Gene ML0524 (adi) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML0524
Gene length2853 bp
IdentifierML0524
Location 634644 bp
Protein summary information
Molecular mass106502.0 Da
Isoelectric point5.55
Protein length951 amino acids
Structural information
PFAMPF01276, PF03711
Orthologs
M. tuberculosis H37RvRv2531c
M. lepromatosis Mx1-22AMLPM_0524
Cross-references
UniProtQ9CCR8
Gene OntologyPyridoxal phosphate binding, Catalytic activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable amino acid decarboxylase
CommentsML0524, len: 950 aa. Probable amino acid decarboxylase (EC 4.1.1.-), highly similar to P95022|AL123456|Rv2531c Probable amino acid decarboxylase from M. tuberculosis (947 aa), Fasta scores: E(): 0, (86.4% identity in 951 aa overlap); and CAD94745|Mb2560c from M. bovis (947 aa). Similar to decarboxylases of ornithine/arginine/lysine e.g. Q9I2S7|PA1818 Probable Orn/Arg/Lys decarboxylase from Pseudomonas aeruginosa (751 aa), FASTA scores: E(): 4.9e-20, (28.807% identity in 729 aa overlap); and DCOR_ECOLI|P21169 speC, ornithine decarboxylase (constitutive) from Escherichia coli (731 aa), Fasta scores: E(): 3e-16, (26.8% identity in 650 aa overlap). Contains Pfam match to entry PF01276 OKR_DC_1, Orn/Lys/Arg decarboxylase. Seems to belong to the family of ornithine, lysine and arginine decarboxylases. Note that previously known as adi.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS634644637496+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0524|ML0524
MNRDSGHPRRLRVSALAAVANPSYTRIDTWNVLDDACRHLAEVDRAGLDTAHDVARVKRLLDRIGAYERYWLYPGAANLAAFRGYLATMATVQLTEEVSLAVRLLSEYGDRTALFDTSAPLADQELVAQAKQQQFYTVLLADDAPSTAPDCLAESLRELRNPSDDVQFELLVVSSVEDAITAVALNGEIQAAIIRHDLPLRSRDRVPLMNTLLGANDSEGALVTIDRPHDWVECGEWIRELRPHIDLYLLTDESIAAGNDDEPDVYDRTFYRLNDVTDLNSTVLAGLRNRFATPFFDALRAYAAAPVGQFHALPVARGASIFNSRSLQDMGEFYGRNIFMAETSTTSGGLDSLLDPHGNIKKAMDKAAVTWRANHTYFVTNGTSTANKIVVQSLTRPGDIVLIDRNCHKSHHYGLVLAGAYPMYLDAYPLPQFAIYGAVSLRTIKKALLDLEAVRQLDRVRMLLLTNCTFDGVVCNPQRVMEEVLAIKPDICFLWDEAWYAFATAVPWARQRTAMVSAEQLEQKLWSVEYAEEYRNWCASMAEIPRSQWVDQRLLPDPNRARIRVYATHSTHKSLSALRQASMIHVRDQDFNALARDAFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFQLVRLVYDMALVFRHRVRKDRLISKWFRILDESDLVPDEYRASAVSSYRQVRQGALAEWNEAWRSDQFVLDPTRVTLFVGKTGMNGYDFREKILMERFGIQINKTSINSVLLIFTIGVTWSSVHYLLDVLRRVASDFDRIQKVASGADLALHQRHVEEITQDLPHLPDFSEFDVAFRPENASSFGDMRSAFYAGYEESDREYVHIGTAGRQLAEGRTLVSTTFVVPYPPGFPVLVPGQVVSKEIIYFLAQLDVKEIHGYNHELGLSVFTEKALARMIARRNAASAAVGSAFAAFEIPSDSAAMGGDVNGDRVEAVAEDA
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