Gene ML0454c (pgsA)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable PI synthase PgsA1 (phosphatidylinositol synthase) (CDP-diacylglyceride--inositol3-phosphatidyltransferase) |
| Comments | ML0454c, len: 239 aa. Probable pgsA1 (previously known as pgsA), PI synthase/CDP-diacylglyceride--inositol phosphatidyltransferase (EC 2.7.8.11), transmembrane protein, highly similar to Rv2612c|O06202|AL123456 pgsA1 probable PI synthase from M. tuberculosis (217 aa), Fasta scores: E(): 0, (79.3% identity in 213 aa overlap); and Q9F7Y9|PGSA phosphatidylinositol synthase from Mycobacterium smegmatis (222 aa). Shows weak similarity to PGSA_ECOLI|P06978 pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (738 aa), BlastP Expect 8.6. Previously sequenced as O07149|Z96801 (239 aa), Fasta scores: E(): 0, (100.0% identity in 239 aa overlap). Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Note that in Mycobacterium smegmatis, the psgA homologue is essential to the survival of the bacteria and seems cannot be compensated by any other enzyme of Mycobacterium smegmatis. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 554334 | 555053 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0454c|pgsA
MSKVPFLSRATFTRLTTPTARALLRVGLTPDAITVLGTIVAASGALVLFPIGKLFAGTLVVWFFVLFDMLDGAMARERGGGTRYGAVLDATCDRISDGAVFCGLLWWMAFGLHSKHLVVATLICLVTSQVISYIKARAEASGLRGDDGLIERPERLIIVLVGAGLSDFPVYSLPWALSVAMWLLVVASLITCAQRLHTVHTSPGATDRIARPGYPSASDRTNATNGGQPGPGNLGTGEP
Bibliography
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