Gene ML0248c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Catalyzes the formation of PRPP from ATP and ribose 5-phosphate. PRPP is then used in various biosynthetic pathways, as for example in the formation of purines, pyrimidines, histidine and tryptophan. [Catalytic activity: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate] |
| Product | Probable ribose-phosphate pyrophosphokinase PrsA (Phosphoribosyl pyrophosphate synthetase) (PRPP synthetase) |
| Comments | ML0248c, len: 327 aa. Probable prsA, ribose-phosphate pyrophosphokinase (EC 2.7.6.1), equivalent to Rv1017c|P96383|AL123456 prsA, ribose-phosphate pyrophosphokinase from M. tuberculosis (326 aa), Fasta scores: E(): 0, (92.0% identity in 326 aa overlap). Similar to others e.g. SW:KPRS_BACSU|P14193 prs, ribose-phosphate pyrophosphokinase from Bacillus subtilis (317 aa), Fasta scores: E(): 0, (45.8% identity in 323 aa overlap). Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Belongs to the ribose-phosphate pyrophosphokinase family. Cofactor: both inorganic phosphate and magnesium ion are required for enzymes stability and activity. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 323462 | 324445 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0248c|prsA
MLSHDWTDNRKNLMLFSGRAHPELAEQVAKELDMHVTTQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVNTWLMEQLIMIDALKRGSAKRITAVIPFYPYARQDKKHRGREPISARLVADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIKNNYPDTNMVVVSPDSGRVRIAEKWGDALGGVPLAFIHKTRDLRVPNQVVSNRVVGEVEGRTCVLIDDMIDTGGTVAGAVQLLRNDGASDVIIAATHGVLSPPAAERLAQYGTREVIVTNTLPIGEEKRFPQLTVLSIAPLLASTIRAIFENGSVTGLFDGEA
Bibliography
No article yet recorded
