Gene ML0065 (aka, etaA)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable monooxygenase EthA |
| Comments | ML0065, len: 494 aa. Probable ethA (alternate gene names: aka, etaA), monooxygenase required for activation of the pro-drug ethionamide (EC 1.-.-.-) (see citations below), highly similar to other M. tuberculosis monooxygenases e.g. Rv3854c|P96223|AL123456 ethA, monooxygenase (489 aa), Fasta scores: E(): 0, (80.1% identity in 488 aa overlap); and Rv0892 and Rv1393c. Also similar to the C-terminal half of Q9RZT0|AE001826 putative arylesterase/monoxygenase from Deinococcus radiodurans (833 aa), Fasta scores: E(): 0, (51.5% identity in 480 aa overlap). Shows weaker similarity to O50641|AB010439 steroid monooxygenase from Rhodococcus rhodochrous (549 aa), Fasta scores: E(): 2e-15, (24.9% identity in 469 aa overlap). Also similar to pseudogene ML1732. Contains Pfam match to entry PF00743 FMO-like, Flavin-binding monooxygenase-like. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 86681 | 88165 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0065|ethA
MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV
Bibliography
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