Gene ML0396c (tbINO, ino1)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable myo-inositol-1-phosphate synthase Ino2 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase) |
| Comments | ML0396c, len: 369 aa. Probable ino2 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below). Identical to ML2692 a possible orthologue of M. tuberculosis ino1. Possibly a paralogue of Rv0046c|P71703|AL123456 ino1, myo-inositol-1-phosphate synthase from M. tuberculosis (367 aa), Fasta scores: E(): 0, (91.8% identity in 366 aa overlap). Highly similar to other bacterial myo-inositol-1-phosphate synthase and hypothetical proteins e.g. Q8NLE6 Myo-inositol-1-phosphate synthase from Corynebacterium glutamicum (363 aa), Fasta scores: E(): 0, (73.9% identity in 361 aa overlap); and Q9X8T5|SCH24_21c Hypothetical protein from Streptomyces coelicolor (360 aa). Previously sequenced as Q57240|U00015 (369 aa), Fasta scores: E(): 0, (100.0% identity in 369 aa overlap). Contains Pfam match to entry PF01658 Inos-1-P_synth, Myo-inositol-1-phosphate synthase. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 492715 | 493824 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0396c|ino2
MSEHNPAGAPGASTEVRVAIVGVGNCASSLVQGIEYYQNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGVDLSDAIFTSENNTIKIADVPPTNVVVQRGPTLDGIGKYYTDTIELSDVPPVDVVQALTEAKTDVLVSYLPVGSEEADKFYAQCAINARVAFVNALPVFIASDPVWAKKFADARVPIVGDDIKSQVGATITHRVMAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERVQSKKISKTQAVTSNVHREFNTKDIHIGPSDHVGWLDDRKWAYVRLEGRGFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASSYLMKSPPQQLPDEIARAQLEEFIIDTK
Bibliography
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