Gene ML0492c (ppi)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable peptidyl-prolyl cis-trans isomerase B PpiB (Cyclopphilin) (Ppiase) (Rotamase) (Peptidylprolyl isomerase) |
| Comments | ML0492c, len: 295 aa. Probable ppiB, cyclophilin (peptidyl-prolyl cis-trans isomerase) (EC 5.2.1.8), highly similar to CYPB_MYCTU|Q50639|Rv2582 ppiB, probable peptidyl-prolyl cis-trans isomerase from M. tuberculosis (308 aa), Fasta scores: E(): 1.3e-79, (72.5% identity in 295 aa overlap); and CAD94798|Mb2613 from M. bovis (308 aa). Also similar to others e.g. Q9KJG8|PPIB PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces lividans (277 aa), FASTA scores: E(): 4.1e-24, (40.268% identity in 298 aa overlap). Previously sequenced as CYPB_MYCLE|P46697 (295 aa), Fasta scores: E(): 0, (99.7% identity in 295 aa overlap). Contains hydrophobic, possible membrane-spanning region. Alternatively, this may represent an N-terminal signal sequence, given the potential start codon at codon 33. Contains Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase. Belongs to the cyclophilin-type Ppiase family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 598030 | 598917 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0492c|ppiB
VPTNEQRRATAKRKLKRQLERRAKQARWRRVLLISGGVVVAVAVIITVVATVVISKLGHKHDTASSTASNSLTATKTPAVTPSVLPLPSFQPSTNLGVNCQYPPSADKAAKPVKPPRAGKVPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLTGQGFFNNTKCHRLTTSLMLGVLQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPRGTLAMANSGPNTNGSQFFLVYHDSQLPPEYTVFGTIQADGLATLDKIAKGGIASGGDDGPPATEVTIESLRLD
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