Gene ML0106c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). Polymerizes arabinose into the arabinan of arabiogalactan [Catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]. |
| Product | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) |
| Comments | ML0106c, len: 1070 aa. Probable embC, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), highly similar to Rv3793|P72059|AL123456 embC, indolylacetylinositol arabinosyltransferase from M. tuberculosis (1094 aa), Fasta scores: E(): 0, (82.8% identity in 1075 aa overlap); and to other putative mycobacterial arabinosyltransferases. Also similar to ML0104 and ML0105 from M. leprae. Involved in resistance to ethambutol in M. tuberculosis. Contains hydrophobic, possible membrane-spanning regions. |
| Functional category | Cell wall and cell processes |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 144115 | 147327 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0106c|embC
VSGAGANYWIARLLAVIAGLLGALLAMATPFLPVNQNTAQLNWPQNSTFESVEAPLIGYVATGLNVTVPCAAAAGLTGPQSAGQTVLLSTVPKQAPKAVDRGLLIQRANDDLVLVVRNVPVVSAPMSQVLSPACQRLTFAAYFDKITAEFVGLTYGPNAEHPGVPLRGERSGYDFRPQIVGVFTDLSGPIPTGLNFSATIDTRYSSSPTLLKTIAMILGVVLTIVALVALHLLDTADGTQHRRLLPSRWWSIGCLDGLVITILAWWHFVGANTSDDGYILTMARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVTTTSAWMRVPTLAMALTCWWLISREVIPRLGHAAKASRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATSRLLPVAVACIVGALTLFSGPTGIASIGALLVAVGPLLTILQRRSKQFGAVPLVAPILAASTVTAILIFRDQTFAGESQASLLKRAVGPSLKWFDEHIRYERLFMASPDGSVARRFAVLALLVALSVAVAMSLRKGRIPGLAAGPSRRIIGITVTSFLAMMFTPTKWTHHFGVFAGLAGSLGALAAVAVASAALRSRRNRTVFAAVVLFVVALSFASVNGWWYVSNFGVPWSNSFPKLRWSLTTALLELTVIVLLLAAWFHFVATTNGSAKTRFGVRIDRIVQSPIAIATWSLVIFEVASLTMAMIGQYPAWTVGKSNLQALTGQTCGLAEEVLVEQDPNAGMLLPVSTPVADALGSSLAEAFTANGIPADVSADPVMEPPGDRSFVKENGMTTGGEAGNEGGTNATPGINGSRAQLPYNLDPARTPVLGSWQSGIQVVARLRSGWYRLPARDKAGPLLVVSAAGRFDHHEVKLQWATDSGAASGQPGGAFQFSDVGASPAWRNLRLPLSAIPSMATQIRLVADDEDLAPQHWIALTPPRIPQLRTLQDVVGYQDPVFLDWLVGLAFPCQRPFDHQYGVDETPKWRILPDRFGAEANSPVMDNNGGGPLGVTELLLKATTVASYLKDDWSRDWGALQRLTPYYPNAQPARLSLGTTTRSGLWNPAPLRH
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