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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductProbable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)
CommentsML0100, len: 635 aa. Probable fadD32, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to several probable fatty-acid-CoA synthases from M. tuberculosis e.g. Rv3801c|O53580|AL123456 fadD32 (637 aa), Fasta scores: E(): 0, (93.2% identity in 632 aa overlap). Also similar to P71495|U75685 acyl-CoA synthase from Mycobacterium bovis BCG ORF3 (582 aa), Fasta scores: E(): 0, (36.8% identity in 581 aa overlap); and to domains of polyketide synthases e.g. Q50857|U24657 safB, saframycin Mx1 synthetase B from Myxococcus xanthus (1770 aa), Fasta scores: E(): 0, (36.4% identity in 605 aa overlap). And similar to ML0132, ML0138, ML1234 and ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme.
Functional categoryLipid metabolism
Coordinates
TypeStartEndOrientation
CDS124599126506+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0100|fadD32
VTGEGRMAYHNPFIVNGKIRFPPNTNLVRHVEKWAKVRGDKLAYRFLDFSTGRDGVARDILWSEFSARNRAVGARLQQVTQPGDRIAILCPQNLDYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCTPSTILTTTDSAEGVRKFIRGRFAKERTRVIAVDAVPNEVAATWQQPEANEETVAYLQYTSGSTRIPSGVQITHLNLPTNVLQVLNSLQGQEGDRGVSWLPFFHDMGLITVLLPSVLGHSFTFMTPAAFVRRPGRWIRELARKPEDTGGTFSAAPNFAFEHAAMRGLPRDDELPLDLSNVKGILNGSEPVSPASMRKFFEAFAPYGLKQTAVKPSYGLAEATLFVSTTPMDESPTVIHVDRYELNNQRFVEVPADAPNAVAQVSAGKVGVSEWAIIVDADTASELPDGQIGEIWLHGNNLGTGYWGKEEESAQTFNNILKSRISESRAEGASDDASWVRTGDYGTYFKDHLYIAGRIKDLVIIDGRNHYPQDLEYTAQESTKALRVGYVAAFSVPANQLAQVVLEDPHVGLKFDAEDTSEQLVIVGERAAGTHKLDYQPIVDDIRAAIAVRHGVAVRDVLLVPAGTIPRTSSGKIGRRACRAAYIDGSLRSGASSPTVFAAEF
      
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