Gene ML0536
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable carbamoyl-phosphate synthase large subunit CarB (Carbamoyl-phosphate synthetase ammonia chain) |
| Comments | ML0536, len: 1129 aa. Probable carB, Carbamoyl-phosphate synthase large chain (EC 6.3.5.5), highly similar to P57689|CARB_MYCTU|Rv1384 carB, carbamoyl-phosphate synthase subunit from M. tuberculosis (1115 aa), fasta scores: E(): 0, (88.839% identity in 1111 aa overlap) ; and CAD94280|Mb1419 from M. bovis (1115 aa). Highly similar to many e.g. CARB_ECOLI|P00968 carB, carbamoyl-phosphate synthase subunit from Escherichia coli (1072 aa), Fasta scores: (51.4% identity in 1116 aa overlap). Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. SUBUNIT: COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE. Belongs to the CarB family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 649609 | 652998 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0536|carB
LRPERGTLVPRRTDLNHVLVIGSGPIVIGQACEFDYAGTQACRVLRAEGLQVSLVNSNPATIMTDPEFADHTYVEPITPAFVERVIVQQAERGNRIDALLATLGGQTALNTAVALYENGVLERYGVELIGADFEAIQRGEDRQRFKDLVAKVGGESARSKVCFTMDEVRETVEDLGLPVVVRPSFTMGGLGSGMAHSDEEVGRMAGAGLVASPSANVLIEESVYGWKEFELELMRDGHDSVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDWEYQRMRDLGIAILREVGVDTGGCNIQFAINPHDGRLIVIEMNPRVSRSSALASKATGFPIAKIAVKLAVGYTLDEILNDITKETPACFEPALDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEALGKVMRSLETGRFGFWTAPDPQGDVDQVLLRLKTPTEGRLYDVELALRLGASTEKVAQVSGIDPWFVAQIGELVKLRDELVAAPVLDAELLRRAKHNGLSDRQITALRPELLGEDGVRSLRKRLGIHPVYKTVDTCAAEFEAKTPYHYSSYELDPAAETEVVPQTEKPKVLILGSGPNRIGQGIEFDYSCVHAAITLSHNGFETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEVFYAEEQSAAGGAGVAGVIVQLGGQTPLGLAQRLADAGVPIVGTSPEAIDLAEDRGAFGDVLTAAGLPAPKYGTATTFAQARRIAAEIGYPVLVRPSYVLGGRGMEIVYDEETLKDYITRATALSHEHPVLVDRFLEDAVEIDVDALCDGTEVYIGGVMEHIEEAGIHSGDSACALPPVTLGRSDLEKVRQATEAIARGIGVVGLLNVQYALKEDVLYVLEANPRASRTVPFVSKATAIPLAKACARIMLGSSISQLRFEGMLAASGDGGNVASHAPIAVKEAVLPFNRLRRADGAAIDSLLGPEMKSTGEVMGIDHDFGRAFAKSQTAAYGSLPTQGTVFVSVANRDKRLLVFPVKRLADLGFHVIATEGTAEMLRRKGIPCDEVRKHFEPPKAGRPALSAVDAIRAGDVDMVINTPYGNSGPRIDGYEIRSAAVSVNIPCVTTVQGASAAVQGIEAGIRGDIGVRSLQELHSAIGAGIAADNEVQ
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