Gene ML0484c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD9
Gene length3567 bp
IdentifierML0484c
Location 584382 bp
Protein summary information
Molecular mass130268.0 Da
Isoelectric point5.17
Protein length1189 amino acids
Structural information
PFAMPF00501, PF00550, PF07993
Orthologues
M. tuberculosisRv2590
Cross-references
UniProtQ9CCT4
Gene OntologyAcp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process, Cofactor binding, Metabolic process, L-aminoadipate-semialdehyde dehydrogenase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
CommentsML0484c, len: 1188 aa. Probable fadD9, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to Q50631|Al123456|Rv2590 fadD9, probable fatty-acid-CoA synthetase from M. tuberculosis (1168 aa), fasta scores: E(): 0, (68.0% identity in 1178 aa overlap). Similar to other long chain fatty acid ligases and to domains of polyketide/peptide synthetases e.g. Q10896|Rv0101|MTCY251.20|NRP Probable peptide synthetase from Mycobacterium tuberculosis (2512 aa), FASTA scores: E(): 1.8e-116, (41.313% identity in 1036 aa overlap); Q9RLP6|AJ238027 mps, peptide synthetase from Mycobacterium smegmatis (5990 aa), fasta scores: E(): 4.6e-99, (37.2% identity in 1168 aa overlap). Previously sequenced as O69484|AL023591 (1174 aa), Fasta scores: E(): 0, (100.0% identity in 1174 aa overlap). Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Seems to belong to the ATP-dependent AMP-binding enzyme family, and to the short-chain dehydrogenses/reductases (SDR) family.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS584382587948-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0484c|fadD9
VWRQQSISHRKESVMSTITKQEKQLARRVDDLTANDPQFAAAKPDPAVAAALAQPGLRLPQIIQTALDGYAERPALGQRVAEFTKDPKTGRTSMELLPSFETITYRQLGDRVGALARAWRHDLLHAGYRVCVLGFNSVDYAIIDMALGVIGAVAVPLQTSAAITQLQSIVTETEPSMIATSVNQLPDTVELILSGQAPAKLVVFDYHPEVDEQHDAVATARARLADSSVVVESLTEVLGRGKTLPATPIPVADDSADPLALLIYTSGSTGAPKGAMYLQSNVGKMWRRSDGNWFGPTAASITLNFMPMSHVMGRGILYGTLGNGGTAYFAARSDLSTLLEDLKLVRPTELNFVPRIWETLYDESKRAVDRRLANSGSADRAAIKAEVMDEQRQSLLGGRYIAAMTGSAPTSPELKHGVESLLEMHLLEGYGSTEAGMVLFDGEVQRPPVIDYKLVDVPDLGYFSTDQPYPRGELLLKTQNMFPGYYKRPEVTATVFDSDGYYQTGDIVAEVGPDRLVYVDRRNNVLKLAQGQFVTVAKLEAAFSNSPLVRQIYIYGNSAHPYLLAVVVPTEDALATNDIEVLKPLIIDSLQKVAKEADLQSYEVPRDLIVETTPFSLENGLLTGIRKLAWPKLKQHYGARLEQLYADLVEGQANALHVLKQSVANAPVLQTVSRAVGTILGVATTDLPSNAHFTDLGGDSLSALTFGSLLRELFDIDVPVGVIVSPVNNLVAIADYIERERQGTKRPTFIAIHGRDAGKVHASDLTLDKFIDVSTLTAAPVLAQPGTEVRTVLLTGATGFLGRYLALKWLERMDLVEGKVIALVRAKSNEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGDKGEVDLELDRQTWRRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAELIRIALTSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVISPTRNINNNYANGYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTSYAGQLNVPDMFTRMMLSLAATGIAPGSFYELDAESNRQRAHYDGLPVEFIAEAISTLGDQSLHDRDGFTTYHVMNPHDDGIGMDEFVDWLIDAGCPIQRINDYDEWLRRFEISLRALPERQRHSSLLPLLHNYQKPEKPLHGSLAPTIRFRTAVQNANIGQDKDIPHISPAIIAKYVSDLQLLGLV
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