Gene ML0532
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable aspartate carbamoyltransferase PyrB (Aspartate transcarbamylase) (ATCase) |
| Comments | ML0532, len: 321 aa. Probable pyrB, aspartate carbamoyltransferase (EC 2.1.3.2), highly similar to PYRB_MYCTU|P71808|Rv1380 pyrB, aspartate carbamoyltransferase from M. tuberculosis (319 aa), Fasta scores: E(): 0, (89.9% identity in 318 aa overlap); and CAD94276|Mb1415 from M. bovis (319 aa). Similar to many e.g. PYRB_STRCO|Q9KXR2 Aspartate carbamoyltransferase from Streptomyces coelicolor (326 aa), fasta scores: E(): 3.8e-74, (60.559% identity in 322 aa overlap); and PYRB_PSEPU|Q59711 aspartate carbamoyltransferase from Pseudomonas putida (334 aa), Fasta scores: (47.3% identity in 317 aa overlap). And weakly similarity to ML1410. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature. Belongs to the ATCases/OCTases family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 645582 | 646547 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0532|pyrB
VMRRHLLNAGDLSRDDAIAIFDDADRFAHALVGREIKKLPTLRGRTVITMFYENSTRTRVSFEVAGKWMSANVINVSPAGSSVGKGESLRDTALTLRAAGADALIIRHPASGAAHLLADWTAAETGEDGPAVINAGDGTHEHPTQALLDALTIRQRLGSIEGRRILIVGDILHSRVARSNVVLLDTLGAEVVLVAPRTLLPIGVDGWPATVSCDFDAELPAADAVLMLRVQAERMNGGFFPSVREYSCLYGLTERRQALLPGHAVVLHPGPMLRGMEIASSVADSSQSAVLQQVSNGVHVRMAVLFHVLVGTQSAEEEGAA
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