0C0X2 GO:0046656,GO:0046677,GO:0004156 2.5.1.15 Rv1207 Rv1207 AL450380.2 Mycobrowser_v4 CDS 1222696 1223649 . - 0 ML1058c ML1058c PROBABLE TRANSFERASE ML1058c, len: 317 aa. Probable tranferase (EC 2.-.-.-). Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49948 (EMBL:U15180) (317 aa), Fasta scores: E(): 0, 99.7% identity in 317 aa overlap and highly similar to Mycobacterium tuberculosis TR:O05302 (EMBL:Z93777) (317 aa), Fasta scores: E(): 0, 84.9% identity in 317 aa overlap. The C-terminus of this protein is also similar to many different transferases e.g. Haemophilus influenzae SW:DAPD_HAEIN (P45284) (275 aa), Fasta scores: E(): 0.00048, 26.7% identity in 131 aa overlap 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (EC 2.3.1.117). Q7AQ99 No intermediary metabolism and respiration Q7AQ99 GO:0016740 Rv1201c Rv1201c AL450380.2 Mycobrowser_v4 CDS 1226445 1227008 . + 0 ML1061 ML1061 conserved hypothetical protein ML1061, len: 187 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49952 (EMBL:U15180) (187 aa), Fasta scores: E(): 0, 100.0% identity in 187 aa overlap. Also highly similar to Mycobacterium tuberculosis TR:O05306 (EMBL:Z93777) (187 aa), Fasta scores: E(): 0, 72.4% identity in 174 aa overlap. Q7AQ98 No conserved hypotheticals PF03641 Q7AQ98 Rv1205 Rv1205 AL450380.2 Mycobrowser_v4 CDS 2057894 2058907 . - 0 ML1706c ML1706c conserved hypothetical protein ML1706c, len: 337 aa. Conserved hypothetical protein. Highly similar to proteins of undefined function from Streptomyces coelicolor TR:Q9Z586 (EMBL:AL035569) (331 aa), Fasta scores: E(): 0, 38.6% identity in 337 aa overlap and Mycobacterium tuberculosis Rv3015c TR:O53262 (EMBL:AL021287) (337 aa), Fasta scores: E(): 0, 78.3% identity in 337 aa overlap. Q9CBR6 No conserved hypotheticals PF01717 Q9CBR6 GO:0009086,GO:0003871 Rv3015c Rv3015c AL450380.2 Mycobrowser_v4 CDS 1249763 1250677 . + 0 ML1087 sugA PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA ML1087, len: 304 aa. Probable sugA, sugar-transport integral membrane protein ABC transporter. Previously sequenced Mycobacterium leprae MalF TR:Q49976 (EMBL:U15180) (310 aa), Fasta scores: E(): 0, 100.0% identity in 304 aa overlap. Also highly similar to many putative membrane transport proteins including: Mycobacterium tuberculosis probable sugar transport protein Rv1236 TR:O50452 (EMBL:AL021006) (307 aa), Fasta scores: E(): 0, 81.8% identity in 292 aa overlap and Thermococcus litoralis inner membrane protein MalF TR:O51924 (EMBL:AF012836) (300 aa), Fasta scores: E(): 0, 39.1% identity in 279 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Q9CCA2 No cell wall and cell processes PF00528 Q9CCA2 GO:0005886,GO:0006810,GO:0005215,GO:0016021 Rv1236 Rv1236 AL450380.2 Mycobrowser_v4 CDS 1371785 1372447 . + 0 ML1175 ML1175 conserved hypothetical protein ML1175, len: 220 aa. Conserved hypothetical protein. Previously sequenced Mycobacterium leprae hypothetical protein TR:Q9S383 (EMBL:AL049191) (220 aa), Fasta scores: E(): 0, 99.5% identity in 220 aa overlap. Also highly similar to many other proteins of undefined function including: Mycobacterium tuberculosis Rv1341 SW:YD41_MYCTU (Q10649) (204 aa), Fasta scores: E(): 0, 82.4% identity in 205 aa overlap and Escherichia coli SW:YGGV_ECOLI (P52061) (197 aa), Fasta scores: E(): 1e-23, 44.8% identity in 203 aa overlap. Contains Pfam match to entry PF01725 Ham1p_like, Ham1 family. P52063 No conserved hypotheticals PF01725 P52063 GO:0017111 3.6.1.15 Rv1341 Rv1341 AL450380.2 Mycobrowser_v4 CDS 1254674 1255663 . + 0 ML1091 mdh PROBABLE MALATE DEHYDROGENASE MDH ML1091, len: 329 aa. Probable mdh, Malate dehydrogenase (EC 1.1.1.37). Identical to the previously sequenced Mycobacterium leprae malate dehydrogenase SW:MDH_MYCLE (P50917) (329 aa), Fasta scores: E(): 0, 99.7% identity in 329 aa overlap. Also highly similar to many other malate dehydrogenases including: Mycobacterium tuberculosis Rv1240 SW:MDH_MYCTU (O54592) (329 aa), Fasta scores: E(): 0, 89.1% identity in 329 aa overlap and Thermus aquaticus SW:MDH_THEFL (P10584) (327 aa), Fasta scores: E(): 0, 63.7% identity in 325 aa overlap. Contains Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Contains PS00068 Malate dehydrogenase active site signature. BELONGS TO THE LDH FAMILY. MDH SUBFAMILY. P50917 No intermediary metabolism and respiration PF00056,PF02866 P50917 GO:0005488,GO:0006096,GO:0006108,GO:0055114,GO:0006099,GO:0030060 1.1.1.37 Rv1240 Rv1240 AL450380.2 Mycobrowser_v4 CDS 1263935 1264609 . - 0 ML1096c ML1096c POSSIBLE MEMBRANE PROTEIN ML1096c, len: 224 aa. Possible membrane protein. Highly similar to Mycobacterium tuberculosis Rv1249c TR:O50464 (EMBL:AL021006) (262 aa), Fasta scores: E(): 0, 67.3% identity in 223 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q9CC96 No cell wall and cell processes Q9CC96 Rv1249c Rv1249c AL450380.2 Mycobrowser_v4 CDS 1301393 1303222 . - 0 ML1122c oppD PROBABLE OLIGOPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER OPPD ML1122c, len: 609 aa. Probable oppD, oligopeptide-transport ATP-binding protein ABC transporter. Highly similar to many putative ABC transport proteins e.g. Escherichia coli SW:YLIA_ECOLI (P75796) (269 aa), BlastP Expect 4.0e-28 Mycobacterium tuberculosis Rv1281c SW:YC81_MYCTU (Q11040 (269 aa), BlastP Expect 4.0e-28. Note, that the N- and C-termini of this CDS are possible duplicates. Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Contains 2 x PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q9CC81 No cell wall and cell processes PF00005,PF08352 Q9CC81 GO:0016887,GO:0015833,GO:0015197,GO:0005524 Rv1281c Rv1281c AL450380.2 Mycobrowser_v4 CDS 1372488 1372847 . - 0 ML1176c ML1176c CONSERVED MEMBRANE PROTEIN ML1176c, len: 119 aa. Conserved membrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD42_MYCLE (P54133) (119 aa), Fasta scores: E(): 0, 100.0% identity in 119 aa overlap. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis Rv1342c TR:YD42_MYCTU and Streptomyces coelicolor TR:Q9X948 (EMBL:AJ237976) (109 aa), Fasta scores: E(): 7.7e-11, 36.5% identity in 96 aa overlap. Contains possible membrane spanning hydrophobic domains. P54133 No cell wall and cell processes P54133 GO:0005886,GO:0016021 Rv1342c Rv1342c AL450380.2 Mycobrowser_v4 CDS 793952 794020 . + 0 ML0656A ML0656A hypothetical protein(pseudogene) ML0656A, len:68. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.002 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1370099 1370881 . + 0 ML1173 ML1173 conserved hypothetical protein ML1173, len: 260 aa. Conserved hypothetical protein. Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa), Fasta scores: E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa), Fasta scores: E(): 0, 43.0% identity in 256 aa overlap. P50474 No conserved hypotheticals P50474 Rv1339 Rv1339 AL450380.2 Mycobrowser_v4 CDS 1304115 1305092 . - 0 ML1124c oppB PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER OPPB ML1124c, len: 325 aa. Probable oppB, oligopeptide-transport integral membrane protein ABC transporter. Highly similar to many membrane transport proteins e.g. Mycobacterium tuberculosis putative peptide transport permease protein Rv1283c SW:YC83_MYCTU (Q10611) (325 aa), Fasta scores: E(): 0, 83.4% identity in 325 aa overlap and Bacillus subtilis oligopeptide transport system permease SW:APPB_BACSU (P42062) (317 aa), Fasta scores: E(): 4.5e-27, 34.1% identity in 328 aa overlap. Contains possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Q9CC79 No cell wall and cell processes PF00528 Q9CC79 GO:0005886,GO:0006810,GO:0005215,GO:0016021 Rv1283c Rv1283c AL450380.2 Mycobrowser_v4 CDS 1322117 1323064 . + 0 ML1131 thrB PROBABLE HOMOSERINE KINASE THRB ML1131, len: 315 aa. Probable thrB, homoserine kinase (EC 2.7.1.39). Identical to the previously sequenced Mycobacterium leprae homoserine kinase (EC 2.7.1.39) SW:KHSE_MYCLE (P45836) (314 aa), Fasta scores: E(): 0, 99.7% identity in 314 aa overlap. Also highly similar to many other homoserine kinases including: Mycobacterium tuberculosis Rv1296 SW:KHSE_MYCTU (Q10603) (316 aa), Fasta scores: E(): 0, 82.0% identity in 311 aa overlap and Corynebacterium glutamicum SW:KHSE_CORGL (P08210) (308 aa), Fasta scores: E(): 0, 48.7% identity in 312 aa overlap. Contains Pfam match to entry PF00288 GHMP_kinases, GHMP kinases putative ATP-binding proteins. Contains PS00627 GHMP kinases putative ATP-binding domain. P45836 No intermediary metabolism and respiration PF00288,PF08544 P45836 GO:0005737,GO:0004413,GO:0016310,GO:0009088,GO:0005524 2.7.1.39 Rv1296 Rv1296 AL450380.2 Mycobrowser_v4 CDS 1372844 1373224 . - 0 ML1177c lprD PROBABLE CONSERVED LIPOPROTEIN LPRD ML1177c, len: 126 aa. Probable lprD, conserved lipoprotein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD43_MYCLE (P54134) (126 aa), Fasta scores: E(): 0, 99.2% identity in 126 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv1343c SW:YD43_MYCTU (Q11013) (126 aa), Fasta scores: E(): 0, 78.4% identity in 125 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. P54134 No cell wall and cell processes P54134 GO:0005886,GO:0016021 Rv1343c Rv1343c AL450380.2 Mycobrowser_v4 CDS 1320967 1322049 . + 0 ML1130 thrC PROBABLE THREONINE SYNTHASE THRC ML1130, len: 360 aa. Probable thrC, threonine synthase (EC 4.2.99.2). Identical to the previously sequenced Mycobacterium leprae probable threonine synthase SW:THRC_MYCLE (P45837;) (360 aa), Fasta scores: E(): 0, 99.7% identity in 360 aa overlap. Also highly similar to many other threonine synthases e.g. Mycobacterium tuberculosis Rv1295 SW:THRC_MYCTU (Q10610) (360 aa), Fasta scores: E(): 0, 94.9% identity in 354 aa overlap and Brevibacterium lactofermentum SW:THRC_BRELA (P09123) (352 aa), Fasta scores: E(): 0, 57.9% identity in 337 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. P45837 No intermediary metabolism and respiration PF00291 P45837 GO:0009088,GO:0004795,GO:0030170 4.2.3.1 Rv1295 Rv1295 AL450380.2 Mycobrowser_v4 CDS 1332059 1333399 . + 0 ML1142 atpH PROBABLE ATP SYNTHASE DELTA CHAIN ATPH ML1142, len: 446 aa. Probable atpH, ATP synthase delta chain (EC 3.6.3.14). Previously sequenced Mycobacterium leprae SW:ATPD_MYCLE (P53006) (446 aa), Fasta scores: E(): 0, 100.0% identity in 446 aa overlap. The N-terminus of this protein shares high sequence identity with many ATP synthase B chain proteins e.g. Haemophilus influenzae SW:ATPF_HAEIN (P43720) (156 aa), Fasta scores: E(): 4.8e-05, 24.8% identity in 153 aa overlap and the C-terminus shares high homology with many ATP synthase [delta] chain proteins e.g. Streptomyces lividans SW:ATPD_STRLI (P50008) (272 aa), Fasta scores: E(): 3.4e-20, 33.1% identity in 266 aa overlap_ATP. Also highly similar over the entire range to Mycobacterium tuberculosis Rv1307 SW:ATPD_MYCTU (Q10594) (446 aa), Fasta scores: E(): 0, 77.8% identity in 446 aa overlap. Contains possible coiled-coils and a possible N-terminal signal sequence. Contains Pfam match to entry PF00213 OSCP, ATP synthase delta (OSCP) subunit. Contains Pfam match to entry PF00430 ATP-synt_B, ATP synthase B/B' CF(0). Contains PS01094 Uncharacterized protein family UPF0076 signature. P53006 No intermediary metabolism and respiration PF00213,PF00430 P53006 GO:0046933,GO:0016021,GO:0005886,GO:0045261,GO:0045263,GO:0046961,GO:0015986 Rv1307 Rv1307 AL450380.2 Mycobrowser_v4 CDS 805539 805782 . + 0 ML0668A ML0668A hypothetical protein(pseudogene) ML0668A, len:243. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.021 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1338890 1339465 . - 0 ML1149c ML1149c conserved hypothetical protein ML1149c, len: 191 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD14_MYCLE (P53523) (191 aa), Fasta scores: E(): 0, 100.0% identity in 191 aa overlap. Also similar to many other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1314c SW:YD14_MYCTU (Q10622) (193 aa), Fasta scores: E(): 0, 81.2% identity in 191 aa overlap. Contains Pfam match to entry PF01923 DUF80, Protein of unknown function. P53523 No conserved hypotheticals PF01923 P53523 GO:0008817,GO:0009236,GO:0005737,GO:0005524 2.5.1.17 Rv1314c Rv1314c AL450380.2 Mycobrowser_v4 CDS 1354283 1355188 . + 0 ML1159 ML1159 POSSIBLE THIOREDOXIN ML1159, len: 301 aa. Possible thioredoxin. Previously sequenced Mycobacterium leprae TR:Q49716 (EMBL:U00014) (255 aa), Fasta scores: E(): 0, 100.0% identity in 217 aa overlap. Highly similar to Mycobacterium tuberculosis Rv1324 SW:YD24_MYCTU (Q10636) (304 aa), Fasta scores: E(): 0, 72.4% identity in 301 aa overlap. Also weakly similar in parts to several putative thioredoxins e.g. Alicyclobacillus acidocaldarius SW:THIO_ALIAC (P80579) (105 aa), Fasta scores: E(): 0.00045, 27.1% identity in 107 aa overlap. Q9CC76 No intermediary metabolism and respiration PF00085 Q9CC76 GO:0045454 Rv1324 Rv1324 AL450380.2 Mycobrowser_v4 CDS 1370971 1371750 . + 0 ML1174 rphA RNase PH IS A PHOSPHOROLYTIC EXORIBONUCLEASE THAT REMOVES NUCLEOTIDE RESIDUES FOLLOWING THE -CCA TERMINUS OF tRNA AND ADDS NUCLEOTIDES TO THE ENDS OF RNA MOLECULES BY USING NUCLEOSIDE DIPHOSPHATES AS SUBSTRATES [CATALYTIC ACTIVITY: {TRNA}(N+1) + PHOSPHATE = {TRNA}(N) + A NUCLEOSIDE DIPHOSPHATE]. PROBABLE RIBONUCLEASE RPHA (RNase PH) (tRNA nucleotidyltransferase) ML1174, len: 259 aa. Probable rphA ribonuclease (EC 2.7.7.56). Identical to the previously sequenced Mycobacterium leprae probable ribonuclease PH SW:RNPH_MYCLE (P37939) (259 aa), Fasta scores: E(): 0, 99.6% identity in 259 aa overlap. Also highly similar to many other ribonucleases including: Mycobacterium tuberculosis Rv1340 SW:RNPH_MYCTU (Q10628) (259 aa), Fasta scores: E(): 0, 88.8% identity in 259 aa overlap and Escherichia coli SW:RNPH_ECOLI (P03842) (238 aa), Fasta scores: E(): 0, 55.7% identity in 237 aa overlap. Contains Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease family. Contains PS01277 Ribonuclease PH signature. P37939 No information pathways PF01138,PF03725 P37939 GO:0000049,GO:0009022,GO:0008033,GO:0004549,GO:0000175 2.7.7.56 Rv1340 Rv1340 AL450380.2 Mycobrowser_v4 CDS 837528 837674 . + 0 ML0699A ML0699A deoA; hymidine phosphorylase(pseudogene) ML0699A, len:146. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1380642 1380944 . - 0 ML1181c esxK2 Putative ESAT-6 like protein EsxK2 ML1181c, len: 100 aa. Putative esxK2, ESAT-6 like protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein Q49945|U15180 (100 aa), Fasta scores: E(): 0, (100.0% identity in 100 aa overlap). Identical to ML1055 a possible orthologue of M. tuberculosis esxK. Also similar to several putative Esat-6 like proteins from M. tuberculosis e.g. O05299|ESXK_MYCTU ESAT-6 like protein esxK (98 aa), fasta scores: E(): 1.2e-19, (58.333% identity in 96 aa overlap). SEEMS TO BELONG TO THE ESAT6 FAMILY. Q49945 No cell wall and cell processes Q49945 Rv1197 Rv1197 AL450380.2 Mycobrowser_v4 CDS 1395294 1396013 . + 0 ML1190 ML1190 conserved hypothetical protein ML1190, len: 239 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q9X7E1 (EMBL:AL049478) (239 aa), Fasta scores: E(): 0, 100.0% identity in 239 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv2525c TR:P95028 (EMBL:Z83863) (240 aa), Fasta scores: E(): 0, 82.2% identity in 241 aa overlap. Q7AQ86 No conserved hypotheticals PF08924,PF10518 Q7AQ86 Rv2525c Rv2525c AL450380.2 Mycobrowser_v4 CDS 1406366 1407694 . + 0 ML1193 ML1193 conserved hypothetical protein ML1193, len: 442 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q9X7E4 (EMBL:AL049478) (442 aa), Fasta scores: E(): 0, 100.0% identity in 442 aa overlap and highly similar to Mycobacterium tuberculosis hypothetical protein Rv2522c TR:O53227 (EMBL:AL021185) (470 aa), Fasta scores: E(): 0, 86.4% identity in 440 aa overlap. Contains Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40. Q7AQ84 No conserved hypotheticals PF01546,PF07687 Q7AQ84 GO:0046983,GO:0006508,GO:0008237 Rv2522c Rv2522c AL450380.2 Mycobrowser_v4 CDS 1417756 1418682 . + 0 ML1200 ML1200 possible pseudouridine synthase ML1200, len: 308 aa. Possible pseudouridine synthase. Identical to the previously sequenced Mycobacterium leprae putative pseudouridine synthase TR:Q9X7E8 (EMBL:AL049478) (308 aa), Fasta scores: E(): 0, 99.7% identity in 308 aa overlap orthologues of which are known to be responsible for the synthesis pseudouridine from uracil within the 23s rRNA. Also highly similar to several others e.g. Mycobacterium tuberculosis Rv1540 SW:Y04P_MYCTU (Q10786) (308 aa), Fasta scores: E(): 0, 88.9% identity in 307 aa overlap and Escherichia coli SW:RLUD_ECOLI (P33643) (326 aa), Fasta scores: E(): 9.8e-23, 34.3% identity in 312 aa overlap. Contains Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase. Contains PS01129 Rlu family of pseudouridine synthase signature. Q7AQ83 No information pathways, conserved hypotheticals PF00849,PF01479 Q7AQ83 GO:0009982,GO:0001522,GO:0003723 5.4.99.- Rv1540 Rv1540 AL450380.2 Mycobrowser_v4 CDS 1693104 1693607 . + 0 ML1411 argR Probable Arginine repressor ArgR (AHRC) ML1411, len: 167 aa. Probable argR, Arginine repressor. Highly similar to many ArgR orthologues (which regulate the arginine biosynthetic genes) including: Bacillus stearothermophilus SW:ARGR_BACST (O31408) (149 aa), Fasta scores: E(): 2.3e-10, 33.8% identity in 154 aa overlap and Mycobacterium tuberculosis Rv1657 SW:ARGR_MYCTU (P94992) (170 aa), Fasta scores: E(): 0, 79.7% identity in 158 aa overlap. Belongs to the argR family. P57992 No regulatory proteins PF01316,PF02863 P57992 GO:0005737,GO:0006355,GO:0006350,GO:0003700,GO:0006526 Rv1657 Rv1657 AL450380.2 Mycobrowser_v4 CDS 1442505 1443542 . + 0 ML1220 bioB PROBABLE BIOTIN SYNTHETASE BIOB ML1220, len: 345 aa. Probable bioB, biotin synthetase (EC 2.8.1.-). Identical to the previously sequenced Mycobacterium leprae biotin synthase SW:BIOB_MYCLE (P46715) (345 aa), Fasta scores: E(): 0, 99.1% identity in 345 aa overlap. Also highly similar to several others involved in biotin biosynthesis e.g. Escherichia coli SW:BIOB_ECOLI (P12996) (346 aa), Fasta scores: E(): 0, 35.3% identity in 309 aa overlap and Mycobacterium tuberculosis Rv1589 TR:BIOB_MYCTU (349 aa), fasta scores: E(): 5.9e-131, (87.106% identity in 349 aa overlap). Contains Pfam match to entry PF01792 Biotin_synth, Biotin synthase. P46715 No intermediary metabolism and respiration PF04055,PF06968 P46715 GO:0051539,GO:0009102,GO:0004076,GO:0005506,GO:0051537 2.8.1.6 Rv1589 Rv1589 AL450380.2 Mycobrowser_v4 CDS 1443807 1444403 . + 0 ML1222 ML1222 CONSERVED TRANSMEMBRANE PROTEIN ML1222, len: 198 aa. Conserved transmembrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49626 (EMBL:U00010) (198 aa), Fasta scores: E(): 0, 99.5% identity in 198 aa overlap. Highly similar to proteins of undefined function also found downstream of BioB orthologues in Mycobacterium tuberculosis Rv1591 TR:O06599 (EMBL:Z95586) (221 aa), Fasta scores: E(): 0, 63.8% identity in 188 aa overlap and Mycobacterium bovis BCG TR:O52590 (EMBL:AF041819) (193 aa), Fasta scores: E(): 0, 67.6% identity in 170 aa overlap. Q49626 No cell wall and cell processes Q49626 GO:0005886,GO:0016021 Rv1591 Rv1591 AL450380.2 Mycobrowser_v4 CDS 1449351 1450211 . + 0 ML1227 nadC Probable nicotinate-nucleotide pyrophosphatase NadC ML1227, len: 286 aa. Probable nadC, nicotinate-nucleotide pyrophosphatas (EC 2.4.2.19). Identical to the previously sequenced Mycobacterium leprae nicotinate-nucleotide pyrophosphorylase [carboxylating] (quinolinate phosphoribosyltransferase [decarboxylating]) SW:NADC_MYCLE (P46714) (284 aa), Fasta scores: E(): 0, 100.0% identity in 284 aa overlap. Also highly similar several others from to Mycobacterium tuberculosis Rv1596 SW:NADC_MYCTU (O06594) (285 aa), Fasta scores: E(): 0, 79.2% identity in 283 aa overlap and Escherichia coli SW:NADC_ECOLI (P30011) (296 aa), Fasta scores: E(): 2.6e-32, 40.4% identity in 272 aa overlap. Contains Pfam match to entry PF01729 QRPTase, Quinolinate phosphoribosyl transferase. P46714 No intermediary metabolism and respiration PF01729,PF02749 P46714 GO:0004514,GO:0009435 2.4.2.19 Rv1596 Rv1596 AL450380.2 Mycobrowser_v4 CDS 933379 933450 . - 0 ML0789A ML0789A hypothetical protein(pseudogene) ML0789A, len:71. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-48 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1454302 1460658 . + 0 ML1229 pks4 PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 ML1229, len: 2118 aa. Probable pks4, polyketide beta-ketoacyl synthase. Highly similar at the N-terminus to O50436|Rv1180 pks3 Beta-ketoacyl synthase from M. tuberculosis (488 aa), fasta scores: E(): 5.7e-150, (81.352% identity in 488 aa overlap) and in the C-terminus to O50437|Rv1181 pks4, Polyketide synthase from M. tuberculosis (1582 aa), fasta scores: E(): 0, (75.326% identity in 1609 aa overlap). In M. tuberculosis pks3 and pks4 may represent separate modules of the polyketide synthase. Highly similar to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa), Fasta scores: E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa), Fasta scores: E(): 0, 58.8% identity in 2127 aa overlap. Highly similar to many other M. leprae polyketide synthases ML0101, ML0135, ML0139, ML2353, ML2354, ML2355, ML2356 and ML2357. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q49624 No lipid metabolism PF00106,PF00107,PF00109,PF00550,PF00698,PF02801,PF08240 Q49624 GO:0009058,GO:0048037,GO:0055114,GO:0016491,GO:0016740,GO:0008270,GO:0000036 Rv1180 Rv1180 AL450380.2 Mycobrowser_v4 CDS 854541 854738 . + 0 ML0714A ML0714A sulfatase family protein(pseudogene) ML0714A, len:197. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-07 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1465615 1466691 . - 0 ML1232c ML1232c conserved hypothetical protein ML1232c, len: 358 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49633 (EMBL:U00010) (391 aa), Fasta scores: E(): 0, 100.0% identity in 358 aa overlap. Also highly similar to Mycobacterium tuberculosis Possible exported protein Rv1184c TR:O50440 (EMBL:AL010186) (359 aa), Fasta scores: E(): 0, 62.7% identity in 338 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CC62 No conserved hypotheticals, cell wall and cell processes PF08237 Q9CC62 Rv1184c Rv1184c AL450380.2 Mycobrowser_v4 CDS 1466856 1467548 . - 0 ML1233c ML1233c conserved integral membrane protein ML1233c, len: 230 aa. Conserved integral membrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein Q49630|U00010 (230 aa), Fasta scores: E(): 0, (100.0% identity in 230 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical protein Rv3821|O07802|Z97188 (237 aa), Fasta scores: E(): 2.9e-31, (46.7% identity in 240 aa overlap). Contains multiple possible membrane spanning hydrophobic domains. Q49630 No cell wall and cell processes Q49630 Rv3821 Rv3821 AL450380.2 Mycobrowser_v4 CDS 962710 963297 . - 0 ML0813c ML0813c possible membrane protein ML0813c, len: 195 aa. Possible membrane protein. Similar to Rv3209|MTCY07D11.17c|O05857|Z95120 Mycobacterium tuberculosis Conserved hypothetical thr-, pro-rich protein (186 aa), fasta scores: E(): 8.5e-23, (58.4% identity in 185 aa) and to Rv2198c|MTCY190.09c|MMS3_MYCTU|Q10390 Mycobacterium tuberculosis putative membrane protein mmpS3 (299 aa) fasta scores: E(): 9.4e-08, 31.0% identity in 203 aa. Also similar to ML0431 and ML0877 from M. leprae. Contains N-terminal hydrophobic region. Q9CCH2 No cell wall and cell processes, conserved hypotheticals Q9CCH2 Rv3209 Rv3209 AL450380.2 Mycobrowser_v4 CDS 1503646 1504779 . + 0 ML1258 hisC Probable histidinol-phosphate aminotransferase 1 HisC (Imidazole acetol-phosphate transaminase 1) ML1258, len: 377 aa. Probable hisC, histidinol-phosphate aminotransferase 1 (EC 2.6.1.9). Highly similar to many histidinol-phosphate aminotransferases involved in histidine biosynthesis e.g. Mycobacterium tuberculosis Rv1600 TR:SW:HIS8_MYCTU (O06591) (380 aa), Fasta scores: E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa), Fasta scores: E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. HISTIDINOL-PHOSPHATE AMINOTRANSFERASES SUBFAMILY Q9X7B8 No intermediary metabolism and respiration PF00155 Q9X7B8 GO:0004400,GO:0030170,GO:0000105 2.6.1.9 Rv1600 Rv1600 AL450380.2 Mycobrowser_v4 CDS 1505405 1506025 . + 0 ML1260 hisH Histidine biosynthesis (fifth step). IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR. [CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O]. Imidazole glycerol phosphate synthase subunit HisH (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit hisH) (ImGP synthase subunit hisH) ML1260, len: 206 aa. Probable hisH, Imidazole glycerol phosphate synthase subunit (EC 2.4.2.-). Highly similar to many amidotransferases involved in histidine biosynthesis including: Mycobacterium tuberculosis HisH (Rv1602) TR:O06589 (EMBL:Z95586) (206 aa), Fasta scores: E(): 0, 79.4% identity in 204 aa overlap and Escherichia coli SW:HIS5_ECOLI (P10375) (196 aa), Fasta scores: E(): 3.9e-20, 41.5% identity in 205 aa overlap. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO THE HISH FAMILY. Q9X7C0 No intermediary metabolism and respiration PF00117 Q9X7C0 GO:0006541,GO:0000105,GO:0000107,GO:0005737 2.4.2.- Rv1602 Rv1602 AL450380.2 Mycobrowser_v4 CDS 1519221 1519661 . + 0 ML1276 ML1276 conserved membrane protein ML1276, len: 146 aa. Conserved membrane protein. Similar to several proteins of undefined function including: Mycobacterium tuberculosis Rv1616 TR:O06133 (EMBL:Z95554) (132 aa), Fasta scores: E(): 0, 68.5% identity in 127 aa overlap and Streptomyces coelicolor TR:Q9S2U5 (EMBL:AL096884) (148 aa), Fasta scores: E(): 5.3e-11, 41.4% identity in 128 aa overlap. Contains possible membrane spanning hydrophobic domains. Q9CC50 No cell wall and cell processes Q9CC50 Rv1616 Rv1616 AL450380.2 Mycobrowser_v4 CDS 1516635 1517447 . + 0 ML1273 trpA tryptophan biosynthesis pathway (fifth - last step). THE ALPHA SUBUNIT IS RESPONSIBLE FOR THE ALDOL CLEAVAGE OF INDOLEGLYCEROL PHOSPHATE TO INDOLE AND GLYCERALDEHYDE 3- PHOSPHATE. [CATALYTIC ACTIVITY: L-SERINE + 1-(INDOL-3-YL)GLYCEROL 3-PHOSPHATE = L-TRYPTOPHAN + GLYCERALDEHYDE 3-PHOSPHATE + H(2)O.] Probable tryptophan synthase, alpha subunit TrpA ML1273, len: 270 aa. Probable trpA, tryptophan synthase, alpha subunit (EC 4.2.1.20). Highly similar to many tryptophan synthases [alpha chain] involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1613 SW:TRPA_MYCTU (O06130) (270 aa), Fasta scores: E(): 0, 86.0% identity in 265 aa overlap and Streptomyces coelicolor SW:TRPA_STRCO (O68816) (271 aa), Fasta scores: E(): 0, 46.4% identity in 261 aa overlap. Contains Pfam match to entry PF00290 trp_syntA, Tryptophan synthase alpha chain. Belongs to the trpA family. Q9CC53 No intermediary metabolism and respiration PF00290 Q9CC53 GO:0004834,GO:0000162 4.2.1.20 Rv1613 Rv1613 AL450380.2 Mycobrowser_v4 CDS 1515385 1516638 . + 0 ML1272 trpB tryptophan biosynthesis pathway (fifth last step). THE BETA SUBUNIT IS RESPONSIBLE FOR THE SYNTHESIS OF L-TRYPTOPHAN FROM INDOLE AND L-SERINE. [CATALYTIC ACTIVITY : L-SERINE + 1-(INDOL-3-YL)GLYCEROL 3-PHOSPHATE = L-TRYPTOPHAN + GLYCERALDEHYDE 3-PHOSPHATE + H(2)O] Probable tryptophan synthase, beta subunit TrpB ML1272, len: 417 aa. Probable trpB, tryptophan synthase, beta subunit (EC 4.2.1.20). Highly similar to many tryptophan synthases [beta chain] involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1612 SW:TRPB_MYCTU (O08376) (410 aa), Fasta scores: E(): 0, 86.7% identity in 407 aa overlap and Streptomyces coelicolor SW:TRPB_STRCO (O05625) (427 aa), Fasta scores: E(): 0, 65.2% identity in 405 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. Q9CC54 No intermediary metabolism and respiration PF00291 Q9CC54 GO:0000162,GO:0004834,GO:0030170 4.2.1.20 Rv1612 Rv1612 AL450380.2 Mycobrowser_v4 CDS 1514503 1515321 . + 0 ML1271 trpC Probable indole-3-glycerol phosphate synthase TrpC ML1271, len: 272 aa. Probable trpC, indole-3-glycerol phosphate synthase (EC 4.1.1.48). Highly similar to many indole-3-glycerol phosphate synthases involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1611 SW:TRPC_MYCTU (O06129) (272 aa), Fasta scores: E(): 0, 90.8% identity in 272 aa overlap and Streptomyces coelicolor SW:TRC1_STRCO (O68814) (269 aa), Fasta scores: E(): 0, 64.1% identity in 262 aa overlap. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. Contains PS00614 Indole-3-glycerol phosphate synthase signature. Q9X7C7 No intermediary metabolism and respiration PF00218 Q9X7C7 GO:0000162,GO:0004425 4.1.1.48 Rv1611 Rv1611 AL450380.2 Mycobrowser_v4 CDS 1733643 1734476 . - 0 ML1440c ppm1a Polyprenol-monophosphomannose synthase Ppm1a ML1440c, len: 277 aa. Probable ppm1a, Polyprenol-monophosphomannose synthase. Highly similar to C-terminus of a Polyprenol-monophosphomannose synthase from Mycobacterium tuberculosis Rv2051c TR:O53493 (EMBL:AL021899) (874 aa), Fasta scores: E(): 0, 78.9% identity in 275 aa overlap. Homology to Rv2051c continues downstream of this ORF in a different frame suggesting a possible frameshift. Also similar to other glycosyl transferases e.g. Q827K1 Putative glycosyl transferase from Streptomyces avermitilis (265 aa), fasta scores: E(): 1.3e-57, (56.274% identity in 263 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Q7AQ50 No cell wall and cell processes PF00535 Q7AQ50 Rv2051c Rv2051c AL450380.2 Mycobrowser_v4 CDS 1555823 1556647 . - 0 ML1306c ML1306c conserved hypothetical protein ML1306c, len: 274 aa. Conserved hypothetical protein. Similar to several proteins of unknown function including: Mycobacterium tuberculosis Rv2125 TR:O33260 (EMBL:Z97559) (292 aa), Fasta scores: E(): 0, 85.0% identity in 274 aa overlap and Streptomyces coelicolor TR:Q9S2K6 (EMBL:AL109732) (312 aa), Fasta scores: E(): 1.6e-07, 23.4% identity in 278 aa overlap. Q9CC38 No conserved hypotheticals PF01908 Q9CC38 Rv2125 Rv2125 AL450380.2 Mycobrowser_v4 CDS 1036452 1037426 . + 0 ML0873 adk Probable adenosine kinase adk ML0873, len: 324 aa. Probable adk, adenosine kinase (EC 2.7.1.20). Similar to Mycobacterium tuberculosis adk, adenosine kinase Rv2202c or MTCY190.13C SW:YM02_MYCTU (Q10391) (324 aa) fasta scores: E(): 0, 83.3% identity in 324 aa, and to Streptomyces coelicolor putative kinase SC6G10.31C TR:Q9X816 (EMBL:AL049497) (338 aa) fasta scores: E(): 0, 58.9% id in 319 aa. Shows weak similarity to known kinases e.g. Bacillus subtilis ribokinase rbsK SW:RBSK_BACSU (P36945; P96733) (293 aa) fasta scores: E(): 1.2e-07, 26.1% identity in 283 aa. Contains Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase. Contains PS00583 pfkB family of carbohydrate kinases signature 1. Belongs to the carbohydrate kinase pfkB family. Previously known as cbhK. Q9CCF3 No intermediary metabolism and respiration PF00294 Q9CCF3 GO:0016301 Rv2202c Rv2202c AL450380.2 Mycobrowser_v4 CDS 1416025 1416957 . - 0 ML1198c ansA Probable L-aparaginase AnsA ML1198c, len: 310 aa. Probable L-asparaginase (EC 3.5.1.1). Identical to the previously sequenced Mycobacterium leprae probable L-asparaginase SW:ASPG_MYCLE (Q9X7E6) (310 aa), Fasta scores: E(): 0, 100.0% identity in 310 aa overlap. Also highly similar to many other L-asparaginases e.g. Mycobacterium tuberculosis Rv1538c SW:ASPG_MYCTU (Q10759) (315 aa), Fasta scores: E(): 0, 72.4% identity in 315 aa overlap and Saccharomyces cerevisiae SW:ASG1_YEAST (P38986) (381 aa), Fasta scores: E(): 6.4e-12, 27.5% identity in 327 aa overlap. Also similar to ML2343 a possible pseudogene similar to M. tuberculosis ansA. Contains Pfam match to entry PF00710 Asparaginase, Asparaginase. Contains PS00917 Asparaginase / glutaminase active site signature 2. Contains PS00144 Asparaginase / glutaminase active site signature 1. Belongs to the asparaginase 1 family. Q9X7E6 No intermediary metabolism and respiration PF00710 Q9X7E6 GO:0004067,GO:0005737,GO:0006520 3.5.1.1 Rv1538c Rv1538c AL450380.2 Mycobrowser_v4 CDS 1061590 1062978 . + 0 ML0896 aroG Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phenylalanine-repressible) ML0896, len: 462 aa. Probable aroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (EC 4.1.2.15). Highly similar to many others e.g. Mycobacterium tuberculosis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O53512 (EMBL:AL021957) (462 aa), Fasta scores: E(): 0, 89.7% identity in 465 aa overlap; and similar to many plant DAHP synthetase family proteins e.g. Arabidopsis thaliana SW:AROF_ARATH (SW:P29976) (525 aa), Fasta scores: E(): 0, 49.0% identity in 441 aa overlap. Identical to the previously sequenced Mycobacterium leprae 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O69569 (EMBL:AL022602) (462 aa), Fasta scores: E(): 0, 100.0% identity in 462 aa overlap. Contains Pfam match to entry PF01474 DAHP_synth_2, Class-II DAHP synthetase family. O69569 No intermediary metabolism and respiration PF01474 O69569 GO:0009073,GO:0003849 Rv2178c Rv2178c AL450380.2 Mycobrowser_v4 CDS 1510443 1511537 . + 0 ML1267 chaA Probable ionic transporter integral membrane protein ChaA ML1267, len: 364 aa. Probable chaA, ionic transporter integral membrane protein, putative calcium/proton antiporter. Highly similar to many antiporters e.g. Mycobacterium tuberculosis Rv1607 TR:O53910 (EMBL:AL022001) (360 aa), Fasta scores: E(): 0, 77.7% identity in 364 aa overlap and Escherichia coli SW:CHAA_ECOLI (P31801) (366 aa), Fasta scores: E(): 0, 36.5% identity in 356 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q7AQ77 No cell wall and cell processes PF01699 Q7AQ77 GO:0016021 Rv1607 Rv1607 AL450380.2 Mycobrowser_v4 CDS 902906 903093 . - 0 ML0759A ML0759A hypothetical protein(pseudogene) ML0759A, len:187. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-17 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1971857 1972192 . + 0 ML1636A ML1636A hypothetical protein(pseudogene) ML1636A, len:335. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-43 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1335155 1336051 . + 0 ML1144 atpG PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG ML1144, len: 298 aa. Probable atpG, ATP synthase [gamma] chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase gamma chain (EC 3.6.1.34) SW:ATPG_MYCLE (P45824) (298 aa), Fasta scores: E(): 0, 100.0% identity in 298 aa overlap. Also highly similar to many other proposed ATPase gamma chain family proteins e.g. Mycobacterium tuberculosis Rv1309 SW:ATPG_MYCTU (Q10597) (305 aa), Fasta scores: E(): 0, 83.9% identity in 305 aa overlap and Streptomyces lividans SW:ATPG_STRLI (P50007) (302 aa), Fasta scores: E(): 0, 48.2% identity in 301 aa overlap. Contains Pfam match to entry PF00231 ATP-synt, ATP synthase. Contains PS00153 ATP synthase gamma subunit signature. P45824 No intermediary metabolism and respiration PF00231 P45824 GO:0046933,GO:0042777,GO:0045261,GO:0046961,GO:0005524 Rv1309 Rv1309 AL450380.2 Mycobrowser_v4 CDS 1438600 1439910 . + 0 ML1216 bioA PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA ML1216, len: 436 aa. Probable bioA, adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62). Identical to the previously sequenced Mycobacterium leprae adenosylmethionine-8-amino-7-oxononanoate SW:BIOA_MYCLE (P45488) (436 aa), Fasta scores: E(): 0, 100.0% identity in 436 aa overlap. Also highly similar to other proteins which have been shown to be involved in the biosynthesis of biotin e.g. Escherichia coli SW:BIOA_ECOLI (P12995) (429 aa), Fasta scores: E(): 0, 50.0% identity in 418 aa overlap BioA and Mycobacterium tuberculosis Rv1568 SW:BIOA_MYCTU (O06622) (437 aa), Fasta scores: E(): 0, 85.1% identity in 436 aa overlap, BioA. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. P45488 No intermediary metabolism and respiration PF00202 P45488 GO:0009102,GO:0030170,GO:0004015 2.6.1.62 Rv1568 Rv1568 AL450380.2 Mycobrowser_v4 CDS 2438066 2438367 . + 0 ML2048A ML2048A hypothetical protein(pseudogene) ML2048A, len:301. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-14 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1000554 1001789 . + 0 ML0842 csd1 Probable cysteine desulfurase 1 Csd1 ML0842, len: 411 aa. csd1, probable cysteine desulfurase 1 (EC 4.4.1.-). Highly similar to the carboxy region of Q9KII6|CSD_MYCPA Probable cysteine desulfurase from Mycobacterium paratuberculosis (685 aa), fasta scores: E(): 8.7e-152, (85.086% identity in 409 aa overlap); and similar to Rv1464|MTV007.11|O53155|AL021184 csd probable cysteine desulfurase from Mycobacterium tuberculosis (417 aa), fasta scores: E(): 0, (43.6% identity in 408 aa). Also similar to ML0117, ML0596 and ML1708 from M. leprae. Previously sequenced as O32975|Z98741. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V. Belongs to the class-V of pyridoxal-phosphate-dependent aminotransferases. Csd subfamily. O32975 No intermediary metabolism and respiration PF00266 O32975 GO:0006534,GO:0030170,GO:0031071 2.8.1.7 AL450380.2 Mycobrowser_v4 CDS 1046922 1047530 . - 0 ML0882c ctaE PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE ML0882c, len: 202 aa. Probable ctaE, cytochrome c oxidase polypeptide III (cox3) (EC 1.9.3.1)Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III ctaE or Rv2193 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 0, 90.1% identity in 203 aa. Similar to many e.g. Synechococcus vulcanus cytochrome C oxidase polypeptide III ctaE SW:COX3_SYNVU (P50677) (201 aa) fasta scores: E(): 1.2e-23, 39.0% identity in 200 aa. Previously sequenced as TR:O69582 (EMBL:AL022602). Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III. Belongs to the cytochrome c oxidase subunit 3 family. O69582 No intermediary metabolism and respiration PF00510 O69582 GO:0016021,GO:0006123,GO:0005886,GO:0004129 1.9.3.1 Rv2193 Rv2193 AL450380.2 Mycobrowser_v4 CDS 995673 996356 . - 0 ML0838c cysE PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) ML0838c, len: 227 aa. Probable cysE, serine acetyltransferase (EC 2.3.1.30). Similar to Mycobacterium tuberculosis putative serine acetyltransferase cysE or Rv2335 or MTCY98.0031c TR:P95231 (EMBL:Z83860) (229 aa) fasta scores: E(): 0, 76.4% identity in 229 aa, and to Bacillus subtilis serine acetyltransferase cysE or cysA SW:CYSE_BACSU (Q06750) (217 aa) fasta scores: E(): 0, 47.1% identity in 204 aa. Previously sequenced as TR:O32979 (EMBL:Z98741). Contains 4 Pfam matches to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats). Contains PS00101 Hexapeptide-repeat containing-transferases signature. BELONGS TO THE CYSE/LACA/LPXA/NODL FAMILY OF ACETYLTRANSFERASES. COMPOSED OF MULTIPLE REPEATS OF [LIV]-G-X(4) O32979 No intermediary metabolism and respiration PF00132 O32979 GO:0005737,GO:0009001,GO:0006535 2.3.1.30 Rv2335 Rv2335 AL450380.2 Mycobrowser_v4 CDS 1223703 1224767 . + 0 ML1059 dapE PROBABLE SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE DAPE ML1059, len: 354 aa. Probable dapE, succinyl-diaminopimelate desuccinylase (EC 3.5.1.18). Identical to the previously sequenced Mycobacterium leprae TR:Q49949 (EMBL:U15180) (400 aa), Fasta scores: E(): 0, 100.0% identity in 354 aa overlap. Also highly similar to succinyl-diaminopimelate desuccinylases from Mycobacterium tuberculosis Rv1202 TR:O05303 (EMBL:Z93777) (354 aa), Fasta scores: E(): 0, 86.7% identity in 354 aa overlap and Corynebacterium glutamicum SW:DAPE_CORG (Q59284) (369 aa), Fasta scores: E(): 0, 56.3% identity in 359 aa overlap. Contains Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40. Contains PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. Q9CCB0 No intermediary metabolism and respiration PF01546,PF07687 Q9CCB0 GO:0046983,GO:0006508,GO:0008270,GO:0008237 Rv1202 Rv1202 AL450380.2 Mycobrowser_v4 CDS 1972409 1972524 . + 0 ML1636B ML1636B hypothetical protein(pseudogene) ML1636B, len:115. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1423017 1426550 . + 0 ML1207 dnaE DNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' EXONUCLEASE ACTIVITY. THE ALPHA CHAIN IS THE DNA POLYMERASE [CATALYTIC ACTIVITY : N DEOXYNUCLEOSIDE TRIPHOSPHATE = N DIPHOSPHATE + {DNA}(N)]. PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) ML1207, len: 1177 aa. Probable dnaE1, DNA polymerase III, alpha chain (EC 2.7.7.7). Identical to the previously sequenced Mycobacterium leprae putative DNA polymerase III alpha chain TR:Q9X7F0 (EMBL:AL049478) (1177 aa), Fasta scores: E(): 0, 100.0% identity in 1177 aa overlap. Also highly similar to DNA polymerases from e.g. Mycobacterium tuberculosis Rv1547 SW:DP3A_MYCTU (Q10779) (1184 aa), Fasta scores: E(): 0, 91.2% identity in 1176 aa overlap and Escherichia coli DnaE or PolC SW:DP3A_ECOLI (P10443) (1160 aa), Fasta scores: E(): 0, 36.1% identity in 1193 aa overlap. Contains Pfam match to entry PF02193 POLIIIAc, DNA polymerase alpha chain like domain. BELONGS TO DNA POLYMERASE TYPE-C FAMILY, DNAE SUBFAMILY Q9X7F0 No information pathways PF01336,PF02811,PF07733 Q9X7F0 GO:0003677,GO:0006260,GO:0003887,GO:0005737,GO:0008408 2.7.7.7 Rv1547 Rv1547 AL450380.2 Mycobrowser_v4 CDS 1476554 1477438 . + 0 ML1241 echA12 possible enoyl-CoA hydratase/isomerase EchA12 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) ML1241, len: 294 aa. Possible enoyl-CoA hydratase (EC 4.2.1.17). Highly similar to ECHC_MYCTU|O53163|Rv1472 EchA12 probable enoyl-CoA hydratase from Mycobacterium tuberculosis (285 aa), Fasta scores: E(): 0, (72.0% identity in 271 aa overlap) and CRT_CLOAB|P52046 acetobutylicum 3-hydroxybutyryl-CoA dehydratase from Clostridium (EC 4.2.1.55) (261 aa), Fasta scores: E(): 5.1e-18, (31.1% identity in 264 aa overlap). Also similar to ML1817c a possible pseudogene similar to M. tuberculosis echA12. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. P53526 No lipid metabolism PF00378 P53526 GO:0006631,GO:0004300 4.2.1.17 Rv1472 Rv1472 AL450380.2 Mycobrowser_v4 CDS 1380303 1380590 . - 0 ML1180c esxL2 Putative ESAT-6 like protein EsxL2 (ESAT-6 LIKE PROTEIN 4) ML1180c, len: 95 aa. Probable esxL2, ESAT-6 like protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein Q49946|EMBL:U15180 (95 aa), Fasta scores: E(): 0, (100.0% identity in 95 aa overlap). Identical to ML1056 a possible orthologue of M. tuberculosis esxL1. Also similar to several putative Esat-6 like proteins from M. tuberculosis e.g. O05300|ESXL_MYCTU ESAT-6 like protein esxL (94 aa), Fasta scores: E(): 7.7e-24, (64.130% identity in 92 aa overlap). SEEMS TO BELONG TO THE ESAT6 FAMILY. Q49946 No cell wall and cell processes Q49946 Rv1198 Rv1198 AL450380.2 Mycobrowser_v4 CDS 1631874 1633262 . + 0 ML1372 engA PROBABLE GTP-BINDING PROTEIN ENGA ML1372, len: 462 aa. Probable engA, GTP-binding protein. Highly similar to many proposed Era/ThdF family GTP-binding proteins including: Bacillus subtilis SW:ENGA_BACSU (P50743) (436 aa), Fasta scores: E(): 0, 41.0% identity in 434 aa overlap and Mycobacterium tuberculosis Rv1713 SW:ENGA_MYCTU (O33212) (463 aa), Fasta scores: E(): 0, 88.6% identity in 463 aa overlap. Contains Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Q49884 No intermediary metabolism and respiration PF01926 Q49884 GO:0005622,GO:0005525 Rv1713 Rv1713 AL450380.2 Mycobrowser_v4 CDS 1352915 1354096 . + 0 ML1158 fadA4 PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA4 (ACETOACETYL-CoA THIOLASE) ML1158, len: 393 aa. Probable fadA4, acetyl-CoA C-acetyltransferase (EC 2.3.1.9). Identical to the previously sequenced Mycobacterium leprae probable acetyl-CoA acetyltransferase SW:THIL_MYCLE (P46707) (393 aa), Fasta scores: E(): 0, 100.0% identity in 393 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis (FadA4) Rv1323 SW:THIL_MYCTU (Q10629) (389 aa), Fasta scores: E(): 0, 86.9% identity in 388 aa overlap and acetyl-CoA acetyltransferases from Alcaligenes eutrophus SW:THIL_ALCEU (P14611) (393 aa), Fasta scores: E(): 0, 50.4% identity in 389 aa overlap. Also similar to ML2162 from M. leprae. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00098 Thiolases acyl-enzyme intermediate signature. Contains PS00099 Thiolases active site. Contains PS00737 Thiolases signature 2. P46707 No lipid metabolism PF00108,PF02803 P46707 GO:0008152,GO:0003985 2.3.1.9 AL450380.2 Mycobrowser_v4 CDS 978844 980235 . + 0 ML0826 glyS PROBABLE GLYCYL-tRNA SYNTHETASE GLYS (GLYCINE--tRNA LIGASE) (GLYRS) ML0826, len: 463 aa. Probable glyS, glycyl-tRNA synthetase (EC 6.1.1.14). Similar to Rv2357c|MTCY27.23|MTCY98.26|SYG_MYCTU|O65932 Mycobacterium tuberculosis glycyl-tRNA synthetase glyS (463 aa) fasta scores: E(): 0, 90.2% identity in 459 aa and to SYG_THETH|P56206 Thermus aquaticus glycyl-tRNA synthetase glyS (505 aa) fasta scores: E(): 0, 43.6% identity in 512 aa. Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. Q9CCG4 No information pathways PF00587,PF03129 Q9CCG4 GO:0005524,GO:0005737,GO:0004820,GO:0006426 Rv2357c Rv2357c AL450380.2 Mycobrowser_v4 CDS 1506035 1506772 . + 0 ML1261 hisA histidine biosynthesis pathway (fourth step) [CATALYTIC ACTIVITY : 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide = 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide..] PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE HISA (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) ML1261, len: 245 aa. Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16). Highly similar to many phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerases involved in histidine biosynthesis including: Mycobacterium tuberculosis Rv1603 SW:HIS4_MYCT (O0658) (245 aa), Fasta scores: E(): 0, 84.4% identity in 244 aa overlap and Streptomyces coelicolor SW:HIS4_STRCO (P16250) (240 aa), Fasta scores: E(): 0, 66.3% identity in 240 aa overlap. Contains Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein. Belongs to the hisA / hisF family. Q9CC56 No intermediary metabolism and respiration PF00977 Q9CC56 GO:0005737,GO:0000105,GO:0004640,GO:0000162,GO:0003949 5.3.1.24,5.3.1.16 Rv1603 Rv1603 AL450380.2 Mycobrowser_v4 CDS 1326904 1327770 . + 0 ML1135 hemK PROBABLE PROTOPORHYRINOGEN OXIDASE HEMK HOMOLOG ML1135, len: 288 aa. Probable hemK, protoporphyrinogen oxidase. Highly similar to numerous members of the HemK family of modification methylases such as Mycobacterium tuberculosis, Rv1300, SW:HEMK_MYCTU (Q10602) (325 aa), Fasta scores: E(): 0, 73.9% identity in 284 aa overlap and Escherichia coli SW:HEMK_ECOLI (P37186) (277 aa), Fasta scores: E(): 2.4e-17, 32.5% identity in 277 aa overlap. P45832 No intermediary metabolism and respiration PF08241 P45832 GO:0008276,GO:0006479 2.1.1.- Rv1300 Rv1300 AL450380.2 Mycobrowser_v4 CDS 2483062 2483178 . + 0 ML2088A ML2088A hypothetical protein(pseudogene) ML2088A, len:116. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1467578 1469317 . - 0 ML1234c fadD21 PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) ML1234c, len: 579 aa. Probable fadD21, fatty-acid-CoA synthetase (EC 6.2.1.-). Highly similar to acyl-CoA synthases from Mycobacterium tuberculosis Rv1185c TR:O50441 (EMBL:AL010186) (578 aa), Fasta scores: E(): 0, 72.4% identity in 579 aa overlap and Mycobacterium bovis TR:P71495 (EMBL:U7568) (582 aa), Fasta scores: E(): 0, 63.4% identity in 579 aa overlap. Also similar to ML0100, ML0132, ML0138, ML0243 and ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. P54200 No lipid metabolism PF00501 P54200 GO:0016874,GO:0006631 6.2.1.- Rv1185c Rv1185c AL450380.2 Mycobrowser_v4 CDS 1217112 1218542 . + 0 ML1051 fadD36 PROBABLE FATTY-ACID-CoA LIGASE FADD36 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) ML1051, len: 476 aa. Probable fadD36, fatty-acid-CoA synthetase (EC 6.2.1.-). Identical to the previously sequenced Mycobacterium leprae XclC TR:Q50017 (EMBL:U15181) (476 aa), Fasta scores: E(): 0, 99.8% identity in 476 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis fatty-acid-CoA synthetase Rv1193 fadD36 TR:O05295 (EMBL:Z93777) (473 aa), Fasta scores: E(): 0, 81.3% identity in 476 aa overlap and Escherichia coli long-chain-fatty-acid--coa ligase (EC 6.2.1.3) SW:LCFA_ECOLI (P29212) (561 aa), Fasta scores: E(): 1.3e-28, 31.7% identity in 378 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Note previously known as xclC Q50017 No lipid metabolism PF00501 Q50017 GO:0008152,GO:0003824 Rv1193 Rv1193 AL450380.2 Mycobrowser_v4 CDS 1144499 1147159 . + 0 ML0977 ftsK POSSIBLE CELL DIVISION TRANSMEMBRANE PROTEIN FTSK ML0977, len: 886 aa. Probable Cell division transmembrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05560 (EMBL:Z94723) (886 aa), Fasta scores: E(): 0, 100.0% identity in 886 aa overlap. Also highly similar to many proteins involved in cell division e.g. Escherichia coli SW:FTSK_ECOLI (P46889) (1329 aa), Fasta scores: E(): 0, 43.9% identity in 531 aa overlap and Mycobacterium tuberculosis Rv2748c TR:O33290 (EMBL:AL008967) (883 aa), Fasta scores: E(): 0, 78.1% identity in 885 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FTSK/SPOIIIE FAMILY. O05560 No cell wall and cell processes PF01580,PF09397 O05560 GO:0003677,GO:0007049,GO:0051301,GO:0007059,GO:0016021,GO:0017111,GO:0005886,GO:0005524 Rv2748c Rv2748c AL450380.2 Mycobrowser_v4 CDS 1999765 1999887 . - 0 ML1657A ML1657A hypothetical protein(pseudogene) ML1657A, len:122. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-07 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1240775 1242376 . + 0 ML1078 htrA PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN) ML1078, len: 533 aa. Probable htrA, serine protease (EC 3.4.21.-). Identical to the previously sequenced Mycobacterium leprae TR:Q49972 (EMBL:U15180) (533 aa), Fasta scores: E(): 0, 99.8% identity in 533 aa overlap. Also highly similar to Mycobacterium tuberculosis possible serine protease HtrA Rv1223 TR:O06291 (EMBL:Z98260) (528 aa), Fasta scores: E(): 0, 81.8% identity in 533 aa overlap. The C-terminus of this CDS is similar to several proven proteases e.g. Escherichia coli SW:HTRA_ECOLI (P09376) (474 aa), Fasta scores: E(): 2e-26, 35.3% identity in 283 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains Pfam match to entry PF00089 trypsin, Trypsin. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q49972 No intermediary metabolism and respiration PF00089 Q49972 GO:0006508,GO:0004252,GO:0005515 Rv1223 Rv1223 AL450380.2 Mycobrowser_v4 CDS 963831 964517 . - 0 ML0815c ML0815c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) ML0815c, len: 228 aa. Probable transcriptional regulator, TetR family. Similar to Rv3208|MTCY07D11.18c|O05858|Z95120 Mycobacterium tuberculosis putative TetR-family transcriptional regulator (228 aa) fasta scores: E(): 0, (82.4% identity in 227 aa). Contains a probable helix-turn-helix motif at aa 60-81 (Score 1517, SD +4.35) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Q9CCH0 No regulatory proteins PF00440 Q9CCH0 GO:0003700,GO:0006355 Rv3208 Rv3208 AL450380.2 Mycobrowser_v4 CDS 1021413 1022120 . - 0 ML0859c lipB Probable lipoate biosynthesis protein B LipB ML0859c, len: 235 aa. Probable lipB, lipoate-protein ligase B (EC. 6.-.-.-). Similar to Mycobacterium tuberculosis lipoate-protein ligase B lipB or Rv2217 or MTCY190.28 SW:LIPB_MYCTU (Q10404) (230 aa) fasta scores: E(): 0, 78.4% identity in 218 aa. Similar to Escherichia coli lipoate-protein ligase B lipB SW:LIPB_ECOLI (P30976) (191 aa) blastp scores:: 84.1 bits, 55% identity in 163 aa. Previously sequenced as SW:LIPB_MYCLE (O32961). Contains Pfam match to entry PF02111 Lipoate_B, Lipoate-protein ligase B. Contains PS01313 Lipoate-protein ligase B signature. O32961 No intermediary metabolism and respiration PF03099 O32961 GO:0005737,GO:0009107,GO:0033819,GO:0006464,GO:0008415 2.3.1.181 Rv2217 Rv2217 AL450380.2 Mycobrowser_v4 CDS 1068514 1069233 . - 0 ML0902c lppM probable conserved lipoprotein LppM ML0902c, len: 239 aa. Probable lppM, conserved lipoprotein. Identical to the previously sequenced Mycobacterium leprae putative lipoprotein TR:O69564 (EMBL:AL022602) (239 aa), Fasta scores: E(): 0, 99.6% identity in 239 aa overlap and also highly similar to another putative lipoprotein from Mycobacterium tuberculosis TR:O53505 (EMBL:AL021957) (227 aa), Fasta scores: E(): 0, 75.4% identity in 224 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7AQC9 No cell wall and cell processes Q7AQC9 Rv2171 Rv2171 AL450380.2 Mycobrowser_v4 CDS 1234640 1235293 . + 0 ML1070 ML1070 possible TetR-family transcriptional regulatory protein ML1070, len: 217 aa. Possible TetR-family transcriptional regulatory protein. Identical to the previously sequenced Mycobacterium leprae Q49962|U15180 (217 aa), Fasta scores: E(): 0, (100.0% identity in 217 aa overlap). Also similar to many transcriptional regulatory proteins and appears to be a paralogue of Rv3855|P96222|Z83864 ethR regulatory protein tetR family from M. tuberculosis (216 aa), Fasta scores: E(): 0, (60.4% identity in 202 aa overlap). Also similar to ML0064 ethR regulatory protein from M. leprae. Contains a probable helix-turn-helix motif at aa 49-70 (Score 1321, SD +3.69). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Q7AQ94 No regulatory proteins PF00440 Q7AQ94 GO:0006355,GO:0016566,GO:0003700,GO:0016481 AL450380.2 Mycobrowser_v4 CDS 1248328 1249734 . + 0 ML1086 lpqY PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY ML1086, len: 468 aa. Probable lpqY, sugar-binding lipoprotein component of sugar transport system. Previously sequenced Mycobacterium leprae TR:Q49975 (EMBL:U15180) (469 aa), Fasta scores: E(): 0, 100.0% identity in 468 aa overlap. Also similar to many solute-binding transport proteins e.g. from Mycobacterium tuberculosis Rv1235 TR:O31095 (EMBL:AF028830) (468 aa), Fasta scores: E(): 0, 77.6% identity in 469 aa overlap and Escherichia coli SW:MALE_ECOLI (P02928) (396 aa), Fasta scores: E(): 0.00081, 23.4% identity in 295 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CCA3 No cell wall and cell processes PF01547 Q9CCA3 GO:0005215,GO:0006810 Rv1235 Rv1235 AL450380.2 Mycobrowser_v4 CDS 1291566 1292132 . + 0 ML1115 lprB POSSIBLE LIPOPROTEIN LPRB ML1115, len: 188 aa. Possible lprB, lipoprotein. Highly similar to Mycobacterium tuberculosis possible lipoprotein Rv1274 SW:LPRB_MYCTU (Q11045) (185 aa), Fasta scores: E(): 0, 78.2% identity in 188 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CC87 No cell wall and cell processes Q9CC87 GO:0005886 Rv1274 Rv1274 AL450380.2 Mycobrowser_v4 CDS 1318223 1319641 . + 0 ML1128 lysA PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) ML1128, len: 472 aa. Probable lysA, diaminopimelate decarboxylase (EC 4.1.1.20). Previously sequenced Mycobacterium leprae Q50140|U15186 (495 aa), Fasta scores: E(): 0, 100.0% identity in 472 aa overlap. Highly similar to many diaminopimelate decarboxylases (EC 4.1.1.20) involved in the last step of lysine biosynthesis e.g. DCDA_MYCTU|P31848 Rv1293 LysA from Mycobacterium tuberculosis (447 aa), Fasta scores: E(): 0, (86.8% identity in 446 aa overlap). Also similar to ML0251c a possible pseudogene similar to M. tuberculosis lysA. Contains Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R). Contains Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase. Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. Q50140 No intermediary metabolism and respiration PF00278,PF02784 Q50140 GO:0009089,GO:0008836 4.1.1.20 Rv1293 Rv1293 AL450380.2 Mycobrowser_v4 CDS 1621827 1623008 . + 0 ML1361 ML1361 conserved membrane protein ML1361, len: 393 aa. Conserved membrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa), Fasta scores: E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain at the C-terminal end. Q9CC30 No cell wall and cell processes, conserved hypotheticals Q9CC30 GO:0009229,GO:0004788,GO:0005524 Rv1697 Rv1697 AL450380.2 Mycobrowser_v4 CDS 1259135 1259968 . - 0 ML1094c ML1094c ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE ML1094c, len: 277 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-). Highly similar to several Mycobacterium tuberculosis putative oxidoreductases e.g. Rv1245c TR:O50460 (EMBL:AL021006) (276 aa), Fasta scores: E(): 0, 78.3% identity in 277 aa overlap. Also similar to many others including: Pseudomonas paucimobilis SW:LINX_PSEPA (P50198) (250 aa), Fasta scores: E(): 9.3e-17, 35.6% identity in 194 aa overlap 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Q9CC98 No intermediary metabolism and respiration PF00106 Q9CC98 GO:0005488,GO:0008152,GO:0016491 Rv1245 Rv1245 AL450380.2 Mycobrowser_v4 CDS 1058708 1059994 . - 0 ML0893c ML0893c probable conserved integral membrane protein ML0893c, len: 428 aa. Probable conserved integral membrane protein. Identical to the previously sequenced Mycobacterium leprae putative integral membrane protein TR:O69571 (EMBL:AL022602) (428 aa), Fasta scores: E(): 0, 100.0% identity in 428 aa overlap. Also highly similar to Mycobacterium tuberculosis putative membrane protein Rv2181 TR:O53515 (EMBL:AL021957) (427 aa), Fasta scores: E(): 0, 80.0% identity in 431 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Q7AQD6 No cell wall and cell processes PF09594 Q7AQD6 Rv2181 Rv2181 AL450380.2 Mycobrowser_v4 CDS 1070254 1070658 . + 0 ML0904 ML0904 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML0904, len: 134 aa. Probable conserved membrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69562 (EMBL:AL022602) (134 aa), Fasta scores: E(): 0, 100.0% identity in 134 aa overlap. Also highly similar to several others e.g. Mycobacterium tuberculosis hypothetical protein Rv2169c TR:O53503 (EMBL:AL021957) (134 aa), Fasta scores: E(): 0, 86.6% identity in 134 aa overlap and Streptomyces coelicolor putative membrane protein TR:Q9XAJ8 (EMBL:AL079348) (96 aa), Fasta scores: E(): 0.22, 38.3% identity in 60 aa overlap. Contains a large central possible membrane spanning hydrophobic domain. Q7AQC7 No cell wall and cell processes Q7AQC7 Rv2169c Rv2169c AL450380.2 Mycobrowser_v4 CDS 1147778 1148359 . + 0 ML0979 pgsA3 PROBABLE PGP SYNTHASE PGSA3 (CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3- PHOSPHATIDYLTRANSFERASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) ML0979, len: 193 aa. Probable pgsA3, PGP synthase (EC 2.7.8.5). Identical to the previously sequenced Mycobacterium leprae TR:Q49839 (EMBL:U00019) (193 aa), Fasta scores: E(): 0, 100.0% identity in 193 aa overlap. Also highly similar to many phosphatidylglycerophosphate synthases including: Mycobacterium tuberculosis Rv2746c TR:O33288 (EMBL:AL008967) (209 aa), Fasta scores: E(): 0, 77.1% identity in 188 aa overlap and Bacillus subtilis SW:PGSA_BACSU (P46322) (193 aa), Fasta scores: E(): 5.6e-17, 35.8% identity in 193 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. Q7AQC0 No lipid metabolism PF01066 Q7AQC0 GO:0016021,GO:0008654,GO:0008444 Rv2746c Rv2746c AL450380.2 Mycobrowser_v4 CDS 1840478 1840960 . - 0 ML1526c ML1526c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML1526c, len: 160 aa. Probable conserved transmembrane protein. Highly similar to many proteins of undefined function e.g. Mycobacterium tuberculosis Rv2772c TR:O33314 (EMBL:AL008967) (157 aa), Fasta scores: E(): 0, 76.6% identity in 154 aa overlap. Contains possible membrane spanning hydrophobic domains. Q9CBV7 No cell wall and cell processes PF07719 Q9CBV7 Rv2772c Rv2772c AL450380.2 Mycobrowser_v4 CDS 1612179 1613459 . + 0 ML1352 tyrS Probable Tyrosyl-tRNA synthase TyrS (TYRRS) ML1352, len: 426 aa. Probable Tyrosyl-tRNA synthase (EC 6.1.1.1). Highly similar to many tyrosyl-tRNA synthetases including: Bacillus stearothermophilus SW:SYY_BACST (P00952) (419 aa), Fasta scores: E(): 0, 50.2% identity in 416 aa overlap and Mycobacterium tuberculosis Rv1689 SW:SYY_MYCTU (O33191) (424 aa), Fasta scores: E(): 0, 83.6% identity in 426 aa overlap. Contains Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Q49900 No information pathways PF00579,PF01479 Q49900 GO:0003723,GO:0005737,GO:0004831,GO:0006437,GO:0005524 6.1.1.1 Rv1689 Rv1689 AL450380.2 Mycobrowser_v4 CDS 1630439 1631212 . + 0 ML1370 ML1370 Hypothetical pseudouridine synthase (Uracil hydrolyase) ML1370, len: 257 aa. Hypothetical pseudouridine synthase (EC 4.2.1.70). Highly similar to several pseudouridylate synthases involved in the modification of ribosomal RNA e.g. Bacillus subtilis ribosomal large subunit pseudouridine synthase B SW:RLUB_BACSU (P35159) (229 aa), Fasta scores: E(): 3.6e-30, 42.8% identity in 229 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv1711 SW:YH11_MYCTU (O33210) (254 aa), Fasta scores: E(): 0, 80.2% identity in 257 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain. Contains Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase. Contains PS01149 Rsu family of pseudouridine synthase signature. Belongs to the pseudouridine synthase rsuA family. O05668 No information pathways, conserved hypotheticals PF00849,PF01479 O05668 GO:0009982,GO:0001522,GO:0003723 5.4.99.- Rv1711 Rv1711 AL450380.2 Mycobrowser_v4 CDS 1486028 1488355 . + 0 ML1246 plsB PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE PLSB2 (GPAT) ML1246, len: 775 aa. Probable plsB2, glycerol-3-phosphate acyltransferase (EC 2.3.1.15). Highly similar to many acyltransferases including: Escherichia coli glycerol-3-phosphate acyltransferase (EC 2.3.1.15) SW:PLSB_ECOLI (P00482) (806 aa), Fasta scores: E(): 1.5e-27, 24.4% identity in 693 aa overlap and Mycobacterium tuberculosis putative acyltransferase PlsB2 Rv2482c SW:PLS2_MYCTU (O53207) (789 aa), Fasta scores: E(): 0, 80.7% identity in 783 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. Q9X7B0 No lipid metabolism PF01553 Q9X7B0 GO:0008654,GO:0005886,GO:0004366 2.3.1.15 Rv2482c Rv2482c AL450380.2 Mycobrowser_v4 CDS 983360 983422 . + 0 ML0828A ML0828A hypothetical protein(pseudogene) ML0828A, len:62. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.006 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1123020 1124825 . - 0 ML0955c ppdK PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK ML0955c, len: 601 aa. Probable ppdK, pyruvate, phosphate dikinase (EC 2.7.9.1). Identical to the previously sequenced Mycobacterium leprae pyruvate, phosphate dikinase TR:O05566 (EMBL:Z94723) (601 aa), Fasta scores: E(): 0, 99.8% identity in 601 aa overlap. Also highly similar to pyruvate, phosphate dikinases from Mycobacterium tuberculosis Rv1127c TR:O06579 (EMBL:Z95585) (490 aa), Fasta scores: E(): 0, 71.8% identity in 478 aa overlap and Clostridium symbiosumSW:PODK_CLOSY (P22983) (873 aa), Fasta scores: E(): 0, 35.2% identity in 537 aa overlap. Contains Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzymes. Contains Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain. O05566 No intermediary metabolism and respiration PF00391,PF01326 O05566 GO:0016301,GO:0016310,GO:0005524 Rv1127c Rv1127c AL450380.2 Mycobrowser_v4 CDS 1381007 1382272 . - 0 ML1182c PPE PPE-family protein ML1182c, len: 421 aa. Member of the PPE protein family. Identical to the previously sequenced Mycobacterium leprae putative PPE protein TR:Q9Z5K0 (EMBL:AL049191) (421 aa), Fasta scores: E(): 0, 100.0% identity in 421 aa overlap. Also highly similar to many members of the Mycobacterium tuberculosis PPE-family of proteins e.g. O05298 Rv1196 (391 aa), fasta scores: E(): 3e-23, (41.135% identity in 423 aa overlap) and Rv2892c SW:YS92_MYCTU (Q10813) (408 aa), Fasta scores: E(): 1.2e-25, 34.0% identity in 429 aa overlap. Also similar to ML1054 a possible pseudogene similar to M. tuberculosis Rv1196. Contains Pfam match to entry PF00823 PPE, PPE family. Q7AQ89 No PE/PPE PF00823 Q7AQ89 Rv1196 Rv1196 AL450380.2 Mycobrowser_v4 CDS 1190923 1191897 . - 0 ML1023c ppgK probable polyphosphate glucokinase PpgK (POLYPHOSPHATE-GLUCOSE PHOSPHOTRANSFERASE) ML1023c, len: 324 aa. Probable ppgK, polyphosphate glucokinase (EC 2.7.1.63). Identical to the previously sequenced Mycobacterium leprae polyphosphate glucokinase (EC 2.7.1.63) SW:PPGK_MYCLE (Q49988) (324 aa), Fasta scores: E(): 0, 99.7% identity in 324 aa overlap catalysing the phosphorylation of glucose thereby generating D-glucose 6-phosphate. Also highly similar to Mycobacterium tuberculosis Rv2702 SW:PPGK_MYCTU (Q59568) (265 aa), Fasta scores: E(): 0, 82.8% identity in 262 aa overlap. Note the predicted translational start site for this CDS maybe incorrect due to the overlap with CDS ML1024. Q49988 No intermediary metabolism and respiration PF00480 Q49988 GO:0005737,GO:0047330,GO:0005524 2.7.1.63 Rv2702 Rv2702 AL450380.2 Mycobrowser_v4 CDS 1566115 1566960 . + 0 ML1313 ML1313 POSSIBLE RNA METHYLTRANSFERASE ML1313, len: 281 aa. Possible RNA methyltransferase (EC 2.1.1.-). Highly similar to several proteins of unknown function and Mycobacterium tuberculosis Rv2118c TR:O33253 (EMBL:Z97559) Possible RNA methyltransferase (280 aa), Fasta scores: E(): 0, 84.0% identity in 281 aa overlap. Q7AQ71 No intermediary metabolism and respiration PF08704 Q7AQ71 GO:0030488,GO:0016429 Rv2118c Rv2118c AL450380.2 Mycobrowser_v4 CDS 1556855 1560475 . + 0 ML1307 metH Probable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS) ML1307, len: 1206 aa. Probable 5-methyltetrahydrofolate--homocystein methyltransferase (EC 2.1.1.13). Highly similar to many 5-methyltetrahydrofolate--homocysteine methyltransferases involved in methionine biosynthesis, including: Escherichia coli MetH SW:METH_ECOLI (P13009) (1226 aa), Fasta scores: E(): 0, 31.6% identity in 1233 aa overlap and Mycobacterium tuberculosis Rv2124c SW:METH_MYCTU (O33259) (1192 aa), Fasta scores: E(): 0, 88.3% identity in 1204 aa overlap. Q49775 No intermediary metabolism and respiration PF00809,PF02310,PF02574,PF02607,PF02965 Q49775 GO:0050897,GO:0004156,GO:0009396,GO:0008898,GO:0005622,GO:0009086,GO:0008705,GO:0008270,GO:0031419 2.1.1.13 Rv2124c Rv2124c AL450380.2 Mycobrowser_v4 CDS 1999885 1999932 . + 0 ML1657B ML1657B hypothetical protein(pseudogene) ML1657B, len:47. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-03 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1328503 1329702 . + 0 ML1137 rfe PROBABLE UNDECAPAPRENYL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMINYLTRANSFERASE RFE (UDP-GlcNAc TRANSFERASE) ML1137, len: 399 aa. Probable rfe, undecaprenyl-phosphatealpha-N-acetylglucosaminyltransferase (EC 2.4.1.-). Previously sequenced Mycobacterium leprae SW:RFE_MYCLE (P45830) (398 aa), Fasta scores: E(): 0, 99.7% identity in 398 aa overlap. Similar to many including: Mycobacterium tuberculosis putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase SW:RFE_MYCTU (Q10606) (404 aa), Fasta scores: E(): 0, 89.2% identity in 398 aa overlap and Bacillus subtilis phospho-N-acetylmuramoyl-pentapeptide-transferase SW:MRAY_BACSU (Q03521) (324 aa), Fasta scores: E(): 1.9e-07, 28.6% identity in 297 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase. P45830 No cell wall and cell processes PF00953 P45830 GO:0009103,GO:0000287,GO:0030145,GO:0008963,GO:0005886,GO:0016757,GO:0016021 2.7.8.- Rv1302 Rv1302 AL450380.2 Mycobrowser_v4 CDS 1325477 1325731 . + 0 ML1133 rpmE PROBABLE 50S RIBOSOMAL PROTEIN L31 RPME ML1133, len: 84 aa. Probable rpmE, 50S ribosomal protein L31. Identical to the previously sequenced Mycobacterium leprae 50s ribosomal protein L31 SW:RL31_MYCLE (P45834) (84 aa), Fasta scores: E(): 0, 100.0% identity in 84 aa overlap, as well as being highly similar to many others e.g. Mycobacterium tuberculosis Rv1298 SW:RL31_MYCTU (Q10608) (80 aa), Fasta scores: E(): 5.8e-27, 89.6% identity in 77 aa overlap and Escherichia coli SW:RL31_ECOLI (P02432) (70 aa), Fasta scores: E(): 3.4e-11, 53.8% identity in 65 aa overlap. Contains Pfam match to entry PF01197 Ribosomal_L31, Ribosomal protein L31. Contains PS00190 Cytochrome c family heme-binding site signature. Contains PS01143 Ribosomal protein L31 signature. P45834 No information pathways PF01197 P45834 GO:0005840,GO:0003735,GO:0006412,GO:0008270,GO:0019843 Rv1298 Rv1298 AL450380.2 Mycobrowser_v4 CDS 1251535 1252713 . + 0 ML1089 sugC PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC ML1089, len: 392 aa. Probable sugC, sugar-transport ATP-binding protein ABC transporter. Identical to the previously sequenced Mycobacterium leprae TR:Q49978 (EMBL:U15180) (392 aa), Fasta scores: E(): 0, 100.0% identity in 392 aa overlap. Also highly similar to many ABC-transport proteins including: Mycobacterium tuberculosis Rv1238 TR:O50454 (EMBL:AL021006) (393 aa), Fasta scores: E(): 0, 79.9% identity in 389 aa overlap and Agrobacterium radiobacter SW:LACK_AGRRD (Q01937) (363 aa), Fasta scores: E(): 0, 53.1% identity in 339 aa overlap lactose transport ATP-binding protein. Also similar to ML1424 from M. leprae. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q7AQ92 No cell wall and cell processes PF00005 Q7AQ92 GO:0043190,GO:0016887,GO:0016820,GO:0006810,GO:0005215,GO:0005524 Rv1238 Rv1238 AL450380.2 Mycobrowser_v4 CDS 1833030 1833830 . - 0 ML1519c thyA PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) ML1519c, len: 266 aa. Probable thyA, thymidylate synthase (EC 2.1.1.45). Highly similar to many thymidylate synthases involved in deoxyribonucleotide biosynthesis including: Escherichia coli SW:TYSY_ECOLI (P00470) (264 aa), Fasta scores: E(): 0, 66.3% identity in 261 aa overlap and Mycobacterium tuberculosis Rv2764c SW:TYSY_MYCTU (O33306) (263 aa), Fasta scores: E(): 0, 85.5% identity in 262 aa overlap. Contains Pfam match to entry PF00303 thymidylat_synt, Thymidylate synthase. Contains PS00091 Thymidylate synthase active site. Q9CBW0 No intermediary metabolism and respiration PF00303 Q9CBW0 GO:0006231,GO:0004799,GO:0005737 2.1.1.45 Rv2764c Rv2764c AL450380.2 Mycobrowser_v4 CDS 1546965 1547717 . + 0 ML1298 ML1298 conserved hypothetical protein ML1298, len: 250 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2135c TR:O06240 (EMBL:Z95388) (236 aa), Fasta scores: E(): 0, 75.2% identity in 250 aa overlap. Also similar, in regions, to several putative phosphoglycerate mutases e.g. Escherichia coli SW:PMG2_ECOLI (P36942) (215 aa), Fasta scores: E(): 1.2e-06, 27.1% identity in 192 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Q9CC41 No conserved hypotheticals PF00300 Q9CC41 Rv2135c Rv2135c AL450380.2 Mycobrowser_v4 CDS 1567376 1567960 . - 0 ML1315c lppK Probable conserved lipoprotein LppK ML1315c, len: 194 aa. Probable lppK, conserved lipoprotein. Highly similar to Mycobacterium tuberculosis putative lipoprotein LppK (Rv2116) SW:LPPK_MYCTU (O33251) (189 aa), Fasta scores: E(): 1.4e-29, 51.6% identity in 188 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q49803 No cell wall and cell processes Q49803 GO:0005886 Rv2116 Rv2116 AL450380.2 Mycobrowser_v4 CDS 1575685 1576560 . + 0 ML1322 prcB proteasome (beta subunit) PrcB ML1322, len: 291 aa. Probable prcB, proteasome beta-type subunit 2 (EC 3.4.25.1). Highly similar to many proposed 20S proteasome beta subunits including: Methanococcus jannaschii SW:PRCB_METJA (Q58634) (224 aa), Fasta scores: E(): 0.00015, 29.0% identity in 183 aa overlap, Rhodococcus sp. TR:Q53079 (EMBL:U26421) (294 aa), Fasta scores: E(): 0, 63.5% identity in 266 aa overlap and Mycobacterium tuberculosis Rv2110c TR:O33245 (EMBL:Z97559) (291 aa), Fasta scores: E(): 0, 81.0% identity in 290 aa overlap. Contains Pfam match to entry PF00227 proteasome, Proteasome A-type and B-type. Q49780 No intermediary metabolism and respiration PF00227 Q49780 GO:0005839,GO:0004298,GO:0006511,GO:0005829 Rv2110c Rv2110c AL450380.2 Mycobrowser_v4 CDS 1667053 1667496 . + 0 ML1390 ML1390 IRON-REGULATED CONSERVED HYPOTHETICAL PROTEIN TB15.3 HOMOLOG ML1390, len: 147 aa. Possible iron-regulated conserved hypothetical protein TB15.3 homolog. Highly similar to Mycobacterium tuberculosis Rv1636 TR:O06153 (EMBL:Z95554) TB15.3 iron-regulated conserved hypothetical protein (146 aa), Fasta scores: E(): 0, 89.0% identity in 146 aa overlap and Neisseria meningitidis TR:AAF41856 (EMBL:AE002499) Hypothetical protein (154 aa), Fasta scores: E(): 1.7e-07, 32.4% identity in 148 aa overlap. Contains Pfam match to entry PF00582 Usp, Universal stress protein family. Q9CC26 No conserved hypotheticals, virulence, detoxification, adaptation PF00582 Q9CC26 GO:0006950 Rv1636 Rv1636 AL450380.2 Mycobrowser_v4 CDS 1667505 1668203 . - 0 ML1391c ML1391c conserved hypothetical protein ML1391c, len: 232 aa. Conserved hypothetical protein. Similar to several including: Streptomyces coelicolor putative hydrolase TR:Q9Z505 (EMBL:AL035591) (218 aa), Fasta scores: E(): 0, 50.9% identity in 224 aa overlap and in parts to Rhodopseudomonas blastica probable hydroxyacylglutathione hydrolase SW:GLO2_RHOBL (P05446) (255 aa), Fasta scores: E(): 2.4e-08, 37.9% identity in 145 aa overlap. Also similar to Mycobacterium tuberculosis hypothetical protein Rv1637c TR:O06154 (EMBL:Z95554) (264 aa), Fasta scores: E(): 0, 84.0% identity in 231 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Q9CC25 No conserved hypotheticals PF00753 Q9CC25 GO:0016787 Rv1637c Rv1637c AL450380.2 Mycobrowser_v4 CDS 1671927 1675046 . - 0 ML1393c lysX Possible lysyl-tRNA synthetase 2 LysX ML1393c, len: 1039 aa. Possible lysX, lysyl-tRNA synthetase 2 (EC 6.1.1.6). Similar to Mycobacterium tuberculosis Rv1640c TR:P94974 (EMBL:Z85982) (1172 aa), Fasta scores: E(): 0, 82.0% identity in 1041 aa overlap and Q825Z7 Putative lysyl-tRNA synthetase from Streptomyces avermitilis (1093 aa), fasta scores: E(): 2.3e-176, (55.673% identity in 1040 aa overlap). The C-terminal region of the predicted product of this CDS is highly similar to many other lysyl-tRNA synthetases including Haemophilus influenzae SW:SYK_HAEIN (P43825) (502 aa), Fasta scores: E(): 0, 40.1% identity in 504 aa overlap. The N-terminus is similar to several proposed membrane proteins e.g. Streptomyces coelicolor TR:O69916 (EMBL:AL023861) (589 aa), Fasta scores: E(): 0, 47.8% identity in 510 aa overlap. Also similar to ML0233 from M. leprae. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Q9CC23 No information pathways PF00152,PF01336,PF04329,PF04330,PF04331 Q9CC23 GO:0005737,GO:0004824,GO:0006430,GO:0000287,GO:0003676,GO:0005524 6.1.1.6 Rv1640c Rv1640c AL450380.2 Mycobrowser_v4 CDS 1676419 1676613 . + 0 ML1395 rpmI Probable 50S ribosomal protein L35 RpmI ML1395, len: 64 aa. Probable rpmI, 50S ribosomal protein L35. Highly similar to many 50s ribosomal L35 proteins, including: Escherichia coli SW:RL35_ECOLI (P07085) (64 aa), Fasta scores: E(): 2.3e-05, 43.4% identity in 53 aa overlap and Mycobacterium tuberculosis Rv1642 SW:RL35_MYCTU (P94976) (64 aa), Fasta scores: E(): 1.6e-24, 90.6% identity in 64 aa overlap. Contains Pfam match to entry PF01632 Ribosomal_L35p, Ribosomal protein L35. Belongs to the L35P family of ribosomal proteins. Q9CC21 No information pathways PF01632 Q9CC21 GO:0003735,GO:0006412,GO:0005840 Rv1642 Rv1642 AL450380.2 Mycobrowser_v4 CDS 1668341 1671250 . + 0 ML1392 uvrA INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). UVRA IS AN ATPASE AND A DNA-BINDING PROTEIN THAT PREFERENTIALLY BINDS SINGLE-STRANDED OR UV-IRRADIATED DOUBLE-STRANDED DNA. PROBABLE EXCINUCLEASE ABC (SUBUNIT A - DNA-BINDING ATPase) UVRA ML1392, len: 969 aa. Probable excinuclease ABC subunit A> Highly similar to many excinucleases ABC (subunit A), involved in DNA repair following UV damage, including: Micrococcus luteus SW:UVRA_MICLU (P13567) (992 aa), Fasta scores: E(): 0, 69.3% identity in 966 aa overlap and Mycobacterium tuberculosis Rv1638 SW:UVRA_MYCTU (P94972) (972 aa), Fasta scores: E(): 0, 90.9% identity in 975 aa overlap. Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Q9CC24 No information pathways PF00005 Q9CC24 GO:0016887,GO:0003677,GO:0009432,GO:0005737,GO:0009381,GO:0009380,GO:0006289,GO:0008270,GO:0005524 Rv1638 Rv1638 AL450380.2 Mycobrowser_v4 CDS 2074931 2075668 . - 0 ML1719c ML1719c POSSIBLE TRANSFERASE ML1719c, len: 245 aa. Possible transferase. Highly similar to Mycobacterium tuberculosis Rv3034c TR:O53281 (EMBL:AL021287) (300 aa), Fasta scores: E(): 0, 90.6% identity in 244 aa overlap. The C-terminus of this protein is weakly similar to several including: Escherichia coli putative lipopolysaccharide biosynthesis O-acetyl transferase SW:WBBJ_ECOLI (P37750) (196 aa), Fasta scores: E(): 4.3e-09, 35.8% identity in 134 aa overlap. Q9CBR1 No intermediary metabolism and respiration Q9CBR1 GO:0016740 Rv3034c Rv3034c AL450380.2 Mycobrowser_v4 CDS 1687676 1688719 . + 0 ML1406 argC PROBABLE N-ACETL-GAMMA-GLUTAMYL-PHOSHATE REDUCTASE ARGC ML1406, len: 347 aa. Probable argC, N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38). Highly similar to many N-acetyl-gamma-glutamyl-phosphate reductases involved in arginine biosynthesis, including: Streptomyces coelicolor SW:ARGC_STRCO (AL031541) (342 aa), Fasta scores: E(): 0, 62.1% identity in 346 aa overlap and Mycobacterium tuberculosis Rv1652 SW:ARGC_MYCTU (P94987) (352 aa), Fasta scores: E(): 0, 81.1% identity in 344 aa overlap. Contains Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase. Contains PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. Q9CC15 No intermediary metabolism and respiration PF01118,PF02774 Q9CC15 GO:0051287,GO:0006526,GO:0005737,GO:0055114,GO:0046983,GO:0003942 1.2.1.38 Rv1652 Rv1652 AL450380.2 Mycobrowser_v4 CDS 1817338 1818384 . + 0 ML1506 ML1506 CONSERVED HYPOTHETICAL ALA-, PRO-RICH PROTEIN ML1506, len: 348 aa. Conserved hypothetical ala and proline rich protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1157c TR:O06555 (EMBL:Z95584) (371 aa), Fasta scores: E(): 0, 68.0% identity in 369 aa overlap. Note the predicted product of this CDS is rich in the amino acids Pro. Q9CBW8 No conserved hypotheticals Q9CBW8 Rv1157c Rv1157c AL450380.2 Mycobrowser_v4 CDS 1688716 1689939 . + 0 ML1407 argJ Probable Glutamate n-acetyltransferase ArgJ ML1407, len: 407 aa. Probable argJ, Glutamate n-acetyltransferase (EC 2.3.1.35). Highly similar to many glutamate N-acetyltransferases including: Corynebacterium glutamicum SW:ARGJ_CORGL (Q59280) (388 aa), Fasta scores: E(): 0, 58.2% identity in 392 aa overlap and Mycobacterium tuberculosis Rv1653 TR:P94988 (EMBL:Z85982) (404 aa), Fasta scores: E(): 0, 82.4% identity in 404 aa overlap. Contains Pfam match to entry PF01960 ArgJ, ArgJ family. Q9CC14 No intermediary metabolism and respiration PF01960 Q9CC14 GO:0006526,GO:0005737,GO:0004358,GO:0004042 2.3.1.1,2.3.1.35 Rv1653 Rv1653 AL450380.2 Mycobrowser_v4 CDS 1681041 1682093 . + 0 ML1401 pheS Probable phenylalanyl-tRNA synthetase, alpha chain PheS ML1401, len: 350 aa. Probable pheS, phenylalanyl-tRNA synthetase, alpha chain (EC 6.1.1.20). Highly similar to many phenylalanyl-tRNA synthetase alpha chains including: Escherichia coli SW:SYFA_ECOLI (P08312) (327 aa), Fasta scores: E(): 0, 45.9% identity in 331 aa overlap and Mycobacterium tuberculosis Rv1649 TR:P94984 (EMBL:Z85982) (341 aa), Fasta scores: E(): 0, 85.0% identity in 341 aa overlap. Contains Pfam match to entry PF01409 tRNA-synt_2d, tRNA synthetases class II (F). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Q9CC17 No information pathways PF01409,PF02912 Q9CC17 GO:0005737,GO:0000287,GO:0004826,GO:0006432,GO:0005524 6.1.1.20 Rv1649 Rv1649 AL450380.2 Mycobrowser_v4 CDS 1787390 1787878 . - 0 ML1484c ML1484c PROBABLE ISOMERASE ML1484c, len: 162 aa. Probable isomerase (EC 5.-.-.-). Similar to many isomerases including: Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) SW:RPIB_ECOLI (P37351) (149 aa), Fasta scores: E(): 2.8e-12, 32.9% identity in 146 aa overlap and Mycobacterium tuberculosis isomerase Rv2465c TR:O53192 (EMBL:AL021246) (162 aa), Fasta scores: E(): 0, 89.5% identity in 162 aa overlap. Q9CBY1 No intermediary metabolism and respiration PF02502 Q9CBY1 GO:0004751,GO:0005975 5.3.1.6 Rv2465c Rv2465c AL450380.2 Mycobrowser_v4 CDS 1700700 1701248 . - 0 ML1418c ML1418c conserved hypothetical protein ML1418c, len: 182 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis Rv1732c TR:P71990 (EMBL:Z81360) (182 aa), Fasta scores: E(): 0, 86.3% identity in 182 aa overlap and Synechocystis sp. TR:P73178 (EMBL:D90904) (194 aa), Fasta scores: E(): 0, 52.5% identity in 179 aa overlap. Q9CC07 No conserved hypotheticals PF00578 Q9CC07 GO:0045454,GO:0016491,GO:0016209 Rv1732c Rv1732c AL450380.2 Mycobrowser_v4 CDS 1050580 1050769 . + 0 ML0884A ML0884A hypothetical protein(pseudogene) ML0884A, len:189. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-09 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1704358 1706049 . - 0 ML1419c ML1419c Possible regulatory protein ML1419c, len: 563 aa. Possible regulatory protein. The N-terminus is similar to several sensory box proteins e.g. Q884C4 Sensory box/GGDEF domain/EAL domain protein from Pseudomonas syringae (730 aa), fasta scores: E(): 3.8e-22, (34.557% identity in 327 aa overlap). The C-terminus is similar to many hyptothetical proteins. Contains 3 Pfam matches to entry PF00989 PAS, PAS domain. Contains Pfam match to entry PF00990 GGDEF domain. Q7AQ57 No regulatory proteins PF00989,PF00990,PF08448 Q7AQ57 GO:0004871,GO:0007165,GO:0006355 AL450380.2 Mycobrowser_v4 CDS 1710511 1711500 . - 0 ML1423c ML1423c conserved hypothetical protein ML1423c, len: 329 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function including: Bacillus subtilis SW:YQHO_BACSU (P54513) (291 aa), Fasta scores: E(): 2.8e-24, 37.3% identity in 308 aa overlap and Mycobacterium tuberculosis Rv2037c TR:O53481 (EMBL:AL021899) (324 aa), Fasta scores: E(): 0, 80.5% identity in 323 aa overlap. Q7AQ55 No conserved hypotheticals, cell wall and cell processes PF01734 Q7AQ55 GO:0006629 Rv2037c Rv2037c AL450380.2 Mycobrowser_v4 CDS 1819561 1820052 . - 0 ML1508c ML1508c conserved hypothetical protein ML1508c, len: 163 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function including M. tuberculosis Rv1155 TR:O06553 (EMBL:Z95584) (147 aa), Fasta scores: E(): 0, 87.8% identity in 147 aa overlap and Streptomyces coelicolor TR:Q9XAG1 (EMBL:AL079356) (144 aa), Fasta scores: E(): 5.6e-25, 54.3% identity in 140 aa overlap. Q9CBW7 No conserved hypotheticals, intermediary metabolism and respiration PF01243 Q9CBW7 GO:0010181 Rv1155 Rv1155 AL450380.2 Mycobrowser_v4 CDS 1821253 1821960 . + 0 ML1511 npdA Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) ML1511, len: 237 aa. Probable npdA, NAD-dependent deacetylase (EC 3.5.1.-). Highly similar to several e.g. Mycobacterium tuberculosis Rv1151c TR:O06549 (EMBL:Z95584) (237 aa), Fasta scores: E(): 0, 85.2% identity in 237 aa overlap and Q8NSM4|NPD_CORGL NAD-dependent deacetylase from Corynebacterium glutamicum (Brevibacterium flavum) (258 aa), fasta scores: E(): 2e-48, (46.610% identity in 236 aa overlap). Contains Pfam match to entry PF02146 SIR2, Sir2 family. Belongs to the sirtuin family. Q9CBW6 No regulatory proteins PF02146 Q9CBW6 GO:0006342,GO:0005737,GO:0016811,GO:0006476,GO:0008270,GO:0070403 3.5.1.- Rv1151c Rv1151c AL450380.2 Mycobrowser_v4 CDS 1781330 1782211 . + 0 ML1478 mmuM CATALYZES METHYL TRANSFER FROM S-METHYLMETHIONINE OR S-ADENOSYLMETHIONINE (LESS EFFICIENT) TO HOMOCYSTEINE, SELENOHOMOCYSTEINE AND LESS EFFICIENTLY SELENOCYSTEINE [CATALYTIC ACTIVITY: S-ADENOSYL-L-METHIONINE + L-HOMOCYSTEINE = S-ADENOSYL-L-HOMOCYSTEINE + L-METHIONINE]. PROBABLE HOMOCYSTEINE S-METHYLTRANSFERASE MMUM (S-METHYLMETHIONINE:HOMOCYSTEINE METHYLTRANSFERASE) (CYSTEINE METHYLTRANSFERASE) ML1478, len: 293 aa. Probable mmuM, homocysteine S-methyltransferase (EC 2.1.1.10). Highly similar to many e.g. Escherichia coli homocysteine S-methyltransferase involved in methionine biosynthesis SW:MMUM_ECOLI (Q47690) (310 aa), Fasta scores: E(): 0, 49.8% identity in 293 aa overlap and Mycobacterium tuberculosis putative transferase Rv2458 TR:O53185 (302 aa), fasta score: E(): 7e-92, (78.840% identity in 293 aa overlap). Q9CBY5 No intermediary metabolism and respiration PF02574 Q9CBY5 GO:0008898 Rv2458 Rv2458 AL450380.2 Mycobrowser_v4 CDS 1782208 1782852 . - 0 ML1479c clpP2 PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) ML1479c, len: 214 aa. Probable clpP2, ATP-dependent Clp protease proteolytic subunit 2. Highly similar to many ATP-dependent Clp protease proteolytic subunits (EC 3.4.21.92) including: Yersinia enterocolitica SW:CLPP_YEREN (Q60107) (207 aa), Fasta scores: E(): 0, 47.1% identity in 204 aa overlap and Mycobacterium tuberculosis Rv2460c SW:CLP2_MYCTU (O53187) (214 aa), Fasta scores: E(): 0, 98.1% identity in 210 aa overlap. Highly similar to the adjoining CDS ML1480 in M. leprae. Contains Pfam match to entry PF00574 CLP_protease, Clp protease. Contains PS00381 Endopeptidase Clp serine active site. Q9CBY4 No intermediary metabolism and respiration PF00574 Q9CBY4 GO:0005737,GO:0006508,GO:0004252,GO:0005524 3.4.21.92 Rv2460c Rv2460c AL450380.2 Mycobrowser_v4 CDS 1102044 1102358 . - 0 ML0932A ML0932A hypothetical protein(pseudogene) ML0932A, len:314. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-07 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1782849 1783523 . - 0 ML1480c clpP1 PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) ML1480c, len: 224 aa. Probable clpP1, ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92). Highly similar to many ATP-dependent Clp protease proteolytic subunits including: Bacillus subtilis SW:CLPP_BACSU (P80244) (197 aa), Fasta scores: E(): 0, 54.5% identity in 187 aa overlap and Mycobacterium tuberculosis Rv2461c SW:CLP1_MYCTU (O53188) (200 aa), Fasta scores: E(): 0, 94.5% identity in 200 aa overlap. Highly similar to the adjoining CDS ML1479. Contains Pfam match to entry PF00574 CLP_protease, Clp protease. Note that previously known as clpP. Q9CBY3 No intermediary metabolism and respiration PF00574 Q9CBY3 GO:0005737,GO:0006508,GO:0004252,GO:0005524 3.4.21.92 Rv2461c Rv2461c AL450380.2 Mycobrowser_v4 CDS 1815366 1816658 . - 0 ML1504c ML1504c CONSERVED TRANSMEMBRANE PROTEIN ML1504c, len: 430 aa. Conserved transmembrane protein. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis possible membrane protein Rv1159 TR:O06557 (EMBL:Z95584) (431 aa), Fasta scores: E(): 0, 75.7% identity in 420 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q9CBX0 No cell wall and cell processes PF09594 Q9CBX0 Rv1159 Rv1159 AL450380.2 Mycobrowser_v4 CDS 1805545 1807431 . - 0 ML1498c typA POSSIBLE GTP-BINDING TRANSLATION ELONGATION FACTOR TYPA (TYROSINE PHOSPHORYLATED PROTEIN A) (GTP-BINDING PROTEIN) ML1498c, len: 628 aa. Possible typA, GTP-binding, protein elongation factor. Highly similar to several GTP-binding proteins including: Escherichia coli SW:TYPA_ECOLI (P32132) (591 aa), Fasta scores: E(): 0, 46.1% identity in 610 aa overlap which belongs to the GTP-binding elongation factor family and Mycobacterium tuberculosis hypothetical protein Rv1165 TR:O06563 (EMBL:Z95584) (628 aa), Fasta scores: E(): 0, 85.2% identity in 628 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains PS00301 GTP-binding elongation factors signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBX2 No information pathways PF00009,PF00679,PF03144 Q9CBX2 GO:0003924,GO:0005622,GO:0003746,GO:0005525 Rv1165 Rv1165 AL450380.2 Mycobrowser_v4 CDS 1816762 1817310 . + 0 ML1505 ML1505 CONSERVED HYPOTHETICAL ALA-, PRO-RICH PROTEIN ML1505, len: 182 aa. Conserved hypothetical Proline rich protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1158c TR:O06556 (EMBL:Z95584) (227 aa), Fasta scores: E(): 1.1e-16, 51.7% identity in 236 aa overlap. Note the predicted product of this CDS is rich in the amino acids Pro and Ala and displays multiple ProAla repeats. Q9CBW9 No conserved hypotheticals Q9CBW9 Rv1158c Rv1158c AL450380.2 Mycobrowser_v4 CDS 2539990 2540745 . + 0 ML2137 ML2137 conserved hypothetical protein ML2137, len: 251 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 27.4 kda protein Rv0883c SW:Y883_MYCTU (Q10545) fasta scores: E(): 0, 79.4% in 253 aa, and to Streptomyces coelicolor hypothetical 39.0 kda protein TR:O50529 (EMBL:AL009204) fasta scores: E(): 2.2e-19, 36.0% in 247 aa. Q7APY6 No conserved hypotheticals Q7APY6 Rv0883c Rv0883c AL450380.2 Mycobrowser_v4 CDS 1825649 1826413 . - 0 ML1514c thyX PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) ML1514c, len: 254 aa. Probable thyX, Thymidylate synthase (EC 2.1.1.148). Highly similar to several e.g Mycobacterium tuberculosis thyX, Thymidylate synthase Rv2754c or MTV002.19C TR:O33296 (EMBL:AL008967) (250 aa) fasta scores: E(): 0, 81.5% identity in 254 aa and to Brevibacterium lactofermentum thyX, Thymidylate synthase SW:YDAP_BRELA (P40111) (250 aa) fasta scores: E(): 0, 59.4% identity in 249 aa. Also similar to mycobacteriophage proteins; Mycobacteriophage D29 protein 48 SW:VG48_BPMD2 (O64238) (235 aa) fasta scores: E(): 4.9e-30, 43.8% id in 249 aa Q9CBW3 No intermediary metabolism and respiration PF02511 Q9CBW3 GO:0006231,GO:0050797,GO:0050660 2.1.1.148 Rv2754c Rv2754c AL450380.2 Mycobrowser_v4 CDS 1832480 1832977 . - 0 ML1518c dfrA DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) ML1518c, len: 165 aa. Probable dfrA, dihydrofolate reductase (EC 1.5.1.3). Highly similar to many dihydrofolate reductases including: Escherichia coli SW:DYR_ECOLI (P00379) (159 aa), Fasta scores: E(): 2e-15, 38.4% identity in 146 aa overlap and several reductases from Mycobacteria including M. tuberculosis Rv2763c TR:O30463 (EMBL:AF006616) (181 aa), Fasta scores: E(): 0, 68.9% identity in 161 aa overlap and M. avium TR:O30463. Contains Pfam match to entry PF00186 DiHfolate_red, Dihydrofolate reductase. Contains PS00075 Dihydrofolate reductase signature. Note previously known as folA. Q9CBW1 No intermediary metabolism and respiration PF00186 Q9CBW1 GO:0004146,GO:0006545,GO:0009165,GO:0006730,GO:0055114,GO:0050661 1.5.1.3 Rv2763c Rv2763c AL450380.2 Mycobrowser_v4 CDS 1689936 1690841 . + 0 ML1408 argB Probable Acetylglutamate kinase ArgB (NAG kinase) (N-acetyl-L-glutamate 5-phosphotransferase ) ML1408, len: 301 aa. Probable argB, Acetylglutamate kinase (EC 2.7.2.8). Highly similar to many acetylglutamate kinases involved in arginine biosynthesis, including: Corynebacterium glutamicum SW:ARGB_CORGL (Q59281) (294 aa), Fasta scores: E(): 0, 64.1% identity in 270 aa overlap and Mycobacterium tuberculosis Rv1654 SW:ARGB_MYCTU (P94989) (294 aa), Fasta scores: E(): 0, 87.5% identity in 288 aa overlap. Contains Pfam match to entry PF01960 ArgJ, ArgJ family. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Belongs to the acetylglutamate kinase family. Q9CC13 No intermediary metabolism and respiration PF00696 Q9CC13 GO:0003991,GO:0006526,GO:0005737,GO:0005524 2.7.2.8 Rv1654 Rv1654 AL450380.2 Mycobrowser_v4 CDS 1699652 1700458 . + 0 ML1417 cdh possible CDP-diacylglycerol pyrophosphatase Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase) ML1417, len: 268 aa. Possible CDP-diacylglycerol pyrophosphatase. Similar to several CDP-diacylglycerol pyrophosphatases (EC 3.6.1.26) involved in phospholipid biosynthesis, including: CDH_SALTY|P26219 from Salmonella typhimurium (251 aa), Fasta scores: E(): 1.6e-25, (39.1% identity in 220 aa overlap) and Rv2289|CDH_MYCTU|Q50676 from Mycobacterium tuberculosis (260 aa), Fasta scores: E(): 0, (66.4% identity in 256 aa overlap). Q9CC08 No lipid metabolism PF02611 Q9CC08 GO:0016021,GO:0008654,GO:0005886,GO:0008715 3.6.1.26 Rv2289 Rv2289 AL450380.2 Mycobrowser_v4 CDS 1824631 1825533 . - 0 ML1513c dapA PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) (DIHYDRODIPICOLINATE SYNTHETASE) ML1513c, len: 300 aa. Probable dapA, dihydrodipicolinate synthase (EC 4.2.1.52). Highly similar to many dihydrodipicolinate synthases including: Brevibacterium lactofermentum SW:DAPA_BRELA (P40109) (301 aa), Fasta scores: E(): 0, 58.0% identity in 288 aa overlap and Mycobacterium tuberculosis Rv2753c TR:O33295 (EMBL:AL008967) (300 aa), Fasta scores: E(): 0, 86.7% identity in 300 aa overlap. Contains Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase family. Contains PS00665 Dihydrodipicolinate synthetase signature 1. Contains PS00666 Dihydrodipicolinate synthetase signature 2. Q9CBW4 No intermediary metabolism and respiration PF00701 Q9CBW4 GO:0019877,GO:0008840,GO:0005737 4.2.1.52 Rv2753c Rv2753c AL450380.2 Mycobrowser_v4 CDS 1675811 1676368 . + 0 ML1394 infC PROBABLE INITIATION FACTOR IF-3 INFC ML1394, len: 185 aa. Probable infC, initiation factor IF-3. Highly similar to many translation initiation factors (3) including: Neisseria meningitidis TR:AAF41134 (EMBL:AE002426) (155 aa), Fasta scores: E(): 3.8e-28, 48.7% identity in 152 aa overlap, Bacillus subtilis SW:IF3_BACSU (P55872) (171 aa), Fasta scores: E(): 1.4e-26, 48.7% identity in 150 aa overlap and Mycobacterium tuberculosis Rv1641 SW:IF3_MYCTU (P94975) (201 aa), Fasta scores: E(): 0, 89.2% identity in 185 aa overlap. Contains Pfam match to entry PF00707 IF3, Translation initiation factor IF-3. Contains PS00938 Initiation factor 3 signature. Q9CC22 No information pathways PF00707,PF05198 Q9CC22 GO:0003743,GO:0006413,GO:0005737 Rv1641 Rv1641 AL450380.2 Mycobrowser_v4 CDS 2041275 2041766 . + 0 ML1693A ML1693A putative Trp repressor binding protein(pseudogene) ML1693A, len:491. