Gene ML0381 (cpn60_1)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | 60 kDa chaperonin 1 GroEL1 (Protein Cpn60-1) (groEL protein 1) |
| Comments | ML0381, len: 537 aa. groEL1 (alternate genbe name: cpn60_1), 60 kDa chaperonin 1 (protein cpn60 1) (see citations below), highly similar to Rv3417c|CH61_MYCTU|Q59573 groEL1, 60 kDa chaperonin 1 from M. tuberculosis (539 aa), Fasta scores: E(): 0, (82.9% identity in 539 aa overlap). Also highly similar to others e.g. P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces coelicolor (540 aa), Fasta scores: E(): 0, (82.9% identity in 539 aa overlap). Previously sequenced as CH61_MYCLE|P37578 (537 aa), Fasta scores: E(): 0, (100.0% identity in 537 aa overlap). Contains Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family. Contains PS00296 Chaperonins cpn60 signature. Belongs to the chaperonin (hsp60) family. |
| Functional category | Virulence, detoxification, adaptation |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 473559 | 475172 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0381|groEL1
MSKLIEYDETARHAMEVGMNKLADTVRVTLGPRGRHVVLAKAFGGPTITNDGVTVAREIDLEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVKGGLRMVAAGANPVALGAGISKAADAVSEALLAVATPVAGKDAITQVATVSSRDEQIGALVGEGMNKVGTDGVVSVEESSTLDTELEFTEGVGFDKGFLSAYFVTDFDSQQAVLDDPLVLLHQEKISSLPELLPMLEKVTESGKPLLIVAEDLEGEALATLVVNSIRKTLKAVAVKSPFFGDRRKAFLEDLAIVTGGQVVNPETGLVLREVGTDVLGSARRVVVSKDDTIIVDGGGSNDAVAKRVNQLRAEIEVSDSEWDREKLQERVAKLAGGVAVIKVGAVTETALKKRKESVEDAVAAAKASIEEGIIAGGGSALVQCGAALKQLRTSLTGDEALGIDVFFEALKAPLYWIATNAGLDGAVVVDKVSGLPAGHGLNASTLGYGDLVADGVVDPVKVTRSAVLNAASVARMMLTTETAVVDKPAKTEEHDHHGHAH
Bibliography
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