Gene ML0049c (esat-6) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameesxA
Gene length288 bp
IdentifierML0049c
Location 61406 bp
Protein summary information
Molecular mass10464.5 Da
Isoelectric point4.93
Protein length96 amino acids
Structural information
PFAMPF06013
Orthologs
M. tuberculosis H37RvRv3875
M. lepromatosis Mx1-22AMLPM_0049
Cross-references
UniProtQ50206
Gene OntologyExtracellular region
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable 6 kDa early secretory antigenic target homolog EsxA (ESAT-6-like protein) (L-ESAT)
CommentsML0049c, len: 95 aa. Probable esxA, 6 KDa early secretory antigenic target homolog (see citations below). Similar to Rv3875|ESA6_MYCTU|Q57165 esxA, early secretory antigenic target from M. tuberculosis (94 aa), Fasta scores: E(): 4.2e-10, (36.3% identity in 91 aa overlap). Also shows weak similarity to others e.g. CFP7_MYCTU|O53693 esxH, 10 KDa antigen from M. tuberculosis (95 aa), Fasta scores: E(): 0.17, (25.6% identity in 78 aa overlap). Other members of this family include ML0363. Previously sequenced as ESA6_MYCLE|Q50206 (95 aa), Fasta scores: E(): 0, (100.0% identity in 95 aa overlap). Belongs to the ESAT6 family. Note that previously known as esat-6.
Functional categoryCell wall and cell processes
Coordinates
TypeStartEndOrientation
CDS6140661693-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0049c|esxA
MIQAWHFPALQGAVNELQGSQSRIDALLEQCQESLTKLQSSWHGSGNESYSSVQRRFNQNTEGINHALGDLVQAINHSAETMQQTEAGVMSMFTG
Bibliography
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