Gene ML0487 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namesecD
Gene length1794 bp
IdentifierML0487
Location 590037 bp
Protein summary information
Molecular mass63541.7 Da
Isoelectric point9.48
Protein length598 amino acids
Structural information
PFAMPF07549
Orthologs
M. tuberculosis H37RvRv2587c
M. lepromatosis Mx1-22AMLPM_0487
Cross-references
UniProtP38387
Gene OntologyP-p-bond-hydrolysis-driven protein transmembrane transporter activity, Integral to membrane, Intracellular protein transmembrane transport, Plasma membrane, Protein secretion by the type ii secretion system, Type ii protein secretion system complex, Gram-negative-bacterium-type cell wall
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable protein-export membrane protein SecD
CommentsML0487, len: 597 aa. Probable secD, protein-export membrane protein (integral membrane protein) (see citation below), highly similar to SECD_MYCTU|Q50634|Rv2587c secD, putative protein-export membrane protein from M. tuberculosis (573 aa), Fasta scores: E(): 3.5e-141, (80.6% identity in 583 aa overlap); and CAD94803|Mb2618c from M. bovis (573 aa). Also similar to others e.g. Q53955|SECD_STRCO from Streptomyces coelicolor (570 aa), FASTA scores: E(): 2.6e-35, (37.655% identity in 563 aa overlap. Previously sequenced as SECD_MYCLE|P38387 (571 aa), Fasta scores: E(): 0, (99.8% identity in 571 aa overlap). Contains hydrophobic, possible membrane-spanning regions. Belongs to the secD/secF family, secD family. Part of the prokaryotic protein translocation apparatus which comprises SecA1|ML0799, SecA2|ML2082c, SecD|ML0487, secG|ML0577,, SecE|ML1907, SecF|ML0488 and SecY|ML1833.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS590037591830+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0487|secD
VSCVKGLVMRHVGSVGKNRFRGDTRNVASSSAPVHFGRYLSMFLVLFIGVYLLAFLTGDKRVVPRLGIDLQGGTRVTLTARTPDGSRPSREALSQAQQIISSRVNGLGVSGSEVVVDGDNLVITVPGNDGNEARNLGQTARLYIRPVLNSLPVQRGQDPKPGSPAGTLPNFAPMPPDHPGAQPRPYLQDPTSSPSSDPMPSPVPTGAALPGEVPSVEQPAPPDPRKDLAERIAEEKKWRQSTKQSIQFLALQFESTHCDKDDILAGNDDPNLPLATCSTDHNMAYLLAPSIISGDQIQNSTSGMNQRGVGYVVDLQFKSAAADVWADFTAAHIGTQTAFTLDSEVVSVPVINEAILGGRTQISGGDPPFTAATARQLANVLKYGSLPLSFEPSEAQTVSATLGLTSLRAGLIAGAIGLSLVLLYSLLYYRVLGLLTAFSLFCSGTIIFAILVLLGRYINYTLDLAGIAGLIIGIGTTADSFVVFFERIKDEIREGRSFRSAVPRGWVRARKTIVSGNAVTFLAAAVLHFLAIGQVKGFAFTLGLTTILDLVVVFLVTWPLVYLASKSPLLARPAYNGLGAVQQVARERRASAKTGRG
Bibliography
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