Gene ML0518 in Mycobacterium leprae TN
Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namearoB
Gene length1086 bp
IdentifierML0518
Location 629569 bp
Protein summary information
Molecular mass38031.6 Da
Isoelectric point5.57
Protein length362 amino acids
Structural information
PFAMPF01761
Orthologs
M. tuberculosis H37RvRv2538c
M. lepromatosis Mx1-22AMLPM_0518
Cross-references
UniProtQ9CCS4
Gene OntologyAromatic amino acid family biosynthetic process, Cytoplasm, 3-dehydroquinate synthase activity
Enzyme Classification4.2.3.4
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Product3-dehydroquinate synthase AroB
CommentsML0518, len: 361 aa. aroB, 3-dehydroquinate synthase (EC 4.6.1.3), highly similar to AROB_MYCTU|P36919|Rv2538c aroB, 3-dehydroquinate synthase from M. tuberculosis (362 aa), Fasta scores: E(): 0, (87.3% identity in 361 aa overlap); and CAD94752|Mb2567c from M. bovis (362 aa). Also highly similar to many e.g. Q9KXQ6|AROB_STRCO from Streptomyces coelicolor (363 aa), FASTA scores: E(): 2.1e-77, (58.146% identity in 356 aa overlap). Contains Pfam match to entry PF01761 DHQ_synthase, 3-dehydroquinate synthase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS629569630654+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0518|aroB
MTNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRHRVAILHQPVLTQTAEAIRSHLAGKGVDAHRIEIPDAEAGKDLSVMDFIWEVLGRIGIGRKDALVSFGGGAATDVAGFAAATWLRGVSIVHVPTTLLGMVDAAVGGKTGINTEAGKNLVGAFHQPLAVLADLATLETLPRKEIASGMAEVVKAGFIADPIILDLIEADPQASLDPMGGVLPELIRRAVTVKAGVVSADEKESELREILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAELARVAGRLDDATAQRHHTILTSLGLPVSYDADALPQLLEYMAGDKKTRAGVLRFVILDGLAKPGRLVGPDPGLLVTAYAGLSA
Bibliography
No article yet recorded