Gene ML0134 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD22
Gene length2124 bp
IdentifierML0134
Location 180027 bp
Protein summary information
Molecular mass76103.1 Da
Isoelectric point4.9
Protein length708 amino acids
Structural information
PFAMPF00501, PF00550
Orthologs
M. tuberculosis H37RvRv2948c
M. lepromatosis Mx1-22AMLPM_0134
Cross-references
UniProtQ9CD82
Gene OntologyCatalytic activity, Cofactor binding, Metabolic process, Acp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)
CommentsML0134, len: 707 aa. Probable fadD22, fatty-acid-CoA synthetase (EC 6.2.1.-). Highly similar to many e.g. Rv2948c|P96283|AL123456 probable fadD22, fatty-acid-CoA synthase from M. tuberculosis (705 aa), Fasta scores: E(): 0, (75.9% identity in 705 aa overlap); and similar to Q59760|L42322 badA, benzoate-coenzyme A ligase from Rhodopseudomonas palustris (521 aa), Fasta scores: E(): 0, (31.4% identity in 494 aa overlap). Also similar to ML1051, ML1994, ML2257 and ML2546 from M. leprae. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme.
Functional categoryLipid metabolism
Coordinates
TypeStartEndOrientation
CDS180027182150+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0134|fadD22
MRSENLAALLARQAAEAGWYDKPAYFAPDVVTHGQIHDGAVRLGEVLRNRGLSAGDRVLLCLPDSPDLVQLLLACLARGIMAFLANPELHRDDYAFPERDTAAALVITNGSLRDRFQSSNVVEPAELLSDATRVEPSDYEPVSGDAYAFATYTSGTTGKPKAAIHRHADPFTFVDAMCRKALRLTPQDIGLCSARMYFAYGLGNSVWFPLATGGSAVISSVPVSAESAAMLSTRFEPSVLYGVPSFFARVVGACSPDSFRSLRCVVTAGEALEPALAERLVEFFGGIPILDGIGSSEVGQTFVSNSVDDWRVGTLGKVLPPYEIRVVAPDGATAGSGIEGNLWVRGPSIAQSYWNRPDSLLENGDWLNTRDRVRIDGDGWVTYGCRADDTEIVGGVNINPREVERLIIEADAVAEAAVVGVREFTGASTLQAFLVPAVGAFIDESVMRDVHRRLLTQLTAFKVPHRFAIIERLPRSTNGKLLRNVLRAQSPTKPIWELSLTESQSATKAQLDGRPASNAHAQAAVGHAAGATLKQRLSALQQERERLVVEAVCAEAVKMLGESDPGLINRDLAFSDLGFDSQMTVTLCNRLAVVTGLRLPETVGWDYGSISGLSRYLEAELSGVRSRPETPLSANSGAKGLSPIDEELKKVEEMVVAIGASEKQRVADRLRALLGIIVDGEAGLSKRIQAASTPDEIFQLIDSELCE
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