Gene ML0485c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEMIALDEHYDE TRANSAMINASE) (GABA AMINOTRANSFERASE) (GABA-AT) |
| Comments | ML0485c, len: 446 aa. Probable gabT, 4-aminobutyrate aminotransferase (EC 2.6.1.9), highly similar to GABT_MYCTU|Q50632|Rv2589 gabT, 4-aminobutyrate aminotransferase from M. tuberculosis (449 aa), Fasta scores: E(): 9.5e-157, (83.7% identity in 449 aa overlap); and CAD94805 4-aminobutyrate aminotransferase from M. bovis (449 aa), fasta scores: E(): 9.5e-157, (83.742% identity in 449 aa overlap). Similar to many e.g. O86823|GABT from Streptomyces coelicolor (444 aa), FASTA scores: E(): 8.9e-111, (61.765% identity in 442 aa overlap); GABT_ECOLI|P22256 gabT, 4-aminobutyrate aminotransferase from Escherichia coli (426 aa), Fasta scores: E(): 0, (43.1% identity in 422 aa overlap). Also similar to ML1216, ML1409 and ML2414. Previously sequenced as GABT_MYCLE|P40829 (446 aa), Fasta scores: E(): 0, (99.8% identity in 446 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 588044 | 589384 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0485c|gabT
VTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVPAEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGTFGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATAAHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF
Bibliography
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