Gene ML0137c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemmpL7
Gene length2709 bp
IdentifierML0137c
Location 189253 bp
Protein summary information
Molecular mass94756.4 Da
Isoelectric point8.16
Protein length903 amino acids
Structural information
PFAMPF03176
Orthologs
M. tuberculosis H37RvRv2942
M. lepromatosis Mx1-22AMLPM_0137
Cross-references
UniProtQ7AQN7
Gene OntologyMembrane
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductConserved transmembrane transport protein MmpL7
CommentsML0137c, len: 902 aa. mmpL7, conserved transmembrane transport protein (see citations below), member of RND superfamily, similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942|MML7_MYCTU|P96289, mmpL7, conserved transmembrane transport protein (920 aa), Fasta scores: E(): 0, (68.6% identity in 881 aa overlap). Also similar to ML1231 and ML2378 and the pseudogene ML2375 from M. leprae. Contains hydrophobic, possible membrane-spanning regions. Belongs to the MmpL family. In M. tuberculosis it has been experimentaly shown that FadD28 and MmpL7 are transcriptionally coupled.
Functional categoryCell wall and cell processes
Coordinates
TypeStartEndOrientation
CDS189253191961-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0137c|mmpL7
VSTDDSHRSLRLANLLVITAWITAVVIANLIFTLTQAKLRDKNSVLLPQDTMTVTTTNQIAQAFPGTGTNAIAYLVVEGNRTLEPEDQPYYDSAVNALRADTHDVGSVLDWWSDPLTAPLGTSPDSRSAIALIWLQGEAGTTRARASLGAIRSVVRQLPPSEELRARIVVPATTNNMPMEMTAWQGMAIVTAAAVIAILFLLRARQAIRIVVIMLLTADFSLAAAWPLAAVVQRQTGGTVSVFSWNLAAVLTIGTITASTLLASRSYTGDSAAPTCRAHLPALALLGACVALLTGTLLLARTPALHSVGTVALGVVVALAASLTLLPTLIKLAGPSGQISPQVNGNTWTRRLLVPNFSSPARLTAVVLATCALPVIGMRLGLAEDHTAQSGTQILPGNLLPDILLIKSARDLRDPAALIAIDQVSHRLMEIPGVRKVESAAWPAGVPWNDASLSSAAGRLADQMSQQAGSFVPAVTAIKQMKTMIDQMSSTVDELESTVNVALAGAHQVQQYLNPVLSAARNIKSKTAEFSGYLDTVRGWVVSVTNCPNDVLCSAMRKVIEPYDKVAASMDQLSNGVDRISAISDQTISSFNEAPHMVAQMRSALKQARSFIPRLESTIQELMPQIAQASAMLKNLSRDFADTGEGGFHLPMKELMSSSYQHVRESMFSSDGTATRLVVYTNEHNPGLDTAARAQQLEIAAGKAMKYGSLVDSRITLGGAAQVAVAARAALTHDAVLLAGMLFAVVALASMWVSAGSGVAVGLGVLAAYLGGLGISVALWQHILGHELQASVPLVSFAILAPCGVLYLVTSLEAARVSAEAKTAATVSVRRAVVPLTVLGAIFGAGLVVAEASFSALSQVGTVLVIALGALTKVEQVLISYHAEAAMPAWSKLPSRLSGGPN
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