Gene ML0517 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namearoK
Gene length600 bp
IdentifierML0517
Location 628973 bp
Protein summary information
Molecular mass21084.2 Da
Isoelectric point9.63
Protein length200 amino acids
Structural information
PFAMPF01202
Orthologs
M. tuberculosis H37RvRv2539c
M. lepromatosis Mx1-22AMLPM_0517
Cross-references
UniProtQ9CCS5
Gene OntologyAromatic amino acid family biosynthetic process, Cytoplasm, Magnesium ion binding, Shikimate kinase activity, Atp binding
Enzyme Classification2.7.1.71
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductShikimate kinase AroK (SK)
CommentsML0517, len: 199 aa. aroK, shikimate kinase (EC 2.7.1.71), highly similar to AROK_MYCTU|P95014|Rv2539c aroK, shikimate kinase from M. tuberculosis (176 aa), Fasta scores: E(): 0, (79.6% identity in 167 aa overlap); and CAD94753|Mb2568c from M. bovis (176 aa). Similar to many e.g. AROK_ECOLI|P24167 aroK, shikimate kinase I from Escherichia coli (172 aa), Fasta scores: E(): 3.5e-13, (38.0% identity in 166 aa overlap). Contains Pfam match to entry PF01202 SKI, Shikimate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS01128 Shikimate kinase signature. Belongs to the Shikimate kinase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS628973629572+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0517|aroK
MAPKAVLVGLPGAGKSTIGRRLSKALGVSLLDTDAAIEKQTGRSIADIFAIDGEEEFRRIEEGVVRAALVEHDGVVSLGGGAVTSPGVCAALAGHIVIYLEINAEEAMRRACGSTVRPLLAGPDRAEKFQDLMARRVPLYRRVATIRVDTNCHNLGAVVRYIMARLQAQLATPVSGGDRKSSEAERSGAPLRKSSEVVK
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