Gene ML0016c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) |
| Comments | ML0016c, len: 622 aa. Probable pknB, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to Rv0014c|PKNB_MYCTU|P71584 pknB, transmembrane serine/threonine protein kinase from M. tuberculosis (626 aa), Fasta scores: E(): 0, (86.3% identity in 626 aa overlap); and similar to Q9ZFS8|AF094711 pksC, serine/threonine protein kinase from Streptomyces coelicolor (556 aa), Fasta scores: E(): 0, (47.8% identity in 297 aa overlap). Also similar to ML0017 and ML0897 and to part of ML0304 from M. leprae. Previously sequenced as PKNB_MYCLE|P54744 (622 aa), Fasta scores: E(): 0, (99.7% identity in 622 aa overlap). Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains PS00107 Protein kinases ATP-binding region signature. |
| Functional category | Regulatory proteins |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 19001 | 20869 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0016c|pknB
MTTPPHLSDRYELGDILGFGGMSEVHLARDIRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPSIVAVYDTGEAETSAGPLPYIVMEYVDGATLRDIVHTDGPMPPQQAIEIVADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSTSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPPFIGDSPVSVAYQHVREDPIPPSQRHEGISVDLDAVVLKALAKNPENRYQTAAEMRADLIRVHSGQPPEAPKVLTDADRSCLLSSGAGNFGVPRTDALSRQSLDETESDGSIGRWVAVVAVLAVLTIAIVAAFNTFGGNTRDVQVPDVRGQVSADAISALQNRGFKTRTLQKPDSTIPPDHVISTEPGANASVGAGDEITINVSTGPEQREVPDVSSLNYTDAVKKLTSSGFKSFKQANSPSTPELLGKVIGTNPSANQTSAITNVITIIVGSGPETKQIPDVTGQIVEIAQKNLNVYGFTKFSQASVDSPRPTGEVIGTNPPKDATVPVDSVIELQVSKGNQFVMPDLSGMFWADAEPRLRALGWTGVLDKGPDVDAGGSQHNRVAYQNPPAGAGVNRDGIITLKFGQ
Bibliography
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