Gene ML0017c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepknA
Gene length1314 bp
IdentifierML0017c
Location 20879 bp
Protein summary information
Molecular mass46311.8 Da
Isoelectric point10.33
Protein length438 amino acids
Structural information
PFAMPF00069
Orthologs
M. tuberculosis H37RvRv0015c
M. lepromatosis Mx1-22AMLPM_0017
Cross-references
UniProtP54743
Gene OntologyProtein phosphorylation, Protein serine/threonine kinase activity, Atp binding
Enzyme Classification2.7.11.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionInvolved in signal transduction (via phosphorylation). Thought to regulate morphological changes asociated with cell division/differentiation process. Phosphorylates at serine and threonine residues [catalytic activity: ATP + A Protein = ADP + A Phosphoprotein].
ProductProbable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)
CommentsML0017c, len: 437 aa. Probable pknA, transmembrane serine/threonine-protein kinase (EC 2.7.1.-), possibly magnesium/manganese dependent (see citations below), highly similar to Rv0015c|PKNA_MYCTU|P71585 pknA, serine/threonine protein kinase from M. tuberculosis (431 aa), Fasta scores: E(): 0, (81.0% identity in 431 aa overlap) and some similarity to Q9ZFS8|AF094711 pksC, serine/threonine protein kinase from Streptomyces coelicolor (556 aa), Fasta scores: E(): 2.1e-29, (39.9% identity in 346 aa overlap). Also similar to ML0016 and ML0897 and to part of ML0304 from M. leprae. Previously sequenced as PKNA_MYCLE|P54743 (437 aa), Fasta scores: E(): 0, (84.6% identity in 448 aa overlap). Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature.
Functional categoryRegulatory proteins
Coordinates
TypeStartEndOrientation
CDS2087922192-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0017c|pknA
MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKVLKGEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDATPASDVYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKEPPPPLPADLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPPRPNQTPSSGRASPTTIPSSTQARAAVACGTKTPAPRRSRPSTSGNRPPPARNTFSSGQRALLWAAGMLGALAIIIAVLIVINSYAGNEQHQPPTPTVTDTGTPPATKTLSGFPAAYCEYRVNWTNHKEISNSGLPKQAARAQLAGATDISPVAGQT
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