Gene ML0483
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | FORMS A COMPLEX WITH RUVA. RUVB COULD POSSESS WEAK ATPASE ACTIVITY, WHICH WILL BE STIMULATED BY THE RUVA PROTEIN IN THE PRESENCE OF DNA. THE RUVA-RUVB COMPLEX IN THE PRESENCE OF ATP RENATURES CRUCIFORM STRUCTURE IN SUPERCOILED DNA WITH PALINDROMIC SEQUENCE, INDICATING THAT IT MAY PROMOTE STRAND EXCHANGE REACTIONS IN HOMOLOGOUS RECOMBINATION. RUVAB IS AN HELICASE THAT MEDIATES THE HOLLIDAY JUNCTION MIGRATION BY LOCALIZED DENATURATION AND REANNELING. |
| Product | Holliday junction binding protein RuvB |
| Comments | ML0483, len: 349 aa. Probable ruvB, Holliday junction binding protein (EC 3.6.1.-) (see Mizrahi & Andersen 1998), highly similar to Rv2592c|RUVB_MYCTU|Q50629 ruvB, Holliday junction binding protein from M. tuberculosis (344 aa), Fasta scores: E(): 0, (94.4% identity in 342 aa overlap). Also highly similar to others e.g. Q9AE09|RUVB from Corynebacterium glutamicum (Brevibacterium flavum) (363 aa), E(): 7.2e-94, (74.850% identity in 334 aa overlap); and Q9L291|RUVB from Streptomyces coelicolor (357 aa), FASTA scores: E(): 8.1e-86, (66.859% identity in 347 aa overlap). Previously sequenced as RUVB_MYCLE|P40833 (369 aa), Fasta scores: E(): 0, (100.0% identity in 322 aa overlap). Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ruvB family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 582396 | 583445 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0483|ruvB
MSEDYLDRDVSPALTVGEADIDVSLRPRSLREFIGQPRVREQLQLVIEGAKNRGATPDHILLSGPPGLGKTSLAMIIAAELGSSLRMTSGPALERAGDLAVMLSNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVIVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPTELEGVLARAAGILGIELGVEAGAEIARRSRGTPRIANRLLRRVRDFAEVRADGVITRDVAKAALAVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEATTVEEVCEPFLVRAGMVARTPRGRVATAQAWTYLCMTPPVGVTGLSQPGLFES
Bibliography
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