Gene ML0544
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in the activated Methyl cycle. Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. [CATALYTIC ACTIVITY : ATP + L-METHIONINE + H(2)O = PHOSPHATE + DIPHOSPHATE + S-ADENOSYL-L-METHIONINE] |
| Product | Probable S-adenosylmethionine synthase MetK (MAT) (AdoMet synthetase) (Methionine adenosyltransferase) |
| Comments | ML0544, len: 403 aa. Probable metK, S-adenosylmethionine synthetase (EC 2.5.1.6), highly similar to METK_MYCTU|P77899|Rv1392 metK, putative S-adenosylmethionine synthase from M. tuberculosis (403 aa), Fasta scores: E(): 9.7e-149, (91.3% identity in 403 aa overlap); and CAD94288|Mb1427 from M. bovis (403 aa). Similar to others e.g. METK_STRST|Q9X4Q2 metK, S-adenosylmethionine synthase from Streptomyces spectabilis (411 aa), Fasta scores: E(): 2.3e-115, (73.6% identity in 398 aa overlap). Contains Pfam match to entry PF00438 S-AdoMet_synt, S-adenosylmethionine synthetase. Contains PS00377 S-adenosylmethionine synthetase signature 2. Contains PS00376 S-adenosylmethionine synthetase signature 1. Belongs to the AdoMet synthetase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 659722 | 660933 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0544|metK
VSEKGRLFTSESVTEGHPDKICDAISDSILDALLAEDPCSRVAVETLVTTGQVHVVGEVTTLAKTAFADISNTVRERILDIGYDSSDKGFDGASCGVNIGIGAQSSDIAQGVNTAHEVRVEGAADPLDAQGAGDQGLMFGYAINDTPELMPLPIALAHRLARRLTEVRKNGVLPYLRSDGKTQVTIAYEDNVPVRLDTVVISTQHAAGVDLDATLAPDIREKVLNTVIDDLSHDTLDVSSVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNIVAAGLAERIEVQVAYAIGKAAPVGLFVETFGTEAVDPAKIEKAIGEVFDLRPGAIIRDLHLLRPIYAQTAAYGHFGRTDVELPWEQLNKVDDLKRAI
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