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-44 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2468743 2469231 . - 0 ML2076c ML2076c CONSERVED HYPOTHETICAL PROTEIN CFP17 HOMOLOG ML2076c, len: 162 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 17.3 kda protein Rv1827 SW:YI27_MYCTU (Q50606) (162 aa), fasta scores: E(): 0, 87.0% in 161 aa, and to Streptomyces coelicolor hypothetical 28.1 kda protein TR:CAB88880 (EMBL:AL353861) fasta scores: E(): 1.9e-25, 54.6% in 141 aa. Contains Pfam match to entry PF00498 FHA, FHA domain. Q7APZ3 No conserved hypotheticals PF00498 Q7APZ3 Rv1827 Rv1827 AL450380.2 Mycobrowser_v4 CDS 1537588 1538118 . + 0 ML1289 ML1289 CONSERVED HYPOTHETICAL PROTEIN TB18.6 HOMOLOG ML1289, len: 176 aa. Conserved hypothetical protein. Similar to many proteins of undefined function including: Mycobacterium tuberculosis Rv2140c SW:YL40_MYCTU (O06235) (176 aa), Fasta scores: E(): 0, 86.3% identity in 175 aa overlap and Escherichia coli SW:YBCL_ECOLI (P77368) (183 aa), Fasta scores: E(): 1.1e-21, 45.3% identity in 161 aa overlap. Note this CDS contains a strong Pfam hit to the Eukaryotic phosphatidylethanolamine-binding protein motif. In Eukaryotes this motif is associated with the binding of hydrophobic ligands and nucleotides. Contains Pfam match to entry PF01161 PBP, Phosphatidylethanolamine-binding protein. Q9CC45 No conserved hypotheticals PF01161 Q9CC45 Rv2140c Rv2140c AL450380.2 Mycobrowser_v4 CDS 1872644 1873609 . - 0 ML1548c ML1548c conserved hypothetical protein ML1548c, len: 321 aa. Conserved hypothetical protein. Highly similar to several proteins of unknown function including: Streptomyces coelicolor TR:O88028 (EMBL:AL031107) (295 aa), Fasta scores: E(): 0, 54.4% identity in 285 aa overlap and Mycobacterium tuberculosis TR:O33337 (EMBL:AL00896) (324 aa), Fasta scores: E(): 0, 87.4% identity in 318 aa overlap. Q7AQ44 No conserved hypotheticals PF00149 Q7AQ44 GO:0016787 Rv2795c Rv2795c AL450380.2 Mycobrowser_v4 CDS 1619878 1621641 . + 0 ML1360 recN PROBABLE DNA REPAIR PROTEIN RECN (RECOMBINATION PROTEIN N) ML1360, len: 587 aa. Probable recN, DNA repair protein. Highly similar to many recombinational repair protein (RecN) orthologues including: Bacillus subtilis SW:RECN_BACSU (P17894) (576 aa), Fasta scores: E(): 7.4e-26, 30.3% identity in 597 aa overlap and Mycobacterium tuberculosis Rv1696 TR:O33197 (EMBL:Z98268) (587 aa), Fasta scores: E(): 0, 76.2% identity in 589 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q49896 No information pathways PF02463 Q49896 GO:0006310,GO:0006281,GO:0005694,GO:0005524 Rv1696 Rv1696 AL450380.2 Mycobrowser_v4 CDS 1713481 1714440 . - 0 ML1426c ML1426c Probable sugar-transport integral membrane protein ABC transporter ML1426c, len: 319 aa. Probable sugar-transport integral membrane protein ABC transporter. Highly similar to many putative ABC_transport proteins e.g. Mycobacterium tuberculosis sugar transport protein Rv2040c TR:O53484 (EMBL:AL021899) (300 aa), Fasta scores: E(): 0, 81.6% identity in 293 aa overlap. Also similar to ML1768 from M. leprae. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Q7AQ52 No cell wall and cell processes PF00528 Q7AQ52 GO:0016021,GO:0005886,GO:0005351,GO:0008643 Rv2040c Rv2040c AL450380.2 Mycobrowser_v4 CDS 1801892 1802818 . - 0 ML1495c mshB Involved in mycothiol biosynthesis. 1-D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins)is converted to 1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside (GlcN-Ins) by this enzyme. Seems to possess weak mycothiol conjugate amidase activity but shows substantial deacetylation activity with 1-D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins), a hypothetical mycothiol biosynthetic precursor. GlcNAc-Ins is an intermediate in MSH biosynthesis. N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) ML1495c, len: 308 aa. Probable mshB, N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase. Highly similar to Mycobacterium tuberculosis Rv1170 TR:O50426 mshB (EMBL:AL010186) (303 aa), Fasta scores: E(): 0, 76.9% identity in 307 aa overlap and several proteins of unknown function including: Streptomyces lincolnensis LmbE TR:Q54358 (EMBL:X79146) (270 aa), Fasta scores: E(): 7.4e-13, 32.4% identity in 275 aa overlap and . Also similar to ML2391 from M. leprae. Q9CBX4 No conserved hypotheticals, intermediary metabolism and respiration PF02585 Q9CBX4 Rv1170 Rv1170 AL450380.2 Mycobrowser_v4 CDS 1846971 1848086 . + 0 ML1532 ald SECRETED L-ALANINE DEHYDROGENASE ALD (40 KDA ANTIGEN) (TB43) ML1532, len: 371 aa. Probable ald, secreted L-alanine dehydrogenase (EC 1.4.1.1). Highly similar to many alanine dehydrogenases including: Bacillus sphaericus SW:DHA_BACSH (P175566) (372 aa), Fasta scores: E(): 0, 53.4% identity in 365 aa overlap and Mycobacterium tuberculosis Rv2780 SW:DHA_MYCTU (P30234) (371 aa), Fasta scores: E(): 0, 85.4% identity in 371 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Contains PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. Contains PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. Q9CBV6 No intermediary metabolism and respiration PF01262,PF05222 Q9CBV6 GO:0005488,GO:0009055,GO:0008152,GO:0000286 Rv2780 Rv2780 AL450380.2 Mycobrowser_v4 CDS 2231745 2231930 . - 0 ML1846c rpsN PROBABLE 30S RIBOSOMAL PROTEIN S14 RPSN ML1846c, len: 61 aa. Probable rpsN, 30S ribosomal protein S14. Similar to M. tuberculosis 30S ribosomal protein S14-1 Rv0717 SW:R14A_MYCTU (P95065) (61 aa), Fasta scores: E(): 1.8e-25, 91.8% identity in 61 aa overlap. Contains Pfam match to entry PF00253 Ribosomal_S14, Ribosomal protein S14p/S29e. Contains PS00527 Ribosomal protein S14 signature. O32996 No information pathways PF00253 O32996 GO:0005840,GO:0003735,GO:0006412,GO:0008270,GO:0019843 Rv0717 Rv0717 AL450380.2 Mycobrowser_v4 CDS 1583614 1584474 . + 0 ML1332 tatC INVOLVED IN PROTEINS EXPORT: REQUIRED FOR CORRECT LOCALIZATION OF PRECURSOR PROTEINS BEARING SIGNAL PEPTIDES WITH THE TWIN ARGININE CONSERVED MOTIF S/T-R-R-X-F-L-K. THIS SEC-INDEPENDENT PATHWAY IS TERMED TAT FOR TWIN-ARGININE TRANSLOCATION SYSTEM. THIS SYSTEM MAINLY TRANSPORTS PROTEINS WITH BOUND COFACTORS THAT REQUIRE FOLDING PRIOR TO EXPORT. Probable Sec-independent protein translocase transmembrane protein TatC ML1332, len: 286 aa. Probable tatC, Sec-independent protein translocase transmembrane protein. Similar to many membrane proteins including: Escherichia coli Sec-independent protein translocase protein TatC SW:TATC_ECOLI (AJ005830) (258 aa), Fasta scores: E(): 1.6e-17, 33.0% identity in 267 aa overlap and Mycobacterium tuberculosis Rv2093c SW:YK93_MYCTU (Q10702) (308 aa), Fasta scores: E(): 0, 86.0% identity in 286 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Contains Pfam match to entry PF00902 UPF0032, MttB family. Contains PS01218 Uncharacterized protein family UPF0032 signature. P54078 No cell wall and cell processes PF00902 P54078 GO:0065002,GO:0005886,GO:0016021 Rv2093c Rv2093c AL450380.2 Mycobrowser_v4 CDS 1879675 1880169 . - 0 ML1555c rbfA PROBABLE RIBOSOME-BINDING FACTOR A RBFA (P15B PROTEIN) ML1555c, len: 164 aa. Probable rbfA, ribosome-binding factor A. Highly similar to several ribosome-binding factors essential for efficient processing of 16s rRNA including: Escherichia coli SW:RBFA_ECOLI (P09170) (132 aa), Fasta scores: E(): 8.5e-05, 33.1% identity in 118 aa overlap and Mycobacterium tuberculosis Rv2838c SW:RBFA_MYCTU (P71614) (183 aa), Fasta scores: E(): 0, 75.6% identity in 160 aa overlap. Contains Pfam match to entry PF02033 RBFA, Ribosome-binding factor A. Contains PS01319 Ribosome-binding factor A signature. Q9Z5I8 No information pathways PF02033 Q9Z5I8 GO:0006364,GO:0005737 Rv2838c Rv2838c AL450380.2 Mycobrowser_v4 CDS 1883542 1884585 . - 0 ML1558c nusA PROBABLE N UTILIZATION SUBSTANCE PROTEIN A NUSA ML1558c, len: 347 aa. Probable nusA, N-utilization substance protein A. Highly similar to many transcriptional terminators/s including: Escherichia coli N utilization substance protein A SW:NUSA_ECOLI (X00513) (495 aa), Fasta scores: E(): 2e-30, 33.1% identity in 363 aa overlap and O05818|NUSA_MYCTU Transcription elongation protein from Mycobacterium tuberculosis (347 aa), fasta scores: E(): 4.5e-127, (91.931% identity in 347 aa overlap). Contains Pfam match to entry PF00013 KH-domain, KH domain. Q9Z5J1 No information pathways PF08529 Q9Z5J1 GO:0005515,GO:0031564,GO:0003700,GO:0006353,GO:0003723 AL450380.2 Mycobrowser_v4 CDS 1898989 1899738 . - 0 ML1573c ML1573c possible amidotransferase ML1573c, len: 249 aa. Possible amidotransferase (EC 6.3.5.-). Similar to several e.g. Mycobacterium tuberculosis Rv2859c TR:O33341. Also similar in regions to Dictyostelium discoideum GMP synthase (EC 6.3.5.2) (glutamine amidotransferase) SW:GUAA_DICDI (P32073) (718 aa), Fasta scores: E(): 0.0045, 26.7% identity in 176 aa overlap. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Q9CBU9 No intermediary metabolism and respiration PF07722 Q9CBU9 GO:0016787,GO:0016740,GO:0006541 Rv2859c Rv2859c AL450380.2 Mycobrowser_v4 CDS 1908221 1909441 . - 0 ML1583c dxr PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE) ML1583c, len: 406 aa. Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.-). Highly similar to many 1-deoxy-D-xylulose 5-phosphate reductoisomerases involved in terpenoid biosynthesis e.g. Escherichia coli SW:DXR_ECOLI (P45568) (195 aa), BlastP Expect 9.4 and Mycobacterium tuberculosis Rv2870c SW:DXR_MYCTU (Q10798) (413 aa), Fasta scores: E(): 0, 84.3% identity in 395 aa overlap. Q9CBU3 No intermediary metabolism and respiration PF02670,PF08436 Q9CBU3 GO:0046872,GO:0055114,GO:0016114,GO:0030604 1.1.1.267 Rv2870c Rv2870c AL450380.2 Mycobrowser_v4 CDS 1103543 1103837 . + 0 ML0933A ML0933A hypothetical protein(pseudogene) ML0933A, len:294. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-11 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1900892 1901749 . - 0 ML1576c mapB PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) ML1576c, len: 285 aa. Probable mapB, methionine aminopeptidase (EC 3.4.11.18). Highly similar to many methionine aminopeptidases responsible for removing the amino-terminal methionine from many nascent proteins e.g. Escherichia coli SW:AMPM_ECOLI (P07906) (264 aa), Fasta scores: E(): 0, 51.4% identity in 247 aa overlap and Mycobacterium tuberculosis Rv2861c SW:AMPM_MYCTU (O33343) (285 aa), Fasta scores: E(): 0, 89.8% identity in 283 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24. Contains PS00680 Methionine aminopeptidase subfamily 1 signature. Q9CBU7 No intermediary metabolism and respiration PF00557 Q9CBU7 GO:0008235,GO:0006508,GO:0004177 3.4.11.18 Rv2861c Rv2861c AL450380.2 Mycobrowser_v4 CDS 2346900 2347274 . - 0 ML1960c rpsM PROBABLE 30S RIBOSOMAL PROTEIN S13 RPSM ML1960c, len: 124 aa. Probable rpsM, 30S ribosomal protein S13. Similar to M. tuberculosis 30S ribosomal protein S13 rpsM Rv3460c SW:RS13_MYCTU (O06327) (124 aa), Fasta scores: E(): 0, 92.7% identity in 124 aa overlap. Contains Pfam match to entry PF00416 Ribosomal_S13, Ribosomal protein S13/S18. Contains PS00646 Ribosomal protein S13 signature. Q9X7A1 No information pathways PF00416 Q9X7A1 GO:0005840,GO:0003735,GO:0000049,GO:0006412,GO:0019843 Rv3460c Rv3460c AL450380.2 Mycobrowser_v4 CDS 1854791 1856494 . - 0 ML1538c mycP5 PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) ML1538c, len: 567 aa. Probable mycP5, proline rich membrane-anchored mycosin. Highly similar to several from Mycobacterium tuberculosis including: O53945|Rv1796 mycP5, proline rich membrane-anchored mycosin (585 aa), fasta scores: E(): 2e-134, (73.077% identity in 572 aa overlap); and Rv0291 TR:O53695 (EMBL:AL021930) mycP3, membrane-anchored serine protease (461 aa), Fasta scores: E(): 0, 37.6% identity in 572 aa overlap. Also similar to ML2528 and ML0041 from M. leprae. Contains possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00082 Peptidase_S8, Subtilase family. Contains PS00136 Serine proteases. Contains PS00137 Serine proteases. Q9CBV3 No intermediary metabolism and respiration PF00082 Q9CBV3 GO:0004252,GO:0006508 Rv1796 Rv1796 AL450380.2 Mycobrowser_v4 CDS 3038236 3039153 . + 0 ML2550 ML2550 conserved hypothetical protein ML2550, len: 305 aa. Conserved hypothetical protein. Similar to many proteins of undefined function including: Mycobacterium tuberculosis hypothetical 32.2 kDa protein Rv0263c TR:P95220 (EMBL:Z86089) fasta scores: E(): 0, 78.3% identity in 286 aa, and to Escherichia coli hypothetical 34.4 kDa protein in SW:YBGK_ECOLI (P75745) fasta scores: E(): 2.6e-26, 35.5% identity in 304 aa. Q9CD25 No conserved hypotheticals PF02626 Q9CD25 Rv0263c Rv0263c AL450380.2 Mycobrowser_v4 CDS 2048067 2049185 . + 0 ML1699 lppZ PROBABLE CONSERVED LIPOPROTEIN LPPZ ML1699, len: 372 aa. Probable lppZ, conserved lipoprotein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv3006 TR:O53253 (EMBL:AL021287) (373 aa), Fasta scores: E(): 0, 87.1% identity in 373 aa overlap. Contains possible membrane spanning hydrophobic domains. ontains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7AQ26 No cell wall and cell processes Q7AQ26 GO:0003824 Rv3006 Rv3006 AL450380.2 Mycobrowser_v4 CDS 2834624 2834965 . - 0 ML2366c ML2366c POSSIBLE CONSERVED MEMBRANE PROTEIN ML2366c, len: 113 aa. Possible conserved membrane protein. Similar to Mycobacterium tuberculosis membrane protein Rv3760 or MTV025.108 TR:O69726 (EMBL:AL022121) (100 aa) fasta scores: E(): 1.9e-19, 67.7% identity in 99 aa. Contains possible membrane spanning hydrophobic domains. Q7APV5 No cell wall and cell processes Q7APV5 Rv3760 Rv3760 AL450380.2 Mycobrowser_v4 CDS 2230328 2230693 . - 0 ML1843c rplR PROBABLE 50S RIBOSOMAL PROTEIN L18 RPLR ML1843c, len: 121 aa. Probable rplR, 50S ribosomal protein L18. Similar to M. tuberculosis 50S ribosomal protein L18 Rv0720 SW:RL18_MYCTU (P95068) (122 aa), Fasta scores: E(): 0, 87.5% identity in 120 aa overlap. Contains Pfam match to entry PF00861 Ribosomal_L18p, Ribosomal L18p/L5e family. O32999 No information pathways PF00861 O32999 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0720 Rv0720 AL450380.2 Mycobrowser_v4 CDS 2722017 2722991 . + 0 ML2297 ephE POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) ML2297, len: 324 aa. Possible ephE, epoxide hydrolase (EC 3.3.2.3). Similar to Mycobacterium tuberculosis putative epoxide hydrolase Rv3670|ephE or MTV025.018 TR:O69638 (EMBL:AL022121) (327 aa) fasta scores: E(): 0, 80.6% identity in 324 aa. Similarto many putative hydrolases and shows weak similarity to Homo sapiens soluble epoxide hydrolase ephX2 SW:HYES_HUMAN (P34913) (554 aa) fasta scores: E(): 3.1e-12, 28.1% id in 285 aa. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Q9CB96 No virulence, detoxification, adaptation PF00561 Q9CB96 GO:0016787 Rv3670 Rv3670 AL450380.2 Mycobrowser_v4 CDS 2846373 2846837 . + 0 ML2377 mmpS4 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4 ML2377, len: 154 aa. Probable mmpS4, conserved membrane protein. Similar to Mycobacterium tuberculosis putative membrane protein Rv0451c SW:MMS4_MYCTU (O53736) (140 aa) fasta scores: E(): 0, 75.0% identity in 140 aa, and to Mycobacterium avium TmtpA TR:Q9XCF4 (EMBL:AF143772) (221 aa) fasta scores: E(): 0, 58.9% identity in 146 aa. Contains a possible N-terminal signal sequence and other possible membrane spanning hydrophobic domains. P54880 No cell wall and cell processes PF05423 P54880 GO:0005886,GO:0016021 Rv0451c Rv0451c AL450380.2 Mycobrowser_v4 CDS 2604280 2605056 . - 0 ML2189c phoT PROBABLE PHOSPHATE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PHOT ML2189c, len: 258 aa. Probable phoT, phosphate-transport ATP-binding protein ABC transporter. Similar to Mycobacterium tuberculosis phosphate transport system ATP-binding protein TR:O53832 (EMBL:AL022004) fasta scores: E(): 0, 91.5% in 258 aa, and to Escherichia coli phosphate transport ATP-binding protein pstb SW:PSTB_ECOLI (P07655) fasta scores: E(): 0, 52.9% in 255 aa. Also similar to ML1892, ML1114, ML1113, ML1122, ML1089, ML1424, ML0336, ML2352, ML1726, ML0669, ML0590 and ML1816 from M. leprae. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Q50046 No cell wall and cell processes PF00005 Q50046 GO:0005315,GO:0015415,GO:0006817,GO:0005886,GO:0005524 3.6.3.27 Rv0820 Rv0820 AL450380.2 Mycobrowser_v4 CDS 2870659 2871516 . - 0 ML2400c ML2400c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2400c, len: 285 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis putative transmembrane protein Rv1072 or MTV017.25 TR:O53420 (EMBL:AL021897) (278 aa) fasta scores: E(): 0, 77.5% identity in 285 aa, and to Streptomyces griseus transfer RNA-leu TR:Q54192 (EMBL:M80628) (293 aa) fasta scores: E(): 4.3e-27, 40.0% identity in 300 aa. Contains multiple possible membrane spanning hydrophobic domains. Q9CB64 No cell wall and cell processes PF06539 Q9CB64 GO:0016021 Rv1072 Rv1072 AL450380.2 Mycobrowser_v4 CDS 2554752 2555276 . + 0 ML2151 ML2151 conserved hypothetical protein ML2151, len: 174 aa. Conserved hypothetical protein. Similar to C-terminus of Mycobacterium tuberculosis rpfA, resuscitation-promoting factor TR:O53879 (EMBL:AL022004) fasta scores: E(): 4.8e-29, 63.0% in 200 aa. Also similar to ML0240 and ML2030 from M. leprae. Q7APY1 No conserved hypotheticals, cell wall and cell processes PF06737 Q7APY1 GO:0005576 Rv0867c Rv0867c AL450380.2 Mycobrowser_v4 CDS 2418627 2419610 . + 0 ML2028 fbpB INVOLVED IN CELL WALL MYCOLOYLATION. PROTEINS OF THE ANTIGEN 85 COMPLEX ARE RESPONSIBLE FOR THE HIGH AFFINITY OF MYCOBACTERIA TO FIBRONECTIN. POSSESSES A MYCOLYLTRANSFERASE ACTIVITY REQUIRED FOR THE BIOGENESIS OF TREHALOSE DIMYCOLATE (CORD FACTOR), A DOMINANT STRUCTURE NECESSARY FOR MAINTAINING CELL WALL INTEGRITY. SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR ALPHA-ANTIGEN) ML2028, len: 327 aa. Probable fbpB, secreted antigen (85A), mycolyltransferase (EC 2.3.1.-). Similar to Mycobacterium kansasii antigen 85-B precursor SW:A85B_MYCKA (P21160) fasta scores: E(): 0, 85.8% in 324 aa, and to Mycobacterium avium antigen 85-B precursor SW:A85B_MYCAV (Q06947) fasta scores: E(): 0, 81.2% in 329 aa and P31952|A85B_MYCTU|Rv1886c Antigen 85-B precursor (85B) from M. tuberculosis (325 aa), fasta scores: E(): 1.6e-115, (83.025% identity in 324 aa overlap). Also similar to ML0097, ML2655 and ML0098 from M. leprae. Contains Pfam match to entry PF00756 Esterase, Putative esterase. P31951 No lipid metabolism PF00756 P31951 GO:0005576,GO:0008415 2.3.1.- Rv1886c Rv1886c AL450380.2 Mycobrowser_v4 CDS 2489138 2490052 . - 0 ML2093c pstA1 PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA1 ML2093c, len: 304 aa. Probable pstA1, phosphate-transport integral membrane ABC transporter. Similar to Mycobacterium tuberculosis phosphate transport system permease protein pstA1 TR:O86344 (EMBL:Z47983) fasta scores: E(): 0, 83.0% in 317 aa, and to Escherichia coli phosphate transport system permease protein pstc SW:PSTC_ECOLI (P07653) fasta scores: E(): 1.7e-30, 33.9% in 304 aa. Also similar to ML0930 a possible pseudogene similar to M. tuberculosis pstA1. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Q50097 No cell wall and cell processes PF00528 Q50097 GO:0005315,GO:0016021,GO:0006817,GO:0005886,GO:0009276 Rv0930 Rv0930 AL450380.2 Mycobrowser_v4 CDS 2241072 2241914 . - 0 ML1860c rplB PROBABLE 50S ribosomal protein L2 RPLB ML1860c, len: 280 aa. Probable rplB, 50S ribosomal protein L2. Similar to M. tuberculosis 50S ribosomal protein L2 Rv0704 SW:RL2_MYCTU (P95052) (280 aa), Fasta scores: E(): 0, 92.1% identity in 280 aa overlap. Contains Pfam match to entry PF00181 Ribosomal_L2, Ribosomal Proteins L2. Contains PS00467 Ribosomal protein L2 signature. O32984 No information pathways PF00181,PF03947 O32984 GO:0019843,GO:0003735,GO:0016740,GO:0006412,GO:0015934 Rv0704 Rv0704 AL450380.2 Mycobrowser_v4 CDS 2005644 2006117 . - 0 ML1664c ML1664c POSSIBLE METHYLTRANSFERASE (METHYLASE) ML1664c, len: 157 aa. Possible methyltransferase (EC 2.1.1.-). Similar to Mycobacterium tuberculosis Rv2966c TR:P95128 (EMBL:Z83018) (188 aa), Fasta scores: E(): 0, 72.9% identity in 155 aa overlap and Neisseria meningitidis possible DNA methylase TR:CAB83466 (EMBL:AL162752) (189 aa), Fasta scores: E(): 3.6e-07, 39.6% identity in 96 aa overlap. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Q9CBS5 No intermediary metabolism and respiration PF03602 Q9CBS5 Rv2966c Rv2966c AL450380.2 Mycobrowser_v4 CDS 2636012 2636686 . - 0 ML2219c purQ PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I PURG (FGAM SYNTHASE I) ML2219c, len: 224 aa. Probable purQ, phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3). Similar to Mycobacterium tuberculosis putative phosphoribosylformylglycinamidine synthase I Rv0788 OR MTCY369.32 TR:P71841 (EMBL:Z80226) fasta scores: E(): 0, 88.7% identity in 222 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine synthase I PURQ SW:PURQ_BACSU (P12041) fasta scores: E(): 0, 47.2% identity in 214 aa. Contains PS00442 Glutamine amidotransferases class-I active site. O05756 No intermediary metabolism and respiration PF07685 O05756 GO:0005524,GO:0009236,GO:0005737,GO:0006541,GO:0004642,GO:0006189,GO:0016879 6.3.5.3 Rv0788 Rv0788 AL450380.2 Mycobrowser_v4 CDS 2824110 2824895 . - 0 ML2359c tesA PROBABLE THIOESTERASE TESA ML2359c, len: 261 aa. Probable tesA, thioesterase (EC 3.1.2.-). Similar to several thioesterases associated with macrolide anitbiotic production e.g. Streptomyces griseus probable cadicidin biosynthesis thioesterase SW:PABT_STRGR (P33586) (361 aa) fasta scores: E(): 4.9e-24, 34.4% identity in 221 aa. Also similar to Mycobacterium tuberculosis probable thioesterase Rv2928 SW:YT28_MYCTU (Q10974) (261 aa) fasta scores: E(): 0, 74.7% identity in 249 aa. Contains Pfam match to entry PF00975 Thioesterase, Thioesterase domain. Q9Z5K4 No lipid metabolism PF00975 Q9Z5K4 GO:0016788,GO:0009058 3.1.2.- Rv2928 Rv2928 AL450380.2 Mycobrowser_v4 CDS 2603585 2604253 . + 0 ML2188 phoY2 PROBABLE PHOSPHATE-TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PHOY2 ML2188, len: 222 aa. Probable phoY2, phosphate-transport system regulatory protein. Similar to Mycobacterium tuberculosis phosphate transport system regulatory protein Rv0821c TR:O53833 (EMBL:AL022004) fasta scores: E(): 0, 93.0% in 213 aa, and to O07167|PHU1_MYCTU|Rv3301c Phosphate transport system regulatory protein (221 aa), fasta scores: E(): 9.9e-58, (61.468% identity in 218 aa overlap) and Rhizobium meliloti phosphate transport system regulatory protein SW:PHOU_RHIME (Q52989) fasta scores: E(): 1.5e-15, 30.1% in 216 aa. Also similar to ML0401c a possible pseudogene similar to M. tuberculosis phoY2. Q50047 No cell wall and cell processes PF01895 Q50047 GO:0006817,GO:0005737 Rv0821c Rv0821c AL450380.2 Mycobrowser_v4 CDS 2880048 2881031 . - 0 ML2409c ccsA POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCSA ML2409c, len: 327 aa. Possible ccsA, cytochrome C-type biogenesis protein, integral membrane protein. Similar to many cytochrome C biogenesis proteins including Mycobacterium tuberculosis Rv0529 TR:O06395 (EMBL:Z95558) (324 aa) fasta scores: E(): 0, 83.2% identity in 327 aa, and to Guillardia theta CcsA SW:CCSA_GUITH (P22554) (301 aa) fasta scores: E(): 5.5e-16, 35.6% identity in 261 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01578 CytC_asm, Cytochrome C assembly protein. Q7APV1 No intermediary metabolism and respiration PF01578 Q7APV1 GO:0008535,GO:0016020 Rv0529 Rv0529 AL450380.2 Mycobrowser_v4 CDS 2059823 2060899 . - 0 ML1707c trmU probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU ML1707c, len: 358 aa. Probable trmU, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61). Highly similar to many proposed tRNA (5-methylaminomethyl-2-thiouridylate) -methyltransferases including: Escherichia coli SW:TRMU_ECOLI (P25745) (368 aa), Fasta scores: E(): 0, 35.6% identity in 362 aa overlap and Mycobacterium tuberculosis Rv3024c SW:TRMU_MYCTU (O53271) (367 aa), Fasta scores: E(): 0, 85.2% identity in 357 aa overlap. O33099 No information pathways PF03054 O33099 GO:0005737,GO:0004808,GO:0000049,GO:0006400,GO:0005524 2.8.1.- Rv3024c Rv3024c AL450380.2 Mycobrowser_v4 CDS 1914874 1915431 . - 0 ML1590c frr RIBOSOME RECYCLING FACTOR FRR (RIBOSOME RELEASING FACTOR) (RRF) ML1590c, len: 185 aa. Probable frr, ribosome recycling factor. Highly similar to many ribosome releasing factors, involved in the release of ribosomes from messenger RNA at the termination of translation, e.g. Escherichia coli SW:RRF_ECOLI (P16174) (430 aa), BlastP Expect 9.8 and Mycobacterium tuberculosis Rv2882c SW:RRF_MYCTU (Q10794) (185 aa), Fasta scores: E(): 0, 90.8% identity in 185 aa overlap. Contains Pfam match to entry PF01765 RRF, Ribosome recycling factor. O33046 No information pathways PF01765 O33046 GO:0006415,GO:0005737 Rv2882c Rv2882c AL450380.2 Mycobrowser_v4 CDS 1915490 1916329 . - 0 ML1591c pyrH PROBABLE URIDYLATE KINASE PYRH (UK) (URIDINE MONOPHOSPHATE KINASE) (UMP KINASE) ML1591c, len: 279 aa. Probable pyrH, uridylate kinase uridylate kinase (EC 2.7.4.-). Highly similar to many uridylate kinases including: Escherichia coli SW:PYRH_ECOLI (P29464) (240 aa), Fasta scores: E(): 0, 46.1% identity in 232 aa overlap and Mycobacterium tuberculosis Rv2883c SW:PYRH_MYCTU (Q10791) (261 aa), Fasta scores: E(): 0, 85.0% identity in 274 aa overlap. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. O33045 No intermediary metabolism and respiration PF00696 O33045 GO:0005524,GO:0033862,GO:0008652,GO:0005737,GO:0006221,GO:0006207 2.7.4.22 Rv2883c Rv2883c AL450380.2 Mycobrowser_v4 CDS 1927810 1928130 . - 0 ML1602c ML1602c hypothetical protein ML1602c, len: 106 aa. Hypothetical unknown protein. Some similarity to Nikkomycin biosynthesis proteins e.g. Q93TU9 Nikkomycin biosynthesis protein SanS from Streptomyces ansochromogenes (424 aa), fasta scores: E(): 4.8e-13, (46.739% identity in 92 aa overlap). Q9CBT9 No unknown Q9CBT9 AL450380.2 Mycobrowser_v4 CDS 2051748 2051904 . - 0 ML1700A ML1700A hypothetical protein(pseudogene) ML1700A, len:156. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.033 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1924851 1925744 . - 0 ML1600c xerC PROBABLE INTEGRASE/RECOMBINASE XERC ML1600c, len: 297 aa. Probable xerC, integrase/recombinase. Highly similar to many integrase/recombinases including: Escherichia coli XerD, involved in site-specific recombination of plasmid ColE1 and chromosome partitioning, SW:XERD_ECOLI (P21891) (298 aa), Fasta scores: E(): 0, 41.5% identity in 301 aa overlap and Mycobacterium tuberculosis Rv2894c SW:YS94_MYCTU (Q10815) (298 aa), Fasta scores: E(): 0, 85.1% identity in 296 aa overlap. Also similar to ML1365 from M. leprae. Contains Pfam match to entry PF00589 Phage_integrase, 'Phage' integrase family. Q9CBU0 No insertion seqs and phages PF00589,PF02899 Q9CBU0 GO:0015074,GO:0007049,GO:0051301,GO:0007059,GO:0005737,GO:0006313,GO:0009037,GO:0003677 Rv2894c Rv2894c AL450380.2 Mycobrowser_v4 CDS 2059383 2059591 . - 0 ML1706A ML1706A PPE family protein(pseudogene) ML1706A, len:208. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2229646 2230299 . - 0 ML1842c rpsE PROBABLE 30S RIBOSOMAL PROTEIN S5 RPSE ML1842c, len: 217 aa. Probable rpsE, 30S ribosomal protein S5. Similar to M. tuberculosis 30S ribosomal protein S5 Rv0721 SW:RS5_MYCTU (P95069) (220 aa), Fasta scores: E(): 0, 87.9% identity in 190 aa overlap. Contains Pfam match to entry PF00333 Ribosomal_S5, Ribosomal protein S5. Contains PS00585 Ribosomal protein S5 signature. O33000 No information pathways PF00333,PF03719 O33000 GO:0015935,GO:0003735,GO:0006412,GO:0019843 Rv0721 Rv0721 AL450380.2 Mycobrowser_v4 CDS 1939459 1939998 . - 0 ML1616c rimM ESSENTIAL FOR EFFICIENT PROCESSING OF 16S RRNA. PROBABLY PART OF THE 30S SUBUNIT PRIOR TO OR DURING THE FINAL STEP IN THE PROCESSING OF 16S FREE 30S RIBOSOMAL SUBUNITS. IT COULD BE SOME ACCESSORY PROTEIN NEEDED FOR EFFICIENT ASSEMBLY OF THE 30S SUBUNIT. RIMM IS NEEDED IN A STEP PRIOR TO RBFA DURING THE MATURATION OF 16S RRNA. HAS AFFINITY FOR FREE RIBOSOMAL 30S SUBUNITS BUT NOT FOR 70S RIBOSOMES. PROBABLE 16S RRNA PROCESSING PROTEIN RIMM ML1616c, len: 179 aa. Probable rimB, 16S rRNA processing protein. Highly similar to many 16s rRNA processing proteins including: Escherichia coli SW:RIMM_ECOLI (P21504) (182 aa), Fasta scores: E(): 2.8e-10, 30.6% identity in 183 aa overlap and Mycobacterium tuberculosis Rv2907c SW:RIMM_MYCTU (Q10824) (176 aa), Fasta scores: E(): 0, 73.1% identity in 175 aa overlap. Contains Pfam match to entry PF01782 RimM, RimM. O33016 No information pathways PF01782,PF05239 O33016 GO:0042274,GO:0005840,GO:0043022,GO:0006364 Rv2907c Rv2907c AL450380.2 Mycobrowser_v4 CDS 1935445 1936167 . - 0 ML1611c rnhB PROBABLE RIBONUCLEASE HII PROTEIN RNHB (RNASE HII) ML1611c, len: 240 aa. Probable rnhB, ribonuclease HII protein (EC 3.1.26.4). Highly similar to many ribonucleases including: Brucella melitensis ribonuclease HII and Mycobacterium tuberculosis ribonuclease HII Rv2902c SW:RNH2_MYCTU (Q10793) (264 aa), Fasta scores: E(): 0, 76.7% identity in 245 aa overlap. Contains Pfam match to entry PF01351 RNase_HII, Ribonuclease HII. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O33022 No information pathways PF01351 O33022 GO:0006401,GO:0005737,GO:0030145,GO:0004523,GO:0003723 3.1.26.4 Rv2902c Rv2902c AL450380.2 Mycobrowser_v4 CDS 1937119 1937460 . - 0 ML1613c rplS PROBABLE 50S RIBOSOMAL PROTEIN L19 RPLS ML1613c, len: 113 aa. Probable rplS, 50S ribosomal protein L19. Highly similar to many 50s ribosomal proteins (L19) including: Bacillus stearothermophilus SW:RL19_BACST (P30529) (116 aa), Fasta scores: E(): 5e-31, 70.8% identity in 106 aa overlap and Mycobacterium tuberculosis Rv2904c SW:RL19_MYCTU (Q10792) (113 aa), Fasta scores: E(): 0, 93.8% identity in 113 aa overlap. Contains Pfam match to entry PF01245 Ribosomal_L19, Ribosomal protein L19. Contains PS01015 Ribosomal protein L19 signature. O33020 No information pathways PF01245 O33020 GO:0003735,GO:0006412,GO:0005840 Rv2904c Rv2904c AL450380.2 Mycobrowser_v4 CDS 1940270 1940752 . - 0 ML1618c rpsP PROBABLE 30S RIBOSOMAL PROTEIN S16 RPSP ML1618c, len: 160 aa. Probable rpsP, 30S ribosomal protein S16. Highly similar to many 30s ribosomal proteins (S16) including: Bacillus subtilis SW:RS16_BACSU (P21474) (89 aa), Fasta scores: E(): 2.1e-10, 45.1% identity in 82 aa overlap and Mycobacterium tuberculosis Rv2909c SW:RS16_MYCTU (Q10795) (162 aa), Fasta scores: E(): 0, 82.5% identity in 160 aa overlap. Contains Pfam match to entry PF00886 Ribosomal_S16, Ribosomal protein S16. Contains PS00732 Ribosomal protein S16 signature. O33014 No information pathways PF00886 O33014 GO:0003735,GO:0006412,GO:0005840 Rv2909c Rv2909c AL450380.2 Mycobrowser_v4 CDS 1962937 1964283 . - 0 ML1631c glnA2 PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) ML1631c, len: 448 aa. Probable glnA2, glutamine synthase class II (EC 6.3.1.2). Highly similar to many glutamine synthetases including: Bacillus subtilis SW:GLNA_BACSU (P12425) (443 aa), Fasta scores: E(): 0, 45.4% identity in 445 aa overlap and Mycobacterium tuberculosis Rv2222c SW:GLN2_MYCTU (Q10378) (446 aa), Fasta scores: E(): 0, 93.3% identity in 448 aa overlap. Also similar to ML0925 from M. leprae. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Q9CBT3 No intermediary metabolism and respiration PF00120,PF03951 Q9CBT3 GO:0006542,GO:0004356 Rv2222c Rv2222c AL450380.2 Mycobrowser_v4 CDS 1126817 1126894 . - 0 ML0958A ML0958A DNA-binding protein, putative(pseudogene) ML0958A, len:77. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.002 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2019284 2019967 . - 0 ML1675c ung PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG) ML1675c, len: 227 aa. Probable ung, uracil-DNA glycosylase (EC 3.2.2.-). Highly similar to many uracil-DNA glycosylases including: Streptococcus pneumoniae SW:UNG_STRPN (P23379) (123 aa), BlastP Expect 8.6 and Mycobacterium tuberculosis Rv2976c SW:UNG_MYCTU (P95119) (227 aa), Fasta scores: E(): 0, 88.5% identity in 227 aa overlap. Contains Pfam match to entry PF00315 UNG, Uracil-DNA glycosylase. Contains PS00130 Uracil-DNA glycosylase signature. Q9CBS3 No information pathways PF03167 Q9CBS3 GO:0005737,GO:0004844,GO:0006284 3.2.2.- Rv2976c Rv2976c AL450380.2 Mycobrowser_v4 CDS 2171519 2172727 . + 0 ML1794 ML1794 Probable aminotransferase ML1794, len: 402 aa. Probable aminotransferase (EC 2.6.1.-). Similar to M. tuberculosis predicted aminotransferase Rv2294 SW:YM94_MYCTU (Q50672) (407 aa), Fasta scores: E(): 0, 76.5% identity in 404 aa overlap, and to many others e.g. Escherichia coli MalY protein SW:MALY_ECOLI (P23256) (390 aa), Fasta scores: E(): 5.8e-27, 31.2% identity in 385 aa overlap. Also similar to ML2502 from M. leprae. Q9CBM9 No intermediary metabolism and respiration PF00155 Q9CBM9 GO:0009086,GO:0030170,GO:0016769,GO:0004121 4.4.1.8 Rv2294 Rv2294 AL450380.2 Mycobrowser_v4 CDS 1974017 1975132 . - 0 ML1637c ML1637c conserved hypothetical protein ML1637c, len: 371 aa. Conserved hypothetical protein. HIghly similar to Mycobacterium tuberculosis hypothetical protein Rv2228c SW:YM28_MYCTU (Q10512) (364 aa), Fasta scores: E(): 0, 76.8% identity in 371 aa overlap. The N-terminus is similar to several ribonucleases e.g. Escherichia coli ribonuclease HI (EC 3.1.26.4) SW:RNH_ECOLI (P00647) (430 aa), BlastP Expect 8.7. The C-terminus is similar to many proteins belonging to the phosphoglycerate mutase family e.g. Escherichia coli SW:COBC_ECOLI (P52086) (430 aa), BlastP Expect 8.7. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Q7AQ37 No conserved hypotheticals, information pathways PF00075,PF00300 Q7AQ37 GO:0004523,GO:0003676 Rv2228c Rv2228c AL450380.2 Mycobrowser_v4 CDS 1994536 1994883 . + 0 ML1654 acpM MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM ML1654, len: 115 aa. Probable acpM, meromycolate extension acyl carrier protein. Highly similar to many acyl carrier proteins involved in fatty acid biosynthesis including: Myxococcus xanthus SW:ACP_MYXXA (P80921) (78 aa), Fasta scores: E(): 6.1e-13, 59.5% identity in 74 aa overlap and Mycobacterium tuberculosis Rv2244 SW:ACP_MYCTU (Q10500) (115 aa), Fasta scores: E(): 0, 94.7% identity in 113 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. O69475 No lipid metabolism PF00550 O69475 GO:0048037,GO:0005737,GO:0006633,GO:0000036 Rv2244 Rv2244 AL450380.2 Mycobrowser_v4 CDS 1993522 1994436 . + 0 ML1653 fabD MALONYL CoA-ACYL CARRIER PROTEIN TRANSACYLASE FABD (Malonyl CoA:AcpM acyltransferase) (MCT) ML1653, len: 304 aa. Probable fabD, malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39). Similar to many malonyl CoA-acyl carrier protein transacylases involved in fatty acid biosynthesis, including: Salmonella typhimurium SW:FABD_SALTY (O85140) (308 aa), Fasta scores: E(): 1.6e-19, 32.7% identity in 303 aa overlap and Mycobacterium tuberculosis Rv2243 SW:FABD_MYCTU (Q10501) (302 aa), Fasta scores: E(): 0, 82.2% identity in 304 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. O69476 No lipid metabolism PF00698 O69476 GO:0008152,GO:0016740,GO:0005488 Rv2243 Rv2243 AL450380.2 Mycobrowser_v4 CDS 1992067 1993311 . + 0 ML1652 ML1652 conserved hypothetical protein ML1652, len: 414 aa. Conserved hypothetical protein. Highly similar to proteins of unknown function from Streptomyces coelicolor TR:Q9RDP8 (EMBL:AL133423) (401 aa), Fasta scores: E(): 4.3e-26, 42.0% identity in 383 aa overlap and Mycobacterium tuberculosis Rv2242 TR:YM42_MYCTU. Contains a probable helix-turn-helix motif at aa 359-380 (Score 1390, SD +3.92) Q7AQ34 No conserved hypotheticals Q7AQ34 Rv2242 Rv2242 AL450380.2 Mycobrowser_v4 CDS 2204733 2205086 . - 0 ML1821c ML1821c conserved hypothetical protein ML1821c, len: 117 aa. Conserved hypothetical protein. Similar to the C-terminal region of Q8GE87 Hypothetical protein from M. avium (186 aa), fasta scores: E(): 2.5e-09, (66.667% identity in 48 aa overlap). Homology to Q8GE87 continues downstream of this ORF in a different frame suggesting a possible frameshift. Q9CBL0 No conserved hypotheticals Q9CBL0 AL450380.2 Mycobrowser_v4 CDS 1136539 1136664 . + 0 ML0967A ML0967A hypothetical protein(pseudogene) ML0967A, len:125. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1996143 1997420 . + 0 ML1656 kasB INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC ACIDS SYNTHESIS); INVOLVED IN MEROMYCOLATE EXTENSION. CATALYZES THE CONDENSATION REACTION OF FATTY ACID SYNTHESIS BY THE ADDITION TO AN ACYL ACCEPTOR OF TWO CARBONS FROM MALONYL-ACP [CATALYTIC ACTIVITY: ACYL-[ACYL-CARRIER PROTEIN] + MALONYL-[ACYL-CARRIER PROTEIN] = 3-OXOACYL-[ACYL-CARRIER PROTEIN] + [ACYL-CARRIER PROTEIN] + CO(2)]. 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) ML1656, len: 425 aa. Probable kasB, 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41). Highly similar to many 3-oxoacyl-[acyl-carrier-protein] synthases II involved in fatty acid biosynthesis including: Escherichia coli SW:FABF_ECOLI (P39435) (412 aa), Fasta scores: E(): 0, 36.2% identity in 409 aa overlap and Mycobacterium tuberculosis Rv2246 SW:FAB2_MYCTU (Q10525) (438 aa), Fasta scores: E(): 0, 90.8% identity in 423 aa overlap. Also highly similar to the adjoining CDS ML1655. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. O69473 No lipid metabolism PF00109,PF02801 O69473 GO:0005737,GO:0006633,GO:0004315 2.3.1.41 Rv2246 Rv2246 AL450380.2 Mycobrowser_v4 CDS 2000901 2001617 . - 0 ML1659c rnc PROBABLE RIBONUCLEASE III RNC (RNASE III) ML1659c, len: 238 aa. Probable rnc, Ribonuclease III (EC 3.1.26.3). Highly similar to many ribonucleases involved in the digestion of double stranded RNA e.g. Escherichia coli SW:RNC_ECOLI (P05797) (226 aa), Fasta scores: E(): 1e-24, 41.8% identity in 213 aa overlap and Mycobacterium tuberculosis Rv2925c SW:RNC_MYCTU (Q10962) (240 aa), Fasta scores: E(): 0, 86.8% identity in 235 aa overlap. Contains Pfam match to entry PF00035 dsrm, Double-stranded RNA binding motif. Contains Pfam match to entry PF00636 Ribonuclease_3, RNase3 domain.. Contains PS00517 Ribonuclease III family signature. O69469 No information pathways PF00035,PF00636 O69469 GO:0003725,GO:0006397,GO:0016075,GO:0006364,GO:0004525,GO:0005737 3.1.26.3 Rv2925c Rv2925c AL450380.2 Mycobrowser_v4 CDS 2029540 2030136 . - 0 ML1684c leuD PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) LEUD (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) ML1684c, len: 198 aa. Probable leuD, 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33). Highly similar to many 3-isopropylmalate dehydratase small subunits involved in leucine biosynthesis, including: Escherichia coli SW:LEUD_ECOLI (P30126) (201 aa), Fasta scores: E(): 1.2e-28, 42.1% identity in 197 aa overlap and Mycobacterium tuberculosis Rv2987c SW:LEUD_MYCTU (O53236) (198 aa), Fasta scores: E(): 0, 87.8% identity in 196 aa overlap. Contains Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain. O33124 No intermediary metabolism and respiration PF00694 O33124 GO:0009316,GO:0009098,GO:0003861 4.2.1.33 Rv2987c Rv2987c AL450380.2 Mycobrowser_v4 CDS 2024688 2025338 . + 0 ML1680 ML1680 conserved hypothetical protein ML1680, len: 216 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis Rv2983 TR:P95112 (EMBL:Z83018) (214 aa), Fasta scores: E(): 0, 79.1% identity in 215 aa overlap and Streptomyces coelicolor TR:Q9ZBS2 (EMBL:AL034447) (212 aa), Fasta scores: E(): 1.2e-17, 41.1% identity in 207 aa overlap. Contains Pfam match to entry PF01983 DUF121, Protein of unknown function. O33128 No conserved hypotheticals PF01983 O33128 Rv2983 Rv2983 AL450380.2 Mycobrowser_v4 CDS 2035096 2035824 . - 0 ML1689c ML1689c POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE) ML1689c, len: 242 aa. Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-). Similar to several putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerases including: Methanobacterium thermoautotrophicum TR:O27551 (EMBL:AE000911) (260 aa), Fasta scores: E(): 0, 51.9% identity in 216 aa overlap and Mycobacterium tuberculosis Rv2993c TR:O53242 (EMBL:AL021287) (239 aa), Fasta scores: E(): 0, 85.9% identity in 241 aa overlap. Contains Pfam match to entry PF01557 FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family. Q7AQ28 No intermediary metabolism and respiration PF01557,PF10370 Q7AQ28 GO:0008152,GO:0016787 Rv2993c Rv2993c AL450380.2 Mycobrowser_v4 CDS 2042727 2043728 . - 0 ML1694c ilvC PROBABLE KETOL-ACID REDUCTOISOMERASE ILVC (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase) ML1694c, len: 333 aa. Probable ilvC, ketol-acid reductoisomerase (EC1.1.1.86 ). Highly similar to many ketol-acid reductoisomerases involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVC_MYCAV (Q59500) (333 aa), Fasta scores: E(): 0, 89.2% identity in 333 aa overlap and Mycobacterium tuberculosis Rv3001c SW:ILVC_MYCTU (O53248) (333 aa), Fasta scores: E(): 0, 86.2% identity in 333 aa overlap. Contains Pfam match to entry PF01450 IlvC, Acetohydroxy acid isomeroreductase. O33114 No intermediary metabolism and respiration PF01450,PF07991 O33114 GO:0009097,GO:0004455,GO:0055114,GO:0009099,GO:0005488 1.1.1.86 Rv3001c Rv3001c AL450380.2 Mycobrowser_v4 CDS 2050127 2051656 . - 0 ML1700c gatB COMPONENT OF THE TRANSLATIONAL APPARATUS. FURNISHES A MEANS FOR FORMATION OF CORRECTLY CHARGED GLN-TRNA(GLN) THROUGH THE TRANSAMIDATION OF MISACYLATED GLU- TRNA(GLN) IN ORGANISMS WHICH LACK GLUTAMINYL-TRNA SYNTHETASE. THE REACTION TAKES PLACE IN THE PRESENCE OF GLUTAMINE AND ATP THROUGH AN ACTIVATED GAMMA-PHOSPHO-GLU-TRNA(GLN) [CATALYTIC ACTIVITY: ATP + L-GLUTAMYL-TRNA(GLN) + L-GLUTAMINE = ADP + PHOSPHATE + L-GLUTAMINYL-TRNA(GLN) + L-GLUTAMATE]. PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT B) GATB (Glu-ADT SUBUNIT B) ML1700c, len: 509 aa. Probable gatB, glutamyl-tRNA(Gln) amidotransferase, subunit B (EC 6.3.5.-). Highly similar to many glutamyl-tRNA(Gln) amidotransferases (subunit B) including: Bacillus subtilis SW:GATB_BACSU (O30509) (269 aa), BlastP Expect 8.6 and Mycobacterium tuberculosis Rv3009c SW:GATB_MYCTU (O53256) (509 aa), Fasta scores: E(): 0, 88.4% identity in 509 aa overlap. Contains Pfam match to entry PF01162 PET112, PET112 family. Contains PS01234 PET112 family signature. O33107 No information pathways PF01162,PF02637,PF02934 O33107 GO:0050567,GO:0006412,GO:0005524 6.3.5.- Rv3009c Rv3009c AL450380.2 Mycobrowser_v4 CDS 2052005 2053036 . - 0 ML1701c pfkA PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) ML1701c, len: 343 aa. Probable pfkA, 6-phosphofructokinase (EC 2.7.1.11). Highly similar to many 6-phosphofructokinases including: Streptomyces coelicolor SW:K6PF_STRCO (O08333) (342 aa), Fasta scores: E(): 0, 56.5% identity in 345 aa overlap and Mycobacterium tuberculosis Rv3010c SW:K6PF_MYCTU (O53257) (343 aa), Fasta scores: E(): 0, 90.4% identity in 343 aa overlap. Contains 2 Pfam matches to entry PF00365 PFK, Phosphofructokinase. Contains PS00433 Phosphofructokinase signature. O33106 No intermediary metabolism and respiration PF00365 O33106 GO:0005945,GO:0005524,GO:0006002,GO:0006096,GO:0000287,GO:0003872 2.7.1.11 Rv3010c Rv3010c AL450380.2 Mycobrowser_v4 CDS 2188475 2189482 . - 0 ML1808c ML1808c PROBABLE CONSERVED MEMBRANE PROTEIN ML1808c, len: 335 aa. Probable membrane protein. Similar to M. tuberculosis Rv1481 SW:YE81_MYCTU (P71762) (335 aa), Fasta scores: E(): 0, 91.0% identity in 335 aa overlap. Contains Pfam match to entry PF00092 vwa, von Willebrand factor type A domain. Similar to ML0701 from M. leprae. Q9CBL9 No cell wall and cell processes PF00092 Q9CBL9 GO:0005886,GO:0016021 Rv1481 Rv1481 AL450380.2 Mycobrowser_v4 CDS 2055751 2057835 . - 0 ML1705c ligA THIS PROTEIN CATALYZES THE FORMATION OF PHOSPHODIESTER LINKAGES BETWEEN 5'-PHOSPHORYL AND 3'-HYDROXYL GROUPS IN DOUBLE-STRANDED DNA USING NAD AS A COENZYME AND AS THE ENERGY SOURCE FOR THE REACTION. IT IS ESSENTIAL FOR DNA REPLICATION AND REPAIR OF DAMAGED DNA [CATALYTIC ACTIVITY: NAD(+) + (DEOXYRIBONUCLEOTIDE)(N) + (DEOXYRIBONUCLEOTIDE)(M) = AMP + NICOTINAMIDE NUCLEOTIDE + (DEOXYRIBONUCLEOTIDE)(N+M)]. PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) ML1705c, len: 694 aa. Probable ligA, DNA ligase (EC 6.5.1.2). Highly similar to many DNA ligases essential for DNA replication and repair, including: DNLJ_ECOLI and Mycobacterium tuberculosis Rv3014c SW:DNLJ_MYCTU (O53261) (691 aa), Fasta scores: E(): 0, 84.7% identity in 687 aa overlap. Contains Pfam match to entry PF01653 DNA_ligase_N, NAD-dependent DNA ligase. Contains Pfam match to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain. Contains PS01055 NAD-dependent DNA ligase signature 1. O33102 No information pathways PF00533,PF00633,PF01653,PF03119,PF03120 O33102 GO:0003911,GO:0006281,GO:0006260,GO:0005622,GO:0000287,GO:0030145,GO:0008270,GO:0003677 6.5.1.2 Rv3014c Rv3014c AL450380.2 Mycobrowser_v4 CDS 2080798 2081556 . - 0 ML1724c echA17 PROBABLE ENOYL-CoA HYDRATASE ECHA17 (CROTONASE) (UNSATURED ACYL-CoA HYDRATASE) (ENOYL HYDRASE) ML1724c, len: 252 aa. Probable echA17, enoyl-CoA hydratase (EC 4.2.1.17). Similar to several proposed enoyl-CoA hydratases including: Rhizobium meliloti SW:ECHH_RHIME (Q52995) (257 aa), Fasta scores: E(): 1.8e-19, 34.7% identity in 225 aa overlap, Clostridium acetobutylicum SW:CRT_CLOAB (P52046) (261 aa), Fasta scores: E(): 1.7e-17, 27.9% identity in 240 aa overlap and Mycobacterium tuberculosis Rv3039c TR:O53286 (EMBL:AL021287) (254 aa), Fasta scores: E(): 0, 85.6% identity in 243 aa overlap. Also similar to ML2402 from M. leprae. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Q9CBQ8 No lipid metabolism PF00378 Q9CBQ8 GO:0008152,GO:0016853 Rv3039c Rv3039c AL450380.2 Mycobrowser_v4 CDS 2086569 2087663 . + 0 ML1729 fecB PROBABLE FEIII-DICITRATE-BINDING PERIPLASMIC LIPOPROTEIN FECB ML1729, len: 364 aa. Probable fecB, FeIII dicitrate-binding periplasmic lipoprotein. Highly similar to several proteins involved in iron transport including: Mycobacterium avium FecB precursor TR:AAF73189 (EMBL:AF151098) (364 aa), Fasta scores: E(): 0, 67.4% identity in 362 aa overlap and Mycobacterium tuberculosis Rv3044 TR:O53291 (EMBL:AL021287) (359 aa), Fasta scores: E(): 0, 75.6% identity in 357 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CBQ4 No cell wall and cell processes PF01497 Q9CBQ4 GO:0005381,GO:0006827 Rv3044 Rv3044 AL450380.2 Mycobrowser_v4 CDS 2158331 2159152 . - 0 ML1782c ML1782c conserved hypothetical protein ML1782c, len: 273 aa. Conserved hypothetical protein. Similar to M. tuberculosis Rv2257c TR:O53531 (EMBL:AL021925) (272 aa), Fasta scores: E(): 0, 76.4% identity in 271 aa overlap, and to Streptomyces coelicolor SC4A7.08 TR:Q9RDQ4 (EMBL:AL133423) (273 aa), Fasta scores: E(): 0, 53.2% identity in 269 aa overlap. Q9CBN4 No conserved hypotheticals PF00144 Q9CBN4 Rv2257c Rv2257c AL450380.2 Mycobrowser_v4 CDS 2191853 2192578 . - 0 ML1811c ML1811c HYPOTHETICAL INVASION PROTEIN ML1811c, len: 241 aa. Hypothetical Invasion protein, possibly exported protein. Similar to M. tuberculosis Rv1478 TR:O53169 (EMBL:AL021184) (241 aa), Fasta scores: E(): 0, 77.1% identity in 240 aa overlap, and to Listeria innocua protein p60 precursor (invasion-associated protein) SW:P60_LISIN (Q01836) (481 aa), Fasta scores: E(): 4.2e-07, 31.0% identity in 200 aa overlap. Also similar to ML1812, ML1214 and ML0885 from M. leprae. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Q9CBL6 No virulence, detoxification, adaptation PF00877 Q9CBL6 Rv1478 Rv1478 AL450380.2 Mycobrowser_v4 CDS 2174304 2174750 . + 0 ML1795 hsp18 18 KDA antigen Hsp18 (HSP 16.7) ML1795, len: 148 aa. hsp18, 18 KDA antigen. Highly similar to other mycobacterial antigens e.g. 18K1_MYCIT|P46730 18 kDa antigen 1 from Mycobacterium intracellulare (149 aa), Fasta scores: E(): 0, (78.7% identity in 150 aa overlap), and small heat shock proteins e.g. HS18_STRAL|Q53595 hsp18 from Streptomyces albus (143 aa), Fasta scores: E(): 4.1e-26, (55.0% identity in 140 aa overlap). Previously sequenced as 18KD_MYCLE|P12809 (148 aa), Fasta scores: E(): 0, 100.0% identity in 148 aa overlap. Contains Pfam match to entry PF00011 HSP20, Hsp20/alpha crystallin family. Belongs to the small heat shock protein (HSP20) family. P12809 No virulence, detoxification, adaptation PF00011 P12809 AL450380.2 Mycobrowser_v4 CDS 2165627 2166004 . - 0 ML1791c ML1791c conserved hypothetical protein ML1791c, len: 125 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv1976c TR:O53977 (EMBL:AL022073) (135 aa), Fasta scores: E(): 3.5e-28, 65.3% identity in 124 aa overlap, and to Streptomyces coelicolor hypothetical protein SC1C3.03C TR:O69845 (EMBL:AL023702) (125 aa), Fasta scores: E(): 4.3e-06, 36.6% identity in 112 aa overlap. Note start changed since original submission. Q9CBN1 No conserved hypotheticals Q9CBN1 Rv1976c Rv1976c AL450380.2 Mycobrowser_v4 CDS 2184852 2185748 . + 0 ML1804 ML1804 conserved hypothetical protein ML1804, len: 298 aa. Conserved hypothetical protein. Similar to M. tuberculosis Rv1486c SW:YE86_MYCTU (P71766) (288 aa), Fasta scores: E(): 5.1e-25, 76.7% identity in 300 aa overlap, and to Mycobacterium avium hypothetical protein MAV321 SW:YE86_MYCAV (O07402) (320 aa), Fasta scores: E(): 0, 62.9% identity in 315 aa overlap. Q9CBM3 No conserved hypotheticals Q9CBM3 Rv1486c Rv1486c AL450380.2 Mycobrowser_v4 CDS 2177910 2180186 . - 0 ML1799c mutB PROBABLE METHYLMALONYL-CoA MUTASE LARGE SUBUNIT MUTB (MCM) ML1799c, len: 758 aa. Probable mutB, methylmalonyl-CoA mutase (EC 5.4.99.2). Similar to M. tuberculosis mutB Rv1493 SW:MUTB_MYCTU (P71774) (750 aa), Fasta scores: E(): 0, 88.9% identity in 748 aa overlap, and many other methylmalonyl-CoA mutase alpha-subunit e.g. Streptomyces cinnamonensis SW:MUTB_STRCM (Q05065) (733 aa), Fasta scores: E(): 0, 74.7% identity in 726 aa overlap. Also similar to ML1800. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature. Q9CBM7 No lipid metabolism PF01642,PF02310 Q9CBM7 GO:0008152,GO:0046872,GO:0004494,GO:0031419 Rv1493 Rv1493 AL450380.2 Mycobrowser_v4 CDS 2185785 2186795 . - 0 ML1805c hemZ FERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME SYNTHETASE) ML1805c, len: 336 aa. Probable hemZ, ferrochelatase (EC 4.99.1.1). Similar to M. tuberculosis hemZ Rv1485 SW:HEMZ_MYCTU (P71765) (344 aa), Fasta scores: E(): 0, 76.8% identity in 336 aa overlap, and to many others e.g. Propionibacterium freudenreichii shermanii ferrochelatase SW:HEMZ_PROFR (P72183) (352 aa), Fasta scores: E(): 0, 38.9% identity in 311 aa overlap. Contains Pfam match to entry PF00762 Ferrochelatase, Ferrochelatase. Contains PS00534 Ferrochelatase signature. Q9CBM2 No intermediary metabolism and respiration PF00762 Q9CBM2 GO:0004325,GO:0006783,GO:0005506,GO:0005737 4.99.1.1 Rv1485 Rv1485 AL450380.2 Mycobrowser_v4 CDS 2192605 2194044 . - 0 ML1812c ML1812c HYPOTHETICAL INVASION PROTEIN ML1812c, len: 479 aa. Hypothetical Invasion protein. Possibly exported protein with unusually long signal sequence. Similar to M. tuberculosis Rv1477 TR:O53168 (EMBL:AL021184) (472 aa), Fasta scores: E(): 0, 78.8% identity in 480 aa overlap and to Listeria innocua protein p60 precursor (invasion-associated protein) SW:P60_LISMO (P21171) (484 aa), Fasta scores: E(): 1e-06, 23.8% identity in 491 aa overlap. Also similar to ML1811, ML1214 and ML0885 from M. leprae. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Q9CBL5 No virulence, detoxification, adaptation PF00877 Q9CBL5 Rv1477 Rv1477 AL450380.2 Mycobrowser_v4 CDS 2231936 2232499 . - 0 ML1847c rplE PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE ML1847c, len: 187 aa. Probable rplE, 50S ribosomal protein L5. Similar to M. tuberculosis 50S ribosomal protein L5 Rv0716 SW:RL5_MYCTU (P95064) (187 aa), Fasta scores: E(): 0, 91.4% identity in 187 aa overlap. Contains Pfam match to entry PF00281 Ribosomal_L5, Ribosomal protein L5. Contains Pfam match to entry PF00673 Ribosomal_L5_C, ribosomal L5P family C-terminus. O32995 No information pathways PF00281,PF00673 O32995 GO:0005840,GO:0003735,GO:0000049,GO:0006412,GO:0019843 Rv0716 Rv0716 AL450380.2 Mycobrowser_v4 CDS 2230699 2231238 . - 0 ML1844c rplF PROBABLE 50S RIBOSOMAL PROTEIN L6 RPLF ML1844c, len: 179 aa. Probable rplF, 50S ribosomal protein L6. Similar to M. tuberculosis 50S ribosomal protein L6 Rv0719 SW:RL6_MYCTU (P95067) (179 aa), Fasta scores: E(): 0, 90.5% identity in 179 aa overlap. Contains Pfam match to entry PF00347 Ribosomal_L6, Ribosomal protein L6. Contains PS00525 Ribosomal protein L6 signature 1. O32998 No information pathways PF00347 O32998 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0719 Rv0719 AL450380.2 Mycobrowser_v4 CDS 2232500 2232817 . - 0 ML1848c rplX PROBABLE 50S RIBOSOMAL PROTEIN L24 RPLX ML1848c, len: 105 aa. Probable rplX, 50S ribosomal protein L24. Similar to M. tuberculosis 50S ribosomal protein L24 Rv0715 SW:RL24_MYCTU (P95063) (105 aa), Fasta scores: E(): 0, 93.3% identity in 105 aa overlap. Contains Pfam match to entry PF00467 Ribosomal_L24, KOW motif. Contains PS01108 Ribosomal protein L24 signature. O32994 No information pathways PF00467 O32994 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0715 Rv0715 AL450380.2 Mycobrowser_v4 CDS 2239398 2240243 . - 0 ML1857c rpsC PROBABLE 30S RIBOSOMAL PROTEIN S3 RPSC ML1857c, len: 281 aa. Probable rpsC, 30S ribosomal protein S3. Similar to M. tuberculosis 30S ribosomal protein S3 Rv0707 SW:RS3_MYCTU (P95055) (273 aa), Fasta scores: E(): 0, 95.0% identity in 259 aa overlap. Contains Pfam match to entry PF00417 Ribosomal_S3_N, Ribosomal protein S3, N-terminal domain.. Contains Pfam match to entry PF00013 KH-domain, KH domain. Contains Pfam match to entry PF00189 Ribosomal_S3_C, Ribosomal protein S3, C-terminal domain. Contains PS00548 Ribosomal protein S3 signature. O32987 No information pathways PF00189,PF00417,PF07650 O32987 GO:0015935,GO:0003735,GO:0006412,GO:0019843 Rv0707 Rv0707 AL450380.2 Mycobrowser_v4 CDS 2238356 2238739 . - 0 ML1854c rpsQ PROBABLE 30S RIBOSOMAL PROTEIN S17 RPSQ ML1854c, len: 127 aa. Probable rpsQ, 30S ribosomal protein S17. Similar to M. tuberculosis 30S ribosomal protein S17 Rv0710 SW:RS17_MYCTU (P95058) (136 aa), Fasta scores: E(): 1.5e-29, 77.2% identity in 136 aa overlap. Contains Pfam match to entry PF00366 Ribosomal_S17, Ribosomal protein S17. Contains PS00056 Ribosomal protein S17 signature. O32990 No information pathways PF00366 O32990 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0710 Rv0710 AL450380.2 Mycobrowser_v4 CDS 2240767 2241048 . - 0 ML1859c rpsS PROBABLE 30S RIBOSOMAL PROTEIN S19 RPSS ML1859c, len: 93 aa. Probable rpsS, 30S ribosomal protein S19. Similar to M. tuberculosis 30S ribosomal protein S19 Rv0705 SW:RS19_MYCTU (P48947) (93 aa), Fasta scores: E(): 0, 96.8% identity in 93 aa overlap. Contains Pfam match to entry PF00203 Ribosomal_S19, Ribosomal protein S19. Contains PS00323 Ribosomal protein S19 signature. O32985 No information pathways PF00203 O32985 GO:0015935,GO:0003735,GO:0006412,GO:0019843 Rv0705 Rv0705 AL450380.2 Mycobrowser_v4 CDS 2259295 2259765 . - 0 ML1879c rpsG PROBABLE 30S RIBOSOMAL PROTEIN S7 RPSG ML1879c, len: 156 aa. Probable rpsG, 30S ribosomal protein S7. Similar to Mycobacterium tuberculosis 30s ribosomal protein S7 rpsG or rps7 or Rv0683 or MTV040.11 SW:RS7_MYCTU (P41194) (155 aa) fasta scores: E(): 0, 98.1% identity in 155 aa and to Mycobacterium smegmatis 30s ribosomal protein S7 rpsG SW:RS7_MYCSM (P41193) (155 aa) fasta scores: E(): 0, 95.5% identity in 155 aa. Previously sequenced as SW:RS7_MYCLE (P30764). Contains Pfam match to entry PF00177 Ribosomal_S7, Ribosomal protein S7p/S5e. Contains PS00052 Ribosomal protein S7 signature. P30764 No information pathways PF00177 P30764 GO:0015935,GO:0003735,GO:0000049,GO:0006412,GO:0019843 Rv0683 Rv0683 AL450380.2 Mycobrowser_v4 CDS 2259765 2260139 . - 0 ML1880c rpsL PROBABLE 30S RIBOSOMAL PROTEIN S12 RPSL ML1880c, len: 124 aa. Probable rpsL, 30S ribosomal protein S12. Similar to M. tuberculosis 30S ribosomal protein S12 RPS12 SW:RS12_MYCTU (P41196) (124 aa), Fasta scores: E(): 0, 97.6% identity in 123 aa overlap. Contains Pfam match to entry PF00164 Ribosomal_S12, Ribosomal protein S12. Contains PS00055 Ribosomal protein S12 signature. P30766 No information pathways PF00164 P30766 GO:0015935,GO:0003735,GO:0000049,GO:0006412,GO:0019843 Rv0682 Rv0682 AL450380.2 Mycobrowser_v4 CDS 2282295 2283641 . + 0 ML1898 ML1898 conserved hypothetical protein ML1898, len: 448 aa. Conserved hypothetical protein. Similar to M. tuberculosis conserved hypothetical protein Rv0647c SW:Y647_MYCTU (P96936) (488 aa), Fasta scores: E(): 0, 85.3% identity in 448 aa overlap, and to others e.g. Synechocystis sp. SW:YH70_SYNY3 (P73627) (585 aa), Fasta scores: E(): 0, 30.9% identity in 401 aa overlap. Also similar to ML0640 from M. leprae. Q9CBK6 No conserved hypotheticals PF03109 Q9CBK6 GO:0006468,GO:0004672,GO:0005524 Rv0647c Rv0647c AL450380.2 Mycobrowser_v4 CDS 1139611 1139733 . - 0 ML0970A ML0970A hypothetical protein(pseudogene) ML0970A, len:122. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2291611 2292297 . - 0 ML1906c nusG PROBABLE TRANSCRIPTION ANTITERMINATION PROTEIN NUSG ML1906c, len: 228 aa. Probable nusG, transcription antitermination protein. Similar to M. tuberculosis transcription antitermination protein nusG Rv0639 TR:P96930 (EMBL:Z92772) (238 aa), Fasta scores: E(): 0, 93.4% identity in 211 aa overlap, and to many others e.g. Streptomyces griseus. Contains PS01014 Transcription termination factor nusG signature. Q9CBK0 No information pathways PF00467,PF02357 Q9CBK0 GO:0031564,GO:0003711,GO:0006353,GO:0032968 Rv0639 Rv0639 AL450380.2 Mycobrowser_v4 CDS 2291155 2291583 . - 0 ML1905c rplK PROBABLE 50S RIBOSOMAL PROTEIN L11 RPLK ML1905c, len: 142 aa. Probable rplK, 50S ribosomal protein L11. Similar to M. tuberculosis 50S ribosomal protein L11 Rv0640 SW:RL11_MYCTU (P96931) (142 aa), Fasta scores: E(): 0, 92.3% identity in 142 aa overlap. Contains Pfam match to entry PF00298 Ribosomal_L11, Ribosomal protein L11. Contains PS00359 Ribosomal protein L11 signature. Q9CBK1 No information pathways PF00298,PF03946 Q9CBK1 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0640 Rv0640 AL450380.2 Mycobrowser_v4 CDS 2293151 2293651 . - 0 ML1908c ML1908c conserved hypothetical protein ML1908c, len: 166 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv0637 TR:P96928 (EMBL:Z92772) (166 aa), Fasta scores: E(): 0, 88.6% identity in 166 aa overlap, and to others e.g. Streptomyces coelicolor SCD82.07 TR:CAB77410 (EMBL:AL160431) (150 aa), Fasta scores: E(): 4.7e-11, 29.3% identity in 150 aa overlap. Also similar to ML1910 and ML2425 from M. leprae. Q9CBJ8 No conserved hypotheticals, intermediary metabolism and respiration Q9CBJ8 Rv0637 Rv0637 AL450380.2 Mycobrowser_v4 CDS 2071252 2071353 . + 0 ML1716A ML1716A hypothetical protein(pseudogene) ML1716A, len:101. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-08 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2312099 2312407 . - 0 ML1927c ML1927c conserved hypothetical protein ML1927c, len: 102 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv0430 TR:P96276 (EMBL:Z84724) (102 aa), Fasta scores: E(): 0, 93.1% identity in 102 aa overlap, and to Streptomyces coelicolor hypothetical protein SCD95A.20 TR:CAB93047 (EMBL:AL357432) (84 aa), Fasta scores: E(): 4.1e-11, 52.8% identity in 72 aa overlap. Q9CBI4 No conserved hypotheticals Q9CBI4 Rv0430 Rv0430 AL450380.2 Mycobrowser_v4 CDS 2303412 2304305 . + 0 ML1920 mutY PROBABLE ADENINE GLYCOSYLASE MUTY ML1920, len: 297 aa. Probable mutY, DNA glycosylase (EC 3.2.2.-). Similar to M. tuberculosis probable DNA glycosylase Rv3589 TR:O53574 (EMBL:AL022075) (304 aa), Fasta scores: E(): 0, 74.9% identity in 303 aa overlap, and to many others e.g. Escherichia coli A/G-specific adenine glycosylase mutY SW:MUTY_ECOLI (P17802) (350 aa), Fasta scores: E(): 1.8e-21, 33.2% identity in 244 aa overlap. Also similar to ML2301 from M. leprae. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III. Q9CBJ0 No information pathways PF00730,PF10576 Q9CBJ0 GO:0006284,GO:0004519,GO:0051539 Rv3589 Rv3589 AL450380.2 Mycobrowser_v4 CDS 2336696 2337571 . - 0 ML1950c ML1950c POSSIBLE GLYCOSYL HYDROLASE ML1950c, len: 291 aa. Possible glycosyl hydrolase (EC 3.-.-.-), possibly deacetylase or esterase. Similar to M. tuberculosis Rv1096 TR:O53444 (EMBL:AL021897) glycosyl hydrolase (291 aa), Fasta scores: E(): 0, 81.3% identity in 289 aa overlap, and to Streptomyces lividans acetylxylan esterase precursor TR:Q54413 (EMBL:M64552) (335 aa), Fasta scores: E(): 2.8e-18, 31.8% identity in 236 aa overlap. Also similar to ML2649 from M. leprae. Contains Pfam match to entry PF01522 Polysac_deacet, Polysaccharide deacetylase. Q7AQ13 No intermediary metabolism and respiration PF01522 Q7AQ13 GO:0016810,GO:0005975 Rv1096 Rv1096 AL450380.2 Mycobrowser_v4 CDS 1150655 1151052 . + 0 ML0983A ML0983A hypothetical protein(pseudogene) ML0983A, len:397. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-15 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2341570 2342508 . + 0 ML1954 coaA Probable pantothenate kinase CoaA (Pantothenic acid kinase) ML1954, len: 312 aa. Probable coaA, pantothenate kinase (EC 2.7.1.33). Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa), Fasta scores: E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa), Fasta scores: E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9X795 No intermediary metabolism and respiration Q9X795 GO:0015937,GO:0005737,GO:0004594,GO:0005524 2.7.1.33 Rv1092c Rv1092c AL450380.2 Mycobrowser_v4 CDS 2343336 2344085 . - 0 ML1955c truA PROBABLE TRNA PSEUDOURIDINE SYNTHASE A TRUA (PSEUDOURIDYLATE SYNTHASE I) (PSEUDOURIDINE SYNTHASE I) (URACIL HYDROLYASE) ML1955c, len: 249 aa. Probable truA, tRNA pseudouridine synthase A (EC 4.2.1.70). Similar to M. tuberculosis probable pseudouridylate synthase truA Rv3455c SW:TRUA_MYCTU (Z95390) (256 aa), Fasta scores: E(): 0, 77.2% identity in 246 aa overlap, and to many others e.g Pseudomonas aeruginosa tRNA pseudouridine synthase A SW:TRUA_PSEAE (O87016) (285 aa), Fasta scores: E(): 4.2e-16, 34.3% identity in 242 aa overlap. Contains Pfam match to entry PF01416 PseudoU_synth_1, tRNA pseudouridine synthase. Q9X796 No information pathways PF01416 Q9X796 GO:0031119,GO:0009982 5.4.99.12 Rv3455c Rv3455c AL450380.2 Mycobrowser_v4 CDS 2347604 2347825 . - 0 ML1962c infA PROBABLE TRANSLATION INITIATION FACTOR IF-1 INFA ML1962c, len: 73 aa. Probable infA, translation initiation factor IF-1. Similar to M. tuberculosis initiation factor IF-1 infA Rv3462c SW:IF1_MYCTU (P45957) (72 aa), Fasta scores: E(): 9.6e-30, 100.0% identity in 72 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain. P0A5H7 No information pathways PF01176 P0A5H7 GO:0005737,GO:0003743,GO:0006413,GO:0003723 Rv3462c Rv3462c AL450380.2 Mycobrowser_v4 CDS 2345841 2346446 . - 0 ML1958c rpsD PROBABLE 30S RIBOSOMAL PROTEIN S4 RPSD ML1958c, len: 201 aa. Probable rpsD, 30S ribosomal protein S4. Similar to M. tuberculosis 30S ribosomal protein S4 rpsD Rv3458c SW:RS4_MYCTU (O06325) (201 aa), Fasta scores: E(): 0, 93.5% identity in 201 aa overlap. Contains Pfam match to entry PF00163 Ribosomal_S4, Ribosomal protein S4/S9 N-terminal domain. Contains Pfam match to entry PF01479 S4, S4 domain. Contains PS00632 Ribosomal protein S4 signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9X799 No information pathways PF00163,PF01479 Q9X799 GO:0015935,GO:0003735,GO:0006412,GO:0019843 Rv3458c Rv3458c AL450380.2 Mycobrowser_v4 CDS 2346480 2346896 . - 0 ML1959c rpsK PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK ML1959c, len: 138 aa. Probable rpsK, 30S ribosomal protein S11. Similar to M. tuberculosis 30S ribosomal protein S11 rpsK Rv3459c SW:RS11_MYCTU (O06326) (139 aa), Fasta scores: E(): 0, 89.9% identity in 139 aa overlap. Contains Pfam match to entry PF00411 Ribosomal_S11, Ribosomal protein S11. Contains PS00054 Ribosomal protein S11 signature. Q9X7A0 No information pathways PF00411 Q9X7A0 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv3459c Rv3459c AL450380.2 Mycobrowser_v4 CDS 2420654 2421127 . + 0 ML2030 rpfC PROBABLE RESUSCITATION-PROMOTING FACTOR RPFC ML2030, len: 157 aa. Probable rpfC, resuscitation promoting factor. Similar to Mycobacterium tuberculosis resuscitation promoting factors: rpfC, Rv1884c TR:O07747 (EMBL:Z97193) fasta scores: E(): 0, 70.2% in 141 aa and rpfD TR:P71755 Rv2389c (EMBL:Z81368) fasta scores: E(): 2.8e-20, 47.9% in 121 aa. Also similar to ML2151 and ML0240 from M. leprae. Q9CBF8 No cell wall and cell processes PF06737 Q9CBF8 GO:0005576 Rv1884c Rv1884c AL450380.2 Mycobrowser_v4 CDS 1258677 1258826 . - 0 ML1093A ML1093A hypothetical protein(pseudogene) ML1093A, len:149. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.001 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2373434 2375734 . + 0 ML1987 ctpA PROBABLE CATION TRANSPORTER P-TYPE ATPASE A CTPA ML1987, len: 766 aa. Probable ctpA, cation-transporter P-type ATPase A (EC 3.6.3.-). Similar to Mycobacterium tuberculosis cation-transporting P-type ATPase A ctpA or Rv0092 or MTCY251.11 SW:CTPA_MYCTU (Q10876) (761 aa) fasta scores: E(): 0, 77.2% identity in 715 aa. Previously sequenced as SW:CTPA_MYCLE (P46839). Also similar to ML0747 and ML2000 from M. leprae. Contains multiple possible membrane spanning hydrophobic domains and Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase. Contains PS00154 E1-E2 ATPases phosphorylation site. P46839 No cell wall and cell processes PF00122,PF00702 P46839 GO:0006754,GO:0004008,GO:0016021,GO:0000287,GO:0030001,GO:0005886,GO:0005524 3.6.3.- Rv0092 Rv0092 AL450380.2 Mycobrowser_v4 CDS 2380056 2380925 . + 0 ML1992 ML1992 POSSIBLE OXIDOREDUCTASE ML1992, len: 289 aa. Possible oxidoreductase. Similar to M. tuberculosis possible oxidoreductase Rv0097 SW:Y097_MYCTU (Q10893) (289 aa), Fasta scores: E(): 0, 76.4% identity in 288 aa overlap, and to Escherichia coli alpha-ketoglutarate-dependent taurine dioxygenase SW:TAUD_ECOLI (P37610) (282 aa), Fasta scores: E(): 2.6e-10, 24.5% identity in 278 aa overlap. Q9CBG4 No intermediary metabolism and respiration PF02668 Q9CBG4 GO:0016491,GO:0009055 Rv0097 Rv0097 AL450380.2 Mycobrowser_v4 CDS 2383094 2383330 . + 0 ML1995 ML1995 conserved hypothetical protein ML1995, len: 78 aa. Conserved hypothetical protein. Similar to M. tuberculosis hypothetical protein Rv0100 SW:Y100_MYCTU (Q10895) (78 aa), Fasta scores: E(): 1.1e-18, 69.0% identity in 71 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Q9CBG2 No conserved hypotheticals PF00550 Q9CBG2 GO:0048037 Rv0100 Rv0100 AL450380.2 Mycobrowser_v4 CDS 2387539 2388171 . - 0 ML1997c ML1997c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN ML1997c, len: 210 aa. Probable conserved integral membrane protein. Similar to M. tuberculosis probable integral membrane protein Rv0970 SW:Y970_MYCTU (P71541) (210 aa), Fasta scores: E(): 0, 52.1% identity in 213 aa overlap, and to Streptomyces coelicolor putative integral membrane protein SCM2.15C. Contains multiple possible membrane spanning hydrophobic domains. Q9CBG1 No cell wall and cell processes Q9CBG1 Rv0970 Rv0970 AL450380.2 Mycobrowser_v4 CDS 2383327 2387532 . + 0 ML1996 nrp POSSIBLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) ML1996, len: 1401 aa. Possible nrp, peptide synthase. Similar in N-terminus to M. tuberculosis probable peptide synthetase nrp Rv0101 TR:Q10896 (EMBL:Z74410) (2512 aa), Fasta scores: E(): 0, 65.7% identity in 1089 aa overlap, and to e.g. Streptomyces sp streptothricin peptide synthase TR:O33743 (EMBL:Y10293) (481 aa), Fasta scores: E(): 5.6e-20, 31.2% identity in 382 aa overlap. Also similar to ML1051 and ML0243 from M. leprae. Similar to ML2665 a possible pseudogene similar to M. tuberculosis nrp. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q50177 No lipid metabolism PF00501,PF07993 Q50177 GO:0005488,GO:0008152,GO:0004043 Rv0101 Rv0101 AL450380.2 Mycobrowser_v4 CDS 2378501 2379907 . + 0 ML1991 PPE PPE-family protein ML1991, len: 468 aa. Member of the PPE-family. Similar to M. tuberculosis PPE-family protein Rv0096 SW:Y096_MYCTU (Q10892) (463 aa), Fasta scores: E(): 0, 58.6% identity in 466 aa overlap. Also similar to ML1828 and ML0539 from M. leprae. Contains Pfam match to entry PF00823 PPE, PPE family. Q9CBG5 No PE/PPE PF00823 Q9CBG5 Rv0096 Rv0096 AL450380.2 Mycobrowser_v4 CDS 2404476 2404895 . - 0 ML2012c ML2012c PROBABLE CONSERVED MEMBRANE PROTEIN ML2012c, len: 139 aa. Probable conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1903 or MTCY180.15C TR:O07729 (EMBL:Z97193) (134 aa) fasta scores: E(): 0, 80.6% identity in 129 aa and to Streptomyces coelicolor putative membrane proteins e.g. SCQ11.05C TR:Q9S1M9 (EMBL:AL096823) (125 aa) fasta scores: E(): 2.5e-15, 43.0% identity in 121 aa. Previously sequenced as TR:O33146 (EMBL:AJ000521). Contains hydrophobic, possible membrane-spanning regions. Q7AQ04 No cell wall and cell processes PF04020 Q7AQ04 Rv1903 Rv1903 AL450380.2 Mycobrowser_v4 CDS 1252907 1253297 . + 0 ML1089A ML1089A hypothetical protein(pseudogene) ML1089A, len:390. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2429330 2429809 . - 0 ML2038c bfrA INVOLVED IN IRON STORAGE (MAY PERFORM ANALOGOUS FUNCTIONS IN IRON DETOXIFICATION AND STORAGE AS THAT OF ANIMAL FERRITINS); FERRITIN IS AN INTRACELLULAR MOLECULE THAT STORES IRON IN A SOLUBLE, NONTOXIC, READILY AVAILABLE FORM. THE FUNCTIONAL MOLECULE, WHICH IS COMPOSED OF 24 CHAINS, IS ROUGHLY SPHERICAL AND CONTAINS A CENTRAL CAVITY IN WHICH THE POLYMERIC FERRIC IRON CORE IS DEPOSITED. PROBABLE BACTERIOFERRITIN BFRA ML2038c, len: 159 aa. Probable bfrA, bacterioferritin. Similar to Mycobacterium tuberculosis bacterioferritin SW:BFR_MYCTU (O08465) fasta scores: E(): 0, 90.1% in 152 aa, and to Brucella melitensis bacterioferritin SW:BFR_BRUME (P49944) fasta scores: E(): 8.5e-23, 44.6% in 139 aa. Contains Pfam match to entry PF01334 Bacteriofer, Bacterioferritin. P43315 No intermediary metabolism and respiration PF00210 P43315 GO:0005829,GO:0008199,GO:0006826,GO:0016020,GO:0016491,GO:0006879 Rv1876 Rv1876 AL450380.2 Mycobrowser_v4 CDS 2435566 2436810 . + 0 ML2046 lldD2 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 ML2046, len: 414 aa. Possible lldD2, L-lactate dehydrogenase (EC 1.1.2.3). Similar to Mycobacterium tuberculosis LLDD2 TR:P95143 (EMBL:AQ102036) fasta scores: E(): 0, 85.0% in 413 aa, and to Escherichia coli L-lactate dehydrogenase SW:LLDD_ECOLI (P33232) fasta scores: E(): 0, 37.3% in 383 aa. Contains Pfam match to entry PF01070 FMN_dh, FMN-dependent dehydrogenase. Contains PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. Q9CBF2 No intermediary metabolism and respiration PF01070 Q9CBF2 GO:0009055,GO:0008152,GO:0016491,GO:0010181 Rv1872c Rv1872c AL450380.2 Mycobrowser_v4 CDS 2442189 2442488 . - 0 ML2054c ML2054c probable integral membrane protein ML2054c, len: 99 aa. Probable integral membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein TR:P95154 (EMBL:Z83859) fasta scores: E(): 6.4e-18, 58.4% in 101 aa, and to Escherichia coli transglycosylase associated protein SW:TAG1_ECOLI (P76011) fasta scores: E(): 0.0054, 35.1% in 77 aa. Q9CBF0 No cell wall and cell processes PF04226 Q9CBF0 GO:0016021 Rv1861 Rv1861 AL450380.2 Mycobrowser_v4 CDS 2446563 2447237 . + 0 ML2059 ML2059 POSSIBLE OXIDOREDUCTASE ML2059, len: 224 aa. Possible oxidoreductase. Similar to Mycobacterium tuberculosis hypothetical 23.2 kda protein Rv1856c TR:P95158 (EMBL:Z83859) fasta scores: E(): 0, 80.5% in 220 aa, and to Streptomyces argillaceus ketoreductase TR:O86486 (EMBL:AJ007932) fasta scores: E(): 0.00044, 24.9% in 201 aa. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. Q7AQ00 No intermediary metabolism and respiration PF00106 Q7AQ00 GO:0008152,GO:0016491,GO:0005488 Rv1856c Rv1856c AL450380.2 Mycobrowser_v4 CDS 2476960 2478876 . + 0 ML2084 ML2084 PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER ML2084, len: 638 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter. Similar to Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein Rv1819c SW:YI19_MYCTU (Q50614) fasta scores: E(): 0, 74.9% in 634 aa, and in C-term to Escherichia coli hypothetical ABC transporter ATP-binding protein in pqql-hipa intergenic region SW:YDDA_ECOLI (P31826; P76133; P76876) fasta scores: E(): 0, 29.9% in 551 aa. Also similar to ML1089, ML1424, ML0848 and ML0590 from M. leprae. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Q7APZ0 No cell wall and cell processes PF00005,PF06472 Q7APZ0 GO:0042626,GO:0016021,GO:0006810,GO:0005524 Rv1819c Rv1819c AL450380.2 Mycobrowser_v4 CDS 2541992 2542423 . - 0 ML2140c ML2140c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY MARR-FAMILY) ML2140c, len: 143 aa. Possible transcriptional regulator, MarR family. Similar to Mycobacterium tuberculosis transcriptional regulator protein Rv0880 SW:Y880_MYCTU (Q10542) fasta scores: E(): 0, 90.2% in 143 aa, and to Streptomyces coelicolor putative marR-family protein TR:CAB93410 (EMBL:AL357524) fasta scores: E(): 1.6e-13, 39.6% in 134 aa. Also similar to ML2696 and ML0550 from M. leprae. Contains Pfam match to entry PF01047 MarR, MarR family. O33060 No regulatory proteins PF01047 O33060 GO:0006355,GO:0006350,GO:0003700,GO:0005622 Rv0880 Rv0880 AL450380.2 Mycobrowser_v4 CDS 2543014 2543823 . - 0 ML2142c ML2142c conserved hypothetical protein ML2142c, len: 269 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 27.5 kda protein Rv0877 SW:Y877_MYCTU (Q10539) fasta scores: E(): 0, 80.5% in 257 aa, and to Streptomyces coelicolor hypothetical 32.2 kda protein TR:CAB93404 (EMBL:AL357524) fasta scores: E(): 2.5e-19, 43.3% in 270 aa. Q7APY4 No conserved hypotheticals Q7APY4 Rv0877 Rv0877 AL450380.2 Mycobrowser_v4 CDS 2538742 2539872 . + 0 ML2136 serC CATALYZES THE REVERSIBLE INTERCONVERSION OF PHOSPHOSERINE AND 2-OXOGLUTARATE TO 3-PHOSPHONOOXYPYRUVATE AND GLUTAMATE. REQUIRE BOTH IN THE MAJOR PHOSPHORYLATED PATHWAY OF SERINE BIOSYNTHESIS AND IN PYRIDOXINE BIOSYNTHESIS [CATALYTIC ACTIVITY: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate]. POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC (PSAT) ML2136, len: 376 aa. Possible serC, phosphoserine aminotransferase. Similar to Mycobacterium tuberculosis putative phosphoserine aminotransferase Rv0884c SW:SERC_MYCTU (Q10534) fasta scores: E(): 0, 87.5% in 376 aa, and to Methanosarcina barkeri phosphoserine aminotransferase SW:SERC_METBA (P52878) fasta scores: E(): 4.5e-12, 24.7% in 369 aa. O33062 No intermediary metabolism and respiration PF00266 O33062 GO:0004648,GO:0005737,GO:0030170,GO:0008615,GO:0006564 2.6.1.52 Rv0884c Rv0884c AL450380.2 Mycobrowser_v4 CDS 2608120 2609055 . - 0 ML2193c mshD ACETYLTRANSFERASE MSHD ML2193c, len: 311 aa. Probable mshD, acetyltransferase. Similar to Mycobacterium tuberculosis acetyltransferase Rv0819 TR:O53831 (EMBL:AL022004) fasta scores: E(): 0, 75.2% in 314 aa. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. Q9CBC9 No intermediary metabolism and respiration PF00583 Q9CBC9 GO:0008152,GO:0008080 Rv0819 Rv0819 AL450380.2 Mycobrowser_v4 CDS 2613464 2614150 . + 0 ML2200 ML2200 conserved hypothetical protein ML2200, len: 228 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 23.9 kda protein Rv0813c TR:O53827 (EMBL:AL022004) fasta scores: E(): 0, 78.9% in 223 aa, and to Streptomyces coelicolor hypothetical 21.7 kda protein TR:CAB94083 (EMBL:AL358692) fasta scores: E(): 4.4e-11, 30.5% in 167 aa. Q9CBC6 No conserved hypotheticals PF08768 Q9CBC6 GO:0006810 Rv0813c Rv0813c AL450380.2 Mycobrowser_v4 CDS 2612903 2613205 . + 0 ML2199 sseC2 CONSERVED HYPOTHETICAL PROTEIN SSEC2 ML2199, len: 100 aa. Probable sseC2, conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 10.2 kda protein Rv0814c TR:O05794 (EMBL:Z95150) fasta scores: E(): 6.5e-33, 84.0% in 100 aa, and to Saccharopolyspora erythraea hypothetical 10.2 kda protein TR:Q54084 (EMBL:M29612) fasta scores: E(): 2.7e-16, 53.0% in 100 aa. Q9CBC7 No intermediary metabolism and respiration PF07210 Q9CBC7 Rv0814c Rv0814c AL450380.2 Mycobrowser_v4 CDS 2622304 2622699 . - 0 ML2207c ML2207c conserved hypothetical protein ML2207c, len: 131 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0807 or MTCY07H7A.02C TR:O06627 (EMBL:Z95618) (129 aa) fasta scores: E(): 0, 73.4% identity in 128 aa. Similar to Corynebacterium ammoniagenes ORF3 TR:Q9RHY2 (EMBL:AB003158) (132 aa) fasta scores: E(): 4.4e-22, 51.2% identity in 125 aa and to Streptomyces coelicolor hypothetical protein SCD25.20 TR:Q9RKK0 (EMBL:AL118514) (202 aa) fasta scores: E(): 6.6e-16, 52.5% identity in 101 aa. Previously sequenced as TR:O05761 (EMBL:Z95151). Q7APX7 No conserved hypotheticals Q7APX7 Rv0807 Rv0807 AL450380.2 Mycobrowser_v4 CDS 2625874 2626827 . - 0 ML2210c ML2210c conserved hypothetical protein ML2210c, len: 317 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0805 TR:O06629 (EMBL:Z95618) fasta scores: E(): 0, 82.5% id in 315 aa, and to Escherichia coli IcC protein ICC SW:ICC_ECOLI (P36650) fasta scores: E(): 1.2e-12, 30.7% identity in 215 aa. Q7APX5 No conserved hypotheticals, intermediary metabolism and respiration PF00149 Q7APX5 GO:0016787 Rv0805 Rv0805 AL450380.2 Mycobrowser_v4 CDS 2656453 2656857 . + 0 ML2237 ML2237 conserved hypothetical protein (HIT family) ML2237, len: 134 aa. Conserved hypothetical protein. Similar to Mycobacterium leprae hypothetical 14.7 kda protein MLCB5.04C TR:Q9R734 (EMBL:Z95151) fasta scores: E(): 0, 100.0% identity in 134 aa, and P71816|YHI1_MYCTU|Rv0759c Conserved hypothetical protein (133 aa), fasta scores: E(): 7.4e-49, (84.848% identity in 132 aa overlap); and to Borrelia burgdorferi hypothetical 15.9 kda hit-like protein PKCI OR BB0379 SW:YHIT_BORBU (P94252) fasta scores: E(): 5.2e-11, 42.3% identity in 111 aa. Contains Pfam match to entry PF01230 HIT, HIT family. Contains PS00892 HIT family signature. P49774 No conserved hypotheticals PF01230 P49774 GO:0003824 Rv0759c Rv0759c AL450380.2 Mycobrowser_v4 CDS 2682867 2683157 . - 0 ML2259c ML2259c POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN ML2259c, len: 96 aa. Possible conserved transmembrane protein. Similar to Mycobacterium tuberculosis transmembrane protein Rv0544c OR MTCY25D10.23C TR:O06410 (EMBL:Z95558) fasta scores: E(): 3.3e-22, 64.6% identity in 96 aa. Contains possible membrane spanning hydrophobic domains. Q9CBB7 No cell wall and cell processes Q9CBB7 Rv0544c Rv0544c AL450380.2 Mycobrowser_v4 CDS 2686566 2687468 . - 0 ML2263c menB PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE) ML2263c, len: 300 aa. Probable menB, naphthoate synthase (EC 4.1.3.36). Similar to Mycobacterium tuberculosis MenB or Rv0548c or MTCY25D10.27C TR:O06414 (EMBL:Z95558) fasta scores: E(): 0, 91.9% identity in 308 aa, and to Bacillus subtilis naphthoate synthase MENB SW:MENB_BACSU (P23966) fasta scores: E(): 0, 50.4% identity in 270 aa. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Q9CBB5 No intermediary metabolism and respiration PF00378 Q9CBB5 GO:0008935,GO:0009234 Rv0548c Rv0548c AL450380.2 Mycobrowser_v4 CDS 2691804 2692808 . + 0 ML2268 menC PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE) ML2268, len: 334 aa. Probable menC, muconate cycloisomerase (EC 5.5.1.1). Similar to Mycobacterium tuberculosis MenC or Rv0553 or MTCY25D10.32 TR:O06419 (EMBL:Z95558) (326 aa) fasta scores: E(): 0, 79.1% identity in 326 aa. Similar to isomerases e.g. Pseudomonas sp. chloromuconate cycloisomerase tcbD SW:TCBD_PSESQ (P27099) (370 aa) fasta scores: E(): 2.6e-10, 31.4% identity in 226 aa and to Rhodococcus opacus muconate cycloisomerase I catB SW:CATB_RHOOP (P95608) (373 aa) fasta scores: E(): 4.4e-09, 29.8% identity in 225 aa. Also similar to Amycolatopsis sp. N-acylamino acid racemase aaaR TR:Q44244 (EMBL:D30738) (368 aa) fasta scores: E(): 2.5e-06, 30.0% identity in 243 aa. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family. Q9CBB2 No intermediary metabolism and respiration PF01188 Q9CBB2 GO:0000287,GO:0009234,GO:0016836 4.2.1.113 Rv0553 Rv0553 AL450380.2 Mycobrowser_v4 CDS 2526724 2526795 . - 0 ML2125A ML2125A hypothetical protein(pseudogene) ML2125A, len:71. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.014 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2905097 2905357 . - 0 ML2429c ML2429c CONSERVED HYPOTHETICAL PROTEIN ML2429c, len: 86 aa. Conserved hypothetical protein. Similar to several including: Rv0500A conserved hypothetical protein from M. tuberculosis (78 aa), fasta scores: E(): 9.7e-27, (82.558% identity in 86 aa overlap) and Streptomyces coelicolor hypothetical protein TR:Q9WX06 (EMBL:AL079345) (70 aa) fasta scores: E(): 3.4e-14, 68.3% identity in 63 aa. Contains a probable helix-turn-helix motif at aa 33-54 (Score 1515, SD +4.35). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7APU8 No conserved hypotheticals Q7APU8 GO:0003677 Rv0500A Rv0500A AL450380.2 Mycobrowser_v4 CDS 2720563 2721267 . - 0 ML2295c ML2295c POSSIBLE PROTEASE ML2295c, len: 234 aa. Possible protease (EC 3.4.-.-). Similar to Mycobacterium tuberculosis possible protease Rv3668c or MTV025.016C TR:O69636 (EMBL:AL022121) (232 aa) fasta scores: E(): 0, 77.1% identity in 231 aa. Shows weak similarity to the C-terminal half of some proteases e.g. Thermomonospora fusca alkaline serine protease precursor TR:O86984 (EMBL:U65895) (368 aa) fasta scores: E(): 0.0018, 31.4% identity in 153 aa. Q9CB98 No intermediary metabolism and respiration Q9CB98 GO:0003824 Rv3668c Rv3668c AL450380.2 Mycobrowser_v4 CDS 2722984 2724189 . - 0 ML2298c ML2298c POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE ML2298c, len: 401 aa. Possible membrane-associated serine protease. Similar to Mycobacterium tuberculosis putative serine protease Rv3671c or MTV025.019C TR:O69639 (EMBL:AL022121) (397 aa) fasta scores: E(): 0, 80.9% identity in 398 aa. Similar to many putative serine proteases Streptomyces coelicolor putative serine protease SCH5.30C TR:Q9X932 (EMBL:AL035636) (385 aa) fasta scores: E(): 0, 39.0% identity in 385 aa. N-terminal half contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00089 trypsin, Trypsin. Q9CB95 No intermediary metabolism and respiration PF00089,PF02674 Q9CB95 GO:0006508,GO:0004252,GO:0009403,GO:0016020 Rv3671c Rv3671c AL450380.2 Mycobrowser_v4 CDS 2725032 2725679 . - 0 ML2300c ML2300c POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) ML2300c, len: 215 aa. Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein). Similar to Mycobacterium tuberculosis Rv3673c or MTV025.021C TR:O69641 (EMBL:AL022121) membrane protein, thioredoxin-like protein (227 aa) fasta scores: E(): 0, 71.2% identity in 215 aa. Shows weak similarity to Bacillus subtilis ResA protein resA SW:RESA_BACSU (P35160) (181 aa) fasta scores: E(): 5e-06, 31.6% identity in 114 aa and to thioredoxins. Contains hydrophobic, possible membrane-spanning region. Contains PS00194 Thioredoxin family active site. Q9CB93 No intermediary metabolism and respiration PF08534 Q9CB93 GO:0016491,GO:0045454 Rv3673c Rv3673c AL450380.2 Mycobrowser_v4 CDS 2727669 2728457 . - 0 ML2303c ML2303c POSSIBLE HYDROLASE ML2303c, len: 262 aa. Possible hydrolase. Similar to Mycobacterium tuberculosis putative hydrolase Rv3677c or MTV025.025C TR:O69645 (EMBL:AL022121) (264 aa) fasta scores: E(): 0, 83.9% identity in 255 aa. Shows similarity to putative bacterial hydrolases and also to eukaryotic proteins of unknown function. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Q9CB90 No intermediary metabolism and respiration PF00753 Q9CB90 GO:0016787 Rv3677c Rv3677c AL450380.2 Mycobrowser_v4 CDS 2729198 2730223 . + 0 ML2305 ML2305 PROBABLE ANION TRANSPORTER ATPASE ML2305, len: 341 aa. Probable anion transporter protein (EC 3.6.1.-). Similar to Mycobacterium tuberculosis Rv3679 SW:Y0H9_MYCTU (O69647) (340 aa) fasta scores: E(): 0, 84.2% identity in 341 aa, and to Streptomyces coelicolor putative ion-transporting ATPase TR:Q9XA36 (EMBL:AL079353) (325 aa) fasta scores: E(): 0, 52.4% identity in 330 aa. Q9CB88 No cell wall and cell processes PF02374 Q9CB88 GO:0006875,GO:0005524 Rv3679 Rv3679 AL450380.2 Mycobrowser_v4 CDS 2769449 2770201 . + 0 ML2337 ML2337 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2337, len: 250 aa. Probable conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv3723 TR:O69690 (EMBL:AL022121) (254 aa) fasta scores: E(): 0, 64.4% id in 253 aa. Contains possible membrane spanning hydrophobic domains. Q7APW1 No cell wall and cell processes Q7APW1 Rv3723 Rv3723 AL450380.2 Mycobrowser_v4 CDS 2734794 2735786 . + 0 ML2309 ML2309 conserved hypothetical protein ML2309, len: 330 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 34.4 kDa protein Rv3683 TR:O69651 (EMBL:AL022121) (319 aa) fasta scores: E(): 0, 85.8% identity in 298 aa, and to Streptomyces coelicolor conserved hypothetical protein TR:Q9X935 (EMBL:AL049731) (309 aa) fasta scores: E(): 2.2e-32, 51.5% identity in 295 aa. Q9CB84 No conserved hypotheticals PF00149 Q9CB84 GO:0016787 Rv3683 Rv3683 AL450380.2 Mycobrowser_v4 CDS 2907143 2907985 . - 0 ML2432c ML2432c conserved hypothetical protein ML2432c, len: 280 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0498 SW:Y498_MYCTU (Q11163) (280 aa) fasta scores: E(): 0, 89.3% identity in 280 aa, and to Streptomyces coelicolor hypothetical protein TR:Q9X8H0 (EMBL:AL049819) (285 aa) fasta scores: E(): 3.2e-30, 51.6% identity in 273 aa. P54581 No conserved hypotheticals PF01261 P54581 Rv0498 Rv0498 AL450380.2 Mycobrowser_v4 CDS 2752686 2753951 . - 0 ML2323c ask INVOLVED AT THE FIRST STEP IN THE COMMON BIOSYNTHETIC PATHWAY LEADING FROM ASP TO THE CELL WALL PRECURSOR MESO-DIAMINOPIMELATE, TO LYS, TO MET, TO ILE AND TO THR [CATALYTIC ACTIVITY: ATP + L-ASPARTATE = ADP + 4-PHOSPHO-L-ASPARTATE]. POSSIBLY ACTS IN TETRAMER CONFIGURATION, TETRAMER CONSISTING OF TWO ALPHA (CATALYTIC ACTIVITY) AND TWO BETA (FUNCTION NOT KNOWN) CHAINS. ASPARTOKINASE ASK (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA SUBUNIT (ASK-ALPHA); AND ASPARTOKINASE BETA SUBUNIT (ASK-BETA)] ML2323c, len: 421 aa. ask, aspartokinase (EC 2.7.2.4). Similar to Mycobacterium tuberculosis aspartokinase ask or Rv3709c or MTV025.057C SW:AK_MYCTU (P97048; O69676; P97181) (421 aa) fasta scores: E(): 0, 92.6% identity in 421 aa, and to Mycobacterium smegmatis aspartokinase asK SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 0, 85.3% identity in 421 aa. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00324 Aspartokinase signature. Q9CB77 No intermediary metabolism and respiration PF00696,PF01842 Q9CB77 GO:0008652,GO:0004072,GO:0016597 2.7.2.4 Rv3709c Rv3709c AL450380.2 Mycobrowser_v4 CDS 2760637 2761248 . - 0 ML2329c recR PROBABLE RECOMBINATION PROTEIN RECR ML2329c, 203 aa. Probable recR, recombination protein. Highly similar to many recombinational DNA repair RecR orthologues e.g. Mycobacterium tuberculosis Rv3715c SW:RECR_MYCTU (O69682) (203 aa) fasta scores: E(): 0, 91.1% identity in 202 aa and Bacillus subtilis recombination protein SW:RECR_BACSU (P24277) (198 aa) fasta scores: E(): 0, 51.5% identity in 198 aa. Contains Pfam match to entry PF02132 RecR, RecR protein. Contains Pfam match to entry PF01751 Toprim, Toprim domain. Contains PS01300 RecR protein signature. O69520 No information pathways PF01751,PF02132 O69520 GO:0006310,GO:0006281,GO:0008270,GO:0003677 Rv3715c Rv3715c AL450380.2 Mycobrowser_v4 CDS 2764455 2765717 . + 0 ML2334 ML2334 POSSIBLE FATTY ACID SYNTHASE ML2334, len: 420 aa. Possible fatty acid synthase. Similar to Mycobacterium tuberculosis fatty acid synthase Rv3720 TR:O69687 (EMBL:AL022121) (420 aa) fasta scores: E(): 0, 86.4% identity in 420 aa. The C-terminus is similar to several proteins involved in cyclopropane-fatty-acyl-phospholipid synthesis e.g. Escherichia coli SW:CFA_ECOLI (P30010) (381 aa) fasta scores: E(): 1.3e-27, 34.5% identity in 278 aa. Contains PS00107 Protein kinases ATP-binding region signature. Q9CB74 No lipid metabolism PF02353 Q9CB74 GO:0008610,GO:0008825 Rv3720 Rv3720 AL450380.2 Mycobrowser_v4 CDS 2792239 2793069 . - 0 ML2350c drrC PROBABLY INVOLVED IN ACTIVE TRANSPORT OF ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE MEMBRANE (EXPORT). DRRA|Rv2934|MTCY19H9.04, DRRB|Rv2937|MTCY19H9.05 AND DRRC MAY ACT JOINTLY TO CONFER DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT MECHANISM. PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE AND LOCALIZATION OF DIM INTO THE CELL WALL. PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC ML2350c, len: 276 aa. Probable drrC, daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport. Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% identity in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% identity in 252 aa. Also similar to the adjoining CDS ML2351. Contains possible membrane spanning hydrophobic domains. Q9CB71 No cell wall and cell processes PF01061 Q9CB71 GO:0042626,GO:0016020,GO:0006810,GO:0005524 Rv2938 Rv2938 AL450380.2 Mycobrowser_v4 CDS 2788307 2789317 . + 0 ML2347 ML2347 putative membrane protein ML2347, len: 336 aa. Putative membrane protein. Note the low G+C content of this CDS (46%). Weakly similar in part to Q9AC02 Hypothetical protein CC0067 from Caulobacter crescentus (253 aa), fasta scores: E(): 1.9e-11, (34.270% identity in 178 aa overlap). Contains a possible membrane spanning hydrophobic domain. Q7APW0 No cell wall and cell processes Q7APW0 GO:0008171 AL450380.2 Mycobrowser_v4 CDS 2789508 2790773 . + 0 ML2348 ML2348 Probable glycosyltransferase ML2348, len: 421 aa. Probable glycosyltransferase (EC 2.4.1.-). Similar to many proposed glycosyl transferases including: Mycobacterium tuberculosis hypothetical protein Rv1524 SW:YF24_MYCTU (Q50583) (414 aa) fasta scores: E(): 0, 62.6% identity in 420 aa, and to Mycobacterium avium rhamnosyltransferase RtfA TR:O69000 (EMBL:AF060183) (428 aa) fasta scores: E(): 0, 55.0% identity in 424 aa. Q49929 No intermediary metabolism and respiration PF03033 Q49929 GO:0030259,GO:0016758,GO:0005975 2.4.-.- Rv1524 Rv1524 AL450380.2 Mycobrowser_v4 CDS 2910203 2911036 . + 0 ML2435 ML2435 conserved hypothetical protein ML2435, len: 277 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0495c SW:Y495_MYCTU (Q11160) (296 aa) fasta scores: E(): 0, 82.7% identity in 271 aa, and to Streptomyces coelicolor hypothetical protein TR:Q9X8H2 (EMBL:AL049819) (271 aa) fasta scores: E(): 0, 48.4% identity in 250 aa. P54579 No conserved hypotheticals P54579 Rv0495c Rv0495c AL450380.2 Mycobrowser_v4 CDS 2821713 2823464 . - 0 ML2358c fadD26 FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) ML2358c, len: 583 aa. Probable fadd26, fatty-acid-CoA synthase (EC 6.2.1.-). Similar to several e.g. Q10976|FD26_MYCTU|Rv2930 Mycobacterium tuberculosis fatty-acid-CoA ligase (583 aa), fasta scores: E(): 2e-189, (76.844% identity in 583 aa overlap); and Q7TXM1 Fatty-acid-CoA ligase FADD26from M. bovis (583 aa), fasta scores: E(): 1.1e-189, (77.015% identity in 583 aa overlap). Also similar to ML0132, ML1234, ML0138 and ML0100 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Q9Z5K5 No lipid metabolism PF00501 Q9Z5K5 GO:0008152,GO:0003824 Rv2930 Rv2930 AL450380.2 Mycobrowser_v4 CDS 2858309 2858614 . + 0 ML2388 ML2388 PROBABLE CONSERVED MEMBRANE PROTEIN ML2388, len: 101 aa. Probable conserved membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0463 TR:O53748 (EMBL:AL021933) (97 aa) fasta scores: E(): 1.1e-18, 57.9% identity in 95 aa. Contains possible membrane spanning hydrophobic domains. Q7APV4 No cell wall and cell processes Q7APV4 Rv0463 Rv0463 AL450380.2 Mycobrowser_v4 CDS 2904753 2904854 . - 0 ML2428A ML2428A CONSERVED HYPOTHETICAL PROTEIN ML2428A, len: 33 aa. Conserved hypothetical protein, strongly basic. Highly similar to M. tuberculosis Rv0500B (33 aa), fasta scores: E(): 3.4e-14, 100.000% identity in 33 aa overlap. Also similar to Streptomyces coelicolor SCE68.25c, hypothetical protein, len : 32 aa unknown function, possible small, lysine-rich protein. FASTA scores: gp|AL079345|AL079345_25 Streptomyces coelicolor (32 aa) E(): 1.7e-07; 93.103% identity in 29 aa overlap P0A5D0 No conserved hypotheticals P0A5D0 Rv0500B Rv0500B AL450380.2 Mycobrowser_v4 CDS 2799411 2804879 . - 0 ML2354c ppsD PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD ML2354c, len: 1822 aa. Probable ppsD, type-I polyketide synthase. Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% identity in 2136 aa. Also similar to ML2353, ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00606 Beta-ketoacyl synthases active site. Q9CB70 No lipid metabolism PF00109,PF00550,PF00698,PF02801,PF08659 Q9CB70 GO:0009058,GO:0048037,GO:0031177,GO:0016740,GO:0000036 Rv2934 Rv2934 AL450380.2 Mycobrowser_v4 CDS 2902479 2903591 . - 0 ML2427c ML2427c conserved hypothetical protein ML2427c, len: 370 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0502 SW:Y502_MYCTU (Q11167) (358 aa) fasta scores: E(): 0, 85.2% identity in 359 aa. Contains a Pfam match to PF01553 Acyltransferase. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. P54878 No conserved hypotheticals PF01553 P54878 GO:0008152,GO:0008415 Rv0502 Rv0502 AL450380.2 Mycobrowser_v4 CDS 2794935 2799404 . - 0 ML2353c ppsE PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE ML2353c, len: 1489 aa. Probable ppsE, type-I polyketide synthase. Similar to many polyketide synthases e.g. Mycobacterium tuberculosis Rv2935 TR:P96204 (EMBL:Z83857) (1488 aa) fasta scores: E(): 0, 82.0% id in 1493 aa. Also similar to ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q49934 No lipid metabolism PF00109,PF00550,PF00668,PF00698,PF02801 Q49934 GO:0009058,GO:0048037,GO:0016740,GO:0000036 Rv2935 Rv2935 AL450380.2 Mycobrowser_v4 CDS 2863801 2864967 . - 0 ML2394c metB PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYLHOMOSERINE [THIOL]-LYASE) ML2394c, len: 388 aa. Probable metB, cystathionine [gamma]-synthase (EC4.2.99.9 ). Similar to Mycobacterium tuberculosis cystathionine gamma-synthase Rv1079 SW:METB_MYCTU (O53427) (388 aa) fasta scores: E(): 0, 87.3% identity in 387 aa, and to Corynebacterium glutamicum cystathionine gamma-synthase MetB TR:Q9RQ97 (EMBL:AF126953) (386 aa) fasta scores: E(): 0, 61.2% id in 376 aa. