Gene ML0485c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegabT
Gene length1341 bp
IdentifierML0485c
Location 588044 bp
Protein summary information
Molecular mass47182.9 Da
Isoelectric point4.89
Protein length447 amino acids
Structural information
PFAMPF00202
Orthologues
M. tuberculosisRv2589
Cross-references
UniProtP40829
Gene Ontology4-aminobutyrate transaminase activity, Gamma-aminobutyric acid metabolic process, Pyridoxal phosphate binding, (s)-3-amino-2-methylpropionate transaminase activity
Enzyme Classification 2.6.1.22, 2.6.1.19
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEMIALDEHYDE TRANSAMINASE) (GABA AMINOTRANSFERASE) (GABA-AT)
CommentsML0485c, len: 446 aa. Probable gabT, 4-aminobutyrate aminotransferase (EC 2.6.1.9), highly similar to GABT_MYCTU|Q50632|Rv2589 gabT, 4-aminobutyrate aminotransferase from M. tuberculosis (449 aa), Fasta scores: E(): 9.5e-157, (83.7% identity in 449 aa overlap); and CAD94805 4-aminobutyrate aminotransferase from M. bovis (449 aa), fasta scores: E(): 9.5e-157, (83.742% identity in 449 aa overlap). Similar to many e.g. O86823|GABT from Streptomyces coelicolor (444 aa), FASTA scores: E(): 8.9e-111, (61.765% identity in 442 aa overlap); GABT_ECOLI|P22256 gabT, 4-aminobutyrate aminotransferase from Escherichia coli (426 aa), Fasta scores: E(): 0, (43.1% identity in 422 aa overlap). Also similar to ML1216, ML1409 and ML2414. Previously sequenced as GABT_MYCLE|P40829 (446 aa), Fasta scores: E(): 0, (99.8% identity in 446 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS588044589384-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0485c|gabT
VTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVPAEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGTFGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATAAHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF
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