Gene ML0104c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). Polymerizes arabinose into the arabinan of arabiogalactan [Catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]. |
| Product | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) |
| Comments | ML0104c, len: 1083 aa. Probable embB, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), highly similar to Rv3795|P72030|AL123456 embB, probable indolylacetylinositol arabinosyltransferase from M. tuberculosis (1098 aa), Fasta scores: E(): 0, (78.0% identity in 1101 aa overlap); and to other putative mycobacterial arabinosyltransferases. Also similar to ML0105 and ML0106 from M. leprae. Involved in resistance to ethambutol in M. tuberculosis. In M. tuberculosis embA is thought to be regulated by embR, but this regulator doesn't exist in M. leprae. Contains hydrophobic, possible membrane-spanning regions. |
| Functional category | Cell wall and cell processes |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 136573 | 139824 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0104c|embB
MSVIYRAHRVAIANRTASRNVRVARWVAAIAGLIGFVSSVVTPLLPVVQTTATLNWPQNGQLNSVTAPLISLTPVDITATVPCAVVAALPPSGGVVLGTAPKQGKDANLNALFIDVNSQRVDVTDRNVVILSVPRNQVAGDAGAPGCSSIEVTSTHAGTFATFVGVTDSAGNPLRGGFPDPNLRPQIVGVFTDLTGGAPSGLRLSATIDTRFSSTPTTLKRFAMMLAIITTVGALVALWRLDQLDGRRMRRLIPARWSMFTLVDVAVIFGFLLWHVIGANSSDDGYQMQMARTADHSGYMANYFRWFGSPEDPFGWYYNLLALMIHVSDASMWIRLPDLICGVACWLLLSREVLPRLGPAIVGFKPALWAAGLVLLAAWMPFNNGLRPEGQIALGALITYVLIERAITYGRMTPVALATLTAAFTIGIQPTGLIAVAALLAGGRPMLYILVRRHRAVGAWPLVAPLLAAGTVVLTVVFAEQTLSTVLEATKVRTAIGPAQAWYTENLRYYYLILPTVDGSLSRRFGFLITALCLFTAVLITLRRKQIPGVARGPAWRLIGTILGTMFFLTFAPTKWVHHFGLFAALGAAVAALTTVLVSHEVLRWSRNRMAFLAALLFVMTLCFATTNGWWYVSSYGVPFNSAMPRIDGITFSTIFFILFAIVALYAYYLHFTNTGHGEGRLIRTLTVSFWAPIPFAAGLMTLVFIGSMVAGIVRQYPTYSNGWANIRALTGGCGLADDVLVEPDSNAGYMTALPSNYGPLGPLGGVNAIGFTANGVPEHTVAEAIRITPNQPGTDYDWEAPTKLKAPGINGSVVPLPYGLNPNKVPIAGTYTTGAQQQSRLTSAWYQLPKPDDRHPLVVVTAAGKITGNSVLHGHTYGQTVVLEYGDPGPNGGLVPAGRLVPDDLYGEQPKAWRNLRFARSQMPFDAVAVRVVAENLSLTPEDWIAVTPPRVPELRSLQEYVGSSQPVLLDWEVGLAFPCQQPMLHANGVTDIPKFRITPDYSAKKIDTDTWEDGANGGLLGITDLLLRAHVMSTYLARDWGRDWGSLRKFDPLVDTHPAQLDLDTATRSGWWSPGKIRIKP
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