Gene ML0533
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable dihydroorotase PyrC (DHOase) |
| Comments | ML0533, len: 430 aa. Probable pyrC, dihydroorotase (EC 3.5.2.3), highly similar to P71809|AL123456|Rv1381 probable pyrC, dihydroorotase from M. tuberculosis (430 aa), Fasta scores: E(): 0, (88.8% identity in 427 aa overlap); and CAD94277|Mb1416 from M. bovis (430 aa). Similar to many e.g. PYRC_BACCL|P46538 pyrC, dihydroorotase from Bacillus caldolyticus (427 aa), Fasta scores: E(): 4.1e-52, (40.0% identity in 407 aa overlap). Contains Pfam match to entry PF00744 Dihydrooratase, Dihydroorotase-like. Belongs to the DHOase family. Subfamily 2. Cofactor: Binds 2 zinc ion per subunit. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 646544 | 647836 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0533|pyrC
MSVLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDIPDTADVIDAIDQVLLPGLVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMAAGAAQVRIFSDDGNCVHNPLVMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEILKWAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLRETADAVALRQALADGIIDCVTTDHAPHADHEKCVEFSAARPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARIAGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDGLASRSANTPYEAMTLPATVTATLLRGKVTARGQKSPV
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