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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionPlays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (DNAA BOX): 5'-TTATC(C/A)A(C/A)A-3'. DNAA binds to ATP and to acidic phospholipids.
ProductProbable chromosomal replication initiator protein DnaA
CommentsML0001, len: 521 aa. Probable dnaA, chromosomal replication initiator protein (see citations below), highly similar to other Mycobacterial chromosomal replication initiator proteins e.g. Rv0001|DNAA_MYCTU|P49993 from M. tuberculosis (507 aa), Fasta scores: E(): 0, (87.2% identity in 507 aa overlap); and DNAA_MYCSM|P49992 from M. smegmatis (495 aa), Fasta scores: E(): 0, (69.2% identity in 441 aa overlap). Previously sequenced as DNAA_MYCLE|P46388 (521 aa), Fasta scores: E(): 0, (99.8% identity in 521 aa overlap). Contains Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA protein. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS01008 DnaA protein signature. Belongs to the DnaA family. Note that the first base of this gene has been taken as base 1 of the Mycobacterium leprae genomic sequence.
Functional categoryInformation pathways
Coordinates
TypeStartEndOrientation
CDS11566+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0001|dnaA
MFVPHAKKPEIYENQRDTSLADDLSLGFTTVWNAVVSELNGESNTDDEATNDSTLVTPLTPQQRAWLNLVQPLTIIEGFALLSVPSSFVQNEIERHLRTPITDALSRRLGQQIQLGVRIAPPSTDHIDDNSSSADVLLTDDCGTDTDENYGEPLTGEYQGLPTYFTERPHHTESTVTGGTSLNRRYTFETFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMERLAVPGDVLELIASSIERNIRELEGALIRVTAFASLNKTAIDKALAEIVLRDLIADASTMQISAATIMTATAEYFDTTIEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR
      
Bibliography
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