Gene ML0238c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | It is probably essential for cell survival, being required not only for elongation of protein synthesis but also for the initiation of all mRMA translation through initiator tRNA(Fmet) aminoacylation [Catalytic activity: ATP + L-methionine + tRNA(met) = AMP + diphosphate + L-methionyl-tRNA(met)] |
| Product | Probable methionyl-tRNA synthase MetS |
| Comments | ML0238c, len: 537 aa. Probable metS (MetG), methionyl-tRNA synthetase (EC 6.1.1.10), highly similar to Rv1007c|SYM_MYCTU|O05593 metS, methionyl-tRNA synthetase from M. tuberculosis (519 aa), Fasta scores: E(): 0, (85.7% identity in 516 aa overlap). Similar to several others e.g. SYM_BACST|P23920 metG (metS), methionyl-tRNA synthetase from Bacillus stearothermophilus (649 aa), Fasta scores: E(): 0, (40.9% identity in 550 aa overlap). Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family. Strong, to cysteinyl-tRNA synthetase. |
| Functional category | Information pathways |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 312208 | 313821 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0238c|metS
MRPYYITTAIAYPNAAPHIGHAYEYIATDAIARFKRLDGLDVRFLTGTDEHGLKVAQAAEAAGVPTAQLARRNSGVFQRMQEALHISFDRFIRTTDADHYKAAKEIWRRMDAAGDIYLGTYSGWYSVRDERFFVDSETKLLDNGIRVAVETGTLVTWTEKEQTYFFRLSAYVDKLLAHYDANPDFIGPEVRRNEVISFVSGGLEDFSISRTSFDWGVQVPEHPDHVMYVWIDALTNYLTGAGFPDTDSELFGRYWPANLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNHGEKMSKSVGNIVDPMALVQTFGVDQVRYFLLREIPFGQDGNYSEEAIITRMNTDLANEFGNLAQRSLSMVAKNLGGVVPEPSEFTSADTALLTTADGLLERVRGNFDGQAMNLALEAIWLMLGEANKYFSSQQPWILRKSESEADQARFRTVLYTTCEVVRIAALLVQPVMPESAGKMLDLLGQEEDQRAFTAVSVRLAPGTVLPPPTGVFPRYQPSEIEGADPVKSSSKRREHNKRRE
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