Gene ML0522
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PEPTIDE BOND SYNTHESIS. STIMULATE EFFICIENT TRANSLATION AND PEPTIDE-BOND SYNTHESIS ON NATIVE OR RECONSTITUTED 70S RIBOSOMES IN VITRO. PROBABLY FUNCTIONS INDIRECTLY BY ALTERING THE AFFINITY OF THE RIBOSOME FOR AMINOACYL-TRNA, THUS INCREASING THEIR REACTIVITY AS ACCEPTORS FOR PEPTIDYL TRANSFERASE. |
| Product | Probable elongation factor P Efp |
| Comments | ML0522, len: 187 aa. Probable efp, elongation factor P, highly similar to EFP_MYCTU|P95019|Rv2534c efp, elongation factor P from M. tuberculosis (187 aa), Fasta scores: E(): 2.8e-76, (94.1% identity in 186 aa overlap); and CAD94748|Mb2563c from M. bovis (187 aa). Similar to many e.g. Q45288|EFP_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (187 aa), FASTA scores: E(): 6.3e-55, (69.892% identity in 186 aa overlap). Contains Pfam match to entry PF01132 EFP, Elongation factor P (EF-P). Contains PS01275 Elongation factor P signature. Belongs to the elongation factor P family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 632968 | 633531 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0522|efp
VATTADFKNGLVLVIDGQLWTIIGFQHVKPGKGPAFVRTKLKNVLSGKVVDKTYNAGVKVDTATVDRRDTTYLYRDGANFVFMDSQDYEQHPLPESLVGDTARFLLEGMSVQVAFHNGVPLYVELPVTVELEVTHTEPGLQGDRSSAGTKPATLETGAQINVPLFINTGDKLKVDSRDGSYLGRVNV
Bibliography
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