Gene ML0395
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable GMP synthase [glutamine-hydrolyzing] GuaA (Glutamine amidotransferase) (GMP synthetase) |
| Comments | ML0395, len: 529 aa. Probable guaA, gmp synthase (EC 6.3.5.2) (see citation below), highly similar to Rv3396c|GUAA_MYCTU|Q50729 guaA, GMP synthase from M. tuberculosis (525 aa), Fasta scores: E(): 0, (86.9% identity in 525 aa overlap). Also similar to others e.g. GUAA_BACSU|P29727 guaA, GMP synthase [glutamine-hydrolyzing] from Bacillus subtilis (513 aa), Fasta scores: E(): 0, (50.7% identity in 515 aa overlap); and Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa). Previously sequenced as GUAA_MYCLE|P46810 (590 aa), Fasta scores: E(): 0, (100.0% identity in 529 aa overlap). Contains Pfam match to entry PF00958 GMP_synt_C, GMP synthase C terminal domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. Belongs to the type-1 glutamine amidotransferase family in the N-terminal section. And belongs to the GMP synthase family in the C-terminal section. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 491044 | 492633 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0395|guaA
VADSAGLDQPEPSPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTTSIEEITARDPLAIVLSGGPASVYTEGAPQLDPALFDLGLPVFGICYGFQAMAQVLGGTVARTKTSEYGRTELKVLGGDLHSGLPGVQPVWMSHGDAVTAAPDGFDVAASSSGAPVAAFENRDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLDADWTAANIAGVLVEQVRAQIGNGHAICGLSGGVDSAVAAALVQRAIGDRLTCIFVDHGLLRDGERGQVQRDFVAATGAKLVTVDAAETFLQALSGVTNPEGKRKIIGRQFIRAFEGAVRDLLGDSTFDSGIEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDNLRFKLVEPLRLLFKDEVRAVGRQLDLPEEIVARQPFPGPGLGIRIVGEVTAERLDTLRRADSIAREELTTAGLDYQIWQCPVVLLADVRSVGVQGDNRSYGHPIVLRPVSSEDAMTADWTWVPYEVLECISTRITNEVAEVNRVVLDITNKPPGTIEWE
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