Gene ML0275c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable O-succinylhomoserine sulfhydrylase MetZ (osh sulfhydrylase) |
| Comments | ML0275c, len: 406 aa. Probable metZ, O-succinylhomoserine sulfhydrylase (EC 4.2.99.-), equivalent, but shorter 20 aa in N-terminus to Rv0391|P95199|AL123456 metZ, o-succinylhomoserine sulfhydrylase from M. tuberculosis (406 aa), Fasta scores: E(): 0, (87.9% identity in 406 aa overlap). Similar to many others e.g. METZ_PSEAE|P55218 metZ, o-succinylhomoserine sulfhydrylase from Pseudomonas aeruginosa (403 aa), Fasta scores: E(): 0, (44.3% identity in 406 aa overlap). Previously sequenced as O69592|AL023514 (426 aa), Fasta scores: E(): 0, (100.0% identity in 406 aa overlap). Also similar to ML2394 from M. leprae. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. Belongs to the trans-sulfuration enzymes family. Could also be a cystathionine gamma-synthase (EC 4.2.99.9). |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 357557 | 358777 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0275c|metZ
MTDDRSVRTPKALPDGVTAATVGVRGGLLRSRFEETAETMYLTSGYVYESAVVAEKSFTGELDHFVYSRYGNPTVTMFEERLRLIEGAPAAFVTASGMAAVFTSLGALLASGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLVQWEQALSVPTQAVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNAFATPLLQHGLPLGVDVVIYSGTKHIDGQGRVLGGAILGDRDYIDGPVQKLMRHTGPAMSAFNAWILLKGLETLAIRVDHCNSSAHRIAEFLEKHPAVSWVRYPFLVSHPQYDLAKRQMSGGGTVVTFALNSPEDAAKQRAFEVLDRLRLIDISNNFGDVKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISIGLEDAADLIADIDQALS
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