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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductProbable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (topt I)
CommentsML0200, len: 947 aa. Probable topA, DNA topoisomerase I (EC 5.99.1.2) (see citation below), highly similar to Rv3646c|TOP1_MYCTU|Q59567 topA, DNA topoisomerase I from M. tuberculosis (934 aa), Fasta scores: E(): 0, (84.3% identity in 942 aa overlap); and many other e.g. Q9X909|TOP1_STRCO DNA topoisomerase type I from Streptomyces coelicolor (952 aa). Previously sequenced as TOP1_MYCLE|O69548 (947 aa), Fasta scores: E(): 0, (100.0% identity in 947 aa overlap). Contains Pfam match to entry PF01131 Topoisom_bac, Prokaryotic DNA topoisomerase. Contains Pfam match to entry PF01751 Toprim, Toprim domain. Contains PS00396 Prokaryotic DNA topoisomerase I active site. Belongs to the prokaryotic typeI/III topoisomerase family.
Functional categoryInformation pathways
Coordinates
TypeStartEndOrientation
CDS266033268876+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0200|topA
MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPVKRPAKKARKVPAKKAARLAPARGISQSPR
      
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