Gene ML0512 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namealaS
Gene length2727 bp
IdentifierML0512
Location 622160 bp
Protein summary information
Molecular mass97773.1 Da
Isoelectric point5.01
Protein length909 amino acids
Structural information
PFAMPF01411, PF02272, PF07973
Orthologs
M. tuberculosis H37RvRv2555c
M. lepromatosis Mx1-22AMLPM_0512
Cross-references
UniProtQ9CCT0
Gene OntologyAlanine-trna ligase activity, Alanyl-trna aminoacylation, Cytoplasm, Nucleic acid binding, Atp binding
Enzyme Classification6.1.1.7
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable alanyl-tRNA synthetase AlaS (Alanine--tRNA ligase) (Alanine translase) AlaRS)
CommentsML0512, len: 908 aa. Probable alaS, alanyl-tRNA synthetase (EC 6.1.1.7), highly similar to SYA_MYCTU|O07438|Rv2555c alaS, alanyl-tRNA synthetase from M. tuberculosis (904 aa), Fasta scores: E(): 0, (84.7% identity in 907 aa overlap); and CAD94770|Mb2585c from M. bovis (904 aa). Similar to many e.g. Q9KXP9|SYA_STRCO from Streptomyces coelicolor (890 aa), FASTA scores: E(): 1.5e-117, (52.150% identity in 907 aa overlap). Contains Pfam match to entry PF01411 tRNA-synt_2c, tRNA synthetases class II (A). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Belongs to the class-II aminoacyl-tRNA synthetase family.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS622160624886+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0512|alaS
VQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFVPFFLGQCTPPYATATSIQKCIRTPDIDDVGITTRHNTFFQMAGNFSFGDYFKRGAIELAWALLTNSFADGGYGLDPERLWATVYLDDDEAAGLWQEIAGLPPERIQRRGMADNYWSMGIPGPCGPSSEIYYDRGPEFGPEGGPIVNEDRYLEVWNLVFMQNERGEGTTKEDYEIRGPLPRKNIDTGMGVERIALVLQGVHNVYEIDLLRPVIDLVATRAPRPYDPENEDTNHADNVRYRIIADHSRTAAILIGDGVSPVNDGRGYVLRRLLRRIIRSAKLLGIDSPIVGDLMATVCNAMGRAYPGLVTDFDRINRIAVAEETAFNRTLTSGSKLFDDVVGATVASGSTVVAGLDAFTLHDTYGFPIELTLEMAAEAGLTVDEKGFHELMLQQRQRAKVDAAARKQAHVDLTAYRELVDAGPTEFTGFDELTTEARILGIFVEGKRVPVVAHAVRGQAGITNRVELVLDRTPLYAESGGQIADAGTISGIGAGASSRAAVTDVQKIAKTLHVHRVNLESGEFVEGDTVVAVVDPGWRRGAAQGHSGTHIVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGSLTGEQRTQIEEVTNEAVQADFEVHTFTEKLDTAKAMGAIALFGEAYPDEVRVVEMGGPFSLELCGGTHVHNTAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLQVPSEEVHARVATLVERLKAAEKELERARQANVQAAATKAAAGAEWIGNVRVVVQRMSGPIAPDDLRFLVGDIRGKLGSDPAVVALIAVTSDGPTATVPYAVAANPAAQDLGIRANDLVEQLAMVVDGRGGGKADLAQGSGKDPTGIDAALDTVRAQIAQVG
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