Gene ML0224
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in dihydrofolate biosynthesis (at the second step). Catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [Catalytic activity: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = pyrophosphate + dihydropteroate]. |
| Product | Probable dihydropteroate synthase 1 FolP1 (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate dipyrophosphorylase 1) |
| Comments | ML0224, len: 284 aa. Probable folP1, dihydropteroate synthase 1 (EC 2.5.1.15), highly similar to Rv3608c|DHP1_MYCTU|O06274 probable folP1, dihydropteroate synthase 1 from M. tuberculosis (280 aa), Fasta scores: E(): 0, (76.8% identity in 284 aa overlap); and similar to many others e.g. P28822|DHPS_BACSU dihydropteroate synthase from Bacillus subtilis (285 aa). Previously sequenced as O69530|AL023093 (284 aa), Fasta scores: E(): 0, (99.6% identity in 284 aa overlap). Also similar to ML1063 from M. leprae. Mutations in this gene result in diaminodiphenylsulfone resistance. Contains Pfam match to entry PF00809 DHPS, Dihydropteroate synthase. Contains PS00793 Dihydropteroate synthase signature 2. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 296696 | 297550 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0224|folP1
VSLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAIVDVGGESTRPGAIRTDPRVELSRIVPVVKELAAQGITVSIDTTRADVARAALQSGARIVNDVSGGRADPAMAPLVAEAGVAWVLMHWRLMSAERPYEAPNYRDVVAEVRADLLAGVDQAVAAGVDPGSLVIDPGLGFAKTGQHNWALLNALPELVATGVPILLGASRKRFLGRLLAGADGAVRPPDGRETATAVISALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVRCDG
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