Gene ML0389 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namechoD
Gene length1710 bp
IdentifierML0389
Location 483452 bp
Protein summary information
Molecular mass62309.9 Da
Isoelectric point9.37
Protein length570 amino acids
Structural information
PFAMPF01266
Orthologs
M. tuberculosis H37RvRv3409c
M. lepromatosis Mx1-22AMLPM_0389
Cross-references
UniProtQ9CCV1
Gene OntologyOxidoreductase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)
CommentsML0389, len: 569 aa. Probable choD, cholesterol oxidase precursor (EC 1.1.3.6), highly similar to Rv3409c|Q57307|Al123456 choD, putative cholesterol oxidase from M. tuberculosis (578 aa), Fasta scores: E(): 0, (88.6% identity in 569 aa overlap). Also similar to CHOD_STRSQ|P12676 choA, cholesterol oxidase precursor from Streptomyces sp. (strain SA-COO) (546 aa), Fasta scores: E(): 0.013, (26.6% identity in 561 aa overlap); and similar to other oxidoreductases e.g. Q9A7T6|CC1634 OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus (579 aa). Previously sequenced as Q59530|U00015 (585 aa), Fasta scores: E(): 0, (100.0% identity in 569 aa overlap).
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS483452485161+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0389|choD
MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRRFADEDFAKTSWDLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLNYANTLYVPPEPFFANQQWAHITDWHSELAPHYDQAQRMLGVVCNPTFTDADRILKEVVDEMGFGDTFVPTPVGVFFGPDGTQTPGRTVADPYFGGVGPVRTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFELRSEGLWEVHTVRTGSWLRRGRRTFTAAHLLLAAGTWGTQRLLFRMRDQGKLPRLSQRLGVLTRTNSESIVGAGTLNVMPDRDLTHGVAITSSIHPTSDTHIEPIRYGKGSNAMGLLQTLMTDGPGPEGTDVPRWRQLLHQASEDPRRMLRLINPRRWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGNGEPNPSWIPIGNEVTRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNAEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGQHDQRPRQGESYRRLAPIAPDHPVVPAEALGALRWL
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