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. P46807 No intermediary metabolism and respiration PF01053 P46807 GO:0005737,GO:0009086,GO:0030170,GO:0003962 2.5.1.48 Rv1079 Rv1079 AL450380.2 Mycobrowser_v4 CDS 2871776 2872813 . + 0 ML2401 echA9 POSSIBLE ENOYL-CoA HYDRATASE ECHA9 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) ML2401, len: 345 aa. Possible echA9, enoyl-CoA hydratase (EC 4.2.1.17). Similar to several putative Prokaryotic and Eukaryotic enoyl-CoA hydratases including: Mycobacterium tuberculosis Rv1071c TR:O53419 (EMBL:AL021897) (345 aa) fasta scores: E(): 0, 77.7% id in 345 aa and Arabidopsis thaliana putative 3-hydroxyisobutyryl-coenzyme A hydrolase TR:O49330 (EMBL:AC002340) (410 aa) fasta scores: E(): 0, 35.1% id in 345 aa. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Q7APV2 No lipid metabolism PF00378 Q7APV2 GO:0008152,GO:0016853 Rv1071c Rv1071c AL450380.2 Mycobrowser_v4 CDS 2407307 2408605 . - 0 ML2015c cinA PROBABLE CINA-LIKE PROTEIN CINA ML2015c, len: 1299 bp. Probable cina, competence damage protein homolog. Similar to M. tuberculosis competence damage protein homolog cinA Rv1901 TR:O07731 (EMBL:Z97193) (430 aa), Fasta scores: E(): 0, 77.0% identity in 431 aa overlap, and to e.g. Streptococcus pneumoniae putative competence-damage protein SW:CINA_STRPN (P54184) (418 aa), Fasta scores: E(): 1.4e-22, 31.0% identity in 439 aa overlap. Q9X7D6 No virulence, detoxification, adaptation PF00994,PF02464 Q9X7D6 GO:0006777 Rv1901 Rv1901 AL450380.2 Mycobrowser_v4 CDS 2877405 2878289 . + 0 ML2406 menA INVOLVED IN MENAQUINONE BIOSYNTHESIS. CONVERSION OF 1,4-DIHYDROXY-2-NAPHTHOATE (DHNA) TO DIMETHYLMENAQUINONE (DMK). ATTACHES OCTAPRENYLPYROPHOSPHATE, A MEMBRANE-BOUND 40-CARBON SIDE CHAIN TO DHNA. THE CONVERSION OF DHNA TO DMK PROCEEDS IN THREE STAGES: THE REMOVAL OF THE CARBOXYL GROUP OF DHNA AS CO2, THE ATTACHMENT OF THE ISOPRENOID SIDE CHAIN, AND A QUINOL-TO-QUINONE OXIDATION, WHICH IS THOUGHT TO BE SPONTANEOUS. 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE MENA (DHNA-OCTAPRENYLTRANSFERASE) ML2406, len: 294 aa. Probable menA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase (EC 2.5.1.-), integral membrane protein. Similar to Mycobacterium tuberculosis probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase Rv0534c SW:MENA_MYCTU (O06400) (292 aa) fasta scores: E(): 0, 80.6% identity in 288 aa, and to Escherichia coli 1,4-dihydroxy-2-naphthoate octaprenyltransferase menA SW:MENA_ECOLI (P32166) (308 aa) fasta scores: E(): 1.6e-24, 34.4% identity in 276 aa. Contains possible membrane spanning hydrophobic domains. O07134 No intermediary metabolism and respiration PF01040 O07134 GO:0016021,GO:0009234,GO:0005886,GO:0004659 2.5.1.- Rv0534c Rv0534c AL450380.2 Mycobrowser_v4 CDS 2097381 2097452 . - 0 ML1736A ML1736A hypothetical protein(pseudogene) ML1736A, len:71. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2064082 2065038 . - 0 ML1711c fixB PROBABLE ELECTRON TRANSFER FLAVOPROTEIN (ALPHA-SUBUNIT) FIXB (ALPHA-ETF) (ELECTRON TRANSFER FLAVOPROTEIN LARGE SUBUNIT) (ETFLS) ML1711c, len: 318 aa. Probable fixB (alternate gene name: etfA), electron transfer flavoprotein (alpha subunit) for various dehydrogenases. Highly similar to many electron transfer flavoprotein alpha-subunits, including: Paracoccus denitrificans SW:ETFA_PARDE (P38974) (307 aa), Fasta scores: E(): 0, 43.3% identity in 307 aa overlap and Mycobacterium tuberculosis Rv3028c SW:ETFA_MYCTU (O53275) (318 aa), Fasta scores: E(): 0, 89.3% identity in 318 aa overlap. Contains Pfam match to entry PF00766 ETF_alpha, Electron transfer flavoprotein alpha subunit. Contains PS00696 Electron transfer flavoprotein alpha-subunit signature. Note previously known as eftA. O33096 No intermediary metabolism and respiration PF00766,PF01012 O33096 GO:0009055,GO:0022900,GO:0006810,GO:0050660 Rv3028c Rv3028c AL450380.2 Mycobrowser_v4 CDS 2442648 2443511 . - 0 ML2055c apa ALANINE AND PROLINE RICH SECRETED PROTEIN APA (FIBRONECTIN ATTACHMENT PROTEIN) (Immunogenic protein MPT32) (Antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) ML2055c, len: 287 aa. Probable apa (alternate gene names: mpt32, modD), Ala-, Pro-rich 45/47 kDa secreted protein. Previously sequenced Mycobacterium leprae TR:Q9R5V6 fasta scores: E(): 0, 100.0% in 287 aa. The product of this CDS has also been shown to be highly immunogenic, Mycobacterium leprae molybdate uptake protein SW:MODD_MYCLE (P46842) fasta scores: E(): 0, 99.3% in 287 aa, and highly similar to several proteins involved in the uptake of molybdenum in other mycobacteria e.g. Mycobacterium tuberculosis molybdate uptake secreted protein precursor Rv1860 SW:MODD_MYCTU (Q50906; O08062) fasta scores: E(): 0, 66.8% in 298 aa. Contains a possible N-terminal signal sequence. Previously known as modD. P46842 No cell wall and cell processes PF07174 P46842 GO:0005576,GO:0050840 Rv1860 Rv1860 AL450380.2 Mycobrowser_v4 CDS 2340161 2341441 . - 0 ML1953c glyA Probable Serine hydroxymethyltransferase 1 GlyA ML1953c, len: 426 aa. Probable glyA, Serine hydroxymethyltransferase 1 (EC 2.1.2.1). Similar to M. tuberculosis serine hydroxymethyltransferase glyA1 Rv1093 SW:GLA1_MYCTU (O53441) (426 aa), Fasta scores: E(): 0, 89.9% identity in 426 aa overlap, and to many others e.g. Escherichia coli serine hydroxymethyltransferase SW:GLYA_ECOLI (P00477) (417 aa), Fasta scores: E(): 0, 53.5% identity in 415 aa overlap. Contains Pfam match to entry PF00464 SHMT, Serine hydroxymethyltransferase. Q9X794 No intermediary metabolism and respiration PF00464 Q9X794 GO:0005737,GO:0004372,GO:0006544,GO:0006730,GO:0030170,GO:0006563 2.1.2.1 Rv1093 Rv1093 AL450380.2 Mycobrowser_v4 CDS 2916624 2917367 . - 0 ML2441c gpm1 PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) ML2441c, len: 247 aa. Probable gpm1, phosphoglycerate mutase. Highly similar to many phosphoglycerate mutases including: Streptomyces coelicolor SW:PMGY_STRCO (P33158) (252 aa) fasta scores: E(): 0, 66.3% identity in 240 aa, and Mycobacterium tuberculosis phosphoglycerate mutase Rv0489 SW:PMGY_MYCTU (Q11140) (249 aa) fasta scores: E(): 0, 89.0% identity in 236 aa. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. P53531 No intermediary metabolism and respiration PF00300 P53531 GO:0006096,GO:0046538 5.4.2.1 Rv0489 Rv0489 AL450380.2 Mycobrowser_v4 CDS 2491072 2492181 . - 0 ML2095c pstS3 PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS3 (PBP-3) (PSTS3) (PHOS1) ML2095c, len: 369 aa. Probable pstS3 (previously known as phoS2), phosphate-binding lipoprotein component of inorganic phosphate transport system. Similar to Mycobacterium tuberculosis phosphate-binding protein 3 precursor TR:O86343 Rv0928 (EMBL:Z95209) fasta scores: E(): 0, 77.3% in 370 aa, and to Escherichia coli phosphate-binding periplasmic protein precursor SW:PSTS_ECOLI (P06128; P76744) fasta scores: E(): 4.4e-22, 31.2% in 333 aa. Also similar to ML2192c from M. leprae. Contains Pfam match to entry PF01449 PstS, Phosphate-binding protein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Previously known as phoS2. Q9CBE5 No cell wall and cell processes PF01547 Q9CBE5 GO:0006817,GO:0005886,GO:0005315 Rv0928 Rv0928 AL450380.2 Mycobrowser_v4 CDS 2969708 2970874 . - 0 ML2494c dnaJ1 PROBABLE CHAPERONE PROTEIN DNAJ1 ML2494c, len: 388 aa. Probable dnaJ1, chaperone protein. Similar to Mycobacterium tuberculosis DnaJ protein Rv0352 SW:DNAJ_MYCTU (P07881; O08380) fasta scores: E(): 0, 91.8% identity in 391 aa. Also similar to ML0625 from M. leprae. Contains Pfam match to entry PF01556 DnaJ_C, DnaJ C terminal region. Contains Pfam match to entry PF00684 DnaJ_CXXCXGXG, DnaJ central domain (4 repeats). Contains Pfam match to entry PF00226 DnaJ, DnaJ domain. Contains PS00636 Nt-dnaJ domain signature. Contains PS00637 CXXCXGXG dnaJ domain signature. Note previously known as dnaJ. Q02605 No virulence, detoxification, adaptation PF00226,PF00684,PF01556 Q02605 GO:0006260,GO:0005737,GO:0031072,GO:0006457,GO:0009408,GO:0051082,GO:0008270,GO:0005524 Rv0352 Rv0352 AL450380.2 Mycobrowser_v4 CDS 2105689 2105847 . + 0 ML1744A ML1744A hypothetical protein(pseudogene) ML1744A, len:158. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2642867 2645041 . - 0 ML2226c ptrB PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) ML2226c, len: 724 aa. Probable ptrB, protease II (EC 3.4.21.83). Similar at the C-terminal region to Mycobacterium tuberculosis hypothetical ptrBb Rv0782 OR MTCY369.26 TR:P71835 (EMBL:Z80226) fasta scores: E(): 0, 77.8% identity in 519 aa, and at the N-terminal region to Rv0781|ptrBa (236 aa), fasta scores: E(): 4.1e-62, (69.912% identity in 226 aa overlap). Also similar to Escherichia coli protease ii PTRB OR TLP SW:PTRB_ECOLI (P24555; P78068) fasta scores: E(): 0, 38.2% identity in 702 aa. Contains Pfam match to entry PF00326 Peptidase_S9, Prolyl oligopeptidase family. O05748 No intermediary metabolism and respiration PF00326,PF02897 O05748 GO:0004252,GO:0006508 Rv0782 Rv0782 AL450380.2 Mycobrowser_v4 CDS 1920920 1922326 . - 0 ML1596c amiC PROBABLE AMIDASE AMIC (AMINOHYDROLASE) ML1596c, len: 468 aa. Probable amiC, amidase (EC 3.5.1.4). Highly similar to several proposed amidases including: Pseudomonas putida SW:AMID_PSEPU (O69768) (466 aa), Fasta scores: E(): 2.9e-19, 29.0% identity in 469 aa overlap and Mycobacterium tuberculosis Rv2888c SW:AMI3_MYCTU (Q10811) (473 aa), Fasta scores: E(): 0, 76.7% identity in 468 aa overlap. Contains Pfam match to entry PF01425 Amidase, Amidase. Contains PS00571 Amidases signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O33040 No intermediary metabolism and respiration PF01425 O33040 GO:0016884,GO:0004040 3.5.1.4 Rv2888c Rv2888c AL450380.2 Mycobrowser_v4 CDS 1913904 1914842 . - 0 ML1589c cdsA PROBABLE INTEGRAL MEMBRANE PHOSPHATIDATE CYTIDYLYLTRANSFERASE CDSA (CDP-DIGLYCERIDE SYNTHETASE) (CDP-DIGLYCERIDE PYROPHOSPHORYLASE) (CDP-DIACYLGLYCEROL SYNTHASE) (CDS) (CTP:PHOSPHATIDATE CYTIDYLYLTRANSFERASE) (CDP-DAG SYNTHASE) (CDP-DG SYNTHETASE) ML1589c, len: 312 aa. Probable cdsA, integral membrane phosphatidate cytidylyltransferase (EC 2.7.7.41). Highly similar to several e.g. Mycobacterium tuberculosis Rv2881c SW:CDSA_MYCTU (Q10807) (306 aa), Fasta scores: E(): 0, 70.3% identity in 313 aa overlap and Q8FP76 Putative phosphatidate cytidylyltrans from Corynebacterium efficiens (297 aa), fasta score: E(): 6.2e-54, (48.986% identity in 296 aa overlap). Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferase. Contains PS01315 Phosphatidate cytidylyltransferase signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBU1 No lipid metabolism PF01148 Q9CBU1 GO:0004605,GO:0008654,GO:0005886,GO:0016021 2.7.7.41 Rv2881c Rv2881c AL450380.2 Mycobrowser_v4 CDS 3260985 3261764 . - 0 ML2705c ML2705c conserved hypothetical protein ML2705c, len: 259 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 26.6 kda protein Rv3916c TR:O53594 (EMBL:AL021426) fasta scores: E(): 0, 76.4% in 250 aa, and to Streptomyces coelicolor hypothetical 22.6 kda protein TR:Q9R3S2 (EMBL:AF187159) fasta scores: E(): 1e-08, 39.7% in 237 aa. Q7APR6 No conserved hypotheticals Q7APR6 Rv3916c Rv3916c AL450380.2 Mycobrowser_v4 CDS 2624331 2625959 . + 0 ML2209 cpsY POSSIBLE UDP-GLUCOSE-4-EPIMERASE CPSY (GALACTOWALDENASE) (UDP-GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE-4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE-4-EPIMERASE) ML2209, len: 542 aa. Probable cpsY, UDP-glucose-4-epimerase (EC 5.1.3.2). Similar to Mycobacterium tuberculosis hypothetical 60.3 kda protein Rv0806c TR:O06628 (EMBL:Z95618) fasta scores: E(): 0, 82.3% id in 530 aa, and to Neisseria meningitidis capsule gene complex upd-glucose-4-epimerase TR:Q51151 (EMBL:L09188) fasta scores: E(): 9.2e-26, 30.0% identity in 317 aa. Q50025 No cell wall and cell processes Q50025 GO:0016740,GO:0000271 2.7.-.- Rv0806c Rv0806c AL450380.2 Mycobrowser_v4 CDS 2765714 2767549 . - 0 ML2335c dnaZX DNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' EXONUCLEASE ACTIVITY [CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + DNA(N)]. DNA POLYMERASE III (SUBUNIT GAMMA/TAU) DNAZ/X ML2335c, len: 611 aa. dnaZX, DNA polymerase III, subunit gamma/tau (EC 2.7.7.7). Highly similar to many DNA polymerase III subunit gamma/tau including: Mycobacterium tuberculosis DnaZX Rv3721c SW:DP3X_MYCTU (O69688) (578 aa) fasta scores: E(): 0, 78.7% identity in 602 aa and to Escherichia coli SW:DP3X_ECOLI (P06710; Q47721) (643 aa) fasta scores: E(): 0, 34.2% identity in 521 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O69514 No information pathways PF00004 O69514 GO:0003677,GO:0009360,GO:0006260,GO:0003887,GO:0017111,GO:0005524 Rv3721c Rv3721c AL450380.2 Mycobrowser_v4 CDS 3101362 3102339 . + 0 ML2596 ML2596 PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE PROTEIN ML2596, len: 325 aa. Probable conserved Mce associated transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0176 TR:O07420 (EMBL:Z97050) fasta scores: E(): 0, 54.9% identity in 319 aa. Contains multiple possible membrane spanning hydrophobic domains. Q9CD07 No cell wall and cell processes PF06271 Q9CD07 Rv0176 Rv0176 AL450380.2 Mycobrowser_v4 CDS 2021826 2022980 . - 0 ML1678c ddlA PROBABLE D-ALANINE--D-ALANINE LIGASE DDLA (D-ALANYLALANINE SYNTHETASE) (D-ALA-D-ALA LIGASE) ML1678c, len: 384 aa. Probable ddlA, D-alanine-D-alanine ligase A (EC 6.3.2.4). Highly similar to D-alanine--D-alanine ligase A from many including: Salmonella typhimurium SW:DDLA_SALTY (P15051) (363 aa), Fasta scores: E(): 0, 43.5% identity in 368 aa overlap and Mycobacterium tuberculosis Rv2981c SW:DDL_MYCTU (P95114) (373 aa), Fasta scores: E(): 0, 81.7% identity in 367 aa overlap. Contains Pfam match to entry PF01820 Dala_Dala_ligas, D-ala D-ala ligase. Contains PS00844 D-alanine--D-alanine ligase signature 2. Contains PS00843 D-alanine--D-alanine ligase signature 1. Q9CBS0 No cell wall and cell processes PF01820,PF07478 Q9CBS0 GO:0008716,GO:0005618,GO:0007047,GO:0005737,GO:0000287,GO:0030145,GO:0009252,GO:0008360,GO:0005524 6.3.2.4 Rv2981c Rv2981c AL450380.2 Mycobrowser_v4 CDS 2339277 2340104 . - 0 ML1952c desA2 THOUGHT TO CATALYZE THE PRINCIPAL CONVERSION OF SATURATED FATTY ACIDS TO UNSATURATED FATTY ACIDS. THOUGHT TO CONVERT STEAROYL-ACP TO OLEOYL-ACP BY INTRODUCTION OF A CIS DOUBLE BOND BETWEEN CARBONS DELTA-9 AND DELTA-10 OF THE ACYL CHAIN [CATALYTIC ACTIVITY: Stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + A + 2 H2O]. POSSIBLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA2 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) ML1952c, len: 275 aa. Possible desA2, acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.99.6). Similar to M. tuberculosis acyl-[ACP] desaturase desA2 TR:O53442 (EMBL:AL021897) (275 aa), Fasta scores: E(): 0, 78.1% identity in 274 aa overlap, and to others e.g. Gossypium hirsutum (Upland cotton) acyl-[acyl-carrier protein] desaturase precursor SW:STAD_GOSHI (X95988) (397 aa), Fasta scores: E(): 5.6e-05, 23.9% identity in 293 aa overlap. Also similar to ML2185 from M. leprae. Q9X793 No lipid metabolism PF03405 Q9X793 GO:0006631,GO:0046914,GO:0045300 Rv1094 Rv1094 AL450380.2 Mycobrowser_v4 CDS 2023092 2024147 . - 0 ML1679c gpdA2 PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA (NAD(P)H- DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) ML1679c, len: 351 aa. Probable gpdA, glycerol-3-phosphate dehydrogenase (EC 1.1.1.94). Highly similar to many glycerol-3-phosphate dehydrogenases including: Escherichia coli SW:GPDA_ECOLI (P37606) (339 aa), Fasta scores: E(): 0, 39.9% identity in 341 aa overlap and Mycobacterium tuberculosis Rv2982c TR:P95113 (EMBL:Z83018) (334 aa), Fasta scores: E(): 0, 77.9% identity in 349 aa overlap. Contains Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. Q9CBR9 No lipid metabolism PF01210,PF07479 Q9CBR9 GO:0005975,GO:0046167,GO:0046168,GO:0004367,GO:0047952,GO:0009331,GO:0055114,GO:0008654,GO:0051287 1.1.1.94 Rv2982c Rv2982c AL450380.2 Mycobrowser_v4 CDS 2793066 2793932 . - 0 ML2351c drrB PROBABLY INVOLVED IN ACTIVE TRANSPORT OF ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE MEMBRANE (EXPORT). DRRA|Rv2934|MTCY19H9.04, DRRB AND DRRC|Rv2938|MTCY19H9.06 MAY ACT JOINTLY TO CONFER DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT MECHANISM. PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE AND LOCALIZATION OF DIM INTO THE CELL WALL. PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRB ML2351c, len: 288 aa. Probable drrB, daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport. Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2937 TR:P96206 (EMBL:Z83857) (289 aa) fasta scores: E(): 0, 64.0% identity in 289 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 4.2e-06, 22.7% identity in 229 aa. Also similar to the adjoining CDS ML2350. Contains possible membrane spanning hydrophobic domains. Q49935 No cell wall and cell processes PF01061 Q49935 GO:0016020 Rv2937 Rv2937 AL450380.2 Mycobrowser_v4 CDS 2268194 2268952 . - 0 ML1889c end INVOLVED IN BASE EXCISION REPAIR. ENDONUCLEASE IV PLAYS A ROLE IN DNA REPAIR. IT CLEAVES PHOSPHODIESTER BONDS AT APURINIC OR APYRIMIDINIC SITES (AP SITES) TO PRODUCE NEW 5' ENDS THAT ARE BASE-FREE DEOXYRIBOSE 5-PHOSPHATE RESIDUES [CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products]. PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) ML1889c, len: 252 aa. Probable end, endonuclease IV (EC 3.1.21.2). Similar to Mycobacterium tuberculosis probable endonuclease IV nfo or end or Rv0670 or MTCI376.04C SW:END4_MYCTU (O86366) (252 aa) fasta scores: E(): 0, 85.6% identity in 250 aa. Similar to many putative endonucleases. Previously sequenced as SW:END4_MYCLE (P30770). Contains Pfam match to entry PF01261 AP_endonulease2, AP endonuclease family 2. Contains PS00730 AP endonucleases family 2 signature 2. Contains PS00731 AP endonucleases family 2 signature 3. Contains PS00729 AP endonucleases family 2 signature 1. P30770 No information pathways PF01261 P30770 GO:0006281,GO:0008833,GO:0005622,GO:0008270,GO:0003677 3.1.21.2 Rv0670 Rv0670 AL450380.2 Mycobrowser_v4 CDS 2122905 2123066 . + 0 ML1752A ML1752A hypothetical protein(pseudogene) ML1752A, len:161. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2187641 2188402 . - 0 ML1807c fabG1 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEIN) ML1807c, len: 253 aa. Probable fabG1, 3-oxoacyl-[ACP] reductase (EC 1.1.1.100). Similar to M. tuberculosis fabG Rv1483 SW:FABG_MYCTU (Q48930) (247 aa), Fasta scores: E(): 0, 68.6% identity in 245 aa overlap, and to many others e.g. Escherichia coli fabG 3-oxoacyl-[acyl-carrier protein] reductase SW:FABG_ECOLI (P25716) (244 aa), Fasta scores: E(): 0, 47.3% identity in 241 aa overlap. Also similar to ML1806, ML2565, ML1740, ML1094, ML0862, ML0135, ML0135, ML0429, ML2357, ML0108 and ML2059 from M. leprae. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Q9CBM0 No lipid metabolism PF00106 Q9CBM0 GO:0051287,GO:0006633,GO:0004316 Rv1483 Rv1483 AL450380.2 Mycobrowser_v4 CDS 2571317 2572528 . - 0 ML2162c fadA POSSIBLE ACYL-CoA THIOLASE FADA ML2162c, len: 403 aa. Possible fadA, acyl-CoA thiolase (EC 2.3.1.-). Similar to Mycobacterium tuberculosis putative acyl- CoA thiolase Rv0859 TR:O53871 (EMBL:AL022004) fasta scores: E(): 0, 94.5% in 403 aa, and to Escherichia coli acetyl-coa acetyltransferase TR:O53017 (EMBL:X97452) fasta scores: E(): 0, 44.1% in 422 aa, and to Acinetobacter calcoaceticus beta-ketoadipyl coa thiolase SW:PCAF_ACICA (Q43974) fasta scores: E(): 0, 40.9% in 425 aa. Also similar to ML1158 and ML2564 from M. leprae. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00098 Thiolases acyl-enzyme intermediate signature. Contains PS00099 Thiolases active site. Contains PS00737 Thiolases signature 2. Q9CBD7 No lipid metabolism PF00108,PF02803 Q9CBD7 GO:0008152,GO:0003824 Rv1323,Rv0859 Rv1323,Rv0859 AL450380.2 Mycobrowser_v4 CDS 2452186 2453637 . + 0 ML2065 gnd1 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 ML2065, len: 483 aa. Probable gnd1, 6-phosphogluconate dehydrogenase (EC 1.1.1.44). Similar to Mycobacterium tuberculosis cosmid gnd TR:P95165 (EMBL:AL008609) fasta scores: E(): 0, 86.8% in 485 aa and to Bacillus subtilis 6-phosphogluconate dehydrogenase, decarboxylating II SW:6PG2_BACSU (P80859; P54546) fasta scores: E(): 0, 55.7% in 465 aa. Contains Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogenases. Q9CBE9 No intermediary metabolism and respiration PF00393,PF03446 Q9CBE9 GO:0006098,GO:0004616,GO:0050661 1.1.1.44 Rv1844c Rv1844c AL450380.2 Mycobrowser_v4 CDS 2535820 2537487 . - 0 ML2134c fprB PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) ML2134c, len: 555 aa. Probable fprB, ferredoxin, ferredoxin-NADP reductase (EC 1.18.1.2). Similar to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase Rv0886 SW:FPRB_MYCTU (Q10547) fasta scores: E(): 0, 76.6% in 560 aa, and to Homo sapiens NADPH:adrenodoxin oxidoreductase precursor SW:ADRO_HUMAN (P22570; Q13716) fasta scores: E(): 2.9e-30, 37.4% in 484 aa. Contains 2 Pfam matches to entry PF00037 fer4, 4Fe-4S binding domain. Contains PS00198 4Fe-4S ferredoxins. O33064 No intermediary metabolism and respiration PF00037,PF07992 O33064 GO:0009055,GO:0022900,GO:0004324,GO:0005506,GO:0006810,GO:0051539 1.18.1.2 Rv0886 Rv0886 AL450380.2 Mycobrowser_v4 CDS 2333631 2335055 . + 0 ML1947 fum PROBABLE FUMARASE FUM (Fumarate hydratase) ML1947, len: 474 aa. Probable fum, fumarase (EC 4.2.1.2). Similar to M. tuberculosis fumarase Rv1098c fum TR:O53446 (EMBL:AL021897) (474 aa), Fasta scores: E(): 0, 89.5% identity in 467 aa overlap, and to many others e.g Homo sapiens fumarate hydratase, mitochondrial precursor SW:FUMH_HUMAN (P07954) (510 aa), Fasta scores: E(): 0, 52.1% identity in 461 aa overlap. Also similar to ML1413 and ML2230 from M. leprae. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature. Q9X789 No intermediary metabolism and respiration PF00206,PF10415 Q9X789 GO:0003824 Rv1098c Rv1098c AL450380.2 Mycobrowser_v4 CDS 2219409 2220209 . - 0 ML1831c mapA PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) ML1831c, len: 266 aa. Probable mapA, methionine aminopeptidase (EC 3.4.11.18). Similar to M. tuberculosis methionine aminopeptidase mapA Rv0734 TR:O53797 (EMBL:AL021958) (266 aa), Fasta scores: E(): 0, 84.0% identity in 262 aa overlap, and to many others e.g. Bacillus subtilis methionine aminopeptidase SW:AMPM_BACSU (P19994) (248 aa), Fasta scores: E(): 0, 43.3% identity in 245 aa overlap. Also similar to ML1576 and ML0521 from M. leprae. Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24. O33008 No intermediary metabolism and respiration PF00557 O33008 GO:0008235,GO:0006508,GO:0004177 3.4.11.18 Rv0734 Rv0734 AL450380.2 Mycobrowser_v4 CDS 2166241 2166545 . - 0 ML1790A ML1790A hypothetical protein(pseudogene) ML1790A, len:304. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1959892 1962906 . - 0 ML1630c glnE REGULATORY PROTEIN INVOLVED IN THE REGULATION OF GLUTAMINE SYNTHETASE ACTIVITY. ADENYLYLATION AND DEADENYLYLATION OF GLUTAMINE SYNTHETASE. POSSIBLY REGULATES GLNB|Rv2919c [CATALYTIC ACTIVITY: ATP + [L-GLUTAMATE:AMMONIA LIGASE (ADP-FORMING)] = PYROPHOSPHATE + ADENYLYL-[L-GLUTAMATE:AMMONIA LIGASE (ADP-FORMING)]]. GLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE (Glutamine-synthetase adenylyltransferase) ML1630c, len: 1004 aa. Probable glnE, glutamate-ammonia-ligase adenyltransferase (EC 2.7.7.42). Similar to several glutamate-ammonia-ligase adenylyltransferases including: Escherichia coli SW:GLNE_ECOLI (P30870) (946 aa), Fasta scores: E(): 2.4e-21, 28.2% identity in 929 aa overlap and Mycobacterium tuberculosis Rv2221c SW:GLNE_MYCTU (Q10379) (994 aa), Fasta scores: E(): 0, 82.8% identity in 998 aa overlap. Q9CBT4 No intermediary metabolism and respiration PF03710,PF08335 Q9CBT4 GO:0005524,GO:0008882 2.7.7.42 Rv2221c Rv2221c AL450380.2 Mycobrowser_v4 CDS 2033591 2035099 . - 0 ML1688c gltS PROBABLE GLUTAMYL-TRNA SYNTHETASE GLTS (GLUTAMATE--TRNA LIGASE) (GLUTAMYL-TRNA SYNTHASE) (GLURS) ML1688c, len: 502 aa. Probable gltS, glutamyl-tRNA synthase (EC 6.1.1.17). Highly similar to many glutamyl-tRNA synthetases including: Bacillus subtilis SW:SYE_BACSU (P22250) (483 aa), Fasta scores: E(): 0, 37.4% identity in 486 aa overlap and Mycobacterium tuberculosis Rv2992c SW:SYE_MYCTU (O53241) (490 aa), Fasta scores: E(): 0, 81.4% identity in 488 aa overlap. Contains Pfam match to entry PF00749 tRNA-synt_1c, tRNA synthetases class I (E and Q). O33120 No information pathways O33120 GO:0005737,GO:0004818,GO:0006424,GO:0005524 6.1.1.17 Rv2992c Rv2992c AL450380.2 Mycobrowser_v4 CDS 1283592 1284053 . - 0 ML1109A ML1109A hypothetical protein(pseudogene) ML1109A, len:461. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-34 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2701274 2702137 . + 0 ML2278 htpX PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX ML2278, len: 287 aa. Probable htpX, protease heat shock protein X (EC 3.4.24.-) (transmembrane protein). Similar to Mycobacterium tuberculosis probable protease htpX or Rv0563 or MTV039.01 or MTCY25D10.42 SW:HTPX_MYCTU (O06429) (286 aa) fasta scores: E(): 0, 88.5% identity in 286 aa. Similar to many homologues of Escherichia coli probable protease and heat-shock protein HtpX SW:HTPX_ECOLI (P23894) (293 aa) blastp scores: 78.1 bits, 30% identity in 253 aa. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01435 Peptidase_M48, Peptidase family M48. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Q9CBA4 No virulence, detoxification, adaptation PF01435 Q9CBA4 GO:0004222,GO:0005886,GO:0006508,GO:0008270,GO:0016021 3.4.24.- Rv0563 Rv0563 AL450380.2 Mycobrowser_v4 CDS 2475220 2476866 . - 0 ML2083c ilvG Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) ML2083c, len: 548 aa. Probable ilvG, Acetolactate synthase (EC 4.1.3.18). Similar to Mycobacterium tuberculosis probable acetolactate synthase SW:ILVG_MYCTU (Q50613) fasta scores: E(): 0, 86.1% in 548 aa, and to Bacillus subtilis acetolactate synthase large subunit SW:ILVB_BACSU (P37251; P94564) fasta scores: E(): 1.2e-32, 28.5% in 543 aa. Also similar to ML1696, ML2167 and ML0354 from M. leprae. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature. O32923 No intermediary metabolism and respiration PF00205,PF02775,PF02776 O32923 GO:0030976,GO:0016740,GO:0000287 Rv1820 Rv1820 AL450380.2 Mycobrowser_v4 CDS 2030179 2031636 . - 0 ML1685c leuC PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) ML1685c, len: 485 aa. Probable leuC, 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33). Highly similar to many 3-isopropylmalate dehydratase large subunits involved in leucine biosynthesis, including: Escherichia coli SW:LEU2_ECOLI (P30127) (465 aa), Fasta scores: E(): 0, 61.3% identity in 463 aa overlap and Mycobacterium tuberculosis Rv2988c SW:LEU2_MYCTU (O53237) (473 aa), Fasta scores: E(): 0, 88.7% identity in 471 aa overlap. Contains Pfam match to entry PF00330 aconitase, Aconitase family (aconitate hydratase). Contains PS01244 Aconitase family signature 2. Contains PS00450 Aconitase family signature 1. O33123 No intermediary metabolism and respiration PF00330 O33123 GO:0051539,GO:0005506,GO:0009098,GO:0003861 4.2.1.33 Rv2988c Rv2988c AL450380.2 Mycobrowser_v4 CDS 2861609 2862481 . - 0 ML2391c mca Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) ML2391c, len: 290 aa. Probable mca, mycothiol conjugate amidase. Similar to Mycobacterium tuberculosis mca, mycothiol conjugate amidase Rv1082 TR:O53430 (EMBL:AL021897) (288 aa) fasta scores: E(): 0, 86.4% identity in 287 aa. Also weakly similar to Streptomyces lincolnensis lmbE TR:Q54358 (EMBL:X79146) (270 aa) fasta scores: E(): 8.9e-13, 33.0% identity in 282 aa. Also similar to ML1495 from M. leprae. Q7APV3 No virulence, detoxification, adaptation PF02585 Q7APV3 Rv1082 Rv1082 AL450380.2 Mycobrowser_v4 CDS 2681384 2682490 . - 0 ML2257c menE POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) ML2257c, len: 368 aa. Possible menE, o-succinylbenzoic acid-CoA ligase (EC 6.2.1.26). Similar to Mycobacterium tuberculosis MenE or Rv0542c or MTCY25D10.21C TR:O06408 (EMBL:Z95558) fasta scores: E(): 0, 78.3% identity in 359 aa, and to Escherichia coli o-succinylbenzoic acid--coa ligase MENE SW:MENE_ECOLI (P37353; P78253; P78178) fasta scores: E(): 7e-18, 30.0% identity in 377 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Q9CBB8 No intermediary metabolism and respiration PF00501 Q9CBB8 GO:0008152,GO:0016874 Rv0542c Rv0542c AL450380.2 Mycobrowser_v4 CDS 2932070 2932957 . + 0 ML2459 pcaA MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) ML2459, len: 295 aa. Probable pcaA, Mycolic acid synthase. Highly similar to many mycobacterial mycolic acid synthases including: pcaA|Rv0470c Mycobacterium tuberculosis pcaA, Mycolic acid synthase Rv3392c SW:CFA1_MYCTU (Q11195) (287 aa), fasta scores: E(): 0, 69.0% identity in 287 aa and to Mycobacterium bovis Q7U1X4 Mycolic acid synthase PCAA (287 aa), fasta scores: E(): 5.9e-112, (81.882% identity in 287 aa overlap). Also similar to ML1900 and ML1903 from M. leprae. Q9CB40 No lipid metabolism PF02353 Q9CB40 GO:0008610,GO:0008825 Rv0470c Rv0470c AL450380.2 Mycobrowser_v4 CDS 3204719 3209548 . + 0 ML2671 ctpI PROBABLE CATION-TRANSPORTER ATPASE I CTPI ML2671, len: 1609 aa. Probable ctpI, cation transporter ATPase (EC 3.6.3.-). Similar to Mycobacterium tuberculosis Rv0107c|ctpI probable cation-transporting ATPase I SW:CTPI_MYCTU (Q10900) fasta scores: E(): 0, 81.9% in 1573 aa, and the C-terminal region is similar to to Synechococcus sp cation-transporting ATPase PacL SW:ATCL_SYNP7 (P37278) fasta scores: E(): 9.3e-26, 29.4% in 958 aa. Contains 2 Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPase. Contains PS00154 E1-E2 ATPases phosphorylation site. O53114 No cell wall and cell processes PF00122,PF00689,PF00702 O53114 GO:0006754,GO:0016021,GO:0000287,GO:0015693,GO:0015444,GO:0005886,GO:0005524 3.6.3.- Rv0107c Rv0107c AL450380.2 Mycobrowser_v4 CDS 2099988 2100926 . - 0 ML1740c ML1740c PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE ML1740c, len: 312 aa. Probable oxidoreductase, probably short-chain alcohol dehydrogenase/reductase (EC 1.1.-.-). Similar to several including: Thermotoga maritima 3-oxoacyl-[acyl-carrier protein] reductase SW:FABG_THEMA (Q9X248) (246 aa), Fasta scores: E(): 1.4e-18, 33.2% identity in 193 aa overlap and Mycobacterium tuberculosis possible ketoacyl reductase Rv3057c TR:P95101 (EMBL:Z83866) (287 aa), Fasta scores: E(): 0, 81.8% identity in 280 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Q9CBP7 No intermediary metabolism and respiration PF00106 Q9CBP7 GO:0008152,GO:0016491,GO:0005488 Rv3057c Rv3057c AL450380.2 Mycobrowser_v4 CDS 2948774 2949289 . + 0 ML2474 ML2474 possible cytidine/deoxycytidylate deaminase ML2474, len: 171 aa. Possible cytidine/deoxycytidylate deaminase (EC 3.5.4.-). Similar to several including: Mycobacterium tuberculosis probable cytidine/deoxycytidylate deaminase Rv3752c TR:O69719 (EMBL:AL022121) fasta scores: E(): 0, 87.4% identity in 151 aa, and to Neisseria meningitidis putative cytosine deaminase TR:CAB84390 (EMBL:AL162755) fasta scores: E(): 2e-19, 42.9% identity in 147 aa. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. Q9CB32 No intermediary metabolism and respiration PF00383 Q9CB32 GO:0008270,GO:0016787 Rv3752c Rv3752c AL450380.2 Mycobrowser_v4 CDS 2121326 2122234 . - 0 ML1752c ML1752c conserved hypothetical protein ML1752c, len: 302 aa. Conserved hypothetical protein. Similar to many including the C-terminus of several putative phosphodiesterases e.g. Streptomyces coelicolor TR:Q9Z584 (EMBL:AL035569) (746 aa), Fasta scores: E(): 2.5e-32, 38.4% identity in 305 aa overlap as well as several proteins of undefined function e.g. Mycobacterium tuberculosis Rv1357c SW:YD57_MYCTU (Q11027) (307 aa), Fasta scores: E(): 0, 73.9% identity in 261 aa overlap. Also similar to the C-terminus of ML1750 from M. leprae. Contains Pfam match to entry PF00563 DUF2, Domain of unknown function 2. Q9CBP4 No conserved hypotheticals PF00563 Q9CBP4 Rv1357c Rv1357c AL450380.2 Mycobrowser_v4 CDS 2176926 2177909 . - 0 ML1798c ML1798c Possible transport system kinase ML1798c, len: 327 aa. Possible transport system kinase. Similar to M. tuberculosis Rv1496 SW:YE96_MYCTU (P71777) (334 aa), Fasta scores: E(): 0, 83.0% identity in 323 aa overlap and to other members of the argK family e.g. SW:ARGK_ECOLI (P27254) (331 aa), Fasta scores: E(): 0, 44.9% identity in 321 aa overlap LAO/AO transport system kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBM8 No cell wall and cell processes PF03308 Q9CBM8 GO:0016301 Rv1496 Rv1496 AL450380.2 Mycobrowser_v4 CDS 3107555 3108394 . + 0 ML2603 ML2603 POSSIBLE LYSOPHOSPHOLIPASE ML2603, len: 279 aa. Possible lysophospholipase (EC 3.1.-.-). Similar to Mycobacterium tuberculosis possible lysophospholipase Rv0183 TR:O07427 (EMBL:Z97050) fasta scores: E(): 0, 74.9% identity in 279 aa, and to several putative lipases e.g. Deinococcus radiodurans TR:Q9RU57 (EMBL:AE001997) fasta scores: E(): 2.1e-27, 36.4% identity in 275 aa. Q9CD03 No intermediary metabolism and respiration PF00561 Q9CD03 Rv0183 Rv0183 AL450380.2 Mycobrowser_v4 CDS 2198962 2200599 . - 0 ML1816c ML1816c PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER ML1816c, len: 545 aa. Possible macrolide-transport ATP-binding protein ABC transporter. Similar to M. tuberculosis Rv1473 TR:O53164 (EMBL:AL021184) (542 aa), Fasta scores: E(): 0, 87.9% identity in 545 aa overlap, and to many others e.g. Haemophilus influenzae hypothetical ABC transporter ATP-binding protein SW:YHES_HAEIN (P44808) (638 aa), Fasta scores: E(): 1.4e-30, 31.5% identity in 518 aa overlap. Also similar to ML1248, ML0669, ML0848, ML2189, ML1122, ML0114 and ML0336 from M. leprae. Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Contains 2 x PS00211 ABC transporters family signature. Q9CBL2 No cell wall and cell processes PF00005 Q9CBL2 GO:0016887,GO:0005524 Rv1473 Rv1473 AL450380.2 Mycobrowser_v4 CDS 2533165 2533785 . - 0 ML2131c pdxH PROBABLE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE PDXH (PNP/PMP OXIDASE) (PYRIDOXINEPHOSPHATE OXIDASE) (PNPOX) (PYRIDOXINE 5'-PHOSPHATE OXIDASE) ML2131c, len: 206 aa. Probable pdxH, pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5). Similar to Mycobacterium tuberculosis pyridoxamine 5'-phosphate oxidase Rv2607 SW:PDXH_MYCTU (O06207) fasta scores: E(): 0, 69.3% in 205 aa, and to Escherichia coli pyridoxamine 5'-phosphate oxidase SW:PDXH_ECOLI (P28225) fasta scores: E(): 9.8e-27, 43.3% in 171 aa. Contains Pfam match to entry PF01243 Pyridox_oxidase, Pyridoxamine 5'-phosphate oxidase. Contains PS01064 Pyridoxamine 5'-phosphate oxidase signature. O33065 No intermediary metabolism and respiration PF01243,PF10590 O33065 GO:0055114,GO:0004733,GO:0008615,GO:0010181 1.4.3.5 Rv2607 Rv2607 AL450380.2 Mycobrowser_v4 CDS 2546242 2547030 . - 0 ML2144A ML2144A putative glutathione S-transferase(pseudogene) ML2144A, len:788. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-54 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2543933 2545672 . + 0 ML2143 ML2143 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN ML2143, len: 579 aa. Possible conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 57.9 kda protein Rv0876c SW:Y876_MYCTU (Q10564) fasta scores: E(): 0, 81.2% in 568 aa, and to Streptomyces coelicolor putative integral membrane protein TR:CAB93403 (EMBL:AL357524) fasta scores: E(): 5.3e-16, 38.8% in 448 aa. Contains possible membrane spanning hydrophobic domains. O33057 No cell wall and cell processes O33057 GO:0005886,GO:0016021 Rv0876c Rv0876c AL450380.2 Mycobrowser_v4 CDS 2726917 2727591 . + 0 ML2302 ML2302 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY CRP/FNR-FAMILY) ML2302, len: 224 aa. Probable transcriptional regulatory protein (Crp/Fnr family). Similar to Mycobacterium tuberculosis putative transcriptional regulator Rv3676 or MTV025.024 TR:O69644 (EMBL:AL022121) (224 aa) fasta scores: E(): 0, 96.0% identity in 224 aa. Similar to many e.g. Haemophilus influenzae catabolite gene activator crp or cap or HI0957 SW:CRP_HAEIN (P29281) (224 aa) fasta scores: E(): 2.4e-14, 32.6% identity in 187 aa. Also similar to ML2345 a possible pseudogene similar to M. tuberculosis Rv3676. Contains a probable helix-turn-helix motif at aa 175-196 (Score 1990, SD +5.96) Contains Pfam match to entry PF00325 crp, Bacterial regulatory proteins, crp family. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain. Q9CB91 No regulatory proteins PF00027,PF00325 Q9CB91 GO:0006355,GO:0003700,GO:0005622 Rv3676 Rv3676 AL450380.2 Mycobrowser_v4 CDS 2728463 2728918 . - 0 ML2304c ML2304c conserved hypothetical protein ML2304c, len: 151 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv3678c or MTV025.026C TR:O69646 (EMBL:AL022121) (151 aa) fasta scores: E(): 0, 78.1% identity in 151 aa. Similar to Streptomyces coelicolor hypothetical protein SCH17.09C TR:Q9XA38 (EMBL:AL079353) (155 aa) fasta scores: E(): 1.7e-31, 64.7% identity in 150 aa. Also similar to eukaryotic proteins Trypanosoma cruzi Pb5 pb5 TR:O96876 (EMBL:U67906) (160 aa) fasta scores: E(): 3.4e-20, 50.7% identity in 150 aa and to Leishmania major hypothetical protein l7276.02 TR:Q9U0W7 (EMBL:AL133436) (163 aa) fasta scores: E(): 1.6e-16, 46.1% identity in 152 aa. Contains Pfam match to entry PF01042 UPF0076, Domain of unknown function. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Note start changed since original submission. Q9CB89 No conserved hypotheticals PF01042 Q9CB89 Rv3678c Rv3678c AL450380.2 Mycobrowser_v4 CDS 2494509 2495789 . + 0 ML2098 mntH DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) ML2098, len: 426 aa. Probable mntH (alternative gene name: Nramp, Mramp), H+-dependent divalent cation-transport integral membrane protein. Similar to Mycobacterium tuberculosis mntH, H+-dependent divalent cation-transport integral membrane protein SW:MNTH_MYCTU (O05916) (428 aa), fasta scores: E(): 0, 74.8% in 413 aa, and to Bacillus subtilis probable manganese transport protein mntH SW:MNTH_BACSU (P96593) fasta scores: E(): 0, 44.1% in 415 aa, and to Salmonella typhimurium manganese transport protein mnth SW:MNTH_SALTY (Q9RPF4) fasta scores: E(): 0, 43.1% in 406 aa. Contains Pfam match to entry PF01566 Nramp, Natural resistance-associated macrophage protein. Q50103 No cell wall and cell processes PF01566 Q50103 GO:0030145,GO:0006828,GO:0005886,GO:0015293,GO:0016021 Rv0924c Rv0924c AL450380.2 Mycobrowser_v4 CDS 2169842 2170343 . + 0 ML1793A ML1793A hypothetical protein(pseudogene) ML1793A, len:501. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-14 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2190485 2191618 . - 0 ML1810c moxR1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN MOXR1 ML1810c, len: 377 aa. Probable moxR1, transcriptional regulatory protei. Similar to M. tuberculosis moxR Rv1479 TR:O53170 (EMBL:AL021184) (377 aa), Fasta scores: E(): 0, 90.2% identity in 377 aa overlap, to many other moxR homologs and to e.g. Pyrococcus abyssi MOXR-3 TR:Q9UZ67 (EMBL:AJ248287) (314 aa), Fasta scores: E(): 0, 46.6% identity in 313 aa overlap. Contains Pfam match to entry PF01078 Mg_chelatase, Magnesium chelatase, subunit ChlI. Q9CBL7 No regulatory proteins PF07726 Q9CBL7 GO:0016887,GO:0005524 Rv1479 Rv1479 AL450380.2 Mycobrowser_v4 CDS 2915136 2916461 . - 0 ML2440c senX3 PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 ML2440c, len: 441 aa. Probable senX3, two-component system sensor histidine kinase (EC 2.7.3.-). Similar to many proposed two-component sensor histiding kinases including: Mycobacterium tuberculosis sensor-like histidine kinase SenX3 Rv0490 SW:SEX3_MYCTU (Q11155) (410 aa) fasta scores: E(): 0, 84.0% identity in 406 aa, and to Mycobacterium bovis sensor-like histidine kinase SenX3 SW:SEX3_MYCBO (O07129) (410 aa) fasta scores: E(): 0, 83.7% identity in 406 aa. Contains Pfam match to entry PF00512 signal, Histidine kinase. P54883 No regulatory proteins PF00512,PF02518 P54883 GO:0016021,GO:0018106,GO:0005886,GO:0000155,GO:0000160,GO:0005524 2.7.13.3 Rv0490 Rv0490 AL450380.2 Mycobrowser_v4 CDS 2575972 2577681 . + 0 ML2167 pdc PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC ML2167, len: 569 aa. Probable pdc, pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-). Highly similar to Mycobacterium tuberculosis Rv0853c putative pyruvate/indole-pyruvate carboxylase TR:O53865 (EMBL:AL022004) fasta scores: E(): 0, 79.2% in 543 aa, and to Enterobacter cloacae indole-3-pyruvate decarboxylase SW:DCIP_ENTCL (P23234) fasta scores: E(): 0, 47.8% in 550 aa, and to Saccharomyces cerevisiae pyruvate decarboxylase isozyme 3 SW:DCP3_YEAST (P26263) fasta scores: E(): 0, 38.1% in 557 aa. Also similar to ML1696 and ML2083 from M. leprae. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CBD6 No intermediary metabolism and respiration PF00205,PF02775,PF02776 Q9CBD6 GO:0000287,GO:0030976,GO:0016831 4.1.1.- Rv0853c Rv0853c AL450380.2 Mycobrowser_v4 CDS 2647530 2648948 . - 0 ML2230c purB INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE EIGHT STEP) [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-4-(N-SUCCINO-CARBOXAMIDE) -5-AMINOIMIDAZOLE = FUMARATE + 5'-PHOSPHORIBOSYL-5-AMINO-4-IMIDAZOLECARBOXAMIDE (ALSO CATALYZES: N6-(1,2-DICARBOXYETHYL)AMP = FUMARATE + AMP)]. PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) (ASL) (ASASE) ML2230c, len: 472 aa. Probable purB, adenylosuccinate lyase (EC 4.3.2.2). Similar to Mycobacterium tuberculosis hypothetical 51.0 kda protein cy369.21b Rv0777 OR MTCY369.21B TR:P71832 (EMBL:Z80226) fasta scores: E(): 0, 86.4% identity in 472 aa, and to Saccharomyces cerevisiae adenylosuccinate lyase ADE13 OR YLR359W OR L8039.12 SW:PUR8_YEAST (Q05911) fasta scores: E(): 0, 34.5% identity in 449 aa. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature. Q9CBC1 No intermediary metabolism and respiration PF00206,PF10397 Q9CBC1 GO:0009152,GO:0004018 Rv0777 Rv0777 AL450380.2 Mycobrowser_v4 CDS 2653344 2654612 . - 0 ML2235c purD PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) ML2235c, len: 422 aa. Probable purD, phosphoribosylamine-glycine ligase(EC 6.3.4.13). Similar to Mycobacterium tuberculosis phosphoribosylamine--glycine ligase PurD OR Rv0772 OR MTCY369.17 SW:PUR2_MYCTU (P71827) fasta scores: E(): 0, 81.8% identity in 418 aa, and to Salmonella typhimurium phosphoribosylamine--glycine ligase PurD SW:PUR2_SALTY (P26977) fasta scores: E(): 0, 43.2% identity in 426 aa. Contains Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase (GARS). Contains PS00184 Phosphoribosylglycinamide synthetase signature. Q50144 No intermediary metabolism and respiration PF01071,PF02843,PF02844 Q50144 GO:0000287,GO:0030145,GO:0004637,GO:0009113,GO:0006164,GO:0005524 6.3.4.13 Rv0772 Rv0772 AL450380.2 Mycobrowser_v4 CDS 2959468 2960016 . - 0 ML2485c ML2485c POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE) ML2485c, len: 182 aa. Possible RNA methyltransferase (EC 2.1.1.-). Similar to Mycobacterium tuberculosis hypothetical protein Rv0380c TR:O53715 (EMBL:AL021931) fasta scores: E(): 0, 89.0% identity in 182 aa, and to Escherichia coli SpoU SW:TRMH_ECOLI (P19396) fasta scores: E(): 6.1e-07, 26.2% identity in 164 aa. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family. Q9CB29 No intermediary metabolism and respiration PF00588 Q9CB29 GO:0008173,GO:0006396,GO:0003723 Rv0380c Rv0380c AL450380.2 Mycobrowser_v4 CDS 2903588 2904682 . - 0 ML2428c galE2 POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE) ML2428c, len: 364 aa. Possible galE2, UDP-glucose 4-epimerase (EC 5.1.3.2). Similar to Mycobacterium tuberculosis UDP-glucose 4-epimerase Rv0501 SW:Y501_MYCTU (Q11166) (376 aa) fasta scores: E(): 0, 84.0% identity in 368 aa, and to Streptomyces violaceoruber dTDP-glucose dehydratase TR:Q56173 (EMBL:L37334) (321 aa) fasta scores: E(): 2.9e-07, 30.4% identity in 332 aa. Q9CB57 No intermediary metabolism and respiration PF01370 Q9CB57 GO:0044237,GO:0050662,GO:0003824 Rv0501 Rv0501 AL450380.2 Mycobrowser_v4 CDS 2172974 2173242 . + 0 ML1794A ML1794A hypothetical protein(pseudogene) ML1794A, len:268. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2909080 2910099 . - 0 ML2434c ML2434c conserved hypothetical protein ML2434c, len: 339 aa. Conserved hypothetical protein. Similar to many including: Mycobacterium tuberculosis hypothetical protein Rv0496 SW:Y496_MYCTU (Q11161) (328 aa) fasta scores: E(): 0, 85.6% identity in 327 aa. Also weakly similar to several exopolyphosphatases involved in the degradation of inorganic polyphosphates e.g. Escherichia coli exopolyphosphatase ppx SW:PPX_ECOLI (P29014) (512 aa) fasta scores: E(): 8.4e-09, 22.5% identity in 298 aa. P54882 No conserved hypotheticals PF02541 P54882 GO:0016787 Rv0496 Rv0496 AL450380.2 Mycobrowser_v4 CDS 2924649 2925464 . + 0 ML2449 ML2449 POSSIBLE AMIDOHYDROLASE ML2449, len: 271 aa. Possible amidohydrolase. Similar to several including: Mycobacterium tuberculosis amidohydrolase Rv0480c SW:Y480_MYCTU (Q11146) (280 aa), fasta scores: E(): 0, 81.9% identity in 270 aa, and to Streptomyces coelicolor putative hydrolase TR:Q9XA70 (EMBL:AL096822) fasta scores: E(): 1.5e-16, 34.9% identity in 272 aa. Contains Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase. Contains PS01227 Uncharacterized protein family UPF0012 signature. Q9CB47 No intermediary metabolism and respiration PF00795 Q9CB47 GO:0006807,GO:0016810 Rv0480c Rv0480c AL450380.2 Mycobrowser_v4 CDS 2925770 2926507 . + 0 ML2450 ML2450 possible secreted protein ML2450, len: 245 aa. Possible secreted protein. Similar to the C-terminal region of Mycobacterium tuberculosis hypothetical protein Rv0479c SW:Y479_MYCTU (Q11145) (348 aa), fasta scores: E(): 0, 70.0% identity in 243 aa. Contains a possible N-terminal signal sequence. Q9CB46 No cell wall and cell processes Q9CB46 Rv0479c Rv0479c AL450380.2 Mycobrowser_v4 CDS 2947166 2948149 . - 0 ML2472c tyrA PREPHENATE DEHYDROGENASE TYRA (PDH) (HYDROXYPHENYLPYRUVATE SYNTHASE) ML2472c, len: 327 aa. Probable tyrA, prephenate dehydrogenase (EC 1.3.1.12). Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% identity in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% identity in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. Q9CB34 No intermediary metabolism and respiration PF02153 Q9CB34 GO:0004665,GO:0006571,GO:0005488 Rv3754 Rv3754 AL450380.2 Mycobrowser_v4 CDS 2930186 2930887 . + 0 ML2457 ML2457 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) ML2457, len: 233 aa. Probable regulatory protein, possibly tetR family. Similar to several putative trancriptional regulators e.g. Mycobacterium tuberculosis putative regulatory protein Rv0472c TR:O53757 (EMBL:AL021933) fasta scores: E(): 0, 88.8% identity in 232 aa. Contains a helix-turn-helix motif situated between residues 45..66 (+3.77 SD). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Q9CB41 No regulatory proteins PF00440 Q9CB41 GO:0003700,GO:0006355 Rv0472c Rv0472c AL450380.2 Mycobrowser_v4 CDS 2969306 2969704 . - 0 ML2493c hspR PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL REPRESSOR HSPR (MERR FAMILY) ML2493c, len: 132 aa. Probable hspR, heat shock transcriptional repressor. Similar to Mycobacterium tuberculosis HspR OR Rv0353 TR:O06302 (EMBL:Z95324) fasta scores: E(): 0, 80.0% identity in 125 aa, and to Streptomyces albus TR:P96458 (EMBL:U43299) fasta scores: E(): 3.9e-20, 50.0% identity in 152 aa. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family. Q9CB24 No virulence, detoxification, adaptation PF00376 Q9CB24 GO:0006355,GO:0006950,GO:0003700,GO:0000166 Rv0353 Rv0353 AL450380.2 Mycobrowser_v4 CDS 3122276 3122788 . - 0 ML2616c ML2616c conserved hypothetical protein ML2616c, len: 170 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0201c TR:O53652 (EMBL:AL021928) fasta scores: E(): 0, 63.9% identity in 158 aa. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Q7APT0 No conserved hypotheticals Q7APT0 Rv0201c Rv0201c AL450380.2 Mycobrowser_v4 CDS 2974628 2975287 . + 0 ML2498 ML2498 possible enoyl-CoA hydratase ML2498, len: 219 aa. Possible enoyl-CoA hydratase (EC 5.-.-.-). Similar to several proteins belonging to the enoyl-CoA hydratase/isomerase family e.g. Arabidopsis thaliana carnitine racemase homolog TR:O23300 (EMBL:Z97336) fasta scores: E(): 1.7e-17, 36.0% identity in 203 aa and Escherichia coli carnitine racemase CAID CAID_ECOLI|P31551|P75623 fasta scores: E(): 2.9e-08, 29.0% identity in 214 aa. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Q9CB21 No lipid metabolism PF00378 Q9CB21 GO:0008152,GO:0003824 AL450380.2 Mycobrowser_v4 CDS 2987957 2988529 . - 0 ML2507c dcd PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) ML2507c, len: 190 aa. Probable dcd, deoxycytidine triphosphate deaminase (EC 3.5.4.13). Similar to Mycobacterium tuberculosis deoxycytidine triphosphate deaminase Rv0321 SW:DCD_MYCTU (O07247) fasta scores: E(): 0, 89.5% identity in 190 aa and to Escherichia coli deoxycytidine triphosphate deaminase SW:DCD_ECOLI (P28248) fasta scores: E(): 7.5e-20, 42.6% identity in 188 aa. Contains Pfam match to entry PF00692 dUTPase, dUTPase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CB17 No intermediary metabolism and respiration PF00692 Q9CB17 GO:0006229,GO:0009220,GO:0008829 3.5.4.13 Rv0321 Rv0321 AL450380.2 Mycobrowser_v4 CDS 2561500 2561636 . - 0 ML2157A ML2157A hypothetical protein(pseudogene) ML2157A, len:136. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3053230 3053718 . - 0 ML2561c ML2561c POSSIBLE OXIDOREDUCTASE ML2561c, len: 162 aa. Possible oxidoreductase. Similar to many including: Mycobacterium tuberculosis Possible oxidoreductase Rv0245 OR MTV034.11 TR:O53667 (EMBL:AL021929) fasta scores: E(): 0, 82.0% identity in 161 aa and Streptomyces pristinaespiralis NADH:riboflavin 5'-phosphate oxidoreductase SNAC SW:SNAC_STRPR (P54994) fasta scores: E(): 2.7e-10, 31.6% identity in 158 aa. Contains Pfam match to entry PF01613 Flavin_Reduct, Flavin reductase like domain. Q7APU5 No intermediary metabolism and respiration PF01613 Q7APU5 GO:0009055,GO:0016491,GO:0010181 Rv0245 Rv0245 AL450380.2 Mycobrowser_v4 CDS 3063966 3065129 . - 0 ML2569c lpqI PROBABLE CONSERVED LIPOPROTEIN LPQI ML2569c, len: 387 aa. Probable lpqI, conserved lipoprotein. Similar to several e.g. Mycobacterium tuberculosis conserved lipoprotein Rv0237 TR:O53660 (EMBL:AL021929) fasta scores: E(): 0, 73.2% identity in 392 aa. Also similar in regions to several beta-hexosaminidase e.g. Alteromonas sp SW:HEXA_ALTSO (P48823) fasta scores: E(): 4.1e-17, 30.0% identity in 333 aa. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00933 Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain. Q7APU0 No cell wall and cell processes PF00933 Q7APU0 GO:0004553,GO:0005975 Rv0237 Rv0237 AL450380.2 Mycobrowser_v4 CDS 3093776 3094816 . + 0 ML2590 mce1B MCE-FAMILY PROTEIN MCE1B ML2590, len: 346 aa. mce1B, Mce-family protein. Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. Rv0170 TR:O07414 (EMBL:Z97050) fasta scores: E(): 0, 75.1% identity in 346 aa. Orthologue of M. tuberculosis mce1B (Rv0170). Contains a possible N-terminal signal sequence. Q9CD13 No virulence, detoxification, adaptation PF02470 Q9CD13 Rv0170 Rv0170 AL450380.2 Mycobrowser_v4 CDS 3096369 3097964 . + 0 ML2592 mce1D MCE-FAMILY PROTEIN MCE1D ML2592, len: 531 aa. mce1D, Mce-family protein. Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. Rv0172 TR:O07416 (EMBL:Z97050) fasta scores: E(): 0, 78.1% identity in 534 aa. Orthologue of M. tuberculosis Mce1D (Rv0172). Contains a possible N-terminal signal sequence. Q9CD11 No virulence, detoxification, adaptation PF02470 Q9CD11 Rv0172 Rv0172 AL450380.2 Mycobrowser_v4 CDS 1323065 1323295 . + 0 ML1131A ML1131A hypothetical protein(pseudogene) ML1131A, len:230. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-19 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3221704 3222414 . + 0 ML2677 ML2677 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN ML2677, len: 236 aa. Probable transcriptional regulatory protein (TetR-family). Similar to several putative transcriptional regulators including: Mycobacterium tuberculosis transcriptional regulator Rv0078 TR:O53623 (EMBL:AL021428) fasta scores: E(): 0, 71.4% in 175 aa, and Streptomyces coelicolor putative transcriptional regulatory protein TR:CAB76360 (EMBL:AL158061) fasta scores: E(): 0.048, 25.4% in 201 aa. Contains a probable helix-turn-helix motif at aa 35-56 (Score 1329, SD +3.71) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Q7APS2 No regulatory proteins PF00440 Q7APS2 GO:0003700,GO:0006355 Rv0078 Rv0078 AL450380.2 Mycobrowser_v4 CDS 1298899 1299416 . + 0 ML1120A ML1120A hypothetical protein(pseudogene) ML1120A, len:517. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-20 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2982840 2984153 . + 0 ML2502 aspC PROBABLE ASPARTATE AMINOTRANSFERASE ASPC (TRANSAMINASE A) (ASPAT) ML2502, len: 437 aa. Probable aspC, aspartate aminotransferase (EC 2.6.1.1). Similar to Mycobacterium tuberculosis probable aspartate aminotransferase Rv0337c SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% identity in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% identity in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. Q9CB19 No intermediary metabolism and respiration PF00155 Q9CB19 GO:0009058,GO:0030170,GO:0008483,GO:0016847 Rv0337c Rv0337c AL450380.2 Mycobrowser_v4 CDS 3233193 3233447 . - 0 ML2683c rpsR PROBABLE 30S RIBOSOMAL PROTEIN S18-1 RPSR ML2683c, len: 84 aa. Probable rpsR, 30S ribosomal protein S18. Similar to Bacillus subtilis 30s ribosomal protein s18 SW:RS18_BACSU (P21475) fasta scores: E(): 7.3e-10, 51.5% in 68 aa, and to Mycobacterium tuberculosis 30s ribosomal protein s18-1 SW:R18A_MYCTU (P71712) fasta scores: E(): 1.5e-30, 90.5% in 84 aa. Contains Pfam match to entry PF01084 Ribosomal_S18, Ribosomal protein S18. Contains PS00057 Ribosomal protein S18 signature. O53125 No information pathways PF01084 O53125 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0055 Rv0055 AL450380.2 Mycobrowser_v4 CDS 2561887 2562284 . - 0 ML2157B ML2157B hypothetical protein(pseudogene) ML2157B, len:397. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-17 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2901524 2902450 . + 0 ML2426 cmaA2 ESSENTIAL FOR THE CYCLOPROPANATION FUNCTION. TRANSFERS A METHYLENE GROUP FROM S-ADENOSYL-L-METHIONINE TO THE CIS DOUBLE BOND OF AN UNSATURATED FATTY ACID CHAIN RESULTING IN THE REPLACEMENT OF THE DOUBLE BOND WITH A METHYLENE BRIDGE. MYCOLIC ACIDS, WHICH REPRESENT THE MAJOR CONSTITUENT OF MYCOBACTERIAL CELL WALL COMPLEX, ACT AS SUBSTRATES [CATALYTIC ACTIVITY: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid]. CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID TRANS-CYCLOPROPANE SYNTHETASE) ML2426, len: 308 aa. Probable cmaA2, cyclopropane mycolic acid synthase 2 (EC 2.1.1.79). Similar to Mycobacterium tuberculosis cyclopropane-fatty-acyl-phospholipid synthase Rv0503c SW:CFA2_MYCTU (Q11196) (302 aa) fasta scores: E(): 0, 78.9% identity in 303 aa. Also similar to ML2459 from M. leprae. Q49807 No lipid metabolism PF02353 Q49807 GO:0005737,GO:0008610,GO:0008825 2.1.1.79 Rv0503c Rv0503c AL450380.2 Mycobrowser_v4 CDS 2971574 2973436 . - 0 ML2496c dnaK PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70) ML2496c, len: 620 aa. Probable dnaK, 70 kD heat shock protein (molecular chaperone) (EC 3.6.1.-). Similar to Mycobacterium paratuberculosis dnak protein SW:DNAK_MYCPA (Q00488) fasta scores: E(): 0, 93.4% identity in 622 aa, and to Mycobacterium tuberculosis dnak protein Rv0350 SW:DNAK_MYCTU (P32723; O06301) fasta scores: E(): 0, 92.5% identity in 624 aa. Contains Pfam match to entry PF00012 HSP70, Hsp70 protein. Contains PS01036 Heat shock hsp70 proteins family signature 3. Contains PS00329 Heat shock hsp70 proteins family signature 2. Contains PS00297 Heat shock hsp70 proteins family signature 1. P19993 No virulence, detoxification, adaptation PF00012 P19993 GO:0006457,GO:0006950,GO:0051082,GO:0005524 Rv0350 Rv0350 AL450380.2 Mycobrowser_v4 CDS 3057494 3058867 . - 0 ML2564c fadA2 PROBABLE ACETYL-CoA ACYLTRANSFERASE FADA2 (3-KETOACYL-CoA THIOLASE) (BETA-KETOTHIOLASE) ML2564c, len: 457 aa. Probable fadA2,acetyl-CoA acetyltransferase (EC ). Similar to many Prokaryotic and Eukaryotic thiolases including: Escherichia coli probable 3-ketoacyl-coa thiolase YFCY SW:YFCY_ECOLI (P76503) fasta scores: E(): 0, 36.9% identity in 434 aa and to Rattus norvegicus trifunctonal enzyme beta subunit, mitochondrial precursor SW:ECHB_RAT (Q60587) fasta scores: E(): 0, 37.2% identity in 462 aa. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00099 Thiolases active site. O69505 No lipid metabolism PF00108,PF02803 O69505 GO:0016740,GO:0008152 Rv0243 Rv0243 AL450380.2 Mycobrowser_v4 CDS 1306546 1306773 . - 0 ML1125A ML1125A hypothetical protein(pseudogene) ML1125A, len:227. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 54698 55039 . + 0 ML0044 espL ESX-1 SECRETION-ASSOCIATED PROTEIN ESPL ML0044, len: 113 aa. ESX-1 secretion-associated protein, highly similar to Rv3880c|O69744|AL123456 ESX-1 secretion-associated protein from M. tuberculosis (115 aa), Fasta scores: E(): 2.6e-21, (56.4% identity in 110 aa overlap). Previously sequenced as O33080|Y14967 (113 aa), Fasta scores: (100.0% identity in 113 aa overlap). Q7AQP2 No cell wall and cell processes Q7AQP2 Rv3880c Rv3880c AL450380.2 Mycobrowser_v4 CDS 2921391 2922716 . - 0 ML2446c lprQ PROBABLE CONSERVED LIPOPROTEIN LPRQ ML2446c, len: 441 aa. Probable lprQ, conserved lipoprotein. Similar to Mycobacterium tuberculosis lipoprotein lprQ Rv0483 SW:Y483_MYCTU (Q11149) fasta scores: E(): 0, 79.3% identity in 439 aa, and to Streptomyces coelicolor putative lipoprotein TR:CAB76012 (EMBL:AL157916) fasta scores: E(): 2.5e-24, 28.6% identity in 405 aa. Also similar to ML0426 from M. leprae. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CB49 No cell wall and cell processes PF03734 Q9CB49 Rv0483 Rv0483 AL450380.2 Mycobrowser_v4 CDS 3092454 3093779 . + 0 ML2589 mce1A MCE-FAMILY PROTEIN MCE1A ML2589, len: 441 aa. Probable mce1A, Mce-family protein. Highly similar to Mycobacterium tuberculosis Mce proteins associated with entry and survival inside macrophage e.g. Rv0169 ORMTCI28.08 TR:P72013 (EMBL:Z97050) fasta scores: E(): 0, 67.5% identity in 456 aa.Orthologue of M. tuberculosis Mce1A (Rv0169). Contains a possible N-terminal signal sequence. Q9CD14 No virulence, detoxification, adaptation PF02470 Q9CD14 Rv0169 Rv0169 AL450380.2 Mycobrowser_v4 CDS 3145235 3145606 . - 0 ML2630c ML2630c conserved hypothetical protein ML2630c, len: 123 aa. Conserved hypothetical protein. Highly similar in part to another Mycobacterium leprae hypothetical protein ML0007 TR:O32870 (EMBL:Z70722) fasta scores: E(): 2.7e-28, 96.6% identity in 88 aa. Note this is a possible pseudogene likely to have been formed as a consequence of a duplication event. Also similar in part to P71575|Y007_MYCTU|Rv0007 Hypothetical protein from M. tuberculosis (304 aa), fasta scores: E(): 1.1, (36.667% identity in 90 aa overlap). O06091 No conserved hypotheticals O06091 AL450380.2 Mycobrowser_v4 CDS 3131789 3132376 . - 0 ML2621c ML2621c CONSERVED HYPOTHETICAL PROTEIN ML2621c, len: 195 aa. Conserved hypothetical protein. Similar except shorter to Mycobacterium tuberculosis hypothetical protein Rv0207c TR:P96389 (EMBL:Z92669) fasta scores: E(): 0, 60.8% identity in 199 aa, and weakly similar to Schizosaccharomyces pombe hypothetical protein TR:O74960 (EMBL:AL023705) fasta scores: E(): 1, 22.2% id in 248 aa. Q9CD00 No conserved hypotheticals Q9CD00 Rv0207c Rv0207c AL450380.2 Mycobrowser_v4 CDS 3232687 3233145 . - 0 ML2682c rplI PROBABLE 50S RIBOSOMAL PROTEIN L9 RPLI ML2682c, len: 152 aa. Probable rplI, 50S ribosomal protein L9. Similar to Mycobacterium tuberculosis 50s ribosomal protein l9 SW:RL9_MYCTU (P71713) fasta scores: E(): 0, 88.7% in 150 aa, and to Escherichia coli 50s ribosomal protein l9 SW:RL9_ECOLI (P02418) fasta scores: E(): 1.3e-12, 41.1% in 151 aa. Contains Pfam match to entry PF01281 Ribosomal_L9, Ribosomal protein L9. Contains PS00651 Ribosomal protein L9 signature. P46385 No information pathways P46385 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0056 Rv0056 AL450380.2 Mycobrowser_v4 CDS 3169333 3170148 . - 0 ML2649c ML2649c Putative oligosaccharide deacetylase ML2649c, len: 271 aa. Putative oligosaccharide deacetylase. Weakly similar to others e.g. Streptomyces coelicolor putative oligosaccharide deacetylase TR:Q9RCX4 (EMBL:AL133469) fasta scores: E(): 4.5e-10, 30.9% in 165 aa, and to Bacillus cereus polysaccharide deacetylase-like protein TR:Q9XBJ5 (EMBL:AJ010139) fasta scores: E(): 2.4e-07, 26.6% in 241 aa. Contains Pfam match to entry PF01522 Polysac_deacet, Polysaccharide deacetylase. Contains PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. Q9CCZ2 No intermediary metabolism and respiration PF01522 Q9CCZ2 GO:0016810,GO:0005975 AL450380.2 Mycobrowser_v4 CDS 3100817 3101365 . + 0 ML2595 ML2595 PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN ML2595, len: 182 aa. Probable conserved Mce associated membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0175 TR:O07419 (EMBL:Z97050) fasta scores: E(): 0, 70.5% identity in 166 aa. Orthologue of M. tuberculosis Rv0175. Contains a possible membrane spanning hydrophobic domain. Q9CD08 No cell wall and cell processes Q9CD08 Rv0175 Rv0175 AL450380.2 Mycobrowser_v4 CDS 83900 84046 . + 0 ML0062A ML0062A hypothetical protein(pseudogene) ML0062A, len:146. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-17 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3126443 3127501 . - 0 ML2618c ML2618c probable integral membrane protein ML2618c, len: 352 aa. Probable integral membrane protein. Similar to several proteins of undefined function including: Mycobacterium tuberculosis Rv0204c TR:O53655 (EMBL:AL021928) fasta scores: E(): 0, 82.6% identity in 374 aa, and to Methanobacterium thermoautotrophicum SW:YC61_METTH (O27329) fasta scores: E(): 0.00014, 24.7% identity in 324 aa. Contains a possible N-terminal signal sequence and several other possible membrane spanning hydrophobic domains. Q9CD01 No cell wall and cell processes PF03706 Q9CD01 Rv0204c Rv0204c AL450380.2 Mycobrowser_v4 CDS 3153219 3154322 . - 0 ML2636c pntAa PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAA [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) ML2636c, len: 367 aa. Probable pntAa, pyridine transhydrogenase subunit [alpha]1 (EC 1.6.1.2). Similar to Mycobacterium tuberculosis PntAa OR Rv0155 TR:P96832 (EMBL:Z92770) fasta scores: E(): 0, 87.9% identity in 365 aa, Haemophilus influenzae NAD PntA SW:PNTA_HAEIN (P43842) fasta scores: E(): 0, 42.6% identity in 364 aa, and to Escherichia coli NAD PntA SW:PNTA_ECOLI (P07001; P76888) fasta scores: E(): 0, 42.1% identity in 363 aa. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Q9CCZ6 No intermediary metabolism and respiration PF01262,PF05222 Q9CCZ6 GO:0009055,GO:0008152,GO:0016491,GO:0005488 Rv0155 Rv0155 AL450380.2 Mycobrowser_v4 CDS 3132585 3133277 . - 0 ML2622c ML2622c Probable tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase ) ML2622c, len: 230 aa. Probable tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33). Similar to several e.g. Mycobacterium tuberculosis Rv0208c TR:P96390 (EMBL:Z92669) fasta scores: E(): 0, 64.2% identity in 246 aa, and to Neisseria meningitidis TR:AAF41703 (EMBL:AE002481) fasta scores: E(): 6e-25, 34.9% identity in 232 aa. Belongs to the methyltransferase superfamily. TrmB family. Q9CCZ9 No intermediary metabolism and respiration PF02390 Q9CCZ9 GO:0006400,GO:0008176 2.1.1.33 Rv0208c Rv0208c AL450380.2 Mycobrowser_v4 CDS 3152888 3153226 . - 0 ML2635c pntAb PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAB [SECOND PART; INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) ML2635c, len: 112 aa. Probable pntAB, pyridine transhydrogenase subunit [alpha]2 (EC 1.6.1.2). Similar to Mycobacterium tuberculosis PntAB OR Rv0156 TR:P96833 (EMBL:Z92770) fasta scores: E(): 3.5e-30, 83.0% identity in 100 aa, and to Rhodospirillum rubrum nicotinamide nucleotide transhydrogenase, subunit alpha 2 PntAB TR:Q59764 (EMBL:U01158) fasta scores: E(): 6.1e-11, 42.7% identity in 89 aa. Note this is the equivalent to the very C-terminal hydrophobic domain of the larger E. coli and bovine mitochondrial enzymes. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Q9CCZ7 No intermediary metabolism and respiration Q9CCZ7 Rv0156 Rv0156 AL450380.2 Mycobrowser_v4 CDS 3151473 3152891 . - 0 ML2634c pntB PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA) ML2634c, len: 472 aa. Probable pntB, pyridine transhydrogenase subunit [beta] (EC 1.6.1.1). Similar to Mycobacterium tuberculosis PntB OR Rv0157 TR:P96834 (EMBL:Z92770) fasta scores: E(): 0, 87.3% identity in 473 aa, Rhodospirillum rubrum nicotinamide nucleotide transhydrogenase, subunit beta PntB TR:Q59765 (EMBL:U01158) fasta scores: E(): 0, 46.5% identity in 469 aa and to Escherichia coli NAD PntB SW:PNTB_ECOLI (P07002; P76890) fasta scores: E(): 0, 43.5% identity in 476 aa. Q9CCZ8 No intermediary metabolism and respiration PF02233 Q9CCZ8 GO:0050661,GO:0016021,GO:0008750 Rv0157 Rv0157 AL450380.2 Mycobrowser_v4 CDS 1329874 1329957 . + 0 ML1137A ML1137A hypothetical protein(pseudogene) ML1137A, len:83. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3182083 3183147 . - 0 ML2659c pepA PROBABLE SERINE PROTEASE PEPA (SERINE PROTEINASE) (MTB32A) ML2659c, len: 354 aa. Probable pepA, secreted serine protease (EC 3.4.21.-). Similar to many including: Mycobacterium paratuberculosis serine protease Rv0125 TR:Q50320 (EMBL:Z23092) fasta scores: E(): 0, 71.4% in 364 aa, Mycobacterium tuberculosis hypothetical 34.9 kda protein TR:O07175 (EMBL:Z96071) fasta scores: E(): 0, 70.1% in 358 aa, and to Escherichia coli protease DegS precursor SW:DEGS_ECOLI (P31137) fasta scores: E(): 2.1e-16, 32.0% in 356 aa. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00089 trypsin, Trypsin. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Q9CCY9 No intermediary metabolism and respiration PF00089,PF00595 Q9CCY9 GO:0006508,GO:0004252,GO:0005515 Rv0125 Rv0125 AL450380.2 Mycobrowser_v4 CDS 3233473 3233979 . - 0 ML2684c ssb PROBABLE SINGLE-STRAND BINDING PROTEIN SSB (HELIX-DESTABILIZING PROTEIN) ML2684c, len: 168 aa. Probable ssb, single strand binding protein. Similar to Escherichia coli single-strand binding protein SW:SSB_ECOLI (P02339) fasta scores: E(): 1.4e-09, 32.6% in 172 aa, and to Mycobacterium tuberculosis single-strand binding protein Rv0054 SW:SSB_MYCTU (P71711) fasta scores: E(): 0, 89.3% in 168 aa. Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family. P46390 No information pathways PF00436 P46390 GO:0006260,GO:0003697,GO:0006281 Rv0054 Rv0054 AL450380.2 Mycobrowser_v4 CDS 84112 84676 . - 0 ML0062B ML0062B hypothetical protein(pseudogene) ML0062B, len:564. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-30 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3246791 3247522 . + 0 ML2696 ML2696 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MARR-FAMILY) ML2696, len: 243 aa. POssible transcriptional regulatory protein (MarR-family). Similar to Mycobacterium tuberculosis Rv0042c transcriptional regulatory protein TR:P71699 (EMBL:Z80775) fasta scores: E(): 0, 77.4% in 190 aa, and weakly similar to Streptomyces coelicolor putative MarR-family transcriptional regulator TR:CAB76343 (EMBL:AL158061) fasta scores: E(): 1.9e-07, 32.7% in 147 aa. Contains Pfam match to entry PF01047 MarR, MarR family. Q9CCY2 No regulatory proteins PF01047 Q9CCY2 GO:0006355,GO:0003700,GO:0005622 Rv0042c Rv0042c AL450380.2 Mycobrowser_v4 CDS 3190784 3191539 . + 0 ML2664 ldt POSSIBLE CONSERVED MEMBRANE PROTEIN ML2664, len: 251 aa. Possible conserved membrane protein. Similar to Mycobacterium tuberculosis Rv0116c hypothetical 26.9 kda protein TR:O53638 (EMBL:AL021926) fasta scores: E(): 0, 76.0% in 250 aa, and to Streptomyces coelicolor putative secreted protein TR:Q9X811 (EMBL:AL049497) fasta scores: E(): 6.1e-21, 39.7% in 239 aa. Contains a possible N-terminal signal sequence and another possible membrane-spanning hydrophobic domain. Q7APS5 No cell wall and cell processes PF03734 Q7APS5 Rv0116c Rv0116c AL450380.2 Mycobrowser_v4 CDS 1375734 1375918 . + 0 ML1178A ML1178A fadA3; acetyl-CoA C-acetyltransferase(pseudogene) ML1178A, len:184. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-33 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3157371 3158876 . - 0 ML2639c ML2639c PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT ML2639c, len: 501 aa. Probable aldehyde dehydrogenase (EC 1.2.1.-). Similar to many Prokaryotic and Eukaryotic aldehyde dehydrogenases including: Mycobacterium tuberculosis hypothetical 55.0 kda protein Rv0147 TR:P96824 (EMBL:Z92770) fasta scores: E(): 0, 77.1% identity in 493 aa and Homo sapiens aldehyde dehydrogenase, dimeric NADP-preferring ALDH3 SW:DHAP_HUMAN (P30838) fasta scores: E(): 0, 44.7% identity in 450 aa. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Q9CCZ5 No intermediary metabolism and respiration PF00171 Q9CCZ5 GO:0006081,GO:0004030 Rv0147 Rv0147 AL450380.2 Mycobrowser_v4 CDS 508328 508630 . + 0 ML0410 PE3 PE-family protein ML0410, len: 100 aa. Member of the Mycobacteria PE family. Similar to numerous M. tuberculosis PE-family proteins e.g. Rv2107|O33243|AL123456 PE-family protein (98 aa), Fasta scores: E(): 4.7e-08, (44.7% identity in 85 aa overlap). Also similar to ML0538, ML1183 and ML1414 from M. leprae. Contains Pfam match to entry PF00934 PE, PE family. Q49724 No PE/PPE PF00934 Q49724 AL450380.2 Mycobrowser_v4 CDS 1382329 1382628 . - 0 ML1183c PE6 PE FAMILY PROTEIN ML1183c, len: 99 aa. Member of Mycobacteria PE family. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49943 (EMBL:AL049191) (99 aa), Fasta scores: E(): 0, 100.0% identity in 99 aa overlap. Also highly similar to many Mycobacterium tuberculosis PE family proteins e.g. TR:O05297 (EMBL:Z93777) Rv1195 (99 aa), Fasta scores: E(): 1.3e-12, 48.9% identity in 92 aa overlap and the N-terminus of several PGRS-family proteins also from M. tuberculosis e.g. Rv0742 TR:O53805 (EMBL:AL021958) (175 aa), Fasta scores: E(): 8.8e-09, 39.6% identity in 96 aa overlap. Also similar to ML1053 a possible orthologue of M. tuberculosis Rv1195. Contains Pfam match to entry PF00934 PE, PE family. Q49943 No PE/PPE Q49943 Rv1195 Rv1195 AL450380.2 Mycobrowser_v4 CDS 3166874 3167407 . + 0 ML2647 msrA HAS AN IMPORTANT FUNCTION AS A REPAIR ENZYME FOR PROTEINS THAT HAVE BEEN INACTIVATED BY OXIDATION. CATALYZES THE REVERSIBLE OXIDATION-REDUCTION OF METHIONINE SULFOXIDE IN PROTEINS TO METHIONINE [CATALYTIC ACTIVITY: Protein L-methionine + oxidized thioredoxin = protein L-methionine S-oxide + reduced thioredoxin]. PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) REDUCTASE) ML2647, len: 177 aa. Probable msrA, peptide methionine sulfoxide reductase (EC 1.8.4.6). Similar to regions of several methionine sulfoxide reductases including: Pseudomonas fluorescens putative methionine sulfoxide reductase TR:O69761 (EMBL:L49465) fasta scores: E(): 0, 70.0% in 160 aa, and to Mycobacterium tuberculosis hypothetical 20.5 kda protein Rv0137c TR:P96814 (EMBL:Z92770) fasta scores: E(): 0, 80.0% in 170 aa, and to Escherichia coli peptide methionine sulfoxide reductase SW:PMSR_ECOLI (P27110) fasta scores: E(): 3e-25, 48.4% in 155 aa. Contains Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase. Q9CCZ3 No intermediary metabolism and respiration PF01625 Q9CCZ3 GO:0008113,GO:0006464,GO:0055114 1.8.4.11 Rv0137c Rv0137c AL450380.2 Mycobrowser_v4 CDS 91560 91641 . - 0 ML0070A ML0070A hypothetical protein(pseudogene) ML0070A, len:81. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3135283 3137112 . + 0 ML2624 pckA PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE) ML2624, len: 609 aa. Probable pckA, iron-regulated phosphoenolpyruvate carboxykinase (EC 4.1.1.32). Similar to many Prokaryotic and Eukaryotic phosphoenolpyruvate carboxykinases including: Mycobacterium tuberculosis Rv0211 SW:PPCK_MYCTU (P96393) fasta scores: E(): 0, 86.1% identity in 605 aa, Chlorobium limicola SW:PPCK_CHLLI (Q08262) fasta scores: E(): 0, 56.1% identity in 592 aa and to Rattus norvegicus SW:PPCC_RAT (P07379) fasta scores: E(): 0, 50.3% identity in 624 aa. Contains Pfam match to entry PF00821 PEPCK, Phosphoenolpyruvate carboxykinase. Contains PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. O06084 No intermediary metabolism and respiration PF00821 O06084 GO:0005737,GO:0006094,GO:0030145,GO:0004613,GO:0005525 4.1.1.32 Rv0211 Rv0211 AL450380.2 Mycobrowser_v4 CDS 3236668 3238794 . - 0 ML2688c ponA1 INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FINAL STAGES), CELL WALL FORMATION. SYNTHESIS OF CROSS-LINKED PEPTIDOGLYCAN FROM THE LIPID INTERMEDIATES. THE ENZYME HAS A PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE N-TERMINAL DOMAIN (FORMATION OF LINEAR GLYCAN STRANDS) AND A PENICILLIN-SENSITIVE TRANSPEPTIDASE C-TERMINAL DOMAIN (CROSS-LINKING OF THE PEPTIDE SUBUNITS). PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE) ML2688c, len: 708 aa. Probable ponA1, bifunctional penicillin-binding protein 1a/1b (EC 2.4.2.-; 3.4.-.-). Similar to Mycobacterium tuberculosis probable penicillin-binding proteins 1a/1b TR:P71707 (EMBL:Z80775) fasta scores: E(): 0, 82.6% in 679 aa, and to Bacillus subtilis penicillin-binding proteins 1a/1b SW:PBPA_BACSU (P39793) fasta scores: E(): 3.6e-28, 27.0% in 688 aa. Contains Pfam match to entry PF00912 Transglycosyl, Transglycosylase. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Q9CCY4 No cell wall and cell processes PF00905,PF00912 Q9CCY4 GO:0008658,GO:0009252,GO:0009274,GO:0008360,GO:0003824 Rv0050 Rv0050 AL450380.2 Mycobrowser_v4 CDS 1220377 1220676 . + 0 ML1053 PE5 PE FAMILY PROTEIN ML1053, len: 99 aa. Member of PE family protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49943 (EMBL:U15180) (99 aa), Fasta scores: E(): 0, 100.0% identity in 99 aa overlap. Also highly similar to the whole or just the N-terminus of many Mycobacterium tuberculosis PE-family proteins e.g. Rv1195 O05297 (111 aa), fasta scores: E(): 5.8e-13 (48.913% identity in 92 aa overlap) and TR:P71664 (EMBL:Z80108) (576 aa), Fasta scores: E(): 3.2e-10, 44.6% identity in 92 aa overlap. Also similar to ML1183c a possible paralogue of M. tuberculosis Rv1195. No PE/PPE Rv1195 Rv1195 AL450380.2 Mycobrowser_v4 CDS 1229651 1230631 . + 0 ML1064 gpgS conserved hypothetical protein ML1064, len: 326 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49955 (EMBL:U15180) (318 aa), Fasta scores: E(): 0, 100.0% identity in 317 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1208 TR:O05309 (EMBL:Z93777) (324 aa), Fasta scores: E(): 0, 79.8% identity in 327 aa overlap. Q9CCA9 No conserved hypotheticals, intermediary metabolism and respiration PF00535 Q9CCA9 Rv1208 Rv1208 AL450380.2 Mycobrowser_v4 CDS 1575497 1575688 . + 0 ML1321 pup conserved hypothetical protein ML1321, len: 63 aa. Conserved hypothetical protein. Highly similar to many proteins of undefined function found upstream of bacterial proteasome beta subunits including: Mycobacterium smegmatis TR:O30517 (EMBL:AF009645) (64 aa), Fasta scores: E(): 6.2e-18, 82.8% identity in 64 aa overlap, Rhodococcus sp. TR:Q53082 (EMBL:U26422) (64 aa), Fasta scores: E(): 6.7e-17, 82.8% identity in 64 aa overlap and Mycobacterium tuberculosis Rv2111c TR:O33246 (EMBL:Z97559) (64 aa), Fasta scores: E(): 7.9e-19, 87.5% identity in 64 aa overlap. Note the high number of the amino acids Glu, Asp and Gly. Contains a possible coiled-coil region. Q9ZBE0 No conserved hypotheticals, intermediary metabolism and respiration PF05639 Q9ZBE0 Rv2111c Rv2111c AL450380.2 Mycobrowser_v4 CDS 1573921 1575465 . + 0 ML1320 dop conserved hypothetical protein ML1320, len: 514 aa. Conserved hypothetical protein. Highly similar to many proteins of undefined function including: Rhodococcus sp. TR:Q53081 (EMBL:U26422) (499 aa), Fasta scores: E(): 0, 83.5% identity in 502 aa overlap and Mycobacterium tuberculosis Rv2112c TR:O33247 (EMBL:Z97559) (554 aa), Fasta scores: E(): 0, 95.4% identity in 504 aa overlap. Q7AQ69 No conserved hypotheticals, intermediary metabolism and respiration PF03136,PF03316 Q7AQ69 Rv2112c Rv2112c AL450380.2 Mycobrowser_v4 CDS 503218 504402 . + 0 ML0405 espA Conserved hypothetical protein ML0405, len: 394 aa. Conserved hypothetical protein, highly similar to Rv3616c|O06267|AL123456 conserved hypothetical protein from M. tuberculosis (392 aa), Fasta scores: E(): 0, (62.7% identity in 394 aa overlap) and similar to Rv3864|P96213|AL123456 hypothetical protein from M. tuberculosis (402 aa), Fasta scores: E(): 2.1e-15, (31.0% identity in 410 aa overlap). Previously sequenced as Q49722|U00015 (394 aa), Fasta scores: E(): 0, (100.0% identity in 394 aa overlap). Q49722 No conserved hypotheticals, cell wall and cell processes Q49722 Rv3616c Rv3616c AL450380.2 Mycobrowser_v4 CDS 58020 59558 . - 0 ML0047c eccD1 ESX CONSERVED COMPONENT ECCD1. PROBABLE TRANSMEMBRANE PROTEIN. ML0047c, len: 512 aa. esx conserved component, probable transmembrane protein, highly similar to M. tuberculosis probable membrane proteins e.g. Rv3877|O69741|AL123456 transmembrane protein (511 aa), Fasta scores: 74.0% identity in 512 aa overlap. Similarity is weaker to Rv1795|O53944|AL123456 probable membrane protein (503 aa), Fasta scores: E(): 2.1e-13, (22.7% identity in 519 aa overlap) and Rv0290|O86362|AL123456 hydrophobic protein (472 aa), Fasta scores: E(): 2.4e-11, (26.6% identity in 512 aa overlap). Also similar to ML1539 and ML2529 from M. leprae. Previously sequenced as O33081|Y14967 (480 aa), Fasta scores: E(): 0, (100.0% identity in 480 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDD9 No cell wall and cell processes PF04600 Q9CDD9 Rv3877 Rv3877 AL450380.2 Mycobrowser_v4 CDS 3011718 3013175 . - 0 ML2529c eccD3 ESX CONSERVED COMPONENT ECCD3. PROBABLE TRANSMEMBRANE PROTEIN. ML2529c, len: 485 aa. esx conserved component, probable transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0290 TR:O86362 (EMBL:AL021930) fasta scores: 76.4% identity in 471 aa, and to Streptomyces coelicolor putative integral membrane protein SC3C3.21 TR:O86654 (EMBL:AL031231) fasta scores: E(): 1.9e-05, 23.8% identity in 483 aa. Contains multiple possible membrane spanning hydrophobic domains towards the C-terminus. Q9CD35 No cell wall and cell processes PF04600 Q9CD35 Rv0290 Rv0290 AL450380.2 Mycobrowser_v4 CDS 2307461 2308078 . - 0 ML1923B ML1923B hypothetical protein(pseudogene) ML1923B, len:617. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 51993 53396 . + 0 ML0042 eccE1 ESX CONSERVED COMPONENT ECCE1. POSSIBLE MEMBRANE PROTEIN. ML0042, len: 467 aa. Possible conserved membrane protein, highly similar to Rv3882c|O05462|AL123456 conserved membrane protein from M. tuberculosis (462 aa), Fasta scores: E(): 0, (72.1% identity in 462 aa overlap). Shows weak similarity to O05459|AL123456 hypothetical protein from M.tuberculosis (537 aa), Fasta scores: E(): 3.1e-09, (28.0% identity in 382 aa overlap). Also shows weak similarity to ML1537. Previously sequenced as O33077|Y14967 (467 aa), Fasta scores: E(): 0, (100.0% identity in 467 aa overlap). Contains hydrophobic, possible membrane-spanning regions near the N-terminus. Q7AQP3 No cell wall and cell processes Q7AQP3 Rv3882c Rv3882c AL450380.2 Mycobrowser_v4 CDS 1376133 1377067 . + 0 ML1178B ML1178B hypothetical protein(pseudogene) ML1178B, len:934. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-32 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 504460 504780 . + 0 ML0406 espC ESX-1 SECRETION-ASSOCIATED PROTEIN ESPC ML0406, len: 106 aa. ESX-1 secretion-associated protein, highly similar to Rv3615c|O06268|AL123456 ESX-1 secretion-associated protein from M. tuberculosis (103 aa), Fasta scores: E(): 4.1e-19, (60.9% identity in 92 aa overlap) and similar to Rv3865|P96212|AL123456, protein from M. tuberculosis (103 aa), Fasta scores: E(): 0.00022, (31.1% identity in 103 aa overlap). Previously sequenced as Q49723|U00015 (106 aa), Fasta scores: (100.0% identity in 106 aa overlap). Q49723 No cell wall and cell processes Q49723 Rv3615c Rv3615c AL450380.2 Mycobrowser_v4 CDS 70584 71093 . - 0 ML0056c espH ESX-1 SECRETION-ASSOCIATED PROTEIN ESPH ML0056c, len: 169 aa. ESX-1 secretion-associated protein, similar to several proteins in M. tuberculosis e.g. Rv3867|O06269|AL123456 ESX-1 secretion-associated protein (184 aa), Fasta scores: E(): 1.1e-12, (38.4% identity in 172 aa overlap); and Rv3614c|O69732|AL123456 protein (183 aa), Fasta scores: E(): 1e-20, (48.2% identity in 166 aa overlap). Also similar to ML0407 from M. leprae. Previously sequenced as Q49730|U00015 (216 aa), Fasta scores: E(): 1.7e-13, (40.2% identity in 169 aa overlap.) Q9CDD6 No cell wall and cell processes Q9CDD6 Rv3867 Rv3867 AL450380.2 Mycobrowser_v4 CDS 59555 61315 . - 0 ML0048c espI ESX-1 SECRETION-ASSOCIATED PROTEIN ESPI. CONSERVED PROLINE AND ALANINE RICH PROTEIN. ML0048c, len: 586 aa. ESX-1 secretion-associated protein, conserved pro-, ala-rich protein. Similar to several proteins from M. tuberculosis, some of which also contain proline-rich regions e.g. Rv3876|O69740|AL123456 pro-, ala-rich protein (666 aa), Fasta scores: (50.7% identity in 672 aa overlap); and Rv0530|O06396|AL123456 hypothetical protein (405 aa), Fasta scores: E(): 1.3e-19, (30.5% identity in 417 aa overlap). Similar to the C-terminal half of O86637|AL031231 hypothetical protein SC3C3.03C from Streptomyces coelicolor (1083 aa), Fasta scores: E(): 5.9e-27, (31.6% identity in 580 aa overlap), which contains Pro-Gln repeats. C-terminal half is similar to that of ML0798. Previously sequenced as O33082|Y14967 (478 aa), Fasta scores: (100.0% identity in 478 aa overlap). Q9CDD8 No cell wall and cell processes Q9CDD8 Rv3876 Rv3876 AL450380.2 Mycobrowser_v4 CDS 93497 93592 . - 0 ML0072A ML0072A hypothetical protein(pseudogene) ML0072A, len:95. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 6.00E-11 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2219124 2219201 . - 0 ML1830D ML1830D sigL; RNA polymerase sigma-70 factor, ECF subfamily(pseudogene) ML1830D, len:77. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2282072 2282221 . + 0 ML1897A ML1897A hypothetical protein(pseudogene) ML1897A, len:149. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2288848 2289321 . + 0 ML1903A ML1903A hypothetical protein(pseudogene) ML1903A, len:473. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-08 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2289455 2290228 . + 0 ML1903B ML1903B probable sigma-70 factor, ECF subfamily(pseudogene) ML1903B, len:773. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-27 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2300442 2300600 . - 0 ML1916A ML1916A hypothetical protein(pseudogene) ML1916A, len:158. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-08 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2306879 2307403 . - 0 ML1923A ML1923A hypothetical protein(pseudogene) ML1923A, len:524. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2562593 2563744 . + 0 ML2157C ML2157C hypothetical protein(pseudogene) ML2157C, len:1151. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-13 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2567654 2568142 . - 0 ML2157D ML2157D hypothetical protein(pseudogene) ML2157D, len:488. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-11 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2582749 2582871 . - 0 ML2171A ML2171A hypothetical protein(pseudogene) ML2171A, len:122. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-09 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2613262 2613357 . + 0 ML2199A ML2199A hypothetical protein(pseudogene) ML2199A, len:95. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-11 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2634278 2634409 . - 0 ML2215A ML2215A hypothetical protein(pseudogene) ML2215A, len:131. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2642486 2642860 . + 0 ML2225A ML2225A hypothetical protein(pseudogene) ML2225A, len:374. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2677099 2677260 . + 0 ML2253A ML2253A hypothetical protein(pseudogene) ML2253A, len:161. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-23 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2718274 2718600 . - 0 ML2293A ML2293A hypothetical protein(pseudogene) ML2293A, len:326. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-08 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2726694 2726795 . + 0 ML2301A ML2301A hypothetical protein(pseudogene) ML2301A, len:101. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.002 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2740581 2740760 . - 0 ML2312A ML2312A hypothetical protein(pseudogene) ML2312A, len:179. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-09 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2785498 2785699 . + 0 ML2344A ML2344A ligC; putative DNA ligase(pseudogene) ML2344A, len:201. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-17 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2831491 2831851 . - 0 ML2364A ML2364A hypothetical protein(pseudogene) ML2364A, len:360. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-26 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2831918 2832775 . - 0 ML2364B ML2364B hypothetical protein(pseudogene) ML2364B, len:857. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-68 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2832900 2833503 . + 0 ML2364C ML2364C hypothetical protein(pseudogene) ML2364C, len:603. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-39 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2846233 2846694 . + 0 ML2376A ML2376A PPE family protein(pseudogene) ML2376A, len:461. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 5.00E-11 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2870134 2870534 . + 0 ML2398A ML2398A 3-ketoacyl-CoA thiolase(pseudogene) ML2398A, len:400. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 7.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2892403 2892695 . + 0 ML2417A ML2417A hypothetical protein(pseudogene) ML2417A, len:292. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-12 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2899447 2899545 . + 0 ML2423A ML2423A hypothetical protein(pseudogene) ML2423A, len:98. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.90E-02 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2837761 2839133 . ML2369A ML2369A hypothetical protein(pseudogene) ML2369A, len:1372. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-34 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2899598 2899834 . + 0 ML2423B ML2423B hypothetical protein(pseudogene) ML2423B, len:236. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2942429 2942992 . + 0 ML2468A ML2468A hypothetical protein(pseudogene) ML2468A, len:563. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2943224 2943508 . + 0 ML2468B ML2468B hypothetical protein(pseudogene) ML2468B, len:284. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-30 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2987612 2987857 . - 0 ML2506A ML2506A hypothetical protein(pseudogene) ML2506A, len:245. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-18 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3001122 3001256 . - 0 ML2518A ML2518A hypothetical protein(pseudogene) ML2518A, len:134. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3006465 3006773 . - 0 ML2524A ML2524A hypothetical protein(pseudogene) ML2524A, len:308. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-06 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3006905 3007521 . + 0 ML2524B ML2524B cob(II)yrinic acid a,c-diamide reductase(pseudogene) ML2524B, len:616. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-58 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3009187 3009255 . - 0 ML2526A ML2526A probable trans-aconitate methyltransferase(pseudogene) ML2526A, len:68. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.006 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3028425 3028858 . - 0 ML2541A ML2541A hypothetical protein(pseudogene) ML2541A, len:433. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 9.00E-29 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3053961 3054491 . - 0 ML2561A ML2561A hypothetical protein(pseudogene) ML2561A, len:530. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-26 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3071597 3071932 . - 0 ML2572A ML2572A ilvB_2; acetolactate synthase large subunit(pseudogene) ML2572A, len:335. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-17 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3072508 3072636 . - 0 ML2572B ML2572B hypothetical protein(pseudogene) ML2572B, len:128. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-10 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3111028 3111171 . - 0 ML2606A ML2606A hypothetical protein(pseudogene) ML2606A, len:143. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-19 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3111488 3111742 . + 0 ML2606B ML2606B probable O-methyltransferase(pseudogene) ML2606B, len:254. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-05 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3133705 3133845 . + 0 ML2622A ML2622A hypothetical protein(pseudogene) ML2622A, len:140. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 4.00E-08 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3138159 3138676 . + 0 ML2625A ML2625A hypothetical protein(pseudogene) ML2625A, len:517. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 7.00E-04 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3141821 3141976 . + 0 ML2627A ML2627A hypothetical protein(pseudogene) ML2627A, len:155. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 8.00E-11 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3142171 3142352 . + 0 ML2627B ML2627B hypothetical protein(pseudogene) ML2627B, len:181. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-07 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3145121 3145198 . - 0 ML2629A ML2629A hypothetical protein(pseudogene) ML2629A, len:77. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 0.006 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3156626 3157309 . - 0 ML2638A ML2638A hypothetical protein(pseudogene) ML2638A, len:683. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-21 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3161876 3162501 . - 0 ML2642A ML2642A hypothetical protein(pseudogene) ML2642A, len:625. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 2.00E-18 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 3193644 3193703 . + 0 ML2665A ML2665A hypothetical protein(pseudogene) ML2665A, len:59. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-03 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 1745175 1745290 . + 0 ML1450D ML1450D mmpL4_4; probable conserved transmembrane transport protein(pseudogene) ML1450D (ML1450C), len:406. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 3.00E-28 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 2218579 2218980 . - 0 ML1830E ML1830E hypothetical protein(pseudogene) ML1830C, len:401. Possible pseudogene, E-value obtained after tblastn of a functional mycobacterial protein against a database of intergenic Mleprae sequences = 1.00E-09 (See Gomez-Valero et al., 2007) Yes unknown AL450380.2 Mycobrowser_v4 CDS 977786 978181 . - 0 ML0824c zur PROBABLE ZINC UPTAKE REGULATION PROTEIN ZUR ML0824c, len: 131 aa. Probable zur, zinc uptake regulation protein. Similar to Rv2359|MTCY27.21c|O05839|Z95208 Mycobacterium tuberculosis zur, zinc uptake regulation protein (130 aa), fasta scores: E(): 0, (86.9% identity in 130 aa), and to FUR_ECOLI|P06975 Escherichia coli ferric uptake regulation protein fur (148 aa), fasta scores: E(): 2.1e-13, 37.2% identity in 129 aa. Belongs to the fur/zur family. Note that previously known as furB. Q9CCG6 No regulatory proteins PF01475 Q9CCG6 GO:0003700,GO:0006355 Rv2359 Rv2359 AL450380.2 Mycobrowser_v4 CDS 3249924 3250679 . + 0 ML2698 mutT4 conserved hypothetical protein ML2698, len: 251 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 27.1 kda protein Rv3908 TR:O05437 (EMBL:Z94121) fasta scores: E(): 0, 78.6% in 248 aa. Contains Pfam match to entry PF00293 mutT, Bacterial mutT protein. Contains PS00893 mutT domain signature. Q7APR7 No conserved hypotheticals, information pathways PF00293 Q7APR7 GO:0016787 Rv3908 Rv3908 AL450380.2 Mycobrowser_v4 CDS 1676667 1677056 . + 0 ML1396 rplT Probable 50S ribosomal protein L20 RplT ML1396, len: 129 aa. Probable rplT, 50S ribosomal protein L20. Highly similar to many 50s ribosomal L20 proteins, including: Escherichia coli SW:RL20_ECOLI (P02421) (117 aa), Fasta scores: E(): 1.9e-23, 57.8% identity in 116 aa overlap and Mycobacterium tuberculosis Rv1643 SW:RL20_MYCTU (P94977) (129 aa), Fasta scores: E(): 0, 90.7% identity in 129 aa overlap. Contains Pfam match to entry PF00453 Ribosomal_L20, Ribosomal protein L20. Contains PS00937 Ribosomal protein L20 signature. Q9CC20 No information pathways PF00453 Q9CC20 GO:0000027,GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv1643 Rv1643 AL450380.2 Mycobrowser_v4 CDS 1677111 1677890 . + 0 ML1397 tsnR Possible 23S rRNA methyltransferase TsnR ML1397, len: 259 aa. Possible tsnR, 23S rRNA methyltransferase (EC 2.1.1.