Gene ML0516 (aroC) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namearoF
Gene length1224 bp
IdentifierML0516
Location 627742 bp
Protein summary information
Molecular mass42441.0 Da
Isoelectric point5.52
Protein length408 amino acids
Structural information
PFAMPF01264
Orthologs
M. tuberculosis H37RvRv2540c
M. lepromatosis Mx1-22AMLPM_0516
Cross-references
UniProtQ9CCS6
Gene OntologyChorismate synthase activity, Aromatic amino acid family biosynthetic process
Enzyme Classification4.2.3.5
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductChorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase).
CommentsML0516, len: 407 aa. aroF, chorismate synthase (EC 4.6.1.4), highly similar to AROC_MYCTU|P95013|Rv2540c aroF, chorismate synthase from M. tuberculosis (401 aa), Fasta scores: E(): 0, (88.0% identity in 401 aa overlap); and CAD94754|Mb2569c from M. bovis (401 aa). Similar to many e.g. Q9KXQ4|AROC_STRCO|SC9C5.20c from Streptomyces coelicolor (394 aa), E(): 6.3e-98, (65.365% identity in 384 aa overlap). Contains Pfam match to entry PF01264 Chorismate_synt, Chorismate synthase. Contains PS00788 Chorismate synthase signature 2. Contains PS00789 Chorismate synthase signature 3. Contains PS00787 Chorismate synthase signature 1. Belongs to the Chorismate synthase family. Cofactor: Reduced flavin.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS627742628965+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0516|aroF
VLRWITAGESHGRALVAVVEGMVAGVEVTSTAIADQLARRRLGYGRGARMAFERDGVTVLSGVRHGVTLGGPIAIEIDNTEWPKWESVMAADPVDAAELEDSARNAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTIARQFLRQALGVEVLSHVISIGASARYDGPPPGSEDLTVIDASLVRAFDEQVEKSMIAEIEAAKKDGDTLGGVVEAVVLGLPVGLGSFTSGDDRLDSQLAAAVMGIQAIKGVEIGDGFATARRRGSCAHDEMYSGPGGVVRLTNRSGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDLATGEEAIAIHQRSDVCAVPAAGVVVETMVALVLARAALRKFGGDSLGETRRNLAAYQRAVADREAPVAQYCGESGIGG
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