Gene ML0064c (aka, etaR)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable transcriptional regulatory repressor protein (TetR-family) EthR |
| Comments | ML0064c, len: 214 aa. Probable ethR (alternate gene names: aka, etaR), regulatory protein tetR family, involved in ethionamide sensitivity/resistance. Probably negatively controls neighbouring ethA (ML0065, alternate gene names: aka etaA) (see citations below). Highly similar to Rv3855|P96222|Al123456 ethR, regulatory protein tetR family protein from M. tuberculosis (216 aa), Fasta scores: E(): 0, (77.0% identity in 213 aa overlap). Also some similarity to other transcriptional regulators e.g. Q9S1R1 putative tetR-family transcriptional regulator from Streptomyces coelicolor A3 (204 aa), Fasta scores: E(): 0, (29.1% identity in 196 aa overlap). And similar to ML1070 from M. leprae. Contains a probable helix-turn-helix motif at aa 45-66 (Score 1261, SD +3.48) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Belongs to the TetR/AcrR family of transcriptional regulators. |
| Functional category | Regulatory proteins |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 85968 | 86612 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0064c|ethR
VINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYLAKSAGISRPTFYFYFASKEAVLLTLLDRVFNKANAALETLIKNRDNKRGNKWRTGINVFFETFGSHKAVTCAGQVTRDNTEVRKLWSTFMQKWISYTAAVIDAERKRGVAPDTLPATELATALNLMNERALFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR
Bibliography
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