Gene ML0001
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (DNAA BOX): 5'-TTATC(C/A)A(C/A)A-3'. DNAA binds to ATP and to acidic phospholipids. |
| Product | Probable chromosomal replication initiator protein DnaA |
| Comments | ML0001, len: 521 aa. Probable dnaA, chromosomal replication initiator protein (see citations below), highly similar to other Mycobacterial chromosomal replication initiator proteins e.g. Rv0001|DNAA_MYCTU|P49993 from M. tuberculosis (507 aa), Fasta scores: E(): 0, (87.2% identity in 507 aa overlap); and DNAA_MYCSM|P49992 from M. smegmatis (495 aa), Fasta scores: E(): 0, (69.2% identity in 441 aa overlap). Previously sequenced as DNAA_MYCLE|P46388 (521 aa), Fasta scores: E(): 0, (99.8% identity in 521 aa overlap). Contains Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA protein. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS01008 DnaA protein signature. Belongs to the DnaA family. Note that the first base of this gene has been taken as base 1 of the Mycobacterium leprae genomic sequence. |
| Functional category | Information pathways |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1 | 1566 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0001|dnaA
MFVPHAKKPEIYENQRDTSLADDLSLGFTTVWNAVVSELNGESNTDDEATNDSTLVTPLTPQQRAWLNLVQPLTIIEGFALLSVPSSFVQNEIERHLRTPITDALSRRLGQQIQLGVRIAPPSTDHIDDNSSSADVLLTDDCGTDTDENYGEPLTGEYQGLPTYFTERPHHTESTVTGGTSLNRRYTFETFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMERLAVPGDVLELIASSIERNIRELEGALIRVTAFASLNKTAIDKALAEIVLRDLIADASTMQISAATIMTATAEYFDTTIEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR
Bibliography
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