-). Similar to several proposed rRNA methylases (SpoU family) e.g. Mycobacterium tuberculosis Rv1644 TR:P94978 (EMBL:Z85982) (260 aa), Fasta scores: E(): 0, 72.8% identity in 257 aa overlap and Escherichia coli SW:TRMH_ECOLI (P19396) (1436 aa), BlastP Expect 7.5. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family. Q9CC19 No information pathways PF00588,PF08032 Q9CC19 GO:0008173,GO:0006396,GO:0003723 Rv1644 Rv1644 AL450380.2 Mycobrowser_v4 CDS 2724186 2724986 . - 0 ML2299c ML2299c conserved hypothetical protein ML2299c, len: 266 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv3672c or MTV025.020C TR:O69640 (EMBL:AL022121) (273 aa) fasta scores: E(): 0, 76.4% identity in 267 aa. Similar to hypothetical proteins e.g. Streptomyces coelicolor hypothetical protein SCH17.02C TR:Q9XA45 (EMBL:AL079353) (247 aa) fasta scores: E(): 6.7e-26, 43.5% identity in 232 aa. Contains PS01293 Uncharacterized protein family UPF0035 signature. Q9CB94 No conserved hypotheticals PF00293 Q9CB94 GO:0000287,GO:0030145,GO:0009132,GO:0016818 Rv3672c Rv3672c AL450380.2 Mycobrowser_v4 CDS 2617856 2618977 . + 0 ML2203 ML2203 conserved hypothetical protein ML2203, len: 373 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 39.4 kda protein Rv0811c TR:O53825 (EMBL:AL022004) fasta scores: E(): 0, 77.4% id in 367 aa, and to Corynebacterium ammoniagenes orf4 TR:Q9RHX9 (EMBL:AB003158) fasta scores: E(): 1.5e-13, 40.5% identity in 373 aa. Q9CBC4 No conserved hypotheticals PF01571 Q9CBC4 GO:0005737,GO:0006546,GO:0004047 Rv0811c Rv0811c AL450380.2 Mycobrowser_v4 CDS 234932 235534 . + 0 ML0169 ML0169 Conserved hypothetical protein ML0169, len: 200 aa. Conserved hypothetical protein, highly similar to Rv0966c|Y966_MYCTU|P71544 hypothetical protein from M. tuberculosis (200 aa), Fasta scores: E(): 0, (79.5% identity in 200 aa overlap). Also similar to CAB88834|AL353832 hypothetical protein SCE6.30C from Streptomyces coelicolor (277 aa), Fasta scores: E(): 3.3e-20, (41.0% identity in 205 aa overlap). Previously sequenced as Q9Z5H1|AL035500 (200 aa), Fasta scores: E(): 0, (100.0% identity in 200 aa overlap). Q7AQN2 No conserved hypotheticals PF08044 Q7AQN2 Rv0966c Rv0966c AL450380.2 Mycobrowser_v4 CDS 2878357 2878692 . - 0 ML2407c ML2407c POSSIBLE CONSERVED MEMBRANE PROTEIN ML2407c, len: 111 aa. Possible conserved membrane protein. Similar to Mycobacterium tuberculosis membrane protein Rv0531 or mtcy25d10.10 TR:O06397 (EMBL:Z95558) (105 aa) fasta scores: E(): 2.4e-24, 73.1% identity in 93 aa. Contains a possible membrane spanning hydrophobic domain. Q9CB63 No cell wall and cell processes Q9CB63 Rv0531 Rv0531 AL450380.2 Mycobrowser_v4 CDS 158056 159252 . + 0 ML0117 ML0117 Possible aminotransferase ML0117, len: 398 aa. Possible aminotransferase (EC 2.6.1.-), highly similar to Rv3778c|P72044|AL123456 possible aminotransferase from M. tuberculosis (398 aa), Fasta scores: E(): 0, (83.4% identity in 398 aa overlap); and similar to many bacterial putative aminotransferases. Also similar to ML0596 and to the C-terminal half of ML0842 from M. leprae. Q9CD97 No intermediary metabolism and respiration PF00266 Q9CD97 GO:0008152,GO:0030170,GO:0003824 Rv3778c Rv3778c AL450380.2 Mycobrowser_v4 CDS 159249 160259 . - 0 ML0118c ML0118c Probable oxidireductase ML0118c, len: 336 aa. Probable oxidoreductase (EC 1.-.-.-), highly similar to Rv3777|P72043 putative oxidireductase from M. tuberculosis (328 aa). Similar to many oxidoreductases from both bacteria and higher organisms e.g. QOR_MOUSE|P47199 cryZ, quinone oxidoreductase from Mus musculus (331 aa), Fasta scores: E(): 5.5e-21, (31.0% identity in 306 aa overlap). And similar to domains of polyketide synthases ML0135, ML0139, ML1229 and ML2355 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Q9CD96 No intermediary metabolism and respiration PF00107,PF08240 Q9CD96 GO:0016491,GO:0008270,GO:0055114 Rv3777 Rv3777 AL450380.2 Mycobrowser_v4 CDS 95132 95947 . + 0 ML0074 glpQ1 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) ML0074, len: 271 aa. Probable glpQ1, glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46), highly similar to Rv3842c|P96236|AL123456 glpQ1, glycerophosphoryl diester phosphodiesterase from M. tuberculosis (274 aa), Fasta scores: E(): 0, (88.8% identity in 269 aa overlap). Also similar to GLPQ_BACSU|P37965 glpQ, glycerophosphoryl diester phosphodiesterase from Bacillus subtilis (293 aa), Fasta scores: E(): 2.3e-20, (32.0% identity in 250 aa overlap). Q9CDC5 No intermediary metabolism and respiration PF03009 Q9CDC5 GO:0008889,GO:0006629,GO:0006071 3.1.4.46 Rv3842c Rv3842c AL450380.2 Mycobrowser_v4 CDS 170662 171351 . + 0 ML0127 ML0127 Possible methyltransferase ML0127, len: 229 aa. Possible methyltransferase (EC 2.1.1.-), highly similar to Rv2959c|Q50457|AL123456 Possible methyltransferase from M. tuberculosis (245 aa), Fasta scores: E(): 0, (76.1% identity in 226 aa overlap). Shows weak similarity to O85726|AF073896 cmcI, cephalosporin hydroxylase component of 7 alpha-cephem-methoxylase from Streptomyces clavuligerus (236 aa), Fasta scores: E(): 0.0001, (27.6% identity in 163 aa overlap ); and to other hypothetical proteins. Q9CD89 No intermediary metabolism and respiration PF04989 Q9CD89 GO:0008168,GO:0008610 2.1.1.- Rv2959c Rv2959c AL450380.2 Mycobrowser_v4 CDS 2081 3280 . + 0 ML0002 dnaN DNA polymerase III ia a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonucleases activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA [Catalytic activity: N deoxynucleoside triphosphate = N diphosphate + {DNA}N]. Probable DNA polymerase III, [beta] subunit DnaN ML0002, len: 399 aa. Probable dnaN, DNA polymerase III (beta chain) (EC 2.7.7.7) (see citations below). Equivalent to other Mycobacterial DNA POLYMERASES III BETA CHAIN e.g. Rv0002|DP3B_MYCTU|Q50790 from M. tuberculosis (402 aa), Fasta scores: E(): 0, (81.9% identity in 403 aa overlap); and DP3B_MYCSM|P52851 from M. smegmatis (397 aa), Fasta scores: E(): 0, (77.3% identity in 397 aa overlap). Previously sequenced as DP3B_MYCLE|P46387 (399 aa), Fasta scores: E(): 0, (100.0% identity in 399 aa overlap). Contains Pfam match to entry PF00712 DNA_pol3_beta, DNA polymerase III beta subunit. P46387 No information pathways PF00712,PF02767,PF02768 P46387 GO:0003677,GO:0006260,GO:0003887,GO:0005737,GO:0008408 2.7.7.7 Rv0002 Rv0002 AL450380.2 Mycobrowser_v4 CDS 3281 4438 . + 0 ML0003 recF Probable DNA replication and repair protein RecF ML0003, len: 385 aa. Probable recF, DNA replication and repair protein (see citations below), highly similar to other Mycobacterial DNA replication and repair proteins e.g. Rv0003|RECF_MYCTU|Q59586 from M. tuberculosis (385 aa), Fasta scores: E(): 0, (76.4% identity in 385 aa overlap); and RECF_MYCSM|P50916 from M. smegmatis (384 aa), Fasta scores: E(): 0, (70.0% identity in 383 aa overlap). Previously sequenced as RECF_MYCLE|P46391 (385 aa), Fasta scores: E(): 0, (99.5% identity in 385 aa overlap). Contains 2 Pfam matches to entry PF00470 RecF, RecF protein. Contains PS00617 RecF protein signature 1. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00618 RecF protein signature 2. Belongs to the RecF family. P46391 No information pathways PF02463 P46391 GO:0006281,GO:0006260,GO:0009432,GO:0005694,GO:0005737,GO:0003697,GO:0005524 Rv0003 Rv0003 AL450380.2 Mycobrowser_v4 CDS 16566 16979 . - 0 ML0012c ML0012c Probable conserved membrane protein ML0012c, len: 137 aa. Probable conserved membrane protein, similar to Rv0010c|Y010_MYCTU|P71580 probable conserved membrane protein from M. tuberculosis (141 aa), Fasta scores: E(): 0, (71.5% identity in 137 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDE8 No cell wall and cell processes Q9CDE8 Rv0010c Rv0010c AL450380.2 Mycobrowser_v4 CDS 17134 17415 . - 0 ML0013c ML0013c Probable conserved transmembrane protein ML0013c, len: 93 aa. Probable conserved transmembrane protein, similar to Rv0011c|Y011_MYCTU|P71581 probable conserved transmembrane protein from M. tuberculosis (93 aa), Fasta scores: E(): 0, (89.2% identity in 93 aa overlap); also similar to Q8NU99 Cgl0040 hypothetical membrane protein from Corynebacterium glutamicum (90 aa), E(): 0, (40.0% identity in 95 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDE7 No cell wall and cell processes PF06781 Q9CDE7 GO:0005886,GO:0016021 Rv0011c Rv0011c AL450380.2 Mycobrowser_v4 CDS 100648 102000 . - 0 ML0081c ML0081c Probable conserved membrane protein ML0081c, len: 450 aa. Probable conserved membrane protein, highly similar to Rv3835c|P96243|AL123456 conserved membrane protein from M. tuberculosis (449 aa), Fasta scores: E(): 0, (69.4% identity in 457 aa overlap). Contains hydrophobic, possible membrane-spanning region near the N-terminus. Q9CDC2 No cell wall and cell processes Q9CDC2 Rv3835 Rv3835 AL450380.2 Mycobrowser_v4 CDS 20879 22192 . - 0 ML0017c pknA Involved in signal transduction (via phosphorylation). Thought to regulate morphological changes asociated with cell division/differentiation process. Phosphorylates at serine and threonine residues [catalytic activity: ATP + A Protein = ADP + A Phosphoprotein]. Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) ML0017c, len: 437 aa. Probable pknA, transmembrane serine/threonine-protein kinase (EC 2.7.1.-), possibly magnesium/manganese dependent (see citations below), highly similar to Rv0015c|PKNA_MYCTU|P71585 pknA, serine/threonine protein kinase from M. tuberculosis (431 aa), Fasta scores: E(): 0, (81.0% identity in 431 aa overlap) and some similarity to Q9ZFS8|AF094711 pksC, serine/threonine protein kinase from Streptomyces coelicolor (556 aa), Fasta scores: E(): 2.1e-29, (39.9% identity in 346 aa overlap). Also similar to ML0016 and ML0897 and to part of ML0304 from M. leprae. Previously sequenced as PKNA_MYCLE|P54743 (437 aa), Fasta scores: E(): 0, (84.6% identity in 448 aa overlap). Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature. P54743 No regulatory proteins PF00069 P54743 GO:0006468,GO:0004674,GO:0005524 2.7.11.1 Rv0015c Rv0015c AL450380.2 Mycobrowser_v4 CDS 26584 27051 . - 0 ML0021c ML0021c Conserved hypothetical protein ML0021c, len: 155 aa. Conserved hypothetical protein, highly similar to Rv0019c|P71589 hypothetical protein from M. tuberculosis (155 aa), fasta scores: E(): 1.8e-59, (90.968% identity in 155 aa overlap); and similar to Q9XA20|AL079308 hypothetical protein SCH69.14 from Streptomyces coelicolor (172 aa), Fasta scores: E(): 2e-21, (44.4% identity in 171 aa overlap). Similar at the C-terminus to ML2076. Previously sequenced as Q50189|Z70722 (155 aa), Fasta scores: E(): 0, (100.0% identity in 155 aa overlap). Contains Pfam match to entry PF00498 FHA, FHA domain. Q7AQP5 No conserved hypotheticals, regulatory proteins PF00498 Q7AQP5 Rv0019c Rv0019c AL450380.2 Mycobrowser_v4 CDS 27173 28639 . - 0 ML0022c ML0022c Conserved hypothetical protein ML0022c, len: 488 aa. Conserved hypothetical protein (see citations below), highly similar to Rv0020c|P71590|AL123456 hypothetical protein from M. tuberculosis (527 aa), Fasta scores: E(): 0, (71.9% identity in 531 aa overlap); and some similarity at the C-terminus with Q8NU92 Hypothetical protein Cgl0047 from Corynebacterium glutamicum (Brevibacterium flavum) (288 aa), Fasta scores: E(): 0, (55.1% identity in 127 aa overlap). Also similar at the C-terminus to ML2076. Previously sequenced as Q50190|Z70722 (463 aa), Fasta scores: E(): 0, (100.0% identity in 463 aa overlap). Contains Pfam match to entry PF00498 FHA, FHA domain. Q9CDE4 No conserved hypotheticals, regulatory proteins PF00498 Q9CDE4 Rv0020c Rv0020c AL450380.2 Mycobrowser_v4 CDS 35287 36123 . - 0 ML0031c ML0031c Probable secreted proline rich protein (proline rich 28 kda antigen) ML0031c, len: 278 aa. Probable secreted proline rich protein (see citations below), similar to Rv0040c|PR28_MYCTU|P71697 secreted proline rich 28 kDa antigen mtc28 from M. tuberculosis (311 aa), Fasta scores: E(): 0, (65.1% identity in 258 aa overlap). Previously sequenced as O33075|Y14967 (278 aa), Fasta scores: E(): 0, (100.0% identity in 278 aa overlap). C-terminal half is similar to a region of ML0246. Contains a probable N-terminal signal sequence. O33075 No cell wall and cell processes PF10738 O33075 Rv0040c Rv0040c AL450380.2 Mycobrowser_v4 CDS 381423 381647 . - 0 ML0298c thiS Possible protein ThiS ML0298c, len: 74 aa. Possible thiS protein, highly similar to Rv0416|P96262|AL123456 Possible thiS protein from M. tuberculosis (68 aa), Fasta scores: E(): 5.9e-17, (71.6% identity in 74 aa overlap). Shows some similarity to other bacterial thiS proteins e.g. THIS_ECOLI|O32583 thiS, hypothetical protein from Escherichia coli (66 aa), Fasta scores: E(): 0.41, (32.0% identity in 50 aa overlap). Previously sequenced as Q9ZBL3|AL035159 (74 aa), Fasta scores: E(): 1.2e-28, (100.0% identity in 74 aa overlap). Q7AQK0 No intermediary metabolism and respiration Q7AQK0 Rv0416 Rv0416 AL450380.2 Mycobrowser_v4 CDS 61720 62022 . - 0 ML0050c esxB Possible 10 KDA culture filtrate antigen homolog EsxB (lhp) (cfp10) ML0050c, len: 100 aa. Possible esxB, 10 KDA culture filtrate antigen homolog (see citations below). Similar to Rv3874|O69739|AF004671 esxB, culture filtrate protein 10 kDa CFP-10 from M. tuberculosis (100 aa), Fasta scores: E(): 1.8e-10, (40.0% identity in 100 aa overlap). Also shows weak similarity to others M. tuberculosis proteins e.g. Rv1197|O05299|AL123456 hypothetical protein (98 aa), Fasta scores: E(): 0.061, (21.9% identity in 96 aa overlap), and Rv1038c|P96363|AL123456 hypothetical protein (98 aa), Fasta scores: E(): 0.084, (21.9% identity in 96 aa overlap). These and others form a protein family typically found downstream of a member of the ESAT6 family. Previously sequenced as O33084|Y14967 (100 aa), Fasta scores: E(): 0, (100.0% identity in 100 aa overlap). Belongs to the ESAT6 family. O33084 No cell wall and cell processes O33084 Rv3874 Rv3874 AL450380.2 Mycobrowser_v4 CDS 88246 88719 . - 0 ML0066c rraA Probable regulator of RNase E activity A RraA ML0066c, len: 157 aa. Probable rraA, regulator of RNase E activity A, highly similar to Rv3853|P96224|AL123456 rraA, regulator of RNase E from M. tuberculosis (157 aa), Fasta scores: E(): 0, (87.1% identity in 155 aa overlap). Similar to many others e.g. RRAA_ECOLI|P32165 rraA, Regulator of ribonuclease activity A from Escherichia coli (161 aa), Fasta scores: E(): 2.4e-20, (45.6% identity in 149 aa overlap). Belongs to the rraA family. Previously known as menG. Q9CDD2 No regulatory proteins PF03737 Q9CDD2 GO:0008428,GO:0051252 Rv3853 Rv3853 AL450380.2 Mycobrowser_v4 CDS 115371 117302 . + 0 ML0093 glfT Bifunctional UDP-galactofuranosyl transferase GlfT ML0093, len: 643 aa. Probable glfT, bifunctional UDP-galactofuranosyl transferase (EC 2.-.-.-) (see citations below), highly similar to Rv3808c|O53585|AL123456 bifunctional UDP-galactofuranosyl transferase from M. tuberculosis (637 aa), Fasta scores: E(): 0, (85.4% identity in 643 aa overlap). Q9CDB7 No cell wall and cell processes Q9CDB7 Rv3808c Rv3808c AL450380.2 Mycobrowser_v4 CDS 117295 117873 . + 0 ML0094 ML0094 Possible conserved transmembrane protein ML0094, len: 192 aa. Possible conserved transmembrane protein, highly similar to Rv3807c|O53584|AL123456) possible transmembrane protein from M. tuberculosis (165 aa), Fasta scores: E(): 0, (72.8% identity in 151 aa overlap); and similar to CAB89062|AL353872 putative integral membrane protein SC5G8.11 from Streptomyces coelicolor (169 aa), Fasta scores: E(): 1.7e-15, (45.1% identity in 153 aa overlap). Also similar to Q8NLQ8 Membrane-associated phospholipid phosphatase from Corynebacterium glutamicum (168 aa), Fasta scores: E(): 1.6e-27, (51.9% identity in 160 aa overlap). Contains hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF01569 PAP2, PAP2 superfamily. Q9CDB6 No cell wall and cell processes PF01569 Q9CDB6 GO:0016020,GO:0003824 Rv3807c Rv3807c AL450380.2 Mycobrowser_v4 CDS 122310 123215 . + 0 ML0098 fbpD Involved in cell wall mycoloylation. Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. Secreted MPB51/MPT51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) ML0098, len: 301 aa. Probable fbpD (alternate gene names: mpt51, mpb51, fbpC1), secreted MPB51/MPT51 antigen protein (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below), similar to Rv3803c|A85C_MYCTU|P17944 fbpD, secreted MPB51/MPT51 antigen protein from M. tuberculosis fbpC (340 aa), Fasta scores: E(): 0, (40.7% identity in 305 aa overlap). Also similar to the B- and C- proteins of the mycobacterial antigen 85 complexes. Similar to N-terminal region of CSP1_CORGL|Q01377 PS1 protein precursor from Corynebacterium glutamicum csp1 (657 aa), Fasta scores: E(): 1.4e-14, (31.5% identity in 248 aa overlap). Previously sequenced as MPB51 precursor, Q48923|D26486 (299 aa), Fasta scores: E(): 0, (77.5% identity in 302 aa overlap). Also similar to ML0097, ML2028 and ML2655 from M. leprae. Contains probable N-terminal signal sequence. Contains Pfam match to entry PF00756 Esterase, Putative esterase. Q05868 No lipid metabolism PF00756 Q05868 GO:0005576,GO:0008415 Rv3803c Rv3803c AL450380.2 Mycobrowser_v4 CDS 147460 149358 . - 0 ML0107c ML0107c Probable conserved transmembrane protein ML0107c, len: 632 aa. Probable conserved transmembrane protein, highly similar to Rv3792|P72058|AL123456 transmembrane protein from M. tuberculosis (643 aa), Fasta scores: E(): 0, (77.5% identity in 631 aa overlap); and to the C-terminal half of O05765|U46844 membrane protein from Mycobacterium smegmatis ORF3 (603 aa), Fasta scores: E(): 0, (67.8% identity in 267 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDA6 No cell wall and cell processes Q9CDA6 GO:0016021,GO:0005886,GO:0046677,GO:0016757,GO:0007047 2.4.2.- Rv3792 Rv3792 AL450380.2 Mycobrowser_v4 CDS 154576 155394 . - 0 ML0114c rfbE Probable lipopolysaccharide-transport ATP-binding protein ABC transporter RfbE ML0114c, len: 272 aa. Probable rfbE, polysaccharide-transport ATP-binding protein ABC transporter, involved in O-antigen/lipopolysaccharides (LPS) transport (see first citation below), equivalent to Rv3781|P72047|AL123456 probable rfbE, polysaccharide-transport ATP-binding protein ABC transporter from M. tuberculosis (273 aa), Fasta scores: E(): 0, (91.4% identity in 267 aa overlap). Similar to RFBE_YEREN|Q56903 rfbE, O-antigen export system ATP-binding protein from Yersinia enterocolitica (239 aa), Fasta scores: E(): 0, (46.9% identity in 224 aa overlap); and to other proteins involved in lipopolysaccharide transport. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters). Q9CDA0 No cell wall and cell processes PF00005 Q9CDA0 GO:0016887,GO:0005524 Rv3781 Rv3781 AL450380.2 Mycobrowser_v4 CDS 155965 157929 . - 0 ML0116c ML0116c Probable conserved transmembrane protein ML0116c, len: 654 aa. Probable conserved transmembrane ala-, leu-rich protein, similar to Rv3779|P72045|AL123456 transmembrane protein from M. tuberculosis (666 aa), Fasta scores: E(): 0, (66.5% identity in 666 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CD98 No cell wall and cell processes Q9CD98 Rv3779 Rv3779 AL450380.2 Mycobrowser_v4 CDS 167598 168914 . + 0 ML0125 ML0125 Possible glycosyl transferase ML0125, len: 438 aa. Possible glycosyl transferase (EC 2.4.1.-) (see citation below), highly similar to M. tuberculosis putative glycosyl transferases e.g. Rv2962c|P95130|AL123456 (449 aa), Fasta scores: E(): 0, (77.5% identity in 426 aa overlap); and Rv2958c|P95134|AL123456 (428 aa), Fasta scores: E(): 0, (74.6% identity in 418 aa overlap). Similar to Q9ZGH7|AF079762 desVII, glycosyl transferase from a macrolide antibiotic biosynthesis gene cluster in Streptomyces venezuelae (426 aa), Fasta scores: E(): 1e-09, (30.0% identity in 237 aa overlap). Shows similarity to bacterial and eukaryotic glycosyl transferases. Also similar to ML0128 and shows weaker similarity to ML0985 from M. leprae. Q9CD91 No intermediary metabolism and respiration PF00201 Q9CD91 GO:0016758,GO:0008152 Rv2962c Rv2962c AL450380.2 Mycobrowser_v4 CDS 173170 174426 . - 0 ML0129c ML0129c Conserved hypothetical protein ML0129c, len: 418 aa. Conserved hypothetical protein, highly similar to Rv2953|P95139|AL123456 conserved hypothetical protein from M. tuberculosis (418 aa), Fasta scores: E(): 0, (86.6% identity in 418 aa overlap); and to Rv2449c|O53176|AL123456 conserved hypothetical protein M. tuberculosis (419 aa), Fasta scores: E(): 0, (64.9% identity in 419 aa overlap). Similar to many bacterial hypothetical proteins. Q9CD87 No conserved hypotheticals, lipid metabolism PF03435 Q9CD87 GO:0008610,GO:0055114,GO:0016491,GO:0005488 1.3.1.- Rv2953 Rv2953 AL450380.2 Mycobrowser_v4 CDS 174466 175278 . - 0 ML0130c ML0130c Probable methyltransferase (Methylase) ML0130c, len: 270 aa. Probable methyltransferase (EC 2.1.1.-), highly similar to Rv2952|Q50464|AL123456 probable methyltransferase from M. tuberculosis (270 aa), Fasta scores: E(): 0, (83.7% identity in 270 aa overlap); and similar to Q9RMN9 putative methyltransferase from Mycobacterium smegmatis (274 aa), Fasta scores: E(): 0, (50.6% identity in 257 aa overlap). Similar in part to Q54303|X86780 rapM, methyltransferase involved in rapamycin biosynthesis from Streptomyces hygroscopicus (317 aa), Fasta scores: E(): 5e-14, (38.6% identity in 158 aa overlap). Also similar to ML1881c a possible pseudogene similar to M. tuberculosis Rv2952. Q9CD86 No intermediary metabolism and respiration PF08241 Q9CD86 GO:0008168,GO:0008610 2.1.1.- Rv2952 Rv2952 AL450380.2 Mycobrowser_v4 CDS 177170 179212 . + 0 ML0132 fadD29 Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) ML0132, len: 680 aa. Probable fadD29, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to various mycobacterial enzymes believed to be involved in polyketide or fatty acid synthesis. Highly similar to Rv2950|P95141|AL123456 fadD29, fatty-acid-CoA synthetase from M. tuberculosis (619 aa), Fasta scores: E(): 0, (80.2% identity in 620 aa overlap); and similar to P71495|U75685 acyl-CoA synthase from Mycobacterium bovis BCG (582 aa), Fasta scores: E(): 0, (58.5% identity in 585 aa overlap); and to domains of polyketide synthases e.g. Q50857|U24657 safB, saframycin Mx1 synthetase B from Myxococcus xanthus (1770 aa), Fasta scores: E(): 0, (36.2% identity in 589 aa overlap). Also similar to ML0100, ML0138, ML1234 and ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Q9CD84 No lipid metabolism PF00501 Q9CD84 GO:0008152,GO:0003824 Rv2950c Rv2950c AL450380.2 Mycobrowser_v4 CDS 179256 179888 . + 0 ML0133 ML0133 Conserved hypothetical protein ML0133, len: 210 aa. Conserved hypothetical protein, similar to Rv2949c|O86325|AL123456 conserved hypothetical protein from M. tuberculosis (199 aa), Fasta scores: E(): 0, (62.6% identity in 195 aa overlap). Shows weak similarity to O28875|AE001008 hypothetical protein AF1396 from Archaeoglobus fulgidus (162 aa), Fasta scores: E(): 4.2e-05, (26.6% identity in 154 aa overlap). Contains Pfam match to entry PF01947 DUF98, protein of unknown function. Q9CD83 No conserved hypotheticals, intermediary metabolism and respiration PF01947 Q9CD83 GO:0016829 4.1.3.- Rv2949c Rv2949c AL450380.2 Mycobrowser_v4 CDS 182173 188484 . + 0 ML0135 pks1 Probable polyketide synthase Pks1 ML0135, len: 2103 aa. Probable pks1, polyketide synthase, The N-terminus is highly similar to Rv2947c|P96284|Z83858 pks15, probable polyketide synthase (496 aa), Fasta scores: E(): 0, (90.5% identity in 485 aa overlap); and the remainder is highly similar to Rv2946c|P96285|Z83858 pks1, probable polyketide synthase (1616 aa), Fasta scores: E(): 0, (82.5% identity in 1620 aa overlap). Also similar to many polyketide synthases from M. tuberculosis and other bacteria e.g. AAF71776|AF263912 NysC, nystatin biosynthesis polyketide synthase from Streptomyces noursei (11096 aa), Fasta scores: E(): 0, (50.2% identity in 2161 aa overlap). And similar to ML0101, ML0139, ML1229, ML2353, ML2354, ML2355, ML2356 and ML2357 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q9CD81 No lipid metabolism PF00106,PF00107,PF00109,PF00550,PF00698,PF02801,PF08240,PF08990 Q9CD81 GO:0009058,GO:0048037,GO:0055114,GO:0016491,GO:0031177,GO:0016740,GO:0008270,GO:0000036 Rv2947c,Rv2946c Rv2947c,Rv2946c AL450380.2 Mycobrowser_v4 CDS 194221 200571 . + 0 ML0139 mas Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas ML0139, len: 2116 aa. Probable mas, mycocerosic acid synthase membrane associated, multifunctional enzyme (see citations below), highly similar to many polyketide synthases from M. tuberculosis e.g. Rv2940c|P96291|AL123456) mas, mycocerosic acid synthase (2111 aa), Fasta scores: E(): 0, (88.0% identity in 2119 aa overlap); and to MCAS_MYCBO|Q02251 mas, mycocerosic acid synthase from Mycobacterium bovis (2110 aa), Fasta scores: E(): 0, (85.1% identity in 2122 aa overlap). Also similar to ML0101, ML0135, ML1229, ML2353, ML2354, ML2355, ML2356 and ML2357 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q9CD78 No lipid metabolism PF00107,PF00109,PF00550,PF00698,PF02801,PF08240,PF08659 Q9CD78 GO:0009058,GO:0048037,GO:0055114,GO:0016491,GO:0031177,GO:0016740,GO:0008270,GO:0000036 Rv2940c Rv2940c AL450380.2 Mycobrowser_v4 CDS 189253 191961 . - 0 ML0137c mmpL7 Conserved transmembrane transport protein MmpL7 ML0137c, len: 902 aa. mmpL7, conserved transmembrane transport protein (see citations below), member of RND superfamily, similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942|MML7_MYCTU|P96289, mmpL7, conserved transmembrane transport protein (920 aa), Fasta scores: E(): 0, (68.6% identity in 881 aa overlap). Also similar to ML1231 and ML2378 and the pseudogene ML2375 from M. leprae. Contains hydrophobic, possible membrane-spanning regions. Belongs to the MmpL family. In M. tuberculosis it has been experimentaly shown that FadD28 and MmpL7 are transcriptionally coupled. Q7AQN7 No cell wall and cell processes PF03176 Q7AQN7 GO:0016020 Rv2942 Rv2942 AL450380.2 Mycobrowser_v4 CDS 217160 218161 . - 0 ML0154c ML0154c Conserved hypothetical protein ML0154c, len: 333 aa. Conserved hypothetical protein, highly similar to Rv0950c|P71560|AL123456 conserved hypothetical protein from M. tuberculosis (332 aa), Fasta scores: E(): 0, (71.0% identity in 331 aa overlap). Shows weaker similarity to many bacterial hypothetical proteins which contains a Peptidase family M23/M37 domain. Previously sequenced as Q9Z5H9|AL035500) (343 aa), Fasta scores: E(): 0, (100.0% identity in 333 aa overlap). Contains Pfam match to entry PF01551 Peptidase_M37, Peptidase family M23/M37. Q9CD71 No conserved hypotheticals PF01551 Q9CD71 GO:0006508,GO:0004222 Rv0950c Rv0950c AL450380.2 Mycobrowser_v4 CDS 265213 265815 . + 0 ML0199 ML0199 Conserved hypothetical protein ML0199, len: 200 aa. Conserved hypothetical protein, similar to Rv3647c|O06361|AL123456 hypothetical protein from M. tuberculosis (192 aa), Fasta scores: E(): 0, (80.4% identity in 199 aa overlap). Previously sequenced as O69549|AL023093 (200 aa), Fasta scores: E(): 0, (99.5% identity in 200 aa overlap). Q7AQM4 No conserved hypotheticals Q7AQM4 Rv3647c Rv3647c AL450380.2 Mycobrowser_v4 CDS 456985 457428 . + 0 ML0364 rplM Probable 50S ribosomal protein L13 RplM ML0364, len: 147 aa. Probable rplM, 50S ribosomal protein L13, equivalent to Rv3443c|RL13_MYCTU|O06260 rplM, 50S ribosomal protein L13 from M. tuberculosis (147 aa), Fasta scores: E(): 0, (91.2% identity in 147 aa overlap). Also highly similar to others e.g. Q53874|RL13_STRCO|SC6G4.12 from Streptomyces coelicolor (147 aa). Previuosly sequenced as RL13_MYCLE|P38014 (147 aa), Fasta scores: E(): 0, (99.3% identity in 147 aa overlap). Contains Pfam match to entry PF00572 Ribosomal_L13, Ribosomal protein L13. Contains PS00783 Ribosomal protein L13 signature. Belongs to the L13P family of ribosomal proteins. P38014 No information pathways PF00572 P38014 GO:0003735,GO:0006412,GO:0005840 Rv3443c Rv3443c AL450380.2 Mycobrowser_v4 CDS 214272 216608 . + 0 ML0153 uvrD1 Probable ATP dependent DNA helicase UvrD1 ML0153, len: 778 aa. Probable uvrD1, ATP dependent DNA helicase (EC 3.6.1.-), highly similar to Rv0949|P71561|AL123456 uvrD1, ATP dependent DNA helicase from M. tuberculosis (771 aa), Fasta scores: E(): 0, (81.4% identity in 780 aa overlap). Similar to many DNA helicases e.g. PCRA_BACST|P56255 pcrA, ATP-dependent helicase from Bacillus stearothermophilus (724 aa), Fasta scores: E(): 0, (43.8% identity in 774 aa overlap). Also similar to ML0637 from M. leprae. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the UvrD subfamily of helicases. Note that previously known as uvrD. Q9CD72 No information pathways PF00580 Q9CD72 GO:0004003,GO:0003677,GO:0006281,GO:0005524 3.6.1.- Rv0949 Rv0949 AL450380.2 Mycobrowser_v4 CDS 244225 244770 . + 0 ML0177 moaB Thought to be involved in molybdopterin biosynthesis. Catalyzes the dehydratation of 4A-hydroxytetrahydropterins [Catalytic activity: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4A-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O] Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-A-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) ML0177, len: 181 aa. Possible moaB2, pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), highly similar to Rv0984|O53897|AL123456 moaB2, possible pterin-4-alpha-carbinolamine dehydratase from M. tuberculosis (181 aa), Fasta scores: E(): 0, (92.7% identity in 179 aa overlap). Similar to many others e.g. Q9RKA9 Molybdenum cofactor biosynthesis protein from Streptomyces coelicolor A3(2) (179 aa), Fasta scores: E(): 5e-21, (50.0% identity in 150 aa overlap); and to the C-terminal halves of CNX1_ARATH|Q39054 cnx1, multifunctional two-domain protein involved in molybdenum cofactor biosynthesis from Arabidopsis thaliana (670 aa), Fasta scores: E(): 7.7e-10, (36.4% identity in 187 aa overlap); and MOCB_SYNP|Q56208 moaCB, molybdenum cofactor biosynthesis protein from Synechococcus sp. (strain PCC 7942) (319 aa), Fasta scores: E(): 1.3e-09, (35.9% identity in 142 aa overlap). Previously sequenced as Q9Z5G5|AL035500 (181 aa), Fasta scores: E(): 0, (99.4% identity in 181 aa overlap). Q9Z5G5 No intermediary metabolism and respiration PF00994 Q9Z5G5 GO:0006777 Rv0984 Rv0984 AL450380.2 Mycobrowser_v4 CDS 244787 245251 . - 0 ML0178c mscL Possible large-conductance ion mechanosensitive channel MscL ML0178c, len: 154 aa. Possible mscL, large conductance mechanosensitive ion channel (integral membrane protein) (see citations below), highly similar to Rv0985c|MSCL_MYCTU|O53898 mscL, possible mechanosensitive channel protein from M. tuberculosis (151 aa), Fasta scores: E(): 0, (71.0% identity in 155 aa overlap). Similar to many others e.g. MSCL_ECOLI|P23867 mscL, large-conductance mechanosensitive channel from Escherichia coli (136 aa), Fasta scores: E(): 1.3e-07, (32.1% identity in 134 aa overlap). Previously sequenced as MSCL_MYCLE|Q9Z5G4 (154 aa), Fasta scores: E(): 0, (100.0% identity in 154 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01741 MscL, Large-conductance mechanosensitive channel, MscL. Contains PS01327 Large-conductance mechanosensitive channels mscL family signature. Belongs to the MSCL family. Q9Z5G4 No cell wall and cell processes PF01741 Q9Z5G4 GO:0005216,GO:0006811,GO:0005886,GO:0016021 Rv0985c Rv0985c AL450380.2 Mycobrowser_v4 CDS 257035 258567 . - 0 ML0192c ML0192c Conserved membrane protein ML0192c, len: 510 aa. Conserved membrane protein, highly similar to Rv1002c|O05586|AL123456 conserved membrane protein from M. tuberculosis (503 aa), Fasta scores: E(): 0, (80.4% identity in 510 aa overlap). Also similar to Q9RKD3|AL132674 putative integral membrane protein SCE87.05 from Streptomyces coelicolor (591 aa), Fasta scores: E(): 0, (36.7% identity in 531 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CD61 No cell wall and cell processes PF02366 Q9CD61 GO:0016020,GO:0006493,GO:0000030 Rv1002c Rv1002c AL450380.2 Mycobrowser_v4 CDS 270605 271822 . + 0 ML0202 ML0202 Possible DNA polymerase ML0202, len: 405 aa. Possible DNA polymerase (EC 2.7.7.-), highly similar to Rv3644c|O06363|AL123456 possible DNA polymerase from M. tuberculosis (401 aa), Fasta scores: E(): 0, (84.4% identity in 404 aa overlap). Similar to the N-termini of many DNA polymerase III subunits e.g. HOLB_ECOLI|P28631 holB, DNA polymerase III, delta' subunit from Escherichia coli (334 aa), Fasta scores: E(): 2.9e-13, (35.1% identity in 205 aa overlap); and Q9X906 putative DNA polymerase from Streptomyces coelicolor A3(2) (401 aa). Previously sequenced as O69546|AL023093 (405 aa), Fasta scores: E(): 0, (100.0% identity in 405 aa overlap). Also similar to the N-terminus of ML2335 of M. leprae. Q7AQM2 No information pathways Q7AQM2 GO:0006260,GO:0003887,GO:0017111,GO:0000166,GO:0008408 Rv3644c Rv3644c AL450380.2 Mycobrowser_v4 CDS 678086 678556 . + 0 ML0561 ML0561 Possible conserved membrane protein ML0561, len: 156 aa. Possible conserved membrane protein, highly similar to YE17_MYCTU|P71686|Rv1417 Possible conserved membrane protein from M. tuberculosis (154 aa), Fasta scores: E(): 2.4e-43, (75.5% identity in 143 aa overlap); and CAD94313|Mb1452 from M. bovis (154 aa). Similar to other membrane proteins e.g. Q9RKZ5 Putative membrane protein from Streptomyces coelicolor (156 aa), fasta scores: E(): 2e-05, (27.891% identity in 147 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CCP2 No cell wall and cell processes PF10756 Q9CCP2 Rv1417 Rv1417 AL450380.2 Mycobrowser_v4 CDS 1242376 1242738 . + 0 ML1079 tatB Probable protein TatB ML1079, len: 120 aa. Probable TatB, component of twin-arginine translocation protein export system. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49973 (EMBL:U15180) (120 aa), Fasta scores: E(): 0, 98.3% identity in 120 aa overlap. Also highly similar to Mycobacterium tuberculosis TatB protein Rv1224 TR:O33220 (EMBL:Z98260) (131 aa), Fasta scores: E(): 0, (74.0% identity in 131 aa overlap). Also similar, in parts, to Escherichia coli TatB or MttA2, Sec-independent protein translocase, TR:O69415 (EMBL:AJ005830) (171 aa), Fasta scores: E(): 0.00022, 29.8% identity in 121 aa overlap. Contains a possible N-terminal signal sequence. Q9CCA4 No cell wall and cell processes Q9CCA4 GO:0016021,GO:0065002,GO:0009306,GO:0015450 Rv1224 Rv1224 AL450380.2 Mycobrowser_v4 CDS 266033 268876 . + 0 ML0200 topA Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (topt I) ML0200, len: 947 aa. Probable topA, DNA topoisomerase I (EC 5.99.1.2) (see citation below), highly similar to Rv3646c|TOP1_MYCTU|Q59567 topA, DNA topoisomerase I from M. tuberculosis (934 aa), Fasta scores: E(): 0, (84.3% identity in 942 aa overlap); and many other e.g. Q9X909|TOP1_STRCO DNA topoisomerase type I from Streptomyces coelicolor (952 aa). Previously sequenced as TOP1_MYCLE|O69548 (947 aa), Fasta scores: E(): 0, (100.0% identity in 947 aa overlap). Contains Pfam match to entry PF01131 Topoisom_bac, Prokaryotic DNA topoisomerase. Contains Pfam match to entry PF01751 Toprim, Toprim domain. Contains PS00396 Prokaryotic DNA topoisomerase I active site. Belongs to the prokaryotic typeI/III topoisomerase family. O69548 No information pathways PF01131,PF01751 O69548 GO:0003917,GO:0006265,GO:0006268,GO:0005694,GO:0005524 5.99.1.2 Rv3646c Rv3646c AL450380.2 Mycobrowser_v4 CDS 281543 282031 . - 0 ML0210c ppa Probable inorganic pyrophosphatase Ppa (pyrophosphate phospho-hydrolase_ (PPase) (inorganic diphosphatase) (Diphosphate phospho-hydrolase) ML0210c, len: 162 aa. Probable ppa, inorganic pyrophosphatase (EC 3.6.1.1), highly similar to Rv3628|IPYR_MYCTU|O06379 ppa, inorganic pyrophosphatase from M. tuberculosis (162 aa), Fasta scores: E(): 0, (89.5% identity in 162 aa overlap). Similar to many others e.g. IPYR_SULAC|P50308 ppa, inorganic pyrophosphatase from Sulfolobus acidocaldarius (173 aa), Fasta scores: E(): 1.1e-27, (45.9% identity in 159 aa overlap); and Q9X8I9|IPYR_STRCO inorganic pyrophosphatase from Streptomyces coelicolor A3(2) (163 aa). Previously sequenced as IPYR_MYCLE|O69540 (162 aa), Fasta scores: E(): 0, (99.4% identity in 162 aa overlap). Contains Pfam match to entry PF00719 Pyrophosphatase, Inorganic pyrophosphatase. Contains PS00387 Inorganic pyrophosphatase signature. O69540 No intermediary metabolism and respiration PF00719 O69540 GO:0004427,GO:0000287,GO:0006796,GO:0005737 3.6.1.1 Rv3628 Rv3628 AL450380.2 Mycobrowser_v4 CDS 302835 303659 . + 0 ML0232 ML0232 conserved hypothetical protein ML0232, len: 274 aa. Conserved hypothetical protein, highly similar to Rv3600c|O06282|AL123456 conserved hypothetical protein from M. tuberculosis (272 aa), Fasta scores: E(): 0, (90.5% identity in 274 aa overlap). Similar to several other bacterial hypothetical proteins e.g. Q9X8N6|AL049628 hypothetical protein SCE94.31C from Streptomyces coelicolor (265 aa), Fasta scores: E(): 0, (52.0% identity in 269 aa overlap); and other bacterial proteins e.g. Q9F985 putative 32 kDa replication protein from Bacillus stearothermophilus (258 aa). Q9CD56 No conserved hypotheticals PF03309 Q9CD56 GO:0015937,GO:0005737,GO:0046872,GO:0004594,GO:0045941,GO:0016563,GO:0005524 2.7.1.33 Rv3600c Rv3600c AL450380.2 Mycobrowser_v4 CDS 306003 308549 . + 0 ML0235 clpC Probable ATP-dependent Clp protease ATP-binding subunit ClpC ML0235, len: 848 aa. Probable clpC, ATP-dependent clp protease ATP-binding subunit (EC 3.4.-.-), equivalent to Rv3596c|CLPC_MYCTU|O06286 clpC, ATP-dependent clp protease ATP-binding subunit from M. tuberculosis (848 aa), Fasta scores: E(): 0, (97.2% identity in 845 aa overlap). Also highly similar to members of the clpA/clpB family e.g. P37571|CLPC_BACSU clpC, negative regulator of genetic competence (clpC-family) from Bacillus subtilis (810 aa), and HLYB_TREHY|Q54316 tlyB, hemolysin B from Treponema hyodysenteriae (828 aa), Fasta scores: E(): 0, (51.4% identity in 812 aa overlap). Also similar to ML2490 from M. leprae. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the clpA/clpB family, clpC subfamily. P24428 No intermediary metabolism and respiration PF00004,PF02151,PF02861,PF07724,PF10431 P24428 GO:0003677,GO:0004518,GO:0017111,GO:0006289,GO:0005515,GO:0019538,GO:0005524 Rv3596c Rv3596c AL450380.2 Mycobrowser_v4 CDS 1231780 1232007 . + 0 ML1067 ML1067 conserved hypothetical protein ML1067, len: 75 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49958 (EMBL:U15180) (75 aa), Fasta scores: E(): 1.9e-29, 100.0% identity in 75 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1211 TR:O05312 (EMBL:Z93777) (75 aa), Fasta scores: E(): 1.6e-26, 90.7% identity in 75 aa overlap. Q7AQ95 No conserved hypotheticals Q7AQ95 Rv1211 Rv1211 AL450380.2 Mycobrowser_v4 CDS 316048 316968 . + 0 ML0241 ksgA Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase) ML0241, len: 306 aa. Probable ksgA, dimethyladenosine transferase (EC 2.1.1.-), highly similar to Rv1010|O05595|AL123456 ksgA, dimethyladenosine transferase from M. tuberculosis (317 aa), Fasta scores: E(): 0, (85.0% identity in 294 aa overlap). Similar to many e.g. KSGA_ECOLI|M68521 ksgA, dimethyladenosine transferase from Escherichia coli (273 aa), Fasta scores: E(): 8.3e-23, (33.7% identity in 261 aa overlap). Contains Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine dimethylases. Contains PS01131 Ribosomal RNA adenine dimethylases signature. Q9CD52 No information pathways PF00398 Q9CD52 GO:0000179,GO:0000154,GO:0046677,GO:0003723 2.1.1.- Rv1010 Rv1010 AL450380.2 Mycobrowser_v4 CDS 318220 319854 . + 0 ML0243 pks16 Putative polyketide synthetase Pks16 ML0243, len: 544 aa. Putative pks16, polyketide synthase, highly similar to Rv1013|O05598|AL123456 putative pks16, polyketide synthases from M. tuberculosis (544 aa), Fasta scores: E(): 0, (82.2% identity in 544 aa overlap); and other M. tuberculosis putative acyl-CoA synthases e.g. fadD33|Rv1345 (521 aa), fadD26|Rv2930 (583 aa). Similar to domains of other polyketide synthases e.g. Q9R9J1|AF184956 mycA, mycosubtilin synthetase from Bacillus subtilis (3971 aa), Fasta scores: E(): 0, (33.7% identity in 404 aa overlap). Also similar to ML0887, ML0100, ML0132, ML0138, ML1051, ML1234, ML1994, ML2358 and ML2546 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Q9CD50 No lipid metabolism PF00501 Q9CD50 GO:0008152,GO:0003824 Rv1013 Rv1013 AL450380.2 Mycobrowser_v4 CDS 323462 324445 . - 0 ML0248c prsA Catalyzes the formation of PRPP from ATP and ribose 5-phosphate. PRPP is then used in various biosynthetic pathways, as for example in the formation of purines, pyrimidines, histidine and tryptophan. [Catalytic activity: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate] Probable ribose-phosphate pyrophosphokinase PrsA (Phosphoribosyl pyrophosphate synthetase) (PRPP synthetase) ML0248c, len: 327 aa. Probable prsA, ribose-phosphate pyrophosphokinase (EC 2.7.6.1), equivalent to Rv1017c|P96383|AL123456 prsA, ribose-phosphate pyrophosphokinase from M. tuberculosis (326 aa), Fasta scores: E(): 0, (92.0% identity in 326 aa overlap). Similar to others e.g. SW:KPRS_BACSU|P14193 prs, ribose-phosphate pyrophosphokinase from Bacillus subtilis (317 aa), Fasta scores: E(): 0, (45.8% identity in 323 aa overlap). Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Belongs to the ribose-phosphate pyrophosphokinase family. Cofactor: both inorganic phosphate and magnesium ion are required for enzymes stability and activity. Q9CD45 No intermediary metabolism and respiration PF00156 Q9CD45 GO:0044249,GO:0005737,GO:0016301,GO:0000287,GO:0009116,GO:0009156,GO:0004749,GO:0005524 2.7.6.1 Rv1017c Rv1017c AL450380.2 Mycobrowser_v4 CDS 357557 358777 . - 0 ML0275c metZ Probable O-succinylhomoserine sulfhydrylase MetZ (osh sulfhydrylase) ML0275c, len: 406 aa. Probable metZ, O-succinylhomoserine sulfhydrylase (EC 4.2.99.-), equivalent, but shorter 20 aa in N-terminus to Rv0391|P95199|AL123456 metZ, o-succinylhomoserine sulfhydrylase from M. tuberculosis (406 aa), Fasta scores: E(): 0, (87.9% identity in 406 aa overlap). Similar to many others e.g. METZ_PSEAE|P55218 metZ, o-succinylhomoserine sulfhydrylase from Pseudomonas aeruginosa (403 aa), Fasta scores: E(): 0, (44.3% identity in 406 aa overlap). Previously sequenced as O69592|AL023514 (426 aa), Fasta scores: E(): 0, (100.0% identity in 406 aa overlap). Also similar to ML2394 from M. leprae. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. Belongs to the trans-sulfuration enzymes family. Could also be a cystathionine gamma-synthase (EC 4.2.99.9). Q9CCX4 No intermediary metabolism and respiration PF01053 Q9CCX4 GO:0003824,GO:0030170,GO:0006520 Rv0391 Rv0391 AL450380.2 Mycobrowser_v4 CDS 368449 369117 . + 0 ML0287 ML0287 Possible conserved transmembrane protein ML0287, len: 222 aa. Possible conserved transmembrane protein, highly similar to Rv0364|Y364_MYCTU|O06314 conserved transmembrane protein from M. tuberculosis (227 aa), Fasta scores: E(): 0, (66.1% identity in 227 aa overlap). Similar to many dedA-family proteins e.g. Q9X8J1|AL049841 possible membrane protein SCE9.18C from Streptomyces coelicolor (303 aa), Fasta scores: E(): 0, (42.8% identity in 201 aa overlap). Previously sequenced as O69601|AL023514 (222 aa), Fasta scores: E(): 0, (100.0% identity in 222 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00597 DedA, DedA family. Belongs to the DedA family. O69601 No cell wall and cell processes PF09335 O69601 GO:0005886,GO:0016021 Rv0364 Rv0364 AL450380.2 Mycobrowser_v4 CDS 377487 379130 . + 0 ML0294 thiC Probable thiamine biosynthesis protein ThiC ML0294, len: 547 aa. Probable thiC, thiamin biosynthesis protein, equivalent to Rv0423c|THIC_MYCTU|P96269 thiC, thiamine biosynthesis protein from M. tuberculosis (547 aa), Fasta scores: E(): 0, (90.1% identity in 547 aa overlap). Similar to many others e.g. THIC_ECOLI|P30136 thiC, thiamine biosynthesis protein from Escherichia coli (631 aa), Fasta scores: E(): 0, (59.2% identity in 593 aa overlap). Previously sequenced as THIC_MYCLE|Q9ZBL0 (547 aa), Fasta scores: E(): 0, (100.0% identity in 547 aa overlap). Contains Pfam match to entry PF01964 ThiC, ThiC family. Belongs to the ThiC family. Q9ZBL0 No intermediary metabolism and respiration PF01964 Q9ZBL0 GO:0009228 Rv0423c Rv0423c AL450380.2 Mycobrowser_v4 CDS 1152705 1152908 . + 0 ML0986 ML0986 conserved hypothetical protein ML0986, len: 67 aa. Conserved hypothetical protein. Highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv2738c TR:O33281 (EMBL:AL008967) (68 aa), Fasta scores: E(): 7.9e-24, 85.1% identity in 67 aa overlap and Streptomyces coelicolor TR:O50484 (EMBL:AL020958) (64 aa), Fasta scores: E(): 2.5e-08, 44.4% identity in 63 aa overlap. Q9CCC1 No conserved hypotheticals Q9CCC1 Rv2738c Rv2738c AL450380.2 Mycobrowser_v4 CDS 380645 381430 . - 0 ML0297c thiG Probable thiamine biosynthesis protein ThiG (Thiazole biosynthesis protein) ML0297c, len: 261 aa. Probable thiG, thiamine biosynthesis protein, highly similar to Rv0417|P96263|AL123456 thiG, thiamine biosynthesis protein from M. tuberculosis (252 aa), Fasta scores: E(): 0, (86.8% identity in 250 aa overlap). Similar to many proteins involved in the biosynthesis of the thiazole moiety of thiamine e.g. THIG_ECOLI|P30139 thiG, thiamine biosynthetic protein (thiazole moiety) from Escherichia coli (281 aa), Fasta scores: E(): 0, (51.2% identity in 244 aa overlap). Previously sequenced as Q9ZBL2|AL035159 (261 aa), Fasta scores: E(): 0, (99.6% identity in 261 aa overlap). Belongs to the thiG family. Q9ZBL2 No intermediary metabolism and respiration PF05690 Q9ZBL2 GO:0005737,GO:0009228,GO:0003824 Rv0417 Rv0417 AL450380.2 Mycobrowser_v4 CDS 470283 470768 . + 0 ML0377 ML0377 Conserved hypothetical protein ML0377, len: 161 aa. Conserved hypothetical protein, highly similar to Rv3422c|YY22_MYCTU|Q50706 conserved hypothetical protein from M. tuberculosis (168 aa), Fasta scores: E(): 0, (77.4% identity in 146 aa overlap). Similar to many other bacterial hypothetical proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces coelicolor (148 aa), Fasta scores: E(): 0, (48.3% identity in 120 aa overlap). Previously sequenced as YY22_MYCLE|Q49864 (161 aa), Fasta scores: E(): 0, (100.0% identity in 161 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q49864 No conserved hypotheticals PF02367 Q49864 GO:0005524 Rv3422c Rv3422c AL450380.2 Mycobrowser_v4 CDS 904069 904566 . + 0 ML0762 ML0762 Conserved hypothetical protein ML0762, len: 165 aa. Conserved hypothetical protein, highly similar to Rv3258c|MTV015.03c|O53351|AL021840 Conserved hypothetical protein from Mycobacterium tuberculosis (163 aa), fasta scores: E(): 0, (76.9% identity in 169 aa overlap), and CAD95378| from M. bovis (163 aa). Similar to other hypothetical proteins e.g. Q9KZL4|AL353862|SCE34.11C hypothetical protein from Streptomyces coelicolor (140 aa), fasta scores: E(): 4.8e-16, (47.0% identity in 151 aa). Q9CCJ8 No conserved hypotheticals Q9CCJ8 Rv3258c Rv3258c AL450380.2 Mycobrowser_v4 CDS 113153 113863 . - 0 ML0091c pirG Exported repetitive protein precursor PirG (28 KDa antigen precursor) (cell surface protein) ML0091c, len: 236 aa. Probable pirG (alternate gene names: P36 or erp for Exported Repeated Protein), cell surface protein precursor (see citations below), similar to Rv3810|ERP_MYCTU|Q50793 pirG, exported repetitive protein precursor from M. tuberculosis (284 aa), Fasta scores: E(): 1.8e-23, (52.7% identity in 281 aa overlap). Previously sequenced as 28KD_MYCLE|P19361 (236 aa), Fasta scores: E(): 0, (99.6% identity in 236 aa overlap). Contains a probable N-terminal signal sequence. P19361 No cell wall and cell processes P19361 Rv3810 Rv3810 AL450380.2 Mycobrowser_v4 CDS 92647 93270 . - 0 ML0072c sodA Probable superoxide dismutase SodA ML0072c, len: 207 aa. Probable sodA (alternate gene names: sodB, sod), superoxide dismutase (EC 1.15.1.1) (see citations below), highly similar to Rv3846|SODF_MYCTU|P17670 sodA, superoxide dismutase from M. tuberculosis (207 aa), Fasta scores: E(): 0, (80.1% identity in 206 aa overlap); and to many other mycobacterial superoxide dismutases. Previously sequenced as SODM_MYCLE|P13367 (206 aa), Fasta scores: E(): 0, (100.0% identity in 206 aa overlap). Contains Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases (SODM). Contains PS00088 Manganese and iron superoxide dismutases signature. Belongs to the iron/manganese superoxide dismutase family. In M. tuberculosis has been found extracellularly, no signal sequence is present. An alternative secretory pathway may be used. P13367 No virulence, detoxification, adaptation PF00081,PF02777 P13367 GO:0055114,GO:0004784,GO:0006801,GO:0030145 1.15.1.1 Rv3846 Rv3846 AL450380.2 Mycobrowser_v4 CDS 192013 193752 . - 0 ML0138c fadD28 Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) ML0138c, len: 579 aa. Probable fadD28 (alternate gene name: acoas), fatty-acid-CoA synthetase (EC 6.2.1.-) (see citations below), highly similar to several fatty-acyl-CoA synthases from M. tuberculosis e.g. Rv2941|P96290|AL123456 fadD29 (580 aa), Fasta scores: E(): 0, (81.9% identity in 580 aa overlap); and to P71495|U75685 fatty-acyl-CoA synthases from Mycobacterium bovis BCG (582 aa), Fasta scores: E(): 0, (81.4% identity in 580 aa overlap). Similar to the domains of some polyketide synthases e.g. Q50857|U24657 safB, saframycin Mx1 synthetase B from Myxococcus xanthus (1770 aa), Fasta scores: E(): 0, (35.8% identity in 590 aa overlap). And similar to ML0100, ML0132, ML0243, ML1234, ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Q9CD79 No lipid metabolism PF00501 Q9CD79 GO:0008152,GO:0003824 Rv2941 Rv2941 AL450380.2 Mycobrowser_v4 CDS 903526 904029 . - 0 ML0761c ML0761c conserved hypothetical protein ML0761c, len: 167 aa. Conserved hypothetical protein, highly similar but longer than Rv3259|MTV015.04|O53352|AL021840 Conserved hypothetical protein from Mycobacterium tuberculosis (139 aa), fasta scores: E(): 6.9e-56, (89.2% identity in 139 aa); and CAD95379| from M. bovis (139 aa). Also similar to Q9S425|AF164439 hypothetical 6.0 kDa protein (partial CDS) from Mycobacterium smegmatis (54 aa), fasta scores: E(): 1e-10, (75.5% identity in 53 aa); and Q9KZL3 Hypothetical protein SCO3031 from Streptomyces coelicolor (117 aa), FASTA scores: E(): 0.012, (30.159% identity in 126 aa overlap). Q9CCJ9 No conserved hypotheticals Q9CCJ9 Rv3259 Rv3259 AL450380.2 Mycobrowser_v4 CDS 353007 354017 . - 0 ML0269c fgd1 Probable F420-dependent glucose-6-phosphate dehydrogenase Fgd1 ML0269c, len: 336 aa. Probable fgd1, F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), highly similar to others from Mycobacteria e.g. Rv0407|P96253|AL123456 from M. tuberculosis (336 aa), Fasta scores: E(): 0, (89.3% identity in 336 aa overlap); and Q9XC15|AF152394 from Mycobacterium avium (336 aa), Fasta scores: E(): 0, (88.4% identity in 336 aa overlap). And similar to other dehydrogenases e.g. putative dehydrogenase from Streptomyces coelicolor A3(2) (325 aa). Previously sequenced as O69589|AL023514 (336 aa), Fasta scores: E(): 0, (100.0% identity in 336 aa overlap). Also shows weak similarity to ML0131 from M. leprae. Note that previously known as fgd. Q7AQK8 No intermediary metabolism and respiration PF00296 Q7AQK8 GO:0016491,GO:0055114 Rv0407 Rv0407 AL450380.2 Mycobrowser_v4 CDS 85968 86612 . - 0 ML0064c ethR Probable transcriptional regulatory repressor protein (TetR-family) EthR ML0064c, len: 214 aa. Probable ethR (alternate gene names: aka, etaR), regulatory protein tetR family, involved in ethionamide sensitivity/resistance. Probably negatively controls neighbouring ethA (ML0065, alternate gene names: aka etaA) (see citations below). Highly similar to Rv3855|P96222|Al123456 ethR, regulatory protein tetR family protein from M. tuberculosis (216 aa), Fasta scores: E(): 0, (77.0% identity in 213 aa overlap). Also some similarity to other transcriptional regulators e.g. Q9S1R1 putative tetR-family transcriptional regulator from Streptomyces coelicolor A3 (204 aa), Fasta scores: E(): 0, (29.1% identity in 196 aa overlap). And similar to ML1070 from M. leprae. Contains a probable helix-turn-helix motif at aa 45-66 (Score 1261, SD +3.48) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Belongs to the TetR/AcrR family of transcriptional regulators. Q9CDD3 No regulatory proteins PF00440 Q9CDD3 GO:0006355,GO:0016566,GO:0003700,GO:0016481 Rv3855 Rv3855 AL450380.2 Mycobrowser_v4 CDS 867697 869493 . - 0 ML0726c accA3 INVOLVED IN LONG-CHAIN FATTY ACID SYNTHESIS (AT THE FIRST STEP). CARRIES TWO FUNCTIONS: BIOTIN CARBOXYL CARRIER PROTEIN AND BIOTIN CARBOXYLTRANSFERASE [CATALYTIC ACTIVITY: ATP + BIOTIN-CARBOXYL-CARRIER PROTEIN + CO(2) = ADP + ORTHOPHOSPHATE + CARBOXYBIOTIN-CARBOXYL-CARRIER PROTEIN]. Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) ML0726c, len: 598 aa. Probable accA3, bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (EC 6.3.4.14), highly similar to P96890|AL123456|Rv3285 Probable accA3, bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain from M. tuberculosis (600 aa), Fasta scores: E(): 0, (88.7% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC ACYL COENZYME A CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776, E(): 8.6e-163, (70.202% identity in 594 aa overlap); Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa), FASTA scores: E(): 2.1e-139, (69.192% identity in 594 aa overlap). Previously sequenced as BCCA_MYCLE|P46392 (598 aa), Fasta scores: E(): 0, (99.7% identity in 598 aa overlap). Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes. Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. Contains PS00188 Biotin-requiring enzymes attachment site. Note previously known as bccA P46392 No lipid metabolism PF00289,PF00364,PF02785,PF02786 P46392 GO:0009374,GO:0004075,GO:0006633,GO:0005524 6.3.4.14 Rv3285 Rv3285 AL450380.2 Mycobrowser_v4 CDS 22189 23667 . - 0 ML0018c pbpA Probable penicillin-binding protein PbpA ML0018c, len: 492 aa. Probable pbpA, penicillin-binding protein, highly similar to Rv0016c|P71586|AL123456 pbpA, penicillin-binding protein from M. tuberculosis (491 aa), Fasta scores: E(): 0, (85.7% identity in 490 aa overlap). Also similar to PBPC_BACSU|P42971 pbpC, penicillin-binding protein 3 from Bacillus subtilis (668 aa), Fasta scores: E(): 2.8e-15, (24.5% identity in 444 aa overlap). Also similar to region of ML1577. Previously sequenced as Q50185|Z70722 (474 aa), Fasta scores: E(): 0, (96.4% identity in 472 aa overlap). Contains a probable N-terminal signal sequence. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Q9CDE6 No cell wall and cell processes PF00905 Q9CDE6 GO:0009273,GO:0008658 Rv0016c Rv0016c AL450380.2 Mycobrowser_v4 CDS 723255 724511 . + 0 ML0596 csd Probable cysteine desulfurase Csd ML0596, len: 418 aa. Probable csd, cysteine desulfurase (EC 4.4.1.- ), highly similar to O53155|AL123456|Rv1464 Probable csd, cysteine desulfurase from M. tuberculosis (417 aa), Fasta scores: E(): 0, (85.4% identity in 417 aa overlap); and CAD96166|Mb1499 from M. bovis (417 aa). Similar to others e.g. Q9XAD5|CSD_STRCO Probable cysteine desulfurase from streptomyces coelicolor (418 aa), fasta scores: E(): 2.5e-88, (53.382% identity in 414 aa overlap). Previously sequenced as Q49690|U00013 (418 aa), Fasta scores: E(): 0, (100.0% identity in 418 aa overlap). And similar to part of ML0842 and to ML0117 and ML1708. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. Belongs to the class-V of pyridoxal-phosphate-dependent aminotransferases. Csd subfamily. Q49690 No intermediary metabolism and respiration PF00266 Q49690 GO:0006534,GO:0030170,GO:0031071 2.8.1.7 Rv1464 Rv1464 AL450380.2 Mycobrowser_v4 CDS 654435 656051 . + 0 ML0539 PPE PPE-family protein ML0539, len: 538 aa. Member of the Mycobacteria PPE family, highly similar to P71657|AL123456|Rv1387 PPE20, PPE-family protein from M. tuberculosis (539 aa), Fasta scores: E(): 2.4e-119, (69.5% identity in 544 aa overlap); CAD94283|Mb1422 from M. bovis (539 aa). And similar to ML0411, ML1182, ML1828 and ML1991. Contains Pfam match to entry PF00823 PPE, PPE family. Q9CCQ9 No PE/PPE PF00823 Q9CCQ9 Rv1387 Rv1387 AL450380.2 Mycobrowser_v4 CDS 161741 162577 . - 0 ML0120c echA1 Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-coA hydratase) (crotonase) ML0120c, len: 278 aa. Possible echA21, enoyl-CoA hydratase (EC 4.2.1.17), highly similar to Rv3774|P75019|AL123456 possible echA21, enoyl-CoA hydratase from M. tuberculosis (274 aa), Fasta scores: E(): 0, (88.3% identity in 274 aa overlap); and similar to many others e.g. ECH1_RAT|Q62651 ech1, delta3,5-delta2,4-dienoyl-coa isomerase precursor from Rattus norvegicus (327 aa), Fasta scores: E(): 3.5e-31, (38.8% identity in 276 aa overlap). Also shows some similarity to bacterial putative enoyl-CoA hydratases. And similar to ML1241, ML1724, ML2118 and ML2402 from M. leprae. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Q9CD94 No lipid metabolism PF00378 Q9CD94 GO:0008152,GO:0003824 Rv3774 Rv3774 AL450380.2 Mycobrowser_v4 CDS 136573 139824 . - 0 ML0104c embB Involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). Polymerizes arabinose into the arabinan of arabiogalactan [Catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]. Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) ML0104c, len: 1083 aa. Probable embB, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), highly similar to Rv3795|P72030|AL123456 embB, probable indolylacetylinositol arabinosyltransferase from M. tuberculosis (1098 aa), Fasta scores: E(): 0, (78.0% identity in 1101 aa overlap); and to other putative mycobacterial arabinosyltransferases. Also similar to ML0105 and ML0106 from M. leprae. Involved in resistance to ethambutol in M. tuberculosis. In M. tuberculosis embA is thought to be regulated by embR, but this regulator doesn't exist in M. leprae. Contains hydrophobic, possible membrane-spanning regions. Q9CDA9 No cell wall and cell processes PF04602 Q9CDA9 GO:0016021,GO:0009252,GO:0005886,GO:0016763,GO:0007047 2.4.2.- Rv3795 Rv3795 AL450380.2 Mycobrowser_v4 CDS 496061 497098 . - 0 ML0398c ML0398c Possible D-ribose-binding protein ML0398c, len: 345 aa. Possible D-ribose-binding protein, similar to many D-ribose-binding proteins e.g. RBSB_BACSU|P36949 rbsB, D-ribose-binding protein precursor from Bacillus subtilis (305 aa), Fasta scores: E(): 2e-16, (32.6% identity in 273 aa overlap). Previously sequenced as Q49738|U00015) (345 aa), Fasta scores: E(): 0, (100.0% identity in 345 aa overlap). Contains probable N-terminal signal sequence. Contains Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family. Q49738 No cell wall and cell processes PF00532 Q49738 AL450380.2 Mycobrowser_v4 CDS 86681 88165 . + 0 ML0065 ethA Probable monooxygenase EthA ML0065, len: 494 aa. Probable ethA (alternate gene names: aka, etaA), monooxygenase required for activation of the pro-drug ethionamide (EC 1.-.-.-) (see citations below), highly similar to other M. tuberculosis monooxygenases e.g. Rv3854c|P96223|AL123456 ethA, monooxygenase (489 aa), Fasta scores: E(): 0, (80.1% identity in 488 aa overlap); and Rv0892 and Rv1393c. Also similar to the C-terminal half of Q9RZT0|AE001826 putative arylesterase/monoxygenase from Deinococcus radiodurans (833 aa), Fasta scores: E(): 0, (51.5% identity in 480 aa overlap). Shows weaker similarity to O50641|AB010439 steroid monooxygenase from Rhodococcus rhodochrous (549 aa), Fasta scores: E(): 2e-15, (24.9% identity in 469 aa overlap). Also similar to pseudogene ML1732. Contains Pfam match to entry PF00743 FMO-like, Flavin-binding monooxygenase-like. Q7AQN8 No intermediary metabolism and respiration PF01266 Q7AQN8 GO:0004497 Rv3854c Rv3854c AL450380.2 Mycobrowser_v4 CDS 312208 313821 . - 0 ML0238c metS It is probably essential for cell survival, being required not only for elongation of protein synthesis but also for the initiation of all mRMA translation through initiator tRNA(Fmet) aminoacylation [Catalytic activity: ATP + L-methionine + tRNA(met) = AMP + diphosphate + L-methionyl-tRNA(met)] Probable methionyl-tRNA synthase MetS ML0238c, len: 537 aa. Probable metS (MetG), methionyl-tRNA synthetase (EC 6.1.1.10), highly similar to Rv1007c|SYM_MYCTU|O05593 metS, methionyl-tRNA synthetase from M. tuberculosis (519 aa), Fasta scores: E(): 0, (85.7% identity in 516 aa overlap). Similar to several others e.g. SYM_BACST|P23920 metG (metS), methionyl-tRNA synthetase from Bacillus stearothermophilus (649 aa), Fasta scores: E(): 0, (40.9% identity in 550 aa overlap). Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family. Strong, to cysteinyl-tRNA synthetase. Q9CD55 No information pathways PF09334 Q9CD55 GO:0005737,GO:0004825,GO:0006431,GO:0005524 6.1.1.10 Rv1007c Rv1007c AL450380.2 Mycobrowser_v4 CDS 247094 248014 . + 0 ML0182 galU Probable UTP--glucose-1-phosphate uridylyltransferase GalU (UDP-glucose pyrophosphorylase) (UDPGP) (alpha-D-glucosyls-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase) ML0182, len: 306 aa. Probable galU, UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9), highly similar to Rv0993|O05576|AL123456 galU, UTP--glucose-1-phosphate uridylyltransferase from M. tuberculosis (306 aa), Fasta scores: E(): 0, (89.7% identity in 302 aa overlap). Similar to many others e.g. GALU_ECOLI|P25520 galU, UTP--glucose-1-phosphate uridylyltransferase from Escherichia coli (301 aa), Fasta scores: E(): 5.4e-33, (38.8% identity in 299 aa overlap). Previously sequenced as Q9Z5G1|AL035500 (306 aa), Fasta scores: E(): 0, (100.0% identity in 306 aa overlap). Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Belongs to the prokaryotic UDPGP family. Q9Z5G1 No intermediary metabolism and respiration PF00483 Q9Z5G1 GO:0016779,GO:0009058 Rv0993 Rv0993 AL450380.2 Mycobrowser_v4 CDS 82285 83751 . + 0 ML0062 gltD Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (NADH-GOGAT) ML0062, len: 488 aa. Probable gltD, small subunit of NADH-dependent glutamate synthase (EC 1.4.1.13), highly similar to Rv3858c|P96219|Al123456 gltD, probable NADH-dependent glutamate synthase small subunit from M. tuberculosis (488 aa), Fasta scores: E(): 0, (87.7% identity in 488 aa overlap); and similar to many other putative glutamate synthase small subunits e.g. GLTD_ECOLI|P09832 gltD, glutamate synthase [NADPH] small chain from Escherichia coli (471 aa), Fasta scores: E(): 0, (37.8% identity in 474 aa overlap). Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Q9CDD4 No intermediary metabolism and respiration PF00070,PF07992 Q9CDD4 GO:0009055,GO:0006537,GO:0004355,GO:0051536,GO:0055114,GO:0050660 1.4.1.13 Rv3858c Rv3858c AL450380.2 Mycobrowser_v4 CDS 285584 286225 . + 0 ML0214 hpt Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP phosphoribosyltransferase) (IMP diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase) ML0214, len: 213 aa. Probable hpt (alternate gene name: hprT), hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8), highly similar to other mycobacterial hypoxanthine-guanine phosphoribosyltransferases e.g. Rv3624c|HPRT_MYCTU|O06383 from M. tuberculosis (216 aa), Fasta scores: E(): 0, (83.1% identity in 207 aa overlap); and P96794|HPRT_MYCAV from M. avium (203 aa). And similar to many other bacterial hypoxanthine phosphoribosyltransferases e.g. O33799|AF008931 from Salmonella typhimurium (178 aa), Fasta scores: E(): 9.6e-32, (50.9% identity in 169 aa overlap). Previously sequenced as O69537|AL023093 (213 aa), Fasta scores: E(): 0, (99.5% identity in 213 aa overlap). Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Belongs to the purine/pyrimidine phosphoribosyltransferase family O69537 No intermediary metabolism and respiration PF00156 O69537 GO:0004422,GO:0000287,GO:0006166,GO:0005737 2.4.2.8 Rv3624c Rv3624c AL450380.2 Mycobrowser_v4 CDS 473178 473480 . + 0 ML0380 groES 10 kD chaperonin GroES (Protein Cpn10) (groES protein) (BCG-A heat shock protein) (10 kDa antigen) ML0380, len: 100 aa. groES (alternate gene names: cpn10, mpt57), 10 kDa chaperonin (protein cpn10) (see citations below), equivalent to Rv3418c|CH10_MYCTU|P09621 groES, 10 kD chaperonin from M. tuberculosis (100 aa), Fasta scores: E(): 3.6e-32, (89.9% identity in 99 aa overlap). Also highly similar to others e.g. P15020|CH10_MYCBO|MOPB|GROES from Mycobacterium bovis (99 aa), and P40172|CH10_STRCO|GROES|SC6G4.39 from Streptomyces coelicolor and Streptomyces lividans (102 aa). Previously sequenced as CH10_MYCLE|P24301 (99 aa), Fasta scores: E(): 0, (100.0% identity in 99 aa overlap). Contains Pfam match to entry PF00166 cpn10, Chaperonins 10 Kd subunit. Contains PS00681 Chaperonins cpn10 signature. Belongs to the groES chaperonin family. P24301 No virulence, detoxification, adaptation 1LEP PF00166 P24301 GO:0005737,GO:0006457,GO:0006950,GO:0005524 Rv3418c Rv3418c AL450380.2 Mycobrowser_v4 CDS 36321 39239 . + 0 ML0032 leuS Probable leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase) ML0032, len: 972 aa. Probable leuS, leucyl-tRNA synthetase (EC 6.1.1.4), highly similar to Rv0041|SYL_MYCTU|P71698 leuS, leucyl-tRNA synthetase from M. tuberculosis (969 aa), Fasta scores: E(): 0, (83.6% identity in 972 aa overlap) and similar to SYL_BACSU|P36430 leuS, leucyl-tRNA synthetase from Bacillus subtilis (804 aa), Fasta scores: E(): 0, (45.7% identity in 941 aa overlap). Previously sequenced as SYL_MYCLE|Q50192 (972 aa), Fasta scores: E(): 0, (99.9% identity in 972 aa overlap). Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to the class-I aminoacyl-tRNA synthetase family. Q50192 No information pathways PF08264,PF09334 Q50192 GO:0005737,GO:0004823,GO:0006429,GO:0005524 6.1.1.4 Rv0041 Rv0041 AL450380.2 Mycobrowser_v4 CDS 25058 26587 . - 0 ML0020c pstP Possible serine/threonine phosphatase PstP ML0020c, len: 509 aa. Possible pstP, serine/threonine phosphatase (EC 3.1.3.16), highly similar to Rv0018c|P71588|AL123456 ppp, serine/threonine phosphatase from M. tuberculosis (514 aa), Fasta scores: E(): 0, (76.4% identity in 513 aa overlap); and similar to Q9XA19|AL079308 possible protein phosphatase from Streptomyces coelicolor (515 aa), Fasta scores: E(): 0, (40.2% identity in 532 aa overlap). Also similar to many other proteins of undefined function. Previously sequenced as Q50188|Z70722 (509 aa), Fasta scores: E(): 0, (99.6% identity in 509 aa overlap). Contains hydrophobic, possible membrane-spanning region. Proline-rich C-terminus. Previously known as ppp. Q9CDE5 No regulatory proteins PF00481 Q9CDE5 GO:0003824 Rv0018c Rv0018c AL450380.2 Mycobrowser_v4 CDS 175441 176589 . + 0 ML0131 ML0131 Possible oxidoreductase ML0131, len: 382 aa. Possible oxidoreductase (EC 1.-.-.-), highly similar to Rv2951c|P95140|AL123456 possible oxidoreductase from M. tuberculosis (381 aa), Fasta scores: E(): 0, (84.8% identity in 382 aa overlap). Similar to O30260|AE001109 conserved hypothetical protein from Archaeoglobus fulgidus AF2411 (363 aa), Fasta scores: E(): 0, (31.5% identity in 362 aa overlap). Shows weak similarity to bacterial oxidoreductases e.g. O68447|AF041061 fgd, F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis (336 aa), Fasta scores: E(): 1.1e-09, (27.7% identity in 292 aa overlap). Shows weak similarity to ML0269 from M. leprae. Q9CD85 No intermediary metabolism and respiration Q9CD85 GO:0055114,GO:0016491,GO:0008610 1.2.-.- Rv2951c Rv2951c AL450380.2 Mycobrowser_v4 CDS 282157 283542 . + 0 ML0211 ML0211 Possible carboxypeptidase ML0211, len: 461 aa. Possible carboxypeptidase, highly similar to Rv3627c|O06380|AL123456 hypothetical ala-rich protein from M. tuberculosis (461 aa), Fasta scores: E(): 0, (76.0% identity in 462 aa overlap). Shows weak similarity to penicillin-binding proteins e.g. O85665|AF071224 pbp3, penicillin binding protein 3 from Neisseria gonorrhoeae (469 aa), Fasta scores: E(): 4.5e-08, (33.1% identity in 163 aa overlap). Also similar to putative carboxypeptidases from Streptomyces coelicolor e.g. Q9X8I8|AL049841 SCE9.15C, possible penicillin-binding protein (459 aa), Fasta scores: E(): 3.8e-32, (36.3% identity in 435 aa overlap). Previously sequenced as O69539|AL023093 (461 aa), Fasta scores: E(): 0, (99.8% identity in 461 aa overlap). Also similar to ML2215 a possible pseudogene similar to M. tuberculosis Rv3627c. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF02113 Peptidase_S13, D-Ala-D-Ala carboxypeptidase 3 (S13) family. Q7AQL6 No cell wall and cell processes, conserved hypotheticals PF02113 Q7AQL6 GO:0004185,GO:0006508 Rv3627c Rv3627c AL450380.2 Mycobrowser_v4 CDS 301463 302404 . + 0 ML0230 panC Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) ML0230, len: 313 aa. Probable panC, pantoate--beta-alanine ligase (EC 6.3.2.1), highly similar to Rv3602c|PANC_MYCTU|O06280 panC, pantoate--beta-alanine ligase from M. tuberculosis (309 aa), Fasta scores: E(): 0, (82.2% identity in 297 aa overlap). Similar to many others e.g. PANC_ECOL|P31663 panC, pantoate--beta-alanine ligase from Escherichia coli (283 aa), Fasta scores: E(): 0, (46.1% identity in 269 aa overlap). Previously sequenced as PANC_MYCLE|O69524 (191 aa), Fasta scores: E(): 0, (100.0% identity in 191 aa overlap). Belongs to the pantothenate synthetase family. O69524 No intermediary metabolism and respiration PF02569 O69524 GO:0005737,GO:0004592,GO:0015940,GO:0005524 6.3.2.1 Rv3602c Rv3602c AL450380.2 Mycobrowser_v4 CDS 361950 363248 . - 0 ML0280c purA Probable adenylosuccinate synthase PurA (IMP--aspartate ligase) (AdSS) (AMPSase) ML0280c, len: 432 aa. Probable purA, adenylosuccinate synthase (EC 6.3.4.4), highly similar to Rv0357c|PURA_MYCTU|O08381 purA, adenylosuccinate synthase from M. tuberculosis (432 aa), Fasta scores: E(): 0, (87.9% identity in 431 aa overlap). Similar to many others e.g. PURA_ECOLI|P12283 purA, adenylosuccinate synthase from Escherichia coli (431 aa), Fasta scores: E(): 0, (51.1% identity in 425 aa overlap). Previously sequenced as PURA_MYCLE|O69595 (432 aa), Fasta scores: E(): 0, (100.0% identity in 432 aa overlap). Contains Pfam match to entry PF00709 Adenylsucc_synt, Adenylosuccinate synthetase. Contains PS00513 Adenylosuccinate synthetase active site. Contains PS01266 Adenylosuccinate synthetase GTP-binding site. Belongs to the adenylosuccinate synthetase family. O69595 No intermediary metabolism and respiration PF00709 O69595 GO:0004019,GO:0005737,GO:0000287,GO:0006164,GO:0005525 6.3.4.4 Rv0357c Rv0357c AL450380.2 Mycobrowser_v4 CDS 23664 25061 . - 0 ML0019c rodA Probable cell-division protein RodA ML0019c, len: 465 aa. Probable rodA (alternate gene name: ftsW), cell division protein, integral membrane protein, highly similar to Rv0017c|P71587 rodA, cell-division protein from M. tuberculosis (469 aa), Fasta scores: E(): 0, (82.3% identity in 469 aa overlap) and similar to Q9ZBA6|AL109663 ftsW, cell-division protein from Streptomyces coelicolor (456 aa), Fasta scores: E(): 3.3e-25, (32.1% identity in 377 aa overlap). Also similar to ML0913 from m. leprae. Previously sequenced as FTSW_MYCLE|Q50186 (465 aa), Fasta scores: E(): 0, (99.6% identity in 465 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains PS00428 Cell cycle proteins ftsW/rodA/spoVE signature. Belongs to the FtsW/RodA/SpoVE family. Q50186 No cell wall and cell processes PF01098 Q50186 GO:0051301,GO:0007047,GO:0016021,GO:0009252,GO:0005886,GO:0008360,GO:0007049 Rv0017c Rv0017c AL450380.2 Mycobrowser_v4 CDS 1157284 1157913 . + 0 ML0990 ML0990 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML0990, len: 209 aa. Probable conserved transmembrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49834 (EMBL:U00019) (209 aa), Fasta scores: E(): 0, 100.0% identity in 209 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv2732c TR:O33237 (EMBL:Z98209) (204 aa), Fasta scores: E(): 0, 70.6% identity in 201 aa overlap. Contains possible membrane spanning hydrophobic domains. Q7AQB8 No cell wall and cell processes Q7AQB8 Rv2732c Rv2732c AL450380.2 Mycobrowser_v4 CDS 386630 388933 . + 0 ML0304 pknG Involved in signal transduction (via phosphorylation). Thought to regulate amino-acid uptake and stationary-phase metabolism. Phosphorylates the peptide substrate myelin basic protein (MBP) at serine residues [Catalytic activity: ATP + A protein = ADP + A phosphoprotein]. Probable serine-threonine protein kinase PknG (protein kinase G) (STPK G) ML0304, len: 767 aa. Probable pknG, serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to Rv0410c|P96256|AL123456 pknG, serine/threonine protein kinase from M. tuberculosis (750 aa), Fasta scores: E(): 0, (83.1% identity in 756 aa overlap). Similar to many bacterial putative serine/threonine protein kinases e.g. CAB71204|AL138538 possible protein kinase from Streptomyces coelicolor (903 aa), Fasta scores: E(): 0, (42.0% identity in 793 aa overlap). Similar in part, to protein kinases from Myxococcus xanthus e.g. Q9XBP5|AF159692 pkn12, serine/threonine protein kinase (465 aa), Fasta scores: E(): 2.9e-10, (28.4% identity in 292 aa overlap). Previously sequenced as Q9ZBL8|AL035159) (763 aa), Fasta scores: E(): 0, (100.0% identity in 763 aa overlap). Also similar to regions of ML0016 and ML0017 from M.leprae. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature. Belongs to the Ser/Thr family of protein kinases. P57993 No regulatory proteins PF00069 P57993 GO:0006468,GO:0004674,GO:0005524 2.7.11.1 Rv0410c Rv0410c AL450380.2 Mycobrowser_v4 CDS 397047 397949 . - 0 ML0310c pssA Probable CDP-diacylglycerol-serine o-phosphatidyltransferase PssA (Phosphatidylserine synthase) (PS synthase) ML0310c, len: 300 aa. Probable pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (EC 2.7.8.8) (see citation below), integral membrane protein, highly similar to Rv0436c|PSS_MYCTU|P96282 pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) from M. tuberculosis (286 aa), Fasta scores: E(): 0, (77.9% identity in 285 aa overlap). Similar to many others e.g. PSS_HELPY|Q48269 pssA, CDP-diacylglycerol-serine o-phosphatidyltransferase from Helicobacter pylori (237 aa), Fasta scores: E(): 2.3e-14, (34.6% identity in 234 aa overlap). Previously sequenced as Q9ZBM2|AL035159 (300 aa), Fasta scores: E(): 0, (100.0% identity in 300 aa overlap). Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Q9ZBM2 No lipid metabolism PF01066 Q9ZBM2 GO:0003882,GO:0016021,GO:0008654,GO:0005886,GO:0046341 2.7.8.8 Rv0436c Rv0436c AL450380.2 Mycobrowser_v4 CDS 550194 551117 . - 0 ML0450c snzP Possible pyridoxine biosynthesis protein SnzP ML0450c, len: 307 aa. Possible snzP, pyridoxine biosynthesis protein. Highly similar to Rv2606c|YQ06_MYCTU|O06208 snzP, pyridoxine biosynthesis protein from M. tuberculosis (299 aa), Fasta scores: E(): 0, (89.7% identity in 291 aa overlap). Highly conserved in both bacteria and eukaryotes. Highly similar to several pyridoxine biosynthesis proteins and hypothetical proteins e.g. Q9UW83|AF133101 pyroA, pyridoxine biosynthesis protein from Emericella nidulans (304 aa), Fasta scores: E(): 0, (65.9% identity in 299 aa overlap); and SCL2.13c conserved hypothetical protein from Streptomyces coelicolor A3(2) (303 aa). Previously sequenced as YQ06_MYCLE|O07145 (333 aa), Fasta scores: E(): 0, (100.0% identity in 307 aa overlap). Contains Pfam match to entry PF01680, SOR_SNZ family. Contains PS01235 Uncharacterized protein family UPF0019 signature. Belongs to the SOR_SNZ family. O07145 No intermediary metabolism and respiration PF01680 O07145 GO:0042823,GO:0016829 4.-.-.- Rv2606c Rv2606c AL450380.2 Mycobrowser_v4 CDS 411593 412069 . + 0 ML0322 ispF Involved in the terpenoid biosynthesis pathway (at the fifth step). Converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. Also converts 4-diphosphocytidyl-2C-methyl-D-erythritol into 2C-methyl-D-erythritol 3,4-cyclophosphate and CMP [Catalytic activity: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP]. Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) ML0322, len: 158 aa. Probable ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12), highly similar to Rv3581c|YZ81_MYCTU|P96863 probable ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from M. tuberculosis (159 aa), Fasta scores: E(): 0, (79.1% identity in 158 aa overlap). Similar to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthases, e.g. Escherichia coli 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, BAA95145|AB038256 (159 aa), Fasta scores: E(): 1e-17, (41.3% identity in 155 aa overlap). Contains the PS01350 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature and Pfam match to entry PF02542 YgbB, putative enzyme of deoxy-xylulose pathway. Belongs to the IspF family. Q9CCW5 No intermediary metabolism and respiration PF02542 Q9CCW5 GO:0046872,GO:0016114,GO:0008685 4.6.1.12 Rv3581c Rv3581c AL450380.2 Mycobrowser_v4 CDS 425728 426555 . - 0 ML0336c ML0336c Probable conserved ATP-binding protein ABC transporter ML0336c, len: 275 aa. Probable conserved ATP-binding protein ABC transporter. Similar to many putative ABC-tranporter ATP-binding proteins e.g. O87477|EMBL:AF077010 troB, ABC transporter ATPase from Chlamydia trachomatis (286 aa), Fasta scores: E(): 4.7e-16, 31.4% identity in 223 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS) Q9CCW0 No cell wall and cell processes PF00005 Q9CCW0 GO:0016887,GO:0005524 AL450380.2 Mycobrowser_v4 CDS 426564 427472 . - 0 ML0337c ML0337c Possible ABC transporter periplasmic binding protein ML0337c, len: 302 aa. Possible periplasmic solute-binding protein. Similar but shorter than Rv2059|O07257 Conserved hypothetical protein (511 aa), fasta scores: E(): 2.6e-60 (61.132% identity in 265 aa overlap). Shows weak similarity to periplasmic solute-binding proteins e.g. Q55280|L34630 mntC, periplasmic-binding protein from Synechocystis sp. (strain PCC 6803) (330 aa), Fasta scores: E(): 0.0001, 26.4% identity in 178 aa overlap. Contains Pfam match to entry PF01297 Lipoprotein_4, Adhesion lipoprotein. Contains PS50893 ABC_TRANSPORTER_2 ATP-binding cassette and ABC transporter-type domain, PS00017 ATP_GTP_A ATP/GTP-binding site motif A. Belongs to the Periplasmic solute binding protein family. Q9CCV9 No cell wall and cell processes PF01297 Q9CCV9 GO:0030001,GO:0046872 AL450380.2 Mycobrowser_v4 CDS 461186 461542 . - 0 ML0369c ML0369c Conserved hypothetical protein ML0369c, len: 118 aa. Conserved hypothetical unknown protein. Some similarity, in part, to putative oxidoreductase from Streptomyces coelicolor A3(2) (341 aa), Fasta scores: E(): 0, (43.7% identity in 55 aa overlap). Previously sequenced as Q49877|U00020 (118 aa), Fasta scores: E(): 0, (100.0% identity in 118 aa overlap). Q49877 No conserved hypotheticals Q49877 AL450380.2 Mycobrowser_v4 CDS 462980 464857 . + 0 ML0371 glmS Probable glucosamine-fructose-6-phosphate aminotransferase GlmS (Hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (Glucosamine-6-phosphate synthase) ML0371, len: 625 aa. Probable glmS, glucosamine--fructose-6-phosphate aminotransferase (EC 2.6.1.16), highly similar to Rv3436c|GLMS_MYCTU|O06253 probable glmS, glucosamine-fructose-6-phosphate aminotransferase from M. tuberculosis (623 aa), Fasta scores: E(): 0, (89.3% identity in 627 aa overlap). Similar to many others e.g. O68956|GLMS_MYCSM from Mycobacterium smegmatis (627 aa), Fasta scores: E(): 0, (84.9% identity in 630 aa overlap); O86781|GLMS_STRCO|SC6G4.18 from Streptomyces coelicolor (614 aa), Fasta scores: E(): 0, (63.3% identity in 626 aa overlap). Also similar to ML0689c a possible pseudogene similar to M. tuberculosis glmS. Previously sequenced as GLMS_MYCLE|P40831 (624 aa), Fasta scores: E(): 0, (99.7% identity in 624 aa overlap). Contains Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains 2 Pfam matches to entry PF01380 SIS, SIS domain. Belongs to the type-2 gatase domain in the N-terminal section. Belongs to the SIS family, GLMS subfamily, in the C-terminal section. P40831 No intermediary metabolism and respiration PF00310,PF01380 P40831 GO:0005737,GO:0006541,GO:0004360,GO:0005529,GO:0016051 2.6.1.16 Rv3436c Rv3436c AL450380.2 Mycobrowser_v4 CDS 461946 462815 . - 0 ML0370c ML0370c Conserved hypothetical protein ML0370c, len: 289 aa. Conserved hypothetical protein, highly similar to Rv3438|O06255|AL123456 conserved hypothetical protein from M. tuberculosis (280 aa), Fasta scores: E(): 0, (80.6% identity in 279 aa overlap). Previously sequenced as Q49872|U00020 (324 aa), Fasta scores: E(): 0, (100.0% identity in 289 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature. Q9CCV6 No conserved hypotheticals Q9CCV6 Rv3438 Rv3438 AL450380.2 Mycobrowser_v4 CDS 480662 482251 . + 0 ML0387 guaB2 Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) ML0387, len: 529 aa. Probable guaB2, inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), highly similar to Rv3411c|IMDH_MYCTU|Q50715 guaB2, probable inosine-5'-monophosphate dehydrogenase from M. tuberculosis (529 aa), Fasta scores: E(): 0, (92.4% identity in 529 aa overlap). Similar to many others e.g. IMDH_ECOLI|P06981 guaB, inosine-5'-monophosphate dehydrogenase from Escherichia coli (488 aa), Fasta scores: E(): 0, (54.3% identity in 490 aa overlap). Previously sequenced as IMDH_MYCLE|Q49729 (529 aa), Fasta scores: E(): 0, (100.0% identity in 529 aa overlap). Also similar to ML2066 and shows weaker similarity to ML0388 from M. leprae. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus. Similar to other eukaryotic and prokaryotic IMPDH and to GMP reductase. Q49729 No intermediary metabolism and respiration PF00478,PF00571 Q49729 GO:0003938,GO:0055114,GO:0030955,GO:0006177 1.1.1.205 Rv3411c Rv3411c AL450380.2 Mycobrowser_v4 CDS 482275 483387 . + 0 ML0388 guaB3 Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (IMP oxidoreductase) (IMPD) (IMPDH) ML0388, len: 370 aa. Probable guaB3, inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), equivalent to Rv3410c|YY10_MYCTU|Q50716 guaB3, probable inosine-5'-monophosphate dehydrogenase from M. tuberculosis (375 aa), Fasta scores: E(): 0, (90.5% identity in 368 aa overlap). This ORF is similar in part to ML0387 and ML2066 from M. leprae, which more closely resemble the experimentally characterised IMP-DH's (e.g. from Escherichia coli). This shorter homologue is conserved in several bacterial genera e.g Q9L0I6 putative inosine-5'-monophosphate dehydrogenase from Streptomyces coelicolor A3(2) (374 aa), Fasta scores: E(): 0, (52.2% identity in 368 aa overlap). Previously sequenced as YY10_MYCLE|U00015 (375 aa), Fasta scores: E(): 0, (100.0% identity in 370 aa overlap). Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Similar to other eukaryotic and prokaryotic IMPDH and to GMP reductase. Q49721 No intermediary metabolism and respiration PF00478 Q49721 GO:0016491,GO:0055114 1.-.-.- Rv3410c Rv3410c AL450380.2 Mycobrowser_v4 CDS 511985 513274 . - 0 ML0414c otsB2 Involved in osmoregulatory trehalose biosynthesis. Mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [Catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]. Possible trehalose-6-phosphate phosphatase OtsB2 (Trehalose-phosphatase) (TPP) ML0414c, len: 429 aa. Possible otsB2, trehalose-6-phosphate phosphatase (EC 3.1.3.12), highly similar to Rv3372|O50401|AL123456 otsB2, trehalose-6-phosphate phosphatase from M. tuberculosis (391 aa), Fasta scores: E(): 0, (67.1% identity in 425 aa overlap). Also weakly similar to several trehalose phosphatases e.g. except at N-terminus, to O64897|AF007779 tppB, trehalose-6-phosphate phosphatase from Arabidopsis thaliana (374 aa), Fasta scores: E(): 2.2e-17, (31.1% identity in 315 aa overlap). Previously sequenced as Q49734|U00015 (429 aa), Fasta scores: E(): 0, (100.0% identity in 429 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Q49734 No virulence, detoxification, adaptation PF02358 Q49734 GO:0004805,GO:0005992 3.1.3.12 Rv3372 Rv3372 AL450380.2 Mycobrowser_v4 CDS 524930 526144 . + 0 ML0426 lppS Probable conserved lipoprotein LppS ML0426, len: 404 aa. Probable lppS, conserved lipoprotein, highly similar to Rv2518c|O53223|AL021185 probable lppS, lipoprotein from M. tuberculosis (408 aa), Fasta scores: E(): 0, (82.6% identity in 403 aa overlap). Does not contain a predicted membrane lipoprotein lipid attachment site (present in lppS), but does contain a possible N-terminal signal sequence. Similar to many predicted lipoproteins from Streptomyces coelicolor e.g. Q9X811|SC6G10.26c putative secreted protein from Streptomyces coelicolor (424 aa). Also similar to ML0569, ML2446 and ML2664 from M. leprae. Previously sequenced as O07707|Z97179 (407 aa), Fasta scores: E(): 0, (100.0% identity in 404 aa overlap). Q9CCU5 No cell wall and cell processes PF03734 Q9CCU5 Rv2518c Rv2518c AL450380.2 Mycobrowser_v4 CDS 553375 554337 . - 0 ML0453c ML0453c Probable acyltransferase ML0453c, len: 320 aa. Probable acyltransferase (EC 2.3.1.-), highly similar to Rv2611c|O06203|AL123456 probable acyltransferase from M. tuberculosis (316 aa), Fasta scores: E(): 0, (71.5% identity in 312 aa overlap); and Q9F7Y8 putative acyltransferase from Mycobacterium smegmatis (303 aa), Fasta scores: E(): 0, (67.8% identity in 301 aa overlap). Also similar to other acyltransferases e.g. Q9L283|SCL2.16c putative acyltransferase from Streptomyces coelicolor (311 aa), Fasta scores: E(): 7.4e-48 (48.0% identity in 302 aa overlap); and AAF31766|AF130984 lipid A biosynthesis acyltransferase from Campylobacter jejuni (295 aa), Fasta scores: E(): 0.00017, (20.0% identity in 180 aa overlap). Previously sequenced as O07148|Z96801 (320 aa), Fasta scores: E(): 0, (99.7% identity in 320 aa overlap). Q7AQJ0 No lipid metabolism PF03279 Q7AQJ0 GO:0016021,GO:0009244,GO:0008415 Rv2611c Rv2611c AL450380.2 Mycobrowser_v4 CDS 576362 577117 . + 0 ML0475 ML0475 Conserved hypothetical protein ML0475, len: 251 aa. Conserved hypothetical protein, highly similar to YQ03_MYCTU|O33214|Rv2603c Conserved hypothetical protein from M. tuberculosis (251 aa), Fasta scores: E(): 0, (92.4% identity in 251 aa overlap). Similar to many bacterial hypothetical proteins e.g. Q9L288|SCL2.11c HYPOTHETICAL 26.8 KDA PROTEIN from Streptomyces coelicolor (250 aa), FASTA scores: E(): 2.6e-73, (75.502% identity in 249 aa overlap); and Q9AE12|YFCA HYPOTHETICAL STRUCTURAL PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (251 aa), faasta scores: E(): 5.6e-70, (71.315% identity in 251 aa overlap). Previously sequenced as YQ03_MYCLE|Q49645 (251 aa), Fasta scores: E(): 0, (100.0% identity in 251 aa overlap). Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. Q49645 No conserved hypotheticals PF01709 Q49645 Rv2603c Rv2603c AL450380.2 Mycobrowser_v4 CDS 667999 668823 . - 0 ML0551c ML0551c Putative methyltransferase ML0551c, len: 274 aa. Putative methyltransferase, highly similar to YE05_MYCTU|P71673|Rv1405c Putative methyltransferase from M. tuberculosis (274 aa), Fasta scores: E(): 0, (78.0% identity in 273 aa overlap). Shows weak similarity to other methyltransferses e.g. PMTA_RHOSH|Q05197 pmtA, phosphatidylethanolamine N-methyltransferase from Rhodobacter sphaeroides (203 aa), Fasta scores: E(): 7.9e-08, (31.3% identity in 144 aa overlap) and UBIE_ECOLI|P27851 ubiE, ubiquinone/menaquinone biosynthesis methyltransferase from Escherichia coli (251 aa), Fasta scores: E(): 9.1e-06, (28.0% identity in 118 aa overlap). Q9CCQ1 No intermediary metabolism and respiration PF08241 Q9CCQ1 GO:0008168,GO:0008152 Rv1405c Rv1405c AL450380.2 Mycobrowser_v4 CDS 555663 557771 . - 0 ML0456c thrS Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) ML0456c, len: 702 aa. Probable thrS, threonyl-tRNA synthetase (Threonine--tRNA ligase) (EC 6.1.1.3), highly similar to Rv2614c|SYT_MYCTU|O06200 thrS, threonyl-tRNA synthetase from M. tuberculosis (692 aa), Fasta scores: E(): 0, (84.0% identity in 702 aa overlap). Similar to many e.g. SYT_THETH|P56881 from Thermus aquaticus (659 aa), Fasta scores: E(): 0, (45.0% identity in 645 aa overlap); P00955|SYT_ECOLI from Escherichia coli (642 aa). Previously sequenced as SYT_MYCLE|O07151 (702 aa), Fasta scores: E(): 0, (100.0% identity in 702 aa overlap). Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to the class-II aminoacyl-tRNA synthetase family. Cofactor: Binds 1 zinc ion. O07151 No information pathways PF00587,PF03129,PF07973 O07151 GO:0005737,GO:0004829,GO:0006435,GO:0008270,GO:0005524 6.1.1.3 Rv2614c Rv2614c AL450380.2 Mycobrowser_v4 CDS 581788 582399 . + 0 ML0482 ruvA FORMS A COMPLEX WITH RUVB. RUVA STIMULATES, IN THE PRESENCE OF DNA, THE WEAK ATPASE ACTIVITY OF RUVB. THE RUVA-RUVB COMPLEX IN THE PRESENCE OF ATP RENATURES CRUCIFORM STRUCTURE IN SUPERCOILED DNA WITH PALINDROMIC SEQUENCE, INDICATING THAT IT MAY PROMOTE STRAND EXCHANGE REACTIONS IN HOMOLOGOUS RECOMBINATION. RUVAB IS AN HELICASE THAT MEDIATES THE HOLLIDAY JUNCTION MIGRATION BY LOCALIZED DENATURATION AND REANNELING. Probable Holliday junction DNA helicase component RuvA ML0482, len: 203 aa. Probable ruvA, Holliday junction binding protein (see citations below), highly similar to Rv2593c|RUVA_MYCTU|Q50628 ruvA, Holliday junction DNA helicase from M. tuberculosis (196 aa), Fasta scores: E(): 0, (76.4% identity in 203 aa overlap). Also highly similar to others e.g. Q9L290|RUVA from Streptomyces coelicolor (201 aa), FASTA scores:E(): 3.7e-29,(47.500% identity in 200 aa overlap); and Q9AE10|RUVA from Corynebacterium glutamicum (Brevibacterium flavum) (206 aa), fasta scores: E(): 1.6e-26, (44.762% identity in 210 aa overlap). Previously sequenced as RUVA_MYCLE|P40832 (203 aa), Fasta scores: E(): 0, (99.5% identity in 203 aa overlap). Contains Pfam match to entry PF01330 RuvA, Bacterial DNA recombination protein, RuvA. Belongs to the ruvA family. P40832 No information pathways 1BVS PF01330,PF07499 P40832 GO:0003677,GO:0006310,GO:0006281,GO:0009379,GO:0009432,GO:0009378,GO:0005524 3.6.1.- Rv2593c Rv2593c AL450380.2 Mycobrowser_v4 CDS 582396 583445 . + 0 ML0483 ruvB FORMS A COMPLEX WITH RUVA. RUVB COULD POSSESS WEAK ATPASE ACTIVITY, WHICH WILL BE STIMULATED BY THE RUVA PROTEIN IN THE PRESENCE OF DNA. THE RUVA-RUVB COMPLEX IN THE PRESENCE OF ATP RENATURES CRUCIFORM STRUCTURE IN SUPERCOILED DNA WITH PALINDROMIC SEQUENCE, INDICATING THAT IT MAY PROMOTE STRAND EXCHANGE REACTIONS IN HOMOLOGOUS RECOMBINATION. RUVAB IS AN HELICASE THAT MEDIATES THE HOLLIDAY JUNCTION MIGRATION BY LOCALIZED DENATURATION AND REANNELING. Holliday junction binding protein RuvB ML0483, len: 349 aa. Probable ruvB, Holliday junction binding protein (EC 3.6.1.-) (see Mizrahi & Andersen 1998), highly similar to Rv2592c|RUVB_MYCTU|Q50629 ruvB, Holliday junction binding protein from M. tuberculosis (344 aa), Fasta scores: E(): 0, (94.4% identity in 342 aa overlap). Also highly similar to others e.g. Q9AE09|RUVB from Corynebacterium glutamicum (Brevibacterium flavum) (363 aa), E(): 7.2e-94, (74.850% identity in 334 aa overlap); and Q9L291|RUVB from Streptomyces coelicolor (357 aa), FASTA scores: E(): 8.1e-86, (66.859% identity in 347 aa overlap). Previously sequenced as RUVB_MYCLE|P40833 (369 aa), Fasta scores: E(): 0, (100.0% identity in 322 aa overlap). Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ruvB family. P40833 No information pathways PF00004,PF05491,PF05496 P40833 GO:0003677,GO:0006310,GO:0006281,GO:0009432,GO:0009378,GO:0005524 3.6.1.