Gene ML0100
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) |
| Comments | ML0100, len: 635 aa. Probable fadD32, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to several probable fatty-acid-CoA synthases from M. tuberculosis e.g. Rv3801c|O53580|AL123456 fadD32 (637 aa), Fasta scores: E(): 0, (93.2% identity in 632 aa overlap). Also similar to P71495|U75685 acyl-CoA synthase from Mycobacterium bovis BCG ORF3 (582 aa), Fasta scores: E(): 0, (36.8% identity in 581 aa overlap); and to domains of polyketide synthases e.g. Q50857|U24657 safB, saframycin Mx1 synthetase B from Myxococcus xanthus (1770 aa), Fasta scores: E(): 0, (36.4% identity in 605 aa overlap). And similar to ML0132, ML0138, ML1234 and ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. |
| Functional category | Lipid metabolism |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 124599 | 126506 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0100|fadD32
VTGEGRMAYHNPFIVNGKIRFPPNTNLVRHVEKWAKVRGDKLAYRFLDFSTGRDGVARDILWSEFSARNRAVGARLQQVTQPGDRIAILCPQNLDYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCTPSTILTTTDSAEGVRKFIRGRFAKERTRVIAVDAVPNEVAATWQQPEANEETVAYLQYTSGSTRIPSGVQITHLNLPTNVLQVLNSLQGQEGDRGVSWLPFFHDMGLITVLLPSVLGHSFTFMTPAAFVRRPGRWIRELARKPEDTGGTFSAAPNFAFEHAAMRGLPRDDELPLDLSNVKGILNGSEPVSPASMRKFFEAFAPYGLKQTAVKPSYGLAEATLFVSTTPMDESPTVIHVDRYELNNQRFVEVPADAPNAVAQVSAGKVGVSEWAIIVDADTASELPDGQIGEIWLHGNNLGTGYWGKEEESAQTFNNILKSRISESRAEGASDDASWVRTGDYGTYFKDHLYIAGRIKDLVIIDGRNHYPQDLEYTAQESTKALRVGYVAAFSVPANQLAQVVLEDPHVGLKFDAEDTSEQLVIVGERAAGTHKLDYQPIVDDIRAAIAVRHGVAVRDVLLVPAGTIPRTSSGKIGRRACRAAYIDGSLRSGASSPTVFAAEF
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