Gene ML0101
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Polyketide synthase Pks13 |
| Comments | ML0101, len: 1784 aa. Probable pks13, polyketide synthase (EC undetermined), similar to many polyketide synthases from M. tuberculosis e.g. Rv3800c|O53579 pks13, polyketide synthase (1733 aa), Fasta scores: E(): 0, (83.6% identity in 1748 aa overlap); and PPSA_MYCTU|Q10977 ppsA, phenolpthiocerol synthesis polyketide synthase (1876 aa), Fasta scores: E(): 0, (36.1% identity in 1277 aa overlap). Similar to many others e.g. AAF71766|AF263912 nystatin biosynthesis polyketide synthase from Streptomyces noursei nysI (9477 aa), Fasta scores: E(): 0, (33.4% identity in 1215 aa overlap). Also similar to ML0135, ML0139, ML1229, ML2353, ML2354, ML2355, ML2356, and ML2357 from M. leprae. Similar to ML2607c a possible pseudogene similar to M. tuberculosis pks13. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00975 Thioesterase, Thioesterase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. |
| Functional category | Lipid metabolism |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 126518 | 131872 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0101|pks13
MADVDAPQLNQDPPQLNQDPQANLPAEKTKMRFGDDAERSDEEVRRITRITTVPEMRQWLRNWVGKVVGKSPDDIDESAPMVELGLASRDAVAMAADIEDLTGVTLSVAVAFQYPTIESLANRIIEGESETIDDDTDAFDWSRTGSAERIDIAVVGLSTRLPGDMNSPEETWRALLEGRDAITDLPAGRWSEFLGEPRLAQRIAQARTRGGYLKDIKGFDSDFFAVAKTEAENIDPQQRMALELTWEALEHARIPASSLRGEAVGVYIGSSTNDYSFLAVSDPTIAHPYAITGTSSSIIANRVSYFYDFRGPSVTIDTACSSSLVAIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGSVLAPDGRIKSFSSDADGYTRSEGGGVLVLKRVNDARRDGDQILAVIAGSAVNHDGRSNGLIAPNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTVLGDPIEAEALGRVVGRGRPADRPALLGAVKTNVGHLESAAGAASMVKVVLALQHDKLPPSINFAGPSPYIDFDAMRLKVIDTATDWPRYGGYALAGVSSFGFGGANAHLVVREVLPRDVIEPERQPESPVPAAATTETAMLEGRVLRFDECGEIITDVADFGESEPELPGMTDEALQLKQAALEALAVKQVTAPLIPLVVSSFLTSRKKAAAAELADWMDSPQGRASSLESIGRSLSRRNHGRSRAVVLAHYHDEAIEGFRAIAEGKQRPHVFSVDGPVTNGPVWVFAGFGAQHREMGKSLYLRNQVFAEWIEKVDALVQDERGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLKHHGAKPAAVVGQSLGEAACAYFVGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIKTVFSDFPDLEVCVYAAPTQIVIGGPPEQVDAIIARAKAEGKFARKFATKGASHTQQMDPLLGELAAELQGIKPMSPTAGIYSTVHEGSYIKPGSDPIHDVDYWKKGLRHSVHFTQGIRNAVDNGHTTFLELAPNAVALMQVGLTTAAVGLHDAQLIPTLSRNQDEVESMISTMAQLYVYGHDLDIWTLFSRAVGPEDYADIPPTRFKRKEHWLDVHFAGDGSVSMPGNHVALPDSRHVWEFAPRDKTDLAALVRAAVSQVLPGAHLTAAEQRAMPGAGARLVTMLTRHPGGASVQVHARIDESFTLVYDALVARGGQESVLPTAVGAGTAIASITVPADAVTVAAEESDAEILSDSLTNRYLPSDMGKWSPDSGETIGHRLSTIVAAAMGYEPEDLPWEVPLVELGLDSLMAVRIKNRVEYDFDLPPIQLQAVRDANLYNVEKLIEYAIKHRDDVEQLHEYQKTQTAAAIAKAQMELLSGVSPVTLPASEAPIPPPPTDPTDPPSNGVQPNLVAAAEALTSEAVAKVLNSDVPPRDAAERVTFAAWAIVTGKSPGGIFDTLPKLDGDTAAKMAQRLSERAEGTITAEDVLTSENIEALAGKVRNYLEAGQIDGFVRAIRPRAEDSAEGPAGESRVPVFVFHPAGGSTVVYEPLLKRLPADTPMYGFERVEGSIEERVAVYVPKLIEMQGDGPYILAGWSLGGVLAYACAIGLRSAGKEVAWVGLIDAVRAGEEIPQTKEEIRKRWDRYARFAERTFNVTVPEIPYEQLEELDDEGQVRFVLDVVSQSGVQIPAGIIDHQRTSYLDNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRKPDGGWGEYVSDLEVVPIGGEHIQAIDEPIIAKVGEHMSQALNKIEAEQKAPK
Bibliography
No article yet recorded
