Gene ML0048c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameespI
Gene length1761 bp
IdentifierML0048c
Location 59555 bp
Protein summary information
Molecular mass63226.2 Da
Isoelectric point7.33
Protein length587 amino acids
Orthologs
M. tuberculosis H37RvRv3876
M. lepromatosis Mx1-22AMLPM_0048
Cross-references
UniProtQ9CDD8
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductESX-1 SECRETION-ASSOCIATED PROTEIN ESPI. CONSERVED PROLINE AND ALANINE RICH PROTEIN.
CommentsML0048c, len: 586 aa. ESX-1 secretion-associated protein, conserved pro-, ala-rich protein. Similar to several proteins from M. tuberculosis, some of which also contain proline-rich regions e.g. Rv3876|O69740|AL123456 pro-, ala-rich protein (666 aa), Fasta scores: (50.7% identity in 672 aa overlap); and Rv0530|O06396|AL123456 hypothetical protein (405 aa), Fasta scores: E(): 1.3e-19, (30.5% identity in 417 aa overlap). Similar to the C-terminal half of O86637|AL031231 hypothetical protein SC3C3.03C from Streptomyces coelicolor (1083 aa), Fasta scores: E(): 5.9e-27, (31.6% identity in 580 aa overlap), which contains Pro-Gln repeats. C-terminal half is similar to that of ML0798. Previously sequenced as O33082|Y14967 (478 aa), Fasta scores: (100.0% identity in 478 aa overlap).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS5955561315-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0048c|espI
MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEVASPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAPPRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATPMPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRPSANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAEPAPTQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAKRGWRHWVHTVTRINLGLSPDERYELDLRTRVRRPPRGSYQIGILGLKGGAGKTTVTVTLGSMFARVRNDRILVVDADTSCGNLADRAGRFSEANIADLLADKDVKSYNDIRTHTSVNAVNLEVLPAAEYSTAQHALSGEDWNFAAATVSKYYNVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSVDAARQAAIALDWLRHNGYQDLLSRACVVINHVMPKEPNIASKDLVQQFEQQIQPGRVVVLPWDKHIAAGTEIRLDRLDPLYRRRILELAAALSDDFERAGRH
Bibliography