Gene ML0304
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in signal transduction (via phosphorylation). Thought to regulate amino-acid uptake and stationary-phase metabolism. Phosphorylates the peptide substrate myelin basic protein (MBP) at serine residues [Catalytic activity: ATP + A protein = ADP + A phosphoprotein]. |
| Product | Probable serine-threonine protein kinase PknG (protein kinase G) (STPK G) |
| Comments | ML0304, len: 767 aa. Probable pknG, serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to Rv0410c|P96256|AL123456 pknG, serine/threonine protein kinase from M. tuberculosis (750 aa), Fasta scores: E(): 0, (83.1% identity in 756 aa overlap). Similar to many bacterial putative serine/threonine protein kinases e.g. CAB71204|AL138538 possible protein kinase from Streptomyces coelicolor (903 aa), Fasta scores: E(): 0, (42.0% identity in 793 aa overlap). Similar in part, to protein kinases from Myxococcus xanthus e.g. Q9XBP5|AF159692 pkn12, serine/threonine protein kinase (465 aa), Fasta scores: E(): 2.9e-10, (28.4% identity in 292 aa overlap). Previously sequenced as Q9ZBL8|AL035159) (763 aa), Fasta scores: E(): 0, (100.0% identity in 763 aa overlap). Also similar to regions of ML0016 and ML0017 from M.leprae. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature. Belongs to the Ser/Thr family of protein kinases. |
| Functional category | Regulatory proteins |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 386630 | 388933 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0304|pknG
MAESMKREHMDHDTEDVGQAAQRADPPSGTTEGRLQSTQAIFRPNFDDDDDLLHISVPSVDTEPQDRITPATRVLPPIRQLGGGLVEIRRVRDIDPLEALMTNPVVPESKRFCWNCGRPVGRSELEGQEADGAQGAKEGWCPYCGSPYSFLPQLSPGDIVAGQYEVKGCIAHGGLGWVYLAFDHNVNDRPVVLKGLVHSGDAEAQASAVAERQFLAEVVHPQIVQIFNFVEHKDTSGDPVGYIVMEYIGGRSLKRGSKKGNVEKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGCIYGTPGYQAPEIVRTGPTVATDIYTVGRTLAALTLNLRTRNGRYMDGLPEDDPVLTTYDSFARLLHRAINPDPRRRFSSAEEMSAQLMGVLREVVAQDTGVPRAGLSTIFSPSRSTFGVDLLVAHTDVYLDGRLHSEKLTAKDIVTALQVPLVDPTDVAAPVLQATVLSQPVQTLDSLRAARHGMLDAQGIDLAESVELPLMEVRALLDLGDVVKANRKLDDLADRVSCQWRLVWYRAVADLLTGDYASATKHFTEVLNTFPGELAPKLALAATAELAGESDEHKFYRTVWHTNDGVVSAAFGLARFQSAEGDRTGAVCTLDEVPPTSRHFTTARLTSAVTLLSGRSTNEITEQQIRDAARRVETLPPTEPRVLQIRALVLGCAMDWLADNQASANHILGFPFTKHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTL
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