Gene ML0484c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) |
| Comments | ML0484c, len: 1188 aa. Probable fadD9, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to Q50631|Al123456|Rv2590 fadD9, probable fatty-acid-CoA synthetase from M. tuberculosis (1168 aa), fasta scores: E(): 0, (68.0% identity in 1178 aa overlap). Similar to other long chain fatty acid ligases and to domains of polyketide/peptide synthetases e.g. Q10896|Rv0101|MTCY251.20|NRP Probable peptide synthetase from Mycobacterium tuberculosis (2512 aa), FASTA scores: E(): 1.8e-116, (41.313% identity in 1036 aa overlap); Q9RLP6|AJ238027 mps, peptide synthetase from Mycobacterium smegmatis (5990 aa), fasta scores: E(): 4.6e-99, (37.2% identity in 1168 aa overlap). Previously sequenced as O69484|AL023591 (1174 aa), Fasta scores: E(): 0, (100.0% identity in 1174 aa overlap). Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Seems to belong to the ATP-dependent AMP-binding enzyme family, and to the short-chain dehydrogenses/reductases (SDR) family. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 584382 | 587948 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0484c|fadD9
VWRQQSISHRKESVMSTITKQEKQLARRVDDLTANDPQFAAAKPDPAVAAALAQPGLRLPQIIQTALDGYAERPALGQRVAEFTKDPKTGRTSMELLPSFETITYRQLGDRVGALARAWRHDLLHAGYRVCVLGFNSVDYAIIDMALGVIGAVAVPLQTSAAITQLQSIVTETEPSMIATSVNQLPDTVELILSGQAPAKLVVFDYHPEVDEQHDAVATARARLADSSVVVESLTEVLGRGKTLPATPIPVADDSADPLALLIYTSGSTGAPKGAMYLQSNVGKMWRRSDGNWFGPTAASITLNFMPMSHVMGRGILYGTLGNGGTAYFAARSDLSTLLEDLKLVRPTELNFVPRIWETLYDESKRAVDRRLANSGSADRAAIKAEVMDEQRQSLLGGRYIAAMTGSAPTSPELKHGVESLLEMHLLEGYGSTEAGMVLFDGEVQRPPVIDYKLVDVPDLGYFSTDQPYPRGELLLKTQNMFPGYYKRPEVTATVFDSDGYYQTGDIVAEVGPDRLVYVDRRNNVLKLAQGQFVTVAKLEAAFSNSPLVRQIYIYGNSAHPYLLAVVVPTEDALATNDIEVLKPLIIDSLQKVAKEADLQSYEVPRDLIVETTPFSLENGLLTGIRKLAWPKLKQHYGARLEQLYADLVEGQANALHVLKQSVANAPVLQTVSRAVGTILGVATTDLPSNAHFTDLGGDSLSALTFGSLLRELFDIDVPVGVIVSPVNNLVAIADYIERERQGTKRPTFIAIHGRDAGKVHASDLTLDKFIDVSTLTAAPVLAQPGTEVRTVLLTGATGFLGRYLALKWLERMDLVEGKVIALVRAKSNEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGDKGEVDLELDRQTWRRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAELIRIALTSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVISPTRNINNNYANGYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTSYAGQLNVPDMFTRMMLSLAATGIAPGSFYELDAESNRQRAHYDGLPVEFIAEAISTLGDQSLHDRDGFTTYHVMNPHDDGIGMDEFVDWLIDAGCPIQRINDYDEWLRRFEISLRALPERQRHSSLLPLLHNYQKPEKPLHGSLAPTIRFRTAVQNANIGQDKDIPHISPAIIAKYVSDLQLLGLV
Bibliography
No article yet recorded
