Gene ML0161
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in de novo purine biosynthesis (at the ninth and tenth steps) [Catalytiv activity 1: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide] [Catalytiv activity 2: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide]. |
| Product | Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transformylase) and inosinemonophosphatecyclohydrolase (IMP cyclohydrolase) (inosinicase) (IMP synthetase) (ATIC) |
| Comments | ML0161, len: 527 aa. Probable purH, bifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase (EC 2.1.2.3) and inosine-monophosphate (IMP) cyclohydrolase (EC 3.5.4.10), highly similar to Rv0957|PUR9_MYCTU|P71553 purH from (523 aa), Fasta scores: E(): 0, (88.1% identity in 520 aa overlap). Similar to many e.g. PUR9_BACSU|P12048 purN, phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase from Bacillus subtilis (512 aa), Fasta scores: E(): 0, (43.2% identity in 519 aa overlap). Previously sequenced as PUR9_MYCLE|Q9Z5H5 (527 aa), Fasta scores: E(): 0, (100.0% identity in 527 aa overlap). Contains Pfam match to entry PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme. Belongs to the PurH family. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 224616 | 226199 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0161|purH
MSSDGERDMARKPIRRALISVYDKTGLIDLAQGLNAAGVDIVSTGSTAKAIADQGIAVTPVEELTGFPEVLDGRVKTLHPRVHAGLLADLRKPEHAAALEQLGIEAFELVVVNLYPFSQTVKSGATVDECVEQIDIGGSSMVRAAAKNHPSVAVVTDPLGYVGVLAAVQGGGFTLAERKMLASMAFQHIAEYEIAVASWMQSTLAPEQPPTAFPQWFGRSWRRSAILRYGENPHQQAALYSDPSACPGLAQAEQLHGKNMSYNNFTDADAAWRAAFDHEQSCVAIIKHANPCGIAISSLSVADAHRKAHECDPLSAYGGVIAANTEVSLEMAEYVSTIFTEVIVAPSYAPGAVDVLSCKKNVRVLVASAPLRGGSELRPVSGGLLIQQPDQLDTAGDNPANWTLATGSPAGPATLTDLVFAWRACRAVKSNAIVIAADGATIGVGMGQVNRVDAARLAVERGGDRVRGAVVASDAFFPFADGLQTLAAAGVTAIVHPGGSVRDAEVTAAATKAGVTLYLTGVRHFVH
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