- Rv2592c Rv2592c AL450380.2 Mycobrowser_v4 CDS 591835 593250 . + 0 ML0488 secF Probable protein-export membrane protein SecF ML0488, len: 471 aa. Probable secF, protein-export membrane protein (integral membrane protein) (see citation below), highly similar to SECF_MYCTU|Q50635|Rv2586c secF, putative protein-export membrane protein from M. tuberculosis (442 aa), Fasta scores: E(): 0, (72.1% identity in 456 aa overlap); and CAD94802|Mb2617c from M. bovis (442 aa). Similar to others e.g. Q9AE06|SECF from Corynebacterium glutamicum (Brevibacterium flavum) (403 aa), FASTA scores: E(): 1.8e-67, (46.024% identity in 415 aa overlap); and Q53956|SECF_STRCO|SCL2.05c from Streptomyces coelicolor (373 aa), FASTA scores: E(): 3e-33, (35.941% identity in 409 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Belongs to the secD/secF family, secF family. Part of the prokaryotic protein translocation apparatus which comprises SecA1|ML0799, SecA2|ML2082c, SecD|ML0487, secG|ML0577, SecE|ML1907, SecF|ML0488 and SecY|ML1833. P38386 No cell wall and cell processes PF02355,PF07549 P38386 GO:0015450,GO:0016021,GO:0065002,GO:0005886,GO:0015628,GO:0015627,GO:0009276 Rv2586c Rv2586c AL450380.2 Mycobrowser_v4 CDS 2403496 2404458 . + 0 ML2011 aao PROBABLE D-AMINO ACID OXIDASE AAO ML2011, len: 320 aa. Probable aao, D-amino acid oxidase (EC 1.4.3.3). Similar to M. tuberculosis putative D-amino acid oxidase aao Rv1905c TR:O07727 (EMBL:Z97193) (320 aa), Fasta scores: E(): 0, 71.4% identity in 318 aa overlap, and to many others e.g. Bos taurus D-aspartate oxidase SW:OXDD_BOVIN (X95310) (341 aa), Fasta scores: E(): 7e-24, 30.2% identity in 328 aa overlap. Contains Pfam match to entry PF01266 DAO, D-amino acid oxidase. Q9RIA4 No intermediary metabolism and respiration PF01266 Q9RIA4 GO:0008152,GO:0016491,GO:0005488 Rv1905c Rv1905c AL450380.2 Mycobrowser_v4 CDS 619667 621088 . + 0 ML0510 ML0510 Conserved hypothetical protein ML0510, len: 473 aa. Conserved hypothetical protein, highly similar to YP59_MYCT|Q50739|Rv2559c conserved hypothetical ala-, leu-, val-rich protein from M. tuberculosis (452 aa), Fasta scores: E(): 0, (83.4% identity in 452 aa overlap); and CAD94774|Mb2589c from M. bovis (452 aa). Similar to other proteins in bacteria and eukaryotes e.g. Q8NQ21 Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase from Corynebacterium glutamicum (Brevibacterium flavum) (459 aa), fasta scores: E(): 1.5e-100, (62.690% identity in 461 aa overlap); and Q9KXP4|SC9C5.30c conserved ATP/GTP binding protein from Streptomyces coelicolor (451 aa), FASTA scores: E(): 3.7e-91, (61.574% identity in 432 aa overlap). Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CCT1 No conserved hypotheticals PF00004 Q9CCT1 GO:0017111,GO:0005524 Rv2559c Rv2559c AL450380.2 Mycobrowser_v4 CDS 631180 631788 . - 0 ML0520c ML0520c Probable conserved transmembrane protein ML0520c, len: 202 aa. Probable conserved transmembrane protein, highly similar to P95017|AL123456|Rv2536 Possible membrane protein from M. tuberculosis (230 aa), Fasta scores: E(): 2.6e-45, (63.2% identity in 201 aa overlap); and CAD94750|Mb2565 from M. bovis (230 aa). Contains hydrophobic, possible membrane-spanning regions. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CCS2 No cell wall and cell processes Q9CCS2 Rv2536 Rv2536 AL450380.2 Mycobrowser_v4 CDS 633534 634106 . + 0 ML0523 nusB N utilization substance protein NusB (NusB protein) ML0523, len: 190 aa. nusB, N utilization substance protein, highly similar but longer to NUSB_MYCTU|P95020|Rv2533c nusB, putative transcription termination protein from M. tuberculosis (156 aa), Fasta scores: E(): 1e-43, (75.7% identity in 148 aa overlap); CAD94747|Mb2562c from M. bovis (156 aa). Also similar to many e.g. P54520|NUSB_BACSU from Bacillus subtilis (131 aa), FASTA scores: E(): 6.3e-15, (41.860% identity in 129 aa overlap); and NUSB_ECOLI|P04381 nusB, N utilization substance protein B from Escherichia coli (139 aa), Fasta scores: E(): 7.4e-08, (38.1% identity in 139 aa overlap). Contains Pfam match to entry PF01029 NusB, NusB family. Belongs to the NusB family. Q9CCR9 No information pathways PF01029 Q9CCR9 GO:0006355,GO:0006353,GO:0003715,GO:0003723 Rv2533c Rv2533c AL450380.2 Mycobrowser_v4 CDS 645582 646547 . + 0 ML0532 pyrB Probable aspartate carbamoyltransferase PyrB (Aspartate transcarbamylase) (ATCase) ML0532, len: 321 aa. Probable pyrB, aspartate carbamoyltransferase (EC 2.1.3.2), highly similar to PYRB_MYCTU|P71808|Rv1380 pyrB, aspartate carbamoyltransferase from M. tuberculosis (319 aa), Fasta scores: E(): 0, (89.9% identity in 318 aa overlap); and CAD94276|Mb1415 from M. bovis (319 aa). Similar to many e.g. PYRB_STRCO|Q9KXR2 Aspartate carbamoyltransferase from Streptomyces coelicolor (326 aa), fasta scores: E(): 3.8e-74, (60.559% identity in 322 aa overlap); and PYRB_PSEPU|Q59711 aspartate carbamoyltransferase from Pseudomonas putida (334 aa), Fasta scores: (47.3% identity in 317 aa overlap). And weakly similarity to ML1410. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature. Belongs to the ATCases/OCTases family. Q9CCR5 No intermediary metabolism and respiration PF00185,PF02729 Q9CCR5 GO:0016597,GO:0006520,GO:0004070,GO:0006221,GO:0006207 2.1.3.2 Rv1380 Rv1380 AL450380.2 Mycobrowser_v4 CDS 657267 657899 . + 0 ML0541 gmk Probable guanylate kinase Gmk (GMP kinase). ML0541, len: 210 aa. Probable gmk, guanylate kinase (EC 2.7.4.8), highly similar to KGUA_MYCTU|P71659|Rv1389 gmk, putative guanylate kinase from M. tuberculosis (208 aa), Fasta scores: E(): 1.8e-62, (79.1% identity in 201 aa overlap). Similar to many e.g. Q9KXS0|KGUA_STRCO Guanylate kinase from Streptomyces coelicolor (197 aa), fasta scores: E(): 3e-31, (53.889% identity in 180 aa overlap). Contains Pfam match to entry PF00625 Guanylate_kin, Guanylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00856 Guanylate kinase signature. Belongs to the Guanylate kinase family. Q9CCQ7 No intermediary metabolism and respiration PF00625 Q9CCQ7 GO:0005737,GO:0004385,GO:0006163,GO:0005524 2.7.4.8 Rv1389 Rv1389 AL450380.2 Mycobrowser_v4 CDS 656896 657213 . + 0 ML0540 mihF Putative integration host factor MihF ML0540, len: 105 aa. Putative mihF, integration host factor, highly similar at the carboxy terminus to P71658|AL123456|Rv1388 mihF, possible integration host factor from M. tuberculosis (190 aa), Fasta scores: E(): 3.8e-35, (98.1% identity in 105 aa overlap) and CAD94284|Mb1423 from M. bovis (190 aa). And highly similar to P96802|U75344 mihF, integration host factor from Mycobacterium smegmatis (105 aa), Fasta scores: E(): 7.5e-32, (94.1% identity in 102 aa overlap). Q9CCQ8 No information pathways Q9CCQ8 Rv1388 Rv1388 AL450380.2 Mycobrowser_v4 CDS 652995 653843 . + 0 ML0537 pyrF Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) ML0537, len: 282 aa. Probable pyrF, orotidine 5'-phosphate decarboxylase (EC 4.1.1.23), highly similar to DCOP_MYCTU|P77898|Rv1385 pyrF, orotidine 5'-phosphate decarboxylase from M. tuberculosis (274 aa), Fasta scores: E(): 3e-78, (77.3% identity in 282 aa overlap); and CAD94281|Mb1420 from M. bovis (274 aa). Similar to many e.g. DCOP_MYCSM|O08323 pyrF, orotidine 5'-phosphate decarboxylase from Mycobacterium smegmatis (276 aa), Fasta scores: E(): 2.1e-70, (72.5% identity in 280 aa overlap). Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. Belongs to the OMP decarboxylase family. Q9CCR1 No intermediary metabolism and respiration PF00215 Q9CCR1 GO:0004590,GO:0006221,GO:0006207 4.1.1.23 Rv1385 Rv1385 AL450380.2 Mycobrowser_v4 CDS 654130 654438 . + 0 ML0538 PE4 PE-family protein ML0538, len: 102 aa. Member of the Mycobacteria PE family, highly similar to YD86_MYCTU|P71656|Rv1386 PE15, PE-family protein from M. tuberculosis (102 aa), Fasta scores: E(): 2.8e-25, (72.5% identity in 102 aa overlap); CAD94282|Mb1421 from M. bovis (102 aa). And similar to ML2534, ML1183 ML1053 and ML2129. Q9CCR0 No PE/PPE PF00934 Q9CCR0 Rv1386 Rv1386 AL450380.2 Mycobrowser_v4 CDS 674680 675396 . - 0 ML0557c lprG Probable conserved lipoprotein LprG ML0557c, len: 238 aa. Probable lprG, conserved lipoprotein, highly similar to LPRG_MYCTU|P71679|Rv1411c lprG, putative lipoprotein from M. tuberculosis (234 aa), Fasta scores: E(): 0, (68.1% identity in 238 aa overlap) and similar to other M. tuberculosis lipoproteins e.g. Rv1270c, Rv1368, Rv2945c. Also similar to CAD94307|Mb1446c from M. bovis (236 aa) and to ML0136 from M. leprae. Contains probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al., 2000). Q9CCP6 No cell wall and cell processes PF07161 Q9CCP6 GO:0005886 Rv1411c Rv1411c AL450380.2 Mycobrowser_v4 CDS 659722 660933 . + 0 ML0544 metK Involved in the activated Methyl cycle. Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. [CATALYTIC ACTIVITY : ATP + L-METHIONINE + H(2)O = PHOSPHATE + DIPHOSPHATE + S-ADENOSYL-L-METHIONINE] Probable S-adenosylmethionine synthase MetK (MAT) (AdoMet synthetase) (Methionine adenosyltransferase) ML0544, len: 403 aa. Probable metK, S-adenosylmethionine synthetase (EC 2.5.1.6), highly similar to METK_MYCTU|P77899|Rv1392 metK, putative S-adenosylmethionine synthase from M. tuberculosis (403 aa), Fasta scores: E(): 9.7e-149, (91.3% identity in 403 aa overlap); and CAD94288|Mb1427 from M. bovis (403 aa). Similar to others e.g. METK_STRST|Q9X4Q2 metK, S-adenosylmethionine synthase from Streptomyces spectabilis (411 aa), Fasta scores: E(): 2.3e-115, (73.6% identity in 398 aa overlap). Contains Pfam match to entry PF00438 S-AdoMet_synt, S-adenosylmethionine synthetase. Contains PS00377 S-adenosylmethionine synthetase signature 2. Contains PS00376 S-adenosylmethionine synthetase signature 1. Belongs to the AdoMet synthetase family. Q9CCQ4 No intermediary metabolism and respiration PF00438,PF02772,PF02773 Q9CCQ4 GO:0050897,GO:0005737,GO:0000287,GO:0004478,GO:0006730,GO:0030955,GO:0005524 2.5.1.6 Rv1392 Rv1392 AL450380.2 Mycobrowser_v4 CDS 667332 667817 . + 0 ML0550 ML0550 Probable transcriptional regulatory protein (MarR family) ML0550, len: 161 aa. Probable transcriptional regulatory protein, highly similar to P71672|AL123456|Rv1404 Probable transcriptional regulatory protein from M. tuberculosis (160 aa), Fasta scores: E(): 0, (79.1% identity in 158 aa overlap); and CAD94300|Mb1439 from M. bovis (160 aa). Shows similarity to other regulatory proteins, particular from the marR family e.g. Q9K446 Putative transcriptional regulator from Streptomyces coelicolor (158 aa), fasta scores: E(): 3.7e-25, (54.930% identity in 142 aa overlap). Contains Pfam match to entry PF01047 MarR, MarR family. Belongs to the MarR family of transcriptional regulators. Q9CCQ2 No regulatory proteins PF01047 Q9CCQ2 GO:0006355,GO:0003700,GO:0005622 Rv1404 Rv1404 AL450380.2 Mycobrowser_v4 CDS 671417 672091 . + 0 ML0554 rpe Probable ribulose-phosphate 3-epimerase Rpe ML0554, len: 224 aa. Probable rpe, ribulose-phosphate 3-epimerase (EC 5.1.3.1), highly similar to RPE_MYCTU|P71676|Rv1408 rpe, ribulose-phosphate 3-epimerase from M. tuberculosis (232 aa), Fasta scores: E(): 0, (91.0% identity in 221 aa overlap); and CAD94304|Mb1443 from M. bovis (232 aa). Similar to many e.g. Q9L0Z5|RPE_STRCO Ribulose-phosphate 3-epimerase from Streptomyces coelicolor (228 aa), E(): 3.8e-54, (60.731% identity in 219 aa overlap). Contains Pfam match to entry PF00834 Ribul_P_3_epim, Ribulose-phosphate 3 epimerase family. Contains PS01085 Ribulose-phosphate 3-epimerase family signature 1. Contains PS01086 Ribulose-phosphate 3-epimerase family signature 2. Belongs to the Ribulose-phosphate 3-epimerase family Q9CCP9 No intermediary metabolism and respiration PF00834 Q9CCP9 GO:0004750,GO:0005975 5.1.3.1 Rv1408 Rv1408 AL450380.2 Mycobrowser_v4 CDS 686814 687407 . + 0 ML0568 ML0568 Possible conserved secreted protein ML0568, len: 197 aa. Possible secreted protein (see citation below) with a N-terminal signal sequence, similar to O06823|AL123456|Rv1435c Probable conserved Pro-, Gly-, Val-rich secreted protein from M. tuberculosis (202 aa), Fasta scores: E(): 1.7e-07, (38.9% identity in 203 aa overlap); and CAD94331|Mb1470c from M. bovis (209 aa). Pro- and Val-rich protein. Q9CCN7 No cell wall and cell processes Q9CCN7 AL450380.2 Mycobrowser_v4 CDS 675553 676176 . + 0 ML0558 ribC INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN SYNTHASE IS A BIFUNCTIONAL ENZYME COMPLEX CATALYZING THE FORMATION OF RIBOFLAVIN FROM 5-AMINO-6-(1'-D)- RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE AND L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA 6,7-DIMETHYL-8-LUMAZINE. THE ALPHA SUBUNIT CATALYZES THE DISMUTATION OF 6,7-DIMETHYL-8-LUMAZINE TO RIBOFLAVIN AND 5-AMINO-6-(1'-D)-RIBITYL-AMINO-2,4(1H,3H)- PYRIMIDINEDIONE. Probable riboflavin synthase [alpha] chain RibC (RibE) ML0558, len: 207 aa. Probable ribC (ribE), Riboflavin synthase alpha chain (EC 2.5.1.9), highly similar to RISA_MYCTU|P71680|Rv1412 ribC, riboflavin synthase [alpha] chain from M. tuberculosis (201 aa), Fasta scores: E(): 7.1e-66, (82.4% identity in 199 aa overlap); and CAD94308|Mb1447 from M. bovis (201 aa). Similar to many e.g. RISA_BACSU|P16440 ribE, riboflavin synthase alpha chain from Bacillus subtilis (215 aa), Fasta scores: E(): 9.5e-28, (43.4% identity in 198 aa overlap). Contains 2 Pfam matches to entry PF00677 Lum_binding, Lumazine binding domain. Contains 2 x PS00693 Riboflavin synthase alpha chain family signature. Q9CCP5 No intermediary metabolism and respiration PF00677 Q9CCP5 GO:0004746 2.5.1.9 Rv1412 Rv1412 AL450380.2 Mycobrowser_v4 CDS 677607 678089 . + 0 ML0560 ribH RIBOFLAVIN SYNTHASE IS A BIFUNCTIONAL ENZYME COMPLEX INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN SYNTHASE CATALYZES THE FORMATION OF RIBOFLAVIN FROM 5-AMINO-6-(1'-D)- RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE AND L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA 6,7-DIMETHYL-8-LUMAZINE. THE BETA SUBUNIT CATALYZES THE CONDENSATION OF 5-AMINO-6-(1'-D)-RIBITYL- AMINO-2,4(1H,3H)-PYRIMIDINEDIONE WITH L-3,4-DIHYDROHY-2-BUTANONE- 4-PHOSPHATE YIELDING 6,7-DIMETHYL-8-LUMAZINE. Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (Lumazine synthase). ML0560, len: 160 aa. Probable ribH, riboflavin synthase beta chain (EC 2.5.1.9), highly similar to RISB_MYCTU|P71685|Rv1416 ribH, riboflavin synthase [beta] chain from M. tuberculosis (154 aa), Fasta scores: E(): 0, (78.9% identity in 152 aa overlap); and CAD94312|Mb1451 from M. bovis (154 aa). Similar to many e.g. Q9EWJ9|RISB_STRCO 6,7-dimethyl-8-ribityllumazine synthase from Streptomyces coelicolor (161 aa), fasta scores: E(): 3.8e-30, (54.305% identity in 151 aa overlap). Contains Pfam match to entry PF00885 DMRL_synthase, 6,7-dimethyl-8-ribityllumazine synthase. Q9CCP3 No intermediary metabolism and respiration PF00885 Q9CCP3 GO:0004746,GO:0009349,GO:0009231 2.5.1.9 Rv1416 Rv1416 AL450380.2 Mycobrowser_v4 CDS 678871 680814 . + 0 ML0562 uvrC INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). ATTACHES TO THE UVRA-UVRB COMPLEX, DISPLACING UVRA, AND THE DAMAGED DNA STRAND IS NICKED ON BOTH SIDES OF THE DAMAGED SITE Probable excinuclease ABC (subunit C - nuclease) UvrC (UvrC protein) (Excinuclease ABC subunit C) ML0562, len: 647 aa. Probable uvrC, excinuclease ABC, subunit C (see citations below), highly similar to UVRC_MYCTU|P71689|Rv1420 uvrC, excinuclease ABC subunit C from M. tuberculosis (646 aa), Fasta scores: E(): 0, (87.6% identity in 646 aa overlap); and CAD94316|1455 from M. bovis (646 aa). Similar to many e.g. Q9Z512|UVRC_STRCO UvrABC system protein C (UvrC protein) from Streptomyces coelicolor (728 aa), fasta scores: E(): 1.4e-90, (57.803% identity in 692 aa overlap). Contains Pfam match to entry PF01541 Exci_endo_N, Endo/excinuclease amino terminal domain. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif. Belongs to the UrvC family. Q9CCP1 No information pathways PF00633,PF01541,PF02151,PF08459 Q9CCP1 GO:0009432,GO:0005737,GO:0009381,GO:0009380,GO:0006289,GO:0003677 Rv1420 Rv1420 AL450380.2 Mycobrowser_v4 CDS 699951 700184 . + 0 ML0577 secG Probable protein-export membrane protein (Translocase subunit) SecG ML0577, len: 77 aa. Probable secG, protein-export membrane protein (translocase subunit) (see citation below), highly similar to SECG_MYCTU|O06819|Rv1440 secG, probable protein-export membrane protein from M. tuberculosis (77 aa), Fasta scores: E(): 1.1e-25, (96.1% identity in 77 aa overlap); and CAD96142|Mb1475 from M. bovis (77 aa). Similar to many e.g. Q9Z521|SECG_STRCO Protein-export membrane protein from Streptomyces coelicolor (102 aa), fasta scores: E(): 3.9e-12, (53.425% identity in 73 aa overlap). Previously sequenced as SECG_MYCLE|P38388 (77 aa), Fasta scores: E(): 3.1e-26, (100.0% identity in 77 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Part of the prokaryotic protein translocation apparatus which comprises SecA1|ML0799, SecA2|ML2082c, SecD|ML0487, secG|ML0577, SecE|ML1907, SecF|ML0488 and SecY|ML1833. P38388 No cell wall and cell processes PF03840 P38388 GO:0016021,GO:0065002,GO:0005886,GO:0009306,GO:0015450 Rv1440 Rv1440 AL450380.2 Mycobrowser_v4 CDS 712669 713604 . - 0 ML0587c ML0587c Possible unidentified antibiotic-transport integral membrane protein ABC transporter ML0587c, len: 311 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), highly similar to O53148|AL123456|Rv1456c Possible unidentified antibiotic-transport integral membrane protein ABC transporter from M. tuberculosis (310 aa), Fasta scores: E(): 3.7e-95, (83.3% identity in 300 aa overlap); CAD96158|Mb1491c from M. bovis (310 aa). Similar to other bacterial hypothetical membrane proteins e.g. O87318|AF027770 fxtF, hypothetical protein from Mycobacterium smegmatis (236 aa), Fasta scores: E(): 1.3e-54, (67.5% identity in 228 aa overlap). Previously sequenced as O33142|Z99125 (311 aa), Fasta scores: E(): 0, (99.7% identity in 311 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQI1 No cell wall and cell processes PF02628 Q7AQI1 GO:0006461,GO:0016021 Rv1456c Rv1456c AL450380.2 Mycobrowser_v4 CDS 1331541 1332053 . + 0 ML1141 atpF PROBABLE ATP SYNTHASE B CHAIN ATPF ML1141, len: 170 aa. Probable atpF, ATP synthase B chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase B chain (EC 3.6.1.34) SW:ATPF_MYCLE (P45827) (170 aa), Fasta scores: E(): 0, 100.0% identity in 170 aa overlap. Also highly similar to many other proposed ATPase B chain family proteins e.g. Mycobacterium tuberculosis Rv1306 SW:ATPF_MYCTU (Q10596) (171 aa), Fasta scores: E(): 0, 79.5% identity in 171 aa overlap and Bacillus PS3 (Thermophilic bacterium PS-3) SW:ATPF_BACP3 (P09221) (163 aa), Fasta scores: E(): 0.00044, 22.5% identity in 142 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00430 ATP-synt_B, ATP synthase B/B' CF(0). P45827 No intermediary metabolism and respiration PF00430 P45827 GO:0046933,GO:0016021,GO:0005886,GO:0045263,GO:0015986 Rv1306 Rv1306 AL450380.2 Mycobrowser_v4 CDS 739212 740051 . + 0 ML0607 ML0607 Conserved hypothetical protein ML0607, len: 279 aa. Conserved hypothetical protein, highly similar to P71734|AL123456|Rv2409c conserved hypothetical protein from M. tuberculosis (279 aa), Fasta scores: E(): 2e-100, (82.1% identity in 279 aa overlap); and similar to YP69_MYCTU|Q50652|Rv2569c conserved hypothetical protein from M. tuberculosis (314 aa), Fasta scores: E(): 4.1e-13, (33.0% identity in 300 aa overlap). Similar to other bacterial hypothetical proteins e.g. Q9RSX6|AE002037|DR1993 conserved hypothetical protein from Deinococcus radiodurans (274 aa), Fasta scores: E(): 8.2e-25, (33.6% identity in 280 aa overlap). And similar to ML0508 from M. leprae. Previously sequenced as YP69_MYCLE|U00016 (279 aa), Fasta scores: E(): 0, (100.0% identity in 279 aa overlap). Contains Pfam match to entry PF01841 Transglut_core, Transglutaminase-like superfamily. Q49757 No conserved hypotheticals PF01841,PF08379 Q49757 Rv2409c Rv2409c AL450380.2 Mycobrowser_v4 CDS 715976 717757 . - 0 ML0591c ML0591c Possible conserved integral membrane protein ML0591c, len: 593 aa. Possible conserved integral membrane protein, highly similar to O53150|AL123456|Rv1459c Possible conserved integral membrane protein from M. tuberculosis (591 aa), Fasta scores: E(): 4.6e-90, (78.6% identity in 585 aa overlap); and CAD96161|Mb1494c from M. bovis (591 aa). Similar to other membrane proteins e.g. Q8FNS5 Putative integral membrane protein from Corynebacterium efficiens (521 aa), fasta scores: E(): 1.1e-23, (28.736% identity in 522 aa overlap). And similar to O53508|AL123456|Rv2174 from M. tuberculosis (516 aa) and ML0899 from M. leprae. Previously sequenced as Q49695|U00013 (593 aa), Fasta scores: E(): 0, (100.0% identity in 593 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q7AQH7 No cell wall and cell processes Q7AQH7 Rv1459c Rv1459c AL450380.2 Mycobrowser_v4 CDS 721295 722473 . + 0 ML0594 ML0594 Conserved hypothetical protein ML0594, len: 392 aa. Conserved hypothetical protein, highly similar to YE62_MYCTU|O53153|Rv1462 Conserved hypothetical protein from M. tuberculosis (397 aa), Fasta scores: E(): 1.4e-132, (80.4% identity in 392 aa overlap); and CAD96164|Mb1497 from M. bovis (397 aa). Similar to many bacterial hypothetical proteins e.g. Q9XAD2|AL096839|SCC22.06C conserved hypothetical protein from Streptomyces coelicolor (394 aa), Fasta scores: E(): 2.3e-87, (58.6% identity in 365 aa overlap). Previously sequenced as YE62_MYCLE|Q49682 (392 aa), Fasta scores: E(): 0, (100.0% identity in 392 aa overlap). And similar to the C-terminal half of ML0593. Contains Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051). Q49682 No conserved hypotheticals PF01458 Q49682 GO:0005515,GO:0016226 Rv1462 Rv1462 AL450380.2 Mycobrowser_v4 CDS 2324570 2325577 . - 0 ML1938c lytB2 PROBABLE LYTB-RELATED PROTEIN LYTB2 ML1938c, len: 335 aa. Probable LytB2-related protein. Similar to M. tuberculosis LytB protein homolog lytB2 Rv1110 SW:LYB1_MYCTU (O53458) (335 aa), Fasta scores: E(): 0, 82.9% identity in 333 aa overlap, and to many others e.g. Escherichia coli LytB protein SW:LYTB_ECOLI (P22565) (316 aa), Fasta scores: E(): 0, 51.5% identity in 309 aa overlap. Q9X781 No cell wall and cell processes PF02401 Q9X781 GO:0051745,GO:0005506,GO:0019288,GO:0055114,GO:0016114,GO:0051538 1.17.1.2 Rv1110 Rv1110 AL450380.2 Mycobrowser_v4 CDS 722470 723252 . + 0 ML0595 ML0595 Probable conserved ATP-binding protein ABC transporter ML0595, len: 260 aa. Probable conserved ATP-binding protein ABC transporter, highly similar to O53154|AL123456|Rv1463 conserved ATP-binding protein ABC transporter from M. tuberculosis (266 aa), Fasta scores: E(): 1.7e-81, (85.8% identity in 267 aa overlap); and CAD96165 from M. bovis (266 aa). Similar to many members of the ABC transporter family e.g. Q8NQ77 ABC-type transporter, ATPase component from Corynebacterium glutamicum (Brevibacterium flavum) (252 aa), fasta scores: E(): 3.1e-61, (65.873% identity in 252 aa overlap); and members found in chloroplast genomes e.g. ABCX_CYAPA|P48255 ycf16, probable ATP-dependent transporter from Cyanophora paradoxa (259 aa), Fasta scores: (54.2% identity in 227 aa overlap). Previously sequenced as Q49693|U00013 (260 aa), Fasta scores: E(): 0, (100.0% identity in 260 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters). Q7AQH5 No cell wall and cell processes PF00005 Q7AQH5 GO:0016887,GO:0006810,GO:0005524 Rv1463 Rv1463 AL450380.2 Mycobrowser_v4 CDS 736550 738235 . + 0 ML0605 ML0605 Conserved hypothetical protein ML0605, len: 561 aa. Conserved hypothetical protein, highly similar to YO11_MYCTU|P71732|Rv2411c conserved hypothetical protein from M. tuberculosis (551 aa), Fasta scores: E(): 1.4e-187, (87.4% identity in 554 aa overlap); and CAD97295|Mb2434c from M. bovis (551 aa). Similar to other bacterial hypothetical proteins. This CDS and the downstream CDS are also similar to the N- and C-terminal regions respectively, of longer hypothetical proteins from M. tuberculosis and M. leprae e.g. YP67_MYCTU|Q50654|Rv2567 from M. tuberculosis (884 aa), Fasta scores: (32.2% identity in 537 aa overlap); and ML2679 from M. lperae (894 aa). Contains a Gln-rich region at the C-terminus. Previously sequenced as YO11_MYCLE|Q49755 (561 aa), Fasta scores: E(): 0, (100.0% identity in 561 aa overlap). Q49755 No conserved hypotheticals PF04169,PF04174 Q49755 Rv2411c Rv2411c AL450380.2 Mycobrowser_v4 CDS 3009264 3010283 . - 0 ML2527c eccE3 ESX CONSERVED COMPONENT ECCE3. PROBABLE TRANSMEMBRANE PROTEIN. ML2527c, len: 339 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0292 TR:O53696 (EMBL:AL021930) fasta scores: E(): 0, 61.6% identity in 333 aa. Contains possible membrane spanning hydrophobic domains. Q9CD37 No cell wall and cell processes Q9CD37 Rv0292 Rv0292 AL450380.2 Mycobrowser_v4 CDS 748383 749429 . + 0 ML0615 subI Probable sulphate-binding lipoprotein SubI ML0615, len: 348 aa. Probable subI, sulfate-binding lipoprotein component of sulfate transport system (see citations below), highly similar to P71744|AL123456|Rv2400c subI, probable sulfate-binding lipoprotein from M. tuberculosis subI (356 aa), Fasta scores: E(): 1.6e-109, (76.5% identity in 340 aa overlap). Similar to many e.g. SUBI_ECOLI|P06997 sbp, sulfate-binding protein precursor from Escherichia coli (329 aa), Fasta scores: E(): 1.2e-28, (35.7% identity in 291 aa overlap). Previously sequenced as Q49748|U00016 (358 aa), Fasta scores: E(): 0, (100.0% identity in 348 aa overlap). Contains Pfam match to entry PF01100 Sulphate_bind, Prokaryotic sulphate- and thiosulphate-binding protein. Belongs to the prokaryotic sulfate binding protein family. Q9CCN3 No cell wall and cell processes PF01547 Q9CCN3 GO:0015419,GO:0008272,GO:0030288 Rv2400c Rv2400c AL450380.2 Mycobrowser_v4 CDS 757874 759010 . + 0 ML0625 dnaJ2 Probable chaperone protein DnaJ2 ML0625, len: 378 aa. Probable dnaJ2, chaperone protein, highly similar to O05825|AL123456|Rv2373c Probable dnaJ2, chaperone protein from M. tuberculosis (382 aa), Fasta scores: E(): 1.7e-138, (88.0% identity in 382 aa overlap); and CAD97255|Mb2394c from M. bovis (382 aa). Similar to many e.g. Q9RDD7|DNJ2_STRCO Chaperone protein dnaJ2 from Streptomyces coelicolor (378 aa), fasta scores: E(): 1.2e-83, (54.068% identity in 381 aa overlap); and DNAJ_ECOLI|P08622 dnaJ, Dna protein from Escherichia coli (375 aa), Fasta scores: (40.6% identity in 382 aa overlap). Also similar to ML2494. Previously sequenced as Q49762|U00016 (378 aa), Fasta scores: E(): 0, (99.7% identity in 378 aa overlap). Contains Pfam match to entry PF01556 DnaJ_C, DnaJ C terminal region. Contains Pfam match to entry PF00684 DnaJ_CXXCXGXG, DnaJ central domain (4 repeats). Contains Pfam match to entry PF00226 DnaJ, DnaJ domain. Belongs to the DNAJ family. Q49762 No virulence, detoxification, adaptation PF00226,PF00684,PF01556 Q49762 GO:0005737,GO:0031072,GO:0006457,GO:0006950,GO:0051082,GO:0008270,GO:0006260 Rv2373c Rv2373c AL450380.2 Mycobrowser_v4 CDS 765912 766718 . + 0 ML0633 recO Probable DNA repair protein RecO ML0633, len: 268 aa. Probable DNA repair protein recO (Recombination protein O), highly similar to O05836|AL123456|Rv2362c Probable DNA repair protein recO from M. tuberculosis (265 aa), Fasta scores: E(): 1.1e-98, (86.6% identity in 268 aa overlap); and CAD97244|Mb2383c from M. bovis. Similar to others e.g. Q9L2H3|RECO_STRCO DNA repair protein recO from Streptomyces coelicolor (251 aa), Fasta scores: E(): 9.6e-50, (52.8% identity in 248 aa overlap). Shows weak similarity, except at C-terminus to RECO_BACSU|P42095 recO, DNA repair protein from Bacillus subtilis (255 aa), Fasta scores: E(): 5.3e-11, (27.3% identity in 176 aa overlap). Previously sequenced as Q49754|U00016 (269 aa), Fasta scores: E(): 0, (100.0% identity in 268 aa overlap). Contain a Pfam match to PF02565; RecO. BELONGS TO THE RECO FAMILY. Q9CCN0 No information pathways PF02565 Q9CCN0 GO:0006281,GO:0006310 Rv2362c Rv2362c AL450380.2 Mycobrowser_v4 CDS 894550 895476 . + 0 ML0752 wbbL PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WbbL1 (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENYL) ML0752, len: 308 aa. Probable wbbL1, dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3-L-rhamnosyl transferase (EC 2.-.-.-) (see citations below), highly similar to Rv3265c|MTCY71.05c|P96870|Z92771 wbbL1, dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium tuberculosis (301 aa), fasta scores: E(): 3.4e-110, (84.7% identity in 301 aa), and to Q9RN50|AF187550 (see note * below) dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol from Mycobacterium smegmatis (296 aa), fasta scores: E(): 5.5e-89, (69.9% identity in 296 aa). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. [* Note: UNPUBLISHED (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme, dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A., Motichka K., Jucker M., Wu H.P., Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W., Pan F., Kimbrel S., Kundu M., McNeil M.]. Q9CCK7 No cell wall and cell processes PF00535 Q9CCK7 GO:0016740 Rv3265c Rv3265c AL450380.2 Mycobrowser_v4 CDS 854777 855691 . + 0 ML0715 lpqC Possible esterase lipoprotein LpqC ML0715, len: 304 aa. Possible lpqC, esterase lipoprotein (EC 3.1.-.-), highly similar to P96903|AL123456|Rv3298c Possible lpqC, esterase lipoprotein from M. tuberculosis (304 aa), Fasta scores: E(): 0, (72.0% identity in 300 aa overlap); and CAD95418|Mb3326c from M. bovis (304 aa). Shows weak similarity to hydrolases e.g. Q9Y871|AF164516 estA, cinnamoyl ester hydrolase from Piromyces equi (536 aa), Fasta scores: E(): 4.8e-12, (27.9% identity in 265 aa overlap) and PHA1_PSELE|P52090 phaZ1, secreted poly(3-hydroxyalkanoate) depolymerase C precursor from Pseudomonas lemoignei (414 aa), Fasta scores: E(): 2.5e-06, (25.6% identity in 320 aa overlap). Previously sequenced as Q49658|U00012 (302 aa), Fasta scores: E(): 0, (99.7% identity in 302 aa overlap). Contains a possible N-terminal signal sequence. Q9CCL5 No cell wall and cell processes Q9CCL5 GO:0016787 Rv3298c Rv3298c AL450380.2 Mycobrowser_v4 CDS 803527 804651 . + 0 ML0667 prfB Probable peptide chain release factor 2 PrfB (RF-2) ML0667, len: 374 aa. Probable prfB, peptide chain release factor 2, highly similar to RF2_MYCTU|O05782|Rv3105c prfB, peptide chain release factor 2 from M. tuberculosis (371 aa), Fasta scores: E(): 0, (90.1% identity in 372 aa overlap); and CAD96819|3132c from M. bovis (378 aa). Similar to many e.g. RF2_STRCO|Q53915 prfB, peptide chain release factor 2 from Streptomyces coelicolor (368 aa), Fasta scores: E(): 4.9e-99, (66.9% identity in 369 aa overlap). Also similar to ML1134. Previously sequenced as RF2_MYCLE|O32885 (374 aa), Fasta scores: E(): 0, (99.7% identity in 374 aa overlap). Contains Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain. Contains PS00745 Prokaryotic-type class I peptide chain release factors signature. BELONGS TO THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY. O32885 No information pathways PF00472,PF03462 O32885 GO:0016149,GO:0006415,GO:0005737 Rv3105c Rv3105c AL450380.2 Mycobrowser_v4 CDS 806611 807504 . + 0 ML0670 ftsX INVOLVED IN GROWTH (PRINCIPALLY DURING LOG PHASE CELLS). THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF SEPTATION COMPONENT ACROSS THE MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. IS CODED IN AN OPERON ESSENTIAL FOR CELL DIVISION. Putative cell division protein FtsX (SEPTATION COMPONENT-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER ML0670, len: 297 aa. Putative ftsX, cell division protein, septation component transport integral membrane protein ABC transporter, highly similar to FTSX_MYCTU|P96293|Rv3101c Putative ftsX, cell division protein, septation component transport integral membrane protein ABC transporter from M. tuberculosis (297 aa), Fasta scores: E(): 0, (80.8% identity in 297 aa overlap); and CAD96815|Mb3128c from M. bovis (297 aa). Similar to many e.g. FTSX_BACSU|O34876 ftsX, cell division protein ftsX homolog from Bacillus subtilis (296 aa), Fasta scores: E(): 1.5e-14, (25.8% identity in 302 aa overlap). Previously sequenced as FTSX_MYCLE|O32882 (287 aa), Fasta scores: E(): 0, (99.7% identity in 287 aa overlap). Contains hydrophobic, possible membrane-spanning regions. BELONGS TO THE FTSX FAMILY. O32882 No cell wall and cell processes PF02687 O32882 GO:0051301,GO:0016021,GO:0005886,GO:0007049 Rv3101c Rv3101c AL450380.2 Mycobrowser_v4 CDS 901764 902903 . - 0 ML0759c fbiA Probable F420 biosynthesis protein FbiA ML0759c, len: 379 aa. Probable fbiA, F420 biosynthesis protein, equivalent to FBIA F420 biosynthesis protein fbiA from Mycobacterium bovis BCG (see citations below). Highly similar to Rv3261|MTCY71.01|P96866|Z92771 Probable fbiA, F420 biosynthesis protein from Mycobacterium tuberculosis (331 aa), fasta scores: E(): 4.4e-116, (79.0% identity in 333 aa); and to Q9KZK9|AL353862 hypothetical protein from Streptomyces coelicolor (319 aa), fasta scores: E(): 5.8e-65, (52.7% identity in 334 aa). Contains Pfam match to entry PF01933 UPF0052, Uncharacterised protein family. Q9CCK1 No intermediary metabolism and respiration PF01933 Q9CCK1 GO:0000287,GO:0016773,GO:0016780,GO:0009108 2.7.8.- Rv3261 Rv3261 AL450380.2 Mycobrowser_v4 CDS 821180 822091 . - 0 ML0685c ML0685c Possible hydrolase ML0685c, len: 303 aa. Possible hydrolase, highly similar to CAD95491|Mb3370 Conserved hypothetical protein from M. bovis (297 aa), fasta scores: opt: 1343, E(): 1.1e-83, (67.133% identity in 286 aa overlap) and highly similar at the N terminus to O53387|AL123456|Rv3337 conserved hypothetical protein from M. tuberculosis (82 aa), Fasta scores: E(): 2.8e-17, (74.3% identity in 70 aa overlap) and at the C terminus to O53388|AL123456|Rv3338 conserved hypothetical protein from M. tuberculosis (214 aa), Fasta scores: E(): 0, (65.9% identity in 214 aa overlap). Weakly similar to several hydrolases e.g. BAC74778|Q826V8 Putative hydrolase from Streptomyces avermitilis (307 aa), fasta scores: opt: 286, E(): 1e-11, (29.392% identity in 296 aa overlap). Previously sequenced as Q49926|U00022 (303 aa), Fasta scores: E(): 0, (99.7% identity in 303 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Q7AQG1 No intermediary metabolism and respiration, conserved hypotheticals PF00561 Q7AQG1 GO:0016787 Rv3338,Rv3337 Rv3338,Rv3337 AL450380.2 Mycobrowser_v4 CDS 822127 823158 . + 0 ML0686 trpS Probable tryptophanyl-tRNA synthetase TrpS (TRYPTOPHAN--TRNA LIGASE) (TRPRS) (TRYPTOPHAN TRANSLASE) ML0686, len: 343 aa. Probable trpS, tryptophanyl-tRNA synthetase (EC 6.1.1.2), highly similar to SYW_MYCTU|O53386|Rv3336c trpS, tryptophanyl-tRNA synthetase from M. tuberculosis (336 aa), Fasta scores: E(): 0, (83.8% identity in 339 aa overlap); and CAD95489|Mb3369c from M. bovis (336 aa). Similar to many e.g. SYW_ECOLI|P00954 trpS, tryptophanyl tRNA synthetase from Escherichia coli (334 aa), Fasta scores: E(): 0, (49.6% identity in 335 aa overlap). Previously sequenced as SYW_MYCLE|Q49901 (343 aa), Fasta scores: E(): 0, (100.0% identity in 343 aa overlap). Contains Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. Q49901 No information pathways PF00579 Q49901 GO:0005737,GO:0004830,GO:0006436,GO:0005524 6.1.1.2 Rv3336c Rv3336c AL450380.2 Mycobrowser_v4 CDS 900394 901767 . - 0 ML0758c fbiB Probable F420 biosynthesis protein FbiB ML0758c, len: 457 aa. Probable fbiB, F420 biosynthesis protein, equivalent to FBIB F420 biosynthesis protein fbiB from Mycobacterium bovis BCG (see citations below). Highly similar to Rv3262|MTCY71.02|P96867|Z92771 Probable fbiB, F420 biosynthesis protein from Mycobacterium tuberculosis (448 aa), fasta scores: E(): 6.9e-138, (82.2% identity in 445 aa), and to SCE34.18|Q9KZK8|AL353862 putative oxidoreductase from Streptomyces coelicolor (443 aa), fasta scores: E(): 5.4e-65, (50.8% identity in 455 aa); and several hypothetical bacterial proteins. Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family. Contains Pfam match to entry PF01996 DUF129, Protein of unknown function. Q9CCK2 No intermediary metabolism and respiration PF00881,PF01996 Q9CCK2 GO:0043773,GO:0009108,GO:0030145,GO:0016491,GO:0030955,GO:0005525 6.3.2.- Rv3262 Rv3262 AL450380.2 Mycobrowser_v4 CDS 2312622 2313215 . + 0 ML1929 def PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) ML1929, len: 197 aa. Probable def, polypeptide deformylase (EC 3.5.1.31). Similar to M. tuberculosis polypeptide deformylase Rv0429c SW:DEF_MYCTU (P96275) (197 aa), Fasta scores: E(): 0, 83.7% identity in 196 aa overlap, and to many others e.g Streptomyces coelicolor polypeptide deformylase SW:DEF_STRCO (Q9XAQ2) (208 aa), Fasta scores: E(): 5.9e-20, 43.8% identity in 176 aa overlap. Contains Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase. Q9CBI2 No information pathways PF01327 Q9CBI2 GO:0042586,GO:0006412,GO:0005506 3.5.1.88 Rv0429c Rv0429c AL450380.2 Mycobrowser_v4 CDS 833873 834667 . - 0 ML0696c sdhB Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) ML0696c, len: 264 aa. Probable sdhB, iron-sulphur protein succinate dehydrogenase SdhB subunit (EC 1.3.99.1), highly similar to O53371|AL123456|Rv3319 sdhB, iron-sulphur protein succinate dehydrogenase from M. tuberculosis (263 aa), Fasta scores: E(): 0, (89.8% identity in 264 aa overlap); and CAD95442| from M. bovis (263 aa). Similar to many e.g. DHSB_ECOLI|P07014 sdhB, succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa), Fasta scores: E(): 0, (42.9% identity in 240 aa overlap). Previously sequenced as Q49916|U00022 (264 aa), Fasta scores: E(): 0, (100.0% identity in 264 aa overlap). Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. COFACTOR: BINDS THREE DIFFERENT IRON-SULFUR CLUSTERS: A 2FE-2S, A 3FE-4S AND A 4FE-4S. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'PLANT-TYPE' 2FE-2S AND 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. Q49916 No intermediary metabolism and respiration Q49916 GO:0051536,GO:0055114,GO:0000104,GO:0006099,GO:0009055 1.3.99.1 Rv3319 Rv3319 AL450380.2 Mycobrowser_v4 CDS 1441071 1441751 . + 0 ML1218 bioD Probable dethiobiotin synthetase BioD ML1218, len: 226 aa. Probable bioD, dethiobiotin synthetase (EC 6.3.3.3). Identical to the previously sequenced Mycobacterium leprae dethiobiotin synthetase (EC 6.3.3.3) SW:BIOD_MYCLE (P45486) (223 aa), Fasta scores: E(): 0, 99.6% identity in 223 aa overlap. Also highly similar to several others involved in biotin biosynthesis e.g. Mycobacterium bovis SW:BIOD_MYCBO (O52587) (226 aa), Fasta scores: E(): 0, 74.2% identity in 225 aa overlap and Mycobacterium tuberculosis Rv1570 SW:BIOD_MYCTU (O06620) (226 aa), Fasta scores: E(): 0, 74.2% identity in 225 aa overlap. P45486 No intermediary metabolism and respiration P45486 GO:0009102,GO:0004141,GO:0000287,GO:0005524 6.3.3.3 Rv1570 Rv1570 AL450380.2 Mycobrowser_v4 CDS 877854 879023 . + 0 ML0737 fadE25 Probable acyl-CoA dehydrogenase FadE25 ML0737, len: 389 aa. Probable fadE25, Acyl-CoA Dehydrogenase (EC 1.3.99.-), highly similar to Rv3274c|MTCY71.14c|P96879|Z92771 fadE25, Acyl-CoA Dehydrogenase from Mycobacterium tuberculosis (389 aa), fasta scores: E(): 3.5e-155, (92.0% identity in 389 aa). Highly similar to others e.g. Q9RIQ5|AJ250495 fatty acid acyl-CoA dehydrogenase fadE from Streptomyces lividans (385 aa), fasta scores:E(): 3.9e-106, (67.6% identity in 383 aa). Also similar to ML0660, ML0661 and shows weaker similarity to ML2563 from M. leprae. Previously sequenced as ACD_MYCLE|P46703. Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2. Contains PS00072 Acyl-CoA dehydrogenases signature 1. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. P46703 No lipid metabolism PF00441,PF02770,PF02771 P46703 GO:0003995,GO:0009055,GO:0055114,GO:0050660 1.3.99.- Rv3274c Rv3274c AL450380.2 Mycobrowser_v4 CDS 851949 853706 . + 0 ML0713 glpD INVOLVED IN AEROBIC RESPIRATION AND OXYDATION OF GLYCEROL. REDUCES AN ACCEPTOR AND GENERATES GLYCERONE PHOSPHATE FROM Sn-GLYCEROL 3-PHOSPHATE. POSSIBLY PLAY A ROLE IN METABOLISM OF RIBOFLAVIN, FAD,FMN [CATALYTIC ACTIVITY: SN-GLYCEROL 3-PHOSPHATE + ACCEPTOR = GLYCERONE PHOSPHATE + REDUCED ACCEPTOR]. Probable glycerol-3-phosphate dehydrogenase GlpD ML0713, len: 585 aa. Probable glpd, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), highly similar to O07168|AL123456|Rv3302c glpD2, glycerol-3-phosphate dehydrogenase from M. tuberculosis (585 aa), Fasta scores: E(): 3e-212, (90.8% identity in 584 aa overlap). Similar to many e.g. GLPD_ECOLI|P13035 glpD, glycerol-3-phosphate dehydrogenase from Escherichia coli (501 aa), Fasta scores: E(): 0, (35.2% identity in 492 aa overlap). Also similar to Q9ZB31|U57100 eriB, erythritol phosphate dehydrogenase from Brucella abortus (502 aa), Fasta scores: E(): 0, (35.4% identity in 483 aa overlap. Previously sequenced as GLPD_MYCLE|P53435 (585 aa), Fasta scores: E(): 0, (99.8% identity in 585 aa overlap). Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase. Contains PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. Contains PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY. P53435 No intermediary metabolism and respiration PF01266 P53435 GO:0009331,GO:0006072,GO:0055114,GO:0004368 1.1.5.3 Rv3302c Rv3302c AL450380.2 Mycobrowser_v4 CDS 873721 874545 . + 0 ML0732 birA BIRA ACTS BOTH AS A BIOTIN-OPERON REPRESSOR AND AS THE ENZYME THAT SYNTHESIZES THE COREPRESSOR, ACETYL-COA:CARBON-DIOXIDE LIGASE. THIS PROTEIN ALSO ACTIVATES BIOTIN TO FORM BIOTINYL-5'-ADENYLATE AND TRANSFERS THE BIOTIN MOIETY TO BIOTIN-ACCEPTING PROTEINS [CATALYTIC ACTIVITY: ATP + BIOTIN + APO-[ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP FORMING)] = AMP + PYROPHOSPHATE + [ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP FORMING)]] POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGASE) ML0732, len: 274 aa. Possible birA, bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15), highly similar to P96884|Z92771|Rv3279c|MTCY71.19c birA, bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase from Mycobacterium tuberculosis (266 aa), fasta scores: E(): 1.5e-69, (71.2% identity in 271 aa), and CAD95399| from M. bovis (266 aa). Similar to others e.g. P42975|BIRA_BACSU BirA bifunctional protein [Includ (325 aa), fasta scores: E(): 2.2e-12, (31.321% identity in 265 aa overlap). Lacks the N-terminal helix-turn-helix domain, so may not act as a repressor. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase. Q9CCL3 No intermediary metabolism and respiration PF02237,PF03099 Q9CCL3 GO:0006464,GO:0004077 Rv3279c Rv3279c AL450380.2 Mycobrowser_v4 CDS 918369 920138 . + 0 ML0775 lpqB probable conserved lipoprotein LpqB ML0775, len: 589 aa. Probable lpqB, conserved lipoprotein, highly similar to Rv3244c|MTCY20B11.19c|O05889|Z95121 lpqB, conserved lipoprotein from Mycobacterium tuberculosis (583 aa), fasta scores: E(): 3.2e-198, (87.9% identity in 579 aa); and CAD95364| from M. bovis (583 aa). Similar to other putative lipoproteins e.g. Q9KYX0|AL355774|SCE33.13C putative lipoprotein from Streptomyces coelicolor (615 aa), fasta scores: E(): 0.00039, (24.4% identity in 624 aa). Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CCJ0 No cell wall and cell processes PF10646,PF10647 Q9CCJ0 GO:0005886 Rv3244c Rv3244c AL450380.2 Mycobrowser_v4 CDS 1155160 1155675 . + 0 ML0988 recX PROBABLE REGULATORY PROTEIN RECX ML0988, len: 171 aa. Probable recX, regulatory protein. Identical to the previously sequenced Mycobacterium leprae putative regulatory protein RecX, though to interact with RecA SW:RECX_MYCLE (P37859) (171 aa), Fasta scores: E(): 0, 100.0% identity in 171 aa overlap. Also highly similar to RecX from Mycobacterium tuberculosis Rv2736c SW:RECX_MYCTU (O33280) (174 aa), Fasta scores: E(): 0, 77.0% identity in 174 aa overlap and several others. Note the overlap with upstream recA. P37859 No regulatory proteins, information pathways PF02631 P37859 GO:0006282,GO:0005737 Rv2736c Rv2736c AL450380.2 Mycobrowser_v4 CDS 2232818 2233159 . - 0 ML1849c rplN PROBABLE 50S RIBOSOMAL PROTEIN L14 RPLN ML1849c, len: 113 aa. Probable rplN,50S ribosomal protein L14. Similar to M. tuberculosis 50S ribosomal protein L14 Rv0714 SW:RL14_MYCTU (P95062) (122 aa), Fasta scores: E(): 0, 96.5% identity in 113 aa overlap. Contains Pfam match to entry PF00238 Ribosomal_L14, Ribosomal protein L14p/L23e. Contains PS00049 Ribosomal protein L14 signature. O32993 No information pathways PF00238 O32993 GO:0019843,GO:0003735,GO:0006412,GO:0015934 Rv0714 Rv0714 AL450380.2 Mycobrowser_v4 CDS 877244 877759 . + 0 ML0736 purE INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP). THIS SUBUNIT CAN ALONE TRANSFORM AIR TO CAIR, BUT IN ASSOCIATION WITH PURK, WHICH POSSESSES AN ATPASE ACTIVITY, AN ENZYME COMPLEX IS PRODUCED WHICH IS CAPABLE OF CONVERTING AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL CONDITION [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE = 1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)]. Probable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (AIR CARBOXYLASE) (AIRC) ML0736, len: 171 aa. Probable purE, phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21), highly similar to Rv3275c|MTCY71.15c|PUR6_MYCTU|P96880 purE, phosphoribosylaminoimidazole carboxylase catalytic subunit from Mycobacterium tuberculosis (174 aa), fasta scores: E(): 2.9e-49, (81.5% identity in 168 aa) and CAD95395| from M. bovis (174 aa). Similar to several e.g. PUR6_CORAM|Q44679 phosphoribosylaminoimidazole carboxylase catalytic subunit from Corynebacterium ammoniagenes (177 aa), fasta scores: E(): 1.1e-33, (66.2% identity in 148 aa). Previously sequenced as PUR6_MYCLE|P46702. Contains Pfam match to entry PF00731 AIRC, AIR carboxylase. P46702 No intermediary metabolism and respiration PF00731 P46702 GO:0004638,GO:0006189 4.1.1.21 Rv3275c Rv3275c AL450380.2 Mycobrowser_v4 CDS 875925 877244 . + 0 ML0735 purK INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP). POSSESSES AN ATPASE ACTIVITY THAT IS DEPENDENT ON THE PRESENCE OF AIR (AMINOIMIDAZOLE RIBONUCLEOTIDE). THE ASSOCIATION OF PURK AND PURE PRODUCES AN ENZYME COMPLEX CAPABLE OF CONVERTING AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL CONDITION [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE = 1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)] Probable phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (AIR CARBOXYLASE) (AIRC) ML0735, len: 439 aa. Probable purK, phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21), highly similar to Rv3276c|MTCY71.16c|PURK_MYCTU purK, phosphoribosylaminoimidazole carboxylase ATPase subunit from Mycobacterium tuberculosis (429 aa), fasta scores: E(): 0, (76.1% identity in 444 aa). Similar to several e.g. PURK_CORAM|Q44678 phosphoribosylaminoimidazole carboxylase ATPase subunit purK from Corynebacterium ammoniagenes (413 aa), fasta scores: E(): 9.9e-64, (48.3% identity in 404 aa). Previously sequenced as PURK_MYCLE|P46701. Contains Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain. P46701 No intermediary metabolism and respiration PF02222 P46701 GO:0005524,GO:0004638,GO:0006189 4.1.1.21 Rv3276c Rv3276c AL450380.2 Mycobrowser_v4 CDS 904676 906082 . + 0 ML0763 pmmA probable phosphomannomutase PmmA (PMM) (PHOSPHOMANNOSE MUTASE) ML0763, len: 468 aa. Probable pmmA, phosphomannomutase (EC 5.4.2.8), highly similar to O86374|Z95121|Rv3257c pmmA, probable phosphomannomutase from M. tuberculosis (465 aa), fasta scores: E(): 9.2e-162, (83.1% identity in 468 aa overlap); and CAD95377| from M. bovis (465 aa). Similar to several e.g. MANB_ECOLI|P24175 manB phosphomannomutase from Escherichia coli (456 aa), fasta scores: E(): 6.9e-58, (39.0% identity in 451 aa). Also similar to ML0366 and ML0706 from M. leprae. Contains Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase. Q9CCJ7 No intermediary metabolism and respiration PF00408,PF02878,PF02879,PF02880 Q9CCJ7 GO:0016868,GO:0005975 Rv3257c Rv3257c AL450380.2 Mycobrowser_v4 CDS 913624 915102 . + 0 ML0771 sahH THIOESTER HYDROLASE WHICH ACTING ON ETHER BOUNDS. COULD BE INVOLVED IN METHIONINE AND SELENOAMINO ACID METABOLISMS. ALSO INVOLVED IN ACTIVATED METHYL. CYCLE ADENOSYLHOMOCYSTEINE IS A COMPETITIVE INHIBITOR OF S-ADENOSYL-L-METHIONINE-DEPENDENT METHYL TRANSFERASE REACTIONS; THEREFORE ADENOSYLHOMOCYSTEINASE MAY PLAY A KEY ROLE IN THE CONTROL OF METHYLATIONS VIA REGULATION OF THE INTRACELLULAR CONCENTRATION OF ADENOSYLHOMOCYSTEINE [CATALYTIC ACTIVITY: S-ADENOSYL-L-HOMOCYSTEINE + H(2)O = ADENOSINE + L-HOMOCYSTEINE]. putative S-adenosyl-L-homocysteine hydrolase SahH ML0771, len: 492 aa. Probable sahH, adenosylhomocysteinase (EC 3.3.1.1), highly similar to Rv3248c|MTCY20B11.23c|SAHH_MYCTU|O08364 Probable sahH, adenosylhomocysteinase from M. tuberculosis (495 aa), fasta scores: E(): 1.1e-187, (91.4% identity in 489 aa), and CAD95368|Mb3276c from M. bovis (495 aa). Also highly similar to other adenosylhomocysteinases e.g. SAHH_TRIVA|P51540 adenosylhomocysteinase from Trichomonas vaginalis (486 aa), fasta scores: E(): 3.2e-121, (62.3% identity in 478 aa). Contains Pfam match to entry PF00670 AdoHcyase, S-adenosyl-L-homocysteine hydrolase. Contains PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. Contains PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. BELONGS TO THE ADENOSYLHOMOCYSTEINASE FAMILY. Q9CCJ4 No intermediary metabolism and respiration PF00670,PF05221 Q9CCJ4 GO:0005488,GO:0005737,GO:0006730,GO:0004013 3.3.1.1 Rv3248c Rv3248c AL450380.2 Mycobrowser_v4 CDS 468133 469299 . + 0 ML0375 alr Probable alanine racemase Alr ML0375, len: 388 aa. Probable alr, alanine racemase (EC 5.1.1.1), highly similar to Rv3423c|ALR_MYCTU|Q50705 alr, probable alanine racemase from M. tuberculosis (408 aa), Fasta scores: E(): 0, (84.6% identity in 382 aa overlap). Highly similar to other alanine racemases e.g. ALR_MYCSM|P94967 alr, alanine racemase from Mycobacterium smegmatis (389 aa), Fasta scores: E(): 0, (67.2% identity in 378 aa overlap); and O86786|ALR_STRCO|SC6G4.23 from Streptomyces coelicolor (391 aa). Previously sequenced as ALR_MYCLE|P38056 (388 aa), Fasta scores: E(): 0, (99.7% identity in 388 aa overlap). Contains 2 Pfam matches to entry PF00842 Ala_racemase, Alanine racemase. Belongs to the alanine racemase family. P38056 No intermediary metabolism and respiration PF00842,PF01168 P38056 GO:0008784,GO:0007047,GO:0009252,GO:0030170,GO:0008360,GO:0006522 5.1.1.1 Rv3423c Rv3423c AL450380.2 Mycobrowser_v4 CDS 916684 918372 . + 0 ML0774 mtrB probable two-component sensory transduction histidine kinase MtrB ML0774, len: 562 aa. Probable mtrB, sensor-like histidine kinase (EC 2.7.3.-) (see citations below), highly similar to Q50496|U14909|Rv3245c mtrB, sensor-like histidine kinase Mycobacterium (567 aa), fasta scores: E(): 2.2e-197, (88.3% identity in 566 aa); and CAD95365|Mb3273c from M. bovis (567 aa). Also similar to others e.g. Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (688 aa), fasta scores: E(): 5.1e-78, (46.507% identity in 544 aa overlap). And similar to ML0175, ML2124 and ML2440 from M. leprae. Contains hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains Pfam match to entry PF00512 signal, Histidine kinase. SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES. Q9CCJ1 No regulatory proteins PF00512,PF00672,PF02518 Q9CCJ1 GO:0016021,GO:0018106,GO:0005886,GO:0000155,GO:0000160,GO:0005524 2.7.13.3 Rv3245c Rv3245c AL450380.2 Mycobrowser_v4 CDS 925682 926164 . + 0 ML0781 ML0781 conserved hypothetical protein ML0781, len: 160 aa. Conserved hypothetical protein, highly similar to Rv3237c|MTCY20B11.12c|O05882|Z95121 Conserved hypothetical protein from Mycobacterium tuberculosis (160 aa), fasta scores: E(): 0, (80.6% identity in 160 aa): and CAD95357|Mb3265c from M. bovis (160 aa). Similar to other hypothetical bacterial proteins and more weakly to putative potassium channels e.g. Q9RV81|AE001964|DR1148 conserved hypothetical protein from Deinococcus radiodurans (175 aa), fasta scores: E(): 1.1e-19, (38.0% identity in 158 aa); Q58752|YD57_METJA Putative potassium channel protein from Methanococcus jannaschii (343 aa), fasta scores: E(): 0.0081, (32.000% identity in 75 aa overlap). Q9CCI6 No conserved hypotheticals PF02080 Q9CCI6 GO:0003824,GO:0008324,GO:0008152,GO:0006813,GO:0005488 Rv3237c Rv3237c AL450380.2 Mycobrowser_v4 CDS 921723 924545 . + 0 ML0779 secA1 PROBABLE PREPROTEIN TRANSLOCASE SECA1 SUBUNIT ML0779, len: 940 aa. Probable secA1, preprotein translocase subunit, component of secretion apparatus (see citations below), highly similar to Rv3240c|MTCY20B11.15c|SEA1_MYCTU|O05885 Probable secA1, preprotein translocase subunit from Mycobacterium tuberculosis (949 aa), fasta scores: E(): 0, (87.5% identity in 949 aa); and CAD95360|Mb3268c from M. bovis (949 aa). Highly similar to many e.g. P71533|SECA_MYCSM Preprotein translocase secA subunit from M. smegmatis (957 aa), fasta scores: E(): 0, (77.651% identity in 962 aa overlap). Also similar to ML2082 from M. leprae. Contains Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region. Contains PS01312 Protein secA signatures. BELONGS TO THE SECA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA, SECD|ML0487, SECE|ML1907, SECF|ML0488, SECG|ML0577 AND SECY|ML1833. P57996 No cell wall and cell processes PF01043,PF07516,PF07517 P57996 GO:0005737,GO:0065002,GO:0005886,GO:0005515,GO:0017038,GO:0006605,GO:0005524 Rv3240c Rv3240c AL450380.2 Mycobrowser_v4 CDS 492715 493824 . - 0 ML0396c ino2 Probable myo-inositol-1-phosphate synthase Ino2 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase) ML0396c, len: 369 aa. Probable ino2 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below). Identical to ML2692 a possible orthologue of M. tuberculosis ino1. Possibly a paralogue of Rv0046c|P71703|AL123456 ino1, myo-inositol-1-phosphate synthase from M. tuberculosis (367 aa), Fasta scores: E(): 0, (91.8% identity in 366 aa overlap). Highly similar to other bacterial myo-inositol-1-phosphate synthase and hypothetical proteins e.g. Q8NLE6 Myo-inositol-1-phosphate synthase from Corynebacterium glutamicum (363 aa), Fasta scores: E(): 0, (73.9% identity in 361 aa overlap); and Q9X8T5|SCH24_21c Hypothetical protein from Streptomyces coelicolor (360 aa). Previously sequenced as Q57240|U00015 (369 aa), Fasta scores: E(): 0, (100.0% identity in 369 aa overlap). Contains Pfam match to entry PF01658 Inos-1-P_synth, Myo-inositol-1-phosphate synthase. Q57240 No intermediary metabolism and respiration PF01658,PF07994 Q57240 Rv0046c Rv0046c AL450380.2 Mycobrowser_v4 CDS 2043781 2044290 . - 0 ML1695c ilvN PROBABLE ACETOLACTATE SYNTHASE (SMALL SUBUNIT) ILVN (ACETOHYDROXY-ACID SYNTHASE) (AHAS) (ALS) ML1695c, len: 169 aa. Probable ilvN, acetolactate synthase small subunit (EC 4.1.3.18). Highly similar to many acetolactate synthases, small subunit, involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVH_MYCAV (Q59499) (167 aa), Fasta scores: E(): 0, 78.9% identity in 166 aa overlap and Mycobacterium tuberculosis Rv3002c SW:ILVH_MYCTU (O53249) (168 aa), Fasta scores: E(): 0, 83.5% identity in 164 aa overlap. Contains Pfam match to entry PF01842 ACT, ACT domain. O33113 No intermediary metabolism and respiration PF01842,PF10369 O33113 GO:0016597,GO:0009082,GO:0003984 2.2.1.6 Rv3002c Rv3002c AL450380.2 Mycobrowser_v4 CDS 630654 631091 . + 0 ML0519 aroD INVOLVED AT THE THIRD STEP IN THE BIOSYNTHESIS OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO ACIDS (THE SHIKIMATE PATHWAY). CATALYZE A TRANS-DEHYDRATION VIA AN ENOLATE INTERMEDIATE [CATALYTIC ACTIVITY: 3-DEHYDROQUINATE = 3-DEHYDROSHIKIMATE + H(2)O]. 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) ML0519, len: 145 aa. aroD, 3-dehydroquinate dehydratase (EC 4.2.1.10), highly similar to AROQ_MYCTU|P36918|Rv2537c aroD, 3-dehydroquinate dehydratase from M. tuberculosis (146 aa), Fasta scores: E(): 0, (85.9% identity in 142 aa overlap); and CAD94751|Mb2566c from M. bovis (147 aa). Similar to many e.g. AROQ_CORPS|P96750 aroQ, 3-dehydroquinate dehydratase from Corynebacterium pseudotuberculosis (146 aa), Fasta scores: E(): 6.7e-33, (61.0% identity in 136 aa overlap). Contains Pfam match to entry PF01220 DHquinase_II, Dehydroquinase class II. Contains PS01029 Dehydroquinase class II signature. Belongs to the type-II 3-dehydroquinase family. Q9CCS3 No intermediary metabolism and respiration PF01220 Q9CCS3 GO:0009073,GO:0003855 4.2.1.10 Rv2537c Rv2537c AL450380.2 Mycobrowser_v4 CDS 554334 555053 . - 0 ML0454c pgsA Probable PI synthase PgsA1 (phosphatidylinositol synthase) (CDP-diacylglyceride--inositol3-phosphatidyltransferase) ML0454c, len: 239 aa. Probable pgsA1 (previously known as pgsA), PI synthase/CDP-diacylglyceride--inositol phosphatidyltransferase (EC 2.7.8.11), transmembrane protein, highly similar to Rv2612c|O06202|AL123456 pgsA1 probable PI synthase from M. tuberculosis (217 aa), Fasta scores: E(): 0, (79.3% identity in 213 aa overlap); and Q9F7Y9|PGSA phosphatidylinositol synthase from Mycobacterium smegmatis (222 aa). Shows weak similarity to PGSA_ECOLI|P06978 pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (738 aa), BlastP Expect 8.6. Previously sequenced as O07149|Z96801 (239 aa), Fasta scores: E(): 0, (100.0% identity in 239 aa overlap). Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Note that in Mycobacterium smegmatis, the psgA homologue is essential to the survival of the bacteria and seems cannot be compensated by any other enzyme of Mycobacterium smegmatis. O07149 No lipid metabolism PF01066 O07149 GO:0008654,GO:0016780,GO:0016020 Rv2612c Rv2612c AL450380.2 Mycobrowser_v4 CDS 672088 673107 . + 0 ML0555 ribG INVOLVED IN RIBOFLAVIN BIOSYNTHESIS (AT THE SECOND AND THIRD STEPS). CONVERTS 2,5-DIAMINO-6-(RIBOSYLAMINO)-4(3H)-PYRIMIDINONE 5'-PHOSPHATE INTO 5-AMINO-6-(RIBOSYLAMINO)-2,4(1H,3H)-PYRIMIDINEDIONE 5'-PHOSPHATE [CATALYTIC ACTIVITY 1: 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE + H(2)O = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NH(3)] [CATALYTIC ACTIVITY 2: 5-AMINO-6-(5-PHOSPHORIBITYLAMINO)URACIL + NADP(+) = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NADPH]. Probable bifunctional riboflavin-specific deaminase/reductase RibG: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) and 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase) ML0555, len: 339 aa. Probable ribG, bifunctional riboflavin biosynthesis protein, including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), highly similar to RIBD_MYCTU|P71677|Rv1409 ribG, bifunctional riboflavin biosynthesis protein from M. tuberculosis (339 aa), Fasta scores: E(): 0, (78.2% identity in 339 aa overlap); and CAD94305|Mb1444 from M. bovis (339 aa). Similar to many e.g. RIBD_BACSU|P17618 ribD, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)-uracil reductase from Bacillus subtilis (361 aa), Fasta scores: E(): 7.9e-33, (39.2% identity in 357 aa overlap). Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region. Contains Pfam match to entry PF01872 RibD_C, RibD C-terminal domain. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. IN THE N-TERMINAL SECTION; BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HTP REDUCTASE FAMILY. Q9CCP8 No intermediary metabolism and respiration PF00383,PF01872 Q9CCP8 GO:0008835,GO:0055114,GO:0009231,GO:0008270,GO:0008703 3.5.4.26,1.1.1.193 Rv1409 Rv1409 AL450380.2 Mycobrowser_v4 CDS 405519 407144 . + 0 ML0317 groEL2 65 kDa chaperonin 2 GroEL2 (Protein Cpn60-2) (groEL protein 2) (65 kDa antigen) (Heat shock protein 65) (Cell wall protein A) (Antigen A). ML0317, len: 541 aa. Probable groEL2 (alternate gene names: groL2, groEL-2, hsp65, hsp60), 65 kDa chaperonin 2 (see citations below), highly similar to Rv0440|CH62_MYCTU|P06806 groEL2, 60 kDa chaperonin 2 from M. tuberculosis (539 aa), Fasta scores: E(): 0, (94.8% identity in 541 aa overlap); and other bacterial chaperonin proteins. Previously sequenced as CH62_MYCLE|P09239 (540 aa), Fasta scores: E(): 0, (100.0% identity in 540 aa overlap). Also similar to ML0381 from M. leprae. Contains Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family. Contains PS00296 Chaperonins cpn60 signature. In M. tuberculosis purified 65 kDa antigen can elicit a strong delayed-type hypersensitivity reaction when infected in experimental animals. This protein is one of the major immunoreactive proteins of mycobacteria. This antigen contains epitopes that are common to various species of mycobacteria. Belongs to the chaperonin (hsp60) family. P09239 No virulence, detoxification, adaptation PF00118 P09239 GO:0005737,GO:0042026,GO:0051082,GO:0005524 Rv0440 Rv0440 AL450380.2 Mycobrowser_v4 CDS 837680 838768 . + 0 ML0700 add Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) ML0700, len: 362 aa. Probable add, adenosine deaminase (EC 3.5.4.4), highlt similar to O53365|AL123456|Rv3313c add, probable adenosine deaminase from M. tuberculosis (365 aa), Fasta scores: E(): 0, (88.2% identity in 356 aa overlap). Similar to many e.g. Q9AK25|ADD5_STRCO Probable adenosine deaminase 5 from Streptomyces coelicolor (396 aa), fasta scores: E(): 9.9e-99, 66.856% identity in 353 aa overlap); and ADD_ECOLI|P22333 add, adenosine deaminase from Escherichia coli (333 aa), Fasta scores: E(): 6.8e-19, (29.7% identity in 340 aa overlap). Previously sequenced as Q49907|U00022 (332 aa), Fasta scores: E(): 0, (99.7% identity in 332 aa overlap). Contains Pfam match to entry PF00962 A_deaminase, Adenosine/AMP deaminase. BELONGS TO THE ADENOSINE AND AMP DEAMINASES FAMILY. Q9CCL9 No intermediary metabolism and respiration PF00962 Q9CCL9 GO:0009168,GO:0004000 3.5.4.4 Rv3313c Rv3313c AL450380.2 Mycobrowser_v4 CDS 1035227 1035583 . + 0 ML0871 ML0871 conserved hypothetical protein ML0871, len: 118 aa. Similar to Mycobacterium tuberculosis hypothetical 12.5 kDa protein Rv2204c or MTCY190.15C SW:YM04_MYCTU (Q10393) (118 aa) fasta scores: E(): 0, 92.4% identity in 118 aa. Similar to many hypothetical proteins e.g. Streptomyces coelicolor hypothetical 12.4 kDa protein SC6G10.34C TR:Q9X819 (EMBL:AL049497) (118 aa) fasta scores: E(): 0, 73.7% id in 118 aa. Contains Pfam match to entry PF01521 HesB-like, HesB-like domain. Contains PS01152 Hypothetical hesB/yadR/yfhF family signature. BELONGS TO THE HESB/YADR/YFHF FAMILY. Q9CCF5 No conserved hypotheticals PF01521 Q9CCF5 GO:0051536,GO:0005198,GO:0016226 Rv2204c Rv2204c AL450380.2 Mycobrowser_v4 CDS 627742 628965 . + 0 ML0516 aroF Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). ML0516, len: 407 aa. aroF, chorismate synthase (EC 4.6.1.4), highly similar to AROC_MYCTU|P95013|Rv2540c aroF, chorismate synthase from M. tuberculosis (401 aa), Fasta scores: E(): 0, (88.0% identity in 401 aa overlap); and CAD94754|Mb2569c from M. bovis (401 aa). Similar to many e.g. Q9KXQ4|AROC_STRCO|SC9C5.20c from Streptomyces coelicolor (394 aa), E(): 6.3e-98, (65.365% identity in 384 aa overlap). Contains Pfam match to entry PF01264 Chorismate_synt, Chorismate synthase. Contains PS00788 Chorismate synthase signature 2. Contains PS00789 Chorismate synthase signature 3. Contains PS00787 Chorismate synthase signature 1. Belongs to the Chorismate synthase family. Cofactor: Reduced flavin. Q9CCS6 No intermediary metabolism and respiration PF01264 Q9CCS6 GO:0004107,GO:0009073 4.2.3.5 Rv2540c Rv2540c AL450380.2 Mycobrowser_v4 CDS 606840 608609 . + 0 ML0501 aspS Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (AspRS) (aspartic acid translase) ML0501, len: 589 aa. Probable aspS, aspartyl-tRNA synthetase (EC 6.1.1.12), highly similar to SYD_MYCTU|Q50649|Rv2572c aspS, aspartyl-tRNA synthetase from M. tuberculosis (596 aa), Fasta scores: E(): 0, (88.0% identity in 592 aa overlap); and CAD94787|Mb2602c from M. bovis (611 aa). And highly similar to many e.g. Q8FT19 Putative aspartyl-tRNA synthetase from Corynebacterium efficiens (617 aa), fasta scores: E(): 3.8e-190, (71.549% identity in 594 aa overlap); and SYD_ECOLI|P21889 aspS, aspartyl-tRNA synthetase from Escherichia coli (590 aa), Fasta scores: (46.8% identity in 583 aa overlap). Previously sequenced as SYD_MYCLE|P36429 (589 aa), Fasta scores: E(): 0, (99.8% identity in 589 aa overlap). Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to the class-II aminoacyl-tRNA synthetase family. P36429 No information pathways PF00152,PF01336,PF02938 P36429 GO:0004815,GO:0006422,GO:0005737,GO:0003676,GO:0005524 6.1.1.12 Rv2572c Rv2572c AL450380.2 Mycobrowser_v4 CDS 715032 715979 . - 0 ML0590c ML0590c Possible unidentified antibiotic-transport ATP-binding protein ABC transporter ML0590c, len: 315 aa. Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below), highly similar to O53149|AL123456|Rv1458c Possible unidentified antibiotic-transport ATP-binding protein ABC transporter from M. tuberculosis (313 aa), Fasta scores: E(): 3.1e-109, (88.0% identity in 308 aa overlap). Similar to many e.g. Q9XAC8 Putative ABC transporter, ATP-binding protein from Streptomyces coelicolor (307 aa), fasta scores: E(): 9e-68, (59.539% identity in 304 aa overlap). Previously sequenced as Q49707|U00013 (315 aa), Fasta scores: E(): 0, (100.0% identity in 315 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family. Q7AQH8 No cell wall and cell processes PF00005 Q7AQH8 GO:0016887,GO:0005524 Rv1458c Rv1458c AL450380.2 Mycobrowser_v4 CDS 888794 890971 . - 0 ML0747c ctpC Probable metal cation-transporting P-type ATPase C CtpC ML0747c, len: 725 aa. Probable ctpC, metal cation-transport ATPase P-type (EC 3.6.3.-), integral membrane protein, highly similar to Rv3270|MTCY71.10|CTPC_MYCTU|P96875 ctpC, metal cation-transport ATPase P-type from Mycobacterium tuberculosis (718 aa), fasta scores: E(): 0, (86.0% identity in 713 aa), and to P77894|CTPV_MYCTU Probable cation-transporting ATPase from M. tuberculosis (770 aa), fasta scores: E(): 2.9e-70, (36.970% identity in 779 aa overlap). Similar to other metal transporting ATPases e.g. Q8FUE3 Putative copper-transporting ATPase from Corynebacterium efficiens (578 aa), fasta scores: E(): 3.6e-72, (40.702% identity in 570 aa overlap). Contains hydrophobic, possible membrane-spanning region. Contains 2 Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00154 E1-E2 ATPases phosphorylation site. Contains PS01229 Hypothetical cof family signature 2. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Q9CCL1 No cell wall and cell processes PF00122,PF00702 Q9CCL1 GO:0006754,GO:0015662,GO:0016021,GO:0000287,GO:0030001,GO:0005886,GO:0005524 3.6.3.- Rv3270 Rv3270 AL450380.2 Mycobrowser_v4 CDS 412124 413545 . + 0 ML0323 cysS1 Probable cysteinyl-tRNA synthase 1 CysS1 (Cysteine--tRNA ligase 1) (CysRS 1) ML0323, len: 473 aa. Probable cysS1, cysteinyl-tRNA synthetase (EC 6.1.1.16), highly similar to Rv3580c|SYC1_MYCTU|P96862 cysS1, cysteinyl-tRNA synthetase from M. tuberculosis (469 aa), Fasta scores: E(): 0, (86.5% identity in 467 aa overlap). Similar to many others e.g. SYC_ECOLI|P21888 cysS, cysteinyl-tRNA synthetase from Escherichia coli (461 aa), Fasta scores: E(): 0, (42.0% identity in 460 aa overlap). Also similar to ML1302 from M. leprae. Contains Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C). Belongs to the class-I aminoacyl-tRNA synthetase family. Strongly similar to methionyl-tRNA synthetase. P57990 No information pathways PF01406,PF09190 P57990 GO:0004817,GO:0006423,GO:0005737,GO:0008270,GO:0005524 6.1.1.16 Rv3580c Rv3580c AL450380.2 Mycobrowser_v4 CDS 827878 829113 . - 0 ML0691c dacB1 Probable D-alanyl-D-alanine carboxypeptidase DacB1 (PENICILLIN-BINDING PROTEIN) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE) ML0691c, len: 411 aa. Probable dacB1, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), highly similar to O53380|AL123456|Rv3330 dacB1, D-alanyl-D-alanine carboxypeptidase from M. tuberculosis (405 aa), Fasta scores: E(): 0, (77.2% identity in 416 aa overlap); and CAD95475|Mb3363 from M. bovis (405 aa). Similar to several e.g. Q8FRR0 Putative penicillin-binding protein from Corynebacterium efficiens (447 aa), fasta scores: E(): 1.6e-50, (45.283% identity in 371 aa overlap). Previously sequenced as Q49917|U00022 (228 aa), Fasta scores: E(): 0, (100.0% identity in 228 aa overlap). Contains a probable N-terminal signal sequence. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY Q9CCM2 No cell wall and cell processes PF00768 Q9CCM2 GO:0009002,GO:0006508 Rv3330 Rv3330 AL450380.2 Mycobrowser_v4 CDS 658334 659593 . + 0 ML0543 dfp Probable DNA/pantothenate metabolism flavoprotein homolog Dfp ML0543, len: 419 aa. Probable dfp, DNA/pantothenate metabolism flavoprotein homolog, highly similar to DFP_MYCTU|P71661|Rv1391 probable dfp, DNA/pantothenate metabolism flavoprotein homolog from M. tuberculosis (418 aa), Fasta scores: E(): 1.8e-139, (87.0% identity in 409 aa overlap); and CAD94287|Mb1426 from M. bovis (418 aa). Similar to many e.g. DFP_ECOLI|P24285 dfp, DNA/pantothenate metabolism flavoprotein from Escherichia coli (430 aa), Fasta scores: E(): 0, (39.7% identity in 408 aa overlap). Contains match to Pfam entry PF02441 Flavoprotein. Q9CCQ5 No intermediary metabolism and respiration PF02441,PF04127 Q9CCQ5 GO:0015937,GO:0015941,GO:0004632,GO:0004633,GO:0010181 Rv1391 Rv1391 AL450380.2 Mycobrowser_v4 CDS 810693 811541 . + 0 ML0674 folD NECESSARY FOR THE BIOSYNTHESIS OF PURINES, THYMYDYLATE, METHIONINE, HISTIDINE, PANTOTHENATE, AND FORMYL TRNA-MET [CATALYTIC ACTIVITY: 5,10-METHYLENETETRAHYDROFOLATE + NADP(+) = 5,10-METHENYLTETRAHYDROFOLATE + NADPH] [CATALYTIC ACTIVITY: 5,10-METHENYLTETRAHYDROFOLATE + H(2)O = 10-FORMYLTETRAHYDROFOLATE]. Probable bifunctional protein fold: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase FolD ML0674, len: 282 aa. Probable folD, bifunctional enzyme include methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9), highly similar to O50385|AL123456|Rv3356c Probable folD, bifunctional enzyme from M. tuberculosis (281 aa), Fasta scores: E(): 0, (86.5% identity in 281 aa overlap); CAD95537|3391c from M. bovis (281 aa). Similar to many e.g. FOLD_ECOLI|P24186 folD, bifunctional methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase from Escherichia coli (287 aa), Fasta scores: E(): 0, (40.8% identity in 277 aa overlap). Previously sequenced as O32879|Z98271 (282 aa), Fasta scores: E(): 0, (99.6% identity in 282 aa overlap). Contains Pfam match to entry PF00763 THF_DHG_CYH, Tetrahydrofolate dehydrogenase/cyclohydrolase. SIMILAR TO OTHER DEHYDROGENASE/CYCLOHYDROLASE ENZYMES OR DOMAINS. O32879 No intermediary metabolism and respiration PF00763,PF02882 O32879 GO:0009396,GO:0000105,GO:0004477,GO:0009086,GO:0004488,GO:0006730,GO:0055114,GO:0006164,GO:0005488 3.5.4.9,1.5.1.5 Rv3356c Rv3356c AL450380.2 Mycobrowser_v4 CDS 634644 637496 . + 0 ML0524 ML0524 Probable amino acid decarboxylase ML0524, len: 950 aa. Probable amino acid decarboxylase (EC 4.1.1.-), highly similar to P95022|AL123456|Rv2531c Probable amino acid decarboxylase from M. tuberculosis (947 aa), Fasta scores: E(): 0, (86.4% identity in 951 aa overlap); and CAD94745|Mb2560c from M. bovis (947 aa). Similar to decarboxylases of ornithine/arginine/lysine e.g. Q9I2S7|PA1818 Probable Orn/Arg/Lys decarboxylase from Pseudomonas aeruginosa (751 aa), FASTA scores: E(): 4.9e-20, (28.807% identity in 729 aa overlap); and DCOR_ECOLI|P21169 speC, ornithine decarboxylase (constitutive) from Escherichia coli (731 aa), Fasta scores: E(): 3e-16, (26.8% identity in 650 aa overlap). Contains Pfam match to entry PF01276 OKR_DC_1, Orn/Lys/Arg decarboxylase. Seems to belong to the family of ornithine, lysine and arginine decarboxylases. Note that previously known as adi. Q9CCR8 No intermediary metabolism and respiration PF01276,PF03711 Q9CCR8 GO:0030170,GO:0003824 Rv2531c Rv2531c AL450380.2 Mycobrowser_v4 CDS 1276461 1277822 . - 0 ML1103c ML1103c PROBABLE OXIDOREDUCTASE ML1103c, len: 453 aa. Probable oxidoreductase. Similar to many putative oxidoreductase subunits including: Escherichia coli glycolate oxidase subunit GlcD SW:GLCD_ECOLI (P52075) (499 aa), Fasta scores: E(): 0, 38.8% identity in 456 aa overlap and Mycobacterium tuberculosis probable oxidoreductase Rv1257c TR:Q11061 (EMBL:Z77137) (455 aa), Fasta scores: E(): 0, 85.8% identity in 451 aa overlap. Contains Pfam match to entry PF01565 FAD_binding_4, FAD binding domain. Q9CC92 No intermediary metabolism and respiration PF01565,PF02913 Q9CC92 GO:0016491,GO:0050660 Rv1257c Rv1257c AL450380.2 Mycobrowser_v4 CDS 410871 411596 . + 0 ML0321 ispD Involved in the terpenoid biosynthesis pathway (at the third step). Catalyzes the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from 2C-methyl-D-erythritol 4-phosphate. [Catalytic activity: CTP and CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol]. Probable 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) (MEP cytidylyltransferase) (MCT) ML0321, len: 241 aa. Probable ispD, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase (EC 2.7.7.-), highly similar to Rv3582c|YZ82_MYCTU|P96864 probable ispD, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase from M. tuberculosis (231 aa), Fasta scores: E(): 0, (66.0% identity in 241 aa overlap). Similar to other bacterial 4-diphosphocytidyl-2C-methyl-D-erythritol synthases e.g. CAB77327|AL160331 from Streptomyces coelicolor (270 aa), Fasta scores: E(): 4.3e-25, (45.0% identity in 240 aa overlap) and AAF43207|AF230736 ispD from Escherichia coli (236 aa), Fasta scores: E(): 0.0016, (36.1% identity in 244 aa overlap). Contains the PS01295 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature and Pfam match to entry PF01128 UPF0007, Uncharacterized protein family UPF0007. Belongs to the IspD family. Q9CCW6 No intermediary metabolism and respiration PF01128 Q9CCW6 GO:0016114,GO:0050518 2.7.7.60 Rv3582c Rv3582c AL450380.2 Mycobrowser_v4 CDS 742717 744657 . + 0 ML0611 lepA Probable GTP-binding protein LepA ML0611, len: 646 aa. Probable lepA, GTP-binding protein (a protein of unknown function, but apparently with membrane-related functions and very similar to protein synthesis elongation factors; see citations below). Highly similar to LEPA_MYCTU|P71739|Rv2404c lepA, putative GTP-binding protein from M. tuberculosis (653 aa), Fasta scores: E(): 0, (88.0% identity in 649 aa overlap); and CAD97288|Mb2427c from M. bovis (653 aa). Similar to many e.g. LEPA_BACSU|P37949 lepA, GTP-binding protein from Bacillus subtilis (612 aa), Fasta scores: E(): 5.5e-144, (56.8% identity in 613 aa overlap). Previously sequenced as LEPA_MYCLE|P53530 (646 aa), Fasta scores: E(): 0, (99.8% identity in 646 aa overlap). Show weak similarity to ML1498, ML1877 and ML1878 from M. leprae. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains PS00301 GTP-binding elongation factors signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the GTP-binding elongation factor family, LepA subfamily. P53530 No intermediary metabolism and respiration PF00009,PF00679,PF03144,PF06421 P53530 GO:0003924,GO:0005525 Rv2404c Rv2404c AL450380.2 Mycobrowser_v4 CDS 493940 495748 . - 0 ML0397c ML0397c Possible transporter protein ML0397c, len: 602 aa. Possible transporter protein. Similar at the N-terminus to C-terminal (transporter) part of Q9RDI0 bifunctional carbohydrate binding and transport protein from Streptomyces coelicolor A3(2) (651 aa), Fasta scores: E(): 4.4e-35, (40.4% identity in 334 aa overlap). C-terminal half is similar to sugar permeases e.g. Escherichia coli AraH, L-arabinose transport system permease protein, SW:ARAH_ECOLI (P08532) (329 aa), Fasta scores: E(): 1.1e-26, 36.0% identity in 297 aa overlap. The N-terminal half shows weak similarity to other proteins containing PAS and DUF9 domains. There is a possibility that this is a signal transduction protein. Previously sequenced as Q49739|U00015 (577 aa), Fasta scores: E(): 0, (99.8% identity in 577 aa overlap). The C-terminal half is similar to ML1419 from M. leprae. The N-terminal half shows some similarity to ML1750 from M. leprae. Contains hydrophobic, possible membrane-spanning regions in the C-terminal half. Contains Pfam match to entry PF00989 PAS, PAS domain. Contains Pfam match to entry PF00990 DUF9, Domain of unknown function. Contains PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. Q9CCU8 No cell wall and cell processes PF00989,PF00990,PF02653 Q9CCU8 GO:0006355,GO:0004871,GO:0007165,GO:0006810,GO:0005215,GO:0016020 AL450380.2 Mycobrowser_v4 CDS 528622 529428 . - 0 ML0429c ML0429c Probable short-chain type dehydrogenase/reductase ML0429c, len: 268 aa. Probable ala-rich oxidoreductase, short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to Rv2509|O06172|AL123456 putative ala-rich oxidoreductase from M. tuberculosis (268 aa), Fasta scores: E(): 0, (88.8% identity in 267 aa overlap). Similar to many putative dehydrogenases e.g O86553|SC1F2.16c putative dehydrogenase from Streptomyces coelicolor (276 aa), FASTA scores: opt: 492, E(): 9.5e-23, (38.15% identity in 262 aa overlap). Previously sequenced as O07709|Z97179 (268 aa), Fasta scores: E(): 0, (100.0% identity in 268 aa overlap). Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenase/reductase (SDR) family. Q7AQJ3 No intermediary metabolism and respiration PF00106 Q7AQJ3 GO:0008152,GO:0016491,GO:0005488 Rv2509 Rv2509 AL450380.2 Mycobrowser_v4 CDS 558364 559269 . - 0 ML0458c ML0458c Possible oxidoreductase ML0458c, len: 301 aa. Possible oxidoreductase (EC 1.-.-.-), similar to several putative oxidoreductase from both bacteria and eukaryotes e.g. SPBC215.11C|O94315|AL033534 putative aldo-keto reductase from Schizosaccharomyces pombe (306 aa), Fasta scores: E(): 0, (53.5% identity in 288 aa overlap); and P25906|YDBC_ECOLI putative dehydrogenase from Escherichia coli K12 (286 aa). Previously sequenced as O07152|Z96801 (306 aa), Fasta scores: E(): 0, (100.0% identity in 301 aa overlap). Contains 2 Pfam matches to entry PF00248 aldo_ket_red, Aldo/keto reductase family. Q9CCT9 No intermediary metabolism and respiration PF00248 Q9CCT9 GO:0016491,GO:0055114 AL450380.2 Mycobrowser_v4 CDS 673151 674680 . - 0 ML0556c ML0556c INVOLVED IN TRANSPORT OF AMINOGLYCOSIDES AND TETRACYCLINE ACROSS THE MEMBRANE (EXPORT): DRUG RESISTANCE BY AN EXPORT MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. Aminoglycoside/tetracycline-transport integral membrane protein ML0556c, len: 509 aa. Aminoglycoside/tetracycline-transport integral membrane protein (see citation below), member of major facilitator superfamily (MFS), highly similar to P71678|AL123456|Rv1410c Aminoglycoside/tetracycline-transport integral membrane protein from M. tuberculosis (518 aa), Fasta scores: E(): 0, (82.0% identity in 506 aa overlap); and CAD94306|Mb1445c from M. bovis (518 aa). Similar to others e.g. P96712|D50098 bmr3, multidrug transporter from Bacillus subtilis (512 aa), Fasta scores: E(): 5.4e-24, (27.1% identity in 446 aa overlap). Also similar to ML1562. Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter. Contains PS00216 Sugar transport proteins signature 1. Note that the ML0556c-ML0557c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al., 2000) Q9CCP7 No cell wall and cell processes PF07690 Q9CCP7 GO:0006810,GO:0005215,GO:0016021 Rv1410c Rv1410c AL450380.2 Mycobrowser_v4 CDS 657981 658313 . + 0 ML0542 rpoZ Probable DNA-directed RNA polymerase omega chain RpoZ (Transcriptase omega chain) (RNA polymerase omega subunit) ML0542, len: 110 aa. Probable rpoZ, DNA-directed RNA polymerase omega chain (EC 2.7.7.6), highly similar to YD90_MYCTU|P71660|Rv1390 rpoZ, DNA-directed RNA polymerase omega chain from M. tuberculosis (110 aa), Fasta scores: E(): 0, (90.0% identity in 110 aa overlap); and CAD94286|Mb1425 from M. bovis (110 aa). Also similar to Q9KXS1|RPOZ_STRCO Probable DNA-directed RNA polymermerase omega chain from Streptomyces coelicolor (90 aa), fasta scores: E(): 8.4e-19, (71.250% identity in 80 aa overlap). Subunit: CONSISTS OF A SIGMA FACTOR AND THE RNAP CORE ENZYME WHICH IS COMPOSED OF 2 ALPHA CHAINS, 1 BETA CHAIN, 1 BETA' CHAIN AND 1 OMEGA CHAIN. Belongs to the RNA polymerase omega chain family. Q9CCQ6 No information pathways PF01192 Q9CCQ6 GO:0003899,GO:0006351,GO:0003677 2.7.7.6 Rv1390 Rv1390 AL450380.2 Mycobrowser_v4 CDS 718689 721298 . + 0 ML0593 ML0593 Conserved hypothetical protein ML0593, len: 869 aa. Conserved hypothetical protein, highly similar to YE61_MYCTU|O53152|Rv1461 Conserved hypothetical protein from M. tuberculosis (846 aa), Fasta scores: E(): 0, 54.3% identity in 920 aa overlap. N- and C-termini are similar to various bacterial hypothetical proteins e.g. Streptomyces coelicolor SCC22.07C, conserved hypothetical protein, TR:Q9XAD1 (EMBL:AL096839) (473 aa), Fasta scores: E(): 0, 45.5% identity in 853 aa overlap. Contains an intein from amino acids 202-587 inclusive. The intein is different to the one in the M. tuberculosis orthologue and at a different relative position. C-terminal half is similar to ML0594. Previously sequenced as SW:YE61_MYCLE (Q49689) (869 aa), Fasta scores: E(): 0, 99.9% identity in 869 aa overlap. Contains Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051). Contains PS00881 Protein splicing signature. Q49689 No conserved hypotheticals PF01458 Q49689 GO:0016539,GO:0016226,GO:0005515,GO:0004519 Rv1461 Rv1461 AL450380.2 Mycobrowser_v4 CDS 834667 836421 . - 0 ML0697c sdhA Probable succinate dehydrogenase (flavoprotein subunit) SdhA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) ML0697c, len: 584 aa. Probable sdhA, flavoprotein of succinate dehydrogenase SdhA subunit (EC 1.3.99.1), highly similar to O53370|AL123456|Rv3318 sdhA, succinate dehydrogenase from M. tuberculosis (590 aa), Fasta scores: E(): 0, (92.5% identity in 590 aa overlap); and CAD95440| from M. bovis (590 aa). Similar to many e.g. SW:DHSA_ECOLI (P10444) sdhA, succinate dehydrogenase flavoprotein subunit from Escherichia coli (588 aa), Fasta scores: E(): 0, (48.6% identity in 589 aa overlap). Previously sequenced as Q49924|U00022 (401 aa), Fasta scores: E(): 0, (97.2% identity in 395 aa overlap). Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. COFACTOR: FAD. SIMILAR TO THE FLAVOPROTEIN SUBUNITS OF OTHER SPECIES SUCCINATE DEHYDROGENASE AND OF FUMARATE REDUCTASE. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. Q9CCM1 No intermediary metabolism and respiration PF00890,PF02910 Q9CCM1 GO:0009055,GO:0022900,GO:0000104,GO:0006099,GO:0050660 1.3.99.1 Rv3318 Rv3318 AL450380.2 Mycobrowser_v4 CDS 2273276 2276812 . - 0 ML1891c rpoB DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) ML1891c, len: 1178 aa. Probable rpoB, DNA-directed RNA polymerase, beta chain (EC 2.7.7.6). Similar to M. tuberculosis DNA-directed RNA polymerase beta chain Rv0667 SW:RPOB_MYCTU (P47766) (1178 aa), Fasta scores: E(): 0, 94.9% identity in 1178 aa overlap, and to many others e.g. Synechocystis sp. SW:RPOB_SYNY3 (P77965) (1102 aa), Fasta scores: E(): 0, 55.0% identity in 1129 aa overlap. Contains Pfam match to entry PF00562 RNA_pol_B, RNA polymerase beta subunit. Contains PS01166 RNA polymerases beta chain signature. P30760 No information pathways PF00562,PF04560,PF04561,PF04563,PF04565,PF10385 P30760 GO:0003899,GO:0032549,GO:0006351,GO:0003677 2.7.7.6 Rv0667 Rv0667 AL450380.2 Mycobrowser_v4 CDS 926169 927326 . + 0 ML0782 ML0782 probable conserved integral membrane transport protein ML0782, len: 385 aa. Probable conserved integral membrane transport protein, possibly cation (Na/H) transporter, highly similar to Rv3236c|MTCY20B11.11c|O05881|Z95121 Probable conserved integral membrane transport protein from M. tuberculosis (385 aa), fasta scores: E(): 3.8e-117, (81.8% identity in 385 aa); and CAD95356|Mb3264c from M. bovis (385 aa). Similar to others e.g. O69958 Putative transmembrane transport protein from Streptomyces coelicolor (411 aa), fasta scores: E(): 1.5e-69, (51.882% identity in 372 aa overlap); and weakly similar to KEFB_ECOLI|P45522 glutathione-regulated potassium-efflux system protein kefB from Escherichia coli, fasta scores: E(): 4.7e-13, (26.0% identity in 362 aa). Contains hydrophobic, possible membrane-spanning regions. SEEMS TO BELONG TO THE CPA2 FAMILY. Q9CCI5 No cell wall and cell processes PF00999 Q9CCI5 GO:0016021,GO:0015299,GO:0006812 Rv3236c Rv3236c AL450380.2 Mycobrowser_v4 CDS 457993 459384 . + 0 ML0366 mrsA Probable phospho-sugar mutase / MrsA protein homolog ML0366, len: 463 aa. Probable mrsA, phosphoglucomutase or phosphomannomutase (EC 5.4.2.-), highly similar to Rv3441c|O06258|AL123456 mrsA, phosphoglucomutase or phosphomannomutase from M. tuberculosis (448 aa), Fasta scores: E(): 0, (87.6% identity in 445 aa overlap). Similar to many other phospho-sugar mutases e.g. Q53876|SC6G4.14 putative phospho-sugar mutase (similar to phosphomannomutase) from Streptomyces coelicolor (452 aa), Fasta scores: E(): 0, 59.3% identity in 452 aa overlap) and MANB_SALTY|P26341 manB, phosphomannomutase from Salmonella typhimurium (264 aa), and Q9KG46|BH0267 phosphoglucosamine mutase from Bacillus halodurans (447 aa), Fasta scores: E(): 0, (47.2% identity in 445 aa overlap). Previously sequenced as Q49869|U00020 (463 aa), Fasta scores: E(): 0, (100.0% identity in 463 aa overlap). Also similar to ML0706 and ML0763 from M. leprae. Contains Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. Belongs to the phosphohexose mutases family. Q49869 No intermediary metabolism and respiration PF00408,PF02878,PF02879,PF02880 Q49869 GO:0000287,GO:0008966,GO:0005975 5.4.2.10 Rv3441c Rv3441c AL450380.2 Mycobrowser_v4 CDS 1151513 1152691 . + 0 ML0985 ML0985 possible glycosyltransferase ML0985, len: 392 aa. Possible glycosyltransferase (EC 2.-.-.-). Identical to the previously sequenced Mycobacterium leprae possible glycosyl transferase TR:Q49841 (EMBL:Z94723) (392 aa), Fasta scores: E(): 0, 100.0% identity in 392 aa overlap. Also highly similar to Mycobacterium tuberculosis probable transferase Rv2739c TR:O33282 (EMBL:AL008967) (388 aa), Fasta scores: E(): 0, 80.9% identity in 388 aa overlap and Erwinia herbicola SW:CRTX_ERWHE (Q01330) (413 aa), Fasta scores: E(): 7.5e-07, 26.1% identity in 410 aa overlap. Q7AQB9 No intermediary metabolism and respiration Q7AQB9 GO:0016758,GO:0008152 Rv2739c Rv2739c AL450380.2 Mycobrowser_v4 CDS 843848 845464 . - 0 ML0706c pmmB Probable phosphomannomutase PmmB (PHOSPHOMANNOSE MUTASE) ML0706c, len: 538 aa. Probable pmmB, phosphomannomutase (EC 5.4.2.8), highly similar to O53360|AL123456|Rv3308 pmmB, probable phosphomannomutase from M. tuberculosis (534 aa), Fasta scores: E(): 0, (76.8% identity in 538 aa overlap); and CAD95428|Mb3336 from M. bovis (534 aa). Similar to several e.g. Q9AD82 Putative phosphomannomutase from Streptomyces coelicolor (549 aa), E(): 3e-78, (46.154% identity in 533 aa overlap). Shows weak similarity to ML0366 and ML0763. Previously sequenced as Q49913|U00022 (534 aa), Fasta scores: E(): 0, (99.8% identity in 534 aa overlap). Contains Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. Q9CCL7 No intermediary metabolism and respiration PF00408,PF02878,PF02879,PF02880 Q9CCL7 GO:0016868,GO:0000287,GO:0005975 Rv3308 Rv3308 AL450380.2 Mycobrowser_v4 CDS 700215 703019 . + 0 ML0578 ppc Involved in the Tricarboxylic acid cycle, through THE CARBOXYLATION OF PHOSPHOENOLPYRUVATE (PEP) IT FORMS OXALOACETATE, A FOUR-CARBON DICARBOXYLIC ACID SOURCE FOR THE TRICARBOXYLIC ACID CYCLE [CATALYTIC ACTIVITY : PHOSPHATE + OXALOACETATE = H(2)O + PHOSPHOENOLPYRUVATE + CO(2] Probable phosphoenolpyruvate carboxylase Ppc ML0578, len: 934 aa. Probable ppc, phosphoenolpyruvate carboxylase (EC 4.1.1.31), similar to many e.g. CAPP_RHOPA|O32483 ppc, phosphoenolpyruvate carboxylase from Rhodopseudomonas palustris (936 aa), Fasta scores: E(): 5.6e-160, (45.7% identity in 936 aa overlap). Previously sequenced as CAPP_MYCLE|P46710 (907 aa), Fasta scores: E(): 0, (100.0% identity in 907 aa overlap). Contains 2 Pfam matches to entry PF00311 PEPCase, Phosphoenolpyruvate carboxylase. Contains PS00781 Phosphoenolpyruvate carboxylase active site 1. Contains PS00393 Phosphoenolpyruvate carboxylase active site 2. Belongs to the PEPCase family. P46710 No intermediary metabolism and respiration PF00311 P46710 GO:0008964,GO:0006099,GO:0015977 4.1.1.31 AL450380.2 Mycobrowser_v4 CDS 397946 398677 . - 0 ML0311c psd Probable phosphatidylserine decarboxylase Psd ML0311c, len: 243 aa. Probable psd, phosphatidylserine decarboxylase (EC 4.1.1.65), highly similar to Rv0437c|O86324|AL123456 psd, possible phosphatidylserine decarboxylase from M. tuberculosis (231 aa), Fasta scores: E(): 0, (72.6% identity in 241 aa overlap). Similar to some other phosphatidylserine decarboxylases e.g. AAF41369|AE002447 phosphatidylserine decarboxylase precursor-related protein from Neisseria meningitidis (265 aa), Fasta scores: E(): 2.5e-23, (39.2% identity in 217 aa overlap); and Q92IU5 Phosphatidylserine decarboxylase from Rickettsia conorii (231 aa). Previously sequenced as Q9ZBM3|AL035159 (202 aa), Fasta scores: E(): 0, (99.5% identity in 202 aa overlap). The start codon is uncertain. Codon usage suggests an alternative start at codon 63 (approx). Contains Pfam match to entry to PF02666 PS_Dcarbxylase, Phosphatidylserine decarboxylase. Belongs to the phosphatidylserine decarboxylases family. Q9CCW9 No lipid metabolism PF02666 Q9CCW9 GO:0006646,GO:0004609,GO:0048037 4.1.1.65 Rv0437c Rv0437c AL450380.2 Mycobrowser_v4 CDS 595608 597971 . + 0 ML0491 relA INVOLVED IN THE METABOLISM OF PPGPP (AT THE FIRST STEP). IN EUBACTERIA PPGPP (GUANOSINE 3'-DIPHOSPHATE 5-'DIPHOSPHATE) IS A MEDIATOR OF THE STRINGENT RESPONSE THAT COORDINATES A VARIETY OF CELLULAR ACTIVITIES IN RESPONSE TO CHANGES IN NUTRITIONAL ABUNDANCE. THIS ENZYME CATALYZES THE FORMATION OF PPPGPP WHICH IS THEN HYDROLYSED TO FORM PPGPP [CATALYTIC ACTIVITY: ATP + GTP = AMP + GUANOSINE 3'-DIPHOSPHATE 5-'TRIPHOSPHATE]. PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'- PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE) ML0491, len: 787 aa. Probable relA, GTP pyrophosphokinase (EC 2.7.6.5), highly similar to RELA_MYCTU|Q50638|Rv2583c Probable relA, GTP pyrophosphokinase from M. tuberculosis (790 aa), Fasta scores: E(): 0, (93.4% identity in 790 aa overlap). Also similar to others e.g. O87331|RELA_CORGL|RELA|REL from Corynebacterium glutamicum (Brevibacterium flavum) (760 aa), FASTA scores: E(): 6.1e-209, (66.0% identity in 756 aa overlap). Previously sequenced as RELA_MYCLE|Q49640 (787 aa), Fasta scores: E(): 0, (99.9% identity in 787 aa overlap). Contains a probable helix-turn-helix motif at aa 41-62 (Score 1005, SD +2.61) Contains Pfam match to entry PF01842 ACT, ACT domain. Belongs to the RelA/SpoT family. Q49640 No intermediary metabolism and respiration PF01842,PF01966,PF02824,PF04607 Q49640 GO:0005525,GO:0008728,GO:0016597,GO:0015969,GO:0016301,GO:0005524 2.7.6.5 Rv2583c Rv2583c AL450380.2 Mycobrowser_v4 CDS 1118733 1119146 . - 0 ML0949c ML0949c Possible regulatory protein (TetR family) ML0949c, len: 137 aa. Possible regulatory protein, some similarity to other transcription regulator proteins e.g. Q92T19 Putative transcription regulator protein from Rhizobium meliloti (197 aa), fasta scores: E(): 0.04, (35.294% identity in 68 aa overlap). Contains a match to Pfam entry PF00440 Bacterial regulatory proteins, tetR family. Q9CCD1 No regulatory proteins PF00440 Q9CCD1 GO:0003700,GO:0006355 AL450380.2 Mycobrowser_v4 CDS 581225 581791 . + 0 ML0481 ruvC NUCLEASE THAT RESOLVES HOLLIDAY JUNCTION INTERMEDIATES IN GENETIC RECOMBINATION. CLEAVES THE CRUCIFORM STRUCTURE IN SUPERCOILED DNA BY NICKING TO STRANDS WITH THE SAME POLARITY AT SITES SYMMETRICALLY OPPOSED AT THE JUNCTION IN THE HOMOLOGOUS ARMS AND LEAVES A 5'TERMINAL PHOSPHATE AND A 3'TERMINAL HYDROXYL GROUP [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE AT A JUNCTION SUCH AS A RECIPROCAL SINGLE-STRANDED CROSSOVER BETWEEN TWO HOMOLOGOUS DNA DUPLEXES (HOLLIDAY JUNCTION)]. Probable crossover junction endodeoxyribonuclease RuvC (HOLLIDAY JUNCTION NUCLEASE) (HOLLIDAY JUNCTION RESOLVASE). ML0481, len: 188 aa. Probable ruvC, Holliday junction resolvase (EC 3.1.22.4) (see citations below), highly similar to RUVC_MYCTU|Q50627|Rv2594c ruvC, crossover junction endodeoxyribonuclease from M. tuberculosis (188 aa), Fasta scores: E(): 0, (81.5% identity in 184 aa overlap). Also highly similar to others e.g. Q9AE11|RUVC from Corynebacterium glutamicum (Brevibacterium flavum) (221 aa), fasta scores: E(): 9.7e-41, (57.672% identity in 189 aa overlap); and Q9L289|RUVC_STRCO|SCL2.10c from Streptomyces coelicolor (188 aa), fasta scores: E(): 4.2e-39, (64.286% identity in 168 aa overlap). Previously sequenced as RUVC_MYCLE|P40834 (188 aa), Fasta scores: E(): 0, (100.0% identity in 188 aa overlap). Contains Pfam match to entry PF02075 RuvC, Crossover junction endodeoxyribonuclease RuvC. Contains PS01321 Crossover junction endodeoxyribonuclease RuvC signature. Contains PS00572 Glycosyl hydrolases family 1 active site. P40834 No information pathways PF02075 P40834 GO:0006281,GO:0008821,GO:0000287,GO:0003676,GO:0006310 3.1.22.4 Rv2594c Rv2594c AL450380.2 Mycobrowser_v4 CDS 836930 837391 . - 0 ML0699c sdhC Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) ML0699c, len: 153 aa. Probable sdhC, cytochrome B-556 of succinate dehydrogenase SdhC subunit (EC 1.3.99.1), transmembrane protein, highly similar but longer than O53368|AL123456|Rv3316 sdhC, cytochrome B-556 of succinate dehydrogenase from M. tuberculosis (112 aa), Fasta scores: E(): 0, (88.4% identity in 112 aa overlap); and CAD95437|Mb3345 from M. bovis (112 aa). Similar to many e.g. Q9KZ88 Putative succinate dehydrogenase membrane subunit from Streptomyces coelicolor (126 aa), fasta scores: E(): 5.4e-24, (57.273% identity in 110 aa overlap). Previously sequenced as Q49919|U00022 (244 aa), Fasta scores: E(): 0, (100.0% identity in 153 aa overlap). Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. BELONGS TO THE CYTOCHROME B560 FAMILY. Q9CCM0 No intermediary metabolism and respiration PF01127 Q9CCM0 GO:0016020,GO:0000104,GO:0006099,GO:0009055 Rv3316 Rv3316 AL450380.2 Mycobrowser_v4 CDS 2327636 2327899 . + 0 ML1941 xseB BIDIRECTIONALLY DEGRADES SINGLE-STRANDED DNA INTO LARGE ACID-INSOLUBLE OLIGONUCLEOTIDES, WHICH ARE THEN DEGRADED FURTHER INTO SMALL ACID-SOLUBLE OLIGONUCLEOTIDES [CATALYTIC ACTIVITY: EXONUCLEOLYTIC CLEAVAGE IN EITHER 5'- TO 3'- OR 3'- TO 5'-DIRECTION TO YIELD 5'-PHOSPHOMONONUCLEOTIDES.] PROBABLE EXODEOXYRIBONUCLEASE VII (SMALL SUBUNIT) XSEA (EXONUCLEASE VII SMALL SUBUNIT) ML1941, len: 87 aa. Probable xseB, exonuclease VII small subunit (EC 3.1.11.6). Similar to M. tuberculosis exonuclease VII small subunit xseB Rv1107c, and to many others e.g. Escherichia coli exodeoxyribonuclease large subunit SW:EX7S_ECOLI (P22938) (79 aa), Fasta scores: E(): 0.021, 41.8% identity in 55 aa overlap. Q9X784 No information pathways PF02609 Q9X784 GO:0005737,GO:0008855,GO:0009318,GO:0006308 3.1.11.6 Rv1107c Rv1107c AL450380.2 Mycobrowser_v4 CDS 590037 591830 . + 0 ML0487 secD Probable protein-export membrane protein SecD ML0487, len: 597 aa. Probable secD, protein-export membrane protein (integral membrane protein) (see citation below), highly similar to SECD_MYCTU|Q50634|Rv2587c secD, putative protein-export membrane protein from M. tuberculosis (573 aa), Fasta scores: E(): 3.5e-141, (80.6% identity in 583 aa overlap); and CAD94803|Mb2618c from M. bovis (573 aa). Also similar to others e.g. Q53955|SECD_STRCO from Streptomyces coelicolor (570 aa), FASTA scores: E(): 2.6e-35, (37.655% identity in 563 aa overlap. Previously sequenced as SECD_MYCLE|P38387 (571 aa), Fasta scores: E(): 0, (99.8% identity in 571 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Belongs to the secD/secF family, secD family. Part of the prokaryotic protein translocation apparatus which comprises SecA1|ML0799, SecA2|ML2082c, SecD|ML0487, secG|ML0577,, SecE|ML1907, SecF|ML0488 and SecY|ML1833. P38387 No cell wall and cell processes PF07549 P38387 GO:0015450,GO:0016021,GO:0065002,GO:0005886,GO:0015628,GO:0015627,GO:0009276 Rv2587c Rv2587c AL450380.2 Mycobrowser_v4 CDS 769119 771272 . + 0 ML0637 uvrD2 INVOLVED IN NUCLEOTIDE EXCISION REPAIR. HAS BOTH ATPASE AND HELICASE ACTIVITIES. UNWINDS DNA DUPLEXES WITH 3' TO 5' POLARITY WITH RESPECT TO THE BOUND STRAND AND INITIATES UNWINDING MOST EFFECTIVELY WHEN A SINGLE-STRANDED REGION IS PRESENT. INVOLVED IN THE POSTINCISION EVENTS OF NUCLEOTIDE EXCISION REPAIR AND METHYL-DIRECTED MISMATCH REPAIR. Probable ATP-dependent DNA helicase II UvrD2 ML0637, len: 717 aa. Probable uvrD2, ATP dependent DNA helicase II (EC 3.6.1.-), highly similar to UVRD_MYCTU|O53344|Rv3198c uvrD2, probable ATP-dependent DNA helicase II from M. tuberculosis (700 aa), Fasta scores: E(): 0, (82.9% identity in 706 aa overlap); and CAD95314|Mb3222c (700 aa) from M. bovis. Similar to many e.g. UVRD_ECOLI|P03018 uvrD, DNA helicase II from Escherichia coli (720 aa), Fasta scores: E(): 1.1e-20, (32.6% identity in 660 aa overlap). And similar to ML0153|uvrD1. Previously sequenced as UVRD_MYCLE|P53528 (457 aa), Fasta scores: E(): 0, (100.0% identity in 439 aa overlap). Contains Pfam match to entry PF00570 HRDC, HRDC domain. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. P53528 No information pathways PF00570,PF00580 P53528 GO:0004003,GO:0003677,GO:0006281,GO:0006260,GO:0005622,GO:0005524 3.6.1.- Rv3198c Rv3198c AL450380.2 Mycobrowser_v4 CDS 1648224 1650959 . - 0 ML1381c polA PROBABLE DNA POLYMERASE I POLA ML1381c, len: 911 aa. Probable polA, DNA polymerase I (EC 2.7.7.7). Highly similar to DNA polymerase I (EC 2.7.7.7) (PolI) from many bacteria including: Escherichia coli SW:DPO1_ECOLI (P00582) (928 aa), Fasta scores: E(): 0, 36.4% identity in 945 aa overlap and Mycobacterium tuberculosis Rv1629 SW:DPO1_MYCTU (Q07700) (904 aa), Fasta scores: E(): 0, 85.2% identity in 901 aa overlap. Previously sequenced SW:DPO1_MYCLE (P46835) (911 aa), Fasta scores: E(): 0, 99.9% identity in 911 aa overlap. Contains Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease. Contains Pfam match to entry PF00476 DNA_pol_A, DNA polymerase family A. Contains PS00447 DNA polymerase family A signature. P46835 No information pathways PF00476,PF01367,PF02739 P46835 GO:0008409,GO:0003677,GO:0006281,GO:0006260,GO:0003887,GO:0005622,GO:0008408 2.7.7.7 Rv1629 Rv1629 AL450380.2 Mycobrowser_v4 CDS 552241 553365 . - 0 ML0452c ML0452c Probable alpha-mannosyltransferase PimA ML0452c, len: 374 aa. Probable pimA, alpha-mannosyltransferase (EC 2.4.1.-), highly similar to Rv2610c|O06204|AL123456 pimA, alpha-mannosyltransferase from M. tuberculosis (378 aa), Fasta scores: E(): 0, (82.3% identity in 378 aa overlap). N-terminus is highly similar to Q9FY7 putative alpha-mannosyl transferase (fragment) from Mycobacterium smegmatis (27 aa) (see citation below). Also highly similar to Q9L284|SCL2.15c putative sugar transferase from Streptomyces coelicolor (387 aa), FASTA scores: opt: 1222, E(): 1.8e-67, (52.95% identity in 376 aa overlap); and similar in part to various proteins e.g. Q9R6U1|U45308 sqdX, required for biosynthesis of the sulfolipid sulfoquinovosyldiacylglycerol from Synechococcus sp. (377 aa), Fasta scores: E(): 6.9e-12, (25.9% identity in 390 aa overlap) and to CDS from the Bordetella parapertussis ipopolysaccharide biosynthesis locus e.g. O52848|AJ224768 wlbH, putative glcNac transferase (390 aa), Fasta scores: E(): 6.1e-12, (27.3% identity in 392 aa overlap). Previously sequenced as O07147|Z96801 (374 aa), Fasta scores: E(): 0, (100.0% identity in 374 aa overlap). Shows weak similarity to ML0886, ML1715 and ML2443 from M. leprae. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O07147 No lipid metabolism PF00534 O07147 GO:0043750,GO:0009058 2.4.1.57 Rv2610c Rv2610c AL450380.2 Mycobrowser_v4 CDS 956157 957890 . - 0 ML0808c entC COULD BE INVOLVED IN ENTEROBACTIN BIOSYNTHESIS. ENTEROBACTIN IS AN IRON-CHELATING COMPOUND INVOLVED IN TRANSPORTING IRON FROM THE BACTERIAL ENVIRONMENT INTO THE CELL CYTOPLASM. COULD BE ALSO INVOLVED IN 2,3-DIHYDROXYBENZOATE OR ENTEROCHELIN OR MENAQUINONE BIOSYNTHESIS [CATALYTIC ACTIVITY: CHORISMATE = ISOCHORISMATE]. probable isochorismate synthase EntC ML0808c, len: 577 aa. Probable entC, isochorismate synthase (EC 5.4.99.6), highly similar to Rv3215|MTCY07D11.11c|O05851|Z95120 entC, isochorismate synthase from Mycobacterium tuberculosis (372 aa), fasta scores: E(): 0, (73.5% identity in 366 aa) and to Bacillus subtilis isochorismate synthase dhbC (398 aa) DHBC_BACSU|P45744 fasta scores: E(): 0, 37.9% identity in 396 aa. Also similar to ML0236 and ML1269 from M. leprae. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. Q9CCH5 No intermediary metabolism and respiration PF00425 Q9CCH5 GO:0008909,GO:0009058 Rv3215 Rv3215 AL450380.2 Mycobrowser_v4 CDS 1064747 1066264 . - 0 ML0899c ML0899c Possible conserved integral membrane protein ML0899c, len: 505 aa. Possible conserved integral membrane protein. Identical to the previously sequenced Mycobacterium leprae putative integral membrane protein TR:O69566 (EMBL:AL022602) (505 aa), Fasta scores: E(): 0, 100.0% identity in 505 aa overlap. Also highly similar to Mycobacterium tuberculosis putative membrane protein Rv2174 TR:O53508 (EMBL:AL021957) (516 aa), Fasta scores: E(): 0, 78.9% identity in 502 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q7AQD1 No cell wall and cell processes Q7AQD1 Rv2174 Rv2174 AL450380.2 Mycobrowser_v4 CDS 1183484 1184176 . - 0 ML1013c ideR TRANSCRIPTIONAL REGULATORY PROTEIN (REPRESSOR AND ACTIVATOR), IRON-BINDING REPRESSOR OF SIDEROPHORE BIOSYNTHESIS AND IRON UPTAKE. SEEMS TO REGULATE A VARIETY OF GENES ENCODING A VARIETY OF PROTEINS e.g. TRANSPORTERS, PROTEINS INVOLVED IN SIDEROPHORE SYNTHESIS AND IRON STORAGE, MEMBERS OF THE PE/PPE FAMILY, ENZYMES INVOLVED IN LIPID METABOLISM, TRANSCRIPTIONAL REGULATORY PROTEINS, ETC. ALSO ACTIVATOR OF BFRA GENE. IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER ML1013c, len: 230 aa. Probable ideR, iron dependent repressor and activator. Highly similar to multiple iron-binding regulatory proteins such as Mycobacterium tuberculosis Rv2711 SW:IDER_MYCTU (Q50495) (230 aa), Fasta scores: E(): 0, 90.0% identity in 230 aa overlap and Corynebacterium diphtheriae SW:DTXR_CORDI (P33120) (226 aa), Fasta scores: E(): 0, 56.1% identity in 230 aa overlap. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor. Q9CCB5 No regulatory proteins PF01325,PF02742,PF04023 Q9CCB5 GO:0005506,GO:0006355,GO:0006350,GO:0003700,GO:0005737 Rv2711 Rv2711 AL450380.2 Mycobrowser_v4 CDS 965933 967120 . + 0 ML0817 moeB1 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) ML0817, len: 395 aa. Probable moeB1, molybdopterin cofactor biosynthesis protein. Similar to Rv3206c|O05860|AL123456 M. tuberculosis moeB homologue (392 aa), Fasta scores: E(): 0, 86.4% identity in 391 aa overlap and to Rv3116|O05792|AL123456 M. tuberculosis moeB2 putative molybdopterin biosynthesis protein (389 aa), Fasta scores: E(): 0, 57.8% identity in 384 aa overlap. Similar to many e.g. Q9ZNW0|AF124160 Arabidopsis thaliana cnx5, molybdopterin synthase sulphurylase, (464 aa), Fasta scores: E(): 0, 34.5% identity in 406 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain. Contains Pfam match to entry PF00899 ThiF_family, ThiF family. BELONGS TO THE HesA /MoeB/ThiF FAMILY Q9CCG8 No intermediary metabolism and respiration PF00581,PF00899,PF05237 Q9CCG8 GO:0003824,GO:0008152,GO:0005488 Rv3206c Rv3206c AL450380.2 Mycobrowser_v4 CDS 988461 990389 . + 0 ML0833 dnaG PROBABLE DNA PRIMASE DNAG ML0833, len: 642 aa. Probable dnaG, DNA primase (EC 2.7.7.-). Similar to Rv2343c|PRIM_MYCTU|P95239 Mycobacterium tuberculosis DNA primase (639 aa) fasta scores: E(): 0, 80.4% identity in 642 aa, and to O52200|AF027507 Mycobacterium smegmatis primase dnaG (636 aa) fasta scores: E(): 0, 76.2% id in 642 aa. Contains Pfam match to entry PF01751 Toprim, Toprim domain. Contains Pfam match to entry PF01807 zf-CHC2, CHC2 zinc finger. Q9CCG2 No information pathways PF01751,PF01807,PF08275,PF08278,PF10410 Q9CCG2 GO:0003896,GO:0006269,GO:0005658,GO:0006350,GO:0008270,GO:0003677 2.7.7.- Rv2343c Rv2343c AL450380.2 Mycobrowser_v4 CDS 1091351 1092151 . + 0 ML0922 wag31 CONSERVED HYPOTHETICAL PROTEIN WAG31 ML0922, len: 266 aa. Probable wag31, conserved hypothetical protein. Identical to the previously sequenced and characterised Mycobacterium leprae antigen 84 SW:AG84_MYCLE (P46815) (266 aa), Fasta scores: E(): 0, 100.0% identity in 266 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv2145c SW:AG84_MYCTU (P46816) (260 aa), Fasta scores: E(): 0, 83.1% identity in 266 aa overlap. Similar to ML2253c from M. leprae. Contains several possible coiled-coil regions. Note previously known as ag84. P46815 No cell wall and cell processes PF05103 P46815 GO:0005737 Rv2145c Rv2145c AL450380.2 Mycobrowser_v4 CDS 1002562 1004115 . + 0 ML0844 narK PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK (NITRITE FACILITATOR 1) ML0844, len: 517 aa. Probable narK, nitrite extrusion protein, possibly member of major facilitator superfamily (MFS). Similar to Mycobacterium tuberculosis putative nitrite extrusion protein narK1 or Rv2329c or MTCY3G12.05 TR:P71883 (EMBL:Z79702) (515 aa) fasta scores: E(): 0, 69.3% identity in 488 aa and to Escherichia coli nitrite extrusion protein 2 narU SW:NARU_ECOLI (P37758; P77696) (462 aa) fasta scores: E(): 0, 36.6% identity in 459 aa. There is a frameshift near the C-terminus relative to the M. tuberculosis homologue. Previously sequenced as TR:O32974 (EMBL:Z98741). Contains hydrophobic, probable membrane-spanning regions. BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS. O32974 No cell wall and cell processes PF07690 O32974 Rv2329c Rv2329c AL450380.2 Mycobrowser_v4 CDS 1019693 1020445 . - 0 ML0857c ML0857c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML0857c, len: 250 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 26.9 kDa protein Rv2219 or MTCY190.30 SW:YM19_MYCTU (Q10405) (250 aa) fasta scores: E(): 0, 80.8% identity in 250 aa. Similar to Streptomyces coelicolor putative integral membrane protein SC3H12.04 TR:CAB90843 (EMBL:AL355740) (234 aa) fasta scores: E(): 1.2e-26, 39.6% identity in 230 aa and to Streptomyces coelicolor putative integral membrane protein SC5F7.05 TR:Q9S2P0 (EMBL:AL096872) (234 aa) fasta scores: E(): 1.2e-26, 39.6% identity in 230 aa. Previously sequenced as TR:O32963 (EMBL:Z98741). Contains hydrophobic, possible membrane-spanning regions. Q7AQE8 No cell wall and cell processes Q7AQE8 Rv2219 Rv2219 AL450380.2 Mycobrowser_v4 CDS 1250667 1251530 . + 0 ML1088 sugB PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB ML1088, len: 287 aa. Probable sugB, sugar-transport integral membrane protein ABC transporter. Previously sequenced Mycobacterium leprae MalG TR:Q49977 (EMBL:U15180) (296 aa), Fasta scores: E(): 0, 100.0% identity in 287 aa overlap. Also highly similar to many putative membrane transport proteins including: Mycobacterium tuberculosis probable sugar transport protein Rv1237 TR:O50453 (EMBL:AL021006) (274 aa), Fasta scores: E(): 0, 89.4% identity in 274 aa overlap and Thermococcus litoralis inner membrane protein MalG TR:O51925 (EMBL:AF012836) (278 aa), Fasta scores: E(): 4.1e-31, 35.9% identity in 270 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Q9CCA1 No cell wall and cell processes PF00528 Q9CCA1 GO:0005886,GO:0006810,GO:0005215,GO:0016021 Rv1237 Rv1237 AL450380.2 Mycobrowser_v4 CDS 1012138 1013133 . + 0 ML0852 ribF PROBABLE BIFUNCTIONAL FAD SYNTHETASE/RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF: RIBOFLAVIN KINASE (FLAVOKINASE) + FMN ADENYLYLTRANSFERASE (FAD PYROPHOSPHORYLASE) (FAD SYNTHETASE)(FAD DIPHOSPHORYLASE) (FLAVIN ADENINE DINUCLEOTIDE SYNTHETASE) ML0852, len: 331 aa. Probable ribF, FAD synthetase/riboflavin biosynthesis protein, bifunctional enzyme (EC 2.7.1.26. Similar to Mycobacterium tuberculosis riboflavin kinase ribF or Rv2786c or MTV002.51C TR:O33328 (EMBL:AL008967) (331 aa) fasta scores: E(): 0, 87.5% identity in 327 aa and to many others e.g. Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF (includes riboflavin kinase) ribF SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 0, 47.7% identity in 321 aa. Previously sequenced as TR:O32968 (EMBL:Z98741). Contains Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase. O32968 No intermediary metabolism and respiration PF01687,PF06574 O32968 GO:0009231,GO:0008531,GO:0003919 2.7.7.2,2.7.1.26 Rv2786c Rv2786c AL450380.2 Mycobrowser_v4 CDS 2028724 2029326 . - 0 ML1683c hupB PROBABLE DNA-BINDING PROTEIN HU HOMOLOG HUPB (HISTONE-LIKE PROTEIN) (HLP) (21-KDA LAMININ-2-BINDING PROTEIN) ML1683c, len: 200 aa. Probable hupB, DNA-binding protein HU homolog. Highly similar to Mycobacterial histone-like proteins e.g. Mycobacterium smegmatis TR:Q9ZHC5 (EMBL:AF068138) (269 aa), BlastP Expect 0.0014 and Mycobacterium tuberculosis Rv2986c SW:DBH_MYCTU (P95109) (214 aa), Fasta scores: E(): 0, 80.1% identity in 216 aa overlap. Also similar to many bacterial histone-like DNA-binding proteins e.g. Bacillus stearothermophilus SW:DBH_BACST (P02346) (90 aa), Fasta scores: E(): 2e-09, 48.3% identity in 89 aa overlap. Note that the C-terminus is rich in the amino acids Ala, Val and Lys. Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein. Contains PS00045 Bacterial histone-like DNA-binding proteins signature. O33125 No information pathways PF00216 O33125 GO:0007076,GO:0003677 Rv2986c Rv2986c AL450380.2 Mycobrowser_v4 CDS 1124870 1125379 . + 0 ML0956 ML0956 Putative integral membrane protein. ML0956, len: 169 aa. Putative integral membrane protein. Similar to Q9RKN9|AL133220 Streptomyces coelicolor putative membrane protein (180 aa), Fasta scores: E(): 2.8e-13, (43.8% identity in 137 aa overlap). Almost identical to the previously sequenced O05565|Z94723 Mycobacterium leprae hypothetical protein (214 aa), Fasta scores: E(): 0, 100.0% identity in 169 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains a Pfam match to entry PF04173 DoxD-like family. Q9CCC8 No cell wall and cell processes PF07681 Q9CCC8 AL450380.2 Mycobrowser_v4 CDS 1027289 1028863 . - 0 ML0864c pepB Probable cytosol aminopeptidase PepB ML0864c, len: 524 aa. Probable pepB, cytosol aminopeptidase (EC 3.4.11.1). Similar to Mycobacterium tuberculosis probable cytosol aminopeptidase pepA or pepB or Rv2213 or MTCY190.24 SW:AMPA_MYCTU (Q10401) (515 aa) fasta scores: E(): 0, 83.0% identity in 522 aa. Similar to many e.g. Rickettsia prowazekii cytosol aminopeptidase pepA or rp142 SW:AMPA_RICPR (P27888) (500 aa) fasta scores: E(): 0, 39.1% identity in 384 aa. Previously sequenced as TR:O32956 (EMBL:Z98741). Contains Pfam match to entry PF00883 Peptidase_M17, Cytosol aminopeptidase family. Contains PS00631 Cytosol aminopeptidase signature. Belongs to peptidase family M17. O32956 No intermediary metabolism and respiration PF00883,PF02789 O32956 GO:0005737,GO:0030145,GO:0008235,GO:0006508,GO:0004177 3.4.11.1 Rv2213 Rv2213 AL450380.2 Mycobrowser_v4 CDS 1029024 1030127 . + 0 ML0865 gcvT Probable aminomethyltransferase GcvT (Glycine cleavage system T protein) ML0865, len: 367 aa. Probable gcvT, aminomethyltransferase (EC 2.1.2.10). Similar to Mycobacterium tuberculosis probable aminomethyltransferase gcvT or Rv2211c or MTCY190.22 SW:GCST_MYCTU (Q10376) (379 aa) fasta scores: E(): 0, 84.7% identity in 367 aa. Similar to many e.g. Escherichia coli aminomethyltransferase gcvT SW:GCST_ECOLI (P27248) (363 aa) fasta scores: E(): 0, 39.0% identity in 364 aa. Previously sequenced as TR:O32955 (EMBL:Z98741). Contains Pfam match to entry PF01571 GCV_T, Glycine cleavage T-protein (aminomethyl transferase). Belongs to the gcvT family. O32955 No intermediary metabolism and respiration PF01571,PF08669 O32955 GO:0005737,GO:0019464,GO:0008483,GO:0004047 2.1.2.10 Rv2211c Rv2211c AL450380.2 Mycobrowser_v4 CDS 1037609 1039642 . - 0 ML0874c asnB Probable asparagine synthetase [glutamine-hydrolyzing] AsnB ML0874c, len: 677 aa. Probable asnB, asparagine synthetase (EC 6.3.5.4). Similar to Mycobacterium tuberculosis putative asparagine synthetase [glutamine-hydrolyzing] Rv2201 or mtcy190.12 SW:ASNH_MYCTU (Q10374) (652 aa) fasta scores: E(): 0, 83.3% identity in 659 aa and to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 1 asnB or asn SW:ASNB_BACSU (P54420; O34902) (632 aa) fasta scores: E(): 0, 49.0% id in 614 aa. Contains Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains Pfam match to entry PF00733 Asn_synthase, Asparagine synthase. Q9CCF2 No intermediary metabolism and respiration PF00310,PF00733 Q9CCF2 GO:0004066,GO:0006529 6.3.5.4 Rv2201 Rv2201 AL450380.2 Mycobrowser_v4 CDS 1044810 1045994 . - 0 ML0880c qcrA Probable Rieske iron-sulfur protein QcrA (Ubiquinol-cytochrome C reductase iron-sulfur subunit) ML0880c, len: 394 aa. Probable qcrA, Rieske iron-sulfur protein. Similar to Mycobacterium tuberculosis putative ubiquinol-cytochrome C reductase iron-sulfur subunit qcrA or Rv2195 or MTCY190.06 SW:QCRA_MYCTU (Q10387) (429 aa) fasta scores: E(): 0, 80.9% identity in 398 aa. Contains hydrophobic, probable membrane-spanning regions. Contains PS00200 Rieske iron-sulfur protein signature 2. THE MAIN SUBUNITS OF THE UBIQUINOL:CYTOCHROME C COMPLEX ARE: CYTOCHROME B, THE RIESKE PROTEIN AND A CYTOCHROME C SUBUNIT. Q9CCE7 No intermediary metabolism and respiration PF00355 Q9CCE7 GO:0009055,GO:0055114,GO:0016491,GO:0051537 Rv2195 Rv2195 AL450380.2 Mycobrowser_v4 CDS 1519744 1521162 . + 0 ML1277 pykA Probable pyruvate kinase PykA ML1277, len: 472 aa. Probable pyruvate kinase (EC 2.7.1.40). Highly similar to many pyruvate kinases including: Mycobacterium tuberculosis Rv1617 SW:KPYK_MYCTU (O06134) (472 aa), Fasta scores: E(): 0, 90.7% identity in 472 aa overlap and Corynebacterium glutamicum SW:KPYK_CORGL (Q46078) (475 aa), Fasta scores: E(): 0, 71.8% identity in 468 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate kinase active site signature. Q9CC49 No intermediary metabolism and respiration PF00224,PF02887 Q9CC49 GO:0000287,GO:0030955,GO:0004743,GO:0006096 2.7.1.40 Rv1617 Rv1617 AL450380.2 Mycobrowser_v4 CDS 1084524 1086011 . + 0 ML0915 murC Probable UDP-N-acetylmuramate-alanine ligase MurC ML0915, len: 495 aa. Probable murC, UDP-N-acetylmuramate-alanine ligase (EC 6.3.2.8). Identical, over available sequence, to the previously sequenced Mycobacterium leprae UDP-N-acetylmuramate-alanine ligase (fragment) TR:O69551 (EMBL:AL022602) (235 aa), Fasta scores: E(): 0, 99.6% identity in 235 aa overlap. Also highly similar to UDP-N-acetylmuramate-alanine ligases from Mycobacterium tuberculosis SW:MURC_MYCTU (SW:O06225) (494 aa), Fasta scores: E(): 0, 79.8% identity in 494 aa overlap and Escherichia coli SW:MURC_ECOLI (SW:P17952) (491 aa), Fasta scores: E(): 0, 35.2% identity in 477 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Belongs to the murCDEF family. P57994 No cell wall and cell processes PF01225,PF02875,PF08245 P57994 GO:0008763,GO:0007049,GO:0051301,GO:0007047,GO:0005737,GO:0009252,GO:0008360,GO:0005524 6.3.2.8 Rv2152c Rv2152c AL450380.2 Mycobrowser_v4 CDS 1043158 1044813 . - 0 ML0879c qcrB Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) ML0879c, len: 551 aa. Probable qcrB, Ubiquinol-cytochrome C reductase cytochrome B subunit (cytB), integral membrane protein. Similar to Mycobacterium tuberculosis ubiquinol-cytochrome C reductase cytochrome B subunit qcrB or Rv2196 or MTCY190.07 SW:QCRB_MYCTU (Q10388) (549 aa) fasta scores: E(): 0, 92.5% identity in 548 aa and to Streptomyces lividans ubiquinol-cytochrome C reductase cytochrome b subunit qcrB SW:QCRB_STRLI (Q9ZFB6) (549 aa) fasta scores: E(): 0, 44.8% identity in 533 aa. N-terminal half is similar to some cytochomes e.g. Bacillus stearothermophilus menaquinol-cytochrome C reductase cytochrome B subunit qcrB SW:QCRB_BACST (Q45658) (224 aa) fasta scores: E(): 1.1e-13, 27.1% identity in 207 aa. Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N-terminal)/b6/petB. BELONGS TO THE CYTOCHROME B FAMILY. CORRESPONDS TO THE AMINO END OF MITOCHONDRIAL CYTOCHROME B. P15878 No intermediary metabolism and respiration PF00033 P15878 GO:0016021,GO:0005506,GO:0016491,GO:0005886,GO:0022904,GO:0006810,GO:0009055 Rv2196 Rv2196 AL450380.2 Mycobrowser_v4 CDS 1052135 1053289 . + 0 ML0886 ML0886 possible glycosyl transferase. ML0886, len: 384 aa. Possible glycosyl transferase. Similar to Mycobacterium tuberculosis hypothetical protein TR:O53522 (EMBL:AL021957) (385 aa), Fasta scores: E(): 0, 81.5% identity in 383 aa overlap and several Streptomyces coelicolor putative glycosyl transferases e.g. TR:Q9X7Z1 (EMBL:AL049497) (412 aa), Fasta scores: E(): 0, 52.2% identity in 387 aa overlap(EMBL:AL049497). Previously sequenced Mycobacterium leprae hypothetical protein TR:O69579 (EMBL:AL022602) (384 aa), Fasta scores: E(): 0, 99.7% identity in 384 aa overlap(EMBL:AL022602).Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. Q7AQE2 No intermediary metabolism and respiration, lipid metabolism PF00534 Q7AQE2 GO:0016740,GO:0009058 Rv2188c Rv2188c AL450380.2 Mycobrowser_v4 CDS 1071590 1072708 . + 0 ML0906 ML0906 conserved hypothetical protein ML0906, len: 372 aa. Conserved hypothetical protein. Identical over 340 aa to the previously sequenced Mycobacterium leprae hypothetical protein SW:YL65_MYCLE (SW:O69560) (340 aa), Fasta scores: E(): 0, 99.7% identity in 340 aa overlap. Also highly similar to many other proteins of undefined function including: Mycobacterium tuberculosis Rv2165c TR:O06212 (EMBL:Z95388) (396 aa), Fasta scores: E(): 0, 74.2% identity in 376 aa overlap and Escherichia coli SW:YABC_ECOLI (SW:P18595) (313 aa), Fasta scores: E(): 0, 41.6% identity in 298 aa overlap. Contains Pfam match to entry PF01795 DUF36, Domain of unknown function. O69560 No conserved hypotheticals PF01795 O69560 GO:0008168,GO:0005737 2.1.1.- Rv2165c Rv2165c AL450380.2 Mycobrowser_v4 CDS 1076004 1077596 . + 0 ML0909 murE ProbableUDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE ML0909, len: 530 aa. Probable murE, UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (EC 6.3.2.13). Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) SW:MURE_MYCLE (AL022602) (530 aa), Fasta scores: E(): 0, 99.8% identity in 530 aa overlap. Also highly similar to MurE orthologues from Mycobacterium tuberculosis SW:MURE_MYCTU (O06219) (535 aa), Fasta scores: E(): 0, 74.4% identity in 519 aa overlap and Escherichia coli SW:MURE_ECOLI (P22188) (494 aa), Fasta scores: E(): 0, 39.1% identity in 493 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Belongs to the murCDEF family. O69557 No cell wall and cell processes PF01225,PF02875,PF08245 O69557 GO:0008765,GO:0007049,GO:0051301,GO:0007047,GO:0005737,GO:0009252,GO:0008360,GO:0005524 6.3.2.13 Rv2158c Rv2158c AL450380.2 Mycobrowser_v4 CDS 1073835 1075862 . + 0 ML0908 pbpB Probable penicillin-binding membrane protein PbpB ML0908, len: 675 aa. Probable pbpB, penicillin-binding membrane protein. Identical to the previously sequenced Mycobacterium leprae penicillin binding protein 2 TR:O69558 (EMBL:AL022602) (675 aa), Fasta scores: E(): 0, 99.9% identity in 675 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2163c TR:O06214 (EMBL:Z95388) (679 aa), Fasta scores: E(): 0, 80.6% identity in 677 aa overlap(EMBL:Z95388) and to many other penicillin-binding proteins e.g. Neisseria meningitidis SW:PBP2_NEIME (P11882) (581 aa), Fasta scores: E(): 4.3e-29, 32.4% identity in 590 aa overlap(P11882). Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O69558 No cell wall and cell processes PF00905,PF03717 O69558 GO:0009273,GO:0008658 Rv2163c Rv2163c AL450380.2 Mycobrowser_v4 CDS 1127780 1130062 . - 0 ML0961c metE CATALYZES THE TRANSFER OF A METHYL GROUP FROM 5-METHYLTETRAHYDROFOLATE TO HOMOCYSTEINE RESULTING IN METHIONINE FORMATION (PATHWAY: TERMINAL STEP IN THE DE NOVO BIOSYNTHESIS OF METHIONINE) [CATALYTIC ACTIVITY : 5-METHYLTETRAHYDROPTEROYLTRI-L-GLUTAMATE + L- HOMOCYSTEINE = TETRAHYDROPTEROYLTRI-L-GLUTAMATE + L-METHIONINE.] PROBABLE5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE METE (methionine synthase, vitamin-B12 independent isozyme) ML0961c, len: 760 aa. Probable metE, 5-methyltetrahydropteroyltriglutamate-homocystein methyltransferase (EC 2.1.1.14). Identical to the previously sequenced Mycobacterium leprae 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) SW:METE_MYCLE (O05564) (760 aa), Fasta scores: E(): 0, 100.0% identity in 760 aa overlap. Also highly similar to MetE orthologues from Mycobacterium tuberculosis Rv1133c SW:METE_MYCTU (O06584) (759 aa), Fasta scores: E(): 0, 85.0% identity in 759 aa overlap and Escherichia coli SW:METE_ECOLI (P25665) (752 aa), Fasta scores: E(): 0, 47.5% identity in 754 aa overlap. Contains Pfam match to entry PF01717 Methionine_synt, Methionine synthase, vitamin-B12 independent. BELONGS TO THE VITAMIN-B12 INDEPENDENT METHIONINE SYNTHASE FAMILY. O05564 No intermediary metabolism and respiration PF01717,PF08267 O05564 GO:0009086,GO:0008270,GO:0003871 2.1.1.14 Rv1133c Rv1133c AL450380.2 Mycobrowser_v4 CDS 1153059 1155194 . + 0 ML0987 recA INVOLVED IN REGULATION OF NUCLEOTIDE EXCISION REPAIR, IN GENETIC RECOMBINATION, AND IN INDUCTION OF THE SOS RESPONSE. ENDONUCLEASE WHICH CAN CATALYZE THE HYDROLYSIS OF ATP IN THE PRESENCE OF SINGLE-STRANDED DNA, THE ATP-DEPENDENT UPTAKE OF SINGLE-STRANDED DNA BY DUPLEX DNA, AND THE ATP-DEPENDENT HYBRIDIZATION OF HOMOLOGOUS SINGLE-STRANDED DNAS. IT INTERACTS WITH LEXA CAUSING ITS ACTIVATION AND LEADING TO ITS AUTOCATALYTIC CLEAVAGE. RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. ML0987, len: 711 aa. Probable RecA protein (EC 3.1.-.-). Identical to the previously sequenced and characterised Mycobacterium leprae RecA protein involved in DNA recombination and the SOS response SW:RECA_MYCLE (P35901) (711 aa), Fasta scores: E(): 0, 100.0% identity in 711 aa overlap. Also highly similar to many others e.g. Mycobacterium tuberculosis Rv2737c SW:RECA_MYCTU (P26345) (790 aa), Fasta scores: E(): 0, 46.7% identity in 814 aa overlap. Note the Mycobacterium leprae RecA protein is known to possess an intron which is self-spliced at the post-translational level. Contains 2 Pfam matches to entry PF00154 recA, recA bacterial DNA recombination proteins. Contains PS00321 recA signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00881 Protein splicing signature. Belongs to the recA family. P35901 No information pathways PF00154,PF03161 P35901 GO:0006310,GO:0006281,GO:0008094,GO:0009432,GO:0005737,GO:0003684,GO:0004519,GO:0016539,GO:0003697,GO:0005524 Rv2737c Rv2737c AL450380.2 Mycobrowser_v4 CDS 1172922 1174985 . + 0 ML1002 ML1002 Possible conserved transmembrane protein ML1002, len: 687 aa. Possible conserved transmembrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49837 (EMBL:U00019) (687 aa), Fasta scores: E(): 0, 99.9% identity in 687 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2721c TR:O07219. Contains a possible membrane spanning hydrophobic domain. Q7AQB6 No cell wall and cell processes PF08310 Q7AQB6 Rv2721c Rv2721c AL450380.2 Mycobrowser_v4 CDS 1176011 1176505 . + 0 ML1004 ML1004 possible conserved membrane protein ML1004, len: 164 aa. Possible conserved membrane protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49846 (EMBL:U00019) (164 aa), Fasta scores: E(): 0, 100.0% identity in 164 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2719c TR:O07218 (EMBL:Z96072) (165 aa), Fasta scores: E(): 1.8e-23, 55.2% identity in 163 aa overlap. Contains a possible membrane spanning hydrophobic domain. Q7AQB5 No cell wall and cell processes PF01476 Q7AQB5 GO:0016998 Rv2719c Rv2719c AL450380.2 Mycobrowser_v4 CDS 1176667 1177131 . + 0 ML1005 ML1005 conserved hypothetical protein ML1005, len: 154 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49844 (EMBL:U00019) (154 aa), Fasta scores: E(): 0, 100.0% identity in 154 aa overlap. Also highly similar to a number of other proteins of unknown function e.g. Mycobacterium tuberculosis Rv2718c TR:O07217 (EMBL:Z96072) (154 aa), Fasta scores: E(): 0, 92.7% identity in 151 aa overlap and Escherichia coli SW:YBAD_ECOLI (P25538) (149 aa), Fasta scores: E(): 9.7e-21, 45.6% identity in 147 aa overlap. Belongs to the UPF0168 family. Q49844 No conserved hypotheticals, regulatory proteins PF03477 Q49844 GO:0003677,GO:0006355,GO:0006350,GO:0016564,GO:0008270,GO:0005524 Rv2718c Rv2718c AL450380.2 Mycobrowser_v4 CDS 1191846 1192721 . + 0 ML1024 suhB possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). ML1024, len: 291 aa. Possible subH, inositol monophosphatase. Identical to the previously sequenced Mycobacterium leprae extragenic suppressor protein SuhB homologue SW:SUHB_MYCLE (P46813) (291 aa), Fasta scores: E(): 0, 99.7% identity in 291 aa overlap. Also highly similar to many other members of the inositol monophosphatase family including: Mycobacterium tuberculosis, Rv2701c SW:SUHB_MYCTU (O07203) (290 aa), Fasta scores: E(): 0, 77.6% identity in 294 aa overlap and Escherichia coli ShuB, SW:SUHB_ECOLI (P22783) (267 aa), Fasta scores: E(): 1.6e-18, 34.7% identity in 239 aa overlap, shown to suppress the effect of a temperature-sensitive mutation in E. coli. Note the predicted translational start site for this CDS maybe incorrect due to the overlap with CDS ML1023. Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family. Contains PS00629 Inositol monophosphatase family signature 1. Contains PS00630 Inositol monophosphatase family signature 2. Belongs to the inositol monophosphatase family. P46813 No virulence, detoxification, adaptation, intermediary metabolism and respiration PF00459 P46813 GO:0000287,GO:0008934 3.1.3.25 Rv2701c Rv2701c AL450380.2 Mycobrowser_v4 CDS 1194377 1194841 . + 0 ML1028 dut INVOLVED IN BIOSYNTHESIS OF THYMIDYLATE. THIS ENZYME IS INVOLVED IN NUCLEOTIDE METABOLISM: IT PRODUCES DUMP, THE IMMEDIATE PRECURSOR OF THYMIDINE NUCLEOTIDES AND IT DECREASES THE INTRACELLULAR CONCENTRATION OF DUTP SO THAT URACIL CANNOT BE INCORPORATED INTO DNA [CATALYTIC ACTIVITY: DUTP + H(2)O = DUMP + PYROPHOSPHATE]. PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE DUT (DUTPASE) (DUTP PYROPHOSPHATASE) (DEOXYURIDINE 5'-TRIPHOSPHATASE) (DUTP DIPHOSPHATASE) (DEOXYURIDINE-TRIPHOSPHATASE) ML1028, len: 154 aa. Probable dut, deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23). Identical to the previously sequenced Mycobacterium leprae deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) SW:DUT_MYCLE (Q49992) (155 aa), Fasta scores: E(): 0, 100.0% identity in 154 aa overlap. Also highly similar to many other dUTPases, involved in nucleotide metabolism, including Mycobacterium tuberculosis SW:DUT_MYCTU (O07199) (154 aa), Fasta scores: E(): 0, 90.3% identity in 154 aa overlap and Escherichia coli SW:DUT_ECOLI (P06968) (461 aa), BlastP Expect 8.8. Contains Pfam match to entry PF00692 dUTPase, dUTPase. BELONGS TO THE DUTPASE FAMILY. Q49992 No intermediary metabolism and respiration PF00692 Q49992 GO:0046080,GO:0004170 3.6.1.23 Rv2697c Rv2697c AL450380.2 Mycobrowser_v4 CDS 1208220 1209293 . + 0 ML1043 hemE PROBABLE UROPORPHYRINOGEN DECARBOXYLASE HEME (UROPORPHYRINOGEN III DECARBOXYLASE) (URO-D) (UPD) ML1043, len: 357 aa. Probable hemE, uroporphyrinogen decarboxylase (EC 4.1.1.37). Identical to the previously sequenced Mycobacterium leprae uroporphyrinogen decarboxylase (EC 4.1.1.37) SW:DCUP_MYCLE (P46809) (357 aa), Fasta scores: E(): 0, 100.0% identity in 357 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis SW:DCUP_MYCTU (O53231) (357 aa), Fasta scores: E(): 0, 83.8% identity in 357 aa overlap and Bacillus subtilis SW:DCUP_BACSU (P32395) (353 aa), Fasta scores: E(): 0, 43.5% identity in 354 aa overlap. Contains Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D). Contains PS00907 Uroporphyrinogen decarboxylase signature 2. Contains PS00906 Uroporphyrinogen decarboxylase signature 1. Belongs to the uroporphyrinogen decarboxylase family. P46809 No intermediary metabolism and respiration PF01208 P46809 GO:0006779,GO:0004853,GO:0005737 4.1.1.37 Rv2678c Rv2678c AL450380.2 Mycobrowser_v4 CDS 1210651 1211346 . + 0 ML1045 ML1045 conserved hypothetical protein ML1045, len: 696 aa. Conserved hypothetical protein. Identical, apart from N-terminus, to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q50009 (EMBL:U15181) (297 aa), Fasta scores: E(): 0, 100.0% identity in 231 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv2676c TR:P71973 (EMBL:Z80225) (231 aa), Fasta scores: E(): 0, 87.4% identity in 231 aa overlap and Streptomyces coelicolor TR:O69830 (EMBL:AL023517) (243 aa), Fasta scores: E(): 0, 61.3% identity in 222 aa overlap. Q9CCB2 No conserved hypotheticals PF06778 Q9CCB2 Rv2676c Rv2676c AL450380.2 Mycobrowser_v4 CDS 1218565 1219830 . - 0 ML1052c ML1052c conserved hypothetical protein ML1052c, len: 421 aa. Conserved hypothetical protein. Previously sequenced Mycobacterium leprae hypothetical protein TR:Q50018 (EMBL:U15181) (517 aa), Fasta scores: E(): 0, 100.0% identity in 421 aa overlap. Also highly similar to several hypothetical proteins from Mycobacterium tuberculosis e.g. Rv1194c TR:O05296 (EMBL:Z93777) (421 aa), Fasta scores: E(): 0, 70.1% identity in 421 aa overlap. Q9CCB1 No conserved hypotheticals Q9CCB1 Rv1194c Rv1194c AL450380.2 Mycobrowser_v4 CDS 1230988 1231566 . + 0 ML1066 tagA PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I ) ML1066, len: 192 aa. Probable tagA, DNA-3-methyladenine glycosidase I (EC 3.2.2.20). Identical to the previously sequenced Mycobacterium leprae TR:Q49957 (EMBL:U15180) (192 aa), Fasta scores: E(): 0, 99.5% identity in 192 aa overlap. Also highly similar to DNA-3-methyladenine glycosidases from Mycobacterium tuberculosis Rv1210 TR:O05311 (EMBL:Z93777) (204 aa), Fasta scores: E(): 0, 80.2% identity in 192 aa overlap and Escherichia coli SW:3MG1_ECOLI (P05100) (187 aa), Fasta scores: E(): 1.8e-27, 43.8% identity in 185 aa overlap. Q49957 No information pathways PF03352 Q49957 GO:0006284,GO:0008725 Rv1210 Rv1210 AL450380.2 Mycobrowser_v4 CDS 1239343 1240134 . + 0 ML1076 sigE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGE ML1076, len: 263 aa. sigE, alternative sigma factor of extracytoplasmic function (ECF) family. Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE Rv1221 TR:O06289 (EMBL:U87242) (257 aa), Fasta scores: E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa), Fasta scores: E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa), Fasta scores: E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a possible helix-turn-helix motif situated between residues 213..234 (+3.09 SD). Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Q9CCA6 No information pathways PF04542,PF08281 Q9CCA6 GO:0016987,GO:0003700,GO:0006352,GO:0006355 Rv1221 Rv1221 AL450380.2 Mycobrowser_v4 CDS 1253342 1254451 . - 0 ML1090c corA POSSIBLE MAGNESIUM AND COBALT TRANSPORT TRANSMEMBRANE PROTEIN CORA ML1090c, len: 369 aa. Possible corA, magnesium and cobalt transport transmembrane protein. Previously sequenced Mycobacterium leprae TR:Q49979 (EMBL:U15180) (373 aa), Fasta scores: E(): 0, 100.0% identity in 369 aa overlap. Highly similar to Mycobacterium tuberculosis magnesium and cobalt transport protein, CorA (Rv1239c) TR:O50455 (EMBL:AL021006) (366 aa), Fasta scores: E(): 0, 79.4% identity in 369 aa overlap. Also weakly similar to Haemophilus influenzae SW:CORA_HAEIN (P44998) (315 aa), Fasta scores: E(): 2.8e-07, 24.1% identity in 323 aa overlap, CorA transporter. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01544 CorA, CorA-like Mg2+ transporter protein. Q9CCA0 No cell wall and cell processes PF01544 Q9CCA0 GO:0006824,GO:0015095,GO:0015693,GO:0016020,GO:0015087 Rv1239c Rv1239c AL450380.2 Mycobrowser_v4 CDS 1272635 1273774 . + 0 ML1101 ML1101 PROBABLE ACYLTRANSFERASE ML1101, len: 379 aa. Probable acyltransferase (EC 2.3.1.-). Similar to several acyltransferases including: Streptomyces thermotolerans macrolide antibiotics 3-O-acyltransferase TR:Q56074 (EMBLD30759:) (389 aa), Fasta scores: E(): 1.3e-14, 29.4% identity in 377 aa overlap and Mycobacterium tuberculosis probable acyltransferase Rv1254 TR:Q11064 (EMBL:Z77137) (383 aa), Fasta scores: E(): 0, 79.6% identity in 378 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q9CC93 No intermediary metabolism and respiration PF01757 Q9CC93 GO:0008415 Rv1254 Rv1254 AL450380.2 Mycobrowser_v4 CDS 1289626 1291380 . - 0 ML1114c ML1114c PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER ML1114c, len: 584 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter. Highly similar to many proposed ABC transporter proteins including: Mycobacterium tuberculosis Rv1273c SW:YC73_MYCTU (Q11046) (582 aa), Fasta scores: E(): 0, 78.4% identity in 583 aa overlap and Bacillus subtilis hypothetical ABC transporter ATP-binding protein SW:YFIB_BACSU (P54718) (573 aa), Fasta scores: E(): 0, 34.4% identity in 569 aa overlap. Also similar to the adjoining CDS ML1113c. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Q9CC88 No cell wall and cell processes PF00005,PF00664 Q9CC88 GO:0006810,GO:0005524,GO:0042626,GO:0016021 Rv1273c Rv1273c AL450380.2 Mycobrowser_v4 CDS 1299723 1301396 . - 0 ML1121c oppA PROBABLE PERIPLASMIC OLIGOPEPTIDE-BINDING LIPOPROTEIN OPPA ML1121c, len: 557 aa. Probable oppA, oligopeptide-binding lipoprotein component of peptide transport system. Similar to several including: Mycobacterium tuberculosis extracellular solute-binding Rv1280c SW:YC80_MYCTU (Q11041) (591 aa), Fasta scores: E(): 0, 80.3% identity in 548 aa overlap and Escherichia coli putative binding protein YddS precursor SW:YDDS_ECOLI (P76128) (516 aa), Fasta scores: E(): 2.3e-10, 22.5% identity in 480 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 5. Q9CC82 No cell wall and cell processes PF00496 Q9CC82 GO:0005215,GO:0006810 Rv1280c Rv1280c AL450380.2 Mycobrowser_v4 CDS 1316574 1318226 . + 0 ML1127 argS PROBABLE ARGINYL-TRNA SYNTHETASE ARGS (ARGRS) (Arginine--tRNA ligase) ML1127, len: 550 aa. Probable argS, arginyl-tRNA synthase (EC 6.1.1.19). Identical to the previously sequenced Mycobacterium leprae arginyl-tRNA synthetase (arginine--tRNA ligase) SW:SYR_MYCLE (P45840) (550 aa), Fasta scores: E(): 0, 99.6% identity in 550 aa overlap. Also highly similar to many other arginyl-tRNA synthetases including: Mycobacterium tuberculosis Rv1292 SW:SYR_MYCTU (Q10609) (550 aa), Fasta scores: E(): 0, 84.9% identity in 550 aa overlap and Brevibacterium lactofermentum SW:SYR_BRELA (P41253) (550 aa), Fasta scores: E(): 0, 63.8% identity in 550 aa overlap. Contains Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. P45840 No information pathways PF00750,PF03485,PF05746 P45840 GO:0004814,GO:0006420,GO:0005737,GO:0005524 6.1.1.19 Rv1292 Rv1292 AL450380.2 Mycobrowser_v4 CDS 2762496 2762933 . - 0 ML2332c ML2332c conserved hypothetical protein ML2332c, len: 145 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 15.7 kDa protein Rv3718c TR:O69685 (EMBL:AL022121) (147 aa) fasta scores: E(): 0, 81.9% identity in 144 aa and Streptomyces coelicolor conserved hypothetical protein TR:Q9ZBJ2 (EMBL:AL035161) (147 aa) fasta scores: E(): 1.4e-22, 47.6% identity in 147 aa. Q7APW4 No conserved hypotheticals PF10604 Q7APW4 Rv3718c Rv3718c AL450380.2 Mycobrowser_v4 CDS 1331274 1331519 . + 0 ML1140 atpE PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) ML1140, len: 81 aa. Probable atpE, ATP synthase C chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase C chain protein SW:ATPL_MYCLE (P45828) (81 aa), Fasta scores: E(): 1.1e-25, 100.0% identity in 81 aa overlap. Also highly similar to many other Prokaryotic and Eukaryotic proposed ATPase C chain family proteins e.g. Mycobacterium tuberculosis Rv1305 SW:ATPL_MYCTU (Q10598) (81 aa), Fasta scores: E(): 6.4e-24, 92.6% identity in 81 aa overlap and Euglena gracilis SW:ATPH_EUGGR (P10603) (81 aa), Fasta scores: E(): 4.8e-06, 36.7% identity in 79 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00137 ATP-synt_C, ATP synthase subunit C. Contains PS00605 ATP synthase c subunit signature. P45828 No intermediary metabolism and respiration PF00137 P45828 GO:0046933,GO:0016021,GO:0008289,GO:0005886,GO:0045263,GO:0015986 Rv1305 Rv1305 AL450380.2 Mycobrowser_v4 CDS 1336078 1337535 . + 0 ML1145 atpD PROBABLE ATP SYNTHASE BETA CHAIN ATPD ML1145, len: 485 aa. Probable atpD, ATP synthase [beta] chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase beta chain (EC 3.6.1.34) SW:ATPB_MYCLE (P45823) (485 aa), Fasta scores: E(): 0, 100.0% identity in 485 aa overlap. Also highly similar to many other proposed ATPase beta chain family proteins e.g. Mycobacterium tuberculosis Rv1310 SW:ATPB_MYCTU (Q10593) (486 aa), Fasta scores: E(): 0, 92.6% identity in 484 aa overlap and Streptomyces lividan SW:ATPB_STRLI (P50004) (477 aa), Fasta scores: E(): 0, 70.3% identity in 478 aa overlap. Contains Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family. Contains Pfam match to entry PF00306 ATP-synt_ab_C, ATP synthase ab C terminal. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00152 ATP synthase alpha and beta subunits signature. P45823 No intermediary metabolism and respiration PF00006,PF00306,PF02874 P45823 GO:0046933,GO:0008553,GO:0005886,GO:0042777,GO:0045261,GO:0046961,GO:0005524 3.6.3.14 Rv1310 Rv1310 AL450380.2 Mycobrowser_v4 CDS 3128842 3131709 . - 0 ML2620c mmpL3 POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL3 ML2620c, len: 955 aa. Possible mmpl3, conserved transmembrane transport protein. Similar to many Mycobacterium tuberculosis mmp-family membrane proteins e.g. Mmpl3 OR Rv0206c SW:MML3_MYCTU (O53657) fasta scores: E(): 0, 75.7% identity in 966 aa, and to Streptomyces coelicolor putative membrane transport protein SCF51A.01C TR:Q9RL63 (EMBL:AL121596) fasta scores: E(): 0, 28.8% identity in 791 aa. Also similar to ML2617 from M. leprae. Contains multiple possible membrane spanning hydrophobic domains. O06081 No cell wall and cell processes PF03176 O06081 GO:0005886,GO:0016021 Rv0206c Rv0206c AL450380.2 Mycobrowser_v4 CDS 1346363 1346860 . - 0 ML1151c ogt REPAIR OF ALKYLATED GUANINE IN DNA BY STOICHIOMETRICALLY TRANSFERRING THE ALKYL GROUP AT THE O-6 POSITION TO A CYSTEINE RESIDUE IN THE ENZYME. THIS IS A SUICIDE REACTION: THE ENZYME IS IRREVERSIBLY INACTIVATED [CATALYTIC ACTIVITY : DNA (CONTAINING 6-O-METHYLGUANINE) + [PROTEIN]-L-CYSTEINE = DNA (WITHOUT 6-O-METHYLGUANINE) + PROTEIN S-METHYL-L-CYSTEINE.] PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase) ML1151c, len: 165 aa. Probable methylated-DNA-protein-cysteine methyltransferase (EC 2.1.1.63). Identical to the previously sequenced Mycobacterium leprae putative methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) SW:OGT_MYCLE (P52982) (165 aa), Fasta scores: E(): 0, 100.0% identity in 165 aa overlap. Also highly similar to many others e.g. Mycobacterium tuberculosis Rv1316c SW:OGT_MYCTU (Q10627) (165 aa), Fasta scores: E(): 0, 78.2% identity in 165 aa overlap and Bacillus subtilis SW:OGT_BACSU (P11742) (165 aa), Fasta scores: E(): 1e-20, 44.7% identity in 159 aa overlap. Contains Pfam match to entry PF01035 Methyltransf_1, 6-O-methylguanine DNA methyltransferase. Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. P52982 No information pathways PF01035,PF02870 P52982 GO:0003908,GO:0006281 2.1.1.63 Rv1316c Rv1316c AL450380.2 Mycobrowser_v4 CDS 1352356 1352823 . - 0 ML1157c ML1157c conserved hypothetical protein ML1157c, len: 155 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae TR:Q49717 (EMBL:U00014) (155 aa), Fasta scores: E(): 0, 99.4% identity in 155 aa overlap. Similar to Q8VK36 Conserved hypothetical protein from M. tuberculosis (152 aa), fasta scores: E(): 2.8e-47, 74.675% identity in 154 aa overlap and Streptomyces coelicolor conserved hypothetical protein TR:CAB70628 (EMBL:AL137242) (146 aa), Fasta scores: E(): 1.5e-19, 42.1% identity in 140 aa overlap. Contains Pfam match to entry PF01626 4HPPD_C, 4-hydroxyphenylpyruvate dioxygenase C terminal domain. Q7AQ90 No conserved hypotheticals PF00903 Q7AQ90 Rv1322A Rv1322A AL450380.2 Mycobrowser_v4 CDS 2027720 2028655 . + 0 ML1682 mutT1 POSSIBLE HYDROLASE MUTT1 ML1682, len: 311 aa. Possible mutT1 hydrolase. Similar to Mycobacterium tuberculosis TR:P95110 (EMBL:Z83018) Rv2985 (317 aa), Fasta scores: E(): 0, 71.5% identity in 316 aa overlap and Streptomyces coelicolor putative MutT-like protein TR:CAB88476 (EMBL:AL353816) (142 aa), Fasta scores: E(): 2.6e-17, 47.7% identity in 128 aa overlap. Contains Pfam match to entry PF00293 mutT, Bacterial mutT protein. Contains PS00893 mutT domain signature. Q9CBR8 No information pathways PF00293,PF00300 Q9CBR8 GO:0016787 Rv2985 Rv2985 AL450380.2 Mycobrowser_v4 CDS 1365554 1366642 . + 0 ML1167 ML1167 PROBABLE HYDROLASE ML1167, len: 362 aa. Probable Hydrolase. Previously sequenced Mycobacterium leprae hypothetical protein SW:YD33_MYCLE (P53425) (362 aa), Fasta scores: E(): 0, 100.0% identity in 362 aa overlap. Similar to Mycobacterium tuberculosis Rv1333 TR:YD33_MYCTU Q10644 Probable Hydrolase (344 aa), fasta scores: E(): 3.1e-97, (76.705% identity in 352 aa overlap); and Streptomyces coelicolor TR:CAB90977 (EMBL:AL355832) Hypothetical protein (348 aa), Fasta scores: E(): 0, (48.2% identity in 365 aa overlap); and Flavobacterium sp. TR:Q57326 (EMBL:D26094) endo-type 6-aminohexanoate oligomer hydrolase (355 aa), Fasta scores: E(): 1.4e-11, 31.6% identity in 351 aa overlap. P53425 No intermediary metabolism and respiration PF03576 P53425 GO:0005886,GO:0016021 Rv1333 Rv1333 AL450380.2 Mycobrowser_v4 CDS 1369208 1370026 . + 0 ML1172 murI PROBABLE GLUTAMATE RACEMASE MURI ML1172, len: 272 aa. Probable glutamate racemase (EC 5.1.1.3). Identical to the previously sequenced Mycobacterium leprae probable glutamate racemase (EC 5.1.1.3) SW:MURI_MYCLE (P46705) (272 aa), Fasta scores: E(): 0, 100.0% identity in 272 aa overlap. Also highly similar to many others involved in peptidoglycan biosynthesis including glutamate racemases from Mycobacterium tuberculosis Rv1338 SW:MURI_MYCTU (Q10626) (271 aa), Fasta scores: E(): 0, 88.9% identity in 271 aa overlap and Bacillus subtilis SW:MURI_BACSU (P94556) (272 aa), Fasta scores: E(): 0, 42.2% identity in 268 aa overlap. Contains Pfam match to entry PF01177 Asp_Glu_race, Aspartate / glutamate racemase. Contains PS00924 Aspartate and glutamate racemases signature 2. Contains PS00923 Aspartate and glutamate racemases signature 1. P46705 No cell wall and cell processes PF01177 P46705 GO:0008881,GO:0009252,GO:0008360,GO:0007047 5.1.1.3 Rv1338 Rv1338 AL450380.2 Mycobrowser_v4 CDS 3176736 3177233 . + 0 ML2654 ML2654 conserved hypothetical protein ML2654, len: 165 aa. Conserved hypothetical protein. Similar to many proteins of undefined function e.g. Streptomyces coelicolor hypothetical 18.3 kda protein TR:Q9RJE5 (EMBL:AL133171) fasta scores: E(): 0, 60.1% in 163 aa. Contains Pfam match to entry PF01143 UPF0025, Uncharacterized protein family UPF0025. Q9CCZ0 No conserved hypotheticals PF00149 Q9CCZ0 GO:0016787 AL450380.2 Mycobrowser_v4 CDS 1396625 1405855 . + 0 ML1191 fas PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) ML1191, len: 3076 aa. Probable fas, fatty acid synthase (EC 2.3.1.-). Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa), Fasta scores: E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa), Fasta scores: E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa), Fasta scores: E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q9X7E2 No lipid metabolism PF00109,PF00698,PF01575,PF02801,PF08354 Q9X7E2 GO:0006633,GO:0005835,GO:0004312,GO:0016491,GO:0005488 Rv2524c Rv2524c AL450380.2 Mycobrowser_v4 CDS 1417032 1417637 . + 0 ML1199 lspA THIS PROTEIN SPECIFICALLY CATALYZES THE REMOVAL OF SIGNAL PEPTIDES FROM PROLIPOPROTEINS [CATALYTIC ACTIVITY : CLEAVAGE OF N-TERMINAL LEADER SEQUENCES FROM MEMBRANE PROLIPOPROTEINS. HYDROLYSES XAA-XBB-XBB-|-CYS, IN WHICH XAA IS HYDROPHOBIC (PREFERABLY LEU), XBB IS OFTEN SER OR ALA, XCC IS OFTEN GLY OR ALA, AND THE CYS IS ALKYLATED ON SULFUR WITH A DIACYLGLYCERYL GROUP]. PROBABLE LIPOPROTEIN SIGNAL PEPTIDASE LSPA ML1199, len: 201 aa. Probable lspA, lipoprotein signal peptidase (EC 3.4.23.36). Identical to the previously sequenced Mycobacterium leprae lipoprotein signal peptidase TR:Q9X7E7 (EMBL:AL049478) (201 aa), Fasta scores: E(): 0, 100.0% identity in 201 aa overlap. Also highly similar to lipoprotein signal peptidases from: Mycobacterium tuberculosis Rv1539 SW:LSPA_MYCTU (Q10764) (202 aa), Fasta scores: E(): 0, 80.6% identity in 201 aa overlap and Bacillus subtilis SW:LSPA_BACSU (Q45479) (154 aa), Fasta scores: E(): 1.2e-12, 36.8% identity in 163 aa overlap. Contains Pfam match to entry PF01252 Peptidase_A8, Signal peptidase (SPase) II. Contains PS00855 Signal peptidases II signature. Q9X7E7 No cell wall and cell processes PF01252 Q9X7E7 GO:0016021,GO:0005886,GO:0006508,GO:0004190 3.4.23.36 Rv1539 Rv1539 AL450380.2 Mycobrowser_v4 CDS 1434682 1436883 . - 0 ML1213c ML1213c CONSERVED HYPOTHETICAL MEMBRANE PROTEIN ML1213c, len: 733 aa. Conserved hypothetical membrane protein. Previously sequenced Mycobacterium leprae putative membrane protein (fragment) TR:Q9X7F3 (EMBL:AL049478) (274 aa), Fasta scores: E(): 0, 100.0% identity in 274 aa overlap. Also similar to a number of Prokaryotic and Eukaryotic proteins of undefined function including: Mycobacterium tuberculosis Rv1565c TR:O06625 (EMBL:Z95586) (729 aa), Fasta scores: E(): 0, 76.5% identity in 729 aa overlap and Caenorhabditis elegans TR:O62230 (EMBL:Z81528) (698 aa), Fasta scores: E(): 5.2e-09, 24.8% identity in 646 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q9CC68 No cell wall and cell processes PF01757 Q9CC68 GO:0016747 Rv1565c Rv1565c AL450380.2 Mycobrowser_v4 CDS 1439917 1441074 . + 0 ML1217 bioF PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE) ML1217, len: 385 aa. Probable bioF1, 8-amino-7-oxononanoate synthase (EC 2.3.1.47)Identical to the previously sequenced Mycobacterium leprae 8-amino-7-oxononanoate synthase (EC 2.3.1.47) SW:BIOF_MYCLE (P45487) (385 aa), Fasta scores: E(): 0, 100.0% identity in 385 aa overlap. Also highly similar to many othes e.g. Escherichia coli SW:BIOF_ECOLI (P12998) (384 aa), Fasta scores: E(): 0, 36.9% identity in 379 aa overlap, involved in biotin biosynthesis, and Mycobacterium tuberculosis Rv1569 SW:BIOF_MYCTU (O06621) (386 aa), Fasta scores: E(): 0, 80.1% identity in 381 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. P45487 No intermediary metabolism and respiration PF00155 P45487 GO:0009102,GO:0030170,GO:0016769,GO:0008710 2.3.1.47 Rv1569 Rv1569 AL450380.2 Mycobrowser_v4 CDS 1446716 1447774 . + 0 ML1225 nadA Probable quinolinate synthetase A NadA ML1225, len: 352 aa. Probable nadA, quinolinate synthetase. Identical to the previously sequenced Mycobacterium leprae probable quinolinate synthetase A TR:Q49622 (EMBL:U00010) (368 aa), Fasta scores: E(): 0, 100.0% identity in 352 aa overlap. Also similar to quinolinate synthetases from Escherichia coli SW:NADA_ECOLI (P11458) (347 aa), Fasta scores: E(): 2.6e-27, 33.3% identity in 330 aa overlap and Mycobacterium tuberculosis Rv1594 TR:O06596 (EMBL:Z95586) (349 aa), Fasta scores: E(): 0, 84.4% identity in 352 aa overlap. Belongs to the quinolinate synthetase A family. Subfamily 2. Q49622 No intermediary metabolism and respiration PF02445 Q49622 GO:0009435,GO:0005737,GO:0005506,GO:0008987,GO:0016740,GO:0051539 2.5.1.72 Rv1594 Rv1594 AL450380.2 Mycobrowser_v4 CDS 2884103 2884711 . - 0 ML2413c ML2413c Possible phosphoglycerate mutase ML2413c, len: 202 aa. Possible phosphoglycerate mutase (EC 5.4.2.1). Similar to Mycobacterium tuberculosis conserved hypothetical protein Rv0525 TR:O06391 (EMBL:Z95558) (202 aa) fasta scores: E(): 0, 82.5% identity in 200 aa, and to Escherichia coli probable phosphoglycerate mutase SW:PMG2_ECOLI (P36942) (215 aa) fasta scores: E(): 0.002, 26.1% identity in 184 aa. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Q7APU9 No intermediary metabolism and respiration, conserved hypotheticals PF00300 Q7APU9 Rv0525 Rv0525 AL450380.2 Mycobrowser_v4 CDS 1447771 1449354 . + 0 ML1226 nadB QUINOLINATE BIOSYNTHESIS. CATALYZES THE OXIDATION OF L-ASPARTATE TO IMINOASPARTATE WHICH IS CONDENSED WITH DIHYDROXYACETONE PHOSPHATE TO QUINOLINATE UNDER THE ACTION OF QUINOLINATE SYNTHASE A [CATALYTIC ACTIVITY : L-ASPARTATE + H(2)O + O(2) = OXALOACETATE + NH(3) + H(2)O(2)] Probable L-aspartate oxidase NadB ML1226, len: 286 aa. Probable nadB, L-aspartate oxidase (EC 1.4.3.16). Previously sequenced Mycobacterium leprae L-aspartate oxidase SW:NADB_MYCLE (Q49617) (424 aa), Fasta scores: E(): 0, 99.8% identity in 400 aa overlap. Note ML1226 differs in length from that previously sequenced, possibly due to a frameshift in the original sequence. Highly similar to several proteins involved in quinolinate biosynthesis e.g. Mycobacterium tuberculosis Rv1595 SW:NADB_MYCTU (O06595) (527 aa), Fasta scores: E(): 0, 76.7% identity in 529 aa overlap and Escherichia coli SW:NADB_ECOLI (P10902) (540 aa), Fasta scores: E(): 6.2e-31, 38.8% identity in 533 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. Q49617 No intermediary metabolism and respiration PF00890,PF02910 Q49617 GO:0009435,GO:0005737,GO:0009055,GO:0055114,GO:0008734 1.4.3.16 Rv1595 Rv1595 AL450380.2 Mycobrowser_v4 CDS 1460739 1462154 . + 0 ML1230 papA3 PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3 ML1230, len: 471 aa. Probable papA3, conserved polyketide synthase associated protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49618 (EMBL:U00010) (471 aa), Fasta scores: E(): 0, 99.8% identity in 471 aa overlap. Also highly similar to Mycobacterium tuberculosis proteins encoded downstream of several polyketide synthases e.g. Rv1182 TR:O50438 (EMBL:AL010186) (472 aa), Fasta scores: E(): 0, 75.8% identity in 471 aa overlap. Q49618 No lipid metabolism PF00668 Q49618 Rv1182 Rv1182 AL450380.2 Mycobrowser_v4 CDS 1536153 1537556 . + 0 ML1288 ML1288 possible peptidase ML1288, len: 467 aa. Possible peptidase. Similar to several members of the ARGE/DAPE/ACY1 protein family including: Mycobacterium tuberculosis Rv2141c, TR:O06234 (EMBL:Z95388) (448 aa), Fasta scores: E(): 0, 83.9% identity in 448 aa overlap and Streptomyces coelicolor putative aminoacylase TR:Q9ZBI7 (EMBL:AL035161) (443 aa), Fasta scores: E(): 0, 47.6% identity in 433 aa overlap). Contains Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40. Contains PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. Q9CC46 No intermediary metabolism and respiration PF01546,PF07687 Q9CC46 GO:0046983,GO:0006508,GO:0008270,GO:0008237 Rv2141c Rv2141c AL450380.2 Mycobrowser_v4 CDS 1233352 1234566 . + 0 ML1069 glgC PROBABLE GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE GLGC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase) ML1069, len: 404 aa. Probable glgC, glucose-1-phosphate adenylyltransferase (EC 2.7.7.27). Identical to the previously sequenced Mycobacterium leprae GlgC TR:Q49961 (EMBL:U15180) (419 aa), Fasta scores: E(): 0, 100.0% identity in 404 aa overlap. Also highly similar to many glucose-1-phosphate adenylyltransferases involved in glycogen biosynthesis e.g. from Mycobacterium tuberculosis Rv1213 SW:GLGC_MYCTU (O05314) (404 aa), Fasta scores: E(): 0, 92.6% identity in 404 aa overlap and Escherichia coli SW:GLGC_ECOLI (P00584) (430 aa), Fasta scores: E(): 0, 39.6% identity in 407 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Contains PS00809 ADP-glucose pyrophosphorylase signature 2. Contains PS00810 ADP-glucose pyrophosphorylase signature 3. Contains PS00808 ADP-glucose pyrophosphorylase signature 1. BELONGS TO THE BACTERIAL AND PLANTS GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE FAMILY. Q9CCA8 No intermediary metabolism and respiration PF00483 Q9CCA8 GO:0008878,GO:0005978,GO:0005524 2.7.7.27 Rv1213 Rv1213 AL450380.2 Mycobrowser_v4 CDS 1489173 1490843 . + 0 ML1248 ML1248 PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER ML1248, len: 556 aa. Probable ATP binding protein ABC-transporter. Highly similar to many proposed ABC-transporter ATP-binding proteins including: Escherichia coli SW: YJJK_ECOLI and Mycobacterium tuberculosis Rv2477c TR:O53204 (EMBL:AL021246) (558 aa), Fasta scores: E(): 0, 92.3% identity in 557 aa overlap. Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Contains 2 x PS00211 ABC transporters family signature. Q7AQ80 No cell wall and cell processes PF00005 Q7AQ80 GO:0016887,GO:0005524 Rv2477c Rv2477c AL450380.2 Mycobrowser_v4 CDS 1504776 1505408 . + 0 ML1259 hisB Probable imidazole glycerol-phosphate dehydratase HisB ML1259, len: 210 aa. Probable hisB, imidazole glycerol-phosphate dehydratase (EC 4.2.1.19). Highly similar to many imidazoleglycerol-phosphate dehydratases involved in histidine biosynthesis e.g. from Mycobacterium tuberculosis Rv1601 SW:HIS7_MYCTU (O06590) (210 aa), Fasta scores: E(): 0, 84.8% identity in 210 aa overlap and Streptomyces coelicolor SW:HIS7_STRCO (P16247) (197 aa), Fasta scores: E(): 0, 56.4% identity in 202 aa overlap. Contains 2 Pfam matches to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase. Contains PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. Contains PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. Belongs to the imidazoleglycerol-phosphate dehydratase family. Q9X7B9 No intermediary metabolism and respiration PF00475 Q9X7B9 GO:0000105,GO:0004424,GO:0005737 4.2.1.19 Rv1601 Rv1601 AL450380.2 Mycobrowser_v4 CDS 1513728 1514525 . + 0 ML1270 ML1270 possible conserved membrane protein ML1270, len: 265 aa. Possible conserved membrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1610 TR:O06128 (EMBL:Z95554) (235 aa), Fasta scores: E(): 0, 65.8% identity in 231 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. Q9CC55 No cell wall and cell processes PF09534 Q9CC55 Rv1610 Rv1610 AL450380.2 Mycobrowser_v4 CDS 1740908 1741462 . + 0 ML1448 sigC PROBABLE RNA POLYMERASE SIGMA FACTOR, ECF SUBFAMILY, SIGC ML1448, len: 184 aa. Probable sigC, RNA polymerase sigma factor, ECF subfamily. Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa), Fasta scores: E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis Rv2069 SW:RPSC_MYCTU (Q10679) (185 aa), Fasta scores: E(): 0, 81.2% identity in 181 aa overlap. Also similar to ML1956c a possible pseudogene similar to M. tuberculosis sigC. Contains a putative helix-turn-helix motif situated between residues 156..177 (+2.77 SD). Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature. Belongs to ECF subfamily. Q9CC01 No information pathways PF04542,PF08281 Q9CC01 GO:0016987,GO:0003700,GO:0006352,GO:0006355 Rv2069 Rv2069 AL450380.2 Mycobrowser_v4 CDS 1531870 1532487 . + 0 ML1286 ML1286 Probable two-component system transcriptional regulator ML1286, len: 205 aa. Probable two-component system transcriptional regulator. Similar to many proposed two-component response regulators including: Streptomyces coelicolor TR:Q9S2J0 (EMBL:AL109732) (218 aa), Fasta scores: E(): 0, 65.3% identity in 202 aa overlap and Azotobacter vinelandii TR:Q44531 (EMBL:X83602) (192 aa), Fasta scores: E(): 4.5e-11, 30.1% identity in 186 aa overlap. Also highly similar to Mycobacterium tuberculosis probable two-component response system transcriptional regulator Rv1626 TR:O06143 (EMBL:Z95554) (205 aa), Fasta scores: E(): 0, 90.7% identity in 205 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain. Q9CC47 No regulatory proteins PF00072,PF03861 Q9CC47 GO:0000156,GO:0000160,GO:0006355 Rv1626 Rv1626 AL450380.2 Mycobrowser_v4 CDS 1189188 1190912 . - 0 ML1022c sigA RNA polymerase sigma factor SigA ML1022c, len: 574 aa. Probable sigA (also known as rpoT), RNA polymerase sigma factor. Identical to the previously sequenced Mycobacterium leprae RNA polymerase sigma factor, rpoT TR:Q59532 (EMBL:U15181) (574 aa), Fasta scores: E(): 0, 99.8% identity in 574 aa overlap. Also highly similar to many other proposed sigma factors e.g. Mycobacterium tuberculosis SigA (RpoD), RNA polymerase sigma factor Rv2703 SW:RPSA_MYCTU (Q60162) (528 aa), Fasta scores: E(): 0, 80.5% identity in 533 aa overlap. The C-terminus is highly similar to ML1014 from M. leprae. Contains a probable helix-turn-helix motif at aa 533-554 (Score 1603, SD +4.65) Contains Pfam match to entry PF00140 sigma70, Sigma-70 factor. Contains PS00716 Sigma-70 factors family signature 2. Contains PS00715 Sigma-70 factors family signature 1. Belongs to the sigma-70 factor family. Previously known as rpoT. Q59532 No information pathways PF00140,PF04539,PF04542,PF04545 Q59532 GO:0016987,GO:0003700,GO:0006352,GO:0006355 Rv2703 Rv2703 AL450380.2 Mycobrowser_v4 CDS 1260031 1263813 . - 0 ML1095c sucA THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF 2-OXOGLUTARATE TO SUCCINYL-CoA & CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS:2-OXOGLUTARATE DEHYDROGENASE (E1), DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3) [CATALYTIC ACTIVITY: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2] PROBABLE 2-OXOGLUTARATE DEHYDROGENASE SUCA (Alpha-ketoglutarate dehydrogenase) ML1095c, len: 1260 aa. Probable sucA, 2-oxoglutarate dehydrogenase (EC 1.2.4.2). This CDS appears to constitute the E1 components of the 2-oxoglutarate dehydrogenase complex. The predicted product of this CDS is similar to several 2-oxoglutarate dehydrogenase e.g. Mycobacterium tuberculosis Rv1248c TR:O50463 (EMBL:AL021006) (1214 aa), Fasta scores: E(): 0, 89.0% identity in 1224 aa overlap and Corynebacterium glutamicum TR:P96746 (EMBL:D84102) (1257 aa), Fasta scores: E(): 0, 58.9% identity in 1253 aa overlap. Contains Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain). Contains Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component. Previously known as odhA. Q9CC97 No intermediary metabolism and respiration PF00198,PF00676,PF02779 Q9CC97 GO:0008415,GO:0006096,GO:0000287,GO:0004591,GO:0030976,GO:0006099,GO:0008683 4.1.1.71 Rv1248c Rv1248c AL450380.2 Mycobrowser_v4 CDS 1405884 1406276 . + 0 ML1192 acpS BIOSYNTHESIS OF FATTY ACIDS AND LIPIDS. TRANSFERS THE 4'-PHOSPHOPANTETHEINE MOIETY FROM COENZYME A TO A SER OF ACYL-CARRIER PROTEIN. CATALYZES THE FORMATION OF HOLO-ACP, WHICH MEDIATES THE TRANSFER OF ACYL FATTY-ACID INTERMEDIATES DURING THE BIOSYNTHESIS OF FATTY ACIDS AND LIPIDS [CATALYTIC ACTIVITY: CoA + APO-[ACYL-CARRIER PROTEIN] = ADENOSINE 3',5'-BISPHOSPHATE + HOLO-[ACYL-CARRIER PROTEIN] ]. HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIER PROTEIN]PANTETHEINEPHOSPHOTRANSFERASE) ML1192, len: 130 aa. Probable acpS, holo-[acyl-carrier protein] synthase (EC 2.7.8.7). Identical to the previously sequenced Mycobacterium leprae holo-[acyl-carrier protein] synthase (ACP) SW:ACPS_MYCLE (Q9X7E3) (130 aa), Fasta scores: E(): 0, 99.2% identity in 130 aa overlap. Also highly similar to ACPs from Mycobacterium tuberculosis Rv2523c SW:ACPS_MYCTU (O53228) (130 aa), Fasta scores: E(): 0, 86.7% identity in 128 aa overlap and Escherichia coli SW:ACPS_ECOLI (P24224) (125 aa), Fasta scores: E(): 0.00025, 35.1% identity in 131 aa overlap. Contains Pfam match to entry PF01648 ACPS, 4'-phosphopantetheinyl transferase superfamily. Q9X7E3 No lipid metabolism PF01648 Q9X7E3 GO:0006633,GO:0008897,GO:0009059,GO:0000287,GO:0005737 2.7.8.7 Rv2523c Rv2523c AL450380.2 Mycobrowser_v4 CDS 1279265 1279954 . + 0 ML1105 udgB conserved hypothetical protein ML1105, len: 229 aa. Conserved hypothetical protein. Similar to many proteins of undefined function including: Mycobacterium tuberculosis Rv1259 SW:YC59_MYCTU (Q11059) (299 aa), Fasta scores: E(): 0, 85.5% identity in 228 aa overlap and Streptomyces coelicolor TR:Q9S2L3 (EMBL:AL109732) (237 aa), Fasta scores: E(): 0, 54.5% identity in 231 aa overlap. Q9CC91 No conserved hypotheticals, information pathways PF03167 Q9CC91 Rv1259 Rv1259 AL450380.2 Mycobrowser_v4 CDS 1199240 1200529 . - 0 ML1036c arsA PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSA ML1036c, len: 429 aa. Probable arsA, arsenic-transport integral membrane protein. Identical to the previously sequenced Mycobacterium leprae probable membrane transport protein SW:AG45_MYCLE (P46838) (429 aa), Fasta scores: E(): 0, 99.8% identity in 429 aa overlap. Also highly similar to Mycobacterium tuberculosis arsenic-transport integral membrane proteins Rv2684 YQ84_MYCTU (O07186) (429 aa), Fasta scores: E(): 0, 74.3% identity in 428 aa overlap and O07187|YQ85_MYCTU|Rv2685 (428 aa), fasta scores: E(): 3.3e-128, (74.239% identity in 427 aa overlap). Contains multiple possible membrane spanning hydrophobic domains. P46838 No cell wall and cell processes PF03600 P46838 GO:0015137,GO:0015746,GO:0016021,GO:0005886,GO:0015105 Rv2684 Rv2684 AL450380.2 Mycobrowser_v4 CDS 2201528 2201920 . - 0 ML1818c trxB PROBABLE THIOREDOXIN TRXB ML1818c, len: 130 aa. Probable trxB, thioredoxin. Similar to M. tuberculosis thioredoxin trxB1 Rv1471 TR:O53162 (EMBL:AL021184) (123 aa), Fasta scores: E(): 2.4e-25, 65.4% identity in 107 aa overlap, and M. tuberculosis thioredoxin trxA Rv1470 TR:O53161 (EMBL:AL021184) (124 aa), Fasta scores: E(): 1.6e-17, 47.0% identity in 117 aa overlap. Also similar to Escherichia coli thioredoxin 2 SW:THI2_ECOLI (P33636) (139 aa), Fasta scores: E(): 1.7e-07, 37.1% identity in 89 aa overlap. Also similar to ML2703 from M. leprae. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Q9CBL1 No intermediary metabolism and respiration PF00085 Q9CBL1 GO:0045454 Rv1471 Rv1471 AL450380.2 Mycobrowser_v4 CDS 1333461 1335137 . + 0 ML1143 atpA PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA ML1143, len: 558 aa. Probable atpA, ATP synthase [alpha] chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase alpha chain (EC 3.6.1.34) SW:ATPA_MYCLE (P45825) (558 aa), Fasta scores: E(): 0, 100.0% identity in 558 aa overlap. Also highly similar to many other proposed ATPase alpha chain family proteins e.g. Mycobacterium tuberculosis Rv1308 TR:ATPA_MYCTU and Streptomyces lividans SW:ATPA_STRLI (P50001) (528 aa), Fasta scores: E(): 0, 69.0% identity in 516 aa overlap. Contains Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family. Contains Pfam match to entry PF00422 ATP-synt_A-c, ATP synthase Alpha chain, C terminal. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00152 ATP synthase alpha and beta subunits signature. P45825 No intermediary metabolism and respiration PF00006,PF00306,PF02874 P45825 GO:0046933,GO:0005886,GO:0042777,GO:0045261,GO:0046961,GO:0005524 3.6.3.14 Rv1308 Rv1308 AL450380.2 Mycobrowser_v4 CDS 1032059 1033114 . - 0 ML0868c cobT Involved in Cobalamin biosynthesis. Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). [Catalytic activity : Beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole. Probablenicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT ML0868c, len: 351 aa. Probable cobT, nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase (EC 2.4.2.21). Similar to Mycobacterium tuberculosis putative nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT or Rv2207 or MTCY190.18 SW:COBT_MYCTU (Q10396) (361 aa) fasta scores: E(): 0, 81.4% identity in 355 aa. Similar to many e.g. Salmonella typhimurium nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT SW:COBT_SALTY (Q05603) (356 aa) fasta scores: E(): 5.9e-32, 34.1% identity in 340 aa. Previously sequenced as O32953 (EMBL:Z98741). Belongs to the cobT family. O32953 No intermediary metabolism and respiration PF02277 O32953 GO:0015420,GO:0008939,GO:0009163,GO:0009236 2.4.2.21 Rv2207 Rv2207 AL450380.2 Mycobrowser_v4 CDS 1164320 1165210 . + 0 ML0996 dapF PROBABLE DIAMINOPIMELATE EPIMERASE DAPF (DAP EPIMERASE) ML0996, len: 296 aa. Probable dapF, diaminopimelate epimerase (EC 5.1.1.7). Identical to the previously sequenced Mycobacterium leprae diaminopimelate epimerase (DAP epimerase) involved in the biosynthesis of lysine from aspartate semialdehyde SW:DAPF_MYCLE (P46814) (296 aa), Fasta scores: E(): 0, 100.0% identity in 296 aa overlap. Also highly similar to DAP epimerases from Mycobacterium tuberculosis Rv2726c SW:DAPF_MYCTU (O33231) (289 aa), Fasta scores: E(): 0, 76.0% identity in 292 aa overlap and Escherichia coli SW:DAPF_ECOLI (P08885) (274 aa), Fasta scores: E(): 4.2e-13, 32.3% identity in 294 aa overlap. Contains Pfam match to entry PF01678 DAP_epimerase, Diaminopimelate epimerase. Contains PS01326 Diaminopimelate epimerase signature. Belongs to the diaminopimelate epimerase family. P46814 No intermediary metabolism and respiration PF01678 P46814 GO:0008837,GO:0009089,GO:0005737 5.1.1.7 Rv2726c Rv2726c AL450380.2 Mycobrowser_v4 CDS 1201218 1203149 . + 0 ML1038 dxs INVOLVED IN THE DEOXYXYLULOSE-5-PHOSPHATE PATHWAY (DXP) OF ISOPRENOIDBIOSYNTHESIS (AT THE FIRST STEP), AND IN THE BIOSYNTHETIC PATHWAY TO THIAMINE AND PYRIDOXOL (AT THE FIRST STEP). CATALYZES THE ACYLOIN CONDENSATION REACTION BETWEEN ATOMS 2 AND 3 OF PYRUVATE AND GLYCERALDEHYDE 3-PHOSPHATE TO YIELD 1-DEOXY-D-XYLULOSE-5-PHOSPHATE (DXP). PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) ML1038, len: 643 aa. Probable dxs1, 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-). Identical to the previously sequenced Mycobacterium leprae probable 1-deoxyxylulose-5-phosphate synthase (DXP synthase) SW:DXS_MYCL (Q50000) (643 aa), Fasta scores: E(): 0, 100.0% identity in 643 aa overlap. Also highly similar to many members of the transketolase family including DXP synthases from Mycobacterium tuberculosis Rv2682c SW:DXS_MYCTU (O07184) (638 aa), Fasta scores: E(): 0, 86.4% identity in 632 aa overlap and Escherichia coli SW:DXS_ECOLI (P77488) (619 aa), Fasta scores: E(): 0, 39.2% identity in 625 aa overlap. Contains PS00801 Transketolase signature 1. Contains PS00802 Transketolase signature 2. Q50000 No intermediary metabolism and respiration PF02779,PF02780 Q50000 GO:0016114,GO:0009228,GO:0008661 2.2.1.7 Rv2682c Rv2682c AL450380.2 Mycobrowser_v4 CDS 1016252 1017526 . + 0 ML0855 pepR PROBABLE ZINC PROTEASE PEPR ML0855, len: 424 aa. Probable pepR, protease/peptidase (EC 3.4.99.-). Similar to Mycobacterium tuberculosis hypothetical zinc protease Rv2782c or MTV002.47C SW:YR82_MYCTU (O33324) (438 aa) fasta scores: E(): 0, 84.3% identity in 421 aa and to others, both bacterial and eukaryotic e.g. Homo sapiens mitochondrial processing peptidase beta subunit precursor pmpcB or mppB SW:MPPB_HUMAN (O75439) (489 aa) fasta scores: E(): 0, 30.6% identity in 434 aa. Previously sequenced as SW:YR82_MYCLE (O32965). Contains Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase family M16). Contains PS00143 Insulinase family, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M16, ALSO KNOWN AS THE INSULINASE FAMILY. COFACTOR: REQUIRES DIVALENT CATIONS FOR ACTIVITY. BINDS ZINC. O32965 No intermediary metabolism and respiration PF00675,PF05193 O32965 GO:0006508,GO:0008270,GO:0004222 3.4.24.- Rv2782c Rv2782c AL450380.2 Mycobrowser_v4 CDS 1024956 1026746 . + 0 ML0862 ephD Possible short-chain dehydrogenase EphD ML0862, len: 596 aa. Possible ephD, short-chain dehydrogenase. Similar to Mycobacterium tuberculosis probable oxidoreductase ephD or Rv2214c or MTCY190.25C SW:EPHD_MYCTU (Q10402) (592 aa) fasta scores: E(): 0, 80.4% identity in 596 aa. Similar to many putative oxidorecuctases e.g. Streptomyces coelicolor putative oxidoreductase SCD78.21C TR:Q9ZBX8 (EMBL:AL034355) (585 aa) fasta scores: E(): 0, 42.4% id in 582 aa. C-terminal half is similar to Pseudomonas paucimobilis C alpha-dehydrogenase ligD SW:LIGD_PSEPA (Q01198) (305 aa) fasta scores: E(): 1.1e-15, 26.8% id in 269 aa. Previously sequenced as TR:O32958 (EMBL:Z98741). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. O32958 No virulence, detoxification, adaptation PF00106,PF00561 O32958 GO:0008152,GO:0016491,GO:0005488 Rv2214c Rv2214c AL450380.2 Mycobrowser_v4 CDS 1053286 1055088 . - 0 ML0887c fadD15 Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) ML0887c, len: 600 aa. Probable fadD15, long-chain-fatty-acid-CoA ligase (EC 6.2.1.3). Similar to Mycobacterium tuberculosis putative long-chain-fatty-acid-CoA ligase, fadD15, TR:O53521 (EMBL:AL021957) (600 aa), Fasta scores: E(): 0, 80.3% identity in 600 aa overlap. The C-terminus of the predicted product of this CDS is identical to the previously sequenced Mycobacterium leprae putative long-chain- fatty-acid-CoA ligase TR:O69578 (EMBL:AL022602) (351 aa), Fasta scores: E(): 0, 100.0% identity in 351 aa overlap. Also similar to Haemophilus influenzae putative long-chain-fatty-acid-CoA ligase (EC 6.2.1.3) SW:LCFH_HAEIN (SW:P44446) (607 aa), Fasta scores: E(): 0, 30.3% identity in 587 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Q9CCE6 No lipid metabolism PF00501 Q9CCE6 GO:0008152,GO:0016874 Rv2187 Rv2187 AL450380.2 Mycobrowser_v4 CDS 1628893 1629699 . + 0 ML1368 scpA conserved hypothetical protein ML1368, len: 268 aa. Conserved hypothetical protein. Similar to many proteins of undefined function e.g. Bacillus subtilis SW:YPUG_BACSU (P35154) (251 aa), Fasta scores: E(): 2e-12, 26.0% identity in 242 aa overlap and Mycobacterium tuberculosis Rv1709 TR:O33208 (EMBL:Z98268) (278 aa), Fasta scores: E(): 0, 78.9% identity in 251 aa overlap. Q7AQ60 No conserved hypotheticals, cell wall and cell processes PF02616 Q7AQ60 GO:0051301,GO:0007059,GO:0005737,GO:0007049 Rv1709 Rv1709 AL450380.2 Mycobrowser_v4 CDS 1013842 1016163 . + 0 ML0854 gpsI INVOLVED IN mRNA DEGRADATION. HYDROLYSES SINGLE-STRANDED POLYRIBONUCLEOTIDES PROCESSIVELY IN THE 3' TO 5' DIRECTION. INVOLVED IN THE RNA DEGRADOSOME, A MULTI-ENZYME COMPLEX IMPORTANT IN RNA PROCESSING AND MESSENGER RNA DEGRADATION [CATALYTIC ACTIVITY: RNA(N+1) + PHOSPHATE = RNA(N) + A NUCLEOSIDE DIPHOSPHATE]. BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (POLYNUCLEOTIDE PHOSPHORYLASE) (PNPASE) ML0854, len: 773 aa. Probable gpsI, polyribonucleotide nucleotidyltransferase (EC 2.7.7.8; 2.7.6.-). Similar to Mycobacterium tuberculosis guanosine pentaphosphate synthetase / polyribonucleotide nucleotidyltransferase gpsI or Rv2783c or MTV002.48C TR:O33325 (EMBL:AL008967) (752 aa) fasta scores: E(): 0, 90.0% identity in 757 aa, to Streptomyces antibioticus guanosine pentaphosphate synthetase gpsI TR:Q53597 (EMBL:U19858) (740 aa) fasta scores: E(): 0, 67.2% identity in 751 aa and to Bacillus subtilis polyribonucleotide nucleotidyltransferase pnpA or comR SW:PNPA_BACSU (P50849) (704 aa) fasta scores: E(): 0, 45.0% identity in 723 aa. Previously sequenced as TR:O32966 (EMBL:Z98741). Contains Pfam match to entry PF00013 KH-domain, KH domain. Contains 2 Pfam matches to entry PF01138 RNase_PH, 3' exoribonuclease family. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain. Q9CCF8 No information pathways PF00013,PF00575,PF01138,PF03725,PF03726 Q9CCF8 GO:0003723,GO:0006396,GO:0005737,GO:0006402,GO:0004654,GO:0000175 2.7.7.8 Rv2783c Rv2783c AL450380.2 Mycobrowser_v4 CDS 1502300 1503649 . + 0 ML1257 hisD Involved in histidine biosynthesis pathway (last step). THIS PROTEIN IS CONSIDERED AS A BIFUNCTIONAL ENZYME, POSSESSING TWO ACTIVE SITES, ONE AN ALCOHOL DEHYDROGENASE AND THE OTHER AN ALDEHYDE DEHYDROGENASE [CATALYTIC ACTIVITY : L-HISTIDINOL + 2 NAD(+) + H(2)O = L-HISTIDINE + 2 NADH]. Probable histidinol dehydrogenase HisD (HDH) ML1257, len: 449 aa. Probable hisD, histidinol dehydrogenase (EC 1.1.1.23). Highly similar to many histidinol dehydrogenases constituting the first stage in the histidine biosynthetic pathway e.g. Mycobacterium tuberculosis Rv1599 SW:HISX_MYCTU (Z95586) (438 aa), Fasta scores: E(): 0, 84.8% identity in 442 aa overlap and Mycobacterium smegmatis SW:HISX_MYCSM (P28736) (445 aa), Fasta scores: E(): 0, 77.5% identity in 449 aa overlap. Contains Pfam match to entry PF00815 Histidinol_dh, Histidinol dehydrogenase. Contains PS00611 Histidinol dehydrogenase signature. Belongs to the histidinol dehydrogenase family. Q9CC57 No intermediary metabolism and respiration PF00815 Q9CC57 GO:0008270,GO:0000105,GO:0004399,GO:0055114,GO:0051287 1.1.1.23 Rv1599 Rv1599 AL450380.2 Mycobrowser_v4 CDS 1325822 1326907 . + 0 ML1134 prfA PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA (RF-1) ML1134, len: 361 aa. Probable prfA, peptide chain release factor 1. Identical to the previously sequenced Mycobacterium leprae peptide chain release factor 1 (RF-1), directing the termination of translation, SW:RF1_MYCLE (P45833) (357 aa), Fasta scores: E(): 0, 99.7% identity in 357 aa overlap. Also highly similar to many other Prokaryotic and Eukaryotic chain release factors e.g. from Mycobacterium tuberculosis Rv1299 SW:RF1_MYCTU (Q10605) (357 aa), Fasta scores: E(): 0, 89.4% identity in 360 aa overlap and Kluyveromyces lactis (Yeast) SW:RF1M_KLULA (P41767) (396 aa), Fasta scores: E(): 0, 39.9% identity in 368 aa overlap. Contains Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain. Also similar to M. leprae ML0667. Contains PS00745 Prokaryotic-type class I peptide chain release factors signature. P45833 No information pathways PF00472,PF03462 P45833 GO:0016149,GO:0006415,GO:0005737 Rv1299 Rv1299 AL450380.2 Mycobrowser_v4 CDS 1410788 1413967 . + 0 ML1195 ileS isoleucyl-tRNA synthetase IleS ML1195, len: 1059 aa. Probable ileS, isoleucyl-tRNA synthase (EC 6.1.1.5). Identical to the previously sequenced Mycobacterium leprae isoleucyl-tRNA synthetase SW:SYI_MYCLE (Q9X7E5) (1059 aa), Fasta scores: E(): 0, 100.0% identity in 1059 aa overlap. Also highly similar to many Prokaryotic and Eukaryotic tRNA synthases e.g. Mycobacterium tuberculosis Rv1536 SW:SYI_MYCTU (Q10765) (1041 aa), Fasta scores: E(): 0, 84.4% identity in 1059 aa overlap and Schizosaccharomyces pombe SW:SYIC_SCHPO (O13651) (1064 aa), Fasta scores: E(): 0, 39.5% identity in 1041 aa overlap. Also similar to ML1472 (valyl-tRNA synthase) from M. leprae. Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Q9X7E5 No information pathways PF00133,PF08264 Q9X7E5 GO:0005737,GO:0004822,GO:0006428,GO:0008270,GO:0005524 6.1.1.5 Rv1536 Rv1536 AL450380.2 Mycobrowser_v4 CDS 1428254 1429537 . + 0 ML1209 ilvA INVOLVED IN ISOLEUCINE BIOSYNTHESIS (FIRST STEP). CATALYZES THE FORMATION OF ALPHA-KETOBUTYRATE FROM THREONINE IN A TWO STEP REACTION. THE FIRST STEP IS A DEHYDRATION OF THREONINE, FOLLOWED BY REHYDRATION AND LIBERATION OF AMMONIA [CATALYTIC ACTIVITY : L-THREONINE + H(2)O = 2-OXOBUTANOATE + NH(3) + H(2)O]. Probable threonine dehydratase IlvA ML1209, len: 427 aa. Probable ilvA, threonine dehydratase (EC 4.2.1.16). Identical to the previously sequenced Mycobacterium leprae probable threonine deaminase TR:Q9X7F1 (EMBL:AL04947) (427 aa), Fasta scores: E(): 0, 100.0% identity in 427 aa overlap. Highly similar to many other threonine dehydratase including: Mycobacterium tuberculosis Rv1559 SW:THD1_MYCT and Corynebacterium glutamicum SW:THD1_CORGL (Q04513) (436 aa), Fasta scores: E(): 0, 60.7% identity in 415 aa overlap. Contains Pfam match to entry PF00585 Thr_dehydrat_C, C-terminal domain of Threonine dehydratase. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. Q9X7F1 No intermediary metabolism and respiration PF00291,PF00585 Q9X7F1 GO:0009097,GO:0030170,GO:0004794 4.3.1.19 Rv1559 Rv1559 AL450380.2 Mycobrowser_v4 CDS 1175024 1175731 . - 0 ML1003c lexA INVOLVED IN REGULATION OF NUCLEOTIDE EXCISION REPAIR AND SOS RESPONSE. REPRESSES A NUMBER OF GENES INVOLVED IN THE RESPONSE TO DNA DAMAGE (SOS RESPONSE), INCLUDING RECA AND LEXA. HAS BEEN SHOWN TO BIND TO THE 14 BP PALINDROMIC SEQUENCE 5'-CGAACNNNNGTTCG-3'. IN THE PRESENCE OF SINGLE-STRANDED DNA, RECA INTERACTS WITH LEXA CAUSING AN AUTOCATALYTIC CLEAVAGE WHICH DISRUPTS THE DNA-BINDING PART OF LEXA, LEADING TO DEREPRESSION OF THE SOS REGULON AND EVENTUALLY DNA REPAIR [CATALYTIC ACTIVITY: HYDROLYSIS OF ALA-|-GLY BOND IN REPRESSOR LEXA]. REPRESSOR LEXA ML1003c, len: 235 aa. Probable lexA, repressor (EC 3.4.21.88). Identical to the previously sequenced Mycobacterium leprae LexA protein TR:Q49848 (EMBL:U00019) (235 aa), Fasta scores: E(): 0, 100.0% identity in 235 aa overlap. Also highly similar to many other LexA proteins known to repress genes in response to DNA damage, as part of the SOS response e.g. from Mycobacterium tuberculosis Rv2720 TR:Q50765 (EMBL:X91407) (217 aa), Fasta scores: E(): 0, 89.4% identity in 218 aa overlap and Escherichia coli SW:LEXA_ECOLI (P03033) (202 aa), Fasta scores: E(): 2.3e-10, 33.5% identity in 215 aa overlap. Note codon 19 represents an alternative possible translational start site. Contains Pfam match to entry PF00717 Peptidase_S24, Peptidase family S24. Contains Pfam match to entry PF01726 LexA_DNA_bind, LexA DNA binding domain. Q49848 No regulatory proteins PF00717,PF01726 Q49848 GO:0006281,GO:0006260,GO:0009432,GO:0045892,GO:0006508,GO:0004252,GO:0006350,GO:0003677 3.4.21.88 Rv2720 Rv2720 AL450380.2 Mycobrowser_v4 CDS 1690893 1692107 . + 0 ML1409 argD Probable Acetylornithine aminotransferase ArgD ML1409, len: 404 aa. Probable argD, Acetylornithine aminotransferase (EC 2.6.1.11). Highly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa), Fasta scores: E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis Rv1655 SW:ARGD_MYCTU (P94990) (400 aa), Fasta scores: E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Q9CC12 No intermediary metabolism and respiration PF00202 Q9CC12 GO:0006526,GO:0005737,GO:0030170,GO:0003992 2.6.1.11 Rv1655 Rv1655 AL450380.2 Mycobrowser_v4 CDS 1005909 1008083 . + 0 ML0848 ML0848 POSSIBLE TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSORTER ML0848, len: 724 aa. Possible transmembrane ATP-binding protein ABC transporter. Similar to Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein Rv2326c or MTCY3G12.08 SW:YN26_MYCTU (P71886) (697 aa) fasta scores: E(): 0, 76.9% identity in 697 aa. Shares similar domains with many ABC-type transporters e.g. Streptomyces roseofulvus ATPase component of putative ABC transporter frnD TR:O68910 (EMBL:AF058302) (524 aa) fasta scores: E(): 8.4e-14, 31.5% identity in 495 aa and Synechococcus sp. nitrate transport ATP-binding protein NrtD nrtD SW:NRTD_SYNP7 (P38046) (274 aa) fasta scores: E(): 1.6e-12, 34.8% identity in 198 aa. Previously sequenced as TR:O32971 (EMBL:Z98741). Contains hydrophobic, possible membrane-spanning regions. Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Contains 2 x PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q9CCF9 No cell wall and cell processes PF00005 Q9CCF9 GO:0016887,GO:0005524 Rv2326c Rv2326c AL450380.2 Mycobrowser_v4 CDS 1163318 1164253 . + 0 ML0995 miaA CATALYZES THE FIRST STEP IN THE BIOSYNTHESIS OF 2-METHYLTHIO-N6-(DELTA(2)-ISOPENTENYL)-ADENOSINE (MS[2]I[6]A]) ADJACENT TO THE ANTICODON OF SEVERAL TRNA SPECIES [CATALYTIC ACTIVITY: ISOPENTENYL DIPHOSPHATE + TRNA = PYROPHOSPHATE + TRNA CONTAINING 6-ISOPENTENYLADENOSINE]. PROBABLE TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE MIAA (IPP TRANSFERASE) (ISOPENTENYL-DIPHOSPHATE:TRNA ISOPENTENYLTRANSFERASE) (IPTASE) (IPPT) ML0995, len: 311 aa. Probable miaA, tRNA delta(2)-isopentenylpyrophosphate transferase (EC 2.5.1.8) . Identical to the previously sequenced Mycobacterium leprae tRNA delta(2)-isopentenylpyrophosphate transferase (EC 2.5.1.8) SW:MIAA_MYCLE (P46811) (311 aa), Fasta scores: E(): 0, 100.0% identity in 311 aa overlap, as well as several other IPP transferases e.g. from Mycobacterium tuberculosis SW:MIAA_MYCTU (O33232) (314 aa), Fasta scores: E(): 0, 82.2% identity in 314 aa overlap and Escherichia coli SW:MIAA_ECOLI (P16384) (316 aa), Fasta scores: E(): 2.2e-27, 35.5% identity in 293 aa overlap. Contains Pfam match to entry PF01715 IPPT, IPP transferase. Belongs to the IPP transferase family. P46811 No intermediary metabolism and respiration PF01715 P46811 GO:0016779,GO:0004811,GO:0008033,GO:0005524 2.5.1.8 Rv2727c Rv2727c AL450380.2 Mycobrowser_v4 CDS 1155734 1157287 . + 0 ML0989 ML0989 CONSERVED HYPOTHETICAL ALANINE, ARGININE-RICH PROTEIN ML0989, len: 517 aa. Conserved hypothetical protein. Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YR33_MYCLE (Q49842) (516 aa), Fasta scores: E(): 0, 99.8% identity in 516 aa overlap. Also highly similar to many other proteins of undefined function belonging to the the Pfam UPF0004 family, including: Mycobacterium tuberculosis Rv2733c SW:YR33_MYCTU (O33238) (512 aa), Fasta scores: E(): 0, 80.4% identity in 509 aa overlap and Bacillus subtilis YMCB_BACSU. Contains Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004. Contains PS01278 Uncharacterized protein family UPF0004 signature. Belongs to the UPF0004 family. Q49842 No conserved hypotheticals PF00919,PF04055 Q49842 GO:0005737,GO:0005506,GO:0006400,GO:0016740,GO:0051539 2.-.-.- Rv2733c Rv2733c AL450380.2 Mycobrowser_v4 CDS 1266651 1270109 . - 0 ML1098c ML1098c conserved hypothetical protein ML1098c, len: 1152 aa. Conserved hypothetical protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1251c TR:O50466 (EMBL:AL021006) (1139 aa), Fasta scores: E(): 0, 75.5% identity in 1141 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CC95 No conserved hypotheticals Q9CC95 GO:0000166,GO:0017111 Rv1251c Rv1251c AL450380.2 Mycobrowser_v4 CDS 1762675 1764114 . - 0 ML1465c obg PROBABLE GTP1/OBG-FAMILY GTP-BINDING PROTEIN OBG ML1465c, len: 479 aa. Probable obg, nucleotide-binding protein. Highly similar to several proposed GTP-binding proteins including: Escherichia coli SW:YHBZ_ECOLI (P42641) (390 aa), Fasta scores: E(): 0, 41.6% identity in 353 aa overlap and Mycobacterium tuberculosis hypothetical protein Rv2440c SW:P71909. Contains Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBZ4 No intermediary metabolism and respiration PF01018,PF01926,PF09269 Q9CBZ4 GO:0005622,GO:0005525 Rv2440c Rv2440c AL450380.2 Mycobrowser_v4 CDS 1287740 1289629 . - 0 ML1113c ML1113c PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER ML1113c, len: 629 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter. Highly similar to many proposed ABC transporter proteins including: Mycobacterium tuberculosis Rv1272c YC72_MYCTU (Q11047) (631 aa), Fasta scores: E(): 0, 75.4% identity in 623 aa overlap and Bacillus subtilis hypothetical ABC transporter ATP-binding protein SW:YFIC_BACSU (P54719) (604 aa), Fasta scores: E(): 0, 43.2% identity in 532 aa overlap. Also similar to the adjoining CDS ML1114. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Q9CC89 No cell wall and cell processes PF00005,PF00664 Q9CC89 GO:0042626,GO:0016021,GO:0006810,GO:0005524 Rv1272c Rv1272c AL450380.2 Mycobrowser_v4 CDS 1462236 1465187 . + 0 ML1231 mmpL10 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL10 ML1231, len: 983 aa. Probable mmpL10, conserved transmembrane transport protein. Previously sequenced Mycobacterium leprae membrane protein MMPL10 SW:MMLA_MYCLE (Q49619) (1008 aa), Fasta scores: E(): 0, 100.0% identity in 983 aa overlap. Also highly similar to many MMPL-family Mycobacterium tuberculosis proteins e.g. Rv1183 SW:MMLA_MYCTU (O50439) (1002 aa), Fasta scores: E(): 0, 70.4% identity in 978 aa overlap. Also similar to ML2378 and ML0137 from M. leprae. Contains possible membrane spanning hydrophobic domains. Q49619 No cell wall and cell processes PF03176 Q49619 GO:0005886,GO:0016021 Rv1183 Rv1183 AL450380.2 Mycobrowser_v4 CDS 1243758 1244909 . - 0 ML1080c mrp PROBABLE MRP-RELATED PROTEIN MRP ML1080c, len: 383 aa. Probable Mrp protein. Previously sequenced Mycobacterium leprae SW:MRP_MYCLE (P53382) (435 aa), Fasta scores: E(): 0, 100.0% identity in 383 aa overlap. Similar to many other MRP-family proteins, the function of which is unknown, e.g. Mycobacterium tuberculosis Rv1229c SW:MRP_MYCTU (O33225) (390 aa), Fasta scores: E(): 0, 82.1% identity in 374 aa overlap and Escherichia coli SW:MRP_ECOLI (P21590) (379 aa), Fasta scores: E(): 8.3e-30, 33.3% identity in 360 aa overlap. Contains Pfam match to entry PF01883 DUF59, Domain of unknown function. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS01215 Mrp family signature. BELONGS TO THE MRP/NBP35 FAMILY OF ATP-BINDING PROTEINS. P53382 No intermediary metabolism and respiration PF01883,PF10609 P53382 GO:0005524 Rv1229c Rv1229c AL450380.2 Mycobrowser_v4 CDS 2758991 2759683 . + 0 ML2327 cobQ2 POSSIBLE COBYRIC ACID SYNTHASE COBQ2 ML2327, len: 230 aa. Possible cobQ2, cobyric acid synthase. Similar to Mycobacterium tuberculosis cobQ2, cobyric acid synthase Rv3713 TR:O69680 (EMBL:AL022121) (231 aa) fasta scores: E(): 0, 86.5% identity in 230 aa. Also weakly similar to others e.g. Pseudomonas denitrificans cobB SW:COBB_PSEDE (P21632) (433 aa) fasta scores: E(): 0.0027, 30.7% identity in 166 aa. Contains Pfam match to entry PF01656 CBIA, Cobyrinic acid a,c-diamide synthase. Q7APW5 No intermediary metabolism and respiration PF07685 Q7APW5 GO:0009236,GO:0006541,GO:0003824 Rv3713 Rv3713 AL450380.2 Mycobrowser_v4 CDS 1339583 1340839 . + 0 ML1150 murA PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA ML1150, len: 418 aa. Probable murA, UDP-N-acetylglucosamine-1-carboxyvinyltransferase (EC 2.5.1.7). Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) SW:MURA_MYCLE (P45821) (418 aa), Fasta scores: E(): 0, 99.8% identity in 418 aa overlap representing the first step in peptidoglycan biosynthesis. Also highly similar to many other UDP-N-acetylglucosamine 1-carboxyvinyltransferases e.g. Mycobacterium tuberculosis Rv1315 SW:MURA_MYCTU (Q10604) (418 aa), Fasta scores: E(): 0, 95.9% identity in 417 aa overlap and Escherichia coli SW:MURA_ECOLI (P2890) (419 aa), Fasta scores: E(): 0, 45.7% identity in 416 aa overlap. Contains Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). P45821 No cell wall and cell processes PF00275 P45821 GO:0008760,GO:0007049,GO:0051301,GO:0007047,GO:0005737,GO:0009252,GO:0008360,GO:0019277 2.5.1.7 Rv1315 Rv1315 AL450380.2 Mycobrowser_v4 CDS 1062991 1064193 . - 0 ML0897c pknL PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L) ML0897c, len: 400 aa. Probable pknL, transmembrane serine/threonine-protein kinase (EC 2.7.1.-). Identical to the previously sequenced Mycobacterium leprae putative serine/threonine protein kinase TR:O69568 (EMBL:AL022602) (400 aa), Fasta scores: E(): 0, 99.8% identity in 400 aa overlap. Also highly similar to many other putative serine/threonine protein kinases e.g. from Mycobacterium tuberculosis: Rv2176 TR:O53510 (EMBL:AL021957) (399 aa), Fasta scores: E(): 0, 75.3% identity in 400 aa overlap and SW:PKNB_MYCTU (SW:P71584) (626 aa), Fasta scores: E(): 2e-31, 39.5% identity in 311 aa overlap. Also similar to ML0016 and ML0017 from M. leprae. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains PS00107 Protein kinases ATP-binding region signature. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES Q7AQD3 No regulatory proteins PF00069 Q7AQD3 GO:0006468,GO:0004674,GO:0005524 Rv2176 Rv2176 AL450380.2 Mycobrowser_v4 CDS 1184333 1185292 . - 0 ML1014c sigB THE SIGMA FACTOR IS AN INITIATION FACTOR THAT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC INITIATION SITES AND THEN IS RELEASED. MAY CONTROL THE REGULONS OF STATIONARY PHASE AND GENERAL STRESS RESISTANCE. IN M. TUBERCULOSIS IT SEEMS TO BE REGULATED BY SIGH AND SIGE. SEEMS TO REGULATE KATG AND THE HEAT-SHOCK RESPONSE RNA polymerase principal sigma factor SigB ML1014c, len: 319 aa. Probable sigB, RNA polymerase sigma factorIdentical to the previously sequenced Mycobacterium leprae RNA polymerase sigma factor TR:Q59531 (EMBL:U15181) (319 aa), Fasta scores: E(): 0, 100.0% identity in 319 aa overlap. Also highly similar to many Sigma-70 family proteins e.g. Mycobacterium tuberculosis Rv2710 TR:Q59563 (EMBL:U10059) (323 aa), Fasta scores: E(): 0, 96.2% identity in 316 aa overlap and Streptomyces coelicolor SW:HRDB_STRCO (P18183) (442 aa), Fasta scores: E(): 0, 60.7% identity in 303 aa overlap. Highly similar to the C-terminus of ML1022 from M. leprae. Contains a putative helix-turn-helix motif situated between residues 278..299 (+5.61 SD). Contains a probable helix-turn-helix motif at aa 278-299 (Score 1887, SD +5.61) Contains Pfam match to entry PF00140 sigma70, Sigma-70 factor. Contains PS00716 Sigma-70 factors family signature 2. Contains PS00715 Sigma-70 factors family signature 1. BELONGS TO THE SIGMA-70 FACTOR FAMILY. Q59531 No information pathways PF00140,PF04539,PF04542,PF04545 Q59531 GO:0016987,GO:0003700,GO:0006352,GO:0006355 Rv2710 Rv2710 AL450380.2 Mycobrowser_v4 CDS 2046991 2047824 . - 0 ML1698c ML1698c conserved membrane protein ML1698c, len: 277 aa. Conserved membrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv3005c TR:O53252 (EMBL:AL021287) (279 aa), Fasta scores: E(): 0, 68.7% identity in 278 aa overlap. Contains possible membrane spanning hydrophobic domains. Q7AQ27 No cell wall and cell processes, conserved hypotheticals PF07681 Q7AQ27 Rv3005c Rv3005c AL450380.2 Mycobrowser_v4 CDS 1319645 1320970 . + 0 ML1129 thrA INVOLVED IN THE CONVERSION OF L-ASPARTATE TO HOMOSERINE (THIRD STEP). HOMOSERINE PARTICIPATES IN THE BIOSYNTHESIS OF THREONINE AND THEN ISOLEUCINE AND IN THE BIOSYNTHESIS OF METHIONINE [CATALYTIC ACTIVITY : L-HOMOSERINE + NAD(P)(+) = L-ASPARTATE 4-SEMIALDEHYDE + NAD(P)H.] PROBABLE HOMOSERINE DEHYDROGENASE THRA ML1129, len: 441 aa. Probable thrA (hom), homoserine dehydrogenase (EC 1.1.1.3). Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase SW:DHOM_MYCLE (P46806) (441 aa), Fasta scores: E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa), Fasta scores: E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa), Fasta scores: E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS01042 Homoserine dehydrogenase signature. P46806 No intermediary metabolism and respiration PF00742,PF01842,PF03447 P46806 GO:0016597,GO:0004412,GO:0009097,GO:0009086,GO:0055114,GO:0009088,GO:0050661 1.1.1.3 Rv1294 Rv1294 AL450380.2 Mycobrowser_v4 CDS 1512142 1513731 . + 0 ML1269 trpE Possibly involved in biosynthesis of tryptophan (at the first step). Supposed tetramer of two components I and two components II: component I (ML1269|trpE) catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II (ML0015|trpG) provides glutamine aminotranferase activity. Possibly participates in the tryptophan-dependent indole-3-acetic acid production [Catalytic activity: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate]. Probable anthranilate synthase component I TrpE (GLUTAMINE AMIDOTRANSFERASE) ML1269, len: 529 aa. Probable trpE, anthranilate synthase component I (EC 4.1.3.27). Highly similar to many anthranilate synthase component I family proteins involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1609 SW:TRPE_MYCTU (O06127) (516 aa), Fasta scores: E(): 0, 88.0% identity in 508 aa overlap and Pseudomonas putida SW:TRPE_PSEPU (P20579) (493 aa), Fasta scores: E(): 0, 44.4% identity in 504 aa overlap. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. Q9X7C5 No intermediary metabolism and respiration PF00425,PF04715 Q9X7C5 GO:0000162,GO:0004049 4.1.3.27 Rv1609 Rv1609 AL450380.2 Mycobrowser_v4 CDS 1546120 1546968 . + 0 ML1297 ML1297 Possible conserved transmembrane protein ML1297, len: 282 aa. Possible conserved transmembrane protein. Similar to Mycobacterium tuberculosis Rv2136c TR:O06239 (EMBL:Z95388) (276 aa), Fasta scores: E(): 0, 82.6% identity in 276 aa overlap. Also similar to several proposed undecaprenol kinases or bacitracin resistance proteins including: Escherichia coli SW:BACA_ECOLI (P31054) (273 aa), Fasta scores: E(): 3.7e-23, 34.0% identity in 265 aa overlap and Contains multiple possible membrane spanning hydrophobic domains. Q9CC42 No cell wall and cell processes PF02673 Q9CC42 GO:0016311,GO:0016021,GO:0009252,GO:0005886,GO:0008360,GO:0046677,GO:0050380,GO:0007047 3.6.1.27 Rv2136c Rv2136c AL450380.2 Mycobrowser_v4 CDS 1543268 1544341 . - 0 ML1293c pyrD Probable dihydroorotate dehydrogenase PyrD ML1293c, len: 357 aa. Probable pyrD, dihydroorotate dehydrogenase (EC 1.3.3.1). Highly similar to many dihydroorotate dehydrogenases involved in pyrimidine biosynthesis, including: Escherichia coli PyrD SW:PYRD_ECOLI (P05021) (336 aa), Fasta scores: E(): 0, 42.3% identity in 333 aa overlap and Mycobacterium tuberculosis PyrD Rv2139 SW:PYRD_MYCTU (O06236) (357 aa), Fasta scores: E(): 0, 80.9% identity in 351 aa overlap. Contains Pfam match to entry PF01180 DHOdehase, Dihydroorotate dehydrogenase. Contains PS00912 Dihydroorotate dehydrogenase signature 2. Contains PS00911 Dihydroorotate dehydrogenase signature 1. P46727 No intermediary metabolism and respiration PF01180 P46727 GO:0006222,GO:0004158,GO:0055114,GO:0005886,GO:0006207 1.3.3.1 Rv2139 Rv2139 AL450380.2 Mycobrowser_v4 CDS 1552523 1554019 . - 0 ML1304c ansP1 POSSIBLE L-ASPARAGINE PERMEASE ANSP1 (L-ASPARAGINE TRANSPORT PROTEIN) ML1304c, len: 498 aa. Probable ansP1, L-asparagine permeas. Highly similar to many L-asparagine transport proteins including: Salmonella typhimurium AnsP SW:ANSP_SALTY (P40812) (497 aa), Fasta scores: E(): 0, 58.7% identity in 477 aa overlap and Mycobacterium tuberculosis Rv2127 SW:ANSP_MYCTU (O33261) (489 aa), Fasta scores: E(): 0, 83.4% identity in 488 aa overlap and O06297|Rv0346c Possible ansP2, L-asparagine permease (487 aa), fasta scores: E(): 5.5e-129, (69.556% identity in 473 aa overlap). Almost identical to the duplicated sequence ML1305. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains PS00218 Amino acid permeases signature. Q49801 No cell wall and cell processes PF00324 Q49801 GO:0006865,GO:0016021,GO:0015171 Rv0346c Rv0346c AL450380.2 Mycobrowser_v4 CDS 1759309 1761351 . - 0 ML1463c nadE PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) ML1463c, len: 680 aa. Probable nadE, glutamine-dependent NAD(+) synthetase (EC 6.3.5.1). Highly similar to several e.g. Rhodobacter capsulatus SW:NADE_RHOCA (Q03638) (552 aa), Fasta scores: E(): 3.6e-11, 24.9% identity in 579 aa overlap glutamine-dependent NAD(+) synthetase and Mycobacterium tuberculosis Rv2438c TR:P71911 (EMBL:Z81451) (679 aa), Fasta scores: E(): 0, 84.4% identity in 679 aa overlap. Contains Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase. Contains PS00591 Glycosyl hydrolases family 10 active site. BELONGS TO THE NAD SYNTHETASE FAMILY IN THE C-TERMINAL SECTION. Q9CBZ6 No intermediary metabolism and respiration PF00795,PF02540 Q9CBZ6 GO:0009435,GO:0003952,GO:0016810,GO:0006807,GO:0005524 6.3.5.1 Rv2438c Rv2438c AL450380.2 Mycobrowser_v4 CDS 1579805 1581163 . + 0 ML1328 paf Probable proteasome associated factor Paf ML1328, len: 452 aa. Probable paf, proteasome associated factor (see Darwin et al., 2003). Highly similar to Mycobacterium tuberculosis Rv2097c SW:YK97_MYCTU (Q10706) paf, proteasome associated factor (452 aa), Fasta scores: E(): 0, 94.9% identity in 452 aa overlap. And many proteins of unknown function including: Rhodococcus erythropolis TR:P72263 (EMBL:Z82004) (447 aa), Fasta scores: E(): 0, 89.3% identity in 447 aa overlap. Contains a putative helix-turn-helix motif situated between residues 380..401 (+3.12 SD). Contains a probable helix-turn-helix motif at aa 380-401 (Score 1155, SD +3.12). P54077 No cell wall and cell processes, intermediary metabolism and respiration PF03136,PF03316 P54077 Rv2097c Rv2097c AL450380.2 Mycobrowser_v4 CDS 1583188 1583475 . + 0 ML1331 tatA INVOLVED IN PROTEINS EXPORT: REQUIRED FOR CORRECT LOCALIZATION OF PRECURSOR PROTEINS BEARING SIGNAL PEPTIDES WITH THE TWIN ARGININE CONSERVED MOTIF S/T-R-R-X-F-L-K. THIS SEC-INDEPENDENT PATHWAY IS TERMED TAT FOR TWIN-ARGININE TRANSLOCATION SYSTEM. THIS SYSTEM MAINLY TRANSPORTS PROTEINS WITH BOUND COFACTORS THAT REQUIRE FOLDING PRIOR TO EXPORT. PROBABLE SEC-INDEPENDENT PROTEIN TRANSLOCASE MEMBRANE-BOUND PROTEIN TATA ML1331, len: 95 aa. Probable tatA, membrane-bound protein, component of twin-arginine translocation protein export system (see Berks et al., 2000). Highly similar to others e.g. Streptomyces coelicolor putative secreted protein TR:Q9RJ68 (EMBL:AL132648) (95 aa), Fasta scores: E(): 5.1e-09, 45.3% identity in 86 aa overlap and Mycobacterium tuberculosis Rv2094c SW:YK94_MYCTU (Q10703) (83 aa), Fasta scores: E(): 5.2e-21, 68.2% identity in 88 aa overlap. Contains a possible N-terminal signal sequence. Note codon 8 may offer an alternative translational start site. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE TATA/E FAMILY. P54079 No cell wall and cell processes PF02416 P54079 GO:0065002,GO:0005886,GO:0009306,GO:0008565,GO:0016021 Rv2094c Rv2094c AL450380.2 Mycobrowser_v4 CDS 1595453 1596775 . - 0 ML1338c ML1338c possible conserved integral membrane protein ML1338c, len: 440 aa. Possible conserved integral membrane protein. Similar to several membrane proteins e.g. Mycobacterium tuberculosis Rv2673 TR:P71970 (EMBL:Z80225) (433 aa), Fasta scores: E(): 0, 82.0% identity in 434 aa overlap and weakly similar to Streptomyces coelicolor TR:Q53873 (EMBL:AL031317) (411 aa), Fasta scores: E(): 1.1e-12, 28.3% identity in 410 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q7AQ64 No cell wall and cell processes PF09594 Q7AQ64 Rv2673 Rv2673 AL450380.2 Mycobrowser_v4 CDS 1611524 1612168 . + 0 ML1351 mpg POSSIBLE 3-METHYLADENINE DNA GLYCOSYLASE MPG ML1351, len: 214 aa. Possible mpg, 3-methylpurine DNA glycosylase (EC 3.2.2.-). Similar to several DNA-3-methyladenine glycosylases from both Prokaryotes and Eukaryotes e.g. Bacillus subtilis SW:3MGH_BACSU (P94378) (196 aa), Fasta scores: E(): 7.7e-13, 38.4% identity in 185 aa overlap and Arabidopsis thaliana SW:3MG_ARATH (Q39147) (254 aa), Fasta scores: E(): 1.1e-11, 32.0% identity in 194 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv1688 putative 3-methyladenine DNA glycosylase SW:3MGH_MYCTU (O33190) (203 aa), Fasta scores: E(): 0, 78.3% identity in 203 aa overlap. Note codon 12 may offer an alternative translational start site. O05678 No information pathways PF02245 O05678 GO:0003905,GO:0006284,GO:0003677 3.2.2.- Rv1688 Rv1688 AL450380.2 Mycobrowser_v4 CDS 1624156 1625928 . + 0 ML1363 pyrG Probable CTP synthase PyrG ML1363, len: 590 aa. Probable pyrG, CTP synthase (EC 6.3.4.2). Highly similar to many CTP synthases, catalysing the last step in pyrimidine biosynthesis, including: Escherichia coli SW:PYRG_ECOLI (P08398) (544 aa), Fasta scores: E(): 0, 50.5% identity in 548 aa overlap and Mycobacterium tuberculosis Rv1699 SW:PYRG_MYCTU (P96351) (586 aa), Fasta scores: E(): 0, 89.2% identity in 590 aa overlap. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. P53529 No intermediary metabolism and respiration PF00117,PF06418 P53529 GO:0003883,GO:0006541,GO:0006221,GO:0005524 6.3.4.2 Rv1699 Rv1699 AL450380.2 Mycobrowser_v4 CDS 1626542 1627492 . + 0 ML1365 ML1365 PROBABLE INTEGRASE/RECOMBINASE ML1365, len: 316 aa. Probable integrase/recombinase. Highly similar to several including: Escherichia coli integrase/recombinase XerD which is involved in site specific recombination, SW:XERD_ECOLI (P21891) (298 aa), Fasta scores: E(): 5.7e-29, 40.3% identity in 308 aa overlap. Also similar to several other Mycobacterium tuberculosis integrase/recombinases e.g. Rv1701 TR:O33200 (EMBL:Z98268) (311 aa), Fasta scores: E(): 0, 85.9% identity in 311 aa overlap and Rv2894c SW:YS94_MYCTU (Q10815) (298 aa), Fasta scores: E(): 0, 42.9% identity in 312 aa overlap. Also similar to ML1365 from M. leprae. Contains Pfam match to entry PF00589 Phage_integrase, 'Phage' integrase family. Q49890 No insertion seqs and phages PF00589,PF02899 Q49890 GO:0015074,GO:0007049,GO:0051301,GO:0007059,GO:0005737,GO:0006313,GO:0009037,GO:0003677 Rv1701 Rv1701 AL450380.2 Mycobrowser_v4 CDS 1652732 1654177 . + 0 ML1382 rpsA PROBABLE RIBOSOMAL PROTEIN S1 RPSA ML1382, len: 481 aa. Probable rpsA, 30S ribosomal protein S1. Highly similar to multiple 30S ribosomal proteins S1 including: Escherichia coli SW:RS1_ECOLI (P02349) (557 aa), Fasta scores: E(): 0, 39.1% identity in 471 aa overlap and Mycobacterium tuberculosis Rv1630 SW:RS1_MYCTU (O06147) (481 aa), Fasta scores: E(): 0, 93.8% identity in 481 aa overlap. Previously sequenced SW:RS1_MYCLE (P46836) (482 aa), Fasta scores: E(): 0, 93.2% identity in 483 aa overlap. Contains 4 Pfam matches to entry PF00575 S1, S1 RNA binding domain. P46836 No information pathways PF00575 P46836 GO:0005840,GO:0003735,GO:0006412,GO:0003723 Rv1630 Rv1630 AL450380.2 Mycobrowser_v4 CDS 1665178 1666761 . - 0 ML1389c ML1389c Probable conserved transmembrane protein ML1389c, len: 527 aa. Probable conserved transmembrane protein. Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1635c TR:O06152 (EMBL:Z95554) (556 aa), Fasta scores: E(): 0, 71.6% identity in 528 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Also similar to ML2515 a possible pseudogene similar to M. tuberculosis Rv1635c. Q9CC27 No cell wall and cell processes Q9CC27 Rv1635c Rv1635c AL450380.2 Mycobrowser_v4 CDS 1629747 1630442 . + 0 ML1369 scpB conserved hypothetical protein ML1369, len: 231 aa. Conserved hypothetical protein. Similar to many proteins of undefined function e.g. Streptomyces coelicolor TR:Q9S231 (EMBL:AL109848) (223 aa), Fasta scores: E(): 0, 54.5% identity in 187 aa overlap and Mycobacterium tuberculosis Rv1710 TR:O33209 (EMBL:Z98268) (231 aa), Fasta scores: E(): 0, 77.9% identity in 231 aa overlap. Q7AQ59 No conserved hypotheticals, cell wall and cell processes PF04079 Q7AQ59 GO:0051301,GO:0007059,GO:0005737,GO:0007049 Rv1710 Rv1710 AL450380.2 Mycobrowser_v4 CDS 1692181 1693101 . + 0 ML1410 argF Probable Ornithine carbamoyltransferase, anabolic ArgF ML1410, len: 306 aa. Probable argF, Ornithine carbamoyltransferase (EC 2.1.3.3). Highly similar to many ornithine carbamoyltransferase involved in arginine biosynthesis, including: Bacillus subtilis SW:OTCA_BACSU (P18186) (319 aa), Fasta scores: E(): 0, 48.0% identity in 304 aa overlap and Mycobacterium tuberculosis Rv1656 SW:OTCA_MYCTU (P94991) (307 aa), Fasta scores: E(): 0, 85.0% identity in 306 aa overlap. Start changed, was originally 15 codons upstream. Contains Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature. Q9CC11 No intermediary metabolism and respiration PF00185,PF02729 Q9CC11 GO:0006526,GO:0004585,GO:0009348,GO:0016597 2.1.3.3 Rv1656 Rv1656 AL450380.2 Mycobrowser_v4 CDS 1711570 1712640 . - 0 ML1424c ML1424c Probable sugar-transport ATP-binding protein ABC transporter ML1424c, len: 356 aa. Probable sugar-transport ATP-binding protein ABC transporter. Highly similar to several binding-protein-dependent transport proteins including: Escherichia coli SN-glycerol-3-phosphate transport ATP-binding protein SW:UGPC_ECOLI (P10907) (356 aa), Fasta scores: E(): 0, 47.9% identity in 363 aa overlap and Mycobacterium tuberculosis ABC-type sugar transport protein Rv2038c TR:O53482 (EMBL:AL021899) (357 aa), Fasta scores: E(): 0, 79.7% identity in 355 aa overlap. Also similar to ML1089, ML0669 and ML1892 from M. leprae. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Q7AQ54 No cell wall and cell processes PF00005,PF08402 Q7AQ54 GO:0043190,GO:0016887,GO:0008643,GO:0016820,GO:0005351,GO:0005524 Rv2038c Rv2038c AL450380.2 Mycobrowser_v4 CDS 1712643 1713494 . - 0 ML1425c ML1425c Probable sugar-transport integral membrane protein ABC transporter ML1425c, len: 283 aa. Probable sugar-transport integral membrane protein ABC transporter. Highly similar to many putative ABC_transport proteins e.g. Mycobacterium tuberculosis sugar transport protein Rv2039c TR:O53483 (EMBL:AL021899) (280 aa), Fasta scores: E(): 0, 79.2% identity in 283 aa overlap. Also similar to ML2039c from M. leprae. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Q7AQ53 No cell wall and cell processes PF00528 Q7AQ53 GO:0005886,GO:0006810,GO:0005215,GO:0016021 Rv2039c Rv2039c AL450380.2 Mycobrowser_v4 CDS 1714437 1715774 . - 0 ML1427c ML1427c Probable sugar-binding lipoprotein ML1427c, len: 445 aa. Probable sugar-binding lipoprotein. Similar to several putative ABC_transport proteins e.g. Mycobacterium tuberculosis lipoprotein component of sugar transport system Rv2041c TR:O53485 (EMBL:AL021899) (439 aa), Fasta scores: E(): 0, 77.4% identity in 446 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q7AQ51 No cell wall and cell processes PF01547 Q7AQ51 GO:0005215,GO:0006810 Rv2041c Rv2041c AL450380.2 Mycobrowser_v4 CDS 3063270 3063896 . - 0 ML2568c ML2568c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) ML2568c, len: 208 aa. Possible transcriptional regulatory protein (TetR-family). Similar to several putative transcriptional regulators e.g. Mycobacterium tuberculosis Rv0238 TR:O53661 (EMBL:AL021929) fasta scores: E(): 0, 80.9% id in 199 aa, and to Streptomyces coelicolor TR:CAB77290 (EMBL:AL160312) fasta scores: E(): 2.7e-20, 39.0% identity in 205 aa. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Q7APU1 No regulatory proteins PF00440 Q7APU1 GO:0003700,GO:0006355 Rv0238 Rv0238 AL450380.2 Mycobrowser_v4 CDS 1751755 1752984 . - 0 ML1458c proA INVOLVED IN PROLINE BIOSYNTHESIS PATHWAY (AT THE SECOND STEP). CATALYZES THE NADPH DEPENDENT REDUCTION OF L-GAMMA- GLUTAMYL 5-PHOSPHATE INTO L-GLUTAMATE 5-SEMIALDEHYDE AND PHOSPHATE. THE PRODUCT SPONTANEOUSLY UNDERGOES CYCLIZATION TO FORM 1-PYRROLINE-5-CARBOXYLATE. [CATALYTIC ACTIVITY: L-GLUTAMATE 5-SEMIALDEHYDE + PHOSPHATE + NADP(+) = L-GAMMA-GLUTAMYL 5-PHOSPHATE + NADPH]. PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDEHYDE DEHYDROGENASE) ML1458c, len: 409 aa. Probable proA, gamma-glutamyl phosphate reductase protein (EC 1.2.1.41). Highly similar to many gamma-glutamyl phosphate reductases involved in proline biosynthesis, e.g. Bacillus subtilis SW:PROA_BACSU (P39821) (415 aa), Fasta scores: E(): 0, 47.3% identity in 412 aa overlap and Mycobacterium tuberculosis Rv2427c SW:PROA_MYCTU (P71921) (415 aa), Fasta scores: E(): 0, 82.2% identity in 409 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS01223 Gamma-glutamyl phosphate reductase signature. BELONGS TO THE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE FAMILY. Q9CBZ7 No intermediary metabolism and respiration PF00171 Q9CBZ7 GO:0005737,GO:0004350,GO:0055114,GO:0006561,GO:0050661 1.2.1.41 Rv2427c Rv2427c AL450380.2 Mycobrowser_v4 CDS 1765045 1767819 . - 0 ML1468c rne possible ribonuclease E Rne ML1468c, len: 924 aa. Possible rne, ribonuclease (EC 3.1.-.-). Highly similar in parts to many ribonucleases e.g. Escherichia coli ribonuclease E SW:RNE_ECOLI (P21513) (1061 aa), Fasta scores: E(): 1.6e-22, 36.4% identity in 429 aa overlap and Mycobacterium tuberculosis Rv2444c TR:P71905 (EMBL:Z81451) (953 aa), Fasta scores: E(): 0, 74.2% identity in 966 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain. Q9CBZ1 No information pathways PF00575,PF10150 Q9CBZ1 GO:0006396,GO:0005737,GO:0004540,GO:0003723 Rv2444c Rv2444c AL450380.2 Mycobrowser_v4 CDS 1764229 1764495 . - 0 ML1466c rpmA PROBABLE 50S RIBOSOMAL PROTEIN L27 RPMA ML1466c, len: 88 aa. Probable rpmA, 50S ribosomal protein L27. Highly similar to many 50s ribosomal proteins (L27) including: Escherichia coli SW:RL27_ECOLI (P02427) (84 aa), Fasta scores: E(): 5.8e-16, 63.9% identity in 83 aa overlap and Mycobacterium tuberculosis Rv2441c SW:RL27_MYCTU (Z8145) (86 aa), Fasta scores: E(): 3.3e-28, 93.8% identity in 81 aa overlap. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein. Contains PS00831 Ribosomal protein L27 signature. Q9CBZ3 No information pathways PF01016 Q9CBZ3 GO:0003735,GO:0006412,GO:0005840 Rv2441c Rv2441c AL450380.2 Mycobrowser_v4 CDS 1768990 1770447 . - 0 ML1471c folC CONVERSION OF FOLATES TO POLYGLUTAMATE DERIVATIVES. BACTERIA REQUIRE FOLATE FOR THE BIOSYNTHESIS OF GLYCINE, METHIONINE, FORMYL-MET-TRNA, THYMIDYLATES, PURINES, AND PANTOTHENATE [CATALYTIC ACTIVITY: ATP + {TETRAHYDROFOLYL-[GLU]}(N) + L-GLUTAMATE = ADP + PHOSPHATE + {TETRAHYDROFOLYL-[GLU]}(N+1)]. PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) ML1471c, len: 485 aa. Probable folC, folylpolyglutamate synthase (EC 6.3.2.17). Highly similar to many folylpolyglutamate synthases including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa), Fasta scores: E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis Rv2447c TR:O53174 (EMBL:AL021246) (487 aa), Fasta scores: E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. BELONGS TO THE FOLYLPOLYGLUTAMATE SYNTHASE FAMILY. Q9CBY8 No intermediary metabolism and respiration PF02875,PF08245 Q9CBY8 GO:0009396,GO:0004326,GO:0005524 Rv2447c Rv2447c AL450380.2 Mycobrowser_v4 CDS 1787919 1788542 . - 0 ML1485c ML1485c conserved hypothetical protein ML1485c, len: 207 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2466c TR:O53193 (EMBL:AL02124) (207 aa), Fasta scores: E(): 0, 80.6% identity in 206 aa overlap and Streptomyces coelicolor TR:CAB71809 (EMBL:AL138662) (216 aa), Fasta scores: E(): 0, 52.3% identity in 214 aa overlap. Q9CBY0 No conserved hypotheticals Q9CBY0 Rv2466c Rv2466c AL450380.2 Mycobrowser_v4 CDS 1783575 1784984 . - 0 ML1481c tig PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG ML1481c, len: 469 aa. Probable tig, trigger factor (TF), a chaperone protein. Highly similar to many including: Escherichia coli trigger factor Tig, SW:TIG_ECOLI (P22257) (432 aa), Fasta scores: E(): 8.1e-23, 25.4% identity in 433 aa overlap and Mycobacterium tuberculosis trigger factor Rv2462c SW:TIG_MYCTU (O53189) (466 aa), Fasta scores: E(): 0, 70.1% identity in 468 aa overlap. Q9CBY2 No cell wall and cell processes PF00254,PF05697,PF05698 Q9CBY2 GO:0051301,GO:0003755,GO:0006457,GO:0015031,GO:0007049 Rv2462c Rv2462c AL450380.2 Mycobrowser_v4 CDS 1822935 1824611 . - 0 ML1512c ML1512c conserved hypothetical protein ML1512c, len: 558 aa. Conserved hypothetical protein. Highly similar to many proteins of undefined function including: Bacillus subtilis SW:YKQC_BACSU (Q45493) (555 aa), Fasta scores: E(): 0, 36.9% identity in 547 aa overlap and Mycobacterium tuberculosis Rv2752c TR:O33294 (EMBL:AL008967) (558 aa), Fasta scores: E(): 0, 89.1% identity in 558 aa overlap. Contains Pfam match to entry PF02147 UPF0036, Uncharacterized protein family UPF0036. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Q9CBW5 No conserved hypotheticals PF00753,PF07521 Q9CBW5 GO:0016787 Rv2752c Rv2752c AL450380.2 Mycobrowser_v4 CDS 1794103 1794429 . - 0 ML1489c fdxC PROBABLE FERREDOXIN FDXC ML1489c, len: 108 aa. Probable fdxC, ferredoxin. Highly similar to many ferredoxins including: Mycobacterium smegmatis SW:FER_MYCSM (P00215) (106 aa), Fasta scores: E(): 0, 86.7% identity in 105 aa overlap and Mycobacterium tuberculosis Rv1177 TR:O50433 (EMBL:AL010186) (108 aa), Fasta scores: E(): 0, 90.6% identity in 106 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S binding domain. Contains PS00198 4Fe-4S ferredoxins. Note previously known as fdxA. Q9CBX7 No intermediary metabolism and respiration PF00037 Q9CBX7 GO:0051536,GO:0009055 Rv1177 Rv1177 AL450380.2 Mycobrowser_v4 CDS 1550234 1551388 . + 0 ML1302 mshC Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC ML1302, len: 384 aa. Probable mshC, cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase (see Rawat et al., 2002). Highly similar to multiple cysteinyl-tRNA synthetases including: Escherichia coli SW:SYC_ECOLI (P21888) (461 aa), Fasta scores: E(): 0, 36.8% identity in 386 aa overlap and to Mycobacterium tuberculosis Rv2130C SW:SYC2_MYCTU (O33264) mshC, cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase (414 aa), Fasta scores: E(): 0, 85.1% identity in 383 aa overlap. Contains Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C). Note previously known as cysS2. Q49784 No intermediary metabolism and respiration PF01406 Q49784 GO:0004817,GO:0006423,GO:0005737,GO:0005524 6.1.1.16 Rv2130c Rv2130c AL450380.2 Mycobrowser_v4 CDS 1788674 1791262 . + 0 ML1486 pepN PROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE) ML1486, len: 862 aa. Probable pepN, aminopeptidase (EC 3.4.11.2). Highly similar to many aminopeptidases including: Streptomyces lividans aminopeptidase N (EC 3.4.11.2) SW:AMPN_STRLI (Q11010) (857 aa), Fasta scores: E(): 0, 51.6% identity in 866 aa overlap and Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa), Fasta scores: E(): 0, 83.3% identity in 862 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1, Peptidase family M1. Contains PS00142 Neutral zinc metallopeptidases. BELONGS TO PEPTIDASE FAMILY M1 (ZINC METALLOPROTEASE), ALSO KNOWN AS THE PEPN SUBFAMILY. Q9CBX9 No intermediary metabolism and respiration PF01433 Q9CBX9 GO:0008237,GO:0006508,GO:0008270,GO:0004177 Rv2467 Rv2467 AL450380.2 Mycobrowser_v4 CDS 1693617 1694816 . + 0 ML1412 argG Probable Argininosuccinate synthase ArgG (Citrulline--aspartate ligase) ML1412, len: 399 aa. Probable argG, Argininosuccinate synthase (EC 6.3.4.5). Highly similar to many argininosuccinate synthases involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa), Fasta scores: E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis Rv1658 SW:ASSY_MYCTU (P94993) (398 aa), Fasta scores: E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2. Belongs to the argininosuccinate synthase family. Subfamily 1 Q9CC10 No intermediary metabolism and respiration PF00764 Q9CC10 GO:0006526,GO:0004055,GO:0005737,GO:0005524 6.3.4.5 Rv1658 Rv1658 AL450380.2 Mycobrowser_v4 CDS 1905767 1906945 . - 0 ML1581c gcpE PROBABLE GCPE PROTEIN ML1581c, len: 392 aa. Probable gcpE protein. Highly similar to many GcpE orthologues the function of which is unknown. However in E. coli gcpE has been shown to be an essential gene. Similar to Escherichia coli SW:GCPE_ECOLI (P27433) (372 aa), Fasta scores: E(): 0, 45.5% identity in 330 aa overlap and Mycobacterium tuberculosis Rv2868c TR:O33350 (EMBL:AL008883) (387 aa), Fasta scores: E(): 0, 87.6% identity in 388 aa overlap. Q9CBU5 No conserved hypotheticals PF04551 Q9CBU5 GO:0046429,GO:0005506,GO:0055114,GO:0016114,GO:0051539 1.17.7.1 Rv2868c Rv2868c AL450380.2 Mycobrowser_v4 CDS 1779777 1781057 . - 0 ML1477c clpX PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX ML1477c, len: 426 aa. Probable clpX, ATP-dependent Clp protease ATP-binding subunit (EC 3.4.-.-). Highly similar to many ATP-dependent Clp protease ATP-binding subunits e.g. Bacillus subtilis SW:CLPX_BACSU (P50866) (420 aa), Fasta scores: E(): 0, 63.4% identity in 426 aa overlap and Mycobacterium tuberculosis Rv2457c SW:CLPX_MYCTU (O53184) (426 aa), Fasta scores: E(): 0, 96.0% identity in 426 aa overlap. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBY6 No intermediary metabolism and respiration PF06689,PF07724,PF10431 Q9CBY6 GO:0016887,GO:0046983,GO:0006457,GO:0015031,GO:0051082,GO:0008270,GO:0005524 Rv2457c Rv2457c AL450380.2 Mycobrowser_v4 CDS 2670329 2671879 . + 0 ML2247 cpsA POSSIBLE CONSERVED PROTEIN CPSA ML2247, len: 516 aa. Possible cpsA, conserved protein. Similar to Mycobacterium tuberculosis cpsa CPSA OR Rv3484 OR MTCY13E12.37 TR:O06347 (EMBL:Z95390) fasta scores: E(): 0, 74.9% identity in 518 aa, and to Streptococcus agalactiae cpsx protein CPSX TR:Q9S2Z3 (EMBL:Y17241) fasta scores: E(): 1.9e-09, 26.0% identity in 254 aa, and to Streptomyces coelicolor putative transcriptional regulator SC6G4.33 TR:O86796 (EMBL:AL031317) fasta scores: E(): 4.6e-09, 27.2% identity in 327 aa. Q50160 No conserved hypotheticals PF03816 Q50160 Rv3484 Rv3484 AL450380.2 Mycobrowser_v4 CDS 1797616 1800207 . - 0 ML1492c fbiC PROBABLE F420 BIOSYNTHESIS PROTEIN FBIC ML1492c, len: 863 aa. Probable fbiC, F420 biosynthesis protein. Highly similar to Mycobacterium tuberculosis TR:O50429 (EMBL:AL010186) Probable fbiC, F420 biosynthesis protein (856 aa), Fasta scores: E(): 0, 88.3% identity in 846 aa overlap. And similar to many proteins of undefined function including: Streptomyces coelicolor TR:CAB88436 (EMBL:AL353815) (867 aa), Fasta scores: E(): 0, 62.5% identity in 839 aa overlap and Q9CBX6 No intermediary metabolism and respiration PF04055 Q9CBX6 GO:0009108,GO:0005506,GO:0016765,GO:0051539 2.5.1.- Rv1173 Rv1173 AL450380.2 Mycobrowser_v4 CDS 1584499 1587261 . + 0 ML1333 helY PROBABLE ATP-DEPENDENT DNA HELICASE HELY ML1333, len: 920 aa. Probable helY, DNA helicase (EC 3.6.1.-). Highly similar to many proposed Prokaryotic and Eukaryotic helicases including: Mycobacterium tuberculosis Rv2092c SW:HELY_MYCTU (Q10701) (906 aa), Fasta scores: E(): 0, 82.5% identity in 922 aa overlap and Saccharomyces cerevisiae ATP-dependent RNA helicase Dob1 SW:MTR4_YEAST (P47047) (1073 aa), Fasta scores: E(): 0, 27.2% identity in 972 aa overlap. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9ZBD8 No information pathways PF00270,PF00271,PF08148 Q9ZBD8 GO:0008026,GO:0003676,GO:0005524 3.6.1.- Rv2092c Rv2092c AL450380.2 Mycobrowser_v4 CDS 1606117 1609125 . + 0 ML1346 ML1346 possible long-chain acyl-CoA synthase ML1346, len: 1002 aa. Possible long-chain acyl-CoA synthase. Similar to many Prokaryotic and Eukaryotic long-chain acyl-CoA synthetases including: Mus musculus SW:VLCS_MOUSE (O35488) (620 aa), Fasta scores: E(): 1.5e-20, 24.7% identity in 570 aa overlap and Chromatium vinosum poly-beta-hydroxybutyrate polymerase (EC 2.3.1.-) SW:PHBC_CHRvI (P45370) (355 aa), Fasta scores: E(): 4.7e-17, 28.2% identity in 348 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1683 TR:O33185 (EMBL:Z98268) (999 aa), Fasta scores: E(): 0, 85.6% identity in 1002 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00120 Lipases. Q9CC34 No lipid metabolism PF00501,PF00561 Q9CC34 GO:0008152,GO:0003824 Rv1683 Rv1683 AL450380.2 Mycobrowser_v4 CDS 1628033 1628896 . + 0 ML1367 ML1367 PUTATIVE INITIATION INHIBITOR PROTEIN ML1367, len: 287 aa. Putative initiation inhibitor protein, a soj-related protein probably involved in cell process, similar to several proteins involved in plasmid/chromosome partioning or regulation of sporulation e.g. Neisseria meningitidis ParA family protein TR:CAB83392 (EMBL:AL162752) (257 aa), Fasta scores: E(): 0, 42.1% identity in 252 aa overlap and Bacillus subtilis SW:SOJ_BACSU (P37522) (253 aa), Fasta scores: E(): 0, 46.2% identity in 247 aa overlap, respectively. Also highly similar to Mycobacterium tuberculosis Rv1708 TR:O33207 (EMBL:Z98268) (318 aa), Fasta scores: E(): 0, 89.5% identity in 286 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATPase. Contains Pfam match to entry PF00142 fer4_NifH, 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family. Q9CC29 No cell wall and cell processes PF01656 Q9CC29 GO:0042242,GO:0009236 Rv1708 Rv1708 AL450380.2 Mycobrowser_v4 CDS 1568248 1570077 . + 0 ML1316 mpa Probable mycobacterium proteasome ATPase Mpa ML1316, len: 609 aa. Probable mpa, mycobacterium proteasome ATPase (see Darwin et al., 2003) Highly similar to Mycobacterium tuberculosis mpa, proteasome ATPase Rv2115c SW:YL15_MYCTU (O33250) (609 aa), Fasta scores: E(): 0, 92.8% identity in 609 aa overlap. And many AAA ATPase-family proteins including: Rhodococcus erythropolis ARC protein TR:O50202 (EMBL:AF088800) (591 aa), Fasta scores: E(): 0, 81.8% identity in 588 aa overlap, Methanococcus jannaschii cell division cycle protein SW:YB56_METJA (Q58556) (903 aa), Fasta scores: E(): 1.6e-17, 46.8% identity in 250 aa overlap. Contains possible coiled-coils between residues 76..98. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00674 AAA-protein family signature. P46509 No cell wall and cell processes PF00004 P46509 GO:0017111,GO:0005524 Rv2115c Rv2115c AL450380.2 Mycobrowser_v4 CDS 1734473 1736407 . - 0 ML1441c ppm1b Polyprenol-monophosphomannose synthase Ppm1b ML1441c, len: 644 aa. Probable ppm1b, Polyprenol-monophosphomannose synthase. Highly similar to the N-terminus of a Polyprenol-monophosphomannose synthase from Mycobacterium tuberculosis Rv2051c TR:O53493 (EMBL:AL021899) (874 aa), Fasta scores: E(): 0, 67.7% identity in 601 aa overlap. Homology to Rv2051c continues downstream of this ORF in a different frame suggesting a possible frameshift. Also similar to several apolipoprotein N-acyltransferases (EC 2.3.1.-) involved in lipoprotein biosynthesis e.g. Rhizobium meliloti SW:LNT_RHIME (Q52910) (541 aa), Fasta scores: E(): 1.3e-08, 26.0% identity in 515 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase. Q7AQ49 No cell wall and cell processes PF00795 Q7AQ49 GO:0016810,GO:0016021,GO:0042158,GO:0006807,GO:0005886,GO:0016410 Rv2051c Rv2051c AL450380.2 Mycobrowser_v4 CDS 1598386 1599192 . - 0 ML1340c ribD INVOLVED IN RIBOFLAVIN BIOSYNTHESIS (AT THE SECOND AND THIRD STEPS). CONVERTS 2,5-DIAMINO-6-(RIBOSYLAMINO)-4(3H)-PYRIMIDINONE 5'-PHOSPHATE INTO 5-AMINO-6-(RIBOSYLAMINO)-2,4(1H,3H)-PYRIMIDINEDIONE 5'-PHOSPHATE [CATALYTIC ACTIVITY 1: 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE + H(2)O = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NH(3)] [CATALYTIC ACTIVITY 2: 5-AMINO-6-(5-PHOSPHORIBITYLAMINO)URACIL + NADP(+) = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NADPH]. POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) ML1340c, len: 268 aa. Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193). Similar to Mycobacterium tuberculosis Rv2671 TR:P71968 (EMBL:Z80225) bifunctional riboflavin biosynthesis protein (258 aa), Fasta scores: E(): 0, 72.9% identity in 251 aa overlap. And similar to the C-terminal reductase domains of several riboflavin biosynthetic proteins e.g. Escherichia coli RibD SW:RIBD_ECOLI (X64395) (367 aa), Fasta scores: E(): 0.0028, 23.8% identity in 227 aa overlap. Contains Pfam match to entry PF01872 RibD_C, RibD C-terminal domain. Q7AQ62 No intermediary metabolism and respiration PF01872 Q7AQ62 GO:0009231,GO:0008703 Rv2671 Rv2671 AL450380.2 Mycobrowser_v4 CDS 1975129 1975827 . - 0 ML1638c ML1638c conserved hypothetical protein ML1638c, len: 232 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2229c SW:YM29_MYCTU (Q10513) (245 aa), Fasta scores: E(): 0, 60.9% identity in 230 aa overlap. Contains a possible coiled-coil between residues 100..139. Q9CBS9 No conserved hypotheticals PF02591 Q9CBS9 Rv2229c Rv2229c AL450380.2 Mycobrowser_v4 CDS 1661669 1663765 . + 0 ML1387 uvrB INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). UVRB STIMULATES THE ATPASE ACTIVITY OF UVRA IN THE PRESENCE OF UV-IRRADIATED DOUBLE-STRANDED DNA. IT ALSO ENHANCES THE ABILITY OF UVRA TO BIND TO UV-IRRADIATED DUPLEX DNA PROBABLE EXCINUCLEASE ABC (SUBUNIT B - HELICASE) UVRB ML1387, len: 698 aa. Probable uvrB, excinuclease ABC subunit B. Highly similar to many excinucleases ABC (subunit B), involved in DNA repair following UV damage, including: Micrococcus luteus SW:UVRB_MICLU (P10125) (709 aa), Fasta scores: E(): 0, 71.4% identity in 700 aa overlap and Mycobacterium tuberculosis Rv1633 SW:UVRB_MYCTU (O06150) (698 aa), Fasta scores: E(): 0, 94.7% identity in 698 aa overlap. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains PS00017 ATP/GTP-binding site motif A (P-loop). P57991 No information pathways PF00271,PF02151,PF04851 P57991 GO:0003677,GO:0009432,GO:0005737,GO:0009381,GO:0009380,GO:0004386,GO:0006289,GO:0005524 Rv1633 Rv1633 AL450380.2 Mycobrowser_v4 CDS 2761710 2762480 . + 0 ML2331 ML2331 possible secreted protein ML2331, len: 256 aa. Possible secreted protein. Similar to Mycobacterium tuberculosis hypothetical 24.8 kDa protein Rv3717 TR:O69684 (EMBL:AL022121) (241 aa) fasta scores: E(): 0, 82.0% identity in 244 aa, and to Streptomyces coelicolor putative secreted protein TR:CAB93433 (EMBL:AL357591) (336 aa) fasta scores: E(): 1.5e-24, 38.8% identity in 242 aa. Note contains a Pfam match to PF01520 N-acetylmuramoyl-L-alanine amidase. Contains Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase. Contains a possible N-terminal signal sequence. Q9CB75 No cell wall and cell processes, conserved hypotheticals PF01520 Q9CB75 GO:0009253,GO:0008745 Rv3717 Rv3717 AL450380.2 Mycobrowser_v4 CDS 1880183 1882957 . - 0 ML1556c infB IF-2, ONE OF THE ESSENTIAL COMPONENTS FOR THE INITIATION OF PROTEIN SYNTHESIS IN VITRO, PROTECTS FORMYLMETHIONYL-TRNA FROM SPONTANEOUS HYDROLYSIS AND PROMOTES ITS BINDING TO THE 30S RIBOSOMAL SUBUNITS. IT IS ALSO INVOLVED IN THE HYDROLYSIS OF GTP DURING THE FORMATION OF THE 70S RIBOSOMAL COMPLEX. PROBABLE TRANSLATION INITIATION FACTOR IF-2 INFB ML1556c, len: 924 aa. Probable infB, initiation factor IF-2. Highly similar to Mycobacterium tuberculosis SW:IF2_MYCTU (P71613) (900 aa), Fasta scores: E(): 0, 83.6% identity in 933 aa overlap. Similar in the C-terminus to many translation initiation factors e.g. Bacillus subtilis SW:IF2_BACSU (P17889) (716 aa), Fasta scores: E(): 0, 45.5% identity in 686 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains Pfam match to entry PF02131 IF2, Initiation factor 2. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9Z5I9 No information pathways PF00009,PF03144,PF04760 Q9Z5I9 GO:0003924,GO:0005737,GO:0003743,GO:0006413,GO:0005525 Rv2839c Rv2839c AL450380.2 Mycobrowser_v4 CDS 1871005 1871967 . - 0 ML1546c truB PROBABLE TRNA PSEUDOURIDINE SYNTHASE B TRUB (TRNA PSEUDOURIDINE 55 SYNTHASE) (PSI55 SYNTHASE) (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE) ML1546c, len: 320 aa. Probable tRNA pseudouridine 55 synthase (EC 4.2.1.70). Highly similar to many tRNA pseudouridine synthases B including: Escherichia coli SW:TRUB_ECOLI (X13270) (314 aa), Fasta scores: E(): 1.7e-19, 36.4% identity in 316 aa overlap and Mycobacterium tuberculosis Rv2793c SW:TRUB_MYCTU (O33335) (298 aa), Fasta scores: E(): 0, 74.1% identity in 293 aa overlap. Contains Pfam match to entry PF01509 TruB_N, TruB family pseudouridylate synthase (N terminal domain). Q9Z5I4 No information pathways PF01509,PF09142 Q9Z5I4 GO:0031119,GO:0009982 5.4.99.- Rv2793c Rv2793c AL450380.2 Mycobrowser_v4 CDS 1877248 1878690 . + 0 ML1553 proS Probable prolyl tRNA synthetase ProS ML1553, len: 480 aa. Probable proS, prolyl-tRNA synthetase (EC 6.1.1.15). Highly similar to many prolyl tRNA synthetases including: SYP_CLOST|Q9L4Q8 from Clostridium sticklandii (481 aa), Fasta scores: E(): 0, (46.5% identity in 477 aa overlap) and to parts of the Eukaryotic multifunctional aminoacyl-tRNA synthetases such as Homo sapiens (Human) SYEP_HUMAN|P07814 (1440 aa), Fasta scores: E(): 0, (44.5% identity in 467 aa overlap). Note codon 8 may offer an alternative translational start site. Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). Belongs to class-II aminoacyl-tRNA synthetase family. Q9Z5I7 No information pathways PF00587,PF03129,PF09180 Q9Z5I7 GO:0005737,GO:0004827,GO:0006433,GO:0005524 6.1.1.15 AL450380.2 Mycobrowser_v4 CDS 1901941 1903767 . - 0 ML1577c ML1577c POSSIBLE PENICILLIN-BINDING LIPOPROTEIN ML1577c, len: 608 aa. Probable penicillin binding protein. Similar to many penicillin binding proteins e.g. Streptomyces clavuligerus high molecular weight group B penicillin binding protein TR:P72405 (EMBL:U56256) (551 aa), Fasta scores: E(): 6.3e-27, 29.9% identity in 609 aa overlap and Mycobacterium tuberculosis Rv2864c SW:O33346. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CBU6 No cell wall and cell processes PF00905,PF05223 Q9CBU6 GO:0009273,GO:0046677,GO:0008658 Rv2864c Rv2864c AL450380.2 Mycobrowser_v4 CDS 2451096 2452046 . + 0 ML2064 blaR CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN ML2064, len: 316 aa. Conserved hypothetical transmembrane protein. Similar to Mycobacterium tuberculosis transmembrane protein Rv1845c TR:P95164 (EMBL:Z83859) fasta scores: E(): 0, 87.6% in 314 aa, and to Streptomyces coelicolor putative integral membrane protein SC10A7.04 TR:Q9XAS1 (EMBL:AL078618) fasta scores: E(): 1.8e-19, 32.6% in 328 aa. Q7APZ7 No cell wall and cell processes PF01435 Q7APZ7 GO:0004222,GO:0006508,GO:0008270,GO:0016020 Rv1845c Rv1845c AL450380.2 Mycobrowser_v4 CDS 1886300 1887904 . - 0 ML1562c efpA POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA ML1562c, len: 534 aa. Possible efpA, integral membrane efflux protein. Highly similar to several transmembrane transport proteins including: Streptomyces lipmanii SW:PUR8_STRLP (P42670) (503 aa), Fasta scores: E(): 0, 33.3% identity in 481 aa overlap and Mycobacterium tuberculosis Rv2846c TR:O05813 (EMBL:Z95207) (530 aa), Fasta scores: E(): 0, 86.5% identity in 535 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter. Q7AQ40 No cell wall and cell processes PF07690 Q7AQ40 GO:0016021 Rv2846c Rv2846c AL450380.2 Mycobrowser_v4 CDS 1906998 1908212 . - 0 ML1582c ML1582c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML1582c, len: 404 aa. Probable conserved transmembrane protein. Similar to many including several putative metalloproteases e.g. Treponema pallidum TR:O83609 (EMBL:AE001235) (450 aa), Fasta scores: E(): 1.6e-10, 27.5% identity in 265 aa overlap and several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2869c TR:O33351 (EMBL:AL008883) (404 aa), Fasta scores: E(): 0, 82.2% identity in 404 aa overlap. Contains possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Q9CBU4 No cell wall and cell processes PF02163 Q9CBU4 GO:0004222,GO:0005886,GO:0005515,GO:0006508,GO:0008270,GO:0016021 3.4.24.- Rv2869c Rv2869c AL450380.2 Mycobrowser_v4 CDS 1975873 1977030 . - 0 ML1639c ML1639c conserved hypothetical protein ML1639c, len: 385 aa. Conserved hypothetical protein. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2230c SW:YM30_MYCTU (Q10514) (379 aa), Fasta scores: E(): 0, 79.5% identity in 385 aa overlap. Contains Pfam match to entry PF01784 DUF34, Domain of unknown function. O69481 No conserved hypotheticals PF01784 O69481 Rv2230c Rv2230c AL450380.2 Mycobrowser_v4 CDS 2066954 2068522 . + 0 ML1714 ML1714 conserved hypothetical protein ML1714, len: 522 aa. Conserved hypothetical protein. Highly similar to several proteins of unknown function including: Mycobacterium tuberculosis hypothetical protein Rv3031 TR:O53278 (EMBL:AL021287) (526 aa), Fasta scores: E(): 0, 86.3% identity in 526 aa overlap and Pyrococcus abyssi TR:Q9V0M7 (EMBL:AJ248285) (602 aa), Fasta scores: E(): 2.7e-22, 30.0% identity in 556 aa overlap. Q9CBR4 No conserved hypotheticals PF03065,PF09210 Q9CBR4 GO:0003824,GO:0005975 Rv3031 Rv3031 AL450380.2 Mycobrowser_v4 CDS 2347451 2347564 . - 0 ML1961c rpmJ PROBABLE 50S RIBOSOMAL PROTEIN L36 RPMJ ML1961c, len: 37 aa. Probable rpmJ, 50S ribosomal protein L36. Similar to M. tuberculosis 50S ribosomal protein L36 rpmJ Rv3461c SW:RL36_MYCTU (P45810) (37 aa), Fasta scores: E(): 1e-15, 86.5% identity in 37 aa overlap. Contains PS00828 Ribosomal protein L36 signature. Q9X7A2 No information pathways PF00444 Q9X7A2 GO:0003735,GO:0006412,GO:0005840 Rv3461c Rv3461c AL450380.2 Mycobrowser_v4 CDS 2692771 2693568 . + 0 ML2269 bpoC POSSIBLE PEROXIDASE BPOC (NON-HAEM PEROXIDASE) ML2269, len: 265 aa. Possible bpoC, peroxidase (EC 1.11.1.-). Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% identity in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% identity in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1.6e-13, 29.5% identity in 275 aa. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Q9CBB1 No virulence, detoxification, adaptation PF00561 Q9CBB1 GO:0016787 Rv0554 Rv0554 AL450380.2 Mycobrowser_v4 CDS 2557045 2559306 . + 0 ML2156 ML2156 CONSERVED HYPOTHETICAL PROTEIN ML2156, len: 753 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0862c hypothetical 79.7 kda protein TR:O53874 (EMBL:AL022004) fasta scores: E(): 0, 77.6% in 753 aa, and to Streptomyces coelicolor hypothetical 90.4 kda protein TR:CAB93395 (EMBL:AL357524) fasta scores: E(): 3.9e-27, 34.6% in 856 aa. Contains a probable helix-turn-helix motif at aa 277-298 (Score 1075, SD +2.85) Q9CBE1 No conserved hypotheticals Q9CBE1 GO:0003677 Rv0862c Rv0862c AL450380.2 Mycobrowser_v4 CDS 2469475 2469873 . - 0 ML2077c gcvH PROBABLE GLYCINE CLEAVAGE SYSTEM H PROTEIN GCVH ML2077c, len: 132 aa. Probable gcvH, glycine cleavage system H protein. Similar to Mycobacterium tuberculosis probable glycine cleavage system H protein SW:GCSH_MYCTU (Q50607) fasta scores: E(): 0, 78.4% in 134 aa, and to Escherichia coli glycine cleavage system H protein SW:GCSH_ECOLI (P23884) fasta scores: E(): 1.5e-22, 49.6% in 129 aa. Contains Pfam match to entry PF01597 GCV_H, Glycine cleavage H-protein. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. O32920 No intermediary metabolism and respiration PF01597 O32920 GO:0019464,GO:0031405,GO:0005960 Rv1826 Rv1826 AL450380.2 Mycobrowser_v4 CDS 2586148 2586552 . + 0 ML2174 cdd PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) ML2174, len: 134 aa. Probable cdd, cytidine deaminase (EC 3.5.4.5). Similar to Mycobacterium tuberculosis cytidine deaminase Rv3315c TR:O53367 (EMBL:AL021841) fasta scores: E(): 3e-28, 56.8% in 132 aa, and to Mus musculus cytidine deaminase SW:CDD_MOUSE (P56389) fasta scores: E(): 5.2e-12, 39.8% in 118 aa. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. Q9CBD3 No intermediary metabolism and respiration PF00383 Q9CBD3 GO:0046087,GO:0008270,GO:0004126 Rv3315c Rv3315c AL450380.2 Mycobrowser_v4 CDS 2009608 2010252 . - 0 ML1666c ML1666c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN ML1666c, len: 214 aa. Probable conserved integral membrane protein. Similar to several proteins of undefined function including: Streptomyces coelicolor putative integral membrane protein TR:CAB93387 (EMBL:AL357523) (240 aa), Fasta scores: E(): 3.6e-25, 36.1% identity in 191 aa overlap and Mycobacterium tuberculosis Rv2968c TR:P95126 (EMBL:Z83018) (210 aa), Fasta scores: E(): 0, 72.4% identity in 214 aa overlap. Contains possible membrane spanning hydrophobic domains. Q7AQ31 No cell wall and cell processes PF07884 Q7AQ31 Rv2968c Rv2968c AL450380.2 Mycobrowser_v4 CDS 2381503 2383101 . + 0 ML1994 fadD10 POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) ML1994, len: 532 aa. Possible fadD10, fatty-acid-CoA synthetase (EC 6.2.1.-). Similar to Mycobacterium tuberculosis putative fatty-acid-CoA synthases e.g. Rv0099 or MTCY251.18 TR:Q10878 (EMBL:Z74410) (540 aa) fasta scores: E(): 0, 74.6% identity in 531 aa. Previously sequenced as TR:Q50176 (EMBL:Z46257). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Q50176 No lipid metabolism PF00501 Q50176 GO:0008152,GO:0016874 Rv0099 Rv0099 AL450380.2 Mycobrowser_v4 CDS 2311565 2312068 . - 0 ML1926c ML1926c putative tuberculin related peptide (AT103) ML1926c, len: 167 aa. Putative tuberculin related peptide (AT103). Similar to M. tuberculosis tuberculin related peptide (AT103) Rv0431 TR:P96277 (EMBL:Z84724) (164 aa), Fasta scores: E(): 1.6e-32, 67.5% identity in 163 aa overlap and TR:O69619 (EMBL:D00815) (172 aa), Fasta scores: E(): 1.5e-32, 67.1% identity in 164 aa overlap. Q9CBI5 No cell wall and cell processes Q9CBI5 Rv0431 Rv0431 AL450380.2 Mycobrowser_v4 CDS 2865946 2867340 . - 0 ML2396c cbs Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) ML2396c, len: 464 aa. Probable cbs (previously cysM2), cystathionine beta-synthase (EC 4.2.1.22). Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% identity in 479 aa. Also similar to ML0839 from M. leprae. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Previously known as cysM2. Q9CB65 No intermediary metabolism and respiration PF00291,PF00571 Q9CB65 GO:0019343,GO:0005737,GO:0030170,GO:0004122 Rv1077 Rv1077 AL450380.2 Mycobrowser_v4 CDS 1953455 1954747 . - 0 ML1628c ftsY PROBABLE CELL DIVISION PROTEIN FTSY (SRP RECEPTOR) (SIGNAL RECOGNITION PARTICLE RECEPTOR) ML1628c, len: 430 aa. Probable ftsY, cell division protein. Highly similar to the C-terminal portion of many proposed SRP family cell division proteins: Escherichia coli FtsY SW:FTSY_ECOLI (P10121) (497 aa), Fasta scores: E(): 0, 40.5% identity in 338 aa overlap. Also highly similar over the entire range to Mycobacterium tuberculosis Rv2921c SW:FTSY_MYCTU (Q10969) (422 aa), Fasta scores: E(): 0, 81.4% identity in 429 aa overlap. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00448 SRP54, SRP54-type protein. Contains PS00300 SRP54-type proteins GTP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O33010 No cell wall and cell processes PF00448,PF02881 O33010 GO:0005525,GO:0006614,GO:0007049,GO:0051301,GO:0017111,GO:0005886,GO:0048500,GO:0008312 Rv2921c Rv2921c AL450380.2 Mycobrowser_v4 CDS 2450663 2451091 . + 0 ML2063 blaI POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN ML2063, len: 142 aa. Possible transcriptional regulatory protein. Similar to Mycobacterium tuberculosis transcriptional regulatory protein Rv1846c TR:P95163 (EMBL:AL008609) fasta scores: E(): 0, 95.1% in 123 aa, and weakly to Bacillus licheniformis penicillinase repressor SW:BLAI_BACLI (P06555; P12286) fasta scores: E(): 1.1, 21.7% in 129 aa. Q7APZ8 No regulatory proteins PF03965 Q7APZ8 GO:0016481,GO:0016566,GO:0003677 Rv1846c Rv1846c AL450380.2 Mycobrowser_v4 CDS 2683154 2684398 . - 0 ML2260c pitA PROBABLE LOW-AFFINITY INORGANIC PHOSPHATE TRANSPORTER INTEGRAL MEMBRANE PROTEIN PITA ML2260c, len: 414 aa. Probable pitA, low-affinity inorganic phosphate transporter integral membrane protein. Similar to Mycobacterium tuberculosis probable low-affinity inorganic phosphate transporter PIT OR PITA OR Rv0545c OR MTCY25D10.24C SW:PIT_MYCTU (O06411) fasta scores: E(): 0, 76.3% identity in 418 aa, and to Bacillus subtilis probable low-affinity inorganic phosphate transporter PIT SW:PIT_BACSU (O34436) fasta scores: E(): 0, 43.9% identity in 312 aa. Contains Pfam match to entry PF01384 PHO4, Phosphate transporter family. Contains possible membrane spanning hydrophobic domains. Q50173 No cell wall and cell processes PF01384 Q50173 GO:0016021,GO:0006817,GO:0005886,GO:0005315 Rv0545c Rv0545c AL450380.2 Mycobrowser_v4 CDS 2129664 2131040 . - 0 ML1755c sdaA PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE DEAMINASE) (SDH) (L-SD) ML1755c, len: 458 aa. Probable sdaA, L-serine dehydratase (EC 4.2.1.13). Highly similar to many L-serine dehydratases including: Escherichia coli SW:TDCG_ECOLI (P42630) (454 aa), Fasta scores: E(): 0, 53.2% identity in 457 aa overlap and Mycobacterium tuberculosis Rv0069c SW:SDHL_MYCTU (O53614) (461 aa), Fasta scores: E(): 0, 69.2% identity in 461 aa overlap. Q9CBP2 No intermediary metabolism and respiration PF03313,PF03315 Q9CBP2 GO:0003941,GO:0006094,GO:0051539 Rv0069c Rv0069c AL450380.2 Mycobrowser_v4 CDS 2037162 2038172 . - 0 ML1691c leuB PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) ML1691c, len: 336 aa. Probable leuB, 3-isopropylmalate dehydrogenase (EC 1.1.1.85). Highly similar to 3-isopropylmalate dehydrogenases, involved in leucine biosynthesis, from Mycobacterium bovis SW:LEU3_MYCBO (P94929) (336 aa), Fasta scores: E(): 0, 83.9% identity in 336 aa overlap and Mycobacterium tuberculosis Rv2995c SW:LEU3_MYCTU (P95313) (336 aa), Fasta scores: E(): 0, 83.9% identity in 336 aa overlap. Contains Pfam match to entry PF00180 isodh, Isocitrate and isopropylmalate dehydrogenases. O33117 No intermediary metabolism and respiration PF00180 O33117 GO:0051287,GO:0005737,GO:0009098,GO:0000287,GO:0030145,GO:0055114,GO:0003862 1.1.1.85 Rv2995c Rv2995c AL450380.2 Mycobrowser_v4 CDS 2721471 2722016 . + 0 ML2296 ML2296 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2296, len: 181 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv3669 or MTV025.017 TR:O69637 (EMBL:AL022121) (172 aa) fasta scores: E(): 0, 77.9% identity in 181 aa. Similar to Streptomyces coelicolor putative integral membrane transport protein SCH5.28 TR:Q9X930 (EMBL:AL035636) (162 aa) fasta scores: E(): 3.3e-10, 37.3% identity in 153 aa, and to putative integral membrane protein SCI7.29C TR:Q9X9W1 (EMBL:AL096743) (165 aa) fasta scores: E(): 1.1e-05, 32.1% identity in 134 aa. Contains hydrophobic, possible membrane-spanning regions. Q9CB97 No cell wall and cell processes PF07332 Q9CB97 Rv3669 Rv3669 AL450380.2 Mycobrowser_v4 CDS 2220763 2222079 . - 0 ML1833c secY PROBABLE PREPROTEIN TRANSLOCASE SECY ML1833c, len: 438 aa. Probable secY, preprotein translocase. Similar to M. tuberculosis preprotein translocase secy subunit Rv0732 SW:SECY_MYCTU (P94926) (441 aa), Fasta scores: E(): 0, 91.6% identity in 441 aa overlap, and to many others e.g. Bacillus subtilis SW:SECY_BACSU (P16336) (431 aa), Fasta scores: E(): 0, 42.7% identity in 445 aa overlap. Contains Pfam match to entry PF00344 secY, eubacterial secY protein. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00756 Protein secY signature 2. O33006 No cell wall and cell processes PF00344 O33006 GO:0016021,GO:0065002,GO:0005886,GO:0015450 Rv0732 Rv0732 AL450380.2 Mycobrowser_v4 CDS 1923194 1924027 . - 0 ML1598c rpsB PROBABLE 30S RIBOSOMAL PROTEIN S2 RPSB ML1598c, len: 277 aa. Probable rpsB, 30S ribosomal protein S2. Highly similar to many 30s ribosomal proteins (S2) including: Bacillus subtilis SW:RS2_BACSU (P21464) (245 aa), Fasta scores: E(): 0, 57.6% identity in 250 aa overlap and Mycobacterium tuberculosis Rv2890c SW:RS2_MYCTU (Q10796) (287 aa), Fasta scores: E(): 0, 91.5% identity in 270 aa overlap. Contains Pfam match to entry PF00318 Ribosomal_S2, Ribosomal protein S2. Contains PS00962 Ribosomal protein S2 signature 1. O33038 No information pathways PF00318 O33038 GO:0003735,GO:0006412,GO:0015935 Rv2890c Rv2890c AL450380.2 Mycobrowser_v4 CDS 1922362 1923192 . - 0 ML1597c tsf PROBABLE ELONGATION FACTOR TSF (EF-TS) ML1597c, len: 276 aa. Probable tsf, elongation factor (EF-Ts). Highly similar to many elongation factors including: Streptomyces coelicolor SW:EFTS_STRCO (O31213) (278 aa), Fasta scores: E(): 0, 52.5% identity in 282 aa overlap and Mycobacterium tuberculosis Rv2889c SW:EFTS_MYCTU (Q10788) (271 aa), Fasta scores: E(): 0, 83.7% identity in 276 aa overlap. Contains Pfam match to entry PF02094 TS-N, TS-N domain. Contains Pfam match to entry PF00889 EF_TS, Elongation factor TS. Contains PS01127 Elongation factor Ts signature 2. Contains PS01126 Elongation factor Ts signature 1. O33039 No information pathways PF00627,PF00889 O33039 GO:0003746,GO:0006414,GO:0005737 Rv2889c Rv2889c AL450380.2 Mycobrowser_v4 CDS 1954861 1958472 . - 0 ML1629c smc PROBABLE CHROMOSOME PARTITION PROTEIN SMC ML1629c, len: 1203 aa. Probable smc, chromosome partition protein. Highly similar to many proteins involved in chromosome segregation and partition including: Bacillus subtilis Smc SW:SMC_BACSU (P51834) (1186 aa), Fasta scores: E(): 0, 31.5% identity in 1242 aa overlap and Mycobacterium tuberculosis Rv2922c SW:SMC_MYCTU (Q1097) (1205 aa), Fasta scores: E(): 0, 79.2% identity in 1208 aa overlap. Contains multiple possible coiled-coiled regions between residues 174..190, 260..279, 340..374, 397..433, 451..489, 725..754. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBT5 No cell wall and cell processes PF02463,PF06470 Q9CBT5 GO:0005694,GO:0051276,GO:0017111,GO:0005515,GO:0005524 Rv2922c Rv2922c AL450380.2 Mycobrowser_v4 CDS 2020081 2021058 . - 0 ML1676c thiL PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE) ML1676c, len: 325 aa. Probable thiL, thiamine-monophosphate kinase (EC 2.7.4.16). Similar to several thiamine-monophosphate kinases including: Escherichia coli SW:THIL_ECOLI (P77785) (325 aa), Fasta scores: E(): 1.1e-18, 35.3% identity in 278 aa overlap and Mycobacterium tuberculosis Rv2977c TR:P95118 (P95118) (333 aa), Fasta scores: E(): 0, 80.9% identity in 314 aa overlap. Contains Pfam match to entry PF00586 AIRS, AIR synthase related protein. Q9CBS2 No intermediary metabolism and respiration PF00586,PF02769 Q9CBS2 GO:0009030,GO:0009228 Rv2977c Rv2977c AL450380.2 Mycobrowser_v4 CDS 1945512 1947482 . + 0 ML1623 htpG PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) ML1623, len: 656 aa. Probable htpG, heat shock protein Hsp90 family. Highly similar to many heat shock 90 family proteins, including: Escherichia coli SW:HTPG_ECOLI (P10413) (624 aa), Fasta scores: E(): 0, 45.4% identity in 656 aa overlap and Mycobacterium tuberculosis Rv2299c SW:HTPG_MYCTU (Q50667) (647 aa), Fasta scores: E(): 0, 80.8% identity in 656 aa overlap. Contains 2 Pfam matches to entry PF00183 HSP90, Hsp90 protein. Contains PS00298 Heat shock hsp90 proteins family signature. O33012 No virulence, detoxification, adaptation PF00183,PF02518 O33012 GO:0005737,GO:0006457,GO:0006950,GO:0051082,GO:0005524 Rv2299c Rv2299c AL450380.2 Mycobrowser_v4 CDS 1964380 1965915 . - 0 ML1632c ML1632c Probable exported protease ML1632c, len: 511 aa. Probable exported protease. Highly similar to Mycobacterium tuberculosis Rv2223C SW:YM23_MYCTU (Q10508) (520 aa), Fasta scores: E(): 0, 75.8% identity in 520 aa overlap. And similar to Streptomyces lividans tripeptidylaminopeptidase precursor TR:Q54410 (EMBL:L27466) (537 aa), Fasta scores: E(): 0, 30.9% identity in 489 aa overlap. Also similar to ML1633 from M. leprae. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Q9CBT2 No cell wall and cell processes PF00561 Q9CBT2 GO:0016787 Rv2223c Rv2223c AL450380.2 Mycobrowser_v4 CDS 1999998 2000846 . - 0 ML1658c fpg INVOLVED IN BASE EXCISION REPAIR (REPAIR OF OXIDIZED PURINES). THIS ENZYME MAY PLAY A SIGNIFICANT ROLE IN PROCESSES LEADING TO RECOVERY FROM MUTAGENESIS AND/OR CELL DEATH BY ALKYLATING AGENTS [CATALYTIC ACTIVITY HYDROLYSIS OF DNA CONTAINING RING-OPENED N7-METHYLGUANINE RESIDUES, RELEASING 2,6-DIAMINO-4-HYDROXY-5-(N-METHYL)FORMAMIDOPYRIMIDE]. Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) ML1658c, len: 282 aa. Probable formamidopyrimidine-DNA glycosylase (EC 3.2.2.23). Highly similar to many formamidopyrimidine-DNA glycosylases thought to be involved in DNA repair after exposure to alkylating agents e.g. Escherichia coli SW:FPG_ECOLI (P05523) (215 aa), BlastP Expect 8.7 and Mycobacterium tuberculosis SW:FPG_MYCTU (Q10959) (289 aa), Fasta scores: E(): 0, 80.6% identity in 289 aa overlap. Contains Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase. O69470 No information pathways PF01149,PF06827,PF06831 O69470 GO:0003684,GO:0006289,GO:0008534,GO:0008270,GO:0006284 4.2.99.18,3.2.2.23 Rv2924c Rv2924c AL450380.2 Mycobrowser_v4 CDS 1994880 1996130 . + 0 ML1655 kasA INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC ACIDS SYNTHESIS); INVOLVED IN MEROMYCOLATE EXTENSION. CATALYZES THE CONDENSATION REACTION OF FATTY ACID SYNTHESIS BY THE ADDITION TO AN ACYL ACCEPTOR OF TWO CARBONS FROM MALONYL-ACP [CATALYTIC ACTIVITY: ACYL-[ACYL-CARRIER PROTEIN] + MALONYL-[ACYL-CARRIER PROTEIN] = 3-OXOACYL-[ACYL-CARRIER PROTEIN] + [ACYL-CARRIER PROTEIN] + CO(2)]. 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) ML1655, len: 416 aa. Probable kasA, 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41). Highly similar to many 3-oxoacyl-[acyl-carrier-protein] synthases II involved in fatty acid biosynthesis including: Escherichia coli SW:FABF_ECOLI (P39435) (412 aa), Fasta scores: E(): 0, 41.1% identity in 411 aa overlap and Mycobacterium tuberculosis Rv2245 SW:FAB1_MYCTU (Q10524) (416 aa), Fasta scores: E(): 0, 92.5% identity in 416 aa overlap. Also highly similar to the adjoining CDS ML1655. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Q9CBS7 No lipid metabolism PF00109,PF02801 Q9CBS7 GO:0005737,GO:0006633,GO:0004315 2.3.1.41 Rv2245 Rv2245 AL450380.2 Mycobrowser_v4 CDS 2025422 2027641 . + 0 ML1681 ppk PROBABLE POLYPHOSPHATE KINASE PPK (POLYPHOSPHORIC ACID KINASE) (ATP-POLYPHOSPHATE PHOSPHOTRANSFERASE) ML1681, len: 739 aa. Probable ppk, polyphosphate kinase (EC 2.7.4.1). Highly similar to many polyphosphate kinases including: Escherichia coli SW:PPK_ECOLI (P28688) (687 aa), Fasta scores: E(): 0, 34.4% identity in 655 aa overlap and Mycobacterium tuberculosis Rv2984 TR:P95111 (EMBL:Z83018) (742 aa), Fasta scores: E(): 0, 87.9% identity in 742 aa overlap. O33127 No intermediary metabolism and respiration PF02503 O33127 GO:0006799,GO:0008976,GO:0009358,GO:0005524 2.7.4.1 Rv2984 Rv2984 AL450380.2 Mycobrowser_v4 CDS 2054614 2054913 . - 0 ML1703c gatC COMPONENT OF THE TRANSLATIONAL APPARATUS. FURNISHES A MEANS FOR FORMATION OF CORRECTLY CHARGED GLN-TRNA(GLN) THROUGH THE TRANSAMIDATION OF MISACYLATED GLU- TRNA(GLN) IN ORGANISMS WHICH LACK GLUTAMINYL-TRNA SYNTHETASE. THE REACTION TAKES PLACE IN THE PRESENCE OF GLUTAMINE AND ATP THROUGH AN ACTIVATED GAMMA-PHOSPHO-GLU-TRNA(GLN) [CATALYTIC ACTIVITY: ATP + L-GLUTAMYL-TRNA(GLN) + L-GLUTAMINE = ADP + PHOSPHATE + L-GLUTAMINYL-TRNA(GLN) + L-GLUTAMATE]. PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT C) GATC (Glu-ADT SUBUNIT C) ML1703c, len: 99 aa. Probable gatC, glutamyl-tRNA(Gln) amidotransferase, subunit C (EC 6.3.5.-). Highly similar to many glutamyl-tRNA(Gln) amidotransferases (subunit C) including: Bacillus subtilis SW:GATC_BACSU (O06492) (96 aa), Fasta scores: E(): 6.9e-08, 37.9% identity in 95 aa overlap and Mycobacterium tuberculosis Rv3012c SW:GATC_MYCTU (O53259) (99 aa), Fasta scores: E(): 3.1e-28, 74.7% identity in 99 aa overlap. O33104 No information pathways PF02686 O33104 GO:0050567,GO:0006450,GO:0006412,GO:0005524 6.3.5.- Rv3012c Rv3012c AL450380.2 Mycobrowser_v4 CDS 2060896 2062128 . - 0 ML1708c iscS PROBABLE CYSTEINE DESULFURASE ISCS (NIFS PROTEIN HOMOLOG) (NITROGENASE METALLOCLUSTERS BIOSYNTHESIS PROTEIN NIFS) ML1708c, len: 410 aa. Probable iscS (alternate gene name: nifS), cysteine desulfurase (NifS-like protein) (EC 4.4.1.-). Highly similar to Mycobacterium tuberculosis NifS-like protein Rv3025c TR:O53272 (EMBL:AL021287) (393 aa), Fasta scores: E(): 0, 84.9% identity in 391 aa overlap and many aminotransferases resembling NifS e.g. Azotobacter vinelandii SW:NIFS_AZOVI (P05341) (402 aa), Fasta scores: E(): 0, 39.1% identity in 394 aa overlap. Also similar to ML0596 from M. leprae. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V. Q9CBR5 No intermediary metabolism and respiration PF00266 Q9CBR5 GO:0030170,GO:0008483,GO:0008152 Rv3025c Rv3025c AL450380.2 Mycobrowser_v4 CDS 2068548 2069864 . + 0 ML1715 ML1715 POSSIBLE TRANSFERASE ML1715, len: 438 aa. Possible transferase. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis hypothetical protein Rv3032 TR:O53279 (EMBL:AL021287) (414 aa), Fasta scores: E(): 0, 87.9% identity in 414 aa overlap. Also similar to a putative transferase from Streptomyces coelicolor TR:Q9Z5B7 (EMBL:AL035478) (406 aa), Fasta scores: E(): 2.8e-22, 30.1% identity in 415 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. Q9CBR3 No intermediary metabolism and respiration PF00534 Q9CBR3 GO:0016757,GO:0009058 Rv3032 Rv3032 AL450380.2 Mycobrowser_v4 CDS 2242938 2243594 . - 0 ML1863c rplC PROBABLE 50S RIBOSOMAL PROTEIN L3 RPLC ML1863c, len: 218 aa. Probable rplC, 50S ribosomal protein L3. Similar to M. tuberculosis 50S ribosomal protein L3 Rv0701 SW:RL3_MYCTU (P95049) (217 aa), Fasta scores: E(): 0, 93.5% identity in 217 aa overlap. Contains Pfam match to entry PF00297 Ribosomal_L3, Ribosomal protein L3. Contains PS00474 Ribosomal protein L3 signature. P30762 No information pathways PF00297 P30762 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0701 Rv0701 AL450380.2 Mycobrowser_v4 CDS 2083355 2084590 . - 0 ML1727c serB2 PROBABLE PHOSPHOSERINE PHOSPHATASE SERB2 (PSP) (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE) ML1727c, len: 411 aa. Probable serB2, Phosphoserine phosphatase (EC 3.1.3.3). Similar in the C-terminus to many phosphoserine phosphatases including: Escherichia coli SW:SERB_ECOLI (P06862) (322 aa), Fasta scores: E(): 1.7e-29, 38.5% identity in 309 aa overlap and Mycobacterium tuberculosis Rv3042c TR:O53289 (EMBL:AL021287) (409 aa), Fasta scores: E(): 0, 86.3% identity in 408 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. Q9CBQ6 No intermediary metabolism and respiration PF00702,PF01842 Q9CBQ6 GO:0016597,GO:0004647,GO:0006564 Rv3042c Rv3042c AL450380.2 Mycobrowser_v4 CDS 2090620 2091597 . - 0 ML1731c nrdF INVOLVED IN THE DNA REPLICATION PATHWAY. CATALYZES THE BIOSYNTHESIS OF DEOXYRIBONUCLEOTIDES FROM THE CORRESPONDING RIBONUCLEOTIDES, PRECURSORS THAT ARE NECESSARY FOR DNA SYNTHESIS [CATALYTIC ACTIVITY: 2'-DEOXYRIBONUCLEOSIDE DIPHOSPHATE + OXIDIZED THIOREDOXIN + H(2)O = RIBONUCLEOSIDE DIPHOSPHATE + REDUCED THIOREDOXIN]. RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) ML1731c, len: 325 aa. Probable nrdF, ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1). Highly similar to many ribonucleoside-diphosphate reductase 2 beta chains, involved in DNA replication, including: Escherichia coli SW:RIR4_ECOLI (P37146) (319 aa), Fasta scores: E(): 0, 71.6% identity in 320 aa overlap and Mycobacterium tuberculosis Rv3048c TR:Q50549 (EMBL:AL021287) (324 aa), Fasta scores: E(): 0, 93.5% identity in 324 aa overlap. Contains Pfam match to entry PF00268 ribonuc_red, Ribonucleotide reductases. Contains PS00368 Ribonucleotide reductase small subunit signature. Q9CBQ2 No information pathways PF00268 Q9CBQ2 GO:0009186,GO:0005506,GO:0055114,GO:0004748,GO:0006260 1.17.4.1 Rv3048c Rv3048c AL450380.2 Mycobrowser_v4 CDS 2123775 2127095 . - 0 ML1753c ML1753c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN ML1753c, len: 1106 aa. Probable transcriptional regulatory protein. Highly similar to many from Mycobacterium tuberculosis e.g. probable transcriptional regulatory protein Rv1358 TR:Q11028 (EMBL:Z75555) (1159 aa), Fasta scores: E(): 0, 58.1% identity in 1084 aa overlap. Contains a putative helix-turn-helix motif situated between residues 1063..1084 (+2.87 SD). Contains a probable helix-turn-helix motif at aa 1063-1084 (Score 1080, SD +2.87) Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00622 Bacterial regulatory proteins. Q9CBP3 No regulatory proteins PF00196 Q9CBP3 GO:0005622,GO:0007242,GO:0016849,GO:0006355,GO:0043565,GO:0003700,GO:0000156,GO:0000160,GO:0009190 Rv1358 Rv1358 AL450380.2 Mycobrowser_v4 CDS 2117017 2119182 . - 0 ML1751c moeY POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY ML1751c, len: 721 aa. Possible moeY, Molybdopterin biosynthesis protein. Similar to Mycobacterium tuberculosis SW:YD55_MYCTU (Q11025) (715 aa), Fasta scores: E(): 0, 57.3% identity in 705 aa overlap. Contains Pfam match to entry PF00899 ThiF_family, ThiF family. Q9CBP5 No intermediary metabolism and respiration PF00881,PF00899 Q9CBP5 GO:0008152,GO:0016491,GO:0005488 Rv1355c Rv1355c AL450380.2 Mycobrowser_v4 CDS 2143283 2144269 . + 0 ML1768 uspA PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPA ML1768, len: 328 aa. Probable sugar transport integral membrane protein. Similar to M. tuberculosis Rv2316 TR:P71896 (EMBL:Z79702) (290 aa), Fasta scores: E(): 0, 82.4% identity in 289 aa overlap probable sugar transport protein uspA, and to many others e.g. Thermococcus litoralis maltore transporter malF TR:O51924 (EMBL:AF012836) (300 aa), Fasta scores: E(): 4.7e-28, 33.6% identity in 283 aa overlap. Also similar to ML1426, ML1087, ML1425 and ML1088 from M. leprae. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Q9CBN8 No cell wall and cell processes PF00528 Q9CBN8 GO:0016021,GO:0005886,GO:0005351,GO:0008643 Rv2316 Rv2316 AL450380.2 Mycobrowser_v4 CDS 2145172 2146512 . + 0 ML1770 uspC PROBABLE PERIPLASMIC SUGAR-BINDING LIPOPROTEIN USPC ML1770, len: 446 aa. Probable uspC, sugar-binding lipoprotein component of sugar transport system. Similar to M. tuberculosis Rv2318 TR:P71894 (EMBL:Z79702) (440 aa), Fasta scores: E(): 0, 74.7% identity in 446 aa overlap probable sugar transport periplasmic binding protein uspC and to many others e.g. Alicyclobacillus acidocaldarius maltose binding protein precursor TR:Q9RHZ6 (EMBL:AJ252161) (427 aa), Fasta scores: E(): 3.8e-05, 22.2% identity in 347 aa overlap. Also similar to ML1427 from M. leprae. Contains probable signal sequence. Contains Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein. Q9CBN6 No cell wall and cell processes PF01547 Q9CBN6 GO:0005351,GO:0008643 Rv2318 Rv2318 AL450380.2 Mycobrowser_v4 CDS 2183202 2184326 . - 0 ML1802c ML1802c POSSIBLE EXPORTED CONSERVED PROTEIN ML1802c, len: 374 aa. Possible exported conserved protein. Similar to M. tuberculosis Rv1488 SW:YE88_MYCTU (P71768) (381 aa), Fasta scores: E(): 0, 89.8% identity in 373 aa overlap, and to many others members of the BAND 7 / MEC-2 family e.g. Streptomyces coelicolor conserved hypothetical protein SCI5.04C TR:Q9X9Z6 (EMBL:AL079332) (319 aa), Fasta scores: E(): 0, 54.7% identity in 311 aa overlap. Contains Pfam match to entry PF01145 Band_7, SPFH domain / Band 7 family. Contains PS00024 Hemopexin domain signature. Contains PS01270 Band 7 protein family signature. Q9CBM5 No cell wall and cell processes PF01145 Q9CBM5 GO:0016020 Rv1488 Rv1488 AL450380.2 Mycobrowser_v4 CDS 2322206 2323276 . - 0 ML1936c ML1936c Probable GTP binding protein ML1936c, len: 356 aa. Probable GTP binding protein. Similar to M. tuberculosis probable GTP binding protein Rv1112 TR:O53459 (EMBL:AL021897) (357 aa), Fasta scores: E(): 0, 85.9% identity in 354 aa overlap, and to many others e.g. Haemophilus influenzae probable GTP-binding protein SW:YCHF_HAEIN (P44681) (362 aa), Fasta scores: E(): 0, 53.8% identity in 355 aa overlap. Also similar to ML1465 from M. leprae. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7AQ18 No conserved hypotheticals PF01926,PF06071 Q7AQ18 GO:0005622,GO:0005525 Rv1112 Rv1112 AL450380.2 Mycobrowser_v4 CDS 2180192 2182102 . - 0 ML1800c mutA PROBABLE METHYLMALONYL-CoA MUTASE SMALL SUBUNIT MUTA (MCM) ML1800c, len: 636 aa. Probable mutA, methylmalonyl-CoA mutase small subunit. Similar to M. tuberculosis mutA Rv1492 SW:MUTA_MYCTU (P71773) (615 aa), Fasta scores: E(): 0, 75.3% identity in 636 aa overlap, and many other methylmalonyl-CoA mutase beta-subunit e.g. Streptomyces cinnamonensis SW:SW:MUTA_STRCM (Q05064) (616 aa), Fasta scores: E(): 0, 42.7% identity in 626 aa overlap. Also similar to ML1799 from M. leprae. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature. Q9CBM6 No lipid metabolism PF01642 Q9CBM6 GO:0019652,GO:0046872,GO:0004494,GO:0031419 Rv1492 Rv1492 AL450380.2 Mycobrowser_v4 CDS 2186802 2187611 . - 0 ML1806c inhA THIS ISOZYME IS INVOLVED IN MYCOLIC ACID BIOSYNTHESIS. SECOND REDUCTIVE STEP IN FATTY ACID BIOSYNTHESIS. INVOLVED IN THE RESISTANCE AGAINST THE ANTITUBERCULOSIS DRUGS ISONIAZID AND ETHIONAMIDE [CATALYTIC ACTIVITY: ACYL-[ACYL-CARRIER PROTEIN] + NAD(+) = TRANS-2,3-DEHYDROACYL-[ACYL-CARRIER PROTEIN] + NADH]. NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) ML1806c, len: 269 aa. Probable inhA, NADH-dependent enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.9). Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa), Fasta scores: E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa), Fasta scores: E(): 1.2e-17, 33.2% identity in 268 aa overlap. Also similar to ML1807 from M. leprae. Q9CBM1 No lipid metabolism 2NTV Q9CBM1 GO:0004318,GO:0006633,GO:0005488 Rv1484 Rv1484 AL450380.2 Mycobrowser_v4 CDS 2212455 2214173 . - 0 ML1828c PPE PPE-family protein ML1828c, len: 572 aa. Member of the PPE protein family. Similar to Mycobacterium tuberculosis PPE-family proteins e.g. Rv0256c or MTV034.22C TR:O53678 (EMBL:AL021929) (556 aa) fasta scores: E(): 0, 63.5% identity in 564 aa. Previously sequenced as TR:O33009 (EMBL:Z98756). Contains Pfam match to entry PF00823 PPE, PPE family. O33009 No PE/PPE PF00823 O33009 Rv0256c Rv0256c AL450380.2 Mycobrowser_v4 CDS 2226943 2228751 . - 0 ML1839c sppA POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) (SIGNAL PEPTIDE PEPTIDASE) ML1839c, len: 602 aa. Possible protease IV, signal peptide peptidase (EC 3.4.21.-). Similar to M. tuberculosis protease IV, signal peptide peptidase Rv0724, TR:P95072 (EMBL:Z84395) (623 aa), Fasta scores: E(): 0, 80.2% identity in 602 aa overlap, and to many others e.g. Escherichia coli protease IV SW:SPPA_ECOLI (P08395) (618 aa), Fasta scores: E(): 2.3e-24, 33.1% identity in 531 aa overlap. Contains 2 Pfam matches to entry PF01343 Peptidase_U7, Peptidase family U7. O33003 No cell wall and cell processes PF01343 O33003 GO:0006508,GO:0004252,GO:0006465,GO:0016021 Rv0724 Rv0724 AL450380.2 Mycobrowser_v4 CDS 2231264 2231662 . - 0 ML1845c rpsH PROBABLE 30S RIBOSOMAL PROTEIN S8 RPSH ML1845c, len: 132 aa. Probable rpsH, 30S ribosomal protein S8. Similar to M. tuberculosis 30S ribosomal protein S8 Rv0718 SW:RS8_MYCTU (P95066) (132 aa), Fasta scores: E(): 0, 93.9% identity in 132 aa overlap. Contains Pfam match to entry PF00410 Ribosomal_S8, Ribosomal protein S8. Contains PS00053 Ribosomal protein S8 signature. O32997 No information pathways PF00410 O32997 GO:0005840,GO:0003735,GO:0006412,GO:0019843 Rv0718 Rv0718 AL450380.2 Mycobrowser_v4 CDS 2240243 2240770 . - 0 ML1858c rplV PROBABLE 50S RIBOSOMAL PROTEIN L22 RPLV ML1858c, len: 175 aa. Probable rplV, 50S ribosomal protein L22. Similar to M. tuberculosis 50S ribosomal protein L22 Rv0706 SW:RL22_MYCTU (P95054) (197 aa), Fasta scores: E(): 0, 76.3% identity in 190 aa overlap. Contains Pfam match to entry PF00237 Ribosomal_L22, Ribosomal protein L22p/L17e. Contains PS00464 Ribosomal protein L22 signature. O32986 No information pathways PF00237 O32986 GO:0019843,GO:0003735,GO:0006412,GO:0015934 Rv0706 Rv0706 AL450380.2 Mycobrowser_v4 CDS 2257096 2259201 . - 0 ML1878c fusA1 PROBABLE ELONGATION FACTOR G FUSA1 (EF-G) ML1878c, len: 701 aa. Probable fusA1, elongation factor G. Similar to M. tuberculosis elongation factor G Rv0684 SW:EFG_MYCTU (O53790) (701 aa), Fasta scores: E(): 0, 90.3% identity in 701 aa overlap, and to many others e.g. Escherichia coli SW:EFG_ECOLI (P02996) (703 aa), Fasta scores: E(): 0, 59.2% identity in 703 aa overlap. Also similar to ML1498, ML0611, ML1877 and ML1556 from M. leprae. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains Pfam match to entry PF00679 EFG_C, Elongation factor G C-terminus. Contains PS00301 GTP-binding elongation factors signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). P30767 No information pathways PF00009,PF00679,PF03144,PF03764 P30767 GO:0003924,GO:0005737,GO:0003746,GO:0006414,GO:0005525 Rv0684 Rv0684 AL450380.2 Mycobrowser_v4 CDS 2280870 2281403 . - 0 ML1896c rplJ PROBABLE 50S RIBOSOMAL PROTEIN L10 RPLJ ML1896c, len: 177 aa. Probable rplJ, 50S ribosomal protein L10. Similar to M. tuberculosis 50S ribosomal protein L10 rplJ OR Rv0651 SW:RL10_MYCTU (P96940) (178 aa), Fasta scores: E(): 0, 89.3% identity in 178 aa overlap. Contains Pfam match to entry PF00466 Ribosomal_L10, Ribosomal protein L10. Q9CBK7 No information pathways PF00466 Q9CBK7 GO:0042254,GO:0003735,GO:0006412,GO:0005840 Rv0651 Rv0651 AL450380.2 Mycobrowser_v4 CDS 2287638 2288534 . + 0 ML1903 mmaA4 INVOLVED IN MYCOLIC ACIDS MODIFICATION. CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a major constituent of the mycobacterial cell wall complex. Methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; Olefinic mycolic acid methyl transferase. METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) ML1903, len: 298 aa. Probable mmaA4, methyl mycolic acid synthase (EC 2.1.1.-). Similar to M. tuberculosis methyl mycolic acid synthase 4 Rv0642c TR:P72028 (EMBL:U66108) (301 aa), Fasta scores: E(): 0, 87.5% identity in 296 aa overlap, and to many others e.g. M. tuberculosis cyclopropane-fatty-acyl-phospholipid synthase 1 SW:CFA1_MYCTU (Q11195) (287 aa), Fasta scores: E(): 0, 57.0% identity in 286 aa overlap. Also similar to ML2459, ML2426 and ML2334 from M. leprae. Q9CBK3 No lipid metabolism PF02353 Q9CBK3 GO:0008610,GO:0008825 Rv0642c Rv0642c AL450380.2 Mycobrowser_v4 CDS 2294070 2294549 . - 0 ML1910c ML1910c conserved hypothetical protein ML1910c, len: 159 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv0635 or MTCY20H10.16 TR:P96926 (EMBL:Z92772) (158 aa) fasta scores: E(): 0, 84.9% identity in 159 aa. Also similar to Streptomyces coelicolor hypothetical protein SCD82.07 TR:CAB77410 (EMBL:AL160431) (150 aa) fasta scores: E(): 1.9e-11, 30.4% identity in 148 aa. Q9CBJ6 No conserved hypotheticals, intermediary metabolism and respiration Q9CBJ6 Rv0635 Rv0635 AL450380.2 Mycobrowser_v4 CDS 2569168 2571312 . - 0 ML2161c fadB PROBABLE FATTY OXIDATION PROTEIN FADB ML2161c, len: 714 aa. Probable fadB, fatty oxidation protein. Similar to Mycobacterium tuberculosis fadB, fatty oxidationprotein Rv0860 TR:O53872 (EMBL:AL022004) fasta scores: E(): 0, 88.6% in 719 aa, and to Escherichia coli fatty oxidation complex alpha subunit SW:FADB_ECOLI (P21177) fasta scores: E(): 0, 33.0% in 684 aa. Also similar to ML1724, ML2402, ML2401, ML1241 and ML2118 from M. leprae. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Q9CBD8 No lipid metabolism PF00378,PF00725,PF02737 Q9CBD8 GO:0006631,GO:0055114,GO:0016491,GO:0050662 Rv0860 Rv0860 AL450380.2 Mycobrowser_v4 CDS 2302772 2303413 . - 0 ML1919c ML1919c CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) ML1919c, len: 213 aa. Probable carbonic anhydrase (EC 4.2.1.1). Similar to M. tuberculosis putative carbonic anhydrase Rv3588c TR:O53573 (EMBL:AL022075) (207 aa), Fasta scores: E(): 0, 84.5% identity in 207 aa overlap, and to others e.g. Chlamydomonas reinhardtii carbonic anhydrase precursor TR:Q39589 (EMBL:U41189) (267 aa), Fasta scores: E(): 7.9e-19, 34.4% identity in 192 aa overlap. Contains Pfam match to entry PF00484 Pro_CA, Prokaryotic-type carbonic anhydrases. Contains PS00704 Prokaryotic-type carbonic anhydrases signature 1. Contains PS00705 Prokaryotic-type carbonic anhydrases signature 2. Q9CBJ1 No intermediary metabolism and respiration PF00484 Q9CBJ1 GO:0004089,GO:0008270,GO:0015976 Rv3588c Rv3588c AL450380.2 Mycobrowser_v4 CDS 2310778 2311500 . - 0 ML1925c sodC PROBABLE PERIPLASMIC SUPEROXIDE DISMUTASE [CU-ZN] SODC ML1925c, len: 240 aa. Probable periplasmic superoxide dismutase precursor (EC 1.15.1.1). Similar to M. tuberculosis superoxide dismutase precursor (Cu-Zn) Rv0432 TR:P96278 (EMBL:Z84724) (240 aa), Fasta scores: E(): 0, 72.0% identity in 239 aa overlap, and weakly similar to many others e.g. Photobacterium leiognathi superoxide dismutase SW:SODC_PHOLE (P00446) (173 aa), Fasta scores: E(): 0.0018, 29.6% identity in 189 aa overlap. Contains Pfam match to entry PF00080 sodcu, Copper/zinc superoxide dismutase (SODC). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Q9CBI6 No virulence, detoxification, adaptation PF00080 Q9CBI6 GO:0005507,GO:0055114,GO:0005886,GO:0004784,GO:0006801,GO:0008270,GO:0016209 1.15.1.1 Rv0432 Rv0432 AL450380.2 Mycobrowser_v4 CDS 2327950 2329080 . + 0 ML1942 ML1942 PROBABLE CHOLESTEROL DEHYDROGENASE ML1942, len: 376 aa. Probable cholesterol dehydrogenase (EC 1.1.1.-). Similar to M. tuberculosis cholesterol dehydrogenase Rv1106c TR:O53454 (EMBL:AL021897) (370 aa), Fasta scores: E(): 0, 75.5% identity in 375 aa overlap, and to Nocardia sp NAD(P)-dependent cholesterol dehydrogenase TR:Q03704 (EMBL:D90244) (364 aa), Fasta scores: E(): 0, 71.0% identity in 366 aa overlap. Also similar to ML0204 and ML1964 from M. leprae. Contains Pfam match to entry PF01073 3Beta_HSD, 3-beta hydroxysteroid dehydrogenase/isomerase family. Q7AQ16 No intermediary metabolism and respiration PF01073 Q7AQ16 GO:0005488,GO:0006694,GO:0003854 Rv1106c Rv1106c AL450380.2 Mycobrowser_v4 CDS 2337626 2338927 . - 0 ML1951c phoH2 PROBABLE PHOH-LIKE PROTEIN PHOH2 (PHOSPHATE STARVATION-INDUCIBLE PROTEIN PSIH) ML1951c, len: 433 aa. Probable phoH2, PhoH-like protein. Similar to M. tuberculosis PhoH-like protein phoH2 Rv1095 TR:O53443 (EMBL:AL021897) (433 aa), Fasta scores: E(): 0, 92.8% identity in 432 aa overlap, and to others e.g. Escherichia coli PhoH-like protein YBEZ SW:PHOL_ECOLI (P77349) (359 aa), Fasta scores: E(): 1.1e-16, 31.2% identity in 276 aa overlap. Also similar to ML0627 from M. leprae. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9X792 No intermediary metabolism and respiration PF02562 Q9X792 GO:0005524 Rv1095 Rv1095 AL450380.2 Mycobrowser_v4 CDS 1965990 1967597 . - 0 ML1633c ML1633c Probable exported protease ML1633c, len: 535 aa. Probable exported protease (EC 3.4.-.-). Highly similar to Q10509|YM24_MYCTU Hypothetical protein Rv2224c from M. tuberculosis (520 aa), fasta scores: E(): 8.6e-188, (84.808% identity in 520 aa overlap) and Mycobacterium tuberculosis Rv2223c SW:YM23_MYCTU (Q10508) (520 aa), Fasta scores: E(): 0, 50.1% identity in 511 aa overlap. Also similar to Streptomyces lividans tripeptidylaminopeptidase precursor TR:Q54410 (EMBL:L27466) (537 aa), Fasta scores: E(): 4.3e-23, 30.7% identity in 508 aa overlap. Note this CDS is also highly similar to the adjoining CDS ML1632. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Q9CBT1 No cell wall and cell processes PF00561 Q9CBT1 GO:0016787 Rv2224c Rv2224c AL450380.2 Mycobrowser_v4 CDS 2344713 2345756 . - 0 ML1957c rpoA DNA-DEPENDENT RNA POLYMERASE CATALYZES THE TRANSCRIPTION OF DNA INTO RNA USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS SUBSTRATES. THE AMINO-TERMINAL PORTION IS INVOLVED IN THE ASSEMBLY OF CORE RNAP, WHEREAS THE C-TERMINAL IS INVOLVED IN INTERACTION WITH TRANSCRIPTIONAL REGULATORS [CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + RNA(N)]. PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE ALPHA SUBUNIT) (DNA-DIRECTED RNA NUCLEOTIDYLTRANSFERASE) ML1957c, len: 347 aa. Probable rpoA, DNA-directed RNA polymerase (alpha chain) (EC 2.7.7.6). Similar to M. tuberculosis [alpha] subunit of RNA polymerase rpoA Rv3457c SW:RPOA_MYCTU (O06324) (347 aa), Fasta scores: E(): 0, 95.7% identity in 347 aa overlap. Contains Pfam match to entry PF01000 RNA_pol_A_bac, Bacterial RNA polymerase, alpha chain. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9X798 No information pathways PF01000,PF01193,PF03118 Q9X798 GO:0003899,GO:0046983,GO:0006351,GO:0003677 2.7.7.6 Rv3457c Rv3457c AL450380.2 Mycobrowser_v4 CDS 2349343 2349951 . + 0 ML1965 rmlC INVOLVED IN dTDP-L-RHAMNOSE BIOSYNTHESIS, WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS: CONVERSION OF dTDP-4-KETO-6-DEOXY-D-GLUCOSE TO DTDP-4-KETO-RHAMNOSE [CATALYTIC ACTIVITY: dTDP-4-DEHYDRO-6-DEOXY-D-GLUCOSE = dTDP-4-DEHYDRO-6-DEOXY-L-MANNOSE]. dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE) ML1965, len: 202 aa. Probable rmlC, dTDP-4-dehydrorhamnose 3,5-epimerase. Similar to M. tuberculosis dTDP-4-dehydrorhamnose 3,5-epimerase rmlC Rv3465 TR:O06330 (EMBL:Z95390) (202 aa), Fasta scores: E(): 0, 75.4% identity in 199 aa overlap, and to many others e.g. Streptomyces griseus DTDP-4-dehydrorhamnose 3,5-epimerase SW:STRM_STRGR (P29783) (200 aa), Fasta scores: E(): 0, 45.6% identity in 193 aa overlap. Contains Pfam match to entry PF00908 dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. Q9X7A4 No intermediary metabolism and respiration PF00908 Q9X7A4 GO:0009103,GO:0008830 Rv3465 Rv3465 AL450380.2 Mycobrowser_v4 CDS 2388284 2390263 . + 0 ML1998 ML1998 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN ML1998, len: 659 aa. Probable conserved integral membrane protein. Similar to M. tuberculosis membrane protein Rv0102 SW:Y102_MYCTU (Q10897) (661 aa), Fasta scores: E(): 0, 70.2% identity in 662 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. P53525 No cell wall and cell processes PF09678 P53525 GO:0005886,GO:0016021 Rv0102 Rv0102 AL450380.2 Mycobrowser_v4 CDS 2411322 2412236 . + 0 ML2020 ML2020 conserved hypothetical protein ML2020, len: 304 aa. Conserved hypothetical protein. Similar to M. tuberculosis conserved hypothetical protein Rv1896c TR:O07736 (EMBL:Z97193) (303 aa), Fasta scores: E(): 0, 78.0% identity in 300 aa overlap, and to many other M. tuberculosis hypothetical proteins e.g. Rv3399 SW:YX99_MYCTU (Z77165) (348 aa), Fasta scores: E(): 0, 41.4% identity in 304 aa overlap. Also similar to ML2640 and ML2539 from M. leprae. Q9CBG0 No conserved hypotheticals PF02409 Q9CBG0 GO:0008168 2.1.1.- Rv1896c Rv1896c AL450380.2 Mycobrowser_v4 CDS 2441104 2442111 . - 0 ML2053c adhA Probable alcohol dehydrogenase AdhA ML2053c, len: 335 aa. Probable adhA, alcohol dehydrogenase (EC 1.1.1.1). Similar to Mycobacterium tuberculosis adhA or Rv1862 or MTCY359.11 TR:P95153 (EMBL:Z83859) (346 aa) fasta scores: E(): 0, 84.5% identity in 336 aa. Similar to Rhizobium meliloti alcohol dehydrogenase adhA SW:ADHA_RHIME (O31186) (340 aa) fasta scores: E(): 6.3e-26, 33.1% identity in 344 aa and many putative alcohol dehydrogenases. Also similar to ML1730, ML1784 and ML2025 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Q9CBF1 No intermediary metabolism and respiration PF00107,PF08240 Q9CBF1 GO:0016491,GO:0008270,GO:0055114 Rv1862 Rv1862 AL450380.2 Mycobrowser_v4 CDS 2448429 2449829 . + 0 ML2061 ndh PROBABLE NADH DEHYDROGENASE NDH ML2061, len: 466 aa. Probable ndh, NADH dehydrogenase (EC 1.6.99.3). Similar to Mycobacterium tuberculosis hypothetical 49.6 kda protein TR:P95160 (EMBL:Z83859) fasta scores: E(): 0, 90.2% in 460 aa, and to Corynebacterium glutamicum NADH dehydrogenase TR:Q9X710 (EMBL:AJ238250) fasta scores: E(): 0, 56.5% in 455 aa. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Q7APZ9 No intermediary metabolism and respiration PF00070,PF07992 Q7APZ9 GO:0016491,GO:0050660 Rv1854c Rv1854c AL450380.2 Mycobrowser_v4 CDS 2458003 2460198 . + 0 ML2069 glcB PROBABLE MALATE SYNTHASE G GLCB ML2069, len: 731 aa. Probable glcB, malate synthase G (EC 4.1.3.2). Similar to Mycobacterium tuberculosis probable malate synthase g SW:MASZ_MYCTU (Q50596) fasta scores: E(): 0, 82.4% in 729 aa, and to Escherichia coli malate synthase g SW:MASZ_ECOLI () fasta scores: E(): 0, 56.9% in 731 aa. O32913 No intermediary metabolism and respiration PF01274 O32913 GO:0006097,GO:0004474,GO:0006099,GO:0005737 2.3.3.9 Rv1837c Rv1837c AL450380.2 Mycobrowser_v4 CDS 2481551 2482855 . - 0 ML2088c ML2088c putative cytochrome p450 ML2088c, len: 434 aa. Putative cytochrome p450. Similar to several e.g. Q9X8Q3|AL049754 Streptomyces coelicolor putative cytochrome p-450 hydroxylase (411 aa), fasta scores: E(): 0, (37.4% in 401 aa), and to Rv1880c|YI80_MYCTU|O08464 Mycobacterium tuberculosis putative cytochrome p450 (438 aa), fasta scores: E(): 0, (38.0% in 416 aa). And to BIOI_BACSU|P53554 Bacillus subtilis biotin biosynthesis; cytochrome p450-like enzyme (395 aa), fasta scores: E(): 0, (37.1% in 383 aa). Contains Pfam match to entry PF00067 p450, Cytochrome P450. BELONGS TO THE CYTOCHROME P450 FAMILY. Q9CBE7 No intermediary metabolism and respiration PF00067 Q9CBE7 GO:0020037,GO:0005506,GO:0004497,GO:0055114,GO:0009055 AL450380.2 Mycobrowser_v4 CDS 2559343 2560992 . + 0 ML2157 ercC3 PROBABLE DNA HELICASE ERCC3 ML2157, len: 549 aa. Probable ercC3, DNA helicase (EC 3.6.1.-). Similar to Mycobacterium tuberculosis putative DNA helicase Rv0861c|TR:O53873 (EMBL:AL022004) fasta scores: E(): 0, 91.1% in 542 aa, and to Saccharomyces cerevisiae DNA repair helicase RAD25 SW:RA25_YEAST (Q00578) fasta scores: E(): 0, 29.3% in 611 aa. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Q9CBE0 No information pathways PF00271,PF04851 Q9CBE0 GO:0004003,GO:0003677,GO:0006289,GO:0005524 Rv0861c Rv0861c AL450380.2 Mycobrowser_v4 CDS 2472094 2472714 . - 0 ML2081c pgsA2 THOUGHT TO BE INVOLVED IN CARDIOLIPIN BIOSYNTHESIS; GENERATES CARDIOLIPIN FROM PHOSPHATIDYLGLYCEROL AND CDP-DIACYLGLYCEROL [CATALYTIC ACTIVITY : MAY BE: PHOSPHATIDYLGLYCEROL + PHOSPHATIDYLGLYCEROL -> CARDIOLIPIN + GLYCEROL, OR: CDP-DIACYLGLYCEROL + GLYCEROL 3-PHOSPHATE = CMP + 3-(3-PHOSPHATIDYL)-GLYCEROL 1-PHOSPHATE]. PROBABLECDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE) ML2081c, len: 206 aa. Probable pgsA2, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase (EC 2.7.8.5). Similar to Mycobacterium tuberculosis putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl- transferase SW:PGSA_MYCTU (Q50611) fasta scores: E(): 0, 76.6% in 205 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SW:PGSA_ECOLI (P06978) fasta scores: E(): 4.5e-11, 30.5% in 177 aa. Also similar to ML0979 from M. leprae. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. O32921 No lipid metabolism PF01066 O32921 GO:0016021,GO:0008654,GO:0008444 Rv1822 Rv1822 AL450380.2 Mycobrowser_v4 CDS 2490070 2491029 . - 0 ML2094c pstC2 PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTC2 ML2094c, len: 319 aa. Probable pstC2, phosphate-transport integral membrane ABC transporter. Similar to Mycobacterium tuberculosis phosphate transport system integral membrane ABC transporter pstc2 Rv0929 TR:O86344 (EMBL:Z47983) fasta scores: E(): 0, 83.0% in 317 aa, and to Escherichia coli phosphate transport system permease protein pstc SW:PSTC_ECOLI (P07653) fasta scores: E(): 1.7e-30, 33.9% in 304 aa. Also similar to ML2191c a possible pseudogene similar to M. tuberculosis pstC2. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Q50098 No cell wall and cell processes PF00528 Q50098 GO:0016021,GO:0006817,GO:0005886,GO:0005315 Rv0929 Rv0929 AL450380.2 Mycobrowser_v4 CDS 2531621 2532916 . - 0 ML2130c gltA2 PROBABLE CITRATE SYNTHASE I GLTA2 ML2130c, len: 431 aa. Probable gltA2, citrate synthase 1 (EC 4.1.3.7). Similar to Mycobacterium tuberculosis citrate synthase 1 Rv0896 SW:CISY_MYCTU (Q10530) fasta scores: E(): 0, 91.0% in 431 aa, and to Corynebacterium glutamicum citrate synthase SW:CISY_CORGL (P42457) fasta scores: E(): 0, 62.7% in 432 aa. Contains Pfam match to entry PF00285 citrate_synt, Citrate synthase. Contains PS00480 Citrate synthase signature. O33066 No intermediary metabolism and respiration PF00285 O33066 GO:0004108,GO:0005737,GO:0044262 2.3.3.1 Rv0896 Rv0896 AL450380.2 Mycobrowser_v4 CDS 2524876 2526216 . + 0 ML2124 prrB TWO COMPONENT SENSOR HISTIDINE KINASE PRRB ML2124, len: 446 aa. Probable prrB, two component sensor histidine kinase (EC 2.7.3.-). Similar to Mycobacterium tuberculosis probable sensor-like histidine kinase Rv0902c SW:Y902_MYCTU (Q10560) fasta scores: E(): 0, 92.4% in 446 aa, and to Escherichia coli sensor protein cpxa SW:CPXA_ECOLI (P08336) fasta scores: E(): 7e-14, 28.9% in 301 aa. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains Pfam match to entry PF00512 signal, Histidine kinase. O33071 No regulatory proteins PF00512,PF00672,PF02518 O33071 GO:0016021,GO:0018106,GO:0005886,GO:0000155,GO:0000160,GO:0005524 2.7.13.3 Rv0902c Rv0902c AL450380.2 Mycobrowser_v4 CDS 3102980 3103534 . + 0 ML2598 ML2598 PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN ML2598, len: 184 aa. Probable conserved Mce associated membrane protein. Similar to Mycobacterium tuberculosis MCE associated membrane protein Rv0178 TR:O07422 (EMBL:Z97050) fasta scores: E(): 0, 65.6% identity in 244 aa. Contains a possible N-terminal signal sequence. Q9CD05 No cell wall and cell processes Q9CD05 Rv0178 Rv0178 AL450380.2 Mycobrowser_v4 CDS 2588604 2589557 . - 0 ML2177c ML2177c Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {Catalytic activity: Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate]. probable uridine phosphorylase ML2177c, len: 317 aa. Probable uridine phosphorylase (EC 2.4.2.3), similar to P52624|UDP1_MOUSE Mus musculus uridine phosphorylase (311 aa), fasta scores: E(): 1.9e-21, (34.0% in 268 aa), and to Q16831|UDP1_HUMAN Homo sapiens uridine phosphorylase (310 aa), fasta scores: E(): 2.2e-19, (32.4% in 275 aa). Contains PS01232 Purine and other phosphorylases family 1 signature. Q9CBD1 No intermediary metabolism and respiration PF01048 Q9CBD1 GO:0009116,GO:0009166,GO:0004850,GO:0005737 AL450380.2 Mycobrowser_v4 CDS 2606838 2608127 . - 0 ML2192c pstS4 Probable phosphate-binding protein 4 precursor PstS4 ML2192c, len: 429 aa. Probable pstS4, phosphate-binding protein 4 precursor, similar to several mycobacterial phosphate-binding proteins e.g. Q9KK89|PST3_MYCAV Phosphate-binding protein 3 precursor (369 aa), fasta scores: E(): 6.9e-63, (47.011% identity in 368 aa overlap) and Rv0928|O86343|PST3_MYCTU Phosphate-binding protein 3 precursor (370 aa), fasta score: E(): 1.3e-62, (46.505% identity in 372 aa overlap), and to PSTS_ECOLI|P06128|P76744 Escherichia coli phosphate-binding periplasmic protein precursor (346 aa), fasta scores: E(): 1.3e-20, (27.9% in 344 aa). Also similar to ML2095|Q9CBE5|PST3_MYCLE from M. leprae. Contains Pfam match to entry PF01449 PstS, Phosphate-binding protein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note M. tuberculosis does not have pstS3 at this location Q50043 No cell wall and cell processes PF01547 Q50043 GO:0006817,GO:0005315 AL450380.2 Mycobrowser_v4 CDS 2619428 2620522 . - 0 ML2205c purM PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) ML2205c, len: 364 aa. Probable purM, 5'-phosphoribosyl-5-aminoimidazole synthetase (EC 6.3.3.1). Similar to Mycobacterium tuberculosis 5'-phosphoribosyl-5-aminoimidazole synthetase Rv0809 TR:O53823 (EMBL:AL022004) fasta scores: E(): 0, 87.1% identity in 364 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine cyclo-ligase PURM SW:PUR5_BACSU (P12043) fasta scores: E(): 0, 46.4% identity in 334 aa. Contains Pfam match to entry PF00586 AIRS, AIR synthase related protein. Q9CBC2 No intermediary metabolism and respiration PF00586,PF02769 Q9CBC2 GO:0005737,GO:0004641,GO:0006189 6.3.3.1 Rv0809 Rv0809 AL450380.2 Mycobrowser_v4 CDS 2626960 2629224 . - 0 ML2211c purL PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) ML2211c, len: 754 aa. purL, phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3). Similar to Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PURL OR Rv0803 OR MTCY07H7A.06C SW:PURL_MYCTU (P54876; O06631) fasta scores: E(): 0, 90.3% identity in 754 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine synthase ii PURL SW:PURL_BACSU (P12042) fasta scores: E(): 0, 43.0% identity in 739 aa. Contains 2 Pfam matches to entry PF00586 AIRS, AIR synthase related protein. Q50023 No intermediary metabolism and respiration PF00586,PF02769 Q50023 GO:0005524,GO:0005737,GO:0004642,GO:0006189 6.3.5.3 Rv0803 Rv0803 AL450380.2 Mycobrowser_v4 CDS 2698914 2700140 . - 0 ML2276c ML2276c possibleputative FAD-linked oxidoreductase ML2276c, len: 408 aa. Possible FAD-linked oxidoreductase. Similar to Mycobacterium tuberculosis putative oxidoreductase Rv0561c or MTCY25D10.40C TR:O06427 (EMBL:Z95558) (408 aa) fasta scores: E(): 0, 84.5% identity in 406 aa. Shows weak similarity to many oxidoreductases e.g. Escherichia coli FixC protein fixC SW:FIXC_ECOLI (P31575; P75626) (428 aa) fasta scores: E(): 1.7e-05, 25.4% identity in 417 aa. Contains Pfam match to entry PF01494 FAD_binding_3, FAD binding domain. Q9CBA6 No intermediary metabolism and respiration PF01266,PF07992 Q9CBA6 GO:0016491,GO:0008152 Rv0561c Rv0561c AL450380.2 Mycobrowser_v4 CDS 2645038 2645931 . - 0 ML2227c purC PHOSPHORIBOSYLAMINOIMIDAZOLE- SUCCINOCARBOXAMIDE SYNTHASE PURC (SAICAR SYNTHETASE) ML2227c, len: 297 aa. purC, phosphoribosylaminoimidazole-succinocarboxamid synthase (EC 6.3.2.6). Similar to Mycobacterium tuberculosis phosphoribosylaminoimidazole-succinocarboxamide synthase PURC OR Rv0780 OR MTCY369.24 SW:PUR7_MYCTU (Q59566; P77904) fasta scores: E(): 0, 81.5% identity in 297 aa, and to Haemophilus influenzae putative phosphoribosylaminoimidazole-succinocarboxamide synthase PURC OR HI1726 SW:PUR7_HAEIN (P43851) fasta scores: E(): 0, 46.0% identity in 287 aa, and to Candida maltosa phosphoribosylamidoimidazole-succinocarboxamide synthase ADE1 SW:PUR7_CANMA (P27602) fasta scores: E(): 0, 45.1% identity in 288 aa. Contains Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase. Contains PS01057 SAICAR synthetase signature 1. Contains PS01058 SAICAR synthetase signature 2. O08361 No intermediary metabolism and respiration PF01259 O08361 GO:0004639,GO:0006164,GO:0005524 6.3.2.6 Rv0780 Rv0780 AL450380.2 Mycobrowser_v4 CDS 2684496 2684912 . - 0 ML2261c ML2261c conserved hypothetical protein ML2261c, len: 138 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0546c OR MTCY25D10.25C TR:O06412 (EMBL:Z95558) fasta scores: E(): 0, 84.7% identity in 131 aa. Also some similarity to Haemophilus influenzae lactoylglutathione lyase GLOA OR HI0323 SW:LGUL_HAEIN (P44638) fasta scores: E(): 0.084, 29.1% identity in 127 aa. Q9CBB6 No conserved hypotheticals PF00903 Q9CBB6 Rv0546c Rv0546c AL450380.2 Mycobrowser_v4 CDS 2697290 2698006 . + 0 ML2273 menH PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase) ML2273, len: 238 aa. Probable menH, ubiquinone/menaquinone biosynthesis methyltransferase (EC 2.1.1.