Gene ML0153 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameuvrD1
Gene length2337 bp
IdentifierML0153
Location 214272 bp
Protein summary information
Molecular mass85635.2 Da
Isoelectric point5.02
Protein length779 amino acids
Structural information
PFAMPF00580
Orthologs
M. tuberculosis H37RvRv0949
M. lepromatosis Mx1-22AMLPM_0153
Cross-references
UniProtQ9CD72
Gene OntologyAtp-dependent dna helicase activity, Dna binding, Dna repair, Atp binding
Enzyme Classification3.6.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable ATP dependent DNA helicase UvrD1
CommentsML0153, len: 778 aa. Probable uvrD1, ATP dependent DNA helicase (EC 3.6.1.-), highly similar to Rv0949|P71561|AL123456 uvrD1, ATP dependent DNA helicase from M. tuberculosis (771 aa), Fasta scores: E(): 0, (81.4% identity in 780 aa overlap). Similar to many DNA helicases e.g. PCRA_BACST|P56255 pcrA, ATP-dependent helicase from Bacillus stearothermophilus (724 aa), Fasta scores: E(): 0, (43.8% identity in 774 aa overlap). Also similar to ML0637 from M. leprae. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the UvrD subfamily of helicases. Note that previously known as uvrD.
Functional categoryInformation pathways
Coordinates
TypeStartEndOrientation
CDS214272216608+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0153|uvrD1
MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVHEGSPLLIVAGAGSGKTTVLARRIAYLIAARSVGVSQILAITFTNKAAAEMRERVARLVGDHTGPSMWVSTFHSTCVRILRNQASLIGGLNSNFSIYDVDDSRSLLQMIGQDMGLDIKRYSPRLMANAISNLKNELIDAESAVANLSSDTDDLARTVATVYGEYQRRLRTANALDFDDLIGETVGILQAFPQIAEHYRRRFRHVLVDEYQDTNHAQYVLVRELVGHGARNSPDDMPPGELCVVGDADQSIYAFRGSTISNIEDFERDYPDTTTILLEQNYRSTQNILSAANSVIARNFGRRDKRLWTDAGKGELIVGYVSDNEHDEAKFIADEIDALVGGGEITYDDVAVLYRANNLSRSLEEVFIPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNPGDAVSMRRILNTPRRGIGDRAEACVSVYAENTGTSFADALQAVAEGKVPMLNTRSVKAIAGFVALLDDLRCRVDDDLGELVESVLERSGYLRELESSTDPQELARLDNLNELVSFAHEFSTEQANAAALAKSLHTPEDEDVPDTGALAAFLEKVSLMSDTDQIPENNSGVVTLMTLHAAKGLEFPVVFVTGWEDGMLPHMRTLGDPTELSEERRLAYVGITRARQRLYLSRAITRSSWGQPILNPESRFLREIPPELIDWRRSILTDSYSTPASGASRFGRVRPSSIRSGASKRALLVLAPGDRVTHDKYGLGRVEEVSGVGESAISLIDFGSSGRIKLMHNHAPVTKL
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