Gene ML0235
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable ATP-dependent Clp protease ATP-binding subunit ClpC |
| Comments | ML0235, len: 848 aa. Probable clpC, ATP-dependent clp protease ATP-binding subunit (EC 3.4.-.-), equivalent to Rv3596c|CLPC_MYCTU|O06286 clpC, ATP-dependent clp protease ATP-binding subunit from M. tuberculosis (848 aa), Fasta scores: E(): 0, (97.2% identity in 845 aa overlap). Also highly similar to members of the clpA/clpB family e.g. P37571|CLPC_BACSU clpC, negative regulator of genetic competence (clpC-family) from Bacillus subtilis (810 aa), and HLYB_TREHY|Q54316 tlyB, hemolysin B from Treponema hyodysenteriae (828 aa), Fasta scores: E(): 0, (51.4% identity in 812 aa overlap). Also similar to ML2490 from M. leprae. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the clpA/clpB family, clpC subfamily. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 306003 | 308549 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0235|clpC
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLDSLGISLEAVRSQVEDIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTAAAMESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKQLVAQRAEREKQWRSGDLDVIAEVDDEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFHQLSRDEIIRMVDLMISRVANQLKVKDMTLELTNKAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSAGGPEPVEQ
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