Gene ML0200 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametopA
Gene length2844 bp
IdentifierML0200
Location 266033 bp
Protein summary information
Molecular mass104055.0 Da
Isoelectric point8.32
Protein length948 amino acids
Structural information
PFAMPF01131, PF01751
Orthologs
M. tuberculosis H37RvRv3646c
M. lepromatosis Mx1-22AMLPM_0200
Cross-references
UniProtO69548
Gene OntologyDna topoisomerase type i activity, Dna topological change, Dna unwinding involved in dna replication, Chromosome, Atp binding
Enzyme Classification5.99.1.2
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (topt I)
CommentsML0200, len: 947 aa. Probable topA, DNA topoisomerase I (EC 5.99.1.2) (see citation below), highly similar to Rv3646c|TOP1_MYCTU|Q59567 topA, DNA topoisomerase I from M. tuberculosis (934 aa), Fasta scores: E(): 0, (84.3% identity in 942 aa overlap); and many other e.g. Q9X909|TOP1_STRCO DNA topoisomerase type I from Streptomyces coelicolor (952 aa). Previously sequenced as TOP1_MYCLE|O69548 (947 aa), Fasta scores: E(): 0, (100.0% identity in 947 aa overlap). Contains Pfam match to entry PF01131 Topoisom_bac, Prokaryotic DNA topoisomerase. Contains Pfam match to entry PF01751 Toprim, Toprim domain. Contains PS00396 Prokaryotic DNA topoisomerase I active site. Belongs to the prokaryotic typeI/III topoisomerase family.
Functional categoryInformation pathways
Coordinates
TypeStartEndOrientation
CDS266033268876+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0200|topA
MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPVKRPAKKARKVPAKKAARLAPARGISQSPR
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