Gene ML0176
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable serine protease (serine proteinase) |
| Comments | ML0176, len: 382 aa. Probable secreted or membrane serine protease (EC 3.4.21.-), highly similar to Rv0983|O53896|AL123456 probable serine protease from M. tuberculosis (464 aa), Fasta scores: E(): 0, (80.7% identity in 383 aa overlap); and in part to Rv1223|O06291|AL123456 htrA, putative serine protease from M. tuberculosis (549 aa), Fasta scores: E(): 0, (41.8% identity in 347 aa overlap). Similar to many putative serine protease e.g. Q8NS10 trypsin-like serine protease from Corynebacterium glutamicum (413 aa), Fasta scores: E(): 1.3e-35, 47.2% identity in 362 aa overlap. Also similar to ML1078 and ML2659 from M. leprae. Previously sequenced as Q9Z5G6|AL035500 (452 aa), Fasta scores: E(): 0, (100.0% identity in 382 aa overlap). Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains Pfam match to entry PF00089 trypsin, Trypsin. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 243054 | 244202 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0176|pepD
MIPPGRVADRRPRAGMLAVSALAIAVVSAGIGGVAATVVALGTRVAGGNGAGPVTGPAASVPAANMPSGSVEQVAVKVVPSVVMLETDLGRQSEEGSGVILSADGLILTNNHVVAVAAKPGGGPGGGLSPKTTVTFFDGRTASFTVVGADPTSDIAVVRVQSISGLTPITMGSSADLRVGQPVVAVGSPLGLAGTVTSGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALVNMGGQLVGVNSAIATLGADSGDAQSGSIGLGFAIPVDQAKRIADELISTGKATHASLGVQVATDKGTPGAKVMDVVAGGAAANAAVPKGVVLTKVDDRLISSADALVAAVRSKAPGDKVSLTYQDQSGSSRTVQVTLGKAEQ
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