-). Similar to Mycobacterium tuberculosis putative ubiquinone/menaquinone biosynthesis methyltransferase Rv0558 or MTCY25D10.37 TR:O06424 (EMBL:Z95558) (234 aa) fasta scores: E(): 0, 83.3% identity in 228 aa. Similar to many e.g. Streptomyces coelicolor putative ubiquinone/menaquinone methyltransferase SC10A7.27C TR:Q9XAP8 (EMBL:AL078618) (231 aa) fasta scores: E(): 0, 64.9% identity in 225 aa and to Escherichia coli ubiquinone/menaquinone biosynthesis methyltransferase UbiE ubiE SW:UBIE_ECOLI (P27851) (251 aa) fasta scores: E(): 2.7e-19, 42.8% identity in 229 aa. Contains Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family. Q9CBA8 No intermediary metabolism and respiration PF01209 Q9CBA8 GO:0008168,GO:0009234 2.1.1.- Rv0558 Rv0558 AL450380.2 Mycobrowser_v4 CDS 3104669 3106066 . - 0 ML2600c ML2600c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2600c, len: 465 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 47.6 kda protein Rv0180c TR:O07424 (EMBL:Z97050) fasta scores: E(): 0, 76.7% identity in 447 aa. Contains multiple possible membrane spanning hydrophobic domains. Q9CD04 No cell wall and cell processes Q9CD04 Rv0180c Rv0180c AL450380.2 Mycobrowser_v4 CDS 3080183 3081337 . - 0 ML2580c ML2580c PROBABLE INTEGRAL MEMBRANE ACYLTRANSFERASE ML2580c, len: 384 aa. Probable integral membrane acyltransferase (EC 2.3.1.-). Similar to Mycobacterium tuberculosis integral membrane acyltransferase Rv0228 TR:P96410 (EMBL:Z92669) fasta scores: E(): 0, 79.5% identity in 381 aa, and to Streptomyces mycarofaciens acyltransferase involved in midecamycin biosynthesis SW:MDMB_STRMY (Q00718) fasta scores: E(): 1.3e-13, 28.8% identity in 400 aa. Also similar to ML1101 from M. leprae. Q7APT8 No intermediary metabolism and respiration PF01757 Q7APT8 GO:0008415 Rv0228 Rv0228 AL450380.2 Mycobrowser_v4 CDS 2702665 2704155 . - 0 ML2279c ML2279c Probable transmembrane transport protein ML2279c, len: 496 aa. Probable transmembrane transport protein. Similar to the N-terminal part of Mycobacterium tuberculosis transmembrane carbonic anhydrase Rv3273 or MTCY71.13 TR:P96878 (EMBL:Z92771) (764 aa) fasta scores: E(): 0, 59.4% identity in 483 aa. Similar to many putative membrane proteins e.g. Streptomyces coelicolor putative integral membrane protein sch5.25 TR:Q9X927 (EMBL:AL035636) (830 aa) fasta scores: E(): 0, 46.5% identity in 475 aa. Contains Pfam match to entry PF00916 Sulfate_transp, Sulfate transporter family. Q9CBA3 No cell wall and cell processes, intermediary metabolism and respiration PF00916 Q9CBA3 GO:0006810,GO:0005215,GO:0016021 Rv3273 Rv3273 AL450380.2 Mycobrowser_v4 CDS 2730220 2731365 . + 0 ML2306 ML2306 PROBABLE ANION TRANSPORTER ATPASE ML2306, len: 381 aa. Probable anion transporter ATPase. Similar to Mycobacterium tuberculosis putative anion transporting ATPase Rv3680 TR:O69648 (EMBL:AL022121) (386 aa) fasta scores: E(): 0, 88.1% identity in 370 aa, and to Streptomyces coelicolor putative ion-transporting ATPase TR:Q9XA35 (EMBL:AL079353) (481 aa) fasta scores: E(): 0, 48.6% identity in 432 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CB87 No cell wall and cell processes PF02374 Q9CB87 GO:0006875,GO:0005524 Rv3680 Rv3680 AL450380.2 Mycobrowser_v4 CDS 2725730 2726491 . - 0 ML2301c nth HAS BOTH AN APURINIC AND/OR APYRIMIDINIC ENDONUCLEASE ACTIVITY AND A DNA N-GLYCOSYLASE ACTIVITY. INCISES DAMAGED DNA AT CYTOSINES, THYMINES AND GUANINES. ACTS ON A DAMAGED STRAND (OXIDIZED PYRIMIDINES), 5' FROM THE DAMAGED SITE [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE NEAR APURINIC OR APYRIMIDINIC SITES TO PRODUCTS WITH 5'-PHOSPHATE]. PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC SITE)LYASE) (AP LYASE) (AP ENDONUCLEASE CLASS I) (ENDODEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) (DEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) ML2301c, len: 253 aa. Probable nth, endonuclease III. Similar to Mycobacterium tuberculosis endonuclease III ntH or Rv3674c or MTV025.022C SW:END3_MYCTU (O69642) (245 aa) fasta scores: E(): 0, 89.4% identity in 226 aa. Similar to many e.g. Micrococcus luteus ultraviolet N-glycosylase/ap lyase pdG SW:UVEN_MICLU (P46303) (279 aa) fasta scores: E(): 0, 57.7% identity in 246 aa and to Escherichia coli endonuclease III ntH SW:END3_ECOLI (P20625) (211 aa) fasta scores: E(): 7.6e-24, 36.6% identity in 205 aa. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III. Contains PS01155 Endonuclease III family signature. Contains PS00764 Endonuclease III iron-sulfur binding region signature. Q9CB92 No information pathways PF00730,PF10576 Q9CB92 GO:0003906,GO:0006284,GO:0004519,GO:0016798,GO:0005622,GO:0005506,GO:0051539 4.2.99.18 Rv3674c Rv3674c AL450380.2 Mycobrowser_v4 CDS 2884711 2886051 . - 0 ML2414c hemL PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) ML2414c, len: 446 aa. Probable hemL, glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8). Similar to Mycobacterium tuberculosis glutamate-1-semialdehyde 2,1-aminomutase HemL Rv0524 SW:GSA_MYCTU (O06390) (462 aa) fasta scores: E(): 0, 82.4% identity in 460 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL SW:GSA_ECOLI (P23893; P78277) (426 aa) fasta scores: E(): 0, 53.0% id in 419 aa. Also similar to ML1409 from M. leprae. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. P46716 No intermediary metabolism and respiration PF00202 P46716 GO:0042286,GO:0006779,GO:0030170,GO:0008483,GO:0005737 5.4.3.8 Rv0524 Rv0524 AL450380.2 Mycobrowser_v4 CDS 2277267 2278283 . - 0 ML1892c mkl POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL ML1892c, len: 338 aa. Possible mkl, ribonucleotide-transport ATP-binding protein ABC transporter. Similar to M. tuberculosis ABC transporter Rv0655 SW:MKL_MYCTU (O06784) (359 aa), Fasta scores: E(): 0, 93.2% identity in 336 aa overlap, and to many others e.g. Escherichia coli hypothetical ABC transporter ATP-binding protein SW:YRBF_ECOLI (P45393) (269 aa), Fasta scores: E(): 2.4e-32, 38.9% identity in 252 aa overlap. Also similar to ML0669, ML1424, ML1089, ML2352, ML2189, ML0336, ML1122, ML1113, ML0595, ML1114, ML0590, ML1726 and ML1816 from M. leprae. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. P30769 No cell wall and cell processes PF00005 P30769 GO:0016887,GO:0006810,GO:0005524 Rv0655 Rv0655 AL450380.2 Mycobrowser_v4 CDS 2754647 2756470 . + 0 ML2324 leuA INVOLVED IN LEUCINE BIOSYNTHESIS (AT THE FIRST STEP). CATALYZES CONDENSATION OF ACETYL-CoA AND 2-OXOISOVALERATE TO FORM 2-ISOPROPYLMALATE SYNTHASE [CATALYTIC ACTIVITY: 3-CARBOXY-3-HYDROXY-4-METHYLPENTANOATE + CoA = ACETYL-COA + 3-METHYL-2-OXOBUTANOATE + H(2)O]. 2-ISOPROPYLMALATE SYNTHASE LEUA (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) ML2324, len: 607 aa. leu, 2-isopropylmalate synthase (EC 4.1.3.12). Similar to Mycobacterium tuberculosis 2-isopropylmalate synthase leuA or Rv3710 SW:LEU1_MYCTU (P96420; O69677) (644 aa) fasta scores: E(): 0, 80.7% identity in 642 aa, and to Corynebacterium glutamicum 2-isopropylmalate synthase leuA SW:LEU1_CORGL (P42455) (616 aa) fasta scores: E(): 0, 66.8% identity in 602 aa. Contains Pfam match to entry PF00682 HMGL-like, HMGL-like. Contains PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. Contains PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. Q9CB76 No intermediary metabolism and respiration PF00682,PF08502 Q9CB76 GO:0009098,GO:0003852 2.3.3.13 Rv3710 Rv3710 AL450380.2 Mycobrowser_v4 CDS 2767659 2768939 . - 0 ML2336c ML2336c conserved hypothetical protein ML2336c, len: 426 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical 44.4 kDa protein Rv3722c TR:O69689 (EMBL:AL022121) (435 aa) fasta scores: E(): 0, 87.6% identity in 396 aa, and to Deinococcus radiodurans conserved hypothetical protein TR:Q9RU17 (EMBL:AE002001) (452 aa) fasta scores: E(): 0, 43.1% identity in 450 aa. Note start changed since first submission. Q9CB73 No conserved hypotheticals Q9CB73 GO:0030170,GO:0003824 Rv3722c Rv3722c AL450380.2 Mycobrowser_v4 CDS 2779484 2781682 . - 0 ML2341c ML2341c possible transcriptional regulatory protein ML2341c, len: 732 aa. Possible transcriptional regulatory protein. The N-terminus of the predicted product of this CDS is similar to many adenylate cyclases e.g. Stigmatella aurantiaca adenylate cyclase 2 CyaB SW:CYAB_STIAU (P40138; O54080) (352 aa) fasta scores: E(): 3.8e-07, 35.9% identity in 192 aa. The C-terminus is similar to many proteins of undefined function and to several proposed regulatory proteins e.g. Streptomyces coelicolor putative regulatory protein TR:Q9Z573 (EMBL:AL035569) (194 aa), BlastP Expect 6.1. Contains Pfam match to entry PF00211 guanylate_cyc, Adenylate and Guanylate cyclase catalytic domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CB72 No regulatory proteins PF00211 Q9CB72 GO:0007242,GO:0017111,GO:0000166,GO:0016849,GO:0009190 AL450380.2 Mycobrowser_v4 CDS 2816101 2821716 . - 0 ML2357c ppsA PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA ML2357c, len: 1871 aa. Probable ppsA, type-I polyketide synthase. Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% identity in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% identity in 1823 aa. Also similar to ML2353, ML2354, ML0139, ML0135, ML2354, ML2355, ML2356, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. Q7APV8 No lipid metabolism PF00109,PF00550,PF00698,PF02801,PF08659 Q7APV8 GO:0009058,GO:0048037,GO:0031177,GO:0016740,GO:0000036 Rv2931 Rv2931 AL450380.2 Mycobrowser_v4 CDS 2305502 2306866 . + 0 ML1923 lpqF PROBABLE CONSERVED LIPOPROTEIN LPQF ML1923, len: 454 aa. Probable lpqF, conserved lipoproteins. Similar to M. tuberculosis lipoprotein Rv3593 lpqF TR:O06155 (EMBL:Z95555) (452 aa), Fasta scores: E(): 0, 79.2% identity in 451 aa overlap, and weakly to several beta-lactamase proteins e.g. Xanthomonas maltophilia chromosomic class A beta-lactamase TR:Q9X5A7 (EMBL:AF123246) (304 aa), Fasta scores: E(): 0.019, 26.2% identity in 260 aa overlap. Q9CBI7 No cell wall and cell processes Q9CBI7 Rv3593 Rv3593 AL450380.2 Mycobrowser_v4 CDS 2804876 2811481 . - 0 ML2355c ppsC PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC ML2355c, len: 2201 aa. ppsC, type-I polyketide synthase. Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% identity in 2217 aa. Also similar to ML2353, ML2354, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101 from M. leprae. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl synthases active site. Q49933 No lipid metabolism PF00107,PF00109,PF00550,PF00698,PF02801,PF08240,PF08659 Q49933 GO:0009058,GO:0048037,GO:0055114,GO:0016491,GO:0031177,GO:0016740,GO:0008270,GO:0000036 Rv2933 Rv2933 AL450380.2 Mycobrowser_v4 CDS 2863244 2863738 . + 0 ML2393 greA NECESSARY FOR EFFICIENT RNA POLYMERASE TRANSCRIPTION ELONGATION PAST TEMPLATE-ENCODED ARRESTING SITES. THE ARRESTING SITES IN DNA HAVE THE PROPERTY OF TRAPPING A CERTAIN FRACTION OF ELONGATING RNA POLYMERASES THAT PASS THROUGH, RESULTING IN LOCKED TERNARY COMPLEXES. CLEAVAGE OF THE NASCENT TRANCRIPT BY CLEAVAGE FACTORS SUCH AS GREA OR GREB ALLOWS THE RESUMPTION OF ELONGATION FROM THE NEW 3'TERMINUS. GREA RELEASES SEQUENCES OF 2 TO 3 NUCLEOTIDES PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA (Transcript cleavage factor greA) ML2393, len: 164 aa. Probable greA, transcription elongation factor G. Similar to Mycobacterium tuberculosis transcription elongation factor Rv1080c SW:GREA_MYCTU (O53428) (164 aa) fasta scores: E(): 0, 94.5% identity in 164 aa, and to Escherichia coli transcription elongation factor GreA SW:GREA_ECOLI (P21346; P78111) (158 aa) fasta scores: E(): 1e-08, 34.6% identity in 159 aa. Contains Pfam match to entry PF01272 GreA_GreB, Prokaryotic transcription elongation factor, GreA/GreB. Contains PS00829 Prokaryotic transcription elongation factors signature 1. Contains PS00830 Prokaryotic transcription elongation factors signature 2. P46808 No information pathways PF01272,PF03449 P46808 GO:0006355,GO:0006350,GO:0003711,GO:0003677 Rv1080c Rv1080c AL450380.2 Mycobrowser_v4 CDS 2038222 2039808 . - 0 ML1692c serA1 PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) ML1692c, len: 528 aa. Probable serA1, D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95). Highly similar to many D-3-phosphoglycerate dehydrogenases involved in serine biosynthesis including: Bacillus subtilis SW:SERA_BACSU (P35136) (525 aa), Fasta scores: E(): 0, 36.1% identity in 527 aa overlap and Mycobacterium tuberculosis Rv2996c SW:SERA_MYCTU (O53243) (528 aa), Fasta scores: E(): 0, 89.6% identity in 528 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. Contains PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. O33116 No intermediary metabolism and respiration PF00389,PF01842,PF02826 O33116 GO:0051287,GO:0016597,GO:0055114,GO:0004617,GO:0006564 1.1.1.95 Rv2996c Rv2996c AL450380.2 Mycobrowser_v4 CDS 2144256 2145080 . + 0 ML1769 uspB PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPB ML1769, len: 274 aa. Probable uspB, sugar-transport integral membrane protein ABC transporter. Similar to M. tuberculosis Rv2317 TR:P71895 (EMBL:Z79702) uspB, sugar-transport integral membrane protein ABC transporter (274 aa), Fasta scores: E(): 0, 85.0% identity in 274 aa overlap, and to many others e.g. Thermomonospora fusca cellobiose transport permease bglB TR:AAF37729 (EMBL:AF086819) (305 aa), Fasta scores: E(): 1.9e-24, 30.2% identity in 275 aa overlap. Also similar to ML1425 and ML1088 from M. leprae. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Note previously known as uspE. Q9CBN7 No cell wall and cell processes PF00528 Q9CBN7 GO:0016021,GO:0005886,GO:0005351,GO:0008643 Rv2317 Rv2317 AL450380.2 Mycobrowser_v4 CDS 2612068 2612901 . + 0 ML2198 cysA2 PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) ML2198, len: 277 aa. Probable cysA2, thiosulfate sulfurtransferase (EC 2.8.1.1). Similar to several e.g. Mycobacterium tuberculosis putative thiosulfate sulfurtransferase SW:THTR_MYCTU (O05793) Rv0815c and Rv3117 fasta scores: E(): 0, 85.2% in 277 aa, and to Saccharopolyspora erythraea putative thiosulfate sulfurtransferase SW:THTR_SACER (P16385) fasta scores: E(): 0, 74.1% in 274 aa, and to Corynebacterium glutamicum thiosulfate sulfurtransferase SW:THTR_CORGL (P71121) fasta scores: E(): 0, 44.5% in 218 aa. Also similar to ML0728 from M. leprae. Contains 2 Pfam matches to entry PF00581 Rhodanese, Rhodanese-like domain. Contains PS00683 Rhodanese C-terminal signature. Q50036 No intermediary metabolism and respiration PF00581 Q50036 GO:0004792,GO:0008272 2.8.1.1 Rv0815c Rv0815c AL450380.2 Mycobrowser_v4 CDS 2369809 2372205 . - 0 ML1985c aceA PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) ML1985c, len: 798 aa. Probable aceA, isocitrate lyase (EC 4.1.3.1). Previously sequenced as Mycobacterium leprae isocitrate lyase SW:ACEA_MYCLE (P46831) (606 aa), Fasta scores: E(): 0, 99.8% identity in 568 aa overlap. Similar to M. tuberculosis isocitrate lyase N-terminal and C-terminal modules aceAa Rv1915 TR:O07718 (EMBL:Z97193) (367 aa), Fasta scores: E(): 0, 87.1% identity in 295 aa overlap and aceAb Rv1916 TR:O07717 (EMBL:Z97193) (398 aa), Fasta scores: E(): 0, 87.9% identity in 397 aa overlap, and to many others e.g. Coprinus cinereus isocitrate lyase SW:ACEA_COPCI (O13439) (537 aa), Fasta scores: E(): 0, 38.1% identity in 586 aa overlap. Contains 2 Pfam matches to entry PF00463 ICL, Isocitrate lyase. Contains PS00161 Isocitrate lyase signature. P46831 No intermediary metabolism and respiration PF00463 P46831 GO:0006097,GO:0004451,GO:0006099,GO:0005737 4.1.3.1 Rv1916 Rv1916 AL450380.2 Mycobrowser_v4 CDS 1997451 1998872 . + 0 ML1657 accD6 ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 ML1657, len: 473 aa. Probable accD6, acetyl/propionyl CoA carboxylase [beta] subunit (EC 6.4.1.3). Highly similar to many propionyl-CoA carboxylases involved in fatty acid catabolism including: Rhodococcus erythropolis SW:PCCB_RHOER (Q06101) (476 aa), Fasta scores: E(): 0, 70.9% identity in 477 aa overlap and Mycobacterium tuberculosis Rv2247 SW:PCCB_MYCTU (Q10506) (473 aa), Fasta scores: E(): 0, 92.8% identity in 473 aa overlap. Also similar to ML0731 from M. leprae. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7AQ32 No lipid metabolism PF01039 Q7AQ32 GO:0016874 Rv2247 Rv2247 AL450380.2 Mycobrowser_v4 CDS 1989171 1991981 . + 0 ML1651 aceE Probable pyruvate dehydrogenase E1 component aceE (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC DEHYDROGENASE) ML1651, len: 936 aa. Probable aceE, pyruvate dehydrogenase E1 component (EC 1.2.4.1). Highly similar to many pyruvate dehydrogenases including: Escherichia coli pyruvate dehydrogenase E1 component SW:ODP1_ECOLI (P06958) (886 aa), Fasta scores: E(): 0, 51.3% identity in 892 aa overlap and Mycobacterium tuberculosis Rv2241 SW:ODP1_MYCTU (Q10504) (901 aa), Fasta scores: E(): 0, 89.5% identity in 904 aa overlap. Q9CBS8 No intermediary metabolism and respiration Q9CBS8 GO:0016491,GO:0008152 Rv2241 Rv2241 AL450380.2 Mycobrowser_v4 CDS 2693812 2695482 . + 0 ML2270 menD INVOLVED IN MENAQUINONE BIOSYNTHESIS (AT THE FIRST STEP) [CATALYTIC ACTIVITY 1: ISOCHORISMATE + 2-KETOGLUTARATE = 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE + PYRUVATE + CO(2)] [CATALYTIC ACTIVITY 2: 2-OXOGLUTARATE = SUCCINATE SEMIALDEHYDE + CO(2)]. PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA- KETOGLUTARATE DECARBOXYLASE) (KDC) ML2270, len: 556 aa. Probable menD, menaquinone biosynthesis protein, including 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.1.3.-) and 2-oxoglutarate decarboxylase (EC 4.1.1.71) activities. Similar to Mycobacterium tuberculosis menD or Rv0555 or MTCY25D10.34 TR:O06421 (EMBL:Z95558) (554 aa) fasta scores: E(): 0, 85.4% identity in 556 aa. Similar to Bacillus subtilis menaquinone biosynthesis protein MenD (includes 2-succinyl-6-hydroxy- 2,4-cyclohexadiene-1-carboxylate synthase, 2-oxoglutarate decarboxylase) menD SW:MEND_BACSU (P23970; P23969; O34492) (580 aa) fasta scores: E(): 2.9e-21, 31.6% identity in 594 aa. Q9CBB0 No intermediary metabolism and respiration PF02776 Q9CBB0 GO:0000287,GO:0030145,GO:0009234,GO:0030976,GO:0070204 2.2.1.9 Rv0555 Rv0555 AL450380.2 Mycobrowser_v4 CDS 2087923 2089011 . + 0 ML1730 adhC PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC ML1730, len: 362 aa. Probable adhC, NADP-dependent alcohol dehydrogenase (EC 1.1.1.2). Highly similar to many Prokaryotic and Eukaryotic dehydrogenases including: Mycobacterium tuberculosis Rv3045 SW:ADH_MYCTU (P31975) (346 aa), Fasta scores: E(): 0, 85.8% identity in 346 aa overlap and Arabidopsis thaliana SW:CAD1_ARATH (P42734) (360 aa), Fasta scores: E(): 0, 48.8% identity in 344 aa overlap. Also similar to ML2053 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Note previously known as adhA. Q9CBQ3 No intermediary metabolism and respiration PF00107,PF08240 Q9CBQ3 GO:0016491,GO:0008270,GO:0055114 Rv3045 Rv3045 AL450380.2 Mycobrowser_v4 CDS 2751631 2752686 . - 0 ML2322c asd INVOLVED AT THE SECOND STEP IN THE COMMON BIOSYNTHETIC PATHWAY LEADING FROM ASP TO THE CELL WALL PRECURSOR MESO-DIAMINOPIMELATE, TO LYS, TO MET, TO ILE AND TO THR [CATALYTIC ACTIVITY: L-ASPARTATE-SEMIALDEHYDE + ORTHOPHOSPHATE + NADP(+) = L-ASPARTYL PHOSPHATE + NADPH]. ASPARTATE-SEMIALDEHYDE DEHYDROGENASE ASD (ASA DEHYDROGENASE) (ASADH) (ASPARTIC SEMIALDEHYDE DEHYDROGENASE) (L-ASPARTATE-BETA-SEMIALDEHYDE DEHYDROGENASE) ML2322c, len: 351 aa. asd, aspartate semialdehyde dehydrogenase (EC 1.2.1.11). Similar to Mycobacterium tuberculosis aspartate-semialdehyde dehydrogenase Rv3708c SW:DHAS_MYCTU (345 aa) fasta scores: E(): 0, 84.4% identity in 347 aa, and to Mycobacterium bovis aspartate-semialdehyde dehydrogenase SW:DHAS_MYCBO (345 aa) fasta scores: E(): 0, 82.1% identity in 347 aa. Contains Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase. Contains PS01103 Aspartate-semialdehyde dehydrogenase signature. Q9CB78 No intermediary metabolism and respiration PF01118,PF02774 Q9CB78 GO:0050661,GO:0004073,GO:0005737,GO:0009086,GO:0046983,GO:0009088,GO:0051287 1.2.1.11 Rv3708c Rv3708c AL450380.2 Mycobrowser_v4 CDS 2084630 2086354 . - 0 ML1728c ctaD CYTOCHROME C OXIDASE IS THE COMPONENT OF THE RESPIRATORY CHAIN THAT CATALYZES THE REDUCTION OF OXYGEN TO WATER. SUBUNITS 1-3 FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. CO I IS THE CATALYTIC SUBUNIT OF THE ENZYME. ELECTRONS ORIGINATING IN CYTOCHROME C ARE TRANSFERRED VIA THE COPPER A CENTER OF SUBUNIT 2 AND HEME A OF SUBUNIT 1 TO THE BIMETALLIC CENTER FORMED BY HEME A3 AND COPPER B [CATALYTIC ACTIVITY: 4 FERROCYTOCHROME C + O(2) = 2 H(2)O + 4 FERRICYTOCHROME C]. PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) ML1728c, len: 574 aa. Probable ctaD, cytochrome C oxidase, polypeptide I (EC 1.9.3.1). Highly similar to many cytochrome C oxidases including: Bacillus firmus SW:COX1_BACFI (Q04440) (624 aa), Fasta scores: E(): 0, 51.9% identity in 522 aa overlap and Mycobacterium tuberculosis Rv3043c SW:COX1_MYCTU (O53290) (573 aa), Fasta scores: E(): 0, 95.4% identity in 566 aa overlap. Contains Pfam match to entry PF00115 COX1, Cytochrome C and Quinol oxidase polypeptide I. Contains PS00077 Heme-copper oxidase catalytic subunit. Q9CBQ5 No intermediary metabolism and respiration PF00115 Q9CBQ5 GO:0005507,GO:0004129,GO:0009055,GO:0022900,GO:0020037,GO:0016021,GO:0005886,GO:0070469,GO:0006810,GO:0009060 1.9.3.1 Rv3043c Rv3043c AL450380.2 Mycobrowser_v4 CDS 2793929 2794924 . - 0 ML2352c drrA PROBABLY INVOLVED IN ACTIVE TRANSPORT OF ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE MEMBRANE (EXPORT). DRRA, DRRB|Rv2936|MTCY19H9.05 AND DRRC|Rv2938|MTCY19H9.06 MAY ACT JOINTLY TO CONFER DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM. PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA ML2352c, len: 331 aa. Probable drrA, daunorubicin-DIM-transport resistance ATP-binding protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport. Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2936 TR:P96205 (EMBL:Z83857) (331 aa) fasta scores: E(): 0, 85.2% identity in 331 aa and Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA SW:DRRA_STRPE (P32010) (330 aa) fasta scores: E(): 0, 46.0% identity in 322 aa. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. Q49938 No cell wall and cell processes PF00005 Q49938 GO:0005524,GO:0016887 Rv2936 Rv2936 AL450380.2 Mycobrowser_v4 CDS 1943808 1945373 . - 0 ML1622c ffh PROBABLE SIGNAL RECOGNITION PARTICLE PROTEIN FFH (FIFTY-FOUR HOMOLOG) (SRP PROTEIN) ML1622c, len: 521 aa. Probable ffh, signal recognition particle protein. Highly similar to many signal recognition particle proteins, involved in the reconition of the signal sequence and the efficient export of the protein, including: Bacillus subtilis SW:SR54_BACSU (P37105) (446 aa), Fasta scores: E(): 0, 51.0% identity in 435 aa overlap and Mycobacterium tuberculosis Rv2916c SW:SR54_MYCTU (Q10963) (525 aa), Fasta scores: E(): 0, 87.8% identity in 526 aa overlap. Contains Pfam match to entry PF00448 SRP54, SRP54-type protein. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O33013 No cell wall and cell processes PF00448,PF02881,PF02978 O33013 GO:0005525,GO:0006614,GO:0017111,GO:0005786,GO:0008312 Rv2916c Rv2916c AL450380.2 Mycobrowser_v4 CDS 2053124 2054617 . - 0 ML1702c gatA COMPONENT OF THE TRANSLATIONAL APPARATUS. FURNISHES A MEANS FOR FORMATION OF CORRECTLY CHARGED GLN-TRNA(GLN) THROUGH THE TRANSAMIDATION OF MISACYLATED GLU-TRNA(GLN) IN ORGANISMS WHICH LACK GLUTAMINYL-TRNA SYNTHETASE. THE REACTION TAKES PLACE IN THE PRESENCE OF GLUTAMINE AND ATP THROUGH AN ACTIVATED GAMMA-PHOSPHO-GLU-TRNA(GLN) [CATALYTIC ACTIVITY: ATP + L-GLUTAMYL-TRNA(GLN) + L-GLUTAMINE = ADP + PHOSPHATE + L-GLUTAMINYL-TRNA(GLN) + L-GLUTAMATE]. PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) ML1702c, len: 497 aa. Probable gatA, glutamyl-tRNA(Gln) amidotransferase, subunit A (EC 6.3.5.-). Highly similar to many glutamyl-tRNA(Gln) amidotransferases (subunit A) including: Bacillus subtilis SW:GATA_BACSU (O06491) (485 aa), Fasta scores: E(): 0, 50.8% identity in 476 aa overlap and Mycobacterium tuberculosis Rv3011c SW:GATA_MYCTU (O53258) (494 aa), Fasta scores: E(): 0, 88.5% identity in 494 aa overlap. Contains Pfam match to entry PF01425 Amidase, Amidase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE AMIDASE FAMILY O33105 No information pathways PF01425 O33105 GO:0050567,GO:0006412,GO:0005524 6.3.5.- Rv3011c Rv3011c AL450380.2 Mycobrowser_v4 CDS 2463426 2466284 . - 0 ML2072c gcvB THE GLYCINE CLEAVAGE SYSTEM CATALYSES THE DEGRADATION OF GLYCINE. THE P PROTEIN BINDS THE ALPHA-AMINO GROUP OF GLYCINE THROUGH ITS PYRIDOXAL PHOSPHATE COFACTOR; CO(2) IS RELEASED AND THE REMAINING METHYLAMINE MOIETY IS THEN TRANSFERRED TO THE LIPOAMIDE COFACTOR OF THE H PROTEIN [CATALYTIC ACTIVITY : GLYCINE + LIPOYLPROTEIN = S- AMINOMETHYLDIHYDROLIPOYLPROTEIN + CO(2)] Probable glycine dehydrogenase GcvB (Glycine decarboxylase) (Glycine cleavage system P-protein) ML2072c, len: 952 aa. Probable gcvB, glycine decarboxylase (EC 1.4.4.2). Similar to Mycobacterium tuberculosis probable glycine dehydrogenase [decarboxylating] SW:GCSP_MYCTU (Q50601) fasta scores: E(): 0, 84.7% in 942 aa, and to Escherichia coli glycine dehydrogenase [decarboxylating] SW:GCSP_ECOLI (P33195) fasta scores: E(): 0, 53.5% in 956 aa. O32915 No intermediary metabolism and respiration PF02347 O32915 GO:0004375,GO:0055114,GO:0030170,GO:0019464 1.4.4.2 Rv1832 Rv1832 AL450380.2 Mycobrowser_v4 CDS 2082428 2083345 . - 0 ML1726c ML1726c PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER ML1726c, len: 305 aa. Probable conserved ATP-binding protein ABC transporter. Highly similar to many putative ABC transport, ATP-binding proteins including: Streptomyces coelicolor TR:CAB76322 (EMBL:AL158060) (279 aa), Fasta scores: E(): 0, 44.4% identity in 277 aa overlap and Mycobacterium tuberculosis Rv3041c TR:O53288 (EMBL:AL021287) (287 aa), Fasta scores: E(): 0, 83.4% identity in 289 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Q9CBQ7 No cell wall and cell processes PF00005 Q9CBQ7 GO:0016887,GO:0005524 Rv3041c Rv3041c AL450380.2 Mycobrowser_v4 CDS 2700171 2701163 . + 0 ML2277 grcC1 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) ML2277, len: 330 aa. Probable grcC1, polyprenyl diphosphate synthase (EC 2.5.1.-). Similar to Mycobacterium tuberculosis polyprenyl diphosphate synthase Rv0562 or MTCY25D10.41 TR:O06428 (EMBL:Z95558) (335 aa) fasta scores: E(): 0, 76.4% identity in 335 aa and to Mycobacterium tuberculosis isoprene biosynthesis transferase Rv0989c or MTCI237.03C TR:O05572 (EMBL:Z94752) (325 aa) fasta scores: E(): 0, 53.6% identity in 323 aa. Similar to many polyprenyl synthase components e.g. Bacillus stearothermophilus heptaprenyl diphosphate synthase component ii hepT or heps-2 SW:HEP2_BACST (P55785) (320 aa) fasta scores: E(): 1.2e-31, 33.8% id in 320 aa. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases. Contains PS00444 Polyprenyl synthetases signature 2. Q9CBA5 No intermediary metabolism and respiration PF00348 Q9CBA5 GO:0008299 Rv0562 Rv0562 AL450380.2 Mycobrowser_v4 CDS 2453707 2455143 . + 0 ML2066 guaB1 PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) ML2066, len: 478 aa. Probable guaB1, inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). Previously sequenced as TR:O32912 (EMBL:AL008609) fasta scores: E(): 0, 100.0% in 478 aa. Similar to Mycobacterium tuberculosis inosine-5'-monophosphate dehydrogenase Rv1843c SW:YI43_MYCTU (Q50591) fasta scores: E(): 0, 86.4% in 478 aa, and to Bacillus subtilis inosine-5'-monophosphate dehydrogenase SW:IMDH_BACSU (P21879) fasta scores: E(): 0, 37.7% in 472 aa. Also similar to ML0387 and ML0388 from M. leprae. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus. O32912 No intermediary metabolism and respiration PF00478,PF00571 O32912 GO:0055114,GO:0003938 1.-.-.- Rv1843c Rv1843c AL450380.2 Mycobrowser_v4 CDS 2220221 2220766 . - 0 ML1832c kad THIS SMALL UBIQUITOUS ENZYME IS ESSENTIAL IN INTRACELLULAR NUCLEOTIDE METABOLISM, IN ADDITION IT HAS BEEN FOUND TO ACTS AS BOTH A NUCLEOSIDE MONO- AND DI-PHOSPHATE KINASE SUGGESTING IT MAY HAVE A ROLE IN RNA AND DNA BIOSYNTHESIS [CATALYTIC ACTIVITY: ATP + AMP = ADP + ADP]. PROBABLE ADENYLATE KINASE KAD (ATP-AMP TRANSPHOSPHORYLASE) ML1832c, len: 181 aa. Probable kad, adenylate kinase (EC 2.7.4.3). Similar to M. tuberculosis adenylate kinase kad Rv0733 SW:KAD_MYCTU (O53796) (181 aa), Fasta scores: E(): 0, 83.4% identity in 181 aa overlap, and to many thers e.g. Bacillus subtilis adenylate kinase SW:KAD_BACSU (P16304) (217 aa), Fasta scores: E(): 2.9e-20, 39.3% identity in 211 aa overlap. Contains Pfam match to entry PF00406 adenylatekinase, Adenylate kinase. Contains PS00113 Adenylate kinase signature. O33007 No intermediary metabolism and respiration PF00406 O33007 GO:0004017,GO:0005737,GO:0009165,GO:0005524 2.7.4.3 Rv0733 Rv0733 AL450380.2 Mycobrowser_v4 CDS 2005139 2005612 . - 0 ML1663c kdtB INVOLVED IN THE COENZYME A (CoA) BIOSYNTHESIS (AT THE FOURTH STEP). REVERSIBLY TRANSFERS AN ADENYLYL GROUP FROM ATP TO 4'-PHOSPHOPANTETHEINE, YIELDING DEPHOSPHO-CoA (DPCOA) AND PYROPHOSPHATE [CATALYTIC ACTIVITY: ATP + PANTETHEINE 4'-PHOSPHATE = DIPHOSPHATE + DEPHOSPHO-CoA]. PROBABLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE KDTB (PANTETHEINE- PHOSPHATE ADENYLYLTRANSFERASE) (PPAT) (DEPHOSPHO-CoA PYROPHOSPHORYLASE) ML1663c, len: 157 aa. Probable kdtB (alternate gene name: coaD), phosphopantetheine adenylyltransferase (EC 2.7.7.3). Highly similar to many phosphopantetheine adenylyltransferases involved in coenzyme A biosynthesis, including: Escherichia coli SW:COAD_ECOLI (P23875) (159 aa), Fasta scores: E(): 5.9e-25, 43.5% identity in 154 aa overlap and Mycobacterium tuberculosis Rv2965c SW:COAD_MYCTU (Q50452) (161 aa), Fasta scores: E(): 0, 85.6% identity in 153 aa overlap. Contains Pfam match to entry PF01467 Cytidylyltransf, Cytidylyltransferase. Note previously known as coaD. O69466 No cell wall and cell processes PF01467 O69466 GO:0015937,GO:0005737,GO:0004595,GO:0005524 2.7.7.3 Rv2965c Rv2965c AL450380.2 Mycobrowser_v4 CDS 2856888 2858291 . + 0 ML2387 lpd DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE) ML2387, len: 467 aa. Probable lpd, dihydrolipoamide dehydrogenase. Highly similar to many dihydrolipoamide dehydrogenases including: Mycobacterium tuberculosis Rv0462 TR:O53747 (EMBL:AL021933) (464 aa) fasta scores: E(): 0, 83.1% identity in 467 aa and Bacillus subtilis SW:DLD2_BACSU (P54533) (474 aa) fasta scores: E(): 0, 43.2% identity in 477 aa. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. Q50068 No intermediary metabolism and respiration PF00070,PF02852,PF07992 Q50068 GO:0045454,GO:0005737,GO:0004148,GO:0006096,GO:0055114,GO:0050660 1.8.1.4 Rv0462 Rv0462 AL450380.2 Mycobrowser_v4 CDS 2962283 2963143 . - 0 ML2489c ML2489c POSSIBLE CONSERVED SECRETED PROTEIN ML2489c, len: 286 aa. Possible conserved secreted protein. Similar to Mycobacterium tuberculosis hypothetical secreted protein Rv0383c or MTV036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% identity in 286 aa. Contains a possible N-terminal signal sequence. Q9CB27 No cell wall and cell processes Q9CB27 Rv0383c Rv0383c AL450380.2 Mycobrowser_v4 CDS 2115128 2116999 . - 0 ML1750c ML1750c conserved hypothetical protein ML1750c, len: 623 aa. Conserved hypothetical protein. The C-terminus of this protein is highly similar to many including several hypothetical proteins and putative phosphodiesterases e.g. Mycobacterium tuberculosis Rv1354c SW:YD54_MYCTU (Q11024) (623 aa), Fasta scores: E(): 0, 63.3% identity in 605 aa overlap and Streptomyces coelicolor TR:Q9Z584 (EMBL:AL035569) (746 aa), Fasta scores: E(): 0, 40.0% identity in 455 aa overlap. The C-terminus of the predicted product of this CDS is similar to ML1752 from M. leprae. Contains Pfam match to entry PF00990 DUF9, Domain of unknown function. Contains Pfam match to entry PF00563 DUF2, Domain of unknown function 2. Contains Pfam match to entry PF01590 GAF, GAF domain. Q9CBP6 No conserved hypotheticals PF00563,PF00990,PF01590 Q9CBP6 Rv1354c Rv1354c AL450380.2 Mycobrowser_v4 CDS 2358459 2360177 . + 0 ML1974 ML1974 POSSIBLE CONSERVED PERMEASE ML1974, len: 572 aa. Possible conserved permease. Similar to M. tuberculosis probable permease Rv1979c SW:YJ79_MYCTU (Q10875) (481 aa), Fasta scores: E(): 0, 76.8% identity in 462 aa overlap, and to e.g. Arabidopsis thaliana putative amino acid transporter TR:Q9SQZ0 (EMBL:AC011560) (584 aa), Fasta scores: E(): 2.1e-13, 23.0% identity in 508 aa overlap. Also similar to ML1304 and ML1305 from M. leprae. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBH5 No cell wall and cell processes PF00324 Q9CBH5 GO:0006865,GO:0016020,GO:0015171 Rv1979c Rv1979c AL450380.2 Mycobrowser_v4 CDS 2284613 2285473 . + 0 ML1900 mmaA1 INVOLVED IN MYCOLIC ACIDS MODIFICATION. CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a major constituent of the mycobacterial cell wall complex. Methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; Olefinic mycolic acid methyl transferase. METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) ML1900, len: 286 aa. Probable mmaA1, methyl mycolic acid synthase 1 (EC 2.1.1.-). Similar to M. tuberculosis methyl mycolic acid synthase 1 Rv0645c TR:P94922 (EMBL:U77466) (286 aa), Fasta scores: E(): 0, 87.4% identity in 286 aa overlap, and to many others e.g. M. tuberculosis cyclopropane-fatty-acyl-phospholipid synthase 1 SW:CFA1_MYCTU (Q11195) (287 aa), Fasta scores: E(): 0, 54.9% identity in 284 aa overlap. Also similar to ML2459, ML2426 and ML2334 from M. leprae. Q9CBK4 No lipid metabolism PF02353 Q9CBK4 GO:0008610,GO:0008825 Rv0645c Rv0645c AL450380.2 Mycobrowser_v4 CDS 2922797 2923900 . - 0 ML2447c murB PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE) ML2447c, len: 367 aa. Probable murA, UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158). Similar to Mycobacterium tuberculosis UDP-N-acetylenolpyruvoylglucosamine reductase Rv0482 SW:MURB_MYCTU (Q11148) fasta scores: E(): 0, 79.0% identity in 372 aa, and to Escherichia coli UDP-N-acetylenolpyruvoylglucosamine reductase MurB SW:MURB_ECOLI (P08373) fasta scores: E(): 3.6e-12, 35.5% identity in 352 aa. Contains Pfam match to entry PF02215 MurB, UDP-N-acetylenolpyruvoylglucosamine reductase. Q9CB48 No cell wall and cell processes PF01565,PF02873 Q9CB48 GO:0008762,GO:0007049,GO:0051301,GO:0007047,GO:0005737,GO:0055114,GO:0009252,GO:0008360,GO:0050660 1.1.1.158 Rv0482 Rv0482 AL450380.2 Mycobrowser_v4 CDS 2846834 2849713 . + 0 ML2378 mmpL4 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL4 ML2378, len: 959 aa. Probable mmpL4, conserved transmembrane protein. Similar to many membrane proteins including: Mycobacterium tuberculosis membrane protein MmpL4 or Rv0450c SW:MML4_MYCTU (O53735) (967 aa) fasta scores: E(): 0, 78.4% identity in 962 aa, and to Mycobacterium avium TmtpB TR:Q9XCF5 (EMBL:AF143772) (963 aa) fasta scores: E(): 0, 61.8% identity in 945 aa. Also similar to ML0259 a possible pseudogene similar to M. tuberculosis mmpL4. Contains multiple possible membrane spanning hydrophobic domains. P54881 No cell wall and cell processes PF03176 P54881 GO:0005886,GO:0016021 Rv0450c Rv0450c AL450380.2 Mycobrowser_v4 CDS 2160282 2161367 . + 0 ML1784 mscR Probable S-nitrosomycothiol reductase MscR ML1784, len: 361 aa. Probable mscR, S-nitrosomycothiol reductase. Similar to M. tuberculosis mscR Rv2259 TR:O53533 (EMBL:AL021925) (361 aa), Fasta scores: E(): 0, 88.9% identity in 361 aa overlap, and to other alcohol dehydrogenases e.g. Amycolatopsis methanolica NAD/mycothiol-dependent formaldehyde dehydrogenase SW:FADH_AMYME (P80094) (360 aa), Fasta scores: E(): 0, 80.4% identity in 358 aa overlap. Also similar to ML1730 and ML2053 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00190 Cytochrome c family heme-binding site signature. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Note previously known as adhE2. Q9CBN2 No intermediary metabolism and respiration PF00107,PF08240 Q9CBN2 GO:0016491,GO:0008270,GO:0055114 Rv2259 Rv2259 AL450380.2 Mycobrowser_v4 CDS 2094331 2096412 . - 0 ML1734c nrdE INVOLVED IN THE DNA REPLICATION PATHWAY. CATALYZES THE BIOSYNTHESIS OF DEOXYRIBONUCLEOTIDES FROM THE CORRESPONDING RIBONUCLEOTIDES, PRECURSORS THAT ARE NECESSARY FOR DNA SYNTHESIS. [CATALYTIC ACTIVITY: 2'-DEOXYRIBONUCLEOSIDE DIPHOSPHATE + OXIDIZED THIOREDOXIN + H(2)O = RIBONUCLEOSIDE DIPHOSPHATE + REDUCED THIOREDOXIN]. RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) ML1734c, len: 693 aa. Probable nrdE, ribonucleoside diphosphate reductase [alpha] chain (EC 1.17.4.1). Highly similar to Mycobacterium tuberculosis ribonucleoside-diphosphate reductase alpha chain (EC 1.17.4.1) Rv3051c SW:RIR1_MYCTU (P50640) (693 aa), Fasta scores: E(): 0, 93.2% identity in 693 aa overlap. Contains Pfam match to entry PF00317 ribonucleo_red, Ribonucleotide reductase. Contains PS00089 Ribonucleotide reductase large subunit signature. Q9CBQ0 No information pathways PF00317,PF02867,PF08343 Q9CBQ0 GO:0006260,GO:0055114,GO:0005515,GO:0004748,GO:0005971,GO:0005524 1.17.4.1 Rv3051c Rv3051c AL450380.2 Mycobrowser_v4 CDS 2790919 2792190 . - 0 ML2349c papA5 POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5 ML2349c, len: 423 aa. Possible papA5, conserved polyketide synthase (PKS) associated protein (see Camacho et al., 2001). Similar to Mycobacterium tuberculosis Rv2939 TR:P96208 (EMBL:Z83857) papA5, conserved polyketide synthase (PKS) associated protein (422 aa), fasta scores: E(): 0, 83.8% identity in 426 aa and Mycobacterium bovis SW:YMA3_MYCBO (Q02279) (354 aa) fasta scores: E(): 0, 81.6% identity in 347 aa. Q49939 No lipid metabolism Q49939 GO:0008610,GO:0008415 2.3.1.- Rv2939 Rv2939 AL450380.2 Mycobrowser_v4 CDS 2630076 2631407 . - 0 ML2213c pepC PROBABLE AMINOPEPTIDASE PEPC ML2213c, len: 443 aa. Probable pepC, aminopeptidase I (EC 3.4.11.-). Similar to Mycobacterium tuberculosis aminopeptidase Rv0800 OR MTCY07H7A.09C TR:O06634 (EMBL:Z95618) fasta scores: E(): 0, 78.3% identity in 433 aa, and to Saccharomyces cerevisiae vacuolar aminopeptidase I precursor ApE1 SW:AMPL_YEAST (P14904; P22060) fasta scores: E(): 5.7e-22, 31.5% identity in 454 aa. Contains Pfam match to entry PF02127 Peptidase_M18, Aminopeptidase I zinc metalloprotease (M18). Q50022 No intermediary metabolism and respiration PF02127 Q50022 GO:0008237,GO:0006508,GO:0005773,GO:0008270,GO:0004177 3.4.11.- Rv0800 Rv0800 AL450380.2 Mycobrowser_v4 CDS 2961008 2961547 . - 0 ML2487c pyrE PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) ML2487c, len: 179 aa. Probable pyrE, purine/pyrimidine phosphoribosyltransferase (EC 2.4.2.10). Similar to Mycobacterium tuberculosis purine/pyrimidine phosphoribosyltransferase Rv0382c or MTV036.17c TR:O53717 (EMBL:AL021931) fasta scores: E(): 0, 86.2% identity in 174 aa, and to Pyrococcus abyssi orotate phosphoribosyltransferase pyre or pab2430 SW:PYRE_PYRAB (P56814) fasta scores: E(): 7.6e-16, 37.1% identity in 175 aa. Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. Contains PS00589 PTS HPR component serine phosphorylation site signature. Q9CB28 No intermediary metabolism and respiration PF00156 Q9CB28 GO:0009116,GO:0004588,GO:0006221,GO:0000287 2.4.2.10 Rv0382c Rv0382c AL450380.2 Mycobrowser_v4 CDS 2732194 2734605 . + 0 ML2308 ponA2 INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FINAL STAGES), CELL WALL FORMATION. SYNTHESIS OF CROSS-LINKED PEPTIDOGLYCAN FROM THE LIPID INTERMEDIATES. THE ENZYME HAS A PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE N-TERMINAL DOMAIN (FORMATION OF LINEAR GLYCAN STRANDS) AND A PENICILLIN-SENSITIVE TRANSPEPTIDASE C-TERMINAL DOMAIN (CROSS-LINKING OF THE PEPTIDE SUBUNITS). SUPPOSED INVOLVED IN STATIONARY-PHASE SURVIVAL. PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)] ML2308, len: 803 aa. Probable ponA2, penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities. Previously characterised Mycobacterium leprae penicillin-binding protein Pon1 TR:P72351 (EMBL:S82044) (821 aa) fasta scores: E(): 0, 98.6% identity in 783 aa. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains Pfam match to entry PF00912 Transglycosyl, Transglycosylase. NOte previously known as pon1. Q9CB85 No cell wall and cell processes PF00905,PF00912,PF03793 Q9CB85 GO:0008658,GO:0009252,GO:0009274,GO:0008360,GO:0003824 Rv3682 Rv3682 AL450380.2 Mycobrowser_v4 CDS 2620622 2622292 . - 0 ML2206c purF AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) ML2206c, len: 556 aa. Probable purF, amidophosphoribosyltransferase (EC 2.4.2.14). Similar to Mycobacterium tuberculosis amidophosphoribosyltransferase precursor Rv0808 SW:PUR1_MYCTU (O06626) fasta scores: E(): 0, 91.3% identity in 518 aa, and to Bacillus subtilis amidophosphoribosyltransferase precursor PURF SW:PUR1_BACSU (P00497) fasta scores: E(): 0, 45.1% identity in 470 aa. Contains 2 Pfam matches to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Q50028 No intermediary metabolism and respiration PF00156,PF00310 Q50028 GO:0004044,GO:0006541,GO:0005506,GO:0000287,GO:0009116,GO:0009113,GO:0006164,GO:0051539 2.4.2.14 Rv0808 Rv0808 AL450380.2 Mycobrowser_v4 CDS 2014730 2016961 . - 0 ML1671c recG CRITICAL ROLE IN RECOMBINATION AND DNA REPAIR. HELP PROCESS HOLLIDAY JUNCTION INTERMEDIATES TO MATURE PRODUCTS BY CATALYSING BRANCH MIGRATION. HAS A DNA UNWINDING ACTIVITY CHARACTERISTIC OF A DNA HELICASE WITH A 3' TO 5' POLARITY. RECG UNWIND BRANCHED DUPLEX DNA (Y-DNA). PROBABLE ATP-DEPENDENT DNA HELICASE RECG ML1671c, len: 743 aa. Probable recG, ATP-dependent DNA helicase (EC 3.6.1.-). Highly similar to many ATP-dependent DNA helicases including: Staphylococcus aureus SW:RECG_STAAU (O50581) (686 aa), Fasta scores: E(): 2e-24, 35.7% identity in 701 aa overlap and Mycobacterium tuberculosis Rv2973c SW:RECG_MYCTU (P95122) (737 aa), Fasta scores: E(): 0, 79.4% identity in 744 aa overlap. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). O69460 No information pathways PF00270,PF00271,PF01336 O69460 GO:0004003,GO:0003677,GO:0006310,GO:0006281,GO:0005524 3.6.1.- Rv2973c Rv2973c AL450380.2 Mycobrowser_v4 CDS 2255797 2256987 . - 0 ML1877c tuf PROBABLE IRON-REGULATED ELONGATION FACTOR TU TUF (EF-TU) ML1877c, len: 396 aa. Probable tuf, iron-regulated elongation factor EF-Tu. Similar to M. tuberculosis elongation factor TU Rv0685 SW:EFTU_MYCTU (P31501) (396 aa), Fasta scores: E(): 0, 94.9% identity in 396 aa overlap, and to many others e.g. Escherichia coli SW:EFTU_ECOLI (P02990) (393 aa), Fasta scores: E(): 0, 74.9% identity in 395 aa overlap. Also similar to ML1498, ML1556, ML0611 and ML1878 from M. leprae. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains PS00301 GTP-binding elongation factors signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). P30768 No information pathways PF00009,PF03143,PF03144 P30768 GO:0003924,GO:0005737,GO:0003746,GO:0006414,GO:0005525 Rv0685 Rv0685 AL450380.2 Mycobrowser_v4 CDS 2326360 2327646 . + 0 ML1940 xseA BIDIRECTIONALLY DEGRADES SINGLE-STRANDED DNA INTO LARGE ACID-INSOLUBLE OLIGONUCLEOTIDES, WHICH ARE THEN DEGRADED FURTHER INTO SMALL ACID-SOLUBLE OLIGONUCLEOTIDES [CATALYTIC ACTIVITY: EXONUCLEOLYTIC CLEAVAGE IN EITHER 5'- TO 3'- OR 3'- TO 5'-DIRECTION TO YIELD 5'-PHOSPHOMONONUCLEOTIDES] PROBABLE EXODEOXYRIBONUCLEASE VII (LARGE SUBUNIT) XSEA (EXONUCLEASE VII LARGE SUBUNIT) ML1940, len: 428 aa. Probable xseA, exonuclease VII large subunit (EC 3.1.11.6). Similar to M. tuberculosis exonuclease VII large subunit xseA Rv1108c, and to many others e.g. Escherichia coli exodeoxyribonuclease large subunit SW:EX7L_ECOLI (P04994) (456 aa), Fasta scores: E(): 1.7e-28, 31.8% identity in 425 aa overlap. Q9X783 No information pathways PF01336,PF02601 Q9X783 GO:0005737,GO:0008855,GO:0009318,GO:0003676,GO:0006308 3.1.11.6 Rv1108c Rv1108c AL450380.2 Mycobrowser_v4 CDS 3033668 3035314 . - 0 ML2546c fadD2 PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) ML2546c, len: 548 aa. Probable fadD2, acyl-CoA ligase (EC 6.2.1.-). Similar to Rhizobium trifolii malonyl CoA synthetase MATB TR:Q9ZIP5 (EMBL:AF117694) fasta scores: E(): 2.4e-31, 31.2% identity in 507 aa and Mycobacterium tuberculosis hypothetical 59.9 kda protein Rv0270 TR:P95227 (EMBL:Z86089) fasta scores: E(): 0, 82.3% id in 558 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Q9CD27 No lipid metabolism PF00501 Q9CD27 GO:0008152,GO:0003824 Rv0270 Rv0270 AL450380.2 Mycobrowser_v4 CDS 2893807 2894796 . - 0 ML2419c hemB PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) ML2419c, len: 329 aa. Probable hemB, delta-aminolevulinic acid dehydratase (EC 4.2.1.24). Similar to many including: Mycobacterium tuberculosis delta-aminolevulinic acid dehydratase Rv0512 SW:HEM2_MYCTU (O33357) (329 aa) fasta scores: E(): 0, 87.5% identity in 329 aa, and to Escherichia coli delta-aminolevulinic acid dehydratase HemB SW:HEM2_ECOLI (P15002; P78247) (323 aa) fasta scores: E(): 0, 46.7% identity in 317 aa. Contains Pfam match to entry PF00490 ALAD, Delta-aminolevulinic acid dehydratase. Contains PS00169 Delta-aminolevulinic acid dehydratase active site. P46723 No intermediary metabolism and respiration PF00490 P46723 GO:0006779,GO:0008270,GO:0004655 4.2.1.24 Rv0512 Rv0512 AL450380.2 Mycobrowser_v4 CDS 2894843 2896534 . - 0 ML2420c hemD PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM) ML2420c, len: 563 aa. Probable hemD, uroporphyrin-III C-methyltransferase (EC 2.1.1.107). Similar to Mycobacterium tuberculosis Rv0511 TR:P95077 (EMBL:Z83865) (565 aa) fasta scores: E(): 0, 85.7% identity in 565 aa and to Clostridium josui porphyrin biosynthesis protein HemD [includes: uroporphyrin-III C-methyltransferase hemD SW:HEM4_CLOJO (Q59294) (504 aa) fasta scores: E(): 3e-24, 24.4% identity in 545 aa. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. Q9CB60 No intermediary metabolism and respiration PF00590,PF02602 Q9CB60 GO:0033014,GO:0004852,GO:0008168 Rv0511 Rv0511 AL450380.2 Mycobrowser_v4 CDS 2905498 2906382 . - 0 ML2430c proC PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C REDUCTASE) ML2430c, len: 294 aa. Probable proC, pyrroline-5-carboxylate reductase (EC 1.5.1.2). Similar to Mycobacterium tuberculosis pyrroline-5-carboxylate reductase Rv0500 SW:PROC_MYCTU (Q11141) (295 aa) fasta scores: E(): 0, 82.4% identity in 295 aa, and to Escherichia coli pyrroline-5-carboxylate reductase SW:PROC_ECOLI (P00373) (269 aa) fasta scores: E(): 1.2e-17, 34.0% identity in 285 aa. Contains Pfam match to entry PF01089 P5CR, Delta 1-pyrroline-5-carboxylate reductase. Contains PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. P46725 No intermediary metabolism and respiration PF03807 P46725 GO:0005737,GO:0055114,GO:0006561,GO:0004735,GO:0005488 1.5.1.2 Rv0500 Rv0500 AL450380.2 Mycobrowser_v4 CDS 2918008 2919294 . - 0 ML2443c mshA GLYCOSYLTRANSFERASE MSHA ML2443c, len: 428 aa. Probable mshA, glycosyltransferase (EC 2.4.1.-). Similar to many proteins on undefined function and possible transferases including: Mycobacterium tuberculosis glycosyltransferase Rv0486 SW:Y486_MYCTU (Q11152) (480 aa) fasta scores: E(): 0, 86.6% identity in 432 aa, and to Streptomyces coelicolor putative transferase TR:Q9Z5B7 (EMBL:AL035478) (406 aa) fasta scores: E(): 1.7e-30, 34.2% identity in 401 aa. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. P54138 No intermediary metabolism and respiration PF00534 P54138 GO:0016757,GO:0009058 2.4.-.- Rv0486 Rv0486 AL450380.2 Mycobrowser_v4 CDS 3085096 3086280 . - 0 ML2583c ML2583c Possible glycosyl transferase ML2583c, len: 394 aa. Possible glycosyl transferase. Similar to Mycobacterium tuberculosis hypothetical protein Rv0225 TR:P96407 (EMBL:Z92669) fasta scores: E(): 0, 84.9% identity in 383 aa and to Methanobacterium thermoautotrophicum LPS biosynthesis related protein TR:O26275 (EMBL:AE000805) fasta scores: E(): 9.9e-21, 29.3% identity in 375 aa. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. Q7APT7 No cell wall and cell processes PF00534 Q7APT7 GO:0009058 Rv0225 Rv0225 AL450380.2 Mycobrowser_v4 CDS 2966123 2967706 . + 0 ML2491 ML2491 CONSERVED HYPOTHETICAL PROTEIN ML2491, len: 527 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1754c TR:O06790 (EMBL:Z95890) (563 aa) fasta scores: E(): 5.9e-92, 61.49% identity in 548 aa, and to Mycobacterium smegmatis hypothetical 35.9 kda protein in asd 3'region SW:YASD_MYCSM (P41402) fasta scores: E(): 0.0048, 25.0% identity in 348 aa. Note start changed since original submission. Q9CB25 No conserved hypotheticals Q9CB25 Rv1754c Rv1754c AL450380.2 Mycobrowser_v4 CDS 2984308 2985174 . - 0 ML2503c rmlA ALPHA-D-GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE RMLA (DTDP-GLUCOSE SYNTHASE) (DTDP-GLUCOSE PYROPHOSPHORYLASE) ML2503c, len: 288 aa. Probable rmlA, glucose-1-phosphate thymidyltransferase (EC 2.7.7.24). Similar to Mycobacterium tuberculosis glucose-1-phosphate thymidylyltransferase Rv0334 TR:P72017 (EMBL:U55242) fasta scores: E(): 0, 86.9% id in 282 aa, and to Escherichia coli glucose-1-phosphate thymidylyltransferase RfbA SW:RBA2_ECOLI (P55253) fasta scores: E(): 0, 61.1% identity in 283 aa. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Q9CB18 No intermediary metabolism and respiration PF00483 Q9CB18 GO:0008879,GO:0045226 2.7.7.24 Rv0334 Rv0334 AL450380.2 Mycobrowser_v4 CDS 3037546 3038214 . + 0 ML2549 ML2549 conserved hypothetical protein ML2549, len: 222 aa. Conserved hypothetical protein. Similar to several proteins of undefined function including: Mycobacterium tuberculosis hypothetical protein Rv0264c TR:P95221 (EMBL:Z86089) fasta scores: E(): 0, 75.2% identity in 202 aa, and to Escherichia coli hypothetical protein SW:YBGJ_ECOLI (P75744) fasta scores: E(): 9.5e-20, 40.1% identity in 182 aa. Q9CD26 No conserved hypotheticals PF02682 Q9CD26 Rv0264c Rv0264c AL450380.2 Mycobrowser_v4 CDS 3055237 3057072 . + 0 ML2563 fadE5 PROBABLE ACYL-CoA DEHYDROGENASE FADE5 ML2563, len: 611 aa. Probable fadE5, acyl-CoA dehydrogenase (EC 1.3.99.-). Similar to Mycobacterium tuberculosis putative acyl-CoA dehydrogenase Rv0244c TR:O53666 (EMBL:AL021929) fasta scores: E(): 0, 89.4% identity in 611 aa. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. O69506 No lipid metabolism PF00441,PF02770 O69506 GO:0003995,GO:0009055,GO:0008152,GO:0050660 Rv0244c Rv0244c AL450380.2 Mycobrowser_v4 CDS 3082931 3084733 . + 0 ML2582 ML2582 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2582, len: 600 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 59.1 kda protein Rv0226c OR MTCY08D5.21C TR:P96408 (EMBL:Z92669) fasta scores: E(): 0, 70.1% identity in 581 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. Q9CD17 No cell wall and cell processes Q9CD17 Rv0226c Rv0226c AL450380.2 Mycobrowser_v4 CDS 3094813 3096372 . + 0 ML2591 mce1C MCE-FAMILY PROTEIN MCE1C ML2591, len: 519 aa. mce1C, Mce-family protein. Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. Rv0171 TR:O07415 (EMBL:Z97050) fasta scores: E(): 0, 72.4% identity in 525 aa. Orthologue of M. tuberculosis Mce1C (Rv0171). Contains a possible N-terminal signal sequence. Q9CD12 No virulence, detoxification, adaptation PF02470 Q9CD12 Rv0171 Rv0171 AL450380.2 Mycobrowser_v4 CDS 3099133 3100683 . + 0 ML2594 mce1F MCE-FAMILY PROTEIN MCE1F ML2594, len: 516 aa. mce1F, Mce-family protein. Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. Rv0174 TR:O07418 (EMBL:Z97050) fasta scores: E(): 0, 76.5% identity in 515 aa. Orthologue of M. tuberculosis Mce1F (Rv0174). Contains a possible N-terminal signal sequence. Q9CD09 No virulence, detoxification, adaptation PF02470 Q9CD09 Rv0174 Rv0174 AL450380.2 Mycobrowser_v4 CDS 3072692 3074065 . + 0 ML2573 gabD PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD ML2573, len: 457 aa. Probable gabD, succinate-semialdehyde dehydrogenase (EC 1.2.1.16). Similar to Mycobacterium tuberculosis GabD1 OR Rv0234c TR:P96417 (EMBL:Z92669) fasta scores: E(): 0, 82.9% identity in 479 aa, and to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD SW:GABD_ECOLI (P25526) fasta scores: E(): 0, 35.4% identity in 460 aa. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS00070 Aldehyde dehydrogenases cysteine active site. O69497 No intermediary metabolism and respiration PF00171 O69497 GO:0009013,GO:0006099,GO:0055114 1.2.1.16 Rv0234c Rv0234c AL450380.2 Mycobrowser_v4 CDS 2963228 2965774 . - 0 ML2490c clpB PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1) ML2490c, len: 848 aa. Probable clpB, endopeptidase ATP binnding protein. Similar to Mycobacterium tuberculosis ClpB protein Rv0384c SW:CLPB_MYCTU (O53719) fasta scores: E(): 0, 89.0% identity in 848 aa, and to Escherichia coli protein ClpB TR:BAA16476 (EMBL:D90887) fasta scores: E(): 0, 54.8% id in 847 aa. Also similar to ML0235 from M. leprae. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00870 Chaperonins clpA/B signature 1. Contains PS00871 Chaperonins clpA/B signature 2. Q9CB26 No virulence, detoxification, adaptation PF00004,PF02861,PF07724,PF10431 Q9CB26 GO:0005737,GO:0017111,GO:0005515,GO:0019538,GO:0006950,GO:0005524 Rv0384c Rv0384c AL450380.2 Mycobrowser_v4 CDS 2926564 2927244 . - 0 ML2451c deoC PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE) ML2451c, len: 226 aa. Probable deoC, deoxyribose-phosphate aldolase (EC 4.1.2.4). Similar to Mycobacterium tuberculosis deoxyribose-phosphate aldolase Rv0478 SW:DEOC_MYCTU (Q11138) fasta scores: E(): 0, 78.6% identity in 224 aa, and to Bacillus subtilis deoxyribose-phosphate aldolase DeoC SW:DEOC_BACSU (P39121) fasta scores: E(): 9.9e-24, 44.7% identity in 206 aa. Contains Pfam match to entry PF01791 DeoC, Deoxyribose-phosphate aldolase. Q9CB45 No intermediary metabolism and respiration PF01791 Q9CB45 GO:0005737,GO:0009264,GO:0004139,GO:0016052 4.1.2.4 Rv0478 Rv0478 AL450380.2 Mycobrowser_v4 CDS 3230323 3232137 . - 0 ML2680c dnaB PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase ML2680c, len: 604 aa. Probable dnaB, replicative DNA helicase(EC 3.6.1.-). Similar to Mycobacterium tuberculosis replicative DNA helicase Rv0058 SW:DNAB_MYCTU (P71715) fasta scores: E(): 0, 66.6% in 554 aa, and to Escherichia coli replicative DNA helicase SW:DNAB_ECOLI (P03005) fasta scores: E(): 5.3e-31, 29.6% in 585 aa. Note the M. leprae DnaB orthologue contains an intein (approximately between residues 274..418). Contains a probable helix-turn-helix motif at aa 505-526 (Score 1068, SD +2.82) Contains Pfam match to entry PF00772 DnaB, DnaB-like helicase. Belongs to the helicase family. DnaB subfamily. P46394 No information pathways PF00772,PF03796 P46394 GO:0003677,GO:0003678,GO:0006269,GO:0005658,GO:0016539,GO:0005524 3.6.1.- Rv0058 Rv0058 AL450380.2 Mycobrowser_v4 CDS 3058972 3060336 . + 0 ML2565 fabG4 PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG4 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) ML2565, len: 454 aa. Probable fabG4, 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100). Highly similar to Mycobacterium tuberculosis fabG4, 3-oxoacyl-[acyl-carrier protein] reductase Rv0242c TR:O53665 (EMBL:AL021929) fasta scores: E(): 0, 84.8% id in 454 aa. The C-terminal portion of the predicted product of this CDS is similar to many 3-oxoacyl-[acyl-carrier protein] reductases e.g. Vibrio harveyi FabG SW:FABG_VIBHA (P55336) fasta scores: E(): 4.5e-27, 41.1% identity in 241 aa. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. O69504 No lipid metabolism PF00106 O69504 GO:0008152,GO:0016491,GO:0005488 Rv0242c Rv0242c AL450380.2 Mycobrowser_v4 CDS 2897502 2898905 . - 0 ML2422c hemA PROBABLE GLUTAMYL-TRNA REDUCTASE HEMA (GLUTR) ML2422c, len: 467 aa. Probable hemA, glutamyl-tRNA reductase (EC 1.2.1.-). Similar to Mycobacterium tuberculosis glutamyl-tRNA reductase Rv0509 SW:HEM1_MYCTU (Q11139) (468 aa) fasta scores: E(): 0, 82.3% identity in 463 aa, and to Bacillus subtilis glutamyl-tRNA reductase SW:HEM1_BACSU (P16618) (455 aa) fasta scores: E(): 0, 30.3% identity in 458 aa. Contains Pfam match to entry PF00745 GlutR, Glutaminyl-tRNA reductase. Contains PS00747 Glutamyl-tRNA reductase signature. P46724 No intermediary metabolism and respiration PF00745,PF01488,PF05201 P46724 GO:0005737,GO:0008883,GO:0055114,GO:0006779,GO:0004764,GO:0050661 1.2.1.70 Rv0509 Rv0509 AL450380.2 Mycobrowser_v4 CDS 2940912 2941700 . + 0 ML2467 ML2467 CATALYZES THE FIRST COMMITTED STEP IN THE SYNTHESIS OF DECAPRENYL DIPHOSPHATE, A MOLECULE WHICH HAS A CENTRAL ROLE IN THE BIOSYNTHESIS OF MOST FEATURES OF THE MYCOBACTERIAL CELL WALL. ADDS ONE ISOPRENE UNIT TO OMEGA,E-GERANYL DIPHOSPHATE. THE PRODUCT, OMEGA,E, Z-FARNESYL DIPHOSPHATE, IS THE PUTATIVE SUBSTRATE OF Rv2361c PRODUCT [CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate]. SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) (Z-FPP SYNTHETASE) (Z-FARNESYL DIPHOSPHATE SYNTHETASE) (GERANYLTRANSTRANSFERASE) (FARNESYL PYROPHOSPHATE SYNTHETASE) ML2467, len: 262 aa. Possible short chain Z-isoprenyl diphosphate synthetase (EC 2.5.1.10). Similar to Mycobacterium tuberculosis short chain Z-isoprenyl diphosphate synthetase Rv1086 SW:YA86_MYCTU (O53434) fasta scores: E(): 0, 90.5% identity in 262 aa and to Synechocystis sp. undecaprenyl pyrophosphate synthetase SW:UPPS_SYNY3 (Q55482) fasta scores: E(): 5.2e-29, 40.2% identity in 239 aa. Contains Pfam match to entry PF01255 UPP_synthetase, Putative undecaprenyl diphosphate synthase. Contains PS01066 Undecaprenyl pyrophosphate synthetase family signature. Q9CB36 No cell wall and cell processes PF01255 Q9CB36 GO:0007047,GO:0009252,GO:0008360,GO:0033850 2.5.1.68 Rv1086 Rv1086 AL450380.2 Mycobrowser_v4 CDS 2980189 2982831 . + 0 ML2501 ML2501 PROBABLE IRON-SULFUR-BINDING REDUCTASE ML2501, len: 880 aa. Probable iron-sulphur-binding reductase. Similar to Mycobacterium tuberculosis hypothetical protein Rv0338c TR:O33268 (EMBL:Z97991) fasta scores: E(): 0, 78.1% identity in 894 aa, and to Streptomyces coelicolor putative iron-sulphur-binding reductase SCH35.51C TR:Q9X8V5 (EMBL:AL078610) fasta scores: E(): 0, 48.2% id in 776 aa. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00037 fer4, 4Fe-4S binding domain. Contains PS00070 Aldehyde dehydrogenases cysteine active site. Contains 2 x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. Q9CB20 No intermediary metabolism and respiration PF02754 Q9CB20 GO:0051536,GO:0016491,GO:0009055 Rv0338c Rv0338c AL450380.2 Mycobrowser_v4 CDS 3185869 3187515 . - 0 ML2661c fadD7 PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) ML2661c, len: 548 aa. Probable fadD7, fatty-acid-CoA synthase (EC 6.2.1.-). Similar to many Prokaryotic and Eukaryotic acyl-CoA synthases including: Mycobacterium tuberculosis fadD7 protein Rv0119 TR:O07169 (EMBL:Z96071) fasta scores: E(): 0, 71.3% in 520 aa, and to Saccharomyces cerevisiae peroxisomal-coenzyme a synthetase SW:FAT2_YEAST (P38137) fasta scores: E(): 0, 35.6% in 526 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Q9CCY8 No lipid metabolism PF00501 Q9CCY8 GO:0008152,GO:0003824 Rv0119 Rv0119 AL450380.2 Mycobrowser_v4 CDS 3065565 3069782 . + 0 ML2570 ML2570 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2570, len: 1405 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0236c TR:P96419 (EMBL:Z92669) fasta scores: E(): 0, 78.7% identity in 1397 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. Q9CD19 No cell wall and cell processes PF00754 Q9CD19 GO:0007155 Rv0236c Rv0236c AL450380.2 Mycobrowser_v4 CDS 3264173 3264919 . - 0 ML2708c gidB PROBABLE GLUCOSE-INHIBITED DIVISION PROTEIN B GIDB (Methyltransferase) ML2708c, len: 248 aa. Probable gidB, Glucose inhibited division protein B (EC 2.1.-.-). Similar to Mycobacterium paratuberculosis putative glucose inhibited division protein B TR:AAF33688 (EMBL:AF222789) fasta scores: E(): 0, 64.2% in 243 aa, and to Mycobacterium tuberculosis glucose inhibited division protein B SW:GIDB_MYCTU (O53597) fasta scores: E(): 0, 68.4% in 212 aa. Belongs to the gidB family. Q50203 No cell wall and cell processes PF02527 Q50203 GO:0005737,GO:0008649,GO:0006364,GO:0007049 2.1.1.- Rv3919c Rv3919c AL450380.2 Mycobrowser_v4 CDS 3194558 3196414 . - 0 ML2667c ML2667c possible membrane transport protein ML2667c, len: 618 aa. Possible membrane transport protein. Similar to several manganese transport proteins e.g. Pseudomonas aeruginosa manganese transport protein MntH1 SW:MNT1_PSEAE (Q9RPF3) fasta scores: E(): 6.5e-13, 27.4% in 420 aa, and to Deinococcus radiodurans probable manganese transport protein MntH SW:MNTH_DEIRA (Q9RTP8) fasta scores: E(): 4e-15, 27.2% in 419 aa. Also similar to Q8VP26 Natural resistance-associated macrophage protein from Burkholderia cenocepacia (548 aa), fasta scores: E(): 8.3e-90, (48.700% identity in 577 aa overlap). Contains possible membrane spanning hydrophobic domains. Q9CCY6 No cell wall and cell processes Q9CCY6 GO:0006810,GO:0005215,GO:0016020 AL450380.2 Mycobrowser_v4 CDS 3197970 3199970 . - 0 ML2670c ML2670c POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE ML2670c, len: 666 aa. Possible transmembrane acyltransferase (EC 2.3.1.-). Similar to Mycobacterium tuberculosis transmembrane acetyltransferase TR:O53633 (EMBL:AL021926) fasta scores: E(): 0, 78.6% in 681 aa. Also similar to Salmonella typhimurium OafA, a member of the integral membrane trans-acylases TR:P74874 (EMBL:U65941) fasta scores: E(): 7.9e-16, 25.2% in 658 aa. Contains multiple possible membrane spanning hydrophobic domains. Contains 2 Pfam matches to entry PF01757 DUF33, Domain of unknown function. Q9CCY5 No intermediary metabolism and respiration PF01757 Q9CCY5 GO:0016747 Rv0111 Rv0111 AL450380.2 Mycobrowser_v4 CDS 3265654 3266796 . - 0 ML2710c ML2710c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2710c, len: 380 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis putative membrane protein Rv3921c TR:O53599 (EMBL:AL021426) fasta scores: E(): 0, 77.1% in 380 aa, and to Streptomyces coelicolor inner membrane protein TR:O54569 (EMBL:AF031590) fasta scores: E(): 1.8e-18, 29.0% in 366 aa. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF02096 60KD_IMP, 60Kd inner membrane protein. Q50205 No cell wall and cell processes PF02096 Q50205 GO:0005886,GO:0051205,GO:0016021 Rv3921c Rv3921c AL450380.2 Mycobrowser_v4 CDS 3225410 3228091 . + 0 ML2679 ML2679 Conserved hypothetical protein ML2679, len: 893 aa. Conserved hypothetical protein. Similar in parts to many proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical 95.4 kda protein Rv2567 SW:YP67_MYCTU (Q50654; Q50731) fasta scores: E(): 0, 75.2% in 883 aa. Similar to ML0605 and ML0507 (psuedogene). Q7APS0 No conserved hypotheticals PF04168,PF04169,PF04174 Q7APS0 Rv2567 Rv2567 AL450380.2 Mycobrowser_v4 CDS 3248277 3249737 . - 0 ML2697c pcnA PROBABLE POLY(A) POLYMERASE PCNA (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) (NTP POLYMERASE) (RNA ADENYLATING ENZYME) (POLY(A) POLYMERASE) ML2697c, len: 486 aa. Probable pcnA, polynucleotide polymerase (EC 2.7.7.19). Similar to several polynucleotide polymerases (EC 2.7.7.19) including Mycobacterium tuberculosis TR:O05438 (EMBL:Z94121) fasta scores: E(): 0, 83.9% in 478 aa, and Bacillus subtilis poly SW:PAPS_BACSU (P42977) fasta scores: E(): 1.4e-24, 30.3% in 456 aa. Contains Pfam match to entry PF01966 HD, HD domain. Contains Pfam match to entry PF01743 PolyA_pol, Poly A polymerase family. Contains PS00018 EF-hand calcium-binding domain. Q9CCY1 No information pathways PF01743,PF01966 Q9CCY1 GO:0006396,GO:0016787,GO:0000166,GO:0016779,GO:0003723 Rv3907c Rv3907c AL450380.2 Mycobrowser_v4 CDS 1853565 1854770 . - 0 ML1537c eccE5 ESX CONSERVED COMPONENT ECCE5. PROBABLE MEMBRANE PROTEIN. ML1537c, len: 401 aa. Conserved membrane protein. Highly similar to a protein of unknown function from Mycobacterium tuberculosis Rv1797 TR:O53946 (EMBL:AL022021) (406 aa), Fasta scores: E(): 0, 68.5% identity in 406 aa overlap. Contains a possible N-terminal signal sequence and a possible membrane spanning hydrophobic domain. Contains PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. Q9CBV4 No cell wall and cell processes Q9CBV4 Rv1797 Rv1797 AL450380.2 Mycobrowser_v4 CDS 3253066 3256686 . + 0 ML2700 ML2700 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2700, len: 1206 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical 123.6 kda protein Rv3910 TR:O05435 (EMBL:Z94121) fasta scores: E(): 0, 75.1% in 1182 aa. Also the N-terminus is similar to several virulence associated proteins e.g. Salmonella typhimurium virulence factor MviN SW:MVIN_SALTY (P37169) fasta scores: E(): 3e-17, 29.0% in 527 aa. Contains multiple possible membrane spanning hydrophobic domains. Q9CCX9 No cell wall and cell processes PF03023 Q9CCX9 GO:0009405,GO:0016021 Rv3910 Rv3910 AL450380.2 Mycobrowser_v4 CDS 3259768 3260988 . + 0 ML2704 ML2704 PROBABLE HYDROLASE ML2704, len: 406 aa. Probable hydrolase. Similar to Mycobacterium tuberculosis putative hydrolase Rv3915 TR:O53593 (EMBL:AL021426) fasta scores: E(): 0, 86.9% in 406 aa. Contains 2 Pfam matches to entry PF01471 PG_binding_1, Putative peptidoglycan binding domain. Contains Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase. Q9CCX8 No intermediary metabolism and respiration PF01471,PF01520 Q9CCX8 GO:0009253,GO:0008745 Rv3915 Rv3915 AL450380.2 Mycobrowser_v4 CDS 3262117 3263124 . - 0 ML2706c parB PROBABLE CHROMOSOME PARTITIONING PROTEIN PARB ML2706c, len: 335 aa. Probable parB, chromosome partitioning protein. Similar to many proteins thought to be involved with chromosome partitioning e.g. Mycobacterium tuberculosis hypothetical 37.0 kda protein Rv3917c TR:O53595 (EMBL:AL021426) fasta scores: E(): 0, 78.6% in 332 aa, and to Streptomyces coelicolor ParB TR:Q9RFM2 (EMBL:AF187159) fasta scores: E(): 0, 50.7% in 347 aa, and to Bacillus subtilis stage 0 sporulation protein J SW:SP0J_BACSU (P26497) fasta scores: E(): 1.7e-28, 42.3% in 272 aa. Contains Pfam match to entry PF02195 ParBc, ParB-like nuclease domain. Q50201 No cell wall and cell processes PF02195 Q50201 GO:0007059,GO:0003677 Rv3917c Rv3917c AL450380.2 Mycobrowser_v4 CDS 3267135 3267497 . - 0 ML2712c rnpA RNaseP CATALYZES THE REMOVAL OF THE 5'-LEADER SEQUENCE FROM PRE-tRNA TO PRODUCE THE MATURE 5'TERMINUS. IT CAN ALSO CLEAVE OTHER RNA SUBSTRATES SUCH AS 4.5S RNA. THE PROTEIN COMPONENT PLAYS AN AUXILIARY BUT ESSENTIAL ROLE IN VIVO BY BINDING TO THE 5'-LEADER SEQUENCE AND BROADENING THE SUBSTRATE SPECIFICITY OF THE RIBOZYME [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE OF RNA, REMOVING 5'-EXTRA-NUCLEOTIDE FROM tRNA PRECURSOR]. RIBONUCLEASE P PROTEIN COMPONENT RNPA (RNaseP PROTEIN) (RNase P PROTEIN) (PROTEIN C5) ML2712c, len: 120 aa. rnpA, ribonuclease P protein component (EC 3.1.26.5). Similar to Mycobacterium tuberculosis ribonuclease P protein component Rv3923c SW:RNPA_MYCTU (Q50789; O53601) fasta scores: E(): 2.9e-26, 63.0% in 119 aa, and to Streptomyces bikiniensis ribonuclease P protein component SW:RNPA_STRBI (P25817) fasta scores: E(): 1.1e-08, 34.8% in 115 aa. Contains Pfam match to entry PF00825 Ribonuclease_P, Ribonuclease P. Contains PS00648 Bacterial ribonuclease P protein component signature. P46610 No information pathways PF00825 P46610 GO:0001682,GO:0000049,GO:0004526 3.1.26.5 Rv3923c Rv3923c AL450380.2 Mycobrowser_v4 CDS 3258259 3259635 . + 0 ML2703 trxC THIOREDOXIN PARTICIPATES IN VARIOUS REDOX REACTIONS THROUGH THE REVERSIBLE OXIDATION OF ITS ACTIVE CENTER DITHIOL, TO A DISULFIDE, & CATALYZES DITHIOL-DISULFIDE EXCHANGE REACTIONS. FORMS TOGETHER WITH THIOREDOXIN REDUCTASE AND NADPH A REDOX ACTIVE SYSTEM WHICH DONATES ELECTRONS TO A WIDE VARIETY OF DIFFERENT METABOLIC PROCESS. SEEMS REGULATED BY SIGH (Rv3223c PRODUCT). THIOREDOXIN TRXC (TRX) (MPT46) ML2703, len: 458 aa. Probable trxC, Thioredoxin Previously sequenced and characterised: Mycobacterium leprae bifunctional thioredoxin reductase/thioredoxin [includes: thioredoxin reductase SW:TRXB_MYCLE (P46843) fasta scores: E(): 0, 100.0% in 458 aa. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Contains PS00194 Thioredoxin family active site. Note previously known as trxB. P46843 No intermediary metabolism and respiration PF00070,PF00085,PF07992 P46843 GO:0045454,GO:0005737,GO:0009055,GO:0022900,GO:0006662,GO:0015035,GO:0019430,GO:0004791,GO:0006810,GO:0050660 1.8.1.9 Rv3914 Rv3914 AL450380.2 Mycobrowser_v4 CDS 3241430 3242539 . + 0 ML2692 ML2692 Probable myo-inositol-1-phosphate synthase Ino1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase) ML2692, len: 369 aa. Probable ino1 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below). Identical to ML0396c a possible paralogue of M. tuberculosis ino1. Equivalent to Rv0046c|P71703|AL123456 ino1, myo-inositol-1-phosphate synthase from M. tuberculosis (367 aa), Fasta scores: E(): 0, (91.8% identity in 366 aa overlap). Highly similar to other bacterial myo-inositol-1-phosphate synthase and hypothetical proteins e.g. Q8NLE6 Myo-inositol-1-phosphate synthase from Corynebacterium glutamicum (363 aa), Fasta scores: E(): 0, (73.9% identity in 361 aa overlap); and Q9X8T5|SCH24_21c Hypothetical protein from Streptomyces coelicolor (360 aa). Contains Pfam match to entry PF01658 Inos-1-P_synth, Myo-inositol-1-phosphate synthase. Q57240 No intermediary metabolism and respiration PF01658,PF07994 Q57240 GO:0006021,GO:0004512,GO:0008654,GO:0005488 Rv0046c Rv0046c AL450380.2 Mycobrowser_v4 CDS 3210656 3212896 . - 0 ML2672c icd2 PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) ML2672c, len: 746 aa. Probable icd2, isocitrate dehydrogenase [NADP] (EC 1.1.1.42). Similar to Vibrio sp isocitrate dehydrogenase [NADP] 2 SW:IDH2_VIBA1 (P41561) fasta scores: E(): 0, 59.6% in 741 aa and to Mycobacterium tuberculosis Rv0066c isocitrate dehydrogenase TR:O53611 (EMBL:AL021428) fasta scores: E(): 0, 85.4% in 745 aa. O53115 No intermediary metabolism and respiration PF03971 O53115 GO:0006099,GO:0004450 Rv0066c Rv0066c AL450380.2 Mycobrowser_v4 CDS 3234977 3236671 . - 0 ML2687c ML2687c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ML2687c, len: 564 aa. Probable conserved transmembrane protein. Similar to Mycobacterium tuberculosis hypothetical transmembrane protein cy21d4.14 Rv0051 TR:P71708 (EMBL:Z80775) fasta scores: E(): 0, 78.7% in 531 aa, and to Streptomyces coelicolor hypothetical 44.5 kda protein TR:Q9X7Z2 (EMBL:AL049497) fasta scores: E(): 1.1e-06, 29.6% in 416 aa. Also similar to ML0471 a possible pseudogene similar to M. tuberculosis Rv0051. Contains multiple possible membrane spanning hydrophobic domains. Q7APR9 No cell wall and cell processes Q7APR9 GO:0016021 Rv0051 Rv0051 AL450380.2 Mycobrowser_v4 CDS 3122785 3125826 . - 0 ML2617c mmpL11 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11 ML2617c, len: 1013 aa. Probable mmpL11, conserved transmembrane transportprotein. Similar to Mycobacterium tuberculosis putative membrane protein Mmpl11 Rv0202c SW:MMLB_MYCTU (O53653) fasta scores: E(): 0, 72.8% identity in 1017 aa, and to Streptomyces coelicolor putative integral membrane protein SC3A4.16C TR:CAB89762 (EMBL:AL354616) fasta scores: E(): 0, 31.8% identity in 761 aa. Also similar to ML2620 from M. leprae. Contains a possible N-terminal signal sequence and multiple other possible membrane spanning hydrophobic domains. O06079 No cell wall and cell processes O06079 GO:0005886,GO:0016021 Rv0202c Rv0202c AL450380.2 Mycobrowser_v4 CDS 3061377 3062279 . + 0 ML2566 htdX conserved hypothetical protein ML2566, len: 300 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0241c TR:O53664 (EMBL:AL021929) fasta scores: E(): 0, 81.8% identity in 280 aa, and to Streptomyces coelicolor putative dehydratase TR:CAB77291 (EMBL:AL160312) fasta scores: E(): 2.1e-27, 39.5% identity in 271 aa. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00211 ABC transporters family signature. Q9CD22 No conserved hypotheticals, intermediary metabolism and respiration PF01575 Q9CD22 GO:0005835,GO:0004312,GO:0016491,GO:0006633 Rv0241c Rv0241c AL450380.2 Mycobrowser_v4 CDS 1240281 1240700 . + 0 ML1077 rseA conserved hypothetical protein ML1077, len: 139 aa. Conserved hypothetical protein. Highly similar to anti-sigma factor rseA from Mycobacterium tuberculosis Rv1222 (regulates negatively sigE), Fasta scores: E(): 0, 70.7% identity in 150 aa overlap; and Mycobacterium avium TR:O05736 (EMBL:U87308) (133 aa), Fasta scores: E(): 0, 71.7% identity in 138 aa overlap; and Mycobacterium smegmatis TR:O05768 (EMBL:U87307) (145 aa), Fasta scores: E(): 0, 66.2% identity in 139 aa overlap. Q9CCA5 No conserved hypotheticals, information pathways Q9CCA5 Rv1222 Rv1222 AL450380.2 Mycobrowser_v4 CDS 243054 244202 . + 0 ML0176 pepD Probable serine protease (serine proteinase) ML0176, len: 382 aa. Probable secreted or membrane serine protease (EC 3.4.21.-), highly similar to Rv0983|O53896|AL123456 probable serine protease from M. tuberculosis (464 aa), Fasta scores: E(): 0, (80.7% identity in 383 aa overlap); and in part to Rv1223|O06291|AL123456 htrA, putative serine protease from M. tuberculosis (549 aa), Fasta scores: E(): 0, (41.8% identity in 347 aa overlap). Similar to many putative serine protease e.g. Q8NS10 trypsin-like serine protease from Corynebacterium glutamicum (413 aa), Fasta scores: E(): 1.3e-35, 47.2% identity in 362 aa overlap. Also similar to ML1078 and ML2659 from M. leprae. Previously sequenced as Q9Z5G6|AL035500 (452 aa), Fasta scores: E(): 0, (100.0% identity in 382 aa overlap). Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains Pfam match to entry PF00089 trypsin, Trypsin. Q9CD67 No intermediary metabolism and respiration PF00089 Q9CD67 GO:0006508,GO:0004252,GO:0005515 Rv0983 Rv0983 AL450380.2 Mycobrowser_v4 CDS 117870 118778 . + 0 ML0095 ubiA Possible conserved integral membrane protein ML0095, len: 302 aa. Possible conserved integral membrane protein, highly similar to Rv3806c|O53583|AL123456 integral membrane protein from M. tuberculosis (302 aa), Fasta scores: E(): 0, (83.8% identity in 302 aa overlap); and similar to other bacterial putative membrane proteins e.g. CAB89063|AL353872 putative integral membrane protein SC5G8.12 from Streptomyces coelicolor (322 aa), Fasta scores: E(): 0, (48.6% identity in 290 aa overlap); and NOEC_AZOCA|Q43967 possible integral membrane protein found near nod locus from Azorhizobium caulinodans noeC (307 aa), Fasta scores: E(): 1.1e-12, (31.4% identity in 191 aa overlap). Also similar to Q8NLQ9 4-hydroxybenzoate polyprenyltransferases from Corynebacterium glutamicum (332 aa), Fasta scores: E(): 0, (60.8% identity in 293 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Q9CDB5 No cell wall and cell processes PF01040 Q9CDB5 GO:0004659,GO:0016021 Rv3806c Rv3806c AL450380.2 Mycobrowser_v4 CDS 50656 51996 . + 0 ML0041 mycP1 Possible secreted protease ML0041, len: 446 aa. Possible secreted protease (EC 3.4.21.-), highly similar to Rv3883c|O05461|AL123456 Possible secreted protease from M. tuberculosis (446 aa), Fasta scores: E(): 0, (79.1% identity in 446 aa overlap). Shows weaker similarity to known bacterial proteases e.g. Q46541|L18984 acidic protease V5 from Bacteroides nodosus aprV5 (595 aa), Fasta scores: E(): 1.8e-07, (28.1% identity in 442 aa overlap). Also similar to ML1538 and ML2528 from M. leprae. Previously sequenced as O33076|Y14967 (446 aa), Fasta scores: E(): 0, (99.8% identity in 446 aa overlap). Contains a probable N-terminal signal sequence. Contains 2 Pfam matches to entry PF00082 Peptidase_S8, Subtilase family. Q7AQP4 No intermediary metabolism and respiration PF00082 Q7AQP4 GO:0004252,GO:0006508 Rv3883c Rv3883c AL450380.2 Mycobrowser_v4 CDS 68866 70587 . - 0 ML0055c eccA1 ESX CONSERVED COMPONENT ECCA1 ML0055c, len: 573 aa. esx conserved component, member of the CBXX/CFQX family of hypothetical proteins; C-terminal end is highly similar to many e.g. SP5K_BACSU|P27643 SpoVK/SpoVJ, stage V sporulation protein from Bacillus subtilis (322 aa), Fasta scores: E(): 3.5e-26, (33.7% identity in 332 aa overlap). Also highly similar to several M. tuberculosis hypothetical proteins e.g. Rv3868|Y2G8_MYCTU|O69733 hypothetical protein of the CBXX/CFQX family from M. tuberculosis (573 aa), Fasta scores: E(): 0, (89.2% identity in 573 aa overlap); and Rv0282. Previously sequenced as Y2G8_MYCLE|O33089 (573 aa), Fasta scores: E(): 0, (100.0% identity in 573 aa overlap). Similar to ML1536 and ML2537 from M. leprae. Shows weak similarity to ML0798. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). O33089 No cell wall and cell processes PF00004 O33089 GO:0017111,GO:0005524 Rv3868 Rv3868 AL450380.2 Mycobrowser_v4 CDS 3022091 3024013 . - 0 ML2537c eccA3 ESX CONSERVED COMPONENT ECCA3 ML2537c, len: 640 aa. esx conserved component, similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv0282 |Y282_MYCTU (O53687) fasta scores: E(): 0, 83.6% identity in 628 aa. The C-terminus is also similar to many CBXX/CFQX family proteins e.g. Alcaligenes eutrophus CBXP_ALCEU (Q04540) fasta scores: E(): 3.8e-24, 36.4% identity in 283 aa. Also similar to ML0055 and ML1536 from M. leprae. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CD28 No cell wall and cell processes PF00004 Q9CD28 GO:0017111,GO:0005524 Rv0282 Rv0282 AL450380.2 Mycobrowser_v4 CDS 1851736 1853568 . - 0 ML1536c eccA5 ESX CONSERVED COMPONENT ECCA5 ML1536c, len: 610 aa. esx conserved component, highly similar to several Mycobacterium tuberculosis proteins of undefined function e.g. Rv1798|YH98_MYCTU (O53947) (610 aa), Fasta scores: E(): 0, 89.7% identity in 609 aa overlap. The C-terminus of this protein is also similar to several including: Bacillus subtilis stage V sporulation protein K SP5K_BACSU (P27643) (322 aa), Fasta scores: E(): 2.2e-20, 34.5% identity in 310 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q9CBV5 No cell wall and cell processes PF00004 Q9CBV5 GO:0017111,GO:0005524 Rv1798 Rv1798 AL450380.2 Mycobrowser_v4 CDS 67417 68862 . - 0 ML0054c eccB1 ESX CONSERVED COMPONENT ECCB1. POSSIBLE MEMBRANE PROTEIN. ML0054c, len: 481 aa. esx conserved component, possible membrane protein, highly similar to several M. tuberculosis hypothetical proteins e.g. Rv3869|O69734|AL123456 conserved membrane protein (480 aa), Fasta scores: E(): 0, (75.7% identity in 478 aa overlap). Similar to ML1544 and ML2536 from M. leprae. Previously sequenced as O33088|Y14967 (481 aa), Fasta scores: E(): 0, (100.0% identity in 481 aa overlap). Contains hydrophobic, possible membrane-spanning region near the N-terminus. Q7AQN9 No cell wall and cell processes PF05108 Q7AQN9 Rv3869 Rv3869 AL450380.2 Mycobrowser_v4 CDS 3020440 3022098 . - 0 ML2536c eccB3 ESX CONSERVED COMPONENT ECCB3. POSSIBLE MEMBRANE PROTEIN. ML2536c, len: 552 aa. esx conserved component, possible membrane protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0283 TR:O53688 (EMBL:AL021930) fasta scores: E(): 0, 70.8% identity in 552 aa. Also similar to ML1544 from M. leprae. Contains a possible membrane spanning hydrophobic domain. Q9CD29 No cell wall and cell processes PF05108 Q9CD29 Rv0283 Rv0283 AL450380.2 Mycobrowser_v4 CDS 1866375 1867895 . - 0 ML1544c eccB5 ESX CONSERVED COMPONENT ECCB5. POSSIBLE MEMBRANE PROTEIN. ML1544c, len: 506 aa. esx conserved component, probable membrane protein. Highly similar to many Mycobacterium tuberculosis proteins of unknown function including:Rv1782 TR:O53933 (EMBL:AL022021) (506 aa), Fasta scores: E(): 0, 82.6% identity in 506 aa overlap. Also similar to ML0054 from M. leprae. Contains a possible membrane spanning hydrophobic domain. Q7AQ46 No cell wall and cell processes PF05108 Q7AQ46 Rv1782 Rv1782 AL450380.2 Mycobrowser_v4 CDS 65186 67420 . - 0 ML0053c eccCa1 ESX CONSERVED COMPONENT ECCCA1. POSSIBLE TRANSMEMBRANE PROTEIN. ML0053c, len: 744 aa. esx conserved component, possible transmembrane protein, highly similar to Rv3870|O69735|AL123456 conserved transmembrane protein from M. tuberculosis (747 aa), Fasta scores: E(): 0, (85.4% identity in 746 aa overlap). Show some similarity with the N-terminal part of several proteins while the downstream ML0052 is similar to the corresponding C-terminal part e.g. O86653|AL031231 putative ATP/GTP-binding proteins from Streptomyces coelicolor (1321 aa), Fasta scores: E(): 0, (34.7% identity in 760 aa overlap); Rv3447c|O06264|AL123456 unknown membrane protein from M. tuberculosis (1236 aa), Fasta scores: E(): 0, (37.2% identity in 732 aa overlap); and Rv1784. Related proteins are also found in Bacillus spp. Similar to the N-terminal halves of ML1543 and ML2535. Contains hydrophobic, possible membrane-spanning region near the N-terminus. Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Q7AQP0 No cell wall and cell processes PF01580 Q7AQP0 GO:0003677,GO:0007049,GO:0051301,GO:0007059,GO:0016021,GO:0005524 Rv3870 Rv3870 AL450380.2 Mycobrowser_v4 CDS 63319 65112 . - 0 ML0052c eccCb1 ESX CONSERVED COMPONENT ECCCB1 ML0052c, len: 597 aa. esx conserved component, highly similar to Rv3871|O69736|AL123456 conserved hypothetical protein from M. tuberculosis (591 aa), Fasta scores: E(): 0, (80.9% identity in 596 aa overlap). Show some similarity with the C-terminal part of several proteins while the upstream ML0053 is similar to the corresponding N-terminal part e.g. O86653|AL031231 putative ATP/GTP-binding proteins from Streptomyces coelicolor (1321 aa), Fasta scores: E(): 0, (34.7% identity in 574 aa overlap); Rv3447c|O06264|AL123456 unknown membrane protein from M. tuberculosis (1236 aa), Fasta scores: E(): 0, (35.2% identity in 588 aa overlap); and Rv1784. Related proteins are also found in Bacillus spp. Similar to the C-terminal halves of ML1543 and ML2535. Previously sequenced as O33086|Y14967 (597 aa), Fasta scores: E(): 0, (99.7% identity in 597 aa overlap). Contains 2 Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Q9CDD7 No cell wall and cell processes PF01580 Q9CDD7 GO:0003677,GO:0007049,GO:0051301,GO:0007059,GO:0016021,GO:0017111,GO:0005524 Rv3871 Rv3871 AL450380.2 Mycobrowser_v4 CDS 3016454 3020443 . - 0 ML2535c eccC3 ESX CONSERVED COMPONENT ECCC3. POSSIBLE MEMBRANE PROTEIN. ML2535c, len: 1329 aa. esx conserved component, possible membrane protein. Similar to Mycobacterium tuberculosis hypothetical protein Rv0284 TR:O53689 (EMBL:AL021930) fasta scores: E(): 0, 84.2% identity in 1318 aa and to Streptomyces coelicolor ATP/GTP binding protein SC3C3.20C TR:O86653 (EMBL:AL031231) fasta scores: E(): 0, 36.0% identity in 1379 aa. Also similar in regions to several cell division proteins e.g. Coxiella burnetii cell division protein, FtsK homologue, FTSK_COXBU (P39920) E(): 4.2e-07 28.3% identity in 304. And similar to ML0053 from M. leprae. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 3 x PS00017 ATP/GTP-binding site motif A (P-loop). Q9CD30 No cell wall and cell processes PF01580 Q9CD30 GO:0003677,GO:0007049,GO:0051301,GO:0007059,GO:0016021,GO:0017111,GO:0005524 Rv0284 Rv0284 AL450380.2 Mycobrowser_v4 CDS 1862221 1866378 . - 0 ML1543c eccC5 ESX CONSERVED COMPONENT ECCC5. PROBABLE MEMBRANE PROTEIN (SpoIIIE FAMILY) ML1543c, len: 1385 aa. esx conserved component, probable membrane protein (SpoIIIE-family). Highly similar to the C-terminus of Rv1784 hypothetical protein TR:O53935 (EMBL:AL022021) (932 aa), Fasta scores: E(): 0, 87.8% identity in 932 aa overlap. The N-terminus is similar to Rv1783 conserved membrane protein TR:O53934 (EMBL:AL022021) (435 aa), Fasta scores: E(): 0, 87.1% identity in 395 aa overlap. The C-terminus is also similar to several others e.g. Bacillus subtilis SP3E_BACSU (P21458) (787 aa), Fasta scores: E(): 3e-09, 24.0% identity in 391 aa overlap stage III sporulation protein E (SpoIIIE) a protein required for chromosome segregation. Also similar to ML2535 from M. leprae. Contains possible N-terminal membrane spanning hydrophobic domains. Contains 2 Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Q7AQ47 No cell wall and cell processes PF01580 Q7AQ47 GO:0003677,GO:0007049,GO:0051301,GO:0007059,GO:0016021,GO:0017111,GO:0005524 Rv1784,Rv1783 Rv1784,Rv1783 AL450380.2 Mycobrowser_v4 CDS 1856526 1858037 . - 0 ML1539c eccD5 ESX CONSERVED COMPONENT ECCD5. PROBABLE MEMBRANE PROTEIN. ML1539c, len: 503 aa. esc conserved component, hypothetical membrane protein. Similar to several Mycobacterium tuberculosis proteins of undefined function e.g. putative membrane protein Rv1795 TR:O53944 (EMBL:AL022021) (503 aa), Fasta scores: 76.9% identity in 503 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Q9CBV2 No cell wall and cell processes PF04600 Q9CBV2 Rv1795 Rv1795 AL450380.2 Mycobrowser_v4 CDS 1871964 1872647 . - 0 ML1547c pptT probable phosphopantetheinyl transferase, by homology with phosphopantetheinyl transferase pptT(Rv2794c) from M. tuberculosis H37Rv ML1547c, len: 227 aa. Highly similar to phosphopantetheinyl transferase pptT from Mycobacterium tuberculosis Rv2794c (227 aa), Fasta scores: E(): 0, 79.7% identity in 227 aa overlap. Weakly similar to a number of proteins essential for the production of iron chelators e.g. Escherichia coli enterobactin synthetase component D SW:ENTD_ECOLI (P19925) (209 aa), Fasta scores: E(): 0.002, 29.4% identity in 177 aa overlap. Also similar to Streptomyces sp. L-proline 3-hydroxylase TR:O24813 (EMBL:AB007189) (208 aa), Fasta scores: E(): 0, 50.7% identity in 209 aa overlap Q7AQ45 No lipid metabolism PF01648 Q7AQ45 GO:0009366,GO:0008897,GO:0009059,GO:0000287,GO:0009239 Rv2794c Rv2794c AL450380.2 Mycobrowser_v4 CDS 3118774 3120777 . - 0 ML2613c zmp1 probable zinc metalloprotease ML2613c, len: 667 aa. Probable zinc metalloprotease (EC 3.4.24.-). Similar to Mycobacterium tuberculosis zinc metalloprotease Rv0198c TR:O53649 (EMBL:AL021928) fasta scores: E(): 0, 80.8% identity in 667 aa. Also similar to many Eukaryotic metalloproteases denoted endothelin-converting enzymes e.g. Homo sapiens ECE1 SW:ECE1_HUMAN (P42892) fasta scores: E(): 0, 32.6% identity in 685 aa. Contains Pfam match to entry PF01431 Peptidase_M13, Peptidase family M13. Contains PS00142 Neutral zinc metallopeptidases. Q7APT3 No intermediary metabolism and respiration PF01431,PF05649 Q7APT3 GO:0004222,GO:0006508,GO:0016020 Rv0198c Rv0198c AL450380.2 Mycobrowser_v4 CDS 297941 298516 . + 0 ML0226 folK Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase) ML0226, len: 191 aa. Probable folK, 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase (EC 2.7.6.3), highly similar to Rv3606c|HPPK_MYCTU|O06276 folK, 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase from M. tuberculosis (188 aa), Fasta scores: E(): 0, (63.2% identity in 190 aa overlap). Similar to many others e.g. to the C-terminal half of SULD_STRPN|P22291 sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase) from Streptococcus pneumoniae (270 aa), Fasta scores: E(): 1.8e-07, (37.8% identity in 135 aa overlap). Previously sequenced as HPPK_MYCLE|O69528 (191 aa), Fasta scores: E(): 0, (100.0% identity in 191 aa overlap). Contains Pfam match to entry PF01288 HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Contains PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. Belongs to the HPPK family. O69528 No intermediary metabolism and respiration PF01288 O69528 GO:0005524,GO:0046656,GO:0016301,GO:0003848 2.7.6.3 Rv3606c Rv3606c AL450380.2 Mycobrowser_v4 CDS 648423 649550 . + 0 ML0535 carA Probable carbamoyl-phosphate synthase small chain CarA (Carbamoyl- phosphate synthetase glutamine chain). SUBUNIT: COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE. Belongs to the CarA family. ML0535, len: 375 aa. Probable carA, Carbamoyl-phosphate synthase small chain (EC 6.3.5.5), highly similar to P71811|AL123456|Rv1383 carA, carbamoyl-phosphate synthase subunit from M. tuberculosis (376 aa), Fasta scores: E(): 0, (85.4% identity in 377 aa overlap); and CAD94279|Mb1418 from M. bovis (376 aa). Similar to many e.g. CARA_ECOLI|P00907 carA, carbamoyl-phosphate synthase subunit from Escherichia coli (382 aa), Fasta scores: E(): 0, (43.2% identity in 389 aa overlap). Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. Q9CCR3 No intermediary metabolism and respiration PF00117,PF00988 Q9CCR3 GO:0006526,GO:0004088,GO:0006541,GO:0006221,GO:0005524 6.3.5.5 Rv1383 Rv1383 AL450380.2 Mycobrowser_v4 CDS 1484292 1486031 . + 0 ML1245 plsC C-TERMINUS: INVOLVED IN PHOSPHOLIPID BIOSYNTHESIS (AT THE SECOND STEP); CONVERTS LYSOPHOSPHATIDIC ACID (LPA) INTO PHOSPHATIDIC ACID BY INCORPORATING ACYL MOIETY AT THE 2 POSITION [CATALYTIC ACTIVITY 2: ACYL-CoA + 1-ACYL-SN-GLYCEROL 3-PHOSPHATE = CoA + 1,2-DIACYL-SN-GLYCEROL 3-PHOSPHATE]. N-TERMINUS: COULD BE GENERATE SERINE AND PHOSPHATE FROM PHOSPHOSERINE; MAY CATALYZE THE LAST STEP IN THE BIOSYNTHESIS OF SERINE FROM CARBOHYDRATES (THE REACTION MECHANISM COULD BE PROCEED VIA THE FORMATION OF A PHOSPHORYL-ENZYME INTERMEDIATES) [CATALYTIC ACTIVITY 1: PHOSPHOSERINE + H(2)O = SERINE + PHOSPHATE]. POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSP) (PSPASE) + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE) (LPAAT) ML1245, len: 579 aa. Possible plsC, a transmembrane phospholipid biosynthesis bifunctional enzyme, including L-3-phosphoserine phosphatase (EC 3.1.3.3) and 1-acyl-Sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51). The N-terminus is similar to several phosphoserine phosphatases e.g. Haemophilus influenzae SW:SERB_HAEIN (P44997) (795 aa), BlastP Expect 9.8 and the C-terminus is similar to many Prokaryotic and Eukaryotic acyltransferases e.g. Salmonella typhimurium 1-acyl-SN-glycerol-3-phosphate acyltransferase SW:PLSC_SALTY (P26974) (245 aa), Fasta scores: E(): 1.4e-11, 35.3% identity in 167 aa overlap. Highly similar over entire protein to Mycobacterium tuberculosis putative transferase Rv2483c TR:O53208 (EMBL:AL021246) (580 aa), Fasta scores: E(): 0, 77.1% identity in 573 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. Q7AQ81 No lipid metabolism PF01553 Q7AQ81 GO:0008152,GO:0016791,GO:0008415 Rv2483c Rv2483c AL450380.2 Mycobrowser_v4 CDS 2677270 2678766 . + 0 ML2254 otsA INVOLVED IN OSMOREGULATORY TREHALOSE BIOSYNTHESIS. Mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [CATALYTIC ACTIVITY: UDP-GLUCOSE + D-GLUCOSE 6-PHOSPHATE = UDP + ALPHA,ALPHA-TREHALOSE 6-PHOSPHATE]. PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] OTSA (TREHALOSE-6-PHOSPHATE SYNTHASE) (UDP-GLUCOSE-GLUCOSEPHOSPHATE GLUCOSYLTRANSFERASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYLTRANSFERASE) (TREHALOSE-6-PHOSPHATE SYNTHETASE) (TREHALOSE-PHOSPHATE SYNTHASE) (TREHALOSE-PHOSPHATE SYNTHETASE) (TRANSGLUCOSYLASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYL TRANSFERASE) ML2254, len: 498 aa. Probable otsA, trehalose-phosphate synthase (EC 2.4.1.15). Similar to Mycobacterium tuberculosis otsA or Rv3490 or MTCY13E12.43 TR:O06353 (EMBL:Z95390) (500 aa) fasta scores: E(): 0, 80.3% identity in 497 aa. Similar to Candida albicans alpha,alpha-trehalose-phosphate synthase [UDP-forming] tps1 SW:TPS1_CANAL (Q92410) (478 aa) fasta scores: E(): 0, 37.8% identity in 473 aa. Previously sequenced as TR:Q50167 (EMBL:U15187). Contains Pfam match to entry PF00982 TrehaloseP_syn, Trehalose-6-phosphate synthase domain. Q50167 No virulence, detoxification, adaptation PF00982 Q50167 GO:0005992,GO:0016757 2.4.1.- Rv3490 Rv3490