Gene ML0138c (acoas)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) |
| Comments | ML0138c, len: 579 aa. Probable fadD28 (alternate gene name: acoas), fatty-acid-CoA synthetase (EC 6.2.1.-) (see citations below), highly similar to several fatty-acyl-CoA synthases from M. tuberculosis e.g. Rv2941|P96290|AL123456 fadD29 (580 aa), Fasta scores: E(): 0, (81.9% identity in 580 aa overlap); and to P71495|U75685 fatty-acyl-CoA synthases from Mycobacterium bovis BCG (582 aa), Fasta scores: E(): 0, (81.4% identity in 580 aa overlap). Similar to the domains of some polyketide synthases e.g. Q50857|U24657 safB, saframycin Mx1 synthetase B from Myxococcus xanthus (1770 aa), Fasta scores: E(): 0, (35.8% identity in 590 aa overlap). And similar to ML0100, ML0132, ML0243, ML1234, ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. |
| Functional category | Lipid metabolism |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 192013 | 193752 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0138c|fadD28
MSVRSIPAVLRTCARLQPNDPVFTFMDYEQDWDGVKITLTWSQLYRRTLNVAQELNRCGSTGDRVAISAPQGLDYVVAFLGALQAGRIAVPLSVPQGGVTDERFESVLNDSSPVAILTTSPAVDDVVHHVTQRPDESTPSIIEVDLLDLDSPNGSGDGNGDHLSTAYLQYTSGSTRTPAGVMISHHNLRANFEQLMSTYLADTDGVFPVGGMSVSWLPFYHDMGLILGVCVPILGGCPAVLTSPVSFLQRPARWMHMLASEFPVFSAAPNFAFELATKKISDDDMIGVDLGNIHIILNGSERVQPATIKRFNNRFARFNLKEKAVRPSYGLAEATVYVATSRSGQPAELVDFDAESLSTGQAKTCTSGNGTSLISYVLPPSPIVRIVDSDTCIQCQDGTVGEIWVHGDNVADGYWQKPDESERTFGGKIAAPSRGTPEGPWLRTGDSGFVIDGKMFIIGRIKDLLIVYGRNHSPDDIEGTIQEITRGRCAAISVPDRNTEKLVAIIELKKLGDADQYAMDRLGAIKREVISALSNSHGLSVSDVVLVAPGSIPITTSGKVRRSTCVERYRQDQFDRLDA
Bibliography
No article yet recorded
