Gene ML0456c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethrS
Gene length2109 bp
IdentifierML0456c
Location 555663 bp
Protein summary information
Molecular mass78372.1 Da
Isoelectric point5.28
Protein length703 amino acids
Structural information
PFAMPF00587, PF03129, PF07973
Orthologs
M. tuberculosis H37RvRv2614c
M. lepromatosis Mx1-22AMLPM_0456
Cross-references
UniProtO07151
Gene OntologyCytoplasm, Threonine-trna ligase activity, Threonyl-trna aminoacylation, Zinc ion binding, Atp binding
Enzyme Classification6.1.1.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)
CommentsML0456c, len: 702 aa. Probable thrS, threonyl-tRNA synthetase (Threonine--tRNA ligase) (EC 6.1.1.3), highly similar to Rv2614c|SYT_MYCTU|O06200 thrS, threonyl-tRNA synthetase from M. tuberculosis (692 aa), Fasta scores: E(): 0, (84.0% identity in 702 aa overlap). Similar to many e.g. SYT_THETH|P56881 from Thermus aquaticus (659 aa), Fasta scores: E(): 0, (45.0% identity in 645 aa overlap); P00955|SYT_ECOLI from Escherichia coli (642 aa). Previously sequenced as SYT_MYCLE|O07151 (702 aa), Fasta scores: E(): 0, (100.0% identity in 702 aa overlap). Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to the class-II aminoacyl-tRNA synthetase family. Cofactor: Binds 1 zinc ion.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS555663557771-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0456c|thrS
MSAPVHPVPGADGGDPLRPATPGLRSPQVPIQVPAGSTAAAAVSEAGLPTHGAPDAIVVVRDADGKLRDLSWVPDVDVEVTPVPVNTDDGRSVIRHSTAHVLAQAVQDLFPQAKLGIGPPITDGFYYDFDVAEPFTPEDLKALEKRMRQIVKEGQLFSRRIYESKEQARTEWAGEPYKLELVDDESGDAEIMEVGGDELTAYDNLNARNGERIWGDLCRGPHIPTTKHIPAFKLTRSSAAYWRGNQKNASLQRIYGTAWESQEALDRHLEMITEAQRRDHRKLGIELDLFSFPDEIGSGLAIFHPKGSIVRREMEEYSRRKHIEAGYQFVNTPHITKAQLFHTSGHLDWYAEGIFPPMHLDAEHNDDGTVRKPGQDYYLKPMNCPMHTLIFSSRGRSYRELPLRLFEFGTIYRYEKSGVVHGLTRARGFTMDDSHIFCTREQLHCELASLLRFVLDLLGDYGLEDFYLELSTKDPEKFVGSEEIWEEATAALAEVAENSTLPLVPDPGGAAFYGPKISVQVRDALGRSWQMSTIQVDFNFPERFALEYTSADGTRQRPVMIHRALFGSIERFFGILTEHYAGAFPAWLAPIQVVGIPVTGEHVSYLEEVAAQLKSCGVRTEVDVSDDRMAKKIVRHTNQKVPFMLLAGDRDVRTGSVSFRFGDRTQINGVARDSAVEAIVCWIVDRENDFPTAELVKVTGGE
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