Gene ML0541 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegmk
Gene length633 bp
IdentifierML0541
Location 657267 bp
Protein summary information
Molecular mass22625.6 Da
Isoelectric point5.14
Protein length211 amino acids
Structural information
PFAMPF00625
Orthologues
M. tuberculosisRv1389
Cross-references
UniProtQ9CCQ7
Gene OntologyCytoplasm, Guanylate kinase activity, Purine nucleotide metabolic process, Atp binding
Enzyme Classification2.7.4.8
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable guanylate kinase Gmk (GMP kinase).
CommentsML0541, len: 210 aa. Probable gmk, guanylate kinase (EC 2.7.4.8), highly similar to KGUA_MYCTU|P71659|Rv1389 gmk, putative guanylate kinase from M. tuberculosis (208 aa), Fasta scores: E(): 1.8e-62, (79.1% identity in 201 aa overlap). Similar to many e.g. Q9KXS0|KGUA_STRCO Guanylate kinase from Streptomyces coelicolor (197 aa), fasta scores: E(): 3e-31, (53.889% identity in 180 aa overlap). Contains Pfam match to entry PF00625 Guanylate_kin, Guanylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00856 Guanylate kinase signature. Belongs to the Guanylate kinase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS657267657899+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0541|gmk
VPVSARGAPDAEHWAWSEQTDKGRVVVLSGPSAVGKSTVVRCLRERVSNLHFSVSATTREPRPDEMDGVDYHFVSPARFQQLIDQGALLEWAEIHGGMHRSGTLAEPVRVAAAAGFPVLIEVDLAGARAVKKAMPEAIAVFLAPPSWEDLEARLVGRGTETPEAIRRRLETARIELAAQDDFDEVVVNRRLESACAELVSLLVGAVSGSA
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