Gene ML0371
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable glucosamine-fructose-6-phosphate aminotransferase GlmS (Hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (Glucosamine-6-phosphate synthase) |
| Comments | ML0371, len: 625 aa. Probable glmS, glucosamine--fructose-6-phosphate aminotransferase (EC 2.6.1.16), highly similar to Rv3436c|GLMS_MYCTU|O06253 probable glmS, glucosamine-fructose-6-phosphate aminotransferase from M. tuberculosis (623 aa), Fasta scores: E(): 0, (89.3% identity in 627 aa overlap). Similar to many others e.g. O68956|GLMS_MYCSM from Mycobacterium smegmatis (627 aa), Fasta scores: E(): 0, (84.9% identity in 630 aa overlap); O86781|GLMS_STRCO|SC6G4.18 from Streptomyces coelicolor (614 aa), Fasta scores: E(): 0, (63.3% identity in 626 aa overlap). Also similar to ML0689c a possible pseudogene similar to M. tuberculosis glmS. Previously sequenced as GLMS_MYCLE|P40831 (624 aa), Fasta scores: E(): 0, (99.7% identity in 624 aa overlap). Contains Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains 2 Pfam matches to entry PF01380 SIS, SIS domain. Belongs to the type-2 gatase domain in the N-terminal section. Belongs to the SIS family, GLMS subfamily, in the C-terminal section. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 462980 | 464857 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0371|glmS
MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRRRAGRLSNLESVLAEMVPASLAGNVGLGHIRWATHGRPTDRNAHPHRDATGKIAVVHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAVLRRLQGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGNDDAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYTIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSAMLHAKLLSNIREIQTRGAVTIVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE
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