Gene ML0177
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Thought to be involved in molybdopterin biosynthesis. Catalyzes the dehydratation of 4A-hydroxytetrahydropterins [Catalytic activity: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4A-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O] |
| Product | Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-A-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) |
| Comments | ML0177, len: 181 aa. Possible moaB2, pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), highly similar to Rv0984|O53897|AL123456 moaB2, possible pterin-4-alpha-carbinolamine dehydratase from M. tuberculosis (181 aa), Fasta scores: E(): 0, (92.7% identity in 179 aa overlap). Similar to many others e.g. Q9RKA9 Molybdenum cofactor biosynthesis protein from Streptomyces coelicolor A3(2) (179 aa), Fasta scores: E(): 5e-21, (50.0% identity in 150 aa overlap); and to the C-terminal halves of CNX1_ARATH|Q39054 cnx1, multifunctional two-domain protein involved in molybdenum cofactor biosynthesis from Arabidopsis thaliana (670 aa), Fasta scores: E(): 7.7e-10, (36.4% identity in 187 aa overlap); and MOCB_SYNP|Q56208 moaCB, molybdenum cofactor biosynthesis protein from Synechococcus sp. (strain PCC 7942) (319 aa), Fasta scores: E(): 1.3e-09, (35.9% identity in 142 aa overlap). Previously sequenced as Q9Z5G5|AL035500 (181 aa), Fasta scores: E(): 0, (99.4% identity in 181 aa overlap). |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 244225 | 244770 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0177|moaB
VLVDKQLSELGYTVAPMEKGVELVVGRALIVVVDDRTAHGDEDHSGPLVTELLTEAGFVVDGVVAVAADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVAPEATREILDREILGIAEAIRASGLSAGITDAGLSRGLAGVSGSTLVVNLAGSRYAVRDGMATLNPLATQIIGQLSSLEI
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